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Sample records for actinium 229

  1. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  2. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  3. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  4. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Science.gov (United States)

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development.

  5. Relativistic small-core pseudopotentials for actinium, thorium, and protactinium.

    Science.gov (United States)

    Weigand, Anna; Cao, Xiaoyan; Hangele, Tim; Dolg, Michael

    2014-04-03

    Small-core pseudopotentials for actinium, thorium, and protactinium have been energy-adjusted to multiconfiguration Dirac-Hartree-Fock reference data based on the Dirac-Coulomb-Breit Hamiltonian and the Fermi nucleus model. Corresponding optimized valence basis sets of polarized valence quadruple-ζ quality are presented. Atomic test calculations for the first four ionization potentials show satisfactory results at both the Hartree-Fock and the multireference averaged coupled-pair functional level. Highly correlated Fock-space coupled cluster calculations demonstrate that the new pseudopotentials yield ionization potentials, which are in excellent agreement with corresponding all-electron results and experimental data. The pseudopotentials and basis sets supplement a similar set previously published for uranium.

  6. Effects of spin-orbit coupling on actinium under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Rubio-Ponce, A.; Rivera, J. [Departamento de Ciencias Basicas, Universidad Autonoma Metropolitana-Azcapotzalco, Mexico (Mexico); Olguin, D. [Departamento de Fi sica, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico (Mexico)

    2015-04-15

    Actinium (Ac) is a radioactive metal and the first element of the actinide series. At ambient conditions Ac crystallizes in the fcc lattice, however, up to date its phase diagram is unknown. In the present work, we have studied the structural and electronic properties of Ac under hydrostatic pressure assuming the fcc structure as well as three hypothetical structures, namely the hcp, bcc, and sc, and for pressures up to 100 GPa. From our calculations, we found only one structural transition allowed, from the fcc to hcp, our calculated pressure was 39.85 GPa. The calculations were performed by means of the full potential linearized augmented plane wave (FLAPW) method and the generalized gradient approximation (GGA) for the exchange-correlation energy, where we have included in our study the spin-orbit coupling which is important for heavy elements. The total energy results were fitted to the third order Birch-Murnaghan's equation of state. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  7. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  8. Report for General Research September 18 to December 11, 1950 (Actinium Volume)

    Energy Technology Data Exchange (ETDEWEB)

    Haring, M.M.

    1951-01-15

    The purpose of the research work presented in this volume is to develop a process for the separation and purification of actinium-227 produced by neutron bombardment of radium-226 and to develop methods by which uniform films of actinium metal may be deposited on metallic surfaces. The design work on the cave structure and mechanical equipment used in the actinium separation is proceeding on schedule. As the mechanical design phase is nearing completion the emphasis is being directed toward processing equipment. The process as well as the mechanical equipment has been adapted from the research work of F. T. Hagemann and the Remote Control Group at Argonne National Laboratory. Consequently, one of the first objectives is to become familiary with the chemistry of the process and the operation of the mechanical equipment. Cold runs have been made on the T.T.A. benzene extraction using lanthanum and barium in place of actinium and radium. No difficulty with the operation was observed. The formation of precipitates was one of the difficulties encountered with the process as the precipitates carry radium. It has been found that metals such as nickel cause these precipitates to form and should, therefore, be avoided in the construction of equipment. it was also found that a T.T.A. solution exposed to 0.5 curie of polonium over a period of days develops a precipitate. Some new mechanical features hav eshown promise. The use of copper-coated glassware which will hold together even though the glass is cracked has made it possible to replace custom-built heaters with standard heating mantles. A new graphite, silicone grease mixture appears to hold up in stopcocks handling benzene and, as a result, may eliminate the necessary of entering the cave for regreasing. Tests on the preparation of dense concrete have given results which meet the shielding requirements for the cave. A strippable paint and tape combination has been studied and specified to provide for decontamination of

  9. 22 CFR 229.310 - Recruitment.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Recruitment. 229.310 Section 229.310 Foreign... and Recruitment Prohibited § 229.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 229.300 through 229.310 apply shall not discriminate on the basis of sex in the recruitment and...

  10. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  11. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  12. Nuclear structure of $^{229}$Th

    CERN Document Server

    Ruchowska, E; Zylicz, J; Mach, H; Kvasil, J; Algora, A; Amzal, N; Bäck, T; García-Borge, M J; Boutami, R; Butler, P A; Cederkäll, J; Cederwall, Bo; Fogelberg, B; Fraile-Prieto, L M; Fynbo, H O U; Hagebø, E; Hoff, P; Gausemel, H; Jungclaus, A; Kaczarowski, R; Kérek, A; Kurcewicz, W; Lagergren, K; Nacher, E; Rubio, B; Syntfeld, A; Tengblad, O; Wasilewski, A A

    2006-01-01

    Lifetimes of excited states in $^{229}$Th, populated in the $\\beta$-decay of $^{229}$Ac, have been measured using the advanced time-delayed $\\beta\\gamma\\gamma$(t)-method. Half-lives of 14 states have been determined including 11 of them for the first time. Twenty-seven new $\\gamma$-lines have been introduced into the $\\beta$-decay scheme of $^{229}$Ac based on results of $\\gamma\\gamma$-coincidence measurements. Reduced transition probabilities have been determined for more than 70 $\\gamma$-transitions in $^{229}$Th. Average ∣D$_{0}$∣ values of 0.029(1), 0.077(3) and 0.024(5) $e$ fm have been deduced for the lowest K$^{\\pi}$=1/2$^{\\pm}$ , 3/2$^{\\pm}$ and 5/2$^{\\pm}$ parity partner bands, respectively. Excited states in $^{229}$Th and experimental transition rates have been interpreted within the quasiparticle-plus-phonon model. The half-life of the 3.5 eV , 3/2$^{+}$ isomeric state is predicted to be about 10 h. Potential energy surfaces on the ($\\beta_{2}\\,,\\,\\beta_{3}$) plane for the lowest single quasi...

  13. 22 CFR 229.510 - Recruitment.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Recruitment. 229.510 Section 229.510 Foreign... in Education Programs or Activities Prohibited § 229.510 Recruitment. (a) Nondiscriminatory recruitment and hiring. A recipient shall not discriminate on the basis of sex in the recruitment and hiring...

  14. 30 CFR 229.4 - Authority.

    Science.gov (United States)

    2010-07-01

    ... STATES General Provisions § 229.4 Authority. The Secretary of the DOI is authorized under provisons of 30 U.S.C. 1735 to delegate authority to States to conduct audits and related investigations with... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Authority. 229.4 Section 229.4 Mineral...

  15. 49 CFR 229.61 - Draft system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Draft system. 229.61 Section 229.61 Transportation... TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Draft System § 229.61 Draft system. (a) A.... Suspension System...

  16. 22 CFR 229.540 - Advertising.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Advertising. 229.540 Section 229.540 Foreign... in Education Programs or Activities Prohibited § 229.540 Advertising. A recipient shall not in any advertising related to employment indicate preference, limitation, specification, or discrimination based...

  17. 49 CFR 229.117 - Speed indicators.

    Science.gov (United States)

    2010-10-01

    ... normal position under all light conditions. (b) Each speed indicator required shall be tested as soon as... 49 Transportation 4 2010-10-01 2010-10-01 false Speed indicators. 229.117 Section 229.117... § 229.117 Speed indicators. (a) After December 31, 1980, each locomotive used as a...

  18. 12 CFR 229.57 - Consumer awareness.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Consumer awareness. 229.57 Section 229.57 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Substitute Checks § 229.57 Consumer awareness...

  19. 22 CFR 229.505 - Employment criteria.

    Science.gov (United States)

    2010-04-01

    ... Employment in Education Programs or Activities Prohibited § 229.505 Employment criteria. A recipient shall... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Employment criteria. 229.505 Section 229.505 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF SEX IN...

  20. 20 CFR 229.45 - Employee benefit.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Employee benefit. 229.45 Section 229.45 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Computation of the Overall Minimum Rate § 229.45 Employee benefit. The...

  1. 22 CFR 229.515 - Compensation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Compensation. 229.515 Section 229.515 Foreign... in Education Programs or Activities Prohibited § 229.515 Compensation. A recipient shall not make or... compensation; (b) Results in the payment of wages to employees of one sex at a rate less than that paid...

  2. 33 CFR 136.229 - Compensation allowable.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Compensation allowable. 136.229 Section 136.229 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.229...

  3. Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

    Science.gov (United States)

    Radchenko, V; Engle, J W; Wilson, J J; Maassen, J R; Nortier, F M; Taylor, W A; Birnbaum, E R; Hudston, L A; John, K D; Fassbender, M E

    2015-02-06

    Actinium-225 (t1/2=9.92d) is an α-emitting radionuclide with nuclear properties well-suited for use in targeted alpha therapy (TAT), a powerful treatment method for malignant tumors. Actinium-225 can also be utilized as a generator for (213)Bi (t1/2 45.6 min), which is another valuable candidate for TAT. Actinium-225 can be produced via proton irradiation of thorium metal; however, long-lived (227)Ac (t1/2=21.8a, 99% β(-), 1% α) is co-produced during this process and will impact the quality of the final product. Thus, accurate assays are needed to determine the (225)Ac/(227)Ac ratio, which is dependent on beam energy, irradiation time and target design. Accurate actinium assays, in turn, require efficient separation of actinium isotopes from both the Th matrix and highly radioactive activation by-products, especially radiolanthanides formed from proton-induced fission. In this study, we introduce a novel, selective chromatographic technique for the recovery and purification of actinium isotopes from irradiated Th matrices. A two-step sequence of cation exchange and extraction chromatography was implemented. Radiolanthanides were quantitatively removed from Ac, and no non-Ac radionuclidic impurities were detected in the final Ac fraction. An (225)Ac spike added prior to separation was recovered at ≥ 98%, and Ac decontamination from Th was found to be ≥ 10(6). The purified actinium fraction allowed for highly accurate (227)Ac determination at analytical scales, i.e., at (227)Ac activities of 1-100 kBq (27 nCi to 2.7 μCi). Copyright © 2014 Elsevier B.V. All rights reserved.

  4. 229

    African Journals Online (AJOL)

    2001-05-01

    May 1, 2001 ... Background: Cancer has emerged as one of the common causes of morbidity and mortality ... breast comprising 24 % of the total cases, followed by endometrium .... resection followed by radiotherapy and axillary dissection.

  5. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  6. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Energy Technology Data Exchange (ETDEWEB)

    Raeder, S., E-mail: s.raeder@gsi.de [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Bastin, B. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Block, M. [Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Institut für Kernchemie, Johannes Gutenberg Universität, 55128 Mainz (Germany); Creemers, P. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Ferrer, R. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fléchard, X. [LPC Caen, ENSICAEN, Université de Caen, CNRS/IN2P3, Caen (France); Franchoo, S. [Institute de Physique Nucléaire (IPN) d’Orsay, 91406 Orsay, Cedex (France); Ghys, L. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); SCK-CEN, Belgian Nuclear Research Center, Boeretang 200, 2400 Mol (Belgium); Gaffney, L.P.; Granados, C. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Heinke, R. [Institut für Physik, Johannes Gutenberg Universität, 55128 Mainz (Germany); Hijazi, L. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); and others

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  7. Standardisation of a {sup 229}Th solution

    Energy Technology Data Exchange (ETDEWEB)

    Crespo, M.T. [CIEMAT, Laboratorio de Metrologia de Radiaciones Ionizantes (LMRI), Avda. Complutense 22, 28040 Madrid (Spain)]. E-mail: teresa.crespo@ciemat.es

    2007-08-15

    The use of {sup 229}Th as tracer has become generalised for determination of naturally occurring alpha-emitting thorium isotopes. This paper describes two procedures that allow standardising {sup 229}Th solutions of the order of Bq/g without the need of radiochemical separation of its daughters.

  8. Dicty_cDB: SSG229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSG229 (Link to dictyBase) - G20964 DDB0214944 Contig-U04201-1 SSG...229E (Link to Original site) SSG229F 664 SSG229Z 767 SSG229P 1431 SSG229E 802 Show SSG229 Library SS (Li...nk to library) Clone ID SSG229 (Link to dictyBase) Atlas ID - NBRP ID G20964 dictyBase ID DDB0214944 Link to... Contig Contig-U04201-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSG2-B/SSG...229Q.Seq.d/ Representative seq. ID SSG229E (Link to Original site) Representative DNA sequence >SSG229 (SSG

  9. 12 CFR 229.38 - Liability.

    Science.gov (United States)

    2010-01-01

    ... circumstances require. (f) Exclusion. Section 229.21 of this part and section 611 (a), (b), and (c) of the EFA... under this subpart may be brought in any United States district court, or in any other court...

  10. 49 CFR 229.55 - Piston travel.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Brake System § 229.55 Piston travel. (a) Brake cylinder piston travel shall be sufficient to provide brake shoe clearance...

  11. Dicty_cDB: CFK229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CF (Link to library) CFK229 (Link to dictyBase) - - - Contig-U15579-1 CFK229P (Link... to Original site) CFK229F 168 CFK229Z 401 CFK229P 549 - - Show CFK229 Library CF (Link to library) Clone ID CFK229 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U15579-1 Original site URL http://dict...e 2001.11.22 Translated Amino Acid sequence yehlinktq*ksilfiyl**hymni*klenif*KLENIIKKRNKLIFNYKKK--- ---DXICT...ni*klenif*KLENIIKKRNKLIFNYKKK--- ---DXICTXXMXNV*xnlvk*vlxvxqxqxivmimihvxxixviqx*v

  12. 22 CFR 229.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 229.105 Definitions. As used in... following, when authorized or extended under a law administered by the Federal agency that awards such... admission. Title IX means Title IX of the Education Amendments of 1972, Public Law 92-318, 86 Stat. 235, 373...

  13. 49 CFR 229.29 - Biennial tests.

    Science.gov (United States)

    2010-10-01

    ..., and tested as prescribed in § 229.27(a), all valves, valve portions, MU locomotive brake cylinders and electric-pneumatic master controllers in the air brake system (including related dirt collectors and... of the air brake system that are cleaned, repaired, and tested shall be kept in the carrier's...

  14. 17 CFR 229.902 - (Item 902) Individual partnership supplements.

    Science.gov (United States)

    2010-04-01

    ... partnership supplements. 229.902 Section 229.902 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Roll-Up Transactions § 229.902 (Item 902) Individual partnership supplements. (a) If two or more entities are proposed to be included...

  15. 17 CFR 229.801 - Securities Act industry guides.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Securities Act industry guides. 229.801 Section 229.801 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD... AND CONSERVATION ACT OF 1975-REGULATION S-K List of Industry Guides § 229.801 Securities Act industry...

  16. 49 CFR 229.97 - Grounding fuel tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Grounding fuel tanks. 229.97 Section 229.97 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 229.97 Grounding fuel tanks. Fuel tanks and related piping shall be electrically grounded....

  17. 7 CFR 58.229 - Filler and packaging equipment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Filler and packaging equipment. 58.229 Section 58.229....229 Filler and packaging equipment. All filling and packaging equipment shall be of sanitary... equipment should comply with the 3-A Sanitary Standards for equipment for Packaging Dry Milk and Dry...

  18. 48 CFR 229.101 - Resolving tax problems.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Resolving tax problems. 229.101 Section 229.101 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES General 229.101 Resolving tax problems....

  19. 49 CFR 229.213 - Locomotive manufacturing information.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Locomotive manufacturing information. 229.213 Section 229.213 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Design Requirements § 229.213 Locomotive manufacturing information. (a) Each railroad operating...

  20. 17 CFR 229.802 - Exchange Act industry guides.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Exchange Act industry guides. 229.802 Section 229.802 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD... AND CONSERVATION ACT OF 1975-REGULATION S-K List of Industry Guides § 229.802 Exchange Act industry...

  1. 17 CFR 229.507 - (Item 507) Selling security holders.

    Science.gov (United States)

    2010-04-01

    ... holders. 229.507 Section 229.507 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Provisions § 229.507 (Item 507) Selling security holders. If any of the securities to be registered are to be offered for the account of security holders, name each such security holder, indicate the nature of...

  2. 40 CFR 229.1 - Burial at sea.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Burial at sea. 229.1 Section 229.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING GENERAL PERMITS § 229.1 Burial at sea. (a) All persons subject to title I of the Act are hereby granted a general permit...

  3. 12 CFR 229.37 - Variation by agreement.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Variation by agreement. 229.37 Section 229.37 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Collection of Checks § 229.37 Variation...

  4. 12 CFR 229.60 - Variation by agreement.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Variation by agreement. 229.60 Section 229.60 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Substitute Checks § 229.60 Variation...

  5. 49 CFR 229.121 - Locomotive cab noise.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Locomotive cab noise. 229.121 Section 229.121... § 229.121 Locomotive cab noise. (a) Performance standards for locomotives. (1) When tested for static noise in accordance with paragraph (a)(3) of this section, all locomotives of each design or model...

  6. 49 CFR 229.79 - Third rail shoes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Third rail shoes. 229.79 Section 229.79..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Electrical System § 229.79 Third rail shoes. When locomotives are equipped with both third rail and overhead...

  7. 49 CFR 229.43 - Exhaust and battery gases.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Exhaust and battery gases. 229.43 Section 229.43... § 229.43 Exhaust and battery gases. (a) Products of combustion shall be released entirely outside the... conditions. (b) Battery containers shall be vented and batteries kept from gassing excessively. ...

  8. 17 CFR 229.1117 - (Item 1117) Legal proceedings.

    Science.gov (United States)

    2010-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1117) Legal proceedings. 229.1117 Section 229.1117 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION...

  9. 17 CFR 229.1110 - (Item 1110) Originators.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1110 (Item... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1110) Originators. 229.1110 Section 229.1110 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD...

  10. 17 CFR 229.1104 - (Item 1104) Sponsors.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1104 (Item... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1104) Sponsors. 229.1104 Section 229.1104 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD...

  11. 48 CFR 252.229-7001 - Tax relief.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Tax relief. 252.229-7001... Clauses 252.229-7001 Tax relief. As prescribed in 229.402-70(a), use the following clause: Tax Relief (JUN... or components intended to be imported in order to ensure that relief from import duties is obtained...

  12. Hyperfine structure in 229gTh3+ as a probe of the 229gTh→ 229mTh nuclear excitation energy.

    Science.gov (United States)

    Beloy, K

    2014-02-14

    We identify a potential means to extract the 229gTh→ 229mTh nuclear excitation energy from precision microwave spectroscopy of the 5F(5/2,7/2) hyperfine manifolds in the ion 229gTh3+. The hyperfine interaction mixes this ground fine structure doublet with states of the nuclear isomer, introducing small but observable shifts to the hyperfine sublevels. We demonstrate how accurate atomic structure calculations may be combined with the measurement of the hyperfine intervals to quantify the effects of this mixing. Further knowledge of the magnetic dipole decay rate of the isomer, as recently reported, allows an indirect determination of the nuclear excitation energy.

  13. 36 CFR 223.229 - Contents of prospectus.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Contents of prospectus. 223.229 Section 223.229 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Special Forest Products Advertisement and Bids §...

  14. 49 CFR 229.91 - Motors and generators.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Motors and generators. 229.91 Section 229.91 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION....91 Motors and generators. A motor or a generator may not have any of the following conditions: (a)...

  15. 49 CFR 229.57 - Foundation brake gear.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Foundation brake gear. 229.57 Section 229.57 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Foundation brake gear. A lever, rod, brake beam, hanger, or pin may not be worn through more than 30...

  16. 50 CFR 229.11 - Confidential fisheries data.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Confidential fisheries data. 229.11 Section 229.11 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS AUTHORIZATION FOR COMMERCIAL FISHERIES UNDER THE...

  17. 50 CFR 229.8 - Publication of List of Fisheries.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Publication of List of Fisheries. 229.8 Section 229.8 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS AUTHORIZATION FOR COMMERCIAL FISHERIES UNDER THE...

  18. 50 CFR 229.5 - Requirements for Category III fisheries.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Requirements for Category III fisheries. 229.5 Section 229.5 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS AUTHORIZATION FOR COMMERCIAL FISHERIES...

  19. 17 CFR 229.101 - (Item 101) Description of business.

    Science.gov (United States)

    2010-04-01

    ... this Item, the registrant should take into account both quantitative and qualitative factors such as... the information in quantitative terms may not appear significant to the registrant's business taken as... business. 229.101 Section 229.101 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION...

  20. 40 CFR 229.2 - Transport of target vessels.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Transport of target vessels. 229.2... PERMITS § 229.2 Transport of target vessels. (a) The U.S. Navy is hereby granted a general permit to... used as a target vessel, its approximate tonnage, and the location and date of sinking. ...

  1. 12 CFR 229.55 - Expedited recredit for banks.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Expedited recredit for banks. 229.55 Section 229.55 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE... Expedited recredit for banks. (a) Circumstances giving rise to a claim. A bank that has an indemnity...

  2. 48 CFR 252.229-7002 - Customs exemptions (Germany).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Customs exemptions... of Provisions And Clauses 252.229-7002 Customs exemptions (Germany). As prescribed in 229.402-70(b), use the following clause: Customs Exemptions (Germany) (JUN 1997) Imported products required for...

  3. 17 CFR 229.302 - (Item 302) Supplementary financial information.

    Science.gov (United States)

    2010-04-01

    ... paragraphs 9-34 of Statement of Financial Accounting Standards (“SFAS”) No. 69, “Disclosures about Oil and... financial information. 229.302 Section 229.302 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Financial Information §...

  4. 17 CFR 229.1010 - (Item 1010) Financial statements.

    Science.gov (United States)

    2010-04-01

    ... share data, statements of cash flows, and comprehensive income required to be included in the company's... statements. 229.1010 Section 229.1010 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION....1010 (Item 1010) Financial statements. (a) Financial information. Furnish the following financial...

  5. 22 CFR 229.545 - Pre-employment inquiries.

    Science.gov (United States)

    2010-04-01

    ... EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 229.545 Pre-employment inquiries. (a... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Pre-employment inquiries. 229.545 Section...

  6. 22 CFR 229.435 - Employment assistance to students.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Employment assistance to students. 229.435... Basis of Sex in Education Programs or Activities Prohibited § 229.435 Employment assistance to students... agency, organization, or person in making employment available to any of its students: (1) Shall...

  7. 48 CFR 252.229-7003 - Tax Exemptions (Italy).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Tax Exemptions (Italy... of Provisions And Clauses 252.229-7003 Tax Exemptions (Italy). As prescribed in 229.402-70(c), use the following clause: Tax Exemptions (Italy) (JAN 2002) (a) The Contractor represents that...

  8. 49 CFR 229.137 - Sanitation, general requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Sanitation, general requirements. 229.137 Section... Cab Equipment § 229.137 Sanitation, general requirements. (a) Sanitation compartment. Except as provided in paragraph (b) of this section, all lead locomotives in use shall be equipped with a...

  9. 49 CFR 229.139 - Sanitation, servicing requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Sanitation, servicing requirements. 229.139... Cab Equipment § 229.139 Sanitation, servicing requirements. (a) The sanitation compartment of each... present that prevents waste from evacuating the bowl. (c) The sanitation compartment of each...

  10. 49 CFR 229.81 - Emergency pole; shoe insulation.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Emergency pole; shoe insulation. 229.81 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Electrical System § 229.81 Emergency pole; shoe insulation. (a) Each locomotive equipped with a pantograph...

  11. 17 CFR 229.1123 - (Item 1123) Servicer compliance statement.

    Science.gov (United States)

    2010-04-01

    ... 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1123) Servicer compliance statement. 229.1123 Section 229.1123 Commodity and Securities Exchanges SECURITIES AND EXCHANGE...

  12. 17 CFR 229.1120 - (Item 1120) Ratings.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1120 (Item... rating monitored while the asset-backed securities are outstanding. ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1120) Ratings. 229.1120...

  13. Dicty_cDB: VHF229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Sequences producing significant alignments: (bits) Value VHF229 (VHF229Q) /CSM/VH/VHF2-B/VHF229Q.Seq.d/ 68 ...v41i08, 3' ... 54 7e-09 2 dna update 2008.10.24 Homology vs Protein Score E Sequences producing significant alignments: (bits) Value.../CH/CHD6-A/CHD613Q.Seq.d/ 32 2.8 own update 2002.12.27 Homology vs DNA Score E Sequences producing significant alignments: (bits) Val...ue N ( BJ439713 ) Dictyostelium discoideum cDNA clone:dd

  14. 49 CFR 229.71 - Clearance above top of rail.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Suspension System § 229.71 Clearance above top of rail. No part or appliance of a locomotive except the wheels,...

  15. 17 CFR 229.1011 - (Item 1011) Additional information.

    Science.gov (United States)

    2010-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Mergers and Acquisitions (Regulation M-A) § 229..., controlling persons or subsidiaries and the subject company or any of its executive officers,...

  16. 48 CFR 229.402-70 - Additional clauses.

    Science.gov (United States)

    2010-10-01

    ... Germany, use the clause with its Alternate I. (b) Use the clause at 252.229-7002, Customs Exemptions (Germany), in solicitations and contracts requiring the import of U.S. manufactured products into...

  17. 22 CFR 229.455 - Textbooks and curricular material.

    Science.gov (United States)

    2010-04-01

    ... SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 229.455 Textbooks and curricular...

  18. 48 CFR 252.229-7008 - Relief from import duty (United Kingdom).

    Science.gov (United States)

    2010-10-01

    ... (United Kingdom). 252.229-7008 Section 252.229-7008 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.229-7008 Relief from import duty (United Kingdom). As prescribed in 229.402-70(h), use the following clause: Relief from Import Duty (United Kingdom) (JUN...

  19. 48 CFR 252.229-7006 - Value added tax exclusion (United Kingdom).

    Science.gov (United States)

    2010-10-01

    ... (United Kingdom). 252.229-7006 Section 252.229-7006 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.229-7006 Value added tax exclusion (United Kingdom). As prescribed in 229.402-70(f), use the following clause: Value Added Tax Exclusion (United Kingdom) (JUN...

  20. Excitation of the isomeric ^{229m}Th nuclear state via an electronic bridge process in ^{229}Th^+

    CERN Document Server

    Porsev, S G; Peik, E; Tamm, Chr

    2010-01-01

    We consider the excitation of the nuclear transition ^{229g}Th - ^{229m}Th near 7.6 eV in singly ionized thorium via an electronic bridge process. The process relies on the excitation of the electron shell by two laser photons whose sum frequency is equal to the nuclear transition frequency. This scheme allows to determine the nuclear transition frequency with high accuracy. Based on calculations of the electronic level structure of Th^+ which combine the configuration-interaction method and many-body perturbation theory, we estimate that a nuclear excitation rate in the range of 10 s^{-1} can be obtained using conventional laser sources.

  1. Phenotype abnormality: 229 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 229 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u735i decreased size ...in organ named whole plant during process named 0 seed germination stage ... whole plant ... decreased size ... 0 seed germination stage ...

  2. 22 CFR 229.125 - Effect of other requirements.

    Science.gov (United States)

    2010-04-01

    ... IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 229.125... local law or other requirements. The obligation to comply with these Title IX regulations is not obviated or alleviated by any State or local law or other requirement that would render any applicant or...

  3. 17 CFR 229.10 - (Item 10) General.

    Science.gov (United States)

    2010-04-01

    ... Corporate governance. Item 503 Prospectus summary, risk factors, and ratio of earnings to fixed charges... term is defined in Item 1101 of Regulation AB (§ 229.1101)), reference may not be made to any document... this part, the term smaller reporting company means an issuer that is not an investment company,...

  4. 12 CFR 229.51 - General provisions governing substitute checks.

    Science.gov (United States)

    2010-01-01

    ... which a bank has provided the warranties described in § 229.52 is the legal equivalent of an original... indorsements applied by parties that previously handled the check in any form (including the original check, a substitute check, or another paper or electronic representation of such original check or substitute...

  5. 30 CFR 229.123 - Standards for audit activities.

    Science.gov (United States)

    2010-07-01

    ... 229.123 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE... required, including a knowledge of accounting, auditing, agency regulations, and industry operations. (ii... statement of standards. (iii) The auditor's report should contain a statement of positive assurance on...

  6. 49 CFR 199.229 - Reporting of alcohol testing results.

    Science.gov (United States)

    2010-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.229 Reporting of alcohol testing results. (a) Each... 49 CFR part 40 (at § 40.25 and appendix H to part 40), not later than March 15 of each year for the...

  7. Extraction of 229Th From 233U Solution

    Institute of Scientific and Technical Information of China (English)

    XIAO; Guo-ping; ZHAO; Li-fei

    2013-01-01

    A two-step separation procedure for preparation of 229Th tracer from 233U was developed using CL-TBP and TEVA extraction chromatography.The decontamination factor of uranium from thorium is larger than 4.6×106.After separation,the content of 233U in uranium fraction was measured by ID-ICP-MS,

  8. 32 CFR 229.18 - Confidentiality of archaeological resource information.

    Science.gov (United States)

    2010-07-01

    ... § 229.18 Confidentiality of archaeological resource information. (a) The Federal land manager shall not... provision of law, information concerning the nature and location of any archaeological resource, with the... archaeological resource or area about which information is sought; (ii) The purpose for which the information...

  9. 49 CFR 240.229 - Requirements for joint operations territory.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Requirements for joint operations territory. 240... ENGINEERS Implementation of the Certification Process § 240.229 Requirements for joint operations territory... operating skills concerning the joint operations territory; and (iv) That the person certified as...

  10. 17 CFR 229.1000 - (Item 1000) Definitions.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Mergers and Acquisitions (Regulation M-A) § 229.1000 (Item... as in § 240.13e-3(a)(3) of this chapter; (f) Subject company means the company or entity...

  11. 17 CFR 229.1002 - (Item 1002) Subject company information.

    Science.gov (United States)

    2010-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Mergers and Acquisitions (Regulation M-A) § 229.1002 (Item 1002) Subject company information. (a) Name and address. State the name of the subject... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1002) Subject...

  12. 12 CFR 229.20 - Relation to state law.

    Science.gov (United States)

    2010-01-01

    ... Board may determine, upon the request of any state, bank, or other interested party, whether the EFA Act... provisions of state law with the corresponding provisions in the EFA Act and subparts A and B of this part... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Relation to state law. 229.20 Section...

  13. 28 CFR 2.29 - Release on parole.

    Science.gov (United States)

    2010-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.29 Release on... delivered to the prisoner. (b) An effective date of parole shall not be set for a date more than nine months...

  14. 22 CFR 229.400 - Education programs or activities.

    Science.gov (United States)

    2010-04-01

    ... SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 229.400 Education programs or activities... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Education programs or activities....

  15. 17 CFR 229.406 - (Item 406) Code of ethics.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 406) Code of ethics. 229... 406) Code of ethics. (a) Disclose whether the registrant has adopted a code of ethics that applies to... code of ethics, explain why it has not done so. (b) For purposes of this Item 406, the term code...

  16. 17 CFR 229.1106 - (Item 1106) Depositors.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1106 (Item... continuing duties of the depositor after issuance of the asset-backed securities being registered regarding the asset-backed securities or the pool assets. ...

  17. 17 CFR 229.1108 - (Item 1108) Servicers.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1108 (Item... to holders of the asset-backed securities, performing work-outs or foreclosures, or other aspect of the servicing of the pool assets or the asset-backed securities upon which the performance of the pool...

  18. 17 CFR 229.1105 - (Item 1105) Static pool information.

    Science.gov (United States)

    2010-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229... securities nor shall such information be deemed to be part of the registration statement for the asset-backed... or the registration statement for the asset-backed securities. (f) If any of the information...

  19. 17 CFR 229.1116 - (Item 1116) Tax matters.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1116 (Item... asset-backed securities transaction under federal income tax laws. (b) The material federal income tax consequences of purchasing, owning and selling the asset-backed securities. If any of the material federal...

  20. 17 CFR 229.1109 - (Item 1109) Trustees.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1109 (Item... experience serving as a trustee for asset-backed securities transactions involving similar pool assets, if applicable. (c) Describe the trustee's duties and responsibilities regarding the asset-backed securities...

  1. 17 CFR 229.1100 - (Item 1100) General.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1100 (Item... source of various disclosure items and requirements for “asset-backed securities” filings under the... this Regulation AB, including the definition of “asset-backed security,” are set forth in Item 1101. (b...

  2. 17 CFR 229.1101 - (Item 1101) Definitions.

    Science.gov (United States)

    2010-04-01

    ... AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1101 (Item... information regarding the asset-backed securities being offered and the structure and basic parameters of the...) Factual information regarding the pool assets underlying the asset-backed securities, including...

  3. 48 CFR 252.229-7004 - Status of contractors as a direct contractor (Spain).

    Science.gov (United States)

    2010-10-01

    ... direct contractor (Spain). 252.229-7004 Section 252.229-7004 Federal Acquisition Regulations System... contractor (Spain). As prescribed in 229.402-70(d), use the following clause: Status of Contractor as a Director Contractor (Spain) (JUN 1997) (a) “Direct Contractor,” as used in this clause, means an...

  4. 50 CFR 229.4 - Requirements for Category I and II fisheries.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Requirements for Category I and II fisheries. 229.4 Section 229.4 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC... FISHERIES UNDER THE MARINE MAMMAL PROTECTION ACT OF 1972 General Provisions § 229.4 Requirements...

  5. 17 CFR 229.1012 - (Item 1012) The solicitation or recommendation.

    Science.gov (United States)

    2010-04-01

    ... or recommendation. 229.1012 Section 229.1012 Commodity and Securities Exchanges SECURITIES AND... (Regulation M-A) § 229.1012 (Item 1012) The solicitation or recommendation. (a) Solicitation or recommendation. State the nature of the solicitation or the recommendation. If this statement relates to...

  6. 49 CFR 173.229 - Chloric acid solution or chlorine dioxide hydrate, frozen.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Chloric acid solution or chlorine dioxide hydrate, frozen. 173.229 Section 173.229 Transportation Other Regulations Relating to Transportation PIPELINE AND... Than Class 1 and Class 7 § 173.229 Chloric acid solution or chlorine dioxide hydrate, frozen. When the...

  7. 48 CFR 252.229-7010 - Relief from customs duty on fuel (United Kingdom).

    Science.gov (United States)

    2010-10-01

    ... on fuel (United Kingdom). 252.229-7010 Section 252.229-7010 Federal Acquisition Regulations System... (United Kingdom). As prescribed in 229.402-70(j), use the following clause: Relief from Customs Duty on Fuel (United Kingdom) (JUN 1997) (a) Pursuant to an agreement between the United States Government...

  8. 17 CFR 229.1208 - (Item 1208) Oil and gas properties, wells, operations, and acreage.

    Science.gov (United States)

    2010-04-01

    ... properties, wells, operations, and acreage. 229.1208 Section 229.1208 Commodity and Securities Exchanges... Registrants Engaged in Oil and Gas Producing Activities § 229.1208 (Item 1208) Oil and gas properties, wells, operations, and acreage. (a) Disclose, as of a reasonably current date or as of the end of the fiscal...

  9. 17 CFR 229.1008 - (Item 1008) Interest in securities of the subject company.

    Science.gov (United States)

    2010-04-01

    ..., SECURITIES EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Mergers and Acquisitions (Regulation M-A) § 229.1008 (Item 1008) Interest in securities of the subject company. (a... securities of the subject company. 229.1008 Section 229.1008 Commodity and Securities Exchanges...

  10. 22 CFR 229.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Educational institutions eligible to submit... Coverage § 229.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 229.300 through 229.310 apply that:...

  11. A VLBI survey at 2.29 GHz

    Science.gov (United States)

    Preston, R. A.; Morabito, D. D.; Williams, J. G.; Faulkner, J.; Jauncey, D. L.

    1985-01-01

    VLBI observations at 2.29 GHz with fringe spacings of about 3 milliarcsec have been performed on 1398 radio sources spread over the entire sky. 917 sources were detected, including 93 percent of the identified BL Lacertae objects, 86 percent of the quasars, and 36 percent of the galaxies. The resulting catalog of compact radio sources is useful for various astrophysical studies and in the formation of VLBI celestial reference frames.

  12. 20 CFR 229.68 - Reduction of DIB O/M.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Reduction of DIB O/M. 229.68 Section 229.68..., State, or Local Law or Plan § 229.68 Reduction of DIB O/M. A reduction for entitlement to worker's compensation or a public disability benefit is applied after the DIB O/M is reduced for age and the...

  13. Optical Spectroscopy of an Atomic Nucleus: Progress toward Direct Observation of the 229Th Isomer Transition

    Science.gov (United States)

    2011-09-28

    produce sufficiently high 229mTh-229gTh luminescence rates under excitation with a VUV source such as the ALS. Our preliminary studies find LiCAF to be an...hour per response, including the time for reviewing instructions, ~earchi ng existing data sources , gathering and maintaining the data needed, and...229mTh transition energy can be identified to within 0.1 nm by luminescence excitation and luminescence spectroscopy using the Advanced Light Source

  14. Performance of a 229 Thorium solid-state nuclear clock

    CERN Document Server

    Kazakov, G A; Romanenko, V I; Yatsenko, L P; Romanenko, A V; Schreitl, M; Winkler, G; Schumm, T

    2012-01-01

    The 7.8 eV nuclear isomer transition in 229 Thorium has been suggested as an etalon transition in a new type of optical frequency standard. Here we discuss the construction of a "solid-state nuclear clock" from Thorium nuclei implanted into single crystals transparent in the vacuum ultraviolet range. We investigate crystal-induced line shifts and broadening effects for the specific system of Calcium fluoride. At liquid Nitrogen temperatures, the clock performance will be limited by decoherence due to magnetic coupling of the Thorium nucleus to neighboring nuclear moments, ruling out the commonly used Rabi or Ramsey interrogation schemes. We propose a clock stabilization based on counting of flourescence photons and present optimized operation parameters. Taking advantage of the high number of quantum oscillators under continuous interrogation, a fractional instability level of 10^{-19} might be reached within the solid-state approach.

  15. 30 CFR 229.106 - Withdrawal of Indian lands from delegated authority.

    Science.gov (United States)

    2010-07-01

    ....106 Withdrawal of Indian lands from delegated authority. If at any time an Indian tribe or an... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Withdrawal of Indian lands from delegated authority. 229.106 Section 229.106 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...

  16. 22 CFR 229.440 - Health and insurance benefits and services.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Health and insurance benefits and services. 229... benefits and services. Subject to § 229.235(d), in providing a medical, hospital, accident, or life insurance benefit, service, policy, or plan to any of its students, a recipient shall not discriminate...

  17. 49 CFR Appendix D to Part 229 - Criteria for Certification of Crashworthy Event Recorder Memory Module

    Science.gov (United States)

    2010-10-01

    ... Recorder Memory Module D Appendix D to Part 229 Transportation Other Regulations Relating to Transportation... Memory Module Section 229.135(b) requires that certain locomotives be equipped with an event recorder that includes a certified crashworthy event recorder memory module. This appendix prescribes the...

  18. 40 CFR 264.229 - Special requirements for ignitable or reactive waste.

    Science.gov (United States)

    2010-07-01

    ... reactive waste. 264.229 Section 264.229 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE... impoundment satisfy all applicable requirements of 40 CFR part 268, and: (a) The waste is treated,...

  19. 42 CFR 436.229 - Optional targeted low-income children.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Optional targeted low-income children. 436.229... Options for Coverage as Categorically Needy Options for Coverage of Families and Children and Aged, Blind, and Disabled Individuals, Including Pregnant Women § 436.229 Optional targeted low-income children...

  20. 42 CFR 435.229 - Optional targeted low-income children.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Optional targeted low-income children. 435.229... Coverage of Families and Children § 435.229 Optional targeted low-income children. The agency may provide Medicaid to— (a) All individuals under age 19 who are optional targeted low-income children as defined in...

  1. 50 CFR 229.7 - Monitoring of incidental mortalities and serious injuries.

    Science.gov (United States)

    2010-10-01

    ... serious injuries. 229.7 Section 229.7 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL... mortalities and serious injuries. (a) Purpose. The Assistant Administrator will establish a program to monitor incidental mortality and serious injury of marine mammals during the course of commercial fishing operations...

  2. 40 CFR 52.229 - Control strategy and regulations: Photochemical oxidants (hydrocarbons), Metropolitan Los Angeles...

    Science.gov (United States)

    2010-07-01

    ...: Photochemical oxidants (hydrocarbons), Metropolitan Los Angeles Intrastate Region. 52.229 Section 52.229... oxidants (hydrocarbons), Metropolitan Los Angeles Intrastate Region. (a) (b) The following rules are... and approved for the SIP, remain federally enforceable: (1) Los Angeles County APCD, Regulation IV...

  3. 25 CFR 162.229 - How long can the term of an agricultural lease run?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How long can the term of an agricultural lease run? 162.229 Section 162.229 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LEASES... lease run? (a) An agricultural lease must provide for a definite lease term, specifying the...

  4. 17 CFR 229.202 - (Item 202) Description of registrant's securities.

    Science.gov (United States)

    2010-04-01

    ... shall be included in response to this item. 6. For asset-backed securities, see also Item 1113 of... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 202) Description of registrant's securities. 229.202 Section 229.202 Commodity and Securities Exchanges SECURITIES AND EXCHANGE...

