WorldWideScience

Sample records for actinium 227

  1. Separation of Actinium 227 from the uranium minerals

    International Nuclear Information System (INIS)

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  2. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  3. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  4. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  5. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Spectroscopic and computational investigation of actinium coordination chemistry.

    Science.gov (United States)

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  7. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    International Nuclear Information System (INIS)

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  8. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    International Nuclear Information System (INIS)

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  9. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  10. AAS 227: Day 2

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This week were at the 227th AAS Meeting in Kissimmee, FL. Along with several fellow authors from astrobites.com, I will bewritingupdates on selectedevents at themeeting and posting at the end of each day. Follow along here or atastrobites.com, or catch ourlive-tweeted updates from the@astrobites Twitter account. The usual posting schedule for AAS Nova will resumenext week.Welcome to Day 2 of the winter American Astronomical Society (AAS) meeting in Kissimmee! Several of us are attending the conference this year, and we will report highlights from each day here on astrobites. If youd like to see more timely updates during the day, we encourage you to follow @astrobites on twitter or search the #aas227 hashtag.Plenary Session: Black Hole Physics with the Event Horizon Telescope (by Susanna Kohler)If anyone needed motivation to wake up early this morning, they got it in the form of Feryal Ozel (University of Arizona) enthralling us all with exciting pictures, videos, and words about black holes and the Event Horizon Telescope. Ozel spoke to a packed room (at 8:30am!) about where the project currently stands, and where its heading in the future.The EHT has pretty much the coolest goal ever: actually image the event horizons of black holes in our universe. The problem is that the largest black hole we can look at (Sgr A*, in the center of our galaxy) has an event horizon size of 50 as. For this kind of resolution roughly equivalent to trying to image a DVD on the Moon! wed need an Earth-sized telescope. EHT has solved this problem by linking telescopes around the world, creating one giant, mm-wavelength effective telescope with a baseline the size of Earth.Besides producing awesome images, the EHT will be able to test properties of black-hole spacetime, the no-hair theorem, and general relativity (GR) in new regimes.Ozel walked us through some of the theory prep work we need to do now in order to get the most science out of the EHT, including devising new

  11. AAS 227: Day 1

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This week were at the 227th AAS Meeting in Kissimmee, FL. Along with several fellow authors from astrobites.com, I will bewritingupdates on selectedevents at themeeting and posting at the end of each day. Follow along here or at astrobites.com, or catch ourlive-tweeted updates from the @astrobites Twitter account. The usual posting schedule for AAS Nova will resumenext week.Things kicked off last night at our undergraduate reception booth. Thanks to all of you who stopped by we were delightedto have so many people tell us that they already know about and useastrobites, and we were excited to introduce a new cohort of students at AAS to astrobites for the first time.Tuesday morning was the official start of the meeting. Here are just a few of the talks and workshops astrobiters attended today.Opening Address (by Becky Smethurst)The President of the AAS, aka our fearless leader Meg Urry kicked off the meeting this morning at the purely coffee powered hour of 8am this morning. She spoke about the importance of young astronomers at the meeting (heres looking at you reader!) and also the importance of the new Working Group for Accessibility and Disabilities (aka WGAD pronounced like wicked) at the AAS. The Society has made extra effort this year to make the conference accessible to all,a message which was very well received by everyone in attendance.Kavli Lecture: New Horizons Alan Stern (by Becky Smethurst)We were definitely spoilt with the first Plenary lecture at this years conference Alan Stern gave us a a review of the New Horizons mission of the Pluto Fly By (astrobites covered the mission back in July with this post). We were treated to beautiful images, wonderful results and a foray into geology.Before (Hubble) and after #NewHorizons. #thatisall #science #astro alanstern #aas227 pic.twitter.com/kkMt6RsSIR Science News (@topsciencething) January 5, 2016Some awesome facts from the lecture that blew my mind:New Horizons is now 2AU (!) beyond Pluto

  12. AAS 227: Day 3

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This week were at the 227th AAS Meeting in Kissimmee, FL. Along with several fellow authors from astrobites.com, I will bewritingupdates on selectedevents at themeeting and posting at the end of each day. Follow along here or atastrobites.com, or catch ourlive-tweeted updates from the@astrobites Twitter account. The usual posting schedule for AAS Nova will resumenext week.Welcome to Day 3 of the winter American Astronomical Society (AAS) meeting in Kissimmee! Several of us are attending the conference this year, and we will report highlights from each day here on astrobites. If youd like to see more timely updates during the day, we encourage you to follow @astrobites on twitter or search the #aas227 hashtag.Henry Norris Russell Lecture: Viewing the Universe with Infrared Eyes: The Spitzer Space Telescope (by Erika Nesvold)The Henry Norris Russell Award is the highest honor given by the AAS, for a lifetime of eminence in astronomy research. This years award went to Giovanni Fazio of the Harvard-Smithsonian Center for Astrophysics. Fazio became a leader in gamma ray astronomy before switching mid-career to the study of infrared astronomy, and he gave his award lecture on the latter subject, specifically on the Spitzer Space Telescope, one of the most successful infrared telescopes of all time.Artists rendering of the Spitzer space telescope. [NASA/JPL-Caltech]Spitzer has been operating for more than twelve years, and has resulted in over six thousand papers in refereed journals in that time. The telescope sits in an Earth-trailing orbit around the Sun, and is now farther from the Earth (1.4 AU) than the Earth is from the Sun. Fazio gave the audience a fascinating overview of the science done by Spitzer over more than a decade. One of the most productive areas of research for Spitzer is the study of exoplanets, which hadnt even been discovered when the Spitzer Telescope was first conceived. Spitzers high sensitivity and ability to observe exoplanets over

  13. AAS 227: Day 3

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This week were at the 227th AAS Meeting in Kissimmee, FL. Along with several fellow authors from astrobites.com, I will bewritingupdates on selectedevents at themeeting and posting at the end of each day. Follow along here or atastrobites.com, or catch ourlive-tweeted updates from the@astrobites Twitter account. The usual posting schedule for AAS Nova will resumenext week.Welcome to Day 3 of the winter American Astronomical Society (AAS) meeting in Kissimmee! Several of us are attending the conference this year, and we will report highlights from each day here on astrobites. If youd like to see more timely updates during the day, we encourage you to follow @astrobites on twitter or search the #aas227 hashtag.Henry Norris Russell Lecture: Viewing the Universe with Infrared Eyes: The Spitzer Space Telescope (by Erika Nesvold)The Henry Norris Russell Award is the highest honor given by the AAS, for a lifetime of eminence in astronomy research. This years award went to Giovanni Fazio of the Harvard-Smithsonian Center for Astrophysics. Fazio became a leader in gamma ray astronomy before switching mid-career to the study of infrared astronomy, and he gave his award lecture on the latter subject, specifically on the Spitzer Space Telescope, one of the most successful infrared telescopes of all time.Artists rendering of the Spitzer space telescope. [NASA/JPL-Caltech]Spitzer has been operating for more than twelve years, and has resulted in over six thousand papers in refereed journals in that time. The telescope sits in an Earth-trailing orbit around the Sun, and is now farther from the Earth (1.4 AU) than the Earth is from the Sun. Fazio gave the audience a fascinating overview of the science done by Spitzer over more than a decade. One of the most productive areas of research for Spitzer is the study of exoplanets, which hadnt even been discovered when the Spitzer Telescope was first conceived. Spitzers high sensitivity and ability to observe exoplanets over

  14. AAS 227: Day 4

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This week were at the 227th AAS Meeting in Kissimmee, FL. Along with several fellow authors from astrobites.com, I will bewritingupdates on selectedevents at themeeting and posting at the end of each day. Follow along here or atastrobites.com, or catch ourlive-tweeted updates from the@astrobites Twitter account. The usual posting schedule for AAS Nova will resumenext week.Welcome to Day 4 of the winter American Astronomical Society (AAS) meeting in Kissimmee! Several of us are attending the conference this year, and we will report highlights from each day here on astrobites. If youd like to see more timely updates during the day, we encourage you to follow @astrobites on twitter or search the #aas227 hashtag.Helen B. Warner Prize: Origins of Structure in Planetary Systems (by Erika Nesvold)Another excellent prize lecture started off todays sessions. The Helen B. Warner Prize is awarded for achievement in observational or theoretical astrophysics by a young researcher (no more than eight years after their Ph.D.). This years Warner Prize was presented to Ruth Murray-Clay of UC Santa Barbara. For her award lecture, Murray-Clay told us all about planetary system architecture: the number, masses, and orbits of planets in a given system.Ruth Murray-Clay [photo from http://web.physics.ucsb.edu/ ~murray/biocv.html]The underlying question motivating this type of research is: How rare is the Solar System? In other words, how likely is it that a given planetary system will have rocky planets close to their star, gas giants farther out, and ice giants at the outer reaches of the system? Answering this question will help us solve the physics problem of how and where planets form, and will also help us on our search for other planets like Earth.The data on exoplanet population from transit and radial velocity observations and from direct imaging tell us that our Solar System is not common (many systems we observe have much more eccentric gas giants), but that doesnt

  15. AAS 227: Day 4

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This week were at the 227th AAS Meeting in Kissimmee, FL. Along with several fellow authors from astrobites.com, I will bewritingupdates on selectedevents at themeeting and posting at the end of each day. Follow along here or atastrobites.com, or catch ourlive-tweeted updates from the@astrobites Twitter account. The usual posting schedule for AAS Nova will resumenext week.Welcome to Day 4 of the winter American Astronomical Society (AAS) meeting in Kissimmee! Several of us are attending the conference this year, and we will report highlights from each day here on astrobites. If youd like to see more timely updates during the day, we encourage you to follow @astrobites on twitter or search the #aas227 hashtag.Helen B. Warner Prize: Origins of Structure in Planetary Systems (by Erika Nesvold)Another excellent prize lecture started off todays sessions. The Helen B. Warner Prize is awarded for achievement in observational or theoretical astrophysics by a young researcher (no more than eight years after their Ph.D.). This years Warner Prize was presented to Ruth Murray-Clay of UC Santa Barbara. For her award lecture, Murray-Clay told us all about planetary system architecture: the number, masses, and orbits of planets in a given system.Ruth Murray-Clay [photo from http://web.physics.ucsb.edu/ ~murray/biocv.html]The underlying question motivating this type of research is: How rare is the Solar System? In other words, how likely is it that a given planetary system will have rocky planets close to their star, gas giants farther out, and ice giants at the outer reaches of the system? Answering this question will help us solve the physics problem of how and where planets form, and will also help us on our search for other planets like Earth.The data on exoplanet population from transit and radial velocity observations and from direct imaging tell us that our Solar System is not common (many systems we observe have much more eccentric gas giants), but that doesnt

  16. AAS 227: Day 2

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This week were at the 227th AAS Meeting in Kissimmee, FL. Along with several fellow authors from astrobites.com, I will bewritingupdates on selectedevents at themeeting and posting at the end of each day. Follow along here or atastrobites.com, or catch ourlive-tweeted updates from the@astrobites Twitter account. The usual posting schedule for AAS Nova will resumenext week.Welcome to Day 2 of the winter American Astronomical Society (AAS) meeting in Kissimmee! Several of us are attending the conference this year, and we will report highlights from each day here on astrobites. If youd like to see more timely updates during the day, we encourage you to follow @astrobites on twitter or search the #aas227 hashtag.Plenary Session: Black Hole Physics with the Event Horizon Telescope (by Susanna Kohler)If anyone needed motivation to wake up early this morning, they got it in the form of Feryal Ozel (University of Arizona) enthralling us all with exciting pictures, videos, and words about black holes and the Event Horizon Telescope. Ozel spoke to a packed room (at 8:30am!) about where the project currently stands, and where its heading in the future.The EHT has pretty much the coolest goal ever: actually image the event horizons of black holes in our universe. The problem is that the largest black hole we can look at (Sgr A*, in the center of our galaxy) has an event horizon size of 50 as. For this kind of resolution roughly equivalent to trying to image a DVD on the Moon! wed need an Earth-sized telescope. EHT has solved this problem by linking telescopes around the world, creating one giant, mm-wavelength effective telescope with a baseline the size of Earth.Besides producing awesome images, the EHT will be able to test properties of black-hole spacetime, the no-hair theorem, and general relativity (GR) in new regimes.Ozel walked us through some of the theory prep work we need to do now in order to get the most science out of the EHT, including devising new

  17. AAS 227: Welcome!

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Greetings from the 227th American Astronomical Society meeting in Kissimmee, Florida! This week, along with several fellow authors from astrobites, Iwill bewritingupdates on selectedevents at themeeting and posting at the end of each day. You can follow along here or atastrobites.com, or catch ourlive-tweeted updates from the@astrobites Twitter account. The usual posting schedule for AAS Nova will resumenext week.If youre an author or referee (or plan to be!) and youre here at the meeting, consider joining us at our Author and Referee Workshop on Wednesday in the Tallahassee room, where well be sharingsome of the exciting new features of the AAS journals. You can drop intoeither of the two-hour sessions(10 AM 12 PM or 1 PM 3 PM), and there will be afree buffet lunch at noon.Heres the agenda:Morning SessionTopic Speaker10:00 am 10:05 amIntroductionsJulie Steffen10:05 am 10:35 amChanges at AAS Journals; How to Be a Successful AAS AuthorEthan Vishniac10:35 am 11:00 amThe Peer Review ProcessButler Burton11:00 am 11:15 amAAS Nova: Sharing AAS Authors Research with the Broader CommunitySusanna Kohler11:15 am 11:30 amFixing Software and Instrumentation Publishing: New Paper Styles in AAS JournalsChris Lintott11:30 am 11:45 amMaking Article Writing Easier with the New AASTeX v6.0Greg Schwarz11:45 am 12:00 pmBringing JavaScript and Interactivity to Your AAS Journal FiguresGus MuenchLunch SessionTopic Speaker12:00 pm 12:15 pmUnified Astronomy ThesaurusKatie Frey12:15 pm 12:30 pmAAS/ADS ORCID Integration ToolAlberto Accomazzi12:30 pm 12:45 pmWorldWide Telescope and Video AbstractsJosh Peek12:45 pm 01:00 pmArizona Astronomical Data Hub (AADH)Bryan HeidornAfternoon SessionTopic Speaker01:00 pm 01:05 pmIntroductionsJulie Steffen01:05 pm 01:35 pmChanges at AAS Journals; How to Be a Successful AAS AuthorEthan Vishniac01:35 pm 02:00 pmThe Peer Review ProcessButler Burton02:00 pm 02:15 pmAAS Nova: Sharing AAS Authors Research with the Broader CommunitySusanna Kohler02:15 pm 02:30 pm

  18. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    International Nuclear Information System (INIS)

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  19. 7 CFR 227.5 - Program funding.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Program funding. 227.5 Section 227.5 Agriculture... CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM General § 227.5 Program funding. (a... agencies shall maintain their present level of funding for existing nutrition education and...

  20. 49 CFR 238.227 - Suspension system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Suspension system. 238.227 Section 238.227 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.227 Suspension system. On or after November 8, 1999— (a) All passenger equipment...

  1. 48 CFR 227.7103-9 - Copyright.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Copyright. 227.7103-9..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-9 Copyright. (a) Copyright license. (1) The clause at 252.227-7013, Rights in Technical...

  2. 7 CFR 227.40 - Program information.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Program information. 227.40 Section 227.40 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM Miscellaneous § 227.40...

  3. 7 CFR 227.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 227.3 Section 227.3 Agriculture... CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM General § 227.3 Administration. (a) Within the Department, FNS shall act on behalf of the Department in the administration of the Program....

  4. 36 CFR 223.227 - Sale advertisement.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Sale advertisement. 223.227... DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Special Forest Products Advertisement and Bids § 223.227 Sale advertisement. (a) The Forest Service shall advertise any special forest products sales with an appraised...

  5. 49 CFR 227.115 - Hearing protectors.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Hearing protectors. 227.115 Section 227.115 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad...

  6. 27 CFR 44.227 - Customs procedure.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Customs procedure. 44.227..., WITHOUT PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Drawback of Tax § 44.227 Customs procedure. The customs... having inspected the articles and supervised the lading thereof on the export carrier, the...

  7. 48 CFR 227.7203-9 - Copyright.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Copyright. 227.7203-9..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-9 Copyright. (a) Copyright license. (1) The clause...

  8. 7 CFR 1280.227 - Confidentiality.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidentiality. 1280.227 Section 1280.227 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH,...

  9. 40 CFR 227.5 - Prohibited materials.

    Science.gov (United States)

    2010-07-01

    ... 227.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CRITERIA FOR THE EVALUATION OF PERMIT APPLICATIONS FOR OCEAN DUMPING OF MATERIALS Environmental Impact § 227.5... environmental impact criteria of this subpart B; (d) Persistent inert synthetic or natural materials which...

  10. 40 CFR 227.4 - Criteria for evaluating environmental impact.

    Science.gov (United States)

    2010-07-01

    ... impact. 227.4 Section 227.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN... Impact § 227.4 Criteria for evaluating environmental impact. This subpart B sets specific environmental... of direct environmental impact....

  11. 29 CFR 553.227 - Outside employment.

    Science.gov (United States)

    2010-07-01

    ... Enforcement Employees of Public Agencies Tour of Duty and Compensable Hours of Work Rules § 553.227 Outside... overtime compensation. (f) The principles in paragraphs (d) and (e) of this section with respect to...

  12. 48 CFR 227.7103-6 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... software or computer software documentation (see 227.72), commercial items (see 227.7102-3), existing works (see 227.7105), special works (see 227.7106), or when contracting under the Small Business Innovation... Software Previously Delivered to the Government, in solicitations when the resulting contract will...

  13. AcEST: CL227Contig1 [AcEST

    Lifescience Database Archive (English)

    Full Text Available CL227Contig1 1060 9 Adiantum capillus-veneris contig: CL227contig1 sequence. Link to clone list Show CL2...27Contig1 Contig ID CL227Contig1 Length 1060 Number of clones 9 Definition Adiantum capillus-veneris contig: CL2

  14. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Science.gov (United States)

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  15. 7 CFR 227.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM General § 227.2 Definitions. (a... section 17 of the National School Lunch Act, as amended. (c) Child Nutrition Programs means any or all of... of the Child Nutrition Act of 1966, as amended. (n) School means: (1) An educational unit of...

  16. 25 CFR 227.19 - Division orders.

    Science.gov (United States)

    2010-04-01

    ... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING Rents and Royalties § 227.19 Division orders. (a... it to the supervisor for his consideration. The right is reserved for the supervisor to cancel...

  17. 48 CFR 2453.227 - Patents, data, and copyrights.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Patents, data, and copyrights. 2453.227 Section 2453.227 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS FORMS Prescription of Forms 2453.227 Patents, data, and copyrights....

  18. 20 CFR 227.5 - Employer tax credits.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Employer tax credits. 227.5 Section 227.5... SUPPLEMENTAL ANNUITIES § 227.5 Employer tax credits. Employers are entitled to tax credits if they pay non.... The tax credits for each month equal the sum of the reductions for employer pensions in...

  19. 34 CFR 300.227 - Direct services by the SEA.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Direct services by the SEA. 300.227 Section 300.227... CHILDREN WITH DISABILITIES Local Educational Agency Eligibility § 300.227 Direct services by the SEA. (a) General. (1) An SEA must use the payments that would otherwise have been available to an LEA or to a...

  20. 7 CFR 227.42 - Grant closeout procedures.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Grant closeout procedures. 227.42 Section 227.42 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM Miscellaneous § 227.42...

  1. New method for large scale production of medically applicable Actinium-225 and Radium-223

    International Nuclear Information System (INIS)

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  2. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    International Nuclear Information System (INIS)

    A technique of selenium purification from 232Th, 238U, 226,228Ra, 227Ac and 40K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  3. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  4. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  5. 48 CFR 52.227-3 - Patent Indemnity.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Patent Indemnity. 52.227-3... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.227-3 Patent Indemnity. As prescribed in 27.201-2(c)(1), insert the following clause: Patent Indemnity (APR 1984) (a)...

  6. 14 CFR 417.227 - Toxic release hazard analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Toxic release hazard analysis. 417.227..., DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.227 Toxic release hazard... hazard associated with toxic release and demonstrate compliance with the public risk criterion of §...

  7. 48 CFR 1552.227-76 - Project employee confidentiality agreement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Project employee confidentiality agreement. 1552.227-76 Section 1552.227-76 Federal Acquisition Regulations System ENVIRONMENTAL... electrical services, provisions which shall conform substantially to the language of this clause,...

  8. 49 CFR 227.117 - Hearing protector attenuation.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating Employees. § 227.117 Hearing protector attenuation. (a) A railroad shall evaluate hearing... exposure to an 8-hour TWA of 90 decibels or lower, as required by § 227.115. (c) For employees who...

  9. 25 CFR 227.12 - Mineral reserves in nonmineral entries.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Mineral reserves in nonmineral entries. 227.12 Section 227.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING How to Acquire...

  10. 12 CFR 227.25 - Unfair balance computation method.

    Science.gov (United States)

    2010-01-01

    ... under 12 CFR 226.12 or 12 CFR 226.13; or (2) Adjustments to finance charges as a result of the return of... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Unfair balance computation method. 227.25... Practices Rule § 227.25 Unfair balance computation method. (a) General rule. Except as provided in...

  11. 14 CFR 121.227 - Pressure cross-feed arrangements.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pressure cross-feed arrangements. 121.227 Section 121.227 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... cross-feed arrangements. (a) Pressure cross-feed lines may not pass through parts of the airplane...

  12. 14 CFR 125.227 - Cockpit voice recorders.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Cockpit voice recorders. 125.227 Section... Requirements § 125.227 Cockpit voice recorders. (a) No certificate holder may operate a large turbine engine... cockpit voice recorder is installed in that airplane and is operated continuously from the start of...

  13. 7 CFR 227.44 - Management evaluations and reviews.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Management evaluations and reviews. 227.44 Section 227.44 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM...

  14. 22 CFR 227.205 - Professional and technical services.

    Science.gov (United States)

    2010-04-01

    ..., drafting of a legal document accompanying a bid or proposal by a lawyer is allowable. Similarly, technical... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Professional and technical services. 227.205... Activities by Own Employees § 227.205 Professional and technical services. (a) The prohibition on the use...

  15. 22 CFR 227.300 - Professional and technical services.

    Science.gov (United States)

    2010-04-01

    ... and analysis directly applying any professional or technical discipline. For example, drafting or a... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Professional and technical services. 227.300... Activities by Other Than Own Employees § 227.300 Professional and technical services. (a) The prohibition...

  16. 25 CFR 227.22 - Diligence and prevention of waste.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Diligence and prevention of waste. 227.22 Section 227.22... prevention of waste. The lessee shall exercise diligence in drilling and operating wells for oil and gas on... prevention of waste of oil or gas developed on the land, or the entrance of water through wells drilled...

  17. 20 CFR 227.4 - Reduction for employer pension.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Reduction for employer pension. 227.4 Section... COMPUTING SUPPLEMENTAL ANNUITIES § 227.4 Reduction for employer pension. (a) General. The supplemental annuity for each month is reduced by the amount of any private pension the employee is receiving for...

  18. 7 CFR 227.43 - Participation of adults.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Participation of adults. 227.43 Section 227.43 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM Miscellaneous §...

  19. 48 CFR 227.7103-5 - Government rights.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government rights. 227..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-5 Government rights. The standard license rights that a licensor grants to the Government...

  20. 48 CFR 227.7103-4 - License rights.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License rights. 227.7103-4..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7103-4 License rights. (a) Grant of license. The Government obtains rights in technical...

  1. 48 CFR 227.7203-5 - Government rights.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government rights. 227..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-5 Government rights. The standard license rights...

  2. 48 CFR 227.7203-4 - License rights.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License rights. 227.7203-4..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-4 License rights. (a) Grant of license....

  3. 48 CFR 1952.227-77 - Rights in shop drawings.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Rights in shop drawings. 1952.227-77 Section 1952.227-77 Federal Acquisition Regulations System BROADCASTING BOARD OF GOVERNORS... Rights in shop drawings. As prescribed in 1927.405(h), insert the following clause: Rights in...

  4. 12 CFR 227.13 - Unfair credit contract provisions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Unfair credit contract provisions. 227.13... RESERVE SYSTEM UNFAIR OR DECEPTIVE ACTS OR PRACTICES (REGULATION AA) Credit Practices Rule § 227.13 Unfair credit contract provisions. It is an unfair act or practice for a bank to enter into a consumer...

  5. Research on Transport Properties of HFC-227ea

    Institute of Scientific and Technical Information of China (English)

    Lin Shi; Xiaojun Liu; Yuanyuan Duan; Lizhong Han; Mingshan Zhu

    2001-01-01

    HFC-227ea(1,1,1,2,3,3,3-heptafluoropropane) is considered as a promising refrigerant alternative, especially as a component in mixtures, to replace to CFC-12, HCFC-22 and R502. But reliable transport properties data for HFC-227ea are very limited. In this paper, experimental data of viscosity along the saturation line and gaseous thermal conductivity of HFC-227ea are given. The viscosity of HFC-227ea was measured with a capillary viscometer at temperatures between 263.15 K and 333.15 K along the saturation line and its uncertainty of the results is estimated to be no more than +3%. The thermal conductivity of gaseous HFC-227ea was also measured with a transient hot-wire instrument at temperatures between 259.28 K and 341.75 K and pressures up to 1.289MPa, and its uncertainty of the results is estimated to be less than +1%.

  6. Canadair CL-227 Remotely Piloted Vehicle

    Science.gov (United States)

    Clark, Andrew S.

    1983-08-01

    The Canadair CL-227 is a rotary winged Remotely Piloted Vehicle (RPV) intended initially as the air-vehicle for a medium range battlefield surveillance and target acquisition system. The concept on which this vehicle is based brings together in-house expertise as a designer and manufacturer of surveillance drones (AN-USD-50l -MIDGE-) with experience in rigid rotor technology from the CL-84 tilt wing VTOL program. The vehicle is essentially modular in design with a power module containing the engine, fuel and related systems, a rotor module containing the two counter-rotating rotors and control actuators, and a control module containing the autopilot, data link and sensor system. The vehicle is a true RPV (as opposed to a drone) as it is flown in real time by an operator on the ground and requires relatively little skill to pilot.

  7. 7 CFR 227.1 - General purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM General § 227.1 General purpose and scope. The purpose of these regulations is to implement section 19 of the Child Nutrition Act... child nutrition programs as a learning experience....

  8. 40 CFR 227.19 - Assessment of impact.

    Science.gov (United States)

    2010-07-01

    ... Dumping on Esthetic, Recreational and Economic Values § 227.19 Assessment of impact. An overall assessment... on the effect on esthetic, recreational and economic values based on the factors set forth in this... profitability of other commercial enterprises....

  9. 48 CFR 1352.227-70 - Rights in data, assignment of copyright.

    Science.gov (United States)

    2010-10-01

    ....227-70 Rights in data, assignment of copyright. As prescribed in 48 CFR 1327.404-4(a), insert the following clause: Rights in Data, Assignment of Copyright (APR 2010) In accordance with 48 CFR 52.227-17... of copyright. 1352.227-70 Section 1352.227-70 Federal Acquisition Regulations System DEPARTMENT...

  10. 48 CFR 252.227-7019 - Validation of asserted restrictions-Computer software.

    Science.gov (United States)

    2010-10-01

    ... restrictions-Computer software. 252.227-7019 Section 252.227-7019 Federal Acquisition Regulations System...—Computer software. As prescribed in 227.7104(e)(3) or 227.7203-6(c), use the following clause: Validation of Asserted Restrictions—Computer Software (JUN 1995) (a) Definitions. (1) As used in this...

  11. 7 CFR 227.35 - Responsibilities of State coordinator.

    Science.gov (United States)

    2010-01-01

    ... 227.35 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM State Coordinator... implementation of the State Plan, (f) Coordination of the Program with the Child Nutrition Programs at the...

  12. 22 CFR 227.200 - Agency and legislative liaison.

    Science.gov (United States)

    2010-04-01

    ... 227.200 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NEW RESTRICTIONS ON LOBBYING Activities... to an officer or employee of a person requesting or receiving a Federal contract, grant, loan, or cooperative agreement if the payment is for agency and legislative liaison activities not directly related...

  13. 22 CFR 227.110 - Certification and disclosure.

    Science.gov (United States)

    2010-04-01

    ...) Award of a Federal contract, grant, or cooperative agreement exceeding $100,000; or (2) An award of a... such person of: (1) A Federal contract, grant, or cooperative agreement exceeding $100,000; or (2) A... 227.110 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NEW RESTRICTIONS ON LOBBYING...

  14. 48 CFR 3452.227-72 - Advertising of awards.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Advertising of awards... Clauses 3452.227-72 Advertising of awards. As prescribed in 3427.472, insert the following clause in all solicitations and contracts other than purchase orders: Advertising of Awards (AUG 1987) The contractor...

  15. 49 CFR 227.113 - Noise operational controls.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating Employees. § 227.113 Noise operational controls. (a) Railroads may use noise operational controls at any sound level to reduce exposures to levels below those required by Table A-1 of appendix A...

  16. 49 CFR 227.107 - Hearing conservation program.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating Employees. § 227.107 Hearing conservation program. (a) Consistent with the requirements of the... exposure shall be computed in accordance with the tables in appendix A of this part, and without regard...

  17. 49 CFR 227.109 - Audiometric testing program.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating Employees. § 227.109 Audiometric testing program. (a) Each railroad shall establish and maintain... requirements found in 29 CFR 1910.95(h), the railroad must use that baseline audiogram. (iii) If the...

  18. 49 CFR 227.111 - Audiometric test requirements.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating Employees. § 227.111 Audiometric test requirements. (a) Audiometric tests shall be pure tone, air... with 5 U.S.C. 552(a) and 1 CFR part 51. You may obtain a copy of the incorporated standard from...

  19. 49 CFR 234.227 - Train detection apparatus.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY AND STATE ACTION PLANS Maintenance, Inspection, and Testing Maintenance Standards § 234.227 Train detection apparatus. (a) Train detection apparatus shall be maintained to detect a train or railcar in any part of a train detection circuit,...

  20. 48 CFR 227.7003 - Claims for copyright infringement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Claims for copyright... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Infringement Claims, Licenses, and Assignments 227.7003 Claims for copyright infringement. The procedures set...

  1. 7 CFR 227.31 - Audits, management reviews, and evaluations.

    Science.gov (United States)

    2010-01-01

    ... Section 227.31 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM State... institutions of higher education and public or private nonprofit educational or research agencies,...

  2. 7 CFR 227.4 - Application and agreement.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM General § 227.4 Application and... Program shall enter into a written agreement with the Department for the administration of the Program...

  3. 7 CFR 227.41 - Recovery of funds.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM Miscellaneous § 227.41 Recovery of... determines, through a review of the State agency's reports, program, or financial analysis, monitoring,...

  4. 40 CFR 227.30 - High-level radioactive waste.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false High-level radioactive waste. 227.30...-level radioactive waste. High-level radioactive waste means the aqueous waste resulting from the operation of the first cycle solvent extraction system, or equivalent, and the concentrated waste...

  5. 48 CFR 1952.227-76 - Government rights (unlimited).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Government rights... 1952.227-76 Government rights (unlimited). As prescribed in 1927.405(g), insert the following clause: Government Rights (Unlimited) (FEB 1985) The Government shall have unlimited rights, in all drawings,...

  6. 48 CFR 1852.227-84 - Patent rights clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Patent rights clauses. 1852... 1852.227-84 Patent rights clauses. The contracting officer shall insert the following provision as prescribed in 1827.303-70(e): Patent Rights Clauses (DEC 1989) This solicitation contains the patent...

  7. 30 CFR 227.301 - What are a State's responsibilities if it performs audits?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are a State's responsibilities if it performs audits? 227.301 Section 227.301 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Functions § 227.301 What are a State's responsibilities if it performs audits? If you perform audits...

  8. 48 CFR 227.7104 - Contracts under the Small Business Innovation Research (SBIR) Program.

    Science.gov (United States)

    2010-10-01

    ... Business Innovation Research (SBIR) Program. 227.7104 Section 227.7104 Federal Acquisition Regulations... Data and Computer Software—Small Business Innovation Research (SBIR) Program, when technical data or... PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7104 Contracts under the Small...

  9. 40 CFR 227.16 - Basis for determination of need for ocean dumping.

    Science.gov (United States)

    2010-07-01

    ... ocean dumping. 227.16 Section 227.16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CRITERIA FOR THE EVALUATION OF PERMIT APPLICATIONS FOR OCEAN DUMPING OF MATERIALS Need for Ocean Dumping § 227.16 Basis for determination of need for ocean dumping. (a) A need for...

  10. 40 CFR 227.27 - Limiting permissible con-cen-tra-tion (LPC).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Limiting permissible con-cen-tra-tion (LPC). 227.27 Section 227.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Definitions § 227.27 Limiting permissible con-cen-tra-tion (LPC). (a) The limiting permissible...

  11. 40 CFR 227.32 - Liquid, suspended particulate, and solid phases of a material.

    Science.gov (United States)

    2010-07-01

    ... MATERIALS Definitions § 227.32 Liquid, suspended particulate, and solid phases of a material. (a) For the... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Liquid, suspended particulate, and solid phases of a material. 227.32 Section 227.32 Protection of Environment ENVIRONMENTAL...

  12. 40 CFR 227.10 - Hazards to fishing, navigation, shorelines or beaches.

    Science.gov (United States)

    2010-07-01

    ..., shorelines or beaches. 227.10 Section 227.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Environmental Impact § 227.10 Hazards to fishing, navigation, shorelines or beaches. (a) Wastes which may... present a hazard to shorelines or beaches may be dumped only at sites and under conditions which...

  13. 48 CFR 52.227-2 - Notice and Assistance Regarding Patent and Copyright Infringement.

    Science.gov (United States)

    2010-10-01

    ... Regarding Patent and Copyright Infringement. 52.227-2 Section 52.227-2 Federal Acquisition Regulations... CLAUSES Text of Provisions and Clauses 52.227-2 Notice and Assistance Regarding Patent and Copyright... and Copyright Infringement (DEC 2007) (a) The Contractor shall report to the Contracting...

  14. 30 CFR 227.104 - What will MMS do when it receives a State's delegation proposal?

    Science.gov (United States)

    2010-07-01

    ... record the receipt date. MMS will notify you in writing within 15 business days whether your proposal is... delegation proposal? 227.104 Section 227.104 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT DELEGATION TO STATES Delegation Proposals § 227.104 What will MMS...

  15. 22 CFR Appendix B to Part 227 - Disclosure Form To Report Lobbying

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Disclosure Form To Report Lobbying B Appendix B to Part 227 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NEW RESTRICTIONS ON LOBBYING Pt. 227, App. B Appendix B to Part 227—Disclosure Form To Report Lobbying EC06OC91.012...

  16. 48 CFR 1852.227-86 - Commercial computer software-Licensing.

    Science.gov (United States)

    2010-10-01

    ... software-Licensing. 1852.227-86 Section 1852.227-86 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.227-86 Commercial computer software—Licensing. As prescribed in 1827.409-70, insert the following clause: Commercial Computer Software—Licensing (DEC 1987) (a) Any...

  17. 48 CFR 252.227-7027 - Deferred ordering of technical data or computer software.

    Science.gov (United States)

    2010-10-01

    ... technical data or computer software. 252.227-7027 Section 252.227-7027 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(b), use the following clause: Deferred Ordering of Technical Data or Computer Software (APR 1988) In addition to technical data or computer...

  18. 48 CFR 252.227-7026 - Deferred delivery of technical data or computer software.

    Science.gov (United States)

    2010-10-01

    ... technical data or computer software. 252.227-7026 Section 252.227-7026 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(a), use the following clause: Deferred Delivery of Technical Data or Computer Software (APR 1988) The Government shall have the right to require,...

  19. 30 CFR 227.110 - When and for how long are delegation agreements effective?

    Science.gov (United States)

    2010-07-01

    ... effective? 227.110 Section 227.110 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT DELEGATION TO STATES Delegation Process § 227.110 When and for how long are... Revenue Management as follows: (1) If you do not want to change the terms of your delegation agreement...

  20. 48 CFR 1852.227-14 - Rights in data-General.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Rights in data-General. 1852.227-14 Section 1852.227-14 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... 1852.227-14 Rights in data—General. As prescribed in 1827.409(a), add the following subparagraph (3)...

  1. 48 CFR 252.227-7039 - Patents-reporting of subject inventions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Patents-reporting of... CLAUSES Text of Provisions And Clauses 252.227-7039 Patents—reporting of subject inventions. As prescribed in 227.303(1), use the following clause: Patents—Reporting of Subject Inventions (APR 1990)...

  2. 48 CFR 252.227-7012 - Patent license and release contract.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Patent license and release... of Provisions And Clauses 252.227-7012 Patent license and release contract. As prescribed at 227.7012, insert the following clause in patent releases, license agreements, and assignments: (Contract...

  3. 42 CFR 435.227 - Individuals under age 21 who are under State adoption assistance agreements.

    Science.gov (United States)

    2010-10-01

    ... determines that— (i) At the time of the adoption placement, the child had special needs for medical or rehabilitative care that made the child difficult to place; and (ii) There is in effect an adoption assistance... adoption assistance agreements. 435.227 Section 435.227 Public Health CENTERS FOR MEDICARE &...

  4. 48 CFR 227.7204 - Contracts under the Small Business Innovative Research Program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracts under the Small Business Innovative Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovative Research Program. When contracting under the Small...

