WorldWideScience

Sample records for action review draft

  1. A national program for energy-efficient mortgages and home energy rating systems: A blueprint for action. Review draft

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    This Review Draft reports findings and recommendations of the National Collaborative on Home Energy Rating Systems and Mortgage Incentives for Energy Efficiency. The US Department of Energy, in cooperation with the US Department of Housing and Urban Development, formed this National Collaborative as a National Energy Strategy initiative. Participating in the Collaborative were representatives of the primary and secondary mortgage markets, builder and remodeler organizations, real estate and appraiser associations, the home energy rating system industry, utility associations, consumer and public interest groups, state and local government interest groups, and environmental organizations. The Collaborative`s purpose was to develop a voluntary national program encouraging energy efficiency in homes through mortgage incentives linked to home energy ratings.

  2. 75 FR 27838 - Notice of Availability of Draft NUREG-1800, Revision 2; “Standard Review Plan for Review of...

    Science.gov (United States)

    2010-05-18

    ... NUREG-1800, Revision 2; ``Standard Review Plan for Review of License Renewal Applications for Nuclear Power Plants'' and Draft NUREG-1801, Revision 2; ``Generic Aging Lessons Learned (GALL) Report'' AGENCY: Nuclear Regulatory Commission (NRC). ACTION: Issuance of draft NUREG-1800, ``Standard Review Plan...

  3. IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)

    Science.gov (United States)

    On May 3, 2013, the Toxicological Review of Methanol (noncancer) (Revised External Review Draft) was posted for public review and comment. Subsequently, the draft Toxicological Review, Appendices, and draft IRIS Summary were reviewed internally by EPA and by other federal agenci...

  4. 77 FR 28883 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    Science.gov (United States)

    2012-05-16

    ... HUMAN SERVICES Centers for Disease Control and Prevention Draft Public Health Action Plan--A National Public Health Action Plan for the Detection, Prevention, and Management of Infertility AGENCY: Centers... requesting public comment on the draft National Public Health Action Plan for the Detection, Prevention,...

  5. 77 FR 38296 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    Science.gov (United States)

    2012-06-27

    ... HUMAN SERVICES Centers for Disease Control and Prevention Draft Public Health Action Plan--A National Public Health Action Plan for the Detection, Prevention, and Management of Infertility AGENCY: Centers... Federal Register requesting public comment on the draft National Public Health Action Plan for...

  6. 75 FR 18205 - Notice of Peer Review Meeting for the External Peer Review Drafts of Two Documents on Using...

    Science.gov (United States)

    2010-04-09

    ... AGENCY Notice of Peer Review Meeting for the External Peer Review Drafts of Two Documents on Using... Agency (EPA). ACTION: Notice of Peer Review Meeting with Opportunity for Public Comment. SUMMARY: EPA is announcing that Eastern Research Group, Inc. (ERG), an EPA contractor for external scientific peer...

  7. IRIS Toxicological Review of Halogenated Platinum Salts and Platinum Compounds (External Review Draft)

    Science.gov (United States)

    EPA released the draft toxicological review for public comment under the Integrated Risk Information System (IRIS) Program. The original draft assessment (January 2009) has been archived but is available on this web page for the sake of transparency.

  8. 78 FR 65980 - Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation...

    Science.gov (United States)

    2013-11-04

    ... AGENCY Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation... have produced draft Climate Change Adaptation Implementation Plans (``Implementation Plans'') that... health and the environment. As EPA articulated in its draft Agency Climate Change Adaptation Plan,...

  9. 75 FR 1790 - Draft Guidance for Institutional Review Boards, Clinical Investigators, and Sponsors: IRB...

    Science.gov (United States)

    2010-01-13

    ... of February 3, 2006 (71 FR 5861), which describes FDA's intention to update the process for... HUMAN SERVICES Food and Drug Administration Draft Guidance for Institutional Review Boards, Clinical...: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  10. IRIS Toxicological Review for Acrylamide (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review for Acrylamide, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process<...

  11. IRIS TOXICOLOGICAL REVIEW OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE) (INTERAGENCY SCIENCE DISCUSSION DRAFT)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review of Tetrachloroethylene (Perchloroethylene), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment...

  12. IRIS Toxicological Review for Acrylamide (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review for Acrylamide, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process<...

  13. A review of dynamics modelling of friction draft gear

    Science.gov (United States)

    Wu, Qing; Cole, Colin; Luo, Shihui; Spiryagin, Maksym

    2014-06-01

    Longer and heavier trains mean larger in-train forces and more complicated force patterns. Practical experience indicates that the development of fatigue failure of coupling systems in long heavy trains may differ from conventional understanding. The friction-type draft gears are the most widely used draft gears. The ever developing heavy haul transport environment requires further or new understanding of friction draft gear behaviour and its implications for train dynamics as well as fatigue damage of rolling stock. However, modelling of friction draft gears is a highly nonlinear question. Especially the poor predictability, repeatability and the discontinuity of friction make this task more challenging. This article reviews current techniques in dynamics modelling of friction draft gears to provide a starting point that can be used to improve existing or develop new models to achieve more accurate force amplitude and pattern predictions.

  14. 75 FR 69078 - Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA)

    Science.gov (United States)

    2010-11-10

    ... AGENCY Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA) AGENCY... a workshop to evaluate initial draft materials for the Pb Integrated Science Assessment (ISA) is... the scientific content of initial draft materials or sections for the draft ISA. Workshop...

  15. An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios (External Review Draft)

    Science.gov (United States)

    EPA has released an external review draft entitled, An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios(External Review Draft). The public comment period and the external peer-review workshop are separate processes that provide opportunities ...

  16. 76 FR 67439 - External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic...

    Science.gov (United States)

    2011-11-01

    ... AGENCY External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic... attend this peer review meeting as observers. Time will be set aside at the meeting for observers to give... the draft document, EPA intends to consider the comments from the external peer review meeting,...

  17. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) (Interagency Science Consultation Draft)

    Science.gov (United States)

    In September 2016, EPA released the draft IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) for public comment and discussion. The draft assessment was reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent ...

  18. 77 FR 5247 - Draft Integrated Science Assessment for Lead

    Science.gov (United States)

    2012-02-02

    ... AGENCY Draft Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency (EPA). ACTION..., ``Second External Review Draft Integrated Science Assessment for Lead'' (EPA/600/R-10/075B). The document... lead (Pb). EPA is releasing this draft document to seek review by the Clean Air Scientific...

  19. 77 FR 70776 - Draft Integrated Science Assessment for Lead

    Science.gov (United States)

    2012-11-27

    ... AGENCY Draft Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency (EPA). ACTION..., ``Third External Review Draft Integrated Science Assessment for Lead'' (EPA/600/R-10/075C). The document... lead (Pb). EPA is releasing this draft document to seek review by the Clean Air Scientific...

  20. [Draft] Biological review : Ouray National Wildlife refuge : 10-11 October 2001

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Draft biological review report for Ouray National Wildlife Refuge, located along the Green River near Vernal, Utah. The review focuses on historical and present...

  1. 78 FR 12764 - Draft Office of Health Assessment and Translation Approach for Systematic Review and Evidence...

    Science.gov (United States)

    2013-02-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Draft Office of Health Assessment and Translation Approach... comments on the Draft Office of Health Assessment and Translation (OHAT) Approach for Systematic Review...

  2. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) (Public Comment Draft)

    Science.gov (United States)

    In September 2016, the U.S. Environmental Protection Agency's (USEPA) released the draft Integrated Risk Information System (IRIS) Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE). Consistent with the 2013 IRIS Enhancements, draft IRIS assessments are released prior to e...

  3. 75 FR 69065 - Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk...

    Science.gov (United States)

    2010-11-10

    ... AGENCY Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk... the draft human health assessment titled, ``Toxicological Review of Urea: In Support of Summary... workshop on the draft assessment for Urea will be held via teleconference on December 13, 2010,...

  4. IRIS Toxicological Review of Acrylamide (External Review Draft)

    Science.gov (United States)

    EPA has conducted a peer review by EPA’s Science Advisory Board (SAB) of the scientific basis supporting the human health hazard and dose-response assessment of acrylamide that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is m...

  5. IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Review Draft)

    Science.gov (United States)

    EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of tetrachloroethylene that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and ...

  6. IRIS Toxicological Review of Acrylamide (External Review Draft)

    Science.gov (United States)

    EPA has conducted a peer review by EPA’s Science Advisory Board (SAB) of the scientific basis supporting the human health hazard and dose-response assessment of acrylamide that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is m...

  7. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    Science.gov (United States)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  8. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    Science.gov (United States)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  9. IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA is releasing the draft report, Toxicological Review of Hydrogen Cyanide (HCN) and Cyanide Salts, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS As...

  10. IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of hydrogen cyanide and cyanide salts that will appear on the Integrated Risk Information System (IRIS) database.

  11. IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of hydrogen cyanide and cyanide salts that will appear on the Integrated Risk Information System (IRIS) database.

  12. IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)

    Science.gov (United States)

    EPA is seeking additional public comment and external peer review of the scientific basis supporting the human health hazard and dose-response assessment of methanol (noncancer). Teleconference Details: The public may participate in th...

  13. IRIS Toxicological Review of Trichloroethylene (TCE) (External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroethylene (TCE) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  14. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Interagency Science Consultation Draft)

    Science.gov (United States)

    On March 10, 2016, the public comment draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by othe...

  15. IRIS Toxicological Review of Methanol (External Review Draft, 2013)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  16. 78 FR 54469 - Solicitation of Written Comments on Draft National Action Plan for Adverse Drug Event Prevention

    Science.gov (United States)

    2013-09-04

    ..., Rockville MD 20852, Attention: Draft National ADE Action Plan. FOR FURTHER INFORMATION CONTACT: Yael Harris... only the beginning of a coordinated process that will result in stakeholders who are more engaged... representing medical, nursing, pharmacy, and other allied health professionals, academia, patient and...

  17. 76 FR 55384 - External Peer Review Meeting for the Draft Guidance of Applying Quantitative Data To Develop Data...

    Science.gov (United States)

    2011-09-07

    ... AGENCY External Peer Review Meeting for the Draft Guidance of Applying Quantitative Data To Develop Data... register to attend this peer review meeting as observers. Time will be set aside for observers to give... finalizing the draft document, EPA intends to consider the comments from the external peer review...

  18. Review of the Draft K-12 Common Core Standards

    Science.gov (United States)

    Carmichael, Sheila Byrd; Wilson, W. Stephen; Martino, Gabrielle; Finn, Chester E., Jr.; Porter-Magee, Kathleen; Winkler, Amber M.

    2010-01-01

    American education approached a possible turning point when the National Governors Association (NGA) and Council of Chief State School Officers (CCSSO) released drafts of proposed new academic standards in English language arts and math for kindergarten through high school. Already the object of much interest--and some controversy--these are…

  19. Review and Update Contents of Drafting Curriculum Guides. Final Report.

    Science.gov (United States)

    Sherrell, Eugene G.

    A study was undertaken to determine whether the curriculum guides presently being used in drafting courses have changed due to the technological developments that have occurred in industry. In addition, the survey was concerned with the extent that knowledge of geometric dimensioning and tolerancing are needed by drafters, the extent that the…

  20. 76 FR 20347 - Release of Draft Integrated Review Plan for the National Ambient Air Quality Standards for Lead

    Science.gov (United States)

    2011-04-12

    ... AGENCY Release of Draft Integrated Review Plan for the National Ambient Air Quality Standards for Lead... National Ambient Air Quality Standards for Lead (draft IRP). This document contains the plans for the review of the air quality criteria and national ambient air quality standards (NAAQS) for lead (Pb)....

  1. 77 FR 51798 - First Draft Documents Related to the Review of the National Ambient Air Quality Standards for Ozone

    Science.gov (United States)

    2012-08-27

    ... AGENCY First Draft Documents Related to the Review of the National Ambient Air Quality Standards for... of the Ozone National Ambient Air Quality Standards: First External Review Draft. The Agency is...-001; July 2012), please contact Ms. Karen Wesson, Office of Air Quality Planning and Standards...

  2. Draft effect on wave action with a semi-infinite elastic plate

    Institute of Scientific and Technical Information of China (English)

    TENG Bin; GOU Ying; CHENG Liang; LIU Shuxue

    2006-01-01

    A method for analyzing reflection and transmission of ocean waves from a semi-infinite elastic plate with a draft is developed. The relation of energy conservation for plates with three different edge conditions (free, simply supported and built-in) is also derived. It is found that the present method satisfies the energy relation very well. The effects of draft on wave reflection and transmission coefficients as well as on the vertical vibration of the plates are examined through numerical tests. It is demonstrated that the zero draft assumption works well for low wave frequencies, but the effect of plate draft becomes significant for high wave frequencies.

  3. 76 FR 80948 - Draft Guidance for Industry, Clinical Investigators, Institutional Review Boards, and Food and...

    Science.gov (United States)

    2011-12-27

    ... developed to promote the initiation of clinical investigations to evaluate the medical devices under FDA's... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry, Clinical Investigators, Institutional Review Boards, and Food and Drug Administration Staff; Food and Drug Administration Decisions...

  4. 78 FR 17201 - Pesticide Chemicals; Registration Review; Draft Human Health and Ecological Risk Assessments...

    Science.gov (United States)

    2013-03-20

    ... AGENCY Pesticide Chemicals; Registration Review; Draft Human Health and Ecological Risk Assessments... environment, or a human dietary risk from residues that result from the use of a pesticide in or on food. III... these pesticides can still be used without unreasonable adverse effects on human health or the...

  5. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (Interagency Science Discussion Draft)

    Science.gov (United States)

    EPA released the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from ot...

  6. Basins 4.0 Climate Assessment Tool (Cat): Supporting Documentation and User Manual (External Review Draft)

    Science.gov (United States)

    EPA has released of the draft document solely for the purpose of pre-dissemination peer review under applicable Information Quality Guidelines (IQGs). This document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agenc...

  7. 75 FR 50761 - Draft Toxicological Review of Dichloromethane: In Support of Summary Information on the...

    Science.gov (United States)

    2010-08-17

    ... risks of chemical substances in a site-specific situation and thereby support risk management decisions... support the first two steps (hazard identification and dose-response evaluation) of the risk assessment... AGENCY Draft Toxicological Review of Dichloromethane: In Support of Summary Information on the...

  8. Less Than Proficient A Review of the Draft Science Framework for the 2009 National Assessment of Educational Progress

    Science.gov (United States)

    Gross, Paul R.

    2005-01-01

    The mission of this review is to appraise the new draft NAEP science framework and to determine whether it is up to snuff. This is an evaluation of the September 30, 2005, draft document, Science Framework for the 2009 National Assessment of Educational Progress (Framework), developed for the National Assessment Governing Board. The criteria is…

  9. 78 FR 70047 - Request for the Technical Review of 25 Draft Skin Notation Assignments and Skin Notation Profiles

    Science.gov (United States)

    2013-11-22

    ... draft Skin Notation Profiles were developed to provide the scientific rationale behind the hazard... Skin Notation Assignments and Skin Notation Profiles AGENCY: National Institute for Occupational Safety... review of the draft skin notations and supporting technical documents entitled, Skin Notations Profiles...

  10. Draft safety review plan for accelerator production of tritium (APT) project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The purpose of this ``living`` Safety Review Plan (SRP) is to describe the products and processes that will be followed to conduct a systematic review of the Accelerator Production of Tritium (APT) Facility Preliminary Safety Analysis Report (PSAR), and subsequently to prepare a draft Safety Evaluation Report (SER) on the PSAR. This plan is prepared for and will be implemented by the APT Independent Safety Review Committee (ISRC) over the period July 1, 1997 through September 30, 1998, in accordance with provisions established in DOE-STD-1104-96. A core team of DOE, INEEL, and AMPARO Corporation engineers and scientists will prepare the initial draft SER with assistance from other ISRC team members on an as needed basis. Guidelines for preparing the draft SER are presented in Section 7 of this SRP. The PSAR reviews will focus exclusively on safety. The ever-present two-part question will be: Does the subject matter have safety significance? If so, does the APT structural, system, component, and/or process engineering design ensure an acceptable margin of safety? The APT mission, efficiency, and cost are not considerations of this plan. A more detailed discussion of the review philosophy is presented in Section 5 of this SRP.

  11. 76 FR 38650 - Draft Integrated Science Assessment for Lead

    Science.gov (United States)

    2011-07-01

    ... AGENCY Draft Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency. ACTION... Draft Integrated Science Assessment for Lead'' (EPA/600/R-10/075A). The original Federal Register notice... Development as part of the review of the National Ambient Air Quality Standards (NAAQS) for Lead. DATES:...

  12. 76 FR 61704 - Availability of Draft NTP Monograph on the Health Effects of Low-Level Lead; Request for Comments...

    Science.gov (United States)

    2011-10-05

    ... HUMAN SERVICES Availability of Draft NTP Monograph on the Health Effects of Low- Level Lead; Request for Comments; Announcement of a Panel Meeting to Peer Review Draft Monograph AGENCY: Division of the National... of Health. ACTION: Availability of Draft NTP Monograph; Request for Comments; Announcement of a Peer...

  13. 76 FR 55391 - Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of...

    Science.gov (United States)

    2011-09-07

    ... HUMAN SERVICES Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy During Pregnancy and Panel Meeting To Peer Review Draft Monograph AGENCY... (NIEHS), National Institutes of Health. ACTION: Notice of postponement of draft NTP monograph and peer...

  14. 77 FR 76474 - Extension of Public Review and Comment Period for the Draft Programmatic Environmental Assessment...

    Science.gov (United States)

    2012-12-28

    ... Draft Programmatic Environmental Assessment for the Recycling of Scrap Metals Originating From... of availability for the Draft Programmatic Environmental Assessment (PEA) for the Recycling of Scrap... address printed in the Draft PEA was correct and now both that email address (...

  15. After Action Reviews: Current Observations and Recommendations

    Science.gov (United States)

    2007-01-01

    without a verbatim quotation from the first paragraph of the 1993 Training Circular (TC 25-20), A Leader’s Guide to After-Action Reviews. It states...Viet Nam Wars. Marshall spoke with Soldiers in theatre , immediately after combat actions, and although sometimes disparaged because of limited numbers...1). The current EXROE has expanded from 15 to 22 chapters to reflect changes in training offered, but the AAR bottom line is repeated 8 verbatim in

  16. Development of a draft of human factors safety review procedures for the Korean next generation reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Woon; Moon, B. S.; Park, J. C.; Lee, Y. H.; Oh, I. S.; Lee, H. C. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-02-01

    In this study, a draft of human factors engineering (HFE) safety review procedures (SRP) was developed for the safety review of KNGR based on HFE Safety and Regulatory Requirements and Guidelines (SRRG). This draft includes acceptance criteria, review procedure, and evaluation findings for the areas of review including HFE Program Management, Human Factors Analyses, Human Factors Design, and HFE Verification and Validation, based on Section 15.1 'Human Factors Engineering Design Process' and 15.2 'Control Room Human Factors Engineering' of KNGR Specific Safety Requirements and Chapter 15 'Human Factors Engineering' of KNGR Safety Regulatory Guides. For the effective review, human factors concerns or issues related to advanced HSI design that have been reported so far should be extensively examined. In this study, a total of 384 human factors issues related to the advanced HSI design were collected through our review of a total of 145 documents. A summary of each issue was described and the issues were identified by specific features of HSI design. These results were implemented into a database system. 8 refs., 2 figs. (Author)

  17. 75 FR 39253 - Release of Second Draft Document Related to the Review of the National Ambient Air Quality...

    Science.gov (United States)

    2010-07-08

    ... AGENCY Release of Second Draft Document Related to the Review of the National Ambient Air Quality... Assessment for the Review of the Particulate Matter National Ambient Air Quality Standards--Second External... revise the standards as part of the review of the national ambient air quality standards (NAAQS)...

  18. 75 FR 29588 - Office of New Reactors: Proposed NUREG-0800; Standard Review Plan Section 13.6.6, Draft Revision...

    Science.gov (United States)

    2010-05-26

    ... NUREG-0800; Standard Review Plan Section 13.6.6, Draft Revision 0 on Cyber Security Plan AGENCY: Nuclear... public comment on NUREG-0800, ``Standard Review Plan for the Review of Safety Analysis Reports for... revision of NUREG-0800, SRP Section 13.6.6 and Regulatory Guide 1.206, ``Combined License Applications...

  19. 77 FR 56202 - Notification of an External Peer Review Meeting for the Draft Framework for Human Health Risk...

    Science.gov (United States)

    2012-09-12

    ... AGENCY Notification of an External Peer Review Meeting for the Draft Framework for Human Health Risk... external peer review meeting. SUMMARY: The EPA Office of the Science Advisor announces that Versar, Inc., a... attend this peer review meeting as an observer. Time will be set aside for observers to give brief...

  20. Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised August 2014 External Review Draft) (SAB Review Draft)

    Science.gov (United States)

    EPA is seeking peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene oxide (cancer) that will appear in the Integrated Risk Information System (IRIS) database.

  1. Evaluation of Regional Sediment Management Actions Using Government Shallow Draft Dredges

    Science.gov (United States)

    2013-03-01

    USACE clamshell bucket dredge SNELL. ERDC/CHL CHETN-XIV-26 March 2013 4 DISCUSSION. The shallow draft dredge fleet efficiently and cost...The SNELL, a utility vessel equipped with a clamshell bucket for mechanical dredging. This vessel also has a submersible pump that can be used for...such as the SNELL’s, taking suction from their hoppers and pumping ashore; or  Dedicated pump-out equipment, mounted/installed on each vessel, to

  2. 77 FR 45357 - Draft Guidance for Industry and Food and Drug Administration Staff; Acceptance and Filing Review...

    Science.gov (United States)

    2012-07-31

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Drug Administration, HHS. ACTION: Notice. ] SUMMARY: The Food and Drug Administration (FDA) is... Consumer Assistance, Center for Devices and Radiological Health, Food and Drug Administration, 10903...

  3. The process of consensus on EMF: SAB review of the EPA draft document on EMF and cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, B.W.

    1992-06-01

    The EPA Draft Document on EMF and Cancers grew out of an earlier effort by EPA to track biological effects literature relative to radio-frequency (RF) exposure. Scope of the document was broadened to include extremely low frequency electric and magnetic fields prior to an announcement in 1986 that EPA would formally review the whole area of non-ionizing radiation. An extensive survey of the relevant bioeffects and epidemiologic literature was carried out, and writing on the document began in earnest on the document sometime in 1989. In its draft form, the document reviewed the literature on mechanisms of Interaction between electromagnetic fields and biological tissue, EMF epidemiologic studies, supporting evidence for carcinogenicity and research needs. In the early summer of 1990, a draft of the document was reviewed by some 22 individuals within the EPA and other government agencies. It was also sent out for external review to an additional 9 qualified scientists who had worked in the area and were familiar with EMF-related literature in epidemiology, biology, and physics. Many of the comments sent to EPA from this first review, prior to release of the draft for public comment, were strikingly similar to those resulting from the second (public) review process. Thus, it appears that much of the controversy that was later associated with the document could have been avoided had the authors been diligent in following the recommendations of the initial set of reviewers.

  4. 77 FR 66626 - Deepwater Horizon Oil Spill; Draft Early Restoration Plan and Environmental Review

    Science.gov (United States)

    2012-11-06

    ... Assessment (Phase I ERP/EA) in April 2012. The Phase I ERP is currently being implemented. In a continuation... to satisfy claims against BP. Overview of the Draft ERP/ER Draft Early Restoration Plan Alternatives, Including Our Proposed Alternative The Draft ERP/ER is being released in accordance with the Oil...

  5. 75 FR 81643 - Hydropower Resource Assessment at Existing Reclamation Facilities-Draft Report

    Science.gov (United States)

    2010-12-28

    ... Bureau of Reclamation Hydropower Resource Assessment at Existing Reclamation Facilities--Draft Report AGENCIES: Bureau of Reclamation, Interior. ACTION: Reopening of comment period for review of the Hydropower... committed to increasing the generation of environmentally sustainable, affordable hydropower for our...

  6. 77 FR 36001 - Draft Report Assessing Rural Water Activities and Related Programs

    Science.gov (United States)

    2012-06-15

    ... Bureau of Reclamation Draft Report Assessing Rural Water Activities and Related Programs AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of availability. SUMMARY: The draft Rural Water Assessment Report reviews the status of the Bureau of Reclamation's rural potable water projects and its plan for...

  7. 78 FR 9387 - Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation Plan

    Science.gov (United States)

    2013-02-08

    ... AGENCY Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation Plan... Agency Climate Change Adaptation Plans in response to the President's October 2009 Executive Order (E.O... of EPA's Climate Change Adaptation Plan has been posted to a public docket and is available on...

  8. 77 FR 44613 - Notice of Availability of the External Review Draft of Framework for Human Health Risk Assessment...

    Science.gov (United States)

    2012-07-30

    ... AGENCY Notice of Availability of the External Review Draft of Framework for Human Health Risk Assessment... health risk assessments that are responsive to the needs of decision making processes at the EPA. The... established history of conducting human health risk assessments. The Framework is intended to foster increased...

  9. 77 FR 12836 - Draft Toxicological Review of Biphenyl: In Support of Summary Information on the Integrated Risk...

    Science.gov (United States)

    2012-03-02

    ... be used to support the first two steps (hazard identification and dose-response evaluation) of the... management decisions designed to protect public health. Dated: February 23, 2012. Darrell A. Winner, Acting... AGENCY Draft Toxicological Review of Biphenyl: In Support of Summary Information on the Integrated...

  10. An Assessment of Potential Mining Impacts on Salmon Ecosystems of Bristol Bay, Alaska (Second External Review Draft)

    Science.gov (United States)

    [UPDATE] In March 2014, EPA released a response to public comments on the second draft document, "An Assessment of the Potential Mining Impacts on Salmon Ecosystems of Bristol Bay, Alaska" (see downloads). In Jan 2014, EPA released a response to peer review comme...

  11. An Assessment of Potential Mining Impacts on Salmon Ecosystems of Bristol Bay, Alaska (First External Review Draft)

    Science.gov (United States)

    [UPDATE] In March 2014, EPA released a response to public comments on the draft document, "An Assessment of the Potential Mining Impacts on Salmon Ecosystems of Bristol Bay, Alaska" (see downloads). In Jan 2014, EPA released a response to peer review comments on ...

  12. 75 FR 22148 - Request for the Technical Review of 22 Draft Skin Notation Assignments and Skin Notation Profiles

    Science.gov (United States)

    2010-04-27

    ... Profiles were developed to provide the scientific rationale behind the hazard-specific skin notation (SK... Skin Notation Assignments and Skin Notation Profiles AGENCY: National Institute for Occupational Safety... public review of the draft skin notations and support technical documents entitled ``Skin Notations...

  13. HERBAL REMEDIES FOR GASTROPROTECTIVE ACTION: A REVIEW

    Directory of Open Access Journals (Sweden)

    Ramesh Patel

    2012-05-01

    Full Text Available Herbal medicines have great importance in maintaining the health of every person. Demands of Herbal medicines are increasing in both developed and developing countries due to growing recognition of natural plants being lesser no. of side effect, easily available in surrounding place with low coast. Different parts of the plant have different active substances and these active substances may vary in their extent of activity and concentration. Most of active principles are present in leaves, flower, fruit, bark, root & seeds of the plant. Gastric diseases are a major and worldwide very common problem in every age of person. Its 90% arises commonly due to mostly used of non-steroidal anti-inflammatory category of drug and about 8 to 10% by used of most spicy and fast food(Junk Food. In this review we have described some medicinal plants with respect to their Gastroprotective action.

  14. Canadian support for population stabilization. The Rome draft Plan of Action. Dr. Jean Augustine, MP (Canada).

    Science.gov (United States)

    1996-01-01

    Canada strongly believes in the central role to be played by the civil sector in the process leading to the World Food Summit. Dr. Augustine, Member of Parliament of Canada, described how the Canadian Government involved 350 national organizations over an eight-month period in the creation of the country's official position on food security. Canada has also negotiated with several other countries and international organizations on issues such as trade, human rights, the right to food, and follow-up to the Plan of Action. Dr. Augustine summarized Canada's 18 priorities for the World Food Summit. The priorities include human rights and good governance; poverty reduction; peace, security and conflict resolution; national responsibility for food security; national and global partnerships; nutrition and health; human resource development; gender equity; population stabilization; trade liberalization; agricultural adjustment to international markets; post-harvest marketing and food marketing; the role of the private sector; capacity building; environment and sustainable production; and research and technology transfer.

  15. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (Tcdd) and Related Compounds: Science Advisory Board (External Review Draft) (2000)

    Science.gov (United States)

    Dioxin Reassessment, SAB Review Draft The U.S. Environmental Protection Agency's (EPA) is progressing toward completion of its comprehensive reassessment of dioxin science entitled, "Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibe...

  16. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (Tcdd) and Related Compounds: Science Advisory Board (External Review Draft) (2000)

    Science.gov (United States)

    Dioxin Reassessment, SAB Review Draft The U.S. Environmental Protection Agency's (EPA) is progressing toward completion of its comprehensive reassessment of dioxin science entitled, "Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibe...

  17. 76 FR 15968 - Notice of Availability of the Draft Environmental Impact Statement and Public Hearing Notice for...

    Science.gov (United States)

    2011-03-22

    ... under the Clean Coal Power Initiative (CCPI) program. DOE prepared this draft EIS in accordance with the... Clean Energy Project, near Odessa, Ector County, TX AGENCY: Department of Energy. ACTION: Notice of... Texas Clean Energy Project Draft Environmental Impact Statement (DOE/EIS-0444D) for public review...

  18. 78 FR 14305 - Draft Guidance for Industry and Food and Drug Administration Staff; Types of Communication During...

    Science.gov (United States)

    2013-03-05

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is... efficiency of the review process. This draft guidance is not final nor is it in effect at this time....

  19. From Systematic Review to Call for Action.

    Science.gov (United States)

    Sawin, Erika Metzler; Sobel, Linda L; Annan, Sandra L; Schminkey, Donna L

    2017-06-01

    Intimate partner violence (IPV) is a global public health and criminal justice concern with significant impacts; especially high rates are seen among rural Hispanic American (HA) communities, the fastest growing population in the United States. They experience additional barriers to care including extreme poverty, lesser education, gender norms, and language and immigration issues. A systematic literature review was conducted using Cooper's framework to identify evidence supporting associations between interventions and prevention, reduction, and elimination of IPV among rural HA women. Searches conducted on databases including CINAHL, PubMed, Medline, Women's Studies International, MedicLatina, and JSTOR used the MeSH terms Hispanic Americans (Latino/a and Hispanic), domestic violence, and intimate partner violence. Selected studies were published between January 1, 2000, and January 1, 2014. Of the 617 yielded articles, only 6 met the inclusion criteria. Of these, none closely examined rurality or provided valid and reliable measures of outcomes, instead reporting program descriptions and suggested interventions. We identify key findings to guide program, screening, and tool development. Our study identifies a gap in knowledge, research, and effective practices and issues a call for action to create evidence-based tools to prevent, reduce, and eliminate IPV in these underserved populations.

  20. Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised July 2013 External Review Draft) (Public Comment Draft)

    Science.gov (United States)

    EPA is initiating a public comment period prior to peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene oxide (cancer) that will appear in the Integrated Risk Information System (IRIS) database.

  1. 75 FR 51838 - Public Review of Draft Coastal and Marine Ecological Classification Standard

    Science.gov (United States)

    2010-08-23

    ... public on the FGDC Web site. DATES: Comments on the draft Coastal and Marine Ecological Classification... technology and information. Dated: August 13, 2010. Ivan DeLoatch, FGDC Executive Director. [FR Doc....

  2. 75 FR 16837 - Public Review of Draft United States Thoroughfare, Landmark, and Postal Address Data Standard

    Science.gov (United States)

    2010-04-02

    ... public on the FGDC Web site. DATES: Comments on the draft United States Thoroughfare, Landmark, and... principles can be extended to all addresses. Dated: March 18, 2010. Ivan DeLoatch, FGDC Executive...

  3. IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR BORON AND COMPOUNDS (THIRD EXTERNAL REVIEW DRAFT 2002)

    Science.gov (United States)

    The U. S. EPA has conducted a peer review of the scientific basis supporting the health hazard and dose response assessment for Boron that will appear on the Agency's online data base, the Integrated Risk Information System (IRIS). Peer Review is meant to ensure that science is u...

  4. A REVIEW ON SALE REVENUE AND TRADE RECEIVABLE ACCOUNTING PROPOSED IN THE DRAFT OF LOCAL FINANCIAL REPORTING FRAMEWORK

    Directory of Open Access Journals (Sweden)

    Gülümser ÜNKAYA

    2016-08-01

    Full Text Available The Draft of Local Financial Reporting Framework issued by Public Oversight Accounting and Auditing Standards Authority for companies which are subject to audit but do not use Turkish Financial Reporting Standards/Turkish Accounting Standards proposes that sale revenue is reported with value of sale for the account and the receivable should be reported with present value calculated with rediscount transaction made by using nominal interest method. Within the scope of sale revenue, trade receivable and qualified financial information concepts, the article reviews the proposal of the draft and puts forward that sale revenue should be reported with value of spot sale and the difference should be considered interest income to be amortized with the rate applied in the transaction, using effective interest method.

  5. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (External Review Draft)

    Science.gov (United States)

    EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene glycol monobutyl ether that will appear on the Integrated Risk Information System (IRIS) database.

  6. IRIS Toxicological Review of Beryllium and Compounds (2008 External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Beryllium that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  7. 78 FR 45983 - Acceptability of Corrective Action Programs for Fuel Cycle Facilities

    Science.gov (United States)

    2013-07-30

    ...The U.S. Nuclear Regulatory Commission (NRC) is withdrawing draft NUREG-2154, ``Acceptability of Corrective Action Programs for Fuel Cycle Facilities,'' based on receipt and review of public comments. The draft NUREG provided guidance to NRC staff on how to determine whether a submittal for a Corrective Action Program (CAP), voluntarily submitted by fuel cycle facility licensees, was......

  8. Final Independent External Peer Review Report for the Intake Diversion Dam Modification Lower Yellowstone Project, Montana Draft Supplement to the 26 April 2010 Environmental Assessment and Appendices

    Science.gov (United States)

    2013-02-08

    February 8, 2013 Final Independent External Peer Review Report for the Intake Diversion Dam Modification Lower Yellowstone Project, Montana...Final Independent External Peer Review Report for the Intake Diversion Dam Modification Lower Yellowstone Project, Montana Draft Supplement to the...Intake Project IEPR Final IEPR Report Intake Project IEPR Final IEPR Report Final Independent External Peer Review Report for the

  9. IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  10. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) (External Review Draft, 2009)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of ethyl tertiary butyl ether (ETBE) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  11. Review: Ernest T. Stringer (2007. Action Research

    Directory of Open Access Journals (Sweden)

    Tobias Denskus

    2008-10-01

    Full Text Available STRINGER's book on action research provides an accessible introduction to conducting participatory inquiries for social change. This general overview of the theoretical foundations of action research and methodological challenges is enriched by practical examples, insights, and exercises that are based on the author's substantial experience as a researcher and practitioner. Students and teachers will find this a valuable resource for teaching and training. However, STRINGER's positive outlook on humanity and communities and his non-confrontational style of action research ignores some of the "darker" sides of power, knowledge, and the difficulties of achieving sustainable social change. The final chapter and substantial appendices have a strong focus on traditional report writing; more alternative case studies on how to communicate action research may have been useful to balance his more conventional project-management approach. Overall, this is a very good introductory volume that can spark ideas, discussions, and (self- reflection on how to better link theory and practice. URN: urn:nbn:de:0114-fqs0901108

  12. Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray (External Review Draft)

    Science.gov (United States)

    This draft document presents a case study of engineered nanoscale silver (nano-Ag), focusing on the specific example of nano-Ag as possibly used in disinfectant sprays. This case study is organized around a comprehensive environmental assessment (CEA) framework, which combines a ...

  13. Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray (External Review Draft)

    Science.gov (United States)

    This draft document presents a case study of engineered nanoscale silver (nano-Ag), focusing on the specific example of nano-Ag as possibly used in disinfectant sprays. This case study is organized around a comprehensive environmental assessment (CEA) framework, which combines a ...

  14. 76 FR 70151 - Draft Guidance for Industry, Clinical Investigators, Institutional Review Boards, and Food and...

    Science.gov (United States)

    2011-11-10

    ... to evaluate medical devices under FDA's IDE regulations. In an effort to promote timely clinical... available at http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/default.htm... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry, Clinical...

  15. 75 FR 73085 - National Toxicology Program (NTP): Office of Liaison, Policy, and Review; Availability of Draft...

    Science.gov (United States)

    2010-11-29

    ... any other correspondence on the draft TRs should be sent to Dr. Lori White, NIEHS, P.O. Box 12233, MD... minutes will be allotted to each speaker, and if time permits, may be extended to 10 minutes at the... that for pre-registered speakers and will be determined by the number of persons who register...

  16. 76 FR 8741 - National Toxicology Program (NTP): Office of Liaison, Policy, and Review; Availability of Draft...

    Science.gov (United States)

    2011-02-15

    ... any other correspondence on the draft TRs should be sent to Danica Andrews, NIEHS, P.O. Box 12233, MD... report. At least 7 minutes will be allotted to each speaker, and if time permits, may be extended to 10... registrants may be less than that for pre- registered speakers and will be determined by the number of...

  17. Towards new educational potentialities: Review and commentary of the Preliminary draft Act on higher education

    Directory of Open Access Journals (Sweden)

    Madžar Ljubomir

    2005-01-01

    Full Text Available The Higher Education Act is a long-awaited legal act. A number of uncompleted attempts to prepare it have been undertaken in the course of the last three years. So far without success. Having been and still being a matter of highest social priority, the renewed effort to create and subsequently to enact this act is welcome as a worthwhile and a highly productive endeavor. Welcome also are the main innovations offered by this act, particularly its conspicuous consistency with the Bologna Declaration and other internationally launched and accepted documents. The draft act follows the international documents tracing down the paths of the future development of the educational systems of the European countries and providing for their mutual compatibility. A number of other positive contributions of the draft act are singled out, such as introducing clear and rigorous criteria and procedures for accreditation and quality control, introducing a wide coverage of arts and sciences as a precondition for an institution of higher education to qualify as a university, flexibility in the regime of studying including the domestic and international mobility of the students and requirement for the schools of higher education to have large cores of permanently employed teaching staff. A much larger part of the paper is, however, devoted to critical commentaries. To begin with, the draft is produced without any participation of the private universities, which is seen as a form of discrimination. The organizational pattern of a university is laid out with insufficient clarity and the status of departments (faculties is particularly short of precision and even contradictory. The draft seems to be laden with the old bias towards excessive and potentially disastrous centralization, drastically reducing the decision making capacity of the system. The treatment of the property of the departments (faculties is found inconsistent and legally unfounded. Inconsistency is

  18. 75 FR 73078 - Human Studies Review Board (HSRB); Notification of a Public Teleconference To Review Draft Report...

    Science.gov (United States)

    2010-11-29

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION... EPA HSRB can be found on the EPA Web site at http://www.epa.gov/osa/hsrb/ . ADDRESSES: Submit your...://www.epa.gov/osa/hsrb/ . The October 27-28, 2010 meeting draft report is now available. You may...

  19. Mini Review: Mode of Action of Mosquito Repellents

    Science.gov (United States)

    2013-01-01

    Mini review: Mode of action of mosquito repellents Joseph C. Dickens ⇑, Jonathan D. Bohbot United States Department of Agriculture, Agricultural...Modulation a b s t r a c t The mode of action of mosquito repellents remains a controversial topic. However, electrophysiological studies and molecular...annoyance that can disrupt outdoor activities. The use of repellents decreases contacts between mosquitoes and their hosts, and may even lower the rate of

  20. Corrective Action Investigation Plan for Corrective Action Unit 556: Dry Wells and Surface Release Points Nevada Test Site, Nevada (Draft), Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Grant Evenson

    2007-02-01

    Corrective Action Unit  (CAU) 556, Dry Wells and Surface Release Points, is located in Areas 6 and 25 of the Nevada Test Site, 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 556 is comprised of four corrective action sites (CASs) listed below: •06-20-04, National Cementers Dry Well •06-99-09, Birdwell Test Hole •25-60-03, E-MAD Stormwater Discharge and Piping •25-64-01, Vehicle Washdown and Drainage Pit These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  1. Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines

    Institute of Scientific and Technical Information of China (English)

    Barry M Berger; Bernard Levin; Robert J Hilsden

    2016-01-01

    Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an "alternative" screening test that "may be useful in select clinical circumstances",despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF’s modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening.