  5. Clinical and histopathological review of 229 cases of ranula.

    Science.gov (United States)

    Jia, Yulin; Zhao, Yifang; Chen, Xinming

    2011-10-01

    The purpose of this paper was to evaluate the relationship between the thrombosis and secretory duct dilation, lesion size, clinical types, nature (primary or recurrent) and duration of illness in the development of ranula. A total of 229 cases of sublingual gland cysts were treated with surgical resection from Jan. 1990 to Feb. 2010. The patients' data were investigated on histopathological findings, size of ranula, the clinical types, nature of ranula (primary or recurrent) and duration of illness. Sections from the paraffin-embedded blocks were HE-stained. CK expression was immunohistochemically detected. Among 229 cases the incidence of venous thrombosis was 58.52%. The incidence of venous thrombosis with or without duct dilation was 73.25% and 26.39% respectively, with a significant difference between the two groups (Pranulas with diameter larger or less than 3 cm was 72.22% and 46.28% (Pranula, plunging ranula and mixed ranula was 49.37%, 77.19% and 85.71% respectively, with a significant difference found between oral and plunging or mixed ranula (Pranula patients with duration of illness longer or less than 3 months was 69.77% and 51.75% (Pranulas was 51.85% and 64.85%, without a significant difference noted between them (P>0.05). It is concluded that the formation of venous thrombosis was related to the dilation of secretory duct, lesion size, clinical types, duration of lesion but formation of venous thrombosis was not related to the nature (primary or recurrent) of ranulas.

  6. Characterization of mouse CD229 (Ly9), a leukocyte cell surface molecule of the CD150 (SLAM) family.

    Science.gov (United States)

    Sintes, J; Vidal-Laliena, M; Romero, X; Tovar, V; Engel, P

    2007-11-01

    Mouse CD229 (Ly9) is a cell surface molecule of the CD150 (signaling lymphocyte activation molecule) family. This family consists of nine leukocyte receptors of the immunoglobulin superfamily that are involved in leukocyte activation. CD229 binds to SAP, a protein encoded by the gene for X-linked lymphoproliferative disease. In this study, mouse CD229 expression was assessed with a new CD229-specific monoclonal antibody (mAb) (Ly9.ab3), raised using CD229-transfected cells. CD229 was expressed on Sca-1+c-kit+Lin- hematopoietic stem cells, and this expression increased during lymphocyte maturation. Virtually, all T and B cells expressed high levels of CD229. CD229 was absent on granulocytes, bone marrow-derived dendritic cells, platelets, and red blood cells (RBCs). However, it was expressed at significant levels on monocytes, indicating that it is also expressed on mouse myeloid cells. We also show that natural killer cells, natural killer T cells, and B1 cells express very high levels of this molecule. In vitro functional experiments showed that ligation of CD229 inhibited the expression of the activation markers CD69 and CD25 on T lymphocytes in response to anti-CD3 stimulation. Moreover, this reduced activation was concurrent with a reduction in cytokine production. Our results show that CD229 is a pan-lymphocyte marker and indicate that mAbs against CD229 are able to down-modulate T-cell activation.

  7. 22 CFR 229.110 - Remedial and affirmative action and self-evaluation.

    Science.gov (United States)

    2010-04-01

    ... Introduction § 229.110 Remedial and affirmative action and self-evaluation. (a) Remedial action. If the... recipient may take affirmative action consistent with law to overcome the effects of conditions that...

  8. 20 CFR 229.82 - Failure to have child in care.

    Science.gov (United States)

    2010-04-01

    ... her care, is under retirement age and is no longer caring for an eligible child. However, if the... SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Miscellaneous Deductions and Reductions § 229.82 Failure...

  9. Surface molecule CD229 as a novel target for the diagnosis and treatment of multiple myeloma.

    Science.gov (United States)

    Atanackovic, Djordje; Panse, Jens; Hildebrandt, York; Jadczak, Adam; Kobold, Sebastian; Cao, Yanran; Templin, Julia; Meyer, Sabrina; Reinhard, Henrike; Bartels, Katrin; Lajmi, Nesrine; Zander, Axel R; Marx, Andreas H; Bokemeyer, Carsten; Kröger, Nicolaus

    2011-10-01

    To date, multiple myeloma remains an incurable malignancy due to the persistence of minimal residual disease in the bone marrow. In this setting, monoclonal antibodies against myeloma-specific cell surface antigens represent a promising therapeutic approach, which is however hampered by a lack of appropriate target structures expressed across all pathogenic myeloma cell populations. We, therefore, investigated functionally relevant immunoreceptors specifically associated with myeloma cells as well as their clonogenic precursors. Potential target proteins were identified using antibody arrays against phosphorylated immunoreceptors with lysates from myeloma cell lines. CD229 expression was confirmed in primary myeloma cells by reverse transcriptase polymerase chain reaction, western blot, fluorescence-activated cell sorting, and immunohistochemistry. Apoptosis, clonogenic growth, and sensitivity to chemotherapy were determined following short-interfering RNA-mediated downregulation of CD229. Antibody-dependent cellular and complement-dependent cytotoxicity were analyzed using a monoclonal antibody against CD229 to demonstrate the antigen's immunotherapeutic potential. Our screening assay identified CD229 as the most strongly over-expressed/phosphorylated immunoreceptor in myeloma cell lines. Over-expression was further demonstrated in the CD138-negative population, which has been suggested to represent myeloma precursors, as well as on primary tumor cells from myeloma patients. Accordingly, CD229 staining of patients' bone marrow samples enabled the identification of myeloma cells by flow cytometry and immunohistochemistry. Down-regulation of CD229 led to a decreased number of viable myeloma cells and clonal myeloma colonies, and enhanced the anti-tumor activity of conventional chemotherapeutics. Targeting CD229 with a monoclonal antibody resulted in complement- and cell-mediated lysis of myeloma cells. Our results demonstrate that the immunoreceptor CD229 is

  10. Continuous-wave, single-frequency 229 nm laser source for laser cooling of cadmium atoms

    CERN Document Server

    Kaneda, Yushi; Merzlyak, Yevgeny; Yamaguchi, Atsushi; Hayashida, Keitaro; Ohmae, Noriaki; Katori, Hidetoshi

    2016-01-01

    Continuous-wave output at 229 nm for the application of laser cooling of Cd atoms was generated by the 4th harmonic using two successive second harmonic generation stages. Employing a single-frequency optically pumped semiconductor laser as a fundamental source, 0.56 W of output at 229 nm was observed with a 10-mm long, Brewster-cut BBO crystal in an external cavity with 1.62 W of 458 nm input. Conversion efficiency from 458 nm to 229 nm was more than 34%. By applying a tapered amplifier as a fundamental source, we demonstrated magneto-optical trapping of all stable Cd isotopes including isotopes $^{111}$Cd and $^{113}$Cd, which are applicable to optical lattice clocks.

  11. The Near-infrared Spectrum of the Brown Dwarf Gliese 229B

    OpenAIRE

    Geballe, T. R.; Kulkarni, S.R.; Woodward, C. E.; Sloan, G.C.

    1996-01-01

    A medium resolution 1.0-2.5um spectrum of the brown dwarf, Gliese 229B has been obtained using CGS4 on UKIRT. In addition to the broad spectral structure seen in earlier low resolution observations, the new spectrum reveals a large number of absorption lines, many of which can be identified with water vapor. Water and methane are both shown to be strong absorbers in the near-infrared spectrum of the object. Several spectral features in Gl 229B that are attributable to methane match ones seen ...

  12. 17 CFR 229.304 - (Item 304) Changes in and disagreements with accountants on accounting and financial disclosure.

    Science.gov (United States)

    2010-04-01

    ... disagreements with accountants on accounting and financial disclosure. 229.304 Section 229.304 Commodity and... accounting and financial disclosure. (a)(1) If during the registrant's two most recent fiscal years or any... any matter of accounting principles or practices, financial statement disclosure, or auditing scope...

  13. 48 CFR 252.229-7009 - Relief from customs duty and value added tax on fuel (passenger vehicles) (United Kingdom).

    Science.gov (United States)

    2010-10-01

    ... and value added tax on fuel (passenger vehicles) (United Kingdom). 252.229-7009 Section 252.229-7009... Relief from customs duty and value added tax on fuel (passenger vehicles) (United Kingdom). As prescribed... (Passenger Vehicles) (United Kingdom) (JUN 1997) (a) Pursuant to an agreement between the United...

  14. Characterization of the expression and immunogenicity of the ns4b protein of human coronavirus 229E

    DEFF Research Database (Denmark)

    Chagnon, F; Lamarre, A; Lachance, C

    1998-01-01

    and immunogenicity of the ns4b gene product from strain 229E of human coronavirus (HCV-229E), a respiratory virus with a neurotropic potential. The gene was cloned and expressed in bacteria. A fusion protein of ns4b with maltose-binding protein was injected into rabbits to generate specific antibodies that were used...

  15. Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229.

    Science.gov (United States)

    Martín, Margarita; Del Valle, Juana M; Saborit, Ifigènia; Engel, Pablo

    2005-05-15

    Ag recognition by the TCR determines the subsequent fate of the T cell and is regulated by the involvement of other cell surface molecules, termed coreceptors. CD229 is a lymphocyte cell surface molecule that belongs to the CD150 family of receptors. Upon tyrosine phosphorylation, CD229 recruits various signaling molecules to the membrane. One of these molecules is the signaling lymphocytic activation molecule-associated protein, of which a deficiency leads to the X-linked lymphoproliferative syndrome. We report that CD229 interacts in a phosphorylation-dependent manner with Grb2. We mapped this interaction showing that the Src homology 2 domain of Grb2 and the tyrosine residue Y606 in CD229 are required for CD229-Grb2 complex formation. The Grb2 motif in the cytoplasmic tail of CD229 is distinct and independent from the two tyrosines required for efficient signaling lymphocytic activation molecule-associated protein recruitment. CD229, but not other members of the CD150 family, directly bound Grb2. We also demonstrate that CD229 precipitates with Grb2 in T lymphocytes after pervanadate treatment, as well as CD229 or TCR ligation. Interestingly, the CD229 mutant lacking the Grb2 binding site is not internalized after CD229 engagement with specific Abs. Moreover, a dominant negative form of Grb2 (containing only Src homology 2 domain) impaired CD229 endocytosis. Unexpectedly, Erk phosphorylation was partially inhibited after activation of CD229 plus CD3. Consistent with this, CD229 ligation partially inhibited TCR signaling in peripheral blood cells and CD229-Jurkat cells transfected with the 3XNFAT-luciferase reporter construct. Altogether, the data suggest a model whereby CD229 ligation attenuates TCR signaling and Grb2 recruitment to CD229 controls its rate of internalization.

  16. CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse.

    Science.gov (United States)

    Romero, Xavier; Zapater, Nuria; Calvo, María; Kalko, Susana G; de la Fuente, Miguel Angel; Tovar, Victoria; Ockeloen, Charlotte; Pizcueta, Pilar; Engel, Pablo

    2005-06-01

    CD229 is a member of the CD150 family of the Ig superfamily expressed on T and B cells. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells. The cytoplasmic tail of CD229 binds to SAP, a protein that is defective in X-linked lymphoproliferative syndrome. To identify the CD229 ligand, we generated a soluble Ig fusion protein containing the two N-terminal extracellular domains of human CD229 (CD229-Ig). CD229-Ig bound to CD229-transfected cells, whereas no binding was detected on cells expressing other CD150 family receptors, showing that CD229 binds homophilically. Both human and mouse CD229 interacted with itself. Domain deletion mutants showed that the N-terminal Ig-domain mediates homophilic adhesion. CD229-CD229 binding was severely compromised when the charged amino acids E27 and E29 on the predicted B-C loop and R89 on the F-G loop of the N-terminal domain were mutated to alanine. In contrast, one mutation, R44A, enhanced the homophilic interaction. Confocal microscopy image analysis revealed relocalization of CD229 to the contact area of T and B cells during Ag-dependent immune synapse formation. Thus, CD229 is its own ligand and participates in the immunological synapse.

  17. Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease.

    Science.gov (United States)

    Shirato, Kazuya; Imada, Yoshio; Kawase, Miyuki; Nakagaki, Keiko; Matsuyama, Shutoku; Taguchi, Fumihiro

    2014-12-01

    Although human coronavirus (HCoV)-NL63 was once considered a possible causative agent of Kawasaki disease based on RT-PCR analyses, subsequent studies could not confirm the result. In this study, this possibility was explored using serological tests. To evaluate the role of HCoV infection in patients with Kawasaki disease, immunofluorescence assays and virus neutralizing tests were performed. Paired serum samples were obtained from patients with Kawasaki disease who had not been treated with γ-globulin. HCoV-NL63 and two antigenically different isolates of HCoV-229E (ATCC-VR740 and a new isolate, Sendai-H) were examined as controls. Immunofluorescence assays detected no difference in HCoV-NL63 antibody positivity between the patients with Kawasaki disease and controls, whereas the rate of HCoV-229E antibody positivity was higher in the patients with Kawasaki disease than that in controls. The neutralizing tests revealed no difference in seropositivity between the acute and recovery phases of patients with Kawasaki disease for the two HCoV-229Es. However, the Kawasaki disease specimens obtained from patients in recovery phase displayed significantly higher positivity for Sendai-H, but not for ATCC-VR740, as compared to the controls. The serological test supported no involvement of HCoV-NL63 but suggested the possible involvement of HCoV-229E in the development of Kawasaki disease. © 2014 Wiley Periodicals, Inc.

  18. 17 CFR 229.1003 - (Item 1003) Identity and background of filing person.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1003) Identity and... (Regulation M-A) § 229.1003 (Item 1003) Identity and background of filing person. (a) Name and address. State... the Internet, state the address where the information can be found....

  19. 49 CFR 229.85 - Doors and cover plates marked “Danger”.

    Science.gov (United States)

    2010-10-01

    ... System § 229.85 Doors and cover plates marked “Danger”. All doors and cover plates guarding high voltage equipment shall be marked “Danger—High Voltage” or with the word “Danger” and the normal voltage carried...

  20. 22 CFR 229.550 - Sex as a bona fide occupational qualification.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Sex as a bona fide occupational qualification... THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 229.550 Sex...

  1. Yeast Interacting Proteins Database: YMR047C, YDR229W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available R229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially...holipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vp

  2. 17 CFR 229.308T - (Item 308T) Internal control over financial reporting.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 308T) Internal control... § 229.308T (Item 308T) Internal control over financial reporting. Note to Item 308T: This is a special... internal control over financial reporting. Provide a report of management on the registrant's...

  3. 17 CFR 229.308 - (Item 308) Internal control over financial reporting.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 308) Internal control... § 229.308 (Item 308) Internal control over financial reporting. (a) Management's annual report on internal control over financial reporting. Provide a report of management on the registrant's...

  4. Nanotechnology Standardization Activities – Support of U.S. Representation on ISO/TC 229 Nanotechnologies

    Energy Technology Data Exchange (ETDEWEB)

    Benko, Heather [American National Standards Inst. (ANSI), Washington, DC (United States)

    2017-03-14

    In carrying out its responsibilities on behalf of the United States, ANSI provides comprehensive, administrative support and expertise on international protocols and procedures to: (1) the U.S. Technical Advisory Group (TAG) to the International Organization for Standardization’s (ISO) Technical Committee (TC) 229 Nanotechnologies, and (2) the corresponding U.S. TAG Working Groups tasked with formulating U.S. positions on topics relevant to nanotechnology standardization. Additionally, secretariat and procedural support is provided for the ISO/TC 229 WG 3 on health, safety and environment, for which the United States was assigned leadership by the participating national body members of ISO/TC 229. As the official entity that serves as the U.S. representative to ISO, ANSI provides not only expert coordination of U.S. positions and representation at ISO but also strategic direction, advice and procedural expertise to facilitate navigation of international issues to promote U.S. positions for incorporation into the ISO/TC 229 program of work necessary to support U.S. objectives.

  5. 20 CFR 229.50 - Age reduction in employee or spouse benefit.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Computation of the Overall Minimum Rate § 229.50 Age... the employee's child under 16 years old or disabled before attaining age 22 in his or her care, is... her care. (b) Employee age reduction. The Overall Minimum PIA plus any delayed retirement credits...

  6. 77 FR 3255 - Notice of 229 Boundary Revision at the Paducah Gaseous Diffusion Plant

    Science.gov (United States)

    2012-01-23

    ... entry into or upon areas, buildings, and other facilities of the Paducah Gaseous Diffusion Plant... No: 2012-1214] DEPARTMENT OF ENERGY Notice of 229 Boundary Revision at the Paducah Gaseous Diffusion... provided in 10 CFR 860.4, into or upon this facility, installation, or real property of the Paducah...

  7. 22 CFR 229.420 - Access to schools operated by LEAs.

    Science.gov (United States)

    2010-04-01

    ... SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 229.420 Access to schools operated by LEAs... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Access to schools operated by LEAs....

  8. 50 CFR 229.31 - Pacific Offshore Cetacean Take Reduction Plan.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Pacific Offshore Cetacean Take Reduction... Regulations § 229.31 Pacific Offshore Cetacean Take Reduction Plan. (a) Purpose and scope. The purpose of this section is to implement the Pacific Offshore Cetacean Take Reduction Plan. Paragraphs (b) through (d)...

  9. 17 CFR 229.1007 - (Item 1007) Source and amount of funds or other consideration.

    Science.gov (United States)

    2010-04-01

    ..., SECURITIES EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Mergers and Acquisitions (Regulation M-A) § 229.1007 (Item 1007) Source and amount of funds or other consideration. (a... and state whether or not the subject company has paid or will be responsible for paying any or...

  10. 17 CFR 229.1004 - (Item 1004) Terms of the transaction.

    Science.gov (United States)

    2010-04-01

    ... ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Mergers and Acquisitions (Regulation M-A) § 229... consequences of the transaction, if material. (2) Mergers or similar transactions. In the case of a merger or... are to be purchased from any officer, director or affiliate of the subject company and provide...

  11. 17 CFR 229.1009 - (Item 1009) Persons/assets, retained, employed, compensated or used.

    Science.gov (United States)

    2010-04-01

    ..., SECURITIES EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Mergers and Acquisitions (Regulation M-A) § 229.1009 (Item 1009) Persons/assets, retained, employed, compensated or used... corporate assets of the subject company that has been or will be employed or used by the filing person...

  12. 22 CFR 229.205 - Educational institutions and other entities controlled by religious organizations.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Educational institutions and other entities... FINANCIAL ASSISTANCE Coverage § 229.205 Educational institutions and other entities controlled by religious...) Exemption claims. An educational institution or other entity that wishes to claim the exemption set forth...

  13. 22 CFR 229.210 - Military and merchant marine educational institutions.

    Science.gov (United States)

    2010-04-01

    ... Coverage § 229.210 Military and merchant marine educational institutions. These Title IX regulations do not apply to an educational institution whose primary purpose is the training of individuals for a military... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Military and merchant marine...

  14. 22 CFR 229.425 - Counseling and use of appraisal and counseling materials.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Counseling and use of appraisal and counseling... Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 229.425 Counseling and use of appraisal and counseling materials. (a) Counseling. A recipient shall not discriminate against any person...

  15. Measuring the Th-229 nuclear isomer transition with U-233 doped crystals

    CERN Document Server

    Stellmer, Simon; Kazakov, Georgy; Sterba, Johannes; Schumm, Thorsten

    2015-01-01

    We propose a simple approach to measure the energy of the few-eV isomeric state in Th-229. To this end, U-229 nuclei are doped into VUV-transparent crystals, where they undergo alpha decay into Th-229, and, with a probability of 2%, populate the isomeric state. These Th-229m nuclei may decay into the nuclear ground state under emission of the sought-after VUV gamma, whose wavelength can be determined with a spectrometer. Based on measurements of the optical transmission of U:CaF2 crystals in the VUV range, we expect a signal at least 2 orders of magnitude larger compared to current schemes using surface-implantation of recoil nuclei. The signal background is dominated by Cherenkov radiation induced by beta decays of the thorium decay chain. We estimate that, even if the isomer undergoes radiative de-excitation with a probability of only 0.1%, the VUV gamma can be detected within a reasonable measurement time.

  16. 17 CFR 229.1119 - (Item 1119) Affiliations and certain relationships and related transactions.

    Science.gov (United States)

    2010-04-01

    ... Asset-Backed Securities (Regulation AB) § 229.1119 (Item 1119) Affiliations and certain relationships... 1115 of this Regulation AB. (6) Any other material parties related to the asset-backed securities...'s length transaction with an unrelated third party, apart from the asset-backed securities...

  17. 14 CFR 417.229 - Far-field overpressure blast effects analysis.

    Science.gov (United States)

    2010-01-01

    ... to potential explosions during launch vehicle flight and demonstrate compliance with the public risk... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.229 Far-field overpressure blast effects analysis. (a) General. A flight safety analysis must establish flight commit...

  18. 229例成人甲型流感患者临床特征分析%Clinical features of 229 cases of adults influenza

    Institute of Scientific and Technical Information of China (English)

    李雪辉; 吕楠; 陈杭薇; 王慧敏

    2011-01-01

    目的 分析229例确诊甲型流感(简称甲流)患者的临床特征.方法 我院发热门诊中489例较典型流感样症状患者取鼻、咽拭子送流感网络实验室行流感病毒实时聚合酶链式反应检测.结果 共检出甲流患者229例,其中非甲型H1N1流感患者178例,甲型H1N1流感患者51例,主要检出月份在2009年8-11月,患者从发病到就诊时间平均为(1.76±1.14)d.甲流患者中咽痛、咳嗽、咯痰、鼻塞、打喷嚏、流鼻涕、四肢酸痛发生率较高.但非甲型H1N1流感和甲型H1N1流感患者症状之间差异无统计学意义.甲流患者主要为青壮年人,但与非甲型H1N1流感患者相比,甲型H1N1流感患者的平均年龄较小.结论 甲流患者较非甲流患者咽痛、咳嗽、咯痰、鼻塞、打喷嚏、流鼻涕、四肢酸痛发生率高,给临床医师以提示,但无特异性.%Objective To analyze clinical features of 229 confirmed influenza A patients. Methods 489 cases had typical influenza-like symptoms, the nasopharyngeal swabs of the 489 cases were took and sent to CDC influenza network laboratory for influenza A real time polymerase chain reaction test. Results Among the 489 cases, there were 229 influenza A positive patients, 178 of 229 cases were normal influenza A positive patients, 51 of 229 cases were influenza A H1N1 patients. The influenza A positive cases were mainly tested from August to December in 2009, the time from disease onset to visiting hospital was (1. 76 ± 1. 14) days. Compare with the influenza negative patients, symptoms such as sore throat, cough, expectoration, nasal congestion, sneezing,and runny nose were more frequently observed in influenza virus A-positive patients. But the symptoms between normal influenza A and influenza A H1N1 had no significant difference. The influenza A positive patients were mainly young, but the influenza A H1N1 patients were younger than normal influenza A patients. Conclusions The symptoms of influenza A

  19. BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surface

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Shiu-Mei [Department of Medical Research and Education, Taipei Veterans General Hospital and Institute of Clinical Medicine, Taipei 11217, Taiwan (China); Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan (China); Huang, Kuo-Jung [Department of Medical Research and Education, Taipei Veterans General Hospital and Institute of Clinical Medicine, Taipei 11217, Taiwan (China); Wang, Chin-Tien, E-mail: chintien@ym.edu.tw [Department of Medical Research and Education, Taipei Veterans General Hospital and Institute of Clinical Medicine, Taipei 11217, Taiwan (China); Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan (China)

    2014-01-20

    Bone marrow stromal antigen 2 (BST2), an interferon-inducible antiviral factor, has been shown to block the release of various enveloped viruses from cells. It has also been identified as an innate immune system component. Most enveloped viruses subject to BST2 restriction bud at the plasma membrane. Here we report our findings that (a) the production of human coronavirus 229E (HCoV-229E) progeny viruses, whose budding occurs at the ER-Golgi intermediate compartment (ERGIC), markedly decreases in the presence of BST2; and (b) BST2 knockdown expression results in enhanced HCoV-229E virion production. Electron microscopy analyses indicate that HCoV-229E virions are tethered to cell surfaces or intracellular membranes by BST2. Our results suggest that BST2 exerts a broad blocking effect against enveloped virus release, regardless of whether budding occurs at the plasma membrane or intracellular compartments. - Highlights: • BST2 knockdown expression results in enhanced HCoV-229E egress. • HCoV-229E virions are tethered to cell surfaces or intracellular membranes by BST2. • HCoV-229E infection at high MOI can significantly downregulate HeLa BST2 and rescue HIV-1 egress.

  20. Broad-line Reverberation in the Kepler-field Seyfert Galaxy Zw 229-015

    Science.gov (United States)

    Barth, Aaron J.; Nguyen, My L.; Malkan, Matthew A.; Filippenko, Alexei V.; Li, Weidong; Gorjian, Varoujan; Joner, Michael D.; Bennert, Vardha Nicola; Botyanszki, Janos; Cenko, S. Bradley; Childress, Michael; Choi, Jieun; Comerford, Julia M.; Cucciara, Antonino; da Silva, Robert; Duchêne, Gaspard; Fumagalli, Michele; Ganeshalingam, Mohan; Gates, Elinor L.; Gerke, Brian F.; Griffith, Christopher V.; Harris, Chelsea; Hintz, Eric G.; Hsiao, Eric; Kandrashoff, Michael T.; Keel, William C.; Kirkman, David; Kleiser, Io K. W.; Laney, C. David; Lee, Jeffrey; Lopez, Liliana; Lowe, Thomas B.; Moody, J. Ward; Morton, Alekzandir; Nierenberg, A. M.; Nugent, Peter; Pancoast, Anna; Rex, Jacob; Rich, R. Michael; Silverman, Jeffrey M.; Smith, Graeme H.; Sonnenfeld, Alessandro; Suzuki, Nao; Tytler, David; Walsh, Jonelle L.; Woo, Jong-Hak; Yang, Yizhe; Zeisse, Carl

    2011-05-01

    The Seyfert 1 galaxy Zw 229-015 is among the brightest active galaxies being monitored by the Kepler mission. In order to determine the black hole mass in Zw 229-015 from Hβ reverberation mapping, we have carried out nightly observations with the Kast Spectrograph at the Lick 3 m telescope during the dark runs from 2010 June through December, obtaining 54 spectroscopic observations in total. We have also obtained nightly V-band imaging with the Katzman Automatic Imaging Telescope at Lick Observatory and with the 0.9 m telescope at the Brigham Young University West Mountain Observatory over the same period. We detect strong variability in the source, which exhibited more than a factor of two change in broad Hβ flux. From cross-correlation measurements, we find that the Hβ light curve has a rest-frame lag of 3.86+0.69 -0.90 days with respect to the V-band continuum variations. We also measure reverberation lags for Hα and Hγ and find an upper limit to the Hδ lag. Combining the Hβ lag measurement with a broad Hβ width of σline = 1590 ± 47 km s-1 measured from the rms variability spectrum, we obtain a virial estimate of M BH = 1.00+0.19 -0.24 × 107 M sun for the black hole in Zw 229-015. As a Kepler target, Zw 229-015 will eventually have one of the highest-quality optical light curves ever measured for any active galaxy, and the black hole mass determined from reverberation mapping will serve as a benchmark for testing relationships between black hole mass and continuum variability characteristics in active galactic nuclei.

  1. Investment in the Meirama industrial complex reaches 59,229 million pesetas

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    This paper gives an account of the project to build a thermoelectric power station complex in the Meirama Valley (La Coruna, Spain) with a 550 MW capacity and burning the lignite deposits located in the same valley. These deposits contain 85 million tons of economically workable reserves and the production figure is four million tons per annum. The requisite investment in the project is now 59,229 million pesetas. (In Spanish)

  2. Towards a direct transition energy measurement of the lowest nuclear excitation in 229Th

    CERN Document Server

    Wense, L v d; Kalb, D; Laatiaoui, M

    2012-01-01

    The isomeric first excited state of the isotope 229Th exhibits the lowest nuclear excitation energy in the whole landscape of known atomic nuclei. For a long time this energy was reported in the literature as 3.5(5) eV, however, a new experiment corrected this energy to 7.6(5) eV, corresponding to a UV transition wavelength of 163(11) nm. The expected isomeric lifetime is $\\tau=$ 3-5 hours, leading to an extremely sharp relative linewidth of Delta E/E ~ 10^-20, 5-6 orders of magnitude smaller than typical atomic relative linewidths. For an adequately chosen electronic state the frequency of the nuclear ground-state transition will be independent from influences of external fields in the framework of the linear Zeeman and quadratic Stark effect, rendering 229mTh a candidate for a reference of an optical clock with very high accuracy. Moreover, in the literature speculations about a potentially enhanced sensitivity of the ground-state transition of $^{229m}$Th for eventual time-dependent variations of fundament...

  3. Antiseptic properties of two calix[4]arenes derivatives on the human coronavirus 229E.

    Science.gov (United States)

    Geller, C; Fontanay, S; Mourer, M; Dibama, H Massimba; Regnouf-de-Vains, J-B; Finance, C; Duval, R E

    2010-12-01

    Facing the lack in specific antiviral treatment, it is necessary to develop new means of prevention. In the case of the Coronaviridae this family is now recognized as including potent human pathogens causing upper and lower respiratory tract infections as well as nosocomial ones. Within the purpose of developing new antiseptics molecules, the antiseptic virucidal activity of two calix[4]arene derivatives, the tetra-para-sulfonato-calix[4]arene (C[4]S) and the 1,3-bis(bithiazolyl)-tetra-para-sulfonato-calix[4]arene (C[4]S-BTZ) were evaluated toward the human coronavirus 229E (HCoV 229E). Comparing these results with some obtained previously with chlorhexidine and hexamidine, (i) these two calixarenes did not show any cytotoxicity contrary to chlorhexidine and hexamidine, (ii) C[4]S showed as did hexamidine, a very weak activity against HCoV 229E, and (iii) the C[4]S-BTZ showed a stronger activity than chlorhexidine, i.e. 2.7 and 1.4log₁₀ reduction in viral titer after 5min of contact with 10⁻³mol L⁻¹ solutions of C[4]S-BTZ and chlorhexidine, respectively. Thus, the C[4]S-BTZ appeared as a promising virucidal (antiseptic) molecule.

  4. Molecular Abundances in the Atmosphere of the T Dwarf Gl 229B

    CERN Document Server

    Saumon, D S; Leggett, S K; Marley, M S; Freedman, R S; Lodders, K; Fegley, B; Sen-Gupta, S K

    2000-01-01

    We present new, high resolution, infrared spectra of the T dwarf Gliese 229B in the J, H, and K bandpasses. We analyze each of these as well as previously published spectra to determine its metallicity and the abundances of NH3 and CO in terms of the surface gravity of Gl 229B, which remains poorly constrained. The metallicity increases with increasing gravity and is below the solar value unless Gl 229B is a high-gravity brown dwarf with log g(cgs) ~ 5.5. The NH3 abundance is determined from both the H and the K band spectra which probe two different levels in the atmosphere. We find that the abundance from the K band data is well below that expected from chemical equilibrium, which we interpret as strong evidence for dynamical transport of NH3 in the atmosphere. This is consistent with the previous detection of CO and provides additional constraints on the dynamics of the atmosphere of this T dwarf.

  5. The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).

    Science.gov (United States)

    Del Valle, Juana M; Engel, Pablo; Martín, Margarita

    2003-05-09

    CD229 (Ly9) is a cell surface receptor selectively expressed on T and B lymphocytes, and it belongs to the CD150 receptor family. Like other receptors of this family, CD229 interacts with SAP/SH2D1a protein, mutation of which is responsible for the fatal X-linked lymphoproliferative disease. Receptors of the CD150 family function as costimulatory molecules, regulating cytokine production and cytotoxicity. Thus, their signaling and regulation in lymphocytes may be critical to an understanding of the pathogenesis of the X-linked lymphoproliferative disease. Here we show that CD229 interacts with the mu(2) chain of the AP-2 adaptor complex that links transmembrane proteins to clathrin-coated pits. CD229 was the only member of the CD150 family associated with AP-2. We also show that the mu(2) chain interacts with the Y(470)EKL motif of CD229. The integrity of this site was necessary for CD229 internalization, but it was not involved in SAP recruitment. Moreover, CD229 binds to the AP-2 complex in T and B cell lines, and it is internalized rapidly from the cell surface on T cells after antibody ligation. In contrast, cross-linking of CD229 receptors with intact antibody inhibited CD229 internalization on B cells. However, when F(ab')(2) antibodies were used, CD229 internalization was similar on T and B cells, suggesting that Fcgamma receptors control CD229 cell surface expression. Furthermore, CD229 was regulated by T cell receptor and B cell receptor signaling because coligation with antibodies against anti-CD3 and anti-IgM increased the rate of CD229 endocytosis. These data suggest that CD229 cell surface expression on lymphocytes surface is strongly and differentially regulated within the CD150 family members.

  6. Retrospective analysis of 229 cases of neonatal in-hospital mortality%229例住院死亡新生儿回顾性分析

    Institute of Scientific and Technical Information of China (English)

    罗英; 杨辉; 戴怡蘅; 刘卫东

    2014-01-01

    目的:探讨住院新生儿死亡原因的变化,以提高新生儿疾病的诊治水平,指导防治重点。方法:对2009年1月至2012年9月的229例住院死亡新生儿以死亡第一诊断为死亡原因进行回顾性分析。结果:住院新生儿死亡率为2.39%,男婴高于女婴,死亡的新生儿多数为生后7d内的早期新生儿,导致新生儿死亡的主要死因为新生儿肺透明膜病、新生儿重度窒息、先天畸形、极早产儿、重症肺炎,产科相关因素为宫内感染、胎膜早破、不定期产检。结论:加强遗传咨询和针对性筛查,减少畸形的发生,定期产检,预防早产、窒息、感染,防止孕期及新生儿期并发症,有利于降低新生儿死亡率。%Objective: To explore the causes of in-hospital neonatal death for improving the diagnosis and treatment of neonatal diseases. Methods:229 cases of neonatal death from January 2009 to Septerment.2012 in our hospital were retrospectively analyzed, with the first diagnosis of death as the cause of death. Results:The in-hospital neonatal mortality was 2.39%. Neonatal mortality of male was higher than that of female. The majority of neonatal death occurred within 7 days after birth. Pulmonary hyaline membrane disease of newborn, severe neonatal asphyxia, congenital malformation,extremely of preterm infant, and severe pneumonia were the main causes of death for newborns, and intrauterine infection, premature rupture, without regular prenatal examination were main causes related with obstetrics. Conclusion:Enforceing the geneting counseling and targeted screening,to reduce deformities, taking regular antenatal examination, preventing premature birth, asphyxia, and infection, and avoiding the complications during pregnancy and neonatal period are effective measures reduce neonatal mortality.

  7. 20 CFR 229.52 - Age reduction when a reduced age O/M is effective before DIB O/M.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Age reduction when a reduced age O/M is effective before DIB O/M. 229.52 Section 229.52 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS... Minimum Rate § 229.52 Age reduction when a reduced age O/M is effective before DIB O/M. If an...

  8. Temporal proteomic profiling of Chlamydia trachomatis-infected HeLa-229 human cervical epithelial cells.

    Science.gov (United States)

    Tan, Grace Min Yi; Lim, Hui Jing; Yeow, Tee Cian; Movahed, Elaheh; Looi, Chung Yeng; Gupta, Rishein; Arulanandam, Bernard P; Abu Bakar, Sazaly; Sabet, Negar Shafiei; Chang, Li-Yen; Wong, Won Fen

    2016-05-01

    Chlamydia trachomatis is the leading causative agent of bacterial sexually transmitted infections worldwide which can lead to female pelvic inflammatory disease and infertility. A greater understanding of host response during chlamydial infection is essential to design intervention technique to reduce the increasing incidence rate of genital chlamydial infection. In this study, we investigated proteome changes in epithelial cells during C. trachomatis infection by using an isobaric tags for relative and absolute quantitation (iTRAQ) labeling technique coupled with a liquid chromatography-tandem mass spectrometry (LC-MS(3) ) analysis. C. trachomatis (serovar D, MOI 1)-infected HeLa-229 human cervical carcinoma epithelial cells (at 2, 4 and 8 h) showed profound modifications of proteome profile which involved 606 host proteins. MGST1, SUGP2 and ATXN10 were among the top in the list of the differentially upregulated protein. Through pathway analysis, we suggested the involvement of eukaryotic initiation factor 2 (eIF2) and mammalian target of rapamycin (mTOR) in host cells upon C. trachomatis infection. Network analysis underscored the participation of DNA repair mechanism during C. trachomatis infection. In summary, intense modifications of proteome profile in C. trachomatis-infected HeLa-229 cells indicate complex host-pathogen interactions at early phase of chlamydial infection.

  9. Enhanced effect of quark mass variation in 229Th and limits from Oklo data

    CERN Document Server

    Flambaum, V V

    2008-01-01

    The effects of the variation of the dimensionless strong interaction parameter Xq=mq/Lambda{QCD} (mq is the quark mass, Lambda{QCD} is the QCD scale) are enhanced about 1.5 x 10**5 times in the 7.6 eV "nuclear clock" transition between the ground and first excited states in the 229Th nucleus and about 1 x 10**8 times in the relative shift of the 0.1 eV compound resonance in 150Sm.The best terrestrial limit on the temporal variation of the fundamental constants, |delta(Xq)/Xq| < 4 x 10**-9 at 1.8 billion years ago (|d(Xq/Xq)/dt| < 2.2 x 10**-18 y**-1), is obtained from the shift of this Sm resonance derived from the Oklo natural nuclear reactor data. The results for 229Th and 150Sm are obtained by extrapolation from light nuclei where the many-body calculations can be performed more accurately. The errors produced by such extrapolation may be smaller than the errors of direct calculations in heavy nuclei. The extrapolation results are compared with the "direct" estimates obtained using the Walecka model....

  10. Broad-Line Reverberation in the Kepler-Field Seyfert Galaxy Zw 229-015

    CERN Document Server

    Barth, A J; Malkan, M A; Filippenko, A V; Li, W; Gorjian, V; Joner, M D; Bennert, V N; Botyanszki, J; Cenko, S B; Childress, M; Choi, J; Comerford, J M; Cucciara, A; da Silva, R; Duchene, G; Fumagalli, M; Ganeshalingam, M; Gates, E L; Gerke, B F; Griffith, C V; Harris, C; Hintz, E G; Hsiao, E; Kandrashoff, M T; Keel, W C; Kirkman, D; Kleiser, I K W; Laney, C D; Lee, J; Lopez, L; Lowe, T B; Moody, J W; Morton, A; Nierenberg, A M; Nugent, P; Pancoast, A; Rex, J; Rich, R M; Silverman, J M; Smith, G H; Sonnenfeld, A; Suzuki, N; Tytler, D; Walsh, J L; Woo, J -H; Yang, Y; Zeisse, C

    2011-01-01

    The Seyfert 1 galaxy Zw 229-015 is among the brightest active galaxies being monitored by the Kepler mission. In order to determine the black hole mass in Zw 229-015 from H-beta reverberation mapping, we have carried out nightly observations with the Kast Spectrograph at the Lick 3m telescope during the dark runs from June through December 2010, obtaining 54 spectroscopic observations in total. We have also obtained nightly V-band imaging with the Katzman Automatic Imaging Telescope at Lick Observatory and with the 0.9m telescope at the Brigham Young University West Mountain Observatory over the same period. We detect strong variability in the source, which exhibited more than a factor of 2 change in broad H-beta flux. From cross-correlation measurements, we find that the H-beta light curve has a rest-frame lag of 3.86(+0.69,-0.90) days with respect to the V-band continuum variations. We also measure reverberation lags for H-alpha and H-gamma and find an upper limit to the H-delta lag. Combining the H-beta la...

  11. Long-term chromospheric activity in southern M dwarfs: Gl 229 A and Gl 752 A

    CERN Document Server

    Buccino, Andrea P; Luoni, María Luisa; Mauas, Pablo J D

    2010-01-01

    Several late-type stars present activity cycles similar to that of the Sun. However, these cycles have been mostly studied in F to K stars. Due to their small intrinsic brightness, M dwarfs are not usually the targets of long-term observational studies of stellar activity, and their long-term variability is generally not known. In this work, we study the long-term activity of two M dwarf stars: Gl 229 A (M1/2) and Gl 752 A (M2.5). We employ medium resolution echelle spectra obtained at the 2.15 m telescope at the Argentinian observatory CASLEO between the years 2000 and 2010 and photometric observations obtained from the ASAS database. We analyzed Ca \\II K line-core fluxes and the mean V magnitude with the Lomb-Scargle periodogram, and we obtain possible activity cycles of $\\sim$4 yr and $\\sim$7 yr for Gl 229 A and Gl 752 A respectively.

  12. Characterization of the expression and immunogenicity of the ns4b protein of human coronavirus 229E

    DEFF Research Database (Denmark)

    Chagnon, F; Lamarre, A; Lachance, C;

    1998-01-01

    and immunogenicity of the ns4b gene product from strain 229E of human coronavirus (HCV-229E), a respiratory virus with a neurotropic potential. The gene was cloned and expressed in bacteria. A fusion protein of ns4b with maltose-binding protein was injected into rabbits to generate specific antibodies that were used...... to demonstrate the expression of ns4b in HCV-229E-infected cells using flow cytometry. Given a previously reported contiguous five amino acid shared region between ns4b and myelin basic protein, a purified recombinant histidine-tagged ns4b protein and (or) human myelin basic protein were injected into mice......Sequencing of complementary DNAs prepared from various coronaviruses has revealed open reading frames encoding putative proteins that are yet to be characterized and are so far only described as nonstructural (ns). As a first step in the elucidation of its function, we characterized the expression...