  5. 48 CFR 52.227-13 - Patent Rights-Ownership by the Government.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Patent Rights-Ownership by the Government. 52.227-13 Section 52.227-13 Federal Acquisition Regulations System FEDERAL ACQUISITION..., serial number and title, a copy of the patent application (including an English-language version if...

  6. 25 CFR 227.14 - Government reserves right to purchase oil and gas.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Government reserves right to purchase oil and gas. 227.14 Section 227.14 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING How to Acquire...

  7. 30 CFR 227.108 - How will MMS notify a State of its decision?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS notify a State of its decision? 227.108 Section 227.108 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... of its decision? MMS will notify you in writing of its decision on your delegation proposal. If...

  8. 48 CFR 52.227-15 - Representation of Limited Rights Data and Restricted Computer Software.

    Science.gov (United States)

    2010-10-01

    ... Rights Data and Restricted Computer Software. 52.227-15 Section 52.227-15 Federal Acquisition Regulations... Computer Software. As prescribed in 27.409(c), insert the following provision: Representation of Limited Rights Data and Restricted Computer Software (DEC 2007) (a) This solicitation sets forth the...

  9. 47 CFR 80.227 - Special requirements for protection from RF radiation.

    Science.gov (United States)

    2010-10-01

    ... requirements for protection from RF radiation. As part of the information provided with transmitters for ship... 47 Telecommunication 5 2010-10-01 2010-10-01 false Special requirements for protection from RF radiation. 80.227 Section 80.227 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY...

  10. 48 CFR 252.227-7014 - Rights in noncommercial computer software and noncommercial computer software documentation.

    Science.gov (United States)

    2010-10-01

    ... container and each page, or portions thereof, of printed material containing computer software for which... computer software and noncommercial computer software documentation. 252.227-7014 Section 252.227-7014... Rights in noncommercial computer software and noncommercial computer software documentation....

  11. 30 CFR 227.401 - What are a State's responsibilities if it processes production reports or royalty reports?

    Science.gov (United States)

    2010-07-01

    ... processes production reports or royalty reports? 227.401 Section 227.401 Mineral Resources MINERALS...' Responsibilities to Perform Delegated Functions § 227.401 What are a State's responsibilities if it processes production reports or royalty reports? In processing production reports or royalty reports you must:...

  12. 40 CFR 227.14 - Criteria for evaluating the need for ocean dumping and alternatives to ocean dumping.

    Science.gov (United States)

    2010-07-01

    ... ocean dumping and alternatives to ocean dumping. 227.14 Section 227.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CRITERIA FOR THE EVALUATION OF PERMIT APPLICATIONS FOR OCEAN DUMPING OF MATERIALS Need for Ocean Dumping § 227.14 Criteria for evaluating the need for...

  13. In vivo detection of prion amyloid plaques using [11C]BF-227 PET

    International Nuclear Information System (INIS)

    In vivo detection of pathological prion protein (PrP) in the brain is potentially useful for the diagnosis of transmissible spongiform encephalopathies (TSEs). However, there are no non-invasive ante-mortem means for detection of pathological PrP deposition in the brain. The purpose of this study is to evaluate the amyloid imaging tracer BF-227 with positron emission tomography (PET) for the non-invasive detection of PrP amyloid in the brain. The binding ability of BF-227 to PrP amyloid was investigated using autoradiography and fluorescence microscopy. Five patients with TSEs, including three patients with Gerstmann-Straeussler-Scheinker disease (GSS) and two patients with sporadic Creutzfeldt-Jakob disease (CJD), underwent [11C]BF-227 PET scans. Results were compared with data from 10 normal controls and 17 patients with Alzheimer's disease (AD). The regional to pons standardized uptake value ratio was calculated as an index of BF-227 retention. Binding of BF-227 to PrP plaques was confirmed using brain samples from autopsy-confirmed GSS cases. In clinical PET study, significantly higher retention of BF-227 was detected in the cerebellum, thalamus and lateral temporal cortex of GSS patients compared to that in the corresponding tissues of normal controls. GSS patients also showed higher retention of BF-227 in the cerebellum, thalamus and medial temporal cortex compared to AD patients. In contrast, the two CJD patients showed no obvious retention of BF-227 in the brain. Although [11C]BF-227 is a non-specific imaging marker of cerebral amyloidosis, it is useful for in vivo detection of PrP plaques in the human brain in GSS, based on the regional distribution of the tracer. PET amyloid imaging might provide a means for both early diagnosis and non-invasive disease monitoring of certain forms of TSEs. (orig.)

  14. In vivo detection of prion amyloid plaques using [{sup 11}C]BF-227 PET

    Energy Technology Data Exchange (ETDEWEB)

    Okamura, Nobuyuki; Yanai, Kazuhiko [Tohoku University School of Medicine, Department of Pharmacology, Sendai (Japan); Shiga, Yusei; Itoyama, Yasuhito [Tohoku University School of Medicine, Department of Neurology, Sendai (Japan); Furumoto, Shozo [Tohoku University School of Medicine, Department of Pharmacology, Sendai (Japan); Tohoku University, Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Sendai (Japan); Tashiro, Manabu [Tohoku University, Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Sendai (Japan); Tsuboi, Yoshio [Fukuoka University School of Medicine, Department of Neurology, Fukuoka (Japan); Furukawa, Katsutoshi; Arai, Hiroyuki [Institute of Development, Aging, and Cancer, Tohoku University, Department of Geriatrics and Gerontology, Division of Brain Sciences, Sendai (Japan); Iwata, Ren [Tohoku University, Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Sendai (Japan); Kudo, Yukitsuka [Tohoku University, Innovation of New Biomedical Engineering Center, Sendai (Japan); Doh-ura, Katsumi [Tohoku University School of Medicine, Department of Prion Research, 2-1 Seiryo-machi, Aoba-ku, Sendai (Japan)

    2010-05-15

    In vivo detection of pathological prion protein (PrP) in the brain is potentially useful for the diagnosis of transmissible spongiform encephalopathies (TSEs). However, there are no non-invasive ante-mortem means for detection of pathological PrP deposition in the brain. The purpose of this study is to evaluate the amyloid imaging tracer BF-227 with positron emission tomography (PET) for the non-invasive detection of PrP amyloid in the brain. The binding ability of BF-227 to PrP amyloid was investigated using autoradiography and fluorescence microscopy. Five patients with TSEs, including three patients with Gerstmann-Straeussler-Scheinker disease (GSS) and two patients with sporadic Creutzfeldt-Jakob disease (CJD), underwent [{sup 11}C]BF-227 PET scans. Results were compared with data from 10 normal controls and 17 patients with Alzheimer's disease (AD). The regional to pons standardized uptake value ratio was calculated as an index of BF-227 retention. Binding of BF-227 to PrP plaques was confirmed using brain samples from autopsy-confirmed GSS cases. In clinical PET study, significantly higher retention of BF-227 was detected in the cerebellum, thalamus and lateral temporal cortex of GSS patients compared to that in the corresponding tissues of normal controls. GSS patients also showed higher retention of BF-227 in the cerebellum, thalamus and medial temporal cortex compared to AD patients. In contrast, the two CJD patients showed no obvious retention of BF-227 in the brain. Although [{sup 11}C]BF-227 is a non-specific imaging marker of cerebral amyloidosis, it is useful for in vivo detection of PrP plaques in the human brain in GSS, based on the regional distribution of the tracer. PET amyloid imaging might provide a means for both early diagnosis and non-invasive disease monitoring of certain forms of TSEs. (orig.)

  15. Surgical intervention for advanced valvular heart disease in 227 cases

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xi; ZHONG Fo-tian; XU Zhe; XU Ying-qi; WANG Zhi-ping; WU Zhong-kai; TANG Bai-yun; XIONG Mai; YAO Jian-ping; SUN Pei-wu

    2005-01-01

    Background Although the results of surgical treatment in cardiac valve disease continue to improve, the postoperative mortality rate and the rate of complications in patients with advanced valvular heart disease (AVHD) are still very high. We did this retrospective study to summarize the surgical experience of heart valve replacement for patients with AVHD and discuss effective ways to improve the surgical outcome.Results The operative mortality rate was 13.2% (30/227). The main causes of death included multiple organ dysfunction syndrome (MODS), low cardiac output syndrome and ventricular fibrillation. From the results of the binary noncounterpart multivariate logistic regression, the following statistically significant factors were found to influence the operative mortality rate: redo operation, age ≥55 years, preoperative NYHA cardiac function grading, extracorporeal circulation time ≥120 minutes and postoperative usage of GIK (glucose, insulin and potassium) solution. All factors were risk ones except postoperative application of GIK. The Hosmer-Lemeshow goodness of fit coefficient of this model was 0.976.Conclusions The risk factors associated with postoperative mortality rate in the patients with AVHD were redo operation, age ≥55 years, preoperative NYHA cardiac function grading and extracorporeal circulation time ≥120 minutes. Postoperative usage of GIK acted as a kind of metabolic therapy and will improve the recovery for patients with AVHD. Active perioperative management and care will play a very important role in reducing the operative risk and improving the short term outcome of surgical treatment for the patients with AVHD.

  16. Development, integration and test of an automatic UAV recovery system for the CL227 VTOL-UAV

    OpenAIRE

    Μπώκος, Γιώργος Δ.; Ferrier, Bernard

    1995-01-01

    The CL227 autoland program was designed to operate at sea from small ship combatants. This article highlights the evolution of the automated ship recovery system being developed in support of the CL227 UAV. Test results are provided concentrating on system response and control aspects affecting the performance of the CL227 recovery activity. A brief summary of the feasibility and simulation studies is given. A description of the data link software and hardware components is presented.

  17. Extraction and purification of {sup 227}Ac and development of solid {sup 219}Rn source

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Quan; Qiu, Shoukang; Xiao, Detao; Zhou, Yaohui; An, Xiaogang [University of South China, Hengyang (China). Radon Key Laboratory of Hunan Province/School of Nuclear Science and Technology

    2014-04-01

    The method of {sup 227}Ac extraction and purification from high-grade uranium ore and the test results of solid {sup 219}Rn source made from {sup 227}Ac are reported in this paper. With five years of follow-up monitoring, radiochemical purity of {sup 227}Ac and the emanation power of solid {sup 219}Rn source has been checked by emanation method and γ-spectrometry, the results showed that {sup 228}Th, {sup 231}Pa and {sup 226}Ra have been effectively removed and the emanation power of {sup 219}Rn source is about 80%. The long-term test results also showed that the {sup 219}Rn emanation rate remains stable in a wide air humidity range (40% ∝ 90%). Though the {sup 219}Rn source has not been accurately calibrated yet, it has been applied in the research for delay coincidence measurement of {sup 223}Ra. (orig.)

  18. 25 CFR 900.227 - Can the awarding official change the decision after it has been made?

    Science.gov (United States)

    2010-04-01

    ... has been made? 900.227 Section 900.227 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... change the decision after it has been made? (a) The decision of the awarding official is final and... is timely commenced as authorized by the Contract Disputes Act. Once the decision has been made,...

  19. 48 CFR 252.227-7018 - Rights in noncommercial technical data and computer software-Small Business Innovation Research...

    Science.gov (United States)

    2010-10-01

    ... technical data and computer software-Small Business Innovation Research (SBIR) Program. 252.227-7018 Section... Innovation Research (SBIR) Program. As prescribed in 227.7104(a), use the following clause: Rights in Noncommercial Technical Data and Computer Software—Small Business Innovation Research (SBIR) Program (JUN...

  20. 48 CFR 227.7009 - Patent releases, license agreements, and assignments.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Patent releases, license... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Infringement Claims, Licenses, and Assignments 227.7009 Patent releases, license agreements,...

  1. 48 CFR 52.227-10 - Filing of Patent Applications-Classified Subject Matter.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Filing of Patent... Text of Provisions and Clauses 52.227-10 Filing of Patent Applications—Classified Subject Matter. As prescribed at 27.203-2, insert the following clause: Filing of Patent Applications—Classified Subject...

  2. 48 CFR 52.227-4 - Patent Indemnity-Construction Contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Patent Indemnity... Clauses 52.227-4 Patent Indemnity—Construction Contracts. As prescribed in 27.201-2(d)(1), insert the following clause: Patent Indemnity—Construction Contracts (DEC 2007) Except as otherwise provided,...

  3. 48 CFR 52.227-7 - Patents-Notice of Government Licensee.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Patents-Notice of... Clauses 52.227-7 Patents—Notice of Government Licensee. As prescribed at 27.202-5(b), insert the following provision: Patents—Notice of Government Licensee (APR 1984) The Government is obligated to pay a...

  4. Jesu, meine Freude BWV 227 van Johann Sebastian Bach : een praedicatio sonora

    NARCIS (Netherlands)

    Eikelboom, Arie

    2007-01-01

    In the oeuvre of Johann Sebastian Bach the motets take only a modest position. According to Bach's early biographers he must have written many motets, but only few have been preserved. Among these motets Jesu, meine Freude BWV 227 occupies a special position. It is the only one which combines a comp

  5. 25 CFR 227.25 - Inspection of premises, books and accounts.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises, books and accounts. 227.25... Inspection of premises, books and accounts. Lessee shall agree to allow the lessor and his agents or any... Department; and their books and records, showing manner of operations and persons interested, shall be...

  6. An ISO far-infrared survey of line and continuum emission for 227 galaxies

    Science.gov (United States)

    Brauher, J. R.

    2002-01-01

    Far-infrared line and continuum fluxes are presented for a sample of 227 galaxies observed with the Long Wavelength Spectrometer on the Infrared Space Observatory, selected from the ISO Data Archive and having an IRAS 60/100 mu m color ration of 0.2-1.4 and IRAS 60 mu m flux density between 0.1 Jy and 1300 Jy.

  7. 25 CFR 227.4 - Sale of oil and gas leases.

    Science.gov (United States)

    2010-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING How to Acquire Leases § 227.4 Sale of oil and... sales of oil and gas leases shall reserve to the Secretary of the Interior the right to reject all...

  8. The Political Discourse of the Campaign against Bilingual Education: From "Proposition 227" to "Horne v. Flores"

    Science.gov (United States)

    Yamagami, Mai

    2012-01-01

    Using the frameworks of critical discourse analysis, representation theory, and legitimization theory, this study examines the political discourse of the campaign for Proposition 227 in California--particularly, the key social representations of languages, their speakers, and the main political actors in the campaign. The analysis examines the…

  9. Has California's Passage of Proposition 227 Made a Difference in the Way We Teach?

    Science.gov (United States)

    Arellano-Houchin, Anna; Flamenco, Claudia; Merlos, Moises M.; Segura, Lorena

    2001-01-01

    Examined how teachers were impacted by California's Proposition 227, highlighting changes in teaching styles and beliefs about the proposition and its effectiveness. Teachers had to change their teaching strategies to accommodate the new curriculum. They were not sufficiently trained for immediate implementation of English-only education. Teaching…

  10. 48 CFR 1852.227-11 - Patent Rights-Retention by the Contractor (Short Form).

    Science.gov (United States)

    2010-10-01

    ... of tier, for experimental, developmental, research, design, or engineering work to be performed by... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Patent Rights-Retention by... CLAUSES Texts of Provisions and Clauses 1852.227-11 Patent Rights—Retention by the Contractor (Short...

  11. 30 CFR 227.102 - What royalty management functions will MMS not delegate?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What royalty management functions will MMS not... MINERALS REVENUE MANAGEMENT DELEGATION TO STATES Delegation of Mms Royalty Functions § 227.102 What royalty management functions will MMS not delegate? This section lists the principal royalty management...

  12. 30 CFR 227.101 - What royalty management functions may MMS delegate to a State?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What royalty management functions may MMS... THE INTERIOR MINERALS REVENUE MANAGEMENT DELEGATION TO STATES Delegation of Mms Royalty Functions § 227.101 What royalty management functions may MMS delegate to a State? (a) If there are oil and...

  13. 5 CFR 591.227 - What adjustment factors does OPM add to the price indexes?

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false What adjustment factors does OPM add to...-Nonforeign Areas Cost-Of-Living Allowances § 591.227 What adjustment factors does OPM add to the price indexes? OPM adds to the price index an adjustment factor that reflects differences in need, access to...

  14. Initial evaluation of {sup 227}Th-p-benzyl-DOTA-rituximab for low-dose rate {alpha}-particle radioimmunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Dahle, Jostein [Department of Radiation Biology, Rikshospitalet-Radiumhospitalet HE, Montebello, 0310 Oslo (Norway)]. E-mail: jostein.dahle@labmed.uio.no; Borrebaek, Jorgen [Algeta ASA, Kjelsasveien 172 A, 0411 Oslo (Norway); Melhus, Katrine B. [Department of Radiation Biology, Rikshospitalet-Radiumhospitalet HE, Montebello, 0310 Oslo (Norway); Bruland, Oyvind S. [Department of Clinical Medicine, University of Oslo, 0316 Oslo (Norway); Department of Oncology, Rikshospitalet-Radiumhospitalet HE, Montebello, 0310 Oslo (Norway); Salberg, Gro [Algeta ASA, Kjelsasveien 172 A, 0411 Oslo (Norway); Olsen, Dag Rune [Department of Radiation Biology, Rikshospitalet-Radiumhospitalet HE, Montebello, 0310 Oslo (Norway); Larsen, Roy H. [Algeta ASA, Kjelsasveien 172 A, 0411 Oslo (Norway)

    2006-02-15

    Radioimmunotherapy has proven clinically effective in patients with non-Hodgkin's lymphoma. Radioimmunotherapy trials have so far been performed with {beta}-emitting isotopes. In contrast to {beta}-emitters, the shorter range and high linear energy transfer (LET) of {alpha} particles allow for more efficient and selective killing of individually targeted tumor cells. However, there are several obstacles to the use of {alpha}-particle immunotherapy, including problems with chelation chemistry and nontarget tissue toxicity. The {alpha}-emitting radioimmunoconjugate {sup 227}Th-DOTA-p-benzyl-rituximab is a new potential anti-lymphoma agent that might overcome some of these difficulties. The present study explores the immunoreactivity, in vivo stability and biodistribution, as well as the effect on in vitro cell growth, of this novel radioimmunoconjugate. To evaluate in vivo stability, uptake in balb/c mice of the {alpha}-particle-emitting nuclide {sup 227}Th alone, the chelated form, {sup 227}Th-p-nitrobenzyl-DOTA and the radioimmunoconjugate {sup 227}Th-DOTA-p-benzyl-rituximab was compared in a range of organs at increasing time points after injection. The immunoreactive fraction of {sup 227}Th-DOTA-p-benzyl-rituximab was 56-65%. During the 28 days after injection of radioimmunoconjugate only, very modest amounts of the {sup 227}Th had detached from DOTA-p-benzyl-rituximab, indicating a relevant stability in vivo. The half-life of {sup 227}Th-DOTA-p-benzyl-rituximab in blood was 7.4 days. Incubation of lymphoma cells with {sup 227}Th-DOTA-p-benzyl-rituximab resulted in a significant antigen-dependent inhibition of cell growth. The data presented here warrant further studies of {sup 227}Th-DOTA-p-benzyl-rituximab.

  15. Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy

    International Nuclear Information System (INIS)

    Radioimmunotherapy has proven clinically effective in patients with non-Hodgkin's lymphoma. Radioimmunotherapy trials have so far been performed with β-emitting isotopes. In contrast to β-emitters, the shorter range and high linear energy transfer (LET) of α particles allow for more efficient and selective killing of individually targeted tumor cells. However, there are several obstacles to the use of α-particle immunotherapy, including problems with chelation chemistry and nontarget tissue toxicity. The α-emitting radioimmunoconjugate 227Th-DOTA-p-benzyl-rituximab is a new potential anti-lymphoma agent that might overcome some of these difficulties. The present study explores the immunoreactivity, in vivo stability and biodistribution, as well as the effect on in vitro cell growth, of this novel radioimmunoconjugate. To evaluate in vivo stability, uptake in balb/c mice of the α-particle-emitting nuclide 227Th alone, the chelated form, 227Th-p-nitrobenzyl-DOTA and the radioimmunoconjugate 227Th-DOTA-p-benzyl-rituximab was compared in a range of organs at increasing time points after injection. The immunoreactive fraction of 227Th-DOTA-p-benzyl-rituximab was 56-65%. During the 28 days after injection of radioimmunoconjugate only, very modest amounts of the 227Th had detached from DOTA-p-benzyl-rituximab, indicating a relevant stability in vivo. The half-life of 227Th-DOTA-p-benzyl-rituximab in blood was 7.4 days. Incubation of lymphoma cells with 227Th-DOTA-p-benzyl-rituximab resulted in a significant antigen-dependent inhibition of cell growth. The data presented here warrant further studies of 227Th-DOTA-p-benzyl-rituximab

  16. DIRECT LIQUEFACTION PROOF-OF-CONCEPT PROGRAM - BENCH RUN PB-10 (HTI 227-109)

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1999-12-30

    This report presents the results of the bench-scale test, PB-10, performed at HTI's facilities under DOE contract (HTI Run No. 227-109). This bench test continues the work that was started in PDU testing 260-007. Previous bench test (PB-09, HTI 227-106) was performed on different seams of Chinese coal (Shenhua Ningtiaota Coal No.2 and No.3). Since another coal, Shangwan coal was selected for the liquefaction plant, PB-10 was made as approved by DOE/COR. The objective of this test was to evaluate the liquefaction performance of Shangwan coal utilizing various backend processing and recycle schemes. Additionally, this test was to collect available process data to allow for the best scale-up process design possible from this particular unit.

  17. Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.

    Directory of Open Access Journals (Sweden)

    Roberta d'Emmanuele di Villa Bianca

    Full Text Available Urothelium, the epithelial lining the inner surface of human bladder, plays a key role in bladder physiology and pathology. It responds to chemical, mechanical and thermal stimuli by releasing several factors and mediators. Recently it has been shown that hydrogen sulfide contributes to human bladder homeostasis. Hydrogen sulfide is mainly produced in human bladder by the action of cystathionine-β-synthase. Here, we demonstrate that human cystathionine-β-synthase activity is regulated in a cGMP/PKG-dependent manner through phosphorylation at serine 227. Incubation of human urothelium or T24 cell line with 8-Bromo-cyclic-guanosine monophosphate (8-Br-cGMP but not dibutyryl-cyclic-adenosine monophosphate (d-cAMP causes an increase in hydrogen sulfide production. This result is congruous with the finding that PKG is robustly expressed but PKA only weakly present in human urothelium as well as in T24 cells. The cGMP/PKG-dependent phosphorylation elicited by 8-Br-cGMP is selectively reverted by KT5823, a specific PKG inhibitor. Moreover, the silencing of cystathionine-β-synthase in T24 cells leads to a marked decrease in hydrogen sulfide production either in basal condition or following 8-Br-cGMP challenge. In order to identify the phosphorylation site, recombinant mutant proteins of cystathionine-β-synthase in which Ser32, Ser227 or Ser525 was mutated in Ala were generated. The Ser227Ala mutant cystathionine-β-synthase shows a notable reduction in basal biosynthesis of hydrogen sulfide becoming unresponsive to the 8-Br-cGMP challenge. A specific antibody that recognizes the phosphorylated form of cystathionine-β-synthase has been produced and validated by using T24 cells and human urothelium. In conclusion, human cystathionine-β-synthase can be phosphorylated in a PKG-dependent manner at Ser227 leading to an increased catalytic activity.

  18. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Science.gov (United States)

    Dubey, R.; Sugathan, P.; Jhingan, A.; Kaur, Gurpreet; Mukul, Ish; Mohanto, G.; Siwal, D.; Saneesh, N.; Banerjee, T.; Thakur, Meenu; Mahajan, Ruchi; Kumar, N.; Chatterjee, M. B.

    2016-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30-50 MeV.

  19. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Directory of Open Access Journals (Sweden)

    R. Dubey

    2016-01-01

    Full Text Available Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F+206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30–50 MeV.

  20. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    CERN Document Server

    Dubey, R; Jhingan, A; Kaur, Gurpreet; Mukul, Ish; Mohanto, G; Siwal, D; Saneesh, N; Banerjee, T; Thakur, Meenu; Mahajan, Ruchi; Kumar, N; Chatterjee, M B

    2015-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206, 208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224, 226Th and 228U around barrier energies. Enhancement in mass variance of 225, 227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224, 226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential energy surfaces at low excitation energ...

  1. In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227-DOTA-Rituximab

    International Nuclear Information System (INIS)

    Purpose: To determine whether the low-dose-rate α-particle-emitting radioimmunoconjugate 227Th-1,4,7,10-p-isothiocyanato-benzyl-tetraazacyclododecane-1,4,7, 10-tetraacetic acid (DOTA)-rituximab can be used to inactivate lymphoma cells growing as single cells and small colonies. Methods and Materials: CD20-positive lymphoma cell lines were treated with 227Th-DOTA-rituximab for 1-5 weeks. To simulate the in vivo situation with continuous but decreasing supply of radioimmunoconjugates from the blood pool, the cells were not washed after incubation with 227Th-DOTA-rituximab, but half of the medium was replaced with fresh medium, and cell concentration and cell-bound activity were determined every other day after start of incubation. A microdosimetric model was established to estimate the average number of hits in the nucleus for different localizations of activity. Results: There was a specific targeted effect on cell growth of the 227Th-DOTA-rituximab treatment. Although the cells were not washed after incubation with 227Th-DOTA-rituximab, the average contribution of activity in the medium to the mean dose was only 6%, whereas the average contribution from activity on the cells' own surface was 78%. The mean dose rates after incubation with 800 Bq/mL 227Th-DOTA-rituximab varied from 0.01 to 0.03 cGy/min. The average delay in growing from 105 to 107 cells/mL was 15 days when the cells were treated with a mean absorbed radiation dose of 2 Gy α-particle radiation from 227Th-DOTA-rituximab, whereas it was 11 days when the cells were irradiated with 6 Gy of X-radiation. The relative biologic effect of the treatment was estimated to be 2.9-3.4. Conclusions: The low-dose-rate radioimmunoconjugate 227Th-DOTA-rituximab is suitable for inactivation of single lymphoma cells and small colonies of lymphoma cells.

  2. 27 CFR 28.227 - Removals of beer by persons other than the brewer or agent of the brewer.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removals of beer by... ALCOHOL Exportation of Beer With Benefit of Drawback Execution of Claims § 28.227 Removals of beer by persons other than the brewer or agent of the brewer. Where there is a removal of taxpaid beer by a...

  3. 48 CFR 227.7107-1 - Architectural designs and data clauses for architect-engineer or construction contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Architectural designs and... construction involving architect-engineer services, is to obtain a unique architectural design of a building, a... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7107-1...

  4. Complete genome sequence of Lactobacillus plantarum LZ227, a potential probiotic strain producing B-group vitamins.

    Science.gov (United States)

    Li, Ping; Zhou, Qingqing; Gu, Qing

    2016-09-20

    B-group vitamins play an important role in human metabolism, whose deficiencies are associated with a variety of disorders and diseases. Certain microorganisms such as Lactic acid bacteria (LAB) have been shown to have capacities for B-group vitamin production and thus could potentially replace chemically synthesized vitamins for food fortification. A potential probiotic strain named Lactobacillus plantarum LZ227, which was isolated from raw cow milk in this study, exhibits the ability to produce B-group vitamins. Complete genome sequencing of LZ227 was performed to gain insights into the genetic elements involved in B-group vitamin production. The genome of LZ227 contains a circular 3,131,750-bp chromosome, three circular plasmids and two predicted linear plasmids. LZ227 also contains gene clusters for biosynthesis of both riboflavin and folate. This genome sequence provides a basis for further elucidation of its molecular genetics and probiotic functions, and will facilitate its applications as starter cultures in food industry. PMID:27480344

  5. Complete genome sequence of Lactobacillus plantarum LZ227, a potential probiotic strain producing B-group vitamins.

    Science.gov (United States)

    Li, Ping; Zhou, Qingqing; Gu, Qing

    2016-09-20

    B-group vitamins play an important role in human metabolism, whose deficiencies are associated with a variety of disorders and diseases. Certain microorganisms such as Lactic acid bacteria (LAB) have been shown to have capacities for B-group vitamin production and thus could potentially replace chemically synthesized vitamins for food fortification. A potential probiotic strain named Lactobacillus plantarum LZ227, which was isolated from raw cow milk in this study, exhibits the ability to produce B-group vitamins. Complete genome sequencing of LZ227 was performed to gain insights into the genetic elements involved in B-group vitamin production. The genome of LZ227 contains a circular 3,131,750-bp chromosome, three circular plasmids and two predicted linear plasmids. LZ227 also contains gene clusters for biosynthesis of both riboflavin and folate. This genome sequence provides a basis for further elucidation of its molecular genetics and probiotic functions, and will facilitate its applications as starter cultures in food industry.

  6. 78 FR 9420 - Central Gulf of Mexico Planning Area (CPA) Outer Continental Shelf (OCS) Oil and Gas Lease Sale 227

    Science.gov (United States)

    2013-02-08

    ... 227 will begin at 9 a.m., Wednesday, March 20, 2013, at the Mercedes-Benz Superdome, 1500 Sugarbowl... to 66 FR 28002 (published May 21, 2001), 69 FR 23211 (published April 28, 2004), 72 FR 27590 (published May 16, 2007), 72 FR 35720 (published June 29, 2007), 73 FR 63505 (published October 24,...

  7. Accelerating growth of HFC-227ea (1,1,1,2,3,3,3-heptafluoropropane) in the atmosphere

    NARCIS (Netherlands)

    Laube, J.C.; Martinerie, P.; Witrant, E.; Brenninkmeijer, C.A.M.; Bolder, M.; Rockmann, T.; van der Veen, C; Sturges, W.T.

    2010-01-01

    We report the first measurements of 1,1,1,2,3,3,3-heptafluoropropane (HFC-227ea), a substitute for ozone depleting compounds, in air samples originating from remote regions of the atmosphere and present evidence for its accelerating growth. Observed mixing ratios ranged from below 0.01 ppt in deep f

  8. Analysis of drug resistance for 227 strains enterococci%227株肠球菌细菌耐药性分析

    Institute of Scientific and Technical Information of China (English)

    李怀先; 黄素荣

    2012-01-01

    Objective To study the enterococcal distribution in clinical samples and their drug resistance to commonly use antibiotic and provide the guidance for rational administration. Methods Adopting paper diffusion method to observe the drug resistance of enterococci isolated from clinical samples in our hospital and analyzing their distribution in the samples. Results En-terococcus faecalis accounts for 44. 1 % in 227 strains and Enterococcus faeciura accounts for 37. 9% , the other kinds of enterococci were rare. There was no statistical difference between drug resistance of Enterococcus faecium and that of enterococcus faecalis. Vancomycin was the most potent antimicrobial. Penicillin,ampicillin,and nitrofurantion showed good antibacterial activity against enterococcus faecalis. Enterococcus faecium displayed high-level resistance against antibiotics in addition to glycopeptides. Conclusion Doctor should pay attention to the drug resistance about clinically common pathogenic bacterium. Continual surveillance of resistance rate of enterococcus is important to direct the treatment of enterococcus infections.%目的 了解肠球菌在临床标本中的分布及对常用的抗菌药物的耐药现状,指导临床合理用药.方法 对临床标本中分离出的细菌进行系统检验,采用纸片法对分离鉴定后的肠球菌进行药物敏感性试验.结果 肠球菌可在临床常见的多种标本中检出,粪肠球菌(44.1%)与屎肠球菌(37.9%)常见,其他肠球菌(18%)少见.对常用抗菌药物的耐药性,粪肠球菌和屎肠球菌之间的差异无统计学意义.万古霉素是敏感性最高的抗生素.青霉素、氨苄西林和呋喃妥因对粪肠球菌具有较好的抗菌活性.屎肠球菌对除糖肽类抗生素以外的所有临床常用抗菌药物显示高水平耐药.结论 临床医生应关注临床常见病原菌的耐药性研究,动态监测肠球菌的耐药状况对指导临床治疗具有重要意义.

  9. Interannual variation of the quasi-two-day wave at 22.7 S

    Science.gov (United States)

    Lima, Lourivaldo; Jacobi, Christoph; Batista, Paulo; Rodrigues de Araujo, Luciana; Rodrigues, Chayenny E. S.; Lilienthal, Friederike

    2016-07-01

    In the present investigation, the mesosphere/lower thermosphere winds at Cachoeira Paulista (22.7° S, 45.0° W) obtained by a VHF all sky interferometric meteor radar have been used to investigate the interannual variability of the quasi-two-day wave (QTDW) amplitudes at a low latitude in the Southern Hemisphere. The wind data were obtained from December 1999 to July 2006, from September 2007 to October 2008 and from December 2013 to April 2015. The analysis shows that meridional amplitudes for QTDW are larger than zonal amplitudes and the strongest amplitudes occur after austral summer solstice in January-February. Besides semiannual and annual oscillations, the QTDW amplitudes in the meridional winds also show weak quasi-biennial oscillation (QBO). The summer QTDW in the meridional winds also shows a possible correlation with solar activity. The amplitudes are nearly in phase with the 11 year solar cycle, and the solar maxima leads the QTDW maxima by one year. Finally, larger QTDW amplifications have been observed during 2003, 2004, 2006 and 2015 summers. The unusual major sudden stratospheric warming (SSW) event suggests a coupling between QTDW amplification and SSW during Jan-Feb 2006. The mechanistic global circulation model MUAM of the middle and upper atmosphere has been used to simulate the dynamic configuration during January major and minor SSW events.

  10. Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease

    Institute of Scientific and Technical Information of China (English)

    李深; 饶向荣; 王素霞; 张改华; 李晓玫; 戴希文; 陈可冀

    2009-01-01

    To investigate the relationship between the severity of Chinese medicine(CM) bloodstasis syndrome(BSS) with clinical features and renal lesion indexes of the primary glomerular disease. Methods:An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases,and their severity of BSS were scored three days before renal biopsies were performed.The following clinical indexes were analyzed:age,course of glomerular diseases,24-h urine protein ration...

  11. Interaction between supernova remnant G22.7–0.2 and the ambient molecular clouds

    Energy Technology Data Exchange (ETDEWEB)

    Su, Yang; Yang, Ji; Zhou, Xin [Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Zhou, Ping; Chen, Yang [Department of Astronomy, Nanjing University, 163 Xianlin Avenue, Nanjing 210093 (China)

    2014-12-01

    We have carried out {sup 12}CO (J = 1-0 and 2-1), {sup 13}CO (J = 1-0), and C{sup 18}O (J = 1-0) observations in the direction of the supernova remnant (SNR) G22.7–0.2. A filamentary molecular gas structure, which is likely part of a larger molecular complex with V {sub LSR} ∼ 75-79 km s{sup –1}, is detected and is found to surround the southern boundary of the remnant. In particular, the high-velocity wing (77-110 km s{sup –1}) in the {sup 12}CO (J = 1-0 and J = 2-1) emission shows convincing evidence of the interaction between SNR G22.7–0.2 and the 75-79 km s{sup –1} molecular clouds (MCs). Spectra with redshifted profiles, a signature of shocked molecular gas, are seen in the southeastern boundary of the remnant. The association between the remnant and the 77 km s{sup –1} MCs places the remnant at the near distance of 4.4 ± 0.4 kpc, which agrees with a location on the Scutum-Crux arm. We suggest that SNR G22.7–0.2, SNR W41, and H II region G022.760-0.485 are at the same distance and are associated with GMC G23.0–0.4.

  12. Interaction between supernova remnant G22.7–0.2 and the ambient molecular clouds

    International Nuclear Information System (INIS)

    We have carried out 12CO (J = 1-0 and 2-1), 13CO (J = 1-0), and C18O (J = 1-0) observations in the direction of the supernova remnant (SNR) G22.7–0.2. A filamentary molecular gas structure, which is likely part of a larger molecular complex with V LSR ∼ 75-79 km s–1, is detected and is found to surround the southern boundary of the remnant. In particular, the high-velocity wing (77-110 km s–1) in the 12CO (J = 1-0 and J = 2-1) emission shows convincing evidence of the interaction between SNR G22.7–0.2 and the 75-79 km s–1 molecular clouds (MCs). Spectra with redshifted profiles, a signature of shocked molecular gas, are seen in the southeastern boundary of the remnant. The association between the remnant and the 77 km s–1 MCs places the remnant at the near distance of 4.4 ± 0.4 kpc, which agrees with a location on the Scutum-Crux arm. We suggest that SNR G22.7–0.2, SNR W41, and H II region G022.760-0.485 are at the same distance and are associated with GMC G23.0–0.4.

  13. Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation.

    Science.gov (United States)

    Liu, Weizhi; Jankowska-Anyszka, Marzena; Piecyk, Karolina; Dickson, Laura; Wallace, Adam; Niedzwiecka, Anna; Stepinski, Janusz; Stolarski, Ryszard; Darzynkiewicz, Edward; Kieft, Jeffrey; Zhao, Rui; Jones, David N M; Davis, Richard E

    2011-11-01

    Metazoan spliced leader (SL) trans-splicing generates mRNAs with an m(2,2,7)G-cap and a common downstream SL RNA sequence. The mechanism for eIF4E binding an m²²⁷G-cap is unknown. Here, we describe the first structure of an eIF4E with an m(2,2,7)G-cap and compare it to the cognate m⁷G-eIF4E complex. These structures and Nuclear Magnetic Resonance (NMR) data indicate that the nematode Ascaris suum eIF4E binds the two different caps in a similar manner except for the loss of a single hydrogen bond on binding the m(2,2,7)G-cap. Nematode and mammalian eIF4E both have a low affinity for m(2,2,7)G-cap compared with the m⁷G-cap. Nematode eIF4E binding to the m⁷G-cap, m(2,2,7)G-cap and the m(2,2,7)G-SL 22-nt RNA leads to distinct eIF4E conformational changes. Additional interactions occur between Ascaris eIF4E and the SL on binding the m(2,2,7)G-SL. We propose interactions between Ascaris eIF4E and the SL impact eIF4G and contribute to translation initiation, whereas these interactions do not occur when only the m(2,2,7)G-cap is present. These data have implications for the contribution of 5'-UTRs in mRNA translation and the function of different eIF4E isoforms. PMID:21965542

  14. The HB22.7-vcMMAE antibody-drug conjugate has efficacy against non-Hodgkin lymphoma mouse xenografts with minimal systemic toxicity.