  2. Nanomaterial Case Study: A Comparison of Multiwalled Carbon Nanotube and Decabromodiphenyl Ether Flame-Retardant Coatings Applied to Upholstery Textiles (Independent Peer Review Draft)

    Science.gov (United States)

    This Independent Peer Review Draft document presents a case study of multiwalled carbon nanotubes (MWCNTs); it focuses on the specific example of MWCNTs as used in flame-retardant coatings applied to upholstery textiles. This case study is organized around the comprehensive envir...

  3. An Assessment of Decision-Making Processes: The Feasibility of Incorporating Climate Change Information into Land Protection Planning (External Review Draft)

    Science.gov (United States)

    This report was prepared by the Global Change Research Program (GCRP) in the National Center for Environmental Assessment (NCEA) of the Office of Research and Development (ORD) at the U.S. Environmental Protection Agency (EPA). This draft report is a review of decision-making pro...

  4. Nanomaterial Case Study: A Comparison of Multiwalled Carbon Nanotube and Decabromodiphenyl Ether Flame-Retardant Coatings Applied to Upholstery Textiles (Independent Peer Review Draft)

    Science.gov (United States)

    This Independent Peer Review Draft document presents a case study of multiwalled carbon nanotubes (MWCNTs); it focuses on the specific example of MWCNTs as used in flame-retardant coatings applied to upholstery textiles. This case study is organized around the comprehensive envir...

  5. A review of action estimation methods for galactic dynamics

    Science.gov (United States)

    Sanders, Jason L.; Binney, James

    2016-04-01

    We review the available methods for estimating actions, angles and frequencies of orbits in both axisymmetric and triaxial potentials. The methods are separated into two classes. Unless an orbit has been trapped by a resonance, convergent, or iterative, methods are able to recover the actions to arbitrarily high accuracy given sufficient computing time. Faster non-convergent methods rely on the potential being sufficiently close to a separable potential, and the accuracy of the action estimate cannot be improved through further computation. We critically compare the accuracy of the methods and the required computation time for a range of orbits in an axisymmetric multicomponent Galactic potential. We introduce a new method for estimating actions that builds on the adiabatic approximation of Schönrich & Binney and discuss the accuracy required for the actions, angles and frequencies using suitable distribution functions for the thin and thick discs, the stellar halo and a star stream. We conclude that for studies of the disc and smooth halo component of the Milky Way, the most suitable compromise between speed and accuracy is the Stäckel Fudge, whilst when studying streams the non-convergent methods do not offer sufficient accuracy and the most suitable method is computing the actions from an orbit integration via a generating function. All the software used in this study can be downloaded from https://github.com/jls713/tact.

  6. 75 FR 28073 - Draft Regulatory Guide: Issuance, Availability

    Science.gov (United States)

    2010-05-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-3039, ``Standard Format and Content...

  7. 75 FR 48382 - Draft Regulatory Guide: Issuance, Availability

    Science.gov (United States)

    2010-08-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1228, ``Standard Format and Content...

  8. Guidance for the Review of Changes to Human Actions

    Science.gov (United States)

    2004-02-01

    NUREG -1764 Guidance for the Review of Changes to Human Actions AA Final Report m 20100715129 •"eaii U.S. Nuclear Regulatory Commission...Material As of November 1999, you may electronically access NUREG -series publications and other NRC records at NRC’s Public Electronic Reading Room at...http://www.nrc.gov/readinq-rm.html. Publicly released records include, to name a few, NUREG -series publications; Federal Register notices

  9. 49 CFR 520.25 - External review of draft environmental impact statements.

    Science.gov (United States)

    2010-10-01

    ... standards, noise), the DEIS shall be sent to EPA. (iii) For actions which would affect any property that is... libraries, and furnished to public and private organizations and individuals with special expertise...

  10. North Mississippi Refuges Complex Biological Program 'Pulse-Check' Review - DRAFT REPORT

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Biological review for the three refuges of the North Mississippi Refuges Complex is presented. Review is based on an assessment of addressing goals and objectives...

  11. 76 FR 20349 - Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the...

    Science.gov (United States)

    2011-04-12

    ... Peer Review Workshop. SUMMARY: EPA is announcing that Eastern Research Group, Inc., an EPA contractor for external scientific peer review, will convene an independent panel of experts and organize and... peer review workshop for comments from the public. Please inform Eastern Research Group, Inc. if...

  12. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 8: Aerothermodynamics Automation and Robotics (A/R) systems sensors, high-temperature superconductivity

    Science.gov (United States)

    1991-01-01

    Viewgraphs of briefings presented at the SSTAC/ARTS review of the draft Integrated Technology Plan (ITP) on aerothermodynamics, automation and robotics systems, sensors, and high-temperature superconductivity are included. Topics covered include: aerothermodynamics; aerobraking; aeroassist flight experiment; entry technology for probes and penetrators; automation and robotics; artificial intelligence; NASA telerobotics program; planetary rover program; science sensor technology; direct detector; submillimeter sensors; laser sensors; passive microwave sensing; active microwave sensing; sensor electronics; sensor optics; coolers and cryogenics; and high temperature superconductivity.

  13. A review on balya action mentioned in Ayurveda.

    Science.gov (United States)

    Mahesh, T S; Shreevidya, M

    2014-04-01

    Medicinal and dietary substances have been used for various purposes including nutritional from time immemorial. Various activities such as immunomodulator, bulk promoting, nutritional, etc. that enhance strength, immunity, bulk of the body resulted by the use of medicinal or dietary substances are termed in total as Balya in Ayurveda. The term Balya originally stands for all those actions that enhance the "Bala". The word "Bala" refers to the strength and ability of the body or part of the body to cope up with various physical stressors. This term "Bala" refers to various body components and functions as per the science of Ayurveda. Even in the presence of modern scientific knowledge regarding body strength, Ayurveda concepts add varied dimensions to provide detailed explanation of Balya term. The balya action is critically analyzed and discussed in this review.

  14. EEAS 2.0: draft recommendations for the 2013 EEAS Review

    NARCIS (Netherlands)

    Blockmans, Steven; Cremona, Marise; Curtin, Deirdre; Baere, de Geert; Duke, Simon; Eckes, Christina; Hillion, Christophe; Vooren, Bart; Wessel, Ramses; Wouters, Jan

    2013-01-01

    This document offers recommendations for the amendment of Council Decision 2010/427/EU establishing the organisation and functioning of the European External Action Service (hereinafter ‘EEAS Decision’). These recommendations have been distilled from discussions between academics and practitioners d

  15. Environmental assessment of remedial action at the Slick Rock uranium mill tailings sites Slick Rock, Colorado. Draft

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-06-01

    The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA) authorized the US Department of Energy (DOE) to clean up two uranium mill tailings processing sites near Slick Rock, Colorado, in San Miguel County. The purpose of the cleanup is to reduce the potential health effects associated with the radioactive materials remaining on the sites and on vicinity properties (VP) associated with the sites. The US Environmental Protection Agency (EPA) promulgated standards for the UMTRCA that contained measures to control the contaminated materials and to protect the groundwater from further degradation. Remedial actions at the Slick Rock sites must be performed in accordance with these standards and with the concurrence of the US Nuclear Regulatory Commission (NRC).

  16. Evaluation of the Carcinogenicity of Ethylene Oxide (2006 External Review Draft)

    Science.gov (United States)

    EPA conducted a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of ethylene oxide (cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  17. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (External Review Draft)

    Science.gov (United States)

    The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis suppor...

  18. 19 CFR 207.63 - Circulation of draft questionnaires.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

  19. Review and assessments of potential environmental, health and safety impacts of MHD technology. Final draft

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    The purpose of this document is to develop an environmental, health and safety (EH and S) assessment and begin a site - specific assessment of these and socio - economic impacts for the magnetohydrodynamics program of the United States Department of Energy. This assessment includes detailed scientific and technical information on the specific EH and S issues mentioned in the MHD Environmental Development Plan. A review of current literature on impact-related subjects is also included. This document addresses the coal-fired, open-cycle MHD technology and reviews and assesses potential EH and S impacts resulting from operation of commercially-installed technology.

  20. 77 FR 34958 - Draft Guidance for Institutional Review Boards, Clinical Investigators, and Sponsors...

    Science.gov (United States)

    2012-06-12

    ... 20852-1448 (1-800-835-4709 or 301-827-1800); or the Division of Small Manufacturers, International and... studies for which IRB oversight is being transferred; ensuring availability and retention of pertinent records; establishing an effective date for the transfer; conducting a review of research by the...

  1. 78 FR 59685 - Registration Review; Draft Human Health and Ecological Risk Assessment; Notice of Availability

    Science.gov (United States)

    2013-09-27

    ... Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Procedural Regulations for Registration Review at... March 27, 2013, jointly developed with the U.S. Department of Agriculture, the National Marine Fisheries... wettable powder (WP) products intended for use in agriculture to control broadleaf weeds in field corn...

  2. 75 FR 26956 - Draft Toxicological Review of Hexachloroethane: In Support of the Summary Information in the...

    Science.gov (United States)

    2010-05-13

    ... if you will need audio-visual aid (e.g., lap top computer and slide projector). In general, each... review and the public comments. All presentations submitted to EPA according to the instructions below... presentation at the listening session, you should register by June 9, 2010, indicate that you wish to make...

  3. 42 CFR 405.1108 - MAC actions when request for review or escalation is filed.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false MAC actions when request for review or escalation...) Medicare Appeals Council Review § 405.1108 MAC actions when request for review or escalation is filed. (a) Except as specified in paragraphs (c) and (d) of this section, when a party requests that the MAC review...

  4. 42 CFR 423.2108 - MAC Actions when request for review is filed.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false MAC Actions when request for review is filed. 423... Hearings, MAC review, and Judicial Review § 423.2108 MAC Actions when request for review is filed. (a) General. Except as specified in paragraph (c) of this section, when an enrollee requests that the MAC...

  5. Human-system interface design review guideline: The development of draft revision 1 to NUREG-0700

    Energy Technology Data Exchange (ETDEWEB)

    O`Hara, J.; Stubler, W.; Brown, W. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1996-03-01

    Advanced human-system interface (HSI) technologies are being developed in the commercial nuclear power industry. These HSIs may have significant implications for plant safety in that they will affect the ways in which the operator interacts with and supervises an increasingly complex system. The U.S. Nuclear Regulatory Commission (NRC) reviews the HSI aspects of nuclear plants to ensure that operator performance and reliability are supported. The NRC is developing guidance to support its review of these advanced designs. The guidance consists of an evaluation methodology and an extensive set of human factors guidelines which are used in one aspect of the evaluation. The paper describes the guidance development of the evaluation methodology and the guidelines.

  6. Implementation Plan for the Hawaii Geothermal Project Environmental Impact Statement (DOE Review Draft:)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-09-18

    The US Department of Energy (DOE) is preparing an Environmental Impact Statement (EIS) that identifies and evaluates the environmental impacts associated with the proposed Hawaii Geothermal Project (HGP), as defined by the State of Hawaii in its 1990 proposal to Congress (DBED 1990). The location of the proposed project is shown in Figure 1.1. The EIS is being prepared pursuant to the requirements of the National Environmental Policy Act of 1969 (NEPA), as implemented by the President's Council on Environmental Quality (CEQ) regulations (40 CFR Parts 1500-1508) and the DOE NEPA Implementing Procedures (10 CFR 1021), effective May 26, 1992. The State's proposal for the four-phase HGP consists of (1) exploration and testing of the geothermal resource beneath the slopes of the active Kilauea volcano on the Island of Hawaii (Big Island), (2) demonstration of deep-water power cable technology in the Alenuihaha Channel between the Big Island and Mau, (3) verification and characterization of the geothermal resource on the Big Island, and (4) construction and operation of commercial geothermal power production facilities on the Big Island, with overland and submarine transmission of electricity from the Big Island to Oahu and possibly other islands. DOE prepared appropriate NEPA documentation for separate federal actions related to Phase 1 and 2 research projects, which have been completed. This EIS will consider Phases 3 and 4, as well as reasonable alternatives to the HGP. Such alternatives include biomass coal, solar photovoltaic, wind energy, and construction and operation of commercial geothermal power production facilities on the Island of Hawaii (for exclusive use on the Big Island). In addition, the EIs will consider the reasonable alternatives among submarine cable technologies, geothermal extraction, production, and power generating technologies; pollution control technologies; overland and submarine power transmission routes; sites reasonably suited to

  7. Cyclic imines: chemistry and mechanism of action: a review.

    Science.gov (United States)

    Otero, Alberto; Chapela, María-José; Atanassova, Miroslava; Vieites, Juan M; Cabado, Ana G

    2011-11-21

    In recent years, there has been an increase in the production of shellfish and in global demand for seafood as nutritious and healthy food. Unfortunately, a significant number of incidences of shellfish poisoning occur worldwide, and microalgae that produce phycotoxins are responsible for most of these. Phycotoxins include several groups of small to medium sized natural products with molecular masses ranging from 300 to over 3000 Da. Cyclic imines (CIs) are a recently discovered group of marine biotoxins characterized by their fast acting toxicity, inducing a characteristic rapid death in the intraperitoneal mouse bioassay. These toxins are macrocyclic compounds with imine (carbon-nitrogen double bond) and spiro-linked ether moieties. They are grouped together due to the imino group functioning as their common pharmacore and due to the similarities in their intraperitoneal toxicity in mice. Spirolides (SPXs) are the largest group of CIs cyclic imines that together with gymnodimines (GYMs) are best characterized. Although the amount of cyclic imines in shellfish is not regulated and these substances have not been categorically linked to human intoxication, they trigger high intraperitoneal toxicity in rodents. In this review, the corresponding chemical structures of each member of the CIs and their derivatives are reviewed as well as all the data accumulated on their mechanism of action at cellular level.

  8. State of Georgia Appeals Council Request for Review Actions 2009 - 2014

    Data.gov (United States)

    Social Security Administration — This report contains the number of requests for review (RR) actions taken by the Appeals Council (AC) during the period indicated. These numbers of AC actions are...

  9. 78 FR 44117 - Notice of a Public Comment Period on the Draft IRIS Carcinogenicity Assessment for Ethylene Oxide

    Science.gov (United States)

    2013-07-23

    ... AGENCY Notice of a Public Comment Period on the Draft IRIS Carcinogenicity Assessment for Ethylene Oxide... Carcinogenicity of Ethylene Oxide'' (EPA/635/R-13/128a) and on the draft peer review charge questions. The draft... on the draft Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide and on the draft peer...

  10. 76 FR 33752 - Notice of Availability of the External Review Draft of the Guidance for Applying Quantitative...

    Science.gov (United States)

    2011-06-09

    ..., viewpoint, or determination. Members of the public may obtain the draft interim guidance from http://www... available online at http://www.regulations.gov , including any personal information provided, unless the... default uncertainty factor values for inter- and intraspecies extrapolation in health risk assessment. The...

  11. Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment (External Review Draft)

    Science.gov (United States)

    This draft report provides an overview of the types of mechanisms underlying the lymphohematopoietic cancers induced by chemical agents and radiation in humans, with a primary emphasis on leukemia and leukemia-inducing agents. It focuses on how mechanistic information on human l...

  12. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Public Comment Draft)

    Science.gov (United States)

    EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database.

  13. 76 FR 59155 - Notice of Availability of South Coast Draft Resource Management Plan Revision and Draft...

    Science.gov (United States)

    2011-09-23

    ... Bureau of Land Management Notice of Availability of South Coast Draft Resource Management Plan Revision and Draft Environmental Impact Statement AGENCY: Bureau of Land Management, Interior. ACTION: Notice... amended, and the Federal Land Policy and Management Act of 1976, as amended, the Bureau of Land Management...

  14. 76 FR 62087 - Draft Conservation Plan and Draft Environmental Assessment; Dunes Sagebrush Lizard, Texas

    Science.gov (United States)

    2011-10-06

    ... Lizard, Texas AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability; announcement... application includes the draft Texas Conservation Plan for the Dunes Sagebrush Lizard (TCP). The draft TCP... Service (Service) and the Applicant for the dunes sagebrush lizard (Sceloporus arenicolus) throughout...

  15. Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review

    Directory of Open Access Journals (Sweden)

    Sin-Yeang Teow

    2016-01-01

    Full Text Available Curcumin, the major constituent of Curcuma longa L. (Zingiberaceae family or turmeric, commonly used for cooking in Asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. Curcumin is found to be effective against Staphylococcus aureus (S. aureus. As demonstrated by in vitro experiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. Hence, curcumin which is a natural product derived from plant is believed to have profound medicinal benefits and could be potentially developed into a naturally derived antibiotic in the future. However, there are several noteworthy challenges in the development of curcumin as a medicine. S. aureus infections, particularly those caused by the multidrug-resistant strains, have emerged as a global health issue and urgent action is needed. This review focuses on the antibacterial activities of curcumin against both methicillin-sensitive S. aureus (MSSA and methicillin-resistant S. aureus (MRSA. We also attempt to highlight the potential challenges in the effort of developing curcumin into a therapeutic antibacterial agent.

  16. Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review

    Science.gov (United States)

    Liew, Kitson; Ali, Syed A.; Khoo, Alan Soo-Beng; Peh, Suat-Cheng

    2016-01-01

    Curcumin, the major constituent of Curcuma longa L. (Zingiberaceae family) or turmeric, commonly used for cooking in Asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. Curcumin is found to be effective against Staphylococcus aureus (S. aureus). As demonstrated by in vitro experiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. Hence, curcumin which is a natural product derived from plant is believed to have profound medicinal benefits and could be potentially developed into a naturally derived antibiotic in the future. However, there are several noteworthy challenges in the development of curcumin as a medicine. S. aureus infections, particularly those caused by the multidrug-resistant strains, have emerged as a global health issue and urgent action is needed. This review focuses on the antibacterial activities of curcumin against both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). We also attempt to highlight the potential challenges in the effort of developing curcumin into a therapeutic antibacterial agent. PMID:27956904

  17. 76 FR 9210 - Draft DOC National Aquaculture Policy

    Science.gov (United States)

    2011-02-16

    ... DOC National Aquaculture Policy AGENCY: Commerce. ACTION: Notice of availability of draft aquaculture... draft national aquaculture policy that supports sustainable aquaculture in the United States. The intent of the policy is to guide DOC's actions and decisions on aquaculture and to provide a...

  18. 77 FR 48995 - Draft National Toxicology Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes...

    Science.gov (United States)

    2012-08-15

    ... HUMAN SERVICES National Institutes of Health Draft National Toxicology Program (NTP) Monograph on... of the draft monograph. Topic: Peer review of the draft NTP Monograph on Developmental Effects and... scheduled for oral public comment. The NTP also invites written comments on the draft monograph, submission...

  19. 47 CFR 1.115 - Application for review of action taken pursuant to delegated authority.

    Science.gov (United States)

    2010-10-01

    ... to delegated authority. 1.115 Section 1.115 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Actions Taken by the Commission and Pursuant to Delegated Authority; Effective Dates and Finality Dates of Actions § 1.115 Application for review of action taken pursuant to delegated authority. (a) Any person...

  20. 45 CFR 160.312 - Secretarial action regarding complaints and compliance reviews.

    Science.gov (United States)

    2010-10-01

    ... Investigations § 160.312 Secretarial action regarding complaints and compliance reviews. (a) Resolution when... compliance or a completed corrective action plan or other agreement. (2) If the matter is resolved by... 45 Public Welfare 1 2010-10-01 2010-10-01 false Secretarial action regarding complaints...

  1. 42 CFR 3.312 - Secretarial action regarding complaints and compliance reviews.

    Science.gov (United States)

    2010-10-01

    ... Program § 3.312 Secretarial action regarding complaints and compliance reviews. (a) Resolution when... include demonstrated compliance or a completed corrective action plan or other agreement. (2) If the... 42 Public Health 1 2010-10-01 2010-10-01 false Secretarial action regarding complaints...

  2. Action Research in Graduate Teacher Education: A Review of the Literature 2000-2015

    Science.gov (United States)

    Vaughan, Michelle; Burnaford, Gail

    2016-01-01

    This review explores the goals and challenges as well as the policy and programmatic implications of action research in graduate teacher education as evidenced in the published literature. This literature review looks specifically at how action research is being used in graduate teacher education programs as a content area and as a methodology in…

  3. 75 FR 41452 - Draft Guidance, “Federal Greenhouse Gas Accounting and Reporting”

    Science.gov (United States)

    2010-07-16

    ... Leadership in Environmental, Energy, and Economic Performance (74 FR 52117) in order to establish an... QUALITY Draft Guidance, ``Federal Greenhouse Gas Accounting and Reporting'' AGENCY: Council on Environmental Quality. ACTION: Notice of Availability, Draft Guidance, ``Federal Greenhouse Gas Accounting...

  4. 76 FR 51034 - Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy...

    Science.gov (United States)

    2011-08-17

    ... HUMAN SERVICES Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer... Monograph AGENCY: Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health. ACTION: Availability of Draft Monograph; Request...

  5. Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (2011 Interagency Science Discussion Draft)

    Science.gov (United States)

    On September 22, 2006, the draft Evaluation of the Carinogenicity of Ethylene Oxide (EPA/635/R-06/003) and the draft charge to external peer reviewers were released for external peer review and public comment. This draft was reviewed by EPA’s Science Advisory Board (SAB)...

  6. Peer-review study of the draft handbook for human-reliability analysis with emphasis on nuclear-power-plant applications, NUREG/CR-1278

    Energy Technology Data Exchange (ETDEWEB)

    Brune, R. L.; Weinstein, M.; Fitzwater, M. E.

    1983-01-01

    This report describes a peer review of the draft Handbook for Human Reliability Analysis with Emphasis on Nuclear Power Plant Applications, NUREG/CR-1278. The purpose of the study was to determine to what extent peers agree with the human behavior models and estimates of human error probabilities (HEPs) contained in the Handbook. Twenty-nine human factors experts participated in the study. Twenty of the participants were Americans; nine were from other countries. The peers performed human reliability analyses of a variety of human performance scenarios describing operator activities in nuclear power plant settings. They also answered questionnaires pertaining to the contents and application of the Handbook. An analysis of peer solutions to the human reliability analysis problems and peer responses to the questionnaire was performed. Recommendations regarding the format and contents of the Handbook were developed from the study findings.

  7. Therapeutic Hypothermia: Critical review of the molecular mechanisms of action.

    Directory of Open Access Journals (Sweden)

    Fernando Pavel Gonzalez-Ibarra

    2011-02-01

    Full Text Available Therapeutic Hypothermia (TH is nowadays one of the most important methods of neuroprotection. The events that occur after an episode of ischemia are multiple and hypothermia can affect the various steps of this cascade. The mechanisms of action of TH are varied and the possible explanation for the benefits of this therapy is probably the multiple mechanisms of action blocking the cascade of ischemia on many levels. TH can affect many metabolic pathways, reactions of inflammation, apoptosis processes and promote neuronal integrity. To know the mechanisms of action of TH will allow a better understanding about the indications for this therapy and the possibility of searching for other therapies when used in conjunction with hypothermia will provide a therapeutic synergistic effect.

  8. 75 FR 43537 - Mortgagee Review Board: Administrative Actions

    Science.gov (United States)

    2010-07-26

    .... 1st Advantage Mortgage LLC, Lombard, IL. 2. 1st Alliance Banc Corporation, Chicago, IL. 3. 1st America.../b/a Lend America, Melville, NY Action: On November 30, 2009, the Board issued a Notice of... for the Northern District of Illinois on June 23, 2009, when he was charged with one count of bank...

  9. Resistance to aspirin: prevalence, mechanisms of action and association with thromboembolic events. A narrative review

    National Research Council Canada - National Science Library

    Cañivano Petreñas, L; García Yubero, C

    2010-01-01

    The purpose of this study is to review the prevalence of aspirin resistance in patients with a high risk of cardiovascular events, and secondly, to investigate its epidemiology and mechanism of action...

  10. Action Researchers Encountering Ethical Review: A Literature Synthesis on Challenges and Strategies

    Science.gov (United States)

    Fouché, Christa B.; Chubb, Laura A.

    2017-01-01

    Action research (AR) comprises a diverse family of methodologies. Common amongst most types of AR are both an emergent design--leading to action or change--and participation or community involvement. While this type of research has expanded considerably since the early 2000s, the criteria used for ethical review have apparently been slow to adapt…

  11. Feature integration across multimodal perception and action: a review.

    Science.gov (United States)

    Zmigrod, Sharon; Hommel, Bernhard

    2013-01-01

    The human brain is facing a continuous stream of stimulus information delivered by multiple modalities and sensory channels and processed in distinct cortical regions. We discuss recent empirical and theoretical developments in addressing the question of how this distributed information is integrated into coherent representations (the so-called binding problem) with an emphasis on the principles and constraints underlying the integration of multiple (rather than redundant) features across different sensory modalities and across perception and action planning.

  12. Five-Year Review of CERCLA Response Actions at the Idaho National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    W. L. Jolley

    2007-02-01

    This report summarizes the documentation submitted in support of the five-year review or remedial actions implemented under the Comprehensive Environmental Response, Compensation, and Liability Act Sitewide at the Idaho National Laboratory. The report also summarizes documentation and inspections conducted at the no-further-action sites. This review covered actions conducted at 9 of the 10 waste area groups at the Idaho National Laboratory, i.e. Waste Area Groups 1, 2, 3, 4, 5, 6, 7, 9, and 10. Waste Area Group 8 was not subject to this review, because it does not fall under the jurisdiction of the U.S. Department of Energy Idaho Operations Office. The review included past site inspections and monitoring data collected in support of the remedial actions. The remedial actions have been completed at Waste Area Groups 2, 4, 5, 6, and 9. Remedial action reports have been completed for Waste Area Groups 2 and 4, and remedial action reports are expected to be completed during 2005 for Waste Area Groups 1, 5, and 9. Remediation is ongoing at Waste Area Groups 3, 7, and 10. Remedial investigations are yet to be completed for Operable Units 3-14, 7-13/14, and 10-08. The review showed that the remedies have been constructed in accordance with the requirements of the Records of Decision and are functioning as designed. Immediate threats have been addressed, and the remedies continue to be protective. Potential short-term threats are being addressed though institutional controls. Soil cover and cap remedies are being maintained properly and inspected in accordance with the appropriate requirements. Soil removal actions and equipment or system removals have successfully achieved remedial action objectives identified in the Records of Decision. The next Sitewide five-year review is scheduled for completion by 2011.

  13. 77 FR 47373 - Fiscal Year 2012 Draft Work Plan; Correction

    Science.gov (United States)

    2012-08-08

    ... Year 2012 Draft Work Plan; Correction AGENCY: Denali Commission. ACTION: Notice; second correction..., concerning request for comments on the Draft Work Plan for Federal Fiscal Year 2012. This revision to Fiscal Year 2012 Work Plan is to provide clarifying edits. In particular, Section 304(b)(3) of the...

  14. 77 FR 69619 - Draft Recommendations of Joint Outreach Team

    Science.gov (United States)

    2012-11-20

    ... flexible grid while reducing costs to consumers, Western and DOE formed the JOT. The team conducted a... Area Power Administration Draft Recommendations of Joint Outreach Team AGENCY: Western Area Power Administration, DOE. ACTION: Notice of Availability of draft recommendations of Western/DOE Joint Outreach...

  15. 77 FR 66621 - Draft Guidance for Industry on Bioequivalence Recommendation for Lenalidomide Capsules; Availability

    Science.gov (United States)

    2012-11-06

    ... for Lenalidomide Capsules; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... lenalidomide capsules. The draft guidance is a revised version of a previously published draft guidance on the... availability of revised draft BE recommendations for lenalidomide capsules. Revlimid (lenalidomide capsules...

  16. 76 FR 174 - NIJ Draft Metal Detector Standards for Public Safety

    Science.gov (United States)

    2011-01-03

    ... of Justice Programs NIJ Draft Metal Detector Standards for Public Safety AGENCY: National Institute of Justice. ACTION: Notice and request for comments on the Draft Metal Detector Standards for Public... the following draft standards for metal detectors: 1. Walk-through Metal Detector Standard for...

  17. 77 FR 47435 - Prime Hook National Wildlife Refuge, Sussex County, DE; Draft Comprehensive Conservation Plan and...

    Science.gov (United States)

    2012-08-08

    ... Fish and Wildlife Service Prime Hook National Wildlife Refuge, Sussex County, DE; Draft Comprehensive Conservation Plan and Environmental Impact Statement AGENCY: Fish and Wildlife Service, Interior. ACTION... conservation plan and draft environmental impact statement (draft CCP/EIS) for Prime Hook National...

  18. 78 FR 33447 - Draft Applications for Sealed Source and Device Evaluation and Registration

    Science.gov (United States)

    2013-06-04

    ... Regulatory Commission. ACTION: Draft NUREG; request for comments. SUMMARY: The U.S. Nuclear Regulatory... and registration. The NRC is requesting public comment on draft NUREG-1556, Volume 3, Revision 2...@nrc.gov . The draft NUREG-1556, Volume 3, Revision 2, is available under ADAMS Accession...

  19. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Science.gov (United States)

    2010-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under § 270.110(a...

  20. Modelling polymer draft gears

    Science.gov (United States)

    Wu, Qing; Yang, Xiangjian; Cole, Colin; Luo, Shihui

    2016-09-01

    This paper developed a new and simple approach to model polymer draft gears. Two types of polymer draft gears were modelled and compared with experimental data. Impact characteristics, in-train characteristics and frequency responses of these polymer draft gears were studied and compared with those of a friction draft gear. The impact simulations show that polymer draft gears can withstand higher impact speeds than the friction draft gear. Longitudinal train dynamics simulations show that polymer draft gears have significantly longer deflections than friction draft gears in normal train operations. The maximum draft gear working velocities are lower than 0.2 m/s, which are significantly lower than the impact velocities during shunting operations. Draft gears' in-train characteristics are similar to their static characteristics but are very different from their impact characteristics; this conclusion has also been reached from frequency response simulations. An analysis of gangway bridge plate failures was also conducted and it was found that they were caused by coupler angling behaviour and long draft gear deflections.

  1. ICLUS Tools and Datasets (Version 1.2) and User's Manual: Arcgis Tools and Datasets for Modeling US Housing Density (External Review Draft)

    Science.gov (United States)

    This draft Geographic Information System (GIS) tool can be used to generate scenarios of housing-density changes and calculate impervious surface cover for the conterminous United States. A draft User’s Guide accompanies the tool. This product distributes the population project...

  2. Literature Review on the Use of Action Research in Higher Education

    Science.gov (United States)

    Gibbs, Paul; Cartney, Patricia; Wilkinson, Kate; Parkinson, John; Cunningham, Sheila; James-Reynolds, Carl; Zoubir, Tarek; Brown, Venetia; Barter, Phil; Sumner, Pauline; MacDonald, Angus; Dayananda, Asanka; Pitt, Alexandra

    2017-01-01

    This literature review considers the use of action research in higher education. The review specifically looks at two areas of higher education activity. The first concerns academic teaching practice and includes a discussion of research and pedagogy practice, and staff development. The second considers student engagement. In both of these core…

  3. Inhibition of Action, Thought, and Emotion: A Selective Neurobiological Review

    OpenAIRE

    Dillon, Daniel; Pizzagalli, Diego

    2007-01-01

    The neural bases of inhibitory function are reviewed, covering data from paradigms assessing inhibition of motor responses (antisaccade, go/nogo, stop-signal), cognitive sets (e.g., Wisconsin Card Sort Test), and emotion (fear extinction). The frontal cortex supports performance on these paradigms, but the specific neural circuitry varies: response inhibition depends upon fronto-basal ganglia networks, inhibition of cognitive sets is supported by orbitofrontal cortex, and retention of fear ex...

  4. How to Trick Your Opponent: A Review Article on Deceptive Actions in Interactive Sports

    Directory of Open Access Journals (Sweden)

    Iris Güldenpenning

    2017-05-01

    Full Text Available Performing deceptive actions is a wide-spread phenomenon in sports and it is of considerable practical relevance to know whether or not a fake or a disguised action decreases the opponents’ performance. Therefore, research on deceptive actions for various sport disciplines (e.g., cricket, rugby, martial arts, soccer, and basketball has been conducted. This research is scattered, both across time and scientific disciplines. Here, we aim to systematically review the empirical work on deceptive actions in interactive sports and want to give an overview about several issues investigated in the last decades. Three main topics of the detected literature were discussed here: (1 the role of expertise for the recognition of deceptive actions, (2 the cognitive mechanisms underlying the processing of deceptive actions, and (3 the pros and cons of in situ research designs. None of these themes seems to be settled and therefore, they should be considered in future research agendas.

  5. Bioinformatics Training: A Review of Challenges, Actions and Support Requirements

    DEFF Research Database (Denmark)

    Schneider, M.V.; Watson, J.; Attwood, T.;

    2010-01-01

    As bioinformatics becomes increasingly central to research in the molecular life sciences, the need to train non-bioinformaticians to make the most of bioinformatics resources is growing. Here, we review the key challenges and pitfalls to providing effective training for users of bioinformatics...... services, and discuss successful training strategies shared by a diverse set of bioinformatics trainers. We also identify steps that trainers in bioinformatics could take together to advance the state of the art in current training practices. The ideas presented in this article derive from the first...

  6. Draft audit report, human factors engineering control room design review: Saint Lucie Nuclear Power Plant, Unit No. 2

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, L.R.; Lappa, D.A.; Moore, J.W.

    1981-09-03

    A human factors engineering preliminary design review of the Saint Lucie Unit 2 control room was performed at the site on August 3 through August 7, 1981. This design review was carried out by a team from the Human Factors Engineering Branch, Division of Human Factors Safety. This report was prepared on the basis of the HFEB's review of the applicant's Preliminary Design Assessment and the human factors engineering design review/audit performed at the site. The review team included human factors consultants from BioTechnology, Inc., Falls Church, Virginia, and from Lawrence Livermore National Laboratory (University of California), Livermore, California.

  7. A Critical Review of Mode of Action (MOA) Assignment ...

    Science.gov (United States)

    There are various structure-based classification schemes to categorize chemicals based on mode of action (MOA) which have been applied for both eco and human health toxicology. With increasing calls to assess thousands of chemicals, some of which have little available information other than structure, clear understanding how each of these MOA schemes was devised, what information they are based on, and the limitations of each approach is critical. Several groups are developing low-tier methods to more easily classify or assess chemicals, using approaches such as the ecological threshold of concern (eco-TTC) and chemical-activity. Evaluation of these approaches and determination of their domain of applicability is partly dependent on the MOA classification that is used. The most commonly used MOA classification schemes for ecotoxicology include Verhaar and Russom (included in ASTER), both of which are used to predict acute aquatic toxicity MOA. Verhaar is a QSAR-based system that classifies chemicals into one of 4 classes, with a 5th class specified for those chemicals that are not classified in the other 4. ASTER/Russom includes 8 classifications: narcotics (3 groups), oxidative phosphorylation uncouplers, respiratory inhibitors, electrophiles/proelectrophiles, AChE inhibitors, or CNS seizure agents. Other methodologies include TEST (Toxicity Estimation Software Tool), a computational chemistry-based application that allows prediction to one of 5 broad MOA

  8. Reviewing Biosphere Reserves globally: effective conservation action or bureaucratic label?

    Science.gov (United States)

    Coetzer, Kaera L; Witkowski, Edward T F; Erasmus, Barend F N

    2014-02-01

    The Biosphere Reserve (BR) model of UNESCO's Man and the Biosphere Programme reflects a shift towards more accountable conservation. Biosphere Reserves attempt to reconcile environmental protection with sustainable development; they explicitly acknowledge humans, and human interests in the conservation landscape while still maintaining the ecological values of existing protected areas. Conceptually, this model is attractive, with 610 sites currently designated globally. Yet the practical reality of implementing dual 'conservation' and 'development' goals is challenging, with few examples successfully conforming to the model's full criteria. Here, we review the history of Biosphere Reserves from first inception in 1974 to the current status quo, and examine the suitability of the designation as an effective conservation model. We track the spatial expansion of Biosphere Reserves globally, assessing the influence of the Statutory Framework of the World Network of Biosphere Reserves and Seville strategy in 1995, when the BR concept refocused its core objectives on sustainable development. We use a comprehensive range of case studies to discuss conformity to the Programme, the social and ecological consequences associated with implementation of the designation, and challenges in aligning conservation and development. Given that the 'Biosphere Reserve' label is a relatively unknown designation in the public arena, this review also provides details on popularising the Biosphere Reserve brand, as well as prospects for further research, currently unexploited, but implicit in the designation.

  9. Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 124: Storage Tanks, Nevada Test Site, Nevada (Draft), Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Alfred Wickline

    2007-04-01

    This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses closure for Corrective Action Unit (CAU) 124, Areas 8, 15, and 16 Storage Tanks, identified in the Federal Facility Agreement and Consent Order. Corrective Action Unit 124 consists of five Corrective Action Sites (CASs) located in Areas 8, 15, and 16 of the Nevada Test Site as follows: • 08-02-01, Underground Storage Tank • 15-02-01, Irrigation Piping • 16-02-03, Underground Storage Tank • 16-02-04, Fuel Oil Piping • 16-99-04, Fuel Line (Buried) and UST This plan provides the methodology of field activities necessary to gather information to close each CAS. There is sufficient information and process knowledge from historical documentation and investigations of similar sites regarding the expected nature and extent of potential contaminants to recommend closure of CAU 124 using the SAFER process.

  10. Massage therapy: understanding the mechanisms of action on blood pressure. A scoping review.

    Science.gov (United States)

    Nelson, Nicole L

    2015-10-01

    Massage therapy (MT) has shown potential in reducing blood pressure (BP); however, the psychophysiological pathways and structures involved in this outcome are unclear. The aims of this scoping review were twofold. (1) To summarize the current knowledge of the mechanisms of action of MT on BP. (2) To highlight the research gaps and challenges that researchers must overcome to further elucidate how MT attenuates BP. A scoping review was conducted to examine the evidence regarding the mechanisms of action of MT on BP. This review included the thematic analysis of 27 publications that considered the influence of MT on BP. Based on this analysis, six potential BP mediating pathways were identified Current theories suggest that MT exerts sympatholytic effects through physiologic and psychological mechanisms, improves hypothalamus-pituitary-adrenocortical axis function, and increases in blood flow, which, in turn, may improve endothelial function. Future study is needed, using more scientifically rigorous methodology, to fully elucidate the mechanism of action of MT.

  11. EU-stress test: Swiss national action plan. Follow-up of peer review 2012 year-end status report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-12-15

    The European Union (EU) stress test is part of the review process which Switzerland initiated immediately after the reactor accident in Japan. As a direct consequence of the accident, the Swiss Federal Nuclear Safety Inspectorate (ENSI) issued three formal orders in which the operators of the Swiss nuclear power plants (NPPs) were required to implement immediate measures and to conduct additional reassessments. The immediate measures comprised the establishment of an external emergency storage facility for the Swiss NPPs, including the necessary plant-specific connections, and back-fittings to provide external injection into the spent fuel pools. The additional reassessments focused on the design of the Swiss NPPs against earthquakes, external flooding and a combination thereof. Investigations on the coolant supply for the safety systems and the spent fuel pool cooling were also requested. ENSI carried out an analysis of the events at Fukushima providing detailed descriptions of the causes, consequences and radiological impacts of the accident. The reports analyse the contributory human and organisational factors, and specify lessons that can be derived from this information. ENSI instructed the Swiss operators to take part in the EU stress test. There was to be particular examination of the robustness of the NPPs in case of impacts beyond the design basis due to earthquakes, external flooding and extreme weather conditions, with consequential loss of power supply and heat sink, and the need for severe accident management actions. ENSI requested further clarification on plant specific issues and produced the National Report which was delivered to the EU Commission. A Country Peer Review Draft Report was drawn up for each country, including a list of issues (open points) for further follow-up by the review team. Eight new open points were identified to further improve the safety of the Swiss NPPs. These open points together with the issues identified in the analysis

  12. Review of standards and guidelines pertinent to DOE's remedial action programs

    Energy Technology Data Exchange (ETDEWEB)

    Soldat, J.K.; Denham, D.H.

