WorldWideScience

Sample records for action review draft

  1. A national program for energy-efficient mortgages and home energy rating systems: A blueprint for action. Review draft

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    This Review Draft reports findings and recommendations of the National Collaborative on Home Energy Rating Systems and Mortgage Incentives for Energy Efficiency. The US Department of Energy, in cooperation with the US Department of Housing and Urban Development, formed this National Collaborative as a National Energy Strategy initiative. Participating in the Collaborative were representatives of the primary and secondary mortgage markets, builder and remodeler organizations, real estate and appraiser associations, the home energy rating system industry, utility associations, consumer and public interest groups, state and local government interest groups, and environmental organizations. The Collaborative`s purpose was to develop a voluntary national program encouraging energy efficiency in homes through mortgage incentives linked to home energy ratings.

  2. Draft Guidance for Protective Action Strategies Development

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Hyun; Jeong, Seung Young; Kim, Wanjoo [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2016-10-15

    National nuclear emergency preparedness and response (EPR) framework has been improved since the Fukushima accident in 2011. There are still many needs to be amended and improved in regulatory requirements and technical criteria to warrant efficacy of the EPR framework. As an important part of the framework, protective actions have to be implemented with optimized and justified manner during whole emergency phases. In this study, to enhance protective action strategies in response to severe accident or general emergency, existing procedures were reviewed. And generic guidance to develop protective action recommendations (PARs) was proposed considering revised EPZ and recent technical information on protective action strategies. The generic guidance for PARs based on facility status was introduced. Revision of EPZ and some recent information on protective action strategies, such as staged evacuation, specific approach for rapidly progressing accident were considered. It would be employed as a basis to develop site-specific strategies of PARs and regulatory guidance for emergency plan by nuclear licensee. It was focused on an early phase of nuclear emergency. Further efforts to develop site specific strategies of PARs and strategies which cover full range of nuclear emergency would be followed by several stake holders.

  3. IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)

    Science.gov (United States)

    On May 3, 2013, the Toxicological Review of Methanol (noncancer) (Revised External Review Draft) was posted for public review and comment. Subsequently, the draft Toxicological Review, Appendices, and draft IRIS Summary were reviewed internally by EPA and by other federal agenci...

  4. 77 FR 38296 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    Science.gov (United States)

    2012-06-27

    ... HUMAN SERVICES Centers for Disease Control and Prevention Draft Public Health Action Plan--A National Public Health Action Plan for the Detection, Prevention, and Management of Infertility AGENCY: Centers... Federal Register requesting public comment on the draft National Public Health Action Plan for the...

  5. 77 FR 28883 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    Science.gov (United States)

    2012-05-16

    ... HUMAN SERVICES Centers for Disease Control and Prevention Draft Public Health Action Plan--A National Public Health Action Plan for the Detection, Prevention, and Management of Infertility AGENCY: Centers... requesting public comment on the draft National Public Health Action Plan for the Detection, Prevention, and...

  6. IRIS Toxicological Review of Acrylonitrile (Interagency Science Consultation Draft)

    Science.gov (United States)

    On June 30, 2011, the draft Toxicological Review of Acrylonitrile and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House...

  7. IRIS Toxicological Review for Acrylamide (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review for Acrylamide, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process<...

  8. Integrated Science Assessment (ISA) of Ozone and Related Photochemical Oxidants (Second External Review Draft, Sep 2011)

    Science.gov (United States)

    EPA has released the Integrated Science Assessment of Ozone and Related Photochemical Oxidants (Second External Review Draft) for independent peer review and public review. This draft document represents a concise synthesis and evaluation of the most policy-relevant scienc...

  9. IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Consultation Draft)

    Science.gov (United States)

    On March 31, 2010, the draft IRIS Toxicological Review of Dichloromethane (Methylene Chloride) external review draft document and the charge to external peer reviewers were released for public review and comment. The draft document and the charge to external peer reviewers were r...

  10. 75 FR 69078 - Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA)

    Science.gov (United States)

    2010-11-10

    ... AGENCY Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA) AGENCY... a workshop to evaluate initial draft materials for the Pb Integrated Science Assessment (ISA) is... the scientific content of initial draft materials or sections for the draft ISA. Workshop sessions...

  11. Review of Final Draft Core Standards

    Directory of Open Access Journals (Sweden)

    R. James Milgram

    2013-04-01

    Full Text Available What follows are my comments on the nal draft of the CCSSI Core Mathematics Standards. There are a number of standards including, but not limited to 1-OA(6, 2-OA(2, 2-NBT(5, 3-OA(7, 3-NBT(2, 4-OA(4, 4-OA(6, 4-NF(1, 4-NF(2, 5-OA(3, 8-G(2, 8-G(4, F-LQE(5, G-SRT(4 that are completely unique to this document, andmost of them seem problematic to me. I have repeatedly asked for references justifying the insertions of these or similar standards in previous drafts, but references have not been provided. Consequently, to my knowledge, there is no real research base for including any of these standards in the document.

  12. 75 FR 50761 - Draft Toxicological Review of Dichloromethane: In Support of Summary Information on the...

    Science.gov (United States)

    2010-08-17

    ... AGENCY Draft Toxicological Review of Dichloromethane: In Support of Summary Information on the Integrated... workshop to review the draft human health assessment titled, ``Toxicological Review of Dichloromethane: In... draft assessment for Dichloromethane will be held on September 23, beginning at 8:30 a.m. and ending at...

  13. 77 FR 5797 - Draft Toxicological Review of Vanadium Pentoxide: In Support of Summary Information on the...

    Science.gov (United States)

    2012-02-06

    ... the meeting regarding the draft assessment under review. Space is limited, and reservations will be..., or logistics for the external peer review meeting, please contact Versar by calling (703) 750-3000... AGENCY Draft Toxicological Review of Vanadium Pentoxide: In Support of Summary Information on the...

  14. 75 FR 45112 - Draft Toxicological Review of Hexachloroethane: In Support of Summary Information on the...

    Science.gov (United States)

    2010-08-02

    ... provide written comments at the workshop regarding the draft assessment under review. Space is limited... for individuals with disabilities, or logistics for the external peer review workshop, please contact... AGENCY Draft Toxicological Review of Hexachloroethane: In Support of Summary Information on the...

  15. 75 FR 30825 - Draft Toxicological Review of Formaldehyde in Support of Summary Information on the Integrated...

    Science.gov (United States)

    2010-06-02

    ... public listening session for the external review draft human health assessment titled, ``Toxicological... National Research Council, acting under the auspices of National Academy of Sciences (NAS), will conduct an independent scientific peer review of the EPA draft human health assessment of formaldehyde. The peer review...

  16. Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria (First External Review Draft, Sep 2007)

    Science.gov (United States)

    EPA has announced that the First External Review Draft of the Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise synthesis and evaluatio...

  17. Integrated Science Assessment (ISA) for Carbon Monoxide (Second External Review Draft, Sep 2009)

    Science.gov (United States)

    EPA announced that the Second External Review Draft of the Integrated Science Assessment (ISA) for Carbon Monoxide (CO) and related Annexes was made available for independent peer review and public review. This draft ISA document represents a concise synthesis and evaluation of t...

  18. Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria (Second External Review Draft, 2008)

    Science.gov (United States)

    EPA has announced that the Second External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise synthesis and evaluation...

  19. Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria (First External Review Draft, 2007)

    Science.gov (United States)

    EPA has announced that the First External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise synthesis and eva...

  20. An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios (External Review Draft)

    Science.gov (United States)

    EPA has released an external review draft entitled, An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios(External Review Draft). The public comment period and the external peer-review workshop are separate processes that provide opportunities ...

  1. 78 FR 12764 - Draft Office of Health Assessment and Translation Approach for Systematic Review and Evidence...

    Science.gov (United States)

    2013-02-25

    ... HUMAN SERVICES National Institutes of Health Draft Office of Health Assessment and Translation Approach for Systematic Review and Evidence Integration for Literature-Based Health Assessments--February 2013... comments on the Draft Office of Health Assessment and Translation (OHAT) Approach for Systematic Review and...

  2. 76 FR 38387 - Draft Toxicological Review of Acrylonitrile: In Support of Summary Information on the Integrated...

    Science.gov (United States)

    2011-06-30

    ... AGENCY Draft Toxicological Review of Acrylonitrile: In Support of Summary Information on the Integrated... Review of Acrylonitrile: In Support of Summary Information on the Integrated Risk Information System... draft assessment for acrylonitrile will be held on August 10, 2011, beginning at 9 a.m. and ending at 4...

  3. Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria (First External Review Draft, 2013)

    Science.gov (United States)

    EPA is announcing the availability of the First External Review Draft of the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria for public comment and independent peer review. This draft document provides EPA’s evaluation and synthesis of the most polic...

  4. 75 FR 1617 - Draft Toxicological Review of Methanol: In Support of the Summary Information in the Integrated...

    Science.gov (United States)

    2010-01-12

    ... AGENCY Draft Toxicological Review of Methanol: In Support of the Summary Information in the Integrated... listening session for the external review draft document titled ``Toxicological Review of Methanol: In... draft IRIS health assessment for methanol will be held on February 23, 2010, beginning at 9 a.m. and...

  5. Peer Review Comments on draft Topeka Shiner SSA Report - Sept 2017

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A compilation of the peer review comments on the Draft Topeka shiner SSA report. Four sets of comments were obtained from our peer review, including comments from:...

  6. [Draft] Biological review : Ouray National Wildlife refuge : 10-11 October 2001

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Draft biological review report for Ouray National Wildlife Refuge, located along the Green River near Vernal, Utah. The review focuses on historical and present...

  7. 76 FR 54228 - Draft Toxicological Review of Acrylonitrile: In Support of Summary Information on the Integrated...

    Science.gov (United States)

    2011-08-31

    ... AGENCY Draft Toxicological Review of Acrylonitrile: In Support of Summary Information on the Integrated... Acrylonitrile: In Support of Summary Information on the Integrated Risk Information System (IRIS)'' (EPA/635/R-08/013A). We are extending this notice 30 days at the request of the Acrylonitrile Group. The draft...

  8. 78 FR 65980 - Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation...

    Science.gov (United States)

    2013-11-04

    ... challenges that a changing climate poses to human health and the environment. It is essential therefore, that... health and the environment. As EPA articulated in its draft Agency Climate Change Adaptation Plan, many... AGENCY Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation...

  9. 75 FR 69065 - Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk...

    Science.gov (United States)

    2010-11-10

    ... AGENCY Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk... the draft human health assessment titled, ``Toxicological Review of Urea: In Support of Summary... workshop on the draft assessment for Urea will be held via teleconference on December 13, 2010, beginning...

  10. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    Science.gov (United States)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  11. Tracing a decade of drafting, reviewing and assessing integrated ...

    African Journals Online (AJOL)

    and post-ad hoc plan outcomes. Plan assessment is undertaken while plans are prepared (Baer, 1997: .... for advertising the draft IDP put further strain on the time frames for the com- pletion of the IDPs, hence “corners .... municipalities in a report format. These inputs had to be worked into the Draft. IDP before adoption by ...

  12. IRIS Toxicological Review of Acrylamide (External Review Draft)

    Science.gov (United States)

    EPA has conducted a peer review by EPA’s Science Advisory Board (SAB) of the scientific basis supporting the human health hazard and dose-response assessment of acrylamide that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is m...

  13. IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review of Trichloroacetic Acid (TCA), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development ...

  14. 76 FR 70151 - Draft Guidance for Industry, Clinical Investigators, Institutional Review Boards, and Food and...

    Science.gov (United States)

    2011-11-10

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry, Clinical Investigators, Institutional Review Boards, and Food and Drug Administration Staff; Food and Drug Administration Decisions for Investigational Device Exemption Clinical Investigations; Availability AGENCY: Food and Drug Administration, HHS...

  15. RE: Request for Correction - SAB Workgroup Review of Draft IRIS Assessment for Inorganic Arsenic

    Science.gov (United States)

    Request from Lynn Bergeson for the correction of information in the draft EPA document Toxicological Review of Inorganic Arsenic: In Support of the Summary Information on the Integrated Risk Information System (IRIS).

  16. IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review of Hydrogen Cyanide (HCN) and Cyanide Salts, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS As...

  17. IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review of Dichloromethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Proc...

  18. IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroacetic acid (TCA) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  19. IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft 2010)

    Science.gov (United States)

    UPDATE EPA is currently revising its Integrated Risk Information System (IRIS) assessment of formaldehyde to address the 2011 NAS peer review recommendations. This assessment addresses both noncancer and cancer human health effects that are relevant to assessing ...

  20. IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of hydrogen cyanide and cyanide salts that will appear on the Integrated Risk Information System (IRIS) database.

  1. IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Dichloromethane that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  2. IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)

    Science.gov (United States)

    EPA is seeking additional public comment and external peer review of the scientific basis supporting the human health hazard and dose-response assessment of methanol (noncancer). Teleconference Details: The public may participate in th...

  3. IRIS Toxicological Review of Methanol (External Review Draft, 2013)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  4. 77 FR 24715 - Solicitation of Written Comments on Draft: National Action Plan To Prevent Healthcare-Associated...

    Science.gov (United States)

    2012-04-25

    ... Healthcare Quality is soliciting public comment on the revised draft National Action Plan to Prevent.... Background Healthcare-associated infections, or HAIs, are a serious public health issue; at any given time... centers, end-stage renal disease facilities). The healthcare and public health communities are...

  5. 77 FR 46518 - Draft Resource Management Plan/General Plan Draft Environmental Impact Statement/Revised Draft...

    Science.gov (United States)

    2012-08-03

    ... available for public review and comment the San Luis Reservoir State Recreation Area Resource Management... Bureau of Reclamation Draft Resource Management Plan/General Plan Draft Environmental Impact Statement..., California AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of availability. SUMMARY: The Bureau of...

  6. 76 FR 21736 - Draft Toxicological Review of Methanol (Non-Cancer) in Support of Summary Information on the...

    Science.gov (United States)

    2011-04-18

    ... AGENCY Draft Toxicological Review of Methanol (Non-Cancer) in Support of Summary Information on the... Review of Methanol (Non-Cancer): In Support of Summary Information on the Integrated Risk Information... released an external peer review draft IRIS Toxicological Review for methanol (EPA/635/R-09/013...

  7. Integrated Science Assessment (ISA) for Particulate Matter (Second External Review Draft, Jul 2009)

    Science.gov (United States)

    EPA has announced that the Second External Review Draft of the Integrated Science Assessment (ISA) for Particulate Matter (PM) have been made available for independent peer review and public review. The ISA reflects the latest scientific knowledge useful in indicating the kind...

  8. 75 FR 16459 - Draft Document Related to the Review of the National Ambient Air Quality Standards for...

    Science.gov (United States)

    2010-04-01

    ... AGENCY Draft Document Related to the Review of the National Ambient Air Quality Standards for Particulate... titled, Policy Assessment for the Review of the Particulate Matter National Ambient Air Quality Standards... Particulate Matter National Ambient Air Quality Standards--First External Review Draft (March 2010), please...

  9. Integrated Science Assessment (ISA) for Oxides of Nitrogen and Sulfur - Environmental Criteria (Second External Review Draft, Aug 2008)

    Science.gov (United States)

    EPA has announced that the Second External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen and Sulfur - Environmental Criteria has been made available for independent peer review and public review. This draft ISA document represents a conci...

  10. Integrated Science Assessment (ISA) for Oxides of Nitrogen and Sulfur - Environmental Criteria (First External Review Draft, Dec 2007)

    Science.gov (United States)

    EPA is announcing that the First External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen and Sulfur – Environmental Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise ...

  11. 76 FR 67439 - External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic...

    Science.gov (United States)

    2011-11-01

    ... Microorganisms With Focus on Food and Water AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...: Pathogenic Microorganisms with Focus on Food and Water. EPA previously announced the release of the draft... Guideline: Pathogenic Microorganisms with Focus on Food and Water will be held on Monday, November 7, 2011...

  12. 75 FR 51838 - Public Review of Draft Coastal and Marine Ecological Classification Standard

    Science.gov (United States)

    2010-08-23

    ..., characterizing and naming ecological units in support of monitoring, protection, and restoration of unique biotic... and Marine Ecological Classification Standard AGENCY: Department of the Interior, U.S. Geological Survey. ACTION: Notice; request for comments on draft Coastal and Marine Ecological Classification...

  13. 77 FR 51798 - First Draft Documents Related to the Review of the National Ambient Air Quality Standards for Ozone

    Science.gov (United States)

    2012-08-27

    ... AGENCY First Draft Documents Related to the Review of the National Ambient Air Quality Standards for... of the Ozone National Ambient Air Quality Standards: First External Review Draft. The Agency is...-001; July 2012), please contact Ms. Karen Wesson, Office of Air Quality Planning and Standards (Mail...

  14. 76 FR 20347 - Release of Draft Integrated Review Plan for the National Ambient Air Quality Standards for Lead

    Science.gov (United States)

    2011-04-12

    ... AGENCY Release of Draft Integrated Review Plan for the National Ambient Air Quality Standards for Lead... National Ambient Air Quality Standards for Lead (draft IRP). This document contains the plans for the review of the air quality criteria and national ambient air quality standards (NAAQS) for lead (Pb). The...

  15. 75 FR 27838 - Notice of Availability of Draft NUREG-1800, Revision 2; “Standard Review Plan for Review of...

    Science.gov (United States)

    2010-05-18

    ... 54), as well as techniques used by the NRC staff in evaluating applications for license renewals... staff is issuing drafts of the revised NUREG-1800, ``Standard Review Plan for Review of License Renewal... (GALL) Report'' for public comment. These revised documents describe methods acceptable to the NRC staff...

  16. 76 FR 8741 - National Toxicology Program (NTP): Office of Liaison, Policy, and Review; Availability of Draft...

    Science.gov (United States)

    2011-02-15

    ... HUMAN SERVICES National Toxicology Program (NTP): Office of Liaison, Policy, and Review; Availability of... findings and conclusions of draft NTP TRs of toxicology and carcinogenesis studies in conventional or..., 2011. John R. Bucher, Associate Director, National Toxicology Program. BILLING CODE 4140-01-P ...

  17. 75 FR 73085 - National Toxicology Program (NTP): Office of Liaison, Policy, and Review; Availability of Draft...

    Science.gov (United States)

    2010-11-29

    ... HUMAN SERVICES National Toxicology Program (NTP): Office of Liaison, Policy, and Review; Availability of... findings and conclusions of draft NTP TRs of toxicology and carcinogenicity studies. The preliminary agenda... 18, 2010. John R. Bucher, Associate Director, National Toxicology Program. BILLING CODE 4140-01-P ...

  18. Basins 4.0 Climate Assessment Tool (Cat): Supporting Documentation and User Manual (External Review Draft)

    Science.gov (United States)

    EPA has released of the draft document solely for the purpose of pre-dissemination peer review under applicable Information Quality Guidelines (IQGs). This document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agenc...

  19. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from ot...

  20. 76 FR 20349 - Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the...

    Science.gov (United States)

    2011-04-12

    ... the draft assessment under review. Space is limited, and reservations will be accepted on a first... held at Hilton Crystal City Hotel; 2399 Jefferson Davis Highway; Arlington, VA 22202. To attend the... wish to make comments during the workshop. Information on Services for Individuals with Disabilities...

  1. 76 FR 55384 - External Peer Review Meeting for the Draft Guidance of Applying Quantitative Data To Develop Data...

    Science.gov (United States)

    2011-09-07

    ... AGENCY External Peer Review Meeting for the Draft Guidance of Applying Quantitative Data To Develop Data..., ``Guidance for Applying Quantitative Data to Develop Data-Derived Extrapolation Factors for Interspecies and... meeting on the draft document, ``Guidance for Applying Quantitative Data to Develop Data-Derived...

  2. 75 FR 59716 - Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk...

    Science.gov (United States)

    2010-09-28

    ... AGENCY Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk... Urea: In Support of Summary Information on the Integrated Risk Information System (IRIS)'' [EPA/ 635/R..., 2010. The listening session on the draft assessment for urea will be held on November 16, 2010...

  3. IRIS Toxicological Review of Formaldehyde (Interagency Science Consultation Draft)

    Science.gov (United States)

    On June 2, 2010, the Toxicological Review of Formaldehyde and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices...

  4. Draft safety review plan for accelerator production of tritium (APT) project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The purpose of this ``living`` Safety Review Plan (SRP) is to describe the products and processes that will be followed to conduct a systematic review of the Accelerator Production of Tritium (APT) Facility Preliminary Safety Analysis Report (PSAR), and subsequently to prepare a draft Safety Evaluation Report (SER) on the PSAR. This plan is prepared for and will be implemented by the APT Independent Safety Review Committee (ISRC) over the period July 1, 1997 through September 30, 1998, in accordance with provisions established in DOE-STD-1104-96. A core team of DOE, INEEL, and AMPARO Corporation engineers and scientists will prepare the initial draft SER with assistance from other ISRC team members on an as needed basis. Guidelines for preparing the draft SER are presented in Section 7 of this SRP. The PSAR reviews will focus exclusively on safety. The ever-present two-part question will be: Does the subject matter have safety significance? If so, does the APT structural, system, component, and/or process engineering design ensure an acceptable margin of safety? The APT mission, efficiency, and cost are not considerations of this plan. A more detailed discussion of the review philosophy is presented in Section 5 of this SRP.

  5. 76 FR 38650 - Draft Integrated Science Assessment for Lead

    Science.gov (United States)

    2011-07-01

    ... AGENCY Draft Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency. ACTION... Draft Integrated Science Assessment for Lead'' (EPA/600/R-10/075A). The original Federal Register notice... Development as part of the review of the National Ambient Air Quality Standards (NAAQS) for Lead. DATES: The...

  6. 76 FR 61704 - Availability of Draft NTP Monograph on the Health Effects of Low-Level Lead; Request for Comments...

    Science.gov (United States)

    2011-10-05

    ... HUMAN SERVICES Availability of Draft NTP Monograph on the Health Effects of Low- Level Lead; Request for Comments; Announcement of a Panel Meeting to Peer Review Draft Monograph AGENCY: Division of the National... of Health. ACTION: Availability of Draft NTP Monograph; Request for Comments; Announcement of a Peer...

  7. 76 FR 55391 - Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of...

    Science.gov (United States)

    2011-09-07

    ... HUMAN SERVICES Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy During Pregnancy and Panel Meeting To Peer Review Draft Monograph AGENCY... (NIEHS), National Institutes of Health. ACTION: Notice of postponement of draft NTP monograph and peer...

  8. Development of a draft of human factors safety review procedures for the Korean next generation reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Woon; Moon, B. S.; Park, J. C.; Lee, Y. H.; Oh, I. S.; Lee, H. C. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-02-01

    In this study, a draft of human factors engineering (HFE) safety review procedures (SRP) was developed for the safety review of KNGR based on HFE Safety and Regulatory Requirements and Guidelines (SRRG). This draft includes acceptance criteria, review procedure, and evaluation findings for the areas of review including HFE Program Management, Human Factors Analyses, Human Factors Design, and HFE Verification and Validation, based on Section 15.1 'Human Factors Engineering Design Process' and 15.2 'Control Room Human Factors Engineering' of KNGR Specific Safety Requirements and Chapter 15 'Human Factors Engineering' of KNGR Safety Regulatory Guides. For the effective review, human factors concerns or issues related to advanced HSI design that have been reported so far should be extensively examined. In this study, a total of 384 human factors issues related to the advanced HSI design were collected through our review of a total of 145 documents. A summary of each issue was described and the issues were identified by specific features of HSI design. These results were implemented into a database system. 8 refs., 2 figs. (Author)

  9. 77 FR 56202 - Notification of an External Peer Review Meeting for the Draft Framework for Human Health Risk...

    Science.gov (United States)

    2012-09-12

    ... contractor to the EPA, will convene an independent panel of experts to review the draft document, Framework... formalize and implement planning, scoping and problem formulation early in the risk assessment process and... emphasizes the importance of both scientific review and public involvement. The Framework presents the...

  10. 77 FR 74175 - Solicitation of Review Editors for the Draft Report of the National Climate Assessment and...

    Science.gov (United States)

    2012-12-13

    ... National Oceanic and Atmospheric Administration RIN 0648-XC384 Solicitation of Review Editors for the Draft... editors of the National Climate Assessment and Development Advisory Committee (NCADAC) National Climate... Review Editors of the National Climate Assessment and Development Advisory Committee (NCADAC) National...

  11. The process of consensus on EMF: SAB review of the EPA draft document on EMF and cancer

    Science.gov (United States)

    Wilson, B. W.

    1992-06-01

    The EPA Draft Document on EMF and Cancers grew out of an earlier effort by EPA to track biological effects literature relative to radio-frequency (RF) exposure. Scope of the document was broadened to include extremely low frequency electric and magnetic fields prior to an announcement in 1986 that EPA would formally review the whole area of non-ionizing radiation. An extensive survey of the relevant bioeffects and epidemiologic literature was carried out, and writing on the document began in earnest on the document sometime in 1989. In its draft form, the document reviewed the literature on mechanisms of Interaction between electromagnetic fields and biological tissue, EMF epidemiologic studies, supporting evidence for carcinogenicity and research needs. In the early summer of 1990, a draft of the document was reviewed by some 22 individuals within the EPA and other government agencies. It was also sent out for external review to an additional 9 qualified scientists who had worked in the area and were familiar with EMF-related literature in epidemiology, biology, and physics. Many of the comments sent to EPA from this first review, prior to release of the draft for public comment, were strikingly similar to those resulting from the second (public) review process. Thus, it appears that much of the controversy that was later associated with the document could have been avoided had the authors been diligent in following the recommendations of the initial set of reviewers.

  12. 76 FR 60055 - Draft Guidance for Industry: Applications for Premarket Review of New Tobacco Products...

    Science.gov (United States)

    2011-09-28

    ...), as amended by the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act). The draft.... Background FDA is announcing the availability of a draft guidance entitled ``Applications for Premarket...

  13. 77 FR 66626 - Deepwater Horizon Oil Spill; Draft Early Restoration Plan and Environmental Review

    Science.gov (United States)

    2012-11-06

    ... Assessment (Phase I ERP/EA) in April 2012. The Phase I ERP is currently being implemented. In a continuation... to satisfy claims against BP. Overview of the Draft ERP/ER Draft Early Restoration Plan Alternatives, Including Our Proposed Alternative The Draft ERP/ER is being released in accordance with the Oil Pollution...

  14. 75 FR 34736 - Draft FY 2011-2015 EPA Strategic Plan

    Science.gov (United States)

    2010-06-18

    ... AGENCY Draft FY 2011-2015 EPA Strategic Plan AGENCY: Environmental Protection Agency. ACTION: Notice of... announcing the availability of the Draft FY 2011-2015 EPA Strategic Plan (Strategic Plan) for public review... (GPRA). The Agency's final ] Strategic Plan will be submitted to Congress by September 30, 2010. The...

  15. 78 FR 56271 - FY 2014-2020 Draft VA Strategic Plan

    Science.gov (United States)

    2013-09-12

    ... AFFAIRS FY 2014-2020 Draft VA Strategic Plan AGENCY: Department of Veterans Affairs. ACTION: Notice of... availability of the FY 2014-2020 Draft VA Strategic Plan (Strategic Plan) for public review and comment, as..., and leadership to meet our clients' needs and expectations. DATES: Comments must be received by VA on...

  16. 78 FR 26616 - Draft NOAA Five Year Research and Development Plan

    Science.gov (United States)

    2013-05-07

    ... NOAA Five Year Research and Development Plan AGENCY: National Oceanic and Atmospheric Administration (NOAA), Department of Commerce (DOC). ACTION: Draft NOAA Five Year Research and Development Plan for Public Review. SUMMARY: NOAA's draft Five Year Research and Development Plan is available for public...

  17. 78 FR 63464 - Notice of Extension of the Public Comment Period on the Draft Toxicological Review of Benzo[a...

    Science.gov (United States)

    2013-10-24

    ... IRIS toxicity values with exposure information to characterize public health risks of chemical...: In Support of the Summary Information on the Integrated Risk Information System (IRIS) and the... Information on the Integrated Risk Information System (IRIS)'' (EPA/635/R-13/138) and the draft peer review...

  18. 76 FR 4115 - Request for the Technical Review of the Draft Current Intelligence Bulletin (CIB): Derivation of...

    Science.gov (United States)

    2011-01-24

    ... Current Intelligence Bulletin (CIB): Derivation of Immediately Dangerous to Life and Health (IDLH) Values... Disease Control and Prevention (CDC) is conducting a public review of the draft, Current Intelligence Bulletin (CIB): Derivation of Immediately Dangerous to Life and Health (IDLH) Values. NIOSH is requesting...

  19. 78 FR 9387 - Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation Plan

    Science.gov (United States)

    2013-02-08

    ... challenges that a changing climate poses to human health and the environment. It is essential; therefore... mission of protecting human health and the environment even as the climate changes. EPA considers public... AGENCY Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation Plan...

  20. Canadian support for population stabilization. The Rome draft Plan of Action. Dr. Jean Augustine, MP (Canada).

    Science.gov (United States)

    1996-01-01

    Canada strongly believes in the central role to be played by the civil sector in the process leading to the World Food Summit. Dr. Augustine, Member of Parliament of Canada, described how the Canadian Government involved 350 national organizations over an eight-month period in the creation of the country's official position on food security. Canada has also negotiated with several other countries and international organizations on issues such as trade, human rights, the right to food, and follow-up to the Plan of Action. Dr. Augustine summarized Canada's 18 priorities for the World Food Summit. The priorities include human rights and good governance; poverty reduction; peace, security and conflict resolution; national responsibility for food security; national and global partnerships; nutrition and health; human resource development; gender equity; population stabilization; trade liberalization; agricultural adjustment to international markets; post-harvest marketing and food marketing; the role of the private sector; capacity building; environment and sustainable production; and research and technology transfer.

  1. From Systematic Review to Call for Action.

    Science.gov (United States)

    Sawin, Erika Metzler; Sobel, Linda L; Annan, Sandra L; Schminkey, Donna L

    2017-06-01

    Intimate partner violence (IPV) is a global public health and criminal justice concern with significant impacts; especially high rates are seen among rural Hispanic American (HA) communities, the fastest growing population in the United States. They experience additional barriers to care including extreme poverty, lesser education, gender norms, and language and immigration issues. A systematic literature review was conducted using Cooper's framework to identify evidence supporting associations between interventions and prevention, reduction, and elimination of IPV among rural HA women. Searches conducted on databases including CINAHL, PubMed, Medline, Women's Studies International, MedicLatina, and JSTOR used the MeSH terms Hispanic Americans (Latino/a and Hispanic), domestic violence, and intimate partner violence. Selected studies were published between January 1, 2000, and January 1, 2014. Of the 617 yielded articles, only 6 met the inclusion criteria. Of these, none closely examined rurality or provided valid and reliable measures of outcomes, instead reporting program descriptions and suggested interventions. We identify key findings to guide program, screening, and tool development. Our study identifies a gap in knowledge, research, and effective practices and issues a call for action to create evidence-based tools to prevent, reduce, and eliminate IPV in these underserved populations.

  2. 78 FR 42086 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    Science.gov (United States)

    2013-07-15

    ... and achievable with the use of good manufacturing practices. It also describes FDA's intended sampling... to be protective of human health and to be achievable with the use of good manufacturing practices... with FDA's good guidance practices regulation (21 CFR 10.115). The draft guidance, when finalized, will...

  3. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (External Review Draft)

    Science.gov (United States)

    EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene glycol monobutyl ether that will appear on the Integrated Risk Information System (IRIS) database.

  4. IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  5. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Science.gov (United States)

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  6. Review: Ernest T. Stringer (2007. Action Research

    Directory of Open Access Journals (Sweden)

    Tobias Denskus

    2008-10-01

    Full Text Available STRINGER's book on action research provides an accessible introduction to conducting participatory inquiries for social change. This general overview of the theoretical foundations of action research and methodological challenges is enriched by practical examples, insights, and exercises that are based on the author's substantial experience as a researcher and practitioner. Students and teachers will find this a valuable resource for teaching and training. However, STRINGER's positive outlook on humanity and communities and his non-confrontational style of action research ignores some of the "darker" sides of power, knowledge, and the difficulties of achieving sustainable social change. The final chapter and substantial appendices have a strong focus on traditional report writing; more alternative case studies on how to communicate action research may have been useful to balance his more conventional project-management approach. Overall, this is a very good introductory volume that can spark ideas, discussions, and (self- reflection on how to better link theory and practice. URN: urn:nbn:de:0114-fqs0901108

  7. Nursing resistance as ethical action: literature review.

    Science.gov (United States)

    Peter, Elizabeth; Lunardi, Valeria Lerch; Macfarlane, Amy

    2004-05-01

    Much has been written about nursing as a predominantly female profession whose members display passivity, submission, obedience and powerlessness. Alternatively, some authors have presented evidence of nurses' capacity to exercise power, revealing the possible relationship between powerlessness and ethical compromise. Thus, empowerment strategies for nurses can yield ethical action. The aim of this paper is to use analysis of the literature to demonstrate how the actions and responses of nurses to ethical concerns are examples of nurses exercising power. Empirical studies published in the nursing literature between 1990 and 2003 have been analysed to illustrate how nurses' actions of resistance can ensure that moral values are realized in practice. Foucauldian notions of power relations and feminist ethics provide the theoretical framework. Nurses were found to resist in situations where they experienced moral conflicts in relation to the actions of health professionals; however, instances were cited where they did not. Consequently, strategies for nursing education and management are proposed to increase nurses' understanding of the potential acts of resistance that they could employ in situations of moral conflict or concern.

  8. Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray (External Review Draft)

    Science.gov (United States)

    This draft document presents a case study of engineered nanoscale silver (nano-Ag), focusing on the specific example of nano-Ag as possibly used in disinfectant sprays. This case study is organized around a comprehensive environmental assessment (CEA) framework, which combines a ...

  9. BASINS and WEPP Climate Assessment Tools (CAT): Case Study Guide to Potential Applications (External Review Draft)

    Science.gov (United States)

    This draft report supports application of two recently developed water modeling tools, the BASINS and WEPP climate assessment tools. The report presents a series of short case studies designed to illustrate the capabilities of these tools for conducting scenario based assessments...

  10. Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria (Second External Review Draft, 2015)

    Science.gov (United States)

    This draft document provides EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of oxides of nitrogen. When final, it will provide a critical part of the scientific foundation for EPA’s decision regarding the adequacy of the current ...

  11. Corrective Action Investigation Plan for Corrective Action Unit 556: Dry Wells and Surface Release Points Nevada Test Site, Nevada (Draft), Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Grant Evenson

    2007-02-01

    Corrective Action Unit  (CAU) 556, Dry Wells and Surface Release Points, is located in Areas 6 and 25 of the Nevada Test Site, 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 556 is comprised of four corrective action sites (CASs) listed below: •06-20-04, National Cementers Dry Well •06-99-09, Birdwell Test Hole •25-60-03, E-MAD Stormwater Discharge and Piping •25-64-01, Vehicle Washdown and Drainage Pit These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  12. Towards new educational potentialities: Review and commentary of the Preliminary draft Act on higher education

    Directory of Open Access Journals (Sweden)

    Madžar Ljubomir

    2005-01-01

    Full Text Available The Higher Education Act is a long-awaited legal act. A number of uncompleted attempts to prepare it have been undertaken in the course of the last three years. So far without success. Having been and still being a matter of highest social priority, the renewed effort to create and subsequently to enact this act is welcome as a worthwhile and a highly productive endeavor. Welcome also are the main innovations offered by this act, particularly its conspicuous consistency with the Bologna Declaration and other internationally launched and accepted documents. The draft act follows the international documents tracing down the paths of the future development of the educational systems of the European countries and providing for their mutual compatibility. A number of other positive contributions of the draft act are singled out, such as introducing clear and rigorous criteria and procedures for accreditation and quality control, introducing a wide coverage of arts and sciences as a precondition for an institution of higher education to qualify as a university, flexibility in the regime of studying including the domestic and international mobility of the students and requirement for the schools of higher education to have large cores of permanently employed teaching staff. A much larger part of the paper is, however, devoted to critical commentaries. To begin with, the draft is produced without any participation of the private universities, which is seen as a form of discrimination. The organizational pattern of a university is laid out with insufficient clarity and the status of departments (faculties is particularly short of precision and even contradictory. The draft seems to be laden with the old bias towards excessive and potentially disastrous centralization, drastically reducing the decision making capacity of the system. The treatment of the property of the departments (faculties is found inconsistent and legally unfounded. Inconsistency is

  13. Nanomaterial Case Study: A Comparison of Multiwalled Carbon Nanotube and Decabromodiphenyl Ether Flame-Retardant Coatings Applied to Upholstery Textiles (Independent Peer Review Draft)

    Science.gov (United States)

    This Independent Peer Review Draft document presents a case study of multiwalled carbon nanotubes (MWCNTs); it focuses on the specific example of MWCNTs as used in flame-retardant coatings applied to upholstery textiles. This case study is organized around the comprehensive envir...

  14. 75 FR 9613 - Draft NIJ Restraints Standard for Criminal Justice

    Science.gov (United States)

    2010-03-03

    ... industry technical representatives, criminal justice agencies and organizations, research, development and... of Justice Programs Draft NIJ Restraints Standard for Criminal Justice AGENCY: National Institute of Justice, Office of Justice Programs, DOJ. ACTION: Notice of Draft NIJ Restraints Standard for Criminal...

  15. 75 FR 28073 - Draft Regulatory Guide: Issuance, Availability

    Science.gov (United States)

    2010-05-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-3039, ``Standard Format and Content for...

  16. 76 FR 17646 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions...

    Science.gov (United States)

    2011-03-30

    ... adverse human health impacts or environmental effects from exposure to the pesticide(s) discussed in this... AGENCY Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions, and... has established registration review dockets for the ] pesticides listed in the table in Unit III.A...

  17. Radioactive waste isolation in salt: Peer review of the Golder Associates draft test plan for in situ testing in an exploratory shaft in salt

    Energy Technology Data Exchange (ETDEWEB)

    Hambley, D.F.; Mraz, D.Z.; Unterberter, R.R.; Stormont, J.C.; Neuman, S.P.; Russell, J.E.; Jacoby, C.H.; Hull, A.B.; Brady, B.H.G.; Ditmars, J.D.

    1987-01-01

    This report documents the peer review conducted by Argonne National Laboratory of a document entitled ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared for Battelle Memorial Institute's Office of Nuclear Waste Isolation by Golder Associates, Inc. In general, the peer review panelists found the test plan to be technically sound, although some deficiencies were identified. Recommendations for improving the test plan are presented in this review report. A microfiche copy of the following unpublished report is attached to the inside back cover of this report: ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared by Golder Associates, Inc., for Office of Nuclear Waste Isolation, Battelle Memorial Institute, Columbus, Ohio (March 1985).

  18. 76 FR 38166 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    Science.gov (United States)

    2011-06-29

    ... residues that result from the use of a pesticide in or on food. III. Registration Reviews A. What action is...) 305- 6785, [email protected] . Permethrin, 2510 EPA-HQ-OPP-2011-0039 Kaitlin Keller, (703...

  19. Remedial action plan for the inactive Uranium Processing Site at Naturita, Colorado. Remedial action plan: Attachment 2, Geology report, Attachment 3, Ground water hydrology report: Working draft

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    The uranium processing site near Naturita, Colorado, is one of 24 inactive uranium mill sites designated to be cleaned up by the US Department of Energy (DOE) under the Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), 42 USC {section}7901 et seq. Part of the UMTRCA requires that the US Nuclear Regulatory Commission (NRC) concur with the DOE`s remedial action plan (RAP) and certify that the remedial action conducted at the site complies with the standards promulgated by the US Environmental Protection Agency (EPA). This RAP serves two purposes. First, it describes the activities that are proposed by the DOE to accomplish remediation and long-term stabilization and control of the radioactive materials at the inactive uranium processing site near Naturita, Colorado. Second, this RAP, upon concurrence and execution by the DOE, the state of Colorado, and the NRC, become Appendix B of the cooperative agreement between the DOE and the state of Colorado.

  20. EPA scientific integrity policy draft

    Science.gov (United States)

    Showstack, Randy

    2011-08-01

    The U.S. Environmental Protection Agency (EPA) issued its draft scientific integrity policy on 5 August. The draft policy addresses scientific ethical standards, communications with the public, the use of advisory committees and peer review, and professional development. The draft policy was developed by an ad hoc group of EPA senior staff and scientists in response to a December 2010 memorandum on scientific integrity from the White House Office of Science and Technology Policy. The agency is accepting public comments on the draft through 6 September; comments should be sent to osa.staff@epa.gov. For more information, see http://www.epa.gov/stpc/pdfs/draft-scientific-integrity-policy-aug2011.pdf.

  1. Environmental assessment of remedial action at the Slick Rock uranium mill tailings sites Slick Rock, Colorado. Draft

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-06-01

    The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA) authorized the US Department of Energy (DOE) to clean up two uranium mill tailings processing sites near Slick Rock, Colorado, in San Miguel County. The purpose of the cleanup is to reduce the potential health effects associated with the radioactive materials remaining on the sites and on vicinity properties (VP) associated with the sites. The US Environmental Protection Agency (EPA) promulgated standards for the UMTRCA that contained measures to control the contaminated materials and to protect the groundwater from further degradation. Remedial actions at the Slick Rock sites must be performed in accordance with these standards and with the concurrence of the US Nuclear Regulatory Commission (NRC).