    Science.gov (United States)

    Abuhay, Mastewal; Kato, Jason; Tuscano, Emily; Barisone, Gustavo A; Sidhu, Ranjit S; O'Donnell, Robert T; Tuscano, Joseph M

    2016-10-01

    In this study, HB22.7, an anti-CD22 monoclonal antibody, was used for specific, targeted delivery of monomethyl auristatin E (MMAE) to non-Hodgkin lymphoma (NHL). MMAE was covalently coupled to HB22.7 through a valine-citrulline peptide linker (vc). Maleimide-functionalized vcMMAE (mal-vcMMAE) was reacted with thiols of the partially reduced mAb. Approximately 4 molecules of MMAE were conjugated to HB22.7 as determined by residual thiol measurement and hydrophobic interaction chromatography-HPLC (HIC-HPLC). HB22.7-vcMMAE antibody-drug conjugate (ADC) retained its binding to Ramos NHL cells and also exhibited potent and specific in vitro cytotoxicity on a panel of B cell NHL cell lines with IC50s of 20-284 ng/ml. HB22.7-vcMMAE also showed potent efficacy in vivo against established NHL xenografts using the DoHH2 and Granta 519 cell lines. One dose of the ADC induced complete and persistent response in all DoHH2 xenografts and 90 % of Granta xenografts. Minimal toxicity was observed. In summary, HB22.7-vcMMAE is an effective ADC that should be evaluated for clinical translation. PMID:27506529

  15. Outcomes From AAS Hack Day at the 227th AAS Meeting

    Science.gov (United States)

    Kohler, Susanna

    2016-01-01

    Editors Note:This is a final post from the 227th AAS Meeting in Kissimmee, FL. This special summary of AAS Hack Day, a meeting of AAS members to collaboratively work on various small projects, was written by Meredith Rawls (@Merrdiff) and was originally posted on astrobites.com.As the 227thAmerican Astronomical Society meeting drew to a close (see highlights from Day 1, Day 2, Day 3, and Day 4), a group of at least 50 attendees spent Day 4working on small projects fondly called hacks. Thanks to sponsorship from LSST and Northrup Grumman, the industrious hackers werewell-caffeinated and fed so we could devote time and energy toworking in groups on one-day projects.TheHack Day beganat 10am with pitches. Anybody with a project idea was welcome to briefly speak and try to convince others to work with them. Only someideas panned out, but the enthusiasm was palpable. Its not every day you get a full room of astronomers and affiliates eager to spend hours working on fun and useful projects to benefit the community.#hackAAS is getting underway! #aas227 pic.twitter.com/yX7jlOnSCK James R A Davenport (@jradavenport) January 8, 2016Here is a rundown of what we accomplished. Pretty impressive for a single day! Many thanks to fellow astrobiter Erika Nesvold (now at Carnegie DTM; @erikanesvold) whose hack was live-documenting all the other hacks. Her tweets as @astrobites appeared with the #hackaas hashtag, and her notes made this recap post infinitely easier to write.Interested in joining the fun? Sign up for Hack Day at the 2017 JanuaryAAS meeting (its free with meeting registration), and consider applying for the .Astronomy conference this summer.Towards Optimal Session Scheduling:Adrian Price-Whelan (Columbia), David Hogg (NYU), and Scott Idem (AAS) began writing a program to take all submitted abstracts to a conference like AAS and sort them using keywords to avoid scheduling similar talks in parallel sessions. Its impossible to make everyone happy, but minimizing conflicts

  16. The HB22.7 Anti-CD22 monoclonal antibody enhances bortezomib-mediated lymphomacidal activity in a sequence dependent manner

    Directory of Open Access Journals (Sweden)

    Martin Shiloh M

    2011-12-01

    Full Text Available Abstract Most non-Hodgkin's lymphomas (NHL initially respond to chemotherapy, but relapse is common and treatment is often limited by chemotherapy-related toxicity. Bortezomib, is a highly selective proteasome inhibitor with anti-NHL activity; it is currently FDA approved for second-line treatment of mantle cell lymphoma (MCL. Bortezomib exerts its activity in part through the generation of reactive oxygen species (ROS and also by the induction of apoptosis. We previously validated CD22 as a potential target in treating NHL and have shown that the anti-CD22 ligand blocking antibody, HB22.7, has significant independent lymphomacidal properties in NHL xenograft models. We sought to determine whether or not these agents would work synergistically to enhance cytotoxicity. Our results indicate that treatment of NHL cell lines with HB22.7 six hours prior to bortezomib significantly diminished cell viability. These effects were not seen when the agents were administered alone or when bortezomib was administered prior to HB22.7. Additionally, HB22.7 treatment prior to bortezomib increased apoptosis in part through enhanced ROS generation. Finally, in a mouse xenograft model, administration of HB22.7 followed 24 hours later by bortezomib resulted in 23% smaller tumor volumes and 20% enhanced survival compared to treatment with the reverse sequence. Despite the increased efficacy of HB22.7 treatment followed by bortezomib, there was no corresponding decrease in peripheral blood cell counts, indicating no increase in toxicity. Our results suggest that pre-treatment with HB22.7 increases bortezomib cytotoxicity, in part through increased reactive oxygen species and apoptosis, and that this sequential treatment combination has robust efficacy in vivo.

  17. Combined renin inhibition/(prorenin receptor blockade in diabetic retinopathy--a study in transgenic (mREN227 rats.

    Directory of Open Access Journals (Sweden)

    Wendy W Batenburg

    Full Text Available Dysfunction of renin-angiotensin system (RAS contributes to the pathogenesis of diabetic retinopathy (DR. Prorenin, the precursor of renin is highly elevated in ocular fluid of diabetic patients with proliferative retinopathy. Prorenin may exert local effects in the eye by binding to the so-called (prorenin receptor ((PRR. Here we investigated the combined effects of the renin inhibitor aliskiren and the putative (PRR blocker handle-region peptide (HRP on diabetic retinopathy in streptozotocin (STZ-induced diabetic transgenic (mRen227 rats (a model with high plasma prorenin levels as well as prorenin stimulated cytokine expression in cultured Müller cells. Adult (mRen227 rats were randomly divided into the following groups: (1 non-diabetic; (2 diabetic treated with vehicle; (3 diabetic treated with aliskiren (10 mg/kg per day; and (4 diabetic treated with aliskiren+HRP (1 mg/kg per day. Age-matched non-diabetic wildtype Sprague-Dawley rats were used as control. Drugs were administered by osmotic minipumps for three weeks. Transgenic (mRen227 rat retinas showed increased apoptotic cell death of both inner retinal neurons and photoreceptors, increased loss of capillaries, as well as increased expression of inflammatory cytokines. These pathological changes were further exacerbated by diabetes. Aliskiren treatment of diabetic (mRen227 rats prevented retinal gliosis, and reduced retinal apoptotic cell death, acellular capillaries and the expression of inflammatory cytokines. HRP on top of aliskiren did not provide additional protection. In cultured Müller cells, prorenin significantly increased the expression levels of IL-1α and TNF-α, and this was completely blocked by aliskiren or HRP, their combination, (PRR siRNA and the AT1R blocker losartan, suggesting that these effects entirely depended on Ang II generation by (PRR-bound prorenin. In conclusion, the lack of effect of HRP on top of aliskiren, and the Ang II-dependency of the ocular

  18. Eta' photoproduction on the proton for photon energies from 1.527 to 2.227 GeV.

    Science.gov (United States)

    Dugger, M; Ball, J P; Collins, P; Pasyuk, E; Ritchie, B G; Adams, G; Ambrozewicz, P; Anciant, E; Anghinolfi, M; Asavapibhop, B; Asryan, G; Audit, G; Avakian, H; Bagdasaryan, H; Baillie, N; Baltzell, N A; Barrow, S; Batourine, V; Battaglieri, M; Beard, K; Bedlinskiy, I; Bektasoglu, M; Bellis, M; Benmouna, N; Berman, B L; Bianchi, N; Biselli, A S; Bonner, B E; Bouchigny, S; Boiarinov, S; Bradford, R; Branford, D; Briscoe, W J; Brooks, W K; Bültmann, S; Burkert, V D; Butuceanu, C; Calarco, J R; Careccia, S L; Carman, D S; Carnahan, B; Chen, S; Cole, P L; Coleman, A; Coltharp, P; Cords, D; Corvisiero, P; Crabb, D; Crannell, H; Credé, V; Cummings, J P; De Sanctis, E; DeVita, R; Degtyarenko, P V; Denizli, H; Dennis, L; Deur, A; Dharmawardane, K V; Dhuga, K S; Djalali, C; Dodge, G E; Donnelly, J; Doughty, D; Dragovitsch, P; Dytman, S; Dzyubak, O P; Egiyan, H; Egiyan, K S; Elouadrhiri, L; Empl, A; Eugenio, P; Fatemi, R; Fedotov, G; Feldman, G; Feuerbach, R J; Forest, T A; Funsten, H; Garçon, M; Gavalian, G; Gilfoyle, G P; Giovanetti, K L; Girod, F X; Goetz, J T; Gothe, R W; Griffioen, K A; Guidal, M; Guillo, M; Guler, N; Guo, L; Gyurjyan, V; Hadjidakis, C; Hakobyan, R S; Hardie, J; Heddle, D; Hersman, F W; Hicks, K; Hleiqawi, I; Holtrop, M; Hu, J; Huertas, M; Hyde-Wright, C E; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Ito, M M; Jenkins, D; Jo, H S; Joo, K; Juengst, H G; Kellie, J D; Khandaker, M; Kim, K Y; Kim, K; Kim, W; Klein, A; Klein, F J; Klimenko, A V; Klusman, M; Kossov, M; Kramer, L H; Kubarovsky, V; Kuhn, J; Kuhn, S E; Lachniet, J; Laget, J M; Langheinrich, J; Lawrence, D; Lee, T; Lima, A C S; Livingston, K; Lukashin, K; Manak, J J; Marchand, C; Maximon, L C; McAleer, S; McKinnon, B; McNabb, J W C; Mecking, B A; Mestayer, M D; Meyer, C A; Mibe, T; Mikhailov, K; Minehart, R; Mirazita, M; Miskimen, R; Mokeev, V; Morrow, S A; Muccifora, V; Mueller, J; Mutchler, G S; Nadel-Turonski, P; Napolitano, J; Nasseripour, R; Niccolai, S; Niculescu, G; Niczyporuk, B B; Niyazov, R A; Nozar, M; O'Rielly, G V; Osipenko, M; Ostrovidov, A I; Park, K; Paterson, C; Philips, S A; Pierce, J; Pivnyuk, N; Pocanic, D; Pogorelko, O; Pozdniakov, S; Preedom, B M; Price, J W; Prok, Y; Protopopescu, D; Qin, L M; Raue, B A; Riccardi, G; Ricco, G; Ripani, M; Ronchetti, F; Rosner, G; Rossi, P; Rowntree, D; Rubin, P D; Sabatié, F; Salgado, C; Santoro, J P; Sapunenko, V; Schumacher, R A; Serov, V S; Shafi, A; Sharabian, Y G; Shaw, J; Simionatto, S; Skabelin, A V; Smith, E S; Smith, L C; Sober, D I; Spraker, M; Stavinsky, A; Stepanyan, S S; Stepanyan, S; Stokes, B E; Stoler, P; Strakovsky, I I; Strauch, S; Taiuti, M; Taylor, S; Tedeschi, D J; Thoma, U; Thompson, R; Tkabladze, A; Tkachenko, S; Tur, C; Ungaro, M; Vineyard, M F; Vlassov, A V; Wang, K; Weinstein, L B; Weller, H; Weygand, D P; Williams, M; Wolin, E; Wood, M H; Yegneswaran, A; Yun, J; Zana, L; Zhang, J

    2006-02-17

    Differential cross sections for the reaction gamma p --> eta' p have been measured with the CLAS spectrometer and a tagged photon beam with energies from 1.527 to 2.227 GeV. The results reported here possess much greater accuracy than previous measurements. Analyses of these data suggest for the first time the coupling of the eta'N channel to both the S11(1535) and P11(1710) resonances, known to couple strongly to the etaN channel in photoproduction on the proton, and the importance of J = 3/2 resonances in the process. PMID:16605984

  19. Standardized, systemic phenotypic analysis of Umod(C93F and Umod(A227T mutant mice.

    Directory of Open Access Journals (Sweden)

    Elisabeth Kemter

    Full Text Available Uromodulin-associated kidney disease (UAKD summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD mutation involved. It is often characterized by hyperuricemia, gout, alteration of urine concentrating ability, as well as a variable rate of disease progression inconstantly leading to renal failure and histological alterations of the kidneys. We recently established the two Umod mutant mouse lines Umod(C93F and Umod(A227T on the C3H inbred genetic background both showing kidney defects analogous to those found in human UAKD patients. In addition, disease symptoms were revealed that were not yet described in other published mouse models of UAKD. To examine if further organ systems and/or metabolic pathways are affected by Umod mutations as primary or secondary effects, we describe a standardized, systemic phenotypic analysis of the two mutant mouse lines Umod(A227T and Umod(C93F in the German Mouse Clinic. Different genotypes as well as different ages were tested. Beside the already published changes in body weight, body composition and bone metabolism, the influence of the Umod mutation on energy metabolism was confirmed. Hematological analysis revealed a moderate microcytic and erythropenic anemia in older Umod mutant mice. Data of the other analyses in 7-10 month-old mutant mice showed single small additional effects.

  20. Development of the method for treatment for bone metastasis by using disequilibrium-type alpha particle emitting in vivo generator: 227Th-EDTMP

    International Nuclear Information System (INIS)

    To evaluate the efficacy of an alpha emitting radiopharmaceutical, 227Th-EDTMP for treatment of bone metastasis, 1) the process of bone metastasis on rats were monitored by radiography and gamma scintigraphy, and 2) 227Th-EDTMP were administered to bone metastasis model rats and assessed its palliation effect by von Frey filament test and measured tumor size. Two weeks after tumor cell inoculation, rats showed osteolytic change on cell inoculated site and bone lesion was detected by scintigraphy. In the therapy study, the rats showed no toxic effect by 227Th-EDTMP. However, the tumor volume size was increased with time and the bone pain palliation was comparable to control groups. Further experiment was necessary. (author)

  1. Developing 226Ra and 227Ac age-dating techniques for nuclear forensics to gain insight from concordant and non-concordant radiochronometers

    International Nuclear Information System (INIS)

    The model age or 'date of purification' of a nuclear material is an important nuclear forensic signature. In this study, chemical separation and MC-ICP-MS measurement techniques were developed for 226 Ra and 227Ac: grand-daughter nuclides in the 238U and 235U decay chains respectively. The 230Th-234U, 226Ra-238U, 231Pa-235U, and 227Ac-235U radiochronometers were used to calculate model ages for CRM-U100 standard reference material and two highly-enriched pieces of uranium metal from the International Technical Working Group Round Robin 3 Exercise. In conclusion, the results demonstrate the accuracy of the 226Ra-238U and 227Ac-235U chronometers and provide information about nuclide migration during uranium processing

  2. Developing 226Ra and 227Ac age-dating techniques for nuclear forensics to gain insight from concordant and non-concordant radiochronometers

    International Nuclear Information System (INIS)

    The model age or 'date of purification' of a nuclear material is an important nuclear forensic signature. In this study, chemical separation and MC-ICP-MS measurement techniques were developed for 226Ra and 227Ac: grand-daughter nuclides in the 238U and 235U decay chains, respectively. The 230Th-234U, 226Ra-238U, 231Pa-235U, and 227Ac-235U radiochronometers were used to calculate model ages for CRM-U100 standard reference material and two highly-enriched pieces of uranium metal from the International Technical Working Group Round Robin 3 Exercise. Results demonstrate the accuracy of the 226Ra-238U and 227Ac-235U chronometers and provide information about nuclide migration during uranium processing. (author)

  3. Assessment of long-term radiotoxicity after treatment with the low-dose-rate alpha-particle-emitting radioimmunoconjugate {sup 227}Th-rituximab

    Energy Technology Data Exchange (ETDEWEB)

    Dahle, Jostein; Heyerdahl, Helen; Hjelmerud, Anne Kristine; Larsen, Roy H. [Oslo University Hospital, Department of Radiation Biology, The Norwegian Radium Hospital, Oslo (Norway); Jonasdottir, Thora J. [Norwegian School of Veterinary Science, Small Animal Section, Department of Companion Animal Clinical Sciences, Oslo (Norway); Nesland, Jahn M. [Oslo University Hospital, Division of Pathology, The Norwegian Radium Hospital, Oslo (Norway); University of Oslo, Faculty Division The Norwegian Radium Hospital, Medical Faculty, Oslo (Norway); Borrebaek, Joergen [Algeta AS, Oslo (Norway)

    2010-01-15

    The anti-CD20 antibody rituximab labelled with the {alpha}-particle-emitting radionuclide {sup 227}Th is of interest as a radiotherapeutic agent for treatment of lymphoma. Complete regression of human lymphoma Raji xenografts in 60% of mice treated with 200 kBq/kg {sup 227}Th-rituximab has been observed. To evaluate possible late side effects of {sup 227}Th-rituximab, the long-term radiotoxicity of this potential radiopharmaceutical was investigated. BALB/c mice were injected with saline, cold rituximab or 50, 200 or 1,000 kBq/kg {sup 227}Th-rituximab and followed for up to 1 year. In addition, nude mice with Raji xenografts treated with various doses of {sup 227}Th-rituximab were also included in the study. Toxicity was evaluated by measurements of mouse body weight, white blood cell (WBC) and platelet counts, serum clinical chemistry parameters and histological examination of tissues. Only the 1,000 kBq/kg dosage resulted in decreased body weight of the BALB/c mice. There was a significant but temporary decrease in WBC and platelet count in mice treated with 400 and 1,000 kBq/kg {sup 227}Th-rituximab. Therefore, the no-observed-adverse-effect level (NOAEL) was 200 kBq/kg. The maximum tolerated activity was between 600 and 1,000 kBq/kg. No significant signs of toxicity were observed in histological sections in any examined tissue. There were significantly (p < 0.05), but transiently, higher concentrations of serum bile acids and aspartate aminotransferase in mice treated with either {sup 227}Th-rituximab or non-labelled antibody when compared with control mice. The maximum tolerated dose to bone marrow was between 2.1 and 3.5 Gy. Therapeutically relevant dose levels of {sup 227}Th-rituximab were well tolerated in mice. Bone marrow suppression, as indicated by decrease in WBC count, was the dose-limiting radiotoxicity. These toxicity data together with anti-tumour activity data in a CD20-positive xenograft mouse model indicate that therapeutic effects could be

  4. A synchrotron study of Na2.27Ho7.73(SiO46O0.72

    Directory of Open Access Journals (Sweden)

    Luis Fuentes

    2009-05-01

    Full Text Available A well crystallized powder sample of sodium holmium orthosilicate oxyapatite, Na2.27Ho7.73(SiO46O0.72, was obtained after mechanical milling and thermal treatment at 1123 K. Crystal structure analysis was performed from the results of Rietveld refinement of the synchrotron diffraction data. As in other rare-earth orthosilicate apatites, sodium cations appear located sharing with holmium the 4f Wyckoff position at the center of a tricapped trigonal prism. In its turn, holmium almost fully occupies the 6h position at the center of a seven-coordinated pentagonal bipyramid. A small quantity of Na atoms was found at this site. No vacancies are present in the two independent crystallographic sites available for Ho and Na atoms.

  5. Accelerating growth of HFC-227ea (1,1,1,2,3,3,3-heptafluoropropane) in the atmosphere

    DEFF Research Database (Denmark)

    Laube, J.C.; Martinerie, P.; Witrant, E.;

    2010-01-01

    firn air to 0.59 ppt in the current northern mid-latitudinal upper troposphere. Firn air samples collected in Greenland were used to reconstruct a history of atmospheric abundance. Year-on-year increases were deduced, with acceleration in the growth rate from 0.029 ppt per year in 2000 to 0.056 ppt per......We report the first measurements of 1,1,1,2,3,3,3-heptafluoropropane (HFC-227ea), a substitute for ozone depleting compounds, in air samples originating from remote regions of the atmosphere and present evidence for its accelerating growth. Observed mixing ratios ranged from below 0.01 ppt in deep...... the reconstructed atmospheric trend and suggest that current "bottom-up" estimates of global emissions for 2005 are too high by a factor of three....

  6. A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)

    NARCIS (Netherlands)

    Kelly, DJ; Wilkinson-Berka, JL; Allen, TJ; Cooper, ME; Skinner, SL

    1998-01-01

    Background. The tissue renin-angiotensin system (RAS) may modulate the structural and functional changes that occur in the diabetic kidney. Methods. Hypertensive transgenic (mREN-2)27 rat (TGR) that exhibit increased tissue renin expression were administered streptozotocin (STZ, diabetic) or citrate

  7. Modifications in Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters After α-Particle-Emitting {sup 227}Th-trastuzumab Therapy of HER2-Expressing Ovarian Cancer Xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Heyerdahl, Helen, E-mail: Helen.Heyerdahl@rr-research.no [Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital - The Norwegian Radium Hospital, Oslo (Norway); Røe, Kathrine [Department of Oncology, Division of Medicine, Akershus University Hospital, Lørenskog (Norway); Brevik, Ellen Mengshoel [Department of Research and Development, Algeta ASA, Oslo (Norway); Dahle, Jostein [Nordic Nanovector AS, Oslo (Norway)

    2013-09-01

    Purpose: The purpose of this study was to investigate the effect of α-particle-emitting {sup 227}Th-trastuzumab radioimmunotherapy on tumor vasculature to increase the knowledge about the mechanisms of action of {sup 227}Th-trastuzumab. Methods and Materials: Human HER2-expressing SKOV-3 ovarian cancer xenografts were grown bilaterally in athymic nude mice. Mice with tumor volumes 253 ± 36 mm{sup 3} (mean ± SEM) were treated with a single injection of either {sup 227}Th-trastuzumab at a dose of 1000 kBq/kg body weight (treated group, n=14 tumors) or 0.9% NaCl (control group, n=10 tumors). Dynamic T1-weighted contrast-enhanced magnetic resonance imaging (DCEMRI) was used to study the effect of {sup 227}Th-trastuzumab on tumor vasculature. DCEMRI was performed before treatment and 1, 2, and 3 weeks after therapy. Tumor contrast-enhancement curves were extracted voxel by voxel and fitted to the Brix pharmacokinetic model. Pharmacokinetic parameters for the tumors that underwent radioimmunotherapy were compared with the corresponding parameters of control tumors. Results: Significant increases of k{sub ep}, the rate constant of diffusion from the extravascular extracellular space to the plasma (P<.05), and k{sub el,} the rate of clearance of contrast agent from the plasma (P<.01), were seen in the radioimmunotherapy group 2 and 3 weeks after injection, compared with the control group. The product of k{sub ep} and the amplitude parameter A, associated with increased vessel permeability and perfusion, was also significantly increased in the radioimmunotherapy group 2 and 3 weeks after injection (P<.01). Conclusions: Pharmacokinetic modeling of MRI contrast-enhancement curves evidenced significant alterations in parameters associated with increased tumor vessel permeability and tumor perfusion after {sup 227}Th-trastuzumab treatment of HER2-expressing ovarian cancer xenografts.

  8. Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps.

    Science.gov (United States)

    Liu, Weizhi; Zhao, Rui; McFarland, Craig; Kieft, Jeffrey; Niedzwiecka, Anna; Jankowska-Anyszka, Marzena; Stepinski, Janusz; Darzynkiewicz, Edward; Jones, David N M; Davis, Richard E

    2009-11-01

    The eukaryotic translation initiation factor eIF4E recognizes the mRNA cap, a key step in translation initiation. Here we have characterized eIF4E from the human parasite Schistosoma mansoni. Schistosome mRNAs have either the typical monomethylguanosine (m(7)G) or a trimethylguanosine (m(2,2,7)G) cap derived from spliced leader trans-splicing. Quantitative fluorescence titration analyses demonstrated that schistosome eIF4E has similar binding specificity for both caps. We present the first crystal structure of an eIF4E with similar binding specificity for m(7)G and m(2,2,7)G caps. The eIF4E.m(7)GpppG structure demonstrates that the schistosome protein binds monomethyl cap in a manner similar to that of single specificity eIF4Es and exhibits a structure similar to other known eIF4Es. The structure suggests an alternate orientation of a conserved, key Glu-90 in the cap-binding pocket that may contribute to dual binding specificity and a position for mRNA bound to eIF4E consistent with biochemical data. Comparison of NMR chemical shift perturbations in schistosome eIF4E on binding m(7)GpppG and m(2,2,7)GpppG identified key differences between the two complexes. Isothermal titration calorimetry demonstrated significant thermodynamics differences for the binding process with the two caps (m(7)G versus m(2,2,7)G). Overall the NMR and isothermal titration calorimetry data suggest the importance of intrinsic conformational flexibility in the schistosome eIF4E that enables binding to m(2,2,7)G cap. PMID:19710013

  9. The prevalence of ABCB1:c.227_230delATAG mutation in affected dog breeds from European countries.

    Science.gov (United States)

    Firdova, Zuzana; Turnova, Evelina; Bielikova, Marcela; Turna, Jan; Dudas, Andrej

    2016-06-01

    Deletion of 4-base pairs in the canine ABCB1 (MDR1) gene, responsible for encoding P-glycoprotein, leads to nonsense frame-shift mutation, which causes hypersensitivity to macrocyclic lactones drugs (e.g. ivermectin). To date, at least 12 purebred dog breeds have been found to be affected by this mutation. The aim of this study was to update information about the prevalence of ABCB1 mutation (c.227_230delATAG) in predisposed breeds in multiple European countries. This large scale survey also includes countries which were not involved in previous studies. The samples were collected in the period from 2012 to 2014. The overview is based on genotyping data of 4729 individuals. The observed mutant allele frequencies were 58.5% (Smooth Collie), 48.3% (Rough Collie), 35% (Australian Shepherd), 30.3% (Shetland Sheepdog), 28.1% (Silken Windhound), 26.1% (Miniature Australian Shepherd), 24.3% (Longhaired Whippet), 16.2% (White Swiss Shepherd) and 0% (Border Collie). The possible presence of an ABCB1 mutant allele in Akita-Inu breed has been investigated with negative results. This information could be helpful for breeders in optimization of their breeding strategy and for veterinarians when prescribing drug therapy for dogs of predisposed breeds. PMID:27234542

  10. A sorption study of 85Sr, 137Cs and 227Th onto glacial sand as part of an interlaboratory exercise

    International Nuclear Information System (INIS)

    A number of radionuclide batch sorption tests have been carried out on core material from boreholes on the BNFL Drigg site, Cumbria, as part of an intercomparison exercise with BNFL, Sellafield. This report describes the nature of the materials used, the method and the results of the BGS side of the interlaboratory exercise. Another report will describe the intercomparison. These experiments formed part of a wider programme of laboratory tests by BGS to ascertain the sorption properties of the Drigg sands and silts as an information base for designing artificial in-situ radionuclide migration experiments on site at Drigg. Three radionuclides were used, 85Sr, 137Cs, and 227Th. Interestingly, although sorption of strontium was about 15 times less than for thorium, the pattern of sorption as a function of borehole depth i.e. mineralogical composition, was very similar. Sorption of 137Cs was found to be non-linear, depending strongly on caesium concentration in the groundwater. Isotherm fits were used to determine the energy of sorption in the ion exchange process, the mechanism responsible for uptake. There is a need for a standard batch sorption method to be in common use. (author)

  11. Development of separation technology for the removal of radium-223 from decayed thorium-227 in drug formulations. Material screening and method development.

    Science.gov (United States)

    Frenvik, Janne Olsen; Kristensen, Solveig; Ryan, Olav B

    2016-08-01

    Targeted thorium conjugates are currently being investigated as a new class of alpha-radiopharmaceuticals. The natural decay of thorium-227 ((227)Th) results in the ingrowth of radium-223 ((223)Ra). Consideration must, therefore, be given to define acceptable limits of (223)Ra in the drug product at the time of dose administration. By effective sequestration of (223)Ra, we aim to improve the radiochemical purity and extend the effective user window of drug products containing (227)Th. (223)Ra is the first progeny of (227)Th and the only one with a long half-life (days). We have, therefore, focused on the removal of this specific species since the progenies of (223)Ra will have a very limited lifetime in the formulation once (223)Ra is removed. In this study, we investigated a multitude of materials for their ability to reduce the (223)Ra level by: (1) passive diffusion or (2) by cartridge filtration on gravity columns. In addition, we probe the compatibility of these materials in the presence of antibody trastuzumab to assess the level of protein binding and estimate the quenching of radiolysis by binding of radionuclides. A screening matrix of organic and inorganic materials was established, i.e. strontium and calcium alginate gel beads, distearoyl phosphatidylglycerol (DSPG) liposomes, ceramic hydroxyapatite, Zeolite UOP type 4A and cation exchange resins AG50W-X8 and SOURCE 30S. First, passive diffusional uptake of (223)Ra by suspended materials present in the formulation was measured as a decrease in sample radioactivity after separation. Second, selected materials were packed on gravity columns in order to evaluate the efficiency of column separation versus diffusional adsorption. The retention of (223)Ra and (227)Th were characterized by measuring the radioactivity in the eluate and on the columns. Finally, the compatibility between trastuzumab, as a selected model antibody, and suspensions of the binding materials was analyzed during storage of the drug

  12. Quantitative kinetic analysis of PET amyloid imaging agents [11C]BF227 and [18F]FACT in human brain

    International Nuclear Information System (INIS)

    Introduction: The purpose of this study was to compare two amyloid imaging agents, [11C]BF227 and [18F]FACT (derivative from [11C]BF227) through quantitative pharmacokinetics analysis in human brain. Methods: Positron emission tomography studies were performed on six elderly healthy control (HC) subjects and seven probable Alzheimer’s disease (AD) patients with [11C]BF227 and 10 HC subjects and 10 probable AD patients with [18F]FACT. Data from nine regions of interest were analyzed by several approaches, namely non-linear least-squared fitting methods with arterial input functions (one-tissue compartment model(1TCM), two-tissue compartment model (2TCM)), Logan plot, and linearized methods with reference region (Reference Logan plot (RefLogan), MRTM0, MRTM2). We also evaluated SUV and SUVR for both tracers. The parameters estimated by several approaches were compared between two tracers for detectability of differences between HC and AD patients. Results: For [11C]BF227, there were no significant difference of VT (2TCM, 1TCM) and SUV in all regions (Student t-test; p < 0.05) and significant differences in the DVRs (Logan, RefLogan, and MRTM2) and SUVRs in six neocortical regions (p < 0.05) between the HC and AD groups. For [18F]FACT, significant differences in DVRs (RefLogan, MRTM0, and MRTM2) were observed in more than four neocortical regions between the HC and AD groups (p < 0.05), and the significant differences were found in SUVRs for two neocortical regions (inferior frontal coretex and lateral temporal coretex). Our results showed that both tracers can clearly distinguish between HC and AD groups although the pharmacokinetics and distribution patterns in brain for two tracers were substantially different. Conclusion: This study revealed that although the PET amyloid imaging agents [11C]BF227 and [18F]FACT have similar chemical and biological properties, they have different pharmacokinetics, and caution must be paid for usage of the tracers

  13. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Science.gov (United States)

    2010-01-01

    ... Category 1(TBq) Category 1(Ci) Category 2(TBq) Category 2(Ci) Actinium-227 20 540 0.2 5.4 Americium-241 60... 2 54 Strontium-90 1,000 27,000 10 270 Thorium-228 20 540 0.2 5.4 Thorium-229 20 540 0.2 5.4...

  14. Planetary wave seasonality from meteor wind measurements at 7.4° S and 22.7° S

    Science.gov (United States)

    Araújo, L. R.; Lima, L. M.; Batista, P. P.; Clemesha, B. R.; Takahashi, H.

    2014-05-01

    In this study we have used wind observation data from the mesosphere and lower thermosphere (MLT) region, obtained from meteor radar measurements in São João do Cariri (7.4° S, 36.5° W) from July 2004 to December 2008 and in Cachoeira Paulista (22.7° S, 45.0° W) from January 2002 to July 2006 and from September 2007 to November 2008. From the spectral analysis it was possible to identify the presence of planetary-scale oscillations in the hourly winds for the two latitudes and to study their transient character, which allowed elaboration of a climatology of planetary oscillation signatures. Planetary waves with periods near 2-days, 6-7 days, and 16 days were focussed on in this study. The quasi-2-day waves in the meteoric winds showed a seasonal cycle, with intense amplitudes occurring after the austral summer solstice and extending until the end of the season. The vertical wavelengths of the 2-day wave over Cachoeira Paulista were larger than those at São João do Cariri. A possible modulation of the quasi-2-day wave amplitudes by the quasi-biennial oscillation (QBO) has been observed only at São João do Cariri. The 6-7 day oscillations presented more intense amplitudes during August-November but were present with lower amplitudes during March-April at both sites. The 6-7 day vertical wavelengths over São João do Cariri were larger than at Cachoeira Paulista. The 6-7 day amplitudes exhibited intra-seasonal and annual behavior, however, there was no clear evidence of QBO modulation. The 16-day oscillations showed a seasonal cycle at São João do Cariri, with amplifications from austral spring to mid-summer and weaker amplitudes from autumn until early winter, however, there was no clear seasonality over Cachoeira Paulista. The 16-day vertical wavelengths have assumed values of λz ~ 45-85 km over both sites. 16-day wave amplitudes at the two sites showed different long-term behaviors.

  15. Absolute rate constant and O(3P yield for the O(1D+N2O reaction in the temperature range 227 K to 719 K

    Directory of Open Access Journals (Sweden)

    S. A. Carl

    2008-10-01

    Full Text Available The absolute rate constant for the reaction that is the major source of stratospheric NOx, O(1D+N2O → products, has been determined in the temperature range 227 K to 719 K, and, in the temperature range 248 K to 600 K, the fraction of the reaction that yields O(3P. Both the rate constants and product yields were determined using a recently-developed chemiluminescence technique for monitoring O(1D that allows for higher precision determinations for both rate constants, and, particularly, O(3P yields, than do other methods. We found the rate constant, kR1, to be essentially independent of temperature between 400 K and 227 K, having a value of (1.37±0.11×10−10 cm3 s−1, and for temperatures greater than 450 K a marked decrease in rate constant was observed, with a rate constant of only (0.94±0.11×10−10 cm3 s−1 at 719 K. The rate constants determined over the 227 K–400 K range show very low scatter and are significantly greater, by 20% at room temperature and 15% at 227 K, than the current recommended values. The fraction of O(3P produced in this reaction was determined to be 0.002±0.002 at 250 K rising steadily to 0.010±0.004 at 600 K, thus the channel producing O(3P can be entirely neglected in atmospheric kinetic modeling calculations. A further result of this study is an expression of the relative quantum yields as a function of temperature for the chemiluminescence reactions (kCL1C2H + O(1D → CH(A + CO and (kCL2C2H + O(3P → CH(A + CO, both followed by CH(A → CH(X + hν, as kCL1(T/kCL2(T=(32.8T−3050/(6.29T+398.

  16. Combined renin inhibition/(pro)renin receptor blockade in diabetic retinopathy--a study in transgenic (mREN2)27 rats.

    Science.gov (United States)

    Batenburg, Wendy W; Verma, Amrisha; Wang, Yunyang; Zhu, Ping; van den Heuvel, Mieke; van Veghel, Richard; Danser, A H Jan; Li, Qiuhong

    2014-01-01

    Dysfunction of renin-angiotensin system (RAS) contributes to the pathogenesis of diabetic retinopathy (DR). Prorenin, the precursor of renin is highly elevated in ocular fluid of diabetic patients with proliferative retinopathy. Prorenin may exert local effects in the eye by binding to the so-called (pro)renin receptor ((P)RR). Here we investigated the combined effects of the renin inhibitor aliskiren and the putative (P)RR blocker handle-region peptide (HRP) on diabetic retinopathy in streptozotocin (STZ)-induced diabetic transgenic (mRen2)27 rats (a model with high plasma prorenin levels) as well as prorenin stimulated cytokine expression in cultured Müller cells. Adult (mRen2)27 rats were randomly divided into the following groups: (1) non-diabetic; (2) diabetic treated with vehicle; (3) diabetic treated with aliskiren (10 mg/kg per day); and (4) diabetic treated with aliskiren+HRP (1 mg/kg per day). Age-matched non-diabetic wildtype Sprague-Dawley rats were used as control. Drugs were administered by osmotic minipumps for three weeks. Transgenic (mRen2)27 rat retinas showed increased apoptotic cell death of both inner retinal neurons and photoreceptors, increased loss of capillaries, as well as increased expression of inflammatory cytokines. These pathological changes were further exacerbated by diabetes. Aliskiren treatment of diabetic (mRen2)27 rats prevented retinal gliosis, and reduced retinal apoptotic cell death, acellular capillaries and the expression of inflammatory cytokines. HRP on top of aliskiren did not provide additional protection. In cultured Müller cells, prorenin significantly increased the expression levels of IL-1α and TNF-α, and this was completely blocked by aliskiren or HRP, their combination, (P)RR siRNA and the AT1R blocker losartan, suggesting that these effects entirely depended on Ang II generation by (P)RR-bound prorenin. In conclusion, the lack of effect of HRP on top of aliskiren, and the Ang II-dependency of the ocular

  17. Cloning, functional organization, transcript studies, and phylogenetic analysis of the complete nitrogenase structural genes (nifHDK2) and associated genes in the archaeon Methanosarcina barkeri 227.