    1984-10-01

    A number of radiological standards, guidelines, and dose criteria have been promulgated that may be relevant to the Department of Energy's (DOE) Remedial Action programs. Some of these will be applied to remedial actions undertaken by DOE to ensure that health and safety aspects will be adequately addressed. Pacific Northwest Laboratory staff are reviewing and evaluating existing and proposed environmental radiological standards and criteria for their applicability. National and international environmental standards and criteria, and studies conducted by other DOE contractors are being evaluated. The aim of the review is to identify gaps in these standards and guidelines and to recommend further development as necessary. This paper provides a summary of the standards and guidelines evaluated for applicability to DOE's Remedial Action programs. 33 references, 5 tables.

  13. TQM (Total Quality Management) SPARC (Special Process Action Review Committees) Handbook

    Science.gov (United States)

    1989-08-01

    improvement; Logistics information; Process analysis; Quality control; Quality assurance; Total Quality Management ; Statistical processes; Management Planning and control; Management training; Management information systems.... Quality Management (TQM). It includes concepts and definitions, checklists, sample formats, and assessment criteria. Keywords: Continuous process...This document describes the techniques used to support and guide the Special Process Action Review Committees for accomplishing their goals for Total

  14. 7 CFR 246.18 - Administrative review of State agency actions.

    Science.gov (United States)

    2010-01-01

    ... competitive price (§ 246.12(g)(4)); (C) The application of the State agency's vendor peer group criteria and... not limited to, vendor peer group criteria and the criteria used to identify vendors that are above-50... 7 Agriculture 4 2010-01-01 2010-01-01 false Administrative review of State agency actions....

  15. Basic Drafting: Book Two.

    Science.gov (United States)

    Davis, Ronald; And Others

    The second of a two-book course in drafting, this manual consists of 12 topics in the following units: sketching techniques, geometric constructions, orthographic views, dimensioning procedures, basic tolerancing, auxiliary views, sectional views, inking tools and techniques, axonometrics, oblique, perspective, and computer-aided drafting.…

  16. Development of a Relative Potency Factor (Rpf) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft)

    Science.gov (United States)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of polycyclic aromatic hydrocarbon (PAH) mixtures that when finalized will appear on the Integrated Risk Information System (IRIS) database. ...

  17. Assessment of the Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking Water Resources (External Review Draft)

    Science.gov (United States)

    This assessment provides a review and synthesis of available scientific literature and data to assess the potential for hydraulic fracturing for oil and gas to impact the quality or quantity of drinking water resources, and identifies factors affecting the frequency or severity o...

  18. Dignity-conserving care actions in palliative care: an integrative review of Swedish research.

    Science.gov (United States)

    Harstäde, Carina Werkander; Blomberg, Karin; Benzein, Eva; Östlund, Ulrika

    2017-05-16

    Previous research has proposed that persons in need of palliative care often have a loss of functions and roles that affects social and existential self-image. Moreover, these individuals also commonly suffer from complex multisymptoms. This, together with the situation of facing an impending death, can lead to a loss of dignity. Therefore, supporting these persons' dignity is a crucial challenge for professional nurses. The 'Dignity Care Intervention' addresses the multidimensionality of dignity by identifying patients' dignity-related concerns and suggests care actions to address them. At the present, the Dignity Care Intervention is adapted for implementation in Swedish care settings. Because expressions of dignity are influenced by culture, and an overview of care actions in a Swedish context is lacking, this integrative review aimed to find suggestions from Swedish research literature on what kind of care actions can preserve dignity. An integrative literature review was conducted using the databases SwePub and SweMed+. Articles published from 2006 to 2015 and theses published from 2000 to 2015 were searched for using the terms 'dignity' and 'palliative care'. Result sections of articles and theses were reviewed for dignity-conserving care actions synthesised by thematic analysis and categorised under themes and subthemes in Chochinov's model of dignity. Fifteen articles and 18 theses were included together providing suggestions of care actions in all themes and subthemes in the dignity model. Suggested care actions included listening, communication, information, symptom control, facilitating daily living and including patients in decision-making. Additionally, nurses' perceptiveness towards the patients was a core approach. The review offers culturally relevant suggestions on how to address specific dignity-related concerns. The adapted Dignity Care Intervention will be a way for Swedish nurses to provide person-centred palliative care that will conserve

  19. 76 FR 9590 - Fisheries and Habitat Conservation and Migratory Birds Programs; Draft Land-Based Wind Energy...

    Science.gov (United States)

    2011-02-18

    ...; Draft Land-Based Wind Energy Guidelines AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of... comment of draft Wind Energy Guidelines (Guidelines). These draft Guidelines are intended to supersede the... intended to respond to accelerated development of land-based, wind energy generation projects in the...

  20. 76 FR 11506 - Fisheries and Habitat Conservation and Migratory Birds Programs; Draft Land-Based Wind Energy...

    Science.gov (United States)

    2011-03-02

    ...; Draft Land-Based Wind Energy Guidelines; Correction AGENCY: Fish and Wildlife Service, Interior. ACTION... comment of draft Land-Based Wind Energy Guidelines (Guidelines). We are issuing a correction to that... Land-Based Wind Energy Guidelines (Guidelines). These draft Guidelines do not supersede the...

  1. 76 FR 67764 - Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft...

    Science.gov (United States)

    2011-11-02

    ... Report for Comment AGENCY: Nuclear Regulatory Commission. ACTION: Draft NUREG; request for comment. ] SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment a draft NUREG, NUREG...-4209, (301) 415-4737, or by email to pdr.resource@nrc.gov . The draft NUREG is available...

  2. 75 FR 2145 - Notice of Availability of a Draft Environmental Impact Statement for the Construction of a New...

    Science.gov (United States)

    2010-01-14

    ... ADMINISTRATION Notice of Availability of a Draft Environmental Impact Statement for the Construction of a New..., announces the availability of a Draft Environmental Impact Statement (Draft EIS) assessing the potential.... ACTION: Notice of availability. SUMMARY: In accordance with the National Environmental Policy Act...

  3. Hypertrophic Effects of Concentric vs. Eccentric Muscle Actions: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Schoenfeld, Brad J; Ogborn, Dan I; Vigotsky, Andrew D; Franchi, Martino V; Krieger, James W

    2017-09-01

    Schoenfeld, BJ, Ogborn, DI, Vigotsky, AD, Franchi, MV, and Krieger, JW. Hypertrophic effects of concentric vs. eccentric muscle actions: A systematic review and meta-analysis. J Strength Cond Res 31(9): 2599-2608, 2017-Controversy exists as to whether different dynamic muscle actions produce divergent hypertrophic responses. The purpose of this paper was to conduct a systematic review and meta-analysis of randomized controlled trials comparing the hypertrophic effects of concentric vs. eccentric training in healthy adults after regimented resistance training (RT). Studies were deemed eligible for inclusion if they met the following criteria: (a) were an experimental trial published in an English-language refereed journal; (b) directly compared concentric and eccentric actions without the use of external implements (i.e., blood pressure cuffs) and all other RT variables equivalent; (c) measured morphologic changes using biopsy, imaging (magnetic resonance imaging, computerized tomography, or ultrasound), bioelectrical impedance, and/or densitometry; (d) had a minimum duration of 6 weeks; and (e) used human participants without musculoskeletal injury or any health condition that could directly, or through the medications associated with the management of said condition, be expected to impact the hypertrophic response to resistance exercise. A systematic literature search determined that 15 studies met inclusion criteria. Results showed that eccentric muscle actions resulted in a greater effect size (ES) compared with concentric actions, but results did not reach statistical significance (ES difference = 0.25 ± 0.13; 95% confidence interval: -0.03 to 0.52; p = 0.076). The mean percent change in muscle growth across studies favored eccentric compared with concentric actions (10.0% vs. 6.8, respectively). The findings indicate the importance of including eccentric and concentric actions in a hypertrophy-oriented RT program, as both have shown to be effective in

  4. Youth bullying: a review of the science and call to action.

    Science.gov (United States)

    Vessey, Judith A; DiFazio, Rachel L; Strout, Tania D

    2013-01-01

    Recognized as a critical public health problem, youth bullying is reportedly experienced by approximately 20% of today's youths. In the last decade, attention to bullying has increased and the scientific knowledge base relevant for practitioners who treat youths, research their issues, and create policy has expanded. The purpose of this review is to highlight key developments related to the health effects of bullying, interventions aimed at curbing bullying behaviors, the measurement of bullying, and nursing's disciplinary response to this phenomenon. A call to action for nurses involved in caring for youths across settings and roles is offered and strategic actions for nursing professionals are provided. Published by Mosby, Inc.

  5. Career Directions for Drafting CAD Technicians.

    Science.gov (United States)

    Moore, Pam

    2002-01-01

    Provides information careers for drafting/computer-assisted drafting technicians, including salaries, responsibilities, employment outlook, working conditions, skills needed, and career advancement opportunities. Lists professional drafting organizations. (JOW)

  6. 77 FR 55222 - Notice of Availability of the Draft Resource Management Plan Amendment and the Draft...

    Science.gov (United States)

    2012-09-07

    ..., recreation management, social and economic values, utility corridors, roads and travel management, and visual... Bureau of Land Management Notice of Availability of the Draft Resource Management Plan Amendment and the... Garfield, Moffat and Rio Blanco Counties, CO AGENCY: Bureau of Land Management, Interior. ACTION: Notice...

  7. 75 FR 13562 - Revised Draft Guidance for Industry on Pharmacokinetics in Patients With Impaired Renal Function...

    Science.gov (United States)

    2010-03-22

    ..., such as changes in absorption, plasma protein binding, transport, and tissue distribution. These... This draft guidance refers to previously approved collections of information that are subject to review...

  8. Choose Health Action Teens: A Review of a Teens as Teachers Nutritional Education Training Curriculum

    Directory of Open Access Journals (Sweden)

    Jeffrey M. Flesch

    2016-12-01

    Full Text Available This review draws from published research related to the best practices for the utilization of teens as teachers to examine Choose Health Action Teens (CHAT, a teen’s as teachers (TAT training curriculum.  Research shows that there are various components necessary to build a high quality TAT program.  Most of these components fall under four areas in which training is necessary for teens and adults: Teaching strategies, youth/child development, subject matter to be taught, and youth-adult partnerships.  These four areas provide a framework to review the Choose Health Action Teens (CHAT (Crosiar & Wolfe, 2013 teens as teachers training program curriculum.

  9. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

    OpenAIRE

    Visweswara Rao Pasupuleti; Lakhsmi Sammugam; Nagesvari Ramesh; Siew Hua Gan

    2017-01-01

    Background. There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. Scope and Approach. In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. Key Findings and Conclusions. An overview of honey, p...

  10. Proposed Approach for Reviewing Changes to Risk-Important Human Actions

    Science.gov (United States)

    2000-10-01

    controlling DoD office). £H^ NUREG /CR-6689 BNL- NUREG -52598 Proposed Approach for Reviewing Changes to Risk-Important Human Actions Brookhaven National...AVAILABILITY OF REFERENCE MATERIALS IN NRC PUBLICATIONS NRC Reference Material As of November 1999, you may electronically access NUREG -series...few, NUREG -series publications; Federal Register notices; applicant, licensee, and vendor documents and correspondence; NRC correspondence and

  11. Nanomaterial Case Study: A Comparison of Multiwalled Carbon Nanotube and Decabromodiphenyl Ether Flame-Retardant Coatings Applied to Upholstery Textiles (External Review Draft)

    Science.gov (United States)

    The draft document is intended to be used as part of a process to identify what is known and, more importantly, what is not yet known that could be of value in assessing the broad implications of specific nanomaterials. Like previous case studies (see History/ Chronology below), ...

  12. Nanomaterial Case Study: A Comparison of Multiwalled Carbon Nanotube and Decabromodiphenyl Ether Flame-Retardant Coatings Applied to Upholstery Textiles (External Review Draft)

    Science.gov (United States)

    The draft document is intended to be used as part of a process to identify what is known and, more importantly, what is not yet known that could be of value in assessing the broad implications of specific nanomaterials. Like previous case studies (see History/ Chronology below), ...

  13. Drafting: Current Trends and Future Practices

    Science.gov (United States)

    Jensen, C.

    1976-01-01

    Various research findings are reported on drafting trends which the author feels should be incorporated into teaching drafting: (1) true position and geometric tolerancing, (2) decimal and metric dimensioning, (3) functional drafting, (4) automated drafting, and (5) drawing reproductions. (BP)

  14. 76 FR 77829 - Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, Wyoming

    Science.gov (United States)

    2011-12-14

    ... Group, Inc. (ERG), an EPA contractor for external peer review, will convene an independent panel of experts for peer review of this draft research report. Public comments submitted during the public comment...-dissemination peer review. This draft research report has not been formally disseminated by EPA. It does...

  15. 45 CFR 60.10 - Reporting negative actions or findings taken by peer review organizations or private...

    Science.gov (United States)

    2010-10-01

    ... peer review organizations or private accreditation entities. 60.10 Section 60.10 Public Welfare... negative actions or findings taken by peer review organizations or private accreditation entities. (a) What..., dentist, or entity by a peer review organization or private accreditation entity. The health...

  16. A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin

    Directory of Open Access Journals (Sweden)

    Gaurang P Mavani

    2015-03-01

    Full Text Available The pressor and antidiuretic actions of arginine vasopressin (AVP have been well documented. This review focuses on the less widely appreciated actions of AVP which also have important physiologic functions and when better understood may provide important insights into common disease states. These actions include effects on pain perception and bone structure as well as important relationships to the varied components of metabolic syndrome. These include effects on blood glucose, lipid levels, and blood pressure. AVP may also play a role in the progression of chronic kidney disease and effect physiologic changes relating to aging, abnormal social behavior and cognitive function. Important cellular responses including cell proliferation, inflammation and control of infection and their relationship to AVP are described. Finally, the effects of AVP on hemostasis and the hypothalamic-pituitary-adrenal access are noted. The goal of this summary of the various actions of AVP is to direct attention to the potential benefits of research in these underemphasized areas of importance.

  17. A Review of the Nonpressor and Nonantidiuretic Actions of the Hormone Vasopressin

    Science.gov (United States)

    Mavani, Gaurang P.; DeVita, Maria V.; Michelis, Michael F.

    2015-01-01

    The pressor and antidiuretic actions of arginine vasopressin (AVP) have been well documented. This review focuses on the less widely appreciated actions of AVP which also have important physiologic functions and when better understood may provide important insights into common disease states. These actions include effects on pain perception and bone structure as well as important relationships to the varied components of metabolic syndrome. These include effects on blood glucose, lipid levels, and blood pressure. AVP may also play a role in the progression of chronic kidney disease and effect physiologic changes relating to aging, abnormal social behavior, and cognitive function. Important cellular responses including cell proliferation, inflammation, and control of infection and their relationship to AVP are described. Finally, the effects of AVP on hemostasis and the hypothalamic–pituitary–adrenal axis are noted. The goal of this summary of the various actions of AVP is to direct attention to the potential benefits of research in these underemphasized areas of importance. PMID:25853137

  18. Computer Assisted Drafting (CNC) Drawings. Drafting Module 6. Instructor's Guide.

    Science.gov (United States)

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. This unit contains information on computer-assisted drafting drawings. The guide contains a cross-reference table of instructional materials and 20 worksheets.…

  19. Computer Assisted Drafting (CNC) Drawings. Drafting Module 6. Instructor's Guide.

    Science.gov (United States)

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. This unit contains information on computer-assisted drafting drawings. The guide contains a cross-reference table of instructional materials and 20 worksheets.…

  20. Actions, topological terms and boundaries in first order gravity: A review

    CERN Document Server

    Corichi, Alejandro; Vukasinac, Tatjana

    2016-01-01

    In this review we consider first order gravity in four dimensions. In particular, we focus our attention in formulations where the fundamental variables are a tetrad $e_a^I$ and a SO(3,1) connection ${\\omega_{aI}}^J$. We study the most general action principle compatible with diffeomorphism invariance. This implies, in particular, considering besides the standard Einstein-Hilbert-Palatini term, other terms that either do not change the equations of motion, or are topological in nature. Having a well defined action principle sometimes involves the need for additional boundary terms, whose detailed form may depend on the particular boundary conditions at hand. In this work, we consider spacetimes that include a boundary at infinity, satisfying asymptotically flat boundary conditions and/or an internal boundary satisfying isolated horizons boundary conditions. We focus on the covariant Hamiltonian formalism where the phase space $\\Gamma$ is given by solutions to the equations of motion. For each of the possible ...

  1. Motor imagery during action observation: A brief review of evidence, theory and future research opportunities

    Directory of Open Access Journals (Sweden)

    Daniel Lloyd Eaves

    2016-11-01

    Full Text Available Motor imagery (MI and action observation (AO have traditionally been viewed as two separate techniques, which can both be used alongside physical practice to enhance motor learning and rehabilitation. Their independent use has been shown to be effective, and there is clear evidence that the two processes can elicit similar activity in the motor system. Building on these well-established findings, research has now turned to investigate the effects of their combined use. In this article, we first review the available neurophysiological and behavioral evidence for the effects of combined action observation and motor imagery (‘AO+MI’ on motor processes. We next describe a conceptual framework for their combined use, and then discuss several areas for future research into AO+MI processes. In this review, we advocate a more integrated approach to AO+MI techniques than has previously been adopted by movement scientists and practitioners alike. We hope this early review of an emergent body of research, along with a related set of research questions, can inspire new work in this area. We are optimistic that future research will further confirm if, how, and when this combined approach to AO+MI can be more effective in motor learning and rehabilitation settings, relative to the more traditional application of AO or MI independently.

  2. Development of a mental health action checklist for improving workplace environment as means of job stress prevention.

    Science.gov (United States)

    Yoshikawa, Toru; Kawakami, Norito; Kogi, Kazutaka; Tsutsumi, Akizumi; Shimazu, Miyuki; Nagami, Makiko; Shimazu, Akihito

    2007-07-01

    An action checklist for improving the workplace environment by means of enhancing mental health of workers (Mental Health Action Check List: MHACL) was developed. The use of the checklist for primary prevention was examined. MHACL was developed through three steps: (1) Review of related references and collection of improvement examples for designing a draft MHACL; (2) pilot application of the draft at industrial workplaces and trials at workshops of occupational health staff; and (3) proposing a new MHACL for general use in industry. Workplace improvement actions related to mental health were listed in eight technical areas. From 84 workplaces in Japan, 201 such actions were collected. Typical improvement action phrases were extracted based on these examples, and a draft MHACL containing 40 generally applicable actions were prepared. This draft was applied to selected workplaces for its use as a tool for group discussion. Then, the utility of the checklist was discussed by 105 occupational health staff working in public service offices. The workshop suggested modifications of the draft MHACL including improved check items and usage procedures and the need to use easy-to-understand actions. The final version of the MHACL comprised 30 items in six technical areas: A) sharing work planning, B) work time and organization, C) ergonomic work methods, D) workplace environment, E) mutual support in the workplace, and F) preparedness and care. A new action checklist was proposed for use as a means of changing existing workplace environments and proposing practical actions for improving it. The checklist was confirmed to be useful for organizing workplace-level discussion for identifying immediate improvements at the workplace. The checklist is expected to be widely applied for promoting primary prevention measures in terms of better mental health.

  3. 78 FR 20690 - Draft Environmental Impact Statement, Draft Habitat Conservation Plan, Draft Programmatic...

    Science.gov (United States)

    2013-04-05

    ... (MW). The 301.3-MW Fowler Phase I was constructed in 2008 and consists of 40 Clipper Liberty wind... addressed in the draft HCP or draft EIS; 3. Any new information on white-nose syndrome effects on...

  4. 76 FR 54502 - Energy Northwest, Columbia Generating Station; Notice of Availability of Draft Supplement 47 to...

    Science.gov (United States)

    2011-09-01

    ... COMMISSION Energy Northwest, Columbia Generating Station; Notice of Availability of Draft Supplement 47 to... Regulatory Commission (NRC) has published a draft plant-specific supplement to the Generic Environmental... renewal) include no action and reasonable alternative energy sources. Any interested party may...

  5. 77 FR 13139 - Malheur National Wildlife Refuge, Harney County, OR; Draft Comprehensive Conservation Plan and...

    Science.gov (United States)

    2012-03-05

    ... Fish and Wildlife Service Malheur National Wildlife Refuge, Harney County, OR; Draft Comprehensive Conservation Plan and Draft Environmental Impact Statement AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability. SUMMARY: We, the U.S. Fish and Wildlife Service (Service), announce...

  6. 76 FR 51395 - Draft Environmental Impact Statement for the General Management Plan (DEIS/GMP), Canaveral...

    Science.gov (United States)

    2011-08-18

    ... National Park Service Draft Environmental Impact Statement for the General Management Plan (DEIS/GMP... Draft Environmental Impact Statement for the General Management Plan (DEIS/GMP), Canaveral National...-Action Alternative that continues current management policies and the NPS's preferred alternative. The...

  7. 77 FR 12323 - Draft Environmental Impact Statement for the General Management Plan, Buck Island Reef National...

    Science.gov (United States)

    2012-02-29

    ... National Park Service Draft Environmental Impact Statement for the General Management Plan, Buck Island... Availability of a Draft Environmental Impact Statement for the General Management Plan (DEIS/GMP), Buck Island... alternatives for consideration, including a No-Action Alternative that continues current management policies...

  8. 78 FR 68469 - Draft General Management Plan/Wilderness Study/Environmental Impact Statement, Channel Islands...

    Science.gov (United States)

    2013-11-14

    ... National Park Service Draft General Management Plan/Wilderness Study/Environmental Impact Statement... availability of a Draft General Management Plan (GMP)/Wilderness Study/Environmental Impact Statement (EIS) for... action alternative) reflects current management direction and serves as a baseline for comparison with...

  9. 78 FR 47410 - General Management Plan, Draft Environmental Impact Statement, Gateway National Recreation Area...

    Science.gov (United States)

    2013-08-05

    ... National Park Service General Management Plan, Draft Environmental Impact Statement, Gateway National Recreation Area, New Jersey and New York AGENCY: National Park Service, Interior. ACTION: Notice of... National Park Service (NPS) is releasing a Draft Environmental Impact Statement (DEIS) for the...

  10. 75 FR 1656 - Draft Safety Culture Policy Statement: Request for Public Comments; Extension of Comment Period

    Science.gov (United States)

    2010-01-12

    ... COMMISSION Draft Safety Culture Policy Statement: Request for Public Comments; Extension of Comment Period AGENCY: Nuclear Regulatory Commission (NRC). ACTION: Issuance of draft safety culture policy statement and notice of opportunity for public comment; Extension of comment period. SUMMARY: On November...

  11. 78 FR 17943 - Draft Program-Specific Guidance About Fixed Gauge Licenses

    Science.gov (United States)

    2013-03-25

    .... ACTION: Draft NUREG; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is... NUREG-1556, Volume 4, Revision 1, ``Consolidated Guidance About Materials Licenses: Program-Specific...- 4737, or by email to pdr.resource@nrc.gov . The draft NUREG-1556, Volume 4, Revision 1, is available...

  12. 77 FR 12853 - Draft Guidances Relating to the Development of Biosimilar Products; Public Hearing; Request for...

    Science.gov (United States)

    2012-03-02

    ... biosimilar product development. We agree with this approach and have begun with the three draft guidance... HUMAN SERVICES Food and Drug Administration Draft Guidances Relating to the Development of Biosimilar Products; Public Hearing; Request for Comments AGENCY: Food and Drug Administration, HHS. ACTION: Notice...

  13. 77 FR 14401 - Draft Guidance on Drug Safety Information-FDA's Communication to the Public; Availability

    Science.gov (United States)

    2012-03-09

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance on Drug Safety Information--FDA's Communication to the Public; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... ``Drug Safety Information-- FDA's Communication to the Public.'' This draft guidance updates and...

  14. 77 FR 8262 - Draft Guidance on Investigational New Drug Applications for Positron Emission Tomography Drugs...

    Science.gov (United States)

    2012-02-14

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance on Investigational New Drug Applications for Positron Emission Tomography Drugs; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a draft...

  15. 78 FR 65978 - Draft Revised Strategic Plan for FY 2014-2018

    Science.gov (United States)

    2013-11-04

    ... SAFETY BOARD Draft Revised Strategic Plan for FY 2014-2018 AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice. SUMMARY: In accordance with Office of Management and Budget Circular No. A-11... potentially affected parties on its draft revised strategic plan. DNFSB will consider all comments received...

  16. 75 FR 57963 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Science.gov (United States)

    2010-09-23

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Helicobacter pylori; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of the draft guidance...

  17. 75 FR 65495 - Draft Guidance for Industry on Qualification Process for Drug Development Tools; Availability

    Science.gov (United States)

    2010-10-25

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Qualification Process for Drug Development Tools; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for...

  18. 78 FR 35959 - Notice of Availability of Draft Resource Management Plan and Associated Environmental Impact...

    Science.gov (United States)

    2013-06-14

    ..., land tenure adjustments, visual resource management, and climate change. The South Dakota draft RMP/EIS... Bureau of Land Management Notice of Availability of Draft Resource Management Plan and Associated... Land Management, Interior. ACTION: Notice of availability. SUMMARY: In accordance with the...

  19. 78 FR 11903 - Acceptability of Corrective Action Programs for Fuel Cycle Facilities

    Science.gov (United States)

    2013-02-20

    ... Commission. ACTION: Draft NUREG; request for public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is issuing for public comment draft NUREG-2154 ``Acceptability of Corrective Action Programs for Fuel Cycle Facilities.'' The draft NUREG provides guidance to the NRC staff on how to determine...

  20. Public Review Draft: A Method for Assessing Carbon Stocks, Carbon Sequestration, and Greenhouse-Gas Fluxes in Ecosystems of the United States Under Present Conditions and Future Scenarios

    Science.gov (United States)

    Bergamaschi, Brian A.; Bernknopf, Richard; Clow, David; Dye, Dennis; Faulkner, Stephen; Forney, William; Gleason, Robert; Hawbaker, Todd; Liu, Jinxun; Liu, Shu-Guang; Prisley, Stephen; Reed, Bradley; Reeves, Matthew; Rollins, Matthew; Sleeter, Benjamin; Sohl, Terry; Stackpoole, Sarah; Stehman, Stephen; Striegl, Robert G.; Wein, Anne; Zhu, Zhi-Liang; Zhu, Zhi-Liang

    2010-01-01

    The Energy Independence and Security Act of 2007 (EISA), Section 712, authorizes the U.S. Department of the Interior to develop a methodology and conduct an assessment of the Nation's ecosystems focusing on carbon stocks, carbon sequestration, and emissions of three greenhouse gases (GHGs): carbon dioxide, methane, and nitrous oxide. The major requirements include (1) an assessment of all ecosystems (terrestrial systems, such as forests, croplands, wetlands, shrub and grasslands; and aquatic ecosystems, such as rivers, lakes, and estuaries), (2) an estimation of annual potential capacities of ecosystems to increase carbon sequestration and reduce net GHG emissions in the context of mitigation strategies (including management and restoration activities), and (3) an evaluation of the effects of controlling processes, such as climate change, land use and land cover, and wildlfires. The purpose of this draft methodology for public review is to propose a technical plan to conduct the assessment. Within the methodology, the concepts of ecosystems, carbon pools, and GHG fluxes used for the assessment follow conventional definitions in use by major national and international assessment or inventory efforts. In order to estimate current ecosystem carbon stocks and GHG fluxes and to understand the potential capacity and effects of mitigation strategies, the method will use two time periods for the assessment: 2001 through 2010, which establishes a current ecosystem GHG baseline and will be used to validate the models; and 2011 through 2050, which will be used to assess future potential conditions based on a set of projected scenarios. The scenario framework is constructed using storylines of the Intergovernmental Panel on Climate Change (IPCC) Special Report Emission Scenarios (SRES), along with initial reference land-use and land-cover (LULC) and land-management scenarios. An additional three LULC and land-management mitigation scenarios will be constructed for each

  1. Antioxidant activity and mechanisms of action of natural compounds isolated from lichens: a systematic review.

    Science.gov (United States)

    White, Pollyanna A S; Oliveira, Rita C M; Oliveira, Aldeidia P; Serafini, Mairim R; Araújo, Adriano A S; Gelain, Daniel P; Moreira, Jose C F; Almeida, Jackson R G S; Quintans, Jullyana S S; Quintans-Junior, Lucindo J; Santos, Marcio R V

    2014-09-12

    Chronic diseases such as cancer, diabetes, neurodegenerative and cardiovascular diseases are characterized by an enhanced state of oxidative stress, which may result from the overproduction of reactive species and/or a decrease in antioxidant defenses. The search for new chemical entities with antioxidant profile is still thus an emerging field on ongoing interest. Due to the lack of reviews concerning the antioxidant activity of lichen-derived natural compounds, we performed a review of the antioxidant potential and mechanisms of action of natural compounds isolated from lichens. The search terms "lichens", "antioxidants" and "antioxidant response elements" were used to retrieve articles in LILACS, PubMed and Web of Science published until February 2014. From a total of 319 articles surveyed, 32 met the established inclusion and exclusion criteria. It was observed that the most common isolated compound studied was usnic acid, cited in 14 out of the 32 articles. The most often described antioxidant assays for the study of in vitro antioxidant activity were mainly DPPH, LPO and SOD. The most suggested mechanisms of action were scavenging of reactive species, enzymatic activation and inhibition of iNOS. Thus, compounds isolated from lichens are possible candidates for the management of oxidative stress, and may be useful in the treatment of chronic diseases.

  2. A review on alcohol: from the central action mechanism to chemical dependency

    Directory of Open Access Journals (Sweden)

    João Victor Vezali Costardi

    2015-08-01

    Full Text Available SummaryIntroduction:alcohol is a psychotropic depressant of the central nervous system (CNS that promotes simultaneous changes in several neuronal pathways, exerting a profound neurological impact that leads to various behavioral and biological alterations.Objectives:to describe the effects of alcohol on the CNS, identifying the signaling pathways that are modified and the biological effects resulting from its consumption.Methods:a literature review was conducted and articles published in different languages over the last 15 years were retrieved.Results:the studies reviewed describe the direct effect of alcohol on several neurotransmitter receptors (gamma-aminobutyric acid [GABA], glutamate, endocannabinoids AEA and 2-AG, among others, the indirect effect of alcohol on the limbic and opioid systems, and the effect on calcium and potassium channels and on proteins regulated by GABA in the hippocampus.Discussion and conclusion:the multiple actions of alcohol on the CNS result in a general effect of psychomotor depression, difficulties in information storage and logical reasoning and motor incoordination, in addition to stimulating the reward system, a fact that may explain the development of addiction. Knowledge on the neuronal signaling pathways that are altered by alcohol allows the identification of effectors which could reduce its central action, thus, offering new therapeutic perspectives for the rehabilitation of alcohol addicts.

  3. Taking action against ocean acidification: a review of management and policy options.

    Science.gov (United States)

    Billé, Raphaël; Kelly, Ryan; Biastoch, Arne; Harrould-Kolieb, Ellycia; Herr, Dorothée; Joos, Fortunat; Kroeker, Kristy; Laffoley, Dan; Oschlies, Andreas; Gattuso, Jean-Pierre

    2013-10-01

    Ocean acidification has emerged over the last two decades as one of the largest threats to marine organisms and ecosystems. However, most research efforts on ocean acidification have so far neglected management and related policy issues to focus instead on understanding its ecological and biogeochemical implications. This shortfall is addressed here with a systematic, international and critical review of management and policy options. In particular, we investigate the assumption that fighting acidification is mainly, but not only, about reducing CO2 emissions, and explore the leeway that this emerging problem may open in old environmental issues. We review nine types of management responses, initially grouped under four categories: preventing ocean acidification; strengthening ecosystem resilience; adapting human activities; and repairing damages. Connecting and comparing options leads to classifying them, in a qualitative way, according to their potential and feasibility. While reducing CO2 emissions is confirmed as the key action that must be taken against acidification, some of the other options appear to have the potential to buy time, e.g. by relieving the pressure of other stressors, and help marine life face unavoidable acidification. Although the existing legal basis to take action shows few gaps, policy challenges are significant: tackling them will mean succeeding in various areas of environmental management where we failed to a large extent so far.

  4. 76 FR 80847 - Enforcement Actions

    Science.gov (United States)

    2011-12-27

    ... into compliance before an enforcement action is taken by the Chair. Voluntary compliance is the goal of... existing compliance issues. The amendment retains the Chair's authority to issue an enforcement action at... compliance. In the Preliminary draft, the second action was called a ``non-compliance notice.''...

  5. Action observation and motor imagery for rehabilitation in Parkinson's disease: A systematic review and an integrative hypothesis.

    Science.gov (United States)

    Caligiore, Daniele; Mustile, Magda; Spalletta, Gianfranco; Baldassarre, Gianluca

    2017-01-01

    This article discusses recent evidence supporting the use of action observation therapy and motor imagery practice for rehabilitation of Parkinson's disease. A main question that emerges from the review regards the different effectiveness of these approaches and the possibility of integrating them into a single method to enhance motor behaviour in subjects with Parkinson's disease. In particular, the reviewed studies suggest that action observation therapy can have a positive effect on motor facilitation of patients and that a long-term rehabilitation program based on action observation therapy or motor imagery practice can bring some benefit on their motor recovery. Moreover, the paper discusses how the research on the combined use of action observation and motor imagery for motor improvements in healthy subjects may encourage the combined use of action observation therapy and motor imagery practice for therapeutic aims in Parkinson's disease. To date, this hypothesis has never been experimented.

  6. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review.

    Science.gov (United States)

    Ricketts, Marie-Louise; Moore, David D; Banz, William J; Mezei, Orsolya; Shay, Neil F

    2005-06-01

    Consumption of soy has been demonstrated to reduce circulating cholesterol levels, most notably reducing low-density lipoprotein (LDL) cholesterol levels in hypercholesterolemic individuals. The component or components that might be responsible for this effect is still a matter of debate or controversy among many researchers. Candidate agents include an activity of soy protein itself, bioactive peptides produced during the digestive process, or the soy isoflavones. Although soy intake may provide other health benefits including preventative or remediative effects on cancer, osteoporosis and symptoms of menopause, this review will focus on isoflavones as agents affecting lipid metabolism. Isoflavones were first discovered as a bioactive agent disrupting estrogen action in female sheep, thereby earning the often-used term 'phytoestrogens'. Subsequent work confirmed the ability of isoflavones to bind to estrogen receptors. Along with the cholesterol-lowering effect of soy intake, research that is more recent has pointed to a beneficial antidiabetic effect of soy intake, perhaps mediated by soy isoflavones. The two common categories of antidiabetic drugs acting on nuclear receptors known as peroxisome proliferator activated receptors (PPARs) are the fibrates and glitazones. We and others have recently asked the research question 'do the soy isoflavones have activities as either "phytofibrates" or "phytoglitazones"?' Such an activity should be able to be confirmed both in vivo and in vitro. In both the in vivo and in vitro cases, this action has indeed been confirmed. Further work suggests a possible action of isoflavones similar to the nonestrogenic ligands that bind the estrogen-related receptors (ERRs). Recently, these receptors have been demonstrated to contribute to lipolytic processes. Finally, evaluation of receptor activation studies suggests that thyroid receptor activation may provide additional clues explaining the metabolic action of isoflavones. The recent

  7. 77 FR 43086 - Solicitation of Written Comments on Draft Phase 3 Long-Term Care Facilities Strategy/Module for...

    Science.gov (United States)

    2012-07-23

    ... increasing healthcare personnel influenza vaccination coverage (Phases 1 & 2). DATES: Comments on the draft... the general public, providers, and other stakeholder groups. The Action Plan also delineates specific... Action Plan also addressed strategies to increase influenza vaccination coverage amongst...

  8. The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research

    Directory of Open Access Journals (Sweden)

    Hui Wang

    2014-01-01

    Full Text Available Rhizoma Coptidis (Huang Lian in Chinese pinyin is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions.

  9. A Comprehensive Review on Handcrafted and Learning-Based Action Representation Approaches for Human Activity Recognition

    Directory of Open Access Journals (Sweden)

    Allah Bux Sargano

    2017-01-01

    Full Text Available Human activity recognition (HAR is an important research area in the fields of human perception and computer vision due to its wide range of applications. These applications include: intelligent video surveillance, ambient assisted living, human computer interaction, human-robot interaction, entertainment, and intelligent driving. Recently, with the emergence and successful deployment of deep learning techniques for image classification, researchers have migrated from traditional handcrafting to deep learning techniques for HAR. However, handcrafted representation-based approaches are still widely used due to some bottlenecks such as computational complexity of deep learning techniques for activity recognition. However, approaches based on handcrafted representation are not able to handle complex scenarios due to their limitations and incapability; therefore, resorting to deep learning-based techniques is a natural option. This review paper presents a comprehensive survey of both handcrafted and learning-based action representations, offering comparison, analysis, and discussions on these approaches. In addition to this, the well-known public datasets available for experimentations and important applications of HAR are also presented to provide further insight into the field. This is the first review paper of its kind which presents all these aspects of HAR in a single review article with comprehensive coverage of each part. Finally, the paper is concluded with important discussions and research directions in the domain of HAR.

  10. Call to action: A new path for improving diabetes care for Indigenous peoples, a global review.

    Science.gov (United States)

    Harris, Stewart B; Tompkins, Jordan W; TeHiwi, Braden

    2017-01-01

    Diabetes has reached epidemic proportions in Indigenous populations around the globe, and there is an urgent need to improve the health and health equity of Indigenous peoples with diabetes through timely and appropriate diabetes prevention and management strategies. This review describes the evolution of the diabetes epidemic in Indigenous populations and associated risk factors, highlighting gestational diabetes and intergenerational risk, lifestyle risk factors and social determinants as having particular importance and impact on Indigenous peoples. This review further describes the impact of chronic disease and diabetes on Indigenous peoples and communities, specifically diabetes-related comorbidities and complications. This review provides continued evidence that dramatic changes are necessary to reduce diabetes-related inequities in Indigenous populations, with a call to action to support programmatic primary healthcare transformation capable of empowering Indigenous peoples and communities and improving chronic disease prevention and management. Promising strategies for transforming health services and care for Indigenous peoples include quality improvement initiatives, facilitating diabetes and chronic disease registry and surveillance systems to identify care gaps, and prioritizing evaluation to build the evidence-base necessary to guide future health policy and planning locally and on a global scale.

  11. 78 FR 68030 - Draft Guidance on Intellectual Property Rights for the National Network for Manufacturing...

    Science.gov (United States)

    2013-11-13

    ... National Network for Manufacturing Innovation and Draft Institute Performance Metrics for the National Network for Manufacturing Innovation AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice. SUMMARY: The Advanced Manufacturing National Program Office (AMNPO), hosted...

  12. 76 FR 24511 - Cabo Rojo National Wildlife Refuge, Cabo Rojo, Puerto Rico; Draft Comprehensive Conservation Plan...

    Science.gov (United States)

    2011-05-02

    ... Fish and Wildlife Service Cabo Rojo National Wildlife Refuge, Cabo Rojo, Puerto Rico; Draft Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION... Refuge System, consistent with sound principles of fish and wildlife management, conservation,...

  13. 78 FR 58340 - Cokeville Meadows National Wildlife Refuge, Lincoln County, WY; Draft Comprehensive Conservation...

    Science.gov (United States)

    2013-09-23

    ... Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION... Wildlife Service (Service), announce that our draft comprehensive conservation plan (CCP) and environmental... Refuge System, consistent with sound principles of fish and wildlife management, conservation,...

  14. 77 FR 61426 - Rose Atoll National Wildlife Refuge, American Samoa; Draft Comprehensive Conservation Plan and...