  2. North Mississippi Refuges Complex Biological Program 'Pulse-Check' Review - DRAFT REPORT

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Biological review for the three refuges of the North Mississippi Refuges Complex is presented. Review is based on an assessment of addressing goals and objectives...

  3. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 8: Aerothermodynamics Automation and Robotics (A/R) systems sensors, high-temperature superconductivity

    Science.gov (United States)

    1991-01-01

    Viewgraphs of briefings presented at the SSTAC/ARTS review of the draft Integrated Technology Plan (ITP) on aerothermodynamics, automation and robotics systems, sensors, and high-temperature superconductivity are included. Topics covered include: aerothermodynamics; aerobraking; aeroassist flight experiment; entry technology for probes and penetrators; automation and robotics; artificial intelligence; NASA telerobotics program; planetary rover program; science sensor technology; direct detector; submillimeter sensors; laser sensors; passive microwave sensing; active microwave sensing; sensor electronics; sensor optics; coolers and cryogenics; and high temperature superconductivity.

  4. Draft Statement of Work / Performance Work Statement SOL-R3-13-00006: Region 3 - National Remedial Action Contracts / Multiple Award Competition

    Science.gov (United States)

    Region 3 - EPA is performing market research to determine if industry has the capability and capacity to perform the work, on a national level, as described in the attached draft Statement of Work /Performance Work Statement(SOW/PWS).

  5. Review Essay: Getting with the Act of Action Research

    Directory of Open Access Journals (Sweden)

    Victoria J. Palmer

    2009-07-01

    Full Text Available Action research (AR prides itself on being a field of both theoretical and practical inquiry. Its scholarly identity rests heavily on framing participants as engaged, subjective, and participatory beings who learn and change through research processes. Yet, action research struggles to be considered a rigorous methodological field of inquiry and certainly there have been those who have raised questions about its validity as a research method. Where action research is used, qualifications and justifications abound as people struggle to have their research heard over other disciplines and techniques that claim more validity or appropriateness of methods. As a community development practitioner, I have employed AR approaches in the design and application of projects. As an academic, I have had the opportunity to design and facilitate meetings using participatory action research methods for data collection and to develop ground-up interventions with primary health care professionals. Therefore, I was eager to read about AR theoretical developments and to examine this text for its core purpose: as a "handbook" to guide research and practice. The handbook boasts 32 chapters covering theory, practices, exemplars, and skills which I reviewed with particular attention to where, how, and why I would use the content and whether it offered what a research handbook should—practical assistance in design, application, analysis, and synthesis for AR. Overall, the handbook does provide extensive examples about research projects and process. In future editions though, I would like to see more attention to complementary methods that can be employed in AR and attention to methods for the analysis of data generated via action research approaches. URN: urn:nbn:de:0114-fqs0903268

  6. Drafting Fundamentals. Drafting Module 1. Instructor's Guide.

    Science.gov (United States)

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. The guide contains a cross-reference table of instructional materials. Ten units cover drafting fundamentals: (1) introduction to drafting; (2) general safety;…

  7. A study of the review and comment phase of the environmental impact statement : draft and negative.

    Science.gov (United States)

    1972-01-01

    This study examined the agencies that review the environmental impact statements (EIS) prepared on highway projects and was an attempt to shed light on the functions, personnel, and problems of the offices that saw the statements. The report covered ...

  8. 75 FR 2107 - Notice of Availability of the Draft Environmental Assessment (Draft EA) for the Urban Stream...

    Science.gov (United States)

    2010-01-14

    ... opportunities for the public and other groups. The grant recipient, DuPage County Stormwater Management Division... Assessment (Draft EA) for the Urban Stream Research Center Proposed To Be Constructed in Unincorporated...), Commerce. ACTION: Notice of Availability of the Draft Environmental Assessment (Draft EA) for the Urban...

  9. Review and assessments of potential environmental, health and safety impacts of MHD technology. Final draft

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    The purpose of this document is to develop an environmental, health and safety (EH and S) assessment and begin a site - specific assessment of these and socio - economic impacts for the magnetohydrodynamics program of the United States Department of Energy. This assessment includes detailed scientific and technical information on the specific EH and S issues mentioned in the MHD Environmental Development Plan. A review of current literature on impact-related subjects is also included. This document addresses the coal-fired, open-cycle MHD technology and reviews and assesses potential EH and S impacts resulting from operation of commercially-installed technology.

  10. 75 FR 29534 - Inorganic Nitrates-Nitrite, Carbon and Carbon Dioxide, and Sulfur Registration Review; Draft...

    Science.gov (United States)

    2010-05-26

    ...] [FR Doc No: 2010-12591] ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0434; FRL-8826-6] Inorganic... ecological risk assessment for the registration review of inorganic nitrates - nitrites, carbon and carbon... inorganic nitrates- nitrites, carbon and carbon dioxide uses, as well as gas cartridge uses of sulfur. The...

  11. 75 FR 1790 - Draft Guidance for Institutional Review Boards, Clinical Investigators, and Sponsors: IRB...

    Science.gov (United States)

    2010-01-13

    ... review responsibility by providing recommendations regarding the criteria, process, and frequency of... Communication, Outreach and Development (HFM-40), Center for Biologics Evaluation and Research (CBER), Food and...-827-1800); or the Division of Small Manufacturers, International, and Consumer Assistance, Center for...

  12. 78 FR 13686 - Draft Guidance for Industry and Review Staff on Pediatric Information Incorporated Into Human...

    Science.gov (United States)

    2013-02-28

    ... is intended to assist applicants and FDA review staff in making decisions about the placement and... amended by the Food and Drug Administration Safety and Innovation Act (FDASIA), as well as FDA... guidance before it begins work on the final version of the guidance, submit either electronic or written...

  13. Leadership training in health care action teams: a systematic review.

    Science.gov (United States)

    Rosenman, Elizabeth D; Shandro, Jamie R; Ilgen, Jonathan S; Harper, Amy L; Fernandez, Rosemarie

    2014-09-01

    To identify and describe the design, implementation, and evidence of effectiveness of leadership training interventions for health care action (HCA) teams, defined as interdisciplinary teams whose members coordinate their actions in time-pressured, unstable situations. The authors conducted a systematic search of the PubMed/MEDLINE, CINAHL, ERIC, EMBASE, PsycINFO, and Web of Science databases, key journals, and review articles published through March 2012. They identified peer-reviewed English-language articles describing leadership training interventions targeting HCA teams, at all levels of training and across all health care professions. Reviewers, working in duplicate, abstracted training characteristics and outcome data. Methodological quality was evaluated using the Medical Education Research Study Quality Instrument (MERSQI). Of the 52 included studies, 5 (10%) focused primarily on leadership training, whereas the remainder included leadership training as part of a larger teamwork curriculum. Few studies reported using a team leadership model (2; 4%) or a theoretical framework (9; 17%) to support their curricular design. Only 15 studies (29%) specified the leadership behaviors targeted by training. Forty-five studies (87%) reported an assessment component; of those, 31 (69%) provided objective outcome measures including assessment of knowledge or skills (21; 47%), behavior change (8; 18%), and patient- or system-level metrics (8; 18%). The mean MERSQI score was 11.4 (SD 2.9). Leadership training targeting HCA teams has become more prevalent. Determining best practices in leadership training is confounded by variability in leadership definitions, absence of supporting frameworks, and a paucity of robust assessments.

  14. Human-system interface design review guideline: The development of draft revision 1 to NUREG-0700

    Energy Technology Data Exchange (ETDEWEB)

    O`Hara, J.; Stubler, W.; Brown, W. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1996-03-01

    Advanced human-system interface (HSI) technologies are being developed in the commercial nuclear power industry. These HSIs may have significant implications for plant safety in that they will affect the ways in which the operator interacts with and supervises an increasingly complex system. The U.S. Nuclear Regulatory Commission (NRC) reviews the HSI aspects of nuclear plants to ensure that operator performance and reliability are supported. The NRC is developing guidance to support its review of these advanced designs. The guidance consists of an evaluation methodology and an extensive set of human factors guidelines which are used in one aspect of the evaluation. The paper describes the guidance development of the evaluation methodology and the guidelines.

  15. Implementation Plan for the Hawaii Geothermal Project Environmental Impact Statement (DOE Review Draft:)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-09-18

    The US Department of Energy (DOE) is preparing an Environmental Impact Statement (EIS) that identifies and evaluates the environmental impacts associated with the proposed Hawaii Geothermal Project (HGP), as defined by the State of Hawaii in its 1990 proposal to Congress (DBED 1990). The location of the proposed project is shown in Figure 1.1. The EIS is being prepared pursuant to the requirements of the National Environmental Policy Act of 1969 (NEPA), as implemented by the President's Council on Environmental Quality (CEQ) regulations (40 CFR Parts 1500-1508) and the DOE NEPA Implementing Procedures (10 CFR 1021), effective May 26, 1992. The State's proposal for the four-phase HGP consists of (1) exploration and testing of the geothermal resource beneath the slopes of the active Kilauea volcano on the Island of Hawaii (Big Island), (2) demonstration of deep-water power cable technology in the Alenuihaha Channel between the Big Island and Mau, (3) verification and characterization of the geothermal resource on the Big Island, and (4) construction and operation of commercial geothermal power production facilities on the Big Island, with overland and submarine transmission of electricity from the Big Island to Oahu and possibly other islands. DOE prepared appropriate NEPA documentation for separate federal actions related to Phase 1 and 2 research projects, which have been completed. This EIS will consider Phases 3 and 4, as well as reasonable alternatives to the HGP. Such alternatives include biomass coal, solar photovoltaic, wind energy, and construction and operation of commercial geothermal power production facilities on the Island of Hawaii (for exclusive use on the Big Island). In addition, the EIs will consider the reasonable alternatives among submarine cable technologies, geothermal extraction, production, and power generating technologies; pollution control technologies; overland and submarine power transmission routes; sites reasonably suited to

  16. State of Georgia Appeals Council Request for Review Actions 2009 - 2014

    Data.gov (United States)

    Social Security Administration — This report contains the number of requests for review (RR) actions taken by the Appeals Council (AC) during the period indicated. These numbers of AC actions are...

  17. 76 FR 50483 - Draft Guidance for Industry and Food and Drug Administration Staff; Factors to Consider When...

    Science.gov (United States)

    2011-08-15

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Factors to Consider When Making Benefit-Risk Determinations in Medical Device Premarket Review; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug...

  18. 75 FR 12736 - Notice of Reopening of Comment Period for the Draft Environmental Impact Statement for the Silver...

    Science.gov (United States)

    2010-03-17

    ... the Silver Strand Training Complex AGENCY: Department of the Navy, DoD. ACTION: Notice. SUMMARY: A... (75 FR 3730) on January 22, 2010, for the Silver Strand Training Complex (SSTC) Draft Environmental Impact Statement (EIS). The public review period ended on March 8, 2010. This notice announces the...

  19. 78 FR 2394 - Release of Draft Document Related to the Review of the National Ambient Air Quality Standards for...

    Science.gov (United States)

    2013-01-11

    ... Planning and Standards (Mail code C504-06), U.S. Environmental Protection Agency, Research Triangle Park..., revision of existing air quality criteria. The revised air quality criteria reflect advances in scientific... information presented in the third draft Integrated Science Assessment for Lead \\2\\ and health and ecological...

  20. 77 FR 40037 - Notice of the Peer Review Meeting for EPA's Draft Report Entitled An Assessment of Potential...

    Science.gov (United States)

    2012-07-06

    ... comments on the draft assessment. Members of the public who have registered in advance to provide oral... to determine the significance of Bristol Bay's ecological resources and evaluate the potential... wildlife ecology. Dr. Gordon Reeves, USDA Pacific NW Research Station--Expertise in fisheries biology and...

  1. 76 FR 60827 - Draft Toxicological Review of Biphenyl: In Support of Summary Information on the Integrated Risk...

    Science.gov (United States)

    2011-09-30

    ...) within the EPA Office of Research and Development (ORD). EPA is releasing this draft assessment solely... will need audio-visual equipment (e.g., laptop computer and slide projector). In general, each... EPA's IRIS is a human health assessment program that evaluates quantitative and qualitative risk...

  2. 77 FR 69920 - Notice of Availability for Public Review of the Draft Tier 1 Environmental Impact Statement for...

    Science.gov (United States)

    2012-11-21

    ... environmental impacts of the alternatives considered, including the no-build alternative. DATES: Written... Environmental Impact Statement for the Chicago, IL, to Omaha, NE, Regional Passenger Rail System Study AGENCY... availability of draft environmental impact statement. SUMMARY: FRA is issuing this Notice to advise the public...

  3. Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment (External Review Draft)

    Science.gov (United States)

    This draft report provides an overview of the types of mechanisms underlying the lymphohematopoietic cancers induced by chemical agents and radiation in humans, with a primary emphasis on leukemia and leukemia-inducing agents. It focuses on how mechanistic information on human l...

  4. 75 FR 18205 - Notice of Peer Review Meeting for the External Peer Review Drafts of Two Documents on Using...

    Science.gov (United States)

    2010-04-09

    ... announcing that Eastern Research Group, Inc. (ERG), an EPA contractor for external scientific peer review... decision process, but also to encourage their further implementation in human, ecological, and... advance EPA risk assessment science, but will also help to address specific challenges faced by managers...

  5. Policy Assessment for the Review of the Primary National Ambient Air Quality Standard for Sulfur Oxides, External Review Draft

    Science.gov (United States)

    Sulfur oxides are one of the six major air pollutants for which EPA has issued air quality criteria and established national ambient air quality standards (NAAQS) based on those criteria. The Clear Air Act (CAA) requires EPA to periodically review and revise, as appropriate, exis...

  6. Development of Action Research in China: Review and Reflection

    Science.gov (United States)

    Zhou, Jun; Liu, Katrina Yan

    2011-01-01

    Action research in China during late 1970s and 1980s was influenced by positivist scientific research, believing the purpose of doing action research is to explore the general law of education. It was carried out through educational experimentations emphasizing the control of the experimental conditions. Starting from 1990s, action research in…

  7. 76 FR 9210 - Draft DOC National Aquaculture Policy

    Science.gov (United States)

    2011-02-16

    ... DOC National Aquaculture Policy AGENCY: Commerce. ACTION: Notice of availability of draft aquaculture... draft national aquaculture policy that supports sustainable aquaculture in the United States. The intent of the policy is to guide DOC's actions and decisions on aquaculture and to provide a national...

  8. Stimulatory Action of Cyclooxygenase Inhibitors on Hematopoiesis: A Review

    Directory of Open Access Journals (Sweden)

    Lenka Weiterová

    2012-05-01

    Full Text Available The presented review summarizes experimental data obtained with a mouse model when investigating the relationship between inhibition of prostaglandin production and hematopoiesis. While prostaglandin E2 acts in a negative feedback control of myelopoiesis, inhibition of cyclooxygenases, responsible for its production, shifts the feedback to positive control. Based on these relationships, agents inhibiting cyclo-oxygenases, known as non-steroidal anti-inflammatory drugs (NSAIDs, can activate hematopoiesis and be protective or curative under myelosuppressive states. The effectiveness of therapeutic use of NSAIDs in these situations is expressive especially under the selective inhibition of cyclooxygenase-2 (COX-2, when undesirable side effects of cyclooxygenase-1 inhibition, like gastrointestinal damage, are absent. The effects of the clinically approved selective COX-2 inhibitor, meloxicam, were investigated and demonstrated significant hematopoiesis-stimulating and survival-enhancing actions of this drug in sublethally or lethally γ-irradiated mice. These effects were connected with the ability of meloxicam to increase serum levels of the granulocyte colony-stimulating factor. It can be inferred from these findings that selective COX-2 inhibitors might find their use in the treatment of myelosuppressions of various etiologies.

  9. Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review

    Directory of Open Access Journals (Sweden)

    Sin-Yeang Teow

    2016-01-01

    Full Text Available Curcumin, the major constituent of Curcuma longa L. (Zingiberaceae family or turmeric, commonly used for cooking in Asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. Curcumin is found to be effective against Staphylococcus aureus (S. aureus. As demonstrated by in vitro experiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. Hence, curcumin which is a natural product derived from plant is believed to have profound medicinal benefits and could be potentially developed into a naturally derived antibiotic in the future. However, there are several noteworthy challenges in the development of curcumin as a medicine. S. aureus infections, particularly those caused by the multidrug-resistant strains, have emerged as a global health issue and urgent action is needed. This review focuses on the antibacterial activities of curcumin against both methicillin-sensitive S. aureus (MSSA and methicillin-resistant S. aureus (MRSA. We also attempt to highlight the potential challenges in the effort of developing curcumin into a therapeutic antibacterial agent.

  10. 76 FR 66311 - Draft Documents To Support Submission of an Electronic Common Technical Document; Availability

    Science.gov (United States)

    2011-10-26

    ... HUMAN SERVICES Food and Drug Administration Draft Documents To Support Submission of an Electronic Common Technical Document; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... the following draft versions of documents that support making regulatory submissions in electronic...

  11. 75 FR 41452 - Draft Guidance, “Federal Greenhouse Gas Accounting and Reporting”

    Science.gov (United States)

    2010-07-16

    ... QUALITY Draft Guidance, ``Federal Greenhouse Gas Accounting and Reporting'' AGENCY: Council on Environmental Quality. ACTION: Notice of Availability, Draft Guidance, ``Federal Greenhouse Gas Accounting and... Leadership in Environmental, Energy, and Economic Performance (74 FR 52117) in order to establish an...

  12. 7 CFR 25.300 - USDA action and review of nominations for designation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false USDA action and review of nominations for designation. 25.300 Section 25.300 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Designation Process § 25.300 USDA action and review of nominations for designation. (a...

  13. 21 CFR 10.45 - Court review of final administrative action; exhaustion of administrative remedies.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Court review of final administrative action; exhaustion of administrative remedies. 10.45 Section 10.45 Food and Drugs FOOD AND DRUG ADMINISTRATION... Administrative Procedures § 10.45 Court review of final administrative action; exhaustion of administrative...

  14. Action Research in Graduate Teacher Education: A Review of the Literature 2000-2015

    Science.gov (United States)

    Vaughan, Michelle; Burnaford, Gail

    2016-01-01

    This review explores the goals and challenges as well as the policy and programmatic implications of action research in graduate teacher education as evidenced in the published literature. This literature review looks specifically at how action research is being used in graduate teacher education programs as a content area and as a methodology in…

  15. Review of the draft law of direct elections to the parliament of southern common market: the attempt of institutional improvement on economic integration

    Directory of Open Access Journals (Sweden)

    Martinho Martins Botelho

    2016-02-01

    Full Text Available The present study aims to study the proposals of two draft laws for direct elections of the Parliament of Southern Common Market in the face of attempted institutional improvement in the economic integration of the regional economic block. For this, we make a digression on direct elec- tions and the issue of the democratic deficit in Southern Common Market, including the pursuit of a balanced electoral system. After then we review two Brazilian legislative proposals for direct elections in Southern Common Market that enable outline the treatment of the issue in Brazil to implement an electoral legislative review of the Southern Common Market’s democracy that get access the region’s population to sub-regional governmental instances governmental.

  16. 75 FR 81287 - Mortgagee Review Board: Administrative Actions

    Science.gov (United States)

    2010-12-27

    ... closure of its home office location. 4. Gold Star Home Mortgage, LLC, St. Joseph, MO Action: On April 15... notify HUD of the closure of its home office and that it is no longer in business. 21. Action Mortgage... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND...

  17. 77 FR 64836 - Notice of Availability of Draft Environmental Impact Statement (DEIS), Draft Section 4(f...

    Science.gov (United States)

    2012-10-23

    ...), Draft Section 4(f) Evaluation, Notice of ANILCA Title XI evaluation, and Notice of Public Comment Period... and public hearing. ] SUMMARY: In accordance with the National Environmental Policy Act of 1969 (NEPA... prepared and is available for public review and comment. Included in the DEIS is a draft evaluation...

  18. Peer-review study of the draft handbook for human-reliability analysis with emphasis on nuclear-power-plant applications, NUREG/CR-1278

    Energy Technology Data Exchange (ETDEWEB)

    Brune, R. L.; Weinstein, M.; Fitzwater, M. E.

    1983-01-01

    This report describes a peer review of the draft Handbook for Human Reliability Analysis with Emphasis on Nuclear Power Plant Applications, NUREG/CR-1278. The purpose of the study was to determine to what extent peers agree with the human behavior models and estimates of human error probabilities (HEPs) contained in the Handbook. Twenty-nine human factors experts participated in the study. Twenty of the participants were Americans; nine were from other countries. The peers performed human reliability analyses of a variety of human performance scenarios describing operator activities in nuclear power plant settings. They also answered questionnaires pertaining to the contents and application of the Handbook. An analysis of peer solutions to the human reliability analysis problems and peer responses to the questionnaire was performed. Recommendations regarding the format and contents of the Handbook were developed from the study findings.

  19. 75 FR 43537 - Mortgagee Review Board: Administrative Actions

    Science.gov (United States)

    2010-07-26

    ... office and failed to notify HUD of the closure. 15. Home Mortgage, Inc., Burr Ridge, IL Action: On... notify HUD of a business change when it failed to notify HUD that it had closed its home office. 19... Uniform Residential Loan Application (URLA); failed to comply with HUD/FHA requirements for home office...

  20. How to Trick Your Opponent: A Review Article on Deceptive Actions in Interactive Sports

    OpenAIRE

    Iris Güldenpenning; Wilfried Kunde; Matthias Weigelt

    2017-01-01

    Performing deceptive actions is a wide-spread phenomenon in sports and it is of considerable practical relevance to know whether or not a fake or a disguised action decreases the opponents’ performance. Therefore, research on deceptive actions for various sport disciplines (e.g., cricket, rugby, martial arts, soccer, and basketball) has been conducted. This research is scattered, both across time and scientific disciplines. Here, we aim to systematically review the empirical work on deceptive...

  1. Resistance to aspirin: prevalence, mechanisms of action and association with thromboembolic events. A narrative review

    National Research Council Canada - National Science Library

    Cañivano Petreñas, L; García Yubero, C

    2010-01-01

    The purpose of this study is to review the prevalence of aspirin resistance in patients with a high risk of cardiovascular events, and secondly, to investigate its epidemiology and mechanism of action...

  2. 42 CFR 8.34 - Court review of final administrative action; exhaustion of administrative remedies.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Court review of final administrative action; exhaustion of administrative remedies. 8.34 Section 8.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF...; exhaustion of administrative remedies. Before any legal action is filed in court challenging the suspension...

  3. Action research studies in the intensive care setting: a systematic review.

    Science.gov (United States)

    Soh, K L; Davidson, P M; Leslie, G; Bin Abdul Rahman, Aisai

    2011-02-01

    To review published studies using action research in the intensive care unit (ICU) in order to provide an intervention framework to improve clinical outcomes. Systematic review. Searches of the electronic databases: Cumulative Index of Nursing and Allied Health Literature (CINAHL); Scopus, Medline, Embase, PsycINFO, and the World Wide Web were undertaken using MeSH key words including: 'action research'; 'health care research', 'health services evaluation'; 'intensive care unit'. Reference lists of retrieved articles was also undertaken to identify further articles. All studies were reviewed by two authors using a critical appraisal tool. The search strategy generated 195 articles. Only 21 studies projects were identified using action research in the ICU. The majority of studies were conducted in the United Kingdom. The participants in the action research studies ranged from 6 to 253. Predominately studies using action research involved nurses in collaboration with patients and family and other health care practitioners to address identified problems in the ICU. Based on this review it appears that action research is a promising methodological approach to address clinical practice improvement in the ICU. Studies retrieved focussed primarily on process and formative evaluation but not on clinical outcomes. There is a need to incorporate outcome assessment in action research in the ICU to increase the framework of action research to improve clinical outcomes. Copyright © 2010 Elsevier Ltd. All rights reserved.

  4. The Action Execution Process Implemented in Different Cognitive Architectures: A Review

    Science.gov (United States)

    Dong, Daqi; Franklin, Stan

    2014-12-01

    An agent achieves its goals by interacting with its environment, cyclically choosing and executing suitable actions. An action execution process is a reasonable and critical part of an entire cognitive architecture, because the process of generating executable motor commands is not only driven by low-level environmental information, but is also initiated and affected by the agent's high-level mental processes. This review focuses on cognitive models of action, or more specifically, of the action execution process, as implemented in a set of popular cognitive architectures. We examine the representations and procedures inside the action execution process, as well as the cooperation between action execution and other high-level cognitive modules. We finally conclude with some general observations regarding the nature of action execution.

  5. 76 FR 36133 - Draft Guidances for Industry and Food and Drug Administration Staff: Classification of Products...

    Science.gov (United States)

    2011-06-21

    ... HUMAN SERVICES Food and Drug Administration Draft Guidances for Industry and Food and Drug...(h) of the Federal Food, Drug, and Cosmetic Act AGENCY: Food and Drug Administration, HHS. ACTION... two related draft guidances for industry and FDA staff entitled ``Draft Guidance for Industry and FDA...

  6. 75 FR 47603 - Draft Guidance for Industry and Food and Drug Administration Staff; Recommendations for Premarket...

    Science.gov (United States)

    2010-08-06

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of the draft guidance entitled ``Draft Guidance for Industry and FDA...

  7. 77 FR 46986 - Revisions to Electric Quarterly Report Filing Process; Availability of Draft XML Schema

    Science.gov (United States)

    2012-08-07

    ...; Availability of Draft XML Schema AGENCY: Federal Energy Regulatory Commission. ACTION: Notice of Proposed...://www.ferc.gov ) a draft of the XML schema that is being developed for use in filing Electric Quarterly..., 2012). Please refer to the Supplementary Information Section below for details. DATES: The draft XML...

  8. 75 FR 1656 - Draft Safety Culture Policy Statement: Request for Public Comments; Extension of Comment Period

    Science.gov (United States)

    2010-01-12

    ... COMMISSION Draft Safety Culture Policy Statement: Request for Public Comments; Extension of Comment Period AGENCY: Nuclear Regulatory Commission (NRC). ACTION: Issuance of draft safety culture policy statement... a draft policy statement on safety culture to include the unique aspects of nuclear safety and...

  9. 76 FR 174 - NIJ Draft Metal Detector Standards for Public Safety

    Science.gov (United States)

    2011-01-03

    ... of Justice Programs NIJ Draft Metal Detector Standards for Public Safety AGENCY: National Institute of Justice. ACTION: Notice and request for comments on the Draft Metal Detector Standards for Public... the following draft standards for metal detectors: 1. Walk-through Metal Detector Standard for Public...

  10. Five-Year Review of CERCLA Response Actions at the Idaho National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    W. L. Jolley

    2007-02-01

    This report summarizes the documentation submitted in support of the five-year review or remedial actions implemented under the Comprehensive Environmental Response, Compensation, and Liability Act Sitewide at the Idaho National Laboratory. The report also summarizes documentation and inspections conducted at the no-further-action sites. This review covered actions conducted at 9 of the 10 waste area groups at the Idaho National Laboratory, i.e. Waste Area Groups 1, 2, 3, 4, 5, 6, 7, 9, and 10. Waste Area Group 8 was not subject to this review, because it does not fall under the jurisdiction of the U.S. Department of Energy Idaho Operations Office. The review included past site inspections and monitoring data collected in support of the remedial actions. The remedial actions have been completed at Waste Area Groups 2, 4, 5, 6, and 9. Remedial action reports have been completed for Waste Area Groups 2 and 4, and remedial action reports are expected to be completed during 2005 for Waste Area Groups 1, 5, and 9. Remediation is ongoing at Waste Area Groups 3, 7, and 10. Remedial investigations are yet to be completed for Operable Units 3-14, 7-13/14, and 10-08. The review showed that the remedies have been constructed in accordance with the requirements of the Records of Decision and are functioning as designed. Immediate threats have been addressed, and the remedies continue to be protective. Potential short-term threats are being addressed though institutional controls. Soil cover and cap remedies are being maintained properly and inspected in accordance with the appropriate requirements. Soil removal actions and equipment or system removals have successfully achieved remedial action objectives identified in the Records of Decision. The next Sitewide five-year review is scheduled for completion by 2011.

  11. Action research in public schools: is it research? Should it be reviewed?

    Science.gov (United States)

    Sigler, Ellen

    2009-06-01

    TEACHERS CONDUCT IN-CLASS ACTION research to solve classroom problems. Cases of K-12 classroom action research were examined to determine which of them require ethics review. A variety of action research projects were collected and transformed into fictitious examples that could be systematically examined to answer these questions pertinent to whether ethics review is required. The resulting analysis suggested that much classroom action research is a local curriculum development activity, which solves important problems but does not require ethics review for various reasons. If it is human research, as defined in the U.S. Common Rule, and is funded by an agency covered by the Common Rule, or if it is not funded but is human research conducted within an institution that has agreed to review all human research, ethics review is legally required unless the intervention is normal educational practice. However, since some action research may trigger other legal requirements, such as the U.S. Family Educational Rights and Privacy Act of 1979 (FERPA), it may be desirable to have some form of school-based review, but typically not human subjects ethics review.

  12. 78 FR 55694 - Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, Wyoming

    Science.gov (United States)

    2013-09-11

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, Wyoming AGENCY... review of the draft research report titled, ``Investigation of Ground Water Contamination near Pavillion...

  13. 77 FR 19012 - Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, WY

    Science.gov (United States)

    2012-03-29

    ...] Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, WY AGENCY... titled, ``Investigation of Ground Water Contamination near Pavillion, Wyoming.'' The draft research... Agency policy or views. Eastern Research Group, Inc., an EPA contractor for external peer review, will...

  14. 78 FR 48504 - Proposed Revisions to Maintenance Rule Standard Review Plan

    Science.gov (United States)

    2013-08-08

    ... COMMISSION Proposed Revisions to Maintenance Rule Standard Review Plan AGENCY: Nuclear Regulatory Commission. ACTION: Standard review plan-draft section revision; request for comment. SUMMARY: The U.S. Nuclear... soliciting public comment on NUREG-0800, ``Standard Review Plan for the Review of Safety Analysis Reports for...

  15. Current Practice and Theoretical Foundations of the After Action Review

    Science.gov (United States)

    2011-06-01

    creation of organizational knowledge ( Nonaka & Takeuchi , 1995). Doctrine collects the extracted expressed and analyzed learning of individuals within the...1995) Leadership Performance Appraisals Hoyt, Halverson, Murphy & Watson (2003) Knowledge Management Knowledge, Goals Nonaka & Takeuchi (1995...review of the experimental research. Organizational Behavior and Human Performance, 23, 309-338. Nonaka , I., & Takeuchi , H. (1995). The knowledge

  16. Literature Review on the Use of Action Research in Higher Education

    Science.gov (United States)

    Gibbs, Paul; Cartney, Patricia; Wilkinson, Kate; Parkinson, John; Cunningham, Sheila; James-Reynolds, Carl; Zoubir, Tarek; Brown, Venetia; Barter, Phil; Sumner, Pauline; MacDonald, Angus; Dayananda, Asanka; Pitt, Alexandra

    2017-01-01

    This literature review considers the use of action research in higher education. The review specifically looks at two areas of higher education activity. The first concerns academic teaching practice and includes a discussion of research and pedagogy practice, and staff development. The second considers student engagement. In both of these core…

  17. ICLUS Tools and Datasets (Version 1.2) and User's Manual: Arcgis Tools and Datasets for Modeling US Housing Density (External Review Draft)

    Science.gov (United States)

    This draft Geographic Information System (GIS) tool can be used to generate scenarios of housing-density changes and calculate impervious surface cover for the conterminous United States. A draft User’s Guide accompanies the tool. This product distributes the population project...

  18. How to Trick Your Opponent: A Review Article on Deceptive Actions in Interactive Sports

    Directory of Open Access Journals (Sweden)

    Iris Güldenpenning

    2017-05-01

    Full Text Available Performing deceptive actions is a wide-spread phenomenon in sports and it is of considerable practical relevance to know whether or not a fake or a disguised action decreases the opponents’ performance. Therefore, research on deceptive actions for various sport disciplines (e.g., cricket, rugby, martial arts, soccer, and basketball has been conducted. This research is scattered, both across time and scientific disciplines. Here, we aim to systematically review the empirical work on deceptive actions in interactive sports and want to give an overview about several issues investigated in the last decades. Three main topics of the detected literature were discussed here: (1 the role of expertise for the recognition of deceptive actions, (2 the cognitive mechanisms underlying the processing of deceptive actions, and (3 the pros and cons of in situ research designs. None of these themes seems to be settled and therefore, they should be considered in future research agendas.

  19. How to Trick Your Opponent: A Review Article on Deceptive Actions in Interactive Sports.

    Science.gov (United States)

    Güldenpenning, Iris; Kunde, Wilfried; Weigelt, Matthias

    2017-01-01

    Performing deceptive actions is a wide-spread phenomenon in sports and it is of considerable practical relevance to know whether or not a fake or a disguised action decreases the opponents' performance. Therefore, research on deceptive actions for various sport disciplines (e.g., cricket, rugby, martial arts, soccer, and basketball) has been conducted. This research is scattered, both across time and scientific disciplines. Here, we aim to systematically review the empirical work on deceptive actions in interactive sports and want to give an overview about several issues investigated in the last decades. Three main topics of the detected literature were discussed here: (1) the role of expertise for the recognition of deceptive actions, (2) the cognitive mechanisms underlying the processing of deceptive actions, and (3) the pros and cons of in situ research designs. None of these themes seems to be settled and therefore, they should be considered in future research agendas.

  20. Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 124: Storage Tanks, Nevada Test Site, Nevada (Draft), Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Alfred Wickline

    2007-04-01

    This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses closure for Corrective Action Unit (CAU) 124, Areas 8, 15, and 16 Storage Tanks, identified in the Federal Facility Agreement and Consent Order. Corrective Action Unit 124 consists of five Corrective Action Sites (CASs) located in Areas 8, 15, and 16 of the Nevada Test Site as follows: • 08-02-01, Underground Storage Tank • 15-02-01, Irrigation Piping • 16-02-03, Underground Storage Tank • 16-02-04, Fuel Oil Piping • 16-99-04, Fuel Line (Buried) and UST This plan provides the methodology of field activities necessary to gather information to close each CAS. There is sufficient information and process knowledge from historical documentation and investigations of similar sites regarding the expected nature and extent of potential contaminants to recommend closure of CAU 124 using the SAFER process.

  1. Bioinformatics Training: A Review of Challenges, Actions and Support Requirements

    DEFF Research Database (Denmark)

    Schneider, M.V.; Watson, J.; Attwood, T.

    2010-01-01

    As bioinformatics becomes increasingly central to research in the molecular life sciences, the need to train non-bioinformaticians to make the most of bioinformatics resources is growing. Here, we review the key challenges and pitfalls to providing effective training for users of bioinformatics...... services, and discuss successful training strategies shared by a diverse set of bioinformatics trainers. We also identify steps that trainers in bioinformatics could take together to advance the state of the art in current training practices. The ideas presented in this article derive from the first...

  2. A desk review of health services system of different countries as a guide to action in Indian context

    Directory of Open Access Journals (Sweden)

    Vikas Bajpai

    2016-01-01

    Full Text Available The health policy in the country seems to be in a limbo. The fate of the Draft National Health Policy, 2015 continues to be uncertain as it continues exist in draft stage as yet. Resultantly, there remains much confusion as to the path that the country shall adopt to achieve ‘Universal Health Care’ (UHC. Viewing this as an opportunity to inform policy making by drawing on the experience of countries that have already made noticeable progress towards achieving UHC, the author has conducted a desk review of the health services system of four such developing countries – Sri Lanka, Thailand, Brazil and Cuba, along with their socioeconomic coordinates and compared it with that of India. Appropriate lessons for India have been drawn from this comparison.

  3. 75 FR 71702 - Science Advisory Board Staff Office; Request for Nominations of Experts for Review of EPA's Draft...

    Science.gov (United States)

    2010-11-24

    ... Monitoring AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The EPA Science Advisory... concerning the EPA Science Advisory Board can be found at the EPA SAB Web site at http://www.epa.gov/sab...) for the Panel as a whole, diversity of expertise and viewpoints. The SAB Staff Office's evaluation of...

  4. 78 FR 51719 - Draft Toxicological Review of Benzo[a]pyrene: In Support of the Summary Information in the...

    Science.gov (United States)

    2013-08-21

    ... IRIS toxicity values with exposure information to characterize public health risks of chemical... Integrated Risk Information System (IRIS) AGENCY: Environmental Protection Agency (EPA). ] ACTION: Notice of... Support of Summary Information on the Integrated Risk Information System (IRIS)'' (EPA/635/R-13/138) and...

  5. 76 FR 23755 - Release of Draft Risk and Exposure Assessments and Final Integrated Review Plan for the National...

    Science.gov (United States)

    2011-04-28

    ... risk and exposure analyses that EPA is preparing to conduct in support of the reviews of ozone NAAQS... specific questions or organize comments by referencing a Code of Federal Regulations (CFR) part or section... the NAAQS for ozone. Key components of this review include a quantitative population exposure analysis...

  6. Draft Scientific Report Connectivity of Streams and Wetlands to Downstream Waters: A Review and Synthesis of the Scientific Evidence

    Science.gov (United States)

    Synthesizes peer-reviewed scientific literature on the biological, chemical, and hydrologic connectivity of waters and the effects that small streams, wetlands, and open waters have on larger downstream waters such as rivers, lakes, estuaries, and oceans.

  7. EU-stress test: Swiss national action plan. Follow-up of peer review 2012 year-end status report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-12-15

    The European Union (EU) stress test is part of the review process which Switzerland initiated immediately after the reactor accident in Japan. As a direct consequence of the accident, the Swiss Federal Nuclear Safety Inspectorate (ENSI) issued three formal orders in which the operators of the Swiss nuclear power plants (NPPs) were required to implement immediate measures and to conduct additional reassessments. The immediate measures comprised the establishment of an external emergency storage facility for the Swiss NPPs, including the necessary plant-specific connections, and back-fittings to provide external injection into the spent fuel pools. The additional reassessments focused on the design of the Swiss NPPs against earthquakes, external flooding and a combination thereof. Investigations on the coolant supply for the safety systems and the spent fuel pool cooling were also requested. ENSI carried out an analysis of the events at Fukushima providing detailed descriptions of the causes, consequences and radiological impacts of the accident. The reports analyse the contributory human and organisational factors, and specify lessons that can be derived from this information. ENSI instructed the Swiss operators to take part in the EU stress test. There was to be particular examination of the robustness of the NPPs in case of impacts beyond the design basis due to earthquakes, external flooding and extreme weather conditions, with consequential loss of power supply and heat sink, and the need for severe accident management actions. ENSI requested further clarification on plant specific issues and produced the National Report which was delivered to the EU Commission. A Country Peer Review Draft Report was drawn up for each country, including a list of issues (open points) for further follow-up by the review team. Eight new open points were identified to further improve the safety of the Swiss NPPs. These open points together with the issues identified in the analysis

  8. 78 FR 70571 - Notice of Availability of the Oregon Greater Sage-Grouse Draft Land Use Plan Amendments and Draft...

    Science.gov (United States)

    2013-11-26

    ... directed the formulation of alternatives and framed the scope of analysis in the Draft LUP Amendments/Draft... proposed designation of an ACEC. Pursuant to 43 CFR 1610.7-2(b), this notice announces a concurrent public... review, we cannot guarantee that we will be able to do so. Authority: 40 CFR 1506.6, 40 CFR 1506.10, 43...

  9. Radioactive waste isolation in salt: Peer review of the Office of Nuclear Waste Isolation's draft report on an issues hierarchy and data needs for site characterization

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, W.; Fenster, D.F.; Ditmars, J.D.; Paddock, R.A.; Rote, D.M.; Hambley, D.F.; Seitz, M.G.; Hull, A.B.

    1986-12-01

    At the request of the Salt Repository Project (SRPO), Argonne National Laboratory conducted an independent peer review of a report by the Battelle Office of Nuclear Waste Isolation entitled ''Salt Repository Project Issues Hierarchy and Data Needs for Site Characterization (Draft).'' This report provided a logical structure for evaluating the outstanding questions (issues) related to selection and licensing of a site as a high-level waste repository. It also provided a first estimate of the information and data necessary to answer or resolve those questions. As such, this report is the first step in developing a strategy for site characterization. Microfiche copies of ''Draft Issues Hierarchy, Resolution Strategy, and Information Needs for Site Characterization and Environmental/Socioeconomic Evaluation - July, 1986'' and ''Issues Hierarchy and Data Needs for Site Characterization - February, 1985'' are included in the back pocket of this report.

  10. Identity and collective action via computer-mediated communication: A review and agenda for future research

    NARCIS (Netherlands)

    Priante, Anna; Ehrenhard, Michel Léon; van den Broek, Tijs Adriaan; Need, Ariana

    2017-01-01

    Since the start of large-scale waves of mobilisation in 2011, the importance of identity in the study of collective action via computer-mediated communication (CMC) has been a source of contention. Hence, our research sets out to systematically review and synthesise empirical findings on identity

  11. 77 FR 68790 - Program Comment Issued for Streamlining Section 106 Review for Actions Affecting Post-1945...