    OpenAIRE

    Chien, Y T; Zinder, S. H.

    1996-01-01

    Determination of the nucleotide sequence of the nitrogenase structural genes (nifHDK2) from Methanosarcina barkeri 227 was completed in this study by cloning and sequencing a 2.7-kb BamHI fragment containing the 3' end of nifK2 and 1,390 bp of the nifE2-homologous genes. Open reading frame nifK2 is 1,371 bp long including the stop codon TAA and encodes a polypeptide of 456 amino acids. Phylogenetic analysis of the deduced amino acid sequences of the nifK2 and nifE2 gene products from M. barke...

  18. Development of separation technology for the removal of radium-223 from decayed thorium-227 in drug formulations. Material screening and method development.

    Science.gov (United States)

    Frenvik, Janne Olsen; Kristensen, Solveig; Ryan, Olav B

    2016-08-01

    Targeted thorium conjugates are currently being investigated as a new class of alpha-radiopharmaceuticals. The natural decay of thorium-227 ((227)Th) results in the ingrowth of radium-223 ((223)Ra). Consideration must, therefore, be given to define acceptable limits of (223)Ra in the drug product at the time of dose administration. By effective sequestration of (223)Ra, we aim to improve the radiochemical purity and extend the effective user window of drug products containing (227)Th. (223)Ra is the first progeny of (227)Th and the only one with a long half-life (days). We have, therefore, focused on the removal of this specific species since the progenies of (223)Ra will have a very limited lifetime in the formulation once (223)Ra is removed. In this study, we investigated a multitude of materials for their ability to reduce the (223)Ra level by: (1) passive diffusion or (2) by cartridge filtration on gravity columns. In addition, we probe the compatibility of these materials in the presence of antibody trastuzumab to assess the level of protein binding and estimate the quenching of radiolysis by binding of radionuclides. A screening matrix of organic and inorganic materials was established, i.e. strontium and calcium alginate gel beads, distearoyl phosphatidylglycerol (DSPG) liposomes, ceramic hydroxyapatite, Zeolite UOP type 4A and cation exchange resins AG50W-X8 and SOURCE 30S. First, passive diffusional uptake of (223)Ra by suspended materials present in the formulation was measured as a decrease in sample radioactivity after separation. Second, selected materials were packed on gravity columns in order to evaluate the efficiency of column separation versus diffusional adsorption. The retention of (223)Ra and (227)Th were characterized by measuring the radioactivity in the eluate and on the columns. Finally, the compatibility between trastuzumab, as a selected model antibody, and suspensions of the binding materials was analyzed during storage of the drug

  19. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  20. Fractionated therapy of HER2-expressing breast and ovarian cancer xenografts in mice with targeted alpha emitting 227Th-DOTA-p-benzyl-trastuzumab.

    Directory of Open Access Journals (Sweden)

    Helen Heyerdahl

    Full Text Available BACKGROUND: The aim of this study was to investigate therapeutic efficacy and normal tissue toxicity of single dosage and fractionated targeted alpha therapy (TAT in mice with HER2-expressing breast and ovarian cancer xenografts using the low dose rate radioimmunoconjugate (227Th-DOTA-p-benzyl-trastuzumab. METHODOLOGY/PRINCIPAL FINDINGS: Nude mice carrying HER2-overexpressing subcutaneous SKOV-3 or SKBR-3 xenografts were treated with 1000 kBq/kg (227Th-trastuzumab as single injection or four injections of 250 kBq/kg with intervals of 4-5 days, 2 weeks, or 4 weeks. Control animals were treated with normal saline or unlabeled trastuzumab. In SKOV-3 xenografts tumor growth to 10-fold size was delayed (p<0.01 and survival with tumor diameter less than 16 mm was prolonged (p<0.05 in all TAT groups compared to the control groups. No statistically significant differences were seen among the treated groups. In SKBR-3 xenografts tumor growth to 10-fold size was delayed in the single injection and 4-5 days interval groups (p<0.001 and all except the 4 weeks interval TAT group showed improved survival to the control groups (p<0.05. Toxicity was assessed by blood cell counts, clinical chemistry measurements and body weight. Transient reduction in white blood cells was seen for the single injection and 4-5 days interval groups (p<0.05. No significant changes were seen in red blood cells, platelets or clinical chemistry parameters. Survival without life threatening loss of body weight was significantly prolonged in 4 weeks interval group compared to single injection group (p<0.05 for SKOV-3 animals and in 2 weeks interval group compared with the 4-5 days interval groups (p<0.05 for SKBR-3 animals. CONCLUSIONS/SIGNIFICANCE: The same concentration of radioactivity split into several fractions may improve toxicity of (227Th-radioimmunotherapy while the therapeutic effect is maintained. Thus, it might be possible to increase the cumulative absorbed radiation dose

  1. Discussion: ´Changing river courses in the western part of the Ganga-Brahmaputra delta' by Kalyan Rudra (2014), Geomorphology, 227, 87-100

    Science.gov (United States)

    Bandyopadhyay, Sunando; Das, Sayantan; Kar, Nabendu Sekhar

    2015-12-01

    Rudra (2014, Geomorphology, 227, 87-100) presented a review of geomorphic changes of the Indian part of the Ganga-Brahmaputra delta (GBD) during the last ~ 240 years, emphasising deterioration of distributary channels, effects of discharge augmentation from the Farakka barrage project into the Bhagirathi-Hugli river and the patterns of coastal erosion. The work contained many inconsistencies, improper understanding, and misrepresentation of facts. The principal of these involved (1) usage of nomenclature like GBD, Bengal basin, and their delineation; (2) discussions made on evolution and current status of the deltaic distributaries; and (3) generation and presentation of data on discharge, tides, and sea level. Besides this, most figures of the work contained positional inaccuracies and/or errors in survey years. We systematically addressed all these issues in the present discussion and offered corrected and up-to-date information wherever applicable.

  2. The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women.

    Science.gov (United States)

    Chan, Edmund; Tan, Chuen Seng; Deurenberg-Yap, Mabel; Chia, Kee Seng; Chew, Suok Kai; Tai, E Shyong

    2006-08-01

    Peroxisome proliferators activated receptor alpha (PPARalpha) regulates the transcription of several proteins involved in human lipoprotein metabolism. We screened the PPARA locus for polymorphisms in 20 unrelated subjects from each of three ethnic groups (Chinese, Malays and Asian Indians). Only the V227A polymorphism was observed. We genotyped 4248 subjects (2899 Chinese, 761 Malay and 588 Asian Indians) and found allele frequencies for the A227 allele of 0.04 in Chinese, 0.006 in Malays and 0.003 in Asian Indians. We examined the associations between this polymorphism and serum lipid concentrations in Chinese. In women, but not in men, the presence of the A227 allele was associated with lower serum concentrations of total cholesterol [5.38mmol/l (95%CI: 5.22-5.54) versus 5.21mmol/l (95%CI: 4.99-5.43), p=0.047] and triglycerides [1.19mmol/l (95%CI: 1.10-1.28) versus 1.09mmol/l (95%CI: 0.98-1.21), p=0.048]. We also found that the V227A polymorphism modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentration (p-value for interaction=0.049). Our findings implicate PPARalpha in the lipid lowering associated with diets high in PUFA and suggests that genetic variation at the PPARA locus may determine the lipid response to changes in PUFA intake. PMID:16288935

  3. Application of USP inlet extensions to the TSI impactor system 3306/3320 using HFA 227 based solution metered dose inhalers.

    Science.gov (United States)

    Mogalian, Erik; Myrdal, Paul Brian

    2005-12-01

    The objective of this study was to further evaluate the need for a vertical inlet extension when testing solution metered dose inhalers using the TSI Model 3306 Impactor Inlet in conjunction with the TSI Model 3320 Aerodynamic Particle Sizer (APS). The configurations tested using the TSI system were compared to baseline measurements that were performed using the Andersen Mark II 8-stage cascade impactor (ACI). Seven pressurized solution metered dose inhalers were tested using varied concentrations of beclomethasone dipropionate (BDP), ethanol, and HFA 227 propellant. The inhalers were tested with the cascade impactor, and with the TSI system. The TSI system had three different configurations as the manufacturer provided (0 cm) or with inlet extensions of 20 and 40 cm. The extensions were located between the USP inlet and the Model 3306 Impactor Inlet. There were no practical differences between each system for the stem, actuator, or USP inlet. The fine particle mass (aerodynamic mass < 4.7 microm) was affected by extension length and correlated well with the ACI when an extension was present. APS particle size measurements were unaffected by the extension lengths and correlated well to particle size determined from the ACI analysis. It has been confirmed that an inlet extension may be necessary for the TSI system in order to give mass results that correlate to the ACI, especially for formulations having significant concentrations of low volatility excipients. Additionally, the results generated from this study were used to evaluate the product performance of HFA 227 based solution formulations that contain varying concentrations of ethanol as a cosolvent. PMID:16316853

  4. Discovery of Soft Spectral Component and Transient 22.7s Quasi Periodic Oscillations of SAX J2103.5+4545

    CERN Document Server

    Inam, S C; Swank, J H; Stark, M J

    2004-01-01

    XMM-Newton observed SAX J2103.5+4545 on January 6, 2003, while RXTE was monitoring the source. Using RXTE-PCA dataset between December 3, 2002 and January 29, 2003, the spin period and spin-up rate at the date of XMM-Newton observations were found to be $\\simeq 354.794$ s and $\\simeq 7.4\\times 10^{-13}$ Hz/s, respectively. The XMM-Newton observation revealed a quasi-periodic oscillation (QPO) corresponding to a mean period of 22.7s, the first QPO reported for this source, enabling us to estimate the Keplerian frequency at the inner radius of the disk to be $\\simeq 4.40\\times 10^{-3}$ Hz or $\\simeq 4.12\\times 10^{-3}$ Hz using a Keplerian or a beat frequency model. Using these frequencies, and a simple accretion disk model, for which the total accretion torque is similar to the material torque, we found the magnetic field of the neutron star to be $\\sim 7\\times 10^{12}$ Gauss and and the distance to the source to be $\\sim 3.2$ kpc. We also discovered a soft component modeled as a blackbody with kT $\\sim 1.90$ ...

  5. Chronic estrogen treatment in female transgenic (mRen2)27 hypertensive rats augments endothelium-derived nitric oxide release.

    Science.gov (United States)

    Li, P; Ferrario, C M; Ganten, D; Brosnihan, K B

    1997-06-01

    Postmenopausal estrogen replacement therapy is associated with a reduction in cardiovascular events in women, but the mechanisms for this protection are unclear, especially in hypertensive subjects. In this study we investigated the effects of 17beta-estradiol (E2) treatment on blood pressure and endothelial function of transgenic [(mRen2)27] hypertensive and normotensive rats. Thirty female transgenic negative [Tg(-)] and hypertensive positive [Tg(+)] rats were ovariectomized and received either E2 (1.5 mg/rat, subcutaneously, for 3 weeks) or placebo. Chronic 17beta-estradiol treatment lowered mean blood pressure in both Tg hypertensive (159 +/- 4 v 145 +/- 4 mm Hg, P calcium ionophore (A23187)-induced endothelium-dependent relaxation was less potent in Tg(+) as compared to Tg(-) rats and was enhanced by E2 treatment only in Tg(+) animals. There were no differences in the vasodilator responses elicited by sodium nitroprusside. Removal of endothelium and blockade of NO production abolished the endothelium-dependent vasodilation. The selective NO synthase inhibitor, N(G)-monomethyl-L-arginine (LMMNA), was used to evaluate indirectly the basal contribution of NO in vascular rings. The response to LMMNA was attenuated in untreated Tg(+) as compared to Tg(-) rats. E2 treatment augmented the contraction response to NOS inhibition in both Tg(+) and Tg(-) rats, resulting in a response in Tg(+) rats that was no different from Tg(-) rats. These results indicate that untreated, surgically ovariectomized hypertensive rats show deficiencies in endothelial function, which can be improved by estrogen replacement.

  6. Effect of pressurized solution nitriding on phase changes and mechanical properties of ferritic Fe–22.7Cr–2.4Mo stainless steel

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadzadeh, Roghayeh, E-mail: r_mohammadzadeh@sut.ac.ir; Akbari, Alireza, E-mail: akbari@sut.ac.ir

    2014-01-13

    Pressurized solution nitriding (PSN) of ferritic Fe–22.7Cr–2.4Mo stainless steel at 1200 °C in nitrogen gas under pressure of 0.25 MPa for different times has been investigated. The structure and mechanical properties were characterized using X-ray diffraction, optical microscopy, scanning electron microscopy and tensile testing. Phase transformation of ferrite to austenite starts from the sample surface and grows further into the core with increasing nitriding time. A fully austenitic structure was achieved after 9 h nitriding for plates of 2 mm thick. Strip-like chromium nitride precipitates with discontinuous morphology are found in the edges of the sample nitrided for 12 h. The average solute nitrogen content of austenite phase was estimated based on lattice parameter calculations to vary from 1.25 to 1.75 wt%. The yield strength is monotonically increased above 900 MPa with increasing the PSN time. The solution nitrided samples for 6 h exhibit high elongation to fracture (above 30%) and high tensile strength (above 1000 MPa). Solution nitriding changes the fracture mode from ductile to a mixed mode inter-granular and trans-granular brittle fracture. Formation of the planar slip bands plays a major role in brittle fracture of the austenite phase. Brittle fracture is favored with precipitation of chromium nitrides. The time of the PSN should be optimized to suppress chromium nitride precipitation.

  7. Anxiolytic- and antidepressant-like effects of angiotensin-(1-7) in hypertensive transgenic (mRen2)27 rats.

    Science.gov (United States)

    Almeida-Santos, Ana Flávia; Kangussu, Lucas M; Moreira, Fabrício A; Santos, Robson A S; Aguiar, Daniele C; Campagnole-Santos, Maria José

    2016-07-01

    Angiotensin-(1-7) [Ang-(1-7)], a counter-regulatory peptide of the renin-angiotensin system (RAS) exerts its effects through the G-protein-coupled receptor Mas, which is expressed in different tissues, including the brain. Ang-(1-7) has a broad range of effects beyond the well-described cardiovascular and renal actions, including the modulation of emotional and behavioural responses. In the present study we tested the hypothesis that Ang-(1-7) could attenuate the anxiety- and depression-like behaviours observed in transgenic hypertensive (mRen2)27 rats (TGRs). We also hypothesized that Ang-(1-7) could be involved in the anxiolytic-like effect induced by ACE (angiotensin-converting enzyme) treatment in these hypertensive rats. Therefore, TGRs and Sprague-Dawley rats were subjected to the Elevated Plus Maze (EPM) test, Forced Swimming Test (FST) and Novelty Suppressed Feeding (NSF). TGRs presented a decreased percentage of entries in the open arms of the EPM test, a phenotype reversed by systemic treatment with enalapril or intracerebroventricular infusion of Ang-(1-7). It is interesting that pre-treatment with A779, a selective Mas receptor antagonist, prevented the anxiolytic-like effect induced by the ACE inhibitor. In the NSF test, TGRs showed increased latency to eating, an indicative of a higher aversion in response to a new environment. These animals also showed increased immobility in the FST. Again, Ang-(1-7) reversed this phenotype. Thus, our data showed that Ang-(1-7) can modulate anxiety- and depression-like behaviours in TGRs and warrant further investigation as a new therapy for certain psychiatric disorders. PMID:27129185

  8. LASL experience in decontamination of the environment

    International Nuclear Information System (INIS)

    This discussion represents one part of a major effort in soil decontamination at the Los Alamos site. A contaminated industrial waste line in the Los Alamos townsite was removed, and a plutonium incineration facility, and a filter building contaminated with actinium-227 were dismantled. The former plutonium handling facility has been decontaminated, and canyons and an old firing site contaminated with strontium-90 have been surveyed

  9. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  10. Testing nuclear forces by polarization transfer coefficients in d(p,p)d and d(p,d)p reactions at Ep=22.7 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Evgeny Epelbaum

    2005-05-01

    The proton to proton polarization transfer coefficients K{sub x}{sup x'}, K{sub y}{sup y'}, K{sub z}{sup x'} and the proton to deuteron polarization transfer coefficients K{sub x}{sup x'}, K{sub y}{sup y'}, K{sub z}{sup x'}, K{sub x}{sup y'z'}, K{sub y}{sup z'z'}, K{sub z}{sup y'z'}, K{sub y}{sup x'z'} and K{sub y}{sup x'x'-y'y'} have been measured in d({rvec p}, {rvec p})d and d({rvec p}, {rvec d})p reactions at E{sub p}{sup lab} = 22.7 MeV, respectively. The data have been compared to predictions of modern nuclear forces obtained by solving the three-nucleon Faddeev equations in momentum space. Realistic (semi) phenomenological nucleon-nucleon potentials combined with model three-nucleon forces and modern chiral nuclear forces have been used. The AV18, CD Bonn, Nijm I and II nucleon-nucleon interactions have been applied alone or combined with the Tucson-Melbourne 99 three-nucleon force, adjusted separately for each potential to reproduce the triton binding energy. For the AV18 potential also the Urbana IX three-nucleon force have been used. In addition chiral NN potentials in the next-to-leading-order and chiral two- and three-nucleon forces in the next-to-next-to-leading-order have been applied. Only when three-nucleon forces are included a satisfactory description of all data results. For the chiral approach the restriction to the forces in the next-to-leading order is insufficient. Only when going over to the next-to-next-to-leading order one gets a satisfactory description of the data, similar to the one obtained with the (semi) phenomenological forces.

  11. Cloning, functional organization, transcript studies, and phylogenetic analysis of the complete nitrogenase structural genes (nifHDK2) and associated genes in the archaeon Methanosarcina barkeri 227.

    Science.gov (United States)

    Chien, Y T; Zinder, S H

    1996-01-01

    Determination of the nucleotide sequence of the nitrogenase structural genes (nifHDK2) from Methanosarcina barkeri 227 was completed in this study by cloning and sequencing a 2.7-kb BamHI fragment containing the 3' end of nifK2 and 1,390 bp of the nifE2-homologous genes. Open reading frame nifK2 is 1,371 bp long including the stop codon TAA and encodes a polypeptide of 456 amino acids. Phylogenetic analysis of the deduced amino acid sequences of the nifK2 and nifE2 gene products from M. barkeri showed that both genes cluster most closely with the corresponding nif-1 gene products from Clostridium pasteurianum, consistent with our previous analyses of nifH2 and nifD2. The nifE gene product is known to be homologous to that of nifD, and our analysis shows that the branching pattern for the nifE proteins resembles that for the nifD product (with the exception of vnfE from Azotobacter vinelandii), suggesting that a gene duplication occurred before the divergence of nitrogenases. Primer extension showed that nifH2 had a single transcription start site located 34 nucleotides upstream of the ATG translation start site for nifH2, and a sequence resembling the archaeal consensus promoter sequence [TTTA(A/T)ATA] was found 32 nucleotides upstream from that transcription start site. A tract of four T's, previously identified as a transcription termination site in archaea, was found immediately downstream of the nifK2 gene, and a potential promoter was located upstream of the nifE2 gene. Hybridization with nifH2 and nifDK2 probes with M. barkeri RNA revealed a 4.6-kb transcript from N2-grown cells, large enough to harbor nifHDK genes and their internal open reading frames, while no transcript was detected from NH4(+)-grown cells. These results support a model in which the nitrogenase structural genes in M. barkeri are cotranscribed in a single NH4(+)-repressed operon. PMID:8550408

  12. Absolute rate constant and O(3P) yield for the O(1D)+N2O reaction in the temperature range 227 K to 719 K

    OpenAIRE

    Carl, S. A.; Peeters, J.; Vranckx, S.

    2008-01-01

    The absolute rate constant for the reaction that is the major source of stratospheric NOx, O(1D)+N2O → products, has been determined in the temperature range 227 K to 719 K, and, in the temperature range 248 K to 600 K, the fraction of the reaction that yields O(3P). Both the rate constants and product yields were determined using a recently-developed chemiluminescence technique for monitoring O(1D) that allows for higher precision determinations for both rate constants, and, particularl...

  13. Comparative Study on Theoretical and Machine Learning Methods for Acquiring Compressed Liquid Densities of 1,1,1,2,3,3,3-Heptafluoropropane (R227ea via Song and Mason Equation, Support Vector Machine, and Artificial Neural Networks

    Directory of Open Access Journals (Sweden)

    Hao Li

    2016-01-01

    Full Text Available 1,1,1,2,3,3,3-Heptafluoropropane (R227ea is a good refrigerant that reduces greenhouse effects and ozone depletion. In practical applications, we usually have to know the compressed liquid densities at different temperatures and pressures. However, the measurement requires a series of complex apparatus and operations, wasting too much manpower and resources. To solve these problems, here, Song and Mason equation, support vector machine (SVM, and artificial neural networks (ANNs were used to develop theoretical and machine learning models, respectively, in order to predict the compressed liquid densities of R227ea with only the inputs of temperatures and pressures. Results show that compared with the Song and Mason equation, appropriate machine learning models trained with precise experimental samples have better predicted results, with lower root mean square errors (RMSEs (e.g., the RMSE of the SVM trained with data provided by Fedele et al. [1] is 0.11, while the RMSE of the Song and Mason equation is 196.26. Compared to advanced conventional measurements, knowledge-based machine learning models are proved to be more time-saving and user-friendly.

  14. 两种试验方法对227名乡村医生潜伏性结核感染检测的结果分析

    Institute of Scientific and Technical Information of China (English)

    胡冬梅; 侯月云; 宋渝丹; 熊勇超; 耿梦杰; 何广学

    2014-01-01

    目的 获得乡村医生潜伏性结核感染(latent tuberculosis irnfection,LTBI)情况,比较γ干扰素释放试验中的QuantiFERON TB Gold In-Tube(QFT GIT)和结核菌素皮肤试验(tuberculin skin test,TST)(纯化蛋白衍生物,PPD)检测LTBI的一致性.方法 采用横断面研究,选择内蒙古自治区巴彦淖尔市临河区为研究现场,于2011年11月对临河区227名乡村医生进行问卷调查,同时采用QFT-GIT和TST两种检测方法检测乡村医生中的LTBI者.共发放227份问卷,收回有效问卷227份,回收率100.0%.采用构成比、率等统计指标描述乡村医生的基本信息和LTBI率,计算Kappa值评价QFTGIT和TST结果的一致性.结果 227名乡村医生完成QFTGIT检测,以QFT-GIT检测结果为依据(排除2名不确定结果),225名乡村医生LTBI率为44.0%(99/225).226名乡村医生完成了TST检测,以TST检测结果为依据,乡村医生LTBI率分别为59.3%(134/226)(硬结平均直径≥5 mm)、41.2%(93/226)(硬结平均直径≥10 mm)、22.6%(51/226)(硬结平均直径≥15 mm).TST以硬结平均直径5 mm为阳性临界值时,Kappa值为0.415;以10 mm为阳性临界值时,Kappa值为0.444;以15 mm为阳性临界值时,Kappa值为0.358.结论 临河区被调查的乡村医生LTBI率较高,本研究显示两种检测一致性一般,有必要开展农村结核感染控制工作,降低乡村医生的LTBI率.

  15. 人才环境感知对研发人才工作绩效、工作嵌入的影响研究——以深圳227家高新技术企业为例%An Empirical Study of the Impact of the Perceived Talent Environment on Performance and Job Embeddedness of the R & D Talents——Taking 227 High -tech Enterprises in Shenzhen as Example

    Institute of Scientific and Technical Information of China (English)

    李玉香; 刘军

    2009-01-01

    以深圳227家高新技术企业及其研发人才为样本,采用探索性分析方法,将研发人才环境感知分为人才政策环境感知、事业环境感知、生活环境感知三部分,并探讨研发人才环境感知对研发人才工作绩效和工作嵌入的影响.研究结果显示,企业对研发人才政策环境越满意,研发人才工作绩效越高;研发人才对事业环境越满意,其3-作绩效越高;对事业环境以及生活环境越满意,其工作嵌入越深.

  16. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  17. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  18. Linear free energy relationship applied to trivalent cations with lanthanum and actinium oxide and hydroxide structure

    International Nuclear Information System (INIS)

    Linear free energy relationships for trivalent cations with crystalline M2O3 and, M(OH)3 phases of lanthanides and actinides were developed from known thermodynamic properties of the aqueous trivalent cations, modifying the Sverjensky and Molling equation. The linear free energy relationship for trivalent cations is as ΔGf,MvX0=aMvXΔGn,M3+0+bMvX+βMvXrM3+, where the coefficients aMvX, bMvX, and βMvX characterize a particular structural family of MvX, rM3+ is the ionic radius of M3+ cation, ΔGf,MvX0 is the standard Gibbs free energy of formation of MvX and ΔGn,M3+0 is the standard non-solvation free energy of the cation. The coefficients for the oxide family are: aMvX=0.2705, bMvX=-1984.75 (kJ/mol), and βMvX=197.24 (kJ/molnm). The coefficients for the hydroxide family are: aMvX=0.1587, bMvX=-1474.09 (kJ/mol), and βMvX=791.70 (kJ/molnm).

  19. Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications

    OpenAIRE

    Kovatsch, Matthias; Lanter, Martin; Duquennoy, Simon

    2012-01-01

    Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that pr...

  20. Reflection asymmetry in odd-A and odd-odd actinium nuclei

    International Nuclear Information System (INIS)

    Theoretical calculations and measurements indicate that octupole correlations are at a maximum in the ground states of the odd-proton nuclei Ac and Pa. It has been expected that odd-odd nuclei should have even larger amount of octupole-octupole correlations. We have recently made measurements on the structure of 224Ac. Although spin and parity assignments could not be made, two bands starting at 354.1 and 360.0 keV have properties characteristic of reflection asymmetric shape. These two bands have very similar rotational constants and also similar alpha decay rates, which suggest similarity between the wavefunctions of these bands. These signatures provide evidence for octupole correlations in these nuclides

  1. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    OpenAIRE

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  2. 49 CFR 227.5 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... the meaning assigned by the regulations of the Surface Transportation Board (49 CFR part 120; General...) and 1 CFR part 51. You may obtain a copy of the incorporated standard from the American National... diagnostic and treatment/rehabilitative services for auditory, vestibular, and related impairments and who...

  3. 40 CFR 227.18 - Factors considered.

    Science.gov (United States)

    2010-07-01

    ....18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CRITERIA FOR... biochemical degradation during movement of the materials from a disposal site to an area of significant... organisms which may cause a public health hazard either directly or through contamination of fisheries...

  4. 49 CFR 227.121 - Recordkeeping.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating... person's representative upon written authorization by such employee; (iii) Make exposure measurement... exposure measurement records for specific locations available to regional or national labor...

  5. 49 CFR 227.119 - Training program.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating... concerning the expected range of workplace noise exposure levels associated with major categories of...

  6. Danish Media coverage of 22/7

    DEFF Research Database (Denmark)

    Hervik, Peter; Boisen, Sophie

    2013-01-01

    When the two terrorist attacks in Norway took place and the identity of terrorist, Anders Behring Breivik (ABB) was revealed, attention turned to his network relations and shared ideas with Danish radical right wing communities, including the Danish People’s Party. In this article, we focus on ABB...

  7. 40 CFR 227.21 - Uses considered.

    Science.gov (United States)

    2010-07-01

    ... limited to: (a) Commercial fishing in open ocean areas; (b) Commercial fishing in coastal areas; (c) Commercial fishing in estuarine areas; (d) Recreational fishing in open ocean areas; (e) Recreational fishing... EVALUATION OF PERMIT APPLICATIONS FOR OCEAN DUMPING OF MATERIALS Impact of the Proposed Dumping on Other...

  8. Knowledge and Attitude Toward Pain Management of 277 Orthopedics Nurses%227名骨科护理人员疼痛管理知识和态度调查分析

    Institute of Scientific and Technical Information of China (English)

    李伦兰; 倪秀梅; 甘玉云; 丁晓云; 刘玲; 张凡; 祁金梅; 汪亚兵

    2014-01-01

    Objective To explore orthopedic nurses’ knowledge of and attitude toward pain management and to provide reference for pain management. Methods A total of 277 orthopedic nurses from five Class Ⅲ Grade Ⅰ hospitals were surveyed by the nurses ’ knowledge and attitude survey regarding pain and general information questionnaire. Results Totally 65.6%of the orthopedic nurses had learned about knowledge of pain but not systematically and 95.6% thought it was indispensible to acquire pain knowledge especially about pain assessment, pain related psychology and drug therapy. Only 5.7%of the nurses obtained knowledge of pain from academic journals and only 18.1% of them always employed pain assessment tool. The mean rate of correct answer to knowledge of pain and attitude was 44.8%and the mean score was 20.02±4.27. Conclusion Orthopedic nurses lack knowledge of pain and have negative attitudes toward pain management but they have strong desire to acquire knowledge of pain, especially about pain assessment, pain related psychology and drug therapy.%目的:探讨骨科护理人员疼痛管理知识和态度,为骨科护士规范化培训及创伤病人疼痛管理提供科学依据。方法采用自行设计一般调查问卷、护理人员疼痛知识和态度调查表,对某省5所三级甲等医院227名骨科护理人员进行调查。结果本组65.6%骨科护理人员学习过疼痛知识,但不全面;62.6%和33.0%的骨科护理人员认为有必要和很有必要学习,而且非常希望通过医院开展的继续教育项目、临床教学查房形式学习,5.7%经常从学术期刊上获取疼痛相关知识;只有18.1%总是使用疼痛评估工具进行评估;疼痛评估、非药物疼痛干预措施、疼痛的药物治疗是最想获得的前3位疼痛相关知识;疼痛知识和态度问卷平均答对率为44.8%,得分为(20.02±4.27)分,“系统学习过疼痛相关知识”、“经常从学术期刊上获取疼痛相关

  9. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  10. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  11. Origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department); Origine des elements de la famille de l'uranium-235 observes dans la riviere Ellez a proximite du reacteur nucleaire experimental EL4 en cours de demantelement (Mont d'Arree - departement du Finistere). Resultats et premiers constats annee 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 ({sup 227}Ac), non born by its ascendents which are {sup 235}U and {sup 231}Pa is observed. This phenomenon is characterized by mass activities superior to these ones of {sup 235}U and able to reach these ones of {sup 238}U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil ({sup 210}Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  12. origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department)

    International Nuclear Information System (INIS)

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 (227Ac), non born by its ascendents which are 235U and 231Pa is observed. This phenomenon is characterized by mass activities superior to these ones of 235U and able to reach these ones of 238U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil (210Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  13. 两种稀土产品中放射性核素分析研究%ANALYSIS OF RADIONUCLIDES IN TWO RARE EARTH PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    周程; 孙恋君

    2009-01-01

    利用高纯锗γ谱仪对两个稀土产品氯化镧和氯化钇的样品进行能谱分析,研究经湿法冶炼工艺后的稀土产品中放射性核素的活度变化.结果表明,样品中存在天然放射性钍系和锕-铀系的核素,以及天然放射性核素~(138)La和~(176)Lu,但两个样品中所含的放射性核素不相同.氯化镧产品中锕-铀系和钍系核素放射性未达平衡,其主要子体~(224)Ra和~(227)Th的含量随时间发生明显变化,约60天达到平衡;而氯化钇产品没有这种现象.%This paper describes a study on raidoactivity change of rare-earth products after hydrometallurgy technology,using HPGe gamma spectrometer to analyze two rare earth products (LaCl_3 and YCl_3).The results show that in the two samples exist natural radionuclides of thorium series and actinium-uranium series as well as other natural radionuclides 138 La and 176 Lu.In the sample of lanthanum chloride the radioactivity of actinium-uranium series and thorium series has not reached balance,the contents of their main progenies ~(226)Ra and ~(227)Th obviously changes with the time,reaching balance 60 days later,while YCl_3 keeps stability.

  14. 7 CFR 227.30 - Responsibilities of State agencies.

    Science.gov (United States)

    2010-01-01

    ....30 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM State Agency... nutrition or public health programs; foodservice operations for children; or community action or...

  15. 7 CFR 227.36 - Requirements of needs assessment.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM State Coordinator... materials; (8) Any major child nutrition related health problems in each State; (9) Existing sources of... children and areas where nutrition education may assist in positive changes; (15) Problems encountered...

  16. Dicty_cDB: AFM227 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available DKEYKEGEKKFCVS*slsn nnrshcs*sflhfgl*wslg*gri**srsicskkykigkkcn*nfriissrflxrgsgii s Translated Amino Acid seq...SRSFGDKEYKEGEKKFCVS*slsn nnrshcs*sflhfgl*wslg*gri**srsicskkykigkkcn*nfriissrflxrgsgii s Frame B: iiifieiyy*n

  17. 1935 15' Quad #227 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  18. 49 CFR 227.103 - Noise monitoring program.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating... made under typical operating conditions using: (i) A sound level meter conforming, at a minimum, to the...-weighted SLOW response. (3) All instruments used to measure employee noise exposure shall be calibrated...

  19. 49 CFR 227.101 - Scope and applicability.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating... maintenance purposes, or (iii) Contractors who operate historic equipment in occasional service, provided that... the hearing protectors while operating the historic equipment; (2) Any direct supervisor of...

  20. 49 CFR 227.105 - Protection of employees.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Occupational Noise Exposure for Railroad Operating... appendix A of this part. (b) In assessing whether exposures exceed 115 dB(A), as set forth in paragraph (a) of this section and appendix A to this part, the apparent source of the noise exposures shall...

  1. 12 CFR 227.11 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ... credit to consumers. (c) Scope. This subpart applies to all banks and their subsidiaries, except savings... Comptroller of the Currency, in the case of national banks, banks operating under the code of laws for the... in section 1(b) of the International Banking Act of 1978 (12 U.S.C. 3101). Effective Date Note: At...

  2. 49 CFR 192.227 - Qualification of welders.

    Science.gov (United States)

    2010-10-01

    ... accordance with section 6 of API 1104 (incorporated by reference, see § 192.7) or section IX of the ASME... produces a hoop stress of less than 20 percent of SMYS by performing an acceptable test weld, for the process to be used, under the test set forth in section I of Appendix C of this part. Each welder who...

  3. Dicty_cDB: SFF227 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available yme 3 mRNA, complete cds. 58 2e-07 2 CK273593 |CK273593.1 EST719671 potato abiotic stress cDNA library Solan...xpressed sequence tag database for abiotic stressed leaves of Vitis vinifera var....332552 An expressed sequence tag database for abiotic stressed leaves of Vitis vinifera var. Chardonnay Viti... VVB158G03_410335 An expressed sequence tag database for abiotic stressed leaves of Vitis vinifera var. Char

  4. 48 CFR 227.7008 - Settlement of indemnified claims.

    Science.gov (United States)

    2010-10-01

    ... interests of the Government and is coordinated with the Department of Justice with a view to preserving any... the contractors are obtained, the settlement need not be coordinated with the Department of Justice....

  5. Viral erythrocytic necrosis: Chapter 2.2.7

    Science.gov (United States)

    Winton, James R.; Hershberger, Paul K.

    2014-01-01

    Viral erythrocytic necrosis (VEN), originally termed piscine erythrocytic necrosis, is a condition that has been reported to affect the red blood cells (RBCs) of many species of marine and anadromous fishes in both the Atlantic and Pacific Oceans (Nicholson and Reno 1981; Smail 1982; Wolf 1988; Dannevig and Thorud 1999). Fish with VEN may develop a severe anemia that can reduce their stamina, predispose them to other infections or increase the impact of other stressors (MacMillan et al. 1980; Nicholson and Reno 1981; Meyers et al. 1986; Haney et al. 1992) resulting in population-scale impacts in susceptible species (Hershberger et al. 2009).

  6. 14 CFR 93.227 - Slot use and loss.

    Science.gov (United States)

    2010-01-01

    ... lottery may not be leased after the expiration of the applicable time period specified in paragraph (b) of... operator which obtained it in the lottery. (g) This section does not apply to slots used for the...

  7. 48 CFR 1852.227-70 - New technology.

    Science.gov (United States)

    2010-10-01

    ... Administration. (For the purpose of this definition, the size standard contained in 13 CFR 121.3-8 for small...) (a) Definitions. Administrator, as used in this clause, means the Administrator of the National... invention, discovery, improvement, or innovation of the contractor, whether or not patentable or...

  8. 22 CFR Appendix A to Part 227 - Certification Regarding Lobbying

    Science.gov (United States)

    2010-04-01

    ..., Grants, Loans, and Cooperative Agreements The undersigned certifies, to the best of his or her knowledge... is a material representation of fact upon which reliance was placed when this transaction was made or... his or her knowledge and belief, that: If any funds have been paid or will be paid to any person...

  9. Dicty_cDB: SSL227 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available developmental stages Lycopersicon esculentum cDNA, mRNA sequence. 34 0.79 2 BQ515661 |BQ515661.1 EST623076 Generation...60 |BQ515660.1 EST623075 Generation of a set of potato cDNA clones for microarray

  10. Brookhaven lecture series No. 227: The Chernobyl accident

    Energy Technology Data Exchange (ETDEWEB)

    Kouts, H.