    Science.gov (United States)

    2012-10-09

    ... Fish and Wildlife Service Rose Atoll National Wildlife Refuge, American Samoa; Draft Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of..., consistent with sound principles of fish and wildlife management, conservation, legal mandates, and...

  15. 77 FR 32131 - Prime Hook National Wildlife Refuge, Sussex County, DE; Draft Comprehensive Conservation Plan and...

    Science.gov (United States)

    2012-05-31

    ... Fish and Wildlife Service Prime Hook National Wildlife Refuge, Sussex County, DE; Draft Comprehensive Conservation Plan and Environmental Impact Statement AGENCY: Fish and Wildlife Service, Interior. ACTION... System, consistent with sound principles of fish and wildlife management, conservation, legal...

  16. 77 FR 65574 - Lake Andes National Wildlife Refuge Complex, Lake Andes, SD; Draft Comprehensive Conservation...

    Science.gov (United States)

    2012-10-29

    ... Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION... Wildlife Service (Service), announce that our draft comprehensive conservation plan (CCP) and environmental... sound principles of fish and wildlife management, conservation, legal mandates, and our policies....

  17. 76 FR 45600 - Columbia National Wildlife Refuge, Adams and Grant Counties, WA; Draft Comprehensive Conservation...

    Science.gov (United States)

    2011-07-29

    ... Fish and Wildlife Service Columbia National Wildlife Refuge, Adams and Grant Counties, WA; Draft Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION... wildlife management, conservation, legal mandates, and our policies. In addition to outlining...

  18. 76 FR 24512 - Laguna Cartagena National Wildlife Refuge, Lajas, Puerto Rico; Draft Comprehensive Conservation...

    Science.gov (United States)

    2011-05-02

    ... Fish and Wildlife Service Laguna Cartagena National Wildlife Refuge, Lajas, Puerto Rico; Draft Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability; request for comments. SUMMARY: We, the Fish and Wildlife Service...

  19. 76 FR 5566 - Notice of Availability for the Draft Programmatic Environmental Assessment for the Development...

    Science.gov (United States)

    2011-02-01

    ... internet, are treated ] equally, become part of the public record on the Draft PEA, and will be considered... renewable energy. The purpose of the proposed action is to reduce dependency on fossil fuels and increase...

  20. 77 FR 76049 - Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Correction

    Science.gov (United States)

    2012-12-26

    ... guidance entitled ``Electronic Source Data in Clinical Investigations.'' The document was published with an... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Correction AGENCY: Food and Drug Administration, HHS. ACTION: Notice;...

  1. 76 FR 61366 - Food and Drug Administration Transparency Initiative: Draft Proposals for Public Comment to...

    Science.gov (United States)

    2011-10-04

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Transparency Initiative: Draft Proposals for Public Comment to Increase Transparency By Promoting Greater Access to the Agency's Compliance and Enforcement Data; Availability AGENCY: Food and Drug Administration, HHS. ] ACTION: Notice...

  2. 77 FR 2514 - National Ocean Council-National Ocean Policy Draft Implementation Plan

    Science.gov (United States)

    2012-01-18

    ... national economy, and are essential to public health and national security. The draft Implementation Plan... decision-making, and improved sharing of data and technology. For each action, the Implementation...

  3. TAS-102, a novel antitumor agent: a review of the mechanism of action.

    Science.gov (United States)

    Lenz, Heinz-Josef; Stintzing, Sebastian; Loupakis, Fotios

    2015-11-01

    Inhibition of nucleoside metabolism is an important principle in cancer therapy as evidenced by the role of fluoropyrimidines, such as 5-fluorouracil (5-FU), and antifolates in the treatment of many cancers. TAS-102 is an oral combination therapy consisting of trifluridine (FTD), a thymidine-based nucleoside analog, plus tipiracil hydrochloride (TPI), a novel thymidine phosphorylase inhibitor that improves the bioavailability of FTD. TAS-102 has demonstrated efficacy in 5-FU-refractory patients based on a different mechanism of action and has been approved for the treatment of metastatic colorectal cancer in Japan. This review describes the mechanism of action of TAS-102, highlighting key differences between TAS-102 and 5-FU-based therapies. While both FTD and 5-FU inhibit thymidylate synthase (TS), a central enzyme in DNA synthesis, sufficient TS inhibition by FTD requires continuous infusion; therefore, it is not considered a clinically relevant mechanism with oral dosing. Instead, the primary cytotoxic mechanism with twice-daily oral dosing, the schedule used in TAS-102 clinical development, is DNA incorporation. FTD incorporation into DNA induces DNA dysfunction, including DNA strand breaks. Uracil-based analogs such as 5-FU may also be incorporated into DNA; however, they are immediately cleaved off by uracil-DNA glycosylases, reducing their ability to damage DNA. Moreover, the TPI component may enhance the durability of response to FTD. With its distinct mechanism of action and metabolism, TAS-102 is a promising treatment option for patients resistant to or intolerant of 5-FU-based fluoropyrimidines. Copyright © 2015. Published by Elsevier Ltd.

  4. A review of the mechanism of action of lasers and photodynamic therapy for onychomycosis.

    Science.gov (United States)

    Bhatta, Anil Kumar; Keyal, Uma; Wang, Xiuli; Gellén, Emese

    2017-02-01

    Onychomycosis is one of the most common diseases in the field of dermatology. It refers to the fungal infection of the nail plate or nail bed with high incidence in the general population. The available treatment options for onychomycosis have limited use due to side effects, drug interactions, and contraindications, which necessitates the application of an alternative treatment for onychomycosis. In the recent years, lasers and photodynamic therapy (PDT) have been recognized as alternative treatment options. Most of the previous studies have found them to be safe and effective treatment modalities in this indication; however, the results varied greatly and the in vitro and in vivo outcomes are contradictory. In the present review, studies related to the mechanism of action of lasers and PDT for the treatment of onychomycosis will be discussed, with a focus on to find explanation to the contradictory results.

  5. [Pain assessment using the Facial Action Coding System. A systematic review].

    Science.gov (United States)

    Rojo, Rosa; Prados-Frutos, Juan Carlos; López-Valverde, Antonio

    2015-10-21

    Self-reporting is the most widely used pain measurement tool, although it may not be useful in patients with loss or deficit in communication skills. The aim of this paper was to undertake a systematic review of the literature of pain assessment through the Facial Action Coding System (FACS). The initial search found 4,335 references and, within the restriction «FACS», these were reduced to 40 (after exclusion of duplicates). Finally, only 26 articles meeting the inclusion criteria were included. Methodological quality was assessed using the GRADE system. Most patients were adults and elderly health conditions, or cognitive deficits and/or chronic pain. Our conclusion is that FACS is a reliable and objective tool in the detection and quantification of pain in all patients.

  6. The small molecular mass antifungal protein of Penicillium chrysogenum--a mechanism of action oriented review.

    Science.gov (United States)

    Hegedus, Nikoletta; Leiter, Eva; Kovács, Barbara; Tomori, Valéria; Kwon, Nak-Jung; Emri, Tamás; Marx, Florentine; Batta, Gyula; Csernoch, László; Haas, Hubertus; Yu, Jae-Hyuk; Pócsi, István

    2011-12-01

    The β-lactam producing filamentous fungus Penicillium chrysogenum secretes a 6.25 kDa small molecular mass antifungal protein, PAF, which has a highly stable, compact 3D structure and is effective against a wide spectrum of plant and zoo pathogenic fungi. Its precise physiological functions and mode of action need to be elucidated before considering possible biomedical, agricultural or food technological applications. According to some more recent experimental data, PAF plays an important role in the fine-tuning of conidiogenesis in Penicillium chrysogenum. PAF triggers apoptotic cell death in sensitive fungi, and cell death signaling may be transmitted through two-component systems, heterotrimeric G protein coupled signal transduction and regulatory networks as well as via alteration of the Ca(2+) -homeostasis of the cells. Possible biotechnological applications of PAF are also outlined in the review.

  7. The consequences of human actions on risks for infectious diseases: a review

    Science.gov (United States)

    Lindahl, Johanna F.; Grace, Delia

    2015-01-01

    The human population is growing, requiring more space for food production, and needing more animals to feed it. Emerging infectious diseases are increasing, causing losses in both human and animal lives, as well as large costs to society. Many factors are contributing to disease emergence, including climate change, globalization and urbanization, and most of these factors are to some extent caused by humans. Pathogens may be more or less prone to emergence in themselves, and rapidly mutating viruses are more common among the emerging pathogens. The climate-sensitive vector-borne diseases are likely to be emerging due to climate changes and environmental changes, such as increased irrigation. This review lists the factors within pathogens that make them prone to emergence, and the modes of transmission that are affected. The anthropogenic changes contributing to disease emergence are described, as well as how they directly and indirectly cause either increased numbers of susceptible or exposed individuals, or cause increased infectivity. Many actions may have multiple direct or indirect effects, and it may be difficult to assess what the consequences may be. In addition, most anthropogenic drivers are related to desired activities, such as logging, irrigation, trade, and travelling, which the society is requiring. It is important to research more about the indirect and direct effects of the different actions to understand both the benefits and the risks. PMID:26615822

  8. Viral inactivation in hemotherapy: systematic review on inactivators with action on nucleic acids

    Directory of Open Access Journals (Sweden)

    Patricia Marial Sobral

    2012-01-01

    Full Text Available The aim of this study was to conduct a systematic review on the photoinactivators used in hemotherapy, with action on viral genomes. The SciELO, Science Direct, PubMed and Lilacs databases were searched for articles. The inclusion criterion was that these should be articles on inactivators with action on genetic material that had been published between 2000 and 2010. The key words used in identifying such articles were "hemovigilance", "viral inactivation", "photodynamics", "chemoprevention" and "transfusion safety". Twenty-four articles on viral photoinactivation were found with the main photoinactivators covered being: methylene blue, amotosalen HCl, S-303 frangible anchor linker effector (FRALE, riboflavin and inactin. The results showed that methylene blue has currently been studied least, because it diminishes coagulation factors and fibrinogen. Riboflavin has been studied most because it is a photoinactivator of endogenous origin and has few collateral effects. Amotosalen HCl is effective for platelets and is also used on plasma, but may cause changes both to plasma and to platelets, although these are not significant for hemostasis. S-303 FRALE may lead to neoantigens in erythrocytes and is less indicated for red-cell treatment; in such cases, PEN 110 is recommended. Thus, none of the methods for pathogen reduction is effective for all classes of agents and for all blood components, but despite the high cost, these photoinactivators may diminish the risk of blood-transmitted diseases.

  9. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

    Directory of Open Access Journals (Sweden)

    Visweswara Rao Pasupuleti

    2017-01-01

    Full Text Available Background. There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. Scope and Approach. In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. Key Findings and Conclusions. An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions.

  10. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits.

    Science.gov (United States)

    Pasupuleti, Visweswara Rao; Sammugam, Lakhsmi; Ramesh, Nagesvari; Gan, Siew Hua

    2017-01-01

    There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions.

  11. The consequences of human actions on risks for infectious diseases: a review.

    Science.gov (United States)

    Lindahl, Johanna F; Grace, Delia

    2015-01-01

    The human population is growing, requiring more space for food production, and needing more animals to feed it. Emerging infectious diseases are increasing, causing losses in both human and animal lives, as well as large costs to society. Many factors are contributing to disease emergence, including climate change, globalization and urbanization, and most of these factors are to some extent caused by humans. Pathogens may be more or less prone to emergence in themselves, and rapidly mutating viruses are more common among the emerging pathogens. The climate-sensitive vector-borne diseases are likely to be emerging due to climate changes and environmental changes, such as increased irrigation. This review lists the factors within pathogens that make them prone to emergence, and the modes of transmission that are affected. The anthropogenic changes contributing to disease emergence are described, as well as how they directly and indirectly cause either increased numbers of susceptible or exposed individuals, or cause increased infectivity. Many actions may have multiple direct or indirect effects, and it may be difficult to assess what the consequences may be. In addition, most anthropogenic drivers are related to desired activities, such as logging, irrigation, trade, and travelling, which the society is requiring. It is important to research more about the indirect and direct effects of the different actions to understand both the benefits and the risks.

  12. Herbal Remedies for Coccidiosis Control: A Review of Plants, Compounds, and Anticoccidial Actions

    Science.gov (United States)

    Muthamilselvan, Thangarasu; Wu, Yueh-Chen

    2016-01-01

    Coccidiosis is the bane of the poultry industry causing considerable economic loss. Eimeria species are known as protozoan parasites to cause morbidity and death in poultry. In addition to anticoccidial chemicals and vaccines, natural products are emerging as an alternative and complementary way to control avian coccidiosis. In this review, we update recent advances in the use of anticoccidial phytoextracts and phytocompounds, which cover 32 plants and 40 phytocompounds, following a database search in PubMed, Web of Science, and Google Scholar. Four plant products commercially available for coccidiosis are included and discussed. We also highlight the chemical and biological properties of the plants and compounds as related to coccidiosis control. Emphasis is placed on the modes of action of the anticoccidial plants and compounds such as interference with the life cycle of Eimeria, regulation of host immunity to Eimeria, growth regulation of gut bacteria, and/or multiple mechanisms. Biological actions, mechanisms, and prophylactic/therapeutic potential of the compounds and extracts of plant origin in coccidiosis are summarized and discussed. PMID:27429634

  13. Herbal Remedies for Coccidiosis Control: A Review of Plants, Compounds, and Anticoccidial Actions

    Directory of Open Access Journals (Sweden)

    Thangarasu Muthamilselvan

    2016-01-01

    Full Text Available Coccidiosis is the bane of the poultry industry causing considerable economic loss. Eimeria species are known as protozoan parasites to cause morbidity and death in poultry. In addition to anticoccidial chemicals and vaccines, natural products are emerging as an alternative and complementary way to control avian coccidiosis. In this review, we update recent advances in the use of anticoccidial phytoextracts and phytocompounds, which cover 32 plants and 40 phytocompounds, following a database search in PubMed, Web of Science, and Google Scholar. Four plant products commercially available for coccidiosis are included and discussed. We also highlight the chemical and biological properties of the plants and compounds as related to coccidiosis control. Emphasis is placed on the modes of action of the anticoccidial plants and compounds such as interference with the life cycle of Eimeria, regulation of host immunity to Eimeria, growth regulation of gut bacteria, and/or multiple mechanisms. Biological actions, mechanisms, and prophylactic/therapeutic potential of the compounds and extracts of plant origin in coccidiosis are summarized and discussed.

  14. Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review

    Directory of Open Access Journals (Sweden)

    F. Bafort

    2014-01-01

    Full Text Available Lactoperoxidase is a member of the family of the mammalian heme peroxidases which have a broad spectrum of activity. Their best known effect is their antimicrobial activity that arouses much interest in in vivo and in vitro applications. In this context, the proper use of lactoperoxidase needs a good understanding of its mode of action, of the factors that favor or limit its activity, and of the features and properties of the active molecules. The first part of this review describes briefly the classification of mammalian peroxidases and their role in the human immune system and in host cell damage. The second part summarizes present knowledge on the mode of action of lactoperoxidase, with special focus on the characteristics to be taken into account for in vitro or in vivo antimicrobial use. The last part looks upon the characteristics of the active molecule produced by lactoperoxidase in the presence of thiocyanate and/or iodide with implication(s on its antimicrobial activity.

  15. Review of natural products actions on cytokines in inflammatory bowel disease.

    Science.gov (United States)

    Hur, Sun Jin; Kang, Sung Ho; Jung, Ho Sung; Kim, Sang Chul; Jeon, Hyun Soo; Kim, Ick Hee; Lee, Jae Dong

    2012-11-01

    The purpose of this review is to provide an overview of the effects that natural products have on inflammatory bowel disease (IBD) and to provide insight into the relationship between these natural products and cytokines modulation. More than 100 studies from the past 10 years were reviewed herein on the therapeutic approaches for treating IBD. The natural products having anti-IBD actions included phytochemicals, antioxidants, microorganisms, dietary fibers, and lipids. The literature revealed that many of these natural products exert anti-IBD activity by altering cytokine production. Specifically, phytochemicals such as polyphenols or flavonoids are the most abundant, naturally occurring anti-IBD substances. The anti-IBD effects of lipids were primarily related to the n-3 polyunsaturated fatty acids. The anti-IBD effects of phytochemicals were associated with modulating the levels of tumor necrosis factor α (TNF-α), interleukin (IL)-1, IL-6, inducible nitric oxide synthase, and myeloperoxide. The anti-IBD effects of dietary fiber were mainly mediated via peroxisome proliferator-activated receptor-γ, TNF-α, nitric oxide, and IL-2, whereas the anti-IBD effects of lactic acid bacteria were reported to influence interferon-γ, IL-6, IL-12, TNF-α, and nuclear factor-κ light-chain enhancer of activated B cells. These results suggest that the anti-IBD effects exhibited by natural products are mainly caused by their ability to modulate cytokine production. However, the exact mechanism of action of natural products for IBD therapy is still unclear. Thus, future research is needed to examine the effect of these natural products on IBD and to determine which factors are most strongly correlated with reducing IBD or controlling the symptoms of IBD.

  16. 77 FR 67635 - Fiscal Year 2013 Draft Work Plan

    Science.gov (United States)

    2012-11-13

    ... Year 2013 Draft Work Plan AGENCY: Denali Commission. ACTION: Notice. SUMMARY: The Denali Commission....C. 3121). The Act requires that the Commission develop proposed work plans for future spending and that the annual Work Plan be published in the Federal Register, providing an opportunity for a...

  17. 77 FR 29317 - Fiscal Year 2011 Draft Work Plan

    Science.gov (United States)

    2012-05-17

    ... Year 2011 Draft Work Plan AGENCY: Denali Commission. ACTION: Notice. SUMMARY: The Denali Commission....C. 3121). The Denali Commission Act requires that the Commission develop proposed work plans for future spending and that the annual Work Plan be published in the Federal Register, providing...

  18. 75 FR 22400 - Draft Test Guidelines; Reopening of Comment Period

    Science.gov (United States)

    2010-04-28

    ... AGENCY Draft Test Guidelines; Reopening of Comment Period AGENCY: Environmental Protection Agency (EPA). ACTION: Notice; reopening of comment period. SUMMARY: EPA issued a notice in the Federal Register of... antimicrobial agents. EPA received a request from the public to extend the comment period. After further...

  19. 77 FR 39446 - Draft Parachute Landing Area Standards

    Science.gov (United States)

    2012-07-03

    ... interested parties to review and comment on the draft ``Parachute Landing Area Standards'' contained in... comment consistent with 49 U.S.C. 47107(h), and (2) to invite interested parties to review and comment on... new PLA Standards set forth in Change 19 to AC 150/5300-13, ``Airport Design,'' which address...

  20. 75 FR 9228 - Draft Guidance for Industry on Non-Inferiority Clinical Trials; Availability

    Science.gov (United States)

    2010-03-01

    ...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled ``Non- Inferiority Clinical Trials.'' This draft guidance provides sponsors and review staff in the Center for Drug Evaluation and Research (CDER) and the Center for Biologics Evaluation and Research (CBER) with the agency's interpretation of the underlying principles involved in the......

  1. Re: “Comments on draft rules for granting Foreign Tax Credit”

    NARCIS (Netherlands)

    Sanghavi, Dhruv

    2016-01-01

    This letter to the Indian Ministry of Finance critically reviews the proposed rules for the grant of credit in India for taxes paid in a foreign country (Draft Rules). It points out what is perhaps the most egregious drawback in the Draft Rules - they do not consider the erosive impact foreign losse

  2. 76 FR 78661 - Correction for Draft Vieques Report: An Evaluation of Environmental, Biological, and Health Data...

    Science.gov (United States)

    2011-12-19

    ... Draft Vieques Report: An Evaluation of Environmental, Biological, and Health Data From the Island of....gov . SUPPLEMENTARY INFORMATION: This report's principal focus is to review updated environmental data... HUMAN SERVICES Agency for Toxic Substances and Disease Registry Correction for Draft Vieques Report:...

  3. 76 FR 64893 - Notice of Availability of Draft Environmental Impact Statement, Rosemont Copper Project on the...

    Science.gov (United States)

    2011-10-19

    ... Coronado National Forest announces the availability of a Draft Environmental Impact Statement (DEIS) for public review. The DEIS discloses the potential environmental impacts of the construction, operation and... Forest Service Notice of Availability of Draft Environmental Impact Statement, Rosemont Copper Project...

  4. Performance Reporting - The IASB's Proposed Formats of Financial Statements in the Exposure Draft of IAS1

    DEFF Research Database (Denmark)

    Thinggaard, Frank; Wagenhofer, Alfred; Evans, Lisa

    2006-01-01

    This paper is a response to the Exposure Draft of proposed amendments to IAS 1 Presentation of Financial Statements published by the IASB in March 2006. The objective is to bring to the standard setter’s attention research that is relevant to the issues raised in the exposure draft. We review...

  5. A Multidisciplinary Research Team Approach to Computer-Aided Drafting (CAD) System Selection. Final Report.

    Science.gov (United States)

    Franken, Ken; And Others

    A multidisciplinary research team was assembled to review existing computer-aided drafting (CAD) systems for the purpose of enabling staff in the Design Drafting Department at Linn Technical College (Missouri) to select the best system out of the many CAD systems in existence. During the initial stage of the evaluation project, researchers…

  6. Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review.

    Science.gov (United States)

    du Jardin, Kristian Gaarn; Müller, Heidi Kaastrup; Elfving, Betina; Dale, Elena; Wegener, Gregers; Sanchez, Connie

    2016-11-03

    A single i.v. infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor antagonist, may alleviate depressive symptoms within hours of administration in treatment resistant depressed patients, and the antidepressant effect may last for several weeks. These unique therapeutic properties have prompted researchers to explore the mechanisms mediating the antidepressant effects of ketamine, but despite many efforts, no consensus on its antidepressant mechanism of action has been reached. Recent preclinical reports have associated the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) with the antidepressant-like action of ketamine. Here, we review the current evidence for a serotonergic role in ketamine's antidepressant effects. The pharmacological profile of ketamine may include equipotent activity on several non-NMDA targets, and the current hypotheses for the mechanisms responsible for ketamine's antidepressant activity do not appear to preclude the possibility that non-glutamate neurotransmitters are involved in the antidepressant effects. At multiple levels, the serotonergic and glutamatergic systems interact, and such crosstalk could support the notion that changes in serotonergic neurotransmission may impact ketamine's antidepressant potential. In line with these prospects, ketamine may increase 5-HT levels in the prefrontal cortex of rats, plausibly via hippocampal NMDA receptor inhibition and activation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. In addition, a number of preclinical studies suggest that the antidepressant-like effects of ketamine may depend on endogenous activation of 5-HT receptors. Recent imaging and behavioral data predominantly support a role for 5-HT1A or 5-HT1B receptors, but the full range of 5-HT receptors has currently not been systematically investigated in this context. Furthermore, the nature of any 5-HT dependent mechanism in ketamine's antidepressant effect is currently not

  7. Treatment of acne with tea tree oil (melaleuca) products: a review of efficacy, tolerability and potential modes of action.

    Science.gov (United States)

    Hammer, K A

    2015-02-01

    Over-the-counter acne treatments containing tea tree oil from the plant Melaleuca alternifolia are widely available, and evidence indicates that they are a common choice amongst those self-treating their acne. The aims of this review were to collate and evaluate the clinical evidence on the use of tea tree oil products for treating acne, to review safety and tolerability and to discuss the underlying modes of therapeutic action.

  8. Review of Indigenous Health Curriculum in Nutrition and Dietetics at One Australian University: An Action Research Study

    Science.gov (United States)

    Wilson, Annabelle M.; Mehta, Kaye; Miller, Jacqueline; Yaxley, Alison; Thomas, Jolene; Jackson, Kathryn; Wray, Amanda; Miller, Michelle D.

    2015-01-01

    This article describes a review undertaken in 2012-2013 by Nutrition and Dietetics, Flinders University, to assess the Indigenous health curriculum of the Bachelor of Nutrition and Dietetics (BND) and Masters of Nutrition and Dietetics (MND). An action research framework was used to guide and inform inquiry. This involved four stages, each of…

  9. Insights into Attempts at Using Action Research in a Collaborative Work in a Policy Review Exercise in Botswana

    Science.gov (United States)

    Koosimile, Anthony Tsatsing

    2011-01-01

    In this paper I embrace the thinking that writing on one's experiences in the use of qualitative educational research strategies and principles could potentially contribute to furthering knowledge in the field. In adopting an action research framework to guide collaborative work in a policy review exercise in Botswana, I found that collaborative…

  10. 77 FR 66215 - Limitation of Claims Notice for Judicial Review of Actions by FHWA and Other Federal Agencies in...

    Science.gov (United States)

    2012-11-02

    ... proposed project to improve the Brent Spence Bridge over the Ohio River, as well as improvements to Interstate Routes 71 and 75 and interchanges in the City of Cincinnati, Hamilton County, State of Ohio and... project. DATES: A claim seeking judicial review of the Federal agency actions on the highway project will...

  11. Review of Indigenous Health Curriculum in Nutrition and Dietetics at One Australian University: An Action Research Study

    Science.gov (United States)

    Wilson, Annabelle M.; Mehta, Kaye; Miller, Jacqueline; Yaxley, Alison; Thomas, Jolene; Jackson, Kathryn; Wray, Amanda; Miller, Michelle D.

    2015-01-01

    This article describes a review undertaken in 2012-2013 by Nutrition and Dietetics, Flinders University, to assess the Indigenous health curriculum of the Bachelor of Nutrition and Dietetics (BND) and Masters of Nutrition and Dietetics (MND). An action research framework was used to guide and inform inquiry. This involved four stages, each of…

  12. Action Research, Assessment, and Institutional Review Boards (IRB): Conflicting Demands or Productive Tension for the Academic Librarian?

    Science.gov (United States)

    Farrell, Robert

    2014-01-01

    This article puts forward an "assessment/action research/publication" cycle that integrates aspects of the assessment, research, and Institutional Review Board (IRB) processes to provide academic librarians with a systematic approach for balancing competing workplace demands and give library managers a roadmap for creating a…

  13. Pipe drafting and design

    CERN Document Server

    Parisher, Roy A

    2011-01-01

    Pipe Drafting and Design, Third Edition provides step-by-step instructions to walk pipe designers, drafters, and students through the creation of piping arrangement and isometric drawings. It includes instructions for the proper drawing of symbols for fittings, flanges, valves, and mechanical equipment. More than 350 illustrations and photographs provide examples and visual instructions. A unique feature is the systematic arrangement of drawings that begins with the layout of the structural foundations of a facility and continues through to the development of a 3-D model. Advanced chapters

  14. Pipe drafting and design

    CERN Document Server

    Parisher, Roy A; Parisher

    2000-01-01

    Pipe designers and drafters provide thousands of piping drawings used in the layout of industrial and other facilities. The layouts must comply with safety codes, government standards, client specifications, budget, and start-up date. Pipe Drafting and Design, Second Edition provides step-by-step instructions to walk pipe designers and drafters and students in Engineering Design Graphics and Engineering Technology through the creation of piping arrangement and isometric drawings using symbols for fittings, flanges, valves, and mechanical equipment. The book is appropriate primarily for pipe

  15. Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review.

    Science.gov (United States)

    Katashima, Carlos K; Silva, Vagner R; Gomes, Tatyanne L; Pichard, Claude; Pimentel, Gustavo D

    2017-06-01

    This systematic review aimed at addressing the ursolic acid actions as an adjunctive treatment of the obesity-mediated metabolic abnormalities. To explore our aims, we used the literature search including clinical and animal studies using the Medline and Google Scholar (up to December 2015). Out of 63 screened studies, 17 presented eligibility criteria, such as the use of ursolic acid on adiposity, energy expenditure and skeletal muscle mass in mice and humans. In the literature, we found that several physiological and molecular mechanisms are implicated in the effects of ursolic acid on obesity, energy expenditure, hepatic steatosis, skeletal muscle mass loss and physical fitness, such as (1) increase of thermogenesis by modulation adipocyte transcription factors, activation of 5' adenosine monophosphate-activated protein kinase and overexpression of the uncoupling protein 1 thermogenic marker; (2) enhancement of skeletal muscle mass by activation in bloodstream growth hormone and insulin-like growth factor-1 concentrations secretion, as well as in the activation of mammalian target of rapamycin and inhibition of ring-finger protein-1; and (3) improvement of physical fitness by skeletal muscle proliferator-activated receptor gamma co-activator alpha and sirtuin 1 expression. Therefore, supplementation with ursolic acid may be an adjunctive therapy for prevention and treatment of obesity-mediated and muscle mass-mediated metabolic consequences. © 2017 World Obesity Federation.

  16. Categorizing health-related cues to action: using Yelp reviews of restaurants in Hawaii

    Science.gov (United States)

    Ariyasriwatana, W.; Buente, W.; Oshiro, M.; Streveler, D.

    2014-10-01

    Yelp, a social media site, undeniably has an influence on consumers' food choice in spite of its ability to reflect consumers' real voice being criticized. Since unhealthy food choices contribute to health problems, such as obesity and malnourishment, we attempted to examine these problems by better understanding consumers through health-related cues to action-a construct from the Health Belief Model (HBM)- on Yelp Honolulu's restaurant reviews. Our research revealed 13 main categories: Ingredient, Type of food, Taste, Lifestyle, Cooking, Option, Price, Portion, Well-being, Nutrition, Hygiene, Emotional attachment and indulgence, and Feeling. We argue that these categories may ultimately lead consumers to make healthier food choices. In search of the most appealing way to communicate with the target group, underlying concepts that derived from these categories can be tested. Marketers in food industry (or public health policy-makers) can craft their strategies for healthy food brands/products (or healthy eating scheme) based on the concept test research. Moreover, Yelp can apply these insights in the development of their algorithm and filter system in order to help consumers find healthy food if they wish to do so. Restaurants can also improve their strategy, menu, and communication execution to meet the growing demands of health conscious consumers.

  17. Regenerative endodontics: a review of current status and a call for action.

    Science.gov (United States)

    Murray, Peter E; Garcia-Godoy, Franklin; Hargreaves, Kenneth M

    2007-04-01

    Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. Researchers are working toward this objective. Regenerative endodontics is the creation and delivery of tissues to replace diseased, missing, and traumatized pulp. This review provides an overview of regenerative endodontics and its goals, and describes possible techniques that will allow regenerative endodontics to become a reality. These potential approaches include root-canal revascularization, postnatal (adult) stem cell therapy, pulp implant, scaffold implant, three-dimensional cell printing, injectable scaffolds, and gene therapy. These regenerative endodontic techniques will possibly involve some combination of disinfection or debridement of infected root canal systems with apical enlargement to permit revascularization and use of adult stem cells, scaffolds, and growth factors. Although the challenges of introducing endodontic tissue engineering therapies are substantial, the potential benefits to patients and the profession are equally ground breaking. Patient demand is staggering both in scope and cost, because tissue engineering therapy offers the possibility of restoring natural function instead of surgical placement of an artificial prosthesis. By providing an overview of the methodological issues required to develop potential regenerative endodontic therapies, we hope to present a call for action to develop these therapies for clinical use.

  18. Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

    Directory of Open Access Journals (Sweden)

    Marcio A. R. Araujo

    2012-02-01

    Full Text Available Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity of propolis of different origins and/or its isolated components, focusing on the mechanisms of action underlying this activity and also addressing some aspects of immunomodulatory effects. The search was performed of the following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate and ISI Web of Knowledgement. The anti-inflammatory activity was associated with propolis or compounds such as polyphenols (flavonoids, phenolic acids and their esters, terpenoids, steroids and amino acids. CAPE is the most studied compounds. The main mechanisms underlying the anti-inflammatory activity of propolis included the inhibition of cyclooxygenase and consequent inhibition of prostaglandin biosynthesis, free radical scavenging, inhibition of nitric oxide synthesis, reduction in the concentration of inflammatory cytokines and immunosuppressive activity. Propolis was found to exert an anti-inflammatory activity in vivo and in vitro models of acute and chronic inflammation and others studies, indicating its promising potential as anti-inflammatory agent of natural origin and as a source of chemical compounds for the development of new drugs.

  19. Evaluation of herbicides action on plant bioindicators by genetic biomarkers: a review.

    Science.gov (United States)

    de Souza, Cleiton Pereira; Guedes, Thays de Andrade; Fontanetti, Carmem Silvia

    2016-12-01

    The use of pesticides has increased worldwide, owing to the demand for products of good quality and to satisfy a growing population. Herbicides represent almost half of the total amount of pesticides used. Although important to the reduction of costs and an increase of productivity, their indiscriminate use, as well as that of the other pesticides, is a global environmental problem, since they affect the living organisms. To evaluate the damage caused by herbicides to the environment, different organisms have been used as bioindicators, especially higher plants, due to several advantages. This is a literature review on herbicidal actions in plant bioindicators, as assessed by genetic biomarkers. Also, the present manuscript aimed to characterize the main organisms (Allium cepa, Vicia faba and Tradescantia spp.) and the most used biomarkers (mitotic index, chromosome aberrations, micronuclei, sister chromatid exchange and mutations). We concluded that herbicides induce cytotoxicity and genotoxicity in the assessed bioindicators. The data corroborate the existing warnings of the risks that the indiscriminate and increasing use of pesticides poses to the environment and its biodiversity.

  20. PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting

    Science.gov (United States)

    Gąsiorowska, Emilia; Nowak-Markwitz, Ewa; Jankowska, Anna

    2017-01-01

    Poly(ADP-ribose) polymerases have shown true promise in early clinical studies due to reported activity in BRCA-associated cancers. PARP inhibitors may represent a potentially important new class of chemotherapeutic agents directed at targeting cancers with defective DNA-damage repair. In order to widen the prospective patient population that would benefit from PARP inhibitors, predictive biomarkers based on a clear understanding of the mechanism of action are required. In addition, a more sophisticated understanding of the toxicity profile is required if PARP inhibitors are to be employed in the curative, rather than the palliative, setting. PARP inhibitors have successfully moved into clinical practice in the past few years, with approval granted from the Food and Drug Administration (FDA) and European Medicines Agency (EMA) within the past two years. The United States FDA approval of olaparib applies to fourth-line treatment in germline BRCA-mutant ovarian cancer, and European EMA approval of olaparib for maintenance therapy in both germline and somatic BRCA-mutant platinum-sensitive ovarian cancer. This review covers the current understanding of PARP, its inhibition, and the basis of the excitement surrounding these new agents. It also evaluates future approaches and directions required to achieve full understanding of the intricate interplay of these agents at the cellular level. PMID:28250726

  1. 76 FR 47612 - NextEra Energy Seabrook, LLC; Notice of Availability of Draft Supplement 46 to the Generic...

    Science.gov (United States)

    2011-08-05

    ... COMMISSION NextEra Energy Seabrook, LLC; Notice of Availability of Draft Supplement 46 to the Generic...) has published a draft plant-specific supplement to the Generic Environmental Impact Statement for... renewal) include no action and reasonable alternative energy sources. Any interested party may...

  2. 75 FR 1806 - Draft General Management Plan and Environmental Impact Statement, New River Gorge National River, WV

    Science.gov (United States)

    2010-01-13

    ... National Park Service Draft General Management Plan and Environmental Impact Statement, New River Gorge... availability of the Draft General Management Plan and Environmental Impact Statement for New River Gorge.... Alternative 1 is the no action alternative, which would continue current management and trends, with no major...

  3. 78 FR 67187 - Notice of Availability of the Draft General Management Plan/Wilderness Study/Environmental Impact...

    Science.gov (United States)

    2013-11-08

    ... National Park Service Notice of Availability of the Draft General Management Plan/ Wilderness Study... availability of the Draft General Management Plan/Wilderness Study/Environmental Impact Statement (GMP/WS/EIS... for evaluating the action alternatives. The NPS would maintain the Big Spring Wilderness Study...

  4. 77 FR 33243 - Public Comment and Public Meeting on Draft Revisions to the Federal Environment Element of the...

    Science.gov (United States)

    2012-06-05

    ... COMMISSION Public Comment and Public Meeting on Draft Revisions to the Federal Environment Element of the..., intends to release for public comment draft revisions to the Federal Environment Element of the... Environment Element articulates policies that guide federal actions on mitigating environmental impacts...

  5. Replacement Nuclear Research Reactor. Supplement to Draft Environmental Impact Statement. Volume 3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    The Draft Environmental Impact Statement for a replacement research reactor at Lucas Heights, was available for public examination and comment for some three months during 1998. A Supplement to the Draft Environmental Impact Statement (Draft EIS) has been completed and was lodged with Environment Australia on 18 January 1999. The Supplement is an important step in the overall environmental assessment process. It reviews submissions received and provides the proponent`s response to issues raised in the public review period. General issues extracted from submissions and addressed in the Supplement include concern over liability issues, Chernobyl type accidents, the ozone layer and health issues. Further studies, relating to issues raised in the public submission process, were undertaken for the Supplementary EIS. These studies confirm, in ANSTO`s view, the findings of the Draft EIS and hence the findings of the Final EIS are unchanged from the Draft EIS

  6. Draft 1992 Resource Program : Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-01-01

    The 1992 Resource Program will propose actions to meet future loads placed on the Bonneville Power Administration (BPA). It will also discuss and attempt to resolve resource-related policy issues. The Resource Program assesses resource availability and costs, and analyzes resource requirements and alternative ways of meeting those requirements through both conservation and generation resources. These general resource conclusions are then translated to actions for both conservation and generation. The Resource Program recommends budgets for the Office of Energy Resources for Fiscal Years (FY) 1994 and 1995. BPA`s Resource Program bears directly on an important BPA responsibility: the obligation under the Northwest Power Act{sup 3} to meet the power requirements of public and private utility and direct service industrial (DSI) customers according to their contractual agreements. BPA`s Draft 1992 Resource Program is contained in four documents: (1) 1992 Resource Program Summary; (2) Technical Report; (3) Technical Assumptions Appendix; and, (4) Conservation Implementation Plan. This volume is the Draft 1992 Resource Program Technical Report, a comprehensive document that provides supporting data and analyses for Resource Program recommendations.

  7. Draft 1992 Resource Program : Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-01-01

    The 1992 Resource Program will propose actions to meet future loads placed on the Bonneville Power Administration (BPA). It will also discuss and attempt to resolve resource-related policy issues. The Resource Program assesses resource availability and costs, and analyzes resource requirements and alternative ways of meeting those requirements through both conservation and generation resources. These general resource conclusions are then translated to actions for both conservation and generation. The Resource Program recommends budgets for the Office of Energy Resources for Fiscal Years (FY) 1994 and 1995. BPA's Resource Program bears directly on an important BPA responsibility: the obligation under the Northwest Power Act{sup 3} to meet the power requirements of public and private utility and direct service industrial (DSI) customers according to their contractual agreements. BPA's Draft 1992 Resource Program is contained in four documents: (1) 1992 Resource Program Summary; (2) Technical Report; (3) Technical Assumptions Appendix; and, (4) Conservation Implementation Plan. This volume is the Draft 1992 Resource Program Technical Report, a comprehensive document that provides supporting data and analyses for Resource Program recommendations.