    Science.gov (United States)

    2012-11-16

    ... Review for Actions Affecting Post-1945 Concrete and Steel Bridges AGENCY: Advisory Council on Historic... post-1945 concrete and steel bridges. SUMMARY: The Advisory Council on Historic Preservation (ACHP.... Four respondents to the Federal Register notice objected to the premise that post-1945 concrete and...

  12. Development of a Relative Potency Factor (Rpf) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of polycyclic aromatic hydrocarbon (PAH) mixtures that when finalized will appear on the Integrated Risk Information System (IRIS) database. ...

  13. Assessment of the Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking Water Resources (External Review Draft)

    Science.gov (United States)

    This assessment provides a review and synthesis of available scientific literature and data to assess the potential for hydraulic fracturing for oil and gas to impact the quality or quantity of drinking water resources, and identifies factors affecting the frequency or severity o...

  14. 76 FR 11506 - Fisheries and Habitat Conservation and Migratory Birds Programs; Draft Land-Based Wind Energy...

    Science.gov (United States)

    2011-03-02

    ...; Draft Land-Based Wind Energy Guidelines; Correction AGENCY: Fish and Wildlife Service, Interior. ACTION... comment of draft Land-Based Wind Energy Guidelines (Guidelines). We are issuing a correction to that... Land-Based Wind Energy Guidelines (Guidelines). These draft Guidelines do not supersede the Service's...

  15. 77 FR 64349 - Notice of Availability of the Draft West Eugene Wetlands Resource Management Plan/Environmental...

    Science.gov (United States)

    2012-10-19

    ... Bureau of Land Management Notice of Availability of the Draft West Eugene Wetlands Resource Management Plan/Environmental Impact Statement, Oregon AGENCY: Bureau of Land Management, Interior. ACTION: Notice... (BLM) has prepared a Draft Resource Management Plan (RMP) and Draft Environmental Impact Statement (EIS...

  16. Hypertrophic Effects of Concentric vs. Eccentric Muscle Actions: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Schoenfeld, Brad J; Ogborn, Dan I; Vigotsky, Andrew D; Franchi, Martino V; Krieger, James W

    2017-09-01

    Schoenfeld, BJ, Ogborn, DI, Vigotsky, AD, Franchi, MV, and Krieger, JW. Hypertrophic effects of concentric vs. eccentric muscle actions: A systematic review and meta-analysis. J Strength Cond Res 31(9): 2599-2608, 2017-Controversy exists as to whether different dynamic muscle actions produce divergent hypertrophic responses. The purpose of this paper was to conduct a systematic review and meta-analysis of randomized controlled trials comparing the hypertrophic effects of concentric vs. eccentric training in healthy adults after regimented resistance training (RT). Studies were deemed eligible for inclusion if they met the following criteria: (a) were an experimental trial published in an English-language refereed journal; (b) directly compared concentric and eccentric actions without the use of external implements (i.e., blood pressure cuffs) and all other RT variables equivalent; (c) measured morphologic changes using biopsy, imaging (magnetic resonance imaging, computerized tomography, or ultrasound), bioelectrical impedance, and/or densitometry; (d) had a minimum duration of 6 weeks; and (e) used human participants without musculoskeletal injury or any health condition that could directly, or through the medications associated with the management of said condition, be expected to impact the hypertrophic response to resistance exercise. A systematic literature search determined that 15 studies met inclusion criteria. Results showed that eccentric muscle actions resulted in a greater effect size (ES) compared with concentric actions, but results did not reach statistical significance (ES difference = 0.25 ± 0.13; 95% confidence interval: -0.03 to 0.52; p = 0.076). The mean percent change in muscle growth across studies favored eccentric compared with concentric actions (10.0% vs. 6.8, respectively). The findings indicate the importance of including eccentric and concentric actions in a hypertrophy-oriented RT program, as both have shown to be effective in

  17. Youth bullying: a review of the science and call to action.

    Science.gov (United States)

    Vessey, Judith A; DiFazio, Rachel L; Strout, Tania D

    2013-01-01

    Recognized as a critical public health problem, youth bullying is reportedly experienced by approximately 20% of today's youths. In the last decade, attention to bullying has increased and the scientific knowledge base relevant for practitioners who treat youths, research their issues, and create policy has expanded. The purpose of this review is to highlight key developments related to the health effects of bullying, interventions aimed at curbing bullying behaviors, the measurement of bullying, and nursing's disciplinary response to this phenomenon. A call to action for nurses involved in caring for youths across settings and roles is offered and strategic actions for nursing professionals are provided. Published by Mosby, Inc.

  18. Draft Test Guideline: Aquatic Food Chain Transfer

    Science.gov (United States)

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  19. MINERAL TRIOXIDE AGGREGATE - A REVIEWING OF ITS COMPOSITION, MECHANISM OF ACTION AND CLINICAL INDICATIOS

    Directory of Open Access Journals (Sweden)

    Denis Damião Costa

    2012-07-01

    Full Text Available The mineral trioxide aggregate is a useful material in dentistry, easy to manipulation and with appreciated physics, chemistry and biological characteristics. Its main action is at the dentinogenesis, cementogenesis and osteogenesis induction. Has advantages over other materials, because it promotes marginal sealing near to the ideal, has biocompatibility, does not induce harmful effect to the organism, it is unprovided of mutagenic potential and cytotoxicity. Because of its properties, the aggregate can be applied successfully in many clinical situations, like root perforations and resorption, pulpotomy, direct pulp capping and paraendodontic surgery. Many studies confirm its applicability and indicate a promising action of this material in dentistry, although is still premature consider it an ideal material. The aim of this study is reviewing the literature regarding the composition of this material, its mechanism of action and their clinical applications.

  20. Executive Summary, Hydraulic Fracturing Study - Draft Assessment 2015

    Science.gov (United States)

    In this Executive Summary of the HF Draft report, EPA highlights the reviews of scientific literature to assess the potential for hydraulic fracturing for oil and gas to change the quality or quantity of drinking water resources.

  1. Choose Health Action Teens: A Review of a Teens as Teachers Nutritional Education Training Curriculum

    Directory of Open Access Journals (Sweden)

    Jeffrey M. Flesch

    2016-12-01

    Full Text Available This review draws from published research related to the best practices for the utilization of teens as teachers to examine Choose Health Action Teens (CHAT, a teen’s as teachers (TAT training curriculum.  Research shows that there are various components necessary to build a high quality TAT program.  Most of these components fall under four areas in which training is necessary for teens and adults: Teaching strategies, youth/child development, subject matter to be taught, and youth-adult partnerships.  These four areas provide a framework to review the Choose Health Action Teens (CHAT (Crosiar & Wolfe, 2013 teens as teachers training program curriculum.

  2. A Review of Training Methods and Instructional Techniques: Implications for Behavioral Skills Training in U.S. Astronauts (DRAFT)

    Science.gov (United States)

    Hysong, Sylvia J.; Galarza, Laura; Holland, Albert W.

    2007-01-01

    Long-duration space missions (LDM) place unique physical, environmental and psychological demands on crewmembers that directly affect their ability to live and work in space. A growing body of research on crews working for extended periods in isolated, confined environments reveals the existence of psychological and performance problems in varying degrees of magnitude. The research has also demonstrated that although the environment plays a cathartic role, many of these problems are due to interpersonal frictions (Wood, Lugg, Hysong, & Harm, 1999), and affect each individual differently. Consequently, crewmembers often turn to maladaptive behaviors as coping mechanisms, resulting in decreased productivity and psychological discomfort. From this body of research, critical skills have been identified that can help a crewmember better navigate the psychological challenges of long duration space flight. Although most people lack several of these skills, most of them can be learned; thus, a training program can be designed to teach crewmembers effective leadership, teamwork, and self-care strategies that will help minimize the emergence of maladaptive behaviors. Thus, it is the purpose of this report is twofold: 1) To review the training literature to help determine the optimal instructional methods to use in delivering psychological skill training to the U.S. Astronaut Expedition Corps, and 2) To detail the structure and content of the proposed Astronaut Expedition Corps Psychological Training Program.

  3. The action of corticosteroids on orthodontic tooth movement: a literature review

    OpenAIRE

    Luegya Amorim Henriques Knop; Ricardo Lima Shintcovsk; Luciana Borges Retamoso; Ana Maria Trindade Grégio; Orlando Tanaka

    2012-01-01

    INTRODUCTION: Tooth movement is initially characterized by an acute sterile inflammation, followed by sequential multiple reactions in the periodontal ligament in response to biomechanical forces. Pharmacological agents such as corticosteroids may affect the course of orthodontic movement. Scientific studies show antagonistic actions of these drugs on bone resorption during tooth movement. OBJECTIVE: To review the literature about the effect of corticosteroids on orthodontic tooth movement. C...

  4. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

    OpenAIRE

    Pasupuleti, Visweswara Rao; Sammugam, Lakhsmi; Ramesh, Nagesvari; Gan, Siew Hua

    2017-01-01

    Background. There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. Scope and Approach. In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. Key Findings and Conclusions. An overview of honey, p...

  5. Nanomaterial Case Study: A Comparison of Multiwalled Carbon Nanotube and Decabromodiphenyl Ether Flame-Retardant Coatings Applied to Upholstery Textiles (External Review Draft)

    Science.gov (United States)

    The draft document is intended to be used as part of a process to identify what is known and, more importantly, what is not yet known that could be of value in assessing the broad implications of specific nanomaterials. Like previous case studies (see History/ Chronology below), ...

  6. Integrated Science Assessment (ISA) for Oxides of Nitrogen, Oxides of Sulfur and Particulate Matter - Ecological Criteria (First External Review Draft, Mar 2017)

    Science.gov (United States)

    This draft ISA document represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA’s decision on retaining or revising the current secondary standards for NO2, SO2, PM 2.5 and PM 10 since the prior re...

  7. Computer Assisted Drafting (CNC) Drawings. Drafting Module 6. Instructor's Guide.

    Science.gov (United States)

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. This unit contains information on computer-assisted drafting drawings. The guide contains a cross-reference table of instructional materials and 20 worksheets.…

  8. 77 FR 40048 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Actions

    Science.gov (United States)

    2012-07-06

    ... is, the pesticide can perform its intended function without unreasonable adverse effects on human... adverse human health impacts or environmental effects from exposure to the pesticide(s) discussed in this... without unreasonable adverse effects on human health or the environment. A pesticide's registration review...

  9. 75 FR 80496 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    Science.gov (United States)

    2010-12-22

    ... review dockets for bitrex, calcium carbonate, diethyl-2- (4-methylbenzyloxy)ethylamine (PT807-HCl... it will not be opening a docket for bitrex, calcium carbonate, diethyl-2-(4-methylbenzyloxy... consider your comment. Electronic files should avoid the use of special characters, any form of encryption...

  10. Mechanisms of action of fungi and bacteria used as biofertilizers in agricultural soils : a systematic review

    Directory of Open Access Journals (Sweden)

    Sara Paulina Restrepo-Correa

    2017-05-01

    Full Text Available Phosphorus, nitrogen, iron and potassium are some compounds necessary for plant growth and development; chemical fertilizers used to increase concentration significantly affect the environment and soil ecosystems. According to the scientific literature, microorganisms with biofertilizer potential have demonstrated various mechanisms of action to solubilize these compounds and thus meet the requirements of plants. This systematic review collects scientific information that describes the mechanisms of action of microbial fertilizers in agricultural soils, published between 2004 and 2014, in three different databases; ScienceDirect, SpringerLink and Scopus,using the search path (biofertilizer AND (bacteria OR fungi AND (effect OR action OR mechanism. After using different inclusion and exclusion criteria, the search displayed a total of 63 original articles, including six unindexed documents. As a result of the systematic review, it indicates that the production of various organic acids allows soil acidification, facilitating absorption of elements. It was also observed that solubilization of P is the most described mechanism, by obtaining a solubilizing of 726.5 mg/L of P due to P. pseudoalcaligenes

  11. A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin

    Directory of Open Access Journals (Sweden)

    Gaurang P Mavani

    2015-03-01

    Full Text Available The pressor and antidiuretic actions of arginine vasopressin (AVP have been well documented. This review focuses on the less widely appreciated actions of AVP which also have important physiologic functions and when better understood may provide important insights into common disease states. These actions include effects on pain perception and bone structure as well as important relationships to the varied components of metabolic syndrome. These include effects on blood glucose, lipid levels, and blood pressure. AVP may also play a role in the progression of chronic kidney disease and effect physiologic changes relating to aging, abnormal social behavior and cognitive function. Important cellular responses including cell proliferation, inflammation and control of infection and their relationship to AVP are described. Finally, the effects of AVP on hemostasis and the hypothalamic-pituitary-adrenal access are noted. The goal of this summary of the various actions of AVP is to direct attention to the potential benefits of research in these underemphasized areas of importance.

  12. 78 FR 44117 - Notice of a Public Comment Period on the Draft IRIS Carcinogenicity Assessment for Ethylene Oxide

    Science.gov (United States)

    2013-07-23

    ... policy or views. DATES: The 45-day public comment period on the draft Evaluation of the Inhalation... announcing a 45-day public comment period on the draft IRIS assessment titled, ``Evaluation of the Inhalation... public has been provided an opportunity to comment on a previous external review draft of the Evaluation...

  13. 77 FR 29617 - Notice of Availability of the Draft Environmental Impact Statement for the Tarmac King Road...

    Science.gov (United States)

    2012-05-18

    ... Availability of the Draft Environmental Impact Statement for the Tarmac King Road Limestone Mine Proposed in... Environmental Impact Statement (Draft EIS) has been completed and is available for review and comment. DATES: In accordance with the National Environmental Policy Act (NEPA), we have filed the Draft EIS with the U.S...

  14. 75 FR 45653 - Notice of Re-Opening of Comment Period for the Draft Imperial Sand Dunes Recreation Area...

    Science.gov (United States)

    2010-08-03

    ... Bureau of Land Management Notice of Re-Opening of Comment Period for the Draft Imperial Sand Dunes Recreation Area Management Plan and Draft Environmental Impact Statement, California AGENCY: Bureau of Land... Cottage Way, Sacramento, California 95825. Interested persons may also review the Draft Resource...

  15. Motor imagery during action observation: A brief review of evidence, theory and future research opportunities

    Directory of Open Access Journals (Sweden)

    Daniel Lloyd Eaves

    2016-11-01

    Full Text Available Motor imagery (MI and action observation (AO have traditionally been viewed as two separate techniques, which can both be used alongside physical practice to enhance motor learning and rehabilitation. Their independent use has been shown to be effective, and there is clear evidence that the two processes can elicit similar activity in the motor system. Building on these well-established findings, research has now turned to investigate the effects of their combined use. In this article, we first review the available neurophysiological and behavioral evidence for the effects of combined action observation and motor imagery (‘AO+MI’ on motor processes. We next describe a conceptual framework for their combined use, and then discuss several areas for future research into AO+MI processes. In this review, we advocate a more integrated approach to AO+MI techniques than has previously been adopted by movement scientists and practitioners alike. We hope this early review of an emergent body of research, along with a related set of research questions, can inspire new work in this area. We are optimistic that future research will further confirm if, how, and when this combined approach to AO+MI can be more effective in motor learning and rehabilitation settings, relative to the more traditional application of AO or MI independently.

  16. Using the Knowledge to Action Framework in practice: a citation analysis and systematic review.

    Science.gov (United States)

    Field, Becky; Booth, Andrew; Ilott, Irene; Gerrish, Kate

    2014-11-23

    Conceptual frameworks are recommended as a way of applying theory to enhance implementation efforts. The Knowledge to Action (KTA) Framework was developed in Canada by Graham and colleagues in the 2000s, following a review of 31 planned action theories. The framework has two components: Knowledge Creation and an Action Cycle, each of which comprises multiple phases. This review sought to answer two questions: 'Is the KTA Framework used in practice? And if so, how?' This study is a citation analysis and systematic review. The index citation for the original paper was identified on three databases-Web of Science, Scopus and Google Scholar-with the facility for citation searching. Limitations of English language and year of publication 2006-June 2013 were set. A taxonomy categorising the continuum of usage was developed. Only studies applying the framework to implementation projects were included. Data were extracted and mapped against each phase of the framework for studies where it was integral to the implementation project. The citation search yielded 1,787 records. A total of 1,057 titles and abstracts were screened. One hundred and forty-six studies described usage to varying degrees, ranging from referenced to integrated. In ten studies, the KTA Framework was integral to the design, delivery and evaluation of the implementation activities. All ten described using the Action Cycle and seven referred to Knowledge Creation. The KTA Framework was enacted in different health care and academic settings with projects targeted at patients, the public, and nursing and allied health professionals. The KTA Framework is being used in practice with varying degrees of completeness. It is frequently cited, with usage ranging from simple attribution via a reference, through informing planning, to making an intellectual contribution. When the framework was integral to knowledge translation, it guided action in idiosyncratic ways and there was theory fidelity. Prevailing wisdom

  17. 78 FR 11654 - Draft Guidance for Industry and Food and Drug Administration Staff; Providing Information About...

    Science.gov (United States)

    2013-02-19

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Food, Drug, and Cosmetic Act; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... entitled ``Draft Guidance for Industry and Food and Drug Administration Staff: Providing Information About...

  18. 75 FR 57081 - Revised Draft Safety Culture Policy Statement: Request for Comments

    Science.gov (United States)

    2010-09-17

    ..., participation in a Special Joint Session on Safety Culture at the Health Physics Society Annual Meeting, and... COMMISSION Revised Draft Safety Culture Policy Statement: Request for Comments AGENCY: Nuclear Regulatory Commission (NRC). ACTION: Issuance of revised Draft Safety Culture Policy Statement and notice of opportunity...

  19. 77 FR 67379 - Draft Guidance for Industry and Food and Drug Administration Staff; Highly Multiplexed...

    Science.gov (United States)

    2012-11-09

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Devices; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and... pathogen nucleic acids extracted from a single appropriate human specimen or culture. This draft guidance...

  20. 77 FR 8262 - Draft Guidance on Investigational New Drug Applications for Positron Emission Tomography Drugs...

    Science.gov (United States)

    2012-02-14

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance on Investigational New Drug Applications for Positron Emission Tomography Drugs; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a draft guidance...

  1. 77 FR 16990 - Notification of Submission to the Secretary of Agriculture of Two Draft Regulatory Documents...

    Science.gov (United States)

    2012-03-23

    ... of Agriculture of Two Draft Regulatory Documents Under FIFRA AGENCY: Environmental Protection Agency (EPA). ] ACTION: Notification of submission to the Secretary of Agriculture. SUMMARY: This document... Certificate Final Rule''. The draft regulatory documents are not available to the public until after they have...

  2. 75 FR 4380 - Draft Test Guidelines; Notice of Availability and Request for Comments

    Science.gov (United States)

    2010-01-27

    ... AGENCY Draft Test Guidelines; Notice of Availability and Request for Comments AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: EPA is announcing the availability of four draft test... (703) 305-5805. Electronic access to the OPPTS Test Guidelines: To access the OPPTS harmonized test...

  3. 75 FR 57963 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Science.gov (United States)

    2010-09-23

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Helicobacter pylori; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food... pylori.'' This draft guidance document provides industry and agency staff with updated recommendations...

  4. 76 FR 72436 - Draft Environmental Impact Statement for Protecting and Restoring Native Ecosystems by Managing...

    Science.gov (United States)

    2011-11-23

    ...; 2310-0057-422] Draft Environmental Impact Statement for Protecting and Restoring Native Ecosystems by..., Interior. ACTION: Notice of Availability for Draft Environmental Impact Statement for Protecting and Restoring Native Ecosystems by Managing Non-Native Ungulates. SUMMARY: The National Park Service (NPS...

  5. 78 FR 37795 - Draft NOAA Procedures for Government to Government Consultation With Federally Recognized Indian...

    Science.gov (United States)

    2013-06-24

    ... National Oceanic and Atmospheric Administration RIN 0648-XC726 Draft NOAA Procedures for Government to... Administration (NOAA), Commerce. ACTION: Notice; request for comments. SUMMARY: NOAA announces the availability of and request for comments on the Draft NOAA Procedures for Government-to-Government Consultation...

  6. 78 FR 69705 - Notice of Availability of the Draft Resource Management Plan Amendment and Environmental...

    Science.gov (United States)

    2013-11-20

    ... Bureau of Land Management Notice of Availability of the Draft Resource Management Plan Amendment and Environmental Assessment for the San Luis Resource Area, CO AGENCY: Bureau of Land Management, Interior. ACTION... (BLM) San Luis Valley Field Office prepared a Draft Resource Management Plan Amendment (RMPA) with an...

  7. A review and comparative analysis of European priority indices for noise action plans.

    Science.gov (United States)

    D'Alessandro, Francesco; Schiavoni, Samuele

    2015-06-15

    The European Union has provided in recent years (and is going to update) several tools to harmonise noise mapping methodologies through directives and guidelines. Unfortunately the same efforts have not been put in the harmonisation of approaches for Noise Action Plans, the effective instruments to manage noise impacts. As a consequence, each European Member State at national or even at local level defined its own methodology, usually considerably different one from the others. Nevertheless, the most common approach to deal with noise impact at a policy, economic and strategy level is the use of priority indices focused to highlight areas or buildings where mitigation actions are more advisable or urgent. The aim of the present research is to provide a review of the most used European priority indices and also to test some of them in a study area. The comparative analysis demonstrates that the method chosen for the prioritisation deeply affects the ranking of the areas where noise measures need to be realized. Some methods tend to give high priority to noise sensitive locations, others to high populated buildings, and others to the areas where noise levels are high. The study proves how much common approaches are needed also for Noise Action Plans to reach a coherent noise policy within European boundaries. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. A review on alcohol: from the central action mechanism to chemical dependency

    Directory of Open Access Journals (Sweden)

    João Victor Vezali Costardi

    2015-08-01

    Full Text Available SummaryIntroduction:alcohol is a psychotropic depressant of the central nervous system (CNS that promotes simultaneous changes in several neuronal pathways, exerting a profound neurological impact that leads to various behavioral and biological alterations.Objectives:to describe the effects of alcohol on the CNS, identifying the signaling pathways that are modified and the biological effects resulting from its consumption.Methods:a literature review was conducted and articles published in different languages over the last 15 years were retrieved.Results:the studies reviewed describe the direct effect of alcohol on several neurotransmitter receptors (gamma-aminobutyric acid [GABA], glutamate, endocannabinoids AEA and 2-AG, among others, the indirect effect of alcohol on the limbic and opioid systems, and the effect on calcium and potassium channels and on proteins regulated by GABA in the hippocampus.Discussion and conclusion:the multiple actions of alcohol on the CNS result in a general effect of psychomotor depression, difficulties in information storage and logical reasoning and motor incoordination, in addition to stimulating the reward system, a fact that may explain the development of addiction. Knowledge on the neuronal signaling pathways that are altered by alcohol allows the identification of effectors which could reduce its central action, thus, offering new therapeutic perspectives for the rehabilitation of alcohol addicts.

  9. [Resistance to aspirin: prevalence, mechanisms of action and association with thromboembolic events. A narrative review].

    Science.gov (United States)

    Cañivano Petreñas, L; García Yubero, C

    2010-01-01

    The purpose of this study is to review the prevalence of aspirin resistance in patients with a high risk of cardiovascular events, and secondly, to investigate its epidemiology and mechanism of action, and the clinical consequences it can provoke. A search was run on PubMed, EMBASE and Reviews Database for English or Spanish articles on aspirin resistance published up to November 2008. Additional studies were obtained by searching the reference lists in the selected articles for articles relevant to our secondary objectives. Aspirin resistance is described as affecting 0 to 57% of the population, and is related to a decreased protective effect against strokes and cardiovascular events. Many modifiable and unmodifiable factors can affect the efficacy of antiplatelet drugs. Possible strategies for overcoming this decreased antiaggregant effect include increasing the aspirin dosage or dual therapy with another antiplatelet agent. Lack of response to aspirin decreases its protective effects. However, lack of a standard definition for aspirin resistance, the absence of diagnostic reference methods to identify resistant patients, and the different mechanisms of action involved in platelet aggregation call the clinical importance of this fact into question. Additional well-designed studies are needed to detect patients with real resistance in order to have more effective prevention of cardiovascular morbidity and mortality. Copyright (c) 2009 SEFH. Published by Elsevier Espana. All rights reserved.

  10. Public Review Draft: A Method for Assessing Carbon Stocks, Carbon Sequestration, and Greenhouse-Gas Fluxes in Ecosystems of the United States Under Present Conditions and Future Scenarios

    Science.gov (United States)

    Bergamaschi, Brian A.; Bernknopf, Richard; Clow, David; Dye, Dennis; Faulkner, Stephen; Forney, William; Gleason, Robert; Hawbaker, Todd; Liu, Jinxun; Liu, Shu-Guang; Prisley, Stephen; Reed, Bradley; Reeves, Matthew; Rollins, Matthew; Sleeter, Benjamin; Sohl, Terry; Stackpoole, Sarah; Stehman, Stephen; Striegl, Robert G.; Wein, Anne; Zhu, Zhi-Liang; Zhu, Zhi-Liang

    2010-01-01

    The Energy Independence and Security Act of 2007 (EISA), Section 712, authorizes the U.S. Department of the Interior to develop a methodology and conduct an assessment of the Nation's ecosystems focusing on carbon stocks, carbon sequestration, and emissions of three greenhouse gases (GHGs): carbon dioxide, methane, and nitrous oxide. The major requirements include (1) an assessment of all ecosystems (terrestrial systems, such as forests, croplands, wetlands, shrub and grasslands; and aquatic ecosystems, such as rivers, lakes, and estuaries), (2) an estimation of annual potential capacities of ecosystems to increase carbon sequestration and reduce net GHG emissions in the context of mitigation strategies (including management and restoration activities), and (3) an evaluation of the effects of controlling processes, such as climate change, land use and land cover, and wildlfires. The purpose of this draft methodology for public review is to propose a technical plan to conduct the assessment. Within the methodology, the concepts of ecosystems, carbon pools, and GHG fluxes used for the assessment follow conventional definitions in use by major national and international assessment or inventory efforts. In order to estimate current ecosystem carbon stocks and GHG fluxes and to understand the potential capacity and effects of mitigation strategies, the method will use two time periods for the assessment: 2001 through 2010, which establishes a current ecosystem GHG baseline and will be used to validate the models; and 2011 through 2050, which will be used to assess future potential conditions based on a set of projected scenarios. The scenario framework is constructed using storylines of the Intergovernmental Panel on Climate Change (IPCC) Special Report Emission Scenarios (SRES), along with initial reference land-use and land-cover (LULC) and land-management scenarios. An additional three LULC and land-management mitigation scenarios will be constructed for each

  11. A review of accelerated response actions available to the environmental restoration program: Selected case histories and associated issues. [CONTAINS GLOSSARY

    Energy Technology Data Exchange (ETDEWEB)

    Smyth, J D; Quinn, R D [Pacific Northwest Lab., Richland, WA (USA); Gianti, S J [CH2M Hill, Reston, VA (USA)

    1991-05-01

    Accelerated actions were developed by the Environmental Protection Agency (EPA) within the regulatory framework for initiating early cleanup action or accelerating ongoing cleanup action to abate, mitigate, or reduce risk to human health or the environment at a contaminated waste site. The purposes of this report are to review the regulatory frameworks available to initiate accelerated actions at sites on the National Priorities List (NPL) and to provide case histories of sites where accelerated actions have been implemented. The findings of this report are applicable to non-NPL waste sites also. Accelerated actions are of interest to the Department of Energy (DOE) for two primary reasons: they are methods available to demonstrate progress in environmental restoration at DOE waste sites, and a subset of accelerated actions, termed interim remedial actions, may be required in place of final actions to avoid violating National Environmental Policy Act (NEPA) guidelines during the development of DOE Office of Environmental Restoration and Waste Management's (DOE- EM's) Programmatic Environmental Impact Statement (PEIS). To provide the case histories, interviews with staff and reviews of compliance documents were conducted for sites in EPA Regions 3, 4, and 7. 12 refs., 1 fig.

  12. The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research

    Directory of Open Access Journals (Sweden)

    Hui Wang

    2014-01-01

    Full Text Available Rhizoma Coptidis (Huang Lian in Chinese pinyin is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions.

  13. 77 FR 61426 - Rose Atoll National Wildlife Refuge, American Samoa; Draft Comprehensive Conservation Plan and...

    Science.gov (United States)

    2012-10-09

    ...We, the U.S. Fish and Wildlife Service (Service), announce the availability of our Draft Comprehensive Conservation Plan and Environmental Assessment (Draft CCP/EA) for the Rose Atoll National Wildlife Refuge (NWR/refuge) for public review and comment. In the Draft CCP/EA, we present two alternatives for managing this refuge for the next 15 years, as well as related compatibility determinations for the preferred alternative.

  14. Clarification to 1998 Agreement Regarding the National Remedy Review Board Review Criteria for Department of Energy Non-Time Critical Removal Actions

    Science.gov (United States)

    The purpose of this memorandum is to provide additional clarification on the applicability of the October 5, 1998, joint Environmental Protection Agency (EPA) and the Department of Energy (DOE) agreement on DOE decommissioning projects titled Review of Department of Energy Non-Time Critical Removal Actions by the National Remedy Review Board.

  15. 75 FR 69649 - Notice of Availability for the Draft Programmatic Environmental Assessment for the Development...

    Science.gov (United States)

    2010-11-15

    ... action is to reduce dependency on fossil fuels and increase energy security and efficiency through... CONUS facilities. Environmental resources addressed in the Draft PEA include land use; noise; geological resources; water resources; biological resources; cultural resources; visual resources; socioeconomics; air...

  16. 76 FR 32367 - Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by...

    Science.gov (United States)

    2011-06-06

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by Clinical Investigators; Correction AGENCY: Food and Drug Administration, HHS. ACTION: Notice; correction. SUMMARY: The Food and Drug Administration (FDA) is correcting a...

  17. 78 FR 38092 - Notice of Availability of a Draft Environmental Assessment

    Science.gov (United States)

    2013-06-25

    ..., Manager, Infrastructure Engineering Center, Federal Aviation Administration, 2300 East Devon Avenue, Des... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Availability of a Draft Environmental Assessment AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Availability of a...

  18. 76 FR 43689 - Draft Guidance for Industry and Food and Drug Administration Staff; Mobile Medical Applications...

    Science.gov (United States)

    2011-07-21

    ... Staff; Mobile Medical Applications; Availability AGENCY: Food and Drug Administration, HHS. ACTION... guidance entitled ``Mobile Medical Applications.'' FDA is issuing this draft guidance to inform... select software applications intended for use on mobile platforms (mobile applications or ``mobile apps...

  19. A Comprehensive Review on Handcrafted and Learning-Based Action Representation Approaches for Human Activity Recognition

    Directory of Open Access Journals (Sweden)

    Allah Bux Sargano

    2017-01-01

    Full Text Available Human activity recognition (HAR is an important research area in the fields of human perception and computer vision due to its wide range of applications. These applications include: intelligent video surveillance, ambient assisted living, human computer interaction, human-robot interaction, entertainment, and intelligent driving. Recently, with the emergence and successful deployment of deep learning techniques for image classification, researchers have migrated from traditional handcrafting to deep learning techniques for HAR. However, handcrafted representation-based approaches are still widely used due to some bottlenecks such as computational complexity of deep learning techniques for activity recognition. However, approaches based on handcrafted representation are not able to handle complex scenarios due to their limitations and incapability; therefore, resorting to deep learning-based techniques is a natural option. This review paper presents a comprehensive survey of both handcrafted and learning-based action representations, offering comparison, analysis, and discussions on these approaches. In addition to this, the well-known public datasets available for experimentations and important applications of HAR are also presented to provide further insight into the field. This is the first review paper of its kind which presents all these aspects of HAR in a single review article with comprehensive coverage of each part. Finally, the paper is concluded with important discussions and research directions in the domain of HAR.

  20. Adaptation of the US Army's After-Action Review for simulation debriefing in healthcare.

    Science.gov (United States)

    Sawyer, Taylor Lee; Deering, Shad

    2013-12-01

    Postsimulation debriefing is a critical component of effective learning in simulation-based health care education. Numerous formats in which to conduct the debriefing have been proposed. In this report, we describe the adaptation the US Army's After-Action Review (AAR) debriefing format for postsimulation debriefing in health care. The Army's AAR format is based on sound educational theory and has been used with great success in the US Army and civilian organizations for decades. Debriefing using the health care simulation AAR process requires planning, preparation, and follow-up. Conducting a postsimulation debriefing using the health care simulation AAR debriefing format includes 7 sequential steps as follows: (1) define the rules of the debriefing, (2) explain the learning objectives of the simulation, (3) benchmark performance, (4) review what was supposed to happen during the simulation, (5) identify what actually happened, (6) examine why events occurred the way they did, and (7) formalize learning by reviewing with the group what went well, what did not go well and what they would do differently if faced with a similar situation in real life. We feel that the use of the health care simulation AAR debriefing format provides a structured and supported method to conduct an effective postsimulation debriefing, with a focus on the learning objectives and reliance on preidentified performance standards.

  1. A review of the mechanism of action of lasers and photodynamic therapy for onychomycosis.

    Science.gov (United States)

    Bhatta, Anil Kumar; Keyal, Uma; Wang, Xiuli; Gellén, Emese

    2017-02-01

    Onychomycosis is one of the most common diseases in the field of dermatology. It refers to the fungal infection of the nail plate or nail bed with high incidence in the general population. The available treatment options for onychomycosis have limited use due to side effects, drug interactions, and contraindications, which necessitates the application of an alternative treatment for onychomycosis. In the recent years, lasers and photodynamic therapy (PDT) have been recognized as alternative treatment options. Most of the previous studies have found them to be safe and effective treatment modalities in this indication; however, the results varied greatly and the in vitro and in vivo outcomes are contradictory. In the present review, studies related to the mechanism of action of lasers and PDT for the treatment of onychomycosis will be discussed, with a focus on to find explanation to the contradictory results.

  2. Herbal Remedies for Coccidiosis Control: A Review of Plants, Compounds, and Anticoccidial Actions

    Directory of Open Access Journals (Sweden)

    Thangarasu Muthamilselvan

    2016-01-01

    Full Text Available Coccidiosis is the bane of the poultry industry causing considerable economic loss. Eimeria species are known as protozoan parasites to cause morbidity and death in poultry. In addition to anticoccidial chemicals and vaccines, natural products are emerging as an alternative and complementary way to control avian coccidiosis. In this review, we update recent advances in the use of anticoccidial phytoextracts and phytocompounds, which cover 32 plants and 40 phytocompounds, following a database search in PubMed, Web of Science, and Google Scholar. Four plant products commercially available for coccidiosis are included and discussed. We also highlight the chemical and biological properties of the plants and compounds as related to coccidiosis control. Emphasis is placed on the modes of action of the anticoccidial plants and compounds such as interference with the life cycle of Eimeria, regulation of host immunity to Eimeria, growth regulation of gut bacteria, and/or multiple mechanisms. Biological actions, mechanisms, and prophylactic/therapeutic potential of the compounds and extracts of plant origin in coccidiosis are summarized and discussed.

  3. Herbal Remedies for Coccidiosis Control: A Review of Plants, Compounds, and Anticoccidial Actions

    Science.gov (United States)

    Muthamilselvan, Thangarasu; Wu, Yueh-Chen

    2016-01-01

    Coccidiosis is the bane of the poultry industry causing considerable economic loss. Eimeria species are known as protozoan parasites to cause morbidity and death in poultry. In addition to anticoccidial chemicals and vaccines, natural products are emerging as an alternative and complementary way to control avian coccidiosis. In this review, we update recent advances in the use of anticoccidial phytoextracts and phytocompounds, which cover 32 plants and 40 phytocompounds, following a database search in PubMed, Web of Science, and Google Scholar. Four plant products commercially available for coccidiosis are included and discussed. We also highlight the chemical and biological properties of the plants and compounds as related to coccidiosis control. Emphasis is placed on the modes of action of the anticoccidial plants and compounds such as interference with the life cycle of Eimeria, regulation of host immunity to Eimeria, growth regulation of gut bacteria, and/or multiple mechanisms. Biological actions, mechanisms, and prophylactic/therapeutic potential of the compounds and extracts of plant origin in coccidiosis are summarized and discussed. PMID:27429634

  4. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits.

    Science.gov (United States)

    Pasupuleti, Visweswara Rao; Sammugam, Lakhsmi; Ramesh, Nagesvari; Gan, Siew Hua

    2017-01-01

    There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions.

  5. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

    Directory of Open Access Journals (Sweden)

    Visweswara Rao Pasupuleti

    2017-01-01

    Full Text Available Background. There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. Scope and Approach. In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. Key Findings and Conclusions. An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions.

  6. Viral inactivation in hemotherapy: systematic review on inactivators with action on nucleic acids

    Directory of Open Access Journals (Sweden)

    Patricia Marial Sobral

    2012-01-01

    Full Text Available The aim of this study was to conduct a systematic review on the photoinactivators used in hemotherapy, with action on viral genomes. The SciELO, Science Direct, PubMed and Lilacs databases were searched for articles. The inclusion criterion was that these should be articles on inactivators with action on genetic material that had been published between 2000 and 2010. The key words used in identifying such articles were "hemovigilance", "viral inactivation", "photodynamics", "chemoprevention" and "transfusion safety". Twenty-four articles on viral photoinactivation were found with the main photoinactivators covered being: methylene blue, amotosalen HCl, S-303 frangible anchor linker effector (FRALE, riboflavin and inactin. The results showed that methylene blue has currently been studied least, because it diminishes coagulation factors and fibrinogen. Riboflavin has been studied most because it is a photoinactivator of endogenous origin and has few collateral effects. Amotosalen HCl is effective for platelets and is also used on plasma, but may cause changes both to plasma and to platelets, although these are not significant for hemostasis. S-303 FRALE may lead to neoantigens in erythrocytes and is less indicated for red-cell treatment; in such cases, PEN 110 is recommended. Thus, none of the methods for pathogen reduction is effective for all classes of agents and for all blood components, but despite the high cost, these photoinactivators may diminish the risk of blood-transmitted diseases.

  7. Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review

    Directory of Open Access Journals (Sweden)

    F. Bafort

    2014-01-01

    Full Text Available Lactoperoxidase is a member of the family of the mammalian heme peroxidases which have a broad spectrum of activity. Their best known effect is their antimicrobial activity that arouses much interest in in vivo and in vitro applications. In this context, the proper use of lactoperoxidase needs a good understanding of its mode of action, of the factors that favor or limit its activity, and of the features and properties of the active molecules. The first part of this review describes briefly the classification of mammalian peroxidases and their role in the human immune system and in host cell damage. The second part summarizes present knowledge on the mode of action of lactoperoxidase, with special focus on the characteristics to be taken into account for in vitro or in vivo antimicrobial use. The last part looks upon the characteristics of the active molecule produced by lactoperoxidase in the presence of thiocyanate and/or iodide with implication(s on its antimicrobial activity.

  8. A review of ideomotor approaches to perception, cognition, action, and language: advancing a cultural recycling hypothesis.

    Science.gov (United States)

    Badets, Arnaud; Koch, Iring; Philipp, Andrea M

    2016-01-01

    The term "cultural recycling" derives from the neuronal recycling hypothesis, which suggests that representations of cultural inventions like written words, Arabic numbers, or tools can occupy brain areas dedicated to other functions. In the present selective review article, we propose a recycling hypothesis for the ideomotor mechanism. The ideomotor approach assumes that motor actions are controlled by the anticipation of the expected perceptual consequences that they aim to generate in the environment. Arguably, such action-perception mechanisms contribute to motor behaviour for human and non-human animals since millions of years. However, recent empirical studies suggest that the ideomotor mechanism can also contribute to word processing, number representation, and arithmetic. For instance, it has been shown that the anticipatory simulation of abstract semantics, like the numerical quantitative value of three items can prime processing of the associated Arabic number "3". Arabic numbers, words, or tools represent cultural inventions, so that, from a theoretical perspective, we suggest an ideomotor recycling hypothesis for the interaction with such artefacts. In this view, the ideomotor mechanism spreads its influence to other functions beyond motor control, and is recycled to flexibly adapt different human behaviours towards dealing with more abstract concepts.

  9. 77 FR 5247 - Draft Integrated Science Assessment for Lead

    Science.gov (United States)

    2012-02-02

    ... policy, viewpoint, or determination. EPA will consider any public comments submitted in response to this... the submission of recent scientific information on specified topics. Soon after, a science policy... AGENCY Draft Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency (EPA). ACTION...

  10. 76 FR 26284 - Draft Integrated Science Assessment for Lead (Pb)

    Science.gov (United States)

    2011-05-06

    ... workshop was held on May 10-11, 2010 (75 FR 20843) to discuss policy- relevant science to inform EPA's... AGENCY Draft Integrated Science Assessment for Lead (Pb) AGENCY: Environmental Protection Agency (EPA). ] ACTION: Notice of public comment period. SUMMARY: The U.S. Environmental Protection Agency (EPA) is...

  11. 76 FR 50231 - Mobile Medical Applications Draft Guidance; Public Workshop

    Science.gov (United States)

    2011-08-12

    ... HUMAN SERVICES Food and Drug Administration Mobile Medical Applications Draft Guidance; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public workshop; request for comments. SUMMARY: The Food and Drug Administration (FDA) is announcing a public workshop entitled: ``Mobile Medical...

