WorldWideScience

Sample records for actinium 225

  1. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  2. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  3. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  4. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the

  5. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  6. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  7. Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

    Science.gov (United States)

    Radchenko, V; Engle, J W; Wilson, J J; Maassen, J R; Nortier, F M; Taylor, W A; Birnbaum, E R; Hudston, L A; John, K D; Fassbender, M E

    2015-02-06

    Actinium-225 (t1/2=9.92d) is an α-emitting radionuclide with nuclear properties well-suited for use in targeted alpha therapy (TAT), a powerful treatment method for malignant tumors. Actinium-225 can also be utilized as a generator for (213)Bi (t1/2 45.6 min), which is another valuable candidate for TAT. Actinium-225 can be produced via proton irradiation of thorium metal; however, long-lived (227)Ac (t1/2=21.8a, 99% β(-), 1% α) is co-produced during this process and will impact the quality of the final product. Thus, accurate assays are needed to determine the (225)Ac/(227)Ac ratio, which is dependent on beam energy, irradiation time and target design. Accurate actinium assays, in turn, require efficient separation of actinium isotopes from both the Th matrix and highly radioactive activation by-products, especially radiolanthanides formed from proton-induced fission. In this study, we introduce a novel, selective chromatographic technique for the recovery and purification of actinium isotopes from irradiated Th matrices. A two-step sequence of cation exchange and extraction chromatography was implemented. Radiolanthanides were quantitatively removed from Ac, and no non-Ac radionuclidic impurities were detected in the final Ac fraction. An (225)Ac spike added prior to separation was recovered at ≥ 98%, and Ac decontamination from Th was found to be ≥ 10(6). The purified actinium fraction allowed for highly accurate (227)Ac determination at analytical scales, i.e., at (227)Ac activities of 1-100 kBq (27 nCi to 2.7 μCi).

  8. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  9. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Science.gov (United States)

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development.

  10. Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.

    Science.gov (United States)

    Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R; Wai, Chien M

    1999-09-01

    A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

  11. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  12. Relativistic small-core pseudopotentials for actinium, thorium, and protactinium.

    Science.gov (United States)

    Weigand, Anna; Cao, Xiaoyan; Hangele, Tim; Dolg, Michael

    2014-04-03

    Small-core pseudopotentials for actinium, thorium, and protactinium have been energy-adjusted to multiconfiguration Dirac-Hartree-Fock reference data based on the Dirac-Coulomb-Breit Hamiltonian and the Fermi nucleus model. Corresponding optimized valence basis sets of polarized valence quadruple-ζ quality are presented. Atomic test calculations for the first four ionization potentials show satisfactory results at both the Hartree-Fock and the multireference averaged coupled-pair functional level. Highly correlated Fock-space coupled cluster calculations demonstrate that the new pseudopotentials yield ionization potentials, which are in excellent agreement with corresponding all-electron results and experimental data. The pseudopotentials and basis sets supplement a similar set previously published for uranium.

  13. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  14. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Energy Technology Data Exchange (ETDEWEB)

    Raeder, S., E-mail: s.raeder@gsi.de [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Bastin, B. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Block, M. [Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Institut für Kernchemie, Johannes Gutenberg Universität, 55128 Mainz (Germany); Creemers, P. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Ferrer, R. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fléchard, X. [LPC Caen, ENSICAEN, Université de Caen, CNRS/IN2P3, Caen (France); Franchoo, S. [Institute de Physique Nucléaire (IPN) d’Orsay, 91406 Orsay, Cedex (France); Ghys, L. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); SCK-CEN, Belgian Nuclear Research Center, Boeretang 200, 2400 Mol (Belgium); Gaffney, L.P.; Granados, C. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Heinke, R. [Institut für Physik, Johannes Gutenberg Universität, 55128 Mainz (Germany); Hijazi, L. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); and others

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  15. Gclust Server: 225 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 225 HSA_4506945 Cluster Sequences Related Sequences(172) 1827 NP_001032.1 sucrase-isomalt...ed Sequences(172) Sequence length 1827 Representative annotation NP_001032.1 sucrase-isomalt

  16. Ac, La, and Ce radioimpurities in {sup 225}Ac produced in 40-200 MeV proton irradiations of thorium

    Energy Technology Data Exchange (ETDEWEB)

    Engle, Jonathan W.; Ballard, Beau D. [Los Alamos National Laboratory, NM (United States); Weidner, John W. [Air Force Institute of Technology, Wright Patterson Air Force Base, OH (United States); and others