  8. An inexpensive underwater mine countermeasures simulator with real-time 3D after action review

    Directory of Open Access Journals (Sweden)

    Robert Stone

    2016-10-01

    Full Text Available This paper presents the results of a concept capability demonstration pilot study, the aim of which was to investigate how inexpensive gaming software and hardware technologies could be exploited in the development and evaluation of a simulator prototype for training Royal Navy mine clearance divers, specifically focusing on the detection and accurate reporting of the location and condition of underwater ordnance. The simulator was constructed using the Blender open source 3D modelling toolkit and game engine, and featured not only an interactive 3D editor for underwater scenario generation by instructors, but also a real-time, 3D After Action Review (AAR system for formative assessment and feedback. The simulated scenarios and AAR architecture were based on early human factors observations and briefings conducted at the UK's Defence Diving School (DDS, an organisation that provides basic military diving training for all Royal Navy and Army (Royal Engineers divers. An experimental pilot study was undertaken to determine whether or not basic navigational and mine detection components of diver performance could be improved as a result of exposing participants to the AAR system, delivered between simulated diving scenarios. The results suggest that the provision of AAR was accompanied by significant performance improvements in the positive identification of simulated underwater ordnance (in contrast to non-ordnance objects and on participants' description of their location, their immediate in-water or seabed context and their structural condition. Only marginal improvements were found with participants' navigational performance in terms of their deviation accuracies from a pre-programmed expert search path. Overall, this project contributes to the growing corpus of evidence supporting the development of simulators that demonstrate the value of exploiting open source gaming software and the significance of adopting established games design

  9. Peer Review Evaluation Process of Marie Curie Actions under EU's Seventh Framework Programme for Research.

    Directory of Open Access Journals (Sweden)

    David G Pina

    Full Text Available We analysed the peer review of grant proposals under Marie Curie Actions, a major EU research funding instrument, which involves two steps: an independent assessment (Individual Evaluation Report, IER performed remotely by 3 raters, and a consensus opinion reached during a meeting by the same raters (Consensus Report, CR. For 24,897 proposals evaluated from 2007 to 2013, the association between average IER and CR scores was very high across different panels, grant calls and years. Median average deviation (AD index, used as a measure of inter-rater agreement, was 5.4 points on a 0-100 scale (interquartile range 3.4-8.3, overall, demonstrating a good general agreement among raters. For proposals where one rater disagreed with the other two raters (n=1424; 5.7%, or where all 3 raters disagreed (n=2075; 8.3%, the average IER and CR scores were still highly associated. Disagreement was more frequent for proposals from Economics/Social Sciences and Humanities panels. Greater disagreement was observed for proposals with lower average IER scores. CR scores for proposals with initial disagreement were also significantly lower. Proposals with a large absolute difference between the average IER and CR scores (≥10 points; n=368, 1.5% generally had lower CR scores. An inter-correlation matrix of individual raters' scores of evaluation criteria of proposals indicated that these scores were, in general, a reflection of raters' overall scores. Our analysis demonstrated a good internal consistency and general high agreement among raters. Consensus meetings appear to be relevant for particular panels and subsets of proposals with large differences among raters' scores.

  10. The action of corticosteroids on orthodontic tooth movement: a literature review

    Directory of Open Access Journals (Sweden)

    Luegya Amorim Henriques Knop

    2012-12-01

    Full Text Available INTRODUCTION: Tooth movement is initially characterized by an acute sterile inflammation, followed by sequential multiple reactions in the periodontal ligament in response to biomechanical forces. Pharmacological agents such as corticosteroids may affect the course of orthodontic movement. Scientific studies show antagonistic actions of these drugs on bone resorption during tooth movement. OBJECTIVE: To review the literature about the effect of corticosteroids on orthodontic tooth movement. CONCLUSION: Patients should be questioned regarding the use of these drugs in the orthodontic practice and for those who use them, the orthodontic treatment should be differentiated, with longer intervals between visits and periodic X-rays due to the delay in bone formation observed in some scientific studies.INTRODUÇÃO: a movimentação dentária é caracterizada, inicialmente, por uma inflamação aguda estéril, seguida por reações múltiplas sequenciais no ligamento periodontal em resposta às forças biomecânicas. Agentes farmacológicos, como os corticosteroides, podem alterar o curso da movimentação ortodôntica. Os estudos científicos demonstram ações antagonistas dessas drogas sobre a reabsorção óssea durante a movimentação dentária. OBJETIVO: realizar revisão de literatura sobre a ação dos corticosteroides no movimento dentário ortodôntico. CONCLUSÃO: os pacientes devem ser questionados quanto ao uso dessas drogas na clínica ortodôntica e, para aqueles que fazem uso, o tratamento ortodôntico deve ser diferenciado, com intervalos maiores entre as consultas e solicitação periódica de radiografias devido ao atraso na neoformação óssea observado em alguns estudos científicos.

  11. Mechanisms of action of brief alcohol interventions remain largely unknown – A narrative review

    Directory of Open Access Journals (Sweden)

    Jacques eGaume

    2014-08-01

    Full Text Available A growing body of evidence has shown efficacy of brief intervention (BI for hazardous and harmful alcohol use in primary health care settings. Evidence for efficacy in other settings, and effectiveness when implemented at larger scale is disappointing. Indeed, BI comprises varying content, and exploring BI content and mechanisms of action may be a promising way to enhance efficacy and effectiveness.We searched Medline and PsychInfo, as well as references of retrieved publications for original research or reviews on active ingredients (or components, or mechanisms of face-to-face BIs (and its subtypes, including brief advice and brief motivational interviewing [BMI] for alcohol. Overall, BI active ingredients have been scarcely investigated, almost only within BMI, and mostly among Emergency Room patients, young adults, and US college students. This body of research has shown that personalized feedback may be an effective component; specific MI techniques showed mixed findings; decisional balance findings tended to suggest a potential detrimental effect; while change plan exercises, advice to reduce or stop drinking, presenting alternative change options, and moderation strategies are promising but need further study. Client change talk is a potential mediator of BMI effects; change in norm perceptions and enhanced discrepancy between current behavior and broader life goals and values have received preliminary support; readiness to change was only partially supported as a mediator; while enhanced awareness of drinking, perceived risks/benefits of alcohol use, alcohol treatment seeking, and self-efficacy were seldom studied and have as yet found no significant support as such.Research is obviously limited and has provided no clear and consistent evidence on the mechanisms of alcohol BI. How BI achieves the effects seen in randomized trials remains mostly unknown and should be investigated to inform the development of more effective interventions.

  12. Peer Review Evaluation Process of Marie Curie Actions under EU's Seventh Framework Programme for Research.

    Science.gov (United States)

    Pina, David G; Hren, Darko; Marušić, Ana

    2015-01-01

    We analysed the peer review of grant proposals under Marie Curie Actions, a major EU research funding instrument, which involves two steps: an independent assessment (Individual Evaluation Report, IER) performed remotely by 3 raters, and a consensus opinion reached during a meeting by the same raters (Consensus Report, CR). For 24,897 proposals evaluated from 2007 to 2013, the association between average IER and CR scores was very high across different panels, grant calls and years. Median average deviation (AD) index, used as a measure of inter-rater agreement, was 5.4 points on a 0-100 scale (interquartile range 3.4-8.3), overall, demonstrating a good general agreement among raters. For proposals where one rater disagreed with the other two raters (n=1424; 5.7%), or where all 3 raters disagreed (n=2075; 8.3%), the average IER and CR scores were still highly associated. Disagreement was more frequent for proposals from Economics/Social Sciences and Humanities panels. Greater disagreement was observed for proposals with lower average IER scores. CR scores for proposals with initial disagreement were also significantly lower. Proposals with a large absolute difference between the average IER and CR scores (≥10 points; n=368, 1.5%) generally had lower CR scores. An inter-correlation matrix of individual raters' scores of evaluation criteria of proposals indicated that these scores were, in general, a reflection of raters' overall scores. Our analysis demonstrated a good internal consistency and general high agreement among raters. Consensus meetings appear to be relevant for particular panels and subsets of proposals with large differences among raters' scores.

  13. The Innovation Paradox: A Selective Review of the Literature on Action Learning and Innovation

    Science.gov (United States)

    Pedler, Mike; Brook, Cheryl

    2017-01-01

    This paper explores selective literatures in the two fields of action learning and innovation, and seeks insights into the processes of, and connections between, innovation, engagement and implementation. We searched the action learning articles for references to innovation, beginning with the work of Revans, who highlights the innovation paradox,…

  14. Impact of Safety-Related Regulatory Action on Clinical Practice A Systematic Review

    NARCIS (Netherlands)

    Piening, Sigrid; Haaijer-Ruskamp, Flora M.; de Vries, Jonie T. N.; van der Elst, Menno E.; de Graeff, Pieter A.; Straus, Sabine M. J. M.; Mol, Peter G. M.

    2012-01-01

    Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of th

  15. Draft Test Guideline: Fish Acute Toxicity Test, Freshwater And Marine

    Science.gov (United States)

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  16. Draft Test Guideline: Generic Freshwater Microcosm Test, Laboratory

    Science.gov (United States)

    The following draft test guideline is part of a series of test guidelines that have been developed by EPA for use in the testing of pesticides and toxic substances, and the development of test data for submission to the Agency for review.

  17. Nanostructured materials for solid-state hydrogen storage: A review of the achievement of COST Action MP1103

    DEFF Research Database (Denmark)

    Callini, Elsa; Aguey-Zinsou, Kondo-Francois; Ahuja, Rajeev

    2016-01-01

    In the framework of the European Cooperation in Science and Technology (COST) Action MP1103 Nanostructured Materials for Solid-State Hydrogen Storage were synthesized, characterized and modeled. This Action dealt with the state of the art of energy storage and set up a competitive and coordinated...... the structure from bulk to thin film, nanoparticles and nanoconfined composites improved the hydrogen sorption properties and opened the perspective to new technological applications. Direct imaging of the hydrogenation reactions and in situ measurements under operando conditions have been carried out...... in these studies. Computational screening methods allowed the prediction of suitable compounds for hydrogen storage and the modeling of the hydrogen sorption reactions on mono-, bi-, and three-dimensional systems.This manuscript presents a review of the main achievements of this Action. © 2016 Hydrogen Energy...

  18. 76 FR 9027 - Draft Guidance for Industry and Food and Drug Administration Staff on Best Practices for...

    Science.gov (United States)

    2011-02-16

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff on Best Practices for Conducting and Reporting Pharmacoepidemiologic Safety Studies Using Electronic Healthcare Data Sets; Availability AGENCY: Food and Drug Administration, HHS. ACTION:...

  19. 78 FR 38994 - Implanted Blood Access Devices for Hemodialysis; Draft Guidance for Industry and Food and Drug...

    Science.gov (United States)

    2013-06-28

    ... HUMAN SERVICES Food and Drug Administration Implanted Blood Access Devices for Hemodialysis; Draft Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing...

  20. 78 FR 54899 - Draft Guidance for Industry on Specification of the Unique Facility Identifier System for Drug...

    Science.gov (United States)

    2013-09-06

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Specification of the Unique Facility Identifier System for Drug Establishment Registration; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing...

  1. Neurocognitive mechanisms of perception-action coordination: a review and theoretical integration.

    Science.gov (United States)

    Ridderinkhof, K Richard

    2014-10-01

    The present analysis aims at a theoretical integration of, and a systems-neuroscience perspective on, a variety of historical and contemporary views on perception-action coordination (PAC). We set out to determine the common principles or lawful linkages between sensory and motor systems that explain how perception is action-oriented and how action is perceptually guided. To this end, we analyze the key ingredients to such an integrated framework, examine the architecture of dual-system conjectures of PAC, and endeavor in an historical analysis of the key characteristics, mechanisms, and phenomena of PACs. This analysis will reveal that dual-systems views are in need of fundamental re-thinking, and its elements will be amalgamated with current views on action-oriented predictive processing into a novel integrative theoretical framework (IMPPACT: Impetus, Motivation, and Prediction in Perception-Action Coordination theory). From this framework and its neurocognitive architecture we derive a number of non-trivial predictions regarding conative, motive-driven PAC. We end by presenting a brief outlook on how IMPPACT might present novel insights into certain pathologies and into action expertise.

  2. Electromyography normalization methods for high-velocity muscle actions: review and recommendations.

    Science.gov (United States)

    Ball, Nick; Scurr, Joanna

    2013-10-01

    Electromyograms used to assess neuromuscular demand during high-velocity tasks require normalization to aid interpretation. This paper posits that, to date, methodological approaches to normalization have been ineffective and have limited the application of electromyography (EMG). There is minimal investigation seeking alternative normalization methods, which must be corrected to improve EMG application in sports. It is recognized that differing normalization methods will prevent cross-study comparisons. Users of EMG should aim to identify normalization methods that provide good reliability and a representative measure of muscle activation. The shortcomings of current normalization methods in high-velocity muscle actions assessment are evident. Advances in assessing alternate normalization methods have been done in cycling and sprinting. It is advised that when normalizing high-intensity muscle actions, isometric methods are used with caution and a dynamic alternative, where the muscle action is similar to that of the task is preferred. It is recognized that optimal normalization methods may be muscle and task dependent.

  3. A Conceptual Review on Action-Perception Coupling in the Musicians’ Brain: What Is It Good for?

    Directory of Open Access Journals (Sweden)

    Giacomo eNovembre

    2014-08-01

    Full Text Available Experience with a sensorimotor task, such as practicing a piano piece, leads to strong coupling of sensory (visual or auditory and motor cortices. Here we review behavioural and neurophysiological (M/EEG, TMS and fMRI research exploring this topic using the brain of musicians as a model system. Our review focuses on a recent body of evidence suggesting that this form of coupling might have (at least two cognitive functions. First, it leads to the generation of equivalent predictions (concerning both when and what event is more likely to occur during both perception and production of music. Second, it underpins the common coding of perception and action that supports the integration of the motor output of multiple musicians’ in the context of joint musical tasks. Essentially, training-based coupling of perception and action might scaffold the human ability to represent complex (structured actions and to entrain multiple agents – via reciprocal prediction and adaptation – in the pursuit of shared goals.

  4. Waste burner overfire draft system

    Energy Technology Data Exchange (ETDEWEB)

    Kahlert, G.; Pommer, L.; Davis, J.; Whebell, B.

    1977-11-22

    An overfire draft system for a waste burner is disclosed. Such system comprises air vents arranged circumferentially around the base of the burner for communicating the interior of the burner to the atmosphere and a draft modulated damper plate located in each air vent for automatically regulating the volume of overfire air delivered to the interior of the burner. Each draft modulated damper plate is provided with a lower lip which is deflected by a predetermined angle with respect to the plate to create an aerodynamic lift effect with large opening moment to assist the damper plate in its response under low air velocity conditions, and an oppositely deflected upper lip with proportionately less bent surface to avoid flutter or hunting of the damper as it approaches the maximum open position and to provide added dynamic opening force. The overfire draft system is also provided with ducts connected to the air vents and oriented so as to direct air tangentially around the base of the burner and toward the lower inside wall of the burner so as to minimize the disturbance of the inside air. The waste burner may also be provided with draft modulated or forced air vents arranged circumferentially at mid-elevation around the burner and duct means connected to such vents and directed at a small angle with the radius of the burner so as to cause turbulence in the flame zone and reduce the vertical velocity of gases above the fire, thus reducing emission of particulate materials.

  5. What predicts intention-behavior discordance? A review of the action control framework

    NARCIS (Netherlands)

    Rhodes, R.E.; de Bruijn, G.J.

    2013-01-01

    The physical activity intention-behavior gap is a focus of considerable research. The purpose of this article is to overview contemporary evidence for predictors of this intention-behavior discordance using the action control framework developed in our laboratories. We propose the hypothesis that

  6. A Critical Review of Mode of Action (MOA) Assignment Classifications for Ecotoxicology

    Science.gov (United States)

    There are various structure-based classification schemes to categorize chemicals based on mode of action (MOA) which have been applied for both eco and human health toxicology. With increasing calls to assess thousands of chemicals, some of which have little available informatio...

  7. Book Review ~ Action learning: Images and pathways. Author: Robert L. Dilworth and Verna J. Willis

    Directory of Open Access Journals (Sweden)

    Reviewed by Patrick J. Fahy

    2003-10-01

    Full Text Available Action learning, as defined in this book, is “a process of reflecting on one’s work and beliefs in the supportive/ confrontational environment of one’s peers for the purpose of gaining new insights and resolving real business and community problems in real time” (p. 11. The claims made for action learning are impressive. Action learning: * Allows participants (who work in groups called sets to answer the question, “What is an honest man, and what do I need to do to become one?” (p. viii. * Is more than learning by doing, action learning “has the potential for putting control of lifelong learning directly in the hands of learners, in ways that alter their perceptions, amplify self-efficacy, and re-connect these individuals to spontaneous curiosity and confidence in the exercise of their own good judgment” (p. xi. * Is a “sleeping giant in the catalogue of individual and organizational change strategies” (p. xi. * Is believed to address the five most important needs facing organizations today: 1 problem-solving; 2 organizational learning; 3 leadership development; 4 professional growth; and 5 career development (p. xiii.

  8. May spa therapy be a valid opportunity to treat hand osteoarthritis? A review of clinical trials and mechanisms of action

    Science.gov (United States)

    Fortunati, Nicola Angelo; Fioravanti, Antonella; Seri, Gina; Cinelli, Simone; Tenti, Sara

    2016-01-01

    Osteoarthritis (OA) is the most common form of arthritis and its current treatment includes non-pharmacological and pharmacological modalities. Spa therapy represents a popular treatment for many rheumatic diseases. The aim of this review was to summarize the currently available information on clinical effects and mechanisms of action of spa therapy in OA of the hand. We conducted a search of the literature to extract articles describing randomized clinical trials (RCTs) in hand OA published in the period 1952-2015. We identified three assessable articles reporting RCTs on spa therapy in hand OA. Data from these clinical trials support a beneficial effect of spa therapy on pain, function and quality of life in hand OA. Spa therapy seems to have a role in the treatment of hand OA. However, additional RCTs are necessary to clarify the mechanisms of action and the effects of the application of thermal treatments.

  9. May spa therapy be a valid opportunity to treat hand osteoarthritis? A review of clinical trials and mechanisms of action.

    Science.gov (United States)

    Fortunati, Nicola Angelo; Fioravanti, Antonella; Seri, Gina; Cinelli, Simone; Tenti, Sara

    2016-01-01

    Osteoarthritis (OA) is the most common form of arthritis and its current treatment includes non-pharmacological and pharmacological modalities. Spa therapy represents a popular treatment for many rheumatic diseases. The aim of this review was to summarize the currently available information on clinical effects and mechanisms of action of spa therapy in OA of the hand. We conducted a search of the literature to extract articles describing randomized clinical trials (RCTs) in hand OA published in the period 1952-2015. We identified three assessable articles reporting RCTs on spa therapy in hand OA. Data from these clinical trials support a beneficial effect of spa therapy on pain, function and quality of life in hand OA. Spa therapy seems to have a role in the treatment of hand OA. However, additional RCTs are necessary to clarify the mechanisms of action and the effects of the application of thermal treatments.

  10. 49 CFR 229.61 - Draft system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Draft system. 229.61 Section 229.61 Transportation... TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Draft System § 229.61 Draft system. (a) A.... Suspension System...

  11. Book Review: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice

    OpenAIRE

    Frederik Holst

    2013-01-01

    Book Review of the edited compilation: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice; Singapore: NUS Press, ISBN 978-697-5832-67-3, 412 pages

  12. Book Review: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice

    OpenAIRE

    Frederik Holst; Humboldt-Universität zu Berlin

    2014-01-01

    Book Review of the edited compilation: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice; Singapore: NUS Press, ISBN 978-697-5832-67-3, 412 pages

  13. Probiotics as beneficial microbes in aquaculture: an update on their multiple modes of action: a review

    DEFF Research Database (Denmark)

    Zorriehzahra, Mohammad Jalil; Delshad, Somayeh Torabi; Adel, Milad

    2016-01-01

    Wide and discriminate use of antibiotics has resulted in serious biological and ecological concerns, especially the emergence of antibiotic resistance. Probiotics, known as beneficial microbes, are being proposed as an effective and eco-friendly alternative to antibiotics. They were first applied...... in aquaculture species more than three decades ago, but considerable attention had been given only in the early 2000s. Probiotics are defined as live or dead, or even a component of the microorganisms that act under different modes of action in conferring beneficial effects to the host or to its environment....... Several probiotics have been characterized and applied in fish and a number of them are of host origin. Unlike some disease control alternatives being adapted and proposed in aquaculture where actions are unilateral, the immense potential of probiotics lies on their multiple mechanisms in conferring...

  14. Complementary Actions

    Directory of Open Access Journals (Sweden)

    Luisa eSartori

    2015-05-01

    Full Text Available Complementary colors are color pairs which, when combined in the right proportions, produce white or black. Complementary actions refer here to forms of social interaction wherein individuals adapt their joint actions according to a common aim. Notably, complementary actions are incongruent actions. But being incongruent is not sufficient to be complementary (i.e., to complete the action of another person. Successful complementary interactions are founded on the abilities: (i to simulate another person’s movements, (ii to predict another person’s future action/s, (iii to produce an appropriate incongruent response which differ, while interacting, with observed ones, and (iv to complete the social interaction by integrating the predicted effects of one’s own action with those of another person. This definition clearly alludes to the functional importance of complementary actions in the perception–action cycle and prompts us to scrutinize what is taking place behind the scenes. Preliminary data on this topic have been provided by recent cutting-edge studies utilizing different research methods. This mini-review aims to provide an up-to-date overview of the processes and the specific activations underlying complementary actions.

  15. Economic evidence on identifying clinically actionable findings with whole-genome sequencing: a scoping review.

    OpenAIRE

    2016-01-01

    The American College of Medical Genetics and Genomics (ACMG) recommends that mutations in 56 genes for 24 conditions are clinically actionable and should be reported as secondary findings after whole-genome sequencing (WGS). Our aim was to identify published economic evaluations of detecting mutations in these genes among the general population or among targeted/high-risk populations and conditions and identify gaps in knowledge. A targeted PubMed search from 1994 through November 2014 was pe...

  16. What predicts intention-behavior discordance? A review of the action control framework.

    Science.gov (United States)

    Rhodes, Ryan E; de Bruijn, Gert-Jan

    2013-10-01

    The physical activity intention-behavior gap is a focus of considerable research. The purpose of this article is to overview contemporary evidence for predictors of this intention-behavior discordance using the action control framework developed in our laboratories. We propose the hypothesis that intention-behavior discordance is from motivational (affective attitude, perceived behavioral control), self-regulatory (behavioral processes), and habitual (automaticity) constructs.

  17. Book Review: Making British law: committees in action by Louise Thompson

    OpenAIRE

    Berry, Richard

    2015-01-01

    In Making British Law: Committees in Action, Louise Thompson presents a history and statistical analysis of the work of bill committees – formerly known as standing committees – and their influence over the process of making British law. Thompson offers a well-evidenced argument that goes beyond the statistics to persuasively account for the role and importance of MPs in shaping government legislation through bill committees, writes Richard Berry.

  18. Mechanism of action of ulipristal acetate for emergency contraception: a systematic review

    Directory of Open Access Journals (Sweden)

    Elena eRosato

    2016-01-01

    Full Text Available SUMMARYUlipristal acetate (UPA is now recommended as first choice hormonal Emergency Contraception (EC, due to its higher efficacy and similar safety compared to Levonogestrel - EC. Even though all trials demonstrated that the first mechanism of action is inhibition of ovulation, some authors still postulate that a post fertilization effect is also possible, raising the alert on medication and fostering the ethical debate.A Medline database search was performed in order to find recent articles related to UPA’s effects on ovulation, on fallopian tube and on endometrium. We also analyzed the effects on sperm function and pregnancy. All studies conclude that UPA is effective in inhibition of ovulation even when administered shortly before LH peak. The effects on fallopian tube are unclear: according to some authors UPA inhibits ciliar beat through an agonistic effect on progesterone receptors, according to others it antagonizes the progesterone-induced ciliar beat decrease. Concerning the action on endometrium and on embryo implantation most of the studies concluded that low dose UPA used for EC has no significant effect on the decrease of endometrial thickness and on embryo’s attachment, but these results are still matter of debate. Finally recent evidence suggests that UPA modulates human sperm functions while it has no effect on established pregnancy. To date the majority of the evidence concur in excluding a post-fertilization effect of UPA, even though more studies are needed to clarify its mechanism of action.

  19. Probiotics as beneficial microbes in aquaculture: an update on their multiple modes of action: a review.

    Science.gov (United States)

    Zorriehzahra, Mohammad Jalil; Delshad, Somayeh Torabi; Adel, Milad; Tiwari, Ruchi; Karthik, K; Dhama, Kuldeep; Lazado, Carlo C

    2016-12-01

    Wide and discriminate use of antibiotics has resulted in serious biological and ecological concerns, especially the emergence of antibiotic resistance. Probiotics, known as beneficial microbes, are being proposed as an effective and eco-friendly alternative to antibiotics. They were first applied in aquaculture species more than three decades ago, but considerable attention had been given only in the early 2000s. Probiotics are defined as live or dead, or even a component of the microorganisms that act under different modes of action in conferring beneficial effects to the host or to its environment. Several probiotics have been characterized and applied in fish and a number of them are of host origin. Unlike some disease control alternatives being adapted and proposed in aquaculture where actions are unilateral, the immense potential of probiotics lies on their multiple mechanisms in conferring benefits to the host fish and the rearing environment. The staggering number of probiotics papers in aquaculture highlights the multitude of advantages from these microorganisms and conspicuously position them in the dynamic search for health-promoting alternatives for cultured fish. This paper provides an update on the use of probiotics in finfish aquaculture, particularly focusing on their modes of action. It explores the contemporary understanding of their spatial and nutritional competitiveness, inhibitory metabolites, environmental modification capability, immunomodulatory potential and stress-alleviating mechanism. This timely update affirms the importance of probiotics in fostering sustainable approaches in aquaculture and provides avenues in furthering its research and development.

  20. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Science.gov (United States)

    2010-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1) Send...

  1. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Science.gov (United States)

    2010-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director has...

  2. Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat-Systematic review.

    Science.gov (United States)

    Modena, Débora A Oliveira; da Silva, Caroline Nogueira; Grecco, Clovis; Guidi, Renata Michelini; Moreira, Renata Gomes; Coelho, Andresa A; Sant'Ana, Estela; de Souza, José Ricardo

    2017-10-01

    Extracorporeal Shockwave Therapy (ESWT) has had a wide use in rehabilitation, and has presented positive effects in the treatment of unaesthetic affections. The objective of the present study was to search, in the literature, the mechanisms of action and the physiological aspects of shockwaves acting on the biological tissue to improve the condition of cellulite and localized fat. The systematic review of the literature was carried out in the period of September 2016 to February 2017 based on the bibliographic databases such as Lilacs, Medline, PubMed, and SciELO. Fifteen articles were identified in that systematic review, three of which were excluded as they did not make the complete access to the article available or the theme investigated did not encompass the objective of the study. The revision demonstrated that extracorporeal shockwaves present relevant effects on the biological tissue, which leads to the restructuring of skin properties and subcutaneous tissue, thus clinically improving the aspects of cellulite and localized fat.

  3. A review of organotin regulatory strategies, pending actions, related costs and benefits.

    Science.gov (United States)

    Champ, M A

    2000-08-21

    Achieving consensus on equitable and effective national and global regulation(s) for the use of organotins as biocides in antifouling boat bottom paints has proven to be very complex and difficult for a variety of reasons as discussed in this paper. There appears to be broad agreement among stakeholders about the effectiveness of tributyltin (TBT) in antifouling paints. A draft Assembly Resolution prepared by the Marine Environmental Protection Committee (MEPC) of the International Maritime Organization (IMO) to propose a global ban on the use of organotins in antifouling paints was approved by the IMO at its 21st regular session (November 1999). In approving the Resolution, the Assembly agreed that a legally binding instrument (global convention--an international treaty) be developed by the Marine Environmental Protection Committee that should ensure by 1 January 2003, a ban on the application of tributyltin (TBT)-based antifouling paints; and 1 January 2008 as the last date for having TBT-based antifouling paint on a vessel. The Assembly also agreed that a diplomatic conference be held in 2001 to consider adoption of the international legal instrument. Monitoring, policing, enforcement, fines and record-keeping are yet to be defined. In addition, the MEPC has also proposed that IMO promotes the use of environmentally-safe anti-fouling technologies to replace TBT. Existing national regulations in the US and Europe have: (1) restricted the use of TBT in antifouling boat bottom paints by vessel size (less than 25 m in length), thus eliminating TBT from the smaller and recreational vessels that exist in shallow coastal waters where the impacted oysters species grow; (2) restricted the release rates of TBT from co-polymer paints; and (3) eliminated the use of free TBT in paints. The present movement toward a global ban suggests that the above regulatory approach has not been sufficient in some countries. Advocates of the ban cite international findings of: (1) higher

  4. 77 FR 62234 - Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, WY

    Science.gov (United States)

    2012-10-12

    ... Agency policy or views. Eastern Research Group, Inc., an EPA contractor for external peer review, will convene an independent panel of experts for peer review of this draft research report. Public comments submitted during the public comment period will be made available to the peer review panel for...

  5. 77 FR 19012 - Draft Research Report: Investigation of Ground Water Contamination Near Pavillion, WY

    Science.gov (United States)

    2012-03-29

    ... Agency policy or views. Eastern Research Group, Inc., an EPA contractor for external peer review, will convene an independent panel of experts for peer review of this draft research report. Public comments submitted during the public comment period will be made available to the peer review panel for...

  6. A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

    Directory of Open Access Journals (Sweden)

    Hao Sun

    2016-08-01

    Full Text Available AbstractRhein is a major medicinal ingredient isolated from several traditional Chinese medicines, including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and Polygonum multiflorum Thunb. Rhein has various pharmacological activities, such as anti-inflammatory, antitumor, antioxidant, antifibrosis, hepatoprotective, and nephroprotective activities. Although more than 100 articles in PubMed are involved in the pharmacological mechanism of action of rhein, only a few focus on the relationship of crosstalk among multiple pharmacological mechanisms. The mechanism of rhein involves multiple pathways which contain close interactions. From the overall perspective, the pathways which are related to the targets of rhein, are initiated by the membrane receptor. Then, MAPK and PI3K-AKT parallel signaling pathways are activated, and several downstream pathways are affected, thereby eventually regulating cell cycle and apoptosis. The therapeutic effect of rhein, as a multitarget molecule, is the synergistic and comprehensive result of the involvement of multiple pathways rather than the blocking or activation of a single signaling pathway. We review the pharmacological mechanisms of action of rhein by consulting literature published in the last 100 years in PubMed. We then summarize these pharmacological mechanisms from a comprehensive, interactive, and crosstalk perspective. In general, the molecular mechanism of action of drug must be understood from a systematic and holistic perspective, which can provide a theoretical basis for precise treatment and rational drug use.

  7. Gentiana scabra Bunge. Formula for Herpes Zoster: Biological Actions of Key Herbs and Systematic Review of Efficacy and Safety.

    Science.gov (United States)

    Wang, Kaiyi; Coyle, Meaghan E; Mansu, Suzi; Zhang, Anthony Lin; Xue, Charlie Changli

    2017-01-12

    This study reviewed the biological action of key herbs and evaluated systematically the efficacy and safety of oral Gentiana formula for herpes zoster (HZ). Experimental studies relevant to HZ were identified in PubMed. Randomized controlled trials using Gentiana formula for HZ were identified from nine English and Chinese databases. The primary outcome was evaluation of pain. Potential risk of bias was assessed. Meta-analysis was conducted using mean difference or risk ratio with 95% confidence intervals. Key herbs Gentiana scabra Bunge, Gentiana triflora Pall, Scutellaria baicalensis Georgi, and Gardenia jasminoides Ellis have shown antiinflammatory actions through inhibition of inflammatory cytokines and pro-inflammatory enzymes. Twenty-six clinical studies, involving 2955 participants, were included. Modified Gentiana formula resolved pain earlier than pharmacotherapy when used alone or combined with topical Chinese herbal medicine. Incidence of postherpetic neuralgia was lower (risk ratio 0.14, 95% confidence interval 0.03 to 0.74) with modified Gentiana formula plus topical Chinese herbal medicine. Mild adverse events were reported. Antiinflammatory actions of key herbs of Gentiana formula may explain clinical benefit in hastening pain relief and decreasing postherpetic neuralgia. Few adverse events were reported. Findings were limited by study quality and diversity in intervention and comparator dosage. Copyright © 2017 John Wiley & Sons, Ltd.

  8. Review article: potential mechanisms of action of rifaximin in the management of irritable bowel syndrome with diarrhoea.

    Science.gov (United States)

    Pimentel, M

    2016-01-01

    The role of gut microbiota in the pathophysiology of irritable bowel syndrome (IBS) is supported by various lines of evidence, including differences in mucosal and faecal microbiota between patients with IBS and healthy individuals, development of post-infectious IBS, and the efficacy of some probiotics and nonsystemic antibiotics (e.g. rifaximin). To review the literature regarding the role of rifaximin in IBS and its potential mechanism(s) of action. A literature search was conducted using the terms 'rifaximin', 'irritable bowel syndrome' and 'mechanism of action'. Rifaximin was approved in 2015 for the treatment of IBS with diarrhoea. In contrast to other currently available IBS therapies that require daily administration to maintain efficacy, 2-week rifaximin treatment achieved symptom improvement that persisted ≥12 weeks post-treatment. The mechanisms of action of rifaximin, therefore, may extend beyond direct bactericidal effects. Data suggest that rifaximin may decrease host proinflammatory responses to bacterial products in patients with IBS. In some cases, small intestinal bacterial overgrowth (SIBO) may play a role in the clinical symptoms of IBS. Because of the high level of solubility of rifaximin in the small intestine, rifaximin may reset microbial diversity in this environment. Consistent with this hypothesis, rifaximin has antibiotic efficacy against isolates derived from patients with SIBO. Resetting microbial diversity via rifaximin use may lead to a decrease in bacterial fermentation and a reduction in the clinical symptoms of IBS. © 2015 John Wiley & Sons Ltd.

  9. A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient.

    Science.gov (United States)

    Sun, Hao; Luo, Guangwen; Chen, Dahui; Xiang, Zheng

    2016-01-01

    Rhein is a major medicinal ingredient isolated from several traditional Chinese medicines, including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and Polygonum multiflorum Thunb. Rhein has various pharmacological activities, such as anti-inflammatory, antitumor, antioxidant, antifibrosis, hepatoprotective, and nephroprotective activities. Although more than 100 articles in PubMed are involved in the pharmacological mechanism of action of rhein, only a few focus on the relationship of crosstalk among multiple pharmacological mechanisms. The mechanism of rhein involves multiple pathways which contain close interactions. From the overall perspective, the pathways which are related to the targets of rhein, are initiated by the membrane receptor. Then, MAPK and PI3K-AKT parallel signaling pathways are activated, and several downstream pathways are affected, thereby eventually regulating cell cycle and apoptosis. The therapeutic effect of rhein, as a multitarget molecule, is the synergistic and comprehensive result of the involvement of multiple pathways rather than the blocking or activation of a single signaling pathway. We review the pharmacological mechanisms of action of rhein by consulting literature published in the last 100 years in PubMed. We then summarize these pharmacological mechanisms from a comprehensive, interactive, and crosstalk perspective. In general, the molecular mechanism of action of drug must be understood from a systematic and holistic perspective, which can provide a theoretical basis for precise treatment and rational drug use.

  10. The role of monoamines in the actions of established and "novel" antidepressant agents: a critical review.

    Science.gov (United States)

    Millan, Mark J

    2004-10-01

    Monoaminergic pathways are highly responsive to aversive stimuli and play a crucial role in the control of affect, cognition, endocrine secretion, chronobiotic rhythms, appetite, and motor function, all of which are profoundly disrupted in depressive states. Accordingly, a perturbation of monoaminergic transmission is implicated in the aetiology of depressive disorders, and all clinically available antidepressants increase corticolimbic availability of monoamines. However, their limited efficacy, delayed onset of action, and undesirable side effects underlie ongoing efforts to identify improved therapeutic agents. Sequencing the human genome has raised the hope not only of better symptomatic control of depression, but even of the prevention or cure of depressive states. In the pursuit of these goals, there is currently a tendency to focus on selective ligands of "novel" nonmonoaminergic targets. However, certain classes of novel agent (such as neurokinin(1) receptor antagonists) indirectly modulate the activity of monoaminergic networks. Others may act "downstream" of them, converging onto common cellular substrates controlling gene expression, synaptic plasticity, and neurogenesis. Further, by analogy to the broad-based actions of currently employed drugs, multitarget agents may be better adapted than selective agents to the management of depression-a complex disorder with hereditary, developmental, and environmental origins. It is, thus, important to continue the creative exploration of clinically validated and innovative monoaminergic strategies within a multitarget framework. In this light, drugs combining monoaminergic and nonmonoaminergic mechanisms of action may be of particular interest. The present article provides a critical overview of monoaminergic strategies for the treatment of depressive states, both established and under development, and discusses interactions of novel "nonmonoaminergic" antidepressants with monoaminergic mechanisms.

  11. Corporate action on climate change: an independent review focusing on Canada's electric and natural gas utilities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This independent report on corporate action on climate change is the fourth in a series of studies undertaken by the Pembina Institute, a citizen-based organization involved in environmental education, research, policy development and consulting. The objective of the report is to identify the key elements that are required to produce a credible and effective corporate action plan to reduce greenhouse gas (GHG) emissions; to create a standardized mechanism to assess the credibility and effectiveness of corporate action plans to reduce GHG emissions; and to provide Canadians with as comparative assessment of the climate change performance of individual companies, by providing the means to identify the leaders and laggards within different industry sectors. The report focuses on the quality of actions being taken to reduce GHG emissions specifically by the electric and natural gas utility companies. Future reviews will concentrate on the climate protection performers of companies in other sectors of industry. Criteria for inclusion in this report require that the company must be a participant in Canada's Climate Change Voluntary Challenge and Registry (VCR) Program; must have submitted a corporate climate change report to the VCR between Sept. 1998 and March 31, 1999, including the GHG inventory that presents recent emissions data, identifies at least one activity that has been taken to reduce GHG emissions, and quantifying the benefits of that activity in tonnes of CO{sub 2} equivalent emissions per year. While Ontario alone has over 300 companies that fit into the electricity and natural gas utility sector, only 16 companies across the country have met all the criteria. These companies (listed in Section 2.1) must be recognized as the leaders in the country in addressing the climate change issue. Other companies that report to VCR but did not meet all the criteria and the reason for their exclusion are listed in Appendix D. The report describes the methodology

  12. Buspirone: review of its pharmacology and current perspectives on its mechanism of action.

    Science.gov (United States)

    Eison, A S; Temple, D L

    1986-03-31

    Buspirone is a novel anxiolytic agent unrelated to the benzodiazepines in structure or pharmacologic properties. Extensive clinical studies have shown buspirone to be effective in the treatment of anxiety, with efficacy comparable to diazepam or clorazepate. Buspirone exhibits a unique pharmacologic profile in that it alleviates anxiety without causing sedation or functional impairment and does not promote abuse or physical dependence. Furthermore, preclinical studies have shown that buspirone does not possess anticonvulsant or muscle relaxant properties and does not interact significantly with central nervous system depressants. Biochemical and electrophysiologic studies indicate that buspirone alters monoaminergic and GABAergic systems in a manner different from that of the benzodiazepines. The uniform depressant action of the benzodiazepines upon serotonergic, noradrenergic, and dopaminergic cell firing may result from their facilitatory effect on gamma-aminobutyric acid and its known inhibitory influence in these monoaminergic areas. Unlike the benzodiazepines, buspirone exerts a differential influence upon monoaminergic neuronal activity, suppressing serotonergic activity while enhancing dopaminergic and noradrenergic cell firing. The mechanism of action of buspirone challenges the notion that only one neurotransmitter mediates anxiety. The interaction with multiple neurotransmitters at multiple brain sites suggests that buspirone may alter diverse activities within a "neural matrix of anxiety." In contrast to the benzodiazepines, buspirone orchestrates activity within this neural matrix to achieve effective treatment of anxiety while preserving arousal and attentional processes.

  13. AGILE DRAFTING OF OUTSOURCING CONTRACTS

    DEFF Research Database (Denmark)

    Schlichter, Bjarne Rerup; Storgaard, Kristian

    2015-01-01

    and in several parallel tracks using different competencies. By the use of an illustrative case-study, this paper explores how scrum can be applied to enhance the process of drafting outsourcing contracts. The analysis indicates that the use of an agile method, such as Scrum, can be beneficial in this context...