  12. Impact of safety-related regulatory action on clinical practice: a systematic review.

    Science.gov (United States)

    Piening, Sigrid; Haaijer-Ruskamp, Flora M; de Vries, Jonie T N; van der Elst, Menno E; de Graeff, Pieter A; Straus, Sabine M J M; Mol, Peter G M

    2012-05-01

    After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of the effects of these drug safety warnings on clinical practice to resolve the debate about their effectiveness. The aim of this systematic review is to provide an overview of studies that assessed the impact of safety warnings. A systematic search was performed for articles assessing the impact of Direct Healthcare Professional Communications or 'Dear Doctor' letters, Black Box Warnings and Public Health Advisories on clinical behaviour published between January 1996 and January 2010. The following variables were extracted: publication year, country, name of the drug, safety issue, specific safety warning (Direct Healthcare Professional Communication/Black Box Warning/Public Health Advisory), effect (intended/unintended) of the safety warning, outcome measure and study design. Papers were checked for several quality aspects. Study data were summarized using descriptive analyses. A total of 50 articles were identified. Two articles assessed two different drugs and were therefore counted twice (n = 52). Thirty-three articles described the impact of safety warnings issued for three drugs and drug groups, i.e. third-generation oral contraceptives, cisapride and selective serotonin reuptake inhibitors. The remaining 19 articles described a broad variety of 14 drugs and drug groups. Twenty-five studies applied an interrupted time series design, 23 a controlled or uncontrolled before/after design, and four articles applied both. None of the articles could rule out the influence of confounding factors. The intended effects were reported in 18 (72%) of the 25 before/after analyses, whereas only 11 (41%) of the 27 interrupted time series analyses reported an impact. Only two (8%) of the

  13. 75 FR 6696 - Draft Recovery Plan for Tidal Marsh Ecosystems of Northern and Central California

    Science.gov (United States)

    2010-02-10

    ... Fish and Wildlife Service Draft Recovery Plan for Tidal Marsh Ecosystems of Northern and Central... draft recovery plan for Tidal Marsh Ecosystems of Northern and Central California for public review and... Salt Marsh Harvest Mouse Recovery Plan. The plan also addresses several federally endangered plant...

  14. Re: “Comments on draft rules for granting Foreign Tax Credit”

    NARCIS (Netherlands)

    Sanghavi, Dhruv

    2016-01-01

    This letter to the Indian Ministry of Finance critically reviews the proposed rules for the grant of credit in India for taxes paid in a foreign country (Draft Rules). It points out what is perhaps the most egregious drawback in the Draft Rules - they do not consider the erosive impact foreign

  15. 77 FR 62234 - Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, WY

    Science.gov (United States)

    2012-10-12

    ...-0895] Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, WY AGENCY... titled, ``Investigation of Ground Water Contamination near Pavillion, Wyoming.'' The draft research... Agency policy or views. Eastern Research Group, Inc., an EPA contractor for external peer review, will...

  16. 76 FR 51034 - Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy...

    Science.gov (United States)

    2011-08-17

    ... Chemotherapy During Pregnancy; Request for Comments; Announcement of a Panel Meeting To Peer Review Draft... of the Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy During Pregnancy... of Cancer Chemotherapy During Pregnancy, which has been prepared by the NTP Office of Health...

  17. Performance Reporting - The IASB's Proposed Formats of Financial Statements in the Exposure Draft of IAS1

    DEFF Research Database (Denmark)

    Thinggaard, Frank; Wagenhofer, Alfred; Evans, Lisa

    2006-01-01

    This paper is a response to the Exposure Draft of proposed amendments to IAS 1 Presentation of Financial Statements published by the IASB in March 2006. The objective is to bring to the standard setter’s attention research that is relevant to the issues raised in the exposure draft. We review...

  18. Pipe drafting and design

    CERN Document Server

    Parisher, Roy A; Parisher

    2000-01-01

    Pipe designers and drafters provide thousands of piping drawings used in the layout of industrial and other facilities. The layouts must comply with safety codes, government standards, client specifications, budget, and start-up date. Pipe Drafting and Design, Second Edition provides step-by-step instructions to walk pipe designers and drafters and students in Engineering Design Graphics and Engineering Technology through the creation of piping arrangement and isometric drawings using symbols for fittings, flanges, valves, and mechanical equipment. The book is appropriate primarily for pipe

  19. Pipe drafting and design

    CERN Document Server

    Parisher, Roy A

    2011-01-01

    Pipe Drafting and Design, Third Edition provides step-by-step instructions to walk pipe designers, drafters, and students through the creation of piping arrangement and isometric drawings. It includes instructions for the proper drawing of symbols for fittings, flanges, valves, and mechanical equipment. More than 350 illustrations and photographs provide examples and visual instructions. A unique feature is the systematic arrangement of drawings that begins with the layout of the structural foundations of a facility and continues through to the development of a 3-D model. Advanced chapters

  20. How to Trick Your Opponent: A Review Article on Deceptive Actions in Interactive Sports

    National Research Council Canada - National Science Library

    Iris Güldenpenning; Wilfried Kunde; Matthias Weigelt

    2017-01-01

    Performing deceptive actions is a wide-spread phenomenon in sports and it is of considerable practical relevance to know whether or not a fake or a disguised action decreases the opponents’ performance...

  1. Action Research, Assessment, and Institutional Review Boards (IRB): Conflicting Demands or Productive Tension for the Academic Librarian?

    Science.gov (United States)

    Farrell, Robert

    2014-01-01

    This article puts forward an "assessment/action research/publication" cycle that integrates aspects of the assessment, research, and Institutional Review Board (IRB) processes to provide academic librarians with a systematic approach for balancing competing workplace demands and give library managers a roadmap for creating a…

  2. 45 CFR 60.10 - Reporting negative actions or findings taken by peer review organizations or private...

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Reporting negative actions or findings taken by peer review organizations or private accreditation entities. 60.10 Section 60.10 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NATIONAL PRACTITIONER DATA BANK FOR ADVERSE...

  3. The role of action potential alternans in the initiation of atrial fibrillation in humans: a review and future directions

    Science.gov (United States)

    Franz, Michael R.; Jamal, Sameer M.; Narayan, Sanjiv M.

    2012-01-01

    This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation. PMID:23104916

  4. Review of Indigenous Health Curriculum in Nutrition and Dietetics at One Australian University: An Action Research Study

    Science.gov (United States)

    Wilson, Annabelle M.; Mehta, Kaye; Miller, Jacqueline; Yaxley, Alison; Thomas, Jolene; Jackson, Kathryn; Wray, Amanda; Miller, Michelle D.

    2015-01-01

    This article describes a review undertaken in 2012-2013 by Nutrition and Dietetics, Flinders University, to assess the Indigenous health curriculum of the Bachelor of Nutrition and Dietetics (BND) and Masters of Nutrition and Dietetics (MND). An action research framework was used to guide and inform inquiry. This involved four stages, each of…

  5. 22 CFR 1423.10 - Determination not to issue complaint; review of action by the Regional Director.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Determination not to issue complaint; review of action by the Regional Director. 1423.10 Section 1423.10 Foreign Relations FOREIGN SERVICE LABOR...; AND THE FOREIGN SERVICE IMPASSE DISPUTES PANEL FOREIGN SERVICE LABOR RELATIONS BOARD AND GENERAL...

  6. 76 FR 51038 - Draft Guidance for Industry: Cell Selection Devices for Point of Care Production of Minimally...

    Science.gov (United States)

    2011-08-17

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Cell Selection Devices for... Draft Guidance AGENCY: Food and Drug Administration, HHS. ACTION: Notice; withdrawal. SUMMARY: The Food... Guidance for Industry: Cell Selection Devices for Point of Care Production of Minimally Manipulated...

  7. 78 FR 48713 - Notice of Availability of the Draft Environmental Impact Statement for the Ochoa Mine Project in...

    Science.gov (United States)

    2013-08-09

    ... Management (BLM) has prepared a Draft Environmental Impact Statement (EIS) for the Ochoa Mine Project... Bureau of Land Management Notice of Availability of the Draft Environmental Impact Statement for the Ochoa Mine Project in Lea County, New Mexico AGENCY: Bureau of Land Management, Interior. ACTION: Notice...

  8. 78 FR 26398 - Public Comment and Public Meeting on Draft Revisions to the Foreign Missions and International...

    Science.gov (United States)

    2013-05-06

    ... COMMISSION Public Comment and Public Meeting on Draft Revisions to the Foreign Missions and International... Capital Planning Commission. ACTION: Notice of public comment period and public meeting. SUMMARY: The... National Capital Region, intends to release for public comment draft revisions to the Foreign Missions and...

  9. 76 FR 9027 - Draft Guidance for Industry and Food and Drug Administration Staff on Best Practices for...

    Science.gov (United States)

    2011-02-16

    ... Electronic Healthcare Data Sets; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration...

  10. Categorizing health-related cues to action: using Yelp reviews of restaurants in Hawaii

    Science.gov (United States)

    Ariyasriwatana, W.; Buente, W.; Oshiro, M.; Streveler, D.

    2014-10-01

    Yelp, a social media site, undeniably has an influence on consumers' food choice in spite of its ability to reflect consumers' real voice being criticized. Since unhealthy food choices contribute to health problems, such as obesity and malnourishment, we attempted to examine these problems by better understanding consumers through health-related cues to action-a construct from the Health Belief Model (HBM)- on Yelp Honolulu's restaurant reviews. Our research revealed 13 main categories: Ingredient, Type of food, Taste, Lifestyle, Cooking, Option, Price, Portion, Well-being, Nutrition, Hygiene, Emotional attachment and indulgence, and Feeling. We argue that these categories may ultimately lead consumers to make healthier food choices. In search of the most appealing way to communicate with the target group, underlying concepts that derived from these categories can be tested. Marketers in food industry (or public health policy-makers) can craft their strategies for healthy food brands/products (or healthy eating scheme) based on the concept test research. Moreover, Yelp can apply these insights in the development of their algorithm and filter system in order to help consumers find healthy food if they wish to do so. Restaurants can also improve their strategy, menu, and communication execution to meet the growing demands of health conscious consumers.

  11. Are we prepared to develop palliative actions in a ward? A literature review

    Directory of Open Access Journals (Sweden)

    Lara Cardoso

    2017-05-01

    Full Text Available Introduction: The World Health Organization (2015 presents as barriers to improving access to palliative care the lack of training and awareness of health professionals. Objectives: Identify the preparation of nurses who provide care, in the acute hospital setting, to develop palliative actions. Methods: Integrative literature review, through the electronic research in the B-ON platform, using the expression: (nursing AND (palliative care AND (acute hospital setting NOT (child* OR infant* OR adolescent*, obtaining six articles of primary studies. Results: Obtained studies are representative of a total of 2220 nurses. The articles showed that nurses from acute hospitals, despite being able to care for patients with palliative care needs, felt that training in this area would be important in order to better understand the needs of these patients. Conclusion: Nurses consider that they have competencies to provide care related to palliative care in acute care, although recognizing that they should be provided with more formation.

  12. Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

    Directory of Open Access Journals (Sweden)

    Marcio A. R. Araujo

    2011-09-01

    Full Text Available Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity of propolis of different origins and/or its isolated components, focusing on the mechanisms of action underlying this activity and also addressing some aspects of immunomodulatory effects. The search was performed of the following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate and ISI Web of Knowledgement. The anti-inflammatory activity was associated with propolis or compounds such as polyphenols (flavonoids, phenolic acids and their esters, terpenoids, steroids and amino acids. CAPE is the most studied compounds. The main mechanisms underlying the anti-inflammatory activity of propolis included the inhibition of cyclooxygenase and consequent inhibition of prostaglandin biosynthesis, free radical scavenging, inhibition of nitric oxide synthesis, reduction in the concentration of inflammatory cytokines and immunosuppressive activity. Propolis was found to exert an anti-inflammatory activity in vivo and in vitro models of acute and chronic inflammation and others studies, indicating its promising potential as anti-inflammatory agent of natural origin and as a source of chemical compounds for the development of new drugs.

  13. PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting

    Directory of Open Access Journals (Sweden)

    Karolina N. Dziadkowiec

    2017-02-01

    Full Text Available Poly(ADP-ribose polymerases have shown true promise in early clinical studies due to reported activity in BRCA-associated cancers. PARP inhibitors may represent a potentially important new class of chemotherapeutic agents directed at targeting cancers with defective DNA-damage repair. In order to widen the prospective patient population that would benefit from PARP inhibitors, predictive biomarkers based on a clear understanding of the mechanism of action are required. In addition, a more sophisticated understanding of the toxicity profile is required if PARP inhibitors are to be employed in the curative, rather than the palliative, setting. PARP inhibitors have successfully moved into clinical practice in the past few years, with approval granted from the Food and Drug Administration (FDA and European Medicines Agency (EMA within the past two years. The United States FDA approval of olaparib applies to fourth-line treatment in germline BRCA-mutant ovarian cancer, and European EMA approval of olaparib for maintenance therapy in both germline and somatic BRCA-mutant platinum-sensitive ovarian cancer. This review covers the current understanding of PARP, its inhibition, and the basis of the excitement surrounding these new agents. It also evaluates future approaches and directions required to achieve full understanding of the intricate interplay of these agents at the cellular level.

  14. Draft 1992 Resource Program : Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-01-01

    The 1992 Resource Program will propose actions to meet future loads placed on the Bonneville Power Administration (BPA). It will also discuss and attempt to resolve resource-related policy issues. The Resource Program assesses resource availability and costs, and analyzes resource requirements and alternative ways of meeting those requirements through both conservation and generation resources. These general resource conclusions are then translated to actions for both conservation and generation. The Resource Program recommends budgets for the Office of Energy Resources for Fiscal Years (FY) 1994 and 1995. BPA`s Resource Program bears directly on an important BPA responsibility: the obligation under the Northwest Power Act{sup 3} to meet the power requirements of public and private utility and direct service industrial (DSI) customers according to their contractual agreements. BPA`s Draft 1992 Resource Program is contained in four documents: (1) 1992 Resource Program Summary; (2) Technical Report; (3) Technical Assumptions Appendix; and, (4) Conservation Implementation Plan. This volume is the Draft 1992 Resource Program Technical Report, a comprehensive document that provides supporting data and analyses for Resource Program recommendations.

  15. Draft 1992 Resource Program : Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-01-01

    The 1992 Resource Program will propose actions to meet future loads placed on the Bonneville Power Administration (BPA). It will also discuss and attempt to resolve resource-related policy issues. The Resource Program assesses resource availability and costs, and analyzes resource requirements and alternative ways of meeting those requirements through both conservation and generation resources. These general resource conclusions are then translated to actions for both conservation and generation. The Resource Program recommends budgets for the Office of Energy Resources for Fiscal Years (FY) 1994 and 1995. BPA's Resource Program bears directly on an important BPA responsibility: the obligation under the Northwest Power Act{sup 3} to meet the power requirements of public and private utility and direct service industrial (DSI) customers according to their contractual agreements. BPA's Draft 1992 Resource Program is contained in four documents: (1) 1992 Resource Program Summary; (2) Technical Report; (3) Technical Assumptions Appendix; and, (4) Conservation Implementation Plan. This volume is the Draft 1992 Resource Program Technical Report, a comprehensive document that provides supporting data and analyses for Resource Program recommendations.

  16. Replacement Nuclear Research Reactor. Supplement to Draft Environmental Impact Statement. Volume 3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    The Draft Environmental Impact Statement for a replacement research reactor at Lucas Heights, was available for public examination and comment for some three months during 1998. A Supplement to the Draft Environmental Impact Statement (Draft EIS) has been completed and was lodged with Environment Australia on 18 January 1999. The Supplement is an important step in the overall environmental assessment process. It reviews submissions received and provides the proponent`s response to issues raised in the public review period. General issues extracted from submissions and addressed in the Supplement include concern over liability issues, Chernobyl type accidents, the ozone layer and health issues. Further studies, relating to issues raised in the public submission process, were undertaken for the Supplementary EIS. These studies confirm, in ANSTO`s view, the findings of the Draft EIS and hence the findings of the Final EIS are unchanged from the Draft EIS

  17. An inexpensive underwater mine countermeasures simulator with real-time 3D after action review

    Directory of Open Access Journals (Sweden)

    Robert Stone

    2016-10-01

    Full Text Available This paper presents the results of a concept capability demonstration pilot study, the aim of which was to investigate how inexpensive gaming software and hardware technologies could be exploited in the development and evaluation of a simulator prototype for training Royal Navy mine clearance divers, specifically focusing on the detection and accurate reporting of the location and condition of underwater ordnance. The simulator was constructed using the Blender open source 3D modelling toolkit and game engine, and featured not only an interactive 3D editor for underwater scenario generation by instructors, but also a real-time, 3D After Action Review (AAR system for formative assessment and feedback. The simulated scenarios and AAR architecture were based on early human factors observations and briefings conducted at the UK's Defence Diving School (DDS, an organisation that provides basic military diving training for all Royal Navy and Army (Royal Engineers divers. An experimental pilot study was undertaken to determine whether or not basic navigational and mine detection components of diver performance could be improved as a result of exposing participants to the AAR system, delivered between simulated diving scenarios. The results suggest that the provision of AAR was accompanied by significant performance improvements in the positive identification of simulated underwater ordnance (in contrast to non-ordnance objects and on participants' description of their location, their immediate in-water or seabed context and their structural condition. Only marginal improvements were found with participants' navigational performance in terms of their deviation accuracies from a pre-programmed expert search path. Overall, this project contributes to the growing corpus of evidence supporting the development of simulators that demonstrate the value of exploiting open source gaming software and the significance of adopting established games design

  18. The action of corticosteroids on orthodontic tooth movement: a literature review

    Directory of Open Access Journals (Sweden)

    Luegya Amorim Henriques Knop

    2012-12-01

    Full Text Available INTRODUCTION: Tooth movement is initially characterized by an acute sterile inflammation, followed by sequential multiple reactions in the periodontal ligament in response to biomechanical forces. Pharmacological agents such as corticosteroids may affect the course of orthodontic movement. Scientific studies show antagonistic actions of these drugs on bone resorption during tooth movement. OBJECTIVE: To review the literature about the effect of corticosteroids on orthodontic tooth movement. CONCLUSION: Patients should be questioned regarding the use of these drugs in the orthodontic practice and for those who use them, the orthodontic treatment should be differentiated, with longer intervals between visits and periodic X-rays due to the delay in bone formation observed in some scientific studies.INTRODUÇÃO: a movimentação dentária é caracterizada, inicialmente, por uma inflamação aguda estéril, seguida por reações múltiplas sequenciais no ligamento periodontal em resposta às forças biomecânicas. Agentes farmacológicos, como os corticosteroides, podem alterar o curso da movimentação ortodôntica. Os estudos científicos demonstram ações antagonistas dessas drogas sobre a reabsorção óssea durante a movimentação dentária. OBJETIVO: realizar revisão de literatura sobre a ação dos corticosteroides no movimento dentário ortodôntico. CONCLUSÃO: os pacientes devem ser questionados quanto ao uso dessas drogas na clínica ortodôntica e, para aqueles que fazem uso, o tratamento ortodôntico deve ser diferenciado, com intervalos maiores entre as consultas e solicitação periódica de radiografias devido ao atraso na neoformação óssea observado em alguns estudos científicos.

  19. Peer Review Evaluation Process of Marie Curie Actions under EU's Seventh Framework Programme for Research.

    Science.gov (United States)

    Pina, David G; Hren, Darko; Marušić, Ana

    2015-01-01

    We analysed the peer review of grant proposals under Marie Curie Actions, a major EU research funding instrument, which involves two steps: an independent assessment (Individual Evaluation Report, IER) performed remotely by 3 raters, and a consensus opinion reached during a meeting by the same raters (Consensus Report, CR). For 24,897 proposals evaluated from 2007 to 2013, the association between average IER and CR scores was very high across different panels, grant calls and years. Median average deviation (AD) index, used as a measure of inter-rater agreement, was 5.4 points on a 0-100 scale (interquartile range 3.4-8.3), overall, demonstrating a good general agreement among raters. For proposals where one rater disagreed with the other two raters (n=1424; 5.7%), or where all 3 raters disagreed (n=2075; 8.3%), the average IER and CR scores were still highly associated. Disagreement was more frequent for proposals from Economics/Social Sciences and Humanities panels. Greater disagreement was observed for proposals with lower average IER scores. CR scores for proposals with initial disagreement were also significantly lower. Proposals with a large absolute difference between the average IER and CR scores (≥10 points; n=368, 1.5%) generally had lower CR scores. An inter-correlation matrix of individual raters' scores of evaluation criteria of proposals indicated that these scores were, in general, a reflection of raters' overall scores. Our analysis demonstrated a good internal consistency and general high agreement among raters. Consensus meetings appear to be relevant for particular panels and subsets of proposals with large differences among raters' scores.

  20. Mechanisms of action of brief alcohol interventions remain largely unknown – A narrative review

    Directory of Open Access Journals (Sweden)

    Jacques eGaume

    2014-08-01

    Full Text Available A growing body of evidence has shown efficacy of brief intervention (BI for hazardous and harmful alcohol use in primary health care settings. Evidence for efficacy in other settings, and effectiveness when implemented at larger scale is disappointing. Indeed, BI comprises varying content, and exploring BI content and mechanisms of action may be a promising way to enhance efficacy and effectiveness.We searched Medline and PsychInfo, as well as references of retrieved publications for original research or reviews on active ingredients (or components, or mechanisms of face-to-face BIs (and its subtypes, including brief advice and brief motivational interviewing [BMI] for alcohol. Overall, BI active ingredients have been scarcely investigated, almost only within BMI, and mostly among Emergency Room patients, young adults, and US college students. This body of research has shown that personalized feedback may be an effective component; specific MI techniques showed mixed findings; decisional balance findings tended to suggest a potential detrimental effect; while change plan exercises, advice to reduce or stop drinking, presenting alternative change options, and moderation strategies are promising but need further study. Client change talk is a potential mediator of BMI effects; change in norm perceptions and enhanced discrepancy between current behavior and broader life goals and values have received preliminary support; readiness to change was only partially supported as a mediator; while enhanced awareness of drinking, perceived risks/benefits of alcohol use, alcohol treatment seeking, and self-efficacy were seldom studied and have as yet found no significant support as such.Research is obviously limited and has provided no clear and consistent evidence on the mechanisms of alcohol BI. How BI achieves the effects seen in randomized trials remains mostly unknown and should be investigated to inform the development of more effective interventions.

  1. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action.

    Science.gov (United States)

    Lopresti, Adrian L; Drummond, Peter D

    2014-11-01

    Saffron, a spice derived from the flower of Crocus sativus, has now undergone several trials examining its antidepressant effects and, in a recent meta-analysis, was confirmed to be effective for the treatment of major depression. To provide an expanded systematic analysis of the completed clinical studies on saffron and depression, detailing dosages, extract sources, standardisations, safety profile and treatment duration; and, through a narrative review, to examine its potential antidepressant mechanisms of action. In the systematic review of clinical trials, electronic databases were searched for high-quality, randomised, double-blind studies, with placebo or antidepressant controls. A narrative review of in vivo and in vitro studies was conducted to examine its potential antidepressant mechanisms of action. In the systematic review, six studies were identified. In the placebo-comparison trials, saffron had large treatment effects and, when compared with antidepressant medications, had similar antidepressant efficacy. Saffron's antidepressant effects potentially are due to its serotonergic, antioxidant, anti-inflammatory, neuro-endocrine and neuroprotective effects. Research conducted so far provides initial support for the use of saffron for the treatment of mild-to-moderate depression. Further research is required to expand our understanding of the role and actions of saffron in major depression. Copyright © 2014 John Wiley & Sons, Ltd.

  2. Draft Test Guideline: Whole Sediment Acute Toxicity Invertebrates, Marine

    Science.gov (United States)

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  3. The Innovation Paradox: A Selective Review of the Literature on Action Learning and Innovation

    Science.gov (United States)

    Pedler, Mike; Brook, Cheryl

    2017-01-01

    This paper explores selective literatures in the two fields of action learning and innovation, and seeks insights into the processes of, and connections between, innovation, engagement and implementation. We searched the action learning articles for references to innovation, beginning with the work of Revans, who highlights the innovation paradox,…

  4. Impact of safety-related regulatory action on clinical practice : a systematic review

    NARCIS (Netherlands)

    Piening, S.; Haaijer-Ruskamp, F.M.; de Vries, J.T.; van der Elst, M.E.; de Graeff, P.A.; Straus, S.M.; Mol, P.G.

    2012-01-01

    Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of

  5. Impact of Safety-Related Regulatory Action on Clinical Practice A Systematic Review

    NARCIS (Netherlands)

    Piening, Sigrid; Haaijer-Ruskamp, Flora M.; de Vries, Jonie T. N.; van der Elst, Menno E.; de Graeff, Pieter A.; Straus, Sabine M. J. M.; Mol, Peter G. M.

    2012-01-01

    Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of

  6. 16 CFR 1021.4 - Overview of environmental review process for CPSC actions.

    Science.gov (United States)

    2010-01-01

    ... detailed fashion. (See § 1021.10(a), below.) It contains sufficient information to form a basis for... Commission at the time it considers the proposed action and is available to the public when the notice of... statements. When CPSC makes changes in the proposed action that are important to environmental issues or when...

  7. Using Rapid Improvement Events for Disaster After-Action Reviews: Experience in a Hospital Information Technology Outage and Response.

    Science.gov (United States)

    Little, Charles M; McStay, Christopher; Oeth, Justin; Koehler, April; Bookman, Kelly

    2018-02-01

    The use of after-action reviews (AARs) following major emergency events, such as a disaster, is common and mandated for hospitals and similar organizations. There is a recurrent challenge of identified problems not being resolved and repeated in subsequent events. A process improvement technique called a rapid improvement event (RIE) was used to conduct an AAR following a complete information technology (IT) outage at a large urban hospital. Using RIE methodology to conduct the AAR allowed for the rapid development and implementation of major process improvements to prepare for future IT downtime events. Thus, process improvement methodology, particularly the RIE, is suited for conducting AARs following disasters and holds promise for improving outcomes in emergency management. Little CM , McStay C , Oeth J , Koehler A , Bookman K . Using rapid improvement events for disaster after-action reviews: experience in a hospital information technology outage and response. Prehosp Disaster Med. 2018;33(1):98-100.

  8. BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety.

    Science.gov (United States)

    Fox, Robert J; Kita, Mariko; Cohan, Stanley L; Henson, Lily Jung; Zambrano, Javier; Scannevin, Robert H; O'Gorman, John; Novas, Mark; Dawson, Katherine T; Phillips, J Theodore

    2014-02-01

    Multiple sclerosis (MS) is a chronic inflammatory disease, affecting more than 2.5 million people worldwide with more 400,000 cases in the United States alone. There has been considerable improvement in the treatment of MS, with the introduction of disease-modifying drugs; however, new oral therapies may provide additional benefit by providing an alternative treatment modality and the potential for improved adherence by avoiding the injection-associated side effects and anxiety encountered with some first-line agents. BG-12 (dimethyl fumarate) is an oral agent approved in the United States for the treatment of relapsing forms of MS. We review published literature about what is known about the mechanism of action of BG-12, and key efficacy and safety findings from three clinical studies in patients with relapsing-remitting MS (RRMS). Data from preclinical studies have demonstrated that BG-12 may promote anti-inflammatory and cytoprotective activities that are mediated, at least in part, by the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) antioxidant response pathway. Studies in animals have shown a protective effect of BG-12 on neuronal, axonal and myelin integrity. Results from a phase 2 study and two randomized double-blind placebo-controlled phase 3 studies, CONFIRM and DEFINE, have shown that BG-12 provides clinical and radiologic efficacy in patients with RRMS. At 2 years, BG-12 240 mg twice and three times daily reduced annualized relapse rate (CONFIRM primary endpoint) by 44% and 51% and the risk of relapse (DEFINE primary endpoint) by 49% and 50%, respectively, compared with placebo (all p < 0.001). BG-12 was generally well tolerated and had an acceptable safety profile, with a similar incidence of adverse events across treatment groups. BG-12 may have cytoprotective and anti-inflammatory properties that contribute to its efficacy among patients with RRMS. Findings from phase 2 and 3 studies further support BG-12 as an effective initial therapy

  9. Review: Jean McNiff & Jack Whitehead (2006. All You Need to Know About Action Research

    Directory of Open Access Journals (Sweden)

    Sunil Khanna

    2007-09-01

    Full Text Available This book serves as a comprehensive guide to action research. It provides useful information on how to undertake an action research project, write reports and disseminate research findings. Specifically, it explains how to identify a research question, map out an action plan, use appropriate methodologies and generate evidence from the data to test findings against the most stringent critiques. In doing so, the book provides justification for action research and its potential scholarly benefits. The book achieves most of the objectives set out by the authors in the introductory section. The strength of the book is reflected in the authors' skillful organization of key concepts in a manner that follows a logical order. Chapters, sections, and subsections respond to questions posed at the beginning of each section. The use of examples and case studies is especially helpful in educating researchers about all aspects associated with "doing action research." The book is written more for a practitioner-scholar than for scholar-practitioner. However, the book only marginally succeeds in contextualizing action research in the larger theoretical and interdisciplinary discourse. URN: urn:nbn:de:0114-fqs070382

  10. Neurocognitive mechanisms of perception-action coordination: a review and theoretical integration.

    Science.gov (United States)

    Ridderinkhof, K Richard

    2014-10-01

    The present analysis aims at a theoretical integration of, and a systems-neuroscience perspective on, a variety of historical and contemporary views on perception-action coordination (PAC). We set out to determine the common principles or lawful linkages between sensory and motor systems that explain how perception is action-oriented and how action is perceptually guided. To this end, we analyze the key ingredients to such an integrated framework, examine the architecture of dual-system conjectures of PAC, and endeavor in an historical analysis of the key characteristics, mechanisms, and phenomena of PACs. This analysis will reveal that dual-systems views are in need of fundamental re-thinking, and its elements will be amalgamated with current views on action-oriented predictive processing into a novel integrative theoretical framework (IMPPACT: Impetus, Motivation, and Prediction in Perception-Action Coordination theory). From this framework and its neurocognitive architecture we derive a number of non-trivial predictions regarding conative, motive-driven PAC. We end by presenting a brief outlook on how IMPPACT might present novel insights into certain pathologies and into action expertise. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Complementary Actions

    Directory of Open Access Journals (Sweden)

    Luisa eSartori

    2015-05-01

    Full Text Available Complementary colors are color pairs which, when combined in the right proportions, produce white or black. Complementary actions refer here to forms of social interaction wherein individuals adapt their joint actions according to a common aim. Notably, complementary actions are incongruent actions. But being incongruent is not sufficient to be complementary (i.e., to complete the action of another person. Successful complementary interactions are founded on the abilities: (i to simulate another person’s movements, (ii to predict another person’s future action/s, (iii to produce an appropriate incongruent response which differ, while interacting, with observed ones, and (iv to complete the social interaction by integrating the predicted effects of one’s own action with those of another person. This definition clearly alludes to the functional importance of complementary actions in the perception–action cycle and prompts us to scrutinize what is taking place behind the scenes. Preliminary data on this topic have been provided by recent cutting-edge studies utilizing different research methods. This mini-review aims to provide an up-to-date overview of the processes and the specific activations underlying complementary actions.

  12. Minutes from Department of Energy/Hazardous Waste Remedial Actions Program, research and development technology needs assessment review meeting for FY 1990, September 1989, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    1990-08-01

    On September 20--21, 1989, representatives of the Department of Energy (DOE) Headquarters, DOE Operations Offices, DOE contractors, and the Hazardous Waste Remedial Actions Program met in Oak Ridge, Tennessee, to select and prioritize candidate waste problems in need of research and development. The information gained will be used in planning for future research and development tasks and in restructuring current research activities to address the priority needs. Consistent with the ongoing reevaluation of DOE's plans for environmental restoration and waste management, an attempt was made to relate the needs developed in this meeting to the needs expressed in the draft Applied Research, Development, Demonstration, Testing, and Evaluation Plan. Operations Offices were represented either by DOE staff or by contractor delegates from the area. This document summarizes the results of the meeting and lists the priority waste problems established.

  13. A conceptual review on action-perception coupling in the musicians’ brain: what is it good for?

    Science.gov (United States)

    Novembre, Giacomo; Keller, Peter E.

    2014-01-01

    Experience with a sensorimotor task, such as practicing a piano piece, leads to strong coupling of sensory (visual or auditory) and motor cortices. Here we review behavioral and neurophysiological (M/EEG, TMS and fMRI) research exploring this topic using the brain of musicians as a model system. Our review focuses on a recent body of evidence suggesting that this form of coupling might have (at least) two cognitive functions. First, it leads to the generation of equivalent predictions (concerning both when and what event is more likely to occur) during both perception and production of music. Second, it underpins the common coding of perception and action that supports the integration of the motor output of multiple musicians’ in the context of joint musical tasks. Essentially, training-based coupling of perception and action might scaffold the human ability to represent complex (structured) actions and to entrain multiple agents—via reciprocal prediction and adaptation—in the pursuit of shared goals. PMID:25191246

  14. A Conceptual Review on Action-Perception Coupling in the Musicians’ Brain: What Is It Good for?

    Directory of Open Access Journals (Sweden)

    Giacomo eNovembre

    2014-08-01

    Full Text Available Experience with a sensorimotor task, such as practicing a piano piece, leads to strong coupling of sensory (visual or auditory and motor cortices. Here we review behavioural and neurophysiological (M/EEG, TMS and fMRI research exploring this topic using the brain of musicians as a model system. Our review focuses on a recent body of evidence suggesting that this form of coupling might have (at least two cognitive functions. First, it leads to the generation of equivalent predictions (concerning both when and what event is more likely to occur during both perception and production of music. Second, it underpins the common coding of perception and action that supports the integration of the motor output of multiple musicians’ in the context of joint musical tasks. Essentially, training-based coupling of perception and action might scaffold the human ability to represent complex (structured actions and to entrain multiple agents – via reciprocal prediction and adaptation – in the pursuit of shared goals.

  15. A conceptual review on action-perception coupling in the musicians' brain: what is it good for?

    Science.gov (United States)

    Novembre, Giacomo; Keller, Peter E

    2014-01-01

    Experience with a sensorimotor task, such as practicing a piano piece, leads to strong coupling of sensory (visual or auditory) and motor cortices. Here we review behavioral and neurophysiological (M/EEG, TMS and fMRI) research exploring this topic using the brain of musicians as a model system. Our review focuses on a recent body of evidence suggesting that this form of coupling might have (at least) two cognitive functions. First, it leads to the generation of equivalent predictions (concerning both when and what event is more likely to occur) during both perception and production of music. Second, it underpins the common coding of perception and action that supports the integration of the motor output of multiple musicians' in the context of joint musical tasks. Essentially, training-based coupling of perception and action might scaffold the human ability to represent complex (structured) actions and to entrain multiple agents-via reciprocal prediction and adaptation-in the pursuit of shared goals.

  16. 75 FR 39493 - United States Patent and Trademark Office Draft Strategic Plan for FY 2010-2015

    Science.gov (United States)

    2010-07-09

    ... United States Patent and Trademark Office United States Patent and Trademark Office Draft Strategic Plan...) draft strategic plan for fiscal years (FY) 2010-2015 is available for public review and comment. The... administration and leadership of the agency is a revision of the FY 2007-2012 strategic plan. The USPTO's current...

  17. Ascaris suum draft genome.

    Science.gov (United States)

    Jex, Aaron R; Liu, Shiping; Li, Bo; Young, Neil D; Hall, Ross S; Li, Yingrui; Yang, Linfeng; Zeng, Na; Xu, Xun; Xiong, Zijun; Chen, Fangyuan; Wu, Xuan; Zhang, Guojie; Fang, Xiaodong; Kang, Yi; Anderson, Garry A; Harris, Todd W; Campbell, Bronwyn E; Vlaminck, Johnny; Wang, Tao; Cantacessi, Cinzia; Schwarz, Erich M; Ranganathan, Shoba; Geldhof, Peter; Nejsum, Peter; Sternberg, Paul W; Yang, Huanming; Wang, Jun; Wang, Jian; Gasser, Robin B

    2011-10-26

    Parasitic diseases have a devastating, long-term impact on human health, welfare and food production worldwide. More than two billion people are infected with geohelminths, including the roundworms Ascaris (common roundworm), Necator and Ancylostoma (hookworms), and Trichuris (whipworm), mainly in developing or impoverished nations of Asia, Africa and Latin America. In humans, the diseases caused by these parasites result in about 135,000 deaths annually, with a global burden comparable with that of malaria or tuberculosis in disability-adjusted life years. Ascaris alone infects around 1.2 billion people and, in children, causes nutritional deficiency, impaired physical and cognitive development and, in severe cases, death. Ascaris also causes major production losses in pigs owing to reduced growth, failure to thrive and mortality. The Ascaris-swine model makes it possible to study the parasite, its relationship with the host, and ascariasis at the molecular level. To enable such molecular studies, we report the 273 megabase draft genome of Ascaris suum and compare it with other nematode genomes. This genome has low repeat content (4.4%) and encodes about 18,500 protein-coding genes. Notably, the A. suum secretome (about 750 molecules) is rich in peptidases linked to the penetration and degradation of host tissues, and an assemblage of molecules likely to modulate or evade host immune responses. This genome provides a comprehensive resource to the scientific community and underpins the development of new and urgently needed interventions (drugs, vaccines and diagnostic tests) against ascariasis and other nematodiases. ©2011 Macmillan Publishers Limited. All rights reserved

  18. AGILE DRAFTING OF OUTSOURCING CONTRACTS

    DEFF Research Database (Denmark)

    Schlichter, Bjarne Rerup; Storgaard, Kristian

    2015-01-01

    The concept of ‘agility’ has become quite popular in the development of IT-artefacts and has created interest in the more general project management literature. The process of drafting complex contracts for large IT projects (service as well as software) is often done under time pressure and in s......The concept of ‘agility’ has become quite popular in the development of IT-artefacts and has created interest in the more general project management literature. The process of drafting complex contracts for large IT projects (service as well as software) is often done under time pressure...... and in several parallel tracks using different competencies. By the use of an illustrative case-study, this paper explores how scrum can be applied to enhance the process of drafting outsourcing contracts. The analysis indicates that the use of an agile method, such as Scrum, can be beneficial in this context...

  19. 49 CFR 229.61 - Draft system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Draft system. 229.61 Section 229.61 Transportation... TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Draft System § 229.61 Draft system. (a) A.... Suspension System ...

  20. Mechnical Drawing/Drafting Curriculum Guide.

    Science.gov (United States)

    Gregory, Margaret R.; Benson, Robert T.

    This curriculum guide consists of materials for teaching a course in mechanical drawing and drafting. Addressed in the individual units of the guide are the following topics: the nature and scope of drawing and drafting, visualization and spatial relationships, drafting tools and materials, linework, freehand lettering, geometric construction,…

  1. Book Review ~ Action learning: Images and pathways. Author: Robert L. Dilworth and Verna J. Willis

    Directory of Open Access Journals (Sweden)

    Reviewed by Patrick J. Fahy

    2003-10-01

    Full Text Available Action learning, as defined in this book, is “a process of reflecting on one’s work and beliefs in the supportive/ confrontational environment of one’s peers for the purpose of gaining new insights and resolving real business and community problems in real time” (p. 11. The claims made for action learning are impressive. Action learning: * Allows participants (who work in groups called sets to answer the question, “What is an honest man, and what do I need to do to become one?” (p. viii. * Is more than learning by doing, action learning “has the potential for putting control of lifelong learning directly in the hands of learners, in ways that alter their perceptions, amplify self-efficacy, and re-connect these individuals to spontaneous curiosity and confidence in the exercise of their own good judgment” (p. xi. * Is a “sleeping giant in the catalogue of individual and organizational change strategies” (p. xi. * Is believed to address the five most important needs facing organizations today: 1 problem-solving; 2 organizational learning; 3 leadership development; 4 professional growth; and 5 career development (p. xiii.

  2. A Critical Review of Mode of Action (MOA) Assignment Classifications for Ecotoxicology

    Science.gov (United States)

    There are various structure-based classification schemes to categorize chemicals based on mode of action (MOA) which have been applied for both eco and human health toxicology. With increasing calls to assess thousands of chemicals, some of which have little available informatio...

  3. May spa therapy be a valid opportunity to treat hand osteoarthritis? A review of clinical trials and mechanisms of action.

    Science.gov (United States)

    Fortunati, Nicola Angelo; Fioravanti, Antonella; Seri, Gina; Cinelli, Simone; Tenti, Sara

    2016-01-01

    Osteoarthritis (OA) is the most common form of arthritis and its current treatment includes non-pharmacological and pharmacological modalities. Spa therapy represents a popular treatment for many rheumatic diseases. The aim of this review was to summarize the currently available information on clinical effects and mechanisms of action of spa therapy in OA of the hand. We conducted a search of the literature to extract articles describing randomized clinical trials (RCTs) in hand OA published in the period 1952-2015. We identified three assessable articles reporting RCTs on spa therapy in hand OA. Data from these clinical trials support a beneficial effect of spa therapy on pain, function and quality of life in hand OA. Spa therapy seems to have a role in the treatment of hand OA. However, additional RCTs are necessary to clarify the mechanisms of action and the effects of the application of thermal treatments.