    2014-10-01

    Accelerator production of {sup 225}Ac addresses the global supply deficiency currently inhibiting clinical trials from establishing {sup 225}Ac's therapeutic utility, provided that the accelerator product is of sufficient radionuclidic purity for patient use. Two proton activation experiments utilizing the stacked foil technique between 40 and 200 MeV were employed to study the likely co-formation of radionuclides expected to be especially challenging to separate from {sup 225}Ac. Foils were assayed by nondestructive γ-spectroscopy and by α-spectroscopy of chemically processed target material. Nuclear formation cross sections for the radionuclides {sup 226}Ac and {sup 227}Ac as well as lower lanthanide radioisotopes {sup 139}Ce, {sup 141}Ce, {sup 143}Ce, and {sup 140}La whose elemental ionic radii closely match that of actinium were measured and are reported. The predictions of the latest MCNP6 event generators are compared with measured data, as they permit estimation of the formation rates of other radionuclides whose decay emissions are not clearly discerned in the complex spectra collected from {sup 232}Th(p,x) fission product mixtures. (orig.)

  17. 48 CFR 225.7502 - Procedures.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Balance of Payments Program 225.7502 Procedures. If the Balance of Payments Program applies to the acquisition, follow the procedures at PGI 225.7502....

  18. 48 CFR 225.7001 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Definitions. 225.7001 Section 225.7001 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... term has the meaning given in the clause at 252.225-7019, Restriction on Acquisition of Anchor...

  19. 33 CFR 136.225 - Authorized claimants.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Authorized claimants. 136.225 Section 136.225 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.225...

  20. 25 CFR 225.21 - Negotiation procedures.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Negotiation procedures. 225.21 Section 225.21 Indians... SOLID MINERALS AGREEMENTS Minerals Agreements § 225.21 Negotiation procedures. (a) An Indian mineral... information during the negotiation process. The Secretary shall provide advice, assistance, and information...

  1. 49 CFR 397.225 - Judicial review.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Judicial review. 397.225 Section 397.225... MATERIALS; DRIVING AND PARKING RULES Preemption Procedures § 397.225 Judicial review. A party to a proceeding under § 397.205(a), § 397.213(a), or § 397.223(a) may seek review by the appropriate...

  2. 7 CFR 225.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 225.3 Section 225.3 Agriculture... CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM General § 225.3 Administration. (a) Responsibility within the Department. FNS shall act on behalf of the Department in the administration of the Program....

  3. 21 CFR 225.110 - Distribution records.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Distribution records. 225.110 Section 225.110 Food...: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Records and Reports § 225.110 Distribution records. (a) Distribution records permit the manufacturer to relate complaints to specific batches...

  4. 12 CFR 225.31 - Control proceedings.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Control proceedings. 225.31 Section 225.31... Proceedings § 225.31 Control proceedings. (a) Preliminary determination of control. (1) The Board may issue a... proceeding. (c) Hearing and final determination. (1) The Board shall order a formal hearing or...

  5. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  6. 48 CFR 225.7007-1 - Restrictions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions. 225.7007-1 Section 225.7007-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... subsequent DoD appropriations acts, do not acquire welded shipboard anchor and mooring chain, four inches...

  7. 48 CFR 225.7503 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Balance of Payments Program 225.7503 Contract clauses. Unless the entire acquisition is exempt from the Balance of Payments Program— (a) Use the clause at 252.225-7044, Balance of Payments Program—Construction Material, in solicitations and...

  8. 42 CFR 93.225 - Respondent.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Respondent. 93.225 Section 93.225 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  9. 40 CFR 86.225-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false 86.225-94 Section 86.225-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty...

  10. 31 CFR 800.225 - United States.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States. 800.225 Section 800... TAKEOVERS BY FOREIGN PERSONS Definitions § 800.225 United States. The term United States or U.S. means the United States of America, the States of the United States, the District of Columbia, and any...

  11. 22 CFR 225.114 - Cooperative research.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Cooperative research. 225.114 Section 225.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible...

  12. 21 CFR 225.158 - Laboratory assays.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory assays. 225.158 Section 225.158 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... Laboratory assays. Where the results of laboratory assays of drug components, including assays by State...

  13. 21 CFR 225.58 - Laboratory controls.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory controls. 225.58 Section 225.58 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... Laboratory controls. (a) The periodic assay of medicated feeds for drug components provides a measure...

  14. 48 CFR 225.104 - Nonavailable articles.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Nonavailable articles. 225.104 Section 225.104 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Nonavailable articles. (a) DoD has determined that the following articles also are nonavailable in...

  15. 44 CFR 206.225 - Emergency work.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Emergency work. 206.225 Section 206.225 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... that a threat exists, including identification and evaluation of the threat and recommendations of...

  16. 20 CFR 225.30 - General.

    Science.gov (United States)

    2010-04-01

    ... DETERMINATIONS Delayed Retirement Credits § 225.30 General. (a) A delayed retirement credit (DRC) is a percentage... Social Security Act based on combined railroad and social security earnings can earn DRC's. A DRC can...