    1986-09-24

    This lecture discusses the events leading to, during, and following the Chernobyl Reactor number 4 accident. A description of the light water cooled, graphite moderated reactor, the reactor site conditions leading to meltdown is presented. The emission of radioactive effluents and the biological radiation effects is also discussed. (FI)

  11. Dicty_cDB: CHC227 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available GGTA TCCCACCAGATCT sequence update 2002. 9.10 Translated Amino Acid sequence ---xxxxxxxxxxxxxxxxi*xxx...LTGKTITLE VEGSDNIENVKTKIQDKEGIPPD Translated Amino Acid sequence (All Frames) Frame A: ---xxxxxxxxxxxxxxxxi*xxx...ENVKTKIQDKEGIPPD Frame B: ---xxmxxxxxxxxxixxxfsxxxkxwyxxfcxnpxw*xynxxklkvlxxlrmlk...pkxkt kkvfhqinxvsfspvxnwrmvvlslittfkrnplsi*fsd*evvckfl*klslvkplhxk lkvvttlrm*kqkfktkkvshqi Frame C: ---xxxxxxxxxkxxsxxxlvxxxxggxxx

  12. 40 CFR 180.227 - Dicamba; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ..., hay 2.0 Barley, straw 15.0 Corn, field, forage 3.0 Corn, field, grain 0.1 Corn, field, stover 3.0 Corn, pop, grain 0.1 Corn, pop, stover 3.0 Corn, sweet, forage 0.50 Corn, sweet, kernel plus cob with husks removed 0.04 Corn, sweet, stover 0.50 Cotton, undelinted seed 0.2 Grass, forage, fodder and hay, group...

  13. Study on laser atomic spectroscopy

    International Nuclear Information System (INIS)

    Laser atomic spectroscopic study on actinium element has been performed in many areas of spectroscopy. The study on characteristic of atomic vapor has been proceeded for copper atom and the spatial density distribution of copper vapor is measured. This experimental data has been compared with the theoretically calculated data. In spectroscopic experiment, the first and second excited states for actinium element are identified and the most efficient ionization scheme for actinium element is identified. In addition, the corrosion problem for filament material due to the heating of the actinium element has been studied. (Author)

  14. Ac, La, and Ce radioimpurities in {sup 225}Ac produced in 40-200 MeV proton irradiations of thorium

    Energy Technology Data Exchange (ETDEWEB)

    Engle, Jonathan W.; Ballard, Beau D. [Los Alamos National Laboratory, NM (United States); Weidner, John W. [Air Force Institute of Technology, Wright Patterson Air Force Base, OH (United States); and others

    2014-10-01

    Accelerator production of {sup 225}Ac addresses the global supply deficiency currently inhibiting clinical trials from establishing {sup 225}Ac's therapeutic utility, provided that the accelerator product is of sufficient radionuclidic purity for patient use. Two proton activation experiments utilizing the stacked foil technique between 40 and 200 MeV were employed to study the likely co-formation of radionuclides expected to be especially challenging to separate from {sup 225}Ac. Foils were assayed by nondestructive γ-spectroscopy and by α-spectroscopy of chemically processed target material. Nuclear formation cross sections for the radionuclides {sup 226}Ac and {sup 227}Ac as well as lower lanthanide radioisotopes {sup 139}Ce, {sup 141}Ce, {sup 143}Ce, and {sup 140}La whose elemental ionic radii closely match that of actinium were measured and are reported. The predictions of the latest MCNP6 event generators are compared with measured data, as they permit estimation of the formation rates of other radionuclides whose decay emissions are not clearly discerned in the complex spectra collected from {sup 232}Th(p,x) fission product mixtures. (orig.)

  15. Pulse-shape discrimination and energy quenching of alpha particles in Cs$_2$LiLaBr$_6$:Ce$^{3+}$

    CERN Document Server

    Mesick, Katherine E; Stonehill, Laura C

    2016-01-01

    Cs$_2$LiLaBr$_6$:Ce$^{3+}$ (CLLB) is an elpasolite scintillator that offers excellent linearity and gamma-ray energy resolution and sensitivity to thermal neutrons with the ability to perform pulse-shape discrimination (PSD) to distinguish gammas and neutrons. Our investigation of CLLB has indicated the presence of intrinsic radioactive alpha background that we have determined to be from actinium contamination of the lanthanum component. We measured the pulse shapes for gamma, thermal neutron, and alpha events and determined that PSD can be performed to separate the alpha background with a moderate figure of merit of 0.98. We also measured the electron-equivalent-energy of the alpha particles in CLLB and simulated the intrinsic alpha background from $^{227}$Ac to determine the quenching factor of the alphas. A linear quenching relationship $L_{\\alpha} = E_{\\alpha} \\times q + L_0$ was found at alpha particle energies above 5 MeV, with a quenching factor $q = 0.71$ MeVee/MeV and an offset $L_0 = - 1.19$ MeVee.

  16. Development of an Ultra-Low Background Liquid Scintillation Counter for Trace Level Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Erchinger, Jennifer L.; Orrell, John L.; Aalseth, Craig E.; Bernacki, Bruce E.; Douglas, Matthew; Finn, Erin C.; Fuller, Erin S.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Panisko, Mark E.; Shaff, Sarah M.; Warren, Glen A.; Wright, Michael E.

    2015-09-01

    Low-level liquid scintillation counting (LSC) has been established as one of the radiation detection techniques useful in elucidating environmental processes and environmental monitoring around nuclear facilities. The Ultra-Low Background Liquid Scintillation Counter (ULB-LSC) under construction in the Shallow Underground Laboratory at Pacific Northwest National Laboratory aims to further reduce the MDAs and/or required sample processing. Through layers of passive shielding in conjunction with an active veto and 30 meters water equivalent overburden, the background reduction is expected to be 10 to 100 times below typical analytic low-background liquid scintillation systems. Simulations have shown an expected background of around 14 counts per day. A novel approach to the light collection will use a coated hollow light guide cut into the inner copper shielding. Demonstration LSC measurements will show low-energy detection, spectral deconvolution, and alpha/beta discrimination capabilities, from trials with standards of tritium, strontium-90, and actinium-227, respectively. An overview of the system design and expected demonstration measurements will emphasize the potential applications of the ULB-LSC in environmental monitoring for treaty verification, reach-back sample analysis, and facility inspections.

  17. 48 CFR 52.227-11 - Patent Rights-Ownership by the Contractor.

    Science.gov (United States)

    2010-10-01

    ... inventions for the support of scientific research or education; and (4) Make efforts that are reasonable... paragraph (k), in all subcontracts for experimental, developmental, or research work to be performed by a... subcontracts for experimental, developmental, or research work the substance of the patent rights...

  18. 7 CFR Appendix to Part 227 - Apportionment of Funds for Nutrition Education and Training

    Science.gov (United States)

    2010-01-01

    ... NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING... Pursuant to sections 19(j) of the Child Nutrition Act of 1966, as amended (42 U.S.C. 1788), funds available... 7 Agriculture 4 2010-01-01 2010-01-01 false Apportionment of Funds for Nutrition Education...

  19. 7 CFR 227.37 - State plan for nutrition education and training.

    Science.gov (United States)

    2010-01-01

    ... NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING...) nutrition education of children, (iii) inservice training in nutrition education for teachers; (3) Goals and... advice and recommendations of the National Advisory Council on Child Nutrition, State educational...

  20. Latino Parent Agency within the Restrictionist Language Policy Environment of California's Proposition 227

    Science.gov (United States)

    Farruggio, Peter

    2010-01-01

    CThe article is a study of Latino immigrant parents' agency toward primary language (L1) instruction in the face of restrictionist language policy. Certain attitudes and characteristics were associated with advocacy for Spanish L1 instruction. Interviews conducted in an urban California school district among parents with different background…

  1. 48 CFR 252.227-7013 - Rights in technical data-Noncommercial items.

    Science.gov (United States)

    2010-10-01

    ... cooperative agreements with international or multi-national defense organizations, or sales or transfers by... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT... government contract, or any combination thereof. (i) Private expense determinations should be made at...

  2. 48 CFR 952.227-11 - Patent rights-retention by the contractor (short form).

    Science.gov (United States)

    2010-10-01

    ... permitted by law or Government regulations, available to the public on reasonable terms. (5) Small business firm means a small business concern as defined at section 2 of Public Law 85-536 (15 U.S.C. 632) and... DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions...

  3. 30 CFR 250.227 - What environmental impact analysis (EIA) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... (including major sources of supplies, services, energy, and water), land use, subsistence resources and..., but not limited to, those from noise, vessel collisions, and marine trash and debris) that...

  4. Erostratus Unbound: Norway’s 22/7 Converging Frames of War

    DEFF Research Database (Denmark)

    Meret, Susi; Hervik, Peter

    2013-01-01

    The purpose of this introductory article is to set the stage for the theme issue on the 22 July 2011 terror attacks in Oslo and Utøya by mass murderer, Anders Behring Breivik. The article opens up with the historical and literary figure Erostratus to discuss the differences and similarities betwe...

  5. 21 CFR 1.227 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-04-01

    ...)). (8) Packaging (when used as a verb) means placing food into a container that directly contacts the... not physically present. (i) The U.S. agent acts as a communications link between FDA and the foreign facility for both emergency and routine communications. The U.S. agent will be the person FDA contacts...

  6. 48 CFR 227.7103-14 - Conformity, acceptance, and warranty of technical data.

    Science.gov (United States)

    2010-10-01

    ... requirements of the contract pertaining to the delivery of technical data. (b) Conformity and acceptance. (1... a contract clause providing for inspection and acceptance of deliverables and remedies for... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Conformity,...

  7. Erostratus Unbound: Norway’s 22/7 Converging Frames of War

    OpenAIRE

    Meret, Susi; Hervik, Peter

    2013-01-01

    The purpose of this introductory article is to set the stage for the theme issue on the 22 July 2011 terror attacks in Oslo and Utøya by mass murderer, Anders Behring Breivik. The article opens up with the historical and literary figure Erostratus to discuss the differences and similarities between this lone wolf character and the acts of terrorist Anders Behring Breivik. It then situates Breivik firmly within an ideological landscape where communities of politicians, pundits and others dista...

  8. 30 CFR 227.1 - What is the purpose of this part?

    Science.gov (United States)

    2010-07-01

    ... 205 of the Federal Oil and Gas Royalty Management Act of 1982 (the Act), 30 U.S.C. 1735, as amended by the Federal Oil and Gas Royalty Simplification and Fairness Act of 1996, Pub. L. 104-185, August 13... investigation functions to States under Pub. L. 102-154 for solid mineral leases, geothermal leases and...

  9. 227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?

    Science.gov (United States)

    Meringer, Markus; Goodwin, Jay

    2015-01-01

    Abstract Ribonucleic acid (RNA) is one of the two nucleic acids used by extant biochemistry and plays a central role as the intermediary carrier of genetic information in transcription and translation. If RNA was involved in the origin of life, it should have a facile prebiotic synthesis. A wide variety of such syntheses have been explored. However, to date no one-pot reaction has been shown capable of yielding RNA monomers from likely prebiotically abundant starting materials, though this does not rule out the possibility that simpler, more easily prebiotically accessible nucleic acids may have preceded RNA. Given structural constraints, such as the ability to form complementary base pairs and a linear covalent polymer, a variety of structural isomers of RNA could potentially function as genetic platforms. By using structure-generation software, all the potential structural isomers of the ribosides (BC5H9O4, where B is nucleobase), as well as a set of simpler minimal analogues derived from them, that can potentially serve as monomeric building blocks of nucleic acid–like molecules are enumerated. Molecules are selected based on their likely stability under biochemically relevant conditions (e.g., moderate pH and temperature) and the presence of at least two functional groups allowing the monomers to be incorporated into linear polymers. The resulting structures are then evaluated by using molecular descriptors typically applied in quantitative structure–property relationship (QSPR) studies and predicted physicochemical properties. Several databases have been queried to determine whether any of the computed isomers had been synthesized previously. Very few of the molecules that emerge from this structure set have been previously described. We conclude that ribonucleosides may have competed with a multitude of alternative structures whose potential proto-biochemical roles and abiotic syntheses remain to be explored. Key Words: Evolution—Chemical evolution—Exobiology—Prebiotic chemistry—RNA world. Astrobiology 15, 538–558. PMID:26200431

  10. 227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?

    OpenAIRE

    Cleaves, H. James; Meringer, Markus; Goodwin, Jay T.

    2015-01-01

    Abstract Ribonucleic acid (RNA) is one of the two nucleic acids used by extant biochemistry and plays a central role as the intermediary carrier of genetic information in transcription and translation. If RNA was involved in the origin of life, it should have a facile prebiotic synthesis. A wide variety of such syntheses have been explored. However, to date no one-pot reaction has been shown capable of yielding RNA monomers from likely prebiotically abundant starting materials, though this do...

  11. 48 CFR 52.227-14 - Rights in Data-General.

    Science.gov (United States)

    2010-10-01

    ... listings, design details, algorithms, processes, flow charts, formulas, and related material that would... requirements but specifically excludes the source code, algorithms, processes, formulas, and flow charts of...

  12. 48 CFR 52.227-20 - Rights in Data-SBIR Program.

    Science.gov (United States)

    2010-10-01

    ..., algorithms, processes, flow charts, formulas, and related material that would enable the computer program to... code, algorithms, processes, formulas, and flow charts of the software. Limited rights data means...

  13. 48 CFR 252.227-7038 - Patent Rights-Ownership by the Contractor (Large Business).

    Science.gov (United States)

    2010-10-01

    ... corporate structure of which the Contractor is a part; (B) Includes the right to grant sublicenses to the... Contractor made in the performance of work under this contract. (b) Contractor's rights—(1) Ownership. The... subject invention pursuant to an application for an exclusive license submitted in accordance with 37...

  14. 40 CFR 227.6 - Constituents prohibited as other than trace contaminants.

    Science.gov (United States)

    2010-07-01

    ...; (3) Cadmium and cadmium compounds; (4) Oil of any kind or in any form, including but not limited to petroleum, oil sludge, oil refuse, crude oil, fuel oil, heavy diesel oil, lubricating oils, hydraulic fluids... degradation in the sea; provided they will not make edible marine organisms unpalatable; or will not...

  15. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  16. Characterisation of the physico-chemical and solid-state behaviour of drugs in HFA-134 and 227

    OpenAIRE

    Bouhroum, Abdennour

    2011-01-01

    Most drugs have a considerably low solubility in the environmentally friendly hydrofluoroalkane propellants (HFAs) currently used in pressurized metered dose inhalers (pMDIs). As a consequence, instability can occur from crystal growth and Ostwald ripening of the system altering the therapeutic performance of the pMDI. Understanding and being able to predict the behaviour of such drugs in the propellant will help in selecting the correct co-solvents and/or surfactants to increase the stabilit...

  17. [Nebraska 4-H Wheat Science School Enrichment Project, Teacher/Leader Guides 213-222 and 227.

    Science.gov (United States)

    Nebraska Univ., Lincoln. Inst. of Agriculture and Natural Resources.

    Through the 4-H Wheat Science project, students learn the importance of wheat from the complete process of growing wheat to the final product of bread. The curriculum is designed to include hands-on experiences in science, consumer education, nutrition, production economics, vocabulary, and applied mathematics. Teachers can select those units out…

  18. 48 CFR 952.227-14 - Rights in data-general. (DOE coverage-alternates VI and VII)

    Science.gov (United States)

    2010-10-01

    ... CFR 927.404(m) make the change described in Alternate VII to limit the contractor's use of DOE restricted data. Insert the parenthetical phrase “(except Restricted Data in category C-24, 10 CFR part 725... (FEB 1998) As prescribed at 48 CFR 927.404(l) insert Alternate VI to require the contractor to...

  19. 40 CFR 745.227 - Work practice standards for conducting lead-based paint activities: target housing and child...

    Science.gov (United States)

    2010-07-01

    ... control data and, if used, the serial number of any x-ray fluorescence (XRF) device. (ix) Specific... that may cause lead-based paint exposure to one or more children age 6 years and under shall be... exposure to one or more children age 6 years and under shall be collected. (4) The following surfaces...

  20. 49 CFR 173.227 - Materials poisonous by inhalation, Division 6.1, Packing Group I, Hazard Zone B.

    Science.gov (United States)

    2010-10-01

    ... inner packaging on all sides. (5) Prior to reuse, all authorized inner drums must be leakproofness... MATERIALS REGULATIONS SHIPPERS-GENERAL REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Non-bulk Packaging for... a single packaging intended to contain solids or liquids at a mass corresponding to the mass of...

  1. Specific MAP-kinase blockade protects against renal damage in homozygous TGR(mRen2)27 rats

    NARCIS (Netherlands)

    de Borst, MH; Navis, G; de Boer, RA; Vis, LM; van Gilst, WH; van Goor, H

    2003-01-01

    Angiotensin II (AngII) plays an important role in renal damage by acting on hemodynamics, cell-growth, proliferation, and fibrosis, mainly by effects on the AngII type 1 (AT,) receptor. The AT, receptor activates several intracellular signaling molecules such as mitogen-activated protein kinases ext

  2. P2-27: Electrophysiological Correlates of Conscious and Unconscious Processing of Emotional Faces in Individuals with High and Low Autistic Traits

    Directory of Open Access Journals (Sweden)

    Svjetlana Vukusic

    2012-10-01

    Full Text Available LeDoux (1996 The Emotional Brain has suggested that subconsciouss presentation of fearful emotional information is relayed to the amygdala along a rapid subcortical route. Rapid emotion processing is important because it alerts other parts of brain to emotionally salient information. It also produces immediate reflexive responses to threating stimuli in comparison to slower conscious appraisal, which is of important adaptive survival value. Current theoretical models of autism spectrum disorders (ASD have linked impairments in the processing of emotional information to amygdala dysfunction. It can be suggested that impairment in face processing found in autism may be the result of impaired rapid subconscious processing of emotional information which does not make faces socially salient. Previous studies examined subconscious processing of emotional stimuli with backward masking paradigms by using very brief presentation of emotional face stimuli proceeded by a mask. We used an event-related potential (ERP study within a backward masking paradigm with subjects with low and high autistic tendencies as measured by the Autism Spectrum Quotient (AQ questionnaire. The time course of processing of fearful and happy facial expressions and an emotionally neutral face was investigated during subliminal (16 ms and supraliminal (166 ms stimuli presentation. The task consisted of an explicit categorization of emotional and neutral faces. We looked at ERP components N2, P3a, and also N170 for differences between subjects with low ( 19 AQ.

  3. Mouton Jean-Michel édit., Le Sinaï de la conquête arabe à nos jours, Le Caire, IFAO 870, 2001, 227 p.

    Directory of Open Access Journals (Sweden)

    Thierry Bianquis

    2011-12-01

    Full Text Available Contributions : Katia Cytryn-Siverman, The settlement in Northern Sinai in Islamic period. Pascal Ballet, Un atelier de potiers aux « sources de Moïse » (‘Uyûn Mûsâ. Sâmî Sâlih ‘Abd al-Malik, Une inscription du sultan mamelouk Kitbuga découverte à al-Qurrays. Béatrice Dansette, Le Sinaï, lieu de solitude, centre de relations et d’échanges spirituels ? Essai d’interprétation des récits de pèlerins occidentaux au Sinaï aux derniers siècles du Moyen-Âge. Deltev Kraack, Chivalrous adventures...

  4. Ref: Changing river courses in the western part of the Ganga-Brahmaputra delta by Kalyan Rudra (2014), Geomorphology, 227, 87-100

    Science.gov (United States)

    Rudra, Kalyan

    2015-12-01

    Research on river dynamics of the GB delta is in the early stages, and it is a topic of multidisciplinary interest. A narrow sectoral approach of research may lead to much confusion. The 'discussion' has a declared vision of offering corrected information against inconsistencies, improper understanding, and misrepresentation of facts in my paper. But in reality, the critics' arguments are based on the wrong premise, and those may create much confusion. This reply is designed sequentially to address issues raised in the 'discussion'.

  5. Geta burðardýr verið fórnarlömb mansals skv. skilgreiningu 227. gr. a almennra hegningarlaga?

    OpenAIRE

    Eyrún Halla Eyjólfsdóttir 1976

    2014-01-01

    Efni þessarar ritgerðar lýtur að málefnum svokallaðra „burðardýra“ í fíkniefnamálum. Þessi málaflokkur hefur lítið verið rannsakaður en þekkt er að burðardýr hafa orðið fyrir þvingunum og nauðung innan fíkniefnaheimsins. Þessi heimur er eins og gefur að skilja lítt kunnur þar sem hann starfar utan laga og réttar og er lítið vitað um stöðu þessara einstaklinga. Staða þeirra er þó afar erfið vegna ólögmætis starfs þeirra. Þeir standa utan réttarkerfisins og njóta ekki verndar yfirvalda. Dómu...

  6. Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27

    NARCIS (Netherlands)

    de Boer, RA; Pokharel, S; Flesch, M; van Kampen, DA; Suurmeijer, AJH; Boomsma, F; van Gilst, WH; van Veldhuisen, DJ; Pinto, YM

    2004-01-01

    Angiotensin (Ang) II is a key player in left ventricular (LV) remodeling and cardiac fibrosis. Its effects are thought to be transferred at least in part by mitogen-activated protein kinases (MAPK), transforming growth factor (TGF) beta(1), and the Smad pathway. In this study we sought to elucidate

  7. Retraction notice to: Artificial intelligence in pharmaceutical product formulation: Neural computing [Chem. Ind. Chem. Eng. Q. 15(4 (2009 227-236

    Directory of Open Access Journals (Sweden)

    Ibrić Svetlana

    2011-01-01

    Full Text Available This article has been retracted at the request of the authors. The retraction has been made because the authors admitted that they took the text and rawings from the review article written by R. Rowe and E. Colbourn, Future Medicinal Chemistry 1(4 (2009 713-726, without their permission and even did not include this article in the list of references. One of the conditions of submission of a paper for publication are that authors confirm that their work is entirely originally written, someone else’s data and/or text are appropriately cited or quoted and permission has been obtained for use of copyrighted material from other sources. Therefore, the retracted article represents a severe improperly usage of the scientific publishing system. Apologies are offered to readers of the Chem. Ind. Chem. Eng. Q. that this abuse was not detected during the submission process.

    Link to the retracted article 10.2298/CICEQ0904227I

  8. I. The metabolic properties of plutonium and allied materials

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  9. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  10. Estimates of tidal mixing in the Indonesian archipelago from multidisciplinary INDOMIX in-situ data

    Science.gov (United States)

    Koch-Larrouy, Ariane; Atmadipoera, Agus; van Beek, Pieter; Madec, Gurvan; Aucan, Jérôme; Lyard, Florent; Grelet, Jacques; Souhaut, Marc

    2015-12-01

    The Indonesian Mixing program (INDOMIX) was designed to quantify the very strong mixing that transforms Pacific waters into isohaline Indonesian Waters in the Indonesian archipelago. The turbulent dissipation rates and associated mixing were estimated and analyzed using a multidisciplinary approach that combines physical and geochemical in-situ observations: (1) direct measurements of the dissipation using a microstructure profiler, (2) use of density-based fine-scale methods applied to CTD and XCTD data, and (3) study of the vertical distribution of natural radionuclides (radium isotopes and actinium-227). Data were collected at five contrasting stations within the Indonesian archipelago, found above energetic straits or in relatively quiescent large basins. Strong instabilities, inversions of the density profiles and a very strong water mass transformation were observed. A wide range of dissipation values were obtained (between [10-10, 10-4] W kg-1) with spots of higher dissipation in the ocean interior correlated with a strong internal tide signal. Both the fine-scale and micro-scale methods allow us to identify very strong energy dissipation levels above the straits, ranging between [10-7, 10-4] W kg-1, in contrast to lower values at stations further away from the generation sites. The dissipation for the station located in the center of the Halmahera Sea ([10-9, 10-8] W kg-1) is stronger than for the Banda station ([10-11, 10-10] W kg-1), which is even further away from the generation sites. The three approaches agree relatively well and provide vertical eddy diffusivities values ranging between 5×10-4 and 5×10-1 m2 s-1, except in the Banda Sea where values are similar to the ones found in the open ocean (10-6 m2 s-1). CTD and XCTD profilers (deployed between stations) give estimates of dissipation all along the transit. It is found that enhanced mixing occurs preferentially above rough topography, such as in the Ombai Strait, the Halmahera Sea's northern

  11. Negociações Multilaterais do Comércio de Serviços, Intervenção Estatal Brasileira e Defesa dos Interesses Nacionais - 10.5102/uri.v4i2.227

    Directory of Open Access Journals (Sweden)

    Fátima Faro

    2007-10-01

    Full Text Available The purpose of this article is to discuss the evolution of the multilateral negotiations focused on trade of services, as well as the Brazilian governmental politics to emphasize the development of this economic activity, and to support our participation within the bilateral and multilateral rounds of negotiation, from an individual country perspective, according to the national point of view.

  12. Niskin Bottle Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT218-227 during 2010 (NCEI Accession 0087596)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  13. Water Column Chemical Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT199-227 during 2008-2010 (NCEI Accession 0088839)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  14. Multibeam collection for TN227: Multibeam data collected aboard Thomas G. Thompson from 2008-11-13 to 2008-11-28, departing from Apia, Western Samoa and returning to Apia, Western Samoa

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  15. Crystal structure and absolute configuration of (3aS,4S,5R,7aR-2,2,7-trimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxole-4,5-diol

    Directory of Open Access Journals (Sweden)

    Mario A. Macías

    2015-09-01

    Full Text Available The absolute configuration of the title compound, C10H16O4, determined as 3aS,4S,5R,7aR on the basis of the synthetic pathway, was confirmed by X-ray diffraction. The molecule contains a five- and a six-membered ring that adopt twisted and envelope conformations, respectively. The dihedral angle between the mean planes of the rings is 76.80 (11° as a result of their cis-fusion. In the crystal, molecules are linked by two pairs of O—H...O hydrogen bonds, forming chains along [010]. These chains are further connected by weaker C—H...O interactions along [100], creating (001 sheets that interact only by weak van der Waals forces.

  16. The Functional Role of PI3K in Maintenance of Blood Pressure and Baroreflex Suppression in (mRen2)27 and mRen2.Lewis Rat

    OpenAIRE

    Logan, Exazevia M; Aileru, Azeez A; Shaltout, Hossam A.; Averill, David B.; Diz, Debra I.

    2011-01-01

    The phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway in brain of spontaneously hypertensive rats (SHR), but not Wister-Kyoto (WKY) rats, contributes to elevated mean arterial pressure (MAP). The role of PI3K in regulation of blood pressure or autonomic function in the nucleus solitary tract (NTS) is yet to be established in other AngII-dependent models of hypertension. Thus, we microinjected PI3K inhibitors, wortmannin or LY294002, into the NTS, and measured MAP, baroreflex se...

  17. CTD Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT218-227 during 2010) (NCEI Accession 0087584)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  18. Investigation for determining the retention properties of rock over the ASSE II mine for dissolved radionuclides

    International Nuclear Information System (INIS)

    For a model consideration of groundwater movement and the associated transport of dissolved substance in deep groundwater, the retention properties of the ASSE II mine for radionuclides dissolved in water were determined. A series of properties of rocks were examined and described for this purpose. Apart from the chemical, mineralogical and petrophysical characteristics of the rocks, the retention was determined by 3 different methods and stated in the form of distribution coefficients for specific elements. A comparison of the results of vibration and diffusion experiments gave good agreement, while the results in through column experiments only reached the same order of magnitude after an expensive determination with the aid of a place concentration distribution. The distribution coefficients for the elements carbon, selenium, strontium, technetium, iodine, caesium, lead, radium, actinium, proto-actinium, uranium, neptunium, plutonium, americium and curium are listed and collected for model rock packages. (orig./HP)

  19. Sorption studies of radioelements on geological materials

    OpenAIRE

    Berry, J. A; 油井 三和; 北村 暁

    2007-01-01

    Batch sorption experiments have been carried out to study the sorption of uranium, technetium, curium, neptunium, actinium, protactinium, polonium, americium and plutonium onto bentonite, granodiorite and tuff. Mathematical modelling using the HARPHRQ program and the HATCHES database was carried out to predict the speciation of uranium and technetium in the equilibrated seawater, and neptunium, americium and plutonium in the rock equilibrated water. Review of the literature for thermodynamic ...

  20. The discoveries of uranium 237 and symmetric fission — From the archival papers of Nishina and Kimura

    OpenAIRE

    IKEDA, Nagao

    2011-01-01

    Shortly before the Second World War time, Nishina reported on a series of prominent nuclear physical and radiochemical studies in collaboration with Kimura. They artificially produced 231Th, a member of the natural actinium series of nuclides, by bombarding thorium with fast neutrons. This resulted in the discovery of 237U, a new isotope of uranium, by bombarding uranium with fast neutrons, and confirmed that 237U disintegrates into element 93 with a mass number of 237. They also identified t...

  1. System for recovery of daughter isotopes from a source material

    Science.gov (United States)

    Tranter, Troy J [Idaho Falls, ID; Todd, Terry A [Aberdeen, ID; Lewis, Leroy C [Idaho Falls, ID; Henscheid, Joseph P [Idaho Falls, ID

    2009-08-04

    A method of separating isotopes from a mixture containing at least two isotopes in a solution is disclosed. A first isotope is precipitated and is collected from the solution. A daughter isotope is generated and collected from the first isotope. The invention includes a method of producing an actinium-225/bismuth-213 product from a material containing thorium-229 and thorium-232. A solution is formed containing nitric acid and the material containing thorium-229 and thorium-232, and iodate is added to form a thorium iodate precipitate. A supernatant is separated from the thorium iodate precipitate and a second volume of nitric acid is added to the thorium iodate precipitate. The thorium iodate precipitate is stored and a decay product comprising actinium-225 and bismuth-213 is generated in the second volume of nitric acid, which is then separated from the thorium iodate precipitate, filtered, and treated using at least one chromatographic procedure. A system for producing an actinium-225/bismuth-213 product is also disclosed.

  2. 76 FR 11363 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Science.gov (United States)

    2011-03-02

    ... Computer Software and Noncommercial Computer Software Documentation. (3) For Small Business Innovation... (noncommercial technical data), 252.227-7014 (noncommercial software and software documentation), 252.227-7015 (commercial technical data), and 252.227-7018 (Small Business Innovation Research (SBIR)). The exception...

  3. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    P. Bernot

    2005-07-13

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with {sup 231}Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or

  4. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  5. Communication Breakdown: Librarian and Student Approaches to Virtual Reference Differ. A review of: Walter, Virginia A. and Cindy Mediavilla. “Teens Are from Neptune, Librarians Are from Pluto: An Analysis of Online Reference Transactions.” Library Trends 54.2 (2005: 209-227.

    Directory of Open Access Journals (Sweden)

    Stephanie Hall

    2006-09-01

    Full Text Available Objective – To evaluate the effectiveness of an online reference and referral service for students (primarily those in middle school and high school seeking homework help. Design – Analysis of 114 transcripts of reference transactions. Setting – A centralized homework reference and tutor referral service provided on behalf of the California State Library by the Metropolitan Cooperative Library System. Subjects – Virtual reference librarians at a large urban library system and middle and high school students in California. Methods – One hundred fourteen virtual reference transactions recorded between October 12 and November 8, 2003 were evaluated against the Reference and User Services Association’s (RUSA “Guidelines for Behavioral Performance of Reference and Information Service Providers.” Secondly, the transcripts were subjected to discourse analysis. Main results Performance of virtual reference librarians vis‐àvis RUSA guidelines In the majority of cases, there was some evidence that librarians communicated clearly (110 out of 114 transactions. In 78 cases, it appeared that a librarian was available quickly, and in 92 of the transactions a friendly greeting was given. What was striking, however, was that in a clear majority of cases, some of the classic reference interview strategies were not employed. In 100 or more cases each, the following strategies were not observed: repeating or paraphrasing the question; helping to interpret the question; verifying mutual understanding; asking if the question has been answered; asking if the student needs more information. Furthermore, in 75 cases librarians did not probe for further information to clarify the question, while in 87 cases they did not check that information had been clearly understood. Possibly related to these findings, the researchers felt that the transcripts revealed “a conviction that homework questions are not the proper content for reference transactions” (222. In addition, librarians were found to be frequently too quick to refer students to a tutor, when a query might have been better answered as a reference question. Findings of discourse analysis In general, the virtual reference librarians used impersonal, formal language to “reinforce the professional’s superior position vis‐à‐vis the help‐seeker” (217. There were repeated attempts by the students to interject a lighter or warmer tone (using humour, emoticons, informal language, introducing a personal note, etc.. These attempts were rarely reciprocated, with librarians continuing to use impersonal language, including stock messages such as: “we are experiencing a very busy time right now,” (217; or, “I am going to send you a page which will give you some help with your homework. After we disconnect this session, click on this link and follow the instructions to be connected with a tutor. Please do not click on any links on this page until after we have disconnected” (217. In several cases librarians were preoccupied with defining their roles—for example, specifying that they could give reference help but not advice. In all, the distancing mechanisms used by librarians, combined with occasional inaccurate referrals and technical problems with the software, were seen to create an enormous potential forfrustration on the part of the student. Conclusions – The most important implication of the study was that librarians and students were worlds (or planets apart in their approach to the reference interaction. While “teens attempted to create meaningby recreating the chat discourse environment in which they were most at home”, librarians “tried to create meaning in a parallel discourse environment that duplicated as much as possible the standard impersonal protocols of a face‐to‐face reference counter” (223. One suggested way to alleviate the disconnect between librarians and students was to involve students in the planning of the services. For now, however, the authors conclude that “teens are from Neptune, librarians are from Pluto. Better services would result if they could meet somewhere closer together” (224.

  6. Public Libraries in Norway Help Non-Western Immigrant Women to Integrate into Society. A Review of: Audunson, R., Essmat, S., & Aabø, S. (2011. Public libraries: A meeting place for immigrant women? Library & Information Science Research, 33(3, 220-227. doi: 10.1016/j.lisr.2011.01.003

    Directory of Open Access Journals (Sweden)

    Kathryn Oxborrow

    2012-03-01

    Full Text Available Objectives – To discover the ways in which the public library was used by immigrant women, with a particular focus on the library as a meeting place.Design – Semi-structured qualitative interviews conducted in the participants’ native languages.Setting – Public libraries in Norway. Participants lived in one of two cities both with a population of approximately 40,000 and a somewhat lower number of immigrants than the national average.Subjects – Nine non-western women who had immigrated to Norway between 8 months and 17 years prior to the study. Three women were from Iran, Kurdistan and Afghanistan respectively. All identified themselves as public library users.Methods – Participants were interviewed in their native languages and the qualitative results were analyzed in accordance with the theoretical framework set out by the authors. The main areas of focus were the role of the library in the generation of social capital, and the library as a high intensive versus low intensive meeting place.Main Results – Participants used public libraries in various ways. In the initial stages of life in a new country they were used to observe and learn about the majority culture and language. They were also used as a safe place to openly grieve and provide comfort among close friends without fear of being seen by other fellow countrymen. Over time, participants came to use the library space in more traditional ways such as for information, social, and professional needs. The study also revealed that using public libraries built trust in the institution of libraries and librarians as employees.Conclusions – The public library plays a key role in the generation of social capital, both in terms of integrating into the majority culture through observation and spontaneous interactions (bridging social capital and connecting with others from participants’ home cultures (bonding social capital for example through the provision of social space and other links to home such as native language materials. The public library was used initially by participants as a high intensive meeting place, for meeting with friends and consoling one another. In time, however, the public library became a medium- to low-intensive meeting place, with participants engaging in library programmes or in spontaneous interactions with other library customers. Moreover, the study refutes the Swedish Library Association’s conclusion that library is used more often by immigrants that have lived in the country for long periods of time.

  7. ‘A dialogue about the art of portraiture’ Originally published as ‘Gespräch von der Bildniskunst’, Österreichische Rundschau, Volume 6, 1906, 502—516, and republished: Julius Schlosser, Präludien Vorträge und Aufsätze, Berlin: Bard 1927, 227—247. Translated with an introduction by Karl Johns

    OpenAIRE

    Julius Schlosser

    2011-01-01

    In an unusually popular and readable dialogue form, Schlosser alludes to the classical education he takes for granted in any reader approaching his favourite ‘thorny’ questions from aesthetics and history. These involve the problems of naturalism, impressionism, portrait likeness, psychology of perception and numerous others being bandied around academic circles at the turn of the century. It is of further interest in directly referring critically to his recently deceased friend (Alois Riegl)...

  8. Low background counting of 222Rn, 220Rn and 219Rn with electrostatic counters

    Science.gov (United States)

    Mong, Brian; EXO-200 Collaboration; nEXO Collaboration

    2014-09-01

    The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. Supported by NSERC Project Grants ``Search for Double Beta Decay with EXO.''

  9. Purification of cerium, neodymium and gadolinium for low background experiments

    Science.gov (United States)

    Boiko, R. S.; Barabash, A. S.; Belli, P.; Bernabei, R.; Cappella, F.; Cerulli, R.; Danevich, F. A.; Incicchitti, A.; Laubenstein, M.; Mokina, V. M.; Nisi, S.; Poda, D. V.; Polischuk, O. G.; Tretyak, V. I.