  4. Two physiotherapists, one librarian and a systematic literature review: collaboration in action.

    Science.gov (United States)

    Swinkels, Annette; Briddon, Jason; Hall, Jane

    2006-12-01

    This paper explores the processes of collaboration between a librarian and two academic physiotherapists working on a systematic review jointly funded by the University of the West of England (UWE), Bristol, and the Royal National Hospital for Rheumatic Diseases (RNHRD), Bath, UK. The aim of this paper is to describe and evaluate some of the processes of collaboration between the three authors in their work in progress on a funded systematic literature review on the topic of hydrotherapy and pain. The vehicle for describing and analysing these processes is a joint (National Health Service Trust and University) funded systematic literature review currently in progress on the topic of hydrotherapy and pain. Systematic review methodology is becoming increasingly complex and is rapidly developing its own research base. Librarian input is a key element in a successful systematic review. Systematic reviews play a critical role in informing healthcare delivery and research in the UK. The individual nature and inherent complexity of each review demands close collaboration between librarians, academics and clinicians. In addition to enhancing the reviews themselves, there are many other personal and institutional benefits of collaborative working. Consideration may need to be given to library staff structures and roles if these benefits are to be maximized and sustained.

  5. The What, the When, and the Whether of Intentional Action in the Brain: A Meta-Analytical Review

    Directory of Open Access Journals (Sweden)

    Laura Zapparoli

    2017-05-01

    Full Text Available In their attempt to define discrete subcomponents of intentionality, Brass and Haggard (2008 proposed their What, When, and Whether model (www-model which postulates that the content, the timing and the possibility of generating an action can be partially independent both at the cognitive level and at the level of their neural implementation. The original proposal was based on a limited number of studies, which were reviewed with a discursive approach. To assess whether the model stands in front of the more recently published data, we performed a systematic review of the literature with a meta-analytic method based on a hierarchical clustering (HC algorithm. We identified 15 PET/fMRI studies well-suited for this quest. HC revealed the existence of a rostro-caudal gradient within the medial prefrontal cortex, with the more anterior regions (the anterior cingulum involved in more abstract decisions of whether to execute an action and the more posterior ones (the middle cingulum or the SMA recruited in specifying the content and the timing components of actions. However, in contrast with the original www-model, this dissociation involves also brain regions well outside the median wall of the frontal lobe, in a component specific manner: the supramarginal gyrus for the what component, the pallidum and the thalamus for the when component, the putamen and the insula for the whether component. We then calculated co-activation maps on the three component-specific www clusters of the medial wall of the frontal/limbic lobe: to this end, we used the activation likelihood approach that we applied on the imaging studies on action contained in the BrainMap.org database. This analysis confirmed the main findings of the HC analyses. However, the BrainMap.org data analyses also showed that the aforementioned segregations are generated by paradigms in which subjects act in response to conditional stimuli rather than while driven by their own intentions. We

  6. 42 CFR 137.374 - Does the Secretary have a role in reviewing or monitoring a Self-Governance Tribe's actions in...

    Science.gov (United States)

    2010-10-01

    ... monitoring a Self-Governance Tribe's actions in acquiring or leasing real property with funds provided under... SELF-GOVERNANCE Construction Other § 137.374 Does the Secretary have a role in reviewing or monitoring a Self-Governance Tribe's actions in acquiring or leasing real property with funds provided under a...

  7. Accelerating Cleanup: Focus on 2006. Discussion draft

    Energy Technology Data Exchange (ETDEWEB)

    None

    1997-06-01

    This executive summary addresses the activities associated with the National Transuranic (TRU) Program managed by the Carlsbad Area Office (CAO). The CAO programmatically reports to the Assistant Secretary for Environmental Management and receives administrative support through the Albuquerque Operations Office. The mission of the Carlsbad Area Office (CAO) is to protect human health and the environment by opening and operating the Waste Isolation Pilot Plant for site disposal of TRU waste and by establishing an effective system for management of TRU waste from generation to disposal. It includes personnel assigned to the CAO, the Waste Isolation Pilot Plant (WIPP) site operations, and other activities associated with the National TRU Program. The CAO develops and directs implementation of the program, while the DOE Headquarters establishes policy and guidelines. The CAO assesses compliance with the program guidance, as well as the commonality of activities and assumptions among all the sites. Since the development of the February 28, 1997, database used to develop this Discussion Draft, the opening of the WIPP facility for receipt of Contact Handled waste has been delayed from November 1997 to May 1998. This slippage is significant enough to require a change in the milestones and volumes included in the documents to be reviewed by our stakeholders. Changes have been incorporated into this Discussion Draft and its supporting Project Baseline Summaries (PBSs).

  8. Review of maintenance, start-up, shutdown activities by Region 6 of the Texas Commission on Environmental Quality draft model permit

    Science.gov (United States)

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  9. [The protective action of cytokinins on the photosynthetic apparatus and productivity of plants under stress (review)].

    Science.gov (United States)

    Cherniad'ev, I I

    2009-01-01

    A putative way of the protective action of cytokinins on the photosynthetic processes in crops experiencing various stress factors is considered. Various cytokinins are characterized. Pathways of the multiple effects of cytokinin preparations mediating the protection of the photosynthetic machinery from stress are described. Cytokinins interact with receptor proteins, and then the signal is transduced to primary cellular targets (primary response genes). These genes, which possess receptor domains, induce synthesis of the corresponding mRNAs and photosynthesis-related proteins of chlorophyll-protein complexes, the electron-transport chain, and carbon metabolism, primarily, the key enzyme ribulose bisphosphate carboxylase/oxygenase. The protective action of cytokinins under stress conditions preserves the structure and function of the photosynthetic apparatus. The application of cytokinins to improving crop yields is discussed.

  10. Mechanism of Action of Ulipristal Acetate for Emergency Contraception: A Systematic Review

    Science.gov (United States)

    Rosato, Elena; Farris, Manuela; Bastianelli, Carlo

    2016-01-01

    Ulipristal acetate (UPA) is now recommended as first choice hormonal emergency contraception (EC), due to its higher efficacy and similar safety compared to Levonorgestrel – EC. Even though all trials demonstrated that the first mechanism of action is inhibition of ovulation, some authors still postulate that a post fertilization effect is also possible, raising the alert on medication and fostering the ethical debate. A Medline database search was performed in order to find recent articles related to UPA’s effects on ovulation, on fallopian tube and on endometrium. We also analyzed the effects on sperm function and pregnancy. All studies conclude that UPA is effective in inhibition of ovulation even when administered shortly before LH peak. The effects on fallopian tube are unclear: according to some authors UPA inhibits ciliar beat through an agonistic effect on progesterone receptors, according to others it antagonizes the progesterone-induced ciliar beat decrease. Concerning the action on endometrium and on embryo implantation most of the studies concluded that low dose UPA used for EC has no significant effect on the decrease of endometrial thickness and on embryo’s attachment, but these results are still matter of debate. Finally recent evidence suggests that UPA modulates human sperm functions while it has no effect on established pregnancy. To date the majority of the evidence concurs in excluding a post-fertilization effect of UPA, even though more studies are needed to clarify its mechanism of action. PMID:26793107

  11. Probiotics as beneficial microbes in aquaculture: an update on their multiple modes of action: a review.

    Science.gov (United States)

    Zorriehzahra, Mohammad Jalil; Delshad, Somayeh Torabi; Adel, Milad; Tiwari, Ruchi; Karthik, K; Dhama, Kuldeep; Lazado, Carlo C

    2016-12-01

    Wide and discriminate use of antibiotics has resulted in serious biological and ecological concerns, especially the emergence of antibiotic resistance. Probiotics, known as beneficial microbes, are being proposed as an effective and eco-friendly alternative to antibiotics. They were first applied in aquaculture species more than three decades ago, but considerable attention had been given only in the early 2000s. Probiotics are defined as live or dead, or even a component of the microorganisms that act under different modes of action in conferring beneficial effects to the host or to its environment. Several probiotics have been characterized and applied in fish and a number of them are of host origin. Unlike some disease control alternatives being adapted and proposed in aquaculture where actions are unilateral, the immense potential of probiotics lies on their multiple mechanisms in conferring benefits to the host fish and the rearing environment. The staggering number of probiotics papers in aquaculture highlights the multitude of advantages from these microorganisms and conspicuously position them in the dynamic search for health-promoting alternatives for cultured fish. This paper provides an update on the use of probiotics in finfish aquaculture, particularly focusing on their modes of action. It explores the contemporary understanding of their spatial and nutritional competitiveness, inhibitory metabolites, environmental modification capability, immunomodulatory potential and stress-alleviating mechanism. This timely update affirms the importance of probiotics in fostering sustainable approaches in aquaculture and provides avenues in furthering its research and development.

  12. The actions of Occupational Therapy with adolescents in situations of social vulnerability: a literature review

    Directory of Open Access Journals (Sweden)

    Janaína de Souza Sabino

    2017-09-01

    Full Text Available Objective: This research aims to describe the actions of Occupational Therapy with adolescents in situations of social vulnerability and analyze how the professional contribution in the social field. Method: This is a bibliographical research of indexed articles made through consultations the data platform of the Virtual Health Library, the Occupational Therapy Magazines of the University of São Paulo and the Cadernos de Terapia Ocupacional of the Federal University of São Carlos. The following health descriptors (DeCS were used: Occupational Therapy AND adolescents AND social vulnerability. We included original articles, experience reports and case studies on Occupational Therapy actions/interventions among adolescents in situations of social vulnerability in Brazil between 2005 and 2015. Results: A total of 48 articles were found, of which 39 were excluded because they did not meet the inclusion criteria of the research and 9 were read in full and analyzed. The strategies used by Occupational Therapy consisted of workshops of activities, dynamics and group discussion. These strategies have provided important results for this population, for example: strengthening of bonds, improved communication, relaxed behavior of adolescents, appropriation of rights, exercise of autonomy and realization of personal projects. Conclusion: The literature found provides support for insertion and implementation of Occupational Therapy actions with adolescents in situations of social vulnerability.

  13. Mechanism of action of ulipristal acetate for emergency contraception: a systematic review

    Directory of Open Access Journals (Sweden)

    Elena eRosato

    2016-01-01

    Full Text Available SUMMARYUlipristal acetate (UPA is now recommended as first choice hormonal Emergency Contraception (EC, due to its higher efficacy and similar safety compared to Levonogestrel - EC. Even though all trials demonstrated that the first mechanism of action is inhibition of ovulation, some authors still postulate that a post fertilization effect is also possible, raising the alert on medication and fostering the ethical debate.A Medline database search was performed in order to find recent articles related to UPA’s effects on ovulation, on fallopian tube and on endometrium. We also analyzed the effects on sperm function and pregnancy. All studies conclude that UPA is effective in inhibition of ovulation even when administered shortly before LH peak. The effects on fallopian tube are unclear: according to some authors UPA inhibits ciliar beat through an agonistic effect on progesterone receptors, according to others it antagonizes the progesterone-induced ciliar beat decrease. Concerning the action on endometrium and on embryo implantation most of the studies concluded that low dose UPA used for EC has no significant effect on the decrease of endometrial thickness and on embryo’s attachment, but these results are still matter of debate. Finally recent evidence suggests that UPA modulates human sperm functions while it has no effect on established pregnancy. To date the majority of the evidence concur in excluding a post-fertilization effect of UPA, even though more studies are needed to clarify its mechanism of action.

  14. Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat-Systematic review.

    Science.gov (United States)

    Modena, Débora A Oliveira; da Silva, Caroline Nogueira; Grecco, Clovis; Guidi, Renata Michelini; Moreira, Renata Gomes; Coelho, Andresa A; Sant'Ana, Estela; de Souza, José Ricardo

    2017-10-01

    Extracorporeal Shockwave Therapy (ESWT) has had a wide use in rehabilitation, and has presented positive effects in the treatment of unaesthetic affections. The objective of the present study was to search, in the literature, the mechanisms of action and the physiological aspects of shockwaves acting on the biological tissue to improve the condition of cellulite and localized fat. The systematic review of the literature was carried out in the period of September 2016 to February 2017 based on the bibliographic databases such as Lilacs, Medline, PubMed, and SciELO. Fifteen articles were identified in that systematic review, three of which were excluded as they did not make the complete access to the article available or the theme investigated did not encompass the objective of the study. The revision demonstrated that extracorporeal shockwaves present relevant effects on the biological tissue, which leads to the restructuring of skin properties and subcutaneous tissue, thus clinically improving the aspects of cellulite and localized fat.

  15. 78 FR 70040 - Draft Integrated Science Assessment for Nitrogen Oxides-Health Criteria

    Science.gov (United States)

    2013-11-22

    ... policy or views. EPA will consider any public comments submitted in response to this notice when revising... and external to EPA, key science and policy issues relevant to the review of the health effects of... of the review, and the key policy-relevant science issues that will guide the review. The draft IRP...

  16. Gentiana scabra Bunge. Formula for Herpes Zoster: Biological Actions of Key Herbs and Systematic Review of Efficacy and Safety.

    Science.gov (United States)

    Wang, Kaiyi; Coyle, Meaghan E; Mansu, Suzi; Zhang, Anthony Lin; Xue, Charlie Changli

    2017-03-01

    This study reviewed the biological action of key herbs and evaluated systematically the efficacy and safety of oral Gentiana formula for herpes zoster (HZ). Experimental studies relevant to HZ were identified in PubMed. Randomized controlled trials using Gentiana formula for HZ were identified from nine English and Chinese databases. The primary outcome was evaluation of pain. Potential risk of bias was assessed. Meta-analysis was conducted using mean difference or risk ratio with 95% confidence intervals. Key herbs Gentiana scabra Bunge, Gentiana triflora Pall, Scutellaria baicalensis Georgi, and Gardenia jasminoides Ellis have shown antiinflammatory actions through inhibition of inflammatory cytokines and pro-inflammatory enzymes. Twenty-six clinical studies, involving 2955 participants, were included. Modified Gentiana formula resolved pain earlier than pharmacotherapy when used alone or combined with topical Chinese herbal medicine. Incidence of postherpetic neuralgia was lower (risk ratio 0.14, 95% confidence interval 0.03 to 0.74) with modified Gentiana formula plus topical Chinese herbal medicine. Mild adverse events were reported. Antiinflammatory actions of key herbs of Gentiana formula may explain clinical benefit in hastening pain relief and decreasing postherpetic neuralgia. Few adverse events were reported. Findings were limited by study quality and diversity in intervention and comparator dosage. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  17. A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

    Directory of Open Access Journals (Sweden)

    Hao Sun

    2016-08-01

    Full Text Available AbstractRhein is a major medicinal ingredient isolated from several traditional Chinese medicines, including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and Polygonum multiflorum Thunb. Rhein has various pharmacological activities, such as anti-inflammatory, antitumor, antioxidant, antifibrosis, hepatoprotective, and nephroprotective activities. Although more than 100 articles in PubMed are involved in the pharmacological mechanism of action of rhein, only a few focus on the relationship of crosstalk among multiple pharmacological mechanisms. The mechanism of rhein involves multiple pathways which contain close interactions. From the overall perspective, the pathways which are related to the targets of rhein, are initiated by the membrane receptor. Then, MAPK and PI3K-AKT parallel signaling pathways are activated, and several downstream pathways are affected, thereby eventually regulating cell cycle and apoptosis. The therapeutic effect of rhein, as a multitarget molecule, is the synergistic and comprehensive result of the involvement of multiple pathways rather than the blocking or activation of a single signaling pathway. We review the pharmacological mechanisms of action of rhein by consulting literature published in the last 100 years in PubMed. We then summarize these pharmacological mechanisms from a comprehensive, interactive, and crosstalk perspective. In general, the molecular mechanism of action of drug must be understood from a systematic and holistic perspective, which can provide a theoretical basis for precise treatment and rational drug use.

  18. Tools for Assessment of Communication Skills of Hospital Action Teams: A Systematic Review.

    Science.gov (United States)

    Rehim, Shady A; DeMoor, Stephanie; Olmsted, Richard; Dent, Daniel L; Parker-Raley, Jessica

    Hospital action teams comprise interdisciplinary health care providers working simultaneously to treat critically ill patients. Assessments designed to evaluate communication effectiveness or "nontechnical" performance of these teams are essential to minimize medical errors and improve team productivity. Although multiple communication tools are available, the characteristics and psychometric validity of these instruments have yet to be systematically compared. To identify assessments used to evaluate the communication or "nontechnical" performance of hospital action teams and summarize evidence to develop and validate these instruments. A literature search was conducted using MEDLINE/PubMed database to identify original articles related to assessment of communication skills in teams working in acute care medicine not exclusive to emergency room, operating room, prehospital air and ground transport, or code blue/rapid response resuscitations. Ten communication assessment tools were identified. Six tools (60%) were designed to measure communication performance of the whole team, whereas 4 tools (40%) were created to assess individual team member's communication skills. Regardless of the type of analysis, the most commonly assessed behavior domains were Leadership, Teamwork, Communication, and Situation awareness. Only 1 of 16 articles describing a particular communication assessment tool reported all the validation criteria, other authors underreported efforts to validate their instruments. A number of tools designed to measure the communication or "nontechnical" performance of hospital action teams are available. Unfortunately, limited reported validity evidence may hamper the utility of these tools in actual clinical practice until further validation studies are performed. Copyright © 2017 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  19. Probiotics as beneficial microbes in aquaculture: an update on their multiple modes of action: a review

    DEFF Research Database (Denmark)

    Zorriehzahra, Mohammad Jalil; Delshad, Somayeh Torabi; Adel, Milad

    2016-01-01

    benefits to the host fish and the rearing environment. The staggering number of probiotics papers in aquaculture highlights the multitude of advantages from these microorganisms and conspicuously position them in the dynamic search for health-promoting alternatives for cultured fish. This paper provides...... in aquaculture species more than three decades ago, but considerable attention had been given only in the early 2000s. Probiotics are defined as live or dead, or even a component of the microorganisms that act under different modes of action in conferring beneficial effects to the host or to its environment...

  20. Health Literacy and Health Actions: A Review and a Framework from Health Psychology

    Science.gov (United States)

    von Wagner, Christian; Steptoe, Andrew; Wolf, Michael S.; Wardle, Jane

    2009-01-01

    The association between performance on health literacy measures and health outcomes is well established. The next step is to understand the processes through which health literacy affects health. This review introduces a framework drawing on ideas from health psychology and proposing that associations between health literacy and health outcomes…

  1. Review of ultrasonic irrigation in endodontics: increasing action of irrigating solutions.

    Science.gov (United States)

    Mozo, Sandra; Llena, Carmen; Forner, Leopoldo

    2012-05-01

    Effective irrigant delivery and agitation are prerequisites for successful endodontic treatment. Ultrasonic irrigation can be performed with or without simultaneous ultrasonic instrumentation. Existing literature reveals that ultrasonic irrigation may have a very positive effect on chemical, biological and physical debridement of the root canal system as investigated in many in vitro studies. The purpose of this review article was to summarize and discuss the available information concerning ultrasonic irrigation in endodontics. This article presents an overview of ultrasonic irrigation methods and their debridement efficacy. In this paper the relevant literature on passive ultrasonic irrigation is reviewed. Information from original scientific papers or reviews listed in MEDLINE and Cochrane were included in the review. The use of ultrasound in the irrigation procedure results in improved canal cleanliness, better irrigant transfer to the canal system, soft tissue debridement, and removal of smear layers and bacteria. There are many in vitro studies, but there is a need to standardize protocols, and correlate the clinical efficacy of ultrasonic devices with improved treatment outcomes. Understanding the basis of ultrasonic irrigation is fundamental for clinicians and researchers to improve the design and use of ultrasonic irrigation.

  2. Stylizing Genderlect Online for Social Action: A Corpus Analysis of "BIC Cristal for Her" Reviews

    Science.gov (United States)

    Ray, Brian

    2016-01-01

    This article introduces the concept of stylization and illustrates its usefulness for studying online discourse by examining how writers have employed it in order to parody sexist products such as BIC Cristal for Her, using genderlect in order to introduce dissonance into and reframe patriarchal discourse. A corpus analysis of 671 reviews, written…

  3. 47 CFR 1.115 - Application for review of action taken pursuant to delegated authority.

    Science.gov (United States)

    2010-10-01

    ...) Except as provided in paragraph (e) of this section, the application for review and any supplemental... not, through the exercise of ordinary diligence, have been learned prior to such opportunity. (h)(1... authority for reconsideration in accordance with its instructions, and, if an evidentiary hearing has been...

  4. Review of ultrasonic irrigation in endodontics: increasing action of irrigating solutions

    Science.gov (United States)

    Mozo, Sandra; Llena, Carmen

    2012-01-01

    Introduction: Effective irrigant delivery and agitation are prerequisites for successful endodontic treatment. Ultrasonic irrigation can be performed with or without simultaneous ultrasonic instrumentation. Existing literature reveals that ultrasonic irrigation may have a very positive effect on chemical, biological and physical debridement of the root canal system as investigated in many in vitro studies. Objective: The purpose of this review article was to summarize and discuss the available information concerning ultrasonic irrigation in endodontics. Methods: This article presents an overview of ultrasonic irrigation methods and their debridement efficacy. In this paper the relevant literature on passive ultrasonic irrigation is reviewed. Information from original scientific papers or reviews listed in MEDLINE and Cochrane were included in the review. Results: The use of ultrasound in the irrigation procedure results in improved canal cleanliness, better irrigant transfer to the canal system, soft tissue debridement, and removal of smear layer and bacteria. There are many in vitro studies, but there is a need to standardize protocols, and correlate the clinical efficacy of ultrasonic devices with improved treatment outcomes. Understanding the basis of ultrasonic irrigation is fundamental for clinicians and researchers to improve the design and use of ultrasonic irrigation. Key words:Ultrasonic irrigation, ultrasound, smear layer, endodontics. PMID:22143738

  5. Data Warehouse Governance Programs in Healthcare Settings: A Literature Review and a Call to Action

    OpenAIRE

    Elliott, Thomas E.; Holmes, John H.; Davidson, Arthur J.; La Chance, Pierre-Andre; Nelson, Andrew F.; John F. Steiner

    2013-01-01

    Purpose: Given the extensive data stored in healthcare data warehouses, data warehouse governance policies are needed to ensure data integrity and privacy. This review examines the current state of the data warehouse governance literature as it applies to healthcare data warehouses, identifies knowledge gaps, provides recommendations, and suggests approaches for further research. Methods: A comprehensive literature search using five data bases, journal article title-search, and citation searc...

  6. Data warehouse governance programs in healthcare settings: a literature review and a call to action.

    Science.gov (United States)

    Elliott, Thomas E; Holmes, John H; Davidson, Arthur J; La Chance, Pierre-Andre; Nelson, Andrew F; Steiner, John F

    2013-01-01

    Given the extensive data stored in healthcare data warehouses, data warehouse governance policies are needed to ensure data integrity and privacy. This review examines the current state of the data warehouse governance literature as it applies to healthcare data warehouses, identifies knowledge gaps, provides recommendations, and suggests approaches for further research. A comprehensive literature search using five data bases, journal article title-search, and citation searches was conducted between 1997 and 2012. Data warehouse governance documents from two healthcare systems in the USA were also reviewed. A modified version of nine components from the Data Governance Institute Framework for data warehouse governance guided the qualitative analysis. Fifteen articles were retrieved. Only three were related to healthcare settings, each of which addressed only one of the nine framework components. Of the remaining 12 articles, 10 addressed between one and seven framework components and the remainder addressed none. Each of the two data warehouse governance plans obtained from healthcare systems in the USA addressed a subset of the framework components, and between them they covered all nine. While published data warehouse governance policies are rare, the 15 articles and two healthcare organizational documents reviewed in this study may provide guidance to creating such policies. Additional research is needed in this area to ensure that data warehouse governance polices are feasible and effective. The gap between the development of data warehouses in healthcare settings and formal governance policies is substantial, as evidenced by the sparse literature in this domain.

  7. 46 CFR 97.40-10 - Draft marks and draft indicating systems.

    Science.gov (United States)

    2010-10-01

    ... reliable draft indicating system from which the bow and stern drafts can be determined. ... rudderpost or at any place at the stern of the vessel as may be necessary for easy observation. The bottom of...

  8. 46 CFR 196.40-10 - Draft marks and draft indicating systems.

    Science.gov (United States)

    2010-10-01

    ... reliable draft indicating system from which the bow and stern drafts can be determined. ... rudderpost or at any place at the stern of the vessel as may be necessary for easy observance. The bottom of...

  9. 46 CFR 32.05-1 - Draft marks and draft indicating systems-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... reliable draft indicating system from which the bow and stern drafts can be determined. ... rudderpost or at any place at the stern of the vessel as may be necessary for easy observance. The bottom of...

  10. Physician Burnout and Well-Being: A Systematic Review and Framework for Action.

    Science.gov (United States)

    Rothenberger, David A

    2017-06-01

    Physician burnout in the United States has reached epidemic proportions and is rising rapidly, although burnout in other occupations is stable. Its negative impact is far reaching and includes harm to the burned-out physician, as well as patients, coworkers, family members, close friends, and healthcare organizations. The purpose of this review is to provide an accurate, current summary of what is known about physician burnout and to develop a framework to reverse its current negative impact, decrease its prevalence, and implement effective organizational and personal interventions. I completed a comprehensive MEDLINE search of the medical literature from January 1, 2000, through December 28, 2016, related to medical student and physician burnout, stress, depression, suicide ideation, suicide, resiliency, wellness, and well-being. In addition, I selectively reviewed secondary articles, books addressing the relevant issues, and oral presentations at national professional meetings since 2013. Healthcare organizations within the United States were studied. The literature review is presented in 5 sections covering the basics of defining and measuring burnout; its impact, incidence, and causes; and interventions and remediation strategies. All US medical students, physicians in training, and practicing physicians are at significant risk of burnout. Its prevalence now exceeds 50%. Burnout is the unintended net result of multiple, highly disruptive changes in society at large, the medical profession, and the healthcare system. Both individual and organizational strategies have been only partially successful in mitigating burnout and in developing resiliency and well-being among physicians. Two highly effective strategies are aligning personal and organizational values and enabling physicians to devote 20% of their work activities to the part of their medical practice that is especially meaningful to them. More research is needed.

  11. A Critical Review on the National Energy Efficiency Action Plan of Egypt.

    Directory of Open Access Journals (Sweden)

    Hatem Elrefaei

    2014-03-01

    Full Text Available Egypt, as with other developing countries, faces a major energy security problem, which strongly impacts all national plans for economic development. A sound energy strategy is crucially needed, and should be based on two pillars: first, boosting the production of clean energy from various renewable and non-renewable sources, and second, managing and rationalizing energy demand, with related reforms. Some steps were taken by previous Egyptian governments regarding these two pillars. In February 2008, the Ministry of Electricity and Energy of Egypt put a target of 20% of electricity to come from renewable energy resources by 2020. In July 2012, the Ministerial Cabinet approved both the Egyptian Solar Plan targeting 3500 MW of solar energy by 2027, and the National Energy Efficiency Action Plan (NEEAP to reduce energy consumption 5% during the period from 2012-2015 compared to the average consumption of the previous 5 years. We believe that these plans will not bring their expected fruits unless they are well orchestrated with other sectoral development plans in areas such as agriculture, transport, housing and services, amongst others. This paper aims to investigate the Egyptian NEEAP and assess whether the adopted national energy efficiency plan and the associated policies on all other development sectors adopted by the government have sound implications. We aim to find out whether the development policies with a focus on energy policy are set in an integrated or fragmented way.

  12. Leadership During the Boston Marathon Bombings: A Qualitative After-Action Review.

    Science.gov (United States)

    Goralnick, Eric; Halpern, Pinchas; Loo, Stephanie; Gates, Jonathan; Biddinger, Paul; Fisher, John; Velmahos, George; Chung, Sarita; Mooney, David; Brown, Calvin; Barnewolt, Brien; Burke, Peter; Gupta, Alok; Ulrich, Andrew; Hojman, Horacio; McNulty, Eric; Dorn, Barry; Marcus, Leonard; Peleg, Kobi

    2015-10-01

    On April 15, 2013, two improvised explosive devices (IEDs) exploded at the Boston Marathon and 264 patients were treated at 26 hospitals in the aftermath. Despite the extent of injuries sustained by victims, there was no subsequent mortality for those treated in hospitals. Leadership decisions and actions in major trauma centers were a critical factor in this response. The objective of this investigation was to describe and characterize organizational dynamics and leadership themes immediately after the bombings by utilizing a novel structured sequential qualitative approach consisting of a focus group followed by subsequent detailed interviews and combined expert analysis. Across physician leaders representing 7 hospitals, several leadership and management themes emerged from our analysis: communications and volunteer surges, flexibility, the challenge of technology, and command versus collaboration. Disasters provide a distinctive context in which to study the robustness and resilience of response systems. Therefore, in the aftermath of a large-scale crisis, every effort should be invested in forming a coalition and collecting critical lessons so they can be shared and incorporated into best practices and preparations. Novel communication strategies, flexible leadership structures, and improved information systems will be necessary to reduce morbidity and mortality during future events.

  13. In Brief: Geoengineering draft statement

    Science.gov (United States)

    Showstack, Randy

    2009-04-01

    The American Meteorological Society (AMS) has prepared a draft policy statement on geoengineering the climate system, which the AMS Council is considering for approval. The statement notes, “Geoengineering will not substitute for either aggressive mitigation or proactive adaptation. It could contribute to a comprehensive risk management strategy to slow climate change and alleviate its negative impacts, but the potential for adverse and unintended consequences implies a need for adequate research, appropriate regulation, and transparent consideration.” The statement, if adopted, indicates that AMS recommends enhanced research on the scientific and technological potential for geoengineering the climate system; additional study of the historical, ethical, legal, political, and societal aspects of the geoengineering issues; and the development and analysis of policy options to promote transparency and international cooperation in exploring geoengineering options along with restrictions on reckless efforts to manipulate the climate system. AMS is accepting comments on the draft statement until 23 April. For more information, visit http://ametsoc.org/policy/draftstatements/index.html#draft.

  14. Antithrombotic and fibrinolytic drugs for retinal vein occlusion: a systematic review and a call for action.

    Science.gov (United States)

    Squizzato, A; Manfredi, E; Bozzato, S; Dentali, F; Ageno, W

    2010-02-01

    Optimal management of retinal vein occlusion (RVO) is still a matter of debate. Antithrombotic and fibrinolytic drugs have been investigated after demonstration of a role of thrombosis in the complex pathogenesis of the disease. Aim of our study was to systematically summarise best available evidence on the acute treatment and on the secondary prevention of RVO with antithrombotic and fibrinolytic drugs. A computer-assisted search of the MEDLINE and EMBASE electronic databases up to January 2009 was performed. Two review authors selected all published randomised controlled trials (RCTs) from the search, assessed study quality and extracted data. Based on Jadad's score, RCTs were stratified into three quality categories. A total of six RCTs were included. Only one RCT of high quality was identified. A total of 384 patients were investigated, 234 with central retinal vein occlusion and 150 with branch retinal vein occlusion. No study enrolled more than 100 patients. Three studies compared therapeutic doses of low-molecular-weight heparin (LMWH) with low-dose aspirin, one study compared ticlopidine with placebo and two studies compared intravenous fibrinolytic therapy followed by warfarin or aspirin with either haemodilution or no treatment. A partial improvement of visual acuity was reported in every study, independently of the study drug. No long-term secondary prevention study was published. The present systematic review suggests that antithrombotic therapy, in particular LMWH, may be part of the therapeutic armamentarium for patients with recent onset RVO. No firm recommendation can be provided given the limited available evidence.

  15. Ginger-Mechanism of action in chemotherapy-induced nausea and vomiting: A review.

    Science.gov (United States)

    Marx, Wolfgang; Ried, Karin; McCarthy, Alexandra L; Vitetta, Luis; Sali, Avni; McKavanagh, Daniel; Isenring, Liz

    2017-01-02

    Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT3, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.

  16. Health initiatives to target obesity in surface transport industries: Review and implications for action

    Directory of Open Access Journals (Sweden)

    Anjum Naweed

    2015-06-01

    Full Text Available Lifestyle-related chronic diseases pose a considerable burden to the individual and the wider society, with correspondingly negative effects on industry. Obesity is a particular problem for the Australasian road and rail industries where it is associated with specific cardiac and fatigue-related safety risks, and levels are higher than those found in the general population. Despite this recognition, and the introduction of National Standards, very little consensus exists regarding approaches to preventative health for surface transport workers. A review of evidence regarding effective health promotion initiatives is urgently needed to inform best practice in this cohort. This review draws together research informing the scope and effectiveness of health promotion programs, initiatives and interventions targeting overweight and obesity in safety critical surface transport domains including the truck, bus and rail industries. A number of health interventions demonstrated measurable successes, including incentivising, peer mentoring, verbal counselling, development of personalised health profiles, and offer of healthier on-site food choices – some of which also resulted in sizeable return on investment over the long term.

  17. 76 FR 59155 - Notice of Availability of South Coast Draft Resource Management Plan Revision and Draft...

    Science.gov (United States)

    2011-09-23

    ... Bureau of Land Management Notice of Availability of South Coast Draft Resource Management Plan Revision... (BLM) has prepared a Draft Resource Management Plan (RMP) and Draft Environmental Impact Statement (EIS... demands on the resources of the public lands; changing policies and emphasis on the management of public...

  18. 77 FR 74508 - Notice of Availability of the Draft Resource Management Plan Amendment, Draft Environmental...

    Science.gov (United States)

    2012-12-14

    ... Bureau of Land Management Notice of Availability of the Draft Resource Management Plan Amendment, Draft Environmental Impact Statement for the Ring of Fire Resource Management Plan--Haines Planning Area, Alaska... Management Act of 1976, as amended, the Bureau of Land Management (BLM) has prepared a Draft Resource...

  19. A systematic review of the serotonergic effects of mirtazapine in humans: implications for its dual action status.

    Science.gov (United States)

    Gillman, P Ken

    2006-03-01

    A systematic review of published work concerning mirtazapine was undertaken to assess possible evidence of serotonergic effects or serotonin toxicity (ST) in humans, because drug toxicity and interaction data from human over-doses is an useful source of information about the nature and potency of drug effects. There is a paucity of evidence for mirtazapine having effects on any indicator of serotonin elevation, which leads to an emphasis on ST as an important line of evidence. Mirtazapine is compared with its analogue mianserin, and other serotonergic drugs. Although mirtazapine is referred to as a dual-action 'noradrenergic and specific serotonergic drug' (NaSSA) little evidence to support that idea exists, except from initial microdialysis studies in animals showing small effects; those have not subsequently been replicated or substantiated by independent researchers. Also, new data indicate its affinity for Alpha 2 adrenoceptors is not different to mianserin. It appears to exhibit no serotonergic symptoms or toxicity in over-dose by itself, nor is there evidence that it precipitates ST in combination with monoamine oxidase inhibitors, as would be expected if it raises intra-synaptic serotonin levels. Mirtazapine has no demonstrable serotonergic effects in humans and there is insufficient evidence to designate it as a dual-action drug.

  20. The Relationship Between the Mechanisms of Action and Safety Profiles of Intrathecal Morphine and Ziconotide: A Review of the Literature.

    Science.gov (United States)

    Webster, Lynn R

    2015-07-01

    To better characterize safety profiles associated with the intrathecal (IT) administration of morphine and ziconotide and discuss how they relate to mechanisms of action. Published data were evaluated to identify potential relationships between safety profiles of IT morphine and IT ziconotide and their mechanisms of action. Potentially severe and clinically relevant adverse events (AEs) associated with IT morphine include respiratory depression, tolerance, and granuloma formulation, whereas IT ziconotide is associated with neuropsychiatric AEs, such as cognitive impairment, hallucinations, and changes in mood or consciousness, particularly with high doses and rapid titration. AEs associated with these IT therapies may result from spread of the medication out of the IT space into areas of the central and peripheral nervous systems and systemic circulation. AEs that occur usually can be managed and, in some cases, prevented. To mitigate risk, patients' histories should be reviewed to identify potential complicating factors (e.g., obesity or other risk factors for respiratory dysfunction in patients receiving IT morphine; a history of psychosis in patients receiving IT ziconotide). Also, treatment should be initiated at a low dose, titrated slowly, and patients should be closely monitored during treatment. IT morphine and IT ziconotide are approved by the US Food and Drug Administration for patients who do not respond to less invasive treatments, but the safety profiles of each may make them more or less appropriate for certain patient populations. Wiley Periodicals, Inc.

  1. 75 FR 8046 - National Environmental Policy Act (NEPA) Draft Guidance, “Consideration of the Effects of Climate...

    Science.gov (United States)

    2010-02-23

    ... greenhouse gas emissions and climate change when they describe the environmental impacts of a proposed action... QUALITY National Environmental Policy Act (NEPA) Draft Guidance, ``Consideration of the Effects of Climate Change and Greenhouse Gas Emissions.'' AGENCY: Council On Environmental Quality. ACTION: Notice of...

  2. From Kothari Commission Report to Some Inputs for Draft National Education Policy 2016: An Attempt at Contextualizing Current Education Policymaking

    Science.gov (United States)

    Tharakan, P. K. Michael

    2017-01-01

    The Subramanian Committee Report 2016 and the Some Inputs for Draft National Education Policy 2016 (SIDNEP 2016) are compared with its predecessors, the Kothari Commission Report 1964-1966 and the National Education Policy 1986 along with its Programme for Action 1986 and the revised Programme for Action 1992, to see how well its proposals are…

  3. Parents’ actions, challenges, and needs while enabling participation of children with a physical disability: a scoping review

    Directory of Open Access Journals (Sweden)

    Piškur Barbara

    2012-11-01

    Full Text Available Abstract Background Pediatric rehabilitation considers Family-centered service (FCS as a way to increase participation of children with a physical disability in daily life. An important principal is that parents greatly contribute to their child’s participation at school, at home, and in the community. However, it is unclear what kind of information is available from literature about what parents actually do to support their child’s participation and what problems and needs they experience? Hence, the aim of this study was to provide an overview of the actions, challenges, and needs of parents in enabling participation of their child with a physical disability that is neurological and non-progressive in nature. Methods Scoping review with extensive literature search (September 2011 and a thematic analysis to synthesize findings. Results Fourteen relevant articles revealed two major themes: ‘parents enable and support performance of meaningful activities’ and ‘parents enable, change and use the environment’. Each theme holds a number of actions (e.g. choosing the right type of meaningful activities for facilitating social contacts and challenges (e.g. negative attitudes of other people. Less information is available about the needs of parents. Conclusions This study indicates that parents apply a broad range of strategies to support participation of their children. They experience many challenges, especially as a result of constraints in the social and physical environments. However, this review also shows that little is known about needs of parents in facilitating participation. As Family-centered service (FCS philosophy is all about the needs of the child and the family, it is essential to further investigate the needs of the parents and to understand if and to what extent they wish to be supported in enabling their child’s participation in daily life.

  4. New research findings since the 2007 Surgeon General's Call to Action to Prevent and Reduce Underage Drinking: a review.

    Science.gov (United States)

    Hingson, Ralph; White, Aaron

    2014-01-01

    In 2007, the U.S. Department of Health and Human Services issued The Surgeon General's Call to Action to Prevent and Reduce Underage Drinking, a publication documenting a problem linked to nearly 5,000 injury deaths annually and poor academic performance, potential cognitive deficits, risky sexual behavior, physical and sexual assaults, and other substance use. This report reviews subsequent underage drinking and related traffic fatality trends and research on determinants, consequences, and prevention interventions. New research reports, meta-analyses, and systematic literature reviews were examined. Since the Call to Action, reductions in underage frequency of drinking, heavy drinking occasions, and alcohol-related traffic deaths that began in the 1980s when the drinking age nationally became 21 have continued. Knowledge regarding determinants and consequences, particularly the effects of early-onset drinking, parental alcohol provision, and cognitive effects, has expanded. Additional studies support associations between the legal drinking age of 21, zero tolerance laws, higher alcohol prices, and reduced drinking and related problems. New research suggests that use/lose laws, social host liability, internal possession laws, graduated licensing, and night driving restrictions reduce traffic deaths involving underage drinking drivers. Additional studies support the positive effects of individually oriented interventions, especially screening and brief motivational interventions, web and face-to-face social norms interventions, college web-based interventions, parental interventions, and multicomponent community interventions. Despite reductions in underage alcohol consumption and related traffic deaths, underage drinking remains an enduring problem. Continued research is warranted in minimally studied areas, such as prospective studies of alcohol and brain development, policy studies of use/lose laws, internal possession laws, social host liability, and parent

  5. 75 FR 52357 - Request for Comment: National Center for Complementary and Alternative Medicine Draft Strategic Plan

    Science.gov (United States)

    2010-08-25

    ... for Comment: National Center for Complementary and Alternative Medicine Draft Strategic Plan ACTION: Notice. SUMMARY: The National Center for Complementary and Alternative Medicine (NCCAM) is developing its... Center for Complementary and Alternative Medicine (NCCAM) was established in 1998 with the mission of...

  6. 76 FR 5566 - Notice of Availability for the Draft Programmatic Environmental Assessment for the Development...

    Science.gov (United States)

    2011-02-01

    ... renewable energy. The purpose of the proposed action is to reduce dependency on fossil fuels and increase...-scale wind energy projects at USMC CONUS facilities. Environmental resources addressed in the Draft PEA include land use; noise; geological resources; water resources; biological resources; cultural resources...

  7. 76 FR 30754 - Notice of Availability of the Draft Environmental Impact Statement: Riverside and Orange Counties...