  13. Continuous-wave, single-frequency 229  nm laser source for laser cooling of cadmium atoms.

    Science.gov (United States)

    Kaneda, Yushi; Yarborough, J M; Merzlyak, Yevgeny; Yamaguchi, Atsushi; Hayashida, Keitaro; Ohmae, Noriaki; Katori, Hidetoshi

    2016-02-15

    Continuous-wave output at 229 nm for the application of laser cooling of Cd atoms was generated by the fourth harmonic using two successive second-harmonic generation stages. Employing a single-frequency optically pumped semiconductor laser as a fundamental source, 0.56 W of output at 229 nm was observed with a 10-mm long, Brewster-cut BBO crystal in an external cavity with 1.62 W of 458 nm input. Conversion efficiency from 458 nm to 229 nm was more than 34%. By applying a tapered amplifier (TA) as a fundamental source, we demonstrated magneto-optical trapping of all stable Cd isotopes including isotopes Cd111 and Cd113, which are applicable to optical lattice clocks.

  14. Temperature- and magnetic field-dependence of exchange bias in SrCoO2.29 ceramics

    Directory of Open Access Journals (Sweden)

    L. Xie

    2017-01-01

    Full Text Available A cation’s oxidation state in a transition metal oxide may significantly change its physical and chemical properties. In this work, magnetic properties of both cubic SrCoO2.29 and hexagonal SrCoO2.50 ceramics, annealed following a selected yet simple process, have been studied. The SrCoO2.50 ceramics annealed in air displays an unusual paramagnetic property, and the SrCoO2.29 quenched into water shows a short-range ferromagnetic coupling in the antiferromagnetic background. Exchange coupling at the ferromagnetic/antiferromagnetic interfaces brings out an obvious exchange bias effect in the SrCoO2.29 sample. Due to its complicated magnetic states, the exchange bias effect presents strong temperature and cooling field dependences.

  15. Improved Value for the Energy Splitting of the Ground-State Doublet in the Nucleus 229Th

    CERN Document Server

    Beck, B R; Beiersdorfer,1 P; Brown, G V; Moody, J K; Wu, C Y; Wilhelmy, J B; Porter, F S; Kilbourne, C A; Kelley, R L

    2010-01-01

    We have made an improved estimate of the 229mTh isomer energy. The new value 7.8(5) eV includes an estimate of spectral contamination due to the out-of-band E2 transition from the 42.43-keV 7/2+ member of the [633] ground state band to the 3/2+ [631] 229mTh bandhead. We estimate a 2% branching ratio for this unobserved transition in the 42.43-keV 7/2+ [633] deexcitation. The excitation of the 229mTh level is increased from the previously reported value of 7.6(5) eV to the new value of 7.8(5) eV when this branch is included in the analysis.

  16. Improved Value for the Energy Splitting of the Ground-State Doublet in the Nucleus 229mTh

    Energy Technology Data Exchange (ETDEWEB)

    Beck, B R; Wu, C; Beiersdorfer, P; Brown, G V; Becker, J A; Moody, K J; Wilhelmy, J B; Porter, F S; Kilbourne, C A; Kelley, R L

    2009-07-16

    We have made an improved estimate of the {sup 229m}Th isomer energy. The new value, 7.8(5) eV, includes an estimate of possible spectral contamination effects due to the out-of-band E2 transition from the 42.43-keV 7/2+ member of the [633] ground state band to the 3/2+ [631] {sup 229m}Th bandhead and so a weak and unresolved transition a few eV different in energy. We estimate a 2% branching ratio for this unobserved transition in the 42.43-keV 7/2+ [633] deexcitation. The excitation of the {sup 229m}Th level is increased from the previously reported value of 7.6(5) eV to the new best value of 7.8(5) eV when this branch is included in the analysis.

  17. Discovery of $^{229}$Rn and the structure of the heaviest Rn and Ra isotopes from Penning-trap mass measurements

    CERN Document Server

    Neidherr, D; Beck, D; Blaum, K; Böhm, Ch; Breitenfeldt, M; Cakirli, R B; Casten, R F; George, S; Herfurth, F; Herlert, A; Kellerbauer, A G; Kowalska, M; Lunney, D; Minaya-Ramirez, E; Naimi, S; Noah, E; Penescu, L; Rosenbusch, M; Schwarz, S; Schweikhard, L; Stora, T

    2009-01-01

    The masses of the neutron-rich radon isotopes $^{223–229}$Rn have been determined for the first time, using the ISOLTRAP setup at CERN ISOLDE. In addition, this experiment marks the first discovery of a new nuclide,$^{229}$Rn, by Penning-trap mass measurement. The new, high-accuracy data allow a fine examination of the mass surface, via the valence-nucleon interaction ${\\delta}$V$_{pn}$. The results reveal intriguing behavior, possibly reflecting either a N=134 subshell closure or an octupolar deformation in this region.

  18. Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials.

    Science.gov (United States)

    Warnes, Sarah L; Little, Zoë R; Keevil, C William

    2015-11-10

    The evolution of new and reemerging historic virulent strains of respiratory viruses from animal reservoirs is a significant threat to human health. Inefficient human-to-human transmission of zoonotic strains may initially limit the spread of transmission, but an infection may be contracted by touching contaminated surfaces. Enveloped viruses are often susceptible to environmental stresses, but the human coronaviruses responsible for severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) have recently caused increasing concern of contact transmission during outbreaks. We report here that pathogenic human coronavirus 229E remained infectious in a human lung cell culture model following at least 5 days of persistence on a range of common nonbiocidal surface materials, including polytetrafluoroethylene (Teflon; PTFE), polyvinyl chloride (PVC), ceramic tiles, glass, silicone rubber, and stainless steel. We have shown previously that noroviruses are destroyed on copper alloy surfaces. In this new study, human coronavirus 229E was rapidly inactivated on a range of copper alloys (within a few minutes for simulated fingertip contamination) and Cu/Zn brasses were very effective at lower copper concentration. Exposure to copper destroyed the viral genomes and irreversibly affected virus morphology, including disintegration of envelope and dispersal of surface spikes. Cu(I) and Cu(II) moieties were responsible for the inactivation, which was enhanced by reactive oxygen species generation on alloy surfaces, resulting in even faster inactivation than was seen with nonenveloped viruses on copper. Consequently, copper alloy surfaces could be employed in communal areas and at any mass gatherings to help reduce transmission of respiratory viruses from contaminated surfaces and protect the public health. Respiratory viruses are responsible for more deaths globally than any other infectious agent. Animal coronaviruses that "host jump" to humans result in

  19. Energy splitting of the ground-state doublet in the nucleus 229Th.

    Science.gov (United States)

    Beck, B R; Becker, J A; Beiersdorfer, P; Brown, G V; Moody, K J; Wilhelmy, J B; Porter, F S; Kilbourne, C A; Kelley, R L

    2007-04-01

    The energy splitting of the 229Th ground-state doublet is measured to be 7.6+/-0.5 eV, significantly greater than earlier measurements. Gamma rays produced following the alpha decay of 233U (105 muCi) were counted in the NASA/electron beam ion trap x-ray microcalorimeter spectrometer with an experimental energy resolution of 26 eV (FWHM). A difference technique was applied to the gamma-ray decay of the 71.82 keV level that populates both members of the doublet. A positive correction amounting to 0.6 eV was made for the unobserved interband decay of the 29.19 keV state (29.19-->0 keV).

  20. Energy Splitting of the Ground-State Doublet in the Nucleus Th229

    Science.gov (United States)

    Beck, B. R.; Becker, J. A.; Beiersdorfer, P.; Brown, G. V.; Moody, K. J.; Wilhelmy, J. B.; Porter, F. S.; Kilbourne, C. A.; Kelley, R. L.

    2007-04-01

    The energy splitting of the Th229 ground-state doublet is measured to be 7.6±0.5eV, significantly greater than earlier measurements. Gamma rays produced following the alpha decay of U233 (105μCi) were counted in the NASA/electron beam ion trap x-ray microcalorimeter spectrometer with an experimental energy resolution of 26 eV (FWHM). A difference technique was applied to the gamma-ray decay of the 71.82 keV level that populates both members of the doublet. A positive correction amounting to 0.6 eV was made for the unobserved interband decay of the 29.19 keV state (29.19→0keV).

  1. Kinematics and duty cycles of the SM-229 force-reflecting servomanipulator

    Energy Technology Data Exchange (ETDEWEB)

    Stoughton, R.S.

    1986-02-01

    This report describes the first known experimental study of servomanipulator duty cycles to appear in the literature. The servomanipulator used was TeleOperator Systems Model SM-229. The experimental approach used was to record the joint positions and motor currents of the right slave arm at a rate of 10 Hz over about 50 h of typical remote manipulation operations. The results are presented as position usage patterns in joint and real-world coordinates, time-use histograms of joint velocities and motor currents, and three-dimensional mechanical power histograms for each joint. All results are presented in dimensionless form, scaled to the design ranges of the manipulator and the total operation time recorded. Applications of this study include improvements in kinematic ranges, gear reductions, motor sizings, drive configurations, and stress relief. Included in appendices are an uncertainty analysis, calibration procedures, and analysis of the kinematics of the manipulator. 12 refs., 42 figs., 15 tabs.

  2. Direct two-photon excitation of isomeric transition in thorium-229 nucleus

    CERN Document Server

    Romanenko, V I; Yatsenko, L P; Romanenko, A V; Litvinov, A N; Kazakov, G A

    2012-01-01

    A possibility of the two-photon excitation of an isomeric state in a nucleus of thorium-229 has been discussed. The fluorescence intensity of the excitation is demonstrated to be identical for the irradiation of nuclei with either monochromatic light or polychromatic radiation consisting of a sequence of short light pulses of the same intensity. The two-photon excitation of Th^{3+} ion in an electromagnetic trap with a focused laser beam with a wavelength of about 320 nm and power of 100 mW can lead to the absorption saturation, at which the fluorescence emission with the frequency of the transition in a nucleus is maximal. In crystals doped with Th^{4+} to a concentration of about 10^{18} cm^{-3} and irradiated with a laser radiation 10 W in power, the emission of several photons per second with a wavelength of about 160 nm becomes possible.

  3. CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse

    NARCIS (Netherlands)

    Romero, [No Value; Zapater, N; Calvo, M; Kalko, SG; de la Fuente, MA; Tovar, [No Value; Ockeloen, C; Pizcueta, P; Engel, P

    2005-01-01

    CD229 is a member of the CD150 family of the Ig superfamily expressed on T and B cells. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells. The cytoplasmic tail of CD229 binds to SAP, a protein that is defective in X-linked lymphoproliferative syndrome

  4. CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse

    NARCIS (Netherlands)

    Romero, [No Value; Zapater, N; Calvo, M; Kalko, SG; de la Fuente, MA; Tovar, [No Value; Ockeloen, C; Pizcueta, P; Engel, P

    2005-01-01

    CD229 is a member of the CD150 family of the Ig superfamily expressed on T and B cells. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells. The cytoplasmic tail of CD229 binds to SAP, a protein that is defective in X-linked lymphoproliferative syndrome

  5. 12 CFR 609.910 - Compliance with the Electronic Signatures in Global and National Commerce Act (Public Law 106-229...

    Science.gov (United States)

    2010-01-01

    ... Global and National Commerce Act (Public Law 106-229) (E-SIGN). 609.910 Section 609.910 Banks and Banking... with the Electronic Signatures in Global and National Commerce Act (Public Law 106-229) (E-SIGN). (a) General. E-SIGN makes it easier to conduct E-commerce. With some exceptions, E-SIGN permits the use and...

  6. Enhanced effect of quark mass variation in Th229 and limits from Oklo data

    Science.gov (United States)

    Flambaum, V. V.; Wiringa, R. B.

    2009-03-01

    The effects of the variation of the dimensionless strong interaction parameter Xq=mq/ΛQCD (mq is the quark mass, ΛQCD is the QCD scale) are enhanced about 1.5×105 times in the 7.6 eV “nuclear clock” transition between the ground and first excited states in the Th229 nucleus and about 1×108 times in the relative shift of the 0.1 eV compound resonance in Sm150. The best terrestrial limit on the temporal variation of the fundamental constants, |δXq/Xq|Oklo natural nuclear reactor data. The results for Th229 and Sm150 are obtained by extrapolation from light nuclei where the many-body calculations can be performed more accurately. The errors produced by such extrapolation may be smaller than the errors of direct calculations in heavy nuclei. The extrapolation results are compared with the “direct” estimates obtained using the Walecka model. A number of numerical relations needed for the calculations of the variation effects in nuclear physics and atomic spectroscopy have been obtained: for the nuclear binding energy δE/E≈-1.45δmq/mq, for the spin-orbit intervals δEso/Eso≈-0.22δmq/mq, for the nuclear radius δr/r≈0.3δmq/mq (in units of ΛQCD); for the shifts of nuclear resonances and weakly bound energy levels δEr≈10δXq/Xq MeV.

  7. A VUV detection system for the direct photonic identification of the first excited isomeric state of $^{229}$Th

    CERN Document Server

    Seiferle, Benedict; Laatiaoui, Mustapha; Thirolf, Peter G

    2015-01-01

    With an expected energy of 7.6(5) eV, $^{229}$Th possesses the lowest excited nuclear state in the landscape of all presently known nuclei. The energy corresponds to a wavelength of about 160 nm and would conceptually allow for an optical laser excitation of a nuclear transition. We report on a VUV optical detection system that was designed for the direct detection of the isomeric ground-state transition of $^{229}$Th. $^{229(m)}$Th ions originating from a $^{233}$U $\\alpha$-recoil source are collected on a micro electrode that is placed in the focus of an annular parabolic mirror. The latter is used to parallelize the UV fluorescence that may emerge from the isomeric ground-state transition of $^{229}$Th. The parallelized light is then focused by a second annular parabolic mirror onto a CsI-coated position-sensitive MCP detector behind the mirror exit. To achieve a high signal-to-background ratio, a small spot size on the MCP detector needs to be achieved. Besides extensive ray-tracing simulations of the opt...

  8. 17 CFR 229.303 - (Item 303) Management's discussion and analysis of financial condition and results of operations.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 303) Management's... 1975-REGULATION S-K Financial Information § 229.303 (Item 303) Management's discussion and analysis of..., changes in financial condition and results of operations. Discussions of liquidity and capital resources...

  9. 4' and 24' Shock Tubes - Electric Arc Shock Tube Facililty N-229 (East) The facility is used to

    Science.gov (United States)

    1978-01-01

    4' and 24' Shock Tubes - Electric Arc Shock Tube Facililty N-229 (East) The facility is used to investigate the effects of radiation and ionization during outer planetary entries as well as for air-blast simualtion which requires the strongest possible shock generation in air at loadings of 1 atm or greater.

  10. 17 CFR 229.1013 - (Item 1013) Purposes, alternatives, reasons and effects in a going-private transaction.

    Science.gov (United States)

    2010-04-01

    ...-REGULATION S-K Mergers and Acquisitions (Regulation M-A) § 229.1013 (Item 1013) Purposes, alternatives... transaction. (b) Alternatives. If the subject company or affiliate considered alternative means to accomplish... company, its affiliates and unaffiliated security holders, including the federal tax consequences of...

  11. 12 CFR Appendix A to Part 229 - Routing Number Guide to Next-Day Availability Checks and Local Checks

    Science.gov (United States)

    2010-01-01

    ... Checks and Local Checks A Appendix A to Part 229 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED... Association. The routing number takes two forms: a fractional form and a nine-digit form. A paying bank... bank. B. The first four digits of the nine-digit routing number (and the denominator of the fractional...

  12. 17 CFR 229.1114 - (Item 1114) Credit enhancement and other support, except for certain derivatives instruments.

    Science.gov (United States)

    2010-04-01

    ...-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1114 (Item 1114) Credit enhancement and other... to affect or ensure timely payment of the asset-backed securities: (1) Any external credit enhancement designed to ensure that the asset-backed securities or pool assets will pay in accordance with...

  13. 17 CFR 229.501 - (Item 501) Forepart of Registration Statement and Outside Front Cover Page of Prospectus.

    Science.gov (United States)

    2010-04-01

    .... Instruction to Item 501: For asset-backed securities, see also Item 1102 of Regulation AB (§ 229.1102). ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 501) Forepart of... Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD INSTRUCTIONS FOR FILING FORMS UNDER...

  14. 17 CFR 229.1102 - (Item 1102) Forepart of registration statement and outside cover page of the prospectus.

    Science.gov (United States)

    2010-04-01

    ...-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1102 (Item 1102) Forepart of registration... applicable, and the first expected distribution date for the asset-backed securities. (h) Briefly describe... designations of the securities offered. (c) Identify the asset type(s) being securitized. (d) Include a...

  15. A VUV detection system for the direct identification of the fluorescence radiation of {sup 229m}Th

    Energy Technology Data Exchange (ETDEWEB)

    Seiferle, Benedict; Wense, Lars v.d.; Thirolf, Peter G. [LMU Munich (Germany)

    2015-07-01

    In the whole landscape of atomic nuclei, {sup 229}Th has the lowest transition energy to its first excited state. The transition energy was indirectly measured to be 7.8(5) eV, which corresponds to ∼160 nm and conceptionally allows to get optical access to the transition. This talk reports on a VUV detection system that aims on the direct detection of the fluorescence radiation of {sup 229m}Th. The setup consists of two annular parabolic mirrors (made of MgF{sub 2}-coated aluminum) and a phosphorous screen behind a CsI-coated MCP, monitored by a CCD camera. {sup 229(m)}Th will be populated via the α decay of {sup 233}U. Therefore a {sup 233}U α-recoil source is placed in a buffer-gas stopping cell, where a continuous ion beam is produced by a subsequent RFQ. By using a quadrupole mass separator, {sup 229(m)}Th ions are then separated from other short lived daughter nuclei. The {sup 229(m)}Th ions are collected on a point-like micro electrode (50 μm in diameter) that is placed in the focal spot of the annular parabolic mirror (f=10 mm) which collimates the fluorescence radiation. The parallelized light is then focused by a second annular parabolic mirror (f=2 mm) onto the MCP. To get a high signal to noise ratio, it is important to achieve a small focal spot size on the MCP. Since the optical axis is blocked by the collection electrode, also the alignment of the optics poses a special challenge. The alignment method as well as results from first test measurements will be presented.

  16. Enhanced effect of quark mass variation in {sup229}Th and limits from Oklo data.

    Energy Technology Data Exchange (ETDEWEB)

    Flambaum, V. V.; Wiringa, R. B.; Physics; Univ. of New South Wales; Perimeter Inst. for Theoretical Physics

    2009-01-01

    The effects of the variation of the dimensionless strong interaction parameter X{sub q} = m{sub q}/{Lambda}{sub QCD} (m{sub q} is the quark mass, {Lambda}{sub QCD} is the QCD scale) are enhanced about 1.5 x 10{sup 5} times in the 7.6 eV 'nuclear clock' transition between the ground and first excited states in the {sup 229}Th nucleus and about 1 x 10{sup 8} times in the relative shift of the 0.1 eV compound resonance in {sup 150}Sm. The best terrestrial limit on the temporal variation of the fundamental constants, |{delta}X{sub q}/X{sub q}| < 4 x 10{sup -9} at 1.8 billion years ago (|X{sub q}/X{sub q}| < 2.2 x 10{sup -18}y{sup -1}), is obtained from the shift of this Sm resonance derived from the Oklo natural nuclear reactor data. The results for {sup 229}Th and {sup 150}Sm are obtained by extrapolation from light nuclei where the many-body calculations can be performed more accurately. The errors produced by such extrapolation may be smaller than the errors of direct calculations in heavy nuclei. The extrapolation results are compared with the 'direct' estimates obtained using the Walecka model. A number of numerical relations needed for the calculations of the variation effects in nuclear physics and atomic spectroscopy have been obtained: for the nuclear binding energy {delta} E/E {approx} -1.45 {delta}m{sub q}/m{sub q}, for the spin-orbit intervals {delta}E{sub so}/E{sub so} {approx} -0.22 {delta}m{sub q}/m{sub q}, for the nuclear radius {delta}r/r {approx} 0.3 {delta}m{sub q}/m{sub q} (in units of {Lambda}{sub QCD}); for the shifts of nuclear resonances and weakly bound energy levels {delta}E{sub r} {approx} 10 {delta}X{sub q}/X{sub q} MeV.

  17. Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas

    Directory of Open Access Journals (Sweden)

    Marta Mellai

    2013-01-01

    Full Text Available The epithelial membrane protein 3 (EMP3 is a candidate tumor suppressor gene in the critical region 19q13.3 for several solid tumors, including tumors of the nervous systems. The aim of this study was to investigate the EMP3 promoter hypermethylation status in a series of 229 astrocytic and oligodendroglial tumors and in 16 GBM cell lines. The analysis was performed by methylation-specific PCR and capillary electrophoresis. Furthermore, the EMP3 expression at protein level was evaluated by immunohistochemistry and Western blotting analysis. Associations of EMP3 hypermethylation with total 1p/19q codeletion, MGMT promoter hypermethylation, IDH1/IDH2 and TP53 mutations, and EGFR amplification were studied, as well as its prognostic significance. The EMP3 promoter hypermethylation has been found in 39.5% of gliomas. It prevailed in low-grade tumors, especially in gliomas with an oligodendroglial component, and in sGBMs upon pGBMs. In oligodendroglial tumors, it was strongly associated with both IDH1/IDH2 mutations and total 1p/19q codeletion and inversely with EGFR gene amplification. No association was found with MGMT hypermethylation and TP53 mutations. In the whole series, the EMP3 hypermethylation status correlated with 19q13.3 loss and lack of EMP3 expression at protein level. A favorable prognostic significance on overall survival of the EMP3 promoter hypermethylation was found in patients with oligodendroglial tumors.

  18. Prospects for measuring the $^{229}$Th isomer energy using a metallic magnetic microcalorimeter

    CERN Document Server

    Kazakov, G A; Sterba, J H; Fleischmann, A; Enss, C; Schumm, T

    2013-01-01

    The Thorium-229 isotope features a nuclear isomer state with extremely low energy. The currently most accepted energy value, $7.8 \\pm 0.5$\\,eV, was obtained from an indirect measurements using a NASA x-ray microcalorimeter with instrumental resolution (FWHM) of 26\\,eV. We study, how state-of-the-art magnetic metallic microcalorimeters with an energy resolution down to a few eV can be used to measure the isomer energy. Resolving the 29.18\\,keV doublet in the $\\gamma$-spectrum following the $\\alpha$-decay of Uranium-233, corresponding to the decay into the ground and isomer state, allows to measure the isomer transition energy without additional theoretical input parameters and increase the energy accuracy. We study the dependence of the attainable precision of this measurement on the signal and background count rates and the instrumental energy resolution. Assuming realistic experimental parameters corresponding to the currently available detector technology, we show that such a measurement is highly feasable.

  19. Nuclear structure of229Th from γ-ray spectroscopy study of233U α-particle decay

    Science.gov (United States)

    Barci, V.; Ardisson, G.; Barci-Funel, G.; Weiss, B.; El Samad, O.; Sheline, R. K.

    2003-09-01

    The level structure of 229Th, produced by α-particle decay of 233U, was studied with γ-ray spectroscopy measurements. The sources were continuously separated from daughters with ion-exchange chromatographic methods. Singles and coincidence measurements were performed with high-purity germanium detectors. Energies and intensities of about 220 γ rays were accurately determined. About 70 transitions were reported for the first time, especially in the 300 700 keV energy range. A 229Th level scheme was proposed, accounting for 220 transitions among 47 excited states. Alpha-particle feeding intensities and hindrance factors were deduced and compared to direct α-particle measurements; the agreement was found to be relatively good. The level structure was interpreted in the framework of rotational and/or reflection asymmetric models. The agreement with experimental data was shown to be satisfactory.

  20. Results of a direct search using synchrotron radiation for the low-energy $^{229}$Th nuclear isomeric transition

    CERN Document Server

    Jeet, Justin; Sullivan, Scott T; Rellergert, Wade G; Mirzadeh, Saed; Cassanho, A; Jenssen, H P; Tkalya, Eugene V; Hudson, Eric R

    2015-01-01

    We report the results of a direct search for the $^{229}$Th ($I^{p} = 3/2^+\\leftarrow 5/2^+$) nuclear isomeric transition, performed by exposing $^{229}$Th-doped LiSrAlF$_6$ crystals to tunable vacuum-ultraviolet synchrotron radiation and observing any resulting fluorescence. We also use existing nuclear physics data to establish a range of possible transition strengths for the isomeric transition. We find no evidence for the thorium nuclear transition between $7.3 \\mbox{eV}$ and $8.8 \\mbox{eV}$ with transition lifetime $(1-2)\\mbox{s} \\lesssim \\tau \\lesssim (2000-5600)\\mbox{s}$. This measurement excludes roughly half of the favored transition search area and can be used to direct future searches.

  1. Results of a Direct Search Using Synchrotron Radiation for the Low-Energy (229)Th Nuclear Isomeric Transition.

    Science.gov (United States)

    Jeet, Justin; Schneider, Christian; Sullivan, Scott T; Rellergert, Wade G; Mirzadeh, Saed; Cassanho, A; Jenssen, H P; Tkalya, Eugene V; Hudson, Eric R

    2015-06-26

    We report the results of a direct search for the (229)Th (I(π)=3/2(+)←5/2(+)) nuclear isomeric transition, performed by exposing (229)Th-doped LiSrAlF(6) crystals to tunable vacuum-ultraviolet synchrotron radiation and observing any resulting fluorescence. We also use existing nuclear physics data to establish a range of possible transition strengths for the isomeric transition. We find no evidence for the thorium nuclear transition between 7.3 eV and 8.8 eV with transition lifetime (1-2) s≲τ≲(2000-5600)  s. This measurement excludes roughly half of the favored transition search area and can be used to direct future searches.

  2. Characteristics of mass and nuclear charge distributions of sup 229 Th(n sub th ,f). Implications for fission dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Bocquet, J.P.; Faust, H.R. (Institut Max von Laue - Paul Langevin, 38 - Grenoble (France)); Brissot, R. (Grenoble-1 Univ., 38 (France). Inst. des Sciences Nucleaires); Fowler, M.; Wilhelmy, J. (Los Alamos National Lab. (LANL), NM (USA). Isotope and Nuclear Chemistry Div.); Asghar, M.; Djebara, M. (Universite des Sciences et de la Technologie Houari Boumedienne, Algiers (Algeria))

    1990-01-01

    The mass and nuclear charge distributions of fission fragments from {sup 229}Th(n{sub th},f) have been measured at several kinetic energies with the mass spectrometer Lohengrin (ILL-Grenoble). The average proton e-o effect, which reaches 41%, induces large oscillations in the parameters of the isotopic charge distribution. A comparison of the data from different fissile nuclei shows the importance of the last stage of the process for intrinsic excitations. (orig.).

  3. Thorium silicate compound as a solid-state target for production of isomeric thorium-229 nuclei by electron beam irradiation

    Science.gov (United States)

    Borisyuk, P. V.; Vasilyev, O. S.; Lebedinskii, Y. Y.; Krasavin, A. V.; Tkalya, E. V.; Troyan, V. I.; Habibulina, R. F.; Chubunova, E. V.; Yakovlev, V. P.

    2016-09-01

    In this paper, we discuss an idea of the experiment for excitation of the isomeric transition in thorium-229 nuclei by irradiating with electron beam targets with necessary physical characteristics. The chemical composition and bandgap of ThSi10O22 were determined by X-ray photoelectron spectroscopy and reflection electron energy loss spectroscopy. It was found that the energy gap is equal to 7.7 eV and does not change when the target is exposed to a medium energy electron beam for a long time. This indicates that the compound possesses high electron-beam resistance. A quantitative estimation of the output function of isomeric thorium-229 nuclei generated by interaction of nuclei with the secondary electron flow formed by irradiating the solid-state ThSi10O22-based target is given. The estimation shows that ThSi10O22 is a promising thorium-containing target for investigating excitation of the nuclear low-lying isomeric transition in the thorium-229 isotope using medium-energy electrons.

  4. Thorium silicate compound as a solid-state target for production of isomeric thorium-229 nuclei by electron beam irradiation

    Directory of Open Access Journals (Sweden)

    P. V. Borisyuk

    2016-09-01

    Full Text Available In this paper, we discuss an idea of the experiment for excitation of the isomeric transition in thorium-229 nuclei by irradiating with electron beam targets with necessary physical characteristics. The chemical composition and bandgap of ThSi10O22 were determined by X-ray photoelectron spectroscopy and reflection electron energy loss spectroscopy. It was found that the energy gap is equal to 7.7 eV and does not change when the target is exposed to a medium energy electron beam for a long time. This indicates that the compound possesses high electron-beam resistance. A quantitative estimation of the output function of isomeric thorium-229 nuclei generated by interaction of nuclei with the secondary electron flow formed by irradiating the solid-state ThSi10O22-based target is given. The estimation shows that ThSi10O22 is a promising thorium-containing target for investigating excitation of the nuclear low-lying isomeric transition in the thorium-229 isotope using medium-energy electrons.

  5. ANTI-B-CELL THERAPY AT IMMUNE INFLAMMATORY RHEUMATIC DISEASES: EFFICACY AND TOLERABILITY IN 229 PATIENTS

    Directory of Open Access Journals (Sweden)

    L. P. Ananieva

    2014-01-01

    Full Text Available Objective: to assess the efficacy and tolerability of Rituximab treatment in patients with serious immune inflammatory rheumatic diseases (IRD like systemic lupus erythematosus (SLE, systemic sclerosis (SS, systemic vasculitis (SV, Sjogren syndrome (SjS, dermatomyositis/polymyositis (DM/PM.Subjects and methods. The clinical efficacy has been analyzed in 229 patients with IRD: SLE (n=97, SV (n=50, SS (n=40, SjS (n=23 and DM/PM (n=19. Rituximab treatment was accompanied by administration of glucocorticoids and/or immunosuppressive drugs. Most patients demonstrated resistance to or low tolerability of standard therapy. Efficacy of treatment was analyzed in each group with the criteria relevant for each disease. To compare clinical response to the treatment between the groups we used gradations accepted by international registries: complete (good response, partial response, no response. Average duration of monitoring comprised 72 (1–288 weeks after the first introduction of Rituximab. Average Rituximab dose administered to patients over the period of monitoring was low and varied from 1.6±0.84 in DM/PM to 3.1±1.75 in SV. About 80% of patients received one or two courses of Rituximab except for patients with SS (half of them received three and more courses.Results. «Complete response» was observed in 50.6%, «partial response» – in 35% of patients. Rituximab courses provided positive dynamics in clinical scores and allowed to reduce supportive dose of glucocorticoids and to lower the dose or withdraw of immune-stimulating drugs. Multiple Rituximab courses provided stable and longlasting effect. Recurrences were observed less frequently, whereas efficacy of the therapy increased during a year and longer. Occurrence of adverse events and mortality rate were comparable to data of other national Rituximab registries.Conclusion. The results of the study may prove administration of Rituximab in patients with resistance to standard

  6. Human Ly9 (CD229) as novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (B-CLL) recognized by autologous CD8+ T cells.

    Science.gov (United States)

    Bund, Dagmar; Mayr, Christine; Kofler, David M; Hallek, Michael; Wendtner, Clemens-Martin

    2006-07-01

    CD229, a cell-surface molecule being involved in cell adhesion, is overexpressed in B-CLL cells. In this study we wanted to explore whether CD229 might function as B-CLL-specific tumor-associated antigen (TAA). Autologous, CD229-specific HLA-A2-restricted T cells were identified using IFN-gamma-ELISPOT assays and HLA-A2/dimer-peptide staining after 4 weeks of in vitro culture. We were able to expand autologous T cells from 9/11 B-CLL patients using native B-CLL cells as antigen presenting cells (APCs) in 5 cases, whereas for 4 samples an autologous T-cell response could only be evoked by use of CD40L-stimulated B-CLL cells as APCs. The number of CD8+ T cells could be expanded during 4 weeks of in vitro culture with native or CD40L-activated B-CLL cells while the amount of specific T cells recognizing CD229 peptides bound to HLA-A2 dimers increased on average 12-fold (native CLL) and 13-fold (CD40L-activated CLL), respectively. Using IFN-gamma-ELISPOT assays we could demonstrate that the expanded T cells were able to secrete IFN-gamma upon recognition of the antigen. These T cells not only recognized HLA-A0201-binding CD229-derived peptides presented by T2 cells, but also CD229-overexpressing autologous B-CLL cells in an MHC-I-restricted manner. In summary, CD229 was shown to be naturally processed and presented as TAA in primary B-CLL cells, enabling the expansion of autologous tumor-specific T cells.

  7. CD229 is expressed on the surface of plasma cells carrying an aberrant phenotype and chemotherapy-resistant precursor cells in multiple myeloma.

    Science.gov (United States)

    Yousef, Sara; Kovacsovics-Bankowski, Magdalena; Salama, Mohamed E; Bhardwaj, Neelam; Steinbach, Mary; Langemo, Amanda; Kovacsovics, Tibor; Marvin, James; Binder, Mascha; Panse, Jens; Kröger, Nicolaus; Luetkens, Tim; Atanackovic, Djordje

    2015-01-01

    Multiple Myeloma (MM) is a plasma cell (PC) malignancy, which despite significant therapeutic advances, is still considered incurable. This is due to the persistence of chemotherapy-resistant minimal residual disease in the patients' bone marrow (BM) after an effective induction therapy. Immunotherapies targeting surface molecules expressed on the bulk of tumor cells and the chemotherapy-resistant, myeloma-propagating cells could play a central role in this clinical setting. We recently described surface molecule CD229 as a potential therapeutic target for MM. In our current study we assessed the expression of CD229 on different PC subtypes and on cells with a myeloma-propagating phenotype in a total of 77 patients with PC dyscrasias independently at 2 different cancer centers. We found that CD229 was strongly and homogeneously overexpressed on the PC of patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, MM, and PC leukemia. CD229 was particularly overexpressed on those PC showing an abnormal phenotype such as expression of CD56. Most importantly, CD229 was also highly expressed on those cells in the patients' BM displaying the phenotype of chemotherapy-resistant and myeloma-propagating cells. In conclusion, our combined findings suggest that immunotherapies targeting CD229 will not only be effective for the bulk of tumor cells but will also help to eradicate chemotherapy-resistant cells remaining in the patients' BM after induction treatment. Hopefully, the design of CD229-specific monoclonal antibodies or chimeric antigen receptor-transduced T cells will help to achieve prolonged remissions or even cures in MM patients.

  8. Reflection-asymmetric structures in 225Ra from γ-ray spectroscopy study of 229Th α decay

    Science.gov (United States)

    Gasparro, J.; Ardisson, G.; Barci, V.; Sheline, R. K.

    2000-12-01

    The level structure of 225Ra, produced in α decay of 229Th, was studied by γ-ray spectroscopy. The sources were continuously purified from daughters with ion-exchange chromatographic separation methods. Energies and intensities of 174 γ rays were accurately measured with HPGe detectors. About 100 γ rays were reported for the first time, especially in the 300-700 keV energy range. A 225Ra level scheme was proposed, accounting for about 200 transitions among 45 excited states. The level structure was interpreted in the framework of reflection-asymmetric structures with parity doublet bands. The model was shown to be in satisfactory agreement with experimental data.

  9. 小行星、慧星、流星IAU第229次会议文集

    Institute of Scientific and Technical Information of China (English)

    沈良照

    2008-01-01

    本书是2005年8月7~12日在巴西里约热内卢州Buzios举行的国内天文学联合会(ZAU,International Astronomical Umion)第229次学术讨论会的会议录,发表了除一篇外其他所有的邀请报告全文。提交到这一讨论会上的论文共有近400篇,待发表在Earth,Moon and Planets月刊的某期专刊中。

  10. The influence of binarity on dust obscuration events in the planetary nebula M 2-29 and its analogues

    CERN Document Server

    Miszalski, B; Köppen, J; Rauch, T; Acker, A; Cohen, M; Frew, D J; Moffat, A F J; Parker, Q A; Jones, A F; Udalski, A

    2011-01-01

    The central star of the planetary nebula (CSPN) M 2-29 shows an extraordinary R Coronae Borealis-like fading event in its optical lightcurve. The only other CSPN to show these events are CPD-568032 (Hen 3-1333) and V651 Mon (NGC 2346). Dust cloud formation in the line of sight appears responsible but the exact triggering mechanism is not well understood. Understanding how planetary nebulae (PNe) trigger dust obscuration events may help understand the same process in a wide range of objects including Population-I WC9 stars, symbiotic stars and perhaps Asymptotic Giant Branch (AGB) stars with long secondary periods (LSPs). A binary scenario involving an eccentric, wide companion that triggers dust formation via interaction at periastron is a potential explanation that has been suggested for LSP variables. Model fits to the lightcurves of CPD-568032 and M 2-29 show the dust forms in excess of 70 AU at the inner edge of a dust disk. In the case of CPD-568032 this radius is far too large to coincide with a binary ...

  11. Diversity and Evolutionary Histories of Human Coronaviruses NL63 and 229E Associated with Acute Upper Respiratory Tract Symptoms in Kuala Lumpur, Malaysia.

    Science.gov (United States)

    Al-Khannaq, Maryam Nabiel; Ng, Kim Tien; Oong, Xiang Yong; Pang, Yong Kek; Takebe, Yutaka; Chook, Jack Bee; Hanafi, Nik Sherina; Kamarulzaman, Adeeba; Tee, Kok Keng

    2016-05-04

    The human alphacoronaviruses HCoV-NL63 and HCoV-229E are commonly associated with upper respiratory tract infections (URTI). Information on their molecular epidemiology and evolutionary dynamics in the tropical region of southeast Asia however is limited. Here, we analyzed the phylogenetic, temporal distribution, population history, and clinical manifestations among patients infected with HCoV-NL63 and HCoV-229E. Nasopharyngeal swabs were collected from 2,060 consenting adults presented with acute URTI symptoms in Kuala Lumpur, Malaysia, between 2012 and 2013. The presence of HCoV-NL63 and HCoV-229E was detected using multiplex polymerase chain reaction (PCR). The spike glycoprotein, nucleocapsid, and 1a genes were sequenced for phylogenetic reconstruction and Bayesian coalescent inference. A total of 68/2,060 (3.3%) subjects were positive for human alphacoronavirus; HCoV-NL63 and HCoV-229E were detected in 45 (2.2%) and 23 (1.1%) patients, respectively. A peak in the number of HCoV-NL63 infections was recorded between June and October 2012. Phylogenetic inference revealed that 62.8% of HCoV-NL63 infections belonged to genotype B, 37.2% was genotype C, while all HCoV-229E sequences were clustered within group 4. Molecular dating analysis indicated that the origin of HCoV-NL63 was dated to 1921, before it diverged into genotype A (1975), genotype B (1996), and genotype C (2003). The root of the HCoV-229E tree was dated to 1955, before it diverged into groups 1-4 between the 1970s and 1990s. The study described the seasonality, molecular diversity, and evolutionary dynamics of human alphacoronavirus infections in a tropical region. © The American Society of Tropical Medicine and Hygiene.

  12. Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229, impairs cytokine production.

    Science.gov (United States)

    Engel, Pablo; Pérez-Carmona, Natàlia; Albà, M Mar; Robertson, Kevin; Ghazal, Peter; Angulo, Ana

    2011-10-01

    Human cytomegalovirus (HCMV), the β-herpesvirus prototype, has evolved a wide spectrum of mechanisms to counteract host immunity. Among them, HCMV uses cellular captured genes encoding molecules capable of interfering with the original host function or of fulfilling new immunomodulatory tasks. Here, we report on UL7, a novel HCMV heavily glycosylated transmembrane protein, containing an Ig-like domain that exhibits remarkable amino acid similarity to CD229, a cell-surface molecule of the signalling lymphocyte-activation molecule (SLAM) family involved in leukocyte activation. The UL7 Ig-like domain, which is well-preserved in all HCMV strains, structurally resembles the SLAM-family N-terminal Ig-variable domain responsible for the homophilic and heterophilic interactions that trigger signalling. UL7 is transcribed with early-late kinetics during the lytic infectious cycle. Using a mAb generated against the viral protein, we show that it is constitutively shed, through its mucine-like stalk, from the cell-surface. Production of soluble UL7 is enhanced by PMA and reduced by a broad-spectrum metalloproteinase inhibitor. Although UL7 does not hold the ability to interact with CD229 or other SLAM-family members, it shares with them the capacity to mediate adhesion to leukocytes, specifically to monocyte-derived DCs. Furthermore, we demonstrate that UL7 expression attenuates the production of proinflammatory cytokines TNF, IL-8 and IL-6 in DCs and myeloid cell lines. Thus, the ability of UL7 to interfere with cellular proinflammatory responses may contribute to viral persistence. These results enhance our understanding of those HCMV-encoded molecules involved in sustaining the balance between HCMV and the host immune system.