  14. Health Literacy and Health Actions: A Review and a Framework from Health Psychology

    Science.gov (United States)

    von Wagner, Christian; Steptoe, Andrew; Wolf, Michael S.; Wardle, Jane

    2009-01-01

    The association between performance on health literacy measures and health outcomes is well established. The next step is to understand the processes through which health literacy affects health. This review introduces a framework drawing on ideas from health psychology and proposing that associations between health literacy and health outcomes…

  15. Review of ultrasonic irrigation in endodontics: increasing action of irrigating solutions

    Science.gov (United States)

    Mozo, Sandra; Llena, Carmen

    2012-01-01

    Introduction: Effective irrigant delivery and agitation are prerequisites for successful endodontic treatment. Ultrasonic irrigation can be performed with or without simultaneous ultrasonic instrumentation. Existing literature reveals that ultrasonic irrigation may have a very positive effect on chemical, biological and physical debridement of the root canal system as investigated in many in vitro studies. Objective: The purpose of this review article was to summarize and discuss the available information concerning ultrasonic irrigation in endodontics. Methods: This article presents an overview of ultrasonic irrigation methods and their debridement efficacy. In this paper the relevant literature on passive ultrasonic irrigation is reviewed. Information from original scientific papers or reviews listed in MEDLINE and Cochrane were included in the review. Results: The use of ultrasound in the irrigation procedure results in improved canal cleanliness, better irrigant transfer to the canal system, soft tissue debridement, and removal of smear layer and bacteria. There are many in vitro studies, but there is a need to standardize protocols, and correlate the clinical efficacy of ultrasonic devices with improved treatment outcomes. Understanding the basis of ultrasonic irrigation is fundamental for clinicians and researchers to improve the design and use of ultrasonic irrigation. Key words:Ultrasonic irrigation, ultrasound, smear layer, endodontics. PMID:22143738

  16. Stylizing Genderlect Online for Social Action: A Corpus Analysis of "BIC Cristal for Her" Reviews

    Science.gov (United States)

    Ray, Brian

    2016-01-01

    This article introduces the concept of stylization and illustrates its usefulness for studying online discourse by examining how writers have employed it in order to parody sexist products such as BIC Cristal for Her, using genderlect in order to introduce dissonance into and reframe patriarchal discourse. A corpus analysis of 671 reviews, written…

  17. Review of ultrasonic irrigation in endodontics: increasing action of irrigating solutions.

    Science.gov (United States)

    Mozo, Sandra; Llena, Carmen; Forner, Leopoldo

    2012-05-01

    Effective irrigant delivery and agitation are prerequisites for successful endodontic treatment. Ultrasonic irrigation can be performed with or without simultaneous ultrasonic instrumentation. Existing literature reveals that ultrasonic irrigation may have a very positive effect on chemical, biological and physical debridement of the root canal system as investigated in many in vitro studies. The purpose of this review article was to summarize and discuss the available information concerning ultrasonic irrigation in endodontics. This article presents an overview of ultrasonic irrigation methods and their debridement efficacy. In this paper the relevant literature on passive ultrasonic irrigation is reviewed. Information from original scientific papers or reviews listed in MEDLINE and Cochrane were included in the review. The use of ultrasound in the irrigation procedure results in improved canal cleanliness, better irrigant transfer to the canal system, soft tissue debridement, and removal of smear layers and bacteria. There are many in vitro studies, but there is a need to standardize protocols, and correlate the clinical efficacy of ultrasonic devices with improved treatment outcomes. Understanding the basis of ultrasonic irrigation is fundamental for clinicians and researchers to improve the design and use of ultrasonic irrigation.

  18. Update to An Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the United States for the Years 1987, 1995, and 2000 (2013, External Review Draft)

    Science.gov (United States)

    In 2006, EPA published an inventory of sources and environmental releases of dioxin-like compounds in the United States. This draft report presents an update and revision to that dioxin source inventory. It also presents updated estimates of environmental releases of dioxin-like...

  19. Data Warehouse Governance Programs in Healthcare Settings: A Literature Review and a Call to Action

    OpenAIRE

    Elliott, Thomas E; Holmes, John H; Davidson,Arthur J.; La Chance, Pierre-Andre; Nelson, Andrew F.; Steiner, John F.

    2013-01-01

    Purpose: Given the extensive data stored in healthcare data warehouses, data warehouse governance policies are needed to ensure data integrity and privacy. This review examines the current state of the data warehouse governance literature as it applies to healthcare data warehouses, identifies knowledge gaps, provides recommendations, and suggests approaches for further research. Methods: A comprehensive literature search using five data bases, journal article title-search, and citation searc...

  20. Data warehouse governance programs in healthcare settings: a literature review and a call to action.

    Science.gov (United States)

    Elliott, Thomas E; Holmes, John H; Davidson, Arthur J; La Chance, Pierre-Andre; Nelson, Andrew F; Steiner, John F

    2013-01-01

    Given the extensive data stored in healthcare data warehouses, data warehouse governance policies are needed to ensure data integrity and privacy. This review examines the current state of the data warehouse governance literature as it applies to healthcare data warehouses, identifies knowledge gaps, provides recommendations, and suggests approaches for further research. A comprehensive literature search using five data bases, journal article title-search, and citation searches was conducted between 1997 and 2012. Data warehouse governance documents from two healthcare systems in the USA were also reviewed. A modified version of nine components from the Data Governance Institute Framework for data warehouse governance guided the qualitative analysis. Fifteen articles were retrieved. Only three were related to healthcare settings, each of which addressed only one of the nine framework components. Of the remaining 12 articles, 10 addressed between one and seven framework components and the remainder addressed none. Each of the two data warehouse governance plans obtained from healthcare systems in the USA addressed a subset of the framework components, and between them they covered all nine. While published data warehouse governance policies are rare, the 15 articles and two healthcare organizational documents reviewed in this study may provide guidance to creating such policies. Additional research is needed in this area to ensure that data warehouse governance polices are feasible and effective. The gap between the development of data warehouses in healthcare settings and formal governance policies is substantial, as evidenced by the sparse literature in this domain.

  1. NRC Consultation and Monitoring at the Savannah River Site: Focusing Reviews of Two Different Disposal Actions - 12181

    Energy Technology Data Exchange (ETDEWEB)

    Ridge, A. Christianne; Barr, Cynthia S.; Pinkston, Karen E.; Parks, Leah S.; Grossman, Christopher J.; Alexander, George W. [U.S. Nuclear Regulatory Commission (United States)

    2012-07-01

    Section 3116 of the Ronald W. Reagan National Defense Authorization Act for Fiscal Year 2005 (NDAA) requires the U.S. Department of Energy (DOE) to consult with the U.S. Nuclear Regulatory Commission (NRC) for certain non-high level waste determinations. The NDAA also requires NRC to monitor DOE's disposal actions related to those determinations. In Fiscal Year 2011, the NRC staff reviewed DOE performance assessments for tank closure at the F-Tank Farm (FTF) Facility and salt waste disposal at the Saltstone Disposal Facility (SDF) at the Savannah River Site (SRS) as part of consultation and monitoring, respectively. Differences in inventories, waste forms, and key barriers led to different areas of focus in the NRC reviews of these two activities at the SRS. Because of the key role of chemically reducing grouts in both applications, the evaluation of chemical barriers was significant to both reviews. However, radionuclide solubility in precipitated metal oxides is expected to play a significant role in FTF performance whereas release of several key radionuclides from the SDF is controlled by sorption or precipitation within the cementitious wasteform itself. Similarly, both reviews included an evaluation of physical barriers to flow, but differences in the physical configurations of the waste led to differences in the reviews. For example, NRC's review of the FTF focused on the modeled degradation of carbon steel tank liners while the staff's review of the SDF performance included a detailed evaluation of the physical degradation of the saltstone wasteform and infiltration-limiting closure cap. Because of the long time periods considered (i.e., tens of thousands of years), the NRC reviews of both facilities included detailed evaluation of the engineered chemical and physical barriers. The NRC staff reviews of residual waste disposal in the FTF and salt waste disposal in the SDF focused on physical barriers to flow and chemical barriers to

  2. A Critical Review on the National Energy Efficiency Action Plan of Egypt.

    Directory of Open Access Journals (Sweden)

    Hatem Elrefaei

    2014-03-01

    Full Text Available Egypt, as with other developing countries, faces a major energy security problem, which strongly impacts all national plans for economic development. A sound energy strategy is crucially needed, and should be based on two pillars: first, boosting the production of clean energy from various renewable and non-renewable sources, and second, managing and rationalizing energy demand, with related reforms. Some steps were taken by previous Egyptian governments regarding these two pillars. In February 2008, the Ministry of Electricity and Energy of Egypt put a target of 20% of electricity to come from renewable energy resources by 2020. In July 2012, the Ministerial Cabinet approved both the Egyptian Solar Plan targeting 3500 MW of solar energy by 2027, and the National Energy Efficiency Action Plan (NEEAP to reduce energy consumption 5% during the period from 2012-2015 compared to the average consumption of the previous 5 years. We believe that these plans will not bring their expected fruits unless they are well orchestrated with other sectoral development plans in areas such as agriculture, transport, housing and services, amongst others. This paper aims to investigate the Egyptian NEEAP and assess whether the adopted national energy efficiency plan and the associated policies on all other development sectors adopted by the government have sound implications. We aim to find out whether the development policies with a focus on energy policy are set in an integrated or fragmented way.

  3. Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus.

    Science.gov (United States)

    Leinninger, Gina M

    2011-09-26

    The lateral hypothalamic area (LHA) was initially described as a "feeding center" but we are now beginning to understand that the LHA contributes to other aspects of physiology as well. Indeed, the best-characterized neuronal populations of the LHA (which contain melanin-concentrating hormone (MCH) or the hypocretins/orexins (OX)) are not strictly orexigenic, but also have roles in regulation of the autonomic and sympathetic nervous systems as well as in modulating motivated behavior. Leptin is an anorectic hormone that regulates energy homeostasis and the mesolimbic DA system (which transduces the wanting of food, drugs of abuse, and sex) in part, via actions at the LHA. At least three populations of LHA neurons are regulated by leptin: those containing MCH, OX or the long form of the leptin receptor, LepRb. The emerging picture of leptin interaction with these LHA populations suggests that the LHA is not merely regulating feeding, but is a crucial integrator of energy balance and motivated behavior.

  4. Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: a critical review.

    Science.gov (United States)

    Vachon, Vincent; Laprade, Raynald; Schwartz, Jean-Louis

    2012-09-15

    Bacillus thuringiensis (Bt) Cry toxins constitute the active ingredient in the most widely used biological insecticides and insect-resistant transgenic crops. A clear understanding of their mode of action is necessary for improving these products and ensuring their continued use. Accordingly, a long history of intensive research has established that their toxic effect is due primarily to their ability to form pores in the plasma membrane of the midgut epithelial cells of susceptible insects. In recent years, a rather elaborate model involving the sequential binding of the toxins to different membrane receptors has been developed to describe the events leading to membrane insertion and pore formation. However, it was also proposed recently that, in contradiction with this mechanism, Bt toxins function by activating certain intracellular signaling pathways which lead to the necrotic death of their target cells without the need for pore formation. Because work in this field has largely focused, for several years, on the elaboration and promotion of these two models, the present revue examines in detail the experimental evidence on which they are based. It is concluded that the presently available information still supports the notion that Bt Cry toxins act by forming pores, but most events leading to their formation, following binding of the activated toxins to their receptors, remain relatively poorly understood.

  5. Ginger-Mechanism of action in chemotherapy-induced nausea and vomiting: A review.

    Science.gov (United States)

    Marx, Wolfgang; Ried, Karin; McCarthy, Alexandra L; Vitetta, Luis; Sali, Avni; McKavanagh, Daniel; Isenring, Liz

    2017-01-02

    Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT3, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.

  6. 77 FR 74669 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2012-12-17

    ... Product-Specific Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS... additional draft and revised draft product-specific bioequivalence (BE) recommendations. The recommendations... industry entitled ``Bioequivalence Recommendations for Specific Products,'' which explained the...

  7. 78 FR 37230 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2013-06-20

    ... Product-Specific Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS... additional draft and revised draft product-specific bioequivalence (BE) recommendations. The recommendations... industry entitled ``Bioequivalence Recommendations for Specific Products,'' which explained the...

  8. 78 FR 66745 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2013-11-06

    ... Product-Specific Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS... additional draft and revised draft product-specific bioequivalence (BE) recommendations. The recommendations... industry entitled ``Bioequivalence Recommendations for Specific Products,'' which explained the...

  9. 77 FR 10536 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2012-02-22

    ... Product-Specific Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS... additional draft and revised draft product-specific bioequivalence (BE) recommendations. The recommendations... guidance for industry entitled ``Bioequivalence Recommendations for Specific Products,'' which...

  10. 78 FR 20925 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2013-04-08

    ... Product-Specific Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS... additional draft and revised draft product-specific bioequivalence (BE) recommendations. The recommendations... guidance for industry entitled ``Bioequivalence Recommendations for Specific Products,'' which...

  11. 77 FR 35688 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2012-06-14

    ... Product-Specific Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration, HHS... additional draft and revised draft product-specific bioequivalence (BE) recommendations. The recommendations... guidance for industry entitled ``Bioequivalence Recommendations for Specific Products,'' which...

  12. Parents’ actions, challenges, and needs while enabling participation of children with a physical disability: a scoping review

    Directory of Open Access Journals (Sweden)

    Piškur Barbara

    2012-11-01

    Full Text Available Abstract Background Pediatric rehabilitation considers Family-centered service (FCS as a way to increase participation of children with a physical disability in daily life. An important principal is that parents greatly contribute to their child’s participation at school, at home, and in the community. However, it is unclear what kind of information is available from literature about what parents actually do to support their child’s participation and what problems and needs they experience? Hence, the aim of this study was to provide an overview of the actions, challenges, and needs of parents in enabling participation of their child with a physical disability that is neurological and non-progressive in nature. Methods Scoping review with extensive literature search (September 2011 and a thematic analysis to synthesize findings. Results Fourteen relevant articles revealed two major themes: ‘parents enable and support performance of meaningful activities’ and ‘parents enable, change and use the environment’. Each theme holds a number of actions (e.g. choosing the right type of meaningful activities for facilitating social contacts and challenges (e.g. negative attitudes of other people. Less information is available about the needs of parents. Conclusions This study indicates that parents apply a broad range of strategies to support participation of their children. They experience many challenges, especially as a result of constraints in the social and physical environments. However, this review also shows that little is known about needs of parents in facilitating participation. As Family-centered service (FCS philosophy is all about the needs of the child and the family, it is essential to further investigate the needs of the parents and to understand if and to what extent they wish to be supported in enabling their child’s participation in daily life.

  13. Bioactivity, mechanism of action, and cytotoxicity of copper-based nanoparticles: a review.

    Science.gov (United States)

    Ingle, Avinash P; Duran, Nelson; Rai, Mahendra

    2014-02-01

    Nanotechnology is an emerging branch of science, which has potential to solve many problems in different fields. The union of nanotechnology with other fields of sciences including physics, chemistry, and biology has brought the concept of synthesis of nanoparticles from their respective metals. Till date, many types of nanoparticles have been synthesized and being used in different fields for various applications. Moreover, copper nanoparticles attract biologists because of their significant and broad-spectrum bioactivity. Due to the large surface area to volume ratio, copper nanoparticles have been used as potential antimicrobial agent in many biomedical applications. But the excess use of any metal nanoparticles increase the chance of toxicity to humans, other living beings, and environment. In this article, we have critically reviewed the bioactivities and cytotoxicity of copper nanoparticles. We have also focused on possible mechanism involved in its interaction with microbes.

  14. Chemopreventive potential of chlorophyllin: a review of the mechanisms of action and molecular targets.

    Science.gov (United States)

    Nagini, Siddavaram; Palitti, Fabrizio; Natarajan, Adayapalam T

    2015-01-01

    Chlorophyllin (CHL), a water soluble semisynthetic derivative of the ubiquitous plant pigment chlorophyll used as a food additive, is recognized to confer a wide range of health benefits. CHL has been shown to exhibit potent antigenotoxic, anti-oxidant, and anticancer effects. Numerous experimental and epidemiological studies have demonstrated that dietary supple-mentation of CHL lowers the risk of cancer. CHL inhibits cancer initiation and progression by targeting multiple molecules and pathways involved in the metabolism of carcinogens, cell cycle progression, apoptosis evasion, invasion, and angiogenesis. The modulatory effects of CHL on the hallmark capabilities of cancer appear to be mediated via abrogation of key oncogenic signal transduction pathways such as nuclear factor kappa B, Wnt/β-catenin, and phosphatidylinositol-3-kinase/Akt signaling. This review provides insights into the molecular mechanisms of the anticancer effects of dietary CHL.

  15. Oil spill impacts on mangroves: Recommendations for operational planning and action based on a global review.

    Science.gov (United States)

    Duke, Norman C

    2016-08-30

    Mangrove tidal wetland habitats are recognised as highly vulnerable to large and chronic oil spills. This review of current literature and public databases covers the last 6 decades, summarising global data on oil spill incidents affecting, or likely to have affected, mangrove habitat. Over this period, there have been at least 238 notable oil spills along mangrove shorelines worldwide. In total, at least 5.5milliontonnes of oil has been released into mangrove-lined, coastal waters, oiling possibly up to around 1.94millionha of mangrove habitat, and killing at least 126,000ha of mangrove vegetation since 1958. However, there were assessment limitations with incomplete and unavailable data, as well as unequal coverage across world regions. To redress the gaps described here in reporting on oil spill impacts on mangroves and their recovery worldwide, a number of recommendations and suggestions are made for refreshing and updating standard operational procedures for responders, managers and researchers alike.

  16. Review: tubulin function, action of antitubulin drugs, and new drug development.

    Science.gov (United States)

    Pellegrini, Federico; Budman, Daniel R

    2005-01-01

    Anticancer agents that interfere with microtubulin function are in widespread use in man and have a broad spectrum of activity against both hematological malignancies and solid tumors. The mechanisms of actions of these agents have been better defined during the past decade, indicating that there are distinct binding sites for these agents and that they interfere with microtubulin dynamics (growth and shortening of tubules) at low concentrations and only evoke microtubulin aggregation or dissociation at high concentrations. Tubulin has been recently described in the nucleus of cells and in mitochondria. Downstream events from tubulin binding are believed to be critical events for the generation of apoptosis in the malignant cell. The effects of vinca alkaloids and taxanes are distinct, suggesting that the interference with the tubulin cap by high-affinity binding of effective agents is not the only mechanism of cytotoxic effect, and the low-affinity binding of drug, which distorts microtubulin function, may also be important. The epothilones share some of the binding characteristics of the taxanes and are in clinical trials because of cytoxic activity in taxane resistant cells. Tubulin has additional target sites for anticancer drugs including interference with the binding and function of microtubule associated proteins and interference with motor proteins which are essential for the transport of substances within the cell. Because many of these microtubule associated proteins have an ATP binding site, both computer-aided design and combinatorial chemistry techniques can be used to make agents to interfere with their function analogous to imatinib mesylate (Gleevec). Agents that interfere with the motor protein kinesin are entering clinical trials.

  17. Bacillus thuringiensis: mechanism of action, resistance, and new applications: a review.

    Science.gov (United States)

    Melo, André Luiz de Almeida; Soccol, Vanete Thomaz; Soccol, Carlos Ricardo

    2016-01-01

    Since the first report by Ishiwata in 1902 of a Bombyx mori infection, followed by the description by Berliner, Bacillus thuringiensis (Bt) has become the main microorganism used in biological control. The application of Bt to combat invertebrates of human interest gained momentum with the growing demand for food free of chemical pesticides and with the implementation of agriculture methods that were less damaging to the environment. However, the mechanisms of action of these products have not been fully elucidated. There are two proposed models: the first is that Bt causes an osmotic imbalance in response to the formation of pores in a cell membrane, and the second is that it causes an opening of ion channels that activate the process of cell death. There are various ways in which Bt resistance can develop: changes in the receptors that do not recognize the Cry toxin, the synthesis of membrane transporters that eliminate the peptides from the cytosol and the development of regulatory mechanisms that disrupt the production of toxin receptors. Besides the potential for formulation of biopesticides and the use in developing genetically modified cultivars, recent studies with Bt have discussed promising applications in other branches of science. Chitinase, an enzyme that degrades chitin, increases the efficiency of Bt insecticides, and there has been of increasing interest in the industry, given that its substrate is extremely abundant in nature. Another promising field is the potential for Bt proteins to act against cancer cells. Parasporins, toxins of Bt that do not have an entomopathogenic effect, have a cytotoxic effect on the cells changed by some cancers. This demonstrates the potential of the microorganism and new opportunities opening for future applications.

  18. Cancer Survivors in the United States: A Review of the Literature and a Call to Action

    Directory of Open Access Journals (Sweden)

    Manuel Valdivieso, Ann M. Kujawa, Tisha Jones, Laurence H. Baker

    2012-01-01

    Full Text Available Background: The number of cancer survivors in the U.S. has increased from 3 million in 1971, when the National Cancer Act was enacted, to over 12 million today. Over 70% of children affected by cancer survive more than 10 years, and most are cured. Most cancer survivors are adults, with two-thirds of them 65 years of age or older and two-thirds alive at five years. The most common cancer diagnoses among survivors include breast, prostate and colorectal cancers. This review was conducted to better appreciate the challenges associated with cancer survivors and the opportunities healthcare providers have in making a difference for these patients.Methods: Comprehensive review of literature based on PubMed searches on topics related to cancer survivorship, and associated physical, cognitive, socio-economic, sexual/behavioral and legal issues.Results: At least 50% of cancer survivors suffer from late treatment-related side effects, often including physical, psychosocial, cognitive and sexual abnormalities, as well as concerns regarding recurrence and/or the development of new malignancies. Many are chronic in nature and some are severe and even life-threatening. Survivors also face issues involving lack of appropriate health maintenance counseling, increased unemployment rate and workplace discrimination.Conclusions: Advances in the diagnosis and treatment of cancer will lead to more survivors and better quality of life. However, tools to recognize potentially serious long-lasting side effects of cancer therapy earlier in order to treat and/or prevent them must be developed. It is incumbent upon our health care delivery systems to make meeting these patients' needs a priority.

  19. Using Social Media for Actionable Disease Surveillance and Outbreak Management: A Systematic Literature Review

    Science.gov (United States)

    Charles-Smith, Lauren E.; Reynolds, Tera L.; Cameron, Mark A.; Conway, Mike; Lau, Eric H. Y.; Olsen, Jennifer M.; Pavlin, Julie A.; Shigematsu, Mika; Streichert, Laura C.; Suda, Katie J.; Corley, Courtney D.

    2015-01-01

    Objective Research studies show that social media may be valuable tools in the disease surveillance toolkit used for improving public health professionals’ ability to detect disease outbreaks faster than traditional methods and to enhance outbreak response. A social media work group, consisting of surveillance practitioners, academic researchers, and other subject matter experts convened by the International Society for Disease Surveillance, conducted a systematic primary literature review using the PRISMA framework to identify research, published through February 2013, answering either of the following questions: Can social media be integrated into disease surveillance practice and outbreak management to support and improve public health? Can social media be used to effectively target populations, specifically vulnerable populations, to test an intervention and interact with a community to improve health outcomes? Examples of social media included are Facebook, MySpace, microblogs (e.g., Twitter), blogs, and discussion forums. For Question 1, 33 manuscripts were identified, starting in 2009 with topics on Influenza-like Illnesses (n = 15), Infectious Diseases (n = 6), Non-infectious Diseases (n = 4), Medication and Vaccines (n = 3), and Other (n = 5). For Question 2, 32 manuscripts were identified, the first in 2000 with topics on Health Risk Behaviors (n = 10), Infectious Diseases (n = 3), Non-infectious Diseases (n = 9), and Other (n = 10). Conclusions The literature on the use of social media to support public health practice has identified many gaps and biases in current knowledge. Despite the potential for success identified in exploratory studies, there are limited studies on interventions and little use of social media in practice. However, information gleaned from the articles demonstrates the effectiveness of social media in supporting and improving public health and in identifying target populations for intervention. A primary recommendation resulting

  20. [Review of the effects of mindfulness meditation on mental and physical health and its mechanisms of action].

    Science.gov (United States)

    Ngô, Thanh-Lan

    2013-01-01

    Interventions based on mindfulness have become increasingly popular. This article reviews the empirical literature on its effects on mental and physical health, discusses presumed mechanisms of action as well as its proposed neurobiological underpinning. Mindfulness is associated with increased well-being as well as reduced cognitive reactivity and behavioral avoidance. It seems to contribute to enhance immune functions, diminish inflammation, diminish the reactivity of the autonomic nervous system, increase telomerase activity, lead to higher levels of plasmatic melatonin and serotonin. It enhances the quality of life for patients suffering from chronic pain, fibromylagia and HIV infection. It facilitates adaptation to the diagnosis of cancer and diabetes. It seems to lead to symptomatic improvement in irritable bowel syndrome, chronic fatigue syndrome, hot flashes, insomnia, stress related hyperphagia. It diminishes craving in substance abuse. The proposed mechanism of action are enhanced metacognitive conscience, interoceptive exposure, experiential acceptance, self-management, attention control, memory, relaxation. Six mechanism of actions for which neurological underpinnings have been published are: attention regulation (anterior cingulate cortex), body awareness (insula, temporoparietal junction), emotion regulation (modulation of the amygdala by the lateral prefrontal cortex), cognitive re-evaluation (activation of the dorsal medial prefrontal cortex or diminished activity in prefrontal regions), exposure/extinction/reconsolidation (ventromedial prefrontal cortex, hippocampus, amygdala) and flexible self-concept (prefrontal median cortex, posterior cingulated cortex, insula, temporoparietal junction). The neurobiological effects of meditation are described. These are: (1) the deactivation of the default mode network that generates spontaneous thoughts, contributes to the maintenance of the autobiographical self and is associated with anxiety and depression

  1. 75 FR 38502 - Notice of Availability of Draft Environmental Impact Statement for the Sunridge Properties in the...

    Science.gov (United States)

    2010-07-02

    ... Department of the Army Corps of Engineers Notice of Availability of Draft Environmental Impact Statement for... information pertaining to the Proposed Action and alternatives, and to disclose environmental impacts and identify mitigation measures to reduce impacts. The Proposed Action is the construction of the six...

  2. {A Review of Working Group 2 (Advanced Terrestrial Systems) of the COST 296 Action}

    Science.gov (United States)

    Warrington, E. M.; Tulunay, E.

    2009-04-01

    E.M. Warrington, E. Tulunay, N.M. Abbasi, J. Azevedo, L. Bertel, A. Bourdillon, E. Benito, C. Bianchi, A. Casimiro, L. Economou, Y. Erhel, S.M. Feeney, S.D. Gunashekar, H. Haralambous, D. Lemur, F. Marie, J.P. Monilie, M. Muriuki, M. Oger M. Pietrella, V. Rannou, H. Rothkaehl, S. Saillant, S. Salous, O. Sari, A.J. Stocker, H.J. Strangeways, Y. Tulunay and N.Y. Zaalov This paper deals with the research undertaken during the COST 296 Action in Working Group 2 on Advanced Terrestrial Systems. The Working Group comprised three work packages covering various topics: Radar and Radiolocation, HF/MF Communications, and Spectrum Management. Results from this Working Group are presented in this paper, and may be summarised as follows. Aspects of HF propagation The propagation characteristics of radio signals are important parameters to consider when designing and operating radio systems. From the point of view Working Group 2 of the COST-296 Action, interest lies with effects associated with propagation via the ionosphere of signals within the HF band. Several aspects were covered: The directions of arrival and times of flight of signals received over a path oriented along the trough have been examined and several types of propagation effects identified. Of particular note, combining the HF observations with satellite measurements has identified the presence of irregularities within the floor of the trough that result in propagation displaced from the great circle direction. An understanding of the propagation effects that result in deviations of the signal path from the great circle direction are of particular relevance to the operation of HF radiolocation systems. Inclusion of the results from the above mentioned measurements into a propagation model of the northerly ionosphere (i.e. those regions of the ionosphere located poleward of, and including, the mid-latitude trough) and the use of this model to predict the coverage expected from transmitters where the signals

  3. 76 FR 75551 - Draft Guidance for Industry on Regulatory Classification of Pharmaceutical Co-Crystals; Availability

    Science.gov (United States)

    2011-12-02

    ... nonionic interactions. Thus, pharmaceutical co-crystals offer the advantage of generating a diverse array... Pharmaceutical Co-Crystals; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The... entitled ``Regulatory Classification of Pharmaceutical Co-Crystals.'' This draft guidance...

  4. 75 FR 52357 - Request for Comment: National Center for Complementary and Alternative Medicine Draft Strategic Plan

    Science.gov (United States)

    2010-08-25

    ... for Comment: National Center for Complementary and Alternative Medicine Draft Strategic Plan ACTION: Notice. SUMMARY: The National Center for Complementary and Alternative Medicine (NCCAM) is developing its... Center for Complementary and Alternative Medicine (NCCAM) was established in 1998 with the mission of...

  5. 76 FR 58833 - Notice of Availability of the Draft Environmental Impact Statement/Environmental Impact Report...

    Science.gov (United States)

    2011-09-22

    ..., Karuk, and Yurok Tribes; Klamath Project Water Users; and other Klamath River Basin stakeholders... sustainability of all Klamath Basin communities. Statement of Purpose and Need and Proposed Action The Purpose... well as the re-construction of the City of Yreka water supply pipeline. Copies of the draft EIS/EIR are...

  6. 76 FR 75557 - Draft Environmental Impact Statement for General Management Plan/Wilderness Study, Hawaii...

    Science.gov (United States)

    2011-12-02

    .... As part of this conservation planning and environmental impact analysis effort, the Draft EIS will... managing the area over the next 15 to 20 years. The GMP will prescribe desired resource conditions and... alternatives for managing the park, including ``no-action'' and ``agency preferred'' alternatives will be...

  7. 77 FR 56817 - Notice of Public Hearings for the Draft Environmental Impact Statement for Medical Facilities...

    Science.gov (United States)

    2012-09-14

    ... actions and alternatives were evaluated within several environmental resource areas: Geology, topography... Department of the Navy Notice of Public Hearings for the Draft Environmental Impact Statement for Medical... Environmental Policy Act (NEPA) and the Council on Environmental Quality Regulations for implementing the...

  8. 77 FR 18852 - Lee Metcalf National Wildlife Refuge, Stevensville, MT; Draft Comprehensive Conservation Plan and...

    Science.gov (United States)

    2012-03-28

    ... Fish and Wildlife Service Lee Metcalf National Wildlife Refuge, Stevensville, MT; Draft Comprehensive Conservation Plan and Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability; request for comments; announcement of public meeting SUMMARY: We, the U.S. Fish and...

  9. 76 FR 16634 - Seal Beach National Wildlife Refuge, Orange County, CA; Draft Comprehensive Conservation Plan...

    Science.gov (United States)

    2011-03-24

    ... Fish and Wildlife Service Seal Beach National Wildlife Refuge, Orange County, CA; Draft Comprehensive Conservation Plan/Environmental Assessment AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of... fish and wildlife management, conservation, legal mandates, and our policies. In addition to...

  10. 77 FR 38377 - Notice of Availability of the Draft Environmental Impact Statement: Los Angeles County, CA

    Science.gov (United States)

    2012-06-27

    ... Angeles County, CA AGENCY: Federal Highway Administration (FHWA). ACTION: Notice of Availability of the... highway project in Los Angeles County, California. DATES: Public hearings for the Draft Environmental...: California Department of Transportation (Caltrans) District 7 Office, 100 South Main Street, Los Angeles,...

  11. 76 FR 40921 - Draft Guidance for Industry and Food and Drug Administration Staff; Enforcement Policy for...

    Science.gov (United States)

    2011-07-12

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Enforcement Policy for Premarket Notification Requirements for Certain In Vitro Diagnostic and Radiology Devices; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The...

  12. 77 FR 18827 - Draft Guidance for Industry on Bioequivalence Recommendations for Iron Sucrose Injection...

    Science.gov (United States)

    2012-03-28

    ... Recommendations for Iron Sucrose Injection; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice...) for iron sucrose injection. DATES: Although you can comment on any guidance at any time (see 21 CFR 10... recommendations. This notice announces the availability of draft BE recommendations for iron sucrose......

  13. 77 FR 16990 - Notification of Submission to the Secretary of Agriculture of Two Draft Regulatory Documents...

    Science.gov (United States)

    2012-03-23

    ... of Agriculture of Two Draft Regulatory Documents Under FIFRA AGENCY: Environmental Protection Agency (EPA). ] ACTION: Notification of submission to the Secretary of Agriculture. SUMMARY: This document notifies the public as required by section 25(a) of the Federal Insecticide, Fungicide, and Rodenticide...

  14. 75 FR 47346 - Draft Strategic Plan for FY 2010-2015

    Science.gov (United States)

    2010-08-05

    ... be viewed at http://www.ustreas.gov/offices/management/budget/strategic-plan/ . DATES: Written..., 2010. Martin R. Melone, Director, Strategic Planning and Performance Management, United States... Draft Strategic Plan for FY 2010-2015 AGENCY: United States Department of the Treasury. ACTION:...

  15. 76 FR 71066 - HUD Draft Environmental Justice Strategy, Extension of Public Comment Period

    Science.gov (United States)

    2011-11-16

    ...: Office of Sustainable Housing and Communities, HUD. ACTION: Notice. SUMMARY: Through this notice, HUD... Sustainable Housing and Communities, Department of Housing and Urban Development, 451 7th Street SW., Room.../sustainable_housing_communities/HUD_Draft_Environmental_Justice_Strategy . As HUD noted in the October 7,...

  16. 76 FR 68499 - Draft WaterSMART Cooperative Watershed Management Program Funding Opportunity Announcement

    Science.gov (United States)

    2011-11-04

    ... Office of the Secretary Draft WaterSMART Cooperative Watershed Management Program Funding Opportunity Announcement AGENCY: Office of the Assistant Secretary for Water and Science, Interior. ACTION: Notice of... Cooperative Watershed Management Program whose goals are to improve water quality and ecological...

  17. 76 FR 43689 - Draft Guidance for Industry and Food and Drug Administration Staff; Mobile Medical Applications...

    Science.gov (United States)

    2011-07-21

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Mobile Medical Applications; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of the...

  18. 78 FR 41069 - Medical Device Reporting for Manufacturers; Draft Guidance for Industry and Food and Drug...

    Science.gov (United States)

    2013-07-09

    ... HUMAN SERVICES Food and Drug Administration Medical Device Reporting for Manufacturers; Draft Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability...

  19. 77 FR 10753 - Draft Guidance for Industry: Food and Drug Administration Records Access Authority Under the...

    Science.gov (United States)

    2012-02-23

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Food and Drug Administration Records Access Authority Under the Federal Food, Drug, and Cosmetic Act; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is...

  20. 77 FR 74195 - Draft Guidance for Industry and Food and Drug Administration Staff; Design Considerations for...

    Science.gov (United States)

    2012-12-13

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Design Considerations for Devices Intended for Home Use; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing...

  1. 78 FR 17708 - Endangered and Threatened Wildlife and Plants; Draft Revised Supplement to the Grizzly Bear...

    Science.gov (United States)

    2013-03-22

    ... the Grizzly Bear Recovery Plan AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of document... availability of a draft Revised Supplement to the Grizzly Bear Recovery Plan. Specifically, this supplement..., Grizzly bears (Ursus arctos horribilis) are federally listed as threatened under the Endangered...

  2. Safety and health in forest harvesting operations. Diagnosis and preventive actions. A review.

    Directory of Open Access Journals (Sweden)

    P. Albizu-Urionabarrenetxea

    2013-12-01

    Full Text Available Aim of study: to review the present state of the art in relation to the main labour risks and the most relevant results of recent studies evaluating the safety and health conditions of the forest harvesting work and better ways to reduce accidents.Area of study: It focuses mainly on developed Countries, where the general concern about work risks prevention, together with the complex idiosyncrasy of forest work in forest harvesting operations, has led to a growing interest from the forest scientific and technical community.Material and Methods: The main bibliographic and Internet references have been identified using common reference analysis tools. Their conclusions and recommendations have been comprehensively summarized.Main results: Collection of the principal references and their most important conclusions relating to the main accident risk factors, their causes and consequences, the means used towards their prevention, both instrumental as well as in the aspects of training and business management, besides the influence of the growing mechanization of logging operations on those risks.Research highlights: Accident risk is higher in forest harvesting than in most other work sectors, and the main risk factors such as experience, age, seasonality, training, protective equipment, mechanization degree, etc. have been identified and studied.   The paper summarizes some relevant results, one of the principal being that the proper entrepreneurial risk management is a key factor leading to the success in minimizing labour risks.Key words: labour risk; forestry; accident rates; preventive measures; entrepreneurial risk management.

  3. A biased review of biases in Twitter studies on political collective action

    Directory of Open Access Journals (Sweden)

    Peter Cihon

    2016-08-01

    Full Text Available In recent years researchers have gravitated to Twitter and other social media platforms as fertile ground for empirical analysis of social phenomena. Social media provides researchers access to trace data of interactions and discourse that once went unrecorded in the offline world. Researchers have sought to use these data to explain social phenomena both particular to social media and applicable to the broader social world. This paper offers a minireview of Twitter-based research on political crowd behaviour. This literature offers insight into particular social phenomena on Twitter, but often fails to use standardized methods that permit interpretation beyond individual studies. Moreover, the literature fails to ground methodologies and results in social or political theory, divorcing empirical research from the theory needed to interpret it. Rather, investigations focus primarily on methodological innovations for social media analyses, but these too often fail to sufficiently demonstrate the validity of such methodologies. This minireview considers a small number of selected papers; we analyse their (often lack of theoretical approaches, review their methodological innovations, and offer suggestions as to the relevance of their results for political scientists and sociologists.

  4. Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings

    Directory of Open Access Journals (Sweden)

    Wan-Ju Yeh

    2017-01-01

    Full Text Available Advanced glycation end products (AGEs are substances composed of amino groups of proteins and reducing sugars. The initial and propagation phases of the glycation process are accompanied by the production of a large amount of free radicals, carbonyl species, and reactive dicarbonyl species, of which, methylglyoxal (MG is the most reactive and can cause dicarbonyl stress, influencing normal physiological functions. In the advanced phase, the production of AGEs and the interaction between AGEs and their receptor, RAGE, are also considered to be among the causes of chronic diseases, oxidative stress, and inflammatory reaction. Till date, multiple physiological activities of polyphenols have been confirmed. Recently, there have been many studies discussing the ability of polyphenols to suppress the MG and AGEs formation, which was also confirmed in some in vivo studies. This review article collects recent literatures concerning the effects of polyphenols on the generation of MG and AGEs through different pathways and discusses the feasibility of the inhibition of glycative stress and dicarbonyl stress by polyphenols.

  5. A biased review of biases in Twitter studies on political collective action

    Science.gov (United States)

    Cihon, Peter; Yasseri, Taha

    2016-08-01

    In recent years researchers have gravitated to Twitter and other social media platforms as fertile ground for empirical analysis of social phenomena. Social media provides researchers access to trace data of interactions and discourse that once went unrecorded in the offline world. Researchers have sought to use these data to explain social phenomena both particular to social media and applicable to the broader social world. This paper offers a minireview of Twitter-based research on political crowd behaviour. This literature offers insight into particular social phenomena on Twitter, but often fails to use standardized methods that permit interpretation beyond individual studies. Moreover, the literature fails to ground methodologies and results in social or political theory, divorcing empirical research from the theory needed to interpret it. Rather, investigations focus primarily on methodological innovations for social media analyses, but these too often fail to sufficiently demonstrate the validity of such methodologies. This minireview considers a small number of selected papers; we analyse their (often lack of) theoretical approaches, review their methodological innovations, and offer suggestions as to the relevance of their results for political scientists and sociologists.

  6. Propolis: a review of its anti-inflammatory and healing actions

    Directory of Open Access Journals (Sweden)

    A. F. N. Ramos

    2007-01-01

    Full Text Available Tissue healing is an adaptive biological response by which the organism repairs damaged tissue. The initial stage of healing is represented by an acute inflammatory reaction, in which inflammatory cells migrate to damaged tissue and phagocyte debris. At a later stage, fibroblasts and endothelial cells proliferate and generate a scar. The occurrence of inflammatory processes and healing imperfections have been a concern for hundreds of years, especially for individuals with healing difficulties, such as diabetics and carriers of peripheral circulation deficiencies. A wide variety of natural products have been used as anti-inflammatory and healing agents, with propolis being a remarkable option. Propolis has been used in popular medicine for a very long time; however, it is not a drug intended for all diseases. Currently, the determination of quality standards of propolis-containing products is a major problem due to their varying pharmacological activities and chemical compositions. The aim of this review is to discuss the use of propolis with emphasis on its anti-inflammatory and healing properties.