    2014-01-01

    Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search), 136Ce (2β+ candidate with one of the highest Q2β). The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides) was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  10. Mixed valency of the RE and Ac ions in solid states

    International Nuclear Information System (INIS)

    Full text: This review is devoted to consideration of the methods and results of the theoretical and experimental investigations of the electronic state of the rare earths and actinium ions in the separate compound. The methods of the high resolution X ray spectroscopy were used for our consideration. Energy of the X ray lines of the rare earths and actinium ions in free state and solid states was study carefully. Valency shifts of X Ray lines under change of electronic state of nf - ions in different oxide, fluoride and chloride compounds were determined for K -, L- and M - lines for these ions with accuracy near 10 -100 MeV. We studied the electronic state of nf- ions which is changed from '+2' to '+4' and determined the concentration of ions in different electronic state. Relative error for theoretical energy of the most lines for HFP - approach in comparison with experiment is less than 0.5%, and deviation for concentration is less than 5%

  11. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Directory of Open Access Journals (Sweden)

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  12. A study of uranium and thorium migration at the Koongarra uranium deposit with application to actinide transport from nuclear waste repositories

    International Nuclear Information System (INIS)

    One way to gain confidence in modelling possible radionuclide releases is to study natural systems which are similar to components of the multibarrier waste repository. Several such analogues are currently under study and these provide useful data about radionuclide behaviour in the natural environment. One such system is the Koongarra uranium deposit in the Northern Territory. In this dissertation, the migration of actinides, primarily uranium and thorium, has been studied as an analogue for the behaviour of transuranics in the far-field of a waste repository. The major findings of this study are: 1. the main process retarding uranium migration in the dispersion fan at Koongarra is sorption, which suppresses dissolved uranium concentrations well below solubility limits, with ferrihydrite being a major sorbing phase; 2. thorium is extremely immobile, with very low dissolved concentrations and corresponding high distribution ratios for 230Th. Overall, it is estimated that colloids are relatively unimportant in Koongarra groundwater. Uranium migrates mostly as dissolved species, whereas thorium and actinium are mostly adsorbed to larger, relatively immobile particles and the stationary phase. However, of the small amount of 230Th that passes through a 1μm filter, a significant proportion is associated with colloidal particles. Actinium appears to be slightly more mobile than thorium and is associated with colloids to a greater extent, although generally present in low concentrations. These results support the possibility of colloidal transport of trivalent and tetravalent actinides in the vicinity of a nuclear waste repository. 112 refs., 23 tabs., 32 figs

  13. Purification of cerium, neodymium and gadolinium for low background experiments

    Directory of Open Access Journals (Sweden)

    Boiko R.S.

    2014-01-01

    Full Text Available Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search, 136Ce (2β+ candidate with one of the highest Q2β. The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  14. The Knossos Od Series. An Epigraphical Study

    DEFF Research Database (Denmark)

    Nosch, Marie-Louise Bech

    and decoration of the cloth. Moreover, scribe 227, newly identified by KILLEN and MELENA, is presented. Scribe 227 records small amounts of wool, writes in a style similar to the writing of scribes 113 and 115, and is associated with the area I1 near the North Entrance. His administrative practices thus seem...

  15. 21 CFR 520.534 - Decoquinate.

    Science.gov (United States)

    2010-04-01

    ...—(1) Amount. Feed 22.7 milligrams per 100 pounds of body weight (0.5 milligram per kilogram) per day... rate of 22.7 milligrams per 100 pounds body weight daily (0.5 milligram per kilogram) for at least...

  16. 32 CFR 286.12 - Exemptions.

    Science.gov (United States)

    2010-07-01

    ... 48 CFR, Subpart 227.71-227.72. Technical data developed exclusively with Federal funds may be... requester as to provide no new substantive information. (4) A direction or order from a superior to a... members. In such situations, balance the surviving family members' privacy against the public's right...

  17. 32 CFR 701.59 - A brief explanation of the meaning and scope of the nine FOIA exemptions.

    Science.gov (United States)

    2010-07-01

    ...), chapter 2 of 48 CFR, subparts 227.71 and 227.72. Technical data developed exclusively with Federal funds... superior to a subordinate, though contained in an internal communication, generally cannot be withheld from... members. In such situations, balance the surviving family members' privacy against the public's right...

  18. 48 CFR 212.7003 - Technical data and computer software.

    Science.gov (United States)

    2010-10-01

    ... computer software. 212.7003 Section 212.7003 Federal Acquisition Regulations System DEFENSE ACQUISITION... data and computer software. For purposes of establishing delivery requirements and license rights for technical data under 227.7102 and for computer software under 227.7202, there shall be a...

  19. AcEST: BP919927 [AcEST

    Lifescience Database Archive (English)

    Full Text Available tr|B7S227|B7S227_9GAMM Molybdate ABC transporter, periplasmic mo... 33 7.2 >tr|A9... OS=Trichomonas vagina... 33 5.5 tr|B4JN38|B4JN38_DROGR GH24212 OS=Drosophila grimshawi GN=GH2421... 33 7.2

  20. bu ke kao xu shu zhe zhi zai shen shi (不可靠叙述者之再审视)

    DEFF Research Database (Denmark)

    Hansen, Per Krogh

    2008-01-01

    Kinesisk oversættelse af "Reconsidering the Unreliable Narrator" in Semiotica 165 - 1/4 2007: 227-246. Oversætter: Shang Biwu.......Kinesisk oversættelse af "Reconsidering the Unreliable Narrator" in Semiotica 165 - 1/4 2007: 227-246. Oversætter: Shang Biwu....

  1. 78 FR 979 - Petition for Exemption; Summary of Petition Received

    Science.gov (United States)

    2013-01-07

    ... (65 FR 19477-78). Docket: To read background documents or comments received, go to http://www..., Transport Airplane Directorate, Federal Aviation Administration, 1601 Lind Avenue SW., Renton, WA 98057-3356; email theresa.j.white@FAA.gov ; (425) 227-2956; fax: 425-227-1320; Andrea Copeland, ARM-208, Office...

  2. 77 FR 7604 - Notice Requesting Public Comment on Two Proposed Unemployment Insurance (UI) Program Performance...

    Science.gov (United States)

    2012-02-13

    ... Spisak, U.S. Department of Labor, ETA/Office of Unemployment Insurance, 200 Constitution Avenue NW., Room... issued a ``call to action'' in Unemployment Insurance Program Letter (UIPL) No. 19-11 to ensure that UI... be based on the ETA 227 and ETA 227 EUC data for the CY. Per the Unemployment Insurance...

  3. Drug: D08348 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08348 Drug Phendimetrazine hydrochloride; Antapentan (TN) C12H17NO. HCl 227.1077 227.7304 D08348.gif Anorex...ic; Psychostimulant CAS: 7635-51-0 PubChem: 96025035 LigandBox: D08348 ATOM 15 1 C1

  4. 77 FR 12175 - Airworthiness Directives; DASSAULT AVIATION Airplanes

    Science.gov (United States)

    2012-02-29

    ... AD to prevent cracking of the flap tracks, which could lead to flap asymmetry and loss of control of..., 1200 New Jersey Avenue SE., Washington, DC. FOR FURTHER INFORMATION CONTACT: Tom Rodriguez, Aerospace..., Washington 98057-3356; telephone (425) 227-1137; fax (425) 227-1149. SUPPLEMENTARY INFORMATION: Discussion...

  5. Dicty_cDB: [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFC227 (Link to dictyBase) - - - Contig-U16444-1 VFC227Z (Link... to Original site) - - VFC227Z 622 - - - - Show VFC227 Library VF (Link to library) Clone ID VFC227 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16444-1 Original site URL http://dict...y vs DNA Score E Sequences producing significant alignments: (bits) Value N AC116978 |AC116978.1 Dictyosteli...um discoideum chromosome 2 map 4846697-4874480 strain AX4, *** SEQUENCING IN PROGRESS ***. 876 0.0 5 AC117076 |AC117076.2 Dict

  6. Monte Carlo Simulations of Necrotic Cell Targeted Alpha Therapy

    International Nuclear Information System (INIS)

    Full text: Hypoxic tumour cells are radioresistant and are significant contributors to the locoregional recurrences and distant metastases that mark treatment failure. Due to restricted circulatory supply, hypoxic tumor cells frequently become necrotic and thus necrotic areas often lie near hypoxic tumour areas. In this study we investigate the feasibility of binding an alpha-emitting conjugate to necrotic cells located in the proximity of hypoxic, viable tumour cells. Monte Carlo radiation transport simulations were performed to investigate the dose distribution resulting from the thorium 227 (Th227) decay chain in a representative tumour geometry. The Geant4 software toolkit was used to simulate the decay and interactions of the Th227 decay chain. The distribution of Th227 was based on a study by Thomlinson and Gray of human lung cancer histological samples (Thomlinson RH, Gray LH. Br J Cancer 1955; 9:539). The normalized dose distribution obtained with Geant4 from a cylindrical Th227 source in water is illustrated in Fig. I. The relative contribution of the different decay channels is displayed, together with a profile through the centre of the accumulated dose map. The results support the hypothesis that significant α-particle doses will be deposited in the hypoxic tumor tissue immediately surrounding the necrotic core (where the majority of Th227 will be located). As an internal a-particle generator, the Th227-radioimmunoconjugate shows potential as an efficient hypoxic tumour sterilizer.

  7. Radionuclide interactions with marine sediments

    International Nuclear Information System (INIS)

    A critical review of the literature on the subject of the interactions of radionuclides with marine sediments has been carried out. On the basis of the information available, an attempt has been made to give ranges and 'best estimates' for the distribution ratios between seawater and sediments. These estimates have been based on an understanding of the sediment seawater system and the porewater chemistry and mineralogy. Field measurements, laboratory measurements and estimates based on stable-element geochemical data are all taken into account. Laboratory measurements include distribution-ratio and diffusion-coefficient determinations. The elements reviewed are carbon, chlorine, calcium, nickel, selenium, strontium, zirconium, niobium, technetium, tin, iodine, caesium, lead, radium, actinium, thorium, protactinium, uranium, neptunium, plutonium, americium and curium. (author)

  8. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  9. Proposed training program for construction personnel involved in remedial action work at sites contaminated by naturally occurring radionuclides

    International Nuclear Information System (INIS)

    Many sites used during the early days of the US atomic energy program are contaminated with radionuclides of the primordial decay chains (uranium, thorium, and actinium series). This contamination consists of residues resulting from refining and processing uranium and thorium. Preparation of these sites for release to unrestricted private use will involve the assistance of construction workers, many of whom have limited knowledge of the hazards associated with radioactive materials. Therefore, there is a need to educate these workers in the fundamentals of radioactive material handling to minimize exposures and possible spread of contamination. This training should disseminate relevant information at an appropriate educational level and should instill a cautious, common-sense attitude toward the handling of radioactive materials. The training should emphasize basic information concerning environmental radiation within a context of relative risk. A multi-media format, including colorful visual aids, demonstration, and discussion, should be used to maximize motivation and retention. A detailed, proposed training program design is presented

  10. JAEA thermodynamic database for performance assessment of geological disposal of high-level and TRU wastes. Refinement of thermodynamic data for trivalent actinoids and samarium

    International Nuclear Information System (INIS)

    Within the scope of the JAEA thermodynamic database project for performance assessment of geological disposal of high-level radioactive and TRU wastes, the refinement of the thermodynamic data for the inorganic compounds and complexes of trivalent actinoids (actinium(III), plutonium(III), americium(III) and curium(III)) and samarium(III) was carried out. Refinement of thermodynamic data for these elements was based on the thermodynamic database for americium published by the Nuclear Energy Agency in the Organisation for Economic Co-operation and Development (OECD/NEA). Based on the similarity of chemical properties among trivalent actinoids and samarium, complementary thermodynamic data for their species expected under the geological disposal conditions were selected to complete the thermodynamic data set for the performance assessment of geological disposal of radioactive wastes. (author)

  11. Theoretical Study on Properties of New Isotope 265Bh

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The properties of nuclei belonging to the newly observed α-decay chain starting from 265Bh have been studied. The axially deformed relativistic mean-field calculation with the force NL-Z2 has been performed in the blockedBCS approximation. Some ground state properties such as binding energies, deformations, spins, and parities, as well as Q-values of the α-decay for this decay chain have been calculated and compared with known experimental data. Good agreement is found. The single-particle spectrum of the nucleus 265 Bh is studied and some new magic numbers are found,while the magnitudes of the shell gaps in superheavy nuclei are much smaller than those of nuclei before the actinium region, and the Fermi surfaces are close to the continuum. Thus the superheavy nuclei are usually not stable. The The methods which give good agreement with the data are selected.

  12. Colonization of marine snow aggregates by invertebrate zooplankton : Abundance, scaling, and possible role

    DEFF Research Database (Denmark)

    Kiørboe, Thomas

    2000-01-01

    I compiled literature observations of abundances of invertebrate zooplankters associated with marine snow aggregates in the euphotic zone. Abundances, normalized with ambient concentrations of colonizers, scale with equivalent aggregate radius raised to power 2.27. Different taxonomic groups show...

  13. 78 FR 49370 - Inflation Adjustment of Maximum Forfeiture Penalties

    Science.gov (United States)

    2013-08-14

    ... Job Creation Act of 2012, 72 FR 71131, 71134 (November 29, 2012). Accordingly, the only penalties... Records & 9,600/day. Accounts. Sec. 223(b) Dial-a-Porn 80,000/day. ] Sec. 227(e) 10,000/violation....

  14. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available ... 800-227-2345 Home Learn About Cancer Stay Healthy Find Support & Treatment Explore Research Get Involved Find Local ACS Stay Healthy » Tools and Calculators » Videos » Get Tested for Colon ...

  15. Gene : CBRC-HSAP-10-0042 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available tical protein LOC729471 (LOC729471), mRNA /cds=p(1,1227) /gb=XM_001130359 /gi=113416467 /ug=Hs.693254 /len=1...227 2e-20 28% MVTSSLTVAITSLVVVITSLVVIITSFVVVTTSLVVVITSLVVVITSIAIAIATLVVVLTFTVVVLTSLVVVTTSLVMVITPPFAVITS...LGVVITSLVVIITCLVLVITALGVVITSLGVVVTSLVMVITPLVAVITPLGVVITSLVVVITSLVMVITSLTVVITSSIVVITPLVMVITSLTVIITS

  16. 78 FR 9731 - Gulf of Mexico, Outer Continental Shelf (OCS), Central Planning Area (CPA) Oil and Gas Lease Sale...

    Science.gov (United States)

    2013-02-11

    ...: Notice of Availability (NOA) of a Record of Decision (ROD) for CPA Lease Sale 227 in the Gulf of Mexico... Statement (Multisale FEIS). Authority: This NOA is published pursuant to the regulations (40 CFR...

  17. EST Table: FS796464 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to putative lysosomal glucocerebrosidase [Tribolium castaneum] 10/09/09 32 %/334 aa FBpp0237202|DvirGJ227...milar to putative lysosomal glucocerebrosidase [Tribolium castaneum] FS796494 ffbm ...

  18. 76 FR 66754 - Federal Bureau of Prisons

    Science.gov (United States)

    2011-10-27

    ...,227 to 239,344. Of the approximately 29,000 inmates to be added to the Federal prison system during.... That mission is to protect society by confining offenders in the controlled environments of prison...

  19. 77 FR 64837 - Federal Aviation Administration

    Science.gov (United States)

    2012-10-23

    ... Federal Aviation Administration Fourth Meeting: RTCA Special Committee 227, Standards of Navigation Performance AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION... 15, 2012. Kathy Hitt, Management Analyst, Business Operations Group, Federal Aviation...

  20. Caribou survey, southern Alaska Peninsula herd, 14-15 January 1983

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A January 1983 survey observed 5,641 caribou in 227 separate groups. The largest group was a loose assemblage of 420 animals observed between Outer marker and Grant...

  1. InterProScan Result: FS913424 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS913424 FS913424_2_ORF2 176542EC4019F227 PANTHER PTHR11669 REPLICATION FACTOR C / ...03677)|Cellular Component: nucleus (GO:0005634)|Biological Process: DNA replication (GO:0006260) ...

  2. Design, synthesis and characterization of bioinspired nanomaterials for engineering and biomedicine

    OpenAIRE

    Ceylan, Hakan

    2014-01-01

    Ankara : The Materials Science and Nanotechnology Program and the Graduate School of Engineering and Science of Bilkent University, 2014. Thesis (Ph. D.) -- Bilkent University, 2014. Includes bibliographical references leaves 227-247. Ceylan, Hakan Ph. D.

  3. Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma

    DEFF Research Database (Denmark)

    Judson, Ian; Verweij, Jaap; Gelderblom, Hans;

    2014-01-01

    %]), febrile neutropenia (103 (46%) vs 30 [13%]), anaemia (78 [35%] vs 10 [5%]), and thrombocytopenia (75 [33%]) vs one [... response (60 [26%] of 227 patients vs 31 [14%] of 228; pneutropenia (93 [42%] vs 83 [37...

  4. [Wilhelm Lenz. Theodor Schiemanns Revaler Jahre (1883-1887)] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2008-01-01

    Arvustus: Wilhelm Lenz. Theodor Schiemanns Revaler Jahre (1883-1887). - Ostseeprovinzen, baltische Staaten und das Nationale. Münster : LIT, 2005. Lk. 227-250. Tallinna linnaarhiivi esimesest linnaarhivaarist

  5. AcEST: DK947480 [AcEST

    Lifescience Database Archive (English)

    Full Text Available NDC80 OS=Cand... 32 2.6 sp|O61308|PUMA_PARUN 227 kDa spindle- and centromere-associated ... 32 3.3 sp|P40460...LVKFQKYVDSMKAKSEEWPIKLSKIEDELNEKKENIKLITEEISQIQDSLQRKGLS 438 Query: 289 EEQ 297 EQ Sbjct: 439 VEQ 441 >sp|O61308|PUMA..._PARUN 227 kDa spindle- and centromere-associated protein OS=Parascaris univalens GN=PUMA

  6. Preparation of porous materials for radionuclides capture

    International Nuclear Information System (INIS)

    Porous materials showing promise for radionuclide capture from water at contaminated sites were prepared. Nanoporous materials (size of pores 1-100 nm) and some polymers are well suited to this purpose owing their affinity for selected radionuclides. Nanoporous metal oxides and silica gel with styrene-divinylbenzene-TODGA-modified surface were prepared, characterized and tested for radionuclide (227Ac, 227Th, 223Ra) capture efficiency. (orig.)

  7. 24 CFR 35.1320 - Lead-based paint inspections, paint testing, risk assessments, lead-hazard screens, and...

    Science.gov (United States)

    2010-04-01

    ... by a State or Tribal program authorized by the EPA under 40 CFR 745.324, or by the EPA at 40 CFR 745... either by a state or tribal program authorized by the EPA, or by the EPA at 40 CFR 745.227(c), (d), and... promulgated by the EPA at 40 CFR 745.227(h) or, if such standards are not in effect, the following levels...

  8. A novel Sarcocystis neurona genotype XIII is associated with severe encephalitis in an unexpectedly broad range of marine mammals from the northeastern Pacific Ocean

    OpenAIRE

    Barbosa, L; Johnson, CK; Lambourn, DM; Gibson, AK; Haman, KH; Huggins, JL; Sweeny, AR; Sundar, N.; Raverty, SA; Grigg, ME.

    2015-01-01

    © 2015 . Sarcocystis neurona is an important cause of protozoal encephalitis among marine mammals in the northeastern Pacific Ocean. To characterise the genetic type of S. neurona in this region, samples from 227 stranded marine mammals, most with clinical or pathological evidence of protozoal disease, were tested for the presence of coccidian parasites using a nested PCR assay. The frequency of S. neurona infection was 60% (136/227) among pinnipeds and cetaceans, including seven marine mamma...

  9. Migration, Career and Educational Strategies of Students in Rural Kazakhstan

    OpenAIRE

    Aygul Kurmangalieva; Galina Abdrakhmanova

    2012-01-01

    Aygul Kurmangaliyeva, Ph.D. in Economics, Director of the Education Development Institute, International Business Academy, Almaty, the Republic of Kazakhstan. Email: Address: 227 Rozybakiyeva St., Almaty, 050060, the Republic of Kazakhstan.Galina Abdrakhmanova, Ph.D. in Economics, Professor at the Finance Chair of the International Business Academy, Almaty, the Republic of Kazakhstan. Email: Address: 227 Rozybakiyeva St., Almaty, 050060, the Republic of Kaza...

  10. Minor Actinide Burning in Thermal Reactors. A Report by the Working Party on Scientific Issues of Reactor Systems

    International Nuclear Information System (INIS)

    The actinides (or actinoids) are those elements in the periodic table from actinium upwards. Uranium (U) and plutonium (Pu) are two of the principal elements in nuclear fuel that could be classed as major actinides. The minor actinides are normally taken to be the triad of neptunium (Np), americium (Am) and curium (Cm). The combined masses of the remaining actinides (i.e. actinium, thorium, protactinium, berkelium, californium, einsteinium and fermium) are small enough to be regarded as very minor trace contaminants in nuclear fuel. Those elements above uranium in the periodic table are known collectively as the transuranics (TRUs). The operation of a nuclear reactor produces large quantities of irradiated fuel (sometimes referred to as spent fuel), which is either stored prior to eventual deep geological disposal or reprocessed to enable actinide recycling. A modern light water reactor (LWR) of 1 GWe capacity will typically discharge about 20-25 tonnes of irradiated fuel per year of operation. About 93-94% of the mass of uranium oxide irradiated fuel is comprised of uranium (mostly 238U), with about 4-5% fission products and ∼1% plutonium. About 0.1-0.2% of the mass is comprised of neptunium, americium and curium. These latter elements accumulate in nuclear fuel because of neutron captures, and they contribute significantly to decay heat loading and neutron output, as well as to the overall radio-toxic hazard of spent fuel. Although the total minor actinide mass is relatively small - approximately 20-25 kg per year from a 1 GWe LWR - it has a disproportionate impact on spent fuel disposal, and thus the longstanding interest in transmuting these actinides either by fission (to fission products) or neutron capture in order to reduce their impact on the back end of the fuel cycle. The combined masses of the trace actinides actinium, thorium, protactinium, berkelium and californium in irradiated LWR fuel are only about 2 parts per billion, which is far too low for

  11. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    International Nuclear Information System (INIS)

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  12. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  13. Octupole Deformed Nuclei in the Actinide Region

    CERN Multimedia

    Thorsteinsen, T; Rubio barroso, B; Simpson, J; Gulda, K; Sanchez-vega, M; Cocks, J; Nybo, K; Garcia borge, M; Aas, A; Fogelberg, B; Honsi, J; Smith, G; Naumann, R; Grant, I

    2002-01-01

    The aim of the present study is to investigate the limits of the "island" of octupole deformation in the mass region A=225. It is of particular importance to demonstrate experimentally the sudden disappearance of the stable octupole deformation in the presence of a well developed quadrupole field. \\\\ \\\\In order to establish the upper border line the $\\beta$ -decay chains of $^{227}$Rn $\\rightarrow ^{227}$Fr $\\rightarrow ^{227}$Ra and $^{231}$Fr $\\rightarrow ^{231}$Ra $\\rightarrow ^{231}$Ac were studied at PSB-ISOLDE using advanced fast timing and $\\gamma$-ray spectroscopy techniques. The lifetimes of the excited states have been measured in the picosecond range using the time-delayed $\\beta\\gamma\\gamma$(t) method.

  14. Dig-face monitoring during excavation of a radioactive plume at Mound Laboratory, Ohio

    International Nuclear Information System (INIS)

    A dig-face monitoring system consists of onsite hardware for collecting information on changing chemical, radiological, and physical conditions in the subsurface soil during the hazardous site excavation. A prototype dig-face system was take to Mount Laboratory for a first trial. Mound Area 7 was the site of historical disposals of 232Th, 227Ac, and assorted debris. The system was used to monitor a deep excavation aimed at removing 227Ac-contaminated soils. Radiological, geophysical, and topographic sensors were used to scan across the excavation dig-face at four successive depths as soil was removed. A 3-D image of the contamination plumes was developed; the radiation sensor data indicated that only a small portion of the excavated soil volume was contaminated. The spatial information produced by the dig-face system was used to direct the excavation activities into the area containing the 227Ac and to evaluate options for handling the separate 232Th plume

  15. Reactor production of Thorium-229.

    Science.gov (United States)

    Hogle, Susan; Boll, Rose Ann; Murphy, Karen; Denton, David; Owens, Allison; Haverlock, Tamara J; Garland, Marc; Mirzadeh, Saed

    2016-08-01

    Limited availability of (229)Th for clinical applications of (213)Bi necessitates investigation of alternative production routes. In reactor production, (229)Th is produced from neutron transmutation of (226)Ra, (228)Ra, (227)Ac and (228)Th. Irradiations of (226)Ra, (228)Ra, and (227)Ac targets at the Oak Ridge National Laboratory High Flux Isotope Reactor result in yields of (229)Th at 26 days of 74.0±7.4MBq/g, 260±10MBq/g, and 1200±50MBq/g, respectively. Intermediate radionuclide yields and cross sections are also studied. PMID:27163437

  16. Gclust Server: 137076 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 137076 PoTR_587240 Cluster Sequences - 227 eugene3.209210001 1 1.00e-99 14.29 0.0 0....0 0.0 0.0 0.0 Show 137076 Cluster ID 137076 Sequence ID PoTR_587240 Link to cluster sequences Cluster Seque...nces Link to related sequences - Sequence length 227 Representative annotation eugene3.209210001 Number of S...es not appearing in this cluster ATH: 0 OSA: 0 PPT: 0 CRE: 0 OTAU: 0 CME: 0 GTH: 0 PFA: 0 PTR: 0 TPS: 0 Ter:

  17. Confiabilidad del análisis de ADN en pruebas de paternidad para bovinos Brahman y Brangus en México

    OpenAIRE

    RIOJAS VALDÉS, VÍCTOR M.; Gómez de la Fuente, Juan Carlos, 1966-; SALINAS MELÉNDEZ, JOSÉ A.; Montes de Oca Luna, Roberto.; Wong González, Alfredo.

    2006-01-01

    En el presente estudio se calcularon las probabilidades de exclusión (PE) de ocho microsatélites de ADN (BM1824, BM 2113, SPS 115, ETH 3, ETH 10, ETH 225, TGLA122 y TGLA 227) para determinar la confiabilidad del análisis de ADN como método para la realización de pruebas de paternidad. Los microsatélites de ADN más informativos dentro del panel analizado para la raza Brahman fueron: BM 2113, SPS 115, ETH 10, ETH 225, TGLA 122 y TGLA 227 (PE´s de 0.72, 0.54, 0.45, ...

  18. Formerly utilized MED/AEC sites remedial action program. Radiological survey of the E. I. Du Pont de Nemours and Co. , Deepwater, New Jersey. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-12-01

    The results of a radiological survey of the E. I. Du Pont Company, Deepwater, New Jersey, are presented in this report. During the 1940's this site was used for development of a process for the conversion of uranium oxide to produce uranium tetrafluoride and small quantities of uranium metal. The survey included measurements of the following: residual alpha and beta--gamma contamination levels, both fixed and transferable, in the one remaining uranium tetrafluoride operations building; external gamma radiation levels at 1 m above the surface inside this building and at outdoor locations where radioactive materials were handled; radon and radon daughter concentrations in the air in the operations building; uranium, radium, actinium, and thorium concentrations in soil and water on and near the site; and the airborne concentrations of uranium, thorium, and radium in the operations building. Elevated concentrations of uranium were found in residues from the operations building and in some surface and subsurface soil samples. Alpha and beta--gamma contamination levels in some areas of the operations building were above the limits of current federal guidelines set for the release of property for unrestricted use. 18 figures, 11 tables.

  19. An Ion Exchange Study of Possible Hydridized 5f Bonding in theActinides

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, R.M.; Street, Jr., K.; Seaborg, G.T.

    1951-08-28

    A study has been made of the elution behavior of curium(III), americium(III), plutonium(III), actinium(III), plutonium(IV), neptunium(IV), uraniuM(IV), thorium(IV), neptunium(V), plutonium (VI), uranium (VI), lanthanum(III), cerium(III), europium(III), ytterbium(III), ytterium(III), strontium(II), barium(II), radium(II), cesium(I) with 3.2 M, 6.2 M, 9.3 M, and 12.2 M HCl solutions from Dowex-50 cation exchange resin columns. These elutions show that in high concentrations of hydrochloric acid the actinides form complex ions with chloride ion to a much greater extent than the lanthanides. The strengths of the tripositive actinide complex ions apparently go in the order plutonium > americium> curium, although their ionic radii also decrease in this same order. To explain these results, a partial covalent character may be ascribed to the bonding in the transuranium complex ions. It is shown that a reasonable structure for such covalent bonding involves hybridization of the 5f orbitals in the actinide elements.

  20. Extending the north-east limit of the chart of nuclides

    CERN Document Server

    Benlliure, J; Kurtukian-Nieto, T; Schmidt, K -H; Audouin, L; Blank, B; Becker, F; Casarejos, E; Cortina-Gil, D; Enqvist, T; Fernández, B; Fernández-Ordóñez, M; Giovinazzo, J; Henzlova, D; Junghans, A R; Jurado, B; Napolitani, P; Pereira, J; Rejmund, F; Yordanov, O

    2010-01-01

    The existence of nuclei with exotic combinations of protons and neutrons provides fundamental information on the forces acting between nucleons. The maximum number of neutrons a given number of protons can bind, neutron drip line1, is only known for the lightest chemical elements, up to oxygen. For heavier elements, the larger its atomic number, the farther from this limit is the most neutron-rich known isotope. The properties of heavy neutron-rich nuclei also have a direct impact on understanding the observed abundances of chemical elements heavier than iron in our Universe. Above half of the abundances of these elements are thought to be produced in rapid-neutron capture reactions, r-process, taking place in violent stellar scenarios2 where heavy neutron-rich nuclei, far beyond the ones known up today, are produced. Here we present a major step forward in the production of heavy neutron-rich nuclei: the discovery of 73 new neutron-rich isotopes of chemical elements between tantalum (Z=72) and actinium (Z=89...

  1. Liquid Scintillation Counting of Environmental Radioisotopes: A Review of the Impact of Background Reduction

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, Matthew; Bernacki, Bruce E.; Erchinger, Jennifer L.; Finn, Erin C.; Fuller, Erin S.; Hoppe, Eric W.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Orrell, John L.; Panisko, Mark E.; Warren, Glen A.; Wright, Michael E.

    2016-03-09

    Liquid scintillation counting (LSC) is a versatile and commonplace method for radiometric measurement of charged particle emitting radionuclides. The LSC method provides utility in a range of environmental science applications including hydrological studies of water transport, anthropogenic releases of radionuclides into the environment, and vertical mixing rates within oceans. Instrumental measurement background is one limiting factor of radiometric measurement sensitivity. As part of the development of a custom low background LSC system located in a shallow underground laboratory at Pacific Northwest National Laboratory, a number of measurement applications of LSC have been considered and are summarized here. The focus is on determining which aspects of such measurements would gain the greatest benefit from the reduction of LSC backgrounds by a factor of 10-100 relative to values reported in the literature. Examples of benefits include lowering the minimum detectable activity, reducing the sample size required, and shortening the elapsed timeline of the processing and analysis sequence. In particular tritium, strontium, and actinium isotopes are examined as these isotopes cover a range of requirements related to the LSC measurement method (e.g., 3H: low energy; Sr: spectral deconvolution; Ac: alpha/beta discrimination).

  2. Purification of lanthanides for double beta decay experiments

    Energy Technology Data Exchange (ETDEWEB)

    Polischuk, O. G. [Institute for Nuclear Research, MSP 03680 Kyiv, Ukraine and INFN, Section of Rome, La Sapienza, I-00185 Rome (Italy); Barabash, A. S. [Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Belli, P. [INFN, Section of Rome Tor Vergata, I-00133 Rome (Italy); Bernabei, R. [INFN, Section of Rome Tor Vergata, I-00133 Rome, Italy and Department of Physics, University of Rome Tor Vergata, I-00133 Rome (Italy); Boiko, R. S.; Danevich, F. A.; Mokina, V. M.; Poda, D. V.; Tretyak, V. I. [Institute for Nuclear Research, MSP 03680 Kyiv (Ukraine); Cappella, F.; Incicchitti, A. [INFN, Section of Rome La Sapienza, I-00185 Rome, Italy and Department of Physics, University of Rome La Sapienza, I-00185 Rome (Italy); Cerulli, R.; Laubenstein, M.; Nisi, S. [INFN, Gran Sasso National Laboratories, I-67100 Assergi (Aq) (Italy)

    2013-08-08

    There are several potentially double beta active isotopes among the lanthanide elements. However, even high purity grade lanthanide compounds contain {sup 238}U, {sup 226}Ra and {sup 232,228}Th typically on the level of ∼ (0.1 - 1) Bq/kg. The liquid-liquid extraction technique was used to remove traces of U, Ra and Th from CeO{sub 2}, Nd{sub 2}O{sub 3} and Gd{sub 2}O{sub 3}. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe γ spectrometry at the underground Gran Sasso National Laboratories of the INFN (Italy). After the purification the radioactive contamination of gadolinium oxide by Ra and Th was decreased at least one order of magnitude. The efficiency of the approach to purify cerium oxide from Ra was on same level, while the radioactive contamination of neodymium sample before and after the purification is below the sensitivity of analytical methods. The purification method is much less efficient for chemically very similar radioactive elements like lanthanum, lutetium and actinium. R and D of the methods to remove the pollutions with improved efficiency is in progress.

  3. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin.

    Science.gov (United States)

    Nour, S; El-Sharkawy, A; Burnett, W C; Horwitz, E P

    2004-12-01

    The objective of this work was to establish a new procedure for 228Ra determination of natural waters via preconcentration of radium on MnO2 and separation of its daughter, 228Ac, using Diphonix ion exchange resin. Following removal of potential interferences via passage through an initial Diphonix Resin column, the first daughter of 228Ra, 228Ac, is isolated by chromatographic separation via a second Diphonix column. A holding time of > 30 h for 228Ac ingrowth in between the two column separations ensures secular equilibrium. Barium-133 is used as a yield tracer. Actinium-228 is eluted from the second Diphonix Resin with 5 ml 1M 1-Hydroxyethane-1,1-diphosphonic acid (HEDPA) and quantified by addition of scintillation cocktail and LSC counting. Radium (and 133Ba) from the load and rinse solutions from the 2nd Diphonix column may be prepared for alpha spectrometry (for determination of 223Ra, 224Ra, and 226Ra) by BaSO4 microprecipitation and filtration. Decontamination tests indicate that U, Th, and Ra series nuclides do not interfere with these measurements, although high contents of 90Sr (90Y) require additional treatment for accurate measurement of 228Ra. Addition of stable Sr as a "hold back" carrier during the initial MnO2 preconcentration step was shown to remove most 90Sr interference.

  4. Soil and river sediments radionuclides monitoring at Aramar Experimental Center: an historical overview

    Energy Technology Data Exchange (ETDEWEB)

    Segre, Nadia; Fagundes, Rosane Correa, E-mail: nadia.segre@ctmsp.mar.mil.br [Centro Tecnologico da Marinha (CTM-SP/CEA/LARE), Ipero, SP (Brazil). Centro Experimental Aramar. Lab. Radioecologico; Moraes, Marco Antonio P.V. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    In order to evaluate possible effects to the environment resulting from the implementation of the Centro Tecnologico da Marinha - Centro Experimental Aramar (CTMSP-CEA) at Ipero in Sao Paulo state, Brazil, which came into operation in 1989, an Environmental Monitoring Program (PMA) was established in October, 1987. One of the aims of this program is to monitor the soil and river sediments radionuclides levels at CEA and beyond its boundary. The utilization of statistical tools to evaluate the results of radiometric environmental monitoring is a procedure required by National Nuclear Energy Commission (CNEN). The box plot is a simple statistical tool for displaying data. The central tendency and dispersion of the results as well as the observation of unusual results (outliers) in the dataset are easily visualized. Control chart is a graph that maps data and provides a picture of how a process is performing over time. A control chart always has a central line for the mean, an upper line for the upper control limit and a lower line for the lower control limit. Box plots and control charts were used to visualize the annual amount of natural uranium, lead-214, actinium-228 and lead-212 in soil and river sediment detected between 1987 and 2011, considering the measurements of all monitored places each year. This historical observation shows that, in average, the results obtained are below than the 1987-1988 levels (CEA's pre-operational) or below than the backgrounds radionuclides values. (author)

  5. Background radiation and individual dosimetry in the costal area of Tamil Nadu, India.

    Science.gov (United States)

    Matsuda, Naoki; Brahmanandhan, G M; Yoshida, Masahiro; Takamura, Noboru; Suyama, Akihiko; Koguchi, Yasuhiro; Juto, Norimichi; Raj, Y Lenin; Winsley, Godwin; Selvasekarapandian, S

    2011-07-01

    South coast of India is known as the high-level background radiation area (HBRA) mainly due to beach sands that contain natural radionuclides as components of the mineral monazite. The rich deposit of monazite is unevenly distributed along the coastal belt of Tamil Nadu and Kerala. An HBRA site that laid in 2×7 m along the sea was found in the beach of Chinnavillai, Tamil Nadu, where the maximum ambient dose equivalent reached as high as 162.7 mSv y(-1). From the sands collected at the HBRA spot, the high-purity germanium semi-conductor detector identified six nuclides of thorium series, four nuclides of uranium series and two nuclides belonging to actinium series. The highest radioactivity observed was 43.7 Bq g(-1) of Th-228. The individual dose of five inhabitants in Chinnavillai, as measured by the radiophotoluminescence glass dosimetry system, demonstrated the average dose of 7.17 mSv y(-1) ranging from 2.79 to 14.17 mSv y(-1).