  17. Cyclotron and linac production of Ac-225.

    Science.gov (United States)

    Melville, Graeme; Allen, Barry J

    2009-04-01

    Radium needles that were once implanted into tumours as a cancer treatment are now obsolete and constitute a radioactive waste problem, as their half-life is 1600 years. The reduction of radium by photonuclear transmutation by bombarding Ra-226 with high-energy photons from a medical linear accelerator (linac) has been investigated. A linac dose of 2800 Gy produced about 2.4 MBq (64 microCi) of Ra-225, which decays to Ac-225 and can then be used for 'Targeted Alpha Therapy' (TAT) of cancer. This result, while consistent with theoretical calculations, is far too low to be of practical use unless much larger quantities of radium are irradiated. The increasing application of Ac-225 for cancer therapy indicates the potential need for its increased production and availability. This paper investigates the possibility of producing of Ac-225 in commercial quantities, which could potentially reduce obsolete radioactive material and displace the need for expensive importation of Ac-225 from the USA and Russia in the years ahead. Scaled up production of Ac-225 could theoretically be achieved by the use of a high current cyclotron or linac. Production specifications are determined for a linac in terms of current, pulse length and frequency, as well as an examination of other factors such as radiation issues and radionuclei separation. Yields are compared with those calculated for the Australian National Cyclotron in Sydney.

  18. Dicty_cDB: CHR225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR225 (Link to dictyBase) - - - Contig-U11316-1 - (Link to Original site) - - CHR...225Z 621 - - - - Show CHR225 Library CH (Link to library) Clone ID CHR225 (Link to dicty...iol.tsukuba.ac.jp/CSM/CH/CHR2-B/CHR225Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >CHR225 (CHR225Q) /CSM/CH/CHR2-B/CHR225Q.Seq.d/ XXXXXXXXXXTTAGCTC... CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CHR225 (CHR225Q) /CSM/CH/CHR2-B/CHR

  19. 48 CFR 225.7003-3 - Exceptions.

    Science.gov (United States)

    2010-10-01

    ... requests to the Under Secretary of Defense (Acquisition, Technology, and Logistics) (USD(AT&L)) for a... incorporated into COTS end items, subsystems, or assemblies; or (2) The fasteners qualify for the commercial... the procedures at PGI 225.7003-3(b)(2). (3) Fasteners that are commercial items and are acquired...

  20. 48 CFR 225.7501 - Policy.

    Science.gov (United States)

    2010-10-01

    ... DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Balance of Payments Program 225.7501 Policy. Acquire... comparative cost of application of the Balance of Payments Program to the total acquisition; or (v) Use of a... the Balance of Payments Program evaluation factor would not result in award on a domestic offer; or...

  1. 29 CFR 779.225 - Leased departments.

    Science.gov (United States)

    2010-07-01

    ..., Franchise and Other Business Arrangements § 779.225 Leased departments. (a) As stated in section 3(r) of the... activities of the establishment in which they are located, and they are performed for a common business... records, and in other respects conducts his business independently of the lessor's, the lessee may...

  2. From Beamline to Scanner with 225Ac

    Science.gov (United States)

    Robertson, Andrew K. H.; Ramogida, Caterina F.; Kunz, Peter; Rodriguez-Rodriguez, Cristina; Schaffer, Paul; Sossi, Vesna

    2016-09-01

    Due to the high linear energy transfer and short range of alpha-radiation, targeted radiation therapy using alpha-emitting pharmaceuticals that successfully target small disease clusters will kill target cells with limited harm to healthy tissue, potentially treating the most aggressive forms of cancer. As the parent of a decay chain with four alpha- and two beta-decays, 225Ac is a promising candidate for such a treatment. However, this requires retention of the entire decay chain at the target site, preventing the creation of freely circulating alpha-emitters that reduce therapeutic effect and increase toxicity to non-target tissues. Two major challenges to 225Ac pharmaceutical development exist: insufficient global supply, and the difficulty of preventing toxicity by retaining the entire decay chain at the target site. While TRIUMF works towards large-scale (C i amounts) production of 225Ac, we already use our Isotope Separation On-Line facility to provide small (overview of this research program and the journey of 225Ac from the beamline to the scanner. This research is funded by the Natural Sciences and Engineering Research Council of Canada.

  3. 48 CFR 225.872-6 - Audit.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Audit. 225.872-6 Section...-6 Audit. (a) Memoranda of understanding with some qualifying countries contain annexes that provide for reciprocal “no-cost” audits of contracts and subcontracts (pre- and post-award). (b) To...

  4. 48 CFR 225.7002-1 - Restrictions.