  7. Safety and health in forest harvesting operations. Diagnosis and preventive actions. A review

    Energy Technology Data Exchange (ETDEWEB)

    Albizu-Urionabarrenetxea, P. M.; Tolosana-Esteban, E.; Roman-Jordan, E.

    2013-07-01

    Aim of study: to review the present state of the art in relation to the main labour risks and the most relevant results of recent studies evaluating the safety and health conditions of the forest harvesting work and better ways to reduce accidents. Area of study: It focuses mainly on developed Countries, where the general concern about work risks prevention, together with the complex idiosyncrasy of forest work in forest harvesting operations, has led to a growing interest from the forest scientific and technical community. Material and Methods: The main bibliographic and Internet references have been identified using common reference analysis tools. Their conclusions and recommendations have been comprehensively summarized. Main results: Collection of the principal references and their most important conclusions relating to the main accident risk factors, their causes and consequences, the means used towards their prevention, both instrumental as well as in the aspects of training and business management, besides the influence of the growing mechanization of logging operations on those risks. Research highlights: Accident risk is higher in forest harvesting than in most other work sectors, and the main risk factors such as experience, age, seasonality, training, protective equipment, mechanization degree, etc. have been identified and studied. The paper summarizes some relevant results, one of the principal being that the proper entrepreneurial risk management is a key factor leading to the success in minimizing labour risks. (Author)

  8. Advantage of a lead swimmer in drafting

    CERN Document Server

    Westerweel, J; Pennings, P; Yilmaz, B

    2016-01-01

    We present results from model tests to investigate the effect of drafting in swimming, in particular for the lead swimmer. The drag for scaled-model passive swimmers was determined accurately at Froude numbers comparable to conditions for actual human swimmers. Several positions of a draft swimmer at different separations behind and alongside the lead swimmer were investigated. It was found that a lead swimmer can experience an advantage from a draft swimmer. Several other positions of the draft swimmer relative to the frontal wave generated by the lead swimmer were also considered. These results indicate favourable and undesirable positions during passing.

  9. 78 FR 26616 - Draft NOAA Five Year Research and Development Plan

    Science.gov (United States)

    2013-05-07

    ... leadership, workforce, partners, constituents, and Congress on how the agency's R&D creates value. This plan... Public Review. SUMMARY: NOAA's draft Five Year Research and Development Plan is available for public review and comment until June 3, 2013. This plan will guide NOAA's research and development...

  10. All-Ages Lead Model (Aalm) Version 1.05 (External Draft Report)

    Science.gov (United States)

    The All-Ages Lead Model (AALM) Version 1.05, is an external review draft software and guidance manual. EPA released this software and associated documentation for public review and comment beginning September 27, 2005, until October 27, 2005. The public comments will be accepte...

  11. Emotions predictably modify response times in the initiation of human motor actions: A meta-analytic review.

    Science.gov (United States)

    Beatty, Garrett F; Cranley, Nicole M; Carnaby, Giselle; Janelle, Christopher M

    2016-03-01

    Emotions motivate individuals to attain appetitive goals and avoid aversive consequences. Empirical investigations have detailed how broad approach and avoidance orientations are reflected in fundamental movement attributes such as the speed, accuracy, and variability of motor actions. Several theoretical perspectives propose explanations for how emotional states influence the speed with which goal directed movements are initiated. These perspectives include biological predisposition, muscle activation, distance regulation, cognitive evaluation, and evaluative response coding accounts. A comprehensive review of literature and meta-analysis were undertaken to quantify empirical support for these theoretical perspectives. The systematic review yielded 34 studies that contained 53 independent experiments producing 128 effect sizes used to evaluate the predictions of existing theories. The central tenets of the biological predisposition (Hedges' g = -0.356), distance regulation (g = -0.293; g = 0.243), and cognitive evaluation (g = -0.249; g = -0.405; g = -0.174) accounts were supported. Partial support was also identified for the evaluative response coding (g = -0.255) framework. Our findings provide quantitative evidence that substantiate existing theoretical perspectives, and provide potential direction for conceptual integration of these independent perspectives. Recommendations for future empirical work in this area are discussed.

  12. Food Classification Systems Based on Food Processing: Significance and Implications for Policies and Actions: A Systematic Literature Review and Assessment.

    Science.gov (United States)

    Moubarac, Jean-Claude; Parra, Diana C; Cannon, Geoffrey; Monteiro, Carlos A

    2014-06-01

    This paper is the first to make a systematic review and assessment of the literature that attempts methodically to incorporate food processing into classification of diets. The review identified 1276 papers, of which 110 were screened and 21 studied, derived from five classification systems. This paper analyses and assesses the five systems, one of which has been devised and developed by a research team that includes co-authors of this paper. The quality of the five systems is assessed and scored according to how specific, coherent, clear, comprehensive and workable they are. Their relevance to food, nutrition and health, and their use in various settings, is described. The paper shows that the significance of industrial food processing in shaping global food systems and supplies and thus dietary patterns worldwide, and its role in the pandemic of overweight and obesity, remains overlooked and underestimated. Once food processing is systematically incorporated into food classifications, they will be more useful in assessing and monitoring dietary patterns. Food classification systems that emphasize industrial food processing, and that define and distinguish relevant different types of processing, will improve understanding of how to prevent and control overweight, obesity and related chronic non-communicable diseases, and also malnutrition. They will also be a firmer basis for rational policies and effective actions designed to protect and improve public health at all levels from global to local.

  13. American Samoa Energy Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    Haase, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Esterly, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States); Herdrich, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bodell, Tim [National Renewable Energy Lab. (NREL), Golden, CO (United States); Visser, Charles [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-08-01

    Describes the five near-term strategies selected by the American Samoa Renewable Energy Committee (ASREC) during action planning workshops conducted in May 2013, and outlines the actions being taken to implement those strategies. Each option is tied to a priority identified in the earlier draft American Samoa Strategic Energy Plan as being an essential component of reducing American Samoa'spetroleum energy consumption. The actions described for each strategy provide a roadmap to facilitate the implementation of each strategy. This document is intended to evolve along with the advancement of the projects, and will be updated to reflect progress.

  14. Draft Legislative Proposals

    DEFF Research Database (Denmark)

    Turcan, Romeo V.; Bugaian, Larisa; Niculita, Angela;

    2015-01-01

    This chapter proposes legislative proposals for restructuring and modernization of Higher Education (HE) in Moldova. It is based on (1) the analysis of the institutional university autonomy in Moldova; (2) the benchmark analysis of institutional university autonomy in Denmark, Lithuania, Romania......, Scotland and Sweden; (3) the on-going analysis of the current situation of institutional university autonomy in Moldova, including the on-going analysis and review of the Code of Education; and (4) the European Commission agenda for the modernization of higher education. The chapter identifies...... the objectives of the legislative proposals; discusses risks and challenges that HE in Moldova faces today and in the next 10-15 years; identifies expected outcomes; identifies basic principles on which the process will be founded; proposes a new structure for the HE sector; offers an example...

  15. Draft Mission Plan Amendment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-09-01

    The Department of Energy`s Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation`s spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs.

  16. Pipe Drafting with CAD. Teacher Edition.

    Science.gov (United States)

    Smithson, Buddy

    This teacher's guide contains nine units of instruction for a course on computer-assisted pipe drafting. The course covers the following topics: introduction to pipe drafting with CAD (computer-assisted design); flow diagrams; pipe and pipe components; valves; piping plans and elevations; isometrics; equipment fabrication drawings; piping design…

  17. Data Element Dictionary: Facilities. Preliminary Draft.

    Science.gov (United States)

    Thomas, Charles R.

    The draft includes--(1) comments on file structure, (2) descriptions of dictionary organization and format, (3) alphabetical lists of elements, and (4) facilities related elements in dictionary form. The data element definitions in this draft are compatible with the Higher Education Facilities Classification and Inventory Procedures Manual, which…

  18. Book Review: Gomez, Edmund Terence, and Johan Saravanamuttu (eds (2012, The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice

    Directory of Open Access Journals (Sweden)

    Frederik Holst

    2013-01-01

    Full Text Available Book Review of the edited compilation: Gomez, Edmund Terence, and Johan Saravanamuttu (eds (2012, The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice; Singapore: NUS Press, ISBN 978-697-5832-67-3, 412 pages

  19. 29 CFR 37.94 - What corrective or remedial actions may be imposed where, after a compliance review or complaint...

    Science.gov (United States)

    2010-07-01

    ... INVESTMENT ACT OF 1998 (WIA) Compliance Procedures § 37.94 What corrective or remedial actions may be imposed... stated period of time in order to achieve voluntary compliance. (b) Such steps must include: (1) Actions... 29 Labor 1 2010-07-01 2010-07-01 true What corrective or remedial actions may be imposed...

  20. Optimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of action

    Directory of Open Access Journals (Sweden)

    Damal K

    2013-11-01

    Full Text Available Kavitha Damal, Emily Stoker, John F FoleyRocky Mountain Multiple Sclerosis Research Group, Salt Lake City, UT, USAAbstract: Multiple sclerosis (MS is a debilitating neurological disorder that affects nearly 2 million adults, mostly in their prime of youth. An environmental trigger, such as a viral infection, is hypothesized to initiate the abnormal behavior of host immune cells: to attack and damage the myelin sheath surrounding the neurons of the central nervous system. While several other pathways and disease triggers are still being investigated, it is nonetheless clear that MS is a heterogeneous disease with multifactorial etiologies that works independently or synergistically to initiate the aberrant immune responses to myelin. Although there are still no definitive markers to diagnose the disease or to cure the disease per se, research on management of MS has improved many fold over the past decade. New disease-modifying therapeutics are poised to decrease immune inflammatory responses and consequently decelerate the progression of MS disease activity, reduce the exacerbations of MS symptoms, and stabilize the physical and mental status of individuals. In this review, we describe the mechanism of action, optimal dosing, drug administration, safety, and efficacy of the disease-modifying therapeutics that are currently approved for MS therapy. We also briefly touch upon the new drugs currently under investigation, and discuss the future of MS therapeutics.Keywords: multiple sclerosis, immunomodulation, interferons, glatiramer acetate, monoclonal antibodies, dimethyl fumarate

  1. Weldon Spring Site Remedial Action Project: Report from the DOE voluntary protection program onsite review, November 17--21, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-28

    This report summarizes the Department of Energy Voluntary Protection Program (DOE-VPP) Review Team`s findings from the five-day onsite evaluation of the Weldon Spring Site Remedial Action Project (WSSRAP), conducted November 17--21, 1997. The site was evaluated against the program requirements contained in ``US Department of Energy Voluntary Protection Program, Part 1: Program Elements`` to determine its success in implementing the five tenets of DOE-VPP. DOE-VPP consists of three programs, with names and functions similar to those in OSHA`s VPP. These programs are STAR, MERIT, and DEMONSTRATION. The STAR program is the core of DOE-VPP. The program is aimed at truly outstanding protectors of employee safety and health. The MERIT program is a steppingstone for contractors and subcontractors that have good safety and health programs but need time and DOE guidance to achieve STAR status. The DEMONSTRATION program is rarely used; it allows DOE to recognize achievements in unusual situations about which DOE needs to learn more before determining approval requirements for the STAR status.

  2. 77 FR 5857 - Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft...

    Science.gov (United States)

    2012-02-06

    ...On November 2, 2011 (76 FR 67764), the U.S. Nuclear Regulatory Commission (NRC) published for public comment Draft NUREG, ``Common- Cause Failure Analysis in Event and Condition Assessment: Guidance and Research.'' The public comment period was scheduled to expire on January 31, 2012. In order to allow the public sufficient time to review and comment on the Draft NUREG, the NRC has decided to......

  3. 10 CFR 51.74 - Distribution of draft environmental impact statement and supplement to draft environmental impact...

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Distribution of draft environmental impact statement and supplement to draft environmental impact statement; news releases. 51.74 Section 51.74 Energy NUCLEAR... Impact Statements § 51.74 Distribution of draft environmental impact statement and supplement to draft...

  4. 78 FR 73555 - Deepwater Horizon Oil Spill; Draft Programmatic and Phase III Early Restoration Plan and Draft...

    Science.gov (United States)

    2013-12-06

    ... Environmental Impact Statement (Draft Phase III ERP/PEIS). The Draft Phase III ERP/PEIS considers programmatic... programmatic restoration alternatives. The Draft Phase III ERP/PEIS evaluates these restoration alternatives... the Framework Agreement. The Draft Phase III ERP/PEIS also evaluates the environmental consequences...

  5. On the Drafting of Confidentiality Agreements

    DEFF Research Database (Denmark)

    Drewsen, Merete; Lando, Henrik; Cummins, Tim

    2006-01-01

    This is not a theoretical paper but an application of existing law and economic contract theory to the issue of how to draft a specific kind of contract. It is addressed to practitioners and is intended for practical use. It will be part of a Wiki (as in Wikipedia) for contract drafting, which...... IACCM (International Association for Contract and Commercial Management) has initiated. The main theoretical aspect of the article concerns the application of the value maximization principle (the Coase theorem) to the drafting of confidentiality agreements. While the article is not theoretical, its...

  6. Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers.

    Science.gov (United States)

    Dörner, Thomas; Kinnman, Nils; Tak, Paul P

    2010-03-01

    B cell-depletion therapy, particularly using anti-CD20 treatment, has provided proof of concept that targeting B cells and the humoral response may result in clinical improvements in immune-mediated inflammatory disease. In this review, the mechanisms of action of B cell-targeting drugs are investigated, and potential biomarkers associated with response to treatment in patients with autoimmune diseases are identified. Most available data relate to B cell depletion using anti-CD20 therapy (rituximab) in patients with rheumatoid arthritis (RA). Treatment leads to significant clinical benefit, but apparently fails to deplete long-lived plasma cells, and discontinuation is associated with relapse. Biomarkers commonly used in studies of B cell-targeted therapies include rheumatoid factor, anti-citrullinated peptide antibodies, and immunoglobulin (Ig) levels. More recently, there has been interest in markers such as B cell phenotype analysis, and B lymphocyte stimulator (BLyS)/a proliferation-inducing ligand (APRIL), the latter particularly in studies of the IgG Fc-transmembrane activator and CAML interactor (TACI) fusion protein (atacicept) and anti-BLyS therapy (belimumab). Data from clinical trials of B cell-depleting agents in RA suggest that specific autoantibodies, BLyS, APRIL, and circulating and synovial B lineage cell levels may have potential as biomarkers predictive of response to treatment. Further trials validating these markers against clinical outcomes in RA are required. In patients with systemic lupus erythematosus, Fc receptors and levels of circulating immune cells (including B cells and natural killer cells) may be relevant markers.

  7. Yakima Fisheries Project : Revised Draft Environmental Impact Statement.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-05-01

    BPA proposes to fund several fishery-related activities in the Yakima River Basin. The Yakima Fisheries Project (YFP), included in the Northwest Power Planning Council`s fish and wildlife program, would be jointly managed by the State of Washington and the Yakima Indian Nation. Fisheries resources in the Yakima River are severely reduced from historical levels and there is a significant potential for enhancement of these resources. BPA`s proposed action is to fund (1) information gathering on the implementation of supplementation techniques and on feasibility of reintroducing coho salmon in an environment where native populations have become extinct; (2) research activities based on continuous assessment, feedback and improvement of research design and activities ({open_quotes}adaptive management{close_quotes}); and (3) the construction, operation, and maintenance of facilities for supplementing populations of upper Yakima spring chinook salmon. The project has been considerably revised from the original proposal described in the first draft EIS. Examined in addition to No Action (which would leave present anadromous fisheries resources unchanged in the, Basin) are two alternatives for action: (1) supplementation of depressed natural populations of upper Yakima spring chinook and (2) that same supplementation plus a study to determine the feasibility of re-establishing (via stock imported from another basin) naturally spawning population and a significant fall fishery for coho in the Yakima Basin. Alternative 2 has been identified as the preferred action. Major issues examined in the Revised Draft EIS include potential impacts of the project on genetic and ecological resources of existing fish populations, on water quality and quantity, on threatened and endangered species listed under the Endangered Species Act, and on the recreational fishery.

  8. 75 FR 30423 - Draft Comprehensive Conservation Plan and Environmental Assessment; Canaan Valley National...

    Science.gov (United States)

    2010-06-01

    ... managing this refuge for the next 15 years. Also available for public review and comment are the draft..., and on our regional planning Web site, http://www.fws.gov/northeast/planning/Canaan%20Valley/ccphome.../planning/Canaan%20Valley/ccphome.html . FOR FURTHER INFORMATION CONTACT: Jonathan Schafler, Refuge Manager...

  9. 76 FR 38414 - James Campbell National Wildlife Refuge, Honolulu County, HI; Draft Comprehensive Conservation...

    Science.gov (United States)

    2011-06-30

    ... Fish and Wildlife Service James Campbell National Wildlife Refuge, Honolulu County, HI; Draft... CCP/EA) for the James Campbell National Wildlife Refuge (Refuge), for public review and comment. The... it by any of the following methods. E-mail: FW1PlanningComments@fws.gov . Include ``James Campbell...

  10. 77 FR 27792 - Chassahowitzka National Wildlife Refuge, FL; Draft Comprehensive Conservation Plan and...

    Science.gov (United States)

    2012-05-11

    ... and the cause of waterfowl population declines on the refuge since the 1970s; (3) evaluating the... Fish and Wildlife Service Chassahowitzka National Wildlife Refuge, FL; Draft Comprehensive Conservation... Chassahowitzka National Wildlife Refuge (NWR) in Citrus and Hernando Counties, Florida, for public review and...

  11. 78 FR 35630 - Martin Dam Hydroelectric Project; Notice of Availability of the Draft Environmental Impact...

    Science.gov (United States)

    2013-06-13

    ... Energy Regulatory Commission Martin Dam Hydroelectric Project; Notice of Availability of the Draft Environmental Impact Statement for the Martin Dam Hydroelectric Project and Intention To Hold Public Meetings In... reviewed the application for license for the Martin Dam Hydroelectric Project (FERC No. 349), located...

  12. 76 FR 26718 - Gibson Dam Hydroelectric Company, LLC; Notice of Availability of Draft Environmental Assessment

    Science.gov (United States)

    2011-05-09

    ... Energy Regulatory Commission Gibson Dam Hydroelectric Company, LLC; Notice of Availability of Draft... Energy Projects has reviewed the application for license for the Gibson Dam Hydroelectric Project, located at the U.S. Department of the Interior, Bureau of Reclamation's, Gibson dam on the Sun River...

  13. 76 FR 20657 - Wells Hydroelectric Project; Notice of Availability of the Draft Environmental Impact Statement...

    Science.gov (United States)

    2011-04-13

    ... Energy Regulatory Commission Wells Hydroelectric Project; Notice of Availability of the Draft Environmental Impact Statement for the Wells Hydrolectric Project and Intention To Hold Public Meetings In... Office of Energy Projects has reviewed the application for license for the Wells Hydroelectric...

  14. The hydrodynamics of dolphin drafting

    Directory of Open Access Journals (Sweden)

    Weihs Daniel

    2004-05-01

    Full Text Available Abstract Background Drafting in cetaceans is defined as the transfer of forces between individuals without actual physical contact between them. This behavior has long been surmised to explain how young dolphin calves keep up with their rapidly moving mothers. It has recently been observed that a significant number of calves become permanently separated from their mothers during chases by tuna vessels. A study of the hydrodynamics of drafting, initiated in the hope of understanding the mechanisms causing the separation of mothers and calves during fishing-related activities, is reported here. Results Quantitative results are shown for the forces and moments around a pair of unequally sized dolphin-like slender bodies. These include two major effects. First, the so-called Bernoulli suction, which stems from the fact that the local pressure drops in areas of high speed, results in an attractive force between mother and calf. Second is the displacement effect, in which the motion of the mother causes the water in front to move forwards and radially outwards, and water behind the body to move forwards to replace the animal's mass. Thus, the calf can gain a 'free ride' in the forward-moving areas. Utilizing these effects, the neonate can gain up to 90% of the thrust needed to move alongside the mother at speeds of up to 2.4 m/sec. A comparison with observations of eastern spinner dolphins (Stenella longirostris is presented, showing savings of up to 60% in the thrust that calves require if they are to keep up with their mothers. Conclusions A theoretical analysis, backed by observations of free-swimming dolphin schools, indicates that hydrodynamic interactions with mothers play an important role in enabling dolphin calves to keep up with rapidly moving adult school members.

  15. Draft environmental statement : Proposed Valentine Wilderness area

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a draft of an analysis of the environmental impact wilderness designation would pose for the Valentine National Wildlife Refuge. Topics covered...

  16. Alaska gold rush trails study: Preliminary draft

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Preliminary study draft, with maps, of seven gold rush trails in Alaska, to determine suitability for inclusion in the National Scenic Trails system and their...

  17. The baby or the bath water? Lessons learned from the National Action Alliance for Suicide Prevention Research Prioritization Task Force literature review.

    Science.gov (United States)

    Davis Molock, Sherry; Heekin, Janet M; Matlin, Samantha G; Barksdale, Crystal L; Gray, Ekwenzi; Booth, Chelsea L

    2014-09-01

    The Research Prioritization Task Force of the National Action Alliance for Suicide Prevention conducted a comprehensive literature review of suicide prevention/intervention trials to assess the quality of the scientific evidence. A literature "review of reviews" was conducted by searching the most widely used databases for mental health and public health research. The quality of the reviews was evaluated using the Revised Assessment of Multiple Systematic Reviews system; the quality of the scientific evidence for the suicide preventions/interventions was assessed using U.S. Preventive Services Task Force criteria. The reviews were limited to peer-reviewed publications with human subjects published in English. Ninety-eight systematic reviews and 45 primary sources on suicide prevention/interventions published between January 2000 and September 2012 were evaluated. The results suggest that the quality of both the systematic reviews and the scientific evidence for suicide preventions/interventions were mixed. The majority of the systematic reviews and prevention/interventions were evaluated as fair to poor in quality. There are many promising suicide prevention/intervention trials, but research findings are often inconclusive because of methodologic problems. Methodologic problems across systematic reviews include not conducting hand searches, not surveying gray literature, and being unable to aggregate data across studies. Methodologic problems with the scientific quality of the prevention/intervention trials include paucity of information on sample demographic characteristics, poorly defined outcomes, and excluding actively suicidal participants. Suggestions for ways to improve the quality of the systematic reviews and suicide preventions/interventions are provided. Copyright © 2014 American Journal of Preventive Medicine. All rights reserved.

  18. Understanding affirmative action.

    Science.gov (United States)

    Crosby, Faye J; Iyer, Aarti; Sincharoen, Sirinda

    2006-01-01

    Affirmative action is a controversial and often poorly understood policy. It is also a policy that has been widely studied by social scientists. In this review, we outline how affirmative action operates in employment and education settings and consider the major points of controversy. In addition, we detail the contributions of psychologists and other social scientists in helping to demonstrate why affirmative action is needed; how it can have unintended negative consequences; and how affirmative action programs can be most successful. We also review how psychologists have examined variations in people's attitudes toward affirmative action, in part as a means for testing different theories of social behavior.

  19. 77 FR 74508 - Notice of Availability of the Draft Resource Management Plan Amendment, Draft Environmental...

    Science.gov (United States)

    2012-12-14

    ... Bureau of Land Management Notice of Availability of the Draft Resource Management Plan Amendment, Draft Environmental Impact Statement for the Ring of Fire Resource Management Plan--Haines Planning Area, Alaska... Management Area (ERMA) designation. The Ring of Fire RMP ROD also deferred to a subsequent planning effort...

  20. 77 FR 42756 - Draft Environmental Impact Statement and Draft Habitat Conservation Plan for Incidental Take of...

    Science.gov (United States)

    2012-07-20

    ... Texas troglobitic water slater (Lirceolus smithii) in case they are listed during the duration of the..., and the Edwards Aquifer Authority; San Antonio Water Systems; City of New Braunfels, Texas; City of... Fish and Wildlife Service Draft Environmental Impact Statement and Draft Habitat Conservation Plan for...

  1. 77 FR 27461 - Draft Guidance for Industry and Food and Drug Administration Staff; Pediatric Information for X...

    Science.gov (United States)

    2012-05-10

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Pediatric Information for X-Ray Imaging Device Premarket Notifications; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  2. 75 FR 57055 - Endangered and Threatened Wildlife and Plants; Draft Revised Recovery Plan for Utah Prairie Dog

    Science.gov (United States)

    2010-09-17

    ... for Utah Prairie Dog AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of document... availability of a draft revised recovery plan for the Utah prairie dog (Cynomys parvidens). This species is.... The Utah prairie dog (Cynomys parvidens), found only in southwestern and central Utah, was listed...

  3. 77 FR 48159 - Draft Guidance for Industry and Food and Drug Administration Staff; Refuse To Accept Policy for...

    Science.gov (United States)

    2012-08-13

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Refuse To Accept Policy for 510(k)s; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of...

  4. 76 FR 22724 - Draft Program Environmental Impact Statement/Environmental Impact Report (PEIS/R) and Public...

    Science.gov (United States)

    2011-04-22

    ...) to reduce or avoid adverse water supply impacts to all of the Friant Division long-term contractors... alternatives considered in the Draft PEIS/R include actions that will be implemented to work towards achieving... contracts between the United States and the Central Valley Project (CVP) Friant Division contractors....

  5. 78 FR 19002 - Marine Mammal Protection Act; Draft Revised Stock Assessment Reports for Two Stocks of West...

    Science.gov (United States)

    2013-03-28

    ...: March 14, 2013. Stephen Guertin, Deputy Director, Fish and Wildlife Service. BILLING CODE 4310-55-P ... Fish and Wildlife Service Marine Mammal Protection Act; Draft Revised Stock Assessment Reports for Two Stocks of West Indian Manatee AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of...

  6. 75 FR 1401 - Notice of Intent To Prepare a Draft Environmental Impact Statement for the Baldwin Hills Crenshaw...

    Science.gov (United States)

    2010-01-11

    ... Public Utilities (Wastewater, Water, Solid Waste, and Energy Conservation). Lead Agencies As a lead... URBAN DEVELOPMENT Notice of Intent To Prepare a Draft Environmental Impact Statement for the Baldwin... Planning and Development, HUD. ACTION: Notice. SUMMARY: The Department of Housing and Urban Development...

  7. 76 FR 70768 - Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft...

    Science.gov (United States)

    2011-11-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft... November 2, 2011 (76 FR 67764). This action is necessary to correct an erroneous date for submission...

  8. 77 FR 42487 - Intent To Prepare a Draft Environmental Impact Statement To Reduce Avian Predation on Juvenile...

    Science.gov (United States)

    2012-07-19

    ... Department of the Army; Corps of Engineers Intent To Prepare a Draft Environmental Impact Statement To Reduce.... ACTION: Notice of intent. SUMMARY: The U.S. Army Corps of Engineers, Portland District (Corps), intends..., habitat alterations and lethal removal. Also, per the National Environmental Policy Act regulations...

  9. 76 FR 77542 - Draft Guidance for Industry and Food and Drug Administration Staff on Humanitarian Use Device...

    Science.gov (United States)

    2011-12-13

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff on Humanitarian Use Device Designations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a...

  10. 78 FR 60292 - Draft Guidance for Industry on Abbreviated New Drug Application Submissions-Refuse-to-Receive...

    Science.gov (United States)

    2013-10-01

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Abbreviated New Drug Application Submissions--Refuse-to-Receive Standards; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a...

  11. 76 FR 28688 - Draft Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls...

    Science.gov (United States)

    2011-05-18

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 866 Draft Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: In Vitro Diagnostic Devices for Bacillus Species Detection AGENCY: Food and Drug Administration, HHS. ACTION: Notice of...

  12. 75 FR 59726 - Draft Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls...

    Science.gov (United States)

    2010-09-28

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Herpes Simplex Virus Types 1 and 2 Serological Assays; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food...

  13. 76 FR 66734 - National Institute on Deafness and Other Communication Disorders Draft 2012-2016 Strategic Plan

    Science.gov (United States)

    2011-10-27

    ... Disorders Draft 2012-2016 Strategic Plan AGENCY: National Institute on Deafness and Other Communication...). ACTION: Notice. SUMMARY: The National Institute on Deafness and Other Communication Disorders (NIDCD... communication impairments or disorders; and supports efforts to create devices that substitute for lost and...

  14. 75 FR 78268 - Draft NIJ Selection and Application Guide to Ballistic-Resistant Body Armor for Law Enforcement...

    Science.gov (United States)

    2010-12-15

    ... Law Enforcement, Corrections, and Public Safety AGENCY: National Institute of Justice. ACTION: Notice of Draft NIJ Selection and Application Guide to Ballistic-Resistant Body Armor for Law Enforcement... for Law Enforcement, Corrections, and Public Safety.'' The opportunity to provide comments on this...

  15. 75 FR 52555 - Notice of Availability of a Draft Site-Specific Environmental Assessment and Notice of Public...

    Science.gov (United States)

    2010-08-26

    ..., junction boxes, electric power generation (solar, wind, and/or fuel cell,), and two-way communications... the availability of the Draft SSEA for the OOI, and requests public review and comment on the document... hearing at each of the locations listed below and will allow individuals to review the...

  16. 75 FR 50008 - Notice of Availability of a Draft Site-Specific Environmental Assessment and Notice of Public...

    Science.gov (United States)

    2010-08-16

    ..., junction boxes, electric power generation (solar, wind, and/or fuel cell,), and two-way communications...) gives notice of the availability of the Draft SSEA for the OOI, and requests public review and comment... scheduled public hearing at each of the locations listed below and will allow individuals to review...

  17. 集体行动的理论综述%Review on the theory of the collective action

    Institute of Scientific and Technical Information of China (English)

    王清华

    2013-01-01

    Collective action is one of the focuses of people always concern.Especially in the field of sociology, structuralism, utilitarianism and construction principle of collective action to make a theoretical explanation;in the field of economics, research on collective action is just beginning, especially the research of it is still lack of specific economic phenomenon in the collective action.As a sort of collective action theory from aspects of sociology and economics of two party, in order to study the specific economic phenomenon has guiding significance.%  集体行动是人们历来关注的焦点之一。特别是在社会学领域,结构主义、功利主义和构建主义都对集体行动做出了理论上的解释;在经济学界,对于集体行动的研究还刚刚开始,特别是还缺少针对具体经济现象中的集体行动的研究。从社会学和经济学两方面对研究集体行动的理论做一个梳理,以期对研究具体的经济现象有所指导意义。

  18. Indiana Bat (Myotis sodalis) Draft Recovery Plan: First Revision

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — U.S. Fish and Wildlife Service's Draft recovery plan for Indiana bats, a Federally endangered species. First revision. The purpose of this draft recovery plan is to...

  19. 75 FR 48973 - Draft Guidance for Industry: Prevention of Salmonella

    Science.gov (United States)

    2010-08-12

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Prevention of Salmonella... availability of a draft guidance entitled ``Prevention of Salmonella Enteritidis in Shell Eggs During... ``Prevention of Salmonella Enteritidis in Shell Eggs During Production, Storage, and Transportation''...

  20. Draft national health policy 2015: A critical appraisal

    Directory of Open Access Journals (Sweden)

    Faruque U Ahmed

    2016-01-01

    Full Text Available Revising a health policy of any country is a periodic procedure dependent on the change of demographic profile, current health status of the population including epidemiological changes in disease prevalence pattern, and progress made under the earlier policies. Along with it, newer research revelation of the natural history of the existing and emerging health problems, availability of newer technology as well as changing sociopolitical commitment to improve the health status of the population are the driving forces in the change of policy. Draft National Health Policy (NHP 2015 is an attempt for the same. A review of the draft has been undertaken. The chapter on introduction is crisp and clear. Situation analysis of the draft is sketchy and without any reference of sources. Shifting the health goal is without any basis, and the objectives defined for the policy change are incongruous with the introduction. A detailed description does not give a clear picture but rather confuses the reader as it talks of comprehensive universal health-care services to be provided with a holistic concept but maximum emphasis is made in the implementation of a national program. Private health-care services are an area to reckon but except for mere references on the involvement in private-public mode, nothing concrete is observed, especially in the primary care level. Involvement envisaged in the secondary and tertiary levels is nebulous. The implementation health insurance program as well as regulatory mechanISM with the existing is also not defined exclusively in the context of a newer health policy.

  1. 78 FR 59412 - Bureau of Oceans and International Environmental Scientific Affairs; Climate Action Report

    Science.gov (United States)

    2013-09-26

    ... of Oceans and International Environmental Scientific Affairs; Climate Action Report AGENCY... Climate Action Report (CAR) on U.S. climate change actions. This draft CAR consists of two documents, the National Communication and the Biennial Report, that respond to reporting requirements under the...

  2. Analytics4Action Evaluation Framework: A Review of Evidence-Based Learning Analytics Interventions at the Open University UK

    Science.gov (United States)

    Rienties, Bart; Boroowa, Avinash; Cross, Simon; Kubiak, Chris; Mayles, Kevin; Murphy, Sam

    2016-01-01

    There is an urgent need to develop an evidence-based framework for learning analytics whereby stakeholders can manage, evaluate, and make decisions about which types of interventions work well and under which conditions. In this article, we will work towards developing a foundation of an Analytics4Action Evaluation Framework (A4AEF) that is…

  3. 78 FR 2210 - Review of New Sources and Modifications in Indian Country: Notice of Action Partially Granting...

    Science.gov (United States)

    2013-01-10

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Parts 49 and 51 RIN 2060-AH37 Review of New Sources and Modifications in Indian Country... of certain provisions of the rule titled, ``Review of New Sources and Modifications in Indian...

  4. 75 FR 57956 - Draft Revision of the Federalwide Assurance

    Science.gov (United States)

    2010-09-23

    ... HUMAN SERVICES Draft Revision of the Federalwide Assurance AGENCY: Department of Health and Human... Assistant Secretary for Health, is announcing the availability of the draft revised Federalwide Assurance (FWA) form and Terms of Assurance, and is seeking comment on these draft documents. OHRP is...

  5. 76 FR 9209 - Draft NOAA National Aquaculture Policy

    Science.gov (United States)

    2011-02-16

    ... National Aquaculture Policy and Draft DOC National Aquaculture Policy; Notices #0;#0;Federal Register / Vol... and Atmospheric Administration RIN 0648-XA214 Draft NOAA National Aquaculture Policy AGENCY: National...: Notice of availability of draft aquaculture policy; request for comments. SUMMARY: NOAA is seeking...

  6. 77 FR 5528 - Trust Land Consolidation Draft Plan

    Science.gov (United States)

    2012-02-03

    ... Office of the Secretary Trust Land Consolidation Draft Plan AGENCY: Office of the Secretary, Interior... fractional interests in these lands. We are seeking comments on the draft plan for accomplishing these goals. DATES: Submit comments by March 19, 2012. ADDRESSES: Send comments on the draft plan to: Elizabeth...

  7. External Peer Review Team Report for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nye County, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Marutzky, Sam J. [Navarro-Intera, LLC (N-I), Las Vegas, NV (United States); Andrews, Robert [Navarro-Intera, LLC (N-I), Las Vegas, NV (United States)

    2015-01-01

    The peer review team commends the Navarro-Intera, LLC (N-I), team for its efforts in using limited data to model the fate of radionuclides in groundwater at Yucca Flat. Recognizing the key uncertainties and related recommendations discussed in Section 6.0 of this report, the peer review team has concluded that U.S. Department of Energy (DOE) is ready for a transition to model evaluation studies in the corrective action decision document (CADD)/corrective action plan (CAP) stage. The DOE, National Nuclear Security Administration Nevada Field Office (NNSA/NFO) clarified the charge to the peer review team in a letter dated October 9, 2014, from Bill R. Wilborn, NNSA/NFO Underground Test Area (UGTA) Activity Lead, to Sam J. Marutzky, N-I UGTA Project Manager: “The model and supporting information should be sufficiently complete that the key uncertainties can be adequately identified such that they can be addressed by appropriate model evaluation studies. The model evaluation studies may include data collection and model refinements conducted during the CADD/CAP stage. One major input to identifying ‘key uncertainties’ is the detailed peer review provided by independent qualified peers.” The key uncertainties that the peer review team recognized and potential concerns associated with each are outlined in Section 6.0, along with recommendations corresponding to each uncertainty. The uncertainties, concerns, and recommendations are summarized in Table ES-1. The number associated with each concern refers to the section in this report where the concern is discussed in detail.

  8. Twenty-Five Years of Ecological Recovery of East Fork Poplar Creek: Review of Environmental Problems and Remedial Actions

    Energy Technology Data Exchange (ETDEWEB)

    Smith, John G [ORNL; Loar, James M [ORNL; Stewart, Arthur J [ORNL

    2011-01-01

    In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Department of Energy s Y-12 National Security Complex (Y-12 Complex) in Oak Ridge, Tennessee, USA, allowing discharge of effluents to East Fork Poplar Creek (EFPC). The effluents ranged from large volumes of chlorinated oncethrough cooling water and cooling tower blow-down to smaller discharges of treated and untreated process wastewaters, which contained a mixture of heavy metals, organics, and nutrients, especially nitrates. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to meet two major objectives: demonstrate that the established effluent limitations were protecting the classified uses of EFPC, and document the ecological effects resulting from implementing a Water Pollution Control Program at the Y-12 Complex. The second objective is the primary focus of the other papers in this special series. This paper provides a history of pollution and the remedial actions that were implemented; describes the geographic setting of the study area; and characterizes the physicochemical attributes of the sampling sites, including changes in stream flow and temperature that occurred during implementation of the BMAP. Most of the actions taken under the Water Pollution Control Program were completed between 1986 and 1998, with as many as four years elapsing between some of the most significant actions. The Water Pollution Control Program included constructing nine new wastewater treatment facilities and implementation of several other pollution-reducing measures, such as a best management practices plan; area-source pollution control management; and various spill-prevention projects. Many of the major actions had readily discernable effects on the chemical and physical conditions of EFPC. As controls on effluents entering the stream were implemented, pollutant concentrations generally declined and, at least initially, the volume of water

  9. Twenty-Five Years of Ecological Recovery of East Fork Poplar Creek: Review of Environmental Problems and Remedial Actions

    Science.gov (United States)

    Loar, James M.; Stewart, Arthur J.; Smith, John G.

    2011-06-01

    In May 1985, a National Pollutant Discharge Elimination System permit was issued for the Department of Energy's Y-12 National Security Complex (Y-12 Complex) in Oak Ridge, Tennessee, USA, allowing discharge of effluents to East Fork Poplar Creek (EFPC). The effluents ranged from large volumes of chlorinated once-through cooling water and cooling tower blow-down to smaller discharges of treated and untreated process wastewaters, which contained a mixture of heavy metals, organics, and nutrients, especially nitrates. As a condition of the permit, a Biological Monitoring and Abatement Program (BMAP) was developed to meet two major objectives: demonstrate that the established effluent limitations were protecting the classified uses of EFPC, and document the ecological effects resulting from implementing a Water Pollution Control Program at the Y-12 Complex. The second objective is the primary focus of the other papers in this special series. This paper provides a history of pollution and the remedial actions that were implemented; describes the geographic setting of the study area; and characterizes the physicochemical attributes of the sampling sites, including changes in stream flow and temperature that occurred during implementation of the BMAP. Most of the actions taken under the Water Pollution Control Program were completed between 1986 and 1998, with as many as four years elapsing between some of the most significant actions. The Water Pollution Control Program included constructing nine new wastewater treatment facilities and implementation of several other pollution-reducing measures, such as a best management practices plan; area-source pollution control management; and various spill-prevention projects. Many of the major actions had readily discernable effects on the chemical and physical conditions of EFPC. As controls on effluents entering the stream were implemented, pollutant concentrations generally declined and, at least initially, the volume of water

  10. On the origins of human handedness and language: a comparative review of hand preferences for bimanual coordinated actions and gestural communication in nonhuman primates.