    Science.gov (United States)

    2011-05-26

    ...: Riverside and Orange Counties, CA AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of... the Draft Environmental Impact Statement for a proposed highway project in Riverside and Orange... in Riverside and Orange Counties. The State Route 91 Corridor Improvement Project proposes to widen...

  8. 78 FR 68460 - Draft Guidance for Industry on Frequently Asked Questions About Medical Foods; Second Edition...

    Science.gov (United States)

    2013-11-14

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Frequently Asked Questions About Medical Foods; Second Edition; Reopening of the Comment Period AGENCY: Food and Drug Administration, HHS. ACTION: Notice; reopening of the comment period. SUMMARY: The Food and Drug Administration...

  9. 78 FR 74154 - Draft Guidance for Industry on Recommendations for Preparation and Submission of Animal Food...

    Science.gov (United States)

    2013-12-10

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Recommendations for Preparation and Submission of Animal Food Additive Petitions; Reopening of the Comment Period AGENCY: Food and Drug Administration, HHS. ACTION: Notice; reopening of the comment period. SUMMARY: The Food and Drug...

  10. 76 FR 68499 - Draft WaterSMART Cooperative Watershed Management Program Funding Opportunity Announcement

    Science.gov (United States)

    2011-11-04

    ... and time. Water shortage and water-use conflicts have become more commonplace in many areas of the... Office of the Secretary Draft WaterSMART Cooperative Watershed Management Program Funding Opportunity Announcement AGENCY: Office of the Assistant Secretary for Water and Science, Interior. ACTION: Notice of...

  11. 77 FR 20030 - Draft Guidance for Industry: Reporting Harmful and Potentially Harmful Constituents in Tobacco...

    Science.gov (United States)

    2012-04-03

    ... Cosmetic Act; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled... applicable in the smoke of each tobacco product.'' Reports must be by the brand and by quantity in each brand...

  12. 75 FR 28012 - Pesticides; Draft Guidance for Pesticide Registrants on False or Misleading Pesticide Product...

    Science.gov (United States)

    2010-05-19

    ... Brand Names AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of availability. SUMMARY: The Agency is announcing the availability of and seeking public comment on a draft Pesticide Registration Notice (PR Notice) entitled ``False or Misleading Pesticide Product Brand Names.'' PR Notices are issued...

  13. 75 FR 34448 - Pesticides; Draft Guidance for Pesticide Registrants on False or Misleading Pesticide Product...

    Science.gov (United States)

    2010-06-17

    ... Brand Names; Extension of Comment Period AGENCY: Environmental Protection Agency (EPA). ACTION: Notice..., announcing the availability of and seeking public comment on a draft Pesticide Registration Notice (PR Notice) entitled ``False or Misleading Pesticide Product Brand Names.'' This document extends the comment period...

  14. 76 FR 61366 - Food and Drug Administration Transparency Initiative: Draft Proposals for Public Comment to...

    Science.gov (United States)

    2011-10-04

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Transparency Initiative: Draft Proposals for Public Comment to Increase Transparency By Promoting Greater Access to the Agency's Compliance and Enforcement Data; Availability AGENCY: Food and Drug Administration, HHS. ] ACTION: Notice of...

  15. 75 FR 67149 - Request for Public Comment on the Draft 2010 National Nanotechnology Initiative Strategic Plan

    Science.gov (United States)

    2010-11-01

    ... TECHNOLOGY POLICY Request for Public Comment on the Draft 2010 National Nanotechnology Initiative Strategic Plan AGENCY: White House Office of Science and Technology Policy. ACTION: Notice: request for public comment. SUMMARY: With this notice, the White House Office of Science and Technology Policy and the...

  16. 76 FR 2428 - Request for Public Comment on the Draft National Nanotechnology Initiative Strategy for...

    Science.gov (United States)

    2011-01-13

    ... TECHNOLOGY POLICY Request for Public Comment on the Draft National Nanotechnology Initiative Strategy for... Technology Policy. ACTION: Notice: Request for public comment. SUMMARY: With this notice, the White House Office of Science and Technology Policy and the Nanoscale Science, Engineering, and Technology...

  17. 75 FR 75707 - Request for Public Comment on the Draft National Nanotechnology Initiative Strategy for...

    Science.gov (United States)

    2010-12-06

    ... TECHNOLOGY POLICY Request for Public Comment on the Draft National Nanotechnology Initiative Strategy for... Technology Policy. ACTION: Notice: Request for Public Comment. SUMMARY: With this notice, the White House Office of Science and Technology Policy and the Nanoscale Science, Engineering, and Technology...

  18. 78 FR 26662 - Draft Supplement to the Generic Environmental Impact Statement for License Renewal of Nuclear...

    Science.gov (United States)

    2013-05-07

    ... COMMISSION Draft Supplement to the Generic Environmental Impact Statement for License Renewal of Nuclear Plants; NextEra Energy Seabrook; Seabrook Station, Unit 1 AGENCY: Nuclear Regulatory Commission. ACTION... Supplement 46 to the Generic Environmental Impact Statement for License Renewal of Nuclear Plants (GEIS...

  19. 76 FR 34999 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Science.gov (United States)

    2011-06-15

    ... Methicillin-Resistant Staphylococcus Aureus for Culture-Based Devices; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration...

  20. 76 FR 55923 - Draft Guidance for Industry: Submission of Warning Plans for Cigarettes and Smokeless Tobacco...

    Science.gov (United States)

    2011-09-09

    ... Education Act, as amended by the Family Smoking Prevention and Tobacco Control Act; and under the Federal... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Submission of Warning Plans for... Collection; Comment Request AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...

  1. 78 FR 21128 - Molecular Diagnostic Instruments With Combined Functions; Draft Guidance for Industry and Food...

    Science.gov (United States)

    2013-04-09

    ... HUMAN SERVICES Food and Drug Administration Molecular Diagnostic Instruments With Combined Functions; Draft Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the...

  2. 77 FR 74195 - Draft Guidance for Industry and Food and Drug Administration Staff; Design Considerations for...

    Science.gov (United States)

    2012-12-13

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Design Considerations for Devices Intended for Home Use; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the...

  3. 77 FR 125 - Draft Guidance for Industry and Food and Drug Administration Staff; Medical Device Classification...

    Science.gov (United States)

    2012-01-03

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Medical Device Classification Product Codes; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. ] SUMMARY: The Food and Drug Administration (FDA) is announcing the availability...

  4. 75 FR 44267 - Draft Guidance for Industry and Food and Drug Administration Staff; Medical Devices; Neurological...

    Science.gov (United States)

    2010-07-28

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Comment Period AGENCY: Food and Drug Administration, HHS. ACTION: Notice; reopening of comment period. SUMMARY: The Food and Drug Administration (FDA) is reopening until September 7, 2010, the comment period...

  5. 78 FR 41069 - Medical Device Reporting for Manufacturers; Draft Guidance for Industry and Food and Drug...

    Science.gov (United States)

    2013-07-09

    ... HUMAN SERVICES Food and Drug Administration Medical Device Reporting for Manufacturers; Draft Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of...

  6. 77 FR 56817 - Notice of Public Hearings for the Draft Environmental Impact Statement for Medical Facilities...

    Science.gov (United States)

    2012-09-14

    ... USU to serve as the core academic health research center at WRNMMC. The University Expansion would... status as a World Class Academic Health Center. The Draft EIS considers the No Action Alternative and two... health research center at WRNMMC. The University Expansion is needed because current operations are...

  7. 77 FR 14401 - Draft Guidance on Drug Safety Information-FDA's Communication to the Public; Availability

    Science.gov (United States)

    2012-03-09

    ... Communication to the Public; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... ``Drug Safety Information-- FDA's Communication to the Public.'' This draft guidance updates and revises the March 2007 guidance entitled ``Drug Safety Information-- FDA's Communication to the Public.'' This...

  8. 78 FR 32668 - Draft Guidance for Industry: Changes to an Approved Application: Biological Products: Human Blood...

    Science.gov (United States)

    2013-05-31

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Changes to an Approved... Manufacture; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and... Industry: Changes to an Approved Application: Biological Products: Human Blood and Blood Components...

  9. 76 FR 4719 - Draft Comprehensive Conservation Plan and Environmental Assessment, Selawik National Wildlife...

    Science.gov (United States)

    2011-01-26

    ... commercial guides and transporters to maintain big game hunting opportunities while reducing social conflict... Fish and Wildlife Service Draft Comprehensive Conservation Plan and Environmental Assessment, Selawik National Wildlife Refuge, Kotzebue, AK AGENCY: U.S. Fish and Wildlife Service, Interior. ACTION: Notice to...

  10. 78 FR 28732 - Revisions to Electric Quarterly Report Filing Process; Availability of Draft XML Schema

    Science.gov (United States)

    2013-05-16

    ...; Availability of Draft XML Schema AGENCY: Federal Energy Regulatory Commission, DOE. ACTION: Notification of...://www.ferc.gov ), Extensible Mark-Up Language (XML) needed to make Electric Quarterly Report (EQR.... DATES: The XML is now available at the links mentioned below. FOR FURTHER INFORMATION CONTACT: Christina...

  11. 75 FR 4794 - Draft Revised Strategic Plan for FY 2010-2015

    Science.gov (United States)

    2010-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEFENSE NUCLEAR FACILITIES SAFETY BOARD Draft Revised Strategic Plan for FY 2010-2015 AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice. SUMMARY: In accordance with OMB Circular No. A-11, the Defense Nuclear Facilities...

  12. 78 FR 35959 - Notice of Availability of Draft Resource Management Plan and Associated Environmental Impact...

    Science.gov (United States)

    2013-06-14

    ..., management alternatives, or other ideas to help in determining future land use decisions for the planning... selected. All alternatives propose to maintain the Fort Meade and Fossil Cycad ACECs. Under alternatives B... management alternatives. The draft RMP/EIS includes a range of management actions within four management...

  13. 78 FR 17708 - Endangered and Threatened Wildlife and Plants; Draft Revised Supplement to the Grizzly Bear...

    Science.gov (United States)

    2013-03-22

    ... the Grizzly Bear Recovery Plan AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of document... availability of a draft Revised Supplement to the Grizzly Bear Recovery Plan. Specifically, this supplement..., Grizzly bears (Ursus arctos horribilis) are federally listed as threatened under the Endangered Species...

  14. 76 FR 55703 - Draft Environmental Impact Statement/Environmental Impact Report and Notice of Public Meetings...

    Science.gov (United States)

    2011-09-08

    ... preliminary design concepts being considered in the Draft EIS/EIR are one three-story building or two two... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR... of Reclamation, Interior. ACTION: Notice of availability and public meetings. SUMMARY: The Bureau of...

  15. 76 FR 16634 - Seal Beach National Wildlife Refuge, Orange County, CA; Draft Comprehensive Conservation Plan...

    Science.gov (United States)

    2011-03-24

    ... observation and photography, environmental education and interpretation. We initiated the CCP/EA for the Seal... Conservation Plan/Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of... availability of a draft comprehensive conservation plan (CCP) and environmental assessment (EA) for the Seal...

  16. 77 FR 24722 - Draft Guidance for Industry: Safety of Nanomaterials in Cosmetic Products; Availability

    Science.gov (United States)

    2012-04-25

    ... Cosmetic Products; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The... ``Guidance for Industry: Safety of Nanomaterials in Cosmetic Products.'' The draft guidance, when finalized, will represent FDA's current thinking on the safety assessment of nanomaterials in cosmetic products...

  17. 78 FR 78367 - Draft Prescription Drug User Fee Act V Information Technology Plan; Availability for Comment

    Science.gov (United States)

    2013-12-26

    ... affecting drug and biologics approvals, drug supply chain, and other topics related to human pharmaceuticals... HUMAN SERVICES Food and Drug Administration Draft Prescription Drug User Fee Act V Information Technology Plan; Availability for Comment AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY...

  18. 75 FR 43528 - Seeking Public Comment on Draft National Health Security Strategy Biennial Implementation Plan

    Science.gov (United States)

    2010-07-26

    ... HUMAN SERVICES Office of the Secretary Seeking Public Comment on Draft National Health Security Strategy.... ACTION: Notice. Authority: Public Health Service Act, 42 U.S.C. 300hh-1. SUMMARY: To help the Nation achieve national health security and to implement the first quadrennial National Health Security Strategy...

  19. 75 FR 62433 - Notice of Public Hearings and the Availability of a Draft Programmatic Environmental Impact...

    Science.gov (United States)

    2010-10-08

    ... a Draft Programmatic Environmental Impact Statement/Overseas Environmental Impact Statement (PEIS... agencies. The purpose of the Proposed Action is to fund the investigation of the geology and geophysics of...: Currently, individual Environmental Assessments (EAs) are prepared for individual or small numbers of...

  20. 77 FR 22761 - Draft Management Plan and Environmental Assessment for Monitor National Marine Sanctuary: Notice...

    Science.gov (United States)

    2012-04-17

    ... battle with the Confederate ironclad, CSS Virginia in Hampton Roads, VA., on March 9, 1862. The sanctuary... federal agencies, and other stakeholders. The draft plan is comprised of eight action plans (education and... 30, 6:30 p.m., Raleigh, NC, NC Museum of History, 5 East Edenton Street, Raleigh, NC 27601. 2. May 1...

  1. 78 FR 64970 - New Deadlines for Public Comment on Draft Environmental Documents

    Science.gov (United States)

    2013-10-30

    ..., Solano 23732.pdf. County, California. Big Muddy National Fish and 78 FR 60306; October 1, 2013 November... Fish and Wildlife Service New Deadlines for Public Comment on Draft Environmental Documents AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice. SUMMARY: We announce new deadlines for the public...

  2. 77 FR 30319 - Draft Environmental Impact Statement for General Management Plan, Fort Pulaski National Monument, GA

    Science.gov (United States)

    2012-05-22

    ... National Monument, GA AGENCY: National Park Service, Interior. ACTION: Notice of Availability of the Draft...) and Wilderness Study for Fort Pulaski National Monument (monument). Consistent with NPS laws... http://parkplanning.nps.gov/FOPU . To request a copy, contact Fort Pulaski National Monument...

  3. 78 FR 4417 - Draft Guidance for Industry and Food and Drug Administration Staff; Submissions for Postapproval...

    Science.gov (United States)

    2013-01-22

    ... Marketing Applications; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The... Under a BLA, NDA, or PMA.'' This draft guidance intends to provide the underlying principles to determine the type of marketing submission that may be required for postapproval changes to a combination...

  4. 77 FR 76049 - Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Correction

    Science.gov (United States)

    2012-12-26

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Correction AGENCY: Food and Drug Administration, HHS. ACTION: Notice; correction. ] SUMMARY: The Food and Drug Administration (FDA) is correcting a notice that appeared in the Federal...

  5. 76 FR 6685 - Draft Guidance for Industry and Food and Drug Administration Staff; Recommended Warning for...

    Science.gov (United States)

    2011-02-07

    ... as a cause of respiratory allergic reactions; (2) rhinitis, conjunctivitis, and dyspnea; (3... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration...; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug...

  6. Central actions of glucocorticoids in the control of body fluid homeostasis: Review

    Directory of Open Access Journals (Sweden)

    S.G. Ruginsk

    2009-01-01

    Full Text Available The involvement of the hypothalamic-pituitary-adrenal axis in the control of body fluid homeostasis has been extensively investigated in the past few years. In the present study, we reviewed the recent results obtained using different approaches to investigate the effects of glucocorticoids on the mechanisms of oxytocin and vasopressin synthesis and secretion in response to acute and chronic plasma volume and osmolality changes. The data presented here suggest that glucocorticoids are not only involved in the mechanisms underlying the fast release but also in the transcriptional events that lead to decreased synthesis and secretion of these neuropeptides, particularly oxytocin, under diverse experimental conditions of altered fluid volume and tonicity. The endocannabinoid system, through its effects on glutamatergic neurotransmission within the hypothalamus and the nuclear factor κB-mediated transcriptional activity, seems to be also involved in the specific mechanisms by which glucocorticoids exert their central effects on neurohypophyseal hormone synthesis and secretion.

  7. Bioactivity, mechanism of action, and cytotoxicity of copper-based nanoparticles: a review.

    Science.gov (United States)

    Ingle, Avinash P; Duran, Nelson; Rai, Mahendra

    2014-02-01

    Nanotechnology is an emerging branch of science, which has potential to solve many problems in different fields. The union of nanotechnology with other fields of sciences including physics, chemistry, and biology has brought the concept of synthesis of nanoparticles from their respective metals. Till date, many types of nanoparticles have been synthesized and being used in different fields for various applications. Moreover, copper nanoparticles attract biologists because of their significant and broad-spectrum bioactivity. Due to the large surface area to volume ratio, copper nanoparticles have been used as potential antimicrobial agent in many biomedical applications. But the excess use of any metal nanoparticles increase the chance of toxicity to humans, other living beings, and environment. In this article, we have critically reviewed the bioactivities and cytotoxicity of copper nanoparticles. We have also focused on possible mechanism involved in its interaction with microbes.

  8. Using Social Media for Actionable Disease Surveillance and Outbreak Management: A Systematic Literature Review.

    Directory of Open Access Journals (Sweden)

    Lauren E Charles-Smith

    Full Text Available Research studies show that social media may be valuable tools in the disease surveillance toolkit used for improving public health professionals' ability to detect disease outbreaks faster than traditional methods and to enhance outbreak response. A social media work group, consisting of surveillance practitioners, academic researchers, and other subject matter experts convened by the International Society for Disease Surveillance, conducted a systematic primary literature review using the PRISMA framework to identify research, published through February 2013, answering either of the following questions: Can social media be integrated into disease surveillance practice and outbreak management to support and improve public health?Can social media be used to effectively target populations, specifically vulnerable populations, to test an intervention and interact with a community to improve health outcomes?Examples of social media included are Facebook, MySpace, microblogs (e.g., Twitter, blogs, and discussion forums. For Question 1, 33 manuscripts were identified, starting in 2009 with topics on Influenza-like Illnesses (n = 15, Infectious Diseases (n = 6, Non-infectious Diseases (n = 4, Medication and Vaccines (n = 3, and Other (n = 5. For Question 2, 32 manuscripts were identified, the first in 2000 with topics on Health Risk Behaviors (n = 10, Infectious Diseases (n = 3, Non-infectious Diseases (n = 9, and Other (n = 10.The literature on the use of social media to support public health practice has identified many gaps and biases in current knowledge. Despite the potential for success identified in exploratory studies, there are limited studies on interventions and little use of social media in practice. However, information gleaned from the articles demonstrates the effectiveness of social media in supporting and improving public health and in identifying target populations for intervention. A primary recommendation resulting from the review

  9. Cancer Survivors in the United States: A Review of the Literature and a Call to Action

    Science.gov (United States)

    Valdivieso, Manuel; Kujawa, Ann M.; Jones, Tisha; Baker, Laurence H.

    2012-01-01

    Background: The number of cancer survivors in the U.S. has increased from 3 million in 1971, when the National Cancer Act was enacted, to over 12 million today. Over 70% of children affected by cancer survive more than 10 years, and most are cured. Most cancer survivors are adults, with two-thirds of them 65 years of age or older and two-thirds alive at five years. The most common cancer diagnoses among survivors include breast, prostate and colorectal cancers. This review was conducted to better appreciate the challenges associated with cancer survivors and the opportunities healthcare providers have in making a difference for these patients. Methods: Comprehensive review of literature based on PubMed searches on topics related to cancer survivorship, and associated physical, cognitive, socio-economic, sexual/behavioral and legal issues. Results: At least 50% of cancer survivors suffer from late treatment-related side effects, often including physical, psychosocial, cognitive and sexual abnormalities, as well as concerns regarding recurrence and/or the development of new malignancies. Many are chronic in nature and some are severe and even life-threatening. Survivors also face issues involving lack of appropriate health maintenance counseling, increased unemployment rate and workplace discrimination. Conclusions: Advances in the diagnosis and treatment of cancer will lead to more survivors and better quality of life. However, tools to recognize potentially serious long-lasting side effects of cancer therapy earlier in order to treat and/or prevent them must be developed. It is incumbent upon our health care delivery systems to make meeting these patients' needs a priority. PMID:22275855

  10. Cancer survivors in the United States: a review of the literature and a call to action.

    Science.gov (United States)

    Valdivieso, Manuel; Kujawa, Ann M; Jones, Tisha; Baker, Laurence H

    2012-01-01

    The number of cancer survivors in the U.S. has increased from 3 million in 1971, when the National Cancer Act was enacted, to over 12 million today. Over 70% of children affected by cancer survive more than 10 years, and most are cured. Most cancer survivors are adults, with two-thirds of them 65 years of age or older and two-thirds alive at five years. The most common cancer diagnoses among survivors include breast, prostate and colorectal cancers. This review was conducted to better appreciate the challenges associated with cancer survivors and the opportunities healthcare providers have in making a difference for these patients. Comprehensive review of literature based on PubMed searches on topics related to cancer survivorship, and associated physical, cognitive, socio-economic, sexual/behavioral and legal issues. At least 50% of cancer survivors suffer from late treatment-related side effects, often including physical, psychosocial, cognitive and sexual abnormalities, as well as concerns regarding recurrence and/or the development of new malignancies. Many are chronic in nature and some are severe and even life-threatening. Survivors also face issues involving lack of appropriate health maintenance counseling, increased unemployment rate and workplace discrimination. Advances in the diagnosis and treatment of cancer will lead to more survivors and better quality of life. However, tools to recognize potentially serious long-lasting side effects of cancer therapy earlier in order to treat and/or prevent them must be developed. It is incumbent upon our health care delivery systems to make meeting these patients' needs a priority.

  11. Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 - 2013).

    Science.gov (United States)

    Carta, Fabrizio; Supuran, Claudiu T

    2013-01-01

    The benzothiadiazines and high ceiling diuretics (hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide) contain primary sulfamoyl moieties acting as zinc-binding groups in the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). These drugs are widely used clinically and were recently shown to weakly inhibit isoforms CA I and II, but to possess stronger activity against isoforms involved in other important pathologies, for example, obesity, cancer, epilepsy and hypertension. The class of clinically used diuretics, with CA inhibitory properties, is the main topic of the review. A patent literature review covering the period from 2005 to 2013 is presented. This section presents an overview of the patent literature in the sulfonamide diuretic field. Most of the patents deal with the combination of diuretic sulfonamide CA inhibitors with other agents useful in the management of cardiovascular diseases and obesity. Such combinations exert a better therapeutic activity compared to similar diuretics that do not inhibit CAs, raising the question of the polypharmacological and drug repositioning effects of these old drugs. These effects seem to be due to the potent inhibition of such drugs against CA isoforms present in kidneys and blood vessels, which explain both the blood pressure lowering effects as well as organ-protective activity of the drugs. An explanation of these data is provided by the fact that inhibition of the renal CAs leads to a large increase of the nitrite excretion in urine, suggesting that renal CAs are involved in nitrite reabsorption in humans. Important lessons for the drug design of sulfonamide CA inhibitors (CAIs) can be drawn from these data.

  12. Using Social Media for Actionable Disease Surveillance and Outbreak Management: A Systematic Literature Review

    Science.gov (United States)

    Charles-Smith, Lauren E.; Reynolds, Tera L.; Cameron, Mark A.; Conway, Mike; Lau, Eric H. Y.; Olsen, Jennifer M.; Pavlin, Julie A.; Shigematsu, Mika; Streichert, Laura C.; Suda, Katie J.; Corley, Courtney D.

    2015-01-01

    Objective Research studies show that social media may be valuable tools in the disease surveillance toolkit used for improving public health professionals’ ability to detect disease outbreaks faster than traditional methods and to enhance outbreak response. A social media work group, consisting of surveillance practitioners, academic researchers, and other subject matter experts convened by the International Society for Disease Surveillance, conducted a systematic primary literature review using the PRISMA framework to identify research, published through February 2013, answering either of the following questions: Can social media be integrated into disease surveillance practice and outbreak management to support and improve public health? Can social media be used to effectively target populations, specifically vulnerable populations, to test an intervention and interact with a community to improve health outcomes? Examples of social media included are Facebook, MySpace, microblogs (e.g., Twitter), blogs, and discussion forums. For Question 1, 33 manuscripts were identified, starting in 2009 with topics on Influenza-like Illnesses (n = 15), Infectious Diseases (n = 6), Non-infectious Diseases (n = 4), Medication and Vaccines (n = 3), and Other (n = 5). For Question 2, 32 manuscripts were identified, the first in 2000 with topics on Health Risk Behaviors (n = 10), Infectious Diseases (n = 3), Non-infectious Diseases (n = 9), and Other (n = 10). Conclusions The literature on the use of social media to support public health practice has identified many gaps and biases in current knowledge. Despite the potential for success identified in exploratory studies, there are limited studies on interventions and little use of social media in practice. However, information gleaned from the articles demonstrates the effectiveness of social media in supporting and improving public health and in identifying target populations for intervention. A primary recommendation resulting

  13. Using Social Media for Actionable Disease Surveillance and Outbreak Management: A Systematic Literature Review.

    Science.gov (United States)

    Charles-Smith, Lauren E; Reynolds, Tera L; Cameron, Mark A; Conway, Mike; Lau, Eric H Y; Olsen, Jennifer M; Pavlin, Julie A; Shigematsu, Mika; Streichert, Laura C; Suda, Katie J; Corley, Courtney D

    2015-01-01

    Research studies show that social media may be valuable tools in the disease surveillance toolkit used for improving public health professionals' ability to detect disease outbreaks faster than traditional methods and to enhance outbreak response. A social media work group, consisting of surveillance practitioners, academic researchers, and other subject matter experts convened by the International Society for Disease Surveillance, conducted a systematic primary literature review using the PRISMA framework to identify research, published through February 2013, answering either of the following questions: Can social media be integrated into disease surveillance practice and outbreak management to support and improve public health?Can social media be used to effectively target populations, specifically vulnerable populations, to test an intervention and interact with a community to improve health outcomes?Examples of social media included are Facebook, MySpace, microblogs (e.g., Twitter), blogs, and discussion forums. For Question 1, 33 manuscripts were identified, starting in 2009 with topics on Influenza-like Illnesses (n = 15), Infectious Diseases (n = 6), Non-infectious Diseases (n = 4), Medication and Vaccines (n = 3), and Other (n = 5). For Question 2, 32 manuscripts were identified, the first in 2000 with topics on Health Risk Behaviors (n = 10), Infectious Diseases (n = 3), Non-infectious Diseases (n = 9), and Other (n = 10). The literature on the use of social media to support public health practice has identified many gaps and biases in current knowledge. Despite the potential for success identified in exploratory studies, there are limited studies on interventions and little use of social media in practice. However, information gleaned from the articles demonstrates the effectiveness of social media in supporting and improving public health and in identifying target populations for intervention. A primary recommendation resulting from the review is to

  14. American Samoa Energy Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    Haase, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Esterly, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States); Herdrich, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bodell, Tim [National Renewable Energy Lab. (NREL), Golden, CO (United States); Visser, Charles [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-08-01

    Describes the five near-term strategies selected by the American Samoa Renewable Energy Committee (ASREC) during action planning workshops conducted in May 2013, and outlines the actions being taken to implement those strategies. Each option is tied to a priority identified in the earlier draft American Samoa Strategic Energy Plan as being an essential component of reducing American Samoa'spetroleum energy consumption. The actions described for each strategy provide a roadmap to facilitate the implementation of each strategy. This document is intended to evolve along with the advancement of the projects, and will be updated to reflect progress.

  15. Review: Heinz Jürgen Kaiser & Hans Werbik (2012). Handlungspsychologie. Eine Einführung [The Psychology of Actions. An Introduction

    OpenAIRE

    Knaup, Marcus

    2013-01-01

    Since the mid-20th century, psychologists and philosophers have increasingly debated the validity and future prospects of the assumption that human behavior can be understood without reference to our desires, intentions, and imaginations. This raises the question of what basically constitutes human actions and what differentiates them from the behavior of bodies, stimuli, and events.In the work under review, this question is discussed and situated in the context of the psychology of actions. ...

  16. [Review of the effects of mindfulness meditation on mental and physical health and its mechanisms of action].

    Science.gov (United States)

    Ngô, Thanh-Lan

    2013-01-01

    Interventions based on mindfulness have become increasingly popular. This article reviews the empirical literature on its effects on mental and physical health, discusses presumed mechanisms of action as well as its proposed neurobiological underpinning. Mindfulness is associated with increased well-being as well as reduced cognitive reactivity and behavioral avoidance. It seems to contribute to enhance immune functions, diminish inflammation, diminish the reactivity of the autonomic nervous system, increase telomerase activity, lead to higher levels of plasmatic melatonin and serotonin. It enhances the quality of life for patients suffering from chronic pain, fibromylagia and HIV infection. It facilitates adaptation to the diagnosis of cancer and diabetes. It seems to lead to symptomatic improvement in irritable bowel syndrome, chronic fatigue syndrome, hot flashes, insomnia, stress related hyperphagia. It diminishes craving in substance abuse. The proposed mechanism of action are enhanced metacognitive conscience, interoceptive exposure, experiential acceptance, self-management, attention control, memory, relaxation. Six mechanism of actions for which neurological underpinnings have been published are: attention regulation (anterior cingulate cortex), body awareness (insula, temporoparietal junction), emotion regulation (modulation of the amygdala by the lateral prefrontal cortex), cognitive re-evaluation (activation of the dorsal medial prefrontal cortex or diminished activity in prefrontal regions), exposure/extinction/reconsolidation (ventromedial prefrontal cortex, hippocampus, amygdala) and flexible self-concept (prefrontal median cortex, posterior cingulated cortex, insula, temporoparietal junction). The neurobiological effects of meditation are described. These are: (1) the deactivation of the default mode network that generates spontaneous thoughts, contributes to the maintenance of the autobiographical self and is associated with anxiety and depression

  17. {A Review of Working Group 2 (Advanced Terrestrial Systems) of the COST 296 Action}

    Science.gov (United States)

    Warrington, E. M.; Tulunay, E.

    2009-04-01

    E.M. Warrington, E. Tulunay, N.M. Abbasi, J. Azevedo, L. Bertel, A. Bourdillon, E. Benito, C. Bianchi, A. Casimiro, L. Economou, Y. Erhel, S.M. Feeney, S.D. Gunashekar, H. Haralambous, D. Lemur, F. Marie, J.P. Monilie, M. Muriuki, M. Oger M. Pietrella, V. Rannou, H. Rothkaehl, S. Saillant, S. Salous, O. Sari, A.J. Stocker, H.J. Strangeways, Y. Tulunay and N.Y. Zaalov This paper deals with the research undertaken during the COST 296 Action in Working Group 2 on Advanced Terrestrial Systems. The Working Group comprised three work packages covering various topics: Radar and Radiolocation, HF/MF Communications, and Spectrum Management. Results from this Working Group are presented in this paper, and may be summarised as follows. Aspects of HF propagation The propagation characteristics of radio signals are important parameters to consider when designing and operating radio systems. From the point of view Working Group 2 of the COST-296 Action, interest lies with effects associated with propagation via the ionosphere of signals within the HF band. Several aspects were covered: The directions of arrival and times of flight of signals received over a path oriented along the trough have been examined and several types of propagation effects identified. Of particular note, combining the HF observations with satellite measurements has identified the presence of irregularities within the floor of the trough that result in propagation displaced from the great circle direction. An understanding of the propagation effects that result in deviations of the signal path from the great circle direction are of particular relevance to the operation of HF radiolocation systems. Inclusion of the results from the above mentioned measurements into a propagation model of the northerly ionosphere (i.e. those regions of the ionosphere located poleward of, and including, the mid-latitude trough) and the use of this model to predict the coverage expected from transmitters where the signals

  18. Safety and health in forest harvesting operations. Diagnosis and preventive actions. A review

    Energy Technology Data Exchange (ETDEWEB)

    Albizu-Urionabarrenetxea, P. M.; Tolosana-Esteban, E.; Roman-Jordan, E.

    2013-07-01

    Aim of study: to review the present state of the art in relation to the main labour risks and the most relevant results of recent studies evaluating the safety and health conditions of the forest harvesting work and better ways to reduce accidents. Area of study: It focuses mainly on developed Countries, where the general concern about work risks prevention, together with the complex idiosyncrasy of forest work in forest harvesting operations, has led to a growing interest from the forest scientific and technical community. Material and Methods: The main bibliographic and Internet references have been identified using common reference analysis tools. Their conclusions and recommendations have been comprehensively summarized. Main results: Collection of the principal references and their most important conclusions relating to the main accident risk factors, their causes and consequences, the means used towards their prevention, both instrumental as well as in the aspects of training and business management, besides the influence of the growing mechanization of logging operations on those risks. Research highlights: Accident risk is higher in forest harvesting than in most other work sectors, and the main risk factors such as experience, age, seasonality, training, protective equipment, mechanization degree, etc. have been identified and studied. The paper summarizes some relevant results, one of the principal being that the proper entrepreneurial risk management is a key factor leading to the success in minimizing labour risks. (Author)

  19. Safety and health in forest harvesting operations. Diagnosis and preventive actions. A review.

    Directory of Open Access Journals (Sweden)

    P. Albizu-Urionabarrenetxea

    2013-12-01

    Full Text Available Aim of study: to review the present state of the art in relation to the main labour risks and the most relevant results of recent studies evaluating the safety and health conditions of the forest harvesting work and better ways to reduce accidents.Area of study: It focuses mainly on developed Countries, where the general concern about work risks prevention, together with the complex idiosyncrasy of forest work in forest harvesting operations, has led to a growing interest from the forest scientific and technical community.Material and Methods: The main bibliographic and Internet references have been identified using common reference analysis tools. Their conclusions and recommendations have been comprehensively summarized.Main results: Collection of the principal references and their most important conclusions relating to the main accident risk factors, their causes and consequences, the means used towards their prevention, both instrumental as well as in the aspects of training and business management, besides the influence of the growing mechanization of logging operations on those risks.Research highlights: Accident risk is higher in forest harvesting than in most other work sectors, and the main risk factors such as experience, age, seasonality, training, protective equipment, mechanization degree, etc. have been identified and studied.   The paper summarizes some relevant results, one of the principal being that the proper entrepreneurial risk management is a key factor leading to the success in minimizing labour risks.Key words: labour risk; forestry; accident rates; preventive measures; entrepreneurial risk management.

  20. Phytochemistry and potential therapeutic actions of Boswellic acids: A mini-review

    Directory of Open Access Journals (Sweden)

    Farah Iram

    2017-06-01

    Full Text Available The pentacyclic triterpenic acids isolated from the oleo gum resin of various Boswellia species are collectively called as Boswellic acids (BA. The oleo gum resin obtained from Indian variety i.e. Boswellia serrata (Family – Burseraceae is commonly known as Salai guggal. The resin fraction of Salai guggal is rich in Boswellic acids and its essential oil is composed of a mixture of mono, di and sesquiterpenes while gum fraction chiefly contains pentose and hexose sugars. This oleo-gum resin is quite popular among traditional practitioners of traditional Chinese and Indian Systems of medicine owing to their wide range of useful biological properties such as anti-inflammatory, anti-arthritic, anti-rheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, anti-microbial anti-fungal, anti-complementary and analgesic activity, etc. It has been used as a herbal medicine since the prehistoric time to cure acute and chronic ailments including inflammatory diseases. Phytochemical investigation of this herbal medicine lead to identification of Boswellic acids which are found to be novel, potent, specific anti-inflammatory agents due to non-redox inhibition of 5-lipoxygenase (5-LO enzyme. However, the other important targets of Boswellic acids also include topoisomerases, angiogenesis, and cytochrome p450 enzymes. This review is a sincere attempt to discuss and present the current status of therapeutic potential, phytochemical as well as pharmacological profile of Boswellic acids primarily obtained from B. serrata.

  1. A biased review of biases in Twitter studies on political collective action

    Directory of Open Access Journals (Sweden)

    Peter Cihon

    2016-08-01

    Full Text Available In recent years researchers have gravitated to Twitter and other social media platforms as fertile ground for empirical analysis of social phenomena. Social media provides researchers access to trace data of interactions and discourse that once went unrecorded in the offline world. Researchers have sought to use these data to explain social phenomena both particular to social media and applicable to the broader social world. This paper offers a minireview of Twitter-based research on political crowd behaviour. This literature offers insight into particular social phenomena on Twitter, but often fails to use standardized methods that permit interpretation beyond individual studies. Moreover, the literature fails to ground methodologies and results in social or political theory, divorcing empirical research from the theory needed to interpret it. Rather, investigations focus primarily on methodological innovations for social media analyses, but these too often fail to sufficiently demonstrate the validity of such methodologies. This minireview considers a small number of selected papers; we analyse their (often lack of theoretical approaches, review their methodological innovations, and offer suggestions as to the relevance of their results for political scientists and sociologists.

  2. Propolis: a review of its anti-inflammatory and healing actions

    Directory of Open Access Journals (Sweden)

    A. F. N. Ramos

    2007-01-01

    Full Text Available Tissue healing is an adaptive biological response by which the organism repairs damaged tissue. The initial stage of healing is represented by an acute inflammatory reaction, in which inflammatory cells migrate to damaged tissue and phagocyte debris. At a later stage, fibroblasts and endothelial cells proliferate and generate a scar. The occurrence of inflammatory processes and healing imperfections have been a concern for hundreds of years, especially for individuals with healing difficulties, such as diabetics and carriers of peripheral circulation deficiencies. A wide variety of natural products have been used as anti-inflammatory and healing agents, with propolis being a remarkable option. Propolis has been used in popular medicine for a very long time; however, it is not a drug intended for all diseases. Currently, the determination of quality standards of propolis-containing products is a major problem due to their varying pharmacological activities and chemical compositions. The aim of this review is to discuss the use of propolis with emphasis on its anti-inflammatory and healing properties.

  3. A biased review of biases in Twitter studies on political collective action

    Science.gov (United States)

    Cihon, Peter; Yasseri, Taha

    2016-08-01

    In recent years researchers have gravitated to Twitter and other social media platforms as fertile ground for empirical analysis of social phenomena. Social media provides researchers access to trace data of interactions and discourse that once went unrecorded in the offline world. Researchers have sought to use these data to explain social phenomena both particular to social media and applicable to the broader social world. This paper offers a minireview of Twitter-based research on political crowd behaviour. This literature offers insight into particular social phenomena on Twitter, but often fails to use standardized methods that permit interpretation beyond individual studies. Moreover, the literature fails to ground methodologies and results in social or political theory, divorcing empirical research from the theory needed to interpret it. Rather, investigations focus primarily on methodological innovations for social media analyses, but these too often fail to sufficiently demonstrate the validity of such methodologies. This minireview considers a small number of selected papers; we analyse their (often lack of) theoretical approaches, review their methodological innovations, and offer suggestions as to the relevance of their results for political scientists and sociologists.

  4. Friends interventions in psychosis: a narrative review and call to action.

    Science.gov (United States)

    Harrop, Chris; Ellett, Lyn; Brand, Rachel; Lobban, Fiona

    2015-08-01

    To highlight the importance of friendships to young people with psychosis, and the need for clinical interventions to help maintain peer relationships during illness. To structure a research agenda for developing evidence-based interventions with friends. An argument is developed through a narrative review of (i) the proven efficacy of family interventions, and (by comparison) a relative absence of friend-based interventions; (ii) the particular primacy of friendships and dating for young people, and typical effects of exclusion; and (iii) reduced friendship networks and dating experiences in psychosis, in pre-, during and post-psychosis phases, also links between exclusion and psychosis. We put forward a model of how poor friendships can potentially be a causal and/or maintenance factor for psychotic symptoms. Given this model, our thesis is that interventions aiming to maintain social networks can be hugely beneficial clinically for young people with psychosis. We give a case study to show how such an intervention can work. We call for 'friends interventions' for young people with psychosis to be developed, where professionals directly work with a young person's authentic social group to support key friendships and maintain social continuity. An agenda for future research is presented that will develop and test theoretically driven interventions. © 2014 Wiley Publishing Asia Pty Ltd.

  5. PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Insulin action and lipotoxicity in the development of polycystic ovary syndrome: A review.

    Science.gov (United States)

    Faubert, J; Battista, M-C; Baillargeon, J-P

    2016-05-01

    Polycystic ovary syndrome (PCOS) is a common condition affecting women of reproductive age. This disorder is characterized by hyperandrogenism and anovulation and is frequently associated with comorbidities such as infertility, metabolic syndrome, type 2 diabetes, and cardiovascular risk factors. Although the causes of PCOS are unknown, this review focuses on the most accepted theory involving insulin action but will also elaborate on a novel concept: the role of lipotoxicity in the development of androgen overproduction, in addition to its known role in insulin resistance. This review will also shed a spotlight on 2 drugs that target lipotoxicity and are, therefore, known or promising for the treatment of PCOS manifestations: peroxisome proliferator-activated receptor γ and angiotensin II type 2 receptor agonists. This paper, therefore, emphasizes the need to further explore the pathophysiology of PCOS and particularly the role of lipotoxicity. Indeed, this new mechanism deserves attention to develop therapeutic approaches that will directly target the root of this condition and not only bandage its associated consequences.