  13. A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation.

    Science.gov (United States)

    Margraf, Stefanie; Garner, Lee I; Wilson, Timothy J; Brown, Marion H

    2015-11-01

    Signalling lymphocyte activation molecule (SLAM) family members regulate activation and inhibition in the innate and adaptive immune systems. Genome-wide association studies identified their genetic locus (1q23) as highly polymorphic and associated with susceptibility to systemic lupus erythematosus (SLE). Here we show that the Val602 variant of the non-synonymous single nucleotide polymorphism (SNP) rs509749 in the SLAM family member CD229 (Ly9, SLAMF3) has a two-fold lower affinity compared with the SLE-associated Met602 variant for the small adaptor protein SAP. Comparison of the two variants in T-cell lines revealed the Val602 variant to be significantly more highly expressed than CD229 Met602 . Activation was diminished in cells expressing CD229 Val602 compared with CD229 Met602 as measured by up-regulation of CD69. There was no correlation between homozygosity at rs509749 and activation in peripheral blood mononuclear cells from healthy donors. These findings identify potential mechanisms by which a single SNP can perturb fine-tuning in the immune system with significant functional consequences. © 2015 The Authors. Immunology Published by John Wiley & Sons Ltd.

  14. Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4).

    Science.gov (United States)

    Romero, X; Benítez, D; March, S; Vilella, R; Miralpeix, M; Engel, P

    2004-08-01

    The CD150 (SLAM) family consists of nine leukocyte cell-surface proteins involved in lymphocyte activation that belong to the immunoglobulin (Ig) superfamily. Six members of this family--CD84, CD150 (SLAM), CD229 (Ly9), CD244 (2B4), NTB-A, and CS1--associate with adapter proteins--SLAM-associated protein (SAP) and EAT-2. SAP is a short intracellular molecule that is mutated in humans with X-linked lymphoproliferative disease. Flow cytometric analysis of the expression of CD84, CD150, CD229, and CD244 cell-surface receptors on several leukocyte and lymphocyte subsets was performed. CD84 and CD150 were present on thymocytes, mature T cells and antigen-presenting cells. The expression of CD84 and CD150 was high on memory T cells. CD150 expression was strongly up-regulated after cell activation. In contrast to CD84, CD150 was absent on resting monocytes and immature dendritic cells (DCs). CD229 presented a pattern of expression restricted to lymphocytes. CD244 was preferentially expressed on natural killer cells, CD8(+) effector cells, resting monocytes, basophils, and eosinophils. We describe a broader distribution of CD84, CD150, CD229, and CD244 than previously reported and show that they are differentially expressed on hematopoietic cells. The heterogeneous expression of these receptors indicates that these molecules may play non-redundant functions in the regulation of both innate and adaptive immune responses.

  15. High resolution study of U235(nsub(th),f) and Th229(nsub(th), f) with Cosi Fan Tutte mass spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Sicre, A.; Barreau, G.; Boukellal, A.

    1986-01-01

    The new built Cosi Fan Tutte facility installed at the High Flux Reactor of the ILL in Grenoble was used to obtain correlated mass, kinetic energy and nuclear charge of the fission fragments from U235(nsub(th),f) and Th229(nsub(th),f).

  16. Draft Genome Sequence of Acinetobacter bereziniae HPC229, a Carbapenem-Resistant Clinical Strain from Argentina Harboring blaNDM-1

    Science.gov (United States)

    Brovedan, Marco; Marchiaro, Patricia M.; Morán-Barrio, Jorgelina; Revale, Santiago; Cameranesi, Marcela; Brambilla, Luciano; Viale, Alejandro M.

    2016-01-01

    We report here the draft genome sequence of an NDM-1-producing Acinetobacter bereziniae clinical strain, HPC229. This strain harbors both plasmid and chromosomal resistance determinants toward different β-lactams and aminoglycosides as well as several types of multidrug efflux pumps, most likely representing an adaptation strategy for survival under different environments. PMID:26966220

  17. Contralateral hip fractures and other osteoporosis-related fractures in hip fracture patients: Incidence and risk factors. An observational cohort study of 1,229 patients

    NARCIS (Netherlands)

    A.J.H. Vochteloo (Anne); B.L. Borger van der Burg (Boudewijn); M.L. Röling (Maarten); D.H.-J. van Leeuwen (Diederik); P. van den Berg (Peter); A.H.P. Niggebrugge (Arthur); M.R. de Vries (Mark); W.E. Tuinebreijer (Wim); R.M. Bloem (Rolf); R.G.H.H. Nelissen (Rob); P. Pilot (Peter)

    2012-01-01

    textabstractPurpose: To report risk factors, 1-year and overall risk for a contralateral hip and other osteoporosis-related fractures in a hip fracture population. Methods: An observational study on 1,229 consecutive patients of 50 years and older, who sustained a hip fracture between January 2005

  18. Magnetic hyperfine structure of the ground-state doublet in highly charged ions 89+,87+229Th and the Bohr-Weisskopf effect

    Science.gov (United States)

    Tkalya, E. V.; Nikolaev, A. V.

    2016-07-01

    Background: The search for new opportunities to investigate the low-energy level in the 229Th nucleus, which is nowadays intensively studied experimentally, has motivated us to theoretical studies of the magnetic hyperfine (MHF) structure of the 5 /2+ (0.0 eV) ground state and the low-lying 3 /2+ (7.8 eV) isomeric state in highly charged 89+229Th and 87+229Th ions. Purpose: The aim is to calculate, with the maximal precision presently achievable, the energy of levels of the hyperfine structure of the 229Th ground-state doublet in highly charged ions and the probability of radiative transitions between these levels. Methods: The distribution of the nuclear magnetization (the Bohr-Weisskopf effect) is accounted for in the framework of the collective nuclear model with Nilsson model wave functions for the unpaired neutron. Numerical calculations using precise atomic density functional theory methods, with full account of the electron self-consistent field, have been performed for the electron structure inside and outside the nuclear region. Results: The deviations of the MHF structure for the ground and isomeric states from their values in a model of a pointlike nuclear magnetic dipole are calculated. The influence of the mixing of the states with the same quantum number F on the energy of sublevels is studied. Taking into account the mixing of states, the probabilities of the transitions between the components of the MHF structure are calculated. Conclusions: Our findings are relevant for experiments with highly ionized 229Th ions in a storage ring at an accelerator facility.

  19. 北京某医学院229名医学生膳食营养状况分析%Dietary survey among 229 medical college students in Beijing

    Institute of Scientific and Technical Information of China (English)

    苑林宏; 肖忠新; 孟丽苹; 李昇; 王柳凝; 李楠; 纪健; 肖荣

    2011-01-01

    Objective To study the nutritional status among medicos aged 18-23 years in Beijing and to provide evidence-based for making dietary intervention strategy. Methods A 24h dietary recall was carried out for 3 days to investigate the food intake of 229 medical college students and analyze the nutritional status. Results The food intake of medical college students were plentiful, and grains, potato and vegetables intake were in great amount and made the base of the diet. However, the intake of milk and milk products, marine products were lower than the DRls. Rational intake of energy-yielding nutrients was found in this study. The protein intake was enough, but good quality protein accounted for less than 50% of total protein intake. Calcium, zinc, vitamin B1 and vitamin B2 intake were inadequate. Conclusion The distribution of three macro-nutrients is reasonable. However, there is deficiency in the dietary pattern of medical college students and dietary nutrition education is necessary in the college.%目的 了解北京市医学生膳食营养状况,为全面提高大学生身体素质、制定切实可行的膳食干预策略提供理论依据.方法 采用连续3d的24h回顾法,对北京市某医学院校229名学生进行连续3d膳食调查,并进行膳食营养状况分析.结果 医学生摄入的食物较丰富,以谷薯类、蔬菜类食物为主,乳类及水产品的摄入量尚未达到膳食参考摄入量.三大产能营养素供能比较合理,蛋白质的摄入量充足,但优质蛋白质的摄入量较低.钙、锌和维生素B1、B2的摄人量与推荐量的差距较大.结论 医学生的能量来源分布基本合理,但膳食结构不合理.需要进一步加强营养教育与干预,以保证均衡饮食和合理营养.

  20. Analysis of curative effect of gamma knife radiosurgery on 229 cases of acoustic neuromas%伽玛刀治疗听神经瘤229例疗效分析

    Institute of Scientific and Technical Information of China (English)

    粱恩顺; 佘永传

    2012-01-01

    Objective To evaluate the effect of the gamma Knife radiosurgery on acoustic neuromas. Methods 229 patients with acoustic neuromas were treated with OUR Rotating Gamma System, and the postoperative condition was observed. Result Follow-up ranged from 6 to 60 months in the group,tumor size reduced in 98 patients,remained unchanged in 115 and increased in 16. Functional hearing was reduced in 38 patients and preserved in 130 who had useful hearing prior to gamma knife treatment. 54 patients developed new facial paralysis and 11 developed trigeminal injury. Conclusion Gamma -knife radiosurgery achieves high tumor control rate for acoustic ncuromas with preservation of functional hearing, minimal facial and trigeminal injury. It provides an optional treatment for patients with small to medium size acoustic neuromas, and an important adjuvant therapy for treating residual and recurrent tumors.%[目的]评价伽玛刀治疗听神经瘤的疗效.[方法]采用OUR旋转式伽玛刀治疗229例听神经瘤患者,观察术后病情变化.[结果]本组伽玛刀治疗病例随访6~60个月,其中肿瘤缩小98例,肿瘤体积不变115例,肿瘤增大16例,治疗前存在有用听力病例中38例听力下降;130例患者有用听力得到保留;54例出现患侧面瘫;11例出现三叉神经功能部分受损.[结论]伽玛刀对听神经瘤有较高的肿瘤控制率,并能保留有用听力,对面神经、三又神经损伤小,是小至中等大小听神经瘤可供选择的治疗[方法],及术后残余和复发肿瘤的重要辅助治疗手段.

  1. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Science.gov (United States)

    2010-01-01

    ... Category 1(TBq) Category 1(Ci) Category 2(TBq) Category 2(Ci) Actinium-227 20 540 0.2 5.4 Americium-241 60... 2 54 Strontium-90 1,000 27,000 10 270 Thorium-228 20 540 0.2 5.4 Thorium-229 20 540 0.2 5.4...

  2. Identification of SLAMF3 (CD229) as an Inhibitor of Hepatocellular Carcinoma Cell Proliferation and Tumour Progression

    Science.gov (United States)

    Cartier, Flora; Amrathlal, Rabbind Singh; Ossart, Christèle; Ouled-Haddou, Hakim; Ghamlouch, Hussein; Galmiche, Antoine; Chatelain, Denis; Lamotte, Luciane; Debuysscher, Véronique; Fuentes, Vincent; Nguyen-Khac, Eric; Regimbeau, Jean-Marc; Marolleau, Jean-Pierre; Latour, Sylvain; Bouhlal, Hicham

    2013-01-01

    Although hepatocellular carcinoma (HCC) is one of the most common malignancies and constitutes the third leading cause of cancer-related deaths, the underlying molecular mechanisms are not fully understood. In the present study, we demonstrate for the first time that hepatocytes express signalling lymphocytic activation molecule family member 3 (SLAMF3/CD229) but not other SLAMF members. We provide evidence to show that SLAMF3 is involved in the control of hepatocyte proliferation and in hepatocellular carcinogenesis. SLAMF3 expression is significantly lower in primary human HCC samples and HCC cell lines than in human healthy primary hepatocytes. In HCC cell lines, the restoration of high levels of SLAMF3 expression inhibited cell proliferation and migration and enhanced apoptosis. Furthermore, SLAMF3 expression was associated with inhibition of HCC xenograft progression in the nude mouse model. The restoration of SLAMF3 expression levels also decreased the phosphorylation of MAPK ERK1/2, JNK and mTOR. In samples from resected HCC patients, SLAMF3 expression levels were significantly lower in tumorous tissues than in peritumoral tissues. Our results identify SLAMF3 as a specific marker of normal hepatocytes and provide evidence for its potential role in the control of proliferation of HCC cells. PMID:24376606

  3. Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression.

    Science.gov (United States)

    Marcq, Ingrid; Nyga, Rémy; Cartier, Flora; Amrathlal, Rabbind Singh; Ossart, Christèle; Ouled-Haddou, Hakim; Ghamlouch, Hussein; Galmiche, Antoine; Chatelain, Denis; Lamotte, Luciane; Debuysscher, Véronique; Fuentes, Vincent; Nguyen-Khac, Eric; Regimbeau, Jean-Marc; Marolleau, Jean-Pierre; Latour, Sylvain; Bouhlal, Hicham

    2013-01-01

    Although hepatocellular carcinoma (HCC) is one of the most common malignancies and constitutes the third leading cause of cancer-related deaths, the underlying molecular mechanisms are not fully understood. In the present study, we demonstrate for the first time that hepatocytes express signalling lymphocytic activation molecule family member 3 (SLAMF3/CD229) but not other SLAMF members. We provide evidence to show that SLAMF3 is involved in the control of hepatocyte proliferation and in hepatocellular carcinogenesis. SLAMF3 expression is significantly lower in primary human HCC samples and HCC cell lines than in human healthy primary hepatocytes. In HCC cell lines, the restoration of high levels of SLAMF3 expression inhibited cell proliferation and migration and enhanced apoptosis. Furthermore, SLAMF3 expression was associated with inhibition of HCC xenograft progression in the nude mouse model. The restoration of SLAMF3 expression levels also decreased the phosphorylation of MAPK ERK1/2, JNK and mTOR. In samples from resected HCC patients, SLAMF3 expression levels were significantly lower in tumorous tissues than in peritumoral tissues. Our results identify SLAMF3 as a specific marker of normal hepatocytes and provide evidence for its potential role in the control of proliferation of HCC cells.

  4. Identification of SLAMF3 (CD229 as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression.

    Directory of Open Access Journals (Sweden)

    Ingrid Marcq

    Full Text Available Although hepatocellular carcinoma (HCC is one of the most common malignancies and constitutes the third leading cause of cancer-related deaths, the underlying molecular mechanisms are not fully understood. In the present study, we demonstrate for the first time that hepatocytes express signalling lymphocytic activation molecule family member 3 (SLAMF3/CD229 but not other SLAMF members. We provide evidence to show that SLAMF3 is involved in the control of hepatocyte proliferation and in hepatocellular carcinogenesis. SLAMF3 expression is significantly lower in primary human HCC samples and HCC cell lines than in human healthy primary hepatocytes. In HCC cell lines, the restoration of high levels of SLAMF3 expression inhibited cell proliferation and migration and enhanced apoptosis. Furthermore, SLAMF3 expression was associated with inhibition of HCC xenograft progression in the nude mouse model. The restoration of SLAMF3 expression levels also decreased the phosphorylation of MAPK ERK1/2, JNK and mTOR. In samples from resected HCC patients, SLAMF3 expression levels were significantly lower in tumorous tissues than in peritumoral tissues. Our results identify SLAMF3 as a specific marker of normal hepatocytes and provide evidence for its potential role in the control of proliferation of HCC cells.

  5. The fracture network model of Shen 229 block buried hill:A case study from Liaohe Basin, China

    Institute of Scientific and Technical Information of China (English)

    XING Yu-zhong; FAN Tai-liang; ZHENG Li-hui

    2006-01-01

    High oil production from the Proterozoic formation of Shen 229 block in Damingtun Depression, Liaohe Basin, China,indicates the presence of natural fractured reservoir whose production potential is dominated by the structural fracture. A consistent structural model and good knowledge of the fracture systems are therefore of key importance in reducing risk in the development strategies. So data from cores and image logs have been collected to account for the basic characteristics of fracture, and then the analyzed results were integrated with the structural model in order to restrict the fracture network development during the structural evolvement. The structural evolution of the Proterozoic reservoir with time forms the basis for understanding the development of the 3D fracture system. Seismic interpretation and formation correlation were used to build a 3D geological model.The fault blocks that compose the Proterozoic formation reservoir were subsequently restored to their pre-deformation. From here,the structures were kinematically modeled to simulate the structural evolution of the reservoirs. At each time step, the dilatational and cumulative strain was calculated throughout the modelling history. The total strain which records the total spatial variation in the reservoir due to its structural history, together with core data, well data and the lithology distribution, was used to simulate geologically realistic discrete fracture networks. The benefit of this technique over traditional curvature analysis is that the structural evolution is taken into account, a factor that mostly dominates fracture formation.

  6. K2-29 b/WASP-152 b: An Aligned and Inflated Hot Jupiter in a Young Visual Binary

    Science.gov (United States)

    Santerne, A.; Hébrard, G.; Lillo-Box, J.; Armstrong, D. J.; Barros, S. C. C.; Demangeon, O.; Barrado, D.; Debackere, A.; Deleuil, M.; Delgado Mena, E.; Montalto, M.; Pollacco, D.; Osborn, H. P.; Sousa, S. G.; Abe, L.; Adibekyan, V.; Almenara, J.-M.; André, P.; Arlic, G.; Barthe, G.; Bendjoya, P.; Behrend, R.; Boisse, I.; Bouchy, F.; Boussier, H.; Bretton, M.; Brown, D. J. A.; Carry, B.; Cailleau, A.; Conseil, E.; Coulon, G.; Courcol, B.; Dauchet, B.; Dalouzy, J.-C.; Deldem, M.; Desormières, O.; Dubreuil, P.; Fehrenbach, J.-M.; Ferratfiat, S.; Girelli, R.; Gregorio, J.; Jaecques, S.; Kugel, F.; Kirk, J.; Labrevoir, O.; Lachurié, J.-C.; Lam, K. W. F.; Le Guen, P.; Martinez, P.; Maurin, L. P. A.; McCormac, J.; Pioppa, J.-B.; Quadri, U.; Rajpurohit, A.; Rey, J.; Rivet, J.-P.; Roy, R.; Santos, N. C.; Signoret, F.; Strabla, L.; Suarez, O.; Toublanc, D.; Tsantaki, M.; Vienney, J.-M.; Wilson, P. A.; Bachschmidt, M.; Colas, F.; Gerteis, O.; Louis, P.; Mario, J.-C.; Marlot, C.; Montier, J.; Perroud, V.; Pic, V.; Romeuf, D.; Ubaud, S.; Verilhac, D.

    2016-06-01

    In the present paper we report the discovery of a new hot Jupiter, K2-29 b, first detected by the Super-WASP observatory and then by the K2 space mission during its campaign 4. The planet has a period of 3.25 days, a mass of 0.73 ± 0.04 M ♃, and a radius of 1.19 ± 0.02 R ♃. The host star is a relatively bright (V = 12.5) G7 dwarf with a nearby K5V companion. Based on stellar rotation and the abundance of lithium, we find that the system might be as young as ~450 Myr. The observation of the Rossiter-McLaughlin effect shows that the planet is aligned with respect to the stellar spin. Given the deep transit (20 mmag), the magnitude of the star and the presence of a nearby stellar companion, the planet is a good target for both space- and ground-based transmission spectroscopy, in particular in the near-infrared where both stars are relatively bright.

  7. A possible association of a human tektin-t gene mutation (A229V) with isolated non-syndromic asthenozoospermia: case report.

    Science.gov (United States)

    Zuccarello, Daniela; Ferlin, Alberto; Garolla, Andrea; Pati, Mauro A; Moretti, Afra; Cazzadore, Carla; Francavilla, Sandro; Foresta, Carlo

    2008-04-01

    Asthenozoospermia (AZS), characterized by grade A + B sperm motility (as in World Health Organization Guidelines) or =80% of examined spermatozoa involving axoneme microtubules and mitochondria. Moreover, the viability and mitochondrial function of sperm were altered in the patient with the A229V mutation. This is the first description of human pathology linked to a tektin-family gene, since only murine models are available for these genes.

  8. Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses.

    Science.gov (United States)

    Cuenca, Marta; Romero, Xavier; Sintes, Jordi; Terhorst, Cox; Engel, Pablo

    2016-01-15

    Marginal zone (MZ) and B1 B cells have the capacity to respond to foreign Ags more rapidly than conventional B cells, providing early immune responses to blood-borne pathogens. Ly9 (CD229, SLAMF3), a member of the signaling lymphocytic activation molecule family receptors, has been implicated in the development and function of innate T lymphocytes. In this article, we provide evidence that in Ly9-deficient mice splenic transitional 1, MZ, and B1a B cells are markedly expanded, whereas development of B lymphocytes in bone marrow is unaltered. Consistent with an increased number of these B cell subsets, we detected elevated levels of IgG3 natural Abs and a striking increase of T-independent type II Abs after immunization with 2,4,6-trinitrophenyl-Ficoll in the serum of Ly9-deficient mice. The notion that Ly9 could be a negative regulator of innate-like B cell responses was supported by the observation that administering an mAb directed against Ly9 to wild-type mice selectively eliminated splenic MZ B cells and significantly reduced the numbers of B1 and transitional 1 B cells. In addition, Ly9 mAb dramatically diminished in vivo humoral responses and caused a selective downregulation of the CD19/CD21/CD81 complex on B cells and concomitantly an impaired B cell survival and activation in an Fc-independent manner. We conclude that altered signaling caused by the absence of Ly9 or induced by anti-Ly9 may negatively regulate development and function of innate-like B cells by modulating B cell activation thresholds. The results suggest that Ly9 could serve as a novel target for the treatment of B cell-related diseases.

  9. Targeting of Ly9 (CD229) disrupts marginal zone and B1 B cell homeostasis and antibody responses1

    Science.gov (United States)

    Cuenca, Marta; Romero, Xavier; Sintes, Jordi; Terhorst, Cox; Engel, Pablo

    2015-01-01

    Marginal zone and B1 B-cells have the capacity to respond to foreign antigens more rapidly than conventional B-cells, providing early immune responses to blood-borne pathogens. Ly9 (CD229, SLAMF3), a member of the SLAM family receptors, has been implicated in the development and function of innate T lymphocytes. Here, we provide evidence that in Ly9-deficient mice splenic transitional T1, marginal zone and B1a B cells are markedly expanded, whilst development of B lymphocytes in bone marrow is unaltered. Consistent with an increased number of these B cell subsets, we detect elevated levels of IgG3 natural antibodies, and a striking increase of T-independent type II antibodies following immunization with TNP-Ficoll in the serum of Ly9-deficient mice. The notion that Ly9 could be a negative regulator of innate-like B cell responses was supported by the observation that administering a mAb directed against Ly9 to WT mice selectively eliminated splenic marginal zone B cells and significantly reduced the numbers of B1 and transitional T1 B cells. Additionally, Ly9 mAb dramatically diminished in vivo humoral responses and caused a selective down-regulation of the CD19/CD21/CD81 complex on B cells and concomitantly an impaired B cell survival and activation in a Fc-independent manner. We conclude that altered signaling due to the absence of Ly9 or induced by anti-Ly9 may negatively regulate development and function of innate-like B cells by modulating B cell activation thresholds. The results suggest that Ly9 could serve as a novel target for the treatment of B cell related diseases. PMID:26667173

  10. No-mesh inguinal hernia repair with continuous absorbable sutures: A dream or reality? (a study of 229 patients

    Directory of Open Access Journals (Sweden)

    Desarda Mohan

    2008-01-01

    Full Text Available Background/Aim: The author has published results from two series based on his new technique of inguinal hernia repair. Interrupted sutures with a nonabsorbable material were used for repairs in both theses series. The author now describes the results of repairs done with continuous absorbable sutures. Materials and Methods: This is a prospective study of 229 patients having 256 hernias operated from December 2003 to December 2006. An undetached strip of the external oblique aponeurosis was sutured between the inguinal ligament and the muscle arch to form the new posterior wall. Continuous sutures were taken with absorbable suture material (Monofilament Polydioxanone Violet. Data of hospital stay, complications, ambulation, recurrences, and pain were recorded. Follow-up was done until June 2007. Results: A total of 224 (97.8% patients were ambulatory within 6-8 h (mean: 6.42 h and they attained free ambulation within 18-24 h (mean: 19.26 h. A total of 222 (96.4% patients returned to work within 6-14 days (mean: 8.62 days and 209 (91.26% patients had one-night stays in the hospital. A total of 216 (94.3% patients had mild pain for 2 days. There were four minor complications, but no recurrence or incidence of chronic groin pain. Patients were followed up for a mean period of 24.28 months (range: 6-42 months. Conclusions: The results of this study correlate well with the author′s previous publications. Continuous suturing saves operative time and one packet of suture material. The dream of every surgeon to give recurrence-free inguinal hernia repair without leaving any foreign body inside the patient may well become a reality in future.

  11. Isolation of Actinium from Neutron-irradiated Thorium-I

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Isolation of Actinium from Neutron-irradiated Thorium-I¥YangWeifan;YuanShuanggui;MuWantong;ZhangXueqian;LiZhongweiandZhaoLili...

  12. 229 ORIGINAL ARTICLE

    African Journals Online (AJOL)

    boaz

    and sub-cultures; with 24 (20%) of the pure isolates testing positive as being pathogenic after ... identification and detection of virulent strains of Salmonella species are of utmost importance. .... market, Bukuru market, Building Materials market ...

  13. Analysis of medication administering errors caused by nurses based on 229 cases and preventive strategies%229起护士给药错误分析及对策

    Institute of Scientific and Technical Information of China (English)

    蒋银芬; 杨如美; 佟伟军; 谭丽萍; 丁力

    2011-01-01

    目的 分析护士给药错误发生的原固和特点,探讨如何避免发生给药错误.方法 在建立半结构性非惩罚护理意外事件上报系统的基础上,回顾分析某三级综合性医院2008~2010年系统上报的229起给药错误事件,对护士发生给药缺陷的类型、特点、原因进行分析.结果 ①遗漏和"5R"类错误是护士给药错误的主要类别.给药错误的前三位原因为不遵守操作流程(低年资护士)、沟通不良和干扰(高年资护士).②护士年资是影响给药错误的重要因素,工作年限低于3年的护士给药错误发生率最高,3年以上者发生率明显降低.③护士给药错误容易发生在白天交接班时,尤其是在12:00左右.④与其他科室相比,外科护士给药错误的发生率更高.⑤给药错误各影响因素中,与结局相关者为沟通(P=0.044)、遗漏(P=0.019)、给药速度(P=0.008)、监测(P=0.000)和药品(P=0.009),Ⅱ级以上结局主要与高危药物有关.结论 护理管理人员应根据护士发生给药错误的特点制订针对性的预防措施.护士排班时应增加中午值班人员数量.对重点科室和高危药物应重点监测并提出降低给药错误的风险预案.%Objective To analyze the causes and characteristics of medication administering errors caused by nurses,and to explore preventive strategies. Methods The type,characteristics and causes of 229 cases of medication administering errors were retrospectively analyzed based on the records of the non-punitive adverse events reporting system in a first class hospital from 2008 to 2010. Results Omission and "five Rights" mistakes were the main types of medication administering errors.The first three causes were violation of checking procedures ,poor communication and distractions. Years of working experiencewas an important factor influencing medication administering errors. The incidence of medication administering errors in nurses working fewer than 3 years

  14. Utility of CD54, CD229, and CD319 for the identification of plasma cells in patients with clonal plasma cell diseases.

    Science.gov (United States)

    Pojero, Fanny; Flores-Montero, Juan; Sanoja, Luzalba; Pérez, José Juan; Puig, Noemí; Paiva, Bruno; Bottcher, Sebastian; van Dongen, Jacques J M; Orfao, Alberto

    2016-01-01

    Multiparameter flow cytometry (MFC) identification and characterization of plasma cells (PCs) is a useful tool to support diagnosis, prognostication, and monitoring of PC diseases (PCD). Currently, the number of MFC markers suited for the identification of PC remains limited. Moreover, antibody therapies against PC-associated markers further compromise the utility of the most widely used reagents (e.g., CD38). Despite markers other than CD38 and CD138 are recognized as potentially useful PC-identification markers, no study has comparatively evaluated their performance in combination with CD38 and CD138. Here we compared the utility of CD229, CD54, and CD319 for the identification of normal and aberrant PCs. Bone marrow (BM) samples from 5 healthy controls, two noninfiltrated nonHodgkin lymphoma cases and 46 PCD patients plus 3 extraosseous plasmocytomas, and normal peripheral blood (PB) specimens, were studied. Our results showed adequate performance of all three markers once combined with CD38. In contrast, when combined with CD138 for the identification of PC, only CD229 provided a good discrimination between PCs and all other cells for all BM and PB samples analyzed; in contrast, CD54 and CD319 showed limited utility for the identification of PCs, mainly because of significant overlap of the staining for these two markers on PCs and other myeloid cells in the sample. From the three markers evaluated, CD229 may be considered as the most reliable marker to replace CD38 or CD138 for the identification of PCs in patients undergoing anti-CD38 or anti-CD138 therapy, until a better alternative is available. © 2015 International Clinical Cytometry Society.

  15. La educación del fiel laico y los derechos humanos a la luz de los cánones 229 y 768

    OpenAIRE

    Laredo Romero, Andrea

    2015-01-01

    Este trabajo es la síntesis sobre la educación de los fieles laicos en el derecho canónico y el Magisterio de la Iglesia. La educación que pide la Iglesia para sus fieles es la centrada en la dignidad y libertad de la persona humana, en la unidad, estabilidad y deberes de la familia, en las obligaciones que corresponden a los hombres unidos en sociedad y en el modo de disponer los asuntos temporales según el orden establecido por Dios (c. 768,2). El c. 229 resalta el conocimiento de la doctri...

  16. A proposed experimental method to determine $\\alpha$-sensitivity of splitting between ground and 7.6 eV isomeric states in Th-229

    OpenAIRE

    Berengut, J. C.; Dzuba, V. A.; Flambaum, V. V.; Porsev, S. G.

    2009-01-01

    The 7.6 eV electromagnetic transition between the nearly degenerate ground state and first excited state in the Th-229 nucleus may be very sensitive to potential changes in the fine-structure constant, $\\alpha = e^2/\\hbar c$. However, the sensitivity is not known, and nuclear calculations are currently unable to determine it. We propose measurements of the differences of atomic transition frequencies between thorium atoms (or ions) with the nucleus in the ground state and in the first excited...

  17. Correction to the paper “a simple model to determine the interrelation between the integral characteristics of hall thrusters” [Plasma Physics Reports 40, 229 (2014)

    Energy Technology Data Exchange (ETDEWEB)

    Shumilin, V. P. [All-Russian Electrotechnical Institute (Russian Federation); Shumilin, A. V.; Shumilin, N. V., E-mail: vladimirshumilin@yahoo.com [Moscow Institute of Electronics and Mathematics (Russian Federation)

    2015-11-15

    The paper is devoted to comparison of experimental data with theoretical predictions concerning the dependence of the current of accelerated ions on the operating voltage of a Hall thruster with an anode layer. The error made in the paper published by the authors in Plasma Phys. Rep. 40, 229 (2014) occurred because of a misprint in the Encyclopedia of Low-Temperature Plasma. In the present paper, this error is corrected. It is shown that the simple model proposed in the above-mentioned paper is in qualitative and quantitative agreement with experimental results.

  18. Progress towards fabrication of Th:229-doped high energy band-gap crystals for use as a solid-state optical frequency reference

    CERN Document Server

    Rellergert, Wade G; DeMille, D; Greco, R R; Hehlen, M P; Jackson, R A; Torgerson, J R; Hudson, Eric R

    2010-01-01

    We have recently described a novel method for the construction of a solid-state optical frequency reference based on doping $^{229}$Th into high energy band-gap crystals. Since nuclear transitions are far less sensitive to environmental conditions than atomic transitions, we have argued that the $^{229}$Th optical nuclear transition may be driven inside a host crystal resulting in an optical frequency reference with a short-term stability of $3\\times10^{-17}<\\Delta f/f <1\\times10^{-15}$ at 1 s and a systematic-limited repeatability of $\\Delta f/f \\sim 2 \\times 10^{-16}$. Improvement by $10^2-10^3$ of the constraints on the variability of several important fundamental constants also appears possible. Here we present the results of the first phase of these experiments. Specifically, we have evaluated several high energy band-gap crystals (Th:NaYF, Th:YLF, Th:LiCAF, Na$_2$ThF$_6$, LiSAF) for their suitability as a crystal host by a combination of electron beam microprobe measurements, Rutherford Backscatte...

  19. Assessment of surface reactivity of thorium oxide in conditions close to chemical equilibrium by isotope exchange {sup 229}Th/{sup 232}Th method

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki-Muresan, Tomo; Perrigaud, Katy; Vandenborre, Johan; Ribet, Solange; Grambow, Bernd [Nantes Univ., CNRS/IN2P3 (France). SUBATECH Unite Mixte de Recherche 6457; Takamasa, Inai [TOKAI Univ., Kanagawa (Japan)

    2017-08-01

    This work aims to assess the solubility and the surface reactivity of crystallized thorium at pH 3.0 in presence of three types of solids: synthesized powder at 1300 C, crushed kernel, and intact kernel. In this study, the kernel is composed by the core solid from high temperature reactors (HTR) sphere particles. The originality of this work consisted in following in a sequential order the kinetic of dissolution, the surface reactivity in presence of isotope tracer {sup 229}Th, and its desorption process. Long time experiments (634 days) allowed to get deeper understanding on the behavior of the surface reactivity in contact with the solution. Solubility values are ranging from 0.3 x 10{sup -7} mol.L{sup -1} to 3 x 10{sup -7} mol.L{sup -1} with a dissolution rate of 10{sup -6}-10{sup -4} g.m{sup -2} day{sup -1}. PHREEQC modeling showed that crystallized ThO{sub 2}(cr, 20 nm) phase controls the equilibrium in solution. Isotope exchange between {sup 229}Th and {sup 232}Th indicated that well-crystallized phase exist as an inert surface regarding to the absence of exchange between surface solid and solution.

  20. Peptides derived from HIV-1, HIV-2, Ebola virus, SARS coronavirus and coronavirus 229E exhibit high affinity binding to the formyl peptide receptor

    Science.gov (United States)

    Mills, John S.

    2007-01-01

    Peptides derived from the membrane proximal region of fusion proteins of human immunodeficiency viruses 1 and 2, Coronavirus 229 E, severe acute respiratory syndrome coronavirus and Ebola virus were all potent antagonists of the formyl peptide receptor expressed in Chinese hamster ovary cells. Binding of viral peptides was affected by the naturally occurring polymorphisms at residues 190 and 192, which are located at second extracellular loop-transmembrane helix 5 interface. Substitution of R190 with W190 enhanced the affinity for a severe acute respiratory syndrome coronavirus peptide 6 fold but reduced the affinity for N-formyl-Nle–Leu-Phe by 2.5 fold. A 12 mer peptide derived from coronavirus 229E (ETYIKPWWVWL) was the most potent antagonist of the formyl peptide receptor W190 with a Ki of 230 nM. Fluorescently labeled ETYIKPWWVWL was effectively internalized by all three variants with EC50 of ~25 nM. An HKU-1 coronavirus peptide, MYVKWPWYVWL, was a potent antagonist but N-formyl-MYVKWPWYVWL was a potent agonist. ETYIKPWWVWL did not stimulate GTPγS binding but inhibited the stimulation by formyl-NleLeuPhe. It also blocked β arrestin translocation and receptor downregulation induced by formyl-Nle–Leu–Phe. This indicates that formyl peptide receptor may be important in viral infections and that variations in its sequence among individuals may affect their likelihood of viral and bacterial infections. PMID:16842982

  1. Di-Ethylhexylphthalate (DEHP Modulates Cell Invasion, Migration and Anchorage Independent Growth through Targeting S100P in LN-229 Glioblastoma Cells

    Directory of Open Access Journals (Sweden)

    Jennifer Nicole Sims

    2014-05-01

    Full Text Available Glioblastoma multiforme (GBM is the most aggressive brain cancer with a median survival of 1–2 years. The treatment of GBM includes surgical resection, radiation and chemotherapy, which minimally extends survival. This poor prognosis necessitates the identification of novel molecular targets associated with glioblastoma. S100P is associated with drug resistance, metastasis, and poor clinical outcomes in many malignancies. The functional role of S100P in glioblastoma has not been fully investigated. In this study, we examined the role of S100P mediating the effects of the environmental contaminant, DEHP, in glioblastoma cells (LN-229 by assessing cell proliferation, apoptosis, anchorage independent growth, cell migration and invasion following DEHP exposure. Silencing S100P and DEHP treatment inhibited LN-229 glioblastoma cell proliferation and induced apoptosis. Anchorage independent growth study revealed significantly decreased colony formation in shS100P cells. We also observed reduced cell migration in cells treated with DEHP following S100P knockdown. Similar results were observed in spheroid formation and expansion. This study is the first to demonstrate the effects of DEHP on glioblastoma cells, and implicates S100P as a potential therapeutic target that may be useful as a drug response biomarker.

  2. Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells.

    Science.gov (United States)

    Hagberg, Niklas; Theorell, Jakob; Schlums, Heinrich; Eloranta, Maija-Leena; Bryceson, Yenan T; Rönnblom, Lars

    2013-09-15

    Patients with systemic lupus erythematosus (SLE) display an activated type I IFN system due to unceasing IFN-α release from plasmacytoid dendritic cells (pDCs) stimulated by nucleic acid-containing immune complexes (ICs). NK cells strongly promote the IFN-α production by pDCs; therefore, we investigated surface molecules that could be involved in the pDC-NK cell cross-talk. In human PBMCs stimulated with RNA-containing ICs (RNA-ICs), the expression of the signaling lymphocyte activation molecule (SLAM) family receptors CD319 and CD229 on pDCs and CD319 on CD56(dim) NK cells was selectively increased. Upregulation of CD319 and CD229 on RNA-IC-stimulated pDCs was induced by NK cells or cytokines (e.g., GM-CSF, IL-3). IFN-α-producing pDCs displayed a higher expression of SLAM molecules compared with IFN-α⁻ pDCs. With regard to signaling downstream of SLAM receptors, pDCs expressed SHIP-1, SHP-1, SHP-2, and CSK but lacked SLAM-associated protein (SAP) and Ewing's sarcoma-activated transcript 2 (EAT2), indicating that these receptors may act as inhibitory receptors on pDCs. Furthermore, pDCs from patients with SLE had decreased expression of CD319 on pDCs and CD229 on CD56(dim) NK cells, but RNA-IC stimulation increased CD319 and CD229 expression. In conclusion, this study reveals that the expression of the SLAM receptors CD319 and CD229 is regulated on pDCs and NK cells by lupus ICs and that the expression of these receptors is specifically altered in SLE. These results, together with the observed genetic association between the SLAM locus and SLE, suggest a role for CD319 and CD229 in the SLE disease process.

  3. Magnetic hyperfine structure of the ground-state doublet in highly charged ions $^{229}$Th$^{89+,87+}$ and the Bohr-Weisskopf effect

    CERN Document Server

    Tkalya, E V

    2016-01-01

    The magnetic hyperfine (MHF) structure of the $5/2^+$(0.0 eV) ground state and the low-lying $3/2^+$(7.8 eV) isomeric state of the $^{229}$Th nucleus in highly charged ions Th$^{89+}$ and Th$^{87+}$ is calculated. The distribution of the nuclear magnetization (the Bohr-Weisskopf effect) is accounted for in the framework of the collective nuclear model with the wave functions of the Nilsson model for the unpaired neutron. The deviations of the MHF structure for the ground and isomeric states from their values in the model of point-like nuclear magnetic dipole are calculated. The influence of the mixing of the states with the same quantum number $F$ on the energy of sublevels is studied. Taking into account the mixing of states, the probabilities of the transitions between the components of MHF structure are found.

  4. Discovery of Eclipsing Binary Central Stars in the Planetary Nebulae M 3-16, H 2-29 and M 2-19

    CERN Document Server

    Miszalski, B; Moffat, A F J; Parker, Q A; Udalski, A

    2008-01-01

    Progress in understanding the formation and evolution of planetary nebulae (PN) has been restricted by a paucity of well-determined central star masses. To address this deficiency we aim to (i) significantly increase the number of known eclipsing binary central stars of PN (CSPN), and subsequently (ii) directly obtain their masses and absolute dimensions by combining their light-curve parameters with planned radial velocity data. Using photometric data from the third phase of the Optical Gravitational Lensing Experiment (OGLE) we have searched for periodic variability in a large sample of PN towards the Galactic Bulge using Fourier and phase-dispersion minimisation techniques. Among some dozen periodically variable CSPN found, we report here on three new eclipsing binaries: M 3-16, H 2-29 and M 2-19. We present images, confirmatory spectroscopy and light-curves of the systems.