  6. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    NA

    2004-11-22

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this modeling activity is to predict dissolved concentrations or solubility limits for 14 elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) important to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are in the form of tabulated functions with pH and log (line integral) CO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. The output data from this report are fundamental inputs for Total System Performance Assessment for the License Application (TSPA-LA) to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for all of the actinides. These models cover broad ranges of environmental conditions so that they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or otherwise addressed.

  7. A Critical Review of Alpha Radionuclide Therapy-How to Deal with Recoiling Daughters?

    Science.gov (United States)

    de Kruijff, Robin M; Wolterbeek, Hubert T; Denkova, Antonia G

    2015-01-01

    This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. PMID:26066613

  8. A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    Science.gov (United States)

    de Kruijff, Robin M.; Wolterbeek, Hubert T.; Denkova, Antonia G.

    2015-01-01

    This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. PMID:26066613

  9. A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    Directory of Open Access Journals (Sweden)

    Robin M. de Kruijff

    2015-06-01

    Full Text Available This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET. Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium, 223Ra, and 225Ac (actinium can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue.

  10. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  11. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  12. Rutherford's curriculum vitae, 1894-1907.

    Science.gov (United States)

    Cohen, M

    1995-06-01

    A single page, handwritten document was discovered when the Macdonald Physics building of McGill University in Montreal was gutted in 1978. This proved to be the draft of Ernest Rutherford's curriculum vitae (C.V.) covering the years 1894-1907, probably written in the autumn of 1906 when Rutherford was preparing to leave McGill. The C.V. contains 21 headings in chronological order, referring to research and other activities of Rutherford and his coauthors (especially Soddy and Barnes), plus a further set of headings relating to the associated investigations of Rutherford's team, including Eve and Hahn. A transcript of the document is provided, although in several places, Rutherford's handwriting is difficult to interpret, and the significance of his abbreviations is not always clear. Each of the items in the C.V. is discussed briefly in this review, in the light both of Rutherford's personal career and of the contribution of his team to the development and understanding of radioactivity. This contribution included the cause and nature of radioactivity (with Soddy), energy aspects of radioactive decay (with Barnes), elucidation of the uranium-radium, thorium and actinium series (Godlewski and Hahn), the radioactivity of the earth and atmosphere (Eve), the nature of the gamma rays (Eve) and, perhaps most important of all, the nature and properties of the alpha particle (Rutherford himself). The latter investigations led directly to Rutherford's later work in Manchester, including the nuclear model of the atom and artificial disintegration of the nucleus.

  13. 77 FR 65642 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-10-30

    ... Certification Maintenance Requirement (CMR) Task Into the Maintenance Program Instead of Issuing an NPRM (73 FR... (73 FR 32256, June 6, 2008) by proposing repetitive operational tests of the engine fuel suction feed... information on the availability of this material at the FAA, call 425-227-1221. Examining the AD Docket...

  14. 78 FR 39571 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-07-02

    ... Suction Feed System.'' UAL stated that it has incorporated this MRB task into its maintenance program at... information on the availability of this material at the FAA, call 425-227-1221. Examining the AD Docket You... the Federal Register on July 9, 2012 (77 FR 40307). The original NPRM (73 FR 32248, June 6,...

  15. Data of evolutionary structure change: 1XICA-4XIMD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1XICA-4XIMD 1XIC 4XIM A D YQPTPEDRFTFGLWTVGWQGRDPFGDATRRALDPVESVQ...Y CA 227 TYR CA 313 SER CA 291 GLY CA 397 4X...IM D 4XIMD DLLENG...07 GLN CA 106 ALA CA 123 4XIM D 4XIMD TPTLNPGEGYAE

  16. 77 FR 59339 - Patents, Data, and Copyrights; CFR Correction

    Science.gov (United States)

    2012-09-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 227 Patents, Data, and Copyrights; CFR Correction In Title 48 of the Code of Federal Regulations, Chapter 2 (Parts 201--299), revised as of October 1,...

  17. 48 CFR 970.5227-6 - Patent indemnity-subcontracts.

    Science.gov (United States)

    2010-10-01

    ... subcontractors for any contract work subcontracted in accordance with FAR 48 CFR 52.227-3. (End of clause) ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Patent indemnity... for Management and Operating Contracts 970.5227-6 Patent indemnity—subcontracts. Insert the...

  18. Participation Patterns of Korean Adolescents in School-Based Career Exploration Activities

    Science.gov (United States)

    Rojewski, Jay W.; Lee, In Heok; Hill, Roger B.

    2014-01-01

    Variations in the school-based career exploration activities of Korean high school students were examined. Data represented 5,227 Korean adolescents in Grade 11 contained in the Korean Education Longitudinal Study of 2005, a nationally representative longitudinal database administered by the Korean Educational Development Institute. Latent class…

  19. Whole-Genome Sequence of "Candidatus Liberibacter asiaticus" from a Huanglongbing-Affected Citrus Tree in Central Florida.

    Science.gov (United States)

    Zheng, Z; Sun, X; Deng, X; Chen, J

    2015-01-01

    Here, we report the draft genome sequence of "Candidatus Liberibacter asiaticus" strain FL17, isolated from a huanglongbing (HLB)-affected citrus tree in central Florida. The FL17 genome comprised 1,227,253 bp, with a G+C content of 36.5%, 1,175 predicted open reading frames, and 53 RNA genes. PMID:25792067

  20. Whole-Genome Sequence of “Candidatus Liberibacter asiaticus” from a Huanglongbing-Affected Citrus Tree in Central Florida

    OpenAIRE

    Z. Zheng; X. Sun; Deng, X.; J. Chen

    2015-01-01

    Here, we report the draft genome sequence of “Candidatus Liberibacter asiaticus” strain FL17, isolated from a huanglongbing (HLB)-affected citrus tree in central Florida. The FL17 genome comprised 1,227,253 bp, with a G+C content of 36.5%, 1,175 predicted open reading frames, and 53 RNA genes.

  1. EST Table: FY000066 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY000066 bmov1d01 11/12/09 n.h 11/11/04 83 %/227 aa ref|XP_001599258.1| PREDICTED: similar to Dscam... [Nasonia vitripennis] 11/11/04 76 %/226 aa FBpp0234977|DvirDscam-PA 11/11/04 low homology 1

  2. Structure-function relationship of a plant NCS1 member - Homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from arabidopsis

    KAUST Repository

    Witz, Sandra

    2014-03-12

    Plastidic uracil salvage is essential for plant growth and development. So far, PLUTO, the plastidic nucleobase transporter from Arabidopsis thaliana is the only known uracil importer at the inner plastidic membrane which represents the permeability barrier of this organelle. We present the first homology model of PLUTO, the sole plant NCS1 member from Arabidopsis based on the crystal structure of the benzyl hydantoin transporter MHP1 from Microbacterium liquefaciens and validated by molecular dynamics simulations. Polar side chains of residues Glu-227 and backbones of Val-145, Gly-147 and Thr-425 are proposed to form the binding site for the three PLUTO substrates uracil, adenine and guanine. Mutational analysis and competition studies identified Glu-227 as an important residue for uracil and to a lesser extent for guanine transport. A differential response in substrate transport was apparent with PLUTO double mutants E227Q G147Q and E227Q T425A, both of which most strongly affected adenine transport, and in V145A G147Q, which markedly affected guanine transport. These differences could be explained by docking studies, showing that uracil and guanine exhibit a similar binding mode whereas adenine binds deep into the catalytic pocket of PLUTO. Furthermore, competition studies confirmed these results. The present study defines the molecular determinants for PLUTO substrate binding and demonstrates key differences in structure-function relations between PLUTO and other NCS1 family members. 2014 Witz et al.

  3. 75 FR 35070 - American Indians Into Medicine; Notice of Competitive Grant Applications for American Indians...

    Science.gov (United States)

    2010-06-21

    ...-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the... entities to enhance the education of Indian students. e. Identify existing university tutoring, counseling and student support services. Part C: Program Report (3 Pages) a. Provide data and...

  4. How Well Can the Theory of Planned Behavior Account for Occupational Intentions?

    Science.gov (United States)

    Arnold, John; Loan-Clarke, John; Coombs, Crispin; Wilkinson, Adrian; Park, Jennifer; Preston, Diane

    2006-01-01

    We tested the capacity of an extended version of the theory of planned behavior (TPB) to account for intentions to work for the UK's National Health Service (NHS) as a nurse, physiotherapist or radiographer amongst three groups: professionally unqualified (N=507), in professional training (N=244), and professionally qualified (N=227). We found…

  5. Evaluation and reselection of wheat resistance to Russian wheat aphid biotype 2

    Science.gov (United States)

    Russian wheat aphid (RWA, Diuraphis noxia, Mordvilko) biotype 2 (RWA2) is virulent to most known RWA resistance genes and severely threatens wheat production in the hard winter wheat area of the US western Great Plains. We determined RWA2 reactions of 386 cultivars from China, 227 advanced breeding...

  6. Phonological Processing Skills and Early Reading Abilities in Hong Kong Chinese Kindergarteners Learning to Read English as a Second Language

    Science.gov (United States)

    Chow, Bonnie Wing-Yin; McBride-Chang, Catherine; Burgess, Stephen

    2005-01-01

    The present 9-month longitudinal study investigated relations between Chinese native language phonological processing skills and early Chinese and English reading abilities among 227 kindergarteners in Hong Kong. Phonological awareness, rapid automatized naming, and short-term verbal memory differed in their relations to concurrent and subsequent…

  7. Ruby Splendor nectarine

    Science.gov (United States)

    The Agricultural Research Service hereby releases for propagation the new nectarine variety ‘Ruby Splendor,’ tested previously as Y426-227. ‘Ruby Splendor’ was first selected in 2001 among 70 seedlings from the planned hybridization of two unnamed nectarine selections. Fruit of ‘Ruby Splendor’ ripen...

  8. Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from Arabidopsis.

    Science.gov (United States)

    Witz, Sandra; Panwar, Pankaj; Schober, Markus; Deppe, Johannes; Pasha, Farhan Ahmad; Lemieux, M Joanne; Möhlmann, Torsten

    2014-01-01

    Plastidic uracil salvage is essential for plant growth and development. So far, PLUTO, the plastidic nucleobase transporter from Arabidopsis thaliana is the only known uracil importer at the inner plastidic membrane which represents the permeability barrier of this organelle. We present the first homology model of PLUTO, the sole plant NCS1 member from Arabidopsis based on the crystal structure of the benzyl hydantoin transporter MHP1 from Microbacterium liquefaciens and validated by molecular dynamics simulations. Polar side chains of residues Glu-227 and backbones of Val-145, Gly-147 and Thr-425 are proposed to form the binding site for the three PLUTO substrates uracil, adenine and guanine. Mutational analysis and competition studies identified Glu-227 as an important residue for uracil and to a lesser extent for guanine transport. A differential response in substrate transport was apparent with PLUTO double mutants E227Q G147Q and E227Q T425A, both of which most strongly affected adenine transport, and in V145A G147Q, which markedly affected guanine transport. These differences could be explained by docking studies, showing that uracil and guanine exhibit a similar binding mode whereas adenine binds deep into the catalytic pocket of PLUTO. Furthermore, competition studies confirmed these results. The present study defines the molecular determinants for PLUTO substrate binding and demonstrates key differences in structure-function relations between PLUTO and other NCS1 family members. PMID:24621654

  9. SOA Direct Modulation in Wavelength-Selectable Laser Array Light Sources

    Institute of Scientific and Technical Information of China (English)

    Kazuo; Kasaya; Ken; Tsuzuki; Hiroaki; Sanjoh; Yasuo; Shibata; Yuichi; Tohmori

    2003-01-01

    We demonstrated, for the first time, 2.5-Gb/s SOA direct modulation in the wavelength-selectable DFB laser array. The SOA direct modulation was achieved in the wide tuning range of 22.7nm by selecting arrayed laser and tuning the temperature. 40-km transmission was also confirmed..

  10. Metaphor Perceptions of Pre-Service Teachers towards Mathematics and Mathematics Education in Preschool Education

    Science.gov (United States)

    Keles, Oguz; Tas, Isil; Aslan, Durmus

    2016-01-01

    The aim of this study was to identify the thoughts of pre-service teachers, who play an important role in the early preschool experience of children in mathematics, towards the concepts of mathematics and education of mathematics with the help of metaphors. The study group of the research consists of a total of 227 pre-service teachers at the…

  11. 77 FR 76537 - Notice of Extension of Public Comment Period: Request for Comments (RFC)-Federal Cybersecurity...

    Science.gov (United States)

    2012-12-28

    ... November 26, 2012 [FR Volume 77, Number 227, Doc No: 2012-28481] is issued by the Cyber Security and... Notice of Extension of Public Comment Period: Request for Comments (RFC)--Federal Cybersecurity Research...) has extended the public comment period for its Request for ] Comments (RFC)--Federal...

  12. 横浜で観測された酸性雨(1996年9月~1998年3月)

    OpenAIRE

    Murayama, Haruta

    1998-01-01

    Rain samples were collected adequately at the center of Yokohama city from September 1996 to March 1998. Total numbers of samples were 227. pH values and electric conductivity (E. C.) were measured immediately after catched samples and then chemical species were analyzed. This report is contained all observed data. Frequency of acid rain (pH

  13. Phosphorylation of mouse serine racemase regulates D-serine synthesis

    DEFF Research Database (Denmark)

    Foltyn, Veronika N; Zehl, Martin; Dikopoltsev, Elena;

    2010-01-01

    Serine racemase (SR) catalyses the synthesis of the transmitter/neuromodulator D-serine, which plays a major role in synaptic plasticity and N-methyl D-aspartate receptor neurotoxicity. We now report that SR is phosphorylated at Thr71 and Thr227 as revealed by mass spectrometric analysis and in v...

  14. THE PERCEPTION OF MUSIC SYMBOLS IN MUSIC READING BY NORMAL CHILDREN AND BY CHILDREN GIFTED MUSICALLY.

    Science.gov (United States)

    PETZOLD, ROBERT G.

    THIS STUDY WAS CONCERNED WITH IDENTIFYING THE DIFFERENCES BETWEEN CHILDREN OF AVERAGE MUSICAL ABILITY AND CHILDREN GIFTED MUSICALLY AS THEY ENGAGED IN CERTAIN MUSIC ACTIVITIES. DATA WERE OBTAINED FROM TESTS OF 227 MADISON, WISCONSIN, PUBLIC SCHOOL CHILDREN, GRADES 4-6. THE TAPE-RECORDING TEST WAS IN 2 PHASES--(1) 89 CHILDREN, SELECTED AT RANDOM…

  15. 48 CFR 3427.472 - Advertising of awards clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Advertising of awards... Copyrights 3427.472 Advertising of awards clause. The contracting officer shall insert the clause in 3452.227-72, Advertising of Awards, in all solicitations and contracts other than purchase orders....

  16. 77 FR 74470 - Intent to Prepare an Environmental Impact Statement (EIS) for the Donlin Gold Project

    Science.gov (United States)

    2012-12-14

    ... 227 MW, supplied by a 313-mile, small-diameter (approximately 14-inches), natural gas pipeline from... excavation of an open pit, that ultimately would be approximately 2.2 miles long by 1 mile wide by 1,850 feet deep; a waste treatment facility (tailings impoundment) approximately 1 mile long, and...

  17. 糙皮侧耳和康氏木霉二步混合发酵生产饲料蛋白的研究%STUDY ON FORAGE PROTEIN PRODUCTION BY TWO-STEP MIXED CULTURE FERMENTATION WITH Pleurotus ostreatus AND Trichoderma koningii

    Institute of Scientific and Technical Information of China (English)

    陈敏

    2002-01-01

    研究了糙皮侧耳(Pleurotus ostreatus)和康氏木霉C-3(Trichoderma Koningii C-3)降解稻草生产饲料蛋白的发酵工艺.发酵产物的粗蛋白含量达到 22.7 %,粗纤维降解率为 34 %.

  18. 75 FR 21823

    Science.gov (United States)

    2010-04-26

    ... Number Number 227 Occupational Exposure to Beryllium 1218-AB76 228 Methylene Chloride (Section 610 Review... Information (RFI) (67 FR 70707) to solicit information pertinent to occupational exposure to beryllium... Chloride (RIN 1218-AC23) Bloodborne Pathogens (RIN 1218-AC34) All interested members of the public...

  19. 48 CFR 927.303 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... is a domestic small business or nonprofit organization as defined at (FAR) 48 CFR 27.301, except... (but see (FAR) 48 CFR 27.304-3 regarding contracts for construction work or architect-engineer services... use the clause at (FAR) 48 CFR 52.227-12 except in situations where patent counsel grants a...

  20. Depressive symptoms in adolescence : Longitudinal links with maternal empathy and psychological control

    NARCIS (Netherlands)

    Werner, Lente L. A. A.; Van der Graaff, Jolien; Meeus, W.H.J.; Branje, Susan J. T.

    2016-01-01

    Building on self-determination theory (Deci and Ryan in Psychological Inquiry, 11, 227-268. doi:10.1207/S15327965PLI1104_01, 2000), the aim of the current study was to examine the role of maternal affective and cognitive empathy in predicting adolescents' depressive symptoms, through mothers' psycho

  1. Depressive Symptoms in Adolescence: Longitudinal Links with Maternal Empathy and Psychological Control

    NARCIS (Netherlands)

    Werner, L.A.A.; van der Graaff, J.; Meeus, W.H.J.; Branje, S.J.T.

    2016-01-01

    Building on self-determination theory (Deci and Ryan in Psychological Inquiry, 11, 227-268. doi:10.1207/ S15327965PLI1104_01, 2000), the aim of the current study was to examine the role of maternal affective and cognitive empathy in predicting adolescents’ depressive symptoms, through mothers’ psych

  2. Translation and Validation of the Malay Subjective Happiness Scale

    Science.gov (United States)

    Swami, Viren

    2008-01-01

    The Subjective Happiness Scale (Lyubomirsky and Lepper, "Social Indicators Research," 46, 137-155, 1999) is a brief measure for assessing subjective happiness. The reliability and validity of the Malay version of the Subjective Happiness Scale was investigated in a community sample of 290 Chinese and 227 Malays in Malaysia. Results showed that the…

  3. 40 CFR 228.15 - Dumping sites designated on a final basis.

    Science.gov (United States)

    2010-07-01

    ... Implementation Manual (SMMP Implementation Manual) containing more detailed operational guidance. The SMMP Implementation Manual may be periodically revised as necessary; proposed revisions to the SMMP Implementation... practicable alternatives (as defined in 40 CFR 227.16(b)) to open-water disposal in Long Island Sound and...

  4. Dicty_cDB: VSJ836 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tocystis sp. DMP/02-328 mitoc... 34 2.8 CP000781_227( CP000781 |pid:none) Xanthobac..._713( CP000976 |pid:none) Borrelia duttonii Ly, complete g... 34 2.8 EF494739_11( EF494739 |pid:none) Blas

  5. EST Table: DY231350 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DY231350 EST02101 10/09/28 99 %/227 aa ref|NP_001037309.1| vitellogenin precursor [...s: Precursor dbj|BAA02444.1| vitellogenin precursor [Bombyx mori] dbj|BAA06397.1| vitellogenin [Bombyx mori

  6. EST Table: DN237644 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DN237644 EST00770 10/09/29 99 %/227 aa ref|NP_001037309.1| vitellogenin precursor [...s: Precursor dbj|BAA02444.1| vitellogenin precursor [Bombyx mori] dbj|BAA06397.1| vitellogenin [Bombyx mori

  7. EST Table: DN237680 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DN237680 EST00806 10/09/29 95 %/227 aa ref|NP_001037309.1| vitellogenin precursor [...s: Precursor dbj|BAA02444.1| vitellogenin precursor [Bombyx mori] dbj|BAA06397.1| vitellogenin [Bombyx mori

  8. Antibacterial activity of marine-derived fungi

    DEFF Research Database (Denmark)

    Christophersen, Carsten; Crescente, Oscar; Frisvad, Jens Christian;

    1998-01-01

    A total of 227 marine isolates of ubiqituous fungi were cultivated on different media and the secondary metabolite content of the extracts (ethyl acetate/chlorofonn/methanol 3 : 2 : 1) characterized by HPLC. The fungi were secured from animals, plants and sediments of Venezuelan waters (0-10 m...

  9. 20.9.Extrapyramidal disorder

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920191 Effect of 6-hydroxydopamine oncerebral catecholamines,lipid peroxidationand antioxidant enzymes in rat-concernedwith pathogensis of Parkinson’s disease.LIANG Liping (梁立平),JIANG Dehua (江德华).Dept Neurol,Neurolgic Instit,Tianjing,300052.Chin J Neurol and Psychiat 1991; 24 (4): 223-227.As an animal model of human Parkinson’s

  10. Quality of life among prostate cancer patients : A prospective longitudinal population-based study

    NARCIS (Netherlands)

    Schaake, Wouter; de Groot, Martijn; Krijnen, Wim P.; Langendijk, Johannes A.; van den Bergh, Alfons C. M.

    2013-01-01

    Purpose: To investigate the course of quality of life (QoL) among prostate cancer patients treated with external beam radiotherapy and to compare the results with QoL of a normal age-matched reference population. Patients and methods: The study population was composed of 227 prostate cancer patients

  11. The impact of gastrointestinal and genitourinary toxicity on health related quality of life among irradiated prostate cancer patients

    NARCIS (Netherlands)

    Schaake, Wouter; Wiegman, Erwin M; de Groot, Martijn; van der Laan, Hans Paul; van der Schans, Cees P.; van den Bergh, Alfons C M; Langendijk, Johannes A

    2014-01-01

    PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer. PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Eve

  12. 75 FR 36123 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2010-06-24

    ... in the Federal Register at 75 FR 18240, and no substantial comments were received. NSF is forwarding... mammal, or native bird). Use of the Information: The purpose of the regulations (45 CFR part 670) is to... amended by the Antarctic Science, Tourism, and Conservation Act of 1996, Public Law 104-227. Burden on...

  13. 78 FR 41805 - Agency Information Collection Activities: Comment Request

    Science.gov (United States)

    2013-07-11

    ... in the Federal Register at 78 FR 27260, and no comments were received. NSF is forwarding the proposed... mammal, or native bird). Use of the Information: The purpose of the regulations (45 CFR part 670) is to... amended by the Antarctic Science, Tourism, and Conservation Act of 1996, Public Law 104-227. Burden on...

  14. Screening of Elderly for Chronic Kidney Disease

    NARCIS (Netherlands)

    Lezaic, Visnja; Bajcetic, Sanja; Perunicic-Pekovic, Gordana; Bukvic, Danica; Dimkovic, Nada; Djukanovic, Ljubica

    2012-01-01

    Background and Aims: The frequency of chronic kidney disease (CKD) markers was assessed in two groups of patients over 60 years - one without and the other with hypertension. Methods: The cross-sectional study involved 585 asymptomatic elderly patients (227 males), 93 without and 492 with hypertensi

  15. 77 FR 71795 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2012-12-04

    ... Administration (MSHA) injury database, 227 knee injuries were reported in underground coal mining in 2007. With... wore no kneepads at all. Thus, the injury data and the results of this study suggest the need for the... designing more effective kneel-assist devices such as a kneepad and a padded support worn at the ankle...

  16. 76 FR 41705 - Approval and Promulgation of Implementation Plans; New York; Revised Format of Materials Being...

    Science.gov (United States)

    2011-07-15

    .... Part 212, General Process 9/22/94 9/25/01, 66 FR 48961 Emission Sources. Part 213, Contaminant... as a SIP revision. Part 226, Solvent Metal Cleaning 5/7/03 1/23/04, 69 FR 3240 Processes. Part 227... approved, they become part of the SIP. On May 22, 1997 (62 FR 27968), EPA revised the procedures...

  17. Explaining Changes in Mothers' Job Satisfaction Following Childbirth.

    Science.gov (United States)

    Holtzman, Mellisa; Glass, Jennifer

    1999-01-01

    Pregnant women (n=227) interviewed before and six and 12 months after childbirth reported declines in job satisfaction following birth. The following factors positively or negatively affected satisfaction: length of leave, ability to work at home, 30 to 35-hour work week, evening/rotating shifts, supervisor support, and child-care environment. (SK)

  18. Enhancing Autonomy-Supportive I-Thou Dialogue in Schools: Conceptualization and Socio-Emotional Effects of an Intervention Program

    Science.gov (United States)

    Kaplan, Haya; Assor, Avi

    2012-01-01

    We present a conceptualization and a 2 year program of autonomy-supportive I-Thou dialogue among teachers and students that is based on self-determination theory (Deci and Ryan in "Psychol Inq" 11(4):227-268, 2000) and Buber's (1960) philosophy. The program was applied in 18 seventh grade classes (420 students). Findings showed: (a) increases in…

  19. 50 CFR 17.42 - Special rules-reptiles.

    Science.gov (United States)

    2010-10-01

    ... the species Alligator mississippiensis, whether alive or dead, including any skin, part, product, egg... normal course of business, reproducible in the English language, and retained for 5 years from the date... 50 CFR 227.72(e). (vi) The prohibition against taking within the United States or the territorial...

  20. What Sexual Harassment Experiences Lead Respondents to Acknowledge Being Sexually Harassed? A Secondary Analysis of a University Survey.

    Science.gov (United States)

    Stockdale, Margaret S.; Vaux, Alan

    1993-01-01

    According to survey responses from 933 of 1,807 undergraduates, 227 of 1,006 graduate students, and 432 of 1,372 faculty/staff, experience of sexual seduction, coercion, or imposition increased the probability of acknowledgment of having been harassed. Probability of acknowledgment was not related to gender or form of harassment. (SK)

  1. Experimental determination of the slow-neutron wavelength distribution

    DEFF Research Database (Denmark)

    Lebech, Bente; Mikke, K.; Sledziewska-Blocka, D.

    1970-01-01

    Different experiments for determining the slow-neutron wavelength distribution in the region 227-3 meV have been carried out, and the results compared. It is concluded that the slow-neutron wave-length distribution can be determined accurately by elastic scattering on a pure incoherent or a pure...

  2. Distributing and Showing Farmer Learning Videos in Bangladesh

    Science.gov (United States)

    Bentley, Jeffery W.; Van Mele, Paul; Harun-ar-Rashid, Md.; Krupnik, Timothy J.

    2016-01-01

    Purpose: To describe the results of showing farmer learning videos through different types of volunteers. Design/Methodology/Approach: Semi-structured interviews with volunteers from different occupational groups in Bangladesh, and a phone survey with 227 respondents. Findings: Each occupational group acted differently. Shop keepers, tillage…

  3. 24 CFR 35.1325 - Abatement.

    Science.gov (United States)

    2010-04-01

    ...-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Methods and Standards for Lead-Paint... authorized by EPA, or by EPA at 40 CFR 745.227(e), and shall be completed by achieving clearance in... accordance with § 35.1355. Abatement of an intact, factory-applied prime coating on metal surfaces is...

  4. 40 CFR 63.11441 - What are the notification requirements?

    Science.gov (United States)

    2010-07-01

    ... glazed ceramic ware, you must certify that you are maintaining the peak temperature below 1540 °C (2800...) or (2). (2) For atomized glaze spray booths, you must certify that your facility's annual wet glaze usage is above or below 227 Mg/yr (250 tpy). (3) For atomized glaze spray booths located at a...

  5. 25 CFR 211.1 - Purpose and scope.

    Science.gov (United States)

    2010-04-01

    ... maximizes their best economic interests and minimizes any adverse environmental impacts or cultural impacts... regulations in 25 CFR parts 213 (Members of the Five Civilized Tribes of Oklahoma), 226 (Osage), or 227 (Wind... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF TRIBAL LANDS FOR...

  6. 75 FR 67974 - Ocean Transportation Intermediary License Revocations

    Science.gov (United States)

    2010-11-04

    ... Overseas Shipping. Address: 16680 Central Green Blvd, Houston, TX 77032. Date Revoked: September 23, 2010... Air Express, Inc. dba Rical Logistics. Address: One Cross Island Plaza, Suite 227, Rosedale, NY 11422... Logistics LLC. Address: 381 Blair Road, Avenel, NJ 07001. Date Revoked: October 21, 2010. Reason: Failed...

  7. Antibiotic susceptibility profiles for group B streptococci isolated from neonates, 1995-1998

    NARCIS (Netherlands)

    Lin, FYC; Azimi, PH; Weisman, LE; Philips, JB; Regan, J; Clark, P; Rhoads, GG; Clemens, J; Troendle, J; Pratt, E; Brenner, RA; Gill, [No Value

    2000-01-01

    Antibiotic susceptibility profiles were analyzed for 119 invasive and 227 colonizing strains of group B streptococci isolated from neonates at 6 US academic centers, All strains were susceptible to penicillin, vancomycin, chloramphenicol, and cefotaxime, The rate of resistance to erythromycin was 20

  8. The Trait Emotional Intelligence Questionnaire: Internal Structure, Convergent, Criterion, and Incremental Validity in an Italian Sample

    Science.gov (United States)

    Andrei, Federica; Smith, Martin M.; Surcinelli, Paola; Baldaro, Bruno; Saklofske, Donald H.

    2016-01-01

    This study investigated the structure and validity of the Italian translation of the Trait Emotional Intelligence Questionnaire. Data were self-reported from 227 participants. Confirmatory factor analysis supported the four-factor structure of the scale. Hierarchical regressions also demonstrated its incremental validity beyond demographics, the…

  9. 21 CFR 520.905d - Fenbendazole powder.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Fenbendazole powder. 520.905d Section 520.905d... DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.905d Fenbendazole powder. (a) Specifications. (1) Each 2-ounce packet contains 2.27 grams (4 percent) of fenbendazole plus other...

  10. Assessment of undiscovered conventional oil and gas resources of Bonaparte Basin, Browse Basin, Northwest Shelf, and Gippsland Basin Provinces, Australia, 2011

    Science.gov (United States)

    Pollastro, Richard M.; Brownfield, Michael E.; Charpentier, Ronald R.; Cook, Troy A.; Klett, Timothy R.; Kirschbaum, Mark A.; Pitman, Janet K.; Schenk, Christopher J.

    2012-01-01

    Using a geology-based assessment methodology, the U.S. Geological Survey estimated means of 4.7 billion barrels of undiscovered oil and 227 trillion cubic feet of undiscovered natural gas in three major offshore petroleum basins of northwest Australia and in the Gippsland Basin of southeast Australia.

  11. Go4Life

    Medline Plus

    Full Text Available ... CC 2:48 Play next Play now Go4Life Exercise--Back Of Leg Stretch - Duration: 2 minutes, 48 ... CC 2:27 Play next Play now Go4Life Exercise--Ankle Stretch - Duration: 2 minutes, 27 seconds. National ...

  12. Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2

    DEFF Research Database (Denmark)

    Christiansen, Michael; Hedley, Paula L; Theilade, Juliane;

    2014-01-01

    , in 31.2% of cases, was based on the type of mutation identified (nonsense, insertion/deletion, frameshift or splice-site). Functional data was available for 22.7% of the missense mutations. None of the mutations were found in 364 Danish alleles and only three, all functionally characterised, were...

  13. Trahviüksused Teises maailmasõjas / Rain Leisi

    Index Scriptorium Estoniae

    Leisi, Rain

    2008-01-01

    Trahviüksustest, vanglatest ja koonduslaagritest, kuhu saadeti süütegusid toime pannud sõjaväelased Teise Maailmasõja ajal Saksamaal ja Venemaal. Lisatud: [Jossif Stalini 28. juuli 1942 käskkiri nr. 227] ; käskkirjas nr. 277 käskis Stalin

  14. Comparing Diagnostic Outcomes of Autism Spectrum Disorder Using "DSM-IV-TR" and "DSM-5" Criteria

    Science.gov (United States)

    Harstad, Elizabeth B.; Fogler, Jason; Sideridis, Georgios; Weas, Sarah; Mauras, Carrie; Barbaresi, William J.

    2015-01-01

    Controversy exists regarding the "DSM-5" criteria for ASD. This study tested the psychometric properties of the "DSM-5" model and determined how well it performed across different gender, IQ, and "DSM-IV-TR" sub-type, using clinically collected data on 227 subjects (median age = 3.95 years, majority had IQ > 70).…

  15. Improving treatment decisions from radiographs: effect of a decision aid

    NARCIS (Netherlands)

    P.A. Mileman; W.B. van den Hout

    2009-01-01

    Purpose: To test whether dental students’ accuracy of treatment decision making for dentine caries using radiographs improved after using a decision aid (DA). Methods: Dental students (n = 227) assessed the need for treatment for proximal surfaces of a test set of radiographs for a scenario patient.

  16. Cross-ethnic Friendships and Sense of Social-Emotional Safety in a Multiethnic Middle School : An Exploratory Study

    NARCIS (Netherlands)

    Munniksma, Anke; Juvonen, Jaana

    2012-01-01

    This exploratory study examined whether cross-ethnic friendships are related to students' sense of social-emotional safety in a multiethnic middle school. The analysis sample (n = 227) consisted of Latino (57%) and White (43%) sixth-and seventh-grade students. Although a strong preference for same-e

  17. 78 FR 66427 - Crowdfunding

    Science.gov (United States)

    2013-11-05

    ... (July 10, 2013) [78 FR 44771 (July 24, 2013)] (``General Solicitation Adopting Release'') (adopting... for Accredited Investors, Release No. 33-9287 (Dec. 21, 2011) [76 FR 81793 (Dec. 29, 2011)]. In... November 5, 2013 Part II Securities and Exchange Commission 17 CFR Parts 200, 227, 232 et al....

  18. Employment, Education, and Emigration: The FYR of Macedonia

    Science.gov (United States)

    Nikolovska, Margareta

    2004-01-01

    The transitional process of the FYR of Macedonia since independence in 1991 has been marked by a severe economic crisis, which has led to a significant increase in the levels of unemployment (31.9 percent in 2002) and poverty (22.7 percent in 2001). The turbulent situation in the Balkan region (war in the countries of the Former Yugoslavia) and…

  19. Developing a Mobile Game Environment to Support Disadvantaged Learners

    NARCIS (Netherlands)

    Schmitz, Birgit; Hoffmann, Marvin; Klamma, Ralf; Klemke, Roland; Specht, Marcus

    2012-01-01

    Schmitz, B., Hoffmann, M., Klamma, R., Klemke, R., & Specht, M. (2012). Developing a Mobile Game Environment to Support Disadvantaged Learners. Proceedings of 12th IEEE International Conference on Advanced Learning Technologies (ICALT 2012) (pp. 223-227). July, 4-6, 2012, Rome, Italy: IEEE Computer

  20. 75 FR 18240 - Comment Request: National Science Foundation-Applicant Survey

    Science.gov (United States)

    2010-04-09

    ... technology; and (d) ways to minimize the burden of the collection of information on respondents, including through the use of automated collection techniques or other forms of information technology. DATES... by the Antarctic Science, Tourism, and Conservation Act of 1996, Public Law 104-227. Burden on...

  1. Mood, Anxiety, and Substance-Use Disorders and Suicide Risk in a Military Population Cohort

    Science.gov (United States)

    Conner, Kenneth R.; McCarthy, Michael D.; Bajorska, Alina; Caine, Eric D.; Tu, Xin M.; Knox, Kerry L.

    2012-01-01

    There are meager prospective data from nonclinical samples on the link between anxiety disorders and suicide or the extent to which the association varies over time. We examined these issues in a cohort of 309,861 U.S. Air Force service members, with 227 suicides over follow-up. Mental disorder diagnoses including anxiety, mood, and substance-use…

  2. School Functioning in Youth with and without Anxiety Disorders: Comparisons by Diagnosis and Comorbidity

    Science.gov (United States)

    Mychailyszyn, Matthew P.; Mendez, Julia L.; Kendall, Philip C.

    2010-01-01

    This article reports on school functioning for 227 youth ages 7-14 (M = 10.3) with principal diagnoses of separation anxiety disorder (n = 40), social phobia (n = 58), generalized anxiety disorder (n = 76), or no diagnoses (n = 53). School functioning data were gathered via parent and teacher report. Youth with no diagnoses demonstrated…

  3. Cross-Ethnic Friendships and Sense of Social-Emotional Safety in a Multiethnic Middle School: An Exploratory Study

    Science.gov (United States)

    Munniksma, Anke; Juvonen, Jaana

    2012-01-01

    This exploratory study examined whether cross-ethnic friendships are related to students' sense of social-emotional safety in a multiethnic middle school. The analysis sample (n = 227) consisted of Latino (57%) and White (43%) sixth- and seventh-grade students. Although a strong preference for same-ethnic friendships was found for both ethnic…

  4. Cross-ethnic friendships and sense of social-emotional safety in multi-ethnic middle school: An exploratory study

    NARCIS (Netherlands)

    Munniksma, A.; Juvonen, J.

    2012-01-01

    This exploratory study examined whether cross-ethnic friendships are related to students’ sense of social-emotional safety in a multiethnic middle school. The analysis sample (n = 227) consisted of Latino (57%) and White (43%) sixth- and seventh-grade students. Although a strong preference for same-

  5. Determinants of clearance of human papillomavirus infections in Colombian women with normal cytology: a population-based, 5-year follow-up study.