  6. Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review

    Directory of Open Access Journals (Sweden)

    Mallappa Kumara Swamy

    2016-01-01

    Full Text Available A wide range of medicinal and aromatic plants (MAPs have been explored for their essential oils in the past few decades. Essential oils are complex volatile compounds, synthesized naturally in different plant parts during the process of secondary metabolism. Essential oils have great potential in the field of biomedicine as they effectively destroy several bacterial, fungal, and viral pathogens. The presence of different types of aldehydes, phenolics, terpenes, and other antimicrobial compounds means that the essential oils are effective against a diverse range of pathogens. The reactivity of essential oil depends upon the nature, composition, and orientation of its functional groups. The aim of this article is to review the antimicrobial potential of essential oils secreted from MAPs and their possible mechanisms of action against human pathogens. This comprehensive review will benefit researchers who wish to explore the potential of essential oils in the development of novel broad-spectrum key molecules against a broad range of drug-resistant pathogenic microbes.

  7. Emotions predictably modify response times in the initiation of human motor actions: A meta-analytic review.

    Science.gov (United States)

    Beatty, Garrett F; Cranley, Nicole M; Carnaby, Giselle; Janelle, Christopher M

    2016-03-01

    Emotions motivate individuals to attain appetitive goals and avoid aversive consequences. Empirical investigations have detailed how broad approach and avoidance orientations are reflected in fundamental movement attributes such as the speed, accuracy, and variability of motor actions. Several theoretical perspectives propose explanations for how emotional states influence the speed with which goal directed movements are initiated. These perspectives include biological predisposition, muscle activation, distance regulation, cognitive evaluation, and evaluative response coding accounts. A comprehensive review of literature and meta-analysis were undertaken to quantify empirical support for these theoretical perspectives. The systematic review yielded 34 studies that contained 53 independent experiments producing 128 effect sizes used to evaluate the predictions of existing theories. The central tenets of the biological predisposition (Hedges' g = -0.356), distance regulation (g = -0.293; g = 0.243), and cognitive evaluation (g = -0.249; g = -0.405; g = -0.174) accounts were supported. Partial support was also identified for the evaluative response coding (g = -0.255) framework. Our findings provide quantitative evidence that substantiate existing theoretical perspectives, and provide potential direction for conceptual integration of these independent perspectives. Recommendations for future empirical work in this area are discussed. (c) 2016 APA, all rights reserved).

  8. A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action

    Directory of Open Access Journals (Sweden)

    Lynne Bell

    2015-12-01

    Full Text Available Flavonoids are polyphenolic compounds found in varying concentrations in many plant-based foods. Recent studies suggest that flavonoids can be beneficial to both cognitive and physiological health. Long term flavonoid supplementation over a period of weeks or months has been extensively investigated and reviewed, particularly with respect to cognitive ageing and neurodegenerative disease. Significantly less focus has been directed towards the short term effects of single doses of flavonoids on cognition. Here, we review 21 such studies with particular emphasis on the subclass and dose of flavonoids administered, the cognitive domains affected by flavonoid supplementation, and the effect size of the response. The emerging evidence suggests that flavonoids may be beneficial to attention, working memory, and psychomotor processing speed in a general population. Episodic memory effects are less well defined and may be restricted to child or older adult populations. The evidence also points towards a dose-dependent effect of flavonoids, but the physiological mechanisms of action remain unclear. Overall, there is encouraging evidence that flavonoid supplementation can benefit cognitive outcomes within an acute time frame of 0–6 h. But larger studies, combining cognitive and physiological measures, are needed to strengthen the evidence base.

  9. Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review

    Science.gov (United States)

    2016-01-01

    A wide range of medicinal and aromatic plants (MAPs) have been explored for their essential oils in the past few decades. Essential oils are complex volatile compounds, synthesized naturally in different plant parts during the process of secondary metabolism. Essential oils have great potential in the field of biomedicine as they effectively destroy several bacterial, fungal, and viral pathogens. The presence of different types of aldehydes, phenolics, terpenes, and other antimicrobial compounds means that the essential oils are effective against a diverse range of pathogens. The reactivity of essential oil depends upon the nature, composition, and orientation of its functional groups. The aim of this article is to review the antimicrobial potential of essential oils secreted from MAPs and their possible mechanisms of action against human pathogens. This comprehensive review will benefit researchers who wish to explore the potential of essential oils in the development of novel broad-spectrum key molecules against a broad range of drug-resistant pathogenic microbes. PMID:28090211

  10. Report: Review of Conflict of Interest AllegationsPertaining to the Peer Review of EPA’s Draft Report, “Exposure and Human Health Evaluation of Airborne Pollution from the World Trade Center Disaster”

    Science.gov (United States)

    Report #2005-S-00003, November 4, 2004. We found that EPA’s Contractor did not inquire whether the three panelists had received funding from industry or had publically expressed viewpoints on the issues to be reviewed.

  11. Pictorial Drawings. Drafting Module 5. Instructor's Guide.

    Science.gov (United States)

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. This unit contains information on pictorial drawings. The guide contains a cross-reference table of instructional materials. The unit contains the following:…

  12. Construction Techniques. Drafting Module 2. Instructor's Guide.

    Science.gov (United States)

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. The guide contains a cross-reference table of instructional materials. Four units cover construction techniques: (1) drawing sheet layout; (2) sketching; (3)…

  13. 76 FR 5154 - Availability of Draft Report, Biofuels and the Environment: First Triennial Report to Congress

    Science.gov (United States)

    2011-01-28

    ...EPA is announcing that it will convene an independent panel of experts to review the external review draft document titled, Biofuels and the Environment: The First Triennial Report to Congress (EPA/600/R- 10/183A). The peer review meeting will be organized by Versar, Inc., an EPA contractor for external scientific peer review. The EPA also is announcing a 30-day public comment period for the draft document. The draft document was prepared by the National Center for Environmental Assessment (NCEA) within EPA's Office of Research and Development. The 2007 Energy Independence and Security Act (EISA) mandates increased production of biofuels (fuels derived from organic materials) from 9 billion gallons per year in 2008 to 36 billion gallons per year by 2022. EISA (Section 204) also requires the U.S. Environmental Protection Agency (EPA) to assess and report to Congress every three years on the current and potential future environmental and resource conservation impacts associated with increased biofuel production and use. Biofuels and the Environment: First Triennial Report to Congress is the first report on this issue. The public comment period and the external peer review meeting are separate processes that provide opportunities for all interested parties to comment on the document. EPA intends to forward public comments that are submitted in accordance with this notice, to the external peer review panel, prior to the meeting for their consideration. When finalizing the draft document, EPA intends to consider any public comments that EPA receives in accordance with this notice. EPA is releasing this draft document solely for the purpose of obtaining public comment and peer review under applicable information quality guidelines. This document does not represent and should not be construed to represent any Agency policy or determination. EPA, through its Peer Review contractor, Versar, Inc., invites the public to register to attend the peer review meeting. In

  14. Book Review: Gomez, Edmund Terence, and Johan Saravanamuttu (eds (2012, The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice

    Directory of Open Access Journals (Sweden)

    Frederik Holst

    2013-01-01

    Full Text Available Book Review of the edited compilation: Gomez, Edmund Terence, and Johan Saravanamuttu (eds (2012, The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice; Singapore: NUS Press, ISBN 978-697-5832-67-3, 412 pages

  15. 41 CFR 102-118.650 - Can a TSP request a review of a settlement action by the Administrator of General Services?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Can a TSP request a... Procedures Transportation Service Provider (tsp) and Agency Appeal Procedures for Postpayment Audits § 102-118.650 Can a TSP request a review of a settlement action by the Administrator of General Services...

  16. Draft revision of human factors guideline HF-010

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyun Chul; Lee, Yong Hee; Oh, In Seok; Lee, Jung Woon [KAERI, Taejon (Korea, Republic of); Cha, Woo Chang [Kumoh National Institute of Technology, Gumi (Korea, Republic of); Lee, Dhong Ha [Suwon University, Suwon (Korea, Republic of)

    2003-05-01

    The Application of Human Factors to the design of Man-Machine Interfaces System(MMIS) in the nuclear power plant is essential to the safety and productivity of the nuclear power plants, human factors standards and guidelines as well as human factors analysis methods and experiments are weightily used to the design application. A Korean engineering company has developed a human factors engineering guideline, so-call HF-010, and has used it for human factors design, however the revision of HF-010 is necessary owing to lack of the contents related to the advanced MMI(Man-Machine Interfaces). As the results of the reviews of HF-010, it is found out that the revision of Section 9. Computer Displays of HF-010 is urgent, thus the revision was drafted on the basis of integrated human factors design guidelines for VDT, human factors design guidelines for PMAS SPADES display, human factors design guidelines for PMAS alarm display, and human factors design guidelines for electronic displays developed by the surveillance and operation support project of KOICS. The draft revision of HF-010 Section 9 proposed in this report can be utilized for the human factors design of the advanced MMI, and the high practical usability of the draft can be kept up through the continuous revision according to the advancement of digital technology.

  17. Weldon Spring Site Remedial Action Project: Report from the DOE voluntary protection program onsite review, November 17--21, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-28

    This report summarizes the Department of Energy Voluntary Protection Program (DOE-VPP) Review Team`s findings from the five-day onsite evaluation of the Weldon Spring Site Remedial Action Project (WSSRAP), conducted November 17--21, 1997. The site was evaluated against the program requirements contained in ``US Department of Energy Voluntary Protection Program, Part 1: Program Elements`` to determine its success in implementing the five tenets of DOE-VPP. DOE-VPP consists of three programs, with names and functions similar to those in OSHA`s VPP. These programs are STAR, MERIT, and DEMONSTRATION. The STAR program is the core of DOE-VPP. The program is aimed at truly outstanding protectors of employee safety and health. The MERIT program is a steppingstone for contractors and subcontractors that have good safety and health programs but need time and DOE guidance to achieve STAR status. The DEMONSTRATION program is rarely used; it allows DOE to recognize achievements in unusual situations about which DOE needs to learn more before determining approval requirements for the STAR status.

  18. Optimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of action

    Directory of Open Access Journals (Sweden)

    Damal K

    2013-11-01

    Full Text Available Kavitha Damal, Emily Stoker, John F FoleyRocky Mountain Multiple Sclerosis Research Group, Salt Lake City, UT, USAAbstract: Multiple sclerosis (MS is a debilitating neurological disorder that affects nearly 2 million adults, mostly in their prime of youth. An environmental trigger, such as a viral infection, is hypothesized to initiate the abnormal behavior of host immune cells: to attack and damage the myelin sheath surrounding the neurons of the central nervous system. While several other pathways and disease triggers are still being investigated, it is nonetheless clear that MS is a heterogeneous disease with multifactorial etiologies that works independently or synergistically to initiate the aberrant immune responses to myelin. Although there are still no definitive markers to diagnose the disease or to cure the disease per se, research on management of MS has improved many fold over the past decade. New disease-modifying therapeutics are poised to decrease immune inflammatory responses and consequently decelerate the progression of MS disease activity, reduce the exacerbations of MS symptoms, and stabilize the physical and mental status of individuals. In this review, we describe the mechanism of action, optimal dosing, drug administration, safety, and efficacy of the disease-modifying therapeutics that are currently approved for MS therapy. We also briefly touch upon the new drugs currently under investigation, and discuss the future of MS therapeutics.Keywords: multiple sclerosis, immunomodulation, interferons, glatiramer acetate, monoclonal antibodies, dimethyl fumarate

  19. A review of synaptic mechanisms of vestibular efferent signaling in turtles: extrapolation to efferent actions in mammals.

    Science.gov (United States)

    Jordan, Paivi M; Parks, Xiaorong Xu; Contini, Donatella; Holt, J Chris

    2013-01-01

    The vestibular labyrinth of nearly every vertebrate class receives a prominent efferent innervation that originates in the brainstem and ends as bouton terminals on vestibular hair cells and afferents in each end organ. Although the functional significance of this centrifugal pathway is not well understood, it is clear that efferent neurons, when electrically stimulated under experimental conditions, profoundly impact vestibular afferent discharge. Effects range from chiefly excitation in fish and mammalian vestibular afferents to a more heterogeneous mixture of inhibition and/or excitation in amphibians, reptiles, and birds. What accounts for these diverse response properties? Recent cellular and pharmacological characterization of efferent synaptic mechanisms in turtle offers some insight. In the turtle posterior crista, vestibular efferent neurons are predominantly cholinergic and the effects of efferent stimulation on vestibular afferent discharge can be ascribed to three distinct signaling pathways: (1) Hyperpolarization of type II hair cells mediated by α9/α10-nAChRs and SK-potassium channels; (2) Depolarization of bouton and calyx afferents via α4β2*-containing nAChRs; and (3) A slow excitation of calyx afferents attributed to muscarinic AChRs. In this review, we discuss the evidence for these pathways in turtle and speculate on their role in mammalian vestibular efferent actions where synaptic mechanisms are largely unknown.

  20. Predicted percentage dissatisfied with ankle draft.

    Science.gov (United States)

    Liu, S; Schiavon, S; Kabanshi, A; Nazaroff, W W

    2017-07-01

    Draft is unwanted local convective cooling. The draft risk model of Fanger et al. (Energy and Buildings 12, 21-39, 1988) estimates the percentage of people dissatisfied with air movement due to overcooling at the neck. There is no model for predicting draft at ankles, which is more relevant to stratified air distribution systems such as underfloor air distribution (UFAD) and displacement ventilation (DV). We developed a model for predicted percentage dissatisfied with ankle draft (PPDAD ) based on laboratory experiments with 110 college students. We assessed the effect on ankle draft of various combinations of air speed (nominal range: 0.1-0.6 m/s), temperature (nominal range: 16.5-22.5°C), turbulence intensity (at ankles), sex, and clothing insulation (thermal sensation and air speed at ankles are the dominant parameters affecting draft. The seated subjects accepted a vertical temperature difference of up to 8°C between ankles (0.1 m) and head (1.1 m) at neutral whole-body thermal sensation, 5°C more than the maximum difference recommended in existing standards. The developed ankle draft model can be implemented in thermal comfort and air diffuser testing standards. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Evaluation of Worktext in Mechanical Drafting

    Directory of Open Access Journals (Sweden)

    Erich D. Cruz

    2015-11-01

    Full Text Available This study aimed to evaluate Worktext in Drafting Technology 4 (Mechanical Drafting for Bachelor of Technology (BT major in Drafting Technology. It was conducted at University of Rizal System with twenty Drafting and Mechanical Technology professors as respondents. The study used the descriptive evaluative method to describe and evaluate the developed Worktext in DT 4 using the questionnaire-checklist in gathering data. They were asked to evaluate the worktext through the following: objectives, contents, activities, presentation and style, organization, creativity, evaluation, accuracy, completeness and appropriateness. It was found out that the developed worktext with respect to objectives was highly agree, contents was highly agree, activities was highly agree, presentation and style was agree, creativity was highly agree and evaluation was highly agree. Meaning that the items with highly agree interpretations attained excellent level of acceptability while those with agree interpretations obtained extensive level of acceptability with fully achieved and above average Drafting standards, respectively. It was also found out that the developed worktext in terms of accuracy was high, completeness was very high and appropriateness was likewise very high. The researcher recommends that the developed Worktext in Drafting Technology 4 may be adopted for use by the Bachelor of Technology major in Drafting Technology students.

  2. 10 CFR 51.74 - Distribution of draft environmental impact statement and supplement to draft environmental impact...

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Distribution of draft environmental impact statement and supplement to draft environmental impact statement; news releases. 51.74 Section 51.74 Energy NUCLEAR... Impact Statements § 51.74 Distribution of draft environmental impact statement and supplement to draft...

  3. 78 FR 73555 - Deepwater Horizon Oil Spill; Draft Programmatic and Phase III Early Restoration Plan and Draft...

    Science.gov (United States)

    2013-12-06

    ... Environmental Impact Statement (Draft Phase III ERP/PEIS). The Draft Phase III ERP/PEIS considers programmatic... programmatic restoration alternatives. The Draft Phase III ERP/PEIS evaluates these restoration alternatives... the Framework Agreement. The Draft Phase III ERP/PEIS also evaluates the environmental consequences of...

  4. 75 FR 17951 - Notice Re-opening the Comment Period for the Draft Resource Management Plan and Draft...

    Science.gov (United States)

    2010-04-08

    ... Bureau of Land Management Notice Re-opening the Comment Period for the Draft Resource Management Plan and Draft Environmental Impact Statement for the Clear Creek Management Area, California AGENCY: Bureau of...-opening of the comment period on the Draft Resource Management Plan (RMP) and Draft Environmental Impact...

  5. Predicted percentage dissatisfied with ankle draft

    OpenAIRE

    Liu, S.; Schiavon, S; Kabanshi, A; Nazaroff, WW

    2017-01-01

    © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Draft is unwanted local convective cooling. The draft risk model of Fanger et al. (Energy and Buildings 12, 21-39, 1988) estimates the percentage of people dissatisfied with air movement due to overcooling at the neck. There is no model for predicting draft at ankles, which is more relevant to stratified air distribution systems such as underfloor air distribution (UFAD) and displacement ventilation (DV). We developed a mode...

  6. Yakima Fisheries Project : Revised Draft Environmental Impact Statement.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-05-01

    BPA proposes to fund several fishery-related activities in the Yakima River Basin. The Yakima Fisheries Project (YFP), included in the Northwest Power Planning Council`s fish and wildlife program, would be jointly managed by the State of Washington and the Yakima Indian Nation. Fisheries resources in the Yakima River are severely reduced from historical levels and there is a significant potential for enhancement of these resources. BPA`s proposed action is to fund (1) information gathering on the implementation of supplementation techniques and on feasibility of reintroducing coho salmon in an environment where native populations have become extinct; (2) research activities based on continuous assessment, feedback and improvement of research design and activities ({open_quotes}adaptive management{close_quotes}); and (3) the construction, operation, and maintenance of facilities for supplementing populations of upper Yakima spring chinook salmon. The project has been considerably revised from the original proposal described in the first draft EIS. Examined in addition to No Action (which would leave present anadromous fisheries resources unchanged in the, Basin) are two alternatives for action: (1) supplementation of depressed natural populations of upper Yakima spring chinook and (2) that same supplementation plus a study to determine the feasibility of re-establishing (via stock imported from another basin) naturally spawning population and a significant fall fishery for coho in the Yakima Basin. Alternative 2 has been identified as the preferred action. Major issues examined in the Revised Draft EIS include potential impacts of the project on genetic and ecological resources of existing fish populations, on water quality and quantity, on threatened and endangered species listed under the Endangered Species Act, and on the recreational fishery.

  7. 76 FR 59732 - Draft Environmental Impact Statement and Draft Habitat Conservation Plan for Oncor Electric...

    Science.gov (United States)

    2011-09-27

    ... draft HCP, which describes the conservation measures the Applicant has agreed to undertake to minimize...). Joy E. Nicholopoulos, Acting Regional Director, Southwest Region, Albuquerque, New Mexico. BILLING...

  8. The hydrodynamics of dolphin drafting

    Directory of Open Access Journals (Sweden)

    Weihs Daniel

    2004-05-01

    Full Text Available Abstract Background Drafting in cetaceans is defined as the transfer of forces between individuals without actual physical contact between them. This behavior has long been surmised to explain how young dolphin calves keep up with their rapidly moving mothers. It has recently been observed that a significant number of calves become permanently separated from their mothers during chases by tuna vessels. A study of the hydrodynamics of drafting, initiated in the hope of understanding the mechanisms causing the separation of mothers and calves during fishing-related activities, is reported here. Results Quantitative results are shown for the forces and moments around a pair of unequally sized dolphin-like slender bodies. These include two major effects. First, the so-called Bernoulli suction, which stems from the fact that the local pressure drops in areas of high speed, results in an attractive force between mother and calf. Second is the displacement effect, in which the motion of the mother causes the water in front to move forwards and radially outwards, and water behind the body to move forwards to replace the animal's mass. Thus, the calf can gain a 'free ride' in the forward-moving areas. Utilizing these effects, the neonate can gain up to 90% of the thrust needed to move alongside the mother at speeds of up to 2.4 m/sec. A comparison with observations of eastern spinner dolphins (Stenella longirostris is presented, showing savings of up to 60% in the thrust that calves require if they are to keep up with their mothers. Conclusions A theoretical analysis, backed by observations of free-swimming dolphin schools, indicates that hydrodynamic interactions with mothers play an important role in enabling dolphin calves to keep up with rapidly moving adult school members.

  9. 76 FR 24512 - Laguna Cartagena National Wildlife Refuge, Lajas, Puerto Rico; Draft Comprehensive Conservation...

    Science.gov (United States)

    2011-05-02

    ... Fish and Wildlife Service Laguna Cartagena National Wildlife Refuge, Lajas, Puerto Rico; Draft... CCP/EA) for Laguna Cartagena National Wildlife Refuge (NWR) for public review and comment. In the... Cartagena NWR. We started the process through a notice of intent in the Federal Register on May 16, 2007 (72...

  10. 77 FR 43609 - Endangered and Threatened Wildlife and Plants; Incidental Take Permit Application; Draft...

    Science.gov (United States)

    2012-07-25

    .... SUMMARY: We, the U.S. Fish and Wildlife Service, have received applications from the Rio Grande Water... HCP and draft environmental assessment for review and comment by the public and Federal, Tribal, State... Colorado Division of Water Resources, the Alamosa Mosquito Control District, the San Luis Valley Water...

  11. 76 FR 61103 - Draft Guidance for Industry and Food and Drug Administration Staff; De Novo Classification...

    Science.gov (United States)

    2011-10-03

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... staff and industry on the process for the submission and review of petitions submitted under the Federal Food, Drug, and Cosmetic Act (FD&C Act), also known as the de novo classification process. FDA is...

  12. 10 CFR 51.33 - Draft finding of no significant impact; distribution.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Draft finding of no significant impact; distribution. 51.33 Section 51.33 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION... review and comment before making a final determination whether to prepare an environmental impact...

  13. A National Program for Library and Information Services. 2nd Draft (Rev.).

    Science.gov (United States)

    National Commission on Libraries and Information Science, Washington, DC.

    The second draft of the National Commission on Libraries and Information Science (NCLIS) report proposes a national program to offer the most information service to the greatest number of people. Current status and problems in all kinds of libraries are reviewed, including: distribution of resources; uneven access to information; the influence of…

  14. 78 FR 18665 - Proposed Keystone XL Project; Public Meeting Following Release of the Draft Supplemental Impact...

    Science.gov (United States)

    2013-03-27

    ... Presidential Permit application for the proposed Keystone XL pipeline. The document is a draft technical review... turn is called or they will forfeit their time. Comments: Remarks made at the meeting will be recorded... to make remarks, to allow the maximum number of people who sign up to speak. Speakers will be asked...

  15. 78 FR 27115 - Draft Guidance for Industry on Expanded Access to Investigational Drugs for Treatment Use...

    Science.gov (United States)

    2013-05-09

    ... access under each of the three access categories, the types and content of access submissions, IRB review... appropriate ethical oversight. This draft guidance is being issued consistent with FDA's good guidance... docket at http://www.regulations.gov . IV. Electronic Access Persons with access to the Internet may...

  16. 76 FR 19741 - Draft Environmental Assessment; Giant Miscanthus in Arkansas, Missouri, Ohio, and Pennsylvania

    Science.gov (United States)

    2011-04-08

    ... a dedicated energy crop to be grown in the Aloterra Energy and MFA Oil Biomass Company (project... (voice and TDD). SUPPLEMENTARY INFORMATION: The Aloterra Energy and MFA Oil Biomass Company submitted a... Energy LLC and MFA Oil Biomass LLC is now available to review for the environmental impact. The draft EA...

  17. Nanostructured materials for solid-state hydrogen storage: A review of the achievement of COST Action MP1103

    NARCIS (Netherlands)

    Callini, Elsa; Aguey-Zinsou, Kondo Francois; Ahuja, Rajeev; Ares, Jos Ramon; Bals, Sara; Biliskov, Nikola; Chakraborty, Sudip; Charalambopoulou, Georgia; Chaudhary, Anna Lisa; Cuevas, Fermin; Dam, Bernard; de Jongh, Petra; Dornheim, Martin; Filinchuk, Yaroslav; Novakovic, Jasmina G.; Hirscher, Michael; Hirscher, M.; Jensen, Torben R.; Jensen, Peter Bjerre; Novakovic, Nikola; Lai, Qiwen; Leardini, Fabrice; Gattia, Daniele Mirabile; Pasquini, Luca; Steriotis, Theodore; Turner, Stuart; Vegge, Tejs; Zuttel, Andreas; Montone, Amelia

    2016-01-01

    In the framework of the European Cooperation in Science and Technology (COST) Action MP1103 Nanostructured Materials for Solid-State Hydrogen Storage were synthesized, characterized and modeled. This Action dealt with the state of the art of energy storage and set up a competitive and coordinated

  18. Actionable Nuggets

    Science.gov (United States)

    McColl, Mary Ann; Aiken, Alice; Smith, Karen; McColl, Alexander; Green, Michael; Godwin, Marshall; Birtwhistle, Richard; Norman, Kathleen; Brankston, Gabrielle; Schaub, Michael

    2015-01-01

    Abstract Objective To present the results of a pilot study of an innovative methodology for translating best evidence about spinal cord injury (SCI) for family practice. Design Review of Canadian and international peer-reviewed literature to develop SCI Actionable Nuggets, and a mixed qualitative-quantitative evaluation to determine Nuggets’ effect on physician knowledge of and attitudes toward patients with SCI, as well as practice accessibility. Setting Ontario, Newfoundland, and Australia. Participants Forty-nine primary care physicians. Methods Twenty Actionable Nuggets (pertaining to key health issues associated with long-term SCI) were developed. Nugget postcards were mailed weekly for 20 weeks to participating physicians. Prior knowledge of SCI was self-rated by participants; they also completed an online posttest to assess the information they gained from the Nugget postcards. Participants’ opinions about practice accessibility and accommodations for patients with SCI, as well as the acceptability and usefulness of Nuggets, were assessed in interviews. Main findings With Actionable Nuggets, participants’ knowledge of the health needs of patients with SCI improved, as knowledge increased from a self-rating of fair (58%) to very good (75%) based on posttest quiz results. The mean overall score for accessibility and accommodations in physicians’ practices was 72%. Participants’ awareness of the need for screening and disease prevention among this population also increased. The usefulness and acceptability of SCI Nugget postcards were rated as excellent. Conclusion Actionable Nuggets are a knowledge translation tool designed to provide family physicians with concise, practical information about the most prevalent and pressing primary care needs of patients with SCI. This evidence-based resource has been shown to be an excellent fit with information consumption processes in primary care. They were updated and adapted for distribution by the Canadian

  19. 78 FR 74162 - Draft Criminal Justice Offender Tracking System Standard and Companion Documents

    Science.gov (United States)

    2013-12-10

    ... of Justice Programs Draft Criminal Justice Offender Tracking System Standard and Companion Documents... draft documents: (1) A draft standard entitled, ``Criminal Justice Offender Tracking System Standard''; (2) a draft companion document entitled, ``Criminal Justice Offender Tracking System Certification...

  20. Theory of reasoned action and theory of planned behavior-based dietary interventions in adolescents and young adults: a systematic review

    OpenAIRE

    Hackman CL; Knowlden AP

    2014-01-01

    Christine L Hackman, Adam P KnowldenDepartment of Health Science, The University of Alabama, Tuscaloosa, AL, USABackground: Childhood obesity has reached epidemic proportions in many nations around the world. The theory of planned behavior (TPB) and the theory of reasoned action (TRA) have been used to successfully plan and evaluate numerous interventions for many different behaviors. The aim of this study was to systematically review and synthesize TPB and TRA-based dietary behavior interven...

  1. The baby or the bath water? Lessons learned from the National Action Alliance for Suicide Prevention Research Prioritization Task Force literature review.

    Science.gov (United States)

    Davis Molock, Sherry; Heekin, Janet M; Matlin, Samantha G; Barksdale, Crystal L; Gray, Ekwenzi; Booth, Chelsea L

    2014-09-01

    The Research Prioritization Task Force of the National Action Alliance for Suicide Prevention conducted a comprehensive literature review of suicide prevention/intervention trials to assess the quality of the scientific evidence. A literature "review of reviews" was conducted by searching the most widely used databases for mental health and public health research. The quality of the reviews was evaluated using the Revised Assessment of Multiple Systematic Reviews system; the quality of the scientific evidence for the suicide preventions/interventions was assessed using U.S. Preventive Services Task Force criteria. The reviews were limited to peer-reviewed publications with human subjects published in English. Ninety-eight systematic reviews and 45 primary sources on suicide prevention/interventions published between January 2000 and September 2012 were evaluated. The results suggest that the quality of both the systematic reviews and the scientific evidence for suicide preventions/interventions were mixed. The majority of the systematic reviews and prevention/interventions were evaluated as fair to poor in quality. There are many promising suicide prevention/intervention trials, but research findings are often inconclusive because of methodologic problems. Methodologic problems across systematic reviews include not conducting hand searches, not surveying gray literature, and being unable to aggregate data across studies. Methodologic problems with the scientific quality of the prevention/intervention trials include paucity of information on sample demographic characteristics, poorly defined outcomes, and excluding actively suicidal participants. Suggestions for ways to improve the quality of the systematic reviews and suicide preventions/interventions are provided. Copyright © 2014 American Journal of Preventive Medicine. All rights reserved.

  2. 77 FR 36573 - DRAFT General Management Plan and Draft Environmental Impact Statement, Fort Matanzas National...

    Science.gov (United States)

    2012-06-19

    ... National Park Service DRAFT General Management Plan and Draft Environmental Impact Statement, Fort Matanzas... Matanzas National Monument (Monument), Florida. Consistent with NPS laws, regulations, and policies and the... http://parkplanning.nps.gov/FOMA . To request a copy, contact Fort Matanzas National Monument...

  3. 77 FR 42756 - Draft Environmental Impact Statement and Draft Habitat Conservation Plan for Incidental Take of...

    Science.gov (United States)

    2012-07-20

    ... Texas troglobitic water slater (Lirceolus smithii) in case they are listed during the duration of the..., and the Edwards Aquifer Authority; San Antonio Water Systems; City of New Braunfels, Texas; City of... Fish and Wildlife Service Draft Environmental Impact Statement and Draft Habitat Conservation Plan for...

  4. 78 FR 39253 - Notice of Extension of Comment Period for Draft Initial Comprehensive Plan and Draft...

    Science.gov (United States)

    2013-07-01

    ... Members also have compiled preliminary lists of ecosystem restoration projects that are ``authorized but... commenced'' ecosystem restoration projects, and Draft PEA by either of the following methods: Electronic... preliminary lists of ``authorized but not yet commenced'' ecosystem restoration projects, and the Draft PEA...

  5. 78 FR 37230 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2013-06-20

    ... current thinking on product-specific design of BE studies to support ANDAs. They do not create or confer... HUMAN SERVICES Food and Drug Administration Draft and Revised Draft Guidances for Industry Describing... provide product-specific guidance on the design of BE studies to support abbreviated new drug applications...

  6. 77 FR 74669 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2012-12-17

    ... Agency's current thinking on product-specific design of BE studies to support ANDAs. They do not create... HUMAN SERVICES Food and Drug Administration Draft and Revised Draft Guidances for Industry Describing... provide product-specific guidance on the design of BE studies to support abbreviated new drug applications...

  7. 77 FR 56851 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2012-09-14

    ... HUMAN SERVICES Food and Drug Administration Draft and Revised Draft Guidances for Industry Describing... provide product-specific guidance on the design of BE studies to support abbreviated new drug applications... practices regulation (21 CFR 10.115). These guidances represent the Agency's current thinking on product...

  8. 78 FR 66745 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2013-11-06

    ... thinking on product-specific design of BE studies to support ANDAs. They do not create or confer any rights... HUMAN SERVICES Food and Drug Administration Draft and Revised Draft Guidances for Industry Describing... provide product-specific guidance on the design of BE studies to support abbreviated new drug applications...

  9. 76 FR 19784 - Notice of Availability of the Draft Environmental Impact Statement and Draft Resource Management...

    Science.gov (United States)

    2011-04-08

    ... Resource Management Plan Amendment to the 1987 Jarbidge Resource Management Plan for the Proposed China... prepared a Draft Environmental Impact Statement (EIS) and a Draft Resource Management Plan (RMP) Amendment... is not in conformance with the 1987 Jarbidge RMP provisions regarding Visual Resource Management (VRM...

  10. 77 FR 57094 - Draft Guidance for Industry on Self-Identification of Generic Drug Facilities, Sites, and...

    Science.gov (United States)

    2012-09-17

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Self-Identification of Generic Drug Facilities, Sites, and Organizations; Availability; Correction AGENCY: Food and Drug Administration, HHS. ACTION: Notice; correction. SUMMARY: The Food and Drug Administration (FDA) is correcting a...

  11. 76 FR 20686 - Draft Guidance for Industry on Safety Labeling Changes; Implementation of the Federal Food, Drug...

    Science.gov (United States)

    2011-04-13

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Safety Labeling Changes; Implementation of the Federal Food, Drug, and Cosmetic Act; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of...

  12. 75 FR 76467 - Draft Concept for Government-Wide “ExpertNet” Platform and Process To Elicit Expert Public...

    Science.gov (United States)

    2010-12-08

    ... ADMINISTRATION Draft Concept for Government-Wide ``ExpertNet'' Platform and Process To Elicit Expert Public Participation in Response to Government Questions AGENCY: U.S. General Services Administration. ACTION: Notice; request for public comment. SUMMARY: With this notice, the U.S. General Services Administration (GSA...

  13. 78 FR 64428 - Draft Qualitative Risk Assessment of Risk of Activity/Animal Food Combinations for Activities...

    Science.gov (United States)

    2013-10-29

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 507 Draft Qualitative Risk Assessment of Risk of...-Located on a Farm; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notification; request for comments. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of, and...

  14. 78 FR 15894 - Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for Activities (Outside...

    Science.gov (United States)

    2013-03-13

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 117 Draft Qualitative Risk Assessment of Risk of... on a Farm; Availability; Reopening of the Comment Period AGENCY: Food and Drug Administration, HHS. ACTION: Notification; reopening of the comment period. SUMMARY: The Food and Drug Administration (FDA or...

  15. 78 FR 3824 - Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for Activities (Outside...

    Science.gov (United States)

    2013-01-16

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 117 Draft Qualitative Risk Assessment of Risk of... on a Farm; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notification; request for comments. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of, and requesting...

  16. 78 FR 24693 - Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for Activities (Outside...

    Science.gov (United States)

    2013-04-26

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 117 Draft Qualitative Risk Assessment of Risk of... on a Farm; Availability; Extension of the Comment Period AGENCY: Food and Drug Administration, HHS. ACTION: Notification; extension of comment period. SUMMARY: The Food and Drug Administration (FDA or we...

  17. 77 FR 9945 - Draft Guidance for Industry on Providing Submissions in Electronic Format-Standardized Study Data...

    Science.gov (United States)

    2012-02-21

    ... current thinking on the submission of study data in a standard electronic format. The draft guidance... current thinking on submitting standardized study data in electronic format. It does not create or confer... Electronic Format--Standardized Study Data; Availability AGENCY: Food and Drug Administration, HHS. ACTION...

  18. 77 FR 55195 - Notice of Public Meetings for the Draft Environmental Impact Statement for Naval Weapons Systems...

    Science.gov (United States)

    2012-09-07

    ... training of DoD personnel. With the filing of the Draft EIS, the DoN is initiating a 60-day public comment... action and the alternatives under consideration, and to provide an opportunity for the public to comment... Boardman; accommodate force structure changes; and provide enhancements to training facilities and...

  19. 76 FR 66734 - National Institute on Deafness and Other Communication Disorders Draft 2012-2016 Strategic Plan

    Science.gov (United States)

    2011-10-27

    ... Disorders Draft 2012-2016 Strategic Plan AGENCY: National Institute on Deafness and Other Communication...). ACTION: Notice. SUMMARY: The National Institute on Deafness and Other Communication Disorders (NIDCD... communication impairments or disorders; and supports efforts to create devices that substitute for lost and...

  20. 78 FR 68459 - Medical Device Development Tools; Draft Guidance for Industry, Tool Developers, and Food and Drug...

    Science.gov (United States)

    2013-11-14

    ... HUMAN SERVICES Food and Drug Administration Medical Device Development Tools; Draft Guidance for Industry, Tool Developers, and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the...

  1. 76 FR 51993 - Draft Guidance for Industry and Food and Drug Administration Staff on In Vitro Companion...

    Science.gov (United States)

    2011-08-19

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff on In Vitro Companion Diagnostic Devices; Extension of Comment Period AGENCY: Food and Drug Administration, HHS. ACTION: Notice; extension of comment period. SUMMARY: The Food and Drug Administration (FDA...

  2. 76 FR 19786 - Notice of Availability of the Draft Environmental Impact Statement for the Celatom Mine Expansion...

    Science.gov (United States)

    2011-04-08

    ... Bureau of Land Management Notice of Availability of the Draft Environmental Impact Statement for the Celatom Mine Expansion Project in Harney and Malheur Counties, OR AGENCY: Bureau of Land Management, Interior. ACTION: Notice of availability. SUMMARY: In accordance with the National Environmental Policy Act...

  3. 78 FR 14305 - Draft Guidance for Industry and Food and Drug Administration Staff; Types of Communication During...

    Science.gov (United States)

    2013-03-05

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is... Medical Device Submissions.'' The purpose of this guidance is to update the Agency's approach to...

  4. 76 FR 18552 - Seeking Public Comment on Two Draft Chapters of the National Health Security Strategy Biennial...

    Science.gov (United States)

    2011-04-04

    ... HUMAN SERVICES Office of the Secretary Seeking Public Comment on Two Draft Chapters of the National Health Security Strategy Biennial Implementation Plan AGENCY: Department of Health and Human Services, Office of the Secretary. ACTION: Notice. Authority: Public Health Service Act, 42 U.S.C. 300hh-1. SUMMARY...

  5. 78 FR 48172 - Minimizing Risk for Children's Toy Laser Products; Draft Guidance for Industry and Food and Drug...

    Science.gov (United States)

    2013-08-07

    ...] [FR Doc No: 2013-19018] DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-D-1092] Minimizing Risk for Children's Toy Laser Products; Draft Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION...

  6. 77 FR 51814 - Draft Guidance for Industry on Generic Drug User Fee Amendments of 2012: Questions and Answers...

    Science.gov (United States)

    2012-08-27

    ... Amendments of 2012: Questions and Answers; Availability AGENCY: Food and Drug Administration, HHS. ACTION... draft guidance for industry entitled ``Generic Drug User Fee Amendments of 2012: Questions and Answers... information annually to FDA. This guidance is intended to provide answers to common questions from the generic...

  7. 75 FR 57055 - Endangered and Threatened Wildlife and Plants; Draft Revised Recovery Plan for Utah Prairie Dog

    Science.gov (United States)

    2010-09-17

    ... for Utah Prairie Dog AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of document... availability of a draft revised recovery plan for the Utah prairie dog (Cynomys parvidens). This species is.... The Utah prairie dog (Cynomys parvidens), found only in southwestern and central Utah, was listed as...

  8. 75 FR 48973 - Draft Guidance for Industry: Prevention of Salmonella

    Science.gov (United States)

    2010-08-12

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Prevention of Salmonella... availability of a draft guidance entitled ``Prevention of Salmonella Enteritidis in Shell Eggs During... ``Prevention of Salmonella Enteritidis in Shell Eggs During Production, Storage, and Transportation'' (the...

  9. Indiana Bat (Myotis sodalis) Draft Recovery Plan: First Revision

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — U.S. Fish and Wildlife Service's Draft recovery plan for Indiana bats, a Federally endangered species. First revision. The purpose of this draft recovery plan is to...

  10. Draft national health policy 2015: A critical appraisal.

    Science.gov (United States)

    Ahmed, Faruque U

    2016-01-01

    Revising a health policy of any country is a periodic procedure dependent on the change of demographic profile, current health status of the population including epidemiological changes in disease prevalence pattern, and progress made under the earlier policies. Along with it, newer research revelation of the natural history of the existing and emerging health problems, availability of newer technology as well as changing sociopolitical commitment to improve the health status of the population are the driving forces in the change of policy. Draft National Health Policy (NHP) 2015 is an attempt for the same. A review of the draft has been undertaken. The chapter on introduction is crisp and clear. Situation analysis of the draft is sketchy and without any reference of sources. Shifting the health goal is without any basis, and the objectives defined for the policy change are incongruous with the introduction. A detailed description does not give a clear picture but rather confuses the reader as it talks of comprehensive universal health-care services to be provided with a holistic concept but maximum emphasis is made in the implementation of a national program. Private health-care services are an area to reckon but except for mere references on the involvement in private-public mode, nothing concrete is observed, especially in the primary care level. Involvement envisaged in the secondary and tertiary levels is nebulous. The implementation health insurance program as well as regulatory mechanISM with the existing is also not defined exclusively in the context of a newer health policy.

  11. Nanostructured materials for solid-state hydrogen storage: A review of the achievement of COST Action MP1103

    DEFF Research Database (Denmark)

    Callini, Elsa; Aguey-Zinsou, Kondo-Francois; Ahuja, Rajeev

    2016-01-01

    In the framework of the European Cooperation in Science and Technology (COST) Action MP1103 Nanostructured Materials for Solid-State Hydrogen Storage were synthesized, characterized and modeled. This Action dealt with the state of the art of energy storage and set up a competitive and coordinated...... the structure from bulk to thin film, nanoparticles and nanoconfined composites improved the hydrogen sorption properties and opened the perspective to new technological applications. Direct imaging of the hydrogenation reactions and in situ measurements under operando conditions have been carried out...