  5. Band structure and decay channels of thorium-229 low-lying isomeric state for ensemble of thorium atoms adsorbed on calcium fluoride

    Energy Technology Data Exchange (ETDEWEB)

    Borisyuk, Petr V.; Vasilyev, Oleg S.; Krasavin, Andrey V.; Troyan, Victor I. [National Research Nuclear University ' ' MEPhI' ' (Moscow Engineering Physics Institute), Kashirskoye shosse 31, 115409 Moscow (Russian Federation); Lebedinskii, Yury Yu. [National Research Nuclear University ' ' MEPhI' ' (Moscow Engineering Physics Institute), Kashirskoye shosse 31, 115409 Moscow (Russian Federation); Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, 141700 Dolgoprudny, Moscow region (Russian Federation); Tkalya, Eugene V. [Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie gory, 119991 Moscow (Russian Federation); Nuclear Safety Institute of Russian Academy of Science, Bol' shaya Tulskaya 52, 115191 Moscow (Russian Federation)

    2015-12-15

    The results are presented on the study of the electronic structure of thorium atoms adsorbed by the liquid atomic layer deposition from aqueous solution of thorium nitrate on the surface of CaF{sub 2}. The chemical state of the atoms and the change of the band structure in the surface layers of Th/CaF{sub 2} system on CaF{sub 2} substrate were investigated by XPS and REELS techniques. It was found that REELS spectra for Th/CaF{sub 2} system include peaks in the region of low energy losses (3-7 eV) which are missing in the similar spectra for pure CaF{sub 2}. It is concluded that the presence of the observed features in the REELS spectra is associated with the chemical state of thorium atoms and is caused by the presence of uncompensated chemical bonds at the Th/CaF{sub 2} interface, and, therefore, by the presence of unbound 6d- and 7s-electrons of thorium atoms. Assuming the equivalence of the electronic configuration of thorium-229 and thorium-232 atoms, an estimate was made on the time decay of the excited state of thorium-229 nuclei through the channel of the electron conversion. It was found that the relaxation time is about 40 μs for 6d-electrons, and about 1 μs for 7s-electrons. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  6. Optical/Near-IR Polarization Survey of Sh 2-29: Magnetic Fields, Dense Cloud Fragmentations and Anomalous Dust Grain Sizes

    CERN Document Server

    Santos, Fábio P; Roman-Lopes, Alexandre; Reis, Wilson; Román-Zúñiga, Carlos G

    2013-01-01

    Sh 2-29 is a conspicuous star-forming region marked by the presence of massive embedded stars as well as several notable interstellar structures. In this research, our goals were to determine the role of magnetic fields and to study the size distribution of interstellar dust particles within this turbulent environment. We have used a set of optical and near-infrared polarimetric data obtained at OPD/LNA (Brazil) and CTIO (Chile), correlated with extinction maps, 2MASS data and images from DSS and Spitzer. The region's most striking feature is a swept out interstellar cavity whose polarimetric maps indicate that magnetic field lines were dragged outwards, pilling up along its borders. This led to a higher magnetic strength value ($\\approx400\\,\\mu$G) and an abrupt increase in polarization degree, probably due to an enhancement in alignment efficiency. Furthermore, dense cloud fragmentations with peak $A_{V}$ between 20 and 37 mag were probably triggered by its expansion. The presence of $24\\,\\mu$m point-like so...

  7. Resonance ionization spectroscopy of thorium isotopes - towards a laser spectroscopic identification of the low-lying 7.6 eV isomer of $^{229}$Th

    CERN Document Server

    Raeder, S; Wendt, K; Sonnenschein, V; Trautmann, N; Rothe, S; Reponen, M; Gottwald, T; 10.1088/0953-4075/44/16/165005

    2011-01-01

    In-source resonance ionization spectroscopy was used to identify an efficient and selective three step excitation/ionization scheme of thorium, suitable for titanium:sapphire (Ti:sa) lasers. The measurements were carried out in preparation of laser spectroscopic investigations for an identification of the low-lying Th-229m isomer predicted at 7.6 +- 0.5 eV above the nuclear ground state. Using a sample of Th-232, a multitude of optical transitions leading to over 20 previously unknown intermediate states of even parity as well as numerous high-lying odd parity auto-ionizing states were identified. Level energies were determined with an accuracy of 0.06 cm-1 for intermediate and 0.15 cm-1 for auto-ionizing states. Using different excitation pathways an assignment of total angular momenta for several energy levels was possible. One particularly efficient ionization scheme of thorium, exhibiting saturation in all three optical transitions, was studied in detail. For all three levels in this scheme, the isotope s...

  8. Laser excitation of 8-eV electronic states in Th{sup +}. A first pillar of the electronic bridge toward excitation of the Th-229 nucleus

    Energy Technology Data Exchange (ETDEWEB)

    Herrera-Sancho, Oscar-Andrey

    2012-11-23

    The possibility to realize a nuclear clock based on the optical magnetic dipole transition from the ground state to the low-energy isomeric state in the {sup 229}Th nucleus has motivated experiments and proposals toward highly accurate clocks with trapped ions and highly stable optical frequency standards with Th-doped solids. These systems hold great promise to open a field of research in the borderland between atomic and nuclear physics, which will enable highly sensitive tests of postulates from fundamental physics and also will allow us to coherently excite and control nuclear states, opening a wonderful and intriguing new field in physics. A major experimental obstacle that has to be overcome before any precision spectroscopy can be performed with this system is however the insufficient knowledge on the exact transition energy. The best experimental result so far is an indirect determination from {gamma}-spectroscopy with a relative uncertainty of about 6%. To facilitate the search for the nuclear transition within a wide uncertainty range around 8 eV, we investigate two-photon excitation in the dense electronic level structure of Th{sup +}, which enables the nuclear excitation via a resonantly enhanced inverse electronic bridge process. Experiments on one- and two-photon laser excitation of buffer gas cooled {sup 232}Th{sup +} ions in a radio-frequency ion trap are reported in this thesis. The strongest resonance line at 402 nm from the (6d{sup 2}7s)J=3/2 ground state to the (6d7s7p)J=5/2 state is driven as the first excitation step. Using nanosecond laser pulses in the 250-nm wavelength range for the second step of a two-photon excitation, we have observed seven previously unknown levels in the unexplored region of the electronic level structure around 8 eV. This investigation shows that the Th{sup +} ion seems to be well suited for the search of the isomer transition because both, theory and experimental results, agree on the density of strong transitions

  9. Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice.

    Science.gov (United States)

    Graham, Daniel B; Bell, Michael P; McCausland, Megan M; Huntoon, Catherine J; van Deursen, Jan; Faubion, William A; Crotty, Shane; McKean, David J

    2006-01-01

    Signaling lymphocyte activation molecule (SLAM) family receptors are critically involved in modulating innate and adaptive immune responses. Several SLAM family receptors have been shown to interact with the adaptor molecule SAP; however, subsequent intracellular signaling is poorly defined. Notably, mutations in SLAM-associated protein (SAP) lead to X-linked lymphoproliferative disease, a rare but fatal immunodeficiency. Although the SLAM family member Ly9 (CD229) is known to interact with SAP, the functions of this receptor have remained elusive. Therefore, we have generated Ly9-/- mice and compared their phenotype with that of SLAM-/- and SAP-/- mice. We report that Ly9-/- T cells exhibit a mild Th2 defect associated with reduced IL-4 production after stimulation with anti-TCR and anti-CD28 in vitro. This defect is similar in magnitude to the previously reported Th2 defect in SLAM-/- mice but is more subtle than that observed in SAP-/- mice. In contrast to SLAM-/- and SAP-/- mice, T cells from Ly9-/- mice proliferate poorly and produce little IL-2 after suboptimal stimulation with anti-CD3 in vitro. We have also found that Ly9-/- macrophages exhibit no defects in cytokine production or bacterial killing as was observed in SLAM-/- macrophages. Additionally, Ly9-/- mice differ from SAP-/- mice in that they foster normal development of NKT cells and mount appropriate T and B cell responses to lymphocytic choriomeningitis virus. We have identified significant phenotypic differences between Ly-9-/- mice as compared with both SLAM-/- and SAP-/- mice. Although Ly9, SLAM, and SAP play a common role in promoting Th2 polarization, Ly-9 is uniquely involved in enhancing T cell activation.

  10. High resolution measurements of mass, energy and nuclear charge correlations for sup 229 Th(n sub th ,f) with the COSI FAN TUTTE spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Boucheneb, N. (Bordeaux-1 Univ., 33 - Gradignan (France). Centre d' Etudes Nucleaires; Universite des Sciences et de la Technologie Houari Boumedienne, Algiers (Algeria). Inst. de Physique); Geltenbort, P.; Oed, A. (Institut Max von Laue - Paul Langevin, 38 - Grenoble (France)); Barreau, G.; Doan, T.P.; Leroux, B.; Sicre, A. (Institut Max von Laue - Paul Langevin, 38 - Grenoble (France)); Asghar, M. (Universite des Sciences et de la Technologie Houari Boumedienne, Algiers (Algeria). Inst. de Physique); Goennenwein, F. (Tuebingen Univ. (Germany, F.R.))

    1989-10-09

    The COSI FAN TUTTE spectrometer has been used to measure for the first time in one go the mass-charge-energy correlations for well-resolved light group masses for {sup 229}Th(n{sub th},f). About 4.8x10{sup 5} events were collected in a {approx equal} 3 months run. The global mass distribution shows structures and the distribution for E{sub L}=(112+-0.5) MeV is dominated by mass number A{sub L}=86 and 96. The mean kinetic energy shows strong fluctuations as a function of the light fragment mass A{sub L}. The mean proton odd-even effects in yields and energy are {delta}p=(40.0+-1.0)% and {delta}E{sub TKE}{sup o-e}=(1.35+-0.17) MeV, respectively. The {delta}p(E{sub L}) varies by a factor of {approx equal} 3 for E{sub L}=92 to 107 MeV with a plateau for E{sub L}{approx equal} 96 to 103 MeV. The mean neutron odd-even effect is {delta}n=(1.95+-0.5)%. The mean value of the conditional variance is <{sigma}{sup 2}(Zvertical strokeA)>=(0.33+-0.02) and it varies little with energy. The conditional variance seems to decrease as one goes from {sup 252}Cf to {sup 230}Th. These data are discussed in the context of existing results on other nuclei. (orig.).

  11. Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty.

    Directory of Open Access Journals (Sweden)

    Signe Sloth Mogensen

    Full Text Available UNLABELLED: Central precocious puberty may result from organic brain lesions, but is most frequently of idiopathic origin. Clinical or biochemical factors which could predict a pathological brain MRI in girls with CPP have been searched for. With the recent decline in age at pubertal onset among US and European girls, it has been suggested that only girls with CPP below 6 years of age should have brain MRI performed. OBJECTIVE: To evaluate the outcome of brain MRI in girls referred with early signs of puberty in relation to age at presentation as well as clinical and biochemical parameters. METHOD: A single-center study of 229 consecutive girls with early or precocious puberty who had brain imaging performed. We evaluated medical history, clinical and biochemical factors, and four groups were defined based on the outcome of their MRI. RESULTS: Thirteen out of 208 (6.3% girls with precocious puberty, but no other sign of CNS symptoms, had a pathological brain MRI. Importantly, all 13 girls were above 6 years of age, and 6 girls were even 8-9 years old. Twenty girls (9.6% had incidental findings on brain MRI. Furthermore, 21 girls had known CNS pathology at time of evaluation. Basal LH was significantly higher in girls with newly diagnosed CNS pathology compared to girls with a non-pathological MRI (p = 0.025; no cut of value was found as values overlapped. CONCLUSION: A high frequency of 6-8 year old girls with precocious puberty in our study had a pathological brain MRI, which could not be predicted from any clinical nor biochemical parameters. Thus, we believe that girls with precocious pubertal development of central origin before 8 years of age should continue to be examined by a brain MRI.

  12. 烟草根际铁载体产生菌G-229-21T的筛选、鉴定及拮抗机理%Screening, identification and antagonistic activity of a siderophore-producing bacteria G-229-21T from rhizosphere of tobacco

    Institute of Scientific and Technical Information of China (English)

    田方; 丁延芹; 朱辉; 姚良同; 靳奉理; 杜秉海

    2008-01-01

    [目的]从烟草根际筛选烟草疫霉[Phytophthora parasitica var.nicotianae(Breda de Hann)Tucker]拮抗菌,探索其拮抗机理.[方法]限铁(2.0 μmol/L FeCl3)蔗糖-天冬酰胺平板对峙法筛选烟草疫霉拮抗菌;刃天青(CAS)法检测其铁载体的产生及其对铁离子的亲和能力.结合形态、生理生化、16s rRNA序列同源性和系统发育分析及种特异性分子法对其进行鉴定.XAD-2吸附层析法提取其铁载体,分光光度法检测其铁载体类型.不同铁离子浓度下,比较其铁载体对烟草疫霉的抑制作用.[结果]我们筛选到一株限铁条件下烟草疫霉拮抗菌G-229-21T,该菌产生高亲和力铁载体,被初步鉴定为Pseudomonas mediterranea.该菌产生的羧酸型铁载体,在低铁条件下(0.16μmol/L~10μmol/L,FeCl3)对烟草疫霉的抑制率达92.3%以上,而在富铁条件下(100 μmol/L FeCl3)抑制率仅为2.0%.[结论]首次报道P. mediterranea G-229-21T产生高亲和力羧酸型铁载体,该铁载体在低铁条件下对烟草疫霉有显著的抑制作用.

  13. The effect of lance geometry and carbon coating of silicon lances on propidium iodide uptake in lance array nanoinjection of HeLa 229 cells

    Science.gov (United States)

    Sessions, John W.; Lindstrom, Dallin L.; Hanks, Brad W.; Hope, Sandra; Jensen, Brian D.

    2016-04-01

    Connecting technology to biologic discovery is a core focus of non-viral gene therapy biotechnologies. One approach that leverages both the physical and electrical function of microelectromechanical systems (MEMS) in cellular engineering is a technology previously described as lance array nanoinjection (LAN). In brief, LAN consists of a silicon chip measuring 2 cm by 2 cm that has been etched to contain an array of 10 μm tall, solid lances that are spaced every 10 μm in a grid pattern. This array of lances is used to physically penetrate hundreds of thousands of cells simultaneously and to then electrically deliver molecular loads into cells. In this present work, two variables related to the microfabrication of the silicon lances, namely lance geometry and coating, are investigated. The purpose of both experimental variables is to assess these parameters’ effect on propidium iodide (PI), a cell membrane impermeable dye, uptake to injected HeLa 229 cells. For the lance geometry experimentation, three different microfabricated lance geometries were used which include a flat/narrow (FN, 1 μm diameter), flat/wide (FW, 2-2.5 μm diameter), and pointed (P, 1 μm diameter) lance geometries. From these tests, it was shown that the FN lances had a slightly better cell viability rate of 91.73% and that the P lances had the best PI uptake rate of 75.08%. For the lance coating experimentation, two different lances were fabricated, both silicon etched lances with some being carbon coated (CC) in a  <100 nm layer of carbon and the other lances being non-coated (Si). Results from this experiment showed no significant difference between lance types at three different nanoinjection protocols (0V, +1.5V DC, and  +5V Pulsed) for both cell viability and PI uptake rates. One exception to this is the comparison of CC/5V Pul and Si/5V Pul samples, where the CC/5V Pul samples had a cell viability rate 5% higher. Both outcomes were unexpected and reveal how to better

  14. HIV antibody preliminary screening in 113 229 inpatients%113229例住院患者 HIV 抗体初筛结果分析

    Institute of Scientific and Technical Information of China (English)

    王梅芬; 王庆芳; 刘家田; 李建丽; 王万海

    2014-01-01

    目的:了解某大型医院住院患者人类免疫缺陷病毒( HIV)抗体初筛阳性率及其在临床科室中分布情况。方法对113229例住院患者进行HIV抗体初筛检测,比较不同性别患者的阳性率,分析HIV抗体阳性患者在不同科室的分布情况。结果 HIV抗体初筛阳性152例,阳性率为0.134%;其中男91例(0.161%),女61例(0.107%),不同性别间阳性率比较差异有统计学意义(P<0.05)。 HIV抗体初筛阳性患者分布于20个科室,其中高发科室有耳鼻喉科、骨科、妇科、泌尿外科、普外科、神经内科、皮肤科、肿瘤科、眼科。这些科室的HIV抗体初筛阳性者占总筛查阳性的67.1%。结论住院患者中存在较高的HIV抗体初筛阳性率,且科室分布广泛。%Objective To investigate the positive rate of HIV antibody preliminary screening and the distribution of the clinical departments in general hospital inpatients.Methods HIV antibody preliminary screening detection was conducted in 113 229 cases of patients.The positive rate between different genders was compared , and the distribution of patients with positive HIV antibody in different departments was analyzed.Results Totally 152 plasma samples were positive by the antibody screening test for HIV, and the positive rate was 0.134%, including 91 males and 61 females (P<0.05).The 152 positive cases covered 20 clinical departments and the major clinical departments included otolaryngological department, orthopaedics department, gy-naecology department, urology department, surgery department, neurology department, dermatological department, oncology de-partment and ophthalmology department.The patients with positive HIV antibody undergoing preliminary screening of these de-partments accounted for 67.1%of the total screening.Conclusion The positive rate of HIV antibody screening among inpatients in our hospital is high with a wide range of department

  15. Genes Expression in Response to Re-watering after Drought Stress in Shaan 229 and Characterization of Ethylene Receptor Genes (TaERS) in Wheat%陕229干旱复水诱导基因表达及小麦乙烯受体(TaERS)基因特征分析

    Institute of Scientific and Technical Information of China (English)

    张宏; 陈锐; 黄林周; 胡银岗

    2012-01-01

    为了解小麦响应水分胁迫后复水条件下的基因表达特征,以小麦(Triticum aestivum L.)主栽品种陕229的3叶1心期幼苗为材料,采用消减杂交技术,构建了干旱复水条件下的SSH-cDNA表达文库.从消减文库中随机挑选59个插入片段大于400bp的阳性克隆测序,去除冗余序列和嵌合序列后,获得高质量EST序列32条(GenBank登录号为ES466767~ES466798).序列比对分析表明,小麦干旱后复水的基因表达与植物对其他非生物胁迫的响应具有交叉性;17条EST序列与已知编码蛋白的基因同源性较高,涉及植物的信号传导、能量代谢、转录调控等方面;其他序列为新的EST.以其中一个与乙烯受体基因(ERS)同源性较高的EST序列为基础,采用同源克隆及RACE技术从小麦中分离了4个乙烯受体基因的全长cDNA序列,长度分别为2090、2271、2216和1886bp.4个全长cDNA序列所编码氨基酸序列的同源性极高(99%以上),且均具有ERS典型的GAF、HisKA和HATPase-c跨膜结构,分别命名为TaERS1(HM347272),TaERS2(HM601437),TaERS3(HM601438)和TaERS4(HQ111523).植物ERS氨基酸序列多重比较表明,小麦与水稻的相似性最高(93%);TaERS基因的全长cDNA序列间比较共发现SNP位点23个.定量PCR表达分析显示,小麦TaERS家族基因参与了小麦植株响应水分胁迫和复水的调控机制.研究结果有助于进一步认识小麦干旱后复水的基因表达谱和小麦水分高效利用机制,探索小麦乙烯受体在水分高效利用中的作用.%To explore more genes for the improvement of drought-tolerance and water use efficiency in crops, the differential gene expression during re-watering after serious drought stress in common wheat (Triticumaestivum L.) was investigated by constructing SSH-cDNA library with the seedlings of Shaan 229 as materials. A total of 59 positive clones with insertions more than 400 bp were randomly picked from the library and sequenced. Then

  16. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  17. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  18. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  19. The release of dissolved actinium to the ocean: A global comparison of different end-members

    Science.gov (United States)

    Geibert, W.; Charette, M.; Kim, G.; Moore, W.S.; Street, J.; Young, M.; Paytan, A.

    2008-01-01

    The measurement of short-lived 223Ra often involves a second measurement for supported activities, which represents 227Ac in the sample. Here we exploit this fact, presenting a set of 284 values on the oceanic distribution of 227Ac, which was collected when analyzing water samples for short-lived radium isotopes by the radium delayed coincidence counting system. The present work compiles 227Ac data from coastal regions all over the northern hemisphere, including values from ground water, from estuaries and lagoons, and from marine end-members. Deep-sea samples from a continental slope off Puerto Rico and from an active vent site near Hawaii complete the overview of 227Ac near its potential sources. The average 227Ac activities of nearshore marine end-members range from 0.4??dpm m- 3 at the Gulf of Mexico to 3.0??dpm m- 3 in the coastal waters of the Korean Strait. In analogy to 228Ra, we find the extension of adjacent shelf regions to play a substantial role for 227Ac activities, although less pronounced than for radium, due to its weaker shelf source. Based on previously published values, we calculate an open ocean 227Ac inventory of 1.35 * 1018??dpm 227Acex in the ocean, which corresponds to 37??moles, or 8.4??kg. This implies a flux of 127??dpm m-2 y- 1 from the deep-sea floor. For the shelf regions, we obtain a global inventory of 227Ac of 4.5 * 1015??dpm, which cannot be converted directly into a flux value, as the regional loss term of 227Ac to the open ocean would have to be included. Ac has so far been considered to behave similarly to Ra in the marine environment, with the exception of a strong Ac source in the deep-sea due to 231Paex. Here, we present evidence of geochemical differences between Ac, which is retained in a warm vent system, and Ra, which is readily released [Moore, W.S., Ussler, W. and Paull, C.K., 2008-this issue. Short-lived radium isotopes in the Hawaiian margin: Evidence for large fluid fluxes through the Puna Ridge. Marine Chemistry]. Another potential mechanism of producing deviations in 227Ac/228Ra and daughter isotope ratios from the expected production value of lithogenic material is observed at reducing environments, where enrichment in uranium may occur. The presented data here may serve as a reference for including 227Ac in circulation models, and the overview provides values for some end-members that contribute to the global Ac distribution. ?? 2007 Elsevier B.V. All rights reserved.

  20. 下肢动脉硬化闭塞症合并无症状性颈动脉狭窄229例%Peripheral arterial occlusive disease complicating asymptomatic carotid stenosis

    Institute of Scientific and Technical Information of China (English)

    张华; 潘仲杰; 赵奇; 栗力

    2014-01-01

    Objective To evaluate the incidence of asymptomatic carotid stenosis (ACS) in patients with peripheral arterial occlusive disease (PAOD) who was admitted for revascularization.Methods 229 PAOD patients were evaluated by carotid ultrasound preoperatively and divided into severe ACS group (ACS ≥ 70%) and non severe ACS group (ACS < 70%).The clinical characteristics and associated risk factors of the two groups were analyzed.Results The incidence of severe ACS was 19.7%,age,blood pressure,total cholesterol and fibrinogen levels in severe ACS group were significantly higher than those in non-severe ACS group (P < 0.05),the more severe the symptoms of PAOD are,the higher is the incidence of severe ACS.Age,hypertension and hypercholesterolemia were all predictors of severe ACS.Conclusions The severity of PAOD is positively correlated with the incidence of severe ACS.Age,hypertension and hypercholesterolemia are independent risk factors for severe ACS.%目的 总结下肢动脉硬化闭塞症(peripheral arterial occlusive disease,PAOD)需血管重建术患者无症状重度颈动脉狭窄(asymptomatic carotid stenosis,ACS)发生率、临床特点及其相关危险因素,探讨PAOD术前行颈动脉超声筛查重度ACS的临床价值.方法 回顾性分析229例需血管重建术治疗的重度PAOD患者的临床资料,术前均行颈动脉超声检查筛查ACS,并将PAOD患者分为重度ACS组(ACS ≥70%)和非重度ACS组(ACS< 70%),对2组患者临床特点及相关危险因素进行分析.结果 229例患者中,重度ACS发生率为19.7%;重度ACS组患者年龄、血压、总胆固醇和纤维蛋白原水平明显高于非重度ACS组,差异有统计学意义(P<0.05);PAOD症状越重的患者重度ACS的发生率越高;多因素Logistic回归分析显示高龄、高血压以及高胆固醇血症是重度ACS预测指标.结论 PAOD症状严重程度与重度ACS发生率呈正相关且高龄、高血压以及高胆固醇血症是重度ACS的独立危险因素.

  1. Infection status of coronavirus type HCOV-OC43, type HCOV-229E, type HCOV-HKU1 and type HCOV-NL63 in Guizhou Province%贵州省冠状病毒感染状况

    Institute of Scientific and Technical Information of China (English)

    庄丽; 任丽娟; 付琳

    2012-01-01

    目的 对贵州省呼吸道症候群病例的冠状病毒HCOV-OC43型、HCOV-229E型、HCOV-HKU1型和HCOV-NL63型的感染状况进行检测.方法 提取病毒核酸RNA,通过实时荧光定量PCR(Real-Time PCR)方法检测冠状病毒.结果 在收集到的282份呼吸道症侯群病例标本中,冠状病毒HCOV-OC43型阳性有11份.其余均为阴性.其它三个型别未检出.结论 贵州省呼吸道症侯群病例中存在冠状病毒感染,其型别为冠状病毒HCOV-OC43型.阳性率为3.9%.

  2. QTL Information Table: 229 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available ). Characterization of the main effects, epistatic effects and their environmental interactions of QTLs on the genetic basis of yield traits in rice. Theor Appl Genet 105, 248-257. ...

  3. 30 CFR 229.124 - Documentation standards.

    Science.gov (United States)

    2010-07-01

    ... standards. In particular, detailed workpapers must be developed and maintained. (a) Workpapers are defined... scope and detail. As a result, the audit team must determine the best presentation of the workpapers for... able to readily determine their purpose, the nature and scope of the work done, and the...

  4. 47 CFR 24.229 - Frequencies.

    Science.gov (United States)

    2010-10-01

    ... MHz; Pursuant to Amendment of the Commission's Rules Regarding Installment Payment Financing for... for mobile/portable station transmissions while the 1990-1995 MHz block shall be used for base...

  5. 22 CFR 229.235 - Statutory amendments.

    Science.gov (United States)

    2010-04-01

    ... legal abortion. Accordingly, subject to paragraph (d)(1) of this section, no person shall be excluded... received, or is seeking, a legal abortion, or any benefit or service related to a legal abortion. ... abortion. Medical procedures, benefits, services, and the use of facilities, necessary to save the life of...

  6. 22 CFR 229.300 - Admission.

    Science.gov (United States)

    2010-04-01

    ... predict validly success in the education program or activity in question and alternative tests or criteria... relating to marital or parental status. In determining whether a person satisfies any policy or criterion... apply: (1) Shall not apply any rule concerning the actual or potential parental, family, or...

  7. 29 CFR 779.229 - Other arrangements.

    Science.gov (United States)

    2010-07-01

    ...) advertising; (3) sales promotions; (4) managerial advice; (5) store engineering; (6) accounting systems; (7... an economic unity of related activities for a common business purpose. In that case, the...

  8. 49 CFR 229.27 - Annual tests.

    Science.gov (United States)

    2010-10-01

    ... above the working pressure and the visual return water-flow indicator shall be removed and inspected. (d... crashworthy crash hardened event recorder memory module if the locomotive is so equipped....

  9. Low lying states of Th229

    DEFF Research Database (Denmark)

    Andersen, Torkild; Maack Bisgård, K.; Hansen, P.Gregers

    1961-01-01

    The decay of 1.6 × 105y U233 has been studied by means of a six gap beta-ray spectrometer, a xenon filled proportional counter and scintillation spectrometers. Internal conversion electrons having energies below 100 keV were measured. The mixing ratios for the 42 keV and the 55 keV transitions ag...

  10. 7 CFR 2.29 - Chief Economist.

    Science.gov (United States)

    2010-01-01

    ... appropriate methods of risk assessment and cost-benefit analyses and coordinate and review all risk... the Secretary of Labor and annual numerical limitation on the number of RAWs who may be admitted or... application of hydrogen and fuel cell technology programs for rural communities and agricultural...

  11. 32 CFR 229.3 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., ceremonial structures, artificial mounds, earthworks, fortifications, canals, reservoirs, horticultural... pits, cooking pits, refuse pits, burial pits or graves, hearths, kilns, post molds, wall trenches...

  12. 12 CFR 229.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... ink character recognition line and MICR line mean the numbers, which may include the routing number... Location of MICR Printing, X9.13 (hereinafter ANS X9.13) for an original check and American National... original check; (2) Bears a MICR line that, except as provided under ANS X9.100-140 (unless the Board by...

  13. 22 CFR 229.500 - Employment.

    Science.gov (United States)

    2010-04-01

    ... attendance at any educational institution or entity that admits as students only or predominantly members of... relationship which directly or indirectly has the effect of subjecting employees or students to discrimination..., application of nepotism policies, right of return from layoff, and rehiring; (3) Rates of pay or any other...

  14. 49 CFR 229.135 - Event recorders.

    Science.gov (United States)

    2010-10-01

    ... displaying any of the required elements to the engineer. (1) A lead locomotive originally ordered before... normally occupied by the locomotive engineer. In the case of a brake application or release that is responsive to a command originating from or executed by an on-board computer (e.g., electronic braking system...

  15. 49 CFR 229.5 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... Water Regulations, or water that has been approved for drinking and washing purposes by the pertinent... drinking water is deemed potable water. Powered axle is an axle equipped with a traction device. Power car..., specialized maintenance, or other similar equipment— (1) With one or more propelling motors designed for...

  16. 22 CFR 229.230 - Transition plans.

    Science.gov (United States)

    2010-04-01

    ... Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION... administratively separate unit may submit either a single transition plan applicable to all such units, or a... Secretary of Education, a transition plan shall: (1) State the name, address, and Federal...

  17. 49 CFR 229.109 - Safety valves.

    Science.gov (United States)

    2010-10-01

    ....109 Safety valves. Every steam generator shall be equipped with at least two safety valves that have a combined capacity to prevent an accumulation of pressure of more than five pounds per square inch above the... ends of the safety valve discharge lines shall be located or protected so that discharged steam...

  18. 50 CFR 229.2 - Definitions.

    Science.gov (United States)

    2010-10-01

    ..., or any animal that is released with fishing gear entangling, trailing or perforating any part of the... individual means an individual ascertained by NMFS to be reasonably able, though training or experience,...

  19. 49 CFR 229.45 - General condition.

    Science.gov (United States)

    2010-10-01

    ... endanger the safety of the crew, locomotive or train. These conditions include: insecure attachment of components, including third rail shoes or beams, traction motors and motor gear cases, and fuel tanks; fuel... other structural infirmities of components, including quill drives, axles, gears, pinions,...

  20. 20 CFR 229.48 - Family maximum.

    Science.gov (United States)

    2010-04-01

    ... month on one person's earnings record is limited. This limited amount is called the family maximum. The family maximum used to adjust the social security overall minimum rate is based on the employee's Overall..., when any of the persons entitled to benefits on the insured individual's compensation would, except...

  1. Teaching about Nuclear Disarmament. Fastback 229.

    Science.gov (United States)

    Becker, James, M.

    Background information to help educators teach about nuclear disarmament is presented. There are six sections. The first section, "Nuclear Arms Education: Avoiding the Final Catastrophe," discusses the national priority of preparing for war, militarism as a value, and the mushroom cloud and spaceship earth as symbols of a global age. The second…

  2. 12 CFR 229.3 - Administrative enforcement.

    Science.gov (United States)

    2010-01-01

    ... located in the United States (other than Federal branches, Federal agencies, and insured State branches of... than members of the Federal Reserve System) and insured State branches of foreign banks, by the Board... EFA Act is deemed to be a violation of a requirement imposed under that statute. (2) In addition...

  3. 12 CFR 229.21 - Civil liability.

    Science.gov (United States)

    2010-01-01

    ... state law that supersedes any provision of subpart B, and in connection therewith, subpart A, with... brought in any United States district court or in any other court of competent jurisdiction, and shall be... by an agency charged with monitoring that bank's compliance with the EFA Act and this subpart, or...

  4. 47 CFR 22.229 - Designated entities.

    Science.gov (United States)

    2010-10-01

    ... entrepreneur is an entity that, together with its controlling interests and affiliates, has average annual... entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit...

  5. 22 CFR 229.405 - Housing.

    Science.gov (United States)

    2010-04-01

    ... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education... sex, apply different rules or regulations, impose different fees or requirements, or offer...

  6. Reference: 229 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available nditions, and immediate up-regulation upon day-length extension. These observation...nt of photoperiods or CO, or FLC. These observations suggest that TSF is a new member of the floral pathway

  7. 49 CFR 229.7 - Prohibited acts.

    Science.gov (United States)

    2010-10-01

    ... injury to persons, or has caused death or injury, a penalty not to exceed $100,000 per violation may be... such requirement is subject to a civil penalty of at least $650 and not more than $25,000 per violation, except that: Penalties may be assessed against individuals only for willful violations, and, where...

  8. 22 CFR 229.450 - Athletics.

    Science.gov (United States)

    2010-04-01

    ... such basis. (b) Separate teams. Notwithstanding the requirements of paragraph (a) of this section, a... based upon competitive skill or the activity involved is a contact sport. However, where a recipient operates or sponsors a team in a particular sport for members of one sex but operates or sponsors no such...

  9. Investigation of the Static Longitudinal and Lateral Stability Characteristics of a 0.10-Scale Model of a Three-Stage Configuration of the Scout Research Vehicle at Mach Numbers of 2.29, 2.96, 3.96, and 4.65

    Science.gov (United States)

    Jernell, Lloyd S.

    1961-01-01

    An investigation w a s made i n the Langley Unitary Plan wind tunnel o determine the effects of fin area and the effects of antennas and w iring tunnels on the static longitudinal and lateral stability of a 0 .10- scale model of a three- stage configuration of the Scout vehicle. The tests were performed at Mach numbers of 2.29, 2.96, 3.96, and 4. 65 6 and at Reynolds numbers of about 3.5 X 10 per foot.

  10. 1.5~3岁儿童颜色指认与命名能力的实验研究--基于229名1.5~3岁儿童%Study on Color Recognition and Color Naming Ability of Children Aged from 1. 5 to 3 Years Old

    Institute of Scientific and Technical Information of China (English)

    张远丽

    2015-01-01

    通过对229名1.5~3岁儿童的颜色指认和颜色命名实验发现,与31年前相比,1.5~3岁儿童的颜色命名能力有所提高,个别颜色在某些年龄段存在性别差异,各年龄段颜色指认、命名规律不完全相同,但遵循了柏林和凯提出的颜色认知的基本规律。%The experiment on the color identification and color naming of 229 children aged from 1. 5 to 3 years old shows as follows:compared with children aged from 1. 5 to 3 years old 29 years ago,the childrenˊs color naming ability is improved;individual color gender differences exist in some age groups;laws of color recognition and naming are not ex-actly the same in various age groups but follow the basic law of color cognition proposed by Berlin and Kay.

  11. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  12. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  13. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  14. Avaliação da redução na poluição dos laticínios, a partir da fermentação do soro de leite em etanol pela levedura Kluyveromyces marxianus 229

    Directory of Open Access Journals (Sweden)

    Cleidiane Samara Murari

    2013-08-01

    Full Text Available O soro de leite é um importante subproduto da indústria de laticínios, devido ao seu volume gerado, e pela sua carga poluidora, que quando lançado em corpos receptores d' água sem tratamento prévio, pode gerar sérios danos ao meio ambiente, com uma Demanda Química de Oxigênio (DQO que fica em torno de 60.000 mg/L. A bioconversão da lactose do soro de leite em etanol por micro-organismos capazes de metabolizar tal dissacarídeo, representa uma alternativa promissora para o tratamento e disposição do mesmo, pois além de se obter uma redução expressiva da DQO, é possível gerar um bioproduto de importância comercial, como no caso etanol. Neste contexto, o objetivo do trabalho foi avaliar a produção de etanol a partir da fermentação do soro de leite in natura pela levedura Kluyveromyces marxianus 229, visando à redução do seu potencial poluidor e conseqüente menor impacto ao meio ambiente, e a geração de um subproduto de maior valor comercial. A levedura Kluyveromyces marxianus 229, foi utilizada, para a fermentação do soro de leite, obtido após a produção do queijo Minas Frescal. Após 12 horas de fermentação do soro, obteve-se uma produção máxima de etanol de 18,70 g/L, e um rendimento etanólico teórico de 64,10%. Já em relação a redução teor de matéria orgânica (DQO, esta foi de 76,50%, com 48 horas de fermentação. Tais resultados mostram que a fermentação do soro pela levedura do gênero Kluyveromyces ssp é uma alternativa eficaz para reduzir seu teor de matéria orgânica, além de gerar um produto de elevado interesse comercial. Palavras-chave levedura, bioprocessos, DQO, meio ambiente

  15. 17 CFR 229.402 - (Item 402) Executive compensation.

    Science.gov (United States)

    2010-04-01

    ... achievement of the registrant's long-term goals, management's exposure to downside equity performance risk... this Item: (i) The term stock means instruments such as common stock, restricted stock, restricted... instruments that do not have option-like features, and the term option means instruments such as stock...

  16. 17 CFR 229.1111 - (Item 1111) Pool assets.

    Science.gov (United States)

    2010-04-01

    ..., it is not necessary to provide details of the laws in each jurisdiction. Even in that case, a... appropriate introductory and explanatory information to introduce the characteristics, the methodology used in... percentage for each of the last five years. (E) Principal business, occupations and professions carried on in...

  17. 17 CFR 229.1107 - (Item 1107) Issuing entities.

    Science.gov (United States)

    2010-04-01

    ... issue or invest in additional securities, to borrow money or to make loans to other persons. Describe... issuing entity as well as the creation (and perfection and priority status) of any security interest in... material terms of any agreement providing for such sale, transfer or creation of a security interest. File...

  18. 32 CFR 229.8 - Issuance of permits.

    Science.gov (United States)

    2010-07-01

    ..., education, and/or experience, and possesses demonstrable competence in archaeological theory and methods..., administration, or management, including at least 4 months experience and/or specialized training in the kind of... knowledge in the public interest, which may include but need not be limited to, scientific or scholarly...

  19. 20 CFR 229.81 - Refusal to accept vocational rehabilitation.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Refusal to accept vocational rehabilitation... Refusal to accept vocational rehabilitation. The DIB O/M is not payable for any month in which the disabled employee refuses, without good reason, to accept vocational rehabilitation services...

  20. 17 CFR 229.102 - (Item 102) Description of property.

    Science.gov (United States)

    2010-04-01

    ... whether properties should be described, the registrant should take into account both quantitative and... concerning these matters shall be furnished; and B. Appropriate maps shall be used to disclose location data... relating to such acquisition. 6. The definitions in § 210.4-10(a) of Regulation S-X shall apply to this...

  1. 17 CFR 229.103 - (Item 103) Legal proceedings.

    Science.gov (United States)

    2010-04-01

    ... INSTRUCTIONS FOR FILING FORMS UNDER SECURITIES ACT OF 1933, SECURITIES EXCHANGE ACT OF 1934 AND ENERGY POLICY... involves potential monetary sanctions, capital expenditures, deferred charges or charges to income and the... proceeding and such proceeding involves potential monetary sanctions, unless the registrant reasonably...

  2. 17 CFR 229.301 - (Item 301) Selected financial data.

    Science.gov (United States)

    2010-04-01

    ... the accounting principles used in its primary financial statements but in such case shall present this... accounting principles and Regulation S-X made pursuant to Rule 4-01 of Regulation S-X (§ 210.4-01 of this... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 301) Selected...

  3. 17 CFR 229.1202 - (Item 1202) Disclosure of reserves.

    Science.gov (United States)

    2010-04-01

    ..., including standardized futures prices or management's own forecasts. (3) If the registrant provides...) Preparation of reserves estimates or reserves audit. Disclose and describe the internal controls...

  4. 49 CFR 238.229 - Safety appliances-general.

    Science.gov (United States)

    2010-10-01

    ... accordance with the welding procedures contained in APTA Standard SS-C&S-020-03—Standard for Passenger Rail....21. The Director of the Federal Register approves incorporation by reference of the APTA Standard...

  5. Dicty_cDB: AFL229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 6 5', mRNA sequence. 58 2e-04 1 CK232366 |CK232366.1 ILLUMIGEN_MCQ_4000 Katze_MMPL2 Macaca mulatta cDNA 5' similar to human RBBP4...) RecName: Full=Histone-binding protein RBBP4; AltName: F... 212 6e-54 AK299251_1( AK299251 |pid:none) Homo ...o... 212 6e-54 ( O93377 ) RecName: Full=Histone-binding protein RBBP4-A; AltName:... 212 6e-54 ( Q09028 ) Re...cName: Full=Histone-binding protein RBBP4; AltName: F... 212 6e-54 (Q5M7K4) RecNa...me: Full=Histone-binding protein RBBP4; AltName: F... 212 6e-54 protein update 2009. 4.25 PSORT psg: 0.66 gv

  6. 22 CFR 229.415 - Access to course offerings.

    Science.gov (United States)

    2010-04-01

    ....415 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex... a single standard of measuring skill or progress in a physical education class has an adverse...

  7. 17 CFR 229.901 - (Item 901) Definitions.

    Science.gov (United States)

    2010-04-01

    ... succeeds to the interests of a general partner or sponsor, if: (A) Such action is approved by not less than... minimum closing price of $2.00 or more for a majority of the business days during the preceding three-month period and a six-month minimum average daily trading volume of 1,000 shares; (vi) A transaction in...

  8. 50 CFR 229.35 - Bottlenose Dolphin Take Reduction Plan.

    Science.gov (United States)

    2010-10-01

    ... Regulations for Preventing Collisions at Sea, 1972), as depicted or noted on nautical charts published by the... is all tidal and marine waters within 6.5 nautical miles (12 km) of shore from the New York-New Jersey border southward to Cape Hatteras, North Carolina, and within 14.6 nautical miles (27 km) of...

  9. 40 CFR 229.3 - Transportation and disposal of vessels.

    Science.gov (United States)

    2010-07-01

    ... of these vessels shall take place in a site designated on current nautical charts for the disposal of... week, of the exact coordinates of the disposal site so that it may be marked on appropriate charts....

  10. 49 CFR 229.51 - Aluminum main reservoirs.

    Science.gov (United States)

    2010-10-01

    ... in accordance with American Society of Mechnical Engineers (ASME) Specification SB-209, as defined in the “ASME Boiler and Pressure Vessel Code” (1971 edition), section II, Part B, page 123, with a... and fabricated in accordance with the “ASME Boiler and Pressure Vessel Code,” section VIII, Division...