    Science.gov (United States)

    Meguerditchian, Adrien; Vauclair, Jacques; Hopkins, William D

    2013-09-01

    Within the evolutionary framework about the origin of human handedness and hemispheric specialization for language, the question of expression of population-level manual biases in nonhuman primates and their potential continuities with humans remains controversial. Nevertheless, there is a growing body of evidence showing consistent population-level handedness particularly for complex manual behaviors in both monkeys and apes. In the present article, within a large comparative approach among primates, we will review our contribution to the field and the handedness literature related to two particular sophisticated manual behaviors regarding their potential and specific implications for the origins of hemispheric specialization in humans: bimanual coordinated actions and gestural communication. Whereas bimanual coordinated actions seem to elicit predominance of left-handedness in arboreal primates and of right-handedness in terrestrial primates, all handedness studies that have investigated gestural communication in several primate species have reported stronger degree of population-level right-handedness compared to noncommunicative actions. Communicative gestures and bimanual actions seem to affect differently manual asymmetries in both human and nonhuman primates and to be related to different lateralized brain substrates. We will discuss (1) how the data of hand preferences for bimanual coordinated actions highlight the role of ecological factors in the evolution of handedness and provide additional support the postural origin theory of handedness proposed by MacNeilage [MacNeilage [2007]. Present status of the postural origins theory. In W. D. Hopkins (Ed.), The evolution of hemispheric specialization in primates (pp. 59-91). London: Elsevier/Academic Press] and (2) the hypothesis that the emergence of gestural communication might have affected lateralization in our ancestor and may constitute the precursors of the hemispheric specialization for language.

  11. Supplement to the Surplus Plutonium Disposition Draft Environmental Impact Statement

    Energy Technology Data Exchange (ETDEWEB)

    N/A

    1999-05-14

    services. The procurement process included the environmental review specified in DOE's NEPA regulations in 10 CFR 1021.216. The six reactors selected are Catawba Nuclear Station Units 1 and 2 in South Carolina McGuire Nuclear Station Units 1 and 2 in North Carolina, and North Anna Power Station Units 1 and 2 in Virginia. The Supplement describes the potential environmental impacts of using MOX fuel in these six specific reactors named in the DCS proposal as well as other program changes made since the SPD Draft EIS was published.

  12. Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: a review of the protective action of melatonin

    Energy Technology Data Exchange (ETDEWEB)

    Gultekin, Fatih; Hicyilmaz, Hicran [Suleyman Demirel University, School of Medicine, Department of Biochemistry, Isparta (Turkey)

    2007-10-15

    This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage. (orig.)

  13. A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

    OpenAIRE

    Hao Sun; Guangwen Luo; Dahui Chen; Zheng Xiang

    2016-01-01

    AbstractRhein is a major medicinal ingredient isolated from several traditional Chinese medicines, including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and Polygonum multiflorum Thunb. Rhein has various pharmacological activities, such as anti-inflammatory, antitumor, antioxidant, antifibrosis, hepatoprotective, and nephroprotective activities. Although more than 100 articles in PubMed are involved in the pharmacological mechanism of action of rhein, only a few foc...

  14. Review of decision methodologies for evaluating regulatory actions affecting public health and safety. [Nuclear industry site selection

    Energy Technology Data Exchange (ETDEWEB)

    Hendrickson, P.L.; McDonald, C.L.; Schilling, A.H.

    1976-12-01

    This report examines several aspects of the problems and choices facing the governmental decision maker who must take regulatory actions with multiple decision objectives and attributes. Particular attention is given to the problems facing the U.S. Nuclear Regulatory Commission (NRC) and to the decision attribute of chief concern to NRC, the protection of human health and safety, with emphasis on nuclear power plants. The study was undertaken to provide background information for NRC to use in refining its process of value/impact assessment of proposed regulatory actions. The principal conclusion is that approaches to rationally consider the value and impact of proposed regulatory actions are available. These approaches can potentially improve the decision-making process and enable the agency to better explain and defend its decisions. They also permit consistent examination of the impacts, effects of uncertainty and sensitivity to various assumptions of the alternatives being considered. Finally, these approaches can help to assure that affected parties are heard and that technical information is used appropriately and to the extent possible. The principal aspects of the regulatory decision problem covered in the report are: the legal setting for regulatory decisions which affect human health and safety, elements of the decision-making process, conceptual approaches to decision making, current approaches to decision making in several Federal agencies, and the determination of acceptable risk levels.

  15. Geothermal Program Review XII: proceedings. Geothermal Energy and the President's Climate Change Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-12-31

    Geothermal Program Review XII, sponsored by the Geothermal Division of US Department of Energy, was held April 25--28, 1994, in San Francisco, California. This annual conference is designed to promote effective technology transfer by bringing together DOE-sponsored researchers; utility representatives; geothermal energy developers; suppliers of geothermal goods and services; representatives from federal, state, and local agencies; and others with an interest in geothermal energy. In-depth reviews of the latest technological advancements and research results are presented during the conference with emphasis on those topics considered to have the greatest potential to impact the near-term commercial development of geothermal energy.

  16. Draft Genome Sequence of Lactobacillus rhamnosus 2166.

    OpenAIRE

    Karlyshev, Andrey V.; Melnikov, Vyacheslav G.; Kosarev, Igor V.; Abramov, Vyacheslav M.

    2014-01-01

    In this report, we present a draft sequence of the genome of Lactobacillus rhamnosus strain 2166, a potential novel probiotic. Genome annotation and read mapping onto a reference genome of L. rhamnosus strain GG allowed for the identification of the differences and similarities in the genomic contents and gene arrangements of these strains.

  17. On the Drafting of Confidentiality Agreements

    DEFF Research Database (Denmark)

    Drewsen, Merete; Lando, Henrik; Cummins, Tim

    2006-01-01

    IACCM (International Association for Contract and Commercial Management) has initiated. The main theoretical aspect of the article concerns the application of the value maximization principle (the Coase theorem) to the drafting of confidentiality agreements. While the article is not theoretical, its...

  18. 78 FR 53792 - Draft Guidance for Reciprocity

    Science.gov (United States)

    2013-08-30

    ...The U.S. Nuclear Regulatory Commission (NRC) is revising its licensing guidance for reciprocity. The NRC is requesting public comment on draft NUREG-1556, Volume 19, Revision 1, ``Consolidated Guidance about Materials Licenses: Guidance for Agreement State Licensees about NRC Form 241 `Report of Proposed Activities in Non- Agreement States, Areas of Exclusive Federal Jurisdiction, of Offshore......

  19. CENELEC Project Report Smart House Roadmap (draft)

    NARCIS (Netherlands)

    Hartog, F.T.H. den; Suters, T.; Parsons, J.; Faller, J.

    2010-01-01

    This CENELEC project report has been drafted by a project team and steering group of representatives of interested parties and is to be endorsed on 2010-11-23. Neither the national members of CENELEC nor the CEN-CENELEC Management Centre can be held accountable for the technical content of this CENE

  20. Drafting. Advanced Print Reading--Electrical.

    Science.gov (United States)

    Oregon State Dept. of Education, Salem.

    This document is a workbook for drafting students learning advanced print reading for electricity applications. The workbook contains seven units covering the following material: architectural working drawings; architectural symbols and dimensions; basic architectural electrical symbols; wiring symbols; riser diagrams; schematic diagrams; and…

  1. Draft Genome Sequence of Lactobacillus rhamnosus 2166.

    OpenAIRE

    Karlyshev, Andrey V.; Melnikov, Vyacheslav G.; Kosarev, Igor V.; Abramov, Vyacheslav M.

    2014-01-01

    In this report, we present a draft sequence of the genome of Lactobacillus rhamnosus strain 2166, a potential novel probiotic. Genome annotation and read mapping onto a reference genome of L. rhamnosus strain GG allowed for the identification of the differences and similarities in the genomic contents and gene arrangements of these strains.

  2. Provider Services Network Project. Draft Final Report.

    Science.gov (United States)

    Urban and Rural Systems Associates, San Francisco, CA.

    This draft report on the development and testing of a child care Provider Services Network (PSN) model in Santa Clara County, California, includes a handbook (Manual to Optimize a PSN) designed to provide the State Department of Education and regional or local child care coordinating agencies with information needed to develop PSN optimization…

  3. Public policy, health system, and community actions against illness as platforms for response to NCDs in Tanzania : a narrative review

    NARCIS (Netherlands)

    Metta, Emmy; Msambichaka, Beverly; Mwangome, Mary; Nyato, Daniel J; Dieleman, Marjolein; Haisma, Hinke; Klatser, Paul; Geubbels, Eveline

    2014-01-01

    BACKGROUND: Most low- and middle- income countries are facing a rise of the burden of non-communicable diseases (NCDs) alongside the persistent burden of infectious diseases. This narrative review aims to provide an inventory of how the existing policy environment, health system, and communities are

  4. Public policy, health system, and community actions against illness as platforms for response to NCDs in Tanzania : a narrative review

    NARCIS (Netherlands)

    Metta, Emmy; Msambichaka, Beverly; Mwangome, Mary; Nyato, Daniel J; Dieleman, Marjolein; Haisma, Hinke; Klatser, Paul; Geubbels, Eveline

    2014-01-01

    BACKGROUND: Most low- and middle- income countries are facing a rise of the burden of non-communicable diseases (NCDs) alongside the persistent burden of infectious diseases. This narrative review aims to provide an inventory of how the existing policy environment, health system, and communities are

  5. CFD modeling of a spouted bed with a porous draft tube

    Institute of Scientific and Technical Information of China (English)

    Salar Azizi; Seyyed Hossein Hosseini; M. Moraveji; Goodarz Ahmadi

    2010-01-01

    Spouted bed with a porous draft tube is used for drying of grains and chemical products and thermal disinfestations process. This work provides a computational fluid dynamics (CFD) simulation of binary mixtures of glass particles in a spouted bed with a porous draft tube. The simulation used the multi-fluid Eulerian-Eulerian approach based on kinetic theory of granular flows, incorporating a kinetic-frictional constitutive model for dense assemblies of particulate solids and Gidaspow's drag model for the inter-action between gas and particles. Influences of solids mass fraction and inlet gas flow rate on pressure distribution, gas and particle velocities were studied. The modeling results were compared with the exper-imental work of Ishikura, Nagashima, and lde (2003) for the flow condition along the axis of the spouted bed. Good agreement between the modeling results and experimental data was observed.

  6. 76 FR 14402 - Draft Action Plan-A Public Health Action Plan To Combat Antimicrobial Resistance

    Science.gov (United States)

    2011-03-16

    ... resistance (AR) in recognition of the increasing importance of AR as a public health threat. The Task Force..., fungi, and parasites) and settings (human medicine, veterinary medicine, agriculture, animal production...

  7. 76 FR 21907 - Draft Action Plan-A Public Health Action Plan To Combat Antimicrobial Resistance

    Science.gov (United States)

    2011-04-19

    ... the increasing importance of AR as a public health threat. The Task Force is co-chaired by the Centers... spectrum of AR issues, addressing resistance in a wide range of pathogens (bacteria, viruses, fungi, and...

  8. IMPLICATIONS OF THE CURRENT EXPOSURE DRAFT ON AUDIT REPORTING

    Directory of Open Access Journals (Sweden)

    George Silviu CORDOȘ

    2015-04-01

    Full Text Available The regulatory changes come as a response to perceived deficiencies in the postfinancial crisis, and their goal is to improve users' perception of the usefulness and quality of the audit report. The article approaches the subject of these proposals to revise the standards and their implications for the audit report. The article is divided into five parts: the first part the authors present a brief introduction to the subject matter; the second part presents the research methodology; the third part the authors present a review of the literature research; the fourth section presents an analysis of the responses of EU respondents to the Exposure Draft issued by the IAASB in July 2013 and the last part the authors present research findings, limitations and perspectives.

  9. 76 FR 72006 - Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon...

    Science.gov (United States)

    2011-11-21

    ... COMMISSION Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon... Recovery Facility Surveys of Radon and Radon Progeny in Air and Demonstrations of Compliance with 10 CFR 20... that existing guidance does not sufficiently detail how the NRC staff reviews surveys of radon and...

  10. 75 FR 35800 - Draft EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments

    Science.gov (United States)

    2010-06-23

    ... AGENCY Draft EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments... Dioxin Toxicity and Response to NAS Comments'' (EPA/600/R-10/038A) for independent external review, and... Sciences (NAS) 2006 report. In addition, it includes new analyses on potential human effects that...

  11. 75 FR 16499 - Notice of Availability of a Technical Agency Draft Recovery Plan for Pyne's Ground-Plum...

    Science.gov (United States)

    2010-04-01

    ... under the Act (16 U.S.C. 1531 et seq.), on September 26, 1991 (56 FR 48748). This species is a rare... Ground-Plum (Astragalus bibullatus) for Review and Comment AGENCY: Fish and Wildlife Service, Interior...-plum (Astragalus bibullatus), a species endemic to the Central Basin in Tennessee. The draft...

  12. 77 FR 51527 - Notice of Extension of Public Comment Period for the Draft Environmental Impact Statement for the...

    Science.gov (United States)

    2012-08-24

    ... review at the following public libraries: Ida Hilton Public Library, 1105 North Way, Darien, GA, 31305; Long County Public Library, 28 S. Main Street, Ludowici, GA, 31316; and Hog Hammock Public Library... Department of the Navy Notice of Extension of Public Comment Period for the Draft Environmental Impact...

  13. 78 FR 23548 - Extension of Public Comment Period for the Draft Environmental Impact Statement for U.S. Navy F...

    Science.gov (United States)

    2013-04-19

    ... copies of the Draft EIS are available for public review at the following libraries: 1. City of El Centro Public Library, 1140 North Imperial Avenue, El Centro, California 92243. 2. City of Imperial Public... Branch, 401 North Douty Street, Hanford, California 93230. 8. Fresno County Public Library, Central...

  14. [Comments of the State of Colorado on the U.S. Fish and Wildlife Service Draft Biomonitoring Program for Rocky Mountain Arsenal - Aquatic Ecosystems : Addendum to Amendment 5 of the 1994 Fish and Wildlife Management Plan : September, 1994

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Colorado Department of Public Health and Environment reviewed the USFWS's draft plan for the aquatic portion of the Service's biomonitoring program, dated...

  15. An Interim Report on NASA's Draft Space Technology Roadmaps

    Science.gov (United States)

    2011-01-01

    NASA has developed a set of 14 draft roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist (OCT). Each of these roadmaps focuses on a particular technology area (TA). The roadmaps are intended to foster the development of advanced technologies and concepts that address NASA's needs and contribute to other aerospace and national needs. OCT requested that the National Research Council conduct a study to review the draft roadmaps, gather and assess relevant community input, and make recommendations and suggest priorities to inform NASA's decisions as it finalizes its roadmaps. The statement of task states that "based on the results of the community input and its own deliberations, the steering committee will prepare a brief interim report that addresses high-level issues associated with the roadmaps, such as the advisability of modifying the number or technical focus of the draft NASA roadmaps." This interim report, which does not include formal recommendations, addresses that one element of the study charge. NASA requested this interim report so that it would have the opportunity to make an early start in modifying the draft roadmaps based on feedback from the panels and steering committee. The final report will address all other tasks in the statement of task. In particular, the final report will include a prioritization of technologies, will describe in detail the prioritization process and criteria, and will include specific recommendations on a variety of topics, including many of the topics mentioned in this interim report. In developing both this interim report and the final report to come, the steering committee draws on the work of six study panels organized by technical area, loosely following the organization of the 14 roadmaps, as follows: A Panel 1: Propulsion and Power TA01 Launch Propulsion Systems TA02 In-Space Propulsion Technologies TA03 Space Power and Energy Storage Systems TA13

  16. Drugs affecting the inner ear. A review of their clinical efficacy, mechanisms of action, toxicity, and place in therapy.

    Science.gov (United States)

    Norris, C H

    1988-12-01

    Many drugs have a site of action within the inner ear. The list includes therapeutic, diagnostic and ototoxic agents. Therapeutic agents are most useful in cases of infections, endolymphatic hydrops, vascular insufficiency, vertigo of peripheral origin, autoimmune disease, otosclerosis (otospongiosis), sudden hearing loss and tinnitus. For infections, the most widely used anti-microbial agents are the penicillins and cephalosporins. There are no antiviral agents that have been proven useful for inner ear viral infections. However, steroids have been of some value for controlling some of the sequelae. Steroids have also been useful in conjunction with ampicillin in cases of syphilitic hearing loss. In cases of endolymphatic hydrops, the diuretics chlorthalidone, hydrochlorothiazide and acetazolamide have been useful. When diuretic and diet therapy cannot control endolymphatic hydrops, ototoxic drugs such as streptomycin have been used. In cases of vascular insufficiency within the inner ear, vasodilators such as carbon dioxide, papaverine, buphenine (nylidrin), naftidrofuryl (nafronyl) and thymoxamine have been recommended, but their true efficacy is questionable. Some success with betahistine has been achieved but the mechanism of this drug's action may be other than vasodilatation. Vertigo is best controlled with antihistamines and anticholinergics and with certain calcium channel blockers. Autoimmune inner ear disease appears to respond to a combination of steroids and cyclophosphamide. Although controversial, current pharmacotherapy for otosclerosis includes sodium fluoride. Sudden hearing loss is treated with a 'shotgun' combination of drugs and/or bed rest. There are as yet no drugs which can be used to routinely reduce tinnitus although some medications may help the patient tolerate the problem. Lignocaine (lidocaine) is useful in diagnosing, and very evanescently reducing, tinnitus. Glycerin (glycerol) is useful in diagnosing endolymphatic hydrops and may at

  17. Ketamine as the prototype glutamatergic antidepressant: pharmacodynamic actions, and a systematic review and meta-analysis of efficacy

    Science.gov (United States)

    Caddy, Caroline; Giaroli, Giovanni; White, Thomas P.; Shergill, Sukhwinder S.

    2014-01-01

    The burden of depressive disorders and the frequent inadequacy of their current pharmacological treatments are well established. The anaesthetic and hallucinogenic drug ketamine has provoked much interest over the past decade or so as an extremely rapidly acting antidepressant that does not modify ‘classical’ monoaminergic receptors. Current evidence has shown several ways through which it might exert therapeutic antidepressant actions: blockade of glutamatergic NMDA receptors and relative upregulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtypes may alter cortical connectivity patterns; through intracellular changes in protein expression, including the proteins mammalian target of rapamycin (mTOR) and brain-derived neurotrophic factor (BDNF); and alteration of intracellular signalling cascades. The clinical evidence demonstrates rapid improvements in mood and suicidal thinking in most participants, although study numbers have generally been small and many trials are unblinded and methodologically weak. There is a small body of work to suggest ketamine might also augment electroconvulsive therapy and potentially have a role as a surgical anaesthetic in depressed patients. A major problem is that the effects of ketamine appear temporary, disappearing after days to weeks (although longer benefits have been sustained in some), and attempts to circumvent this through pharmacological augmentation have been disappointing thus far. These exciting data are providing new insights into neurobiological models of depression, and potentially opening up a new class of antidepressants, but there are significant practical and ethical issues about any future mainstream clinical role it might have. PMID:24688759

  18. Action semantics modulate action prediction.

    Science.gov (United States)

    Springer, Anne; Prinz, Wolfgang

    2010-11-01

    Previous studies have demonstrated that action prediction involves an internal action simulation that runs time-locked to the real action. The present study replicates and extends these findings by indicating a real-time simulation process (Graf et al., 2007), which can be differentiated from a similarity-based evaluation of internal action representations. Moreover, results showed that action semantics modulate action prediction accuracy. The semantic effect was specified by the processing of action verbs and concrete nouns (Experiment 1) and, more specifically, by the dynamics described by action verbs (Experiment 2) and the speed described by the verbs (e.g., "to catch" vs. "to grasp" vs. "to stretch"; Experiment 3). These results propose a linkage between action simulation and action semantics as two yet unrelated domains, a view that coincides with a recent notion of a close link between motor processes and the understanding of action language.

  19. There or not there? A multidisciplinary review and research agenda on the impact of transparent barriers on human perception, action, and social behavior

    Directory of Open Access Journals (Sweden)

    Gesine eMarquardt

    2015-09-01

    Full Text Available Through advances in production and treatment technologies, transparent glass has become an increasingly versatile material and a global hallmark of modern architecture. In the shape of invisible barriers, it defines spaces while simultaneously shaping their lighting, noise, and climate conditions. Despite these unique architectural qualities, little is known regarding the human experience with glass barriers. Is a material that has been described as being simultaneously there and not there from an architectural perspective, actually there and/or not there from perceptual, behavioral, and social points of view? In this article, we review systematic observations and experimental studies that explore the impact of transparent barriers on human cognition and action. In doing so, the importance of empirical and multidisciplinary approaches to inform the use of glass in contemporary architecture is highlighted and key questions for future inquiry are identified.

  20. Mathematical models of radiation action on living cells: From the target theory to the modern approaches. A historical and critical review.

    Science.gov (United States)

    Bodgi, Larry; Canet, Aurélien; Pujo-Menjouet, Laurent; Lesne, Annick; Victor, Jean-Marc; Foray, Nicolas

    2016-04-07

    Cell survival is conventionally defined as the capability of irradiated cells to produce colonies. It is quantified by the clonogenic assays that consist in determining the number of colonies resulting from a known number of irradiated cells. Several mathematical models were proposed to describe the survival curves, notably from the target theory. The Linear-Quadratic (LQ) model, which is to date the most frequently used model in radiobiology and radiotherapy, dominates all the other models by its robustness and simplicity. Its usefulness is particularly important because the ratio of the values of the adjustable parameters, α and β, on which it is based, predicts the occurrence of post-irradiation tissue reactions. However, the biological interpretation of these parameters is still unknown. Throughout this review, we revisit and discuss historically, mathematically and biologically, the different models of the radiation action by providing clues for resolving the enigma of the LQ model. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. There or not there? A multidisciplinary review and research agenda on the impact of transparent barriers on human perception, action, and social behavior.

    Science.gov (United States)

    Marquardt, Gesine; Cross, Emily S; de Sousa, Alexandra A; Edelstein, Eve; Farnè, Alessandro; Leszczynski, Marcin; Patterson, Miles; Quadflieg, Susanne

    2015-01-01

    Through advances in production and treatment technologies, transparent glass has become an increasingly versatile material and a global hallmark of modern architecture. In the shape of invisible barriers, it defines spaces while simultaneously shaping their lighting, noise, and climate conditions. Despite these unique architectural qualities, little is known regarding the human experience with glass barriers. Is a material that has been described as being simultaneously there and not there from an architectural perspective, actually there and/or not there from perceptual, behavioral, and social points of view? In this article, we review systematic observations and experimental studies that explore the impact of transparent barriers on human cognition and action. In doing so, the importance of empirical and multidisciplinary approaches to inform the use of glass in contemporary architecture is highlighted and key questions for future inquiry are identified.

  2. The predictive capacity of the theory of reasoned action and the theory of planned behavior in exercise research: an integrated literature review.

    Science.gov (United States)

    Blue, C L

    1995-04-01

    Although the association between habitual exercise and health benefits has been well documented, physical activity levels in the United States are lower than is necessary to reach the nation's health potential. Beliefs that people hold can be a motivating factor in engaging in exercise. A critical review of the literature was conducted to assess the efficacy of using the Theory of Reasoned Action and the Theory of Planned Behavior with respect to exercise. Evidence for the predictive utility of the theories was found. The Theory of Planned Behavior is a more promising framework for the study of exercise because it includes beliefs about control of factors that would facilitate or inhibit carrying out exercise. Strategies for use of the theories in planning exercise programs are provided and suggestions for future research discussed.

  3. Completed EO 12866 Regulatory Reviews by Calendar Year

    Data.gov (United States)

    Executive Office of the President — Annual data set of draft rules reviewed by OMB under Executive Orders 12291 and 12866. The data provide information by agency, length of review in days, and economic...

  4. Accuracy of professional sports drafts in predicting career potential.

    Science.gov (United States)

    Koz, D; Fraser-Thomas, J; Baker, J

    2012-08-01

    The forecasting of talented players is a crucial aspect of building a successful sports franchise and professional sports invest significant resources in making player choices in sport drafts. The current study examined the relationship between career performance (i.e. games played) and draft round for the National Football League, National Hockey League, National Basketball League, and Major League Baseball for players drafted from 1980 to 1989 (n = 4874) against the assumption of a linear relationship between performance and draft round (i.e. that players with the most potential will be selected before players of lower potential). A two-step analysis revealed significant differences in games played across draft rounds (step 1) and a significant negative relationship between draft round and games played (step 2); however, the amount of variance accounted for was relatively low (less than 17%). Results highlight the challenges of accurately evaluating amateur talent.

  5. The Anti-Inflammatory and Antibacterial Action of Nanocrystalline Silver and Manuka Honey on the Molecular Alternation of Diabetic Foot Ulcer: A Comprehensive Literature Review.

    Science.gov (United States)

    Tsang, Ka-Kit; Kwong, Enid Wai-Yung; Woo, Kevin Y; To, Tony Shing-Shun; Chung, Joanne Wai-Yee; Wong, Thomas Kwok-Shing

    2015-01-01

    Honey and silver have been used since ancient times for treating wounds. Their widespread clinical application has attracted attention in light of the increasing prevalence of antibiotic-resistant bacteria. While there have been a number of studies exploring the anti-inflammatory and antibacterial effects of manuka honey and nanocrystalline silver, their advantages and limitations with regard to the treatment of chronic wounds remain a subject of debate. The aim of this paper is to examine the evidence on the use of nanocrystalline silver and manuka honey for treating diabetic foot ulcers through a critical and comprehensive review of in vitro studies, animal studies, and in vivo studies. The findings from the in vitro and animal studies suggest that both agents have effective antibacterial actions. Their anti-inflammatory action and related impact on wound healing are unclear. Besides, there is no evidence to suggest that any topical agent is more effective for use in treating diabetic foot ulcer. Overall, high-quality, clinical human studies supported by findings from the molecular science on the use of manuka honey or nanocrystalline silver are lacking. There is a need for rigorously designed human clinical studies on the subject to fill this knowledge gap and guide clinical practice.

  6. Systematic review on the rapidity of the onset of action of topical treatments in the therapy of mild-to-moderate acne vulgaris.

    Science.gov (United States)

    Jacobs, A; Starke, G; Rosumeck, S; Nast, A

    2014-03-01

    The time until a patient achieves a relevant improvement during the treatment of a skin disease is important for selecting a therapy, but has been largely neglected in reviews and guidelines. The aim of this systematic review was to determine the time until the onset of action (TOA) of topical acne treatments. The primary outcome was the TOA defined as the time until a 25% reduction in the mean number of inflammatory lesions had been achieved. A systematic literature search in Medline and Embase was carried out. Clinical trials that evaluated head-to-head comparisons of treatments in patients suffering from mild-to-moderate papulopustular acne were included. Abstract and full-text screening and data extraction were done independently by two investigators. With respect to inflammatory lesions, different concentrations of benzoyl peroxide (BPO) or adapalene did not seem to influence the TOA. BPO seemed to act more quickly than isotretinoin and tretinoin. Adapalene showed a shorter TOA than isotretinoin. Conflicting results were seen when comparing adapalene with tretinoin, with a tendency for adapalene to be faster. Clindamycin/BPO seemed to act more quickly than adapalene. Inconsistent results were seen for the comparison of clindamycin/BPO and BPO alone with a slight indication of a shorter TOA for clindamycin/BPO. Adapalene/BPO and clindamycin/BPO showed comparable TOA. When interpreting the data, the different study designs and the limited study quality need to be taken into account. Further research is needed to identify treatments that offer an early onset of action and possibly help to optimize patients' adherence. TOA should be considered as an additional outcome in acne trials.

  7. Complementary and alternative medicine in the treatment of refugees and survivors of torture: a review and proposal for action.

    Science.gov (United States)

    Longacre, McKenna; Silver-Highfield, Ellen; Lama, Puja; Grodin, Michael

    2012-01-01

    Survivors of torture and refugee trauma often have increased needs for mental and physical healthcare. This is due in part to the complex sequelae of trauma, including chronic pain, major depressive disorder, posttraumatic stress disorder (PTSD) and somatization. This article reviews the scientific medical literature for the efficacy and feasibility of some complementary and alternative medicine (CAM) modalities including meditation, Ayurveda, pranayama/yogic breathing, massage/body-work, dance/movement, spirituality, yoga, music, Traditional Chinese Medicine and acupuncture, qigong, t'ai chi, chiropractic, homeopathy, aromatherapy and Reiki specifically with respect to survivors of torture and refugee trauma. We report that preliminary research suggests that the certain CAM modalities may prove effective as part of an integrated treatment plan for survivors of torture and refugee trauma. Further research is warranted.

  8. 75 FR 27579 - Bison Brucellosis Remote Vaccination, Draft Environmental Impact Statement, Yellowstone National...

    Science.gov (United States)

    2010-05-17

    ... National Park Service Bison Brucellosis Remote Vaccination, Draft Environmental Impact Statement... Availability of the Draft Environmental Impact Statement for a Bison Brucellosis Remote Vaccination Program... Vaccination Draft Environmental Impact Statement (EIS) for Yellowstone National Park. This planning...

  9. 78 FR 54906 - Draft Supplemental Environmental Impact Report/Environmental Impact Statement for a Proposed...

    Science.gov (United States)

    2013-09-06

    ... Fish and Wildlife Service Draft Supplemental Environmental Impact Report/Environmental Impact Statement... Coachella Valley Conservation Commission (CVCC), has prepared a joint draft Supplemental Environmental Impact Report/Environmental Impact Statement (draft Supplemental EIR/EIS) under the...

  10. 75 FR 52355 - Draft National Conversation on Public Health and Chemical Exposures Work Group Reports...

    Science.gov (United States)

    2010-08-25

    ... Prevention Draft National Conversation on Public Health and Chemical Exposures Work Group Reports... exposures. This notice announces the availability of draft National Conversation work group reports for... National Conversation Leadership Council and facilitating the work group process. DATES: Draft work...

  11. 75 FR 63189 - Draft Guidance for Industry on Investigational New Drug Applications-Determining Whether Human...

    Science.gov (United States)

    2010-10-14

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Investigational New Drug... Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled... draft guidance for industry entitled ``Investigational New Drug Applications (INDs)--Determining...

  12. 77 FR 69632 - Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Availability

    Science.gov (United States)

    2012-11-20

    ... entitled ``Electronic Source Data in Clinical Investigations.'' This document revises and updates the draft... in FDA- regulated clinical investigations. The revised draft guidance promotes capturing source data... draft guidance for industry entitled ``Electronic Source Data in Clinical Investigations.''...

  13. DSP4, a selective neurotoxin for the locus coeruleus noradrenergic system. A review of its mode of action.

    Science.gov (United States)

    Ross, Svante B; Stenfors, Carina

    2015-01-01

    DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride) is a selective neurotoxin for the locus coeruleus noradrenergic system in the rodent and bird brain. It readily passes the blood-brain barrier and cyclizes to a reactive aziridinium derivative that is accumulated into the noradrenergic nerve terminals via the noradrenaline transporter. DSP4 is also an irreversible inhibitor of this transporter. Within the nerve terminals the aziridinium derivative reacts with unknown vital cellular components, destroying the terminals. At the dose 50 mg/kg i.p. this is characterized by a rapid and long-lasting loss of noradrenaline and a slower decrease in the dopamine-β-hydroxylase enzyme activity and immunoreactivity in the regions innervated from locus coeruleus. The tissue level of noradrenaline is reduced to 10-30% of the normal value. The extraneuronal concentration is, on the other hand, increased due to inflow from non-lesioned regions. Like the peripheral sympathetic nerves the non-locus coeruleus noradrenergic systems in the rodent brain is resistant to the neurotoxic action of DSP4. Serotoninergic and dopaminergic nerves are only slightly or not at all affected by DSP4. The neurotoxic effect is counteracted by pretreatment with noradrenaline uptake inhibitors (e.g., desipramine). MAO-B inhibitors of the N-propargylamine type (e.g., selegiline) also counteract the DSP4-induced neurotoxicity with another, yet unknown mechanism. Because of its selectivity for the locus coeruleus system DSP4 is a useful tool in studies of the functional role of this noradrenergic system in the brain.

  14. Constructing racial hierarchies of skill – Experiencing affirmative action in a South African organisation: A qualitative review

    Directory of Open Access Journals (Sweden)

    Shanya Reuben

    2014-05-01

    Full Text Available Orientation: Apartheid in South Africa constructed racial, economic, social and political segregation, the consequences of which are still experienced today. Government has made concerted efforts to ‘deracialise’ South Africa, most notably through affirmative action (AA measures. Research purpose: This study aimed to explore employees’ social constructions of AA in a South African organisation. Motivation for the study: Research in this field focuses mostly on attitudinal perspectives of AA with an emphasis on traditional approaches. Subjective, contextualised approaches to AA have received little attention. Thus, this study aimed to critically engage with the embodied nature of prejudice, particularly in reference to how we understand and experience AA. Research approach, design and method: This study aimed to explore AA from a social constructionist orientation, using semi-structured interviews. More specifically, this study used Potter and Wetherell’s discursive psychology. Main findings: The findings illustrate how participants engage in discursive devices that continue to rationalise a racial order of competence. Ultimately, AA is a controversial subject that traverses many segments of life for all South Africans. Practical/managerial implications: The findings contribute to the discipline of industrial psychology, particularly with regard to policies around preferential treatment, and can add value to the ways in which organisational policy documents are conceptualised. The findings also suggest the importance of developing an inclusive, non-discriminatory organisational culture. Contribution/value-add: This approach adds to the existing body of knowledge around the embodied nature of prejudice. The study’s methodology highlights the value of studying context in meaning-making and implied inferences that underlie talk.

  15. Constructing racial hierarchies of skill – Experiencing affirmative action in a South African organisation: A qualitative review

    Directory of Open Access Journals (Sweden)

    Shanya Reuben

    2014-02-01

    Full Text Available Orientation: Apartheid in South Africa constructed racial, economic, social and political segregation, the consequences of which are still experienced today. Government has made concerted efforts to ‘deracialise’ South Africa, most notably through affirmative action (AA measures.Research purpose: This study aimed to explore employees’ social constructions of AA in a South African organisation.Motivation for the study: Research in this field focuses mostly on attitudinal perspectives of AA with an emphasis on traditional approaches. Subjective, contextualised approaches to AA have received little attention. Thus, this study aimed to critically engage with the embodied nature of prejudice, particularly in reference to how we understand and experience AA.Research approach, design and method: This study aimed to explore AA from a social constructionist orientation, using semi-structured interviews. More specifically, this study used Potter and Wetherell’s discursive psychology.Main findings: The findings illustrate how participants engage in discursive devices that continue to rationalise a racial order of competence. Ultimately, AA is a controversial subject that traverses many segments of life for all South Africans.Practical/managerial implications: The findings contribute to the discipline of industrial psychology, particularly with regard to policies around preferential treatment, and can add value to the ways in which organisational policy documents are conceptualised. The findings also suggest the importance of developing an inclusive, non-discriminatory organisational culture.Contribution/value-add: This approach adds to the existing body of knowledge around the embodied nature of prejudice. The study’s methodology highlights the value of studying context in meaning-making and implied inferences that underlie talk.

  16. Draft Genome Sequence of Rubrivivax gelatinosus CBS

    Energy Technology Data Exchange (ETDEWEB)

    Hu, P. S.; Lang, J.; Wawrousek, K.; Yu, J. P.; Maness, P. C.; Chen, J.

    2012-06-01

    Rubrivivax gelatinosus CBS, a purple nonsulfur photosynthetic bacterium, can grow photosynthetically using CO and N{sub 2} as the sole carbon and nitrogen nutrients, respectively. R. gelatinosus CBS is of particular interest due to its ability to metabolize CO and yield H{sub 2}. We present the 5-Mb draft genome sequence of R. gelatinosus CBS with the goal of providing genetic insight into the metabolic properties of this bacterium.

  17. Draft genome sequence of the Tibetan antelope

    OpenAIRE

    Ge, Ri-Li; Cai, Qingle; Shen, Yong-Yi; San, A.; Ma, Lan; Zhang, Yong; Yi, Xin; Chen, Yan; Yang, Lingfeng; Huang, Ying; He, Rongjun; Hui, Yuanyuan; Hao, Meirong; Li, Yue; Wang, Bo

    2013-01-01

    The Tibetan antelope (Pantholops hodgsonii) is endemic to the extremely inhospitable high-altitude environment of the Qinghai-Tibetan Plateau, a region that has a low partial pressure of oxygen and high ultraviolet radiation. Here we generate a draft genome of this artiodactyl and use it to detect the potential genetic bases of highland adaptation. Compared with other plain-dwelling mammals, the genome of the Tibetan antelope shows signals of adaptive evolution and gene-family expansion in ge...

  18. Draft scientific concept of the research project

    Directory of Open Access Journals (Sweden)

    Bazić Miljojko

    2015-01-01

    Full Text Available Every scientific research involves the systematic study of phenomena and processes that occur in nature and society. Such a systematic study is not possible without the use of objective instruments for collecting, processing and analyzing data and without the application of scientific methods for drawing conclusions, propriety and legality of the researching object properties. That is why all systematic scientific studies require advance planning and design, and that in one scientific, operational and planning document, called the research project is devised a way of acquiring scientific knowledge, which will represent a logical, structured unit, rational and purposeful, mutually compatible and functionally related attitudes, judgments and conclusions of the research subject. The general methodology of scientific research has defined the scientific standards, rules and procedures by which a scientific research project is created. The project of scientific research has a standard structure element of the project which consists of: a draft scientific concept; b research plans; iv research instruments, including a plan of arrangement and data processing. Since numerous difficulties encountered by young researchers in establishing draft scientific ideas in theirs Master's and Doctoral Theses in the last edition of the Megatrend journal, we have offered to scientific and professional public the first three elements of the scientific concept structure draft of the research project: formulation of the research problem, determination of research subject and the formulation of scientific and social research objectives. In this edition of the Megatrend journal, according to the strict requirements of the general methodology of science and special methodology of science, scientific and professional community, we present the following three elements of the draft of the scientific concept of research: a hypothetical framework of the research, the method of

  19. Draft scientific concept of the research project

    Directory of Open Access Journals (Sweden)

    Bazić Miljojko

    2015-01-01

    Full Text Available Every scientific research is the systematic study of subjects, phenomena and processes that occur in nature and society, based on the use of scientific instruments for collecting, processing and analyzing data as well as the application of scientific methods for drawing conclusions about the properties of researching objects. precisely because each study needs to have systematic research character, it is necessary to design and plan in advance. The research project is a fundamental scientific and operational- planning document that represents a pre-designed model of acquiring scientific knowledge, structured as a target, rational purposeful system of mutually compatible and functionally related knowledge, attitudes, judgments and conclusions about the research subject. Because there are a number of different scientific disciplines and within them an even greater number of different types of research, general methodology of scientific research, as well as universal science, has defined certain standards and rules under which compiles every scientific project. Regardless of the scientific field, research project has a standard global structure consisting of: a draft scientific ideas; b research plans; c research instruments, including plans for processing data. Given the importance of the conceptualization of the research project, as a pre-designed model of acquisition of scientific knowledge and the numerous difficulties encountered by young researchers in establishing a draft of the scientific concept of their master and doctoral theses, the authors of this article have decided to offer an overall structure of the scientific draft of the research project, according to the requirements of modern general methodology and special sciences methodologies to the wider scientific community, in the next two editions of the Megatrend university journal. Due to the volume of subject matter, this paper refers only to the first three elements of the

  20. 75 FR 17989 - Bureau of Oceans and International Environmental Scientific Affairs; Climate Action Report

    Science.gov (United States)

    2010-04-08

    ... of Oceans and International Environmental Scientific Affairs; Climate Action Report AGENCY... submitted the first U.S. Climate Action Report (CAR) to the UNFCCC Secretariat in 1994, and subsequent reports in 1997, 2002, and 2006. The U.S. Government has prepared an initial draft of the fifth...