    NARCIS (Netherlands)

    Molano, M; Brule, den A Van; Plummer, M; Weiderpass, E; Posso, H; Arslan, A; Meijer, C.J.L.M.; Munoz, N.; Franceschi, S

    2003-01-01

    Little is known about the factors that influence clearance of human papillomavirus (HPV), the primary cause of cervical carcinoma. A total of 227 women cytologically normal and HPV positive at baseline were identified from a population-based cohort of 1,995 Bogota, Colombia, women aged 13-85 years f

  6. Theoretical Advanced Study Institute: 2014

    Energy Technology Data Exchange (ETDEWEB)

    DeGrand, Thomas [Univ. of Colorado, Boulder, CO (United States)

    2016-08-17

    The Theoretical Advanced Study Institute was held at the University of Colorado, Boulder, during June 2-27, 2014. The topic was "Journeys through the Precision Frontier: Amplitudes for Colliders." The organizers were Professors Lance Dixon (SLAC) and Frank Petriello (Northwestern and Argonne). There were fifty one students. Nineteen lecturers gave sixty seventy five minute lectures. A Proceedings was published.

  7. Kirjad vallutatud Hiinast / Karl Rumor

    Index Scriptorium Estoniae

    Rumor, Karl, pseud., 1886-1971

    2008-01-01

    1937. a. alanud Hiina-Jaapani sõjast, poliitlistest oludest ja revolutsioonist Hiinas, hiinlastest ja Hiina suhetest teiste riikidega. Varem ilmunud: Uus Eesti 19.-20. aug, 1938, nr. 226-227; 12.-13., 16. sept. 1938, nr. 250-251, 254

  8. Examining the Construct Validity of the Elemental Psychopathy Assessment

    Science.gov (United States)

    Miller, Joshua D.; Gaughan, Eric T.; Maples, Jessica; Gentile, Brittany; Lynam, Donald R.; Widiger, Thomas A.

    2011-01-01

    Lynam and colleagues recently developed a new self-report inventory for the assessment of psychopathy, the Elemental Psychopathy Assessment (EPA). Using a sample of undergraduates (N = 227), the authors examined the construct validity of the EPA by examining its correlations with self and stranger ratings on the Five-Factor Model, as well as…

  9. Mothers' Speech in Three Social Classes

    Science.gov (United States)

    Snow, C. E.; And Others

    1976-01-01

    Functional and linguistic aspects of the speech of Dutch-speaking mothers from three social classes to their two-year-old children were studied to test the hypothesis that simplified speech is crucial to language acquisition. Available from Plenum Publishing Corp., 227 W. 17th St., New York, NY 10011. (Author/RM)

  10. Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Sandra Witz

    Full Text Available Plastidic uracil salvage is essential for plant growth and development. So far, PLUTO, the plastidic nucleobase transporter from Arabidopsis thaliana is the only known uracil importer at the inner plastidic membrane which represents the permeability barrier of this organelle. We present the first homology model of PLUTO, the sole plant NCS1 member from Arabidopsis based on the crystal structure of the benzyl hydantoin transporter MHP1 from Microbacterium liquefaciens and validated by molecular dynamics simulations. Polar side chains of residues Glu-227 and backbones of Val-145, Gly-147 and Thr-425 are proposed to form the binding site for the three PLUTO substrates uracil, adenine and guanine. Mutational analysis and competition studies identified Glu-227 as an important residue for uracil and to a lesser extent for guanine transport. A differential response in substrate transport was apparent with PLUTO double mutants E227Q G147Q and E227Q T425A, both of which most strongly affected adenine transport, and in V145A G147Q, which markedly affected guanine transport. These differences could be explained by docking studies, showing that uracil and guanine exhibit a similar binding mode whereas adenine binds deep into the catalytic pocket of PLUTO. Furthermore, competition studies confirmed these results. The present study defines the molecular determinants for PLUTO substrate binding and demonstrates key differences in structure-function relations between PLUTO and other NCS1 family members.

  11. Breeding of an anti-postacidification strain from Lactobacillus bulgaricus by NTG mutagenesis%抗后酸化保加利亚乳杆菌的亚硝基胍诱变选育

    Institute of Scientific and Technical Information of China (English)

    车黎猛; 任发政; 张恒涛; 常征; 蔡华伟

    2006-01-01

    利用0.9mg/mL亚硝基胍对保加利亚乳杆菌ZLB进行诱变处理30min(菌株致死率为99%),中间培养后用青霉素筛选.处理液涂布培养后,选取生长缓慢或不长的32株接种于RSM(Reconstituted Skimmed Milk)培养基中,随后选取凝固的16株做12℃贮藏,最终得到产酸较慢的突变株ZT224、ZT227.突变株与ZLB相比,在42℃时,ZT224、ZT227在RSM培养基中滴定酸度值明显减少.发酵脱脂乳在12℃贮藏时,ZT224的发酵乳在贮藏的20d内一直没有发生后酸化;ZT227发生后酸化的时间推迟了4d.同时,突变株ZT224、ZT227对链霉素的敏感性不同于出发菌株ZLB且能稳定遗传.

  12. 24 CFR 35.315 - Risk assessment.

    Science.gov (United States)

    2010-04-01

    ... Provided by a Federal Agency Other Than HUD § 35.315 Risk assessment. Each owner shall complete a risk assessment in accordance with 40 CFR 745.227(d). Each risk assessment shall be completed in accordance with... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Risk assessment. 35.315 Section...

  13. 48 CFR 970.2702-2 - Notice and assistance regarding patent and copyright infringement.

    Science.gov (United States)

    2010-10-01

    ... Infringement, instead of the clause at 48 CFR 52.227-2. ... regarding patent and copyright infringement. 970.2702-2 Section 970.2702-2 Federal Acquisition Regulations... Patents, Data, and Copyrights 970.2702-2 Notice and assistance regarding patent and copyright...

  14. A comparison between composition and density of the fat-free mass of young adult Singaporean Chinese and Dutch Caucasians

    NARCIS (Netherlands)

    Werkman, A.; Deurenberg-Yap, M.; Schmidt, G.; Deurenberg, P.

    2000-01-01

    The body composition was measured in 30 female Singapore Chinese and 34 female Dutch Caucasians aged (mean ± SD) 22.7 ± 3.6 years and in 39 male Singapore Chinese and 39 male Dutch Caucasians aged 23.3 ± 3.2 years. Methods: The body fat percentage (BF€was measured using densitometry and deuterium ox

  15. AcEST: BP913315 [AcEST

    Lifescience Database Archive (English)

    Full Text Available rotein C1orf198 OS=Homo s... 30 6.7 sp|P03123|VE2_PAPVD Probable regulatory protein E2 OS=Deer papil... 29 8...21 GEKVLPP 227 >sp|P03123|VE2_PAPVD Probable regulatory protein E2 OS=Deer papillomavirus GN=E2 PE=3 SV=2 Le

  16. Cold temperature disinfestation of bagged flour

    Science.gov (United States)

    We conducted studies using a commercial freezer maintained at -17.8°C to determine the time needed to kill Tribolium castaneum eggs in a pallet of flour. Each bag weighed 22.7 kg, and there were 5 bags in each of 10 layers. The dimensions of the pallet were 109-cm wide by 132-cm long by 123-cm tall,...

  17. Investigating Factors in the Retention of Students in High School Physical Education

    Science.gov (United States)

    Lodewyk, Ken R.; Pybus, Colin M.

    2013-01-01

    Several studies have reported declining student enrolment rates in optional physical education. This study--incorporating constructs from social cognitive, self-determination, and body image theory--investigated factors that might be influential to this trend. Surveys were administered to 227 tenth-grade students from five schools in one school…

  18. 50 CFR 216.270 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... pings per dip) (v) SSQ-62 (Directional Command Activated Sonobuoy System (DICASS) sonobuoys)—up to 21275 sonobuoys over the course of 5 years (an average of 4255 sonobuoys per year) (vi) MK-48 (heavyweight... average of 227 hours per year) (x) AN/SSQ-125 (AEER sonar sonobuoy)—up to 540 sonobuoys (total, of...

  19. Work-Family Conflict, Resources, and Role Set Density: Assessing Their Effects on Distress among Working Mothers

    Science.gov (United States)

    Kulik, Liat; Liberman, Gabriel

    2013-01-01

    We explored the relationships between the experience of work-family conflict and levels of distress in the family and at work among a sample of 227 Israeli working mothers. We also examined how role set density (RSD, the number of roles they perform) and personal and environmental resources are related to the women's experience of distress.…

  20. Rose Atoll Site 29P 7/31/2004 27-28M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 29P (14 32.227S, 168 09.122W), between 27 and 28 meters along a permanent transect.

  1. 78 FR 65190 - Airworthiness Directives; Bombardier, Inc. Airplanes

    Science.gov (United States)

    2013-10-31

    ... bec H4S 1Y9, Canada; telephone 514-855-5000; fax 514-855-7401; email thd.crj@aero.bombardier.com... this material at the FAA, call 425- 227-1221. FOR FURTHER INFORMATION CONTACT: Cesar Gomez, Aerospace.... SUPPLEMENTARY INFORMATION: Discussion We issued a notice of proposed rulemaking (NPRM) to amend 14 CFR part...

  2. 75 FR 51105 - Proposed Finding Against Federal Acknowledgment of the Central Band of Cherokee

    Science.gov (United States)

    2010-08-18

    ... Bureau of Indian Affairs Proposed Finding Against Federal Acknowledgment of the Central Band of Cherokee... group known as the ``Central Band of Cherokee'' (CBC), Petitioner 227, c/o Mr. Joe H. White, 1 Public... members are descendants of Cherokee Indians who had not given up their rights to lands in Tennessee...

  3. Bilingualism and Mathematics Learning: Another Perspective.

    Science.gov (United States)

    Clarkson, Philip C.; Galbraith, Peter

    1992-01-01

    The influence of English, the language used in the schooling of 227 sixth graders from Papua New Guinea, as well as the influence of their native language, Pidgin, were both found to have a significant impact upon their mathematical performance. (41 references) (JJK)

  4. 10 CFR Appendix D to Part 835 - Surface Contamination Values

    Science.gov (United States)

    2010-01-01

    ... + Removable) 2,3 U-nat, U-235, U-238, and associated decay products 7 1,000 7 5,000 Transuranics, Ra-226, Ra-228, Th-230, Th-228, Pa-231, Ac-227, I-125, I-129 20 500 Th-nat, Th-232, Sr-90, Ra-223, Ra-224,...

  5. 78 FR 65936 - Endangered and Threatened Wildlife and Plants; Proposed Endangered Status for Gunnison Sage...

    Science.gov (United States)

    2013-11-04

    ... sage-grouse as endangered (78 FR 2486) and a proposed rule to designate critical habitat for the Gunnison sage-grouse (78 FR 2540). We proposed to designate as critical habitat approximately 1,704,227... section for our proposal to designate critical habitat for the Gunnison sage-grouse (78 FR 57604). In...

  6. Toddlers' Adjustment to the Stress of Immunization in Function of Mothers' General and Specific Coping Tendencies

    Science.gov (United States)

    Favez, N.; Reicherts, M.

    2008-01-01

    The aim of this research is to assess the relative influence of mothers' coping strategies in everyday life and mothers' specific coping acts on toddlers' adjustment behavior to pain and distress during a routine immunization. The population is 41 mothers with toddlers (23 girls, 18 boys; mean age, 22.7 months) undergoing a routine immunization in…

  7. Get Tested for Colon Cancer: Here's How

    Medline Plus

    Full Text Available How can we help you? Search Live Chat 800-227-2345 Home Learn About Cancer Stay Healthy Find Support & Treatment Explore ... with a part of the body that’s, shall we say, not easy to talk about. Well, the ...

  8. 77 FR 27113 - Export and Import of Nuclear Equipment and Material; Export of International Atomic Energy Agency...

    Science.gov (United States)

    2012-05-09

    ... export uranium or thorium, other than uranium-230, uranium-232, thorium-227, or thorium-228, in... country when the uranium or thorium is Canadian-obligated. * * * * * 0 4. In Sec. 110.27, revise paragraph...) so that the reference is to paragraph (e) of the section instead of to paragraph (f). Section...

  9. Domain Modeling: NP_003411.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_003411.3 chr3 CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA c1meyf_ chr3/NP_003411.3.../NP_003411.3_holo_219-301.pdb blast 224C,226V,227C,228G,229K,230G,231F,232S,233Q,234S

  10. Enzyme-linked immunosorbent assay using a virus type-specific peptide based on a subdomain of envelope protein e(rns) for serologic diagnosis of pestivirus infections in swine

    NARCIS (Netherlands)

    Langedijk, J.P.; Middel, W.G.; Meloen, R.H.; Kramps, J.A.; Smit, de J.A.

    2001-01-01

    Peptides deduced from the C-terminal end (residues 191 to 227) of pestivirus envelope protein Erns were used to develop enzyme-linked immunosorbent assays (ELISAs) to measure specifically antibodies against different types of pestiviruses. The choice of the peptide was based on the modular structure

  11. High-resolution absorption measurements of NH3 at high temperatures: 500–2100cm−1

    DEFF Research Database (Denmark)

    Barton, Emma J.; Yurchenko, Sergei N.; Tennyson, Jonathan;

    2015-01-01

    temperature gas flow cells using a FourierTransform Infrared (FTIR) spectrometer at a nominal resolution of 0.09cm-1. Measurements at 22.7 °C are compared to high-resolution cross sections available from thePacific Northwest National Laboratory (PNNL). The higher temperature spectra are analysed by comparison...

  12. Resistant to the Message: Are Pupils Unreceptive to Teachers' Anti-Bullying Initiatives and If so Why?

    Science.gov (United States)

    Boulton, Michael J.; Boulton, Richard

    2012-01-01

    Despite three decades of research and development of anti-bullying intervention, this form of systematic aggression continues to be common in schools. The present study investigated if a contributing factor might be that some pupils are unreceptive to teachers' anti-bullying lessons. It invited 8-11-year-old junior school pupils (N = 227) to…

  13. File list: ALL.Myo.10.AllAg.Myotube [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Myo.10.AllAg.Myotube mm9 All antigens Muscle Myotube SRX497486,SRX497487,SRX227...232,SRX497488,SRX236484,SRX227230,SRX497489 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Myo.10.AllAg.Myotube.bed ...

  14. Reference: AT1BOX [PLACE

    Lifescience Database Archive (English)

    Full Text Available AT1BOX Ueda T, Pichersky E, Malik VS, Cashmore AR The level of expression of the to...mato rbcs-3A gene is modulated by a far-upstream promoter element in a developmentary regulated manner. Plant Cell 1:217-227 (1989) PubMed: 2535544; GenBank: S44160; ...

  15. An Exploration of School Counselors' Demands and Resources: Relationship to Stress, Biographic, and Caseload Characteristics

    Science.gov (United States)

    McCarthy, Christopher; Kerne, Valerie Van Horn; Calfa, Nicolina A.; Lambert, Richard G.; Guzman, Michele

    2010-01-01

    The study in this article examined the relationship of school counselors' reports of demands and resources in their work environment to perceived stress, biographic factors, and caseload characteristics. Participants were 227 school counselors in Texas. Paperwork requirements and size of caseload were rated the most demanding aspects of their job,…

  16. Dicty_cDB: CHG384 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 2 3e-36 AF268611_12( AF268611 |pid:none) Uncultured marine group II euryar... 34 1.6 D43959_1( D43959 |pid:none) Thiobacillus thiooxi...dans plasmid pTTY1... 33 4.7 CR382125_227( CR382125 |pid:none) Kluyveromyces lactis

  17. Beyond Good Intentions: The effectiveness of a proactive self-management intervention in patients with screen-detected type 2 diabetes

    NARCIS (Netherlands)

    Thoolen, B.J.

    2007-01-01

    This prospective randomized controlled trial evaluated a theory-driven group-based self-management course for patients with screen-detected type 2 diabetes. 227 patients receiving either intensive pharmacological or usual-care treatment since diagnosis (3-33 months previously) agreed to participate

  18. Martin Creed: "Tahan luua keskkonna, kus on hea olla" / intervjueerinud Maria Arusoo

    Index Scriptorium Estoniae

    Creed, Martin, 1968-

    2011-01-01

    Tallinna Kunstihoones 29. sept.-l publikuga kohtunud inglise kunstnik, muusik ja teoreetik Martin Creed endast, oma loomingust, loomeprotsessist, oma Turner Prize'i pälvinud installatsioonist "Work No 227. Lights going on and off", mis oli väljas näitusel "Continuum_Kunst kui taju. Ruum kui protsess" jm.

  19. Characterization of hydraulic nozzles for droplet size and spray coverage

    Science.gov (United States)

    Spray coverage specifications for commercially available nozzles could help applicators determine the optimal nozzles for effective control of insects, diseases and weeds. Spray coverage and deposit density from seven types of nozzles at three different flow rates (0.76, 1.14 and 2.27 l min-1) and t...

  20. 45 CFR 170.299 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... CFR part 51. To enforce any edition other than that specified in this section, the Department of... available from the sources listed below. (b) Health Level Seven, 3300 Washtenaw Avenue, Suite 227, Ann Arbor....5 Message Structure Specification for National Condition Reporting Final Version 1.0,...

  1. In the Aftermath of Unz.

    Science.gov (United States)

    Herrera, Socorro; Murry, Kevin G.

    1999-01-01

    Analyzes three public controversies related to California's Proposition 227: English as endangered language versus students' right to appropriate education, bilingual education versus structured English immersion, and local control and professional volition versus state-mandated English-only education. Outlines an advocacy framework applicable to…

  2. Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study

    OpenAIRE

    Franklin, Donald R.; Deutsch, Reena; Casaletto, Kaitlin; Marquine, Maria J.; Woods, Steven P.; Collier, Ann C; Marra, Christina M.; Clifford, David B.; Gelman, Benjamin B.; Sacktor, Ned; Simpson, David M.; Grant, Igor; Franklin, Donald; ELLIS, Ronald J.; Alexander, Terry

    2014-01-01

    CNS HIVAnti-Retroviral Therapy Effects Research examined incidence and predictors of neurocognitive (NC) change in 436 human immunodeficiency virus (HIV)-infected adults over 4–7 semiannual visits; 22.7% evidenced NC decline and 16.5% NC improvement. These changes were predicted by HIV disease and treatment factors, demographics, and comorbid conditions.

  3. Disease: H00503 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available hanet J Rare Dis 2:27 (2007) PMID:19876929 (description, gene) Ruiz-Perez VL, Goodship JA Ellis-van Creveld ... Dallapiccola B, Wright M, Meitinger T, Polymeropoulos MH, Goodship J Mutations in a new gene in Ellis-van C

  4. AcEST: BP915100 [AcEST

    Lifescience Database Archive (English)

    Full Text Available t : Swiss-Prot sp_hit_id O61308 Definition sp|O61308|PUMA_PARUN 227 kDa spindle- and centromere-associated protein OS=Parascaris...dle- and centromere-associated protein OS=Parascaris univalens GN=PUMA1 PE=2 SV=1 Length = 1955 Score = 44.7

  5. 40 CFR 60.296 - Test methods and procedures.

    Science.gov (United States)

    2010-07-01

    ... production rate correction =227 g/hr for container glass, pressed and blown (soda-lime and lead) glass, and pressed and blown (other than borosilicate, soda-lime, and lead) glass. =454 g/hr for pressed and blown... (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for...

  6. Sweetened beverages

    Science.gov (United States)

    ... calories. A 20-ounce bottle of non-diet soda has 227 calories. A 16-ounce glass of sweetened ice tea has 180 calories. A ... choices that have 0 calories are: Water Diet soda Sparkling water with natural flavors, such as lemon, lime, and berry Plain coffee or tea

  7. 48 CFR 970.5227-2 - Rights in data-technology transfer.

    Science.gov (United States)

    2010-10-01

    ... 48 CFR 970.2704-3(b), insert the following clause: Rights in Data—Technology Transfer (DEC 2000) (a... vest in the author thereof, subject to the right of DOE to retain duplicates of such documents and to... 927.409, the clause entitled, “Rights in Data-General” at 48 CFR 52.227-14 modified in accordance...

  8. Prokinetic Therapy Reduces Aspiration Pneumonia in Tube-Fed Patients With Severe Developmental Disabilities

    Science.gov (United States)

    Pareek, Namita; Williams, John; Hanna, Deborah; Johnson, William D.; Minocha, Anil; Abell, Thomas L.

    2007-01-01

    To evaluate the clinical benefit of prokinetic therapy in aspiration pneumonia in patients with developmental disabilities, we conducted a retrospective study; records of 22 tube-fed patients were reviewed from December 1990 to October 1998 for a mean of 22.7 months before and 38.9 months during Cisapride therapy. Numbers of hospital admissions…

  9. PALEONTOLOGY

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>20142263Lü Shaojun(Geological Survey of Jiangxi Province,Nanchang 330030,China)Early-Middle Permian Biostratigraphical Characteristics in Qiangduo Area,Tibet(Resources Survey&Environment,ISSN1671-4814,CN32-1640/N,34(4),2013,p.221-227,2illus.,2tables,22refs.)Key words:biostratigraphy,Lower Permian,Middle Permian,Tibet

  10. 21 CFR 520.928 - Firocoxib tablets.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Firocoxib tablets. 520.928 Section 520.928 Food... DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.928 Firocoxib tablets. (a) Specifications. Each chewable tablet contains 57 or 227 milligrams (mg) firocoxib. (b) Sponsor. See No. 050604...

  11. On a Method of Statistical Business-Cycle Research; a reply (to Keynes)

    NARCIS (Netherlands)

    J. Tinbergen (Jan)

    1940-01-01

    textabstractAlso published in: A.H. Hansen and R.V. Clemence (Eds), Readings on Business Cycles and National Income, Allen & Unwin, London, 1953, pp. 341-354, in: Adrian C. Darnell (Ed), The History of Econometrics Vol. 2, Edward Elgar, Aldershot, 1994, pp. 214-227 and in: Dale J. Poirier (Ed), The

  12. Classifying Korean Adolescents' Career Preparedness

    Science.gov (United States)

    Lee, In Heok; Rojewski, Jay W.; Hill, Roger B.

    2013-01-01

    Latent class analysis was used to examine the career preparation of 5,227 11th-grade Korean adolescents taken from the Korean Education Longitudinal Study of 2005 (KELS:2005). Three career preparedness groups were identified, to reflecting Skorikov's ("J Vocat Behav" 70:8-24, 2007) conceptualization of career preparedness: prepared, confused, and…

  13. Relationships of Social Context and Identity to Problem Behavior among High-Risk Hispanic Adolescents

    Science.gov (United States)

    Schwartz, Seth J.; Mason, Craig A.; Pantin, Hilda; Wang, Wei; Brown, C. Hendricks; Campo, Ana E.; Szapocznik, Jose

    2009-01-01

    The present study was designed to examine (a) family and school functioning and (b) personal and ethnic identity are associated with conduct problems, drug use, and sexual risk taking in a sample of 227 high-risk Hispanic adolescents. Adolescents participated in the study with their primary parents, who were mostly mothers. Adolescents completed…

  14. Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations

    OpenAIRE

    Micol, Jean-Baptiste; Duployez, Nicolas; Boissel, Nicolas; Petit, Arnaud; Geffroy, Sandrine; Nibourel, Olivier; Lacombe, Catherine; Lapillonne, Helene; Etancelin, Pascaline; Figeac, Martin; Renneville, Aline; Castaigne, Sylvie; Leverger, Guy; Ifrah, Norbert; Dombret, Hervé

    2014-01-01

    ASXL2 was mutated in 22.7% (25/110) of adult and pediatric t(8;21)/RUNX1-RUNX1T1 acute myeloid leukemia patients.ASXL2 mutations are mutually exclusive with ASXL1 mutations and occur in t(8;21) but not inv(16)/t(16;16) or RUNX1-mutant AML.

  15. AcEST: BP915657 [AcEST

    Lifescience Database Archive (English)

    Full Text Available Aspartate-semialdehyde dehydrogenase OS=Met... 31 3.1 sp|O15164|TIF1A_HUMAN Transcription intermediary fact...YKDACYWFQDRDIPENIKDMVVIPTDPKHEEFEDVDIVFSALPSDLA 96 Query: 227 R 229 + Sbjct: 97 K 97 >sp|O15164|TIF1A_HUMAN Transcription intermediar

  16. the potential for enhancement of immunity in cats by dietary supplementation

    NARCIS (Netherlands)

    Rutherfurd-Markwick, K.J.; Hendriks, W.H.; Morel, P.C.H.; Thomas, D.G.

    2013-01-01

    This study was conducted to examine the potential benefits of dietary supplementation on the feline immune system. Forty three cats (8 or 9 per group) were fed a low protein control diet (22.7% DM basis), the same diet supplemented with yeast-derived nucleotides, salmon oil or l-arginine or a commer

  17. Description of the male sex of HElota attenuata Rits

    NARCIS (Netherlands)

    Ritsema Cz., C.

    1913-01-01

    Helota attenuata belongs, together with Dureli, Moutoni and Helleri, to the group of Helota rotundata (see my „Synopsis” in Notes Leyd. Mus. Vol. XIII, p. 227). It is easily recognizable among these species by the coarse punctuation on the pronotum and by the reddish testaceous colour of the elytral

  18. Rose Atoll Site 29P 3/9/2006 5-6M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Rose Atoll, site 29P 14 32.227S, 168 09.122W, between 5 and 6 meters along a permanent transect.

  19. Drug: D01333 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01333 Drug Urapidil (JP16/INN); Ebrantil (TN) C20H29N5O3 387.227 387.476 D01333.gif Antihypertensive...vascular agents 214 Antihypertensives 2149 Others D01333 Urapidil (JP16/INN) 25 U...tagonists Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardio

  20. SENSITIVITY OF AN INFAUNAL AMPHIPOD, EOHAUSTORIUS ESTUARIUS, TO ACUTE WATER-BORN EXPOSURES OF 4-NONYLPHENOL (NP): EVIDENCE OF A TOXIC HANGOVER

    Science.gov (United States)

    Three independent trials were conducted using mortality and burial as endpoints. Mean LC50 was 227 ug/l. One hour burial as a sub-lethal endpoint increased the sensitivity of the toxicity test by 40%; however most amphipods that survived exposure were able to recover within 24-48...

  1. A new analysis of a simple model of fair allocation

    OpenAIRE

    Juan D. Moreno-Ternero

    2012-01-01

    In a recent article, Fragnelli and Gagliardo [Cooperative models for allocating an object, Economics Letters 117 (2012) 227-229] propose several procedures to solve a basic problem of fair allocation. We scrutinize their proposal and contextualize it into recent developments of the literature on bankruptcy problems. Our analysis supports two of the procedures they propose; namely, the Shapley and Talmud rules.

  2. FastStats: Leading Causes of Death

    Science.gov (United States)

    ... • Accidents (unintentional injuries): 136,053 • Stroke (cerebrovascular diseases): 133,103 • Alzheimer's disease: 93,541 • Diabetes: 76,488 • Influenza and pneumonia: 55,227 ...

  3. Selective Exposure to Televised Aggression. Report No. 7.

    Science.gov (United States)

    Atkin, Charles K.; And Others

    This 2-wave panel survey of young people was conducted to explore the relationship between attitudes and viewing over time, examining aggressiveness and viewing of programs portraying physical and verbal aggression. Questionnaires were administered to 227 children in the fourth, sixth, and eighth grades in 1976 and again one year later. The…

  4. Down and drowsy? Do apathetic nursing home residents experience low quality of life?

    NARCIS (Netherlands)

    Gerritsen, DL; Jongenelis, K; Steverink, N; Ooms, ME; Ribbe, MW

    2005-01-01

    This cross-sectional study investigated the relationship between apathy and quality of life (QOL) in nursing home residents (n = 227). In all, 92 residents could be assessed with the Mini Mental State Examination (MMSE), the Geriatric Depression Scale (GDS) and the Philadelphia Geriatric Centre Mora

  5. 32 CFR Appendix A to Part 518 - References

    Science.gov (United States)

    2010-07-01

    ... Patents, Data, and Copyrights. See also 48 CFR part 227; (24) Department of Defense Financial Management... and Penalty on Claims; (47) 32 CFR part 518, The Army FOIA Program; (48) 35 U.S.C. 181-188, Secrecy of... of Records; (52) 45 CFR part 164, Security and Privacy of Individually Identifiable...

  6. The diamond and other non-conventional morphologies in two-scale multiblock AB copolymers

    NARCIS (Netherlands)

    Erukhimovich, Igor; Kriksin, Yury; ten Brinke, Gerrit

    2012-01-01

    We revisit the idea of the existence of the ordered block copolymer phase possessing diamond symmetry Fd (3) over barm (space group No. 227), which was first put forward within the framework of the strong segregation approach. For this purpose we study the order-disorder and order-order transitions

  7. 78 FR 39633 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2013-07-02

    ..., Amendment 39-8129 (57 FR 781, January 9, 1992). If delamination and/or physical damage are found as a result... availability of this material at the FAA, call 425-227-1221. Examining the AD Docket You may examine the AD...-23-06, Amendment 39-6794 (55 FR 46499, November 5, 1990), for certain Boeing Model 757...

  8. File list: ALL.Myo.20.AllAg.Myotube [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Myo.20.AllAg.Myotube mm9 All antigens Muscle Myotube SRX497486,SRX497487,SRX227...232,SRX497488,SRX236484,SRX497489,SRX227230 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Myo.20.AllAg.Myotube.bed ...

  9. 77 FR 68196 - Orders Limiting Operations at John F. Kennedy International Airport, LaGuardia Airport, and...

    Science.gov (United States)

    2012-11-15

    ... CFR 93.227 (DCA); 74 FR 51648 (Oct. 7, 2009) (EWR); 74 FR 51650 (Oct. 7, 2009) (JFK); 77 FR 30585 (May... Authorizations (slots) at John F. Kennedy International Airport (JFK), LaGuardia Airport (LGA), and Newark... occurred at slot-controlled and non- slot-controlled airports. JFK and EWR were effectively closed...

  10. Antecedents of Norwegian Beginning Teachers' Turnover Intentions

    Science.gov (United States)

    Tiplic, Dijana; Brandmo, Christian; Elstad, Eyvind

    2015-01-01

    This study aims at exploring several individual, organizational, and contextual factors that may affect beginning teachers' turnover intentions during their first years of practice. The sample consists of 227 beginning teachers (69% female and 31% male) from 133 schools in Norway. The results show four important antecedents of beginning teachers'…

  11. Renovation of the outside lighting - Bldg. 112 zone

    CERN Multimedia

    GS Department

    2010-01-01

    Due to the renovation of the outside lighting, the traffic will be disrupted along “Route Feynman”. From the water tower (Bldg. 227) to Restaurant Nr. 2 (Bldg. 504) between 18 and 30 August. We recommend great caution. Thank you for your understanding. SEM Group

  12. 75 FR 9017 - Orders Limiting Scheduled Operations at John F. Kennedy International Airport, LaGuardia Airport...

    Science.gov (United States)

    2010-02-26

    ... CFR Sec. 93.227 (DCA); 74 FR 51648 (Oct. 7, 2009) (EWR); 74 FR 51650 (Oct. 7, 2009) (JFK); 74 FR 51653... Airport, LaGuardia Airport and Newark Liberty International Airport; High Density Rule at Reagan National Airport AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of limited waiver of the...

  13. 76 FR 19517 - Orders Limiting Scheduled Operations at John F. Kennedy International Airport, LaGuardia Airport...

    Science.gov (United States)

    2011-04-07

    ....\\1\\ \\1\\ 75 FR 9017 (Feb. 26, 2010). ATA also stated the National Oceanic and Atmospheric...\\ 14 CFR 93.227 (DCA); 74 FR 51648 (Oct. 7, 2009) (EWR); 74 FR 51650 (Oct. 7, 2009) (JFK); 74 FR 51653... Airport, LaGuardia Airport, and Newark Liberty International Airport; High Density Rule at Reagan...

  14. Predictors of Job Tenure for New Hires with Mental Retardation.

    Science.gov (United States)

    Pierce, Kristen; McDermott, Suzanne; Butkus, Stanley

    2003-01-01

    In South Carolina, 10,169 individuals with mental retardation were served by the state disability agency and 22.7% were employed during 1997-2000, with 68% keeping their job for more than 1 year. Food service, manufacturing, disability services, grocery, and retail companies employed the majority of those who worked at least 3 years. (Contains…

  15. How the Attachment Styles Associated with Student Alienation: The Mediation Role of Emotional Well-Being

    Science.gov (United States)

    Kocayörük, Ercan; Uzman, Ersin; Mert, Abdullah

    2014-01-01

    The present study examined emotional well-being as a mediator between parental attachment (mother and father) and student alienation. A total of 227 high school students from the city of Ankara completed the self-report measures of parental attachment, positive and negative affect, and alienation. Using structural equation modeling, a model was…

  16. Cardiovascular end-organ damage in Ren-2 transgenic rats compared to spontaneously hypertensive rats

    NARCIS (Netherlands)

    Pinto, YM; Buikema, H; vanGilst, WH; vanGeel, PP; deGraeff, PA; Wagner, J; Paul, M

    1997-01-01

    To compare hypertensive end-organ damage in two genetic forms of hypertension we assessed cardiovascular function in two rat strains of generic hypertension: transgenic rats overexpressing the mouse Ren-2 gene [(TGR(mREN2)27]) and blood pressure matched spontaneously hypertensive rats (SHR). Despite

  17. Alternativ behandling i Danmark--brug, brugere og årsager til brug

    DEFF Research Database (Denmark)

    Lønroth, Helle Langhoff; Ekholm, Ola

    2006-01-01

    : The survey revealed that 40.2% had ever used CAM and 20.1% had used CAM within the last year. Of those reporting having used CAM ever, reflexology (22.7%), massage/osteopathy/other manipulative techniques (16.5%) and acupuncture (16.2%) were the most frequently used. The use of CAM was more common among...

  18. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization.

    Directory of Open Access Journals (Sweden)

    Jaspreet Singh Jaggi

    Full Text Available BACKGROUND: Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen and drug delivery and results in radiotherapy and chemotherapy resistance, respectively. Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature. METHODOLOGY AND PRINCIPAL FINDINGS: Actinium-225 ((225Ac-E4G10, an alpha-emitting antibody construct reactive with the unengaged form of vascular endothelial cadherin, is capable of potent, selective killing of tumor neovascular endothelium and late endothelial progenitors in bone-marrow and blood. No specific normal-tissue uptake of E4G10 was seen by imaging or post-mortem biodistribution studies in mice. In a mouse-model of prostatic carcinoma, (225Ac-E4G10 treatment resulted in inhibition of tumor growth, lower serum prostate specific antigen level and markedly prolonged survival, which was further enhanced by subsequent administration of paclitaxel. Immunohistochemistry revealed lower vessel density and enhanced tumor cell apoptosis in (225Ac-E4G10 treated tumors. Additionally, the residual tumor vasculature appeared normalized as evident by enhanced pericyte coverage following (225Ac-E4G10 therapy. However, no toxicity was observed in vascularized normal organs following (225Ac-E4G10 therapy. CONCLUSIONS: The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy.

  19. Determination of radium in water

    International Nuclear Information System (INIS)

    These detailed work instructions (DWIs) are tailored for the analysis of radium-226 and radium-228 in drinking water supplies from ground water and surface water sources and composites derived from them. The instructions have been adapted from several sources, including a draft EPA method. One objective was to minimize the generation of mixed wastes. Quantitative determinations of actinium-228 are made at 911 keV. The minimum detection level (MDL) for the gamma spectrometric measurements at this energy vary with matrix, volume, geometry, detector, background, and counting statistics. The range of MDL's for current detectors is 0.07 to 0.5 Bq/sample. Quantitative determinations of radium-226 are made by counting the high energy alpha particles which radium-226 progeny emit using liquid scintillation counting (LSC). The minimum detectable activity (MDA) is 3.8 E-3 Bq/sample. The maximum concentration which may be counted on available instruments without dilution is about 2 E + 5 Bq/sample. Typically, this determination of radium in a 2 L sample has a yield of 80%. If radium-228 is determined using a 16 h count after 50 h grow-in, the typical MDL is 1 E-9 to 8 E-9 μCi/mL (1 to 8 pCi/L). If radium-226 is determined using a 2.5 h count after 150 h grow-in, the typical MDA is about 1 E-10 μCi/mL (0. 1 pCi/L)

  20. Determination of radium in water

    Energy Technology Data Exchange (ETDEWEB)

    Hohorst, F.A.; Huntley, M.W.; Hartenstein, S.D.

    1995-10-01

    These detailed work instructions (DWIs) are tailored for the analysis of radium-226 and radium-228 in drinking water supplies from ground water and surface water sources and composites derived from them. The instructions have been adapted from several sources, including a draft EPA method. One objective was to minimize the generation of mixed wastes. Quantitative determinations of actinium-228 are made at 911 keV. The minimum detection level (MDL) for the gamma spectrometric measurements at this energy vary with matrix, volume, geometry, detector, background, and counting statistics. The range of MDL`s for current detectors is 0.07 to 0.5 Bq/sample. Quantitative determinations of radium-226 are made by counting the high energy alpha particles which radium-226 progeny emit using liquid scintillation counting (LSC). The minimum detectable activity (MDA) is 3.8 E-3 Bq/sample. The maximum concentration which may be counted on available instruments without dilution is about 2 E + 5 Bq/sample. Typically, this determination of radium in a 2 L sample has a yield of 80%. If radium-228 is determined using a 16 h count after 50 h grow-in, the typical MDL is 1 E-9 to 8 E-9 {mu}Ci/mL (1 to 8 pCi/L). If radium-226 is determined using a 2.5 h count after 150 h grow-in, the typical MDA is about 1 E-10 {mu}Ci/mL (0. 1 pCi/L).