  11. 12 CFR Appendix E to Part 229 - Commentary

    Science.gov (United States)

    2010-01-01

    ... the depositary bank to the paying bank. One way to speed the return process is to prepare the returned... government is defined to include a city, county, parish, town, township, village, or other general purpose...

  12. Dicty_cDB: AHB229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 751 |pid:none) HIV-1 isolate pt6w20 from Italy in... 47 0.001 DQ354122_2( DQ354122 |pid:none) HIV-1 isolate ...002 EU908759_1( EU908759 |pid:none) HIV-1 isolate pt4bl from Italy int... 46 0.00

  13. Dicty_cDB: SFH229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nd,single read. 1013 0.0 1 AW395348 |AW395348.1 sh46h12.y1 Gm-c1017 Glycine max cDNA clone GENOME SYSTEMS...27021.1 sae30b10.y1 Gm-c1067 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1067-4292 5' similar to TR:...6 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1086-1674 5' similar to TR:...Gm-c1080 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1080-173 5' similar to TR:Q9XHH0 Q9XHH0 ACETOAC...-c1056 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1056-1716 5' similar to TR:Q9XHH0 Q9XHH0 ACETOACE

  14. 49 CFR 229.125 - Headlights and auxiliary lights.

    Science.gov (United States)

    2010-10-01

    ... shall have a headlight that produces a peak intensity of at least 200,000 candela. If a locomotive or... its rear a headlight that produces at least 200,000 candela. Each headlight shall be arranged to... headlight, the single lamp shall produce a peak intensity of at least 200,000 candela. The following lamps...

  15. 48 CFR 252.229-7005 - Tax exemptions (Spain).

    Science.gov (United States)

    2010-10-01

    ... following excise, luxury, and transaction taxes: (1) Derechos de Aduana (Customs Duties). (2) Impuesto de... Transfer Tax). (4) Impuesto Sobre el Lujo (Luxury Tax). (5) Actos Juridocos Documentados (Legal...

  16. Dicty_cDB: VSD229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available y1 Plasmodium falciparum 3D7 asexual cDNA Plasmodium falciparum cDNA 5' similar to SW:RAN_PLAFA P38545 GTP-B...2.1 PfESToaa31a10.y1 Plasmodium falciparum 3D7 asexual cDNA Plasmodium falciparum cDNA 5' similar to SW:RAN_...29h11.y1 Plasmodium falciparum 3D7 asexual cDNA Plasmodium falciparum cDNA 5' sim...2295.1 PfESToaa94h01.y1 Plasmodium falciparum 3D7 asexual cDNA Plasmodium falciparum cDNA 5' similar to SW:R

  17. Dicty_cDB: SSL229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1 Pan troglodytes chromosome UNK clone RP43-2A11, WORKING DRAFT SEQUENCE, 5 unordered pieces. 52 0.16 5 AC02...4666 |AC024666.2 Homo sapiens chromosome 3 clone RP11-698E5 map 3, WORKING DRAFT ... DNA, chromosome 6, PAC clone:P0532H03, WORKING DRAFT SEQUENCE, 1 ordered pieces. 44 0.33 3 AZ953443 |AZ9534...EQUENCING IN PROGRESS ***, 53 unordered pieces. 40 0.64 3 AC016808 |AC016808.4 Homo sapiens clone RP11-11G12, WORK...mosome 18q22 clone:RP11-831H17, WORKING DRAFT SEQUENCE, 21 unordered pieces. 42 0

  18. Dicty_cDB: SFF229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 60 6e-06 2 CA813481 |CA813481.1 CA48LN10IF-E8 Cabernet Sauvignon Leaf - CA48LN Vitis vinifera cDNA clone CA...48LN10IF-E8 5', mRNA sequence. 60 7e-06 2 CB341828 |CB341828.2 CA32EN0002_IIIbF_E01 Caberne...lanum tuberosum cDNA clone POADC22 5' end, mRNA sequence. 42 4e-05 2 CF514038 |CF514038.1 CAbud0007_IVF_G07 Vitis vinifera cv. cabern

  19. Dicty_cDB: SHF229 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ILIDGKPCTQXEINIHTYSSLTCNVTNYDEMLK YNYSNTKFNISISVDGQYFIAQIFQFKYESDN*l**k*virisk*nvyryccnynifsin flcy*ntg*kiy*...NKP TIDDQGNITIQGSNLYNTQI--- ---IHQILIKLLLITIYGTSFGDANLEILIDGKPCTQXEINIHTYSSLTCNVTNYDEMLK YNYSNTKFNISISVDGQYFIAQIFQFKYESDN*l**k*viris

  20. 7 CFR 1220.229 - Influencing governmental action.

    Science.gov (United States)

    2010-01-01

    ... government, or any political subdivision thereof. (b) The prohibition in paragraph (a) of this section shall... communication to appropriate government officials of information relating to the conduct, implementation, or... political subdivision thereof....

  1. 17 CFR 229.407 - (Item 407) Corporate governance.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 407) Corporate....407 (Item 407) Corporate governance. (a) Director independence. Identify each director and, when the... independent accountant's communications with the audit committee concerning independence, and has...

  2. 17 CFR 229.909 - (Item 909) Conflicts of interest.

    Science.gov (United States)

    2010-04-01

    ...) Conflicts of interest. (a) Briefly describe the general partner's fiduciary duties to each partnership... material relationship between the representative or its affiliates and: (A) The general partner, sponsor... contemplated and any compensation received or to be received as a result of such relationship; (vi) Describe in...

  3. 17 CFR 229.601 - (Item 601) Exhibits.

    Science.gov (United States)

    2010-04-01

    ... servicing criteria for asset-backed securities X (35) Servicer compliance statement X (36) through (98) N/A.... All of the reports on assessment of compliance with servicing criteria for asset-backed securities and... compliance with servicing criteria for asset-backed securities. Each report on assessment of compliance with...

  4. 17 CFR 229.1115 - (Item 1115) Certain derivatives instruments.

    Science.gov (United States)

    2010-04-01

    ... 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation... enhancement related to the pool assets or the asset-backed securities. For purposes of this section, the... asset-backed securities, the “significance percentage” is the percentage that the amount of the...

  5. 17 CFR 229.512 - (Item 512) Undertakings.

    Science.gov (United States)

    2010-04-01

    ... under section 305(b)(2) of the Act. (k) Filings regarding asset-backed securities incorporating by... be deemed to be the initial bona fide offering thereof. (l) Filings regarding asset-backed securities...) and (a)(1)(ii) do not apply if the registration statement is for an offering of asset-backed...

  6. 17 CFR 229.504 - (Item 504) Use of proceeds.

    Science.gov (United States)

    2010-04-01

    ... financial statements of the business to be acquired to be included, the description of the business to be... a brief outline of any program of construction or addition of equipment. Consideration should be... of registrant's financial condition and results of operations, such as liquidity and capital...

  7. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  8. http://www.e-journall.org/2376905x-2-29/

    Directory of Open Access Journals (Sweden)

    Zainab Abolfazli Khonbi

    2015-08-01

    Full Text Available The present research contributes to an increased understanding of the potential relationships between multiple intelligences and the choice and frequency of use of language learning strategies. Forty-one EFL students from Urmia University (Iran completed Oxford’s (1990a Strategy Inventory for Language Learning and the McKenzie (1999 Multiple Intelligences Inventory. Data analyses revealed a moderately positive relationship between the participants’ multiple intelligences and language learning strategy use (r = .58. Pearson Product-Moment correlation also showed medium-to-large positive relationships within and among the categories of multiple intelligences and the types of language learning strategies. Implications of this study for EFL education are discussed, and suggestions to improve students’ performance are provided.

  9. 48 CFR 52.229-10 - State of New Mexico Gross Receipts and Compensating Tax.

    Science.gov (United States)

    2010-10-01

    ... Contractor shall submit applications for Nontaxable Transaction Certificates, Form CSR-3C, to the State of.... When the Type 15 Nontaxable Transaction Certificate is issued by the Revenue Division, the Contractor... (*__) and the New Mexico Taxation and Revenue Department. (d) The Contractor shall provide Type...

  10. The Expression of the Hepatocyte SLAMF3 (CD229) Receptor Enhances the Hepatitis C Virus Infection

    Science.gov (United States)

    Cartier, Flora; Marcq, Ingrid; Douam, Florian; Ossart, Christèle; Regnier, Aline; Debuysscher, Véronique; Lavillette, Dimitri; Bouhlal, Hicham

    2014-01-01

    Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. We recently characterized for the first time the expression of Signaling Lymphocyte Activating Molecule 3 (SLAMF3) in human hepatocytes and here, we report that SLAMF3 interacts with the HCV viral protein E2 and is implicated in HCV entry process. We found a strong correlation between SLAMF3 expression level and hepatocyte susceptibility to HCV infection. The use of specific siRNAs to down-modulate SLAMF3 expression and SLAMF3-blocking antibodies both decreased the hepatocytes susceptibility to HCV infection. Moreover, SLAMF3 over-expression significantly increased susceptibility to HCV infection. Interestingly, experiments with peptides derived from each SLAMF3 domain showed that the first N-terminal extracellular domain is essential for interaction with HCV particles. Finally, we showed that recombinant HCV envelop protein E2 can bind SLAMF3 and that anti-SLAMF3 antibodies inhibited specifically this interaction. Overall, our results revealed that SLAMF3 plays a role during HCV entry, likely by enhancing entry of viral particle within hepatocytes. PMID:24927415

  11. 17 CFR 229.1014 - (Item 1014) Fairness of the going-private transaction.

    Science.gov (United States)

    2010-04-01

    ... transaction is fair or unfair to unaffiliated security holders. If any director dissented to or abstained from... referred to in paragraphs (c), (d) and (e) of this section and whether the consideration offered...

  12. 17 CFR 229.910 - (Item 910) Fairness of the transaction.

    Science.gov (United States)

    2010-04-01

    ... transaction is fair or unfair to investors and the reasons for such belief. Such discussion must address the... value of the consideration to be received in the roll-up transaction to the value of the consideration... the general partner that may affect materially the value of the consideration to be received...

  13. 17 CFR 229.911 - (Item 911) Reports, opinions and appraisals.

    Science.gov (United States)

    2010-04-01

    ... including, but not limited to, any such report, opinion or appraisal relating to the consideration or the fairness of the consideration to be offered to investors in connection with the roll-up transaction or the... during the past two years or is mutually understood to be contemplated and any compensation received...

  14. 17 CFR 229.1204 - (Item 1204) Oil and gas production, production prices and production costs.

    Science.gov (United States)

    2010-04-01

    ... price (including transfers) per unit of oil, gas and other products produced; and (2) The average... conversion to synthetic oil or gas, the product's production, transfer prices, and production costs should be disclosed separately from all other products. Instruction 4 to Item 1204: The transfer price of oil and...

  15. 17 CFR 229.305 - (Item 305) Quantitative and qualitative disclosures about market risk.

    Science.gov (United States)

    2010-04-01

    ... millions) Long-term Debt: Fixed Rate ($US) $XXX $XXX $XXX $XXX $XXX $XXX $XXX $XXX Average interest rate X.X% X.X% X.X% X.X% X.X% X.X% X.X% Fixed Rate (DM) XXX XXX XXX XXX XXX XXX XXX XXX Average interest rate X.X% X.X% X.X% X.X% X.X% X.X% X.X% Variable Rate ($US) XXX......

  16. 48 CFR 1652.229-70 - Taxes-Foreign Negotiated benefits contracts.

    Science.gov (United States)

    2010-10-01

    ... in this clause, include fees and charges for doing business that are levied by the government of the... security or other employment taxes, net income and franchise taxes, excess profits taxes, capital...

  17. 48 CFR 52.229-6 - Taxes-Foreign Fixed-Price Contracts.

    Science.gov (United States)

    2010-10-01

    ... and taxes include fees and charges for doing business that are levied by the government of the country... social security or other employment taxes, net income and franchise taxes, excess profits taxes,...

  18. SU-E-T-229: Craniospinal Radiotherapy Planning with VMAT, Two First Years Experience

    Energy Technology Data Exchange (ETDEWEB)

    Lliso, F; Carmona, V; Gimeno, J; Candela-Juan, C; Bautista, J [La Fe University and Polytechnic Hospital, Valencia, Valencia (Spain); Richart, J [ITIC, Hospital Clinica Benidorm, Benidorm, Alicante (Spain); Perez-Calatayud, J [La Fe University and Polytechnic Hospital, Valencia, Valencia (Spain); ITIC, Hospital Clinica Benidorm, Benidorm, Alicante (Spain)

    2015-06-15

    Purpose: To describe how we moved to VMAT in the craniospinal radiotherapy planning process, the actual procedure details, and the results for the patients treated. Methods: Twelve patients underwent craniospinal irradiation with the new procedure, based on the paper by Lee et al. (IJROBP 82, 2012), with some additional modifications. Patients were treated in supine position in Varian Clinac iX linacs with 6 MV RapidArc; prescription doses ranged from 23.4 to 40 Gy (13 to 20 fractions); depending on the PTV length, 2 or 3 isocenters were used, all coordinates being equal except the longitudinal one, setting a few centimeter-long overlapping region; 2 arcs (RA) sharing isocentre for the cranial region, RA1 encompassing cranium and superior spinal region, and RA2 intended to improve conformity, only for cranium; for spine, 1 or 2 isocenters were employed; optimization was performed with Eclipse (V 13.0) using AAA algorithm, establishing sets of optimization parameters to give high conformity while sparing OAR. In pediatric patients, homogeneous irradiation of the vertebrae was also required.Conformity (CI) and heterogeneity (HI) indices (same as Lee et al.), and mean and maximum doses for OAR were calculated. Several pre-treatment verification methods were used: Octavius4D (PTW) for each isocentre, point dose at the junction region, Portal Dosimetry (when possible), and independent MU verification software (Diamond, PTW). Results: CI median value was 1.02 (0.99–1.07) and HI, 1.07 (1.06–1.09); a great reduction was observed for CI and OAR mean doses with respect to Lee et al. data; median maximum eye lens dose was 7.3 Gy (4.0–12.0); mean LungV20Gy was 1.9%; in children, vertebrae were homogeneously irradiated (D95%=20.8 Gy, Dmean= 23.2 Gy).All pre-treatment verifications were found within our action levels except for Portal Dosimetry. Conclusion: A RapidArc planning process for craniospinal axis irradiation has been implemented with significant advantages on conformity, homogeneity, feasibility and efficiency. and increase brain tissue sparing. Variations in volume decrease may be related to shape or location of the tumor.

  19. 17 CFR 229.401 - (Item 401) Directors, executive officers, promoters and control persons.

    Science.gov (United States)

    2010-04-01

    ... “family relationship” means any relationship by blood, marriage, or adoption, not more remote than first... merchant, introducing broker, commodity trading advisor, commodity pool operator, floor broker, leverage...

  20. 17 CFR 229.404 - (Item 404) Transactions with related persons, promoters and certain control persons.

    Science.gov (United States)

    2010-04-01

    ... child, stepchild, parent, stepparent, spouse, sibling, mother-in-law, father-in-law, son-in-law... person's position(s) or relationship(s) with, or ownership in, a firm, corporation, or other entity that... such security holder, which means any child, stepchild, parent, stepparent, spouse, sibling, mother-in...

  1. Yeast Interacting Proteins Database: YNL041C, YDR229W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available pholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially...teracts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes

  2. The expression of the hepatocyte SLAMF3 (CD229 receptor enhances the hepatitis C virus infection.

    Directory of Open Access Journals (Sweden)

    Flora Cartier

    Full Text Available Hepatitis C virus (HCV is a leading cause of cirrhosis and liver cancer worldwide. We recently characterized for the first time the expression of Signaling Lymphocyte Activating Molecule 3 (SLAMF3 in human hepatocytes and here, we report that SLAMF3 interacts with the HCV viral protein E2 and is implicated in HCV entry process. We found a strong correlation between SLAMF3 expression level and hepatocyte susceptibility to HCV infection. The use of specific siRNAs to down-modulate SLAMF3 expression and SLAMF3-blocking antibodies both decreased the hepatocytes susceptibility to HCV infection. Moreover, SLAMF3 over-expression significantly increased susceptibility to HCV infection. Interestingly, experiments with peptides derived from each SLAMF3 domain showed that the first N-terminal extracellular domain is essential for interaction with HCV particles. Finally, we showed that recombinant HCV envelop protein E2 can bind SLAMF3 and that anti-SLAMF3 antibodies inhibited specifically this interaction. Overall, our results revealed that SLAMF3 plays a role during HCV entry, likely by enhancing entry of viral particle within hepatocytes.

  3. The expression of the hepatocyte SLAMF3 (CD229) receptor enhances the hepatitis C virus infection.

    Science.gov (United States)

    Cartier, Flora; Marcq, Ingrid; Douam, Florian; Ossart, Christèle; Regnier, Aline; Debuysscher, Véronique; Lavillette, Dimitri; Bouhlal, Hicham

    2014-01-01

    Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. We recently characterized for the first time the expression of Signaling Lymphocyte Activating Molecule 3 (SLAMF3) in human hepatocytes and here, we report that SLAMF3 interacts with the HCV viral protein E2 and is implicated in HCV entry process. We found a strong correlation between SLAMF3 expression level and hepatocyte susceptibility to HCV infection. The use of specific siRNAs to down-modulate SLAMF3 expression and SLAMF3-blocking antibodies both decreased the hepatocytes susceptibility to HCV infection. Moreover, SLAMF3 over-expression significantly increased susceptibility to HCV infection. Interestingly, experiments with peptides derived from each SLAMF3 domain showed that the first N-terminal extracellular domain is essential for interaction with HCV particles. Finally, we showed that recombinant HCV envelop protein E2 can bind SLAMF3 and that anti-SLAMF3 antibodies inhibited specifically this interaction. Overall, our results revealed that SLAMF3 plays a role during HCV entry, likely by enhancing entry of viral particle within hepatocytes.

  4. 17 CFR 229.907 - (Item 907) Background of the roll-up transaction.

    Science.gov (United States)

    2010-04-01

    ... most recently completed fiscal year or is likely to experience any material adverse financial... partnerships; (ii) An acquisition of any of the partnerships or a material amount of any of their assets;...

  5. 49 CFR Appendix H to Part 229 - Static Noise Test Protocols-In-Cab Static

    Science.gov (United States)

    2010-10-01

    ... for the in-cab static measurements of locomotives. I. Measurement Instrumentation The instrumentation... electronic form. (1) Name(s) of persons conducting the test, and the date of the test. (2) Description...

  6. The European Union: Measuring Counterterrorism Cooperation. Strategic Forum, Number 229, November 2007

    Science.gov (United States)

    2007-11-01

    bank transactions, while they have about the same views as Americans with respect to monitoring Internet communication and phone calls.26 There are...system’ with 5,000 km of track.”33 Information systems, energy distribu- tion networks, and food supplies also are criti- cal sectors. The Internet is...Hacia una caracterización social del terrosimo yihadista en España: implicacio- nes en seguridad interior y acción exterior,” ARI 34/2006 (Madrid

  7. 17 CFR 229.1005 - (Item 1005) Past contacts, transactions, negotiations and agreements.

    Science.gov (United States)

    2010-04-01

    ... transaction or series of similar transactions with that person exceeds $60,000. (b) Significant corporate... and disclosed in a proxy statement, report or other communication sent to security holders by the... specifically to the discussion in the proxy statement, report or other communication that was sent to...

  8. 50 CFR 229.34 - Harbor Porpoise Take Reduction Plan Regulations-Mid-Atlantic.

    Science.gov (United States)

    2010-10-01

    ... Collisions at Sea, 1972), as depicted or noted on nautical charts published by NOAA (Coast Charts 1:80,000... or noted on nautical charts published by NOAA (Coast Charts 1:80,000 scale), and as described in 33... for Preventing Collisions at Sea, 1972), as depicted or noted on nautical charts published by...

  9. 50 CFR 229.32 - Atlantic large whale take reduction plan regulations.

    Science.gov (United States)

    2010-10-01

    ... Regulations for Preventing Collisions at Sea, 1972), as depicted or noted on nautical charts published by the National Oceanic and Atmospheric Administration (Coast Charts 1:80,000 scale), and as described in 33 CFR...,680 ft or 512.1 m) (as shown on NOAA charts 13200 (Georges Bank and Nantucket Shoals,...

  10. 20 CFR 229.85 - Substantial gainful activity by blind employee or child.

    Science.gov (United States)

    2010-04-01

    ... in any type of substantial gainful activity which requires skills or abilities comparable to those of... THE RAILROAD RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Miscellaneous Deductions and... substantial gainful activity that does not require skills or ability used in his or her previous work. However...

  11. 西格绍尔P229R DAK手枪

    Institute of Scientific and Technical Information of China (English)

    曹晓东(编译); 刘振伟(校)

    2006-01-01

    多年来,美国海军特种部队一直将西格绍尔P226“海军型”9毫米手枪作为随身武器。当年海豹突击队在获得西格手枪时曾有不同口径可以选择,在对最优秀的高效能手枪弹进行了动物实验后,最终确定了9mm口径。然而现今从美国作战部队反馈回来的信息却显示出美军作战人员对新型军用手枪的需求——改进弹膛使其能够适用有94年历史的.45ACP弹。此外,新型手枪应该是双动式,使用聚合物材料并具有拇指解脱保险功能。目前,众多生产商正在争相研制与之相关的原型样枪。

  12. 49 CFR 229.133 - Interim locomotive conspicuity measures-auxiliary external lights.

    Science.gov (United States)

    2010-10-01

    ... producing a steady beam of at least 200,000 candela, placed at the front of the locomotive, at least 36... (November 1964), of at least 500 candela. (ii) The flash rate of strobe lights shall be at least 40 flashes... light shall produce at least 200,000 candela, either steadily burning or alternately flashing. (v) The...

  13. 17 CFR 229.1015 - (Item 1015) Reports, opinions, appraisals and negotiations.

    Science.gov (United States)

    2010-04-01

    ... EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Mergers and Acquisitions... appraisal. State whether or not the subject company or affiliate has received any report, opinion (other... affiliates, and/or unaffiliated representative; and (ii) The subject company or its affiliates; (5) If...

  14. 17 CFR 229.1006 - (Item 1006) Purposes of the transaction and plans or proposals.

    Science.gov (United States)

    2010-04-01

    ... extraordinary transaction, such as a merger, reorganization or liquidation, involving the subject company or any... other actions that could impede the acquisition of control of the subject company. (d) Subject company... other acquisition of the subject company's securities by the filing person, any of its subsidiaries,...

  15. 12 CFR Appendix D to Part 229 - Indorsement, Reconverting Bank Identification, and Truncating Bank Identification Standards

    Science.gov (United States)

    2010-01-01

    ... asterisk outside the arrow at each end of the routing number to identify the bank as a reconverting bank... asterisk at each end of the number to identify the bank as a reconverting bank; (B) The indorsement date... nine-digit routing number (without arrows) and an asterisk at each end of the number. (iii)...

  16. 50 CFR 229.33 - Harbor Porpoise Take Reduction Plan Regulations-New England.

    Science.gov (United States)

    2010-10-01

    ... purposes of this subpart, a pinger is an acoustic deterrent device which, when immersed in water... closer. (c) Pinger training and authorization. The operator of a vessel may not fish with, set, haul back... under paragraph (b) of this section, unless the operator has satisfactorily received pinger training and...

  17. Can Higher Education Foster Economic Growth? Chicago Fed Letter. Number 229

    Science.gov (United States)

    Mattoon, Richard H.

    2006-01-01

    Not all observers agree that higher education and economic growth are obvious or necessary complements to each other. The controversy may be exacerbated because of the difficulty of measuring the exact contribution of colleges and universities to economic growth. Recognizing that a model based on local conditions and higher education's response…

  18. American Indians in South Dakota: A Profile. Update Series C229, No. 22.

    Science.gov (United States)

    Baer, Linda L.; Bennett, Mary A.

    Life is changing for the American Indians of South Dakota and the United States. Nationally, the population is young, growing, and becoming more urban. The South Dakota population exhibits these same traits, except that it remains predominantly rural. In South Dakota, American Indians combat poverty, unemployment, underemployment, and inadequate…

  19. Identification of Aminopeptidase N as a Cellular Receptor for Human Coronavirus-229E

    Science.gov (United States)

    1992-05-12

    feline enteric coronav irus feline infectious peritonitis virus hUman adult intestine hUman aminopeptidase N human aminopeptidase with 39 amino...coronavirus (TCV), rat coronavirus (RCV), cat feline infectious peritonitis virus (FIPV), and the hUman coronaviruses. These include the slow, patchy...While the cat, dog and pig serve as natural hosts for the other coronavirus group 1 viruses, feline infectious peritonitis virus (FIPV), canine

  20. 17 CFR 229.914 - (Item 914) Pro forma financial statements: selected financial data.

    Science.gov (United States)

    2010-04-01

    ... to be included in a roll-up transaction provide: Ratio of earnings to fixed charges, cash and cash... transaction. (b) Provide pro forma financial information (including oil and gas reserves and cash flow... and payments), earnings per share amounts, and ratio of earnings to fixed charges for the most...

  1. 17 CFR 229.1113 - (Item 1113) Structure of the transaction.

    Science.gov (United States)

    2010-04-01

    ... securities, and within each class, with respect to cash flows, credit enhancement or other support and any... pool assets or owing to security holders, adjust the rate of return on the asset-backed securities, or... narrative discussion of the allocation and priority structure of pool cash flows, present the flow of...

  2. 17 CFR 229.1103 - (Item 1103) Transaction summary and risk factors.

    Science.gov (United States)

    2010-04-01

    ... EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities... additional series or classes of securities may be issued that are backed by the same asset pool and briefly... and any class or series of the asset-backed securities represented by the prefunding account or the...

  3. 17 CFR 229.1118 - (Item 1118) Reports and additional information.

    Science.gov (United States)

    2010-04-01

    ... 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation... or entities under which reports about the asset-backed securities will be filed with the Securities... holders or information about the asset-backed securities will be made available in this manner. (3) If...

  4. 17 CFR 229.1122 - (Item 1122) Compliance with applicable servicing criteria.

    Science.gov (United States)

    2010-04-01

    ... EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities... assessment of compliance with servicing criteria for asset-backed securities. As required by paragraph (b) of... are prepared on a monthly basis for all asset-backed securities related bank accounts, including...

  5. 17 CFR 229.1121 - (Item 1121) Distribution and pool performance information.

    Science.gov (United States)

    2010-04-01

    ..., SECURITIES EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed... on the asset-backed securities by type and by class or series and any principal or interest... cash flow. (4) Beginning and ending principal balances of the asset-backed securities. (5) Interest...

  6. 17 CFR 229.1112 - (Item 1112) Significant obligors of pool assets.

    Science.gov (United States)

    2010-04-01

    ... EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities... significant obligor are asset-backed securities, provide the following information in lieu of the information... Items 1104 through 1115, 1117 and 1119 of this Regulation AB regarding such asset-backed securities; and...

  7. 17 CFR 229.912 - (Item 912) Source and amount of funds and transactional expenses.

    Science.gov (United States)

    2010-04-01

    ... roll-up transaction is a loan made in the ordinary course of business by a bank as defined by section 3... with the roll-up transaction including, but not limited to, filing fees, legal, financial advisory, accounting and appraisal fees, solicitation expenses and printing costs. Identify the persons responsible for...

  8. 49 CFR 1544.229 - Fingerprint-based criminal history records checks (CHRC): Unescorted access authority, authority...

    Science.gov (United States)

    2010-10-01

    ... within a security identification display area (SIDA), as described in § 1542.205 of this chapter... within a security identification display area (SIDA), as described in § 1542.205 of this chapter. (iii..., 2002, report the conviction to the aircraft operator and surrender the SIDA access medium to the issuer...

  9. 17 CFR 229.503 - (Item 503) Prospectus summary, risk factors, and ratio of earnings to fixed charges.

    Science.gov (United States)

    2010-04-01

    ... immediately follow the cover page of the prospectus or the pricing information section that immediately follows the cover page. Pricing information means price and price-related information that you may omit..., commonly referred to as the pro forma ratio. Instructions to paragraph 503(d): 1. Definitions....

  10. Ly9 (CD229) Cell-Surface Receptor is Crucial for the Development of Spontaneous Autoantibody Production to Nuclear Antigens.

    Science.gov (United States)

    de Salort, Jose; Cuenca, Marta; Terhorst, Cox; Engel, Pablo; Romero, Xavier

    2013-01-01

    The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demonstrate that the SLAMF member Ly9 arises as a novel receptor contributing to the reinforcement of tolerance. Specifically, Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies, independently of genetic background [(B6.129) or (BALB/c.129)]. In aged (10- to 12-month-old) Ly9 (-/-) mice key cell subsets implicated in autoimmunity were expanded, e.g., T follicular helper (Tfh) as well as germinal center (GC) B cells. More importantly, in vitro functional experiments showed that Ly9 acts as an inhibitory receptor of IFN-γ producing CD4(+) T cells. Taken together, our findings reveal that the Ly9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses.

  11. Ly9 (CD229 cell surface receptor is crucial for the development of spontaneous autoantibody production to nuclear antigens

    Directory of Open Access Journals (Sweden)

    Jose ede Salort

    2013-07-01

    Full Text Available The Signaling Lymphocyte Activation Molecule Family (SLAMF genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE. Herein, we demonstrate that the SLAMF member Ly9 arises as a novel receptor contributing to the reinforcement of tolerance. Specifically, Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-ANA, -dsDNA and -nucleosome autoantibodies, independently of genetic background ([B6.129] or [BALB/c.129]. In aged [10-12 month old] Ly9-/- mice key cell subsets implicated in autoimmunity were expanded, e.g. T follicular helper (Tfh as well as germinal center (GC B cells. More importantly, in vitro functional experiments showed that Ly9 acts as an inhibitory receptor of IFN-g producing CD4+T cells. Taken together, our findings reveal that the Ly9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses.

  12. Identification of a laccase from Ganoderma lucidum CBS 229.93 having potential for enhancing cellulase catalyzed lignocellulose degradation

    DEFF Research Database (Denmark)

    Sitarz, Anna Katarzyna; Mikkelsen, Jørn Dalgaard; Højrup, Peter

    2013-01-01

    . Addition of the laccase-rich G. lucidum broth to lignocellulosic biomass (pretreated sugar cane bagasse) together with a state-of-the-art cellulase enzyme preparation (Cellic™CTec1) produced significantly increased cellulolytic yields, which were also better than those obtained with a T. versicolor laccase...... extract or minimal media supplemented with alkali lignin. When grown on malt extract or minimal medium supplemented with lignocellulose (sugar cane bagasse), the crude G. lucidum protein extract exhibited high laccase activity, ∼3U/mL toward syringaldazine. This activity was 13–17 fold higher than...... addition, indicating that the laccase from G. lucidum has unique properties that may be momentous in lignocellulosic biomass conversion....

  13. P2-29: Comparing the Other-Race-Effect and Congenital Prosopagnosia Using a Three-Experiment Test Battery

    Directory of Open Access Journals (Sweden)

    Janina Esins

    2012-10-01

    Full Text Available Congenital prosopagnosia, an innate impairment in recognizing faces, as well as the other-race-effect, the disadvantage in recognizing faces of foreign races, both influence face recognition abilities. Here we compared both phenomena by testing three groups: German congenital prosopagnosics (cPs, unimpaired German, and unimpaired South Korean participants (n = 23 per group, on three tests with Caucasian faces. First we ran the Cambridge Face Memory Test (Duchaine & Nakayama, 2006 Neuropsychologia 44 576–585. Participants had to recognize Caucasian target faces in a 3AFC task. German controls performed better than Koreans (p = .009 who performed better than prosopagnosics (p = .0001. Variation of the individual performances was larger for cPs than for Koreans (p = .028. In the second experiment, participants rated the similarity of Caucasian faces (in-house 3D face-database which differed parametrically in features or second order relations (configuration. We found differences between sensitivities to change type (featural or configural, p = 0 and between groups (p = .005 and an interaction between both factors (p = .019. During the third experiment, participants had to learn exemplars of artificial objects (greebles, natural objects (shells, and faces and recognize them among distractors. The results showed an interaction (p = .005 between stimulus type and participant group: cPs where better for non-face stimuli and worse for face stimuli than the other groups. Our results suggest that congenital prosopagnosia and the other-race-effect affect face perception in different ways. The broad range in performance for the cPs directs the focus of our future research towards looking for different forms of congenital prosopagnosia.

  14. 17 CFR 229.201 - (Item 201) Market price of and dividends on the registrant's common equity and related...

    Science.gov (United States)

    2010-04-01

    ...) That is subject to outstanding options or warrants to purchase, or securities convertible into, common... the question of their intention to pay cash dividends in the foreseeable future and, if no such intention exists, to make a statement of that fact in the filing. Registrants which have a history of...

  15. Identification of a laccase from Ganoderma lucidum CBS 229.93 having potential for enhancing cellulase catalyzed lignocellulose degradation.

    Science.gov (United States)

    Sitarz, Anna K; Mikkelsen, Jørn D; Højrup, Peter; Meyer, Anne S

    2013-12-10

    Based on a differential pre-screening of 44 white-rot fungi on a lignocellulose-supplemented minimal medium, four basidiomycetes were selected for further study: Ganoderma lucidum, Polyporus brumalis, Polyporus ciliatus and Trametes versicolor. Only G. lucidum was able to grow vividly on malt extract or minimal media supplemented with alkali lignin. When grown on malt extract or minimal medium supplemented with lignocellulose (sugar cane bagasse), the crude G. lucidum protein extract exhibited high laccase activity, ∼3U/mL toward syringaldazine. This activity was 13-17 fold higher than the corresponding activities of the crude protein extracts of P. brumalis, P. ciliatus and T. versicolor. Native PAGE electrophoresis of the crude G. lucidum extract confirmed the presence of an active laccase. The G. lucidum laccase had a molecular weight of ∼62.5kDa, and a Km value of 0.107mM (determined on ABTS). A partial amino acid sequence analysis of four short de novo sequenced peptides, defined after trypsin digest analysis using MALDI-TOF MS/MS analysis, revealed 64-100% homology to sequences in related laccases in the UniProt database, but also indicated that certain sequence stretches had low homology. Addition of the laccase-rich G. lucidum broth to lignocellulosic biomass (pretreated sugar cane bagasse) together with a state-of-the-art cellulase enzyme preparation (Cellic™CTec1) produced significantly increased cellulolytic yields, which were also better than those obtained with a T. versicolor laccase addition, indicating that the laccase from G. lucidum has unique properties that may be momentous in lignocellulosic biomass conversion.

  16. 32 CFR 229.14 - Determination of archaeological or commercial value and cost of restoration and repair.

    Science.gov (United States)

    2010-07-01

    ... limited to, the cost of preparing a research design, conducting field work, carrying out laboratory analysis, and preparing reports as would be necessary to realize the information potential. (b) Commercial... shall be its fair market value. Where the violation has resulted in damage to the...

  17. 78 FR 35567 - Safety Zone; Lower Mississippi River, Mile Marker 219 to Mile Marker 229, in the Vicinity of Port...

    Science.gov (United States)

    2013-06-13

    ...: If you have questions on this rule, call or email Lieutenant Christopher Norton, Coast Guard Marine Safety Unit Baton Rouge; telephone (225) 298-5400, email Christopher.R.Norton@uscg.mil . If you have... Norton, Marine Safety Unit Baton Rouge, at (225) 298-5400 or Christopher.R.Norton@uscg.mil ....

  18. Japan's emergence as a global power; James I. Matray : Greenwood Press. Westport, Connecticut-London. 2001. 229 pp.

    OpenAIRE

    2002-01-01

    La derrota en la Segunda Guerra Mundial cambió la historia previa del Japón, que dedicó su atención al crecimiento económico. De esta manera se transformó en una de las más prósperas y productivas naciones en la historia de la humanidad. James Matray ofrece en este libro una prolija secuencia de los sucesos que afectaron a Japón desde 1945 hasta 2000, además de biografías de los principales actores involucrados y un anexo con los principales documentos que contribuyeron a edificicar el Japón ...

  19. Band structure and decay channels of thorium-229 low-lying isomeric state for ensemble of thorium atoms adsorbed on calcium fluoride

    OpenAIRE

    Borisyuk, P. V.; Vasilyev, O S; Krasavin, A.V.; Lebedinskii, Yu Yu; V. I. Troyan; Tkalya, E. V.

    2015-01-01

    The results are presented on the study of the electronic structure of thorium atoms adsorbed by the liquid atomic layer deposition from aqueous solution of thorium nitrate on the surface of CaF2. The chemical state of the atoms and the change of the band structure in the surface layers of Th/CaF2 system on CaF2 substrate were investigated by XPS and REELS techniques. It was found that REELS spectra for Th/CaF2 system include peaks in the region of low energy losses (3-7 eV) which are missing ...

  20. College and Career Readiness Profiles of High School Graduates in American Samoa and the Commonwealth of the Northern Mariana Islands. REL 2017-229

    Science.gov (United States)

    Herman, Phillip; Carreon, Daisy; Scanlan, Spencer; Dandapani, Nitara

    2017-01-01

    Many jurisdictions use data about college and career readiness to help stakeholders understand whether students are on track to succeed in college and careers after high school graduation. For example, Hawaii includes the percentage of high school graduates from a particular school who later attend college in school-level feedback reports for…

  1. 20 CFR 229.42 - When a child can no longer be included in computing an annuity rate under the overall minimum.

    Science.gov (United States)

    2010-04-01

    ... secondary school, and not disabled; or (f) The month before the month the child becomes entitled to an... annuity rate under the overall minimum. A child's inclusion in the computation of the overall minimum rate... second month after the month the child's disability ends, if the child is 18 years old or older, and...

  2. Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells.

    Science.gov (United States)

    Sintes, Jordi; Cuenca, Marta; Romero, Xavier; Bastos, Ricardo; Terhorst, Cox; Angulo, Ana; Engel, Pablo

    2013-01-01

    Signaling lymphocytic activation molecule family receptors and the specific adapter signaling lymphocytic activation molecule-associated protein modulate the development of innate-like lymphocytes. In this study, we show that the thymus of Ly9-deficient mice contains an expanded population of CD8 single-positive cells with the characteristic phenotype of innate memory-like CD8(+) T cells. Moreover, the proportion of these innate CD8(+) T cells increased dramatically postinfection with mouse CMV. Gene expression profiling of Ly9-deficient mice thymi showed a significant upregulation of IL-4 and promyelocytic leukemia zinc finger. Analyses of Ly9(-/-)IL4ra(-/-) double-deficient mice revealed that IL-4 was needed to generate the thymic innate CD8(+) T cell subset. Furthermore, increased numbers of invariant NKT cells were detected in Ly9-deficient thymi. In wild-type mice, IL-4 levels induced by α-galactosylceramide injection could be inhibited by a mAb against Ly9. Thus, Ly9 plays a unique role as an inhibitory cell surface receptor regulating the size of the thymic innate CD8(+) T cell pool and the development of invariant NKT cells.

  3. Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and iNKT cells

    Science.gov (United States)

    Sintes, Jordi; Cuenca, Marta; Romero, Xavier; Bastos, Ricardo; Terhorst, Cox; Angulo, Ana; Engel, Pablo

    2012-01-01

    Signaling lymphocytic activation molecule family (SLAMF) receptors and the specific adapter SLAM-associated protein (SAP) modulate the development of innate-like lymphocytes. Here, we show that the thymus of Ly9-deficient mice contains an expanded population of CD8 single-positive cells with the characteristic phenotype of innate memory-like CD8+ T-cells. Moreover, the proportion of these innate CD8+ T-cells increased dramatically after infection with mouse cytomegalovirus. Gene expression profiling of Ly9-deficient mice thymi showed a significant up-regulation of IL-4 and PLZF. Analyses of Ly9−/−IL4ra−/− double-deficient mice revealed that IL-4 was needed to generate the thymic innate CD8+ T-cell subset. Furthermore, increased numbers of iNKT cells were detected in Ly9-deficient thymi. In wild-type mice IL-4 levels induced by αGalCer injection could be inhibited by a monoclonal antibody against Ly9. Thus, Ly9 plays a unique role as an inhibitory cell-surface receptor regulating the size of the thymic innate CD8+ T-cell pool and the development of iNKT cells. PMID:23225888

  4. Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty

    DEFF Research Database (Denmark)

    Mogensen, Signe Sloth; Aksglaede, Lise; Mouritsen, Annette

    2012-01-01

    Central precocious puberty may result from organic brain lesions, but is most frequently of idiopathic origin. Clinical or biochemical factors which could predict a pathological brain MRI in girls with CPP have been searched for. With the recent decline in age at pubertal onset among US and Europ......Central precocious puberty may result from organic brain lesions, but is most frequently of idiopathic origin. Clinical or biochemical factors which could predict a pathological brain MRI in girls with CPP have been searched for. With the recent decline in age at pubertal onset among US...

  5. I. The metabolic properties of plutonium and allied materials

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  6. Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.