  12. Final Draft of RACER Audit

    Energy Technology Data Exchange (ETDEWEB)

    Paige, Karen Schultz [Los Alamos National Laboratory; Gomez, Penelope E. [Los Alamos National Laboratory

    2011-01-01

    This document describes the approach Waste and Environmental Services - Environmental Data and Analysis plans to take to resolve the issues presented in a recent audit of the WES-EDA Environmental Database relative to the RACER database. A majority of the issues discovered in the audit will be resolved in May 2011 when the WES-EDA Environmental Database, along with other LANL databases, are integrated and moved to a new vendor providing an Environmental Information Management (EIM) system that allows reporting capabilities for all users directly from the database. The EIM system will reside in a publicly accessible LANL cloud-based software system. When this transition occurs, the data quality, completeness, and access will change significantly. In the remainder of this document, this new structure will be referred to as the LANL Cloud System In general, our plan is to address the issues brought up in this audit in three ways: (1) Data quality issues such as units and detection status, which impinge upon data usability, will be resolved as soon possible so that data quality is maintained. (2) Issues requiring data cleanup, such as look up tables, legacy data, locations, codes, and significant data discrepancies, will be addressed as resources permit. (3) Issues associated with data feed problems will be eliminated by the LANL Cloud System, because there will be no data feed. As discussed in the paragraph above, in the future the data will reside in a publicly accessible system. Note that report writers may choose to convert, adapt, or simplify the information they receive officially through our data base, thereby introducing data discrepancies between the data base and the public report. It is not always possible to incorporate and/or correct these errors when they occur. Issues in the audit will be discussed in the order in which they are presented in the audit report. Clarifications will also be noted as the audit report was a draft document, at the time of this

  13. IRIS Toxicological Review of Thallium and Compounds (External Review Draft)

    Science.gov (United States)

    Thallium compounds are used in the semiconductor industry, the manufacture of optic lenses and low-melting glass, low-temperature thermometers, alloys, electronic devices, mercury lamps, fireworks, and imitation germs, and clinically as an imaging agent in the diagnosis of certai...

  14. IRIS Toxicological Review of Acrylonitrile (External Review Draft)

    Science.gov (United States)

    [UPDATE] New Schedule for IRIS Acrylonitrile Assessment In May 2012, EPA developed a new schedule for completing the IRIS acrylonitrile assessment. Acrylonitrile is primarily used in the manufacture of acrylic and modacrylic fibers, plastics, and nitrile rubbers. It ...

  15. The role of animal nutrition in designing optimal foods of animal origin as reviewed by the COST Action Feed for Health (FA0802

    Directory of Open Access Journals (Sweden)

    Pinotti, L.

    2014-01-01

    Full Text Available This review provides an overview of the main scientific outputs of a network (Action supported by the European Cooperation in Science and Technology (COST in the field of animal science, namely the COST Action Feed for Health (FA0802. The main aims of the COST Action Feed for Health (FA0802 were: to develop an integrated and collaborative network of research groups that focuses on the roles of feed and animal nutrition in improving animal wellbeing and also the quality, safety and wholesomeness of human foods of animal origin; to examine the consumer concerns and perceptions as regards livestock production systems. The COST Action Feed for Health has addressed these scientific topics during the last four years. From a practical point of view three main scientific fields of achievement can be identified: feed and animal nutrition; food of animal origin quality and functionality and consumers' perceptions. Finally, the present paper has the scope to provide new ideas and solutions to a range of issues associated with the modern livestock production system.

  16. First Draft of the Research Agenda

    DEFF Research Database (Denmark)

    Dahl, Hanne Marlene; Pieper, Michael; Fahnøe, Kristian

    ensuring the relevance of the suggested draft of a research agenda. The seven themes identified are: User-centeredness innovation in social services, Innovation in institutional development, Framing of social services in relation to innovation, The governance of innovation, Influence of regional and local......This report is a draft of a research agenda that the consortium INNOSERV has provided to the European Commission. It is the result of the work of researchers and insights provided by users, practitioners, experts and policy-makers involving around 20 examples of innovative practices from different...... parts of Europe (these examples have been transformed into visualizations). In the autumn of 2013, the draft will be presented to international experts and key national and European stakeholders, as input to the final research agenda. This research agenda will be presented to the European Commission...

  17. A systematic review of the anti-obesity and weight lowering effect of ginger (Zingiber officinale Roscoe) and its mechanisms of action.

    Science.gov (United States)

    Ebrahimzadeh Attari, Vahideh; Malek Mahdavi, Aida; Javadivala, Zeinab; Mahluji, Sepideh; Zununi Vahed, Sepideh; Ostadrahimi, Alireza

    2017-11-29

    Recently, the beneficial effects of ginger on obesity is taken into consideration. Albeit, it seems that the anti-obesity effect of ginger and its mechanism of action has not yet been reviewed. Therefore, the aim of this study was to systematically review the effect of Zingiber officinale Roscoe on obesity management. Databases including PubMed, Scopus, Google scholar, and Science Direct were searched from 1995 until May 2017 using the definitive keywords. Searching was limited to articles with English language. All of the relevant human and animal studies and also in vitro studies were included. Review articles, abstract in congress, and also other varieties of ginger were excluded. Eligibility of included articles were evaluated by 3 reviewers, which also extracted data. Articles were critically assessed individually for possible risk of bias. Twenty-seven articles (6 in vitro, 17 animal, and 4 human studies) were reviewed. Most of the experimental studies supported the weight lowering effect of ginger extract or powder in obese animal models, whereas the results of the available limited clinical studies showed no changes or slight changes of anthropometric measurements and body composition in subjects with obesity. Ginger could modulate obesity through various potential mechanisms including increasing thermogenesis, increasing lipolysis, suppression of lipogenesis, inhibition of intestinal fat absorption, and controlling appetite. This review article provides some convincing evidence to support the efficacy of ginger in obesity management and demonstrates the importance of future clinical trials. Copyright © 2017 John Wiley & Sons, Ltd.

  18. The Physics of Bump Drafting in Car Racing

    Science.gov (United States)

    Fiolhais, Miguel C. N.; Amor dos Santos, Susana

    2014-01-01

    The technique of bump drafting, also known as two-car drafting in motorsports, is analysed in the framework of Newtonian mechanics and simple aerodynamic drag forces. As an apparent unnatural effect that often pleases the enthusiasts of car racing, bump drafting provides a unique pedagogical opportunity for students to gain insights into the…

  19. Orientation, Sketching, Mechanical Drawing, Drafting--Basic: 9253.01.

    Science.gov (United States)

    Dade County Public Schools, Miami, FL.

    The course introduces the student to the drafting trade, freehand sketching, and basic mechanical drawing. The course has no prerequisites and will guide the student into drafting concepts and serve as a foundation for further study in vocational drafting. Requiring a total of 45 class hours, eight hours are utilized in orientation, 15 hours are…

  20. Critical review of the national action plans (NAcP) of the EU stress tests on nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Oda; Lorenz, Patricia

    2013-04-15

    , very much as the same reasons as TEPCO in Japan until Fukushima. The EU tried to respond to this ''new experience'' of Fukushima by conducting the stress tests and hoping that the results will lead to higher safety. This report investigated the result, the very concrete measures each nuclear safety authority will require its operators to implement and until which date. Transparency is another important tool to control nuclear risk; while ENSREG certainly recognizes this fact, not all national nuclear regulators and operators act accordingly to fulfil this need of higher transparency. It is evident that some countries treated this task rather as a formality or paperwork than a plant safety upgrade program. (The ENSREG peer review hopefully will insist on introducing additional measures to the national plans in those cases where the national regulator required less safety measures than the stress tests peer review recommended.) In general, there are different possibilities for operator and nuclear authority to remedy the shortcomings the stress tests revealed: - A quick response, but without any guarantee that the measures are sufficient (e.g. Wylfa, UK). - A comprehensive evaluation of possible hazards and protections measures, which will take more than ten years (e.g. Gravelines and Cattenom, France). - Business-as-usual, (e.g. Temelin, Czech Republic). The idea of the stress tests is more or less ignored. Instead the already ongoing measures are listed, major hardware improvement avoided. None of those possible variants increase the nuclear safety to an acceptable level. The very obvious solution - permanent shut down - needs to be considered and is in several cases the only safe option. This applies in particular to those plants where significant improvements cannot be achieved by the planned deployment of mobile equipment only or by having plants on the grid in the current status for many more years while evaluations and assessment are under

  1. Supplement to the Surplus Plutonium Disposition Draft Environmental Impact Statement

    Energy Technology Data Exchange (ETDEWEB)

    N/A

    1999-05-14

    services. The procurement process included the environmental review specified in DOE's NEPA regulations in 10 CFR 1021.216. The six reactors selected are Catawba Nuclear Station Units 1 and 2 in South Carolina McGuire Nuclear Station Units 1 and 2 in North Carolina, and North Anna Power Station Units 1 and 2 in Virginia. The Supplement describes the potential environmental impacts of using MOX fuel in these six specific reactors named in the DCS proposal as well as other program changes made since the SPD Draft EIS was published.

  2. 78 FR 17714 - Notice of Availability of the HiLine District Draft Resource Management Plan and Draft...

    Science.gov (United States)

    2013-03-22

    ... Bureau of Land Management Notice of Availability of the HiLine District Draft Resource Management Plan... Land Management (BLM) has prepared a Draft Resource Management Plan (RMP) and Draft Environmental... development. Other Restrictions: Avoidance area for rights-of-way, managed as Visual Resource Management (VRM...

  3. External Peer Review Team Report for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nye County, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Marutzky, Sam J. [Navarro-Intera, LLC (N-I), Las Vegas, NV (United States); Andrews, Robert [Navarro-Intera, LLC (N-I), Las Vegas, NV (United States)

    2015-01-01

    The peer review team commends the Navarro-Intera, LLC (N-I), team for its efforts in using limited data to model the fate of radionuclides in groundwater at Yucca Flat. Recognizing the key uncertainties and related recommendations discussed in Section 6.0 of this report, the peer review team has concluded that U.S. Department of Energy (DOE) is ready for a transition to model evaluation studies in the corrective action decision document (CADD)/corrective action plan (CAP) stage. The DOE, National Nuclear Security Administration Nevada Field Office (NNSA/NFO) clarified the charge to the peer review team in a letter dated October 9, 2014, from Bill R. Wilborn, NNSA/NFO Underground Test Area (UGTA) Activity Lead, to Sam J. Marutzky, N-I UGTA Project Manager: “The model and supporting information should be sufficiently complete that the key uncertainties can be adequately identified such that they can be addressed by appropriate model evaluation studies. The model evaluation studies may include data collection and model refinements conducted during the CADD/CAP stage. One major input to identifying ‘key uncertainties’ is the detailed peer review provided by independent qualified peers.” The key uncertainties that the peer review team recognized and potential concerns associated with each are outlined in Section 6.0, along with recommendations corresponding to each uncertainty. The uncertainties, concerns, and recommendations are summarized in Table ES-1. The number associated with each concern refers to the section in this report where the concern is discussed in detail.

  4. Twenty-Five Years of Ecological Recovery of East Fork Poplar Creek: Review of Environmental Problems and Remedial Actions

    Science.gov (United States)

    Loar, James M.; Stewart, Arthur J.; Smith, John G.

    2011-06-01

    In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Department of Energy's Y-12 National Security Complex (Y-12 Complex) in Oak Ridge, Tennessee, USA, allowing discharge of effluents to East Fork Poplar Creek (EFPC). The effluents ranged from large volumes of chlorinated once-through cooling water and cooling tower blow-down to smaller discharges of treated and untreated process wastewaters, which contained a mixture of heavy metals, organics, and nutrients, especially nitrates. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to meet two major objectives: demonstrate that the established effluent limitations were protecting the classified uses of EFPC, and document the ecological effects resulting from implementing a Water Pollution Control Program at the Y-12 Complex. The second objective is the primary focus of the other papers in this special series. This paper provides a history of pollution and the remedial actions that were implemented; describes the geographic setting of the study area; and characterizes the physicochemical attributes of the sampling sites, including changes in stream flow and temperature that occurred during implementation of the BMAP. Most of the actions taken under the Water Pollution Control Program were completed between 1986 and 1998, with as many as four years elapsing between some of the most significant actions. The Water Pollution Control Program included constructing nine new wastewater treatment facilities and implementation of several other pollution-reducing measures, such as a best management practices plan; area-source pollution control management; and various spill-prevention projects. Many of the major actions had readily discernable effects on the chemical and physical conditions of EFPC. As controls on effluents entering the stream were implemented, pollutant concentrations generally declined and, at least initially, the volume of water

  5. On the origins of human handedness and language: a comparative review of hand preferences for bimanual coordinated actions and gestural communication in nonhuman primates.

    Science.gov (United States)

    Meguerditchian, Adrien; Vauclair, Jacques; Hopkins, William D

    2013-09-01

    Within the evolutionary framework about the origin of human handedness and hemispheric specialization for language, the question of expression of population-level manual biases in nonhuman primates and their potential continuities with humans remains controversial. Nevertheless, there is a growing body of evidence showing consistent population-level handedness particularly for complex manual behaviors in both monkeys and apes. In the present article, within a large comparative approach among primates, we will review our contribution to the field and the handedness literature related to two particular sophisticated manual behaviors regarding their potential and specific implications for the origins of hemispheric specialization in humans: bimanual coordinated actions and gestural communication. Whereas bimanual coordinated actions seem to elicit predominance of left-handedness in arboreal primates and of right-handedness in terrestrial primates, all handedness studies that have investigated gestural communication in several primate species have reported stronger degree of population-level right-handedness compared to noncommunicative actions. Communicative gestures and bimanual actions seem to affect differently manual asymmetries in both human and nonhuman primates and to be related to different lateralized brain substrates. We will discuss (1) how the data of hand preferences for bimanual coordinated actions highlight the role of ecological factors in the evolution of handedness and provide additional support the postural origin theory of handedness proposed by MacNeilage [MacNeilage [2007]. Present status of the postural origins theory. In W. D. Hopkins (Ed.), The evolution of hemispheric specialization in primates (pp. 59-91). London: Elsevier/Academic Press] and (2) the hypothesis that the emergence of gestural communication might have affected lateralization in our ancestor and may constitute the precursors of the hemispheric specialization for language.

  6. Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: a review of the protective action of melatonin

    Energy Technology Data Exchange (ETDEWEB)

    Gultekin, Fatih; Hicyilmaz, Hicran [Suleyman Demirel University, School of Medicine, Department of Biochemistry, Isparta (Turkey)

    2007-10-15

    This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage. (orig.)

  7. Review of decision methodologies for evaluating regulatory actions affecting public health and safety. [Nuclear industry site selection

    Energy Technology Data Exchange (ETDEWEB)

    Hendrickson, P.L.; McDonald, C.L.; Schilling, A.H.

    1976-12-01

    This report examines several aspects of the problems and choices facing the governmental decision maker who must take regulatory actions with multiple decision objectives and attributes. Particular attention is given to the problems facing the U.S. Nuclear Regulatory Commission (NRC) and to the decision attribute of chief concern to NRC, the protection of human health and safety, with emphasis on nuclear power plants. The study was undertaken to provide background information for NRC to use in refining its process of value/impact assessment of proposed regulatory actions. The principal conclusion is that approaches to rationally consider the value and impact of proposed regulatory actions are available. These approaches can potentially improve the decision-making process and enable the agency to better explain and defend its decisions. They also permit consistent examination of the impacts, effects of uncertainty and sensitivity to various assumptions of the alternatives being considered. Finally, these approaches can help to assure that affected parties are heard and that technical information is used appropriately and to the extent possible. The principal aspects of the regulatory decision problem covered in the report are: the legal setting for regulatory decisions which affect human health and safety, elements of the decision-making process, conceptual approaches to decision making, current approaches to decision making in several Federal agencies, and the determination of acceptable risk levels.

  8. 76 FR 21907 - Draft Action Plan-A Public Health Action Plan To Combat Antimicrobial Resistance

    Science.gov (United States)

    2011-04-19

    ...., Eastern Daylight Time, at 1600 Clifton Road, NE., Atlanta, Georgia 30333. Please call ahead to (404) 639... parasites) and settings (human medicine, veterinary medicine, agriculture, animal production, and others...

  9. 76 FR 14402 - Draft Action Plan-A Public Health Action Plan To Combat Antimicrobial Resistance

    Science.gov (United States)

    2011-03-16

    ..., from 9 a.m. until 5 p.m., Eastern Daylight Time, at 1600 Clifton Road, NE., Atlanta, Georgia 30333..., fungi, and parasites) and settings (human medicine, veterinary medicine, agriculture, animal production...

  10. On the Drafting of Confidentiality Agreements

    DEFF Research Database (Denmark)

    Drewsen, Merete; Lando, Henrik; Cummins, Tim

    2006-01-01

    IACCM (International Association for Contract and Commercial Management) has initiated. The main theoretical aspect of the article concerns the application of the value maximization principle (the Coase theorem) to the drafting of confidentiality agreements. While the article is not theoretical, its...

  11. Architectural Drafting. Curriculum Development. Bulletin 1779.

    Science.gov (United States)

    Eppler, Thomas

    This teaching guide is designed to aid high school vocational education teachers in teaching a course in architectural drafting for students who plan to become architects, interior designers and decorators, architectural draftspersons, landscape engineers, building contractors, building estimators, real estate persons or appraisers, and others.…

  12. An Analysis of the Drafting Occupation.

    Science.gov (United States)

    Plescia, George W.; And Others

    The general purpose of the occupational analysis is to provide workable, basic information dealing with the many and varied duties performed in the drafting occupation. The document opens with a brief introduction followed by a job description. The bulk of the document is presented in table form. Twelve duties are broken down into a number of…

  13. Draft SEI Program Plans: 1994-1998

    Science.gov (United States)

    1993-08-01

    SEO Program Plans: 1994-1986 chapi 3 redw," rOOM Res One-Yew Plan Core Fund Ac Risk Program Project Documents Historles Publication. Por Manager’s...page 55 CMU/SEI-93-SR-19 121 Chapis 4 Technoloy Traraition Draft SOI Program Plan: 1994-1ION Products and SUvic Sunmfry of SEI Product Plan Pow"da

  14. Draft Genome Sequence of Mycobacterium abscessus Bamboo

    Science.gov (United States)

    Yee, Michelle; Klinzing, David; Wei, Jun-Rong; Gengenbacher, Martin; Rubin, Eric J.

    2017-01-01

    ABSTRACT Mycobacterium abscessus, an intrinsically multidrug-resistant pathogen, causes chronic incurable lung disease. New drugs for this emerging pathogen represent an urgent unmet medical need. Here, we report a draft genome sequence of M. abscessus Bamboo, a clinical isolate used as a screening strain for drug discovery. PMID:28522728

  15. Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter--a review of current understanding of its mechanism of action.

    Science.gov (United States)

    Zhong, Huailing; Haddjeri, Nasser; Sánchez, Connie

    2012-01-01

    Escitalopram is a widely used antidepressant for the treatment of patients with major depression. It is the pure S-enantiomer of racemic citalopram. Several clinical trials and meta-analyses indicate that escitalopram is quantitatively more efficacious than many other antidepressants with a faster onset of action. This paper reviews current knowledge about the mechanism of action of escitalopram. The primary target for escitalopram is the serotonin transporter (SERT), which is responsible for serotonin (or 5-hydroxytryptamine [5-HT]) reuptake at the terminals and cell bodies of serotonergic neurons. Escitalopram and selective serotonin reuptake inhibitors bind with high affinity to the 5-HT binding site (orthosteric site) on the transporter. This leads to antidepressant effects by increasing extracellular 5-HT levels which enhance 5-HT neurotransmission. SERT also has one or more allosteric sites, binding to which modulates activity at the orthosteric binding site but does not directly affect 5-HT reuptake by the transporter. In vitro studies have shown that through allosteric binding, escitalopram decreases its own dissociation rate from the orthosteric site on the SERT. R-citalopram, the nontherapeutic enantiomer in citalopram, is also an allosteric modulator of SERT but can inhibit the actions of escitalopram by interfering negatively with its binding. Both nonclinical studies and some clinical investigations have demonstrated the cellular, neurochemical, neuroadaptive, and neuroplastic changes induced by escitalopram with acute and chronic administration. The findings from binding, neurochemical, and neurophysiological studies may provide a mechanistic rationale for the clinical difference observed with escitalopram compared to other antidepressant therapies.

  16. The effects of policy actions to improve population dietary patterns and prevent diet-related non-communicable diseases: scoping review.

    Science.gov (United States)

    Hyseni, L; Atkinson, M; Bromley, H; Orton, L; Lloyd-Williams, F; McGill, R; Capewell, S

    2017-06-01

    Poor diet generates a bigger non-communicable disease (NCD) burden than tobacco, alcohol and physical inactivity combined. We reviewed the potential effectiveness of policy actions to improve healthy food consumption and thus prevent NCDs. This scoping review focused on systematic and non-systematic reviews and categorised data using a seven-part framework: price, promotion, provision, composition, labelling, supply chain, trade/investment and multi-component interventions. We screened 1805 candidate publications and included 58 systematic and non-systematic reviews. Multi-component and price interventions appeared consistently powerful in improving healthy eating. Reformulation to reduce industrial trans fat intake also seemed very effective. Evidence on food supply chain, trade and investment studies was limited and merits further research. Food labelling and restrictions on provision or marketing of unhealthy foods were generally less effective with uncertain sustainability. Increasingly strong evidence is highlighting potentially powerful policies to improve diet and thus prevent NCDs, notably multi-component interventions, taxes, subsidies, elimination and perhaps trade agreements. The implications for policy makers are becoming clearer.

  17. Action semantics modulate action prediction.

    Science.gov (United States)

    Springer, Anne; Prinz, Wolfgang

    2010-11-01

    Previous studies have demonstrated that action prediction involves an internal action simulation that runs time-locked to the real action. The present study replicates and extends these findings by indicating a real-time simulation process (Graf et al., 2007), which can be differentiated from a similarity-based evaluation of internal action representations. Moreover, results showed that action semantics modulate action prediction accuracy. The semantic effect was specified by the processing of action verbs and concrete nouns (Experiment 1) and, more specifically, by the dynamics described by action verbs (Experiment 2) and the speed described by the verbs (e.g., "to catch" vs. "to grasp" vs. "to stretch"; Experiment 3). These results propose a linkage between action simulation and action semantics as two yet unrelated domains, a view that coincides with a recent notion of a close link between motor processes and the understanding of action language.

  18. Geothermal Program Review XII: proceedings. Geothermal Energy and the President's Climate Change Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-12-31

    Geothermal Program Review XII, sponsored by the Geothermal Division of US Department of Energy, was held April 25--28, 1994, in San Francisco, California. This annual conference is designed to promote effective technology transfer by bringing together DOE-sponsored researchers; utility representatives; geothermal energy developers; suppliers of geothermal goods and services; representatives from federal, state, and local agencies; and others with an interest in geothermal energy. In-depth reviews of the latest technological advancements and research results are presented during the conference with emphasis on those topics considered to have the greatest potential to impact the near-term commercial development of geothermal energy.

  19. Public policy, health system, and community actions against illness as platforms for response to NCDs in Tanzania : a narrative review

    NARCIS (Netherlands)

    Metta, Emmy; Msambichaka, Beverly; Mwangome, Mary; Nyato, Daniel J; Dieleman, Marjolein; Haisma, Hinke; Klatser, P.R.; Geubbels, Eveline

    2014-01-01

    BACKGROUND: Most low- and middle- income countries are facing a rise of the burden of non-communicable diseases (NCDs) alongside the persistent burden of infectious diseases. This narrative review aims to provide an inventory of how the existing policy environment, health system, and communities are

  20. A systematic review on micronutrient intake adequacy in adult minority populations residing in Europe: The need for action

    NARCIS (Netherlands)

    Ngo, J.; Roman-Vinas, B.; Ribas-Barba, L.; Golsorkhi, M.; Wharthon Medina, M.; Bekkering, G.E.; Cavelaars, A.J.E.M.; Groot, de C.P.G.M.

    2014-01-01

    This systematic review evaluated micronutrient intake inadequacy of ten micronutrients for adult ethnic minority populations residing in Europe. Pubmed was searched for studies, related references were checked and experts consulted. Ten studies were identified and six were included in the final

  1. IMPLICATIONS OF THE CURRENT EXPOSURE DRAFT ON AUDIT REPORTING

    Directory of Open Access Journals (Sweden)

    George Silviu CORDOȘ

    2015-04-01

    Full Text Available The regulatory changes come as a response to perceived deficiencies in the postfinancial crisis, and their goal is to improve users' perception of the usefulness and quality of the audit report. The article approaches the subject of these proposals to revise the standards and their implications for the audit report. The article is divided into five parts: the first part the authors present a brief introduction to the subject matter; the second part presents the research methodology; the third part the authors present a review of the literature research; the fourth section presents an analysis of the responses of EU respondents to the Exposure Draft issued by the IAASB in July 2013 and the last part the authors present research findings, limitations and perspectives.

  2. Leadership Training for Collaboration. Draft.

    Science.gov (United States)

    Kagan, Sharon L.

    Based in part on a 1992 study of 72 United States early care collaborations and leaders, this paper explores conventional understandings of leadership, reviews the leadership literature, and goes on to compare and discuss collaborative leadership in detail. The paper notes that collaborative leadership stresses the relatedness of systems wherein…

  3. Repetitive compound muscle action potentials in electrophysiological diagnosis of congenital myasthenic syndromes: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Kumar R

    2010-01-01

    Full Text Available Congenital myasthenic syndromes (CMSs are a heterogeneous group of disorders, characterized by dysfunction of neuromuscular junction (NMJ transmission. These syndromes are genetically inherited and are present since birth. Some have characteristic clinical or electrodiagnostic features but in many cases determination of the specific form requires genetic studies or specialized morphological and electrophysiological studies on muscle tissue. We report a case of a 4-year-old boy with progressive ptosis and limitation of ocular movements who was diagnosed as slow-channel CMS based on the characteristic electrodiagnostic features. Repetitive compound muscle action potentials (R-CMAPs were recorded after single nerve stimulus, with decremental response after repetitive trains performed at 3 Hz. CMSs are at times clinically difficult to distinguish from acquired myasthenia. The characteristic clinical and electrodiagnostic features help in the diagnosis and enable rational therapy. In this article we discuss the characteristics of synaptic R-CMAPs.

  4. An Interim Report on NASA's Draft Space Technology Roadmaps

    Science.gov (United States)

    2011-01-01

    NASA has developed a set of 14 draft roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist (OCT). Each of these roadmaps focuses on a particular technology area (TA). The roadmaps are intended to foster the development of advanced technologies and concepts that address NASA's needs and contribute to other aerospace and national needs. OCT requested that the National Research Council conduct a study to review the draft roadmaps, gather and assess relevant community input, and make recommendations and suggest priorities to inform NASA's decisions as it finalizes its roadmaps. The statement of task states that "based on the results of the community input and its own deliberations, the steering committee will prepare a brief interim report that addresses high-level issues associated with the roadmaps, such as the advisability of modifying the number or technical focus of the draft NASA roadmaps." This interim report, which does not include formal recommendations, addresses that one element of the study charge. NASA requested this interim report so that it would have the opportunity to make an early start in modifying the draft roadmaps based on feedback from the panels and steering committee. The final report will address all other tasks in the statement of task. In particular, the final report will include a prioritization of technologies, will describe in detail the prioritization process and criteria, and will include specific recommendations on a variety of topics, including many of the topics mentioned in this interim report. In developing both this interim report and the final report to come, the steering committee draws on the work of six study panels organized by technical area, loosely following the organization of the 14 roadmaps, as follows: A Panel 1: Propulsion and Power TA01 Launch Propulsion Systems TA02 In-Space Propulsion Technologies TA03 Space Power and Energy Storage Systems TA13

  5. 78 FR 51709 - Notice of Availability of Draft Environmental Assessment on the Effects of Issuing an Incidental...

    Science.gov (United States)

    2013-08-21

    ... Environmental Assessment on the Effects of Issuing an Incidental Take Permit No. 18102 AGENCY: National Marine... the availability of the ``Draft Environmental Assessment (EA) on the Effects of Issuing an Incidental... the Internet at www.nmfs.noaa.gov/pr/permits/esa_review.htm . DATES: Written comments must be received...

  6. 76 FR 72006 - Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon...

    Science.gov (United States)

    2011-11-21

    ... COMMISSION Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon... Recovery Facility Surveys of Radon and Radon Progeny in Air and Demonstrations of Compliance with 10 CFR 20... that existing guidance does not sufficiently detail how the NRC staff reviews surveys of radon and...

  7. 76 FR 55728 - Notice of the Extension of the Comment Period for the Draft Environmental Impact Report...

    Science.gov (United States)

    2011-09-08

    ... High-Speed Rail Authority (Authority) is the lead state agency for the environmental review process..., electric powered, passenger rail, high-speed railroad along a 114-mile corridor between Fresno and.... ADDRESSES: Written comments on the Draft EIR/EIS should be sent to the California High-Speed Rail Authority...

  8. Workshop to Obtain Input on Draft Materials for the Integrated Science Assessment (ISA) for Sulfur Oxides (SOx): Health Criteria

    Science.gov (United States)

    As part of the review of the air quality criteria for sulfur oxides (SOX) and primary (health-based) National Ambient Air Quality Standards (NAAQS) for sulfur dioxide (SO2), EPA is announcing a teleconference workshop to evaluate preliminary draft materials ...

  9. Draft scientific concept of the research project

    Directory of Open Access Journals (Sweden)

    Bazić Miljojko

    2015-01-01

    Full Text Available Every scientific research involves the systematic study of phenomena and processes that occur in nature and society. Such a systematic study is not possible without the use of objective instruments for collecting, processing and analyzing data and without the application of scientific methods for drawing conclusions, propriety and legality of the researching object properties. That is why all systematic scientific studies require advance planning and design, and that in one scientific, operational and planning document, called the research project is devised a way of acquiring scientific knowledge, which will represent a logical, structured unit, rational and purposeful, mutually compatible and functionally related attitudes, judgments and conclusions of the research subject. The general methodology of scientific research has defined the scientific standards, rules and procedures by which a scientific research project is created. The project of scientific research has a standard structure element of the project which consists of: a draft scientific concept; b research plans; iv research instruments, including a plan of arrangement and data processing. Since numerous difficulties encountered by young researchers in establishing draft scientific ideas in theirs Master's and Doctoral Theses in the last edition of the Megatrend journal, we have offered to scientific and professional public the first three elements of the scientific concept structure draft of the research project: formulation of the research problem, determination of research subject and the formulation of scientific and social research objectives. In this edition of the Megatrend journal, according to the strict requirements of the general methodology of science and special methodology of science, scientific and professional community, we present the following three elements of the draft of the scientific concept of research: a hypothetical framework of the research, the method of

  10. Review of USGS Open-file Report 95-525 ("Cartographic and digital standard for geologic map information") and plans for development of Federal draft standards for geologic map information

    Science.gov (United States)

    Soller, David R.

    1996-01-01

    This report summarizes a technical review of USGS Open-File Report 95-525, 'Cartographic and Digital Standard for Geologic Map Information' and OFR 95-526 (diskettes containing digital representations of the standard symbols). If you are considering the purchase or use of those documents, you should read this report first. For some purposes, OFR 95-525 (the printed document) will prove to be an excellent resource. However, technical review identified significant problems with the two documents that will be addressed by various Federal and State committees composed of geologists and cartographers, as noted below. Therefore, the 2-year review period noted in OFR 95-525 is no longer applicable. Until those problems are resolved and formal standards are issued, you may consult the following World-Wide Web (WWW) site which contains information about development of geologic map standards: URL: http://ncgmp.usgs.gov/ngmdbproject/home.html

  11. Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences.

    Science.gov (United States)

    Villa, Julia Khéde Dourado; Diaz, Marisa Alves Nogueira; Pizziolo, Virgínia Ramos; Martino, Hércia Stampini Duarte

    2017-12-12

    Osteoporosis is a public health concern associated with an increased risk of bone fractures and vascular calcification. Vitamin K presents unique benefits on these issues, although understudied. The two main forms of vitamin K are phylloquinone (vitamin K1) and menaquinone (vitamin K2). In this study, it was especially investigated the action of vitamin K2 in bones and vessels. Vitamin K2 has shown to stimulate bone formation by promoting osteoblast differentiation and carboxylation of osteocalcin, and increasing alkaline phosphatase, insulin-like growth factor-1, growth differentiation factor-15, and stanniocalcin 2 levels. Furthermore, vitamin K2 reduces the pro-apoptotic proteins Fas and Bax in osteoblasts, and decreases osteoclast differentiation by increasing osteoprotegerin and reducing the receptor activator of nuclear factor kappa-B ligand. In blood vessels, vitamin K2 reduces the formation of hydroxyapatite, through the carboxylation of matrix Gla protein and Gla rich protein, inhibits the apoptosis of vascular smooth muscle cells, by increasing growth arrest-specific gene 6, and reduces the transdifferentiation of vascular smooth muscle cells to osteoblasts. The commonly used dosage of vitamin K2 in human studies is 45 mg/day and its application can be an interesting strategy in benefitting bone and vascular health, especially to osteoporotic post-menopausal women.

  12. 76 FR 36534 - Toxicological Review of Methanol (Non-Cancer): In Support of Summary Information on the...

    Science.gov (United States)

    2011-06-22

    ... AGENCY Toxicological Review of Methanol (Non-Cancer): In Support of Summary Information on the Integrated... external peer review draft human health assessment titled ``Toxicological Review of Methanol (Non- Cancer... to the draft Toxicological Review of Methanol (Non-Cancer) and announcing a 14-day public comment...

  13. IRIS Toxicological Review of Trichloroacetic Acid (TCA) ...

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review of Trichloroacetic Acid (TCA), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid.

  14. Yet another guideline? The UNESCO draft declaration.

    Science.gov (United States)

    Macklin, Ruth

    2005-09-01

    Some people might argue that there are already too many different documents, guidelines, and regulations in bioethics. Some overlap with one another, some are advisory and lack legal force, others are legally binding in countries, and still others are directed at narrow topics within bioethics, such as HIV/AIDS and human genetics. As the latest document to enter the fray, the UNESCO Declaration has the widest scope of any previous document. It embraces not only research involving human beings, but addresses broader concerns in medicine and healthcare. The UNESCO draft declaration has some minor weaknesses, but on the whole, the strengths outweigh the weaknesses. One weakness is that some items in the draft are stated in a way that is too restrictive, thereby appearing to rule out legitimate activities. A strength of the Declaration is that it is relatively brief, yet at the same time contains sufficient detail to make it something more than a rehearsal of mere pieties. As the most recent of the numerous bioethics and human rights documents, the UNESCO draft draws on many of the earlier documents and also includes some of the most recent thinking about ethical norms and obligations. Perhaps its greatest strength lies not in details of the principles or their implementation, but rather in its stature as an international declaration issued by a United Nations organization.

  15. There or not there? A multidisciplinary review and research agenda on the impact of transparent barriers on human perception, action, and social behavior.

    Science.gov (United States)

    Marquardt, Gesine; Cross, Emily S; de Sousa, Alexandra A; Edelstein, Eve; Farnè, Alessandro; Leszczynski, Marcin; Patterson, Miles; Quadflieg, Susanne

    2015-01-01

    Through advances in production and treatment technologies, transparent glass has become an increasingly versatile material and a global hallmark of modern architecture. In the shape of invisible barriers, it defines spaces while simultaneously shaping their lighting, noise, and climate conditions. Despite these unique architectural qualities, little is known regarding the human experience with glass barriers. Is a material that has been described as being simultaneously there and not there from an architectural perspective, actually there and/or not there from perceptual, behavioral, and social points of view? In this article, we review systematic observations and experimental studies that explore the impact of transparent barriers on human cognition and action. In doing so, the importance of empirical and multidisciplinary approaches to inform the use of glass in contemporary architecture is highlighted and key questions for future inquiry are identified.

  16. There or not there? A multidisciplinary review and research agenda on the impact of transparent barriers on human perception, action, and social behavior

    Science.gov (United States)

    Marquardt, Gesine; Cross, Emily S.; de Sousa, Alexandra A.; Edelstein, Eve; Farnè, Alessandro; Leszczynski, Marcin; Patterson, Miles; Quadflieg, Susanne

    2015-01-01

    Through advances in production and treatment technologies, transparent glass has become an increasingly versatile material and a global hallmark of modern architecture. In the shape of invisible barriers, it defines spaces while simultaneously shaping their lighting, noise, and climate conditions. Despite these unique architectural qualities, little is known regarding the human experience with glass barriers. Is a material that has been described as being simultaneously there and not there from an architectural perspective, actually there and/or not there from perceptual, behavioral, and social points of view? In this article, we review systematic observations and experimental studies that explore the impact of transparent barriers on human cognition and action. In doing so, the importance of empirical and multidisciplinary approaches to inform the use of glass in contemporary architecture is highlighted and key questions for future inquiry are identified. PMID:26441756

  17. The Anti-Inflammatory and Antibacterial Action of Nanocrystalline Silver and Manuka Honey on the Molecular Alternation of Diabetic Foot Ulcer: A Comprehensive Literature Review.

    Science.gov (United States)

    Tsang, Ka-Kit; Kwong, Enid Wai-Yung; Woo, Kevin Y; To, Tony Shing-Shun; Chung, Joanne Wai-Yee; Wong, Thomas Kwok-Shing

    2015-01-01

    Honey and silver have been used since ancient times for treating wounds. Their widespread clinical application has attracted attention in light of the increasing prevalence of antibiotic-resistant bacteria. While there have been a number of studies exploring the anti-inflammatory and antibacterial effects of manuka honey and nanocrystalline silver, their advantages and limitations with regard to the treatment of chronic wounds remain a subject of debate. The aim of this paper is to examine the evidence on the use of nanocrystalline silver and manuka honey for treating diabetic foot ulcers through a critical and comprehensive review of in vitro studies, animal studies, and in vivo studies. The findings from the in vitro and animal studies suggest that both agents have effective antibacterial actions. Their anti-inflammatory action and related impact on wound healing are unclear. Besides, there is no evidence to suggest that any topical agent is more effective for use in treating diabetic foot ulcer. Overall, high-quality, clinical human studies supported by findings from the molecular science on the use of manuka honey or nanocrystalline silver are lacking. There is a need for rigorously designed human clinical studies on the subject to fill this knowledge gap and guide clinical practice.

  18. The Anti-Inflammatory and Antibacterial Action of Nanocrystalline Silver and Manuka Honey on the Molecular Alternation of Diabetic Foot Ulcer: A Comprehensive Literature Review

    Directory of Open Access Journals (Sweden)

    Ka-Kit Tsang

    2015-01-01

    Full Text Available Honey and silver have been used since ancient times for treating wounds. Their widespread clinical application has attracted attention in light of the increasing prevalence of antibiotic-resistant bacteria. While there have been a number of studies exploring the anti-inflammatory and antibacterial effects of manuka honey and nanocrystalline silver, their advantages and limitations with regard to the treatment of chronic wounds remain a subject of debate. The aim of this paper is to examine the evidence on the use of nanocrystalline silver and manuka honey for treating diabetic foot ulcers through a critical and comprehensive review of in vitro studies, animal studies, and in vivo studies. The findings from the in vitro and animal studies suggest that both agents have effective antibacterial actions. Their anti-inflammatory action and related impact on wound healing are unclear. Besides, there is no evidence to suggest that any topical agent is more effective for use in treating diabetic foot ulcer. Overall, high-quality, clinical human studies supported by findings from the molecular science on the use of manuka honey or nanocrystalline silver are lacking. There is a need for rigorously designed human clinical studies on the subject to fill this knowledge gap and guide clinical practice.

  19. On Research in Action and Action in Research

    OpenAIRE

    Blichfeldt, Bodil Stilling; Andersen, Jesper Rank

    2005-01-01

    A unique (and challenging) characteristic of social sciences is that these sci-ences are multi-paradigmatic and adhere to a wide range of research strategies. One research strategy that social scientists can choose to rely on is action re-search. However, action research qualifies as a research strategy much criticised for not being subject to scientific rigor. Drawing on an extensive review of the literature on action research, this paper discusses what action research is (not) and what it c...

  20. Contributions from the South African Society of Psychiatrists (SASOP to the National Mental Health Action Plan

    Directory of Open Access Journals (Sweden)

    Albert Bernard Janse van Rensburg

    2013-11-01

    Full Text Available The national Mental Health Action Plan (MHAP flowed from the Ekurhuleni Declaration, adopted at the National Mental Health Summit (NMHS in April 2012. The final draft of the MHAP included eight national objectives, with key activities which were believed to be ‘catalytic.’ These objectives include: district-based mental health service; institutional capacity; surveillance, research and innovation; infrastructure and capacity; mental health technology, equipment and medicines; inter-sectoral collaboration; human resources; and advocacy, mental health promotion and prevention of illness. A representative group of regional State Employed Special Interest Group (SESIG delegates met during April 2013, to: operationalise the 12 South African Society of Psychiatrists (SASOP/SESIG position statements of the previous year; review SASOP’s position statements in the context of the proposed national MHAP; and to identify SASOP’s role and responsibilities accordingly. This paper describes the contextual events in the drafting of the MHAP, as well as the appraisal of the MHAP during the 2013 SASOP/SESIG meeting, and SASOP’S envisaged role and responsibilities according to the national MHAP.