    Science.gov (United States)

    Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R; Wai, Chien M

    1999-09-01

    A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

  7. New production in the South China Sea

    Institute of Scientific and Technical Information of China (English)

    CAI; Pinghe

    2002-01-01

    [1]Dugdale, R. C., Goering, J. J., Uptake of new and regenerated nitrogen in primary productivity, Limnology and Oceanog-raphy, 1967, 12: 196-206.[2]Eppley, R. W., Peterson, B. J., Particulate organic matter flux and planktonic new production in the deep ocean, Nature, 1979, 282: 677-680.[3]Allen, C. B., Kanda, J., Laws, E. A., New production and photosynthetic rates within and outside a cyclonic mesoscale eddy in the North Pacific Subtropical gyre, Deep-Sea Research Ⅱ, 1996, 43(6): 917-936.[4]Jenkins, W. J., Tritium-helium dating in the Sargasso Sea: A measurement of oxygen utilization rates, Nature, 1977, 196: 291-292.[5]Spitzer, W. S., Jenkins, W. J., Rates of vertical mixing, gas exchange and new production: Estimates from seasonal gas cy-cle in the upper ocean near Bermuda, Journal of Marine Research, 1989, 47: 169-196.[6]Sarmiento, J. L., Thiele, G., Key, R. M. et al., Oxygen and nitrate new production and remineralization in the North At-lantic Subtropical Gyre, Journal of Geophysical Research, 1990, 95: 18303-18315.[7]Ku, T. L., Luo, S., Kusakabe, M. et al., 228Ra-derived nutrient budgets in upper equatorial Pacific and the role of "new" silicate in limiting productivity, Deep-Sea Research II, 1995, 42(2/3): 479-497.[8]Wheeler, P. A., Rates of nitrate assimilation at the equator during the US-JGOFS spring time series: Estimates of new pro-duction, EOS, Transactions, American Geophysical Union, 1992, 73: 281.[9]Huang, Y., Xie, Y., Chen, M. et al., Distribution feature of 228Ra in surface seawater of the Nansha sea area, in Isotopes Marine Chemistry of Nansha Islands Waters (in Chinese), Beijing: Ocean Press, 1996, 70-78.[10]Reid, D. F., Key, R. M., Schink, D., Radium, thorium and actinium extraction from seawater using an improved manga-nese-oxide-coated fiber, Earth and Planetary Science Letters, 1979, 43: 223-226.[11]Shi, W., Qiu, X., Huang, Y., Distribution of dissolved 226Ra in the Jiulongjiang-Xiamen bay

  8. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  9. A clínica terapêutica ocupacional com usuários de substâncias psicoativas: o desafio da práxis - doi:10.5020/18061230.2006.p229

    Directory of Open Access Journals (Sweden)

    Yvana Coutinho de Oliveira

    2012-01-01

    Full Text Available A Política do Ministério da Saúde para a Atenção Integral a Usuários de Álcool e outras Drogas tem priorizado ações de caráter terapêutico, reabilitativo e de humanização em suas diversas unidades assistenciais. Neste contexto, a Terapia Ocupacional tem um campo fértil de atuação no conjunto de atividades que estão relacionadas à reabilitação psicossocial de indivíduos drogadictos. Neste trabalho, a autora relata, então, a sua experiência clínica terapêutica ocupacional com usuários de substâncias psicoativas em uma instituição psiquiátrica hospitalar, fazendo uma revisão teórica sobre o tema e tecendo considerações metodológicas sobre a práxis terapêutica. A metodologia utilizada foi a do tipo descritiva, na qual a observação no espaço institucional e os atendimentos em grupo foram os principais instrumentos utilizados. Como resultados, a autora refere o enorme prejuízo causado pela dependência química nos usuários, em suas famílias e na sociedade de uma forma geral. A atuação terapêutica ocupacional, principalmente utilizando abordagens grupais, mostra-se bastante eficaz no processo terapêutico, por facilitar expressão de subjetividades e auxiliar a reconstrução psíquica destes indivíduos. No entanto, torna-se urgente a implantação de mais espaços terapêuticos especializados no tratamento de drogadictos, bem como medidas eficientes de prevenção e controle da problemática do narcotráfico.

  10. UPDATE ON US NATIONAL PRRS PROJECT PLANS: THE USDA FUNDED PRRS CAP PROGRAM, THE NPB FUNDED PRRS HOST GENETIC CONSORTIUM, AND US NATIONAL SWINE RESPIRATORY DISEASE NC229 PROJECT

    Science.gov (United States)

    There are several major US efforts to address swine respiratory diseases. These include the US Department of Agriculture (USDA) funded PRRS coordinated agricultural project (PRRS CAP), the US National Pork Board (NPB) funded PRRS Host Genetic Consortium (PHGC), and the US national Swine Respiratory ...

  11. Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif.

    Science.gov (United States)

    Vedula, L Sangeetha; Jiang, Jiaoyang; Zakharian, Tatiana; Cane, David E; Christianson, David W

    2008-01-15

    Trichodiene synthase from Fusarium sporotrichioides contains two metal ion-binding motifs required for the cyclization of farnesyl diphosphate: the "aspartate-rich" motif D(100)DXX(D/E) that coordinates to Mg2+A and Mg2+C, and the "NSE/DTE" motif N(225)DXXSXXXE that chelates Mg2+B (boldface indicates metal ion ligands). Here, we report steady-state kinetic parameters, product array analyses, and X-ray crystal structures of trichodiene synthase mutants in which the fungal NSE motif is progressively converted into a plant-like DDXXTXXXE motif, resulting in a degradation in both steady-state kinetic parameters and product specificity. Each catalytically active mutant generates a different distribution of sesquiterpene products, and three newly detected sesquiterpenes are identified. In addition, the kinetic and structural properties of the Y295F mutant of trichodiene synthase were found to be similar to those of the wild-type enzyme, thereby ruling out a proposed role for Y295 in catalysis.

  12. Methyl 5,7-dihydroxy-2,2,9-trimethyl-6,11-dioxo-6,11-dihydro-2H-anthra[2,3-b]pyran-8-carboxylate

    Directory of Open Access Journals (Sweden)

    Annelise Lobstein

    2008-12-01

    Full Text Available The title compound, C22H18O7, also known as laurentiquinone B, is a new anthraquinone which was isolated from Vismia laurentii, a Cameroonian medicinal plant. The asymmetric unit contains two independent molecules. Each of them contains four fused rings, three of which are coplanar and typical of anthracene, while the heterocyclic rings adopt envelope conformations. Intramolecular O—H...O hydrogen bonds result in the formation of two planar rings, which are also almost coplanar with the adjacent rings. In the crystal structure, intermolecular O—H...O and C—H...O hydrogen bonds link the molecules and a π–π contact is also present [centroid-centroid distance = 3.967 (3 Å].

  13. Behaviour of uranium series radionuclides in surface water (Crouzille, Limousin). Geochemical implications; Comportement des radionucleides des familles de l'uranium dans les eaux superficielles du site de la Crouzille (Limousin): implications geochimiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-06-15

    Understanding natural radionuclides behaviour in surface water is a required step to achieve uranium mine rehabilitation and preserve water quality. The first objective of this thesis is to determine which are the radionuclides sources in a drinking water reservoir. The second objective is to improve the knowledge about the behaviour of uranium series radionuclides, especially actinium. The investigated site is a brook (Sagnes, Limousin, France) which floods a peat bog contaminated by a former uranium mine and which empties into the Crouzille lake. It allows studying radionuclides transport in surface water and radionuclides retention through organic substance or water reservoir. Radionuclides distribution in particulate, colloidal and dissolved phases is determined thanks to ultra-filtrations. Gamma spectrometry allows measuring almost all natural radionuclides with only two counting stages. However, low activities of {sup 235}U series radionuclides impose the use of very low background well-type Ge detectors, such as those of the Underground Laboratory of Modane (France). Firstly, this study shows that no or few radionuclides are released by the Sagnes peat bog, although its radioactivity is important. Secondly, it provides details on the behaviour of uranium series radionuclides in surface water. More specifically, it provides the first indications of actinium solubility in surface water. Actinium's behaviour is very close to uranium's even if it is a little less soluble. (author)

  14. 76 FR 73911 - List of Fisheries for 2012

    Science.gov (United States)

    2011-11-29

    ... 229 List of Fisheries for 2012; Final Rule #0;#0;Federal Register / Vol. 76, No. 229 / Tuesday... Administration 50 CFR Part 229 RIN 0648-BA76 List of Fisheries for 2012 AGENCY: National Marine Fisheries Service...: The National Marine Fisheries Service (NMFS) publishes its final List of Fisheries (LOF) for 2012,...

  15. Experiment list: SRX367451 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available e Diagnosis=Glioma 24276847,81.9,0.6,269 GSM1250287: LN229-SOX4; Homo sapiens; ChIP-Seq source_name=LN229 human glioblastoma... cell line with SOX4 overexpression || cell line=LN229 glioblastoma cell line || genotype/va

  16. Experiment list: SRX367452 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available e Diagnosis=Glioma 15549382,80.1,4.2,242 GSM1250288: LN229-control; Homo sapiens; ChIP-Seq source_name=LN229 human glioblastoma... cell line with GFP overexpression || cell line=LN229 glioblastoma cell line || genotype/

  17. CRYSTALLOGRAPHIC STUDIES OF THE INTERACTION OF CYCLODEXTRIN GLYCOSYLTRANSFERASE FROM BACILLUS-CIRCULANS STRAIN-251 WITH NATURAL SUBSTRATES AND PRODUCTS

    NARCIS (Netherlands)

    KNEGTEL, RMK; STROKOPYTOV, B; PENNINGA, D; FABER, OG; ROZEBOOM, HJ; KALK, KH; DIJKHUIZEN, L; DIJKSTRA, BW

    1995-01-01

    Asp-229, Glu-257, and Asp-328 constitute the catalytic residues in cyclodextrin glycosyl transferase from Bacillus circulans strain 251. Via site-directed mutagenesis constructed D229N, E257Q, and D328N mutant proteins showed a 4,000-60,000 fold reduction of cyclization activity. A D229N/E257Q

  18. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    P. Bernot

    2005-07-13

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with {sup 231}Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or

  19. Transition wavelengths and unresolved transition array statistics of ions with Z = 72-89

    Energy Technology Data Exchange (ETDEWEB)

    Kilbane, D, E-mail: Deirdre.Kilbane@ucd.ie [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland)

    2011-08-28

    Potential extreme ultraviolet and soft x-ray radiation sources have been identified, using the flexible atomic code (FAC), as emission peaks arising from the 4d-4f and 4p-4d transitions in Pd-like to Rb-like ions of hafnium through actinium. The effects of configuration interaction are investigated and for increasing nuclear charge, these strong emitters are seen to separate and move to shorter wavelengths. Each source is characterized using the unresolved transition array model. They are proposed to complement the currently used nitrogen and argon sources in the 'water window', and as possible successors to tin in next-generation lithography.

  20. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  1. Analysis of the Yrast Bands with q-Deformed Moment of Inertia

    Institute of Scientific and Technical Information of China (English)

    FANG Xiang-Zheng; RUAN Tu-Nan

    2001-01-01

    The rigid-rotor with a q-deformed moment of inertia is introduced to describe the nuclear rotational spectra. With the representations of quantum algebra, the normal deformed and superdeformed bands are naturally differentiated by softness. The yrast normal deformed bands in rare earth and actinium regions, as well as the yrast superdeformed bands in A-190 and 150 regions are investigated. The calculated results agree with experimental data qualitatively well, and the values of the parameters are physically reasonable. This indicates that the fixed deformation, the stretching effect and the many body statistics effect are three possible dominant factors to govern nuclear rotational bands.

  2. Purification of cerium, neodymium and gadolinium for low background experiments

    Directory of Open Access Journals (Sweden)

    Boiko R.S.

    2014-01-01

    Full Text Available Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search, 136Ce (2β+ candidate with one of the highest Q2β. The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  3. Large scale accelerator production of (225)Ac: Effective cross sections for 78-192MeV protons incident on (232)Th targets.

    Science.gov (United States)

    Griswold, J R; Medvedev, D G; Engle, J W; Copping, R; Fitzsimmons, J M; Radchenko, V; Cooley, J C; Fassbender, M E; Denton, D L; Murphy, K E; Owens, A C; Birnbaum, E R; John, K D; Nortier, F M; Stracener, D W; Heilbronn, L H; Mausner, L F; Mirzadeh, S

    2016-12-01

    Actinium-225 and (213)Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of (225)Ac. The high-energy proton spallation reaction on natural thorium metal targets has been utilized to produce millicurie quantities of (225)Ac. The results of sixteen irradiation experiments of thorium metal at beam energies between 78 and 192MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL). Excitation functions for actinium and thorium isotopes, as well as for some of the fission products, are presented. The cross sections for production of (225)Ac range from 3.6 to 16.7mb in the incident proton energy range of 78-192MeV. Based on these data, production of curie quantities of (225)Ac is possible by irradiating a 5.0gcm(-2 232)Th target for 10 days in either BNL or LANL proton irradiation facilities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Directory of Open Access Journals (Sweden)

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  5. S. 406: Amendment No. 229 to authorize competitive oil and gas leasing and development on the Coastal Plain of the Arctic National Wildlife Refuge in a manner consistent with protection of the environment, and for other purposes. Introduced in the Senate of the United States, One Hundred First Congress, First Session, June 23, 1989

    Energy Technology Data Exchange (ETDEWEB)

    1989-01-01

    This amendment to the Outer Continental Shelf Lands Act would authorize competitive oil and gas leasing and development on the Arctic National Wildlife Refuge in a manner consistent with protection of the environment. The amendment include the Gulf of Mexico and lower Mississippi River into the Lands Act. The offshore oil pollution compensation fund, containing an oil pollution account and a wetlands protection, restoration, and enhancement account, is increased. The inspection of oil spill prevention and containment equipment for the outer continental shelf; oil spill contingency planning; vessel design and spill prevention; impact on state law or on liability under other law; penalties; and cooperative development of common hydrocarbon-bearing areas are addressed in separate sections of this amendment.

  6. Comment on F.J.Ernst, V.S.Manko and E.Ruiz "On interrelations between Sibgatullin's and Alekseev's approaches to the construction of exact solutions of the Einstein-Maxwell equations" (J.Phys.:Conf.Ser.229(2010)012050; arXiv:1006.5118)

    CERN Document Server

    Alekseev, G A

    2010-01-01

    The necessity of this Comment was invoked by numerous mistakes, erroneous discussions and misleading citations curiously collected in the paper of F.J.Ernst, V.S.Manko and E.Ruiz and concerning the interrelations between two integral equation methods developed for solution of Einstein - Maxwell equations more than twenty five years ago. At first, we clarify the origin of the errors in the paper of F.J.Ernst, V.S.Manko and E.Ruiz which gave rise to so curious authors "conclusions" as that the monodromy transform integral equations "...are simple combinations of Sibgatullin's integral equations and normalizing conditions..." or even that "...in the electrovac case Alekseev's integral equations are erroneous...". In the Comment, the way of correct derivation of Sibgatullin's reduction of the Hauser and Ernst integral equations in the context of the monodromy transform approach is briefly outlined. In response to various speculations and priority claims collected in the section 3 of the F.J.Ernst, V.S.Manko and E...

  7. Protein (Cyanobacteria): 209852 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available ZP_07970191.1 1117:3992 1118:3229 1129:675 232363:229 molybdopterin biosynthesis pr...EPPPPGMVPSCAEGGVVGVLPGIIGVIQATEAVKIITGIGTTLSGRLLLFDALGMKFRELKLRPNPERPVIDKLIDYQEFCGVGGTAPGQEEAGSVESIS

  8. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  9. Temporal Variations in Surface Concentrations of Terrestrial Lead 210 and Uranium 235 Radionucleides

    Science.gov (United States)

    Yoshimori, M.

    We have started to measure the surface concentrations of terrestrial radionucleides of lead 210 and uranium 235 in Tokyo (N35, E139) in 2002. Lead 210 which is a daughter nucleus of Rn-222 (uranium series) emits 46 keV gamma-ray with a half-life of 22.4 years, while uranium 235 (actinium series) emits a gamma-ray at 186 keV with a half-life of 0.7 billion years. The present measurement of the surface concentration of lead 210 exhibits two peaks in spring and fall, similar to the beryllium 7 seasonal variations, while the uranium 235 concentration does not vary with time within statistical errors. These two terrestrial radionucleides exhibit different temporal variations on the surface. We discuss possible explanations for the differences in the temporal variations from a point of view of differences in their altitude distribution.

  10. Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion

    Science.gov (United States)

    Ferrer, R.; Barzakh, A.; Bastin, B.; Beerwerth, R.; Block, M.; Creemers, P.; Grawe, H.; de Groote, R.; Delahaye, P.; Fléchard, X.; Franchoo, S.; Fritzsche, S.; Gaffney, L. P.; Ghys, L.; Gins, W.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Loiselet, M.; Lutton, F.; Moore, I. D.; Martínez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Raeder, S.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Thomas, J-C; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2017-01-01

    Resonant laser ionization and spectroscopy are widely used techniques at radioactive ion beam facilities to produce pure beams of exotic nuclei and measure the shape, size, spin and electromagnetic multipole moments of these nuclei. However, in such measurements it is difficult to combine a high efficiency with a high spectral resolution. Here we demonstrate the on-line application of atomic laser ionization spectroscopy in a supersonic gas jet, a technique suited for high-precision studies of the ground- and isomeric-state properties of nuclei located at the extremes of stability. The technique is characterized in a measurement on actinium isotopes around the N=126 neutron shell closure. A significant improvement in the spectral resolution by more than one order of magnitude is achieved in these experiments without loss in efficiency. PMID:28224987

  11. Gclust Server: 196842 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 196842 Caur_c101_g229 Cluster Sequences - 99 no annotation 1 1.00e-50 0.0 0.0 0.0 6.67 0.0 0.0 Show 1968...42 Cluster ID 196842 Sequence ID Caur_c101_g229 Link to cluster sequences Cluster Seque

  12. 77 FR 19128 - Defense Federal Acquisition Regulation Supplement: Separation of Combined Provisions and Clauses...

    Science.gov (United States)

    2012-03-30

    ... grammatical changes to paragraph (a) of 252.229-7005, Tax Exemptions (Spain). III. Executive Orders 12866 and... proposed rule in the Federal Register at 76 FR 71922 on November 21, 2011, to separate provisions and... (Spain)... 252.229-7013, Tax Exemptions (Spain)--Representation. Conforming changes are also required...

  13. 17 CFR 240.14a-3 - Information to be furnished to security holders.

    Science.gov (United States)

    2010-04-01

    ... Schedule 14A (§ 240.14a-101), if: (i) The solicitation relates to a business combination transaction as... selected financial data required by Item 301 of Regulation S-K (§ 229.301 of this chapter). (ii) The report... quantitative and qualitative disclosures about market risk required by Item 305 of Regulation S-K (§ 229.305 of...

  14. EST Table: AV404441 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AV404441 pg--0982 10/09/28 79 %/229 aa ref|XP_001998398.1| GI23651 [Drosophila mojav...ensis] gb|EDW13859.1| GI23651 [Drosophila mojavensis] 10/08/28 79 %/229 aa FBpp0172868|DmojGI23651-PA 10/08

  15. 36 CFR 79.10 - Use of collections.

    Science.gov (United States)

    2010-07-01

    ... where the resource is located. (2) Section -.18(a)(2) of uniform regulations 43 CFR part 7, 36 CFR part 296, 18 CFR part 1312, and 32 CFR part 229 sets forth procedures whereby information relating to the... CFR part 7, 36 CFR part 296, 18 CFR part 1312, and 32 CFR part 229 on: (i) Scientific, educational...

  16. 12 CFR 210.12 - Return of cash items and handling of returned checks.

    Science.gov (United States)

    2010-01-01

    ... information portion of the item contains a record of all MICR-line information required for a substitute check... the item contains a record of all MICR-line information required for a substitute check under § 229.2... the item contains a record of all MICR-line information required for a substitute check under § 229.2...

  17. Socio-economic status of Dog owners in Nagpur city of Maharashtra

    Directory of Open Access Journals (Sweden)

    A.D. Sawaimul

    2009-12-01

    Full Text Available The survey was carried out to study socioeconomic status of 50 dog owners in Nagpur of Maharashtra.The result revealed the businessmen (38% are more interested in dog keeping followed by government servants (16% and student (12%. [Vet World 2009; 2(6.000: 229-229

  18. The Business of Politics Commerce, and Culture in East Asia

    DEFF Research Database (Denmark)

    Ooi, Can-Seng

    2016-01-01

    Review of: "Cultural Policies in East Asia: Dynamics Between the State, Arts and Creative Industries". Edited by Hye-Kyung Lee and Lorraine Lim. Basingstoke: Palgrave, Macmillan, 2014. 229 pp.......Review of: "Cultural Policies in East Asia: Dynamics Between the State, Arts and Creative Industries". Edited by Hye-Kyung Lee and Lorraine Lim. Basingstoke: Palgrave, Macmillan, 2014. 229 pp....

  19. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... One Couple's Story of Living While Dying - Duration: 2:20. HPCancer 7,795 views 2:20 Grief and nurses working in pediatric palliative ... 898 views 6:37 Pediatric Palliative Care - Duration: 2:29. NINRnews 4,704 views 2:29 Teen ...

  20. 75 FR 38172 - Petition for Waiver of Compliance

    Science.gov (United States)

    2010-07-01

    ....413, 238.417, 238.419); 49 CFR part 231, Railroad Safety Appliance Standards (Sec. 231.14); and 49 CFR part 229, Railroad Locomotive Safety Standards (Sec. 229.141). DXE intends to design, develop, and... these train-sets to climb steep grades. No push-pull or locomotive-hauled trains will be used, so...

  1. 78 FR 14874 - Petition for Waiver of Compliance

    Science.gov (United States)

    2013-03-07

    ... safety regulations contained at 49 CFR parts 229--Railroad Locomotive Safety Standards; 236--Rules... Train Control Systems, Devices and Appliances; and 238--Passenger Equipment Safety Standards due to...--Movement of ] non-complying locomotives, 49 CFR 229.23-Periodic inspection: general, 49 CFR...

  2. 77 FR 19411 - Petition for Waiver of Compliance

    Science.gov (United States)

    2012-03-30

    ... safety regulations ] contained at 49 CFR Section 229.23 (which requires a periodic inspection every 92 days) and 49 CFR Section 229.25 (which requires specific tests to be done at every periodic inspection... review online at www.regulations.gov and in person at the U.S. Department of Transportation's...

  3. 76 FR 16861 - Availability of Funds and Collection of Checks

    Science.gov (United States)

    2011-03-25

    ... proposed rule. \\29\\ See Regulation CC Sec. 229.20 and EFA Act Sec. 608. A state's funds-availability law...: Background Regulation CC (12 CFR part 229) implements the Expedited Funds Availability Act (EFA Act) and the Check Clearing for the 21st Century Act (Check 21 Act).\\1\\ The Board implemented the EFA Act in...

  4. 78 FR 54952 - Petition for Waiver of Compliance

    Science.gov (United States)

    2013-09-06

    ... (FRA) for a waiver of compliance from certain provisions of the Federal railroad safety regulations contained at 49 CFR 229.81, Emergency Pole; shoe insulation. FRA assigned the petition Docket Number FRA-2003-16265. Title 49 CFR 229.81(b) requires that each locomotive equipped with third rail shoes...

  5. EST Table: FS920442 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS920442 E_FL_fufe_50G21_F_0 10/09/28 41 %/229 aa ref|XP_969213.1| PREDICTED: similar to artemis...2-PA 10/09/10 41 %/229 aa gi|91090768|ref|XP_969213.1| PREDICTED: similar to artemis protein [Tribolium castaneum] FS920671 fufe ...

  6. Integrated interpretation of geophysical and geological data: Tectonic implications. Tectonic pattern of the intraplate deformation area

    Digital Repository Service at National Institute of Oceanography (India)

    Neprochnov, Y.P.; Rao, D.G.; Buravtsev, A.A.; Levchenko, O.V.; Murthy, K.S.R.

    stream_size 4 stream_content_type text/plain stream_name Mem_Geol_Soc_India_1998_39_229.pdf.txt stream_source_info Mem_Geol_Soc_India_1998_39_229.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  7. Origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department); Origine des elements de la famille de l'uranium-235 observes dans la riviere Ellez a proximite du reacteur nucleaire experimental EL4 en cours de demantelement (Mont d'Arree - departement du Finistere). Resultats et premiers constats annee 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 ({sup 227}Ac), non born by its ascendents which are {sup 235}U and {sup 231}Pa is observed. This phenomenon is characterized by mass activities superior to these ones of {sup 235}U and able to reach these ones of {sup 238}U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil ({sup 210}Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  8. Evaluation of total effective dose due to certain environmentally placed naturally occurring radioactive materials using a procedural adaptation of RESRAD code.

    Science.gov (United States)

    Beauvais, Z S; Thompson, K H; Kearfott, K J

    2009-07-01

    Due to a recent upward trend in the price of uranium and subsequent increased interest in uranium mining, accurate modeling of baseline dose from environmental sources of radioactivity is of increasing interest. Residual radioactivity model and code (RESRAD) is a program used to model environmental movement and calculate the dose due to the inhalation, ingestion, and exposure to radioactive materials following a placement. This paper presents a novel use of RESRAD for the calculation of dose from non-enhanced, or ancient, naturally occurring radioactive material (NORM). In order to use RESRAD to calculate the total effective dose (TED) due to ancient NORM, a procedural adaptation was developed to negate the effects of time progressive distribution of radioactive materials. A dose due to United States' average concentrations of uranium, actinium, and thorium series radionuclides was then calculated. For adults exposed in a residential setting and assumed to eat significant amounts of food grown in NORM concentrated areas, the annual dose due to national average NORM concentrations was 0.935 mSv y(-1). A set of environmental dose factors were calculated for simple estimation of dose from uranium, thorium, and actinium series radionuclides for various age groups and exposure scenarios as a function of elemental uranium and thorium activity concentrations in groundwater and soil. The values of these factors for uranium were lowest for an adult exposed in an industrial setting: 0.00476 microSv kg Bq(-1) y(-1) for soil and 0.00596 microSv m(3) Bq(-1) y(-1) for water (assuming a 1:1 234U:238U activity ratio in water). The uranium factors were highest for infants exposed in a residential setting and assumed to ingest food grown onsite: 34.8 microSv kg Bq(-1) y(-1) in soil and 13.0 microSv m(3) Bq(-1) y(-1) in water.

  9. 两种稀土产品中放射性核素分析研究%ANALYSIS OF RADIONUCLIDES IN TWO RARE EARTH PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    周程; 孙恋君

    2009-01-01

    利用高纯锗γ谱仪对两个稀土产品氯化镧和氯化钇的样品进行能谱分析,研究经湿法冶炼工艺后的稀土产品中放射性核素的活度变化.结果表明,样品中存在天然放射性钍系和锕-铀系的核素,以及天然放射性核素~(138)La和~(176)Lu,但两个样品中所含的放射性核素不相同.氯化镧产品中锕-铀系和钍系核素放射性未达平衡,其主要子体~(224)Ra和~(227)Th的含量随时间发生明显变化,约60天达到平衡;而氯化钇产品没有这种现象.%This paper describes a study on raidoactivity change of rare-earth products after hydrometallurgy technology,using HPGe gamma spectrometer to analyze two rare earth products (LaCl_3 and YCl_3).The results show that in the two samples exist natural radionuclides of thorium series and actinium-uranium series as well as other natural radionuclides 138 La and 176 Lu.In the sample of lanthanum chloride the radioactivity of actinium-uranium series and thorium series has not reached balance,the contents of their main progenies ~(226)Ra and ~(227)Th obviously changes with the time,reaching balance 60 days later,while YCl_3 keeps stability.

  10. Determination of the extraction efficiency for $^{233}$U source $\\alpha$-recoil ions from the MLL buffer-gas stopping cell

    CERN Document Server

    von der Wense, Lars; Laatiaoui, Mustapha; Thirolf, Peter G

    2016-01-01

    Following the $\\alpha$ decay of $^{233}$U, $^{229}$Th recoil ions are shown to be extracted in a significant amount from the MLL buffer-gas stopping cell. The produced recoil ions and subsequent daughter nuclei are mass purified with the help of a customized quadrupole mass spectrometer. The combined extraction and mass-purification efficiency for $^{229}$Th$^{3+}$ is determined via MCP-based measurements and via the direct detection of the $^{229}$Th $\\alpha$ decay. A large value of $(10\\pm2)$\\% for the combined extraction and mass-purification efficiency of $^{229}$Th$^{3+}$ is obtained at a mass resolution of about 1 u/e. In addition to $^{229}$Th, also other $\\alpha$-recoil ions of the $^{233,232}$U decay chains are addressed.

  11. Production of soluble truncated spike protein of porcine epidemic diarrhea virus from inclusion bodies of Escherichia coli through refolding.

    Science.gov (United States)

    Piao, Da-Chuan; Lee, Yoon-Seok; Bok, Jin-Duck; Cho, Chong-Su; Hong, Zhong-Shan; Kang, Sang-Kee; Choi, Yun-Jaie

    2016-10-01

    The emergence of highly pathogenic variant porcine epidemic diarrhea virus (PEDV) strains, from 2013 to 2014, in North American and Asian countries have greatly threatened global swine industry. Therefore, development of effective vaccines against PEDV variant strains is urgently needed. Recently, it has been reported that the N-terminal domain (NTD) of S1 domain of PEDV spike protein is responsible for binding to the 5-N-acetylneuraminic acid (Neu5Ac), a possible sugar co-receptor. Therefore, the NTD of S1 domain could be an attractive target for the development of subunit vaccines. In this study, the NTD spanning amino acid residues 25-229 (S25-229) of S1 domain of PEDV variant strain was expressed in Escherichia coli BL21 (DE3) in the form of inclusion bodies (IBs). S25-229 IBs were solubilized in 20 mM sodium acetate (pH 4.5) buffer containing 8 M urea and 1 mM dithiothreitol with 95% yield. Solubilized S25-229 IBs were refolded by 10-fold flash dilution and purified by one-step cation exchange chromatography with >95% purity and 20% yield. The CD spectrum of S25-229 showed the characteristic pattern of alpha helical structure. In an indirect ELISA, purified S25-229 showed strong reactivity with mouse anti-PEDV sera. In addition, immunization of mice with 20 μg of purified S25-229 elicited highly potent serum IgG titers. Finally, mouse antisera against S25-229 showed immune reactivity with native PEDV S protein in an immunofluorescence assay. These results suggest that purified S25-229 may have potential to be used as a subunit vaccine against PEDV variant strains. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Hand Hygiene Saves Lives

    Medline Plus

    Full Text Available ... public health professionals. More > Hand Hygiene Saves Lives (5:10) Recommend on Facebook Tweet Share Compartir Hand ... High resolution [22.9 MB] Open Captioned [14.5 MB] Request a higher resolution file Copy the ...

  13. What information do Dutch midwives give clients about toxoplasmosis, listeriosis and cytomegalovirus prevention? An exploratory study of videotaped consultations.

    NARCIS (Netherlands)

    Pereboom, M.T.R.; Manniën, J.; Almkerk, K.D.J. van; Spelten, E.R.; Gitsels, J.T.; Martin, L.; Hutton, E.K.; Schellevis, F.G.

    2014-01-01

    Objective: To assess information provided by midwives about methods to prevent toxoplasmosis, listeriosis and cytomegalovirus, and whether the amount of provided information varied according to clients’ and midwives’ characteristics. Methods: Intake consultations with 229 clients in four midwifery p

  14. Permanent genetic resources added to molecular ecology resources database 1 August 2010 - 30 September 2010

    NARCIS (Netherlands)

    Aggarwal, P.K.; Allainguillaume, J.; Bajay, M.M.; Belder, den E.; Elderson, J.; Esselink, G.D.; Smulders, M.J.M.

    2011-01-01

    This article documents the addition of 229 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Acacia auriculiformis × Acacia mangium hybrid, Alabama argillacea, Anoplopoma fimbria, Aplochiton zebra, Brevicoryne brassicae, Bruguiera

  15. Experiment list: ERX149408 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available o sapiens || Sex=male || ClinicalHistory=cause of death: trauma || BMI=22.9kg_per_m2 || ClinicalInformation:... Premortem diagnosis of diabetes=No || Age=38 year || ClinicalInformation: Premor

  16. Hand Hygiene Saves Lives

    Medline Plus

    Full Text Available ... 22.9 MB] Open Captioned [14.5 MB] Request a higher resolution file Copy the code below ... future Salt Matters: Preserving Choice, Protecting Health More Information Hand Hygiene Clean Hands Basics Send Us Feedback ...

  17. Tra Albania e Italia: storie solide e confini liquidi

    Directory of Open Access Journals (Sweden)

    Lorenzo Mari

    2014-10-01

    Full Text Available Recensione di: Emma Bond e Daniele Comberiati (a cura di, Il confine liquido. Rapporti interculturali fra Italia e Albania, Nardò, Besa, 2013, 229 p., ISBN: 9788849708950, € 18,00.

  18. Effects of urban sprawl on sediment, surface water, and biota in the little Blackwater River, Blackwater National Wildlife Refuge, Dorchester County, Maryland

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Little Blackwater River drains a catchment area of approximately 11,229 hectares (27,748 acres). About 516 hectares (1,276 acres) in this watershed are currently...

  19. Interrelations of risk factors and low back pain in scaffolders

    NARCIS (Netherlands)

    A. Burdorf (Alex); L.A.M. Elders (Leo)

    2001-01-01

    textabstractOBJECTIVES: To assess with a cross sectional study the interrelations between physical, psychosocial, and individual risk factors and different end points of low back pain. METHODS: In total, 229 scaffolders and 59 supervisors completed a questionnaire about manual

  20. Cost–effectiveness of salmeterol in patients with chronic obstructive pulmonary disease: an economic evaluation

    National Research Council Canada - National Science Library

    JONES, PW; WILSON, K; SONDHI, S

    2003-01-01

    .... This 16-week study examined the cost-effectiveness of salmeterol in this patient group. Patients with a history of COPD were randomised to treatment with salmetrol 50 mcg (229 patients) or placebo (227 patients...

  1. SOAP in Practice: Learning Outcomes of a Cross-Institutional Innovation Project Conducted by Teachers, Student Teachers, and Teacher Educators

    NARCIS (Netherlands)

    Seezink, Audrey; Poell, Rob; Kirschner, Paul A.

    2010-01-01

    Seezink, A., Poell, R. F., & Kirschner, P. A. (2010). SOAP in practice: learning outcomes of a cross-institutional innovation project conducted by teachers, student teachers, and teacher educators. European Journal of Teacher Education, 33(3), 229-243.

  2. Madeira. Bullock cart

    OpenAIRE

    Unknown

    2003-01-01

    229 x 175 mm. Showing two passengers seated in a characteristic Maderia bullock cart or sled, with two drivers standing beside the animals and two other figures seated on the steps in the background. Photograph taken in the 1880s.

  3. Download this PDF file

    African Journals Online (AJOL)

    USER

    2017-03-13

    Mar 13, 2017 ... Ethiopian Journal of Environmental Studies & Management 10(2): 229 – 240, 2017. ISSN:1998- ..... occurrence of relatively thick soil profile. (Akinwumiju .... available online for users. .... Company, New York, USA. Strahler ...

  4. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... navigation Sign in Search Loading... Close Yeah, keep it Undo Close This video is unavailable. Watch Queue ... 704 views 2:29 Palliative Care: What Is It And Who Is It For? - Duration: 3:04. ...

  5. Nuclear physics: Elusive transition spotted in thorium

    Science.gov (United States)

    Safronova, Marianna

    2016-05-01

    The highly precise atomic clocks used in science and technology are based on electronic transitions in atoms. The discovery of a nuclear transition in thorium-229 raises hopes of making nuclear clocks a reality. See Article p.47

  6. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... navigation Sign in Search Loading... Close Yeah, keep it Undo Close This video is unavailable. Watch Queue ... 585 views 2:29 Palliative Care: What Is It And Who Is It For? - Duration: 3:04. ...

  7. Emotional Intelligence Meets Traditional Standards for an Intelligence.

    Science.gov (United States)

    Mayer, John D.; Caruso, David R.; Salovey, Peter

    1999-01-01

    Results of 2 studies involving 503 adults and 229 adolescents show that emotional intelligence, as measured by the Multifactor Emotional Intelligence Scale, a new ability test of emotional intelligence, meets 3 classical criteria of a standard intelligence. (SLD)

  8. Influence of Maternal Health Literacy on Healthy Pregnancy and ...

    African Journals Online (AJOL)

    User

    2011-05-20

    May 20, 2011 ... between maternal health literacy and pregnancy outcomes (r = .006, df = 229, P> .05). Based on ... that accounts for complexity, culture, individual empowerment and community ..... Jorm, A.F. (2000), Mental Health Disorders.

  9. Data of evolutionary structure change: 1BXCC-1XLDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1BXCC-1XLDA 1BXC 1XLD C A MYEPKPEHRFTFGLWTVGNVGRDPFGDAVRERLDPVYVG...GKARKVWDWVREPLNFMAAYAEDQGYGYRFALEPKPNEPRGDIYFATVGSMLALIHTLERPERFGLNPEFAHETMAGLNFVHAVAQALDAGKLLHIDLNGQRMNRFDQ...ALA CA 229 1XLD A 1XLDA... 1 1XLD A 1XLDA

  10. Dicty_cDB: Contig-U06090-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Strand = Plus / Plus Query: 38 cgttggntatctntacnccccnancaatgnaaaccaatntccatcaactgnanccgnana 97 |||||||||||||...||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 38 cgttggntatctntacnccccnancaatgnaaaccaatntccatcaactg...Plus / Plus Query: 38 cgttggntatctntacnccccnancaatgnaaaccaatntccatcaactgnanccgnan...) = 2e-79 Identities = 287/287 (100%) Strand = Plus / Minus Query: 38 cgttggntatctntacnccccna...||||| Sbjct: 288 cgttggntatctntacnccccnancaatgnaaaccaatntccatcaactgnanccgnana 229 Query: 98 ncaagnaatntcanac

  11. 76 FR 39813 - Notice of Funding Availability of Applications (NOFA) for Section 514 Farm Labor Housing Loans...

    Science.gov (United States)

    2011-07-07

    ...-6795, Julie Putnam. Minnesota State Office, 375 Jackson Street Building, Suite 410, St. Paul, MN 55101... 317, 10 Ferry Street, Concord, NH 03301-5004, (603) 223-6050, TDD (603) 229- 0536, Robert McCarthy...

  12. 75 FR 25833 - Notice of Funding Availability of Applications (NOFA) for Section 514 Farm Labor Housing Loans...

    Science.gov (United States)

    2010-05-10

    ... 48823, (517) 324-5192, TDD (517) 337-6795, Julie Putnam. Minnesota State Office, 375 Jackson Street...-6050, TDD (603) 229- 0536, Robert McCarthy. New Jersey State Office, 5th Floor North Suite 500, 8000...

  13. Association between osteoporotic fractures and quality of life based on the Korean Community Health Survey of 2010

    OpenAIRE

    Jun, Hyun-Ju; Kim, Ki-Jong; Lee, Jin-Su; Yang, Sueng-Hoon

    2015-01-01

    [Purpose] To assess the relationship between fractures and quality of life (QOL) of osteoporosis patients as well as the treatment methods and locations of fractures following osteoporosis diagnosis. [Subjects and Methods] Participants were selected from a cohort consisting of 229,229 subjects who participated in the Korean Community Health Survey. Those who were not diagnosed with osteoporosis by a doctor were excluded from the study (326) and the final analysis included 17,387 previously di...

  14. EST Table: FS787334 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS787334 E_FL_fcaL_21B10_R_0 10/09/28 47 %/229 aa ref|XP_975194.1| PREDICTED: similar to something about.../235 aa gnl|Amel|GB19080-PA 10/09/10 47 %/229 aa gi|91081571|ref|XP_975194.1| PREDICTED: similar to something about silencing protein 10 [Tribolium castaneum] FS823506 fcaL ...

  15. 46 CFR 162.050-15 - Designation of facilities.

    Science.gov (United States)

    2010-10-01

    ... the Student's t-distribution with (n-1) degrees of freedom for a confidence level of α = 0.01. If all... than or equal to 2.29 at a confidence level of 0.05. (2) The absolute value of Tn for one measurement... confidence level of 0.05. If the Tn value for one measurement exceeds 2.29, that measurement is not used...

  16. The major and trace element chemistry of fish and lake water within ...

    African Journals Online (AJOL)

    2016-01-01

    Jan 1, 2016 ... DORM-3 (Fish Protein) (National Research Council Canada,. 2007, 2008) were ..... 29 229±5 229. 163±11. 41.5±2.5. 944±53. 1 718±87. 16±1. 135±17. 631±44. VK ...... LIMBURG KE (1995) Otolith strontium trace environmental history of ... SECOR DH, HENDERSON-ARZAPALO A and PICCOLI PM (1995).

  17. Experiment list: SRX100474 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available chnology || antibody vendorid=sc-229 || treatment description=1 h with 0.02% Ethanol (Myers...) || protocol description=one 15-cycle round of PCR (Myers) || controlid=SL475 || labexpid=SL1207,...ndorid=sc-229 || treatment=EtOH_0.02pct || treatment description=1 h with 0.02% EtOH (Myers...) || protocol=PCR1x || protocol description=1-cycle of PCR (Myers) || controlid=SL475 || labexpid=

  18. 杂交小麦不同发育时期叶绿素蛋白复合体的变化%Change in chlorophyll-protein complexes of hybrid wheat in different developmental periods

    Institute of Scientific and Technical Information of China (English)

    李妮亚; 高培元; 等

    2001-01-01

    杂交小麦“901”在不同发育时期及不同叶位,叶片色素蛋白复合体含量均高于对照品种陕229,尤其表现在“901”的旗叶;而陕229的倒二叶在籽粒形成后期、灌浆期,略高于“901”。倒三叶在籽粒发育后期至成熟期“901”的含量要高于陕229。叶绿素蛋白复合体分析结果说明,在不同发育时期、不同叶位,“901”杂交小麦的捕光色素蛋白复合体含量均高于陕229,并且其捕光叶绿素a/b—蛋白复合体的cha/b值均低于陕229的相应复合体,表明“901”叶片色素蛋白复合体中含有较高的叶绿素b,尤其表现在籽粒形成后期的旗叶上。2个品种在不同发育时期,不同叶位之间,色素蛋白复合体组分上没有差异,仅表现在成熟期,陕229的倒三叶各色素带含量减少,并且消失1条叶绿素蛋白复合体带,初步认为此带是LHCP的寡聚体之一,而“901”比陕229晚7 d,倒二叶上表现出同样的现象,表明“901”叶片色素蛋白复合体抗衰老能力很强。%This study was showed that the amount of chlorophyll-protein complexes of hybrid wheat “901” was more than the contrast variety (Shaan 229) in the developmental period and leaves with different ages,especially flag leaf of hybrid wheat.However,the amount of chlorophyll-protein complexes of second leaf of Shaan 229 was more than the hybrid wheat at the late stage of grain filling period,however,third leaf of “901” was more than the Shaan 229 from the late stage of grain developmental to mature period.The amount of light harvesting chlorophyll-protein complexes (LHCP) of hybrid wheat was higher than Shaan 229 and chla/b ratio of hybrid wheat was lower than that of corresponding band of Shaan 229,it shown that the amount of chlorophyll b was higher than its contrast variety (Shaan 229),especially,flag leaf of “901”.There was no differences in the chl-protein complexes from hybrid wheat and

  19. Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder.

    Science.gov (United States)

    Musayev, Faik N; Di Salvo, Martino L; Saavedra, Mario A; Contestabile, Roberto; Ghatge, Mohini S; Haynes, Alexina; Schirch, Verne; Safo, Martin K

    2009-11-06

    Mutations in pyridoxine 5'-phosphate oxidase are known to cause neonatal epileptic encephalopathy. This disorder has no cure or effective treatment and is often fatal. Pyridoxine 5'-phosphate oxidase catalyzes the oxidation of pyridoxine 5'-phosphate to pyridoxal 5'-phosphate, the active cofactor form of vitamin B(6) required by more than 140 different catalytic activities, including enzymes involved in amino acid metabolism and biosynthesis of neurotransmitters. Our aim is to elucidate the mechanism by which a homozygous missense mutation (R229W) in the oxidase, linked to neonatal epileptic encephalopathy, leads to reduced oxidase activity. The R229W variant is approximately 850-fold less efficient than the wild-type enzyme due to an approximately 192-fold decrease in pyridoxine 5'-phosphate affinity and an approximately 4.5-fold decrease in catalytic activity. There is also an approximately 50-fold reduction in the affinity of the R229W variant for the FMN cofactor. A 2.5 A crystal structure of the R229W variant shows that the substitution of Arg-229 at the FMN binding site has led to a loss of hydrogen-bond and/or salt-bridge interactions between FMN and Arg-229 and Ser-175. Additionally, the mutation has led to an alteration of the configuration of a beta-strand-loop-beta-strand structure at the active site, resulting in loss of two critical hydrogen-bond interactions involving residues His-227 and Arg-225, which are important for substrate binding and orientation for catalysis. These results provide a molecular basis for the phenotype associated with the R229W mutation, as well as providing a foundation for understanding the pathophysiological consequences of pyridoxine 5'-phosphate oxidase mutations.

  20. Liquid Scintillation Counting of Environmental Radioisotopes: A Review of the Impact of Background Reduction

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, Matthew; Bernacki, Bruce E.; Erchinger, Jennifer L.; Finn, Erin C.; Fuller, Erin S.; Hoppe, Eric W.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Orrell, John L.; Panisko, Mark E.; Warren, Glen A.; Wright, Michael E.

    2016-03-09

    Liquid scintillation counting (LSC) is a versatile and commonplace method for radiometric measurement of charged particle emitting radionuclides. The LSC method provides utility in a range of environmental science applications including hydrological studies of water transport, anthropogenic releases of radionuclides into the environment, and vertical mixing rates within oceans. Instrumental measurement background is one limiting factor of radiometric measurement sensitivity. As part of the development of a custom low background LSC system located in a shallow underground laboratory at Pacific Northwest National Laboratory, a number of measurement applications of LSC have been considered and are summarized here. The focus is on determining which aspects of such measurements would gain the greatest benefit from the reduction of LSC backgrounds by a factor of 10-100 relative to values reported in the literature. Examples of benefits include lowering the minimum detectable activity, reducing the sample size required, and shortening the elapsed timeline of the processing and analysis sequence. In particular tritium, strontium, and actinium isotopes are examined as these isotopes cover a range of requirements related to the LSC measurement method (e.g., 3H: low energy; Sr: spectral deconvolution; Ac: alpha/beta discrimination).

  1. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  2. Rutherford's curriculum vitae, 1894-1907.

    Science.gov (United States)

    Cohen, M

    1995-06-01

    A single page, handwritten document was discovered when the Macdonald Physics building of McGill University in Montreal was gutted in 1978. This proved to be the draft of Ernest Rutherford's curriculum vitae (C.V.) covering the years 1894-1907, probably written in the autumn of 1906 when Rutherford was preparing to leave McGill. The C.V. contains 21 headings in chronological order, referring to research and other activities of Rutherford and his coauthors (especially Soddy and Barnes), plus a further set of headings relating to the associated investigations of Rutherford's team, including Eve and Hahn. A transcript of the document is provided, although in several places, Rutherford's handwriting is difficult to interpret, and the significance of his abbreviations is not always clear. Each of the items in the C.V. is discussed briefly in this review, in the light both of Rutherford's personal career and of the contribution of his team to the development and understanding of radioactivity. This contribution included the cause and nature of radioactivity (with Soddy), energy aspects of radioactive decay (with Barnes), elucidation of the uranium-radium, thorium and actinium series (Godlewski and Hahn), the radioactivity of the earth and atmosphere (Eve), the nature of the gamma rays (Eve) and, perhaps most important of all, the nature and properties of the alpha particle (Rutherford himself). The latter investigations led directly to Rutherford's later work in Manchester, including the nuclear model of the atom and artificial disintegration of the nucleus.

  3. Development of an Ultra-Low Background Liquid Scintillation Counter for Trace Level Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Erchinger, Jennifer L.; Orrell, John L.; Aalseth, Craig E.; Bernacki, Bruce E.; Douglas, Matthew; Finn, Erin C.; Fuller, Erin S.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Panisko, Mark E.; Shaff, Sarah M.; Warren, Glen A.; Wright, Michael E.

    2015-09-01

    Low-level liquid scintillation counting (LSC) has been established as one of the radiation detection techniques useful in elucidating environmental processes and environmental monitoring around nuclear facilities. The Ultra-Low Background Liquid Scintillation Counter (ULB-LSC) under construction in the Shallow Underground Laboratory at Pacific Northwest National Laboratory aims to further reduce the MDAs and/or required sample processing. Through layers of passive shielding in conjunction with an active veto and 30 meters water equivalent overburden, the background reduction is expected to be 10 to 100 times below typical analytic low-background liquid scintillation systems. Simulations have shown an expected background of around 14 counts per day. A novel approach to the light collection will use a coated hollow light guide cut into the inner copper shielding. Demonstration LSC measurements will show low-energy detection, spectral deconvolution, and alpha/beta discrimination capabilities, from trials with standards of tritium, strontium-90, and actinium-227, respectively. An overview of the system design and expected demonstration measurements will emphasize the potential applications of the ULB-LSC in environmental monitoring for treaty verification, reach-back sample analysis, and facility inspections.

  4. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    NA

    2004-11-22

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this modeling activity is to predict dissolved concentrations or solubility limits for 14 elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) important to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are in the form of tabulated functions with pH and log (line integral) CO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. The output data from this report are fundamental inputs for Total System Performance Assessment for the License Application (TSPA-LA) to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for all of the actinides. These models cover broad ranges of environmental conditions so that they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or otherwise addressed.

  5. Purification of lanthanides for double beta decay experiments

    Energy Technology Data Exchange (ETDEWEB)

    Polischuk, O. G. [Institute for Nuclear Research, MSP 03680 Kyiv, Ukraine and INFN, Section of Rome, La Sapienza, I-00185 Rome (Italy); Barabash, A. S. [Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Belli, P. [INFN, Section of Rome Tor Vergata, I-00133 Rome (Italy); Bernabei, R. [INFN, Section of Rome Tor Vergata, I-00133 Rome, Italy and Department of Physics, University of Rome Tor Vergata, I-00133 Rome (Italy); Boiko, R. S.; Danevich, F. A.; Mokina, V. M.; Poda, D. V.; Tretyak, V. I. [Institute for Nuclear Research, MSP 03680 Kyiv (Ukraine); Cappella, F.; Incicchitti, A. [INFN, Section of Rome La Sapienza, I-00185 Rome, Italy and Department of Physics, University of Rome La Sapienza, I-00185 Rome (Italy); Cerulli, R.; Laubenstein, M.; Nisi, S. [INFN, Gran Sasso National Laboratories, I-67100 Assergi (Aq) (Italy)

    2013-08-08

    There are several potentially double beta active isotopes among the lanthanide elements. However, even high purity grade lanthanide compounds contain {sup 238}U, {sup 226}Ra and {sup 232,228}Th typically on the level of ∼ (0.1 - 1) Bq/kg. The liquid-liquid extraction technique was used to remove traces of U, Ra and Th from CeO{sub 2}, Nd{sub 2}O{sub 3} and Gd{sub 2}O{sub 3}. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe γ spectrometry at the underground Gran Sasso National Laboratories of the INFN (Italy). After the purification the radioactive contamination of gadolinium oxide by Ra and Th was decreased at least one order of magnitude. The efficiency of the approach to purify cerium oxide from Ra was on same level, while the radioactive contamination of neodymium sample before and after the purification is below the sensitivity of analytical methods. The purification method is much less efficient for chemically very similar radioactive elements like lanthanum, lutetium and actinium. R and D of the methods to remove the pollutions with improved efficiency is in progress.

  6. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin.

    Science.gov (United States)

    Nour, S; El-Sharkawy, A; Burnett, W C; Horwitz, E P

    2004-12-01

    The objective of this work was to establish a new procedure for 228Ra determination of natural waters via preconcentration of radium on MnO2 and separation of its daughter, 228Ac, using Diphonix ion exchange resin. Following removal of potential interferences via passage through an initial Diphonix Resin column, the first daughter of 228Ra, 228Ac, is isolated by chromatographic separation via a second Diphonix column. A holding time of > 30 h for 228Ac ingrowth in between the two column separations ensures secular equilibrium. Barium-133 is used as a yield tracer. Actinium-228 is eluted from the second Diphonix Resin with 5 ml 1M 1-Hydroxyethane-1,1-diphosphonic acid (HEDPA) and quantified by addition of scintillation cocktail and LSC counting. Radium (and 133Ba) from the load and rinse solutions from the 2nd Diphonix column may be prepared for alpha spectrometry (for determination of 223Ra, 224Ra, and 226Ra) by BaSO4 microprecipitation and filtration. Decontamination tests indicate that U, Th, and Ra series nuclides do not interfere with these measurements, although high contents of 90Sr (90Y) require additional treatment for accurate measurement of 228Ra. Addition of stable Sr as a "hold back" carrier during the initial MnO2 preconcentration step was shown to remove most 90Sr interference.

  7. Soil and river sediments radionuclides monitoring at Aramar Experimental Center: an historical overview

    Energy Technology Data Exchange (ETDEWEB)

    Segre, Nadia; Fagundes, Rosane Correa, E-mail: nadia.segre@ctmsp.mar.mil.br [Centro Tecnologico da Marinha (CTM-SP/CEA/LARE), Ipero, SP (Brazil). Centro Experimental Aramar. Lab. Radioecologico; Moraes, Marco Antonio P.V. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    In order to evaluate possible effects to the environment resulting from the implementation of the Centro Tecnologico da Marinha - Centro Experimental Aramar (CTMSP-CEA) at Ipero in Sao Paulo state, Brazil, which came into operation in 1989, an Environmental Monitoring Program (PMA) was established in October, 1987. One of the aims of this program is to monitor the soil and river sediments radionuclides levels at CEA and beyond its boundary. The utilization of statistical tools to evaluate the results of radiometric environmental monitoring is a procedure required by National Nuclear Energy Commission (CNEN). The box plot is a simple statistical tool for displaying data. The central tendency and dispersion of the results as well as the observation of unusual results (outliers) in the dataset are easily visualized. Control chart is a graph that maps data and provides a picture of how a process is performing over time. A control chart always has a central line for the mean, an upper line for the upper control limit and a lower line for the lower control limit. Box plots and control charts were used to visualize the annual amount of natural uranium, lead-214, actinium-228 and lead-212 in soil and river sediment detected between 1987 and 2011, considering the measurements of all monitored places each year. This historical observation shows that, in average, the results obtained are below than the 1987-1988 levels (CEA's pre-operational) or below than the backgrounds radionuclides values. (author)

  8. Background radiation and individual dosimetry in the costal area of Tamil Nadu, India.

    Science.gov (United States)

    Matsuda, Naoki; Brahmanandhan, G M; Yoshida, Masahiro; Takamura, Noboru; Suyama, Akihiko; Koguchi, Yasuhiro; Juto, Norimichi; Raj, Y Lenin; Winsley, Godwin; Selvasekarapandian, S

    2011-07-01

    South coast of India is known as the high-level background radiation area (HBRA) mainly due to beach sands that contain natural radionuclides as components of the mineral monazite. The rich deposit of monazite is unevenly distributed along the coastal belt of Tamil Nadu and Kerala. An HBRA site that laid in 2×7 m along the sea was found in the beach of Chinnavillai, Tamil Nadu, where the maximum ambient dose equivalent reached as high as 162.7 mSv y(-1). From the sands collected at the HBRA spot, the high-purity germanium semi-conductor detector identified six nuclides of thorium series, four nuclides of uranium series and two nuclides belonging to actinium series. The highest radioactivity observed was 43.7 Bq g(-1) of Th-228. The individual dose of five inhabitants in Chinnavillai, as measured by the radiophotoluminescence glass dosimetry system, demonstrated the average dose of 7.17 mSv y(-1) ranging from 2.79 to 14.17 mSv y(-1).

  9. Coupling of Uranium and Thorium Series Isotope Systematics for Age Determination of Late Pleistocene Zircons using LA-ICP-MS

    Science.gov (United States)

    Sakata, S.; Hirakawa, S.; Iwano, H.; Danhara, T.; Hirata, T.

    2014-12-01

    Zircon U-Th-Pb dating method is one of the most important tools for estimating the duration of magmatism by means of coupling of uranium, actinium and thorium decay series. Using U-Pb dating method, its reliability is principally guaranteed by the concordance between 238U-206Pb and 235U-207Pb ages. In case of dating Quaternary zircons, however, the initial disequilibrium effect on 230Th and 231Pa should be considered. On the other hands, 232Th-208Pb dating method can be a simple but powerful approach for investigating the age of crystallization because of negligible influence from initial disequilibrium effect. We have developed a new correction model for accurate U-Pb dating of the young zircon samples by taking into consideration of initial disequilibrium and a U-Pb vs Th-Pb concordia diagram for reliable age calibration was successfully established. Hence, the U-Th-Pb dating method can be applied to various zircons ranging from Hadean (4,600 Ma) to Quaternary (~50 ka) ages, and this suggests that further detailed information concerning the thermal history of the geological sequences can be made by the coupling of U-Th-Pb, fission track and Ar-Ar ages. In this presentation, we will show an example of U-Th-Pb dating for zircon samples from Sambe Volcano (3 to 100 ka), southwest Japan and the present dating technique using LA-ICP-MS.

  10. Pulse-shape discrimination and energy quenching of alpha particles in Cs$_2$LiLaBr$_6$:Ce$^{3+}$

    CERN Document Server

    Mesick, Katherine E; Stonehill, Laura C

    2016-01-01

    Cs$_2$LiLaBr$_6$:Ce$^{3+}$ (CLLB) is an elpasolite scintillator that offers excellent linearity and gamma-ray energy resolution and sensitivity to thermal neutrons with the ability to perform pulse-shape discrimination (PSD) to distinguish gammas and neutrons. Our investigation of CLLB has indicated the presence of intrinsic radioactive alpha background that we have determined to be from actinium contamination of the lanthanum component. We measured the pulse shapes for gamma, thermal neutron, and alpha events and determined that PSD can be performed to separate the alpha background with a moderate figure of merit of 0.98. We also measured the electron-equivalent-energy of the alpha particles in CLLB and simulated the intrinsic alpha background from $^{227}$Ac to determine the quenching factor of the alphas. A linear quenching relationship $L_{\\alpha} = E_{\\alpha} \\times q + L_0$ was found at alpha particle energies above 5 MeV, with a quenching factor $q = 0.71$ MeVee/MeV and an offset $L_0 = - 1.19$ MeVee.

  11. Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution

    Science.gov (United States)

    Finn, R.; McDevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.

    2005-12-01

    In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented.

  12. An Ion Exchange Study of Possible Hydridized 5f Bonding in theActinides

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, R.M.; Street, Jr., K.; Seaborg, G.T.

    1951-08-28

    A study has been made of the elution behavior of curium(III), americium(III), plutonium(III), actinium(III), plutonium(IV), neptunium(IV), uraniuM(IV), thorium(IV), neptunium(V), plutonium (VI), uranium (VI), lanthanum(III), cerium(III), europium(III), ytterbium(III), ytterium(III), strontium(II), barium(II), radium(II), cesium(I) with 3.2 M, 6.2 M, 9.3 M, and 12.2 M HCl solutions from Dowex-50 cation exchange resin columns. These elutions show that in high concentrations of hydrochloric acid the actinides form complex ions with chloride ion to a much greater extent than the lanthanides. The strengths of the tripositive actinide complex ions apparently go in the order plutonium > americium> curium, although their ionic radii also decrease in this same order. To explain these results, a partial covalent character may be ascribed to the bonding in the transuranium complex ions. It is shown that a reasonable structure for such covalent bonding involves hybridization of the 5f orbitals in the actinide elements.

  13. Electronic structure and dynamics of ordered clusters with ME or RE ions on oxide surface

    Energy Technology Data Exchange (ETDEWEB)

    Kulagin, N.A., E-mail: nkulagin@bestnet.kharkov.u [Kharkiv National University for Radio Electronics, Avenue Shakespeare 6-48, 61045 Kharkiv (Ukraine)

    2011-03-15

    Selected data of ab initio simulation of the electronic structure and spectral properties of either cluster with ions of iron, rare earth or actinium group elements have been presented here. Appearance of doped Cr{sup +4} ions in oxides, Cu{sup +2} in HTSC, Nd{sup +2} in solids has been discussed. Analysis of experimental data for plasma created ordered structures of crystallites with size of about 10{sup -9} m on surface of separate oxides are given, too. Change in the spectroscopic properties of clusters and nano-structures on surface of strontium titanate crystals discussed shortly using the X-ray line spectroscopy experimental results. - Research highlights: External influence and variation of technology induce changes in valence of nl ions in compounds. Wave function of cluster presented as anti-symmetrical set of ions wave functions. The main equation describes the self-consistent field depending on state of all electrons of cluster. Level scheme of Cr{sup 4+} ions in octo- and tetra-site corresponds to doped oxides spectra after treatment. Plasma treatment effects in appearance of systems of unit crystallites with size of about 10{sup -6}-10{sup -9} m.

  14. Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Qian Rong Liu

    2014-01-01

    Full Text Available Piperlongumine (PL is recently found to kill cancer cells selectively and effectively via targeting reactive oxygen species (ROS responses. To further explore the therapeutic effects of PL in cancers, we investigated the role and mechanisms of PL in cancer cell migration. PL effectively inhibited the migration of human glioma (LN229 or U87 MG cells but not normal astrocytes in the scratch-wound culture model. PL did not alter EdU+-cells and cdc2, cdc25c, or cyclin D1 expression in our model. PL increased ROS (measured by DCFH-DA, reduced glutathione, activated p38 and JNK, increased IκBα, and suppressed NFκB in LN229 cells after scratching. All the biological effects of PL in scratched LN229 cells were completely abolished by the antioxidant N-acetyl-L-cysteine (NAC. Pharmacological administration of specific p38 (SB203580 or JNK (SP600125 inhibitors significantly reduced the inhibitory effects of PL on LN229 cell migration and NFκB activity in scratch-wound and/or transwell models. PL prevented the deformation of migrated LN229 cells while NAC, SB203580, or SP600125 reversed PL-induced morphological changes of migrated cells. These results suggest potential therapeutic effects of PL in the treatment and prevention of highly malignant tumors such as glioblastoma multiforme (GBM in the brain by suppressing tumor invasion and metastasis.

  15. The Growth Analysis in the Kernel Filling Process of K-Type Hybrid 901 and Its Parent Wheat

    Institute of Scientific and Technical Information of China (English)

    GONG Yue-hua; LIU Ying-zhou; GAO Jun-feng

    2005-01-01

    Using Matlab software, the grain filling process of hybrid wheat 901 and its parents was fitted by Richards equation W = A/(1 +Be-kt in order to study the characteristics of grain filling of the hybrid. The active grain growth period of the hybrid was 6 d longer than that of Shaan 229, and its final grain weight (43.7 g/1000 grains) was higher than that of Shaan229 (36.3 g/1 000 grains). N values of 901 and R205 were both less than 1, and their grain growth was faster in the early filling stage, while slower in the middle-late stage. N value of Shaan 229 was >1, and its growth was slower in the early stage and faster in the middle stage. The period of early stage of 901 was shorter and of middle-late stage was longer. The situation of Shaan 229 was totally reversed. For parents, the father plant R205 was similar to hybrid wheat 901, whereas its mother plant K3314A similar to Shaan 229. It has been found that Richards equation was more suitable for fitting the grain filling process of wheat than Logistic equation.

  16. Gene expression profile in a glioma cell line resistant to cell death induced by the chimeric tumor suppressor-1 (CTS-1), a dominant-positive variant of p53--the role of NFkappaB.

    Science.gov (United States)

    Seznec, Janina; Weit, Simone; Naumann, Ulrike

    2010-03-01

    The identification of genes involved in carcinogenesis and tumor progression is of great interest since these genes might be feasible as candidates for new tumor-targeted therapy strategies. Chimeric tumor suppressor-1 (CTS-1), an artificial synthetic variant of p53, resists common p53 inactivation and could therefore be defined as a dominant-positive p53 variant. Overexpression of CTS-1 induces caspase-independent cell death. We used whole-genome microarray expression analysis in a parental (229(P)) and a CTS-1-resistant glioma cell line (229(Res)) to analyze alterations in gene expression in Ad-CTS-1-infected and in uninfected parental and resistant cells. In total, 700 genes were differentially expressed in infected and 313 genes in uninfected 229(Res) versus 229(P) cells. Ingenuity Pathway Analysis determined a variety of differentially expressed genes in Ad-CTS-1-infected cells that were members of intracellular networks with central tumor-involved players such as nuclear factor-kappaB (NFkappaB), protein kinase B/AKT or transforming growth factor-beta. Here we focused on the function of NFkappaB in Ad-CTS-1-mediated cell death in glioma. NFkappaB was activated in Ad-CTS-1-infected 229(P) but not 229(Res) cells. NFkappaB activation was accompanied by the induction of cell death in parental cells. Inhibition of NFkappaB activity by expression of an IkappaB super repressor or upregulation of the NFkappaB-linked gene Bex protected parental cells to Ad-CTS-1-induced cell death, whereas knockdown of Bex sensitized both parental and resistant cells. Taken together, these data suggest that activation of the normally antiapoptotic protein NFkappaB does not always necessarily protect cells from apoptosis but, in the glioma cell lines tested so far, and in an environment where p53 is constitutively active, also leads to the induction of cell death.

  17. 组织因子/因子Ⅶ激活PI3K/Akt信号途径调控阿霉素诱导人胶质母细胞瘤细胞凋亡的研究%Tissue factor/FⅦ regulates doxorubicin-induced apoptosis in glioblastoma via activating PI3K/Akt signaling

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To investigate the role of tissue factor (TF) in chemotherapeutic reagent - induced apoptosis on human glioblastoma and explore its mechanism. Methods: The expression of TF was examined by Western blotting. The cytotoxicity of doxorubicin was determined by WST assay. The activation of Caspase-3 and PARP induced by adoxorubicin were tested by Western blotting. Results: Human glioblastoma ceil line U373MG expressed high level of TF while LN-229was with low-TF level. The chemotherapeutic reagent doxorubicin revealed stronger cytotoxic effect on high-TF U373MGcells than low-TF LN-229 cells. Enforced strong expression of TF was achieved by transfection of TF-pcDNA3 combinant on LN-229 cells in a dose-dependent manner. Enforced TF expression in transfected LN-229 cells not only impaired the doxorubicin-induced cleavage of Caspase-3 and PARP, but also inhibited the cytotoxic effect of doxorubicin. Furthermore,activation of Akt was strong in high-TF U373MG cells but weak in low-TF LN-229 cells. Incubation of factor Ⅶ (FⅦ) with enforced TF-expressing LN-229 cells increased the phosphorylation of Akt in a time-dependent manner. Conclusion: These results suggest that over-expression of TF on glioblastoma could inhibit doxorubicin-induced apoptosis. Interaction of FⅦand TF activates the downstream PI3K/Akt pathway. Tumor-derived over-expression of TF might play a role in chemotherapy resistance in glioblastoma, at lest in part, by activating PI3K/Akt-mediated survival and anti-apoptotic mechanism through theinteraction of TF/FⅦ signaling.

  18. Structure-guided systems-level engineering of oxidation-prone methionine residues in catalytic domain of an alkaline α-amylase from Alkalimonas amylolytica for significant improvement of both oxidative stability and catalytic efficiency.

    Science.gov (United States)

    Yang, Haiquan; Liu, Long; Shin, Hyun-dong; Li, Jianghua; Du, Guocheng; Chen, Jian

    2013-01-01

    High oxidative stability and catalytic efficiency are required for the alkaline α-amylases to keep the enzymatic performance under the harsh conditions in detergent industries. In this work, we attempted to significantly improve both the oxidative stability and catalytic efficiency of an alkaline α-amylase from Alkalimonas amylolytica by engineering the five oxidation-prone methionine residues around the catalytic domain via a systematic approach. Specifically, based on the tertiary structure analysis, five methionines (Met 145, Met 214, Met 229, Met 247 and Met 317) were individually substituted with oxidation-resistant threonine, isoleucine and alaline, respectively. Among the created 15 mutants, 7 mutants M145A, M145I, M214A, M229A, M229T, M247T and M317I showed significantly enhanced oxidative stability or catalytic efficiency. In previous work, we found that the replacement of M247 with leucine could significantly improve the oxidative stability. Thus, these 8 positive mutants (M145A, M145I, M214A, M229A, M229T, M247T, M247L and M317I) were used to conduct the second round of combinational mutations. Among the constructed 85 mutants (25 two-point mutants, 36 three-point mutants, 16 four-point mutants and 8 five-point mutants), the mutant M145I-214A-229T-247T-317I showed a 5.4-fold increase in oxidative stability and a 3.0-fold increase in catalytic efficiency. Interestingly, the specific activity, alkaline stability and thermal stability of this mutant were also increased. The increase of salt bridge and hydrogen bonds around the catalytic domain contributed to the significantly improved catalytic efficiency and stability, as revealed by the three-dimensional structure model of wild-type alkaline α-amylase and its mutant M145I-214A-229T-247T-317I. With the significantly improved oxidative stability and catalytic efficiency, the mutant M145I-214A-229T-247T-317I has a great potential as a detergent additive, and this structure-guided systems engineering

  19. A comprehensive database of Duchenne and Becker muscular dystrophy patients in Children's Hospital of Fudan University

    Directory of Open Access Journals (Sweden)

    Xi-hua LI

    2015-05-01

    Full Text Available Background China is one of the countries that have the largest number of patients suffering from Duchenne and Becker muscular dystrophy (DMD/BMD. Although the building of international DMD/BMD databases has laid a foundation for clinical drug development and clinical trials, it has not yet been carried out in China. In this study, a modified registry form of Remudy was applied to 229 DMD/BMD patients in order to establish a comprehensive database, which will lay the groundwork for international cooperation.  Methods A total of 229 DMD/BMD patients diagnosed by genetic testing or muscle biopsy admitted in Children's Hospital of Fudan University (CHFU during the period of August 2011 to December 2013 were enrolled in this study. The data included sex, age, age at diagnosis, geographic distribution of patients, DMD gene mutation types, family history, walking capability, cardiac and respiratory function, steroid treatment and rehabilitation intervention.  Results There were 194 DMD and 35 BMD male patients who were diagnosed at the age of 0-18 years, and among them, most patients were diagnosed at the age of > 3-4 (16.59%, 38/229 and > 7-8 (14.85%, 34/229 years. Exon deletion was the most frequent genetic mutations for DMD/BMD [65.46% (127/194 and 74.29% (26/35], respectively. Patients with a family history accounted for 23.14% (53/229. The rate of DMD registrants losing walking capability was 17.53% (34/194, and all the BMD registrants were able to walk. Cardiac functions were examined in 46.29% (106/229 DMD/BMD boys and respiratory functions were examined in 17.90% (41/229 DMD/BMD boys. The proportion of DMD patients receiving prednisone with dosage of 0.75 mg/(kg·d was 26.29% (51/194.  Conclusions This database describes in detail the genotype, clinical manifestation, diagnosis and treatment and rehabilitation status of 229 DMD/BMD patients in China. The database not only provides comprehensive information for DMD/BMD patient management

  20. Structure-guided systems-level engineering of oxidation-prone methionine residues in catalytic domain of an alkaline α-amylase from Alkalimonas amylolytica for significant improvement of both oxidative stability and catalytic efficiency.

    Directory of Open Access Journals (Sweden)

    Haiquan Yang

    Full Text Available High oxidative stability and catalytic efficiency are required for the alkaline α-amylases to keep the enzymatic performance under the harsh conditions in detergent industries. In this work, we attempted to significantly improve both the oxidative stability and catalytic efficiency of an alkaline α-amylase from Alkalimonas amylolytica by engineering the five oxidation-prone methionine residues around the catalytic domain via a systematic approach. Specifically, based on the tertiary structure analysis, five methionines (Met 145, Met 214, Met 229, Met 247 and Met 317 were individually substituted with oxidation-resistant threonine, isoleucine and alaline, respectively. Among the created 15 mutants, 7 mutants M145A, M145I, M214A, M229A, M229T, M247T and M317I showed significantly enhanced oxidative stability or catalytic efficiency. In previous work, we found that the replacement of M247 with leucine could significantly improve the oxidative stability. Thus, these 8 positive mutants (M145A, M145I, M214A, M229A, M229T, M247T, M247L and M317I were used to conduct the second round of combinational mutations. Among the constructed 85 mutants (25 two-point mutants, 36 three-point mutants, 16 four-point mutants and 8 five-point mutants, the mutant M145I-214A-229T-247T-317I showed a 5.4-fold increase in oxidative stability and a 3.0-fold increase in catalytic efficiency. Interestingly, the specific activity, alkaline stability and thermal stability of this mutant were also increased. The increase of salt bridge and hydrogen bonds around the catalytic domain contributed to the significantly improved catalytic efficiency and stability, as revealed by the three-dimensional structure model of wild-type alkaline α-amylase and its mutant M145I-214A-229T-247T-317I. With the significantly improved oxidative stability and catalytic efficiency, the mutant M145I-214A-229T-247T-317I has a great potential as a detergent additive, and this structure-guided systems

  1. Managing Space Situational Awareness Using the Space Surveillance Network

    Science.gov (United States)

    2013-11-14

    Spencer and Patrick S. Williams Department of Aerospace Engineering The Pennsylvania State University 229 Hammond Bldg...Department of Aerospace Engineering  The  Pennsylvania   State  University  229 Hammond Bldg.                         University Park, PA 16802...information between the state before and after a particular observation occurs, was derived by Hershey et al. [66] for Gaussian posterior and prior

  2. Comparison of Regional Vulnerability Factors for Department of Defense (DOD) Installations

    Science.gov (United States)

    2006-09-01

    Army AMC I 198 Fort Chaffee Arkansas Army NGB USARC A 199 Camp Shelby Mississippi Army NGB T 200 Camp Dodge Iowa Army NGB T 201 Hawthorne Army Depot...AAP Texas Army AMC I 228 Fort Nathaniel Greene Rhode Island Army USARC T 229 Red River Army Depot Texas Army AMC I 229 Camp Navajo Arizona Army NGB...Detroit Arsenal Michigan Army AMC I 286 Dugway Proving Ground Utah Army ATEC I 213 Hawthorne Army Depot Nevada Army AMC I 204 Holston AAP Tennessee

  3. Coronaviruses in brain tissue from patients with multiple sclerosis

    DEFF Research Database (Denmark)

    Dessau, R B; Lisby, G; Frederiksen, J L

    2001-01-01

    Brain tissue from 25 patients with clinically definite multiple sclerosis (MS) and as controls brain tissue from 36 patients without neurological disease was tested for the presence of human coronaviral RNA. Four PCR assays with primers specific for N-protein of human coronavirus strain 229E...... in the proportion of positive signals from the MS patients compared to controls. Evidence for a chronic infection with the human coronaviruses strain 229E or OC43 in brain tissue from patients with MS or controls has not been found in this study....

  4. 29 CFR 779.230 - Franchise and other arrangements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Franchise and other arrangements. 779.230 Section 779.230... Coverage Leased Departments, Franchise and Other Business Arrangements § 779.230 Franchise and other.... The quotation in § 779.229 from the Senate Report shows that Congress recognized that some...

  5. Kindergarten Teachers Speak out: "Too Much, Too Soon, Too Fast!"

    Science.gov (United States)

    Gallant, Patricia A.

    2009-01-01

    This article presents results of a study of 229 kindergarten teachers who completed a survey designed to gather information about the current state of Michigan kindergartens. In addition to detailed data that reveals teachers' literacy instructional practices, teachers provided written responses to the following open-ended questions: What are the…

  6. Review of Literature on High Power Microwave Pulse Biological Effects

    Science.gov (United States)

    2009-08-01

    City-Base, Texas. TABLE OF CONTENTS Page 1.0 BACKGROUND ... BACKGROUND Systems radiating pulsed energy at microwave frequencies (300 MHz to 300 GHz) are used for military communication, detection, and...15, 220-229. Ørstavik, K., Norheim, I., & Jørum, E. (2006). Pain and small-fiber neuropathy in patients with hypothyroidism . Neurology, 67, 786-791

  7. Life Domain Satisfaction: A Portugal-France Comparison

    Science.gov (United States)

    Ruiz Paiva, Maria Fatima; Neto, Felix; Munoz Sastre, Maria Teresa; Laumond-Salvatore, Nadine; Riviere, Sheila; Mullet, Etienne

    2009-01-01

    The study was aimed at replicating on a Portuguese sample the seven-factor model of life appraisal (physical autonomy, love life, family life, social life, occupational life, finances, and leisure life) that was suggested by Salvatore and Munoz Sastre ["Social Indicators Research" 53:229-255 (2001)]. A sample of 1,111 Portuguese…

  8. Go/NoGo performance in boys with Tourette syndrome

    DEFF Research Database (Denmark)

    Eichele, Heike; Eichele, Tom; Hammar, Asa;

    2010-01-01

    This study compared performance and performance monitoring in 19 boys with Tourette syndrome (TS) (12.64 years, +/- 2.05) and 19 age-matched controls (13.16 years, +/- 2.29) using a Go/NoGo task. The results indicated similar performance accuracy in the TS group and the control group. TS particip...

  9. Kindergarten Teachers Speak out: "Too Much, Too Soon, Too Fast!"

    Science.gov (United States)

    Gallant, Patricia A.

    2009-01-01

    This article presents results of a study of 229 kindergarten teachers who completed a survey designed to gather information about the current state of Michigan kindergartens. In addition to detailed data that reveals teachers' literacy instructional practices, teachers provided written responses to the following open-ended questions: What are the…

  10. Dicty_cDB: CFG871 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ce. 42 3e-05 3 BG711333 | ( S74728 ) antiquitin=26g turgor protein homolog [human, kidney, Peptide, 511 aa] ...pagrus schlegelii antiquiti... 229 9e-59 AY883858_1( AY883858 |pid:none) Sterkiella histriomuscorum turgor

  11. Implementation of Web-Based Learning in Colleges of Education: Barriers and Enablers

    Science.gov (United States)

    Surry, Daniel W.; Grubb, Adrian G.; Ensminger, David C.; Ouimette, Jenelle

    2009-01-01

    This paper describes the results of a survey to determine the factors that serve as barriers or enablers to the implementation of web-based learning in colleges of education. A total of 229 faculty members responded to the survey. Of these, 104 had never taught a web-based course while 125 had taught at least one online course. Results of the…

  12. 7 CFR Appendix to Part 227 - Apportionment of Funds for Nutrition Education and Training

    Science.gov (United States)

    2010-01-01

    ... PROGRAM Pt. 227, App. Appendix to Part 227—Apportionment of Funds for Nutrition Education and Training...,551 6,307 390,237 New Mexico 108,673 5,448 235 2,619 116,975 Oklahoma 229,166 3,969 1,916 8,639 243...

  13. Southeast Alaska forests: inventory highlights.

    Science.gov (United States)

    Sally Campbell; Willem W.S. van Hees; Bert. Mead

    2004-01-01

    This publication presents highlights of a recent southeast Alaska inventory and analysis conducted by the Pacific Northwest Research Station Forest Inventory and Analysis Program (USDA Forest Service). Southeast Alaska has about 22.9 million acres, of which two-thirds are vegetated. Almost 11 million acres are forest land and about 4 million acres have nonforest...

  14. 1228-IJBCS-Article-Honnoryf Tchibozo

    African Journals Online (AJOL)

    KODJIO NORBERT

    Auteur correspondant ; E-mail : tchibowo@yahoo.fr, Tél : 00(229) 21 03 78 31. RESUME. Cette étude a .... inondables et des points hauts (14 m) au Nord sur le Continental Terminal. ..... de DEA, UAC/FLASH, Benin, 65p. Amégée KP. 1992.

  15. Essences végétales et techniques de restauration des zones d ...

    African Journals Online (AJOL)

    SARAH

    30 sept. 2013 ... *Auteur correspondant, E-mail : vkindomihou@yahoo.fr; Tél:(+229) 95 02 30 58. Original ... écosystèmes soudano-sahéliens dégradés au Nord-Bénin. Méthodologie et ...... Langues, Arts et Sciences humaines (FLASH),.

  16. Perceptions of the Bologna Process: What Do Students' Choices Reveal?

    Science.gov (United States)

    Portela, Miguel; Sa, Carla; Alexandre, Fernando; Cardoso, Ana Rute

    2009-01-01

    A major element in the creation of the European area of higher education is the adoption of a common structure of degrees, implying in several countries the reduction of the duration of the first degree to 3 years, which is a controversial change. Cardoso et al. (CESifo Econ Stud 54(2): 229-247, 2008) have analyzed student confidence in the…

  17. 75 FR 52932 - Notice of Commission Meeting and Public Hearing

    Science.gov (United States)

    2010-08-30

    ... hydraulic design of 0.229 mgd to 1.0 mgd. Treated wastewater will continue to discharge to Pine Creek at...-191 CP-4. An application for renewal of the Abington Township Wastewater Treatment Plant (WWTP). The existing WWTP will continue to discharge treated effluent at an annual average flow of 3.91 million...

  18. 76 FR 18966 - Listing Standards for Compensation Committees

    Science.gov (United States)

    2011-04-06

    ... the compensation consultant, legal counsel, or other adviser; The policies and procedures of the... COMMISSION 17 CFR Parts 229 and 240 RIN 3235-AK95 Listing Standards for Compensation Committees AGENCY... issuer that is not in compliance with Section 10C's compensation committee and compensation...

  19. GEOCHRONOMETRY & ISOTOPE GEOLOGY

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>20141014Wang Hairan(State Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Xi’an710069,China);Zhao Hongge Theory and Application of Zircon U-Pb Isotope Dating Technique(Geology and Resources,ISSN1671-1947,CN21-1458/P,22(3),2013,p.229

  20. The 1980-81 AFOSR-HTTM (Heat Transfer and Turbulence Mechanics)-Stanford Conference on Complex Turbulent Flows: Comparison of Computation and Experiment. Volume 1. Objectives, Evaluation of Data, Specifications of Test Cases, Discussion, and Position Papers

    Science.gov (United States)

    1980-09-01

    boundary condition for com’putations made with an ellipric treatment. The conclugi(c was that persona providing elliptic analyses dould probably prefer...Computor Bergman %ail Stop 229-1 Moffett Field, CA 94035 B.30 Dr. Claude Berner Aerospace & Mech. Eng. Dept. Discussor The University of Arizona Tucson