    Science.gov (United States)

    2010-10-01

    ... guidance and examples, see PGI 225.7002-1(a)(2). (3) Tents, tarpaulins, or covers. (4) Cotton and other...) Synthetic fabric or coated synthetic fabric, including all textile fibers and yarns that are for use in such fabrics. (8) Canvas products. (9) Wool (whether in the form of fiber or yarn or contained in...

  5. 48 CFR 225.7303-4 - Contingent fees.

    Science.gov (United States)

    2010-10-01

    ...-4 Section 225.7303-4 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Acquisitions for Foreign Military Sales 225... governments of Australia, Taiwan, Egypt, Greece, Israel, Japan, Jordan, Republic of Korea, Kuwait,...

  6. 25 CFR 225.26 - Auditing and accounting.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Auditing and accounting. 225.26 Section 225.26 Indians... SOLID MINERALS AGREEMENTS Minerals Agreements § 225.26 Auditing and accounting. The Secretary may... agreement. Procedures and standards used for accounting and auditing of minerals agreements will be...

  7. 48 CFR 225.7007-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause. 225.7007-3 Section 225.7007-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... granted, use the clause at 252.225-7019, Restriction on Acquisition of Anchor and Mooring Chain,...

  8. 20 CFR 225.21 - Survivor Tier I PIA.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Survivor Tier I PIA. 225.21 Section 225.21... INSURANCE AMOUNT DETERMINATIONS PIA's Used in Computing Survivor Annuities and the Amount of the Residual Lump-Sum Payable § 225.21 Survivor Tier I PIA. The Survivor Tier I PIA is used in computing the tier...

  9. 33 CFR 183.225 - Flotation test for persons capacity.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Flotation test for persons capacity. 183.225 Section 183.225 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Boats Rated for Engines of More Than 2 Horsepower Tests § 183.225 Flotation test for persons...

  10. 12 CFR 225.129 - Activities closely related to banking.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.129 Section 225.129 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.129 Activities closely related to banking. Courier activities....

  11. 12 CFR 225.123 - Activities closely related to banking.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.123 Section 225.123 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.123 Activities closely related to banking. (a) Effective June...

  12. 24 CFR 884.225 - PHA reporting requirements. [Reserved

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false PHA reporting requirements. 884.225 Section 884.225 Housing and Urban Development Regulations Relating to Housing and Urban Development... RURAL RENTAL HOUSING PROJECTS Project Development and Operation § 884.225 PHA reporting requirements....

  13. 40 CFR 225.3 - Procedure for invoking economic impact.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Procedure for invoking economic impact. 225.3 Section 225.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING CORPS OF ENGINEERS DREDGED MATERIAL PERMITS § 225.3 Procedure for invoking economic impact....

  14. 33 CFR 117.225 - Yellow Mill Channel.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Yellow Mill Channel. 117.225 Section 117.225 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.225 Yellow Mill Channel....

  15. A study of 225 000 $\\tau^{+}$ decays

    CERN Document Server

    Devaux, B; Diamant-Berger, Alain M; Extermann, P; Fischer, J; Maillard, J; Marel, Gérard; Mermos, R; Rosselet, L; Sachot, R; Turlay, René

    1977-01-01

    Results of the analysis of 225 000 tau /sup +/ decays in flight recorded at the CERN-PS with an electronic detector are presented. A quadratic fit of the matrix element mod M mod /sup 2/ varies as 1+aY+b X/sup 2/+cY/sup 2/ gives the following values for the parameters: a =0.2814+or-0.0082; b=-0.099+or-0.019; c=-0.001+or-0.023. (15 refs).

  16. 12 CFR 225.44 - Reporting of stock loans.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Reporting of stock loans. 225.44 Section 225.44... § 225.44 Reporting of stock loans. (a) Requirements. (1) Any foreign bank or affiliate of a foreign bank... involves a person or group of persons that has been the owner or owners of record of the stock for a...

  17. 48 CFR 225.7500 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Balance of Payments Program 225.7500 Scope of subpart. This subpart provides policies and procedures implementing the Balance of Payments Program....

  18. 49 CFR 225.33 - Internal Control Plans.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Internal Control Plans. 225.33 Section 225.33....33 Internal Control Plans. (a) Each railroad shall adopt and comply with a written Internal Control... official business. Each railroad shall amend its Internal Control Plan, as necessary, to reflect...

  19. 21 CFR 225.1 - Current good manufacturing practice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Current good manufacturing practice. 225.1 Section...) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS General Provisions § 225.1 Current good manufacturing practice. (a) Section 501(a)(2)(B) of the Federal Food, Drug, and Cosmetic...

  20. 7 CFR 1280.225 - Books and records of persons.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Books and records of persons. 1280.225 Section 1280... PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Reports, Books, and Records § 1280.225 Books and records of persons. (a) Each first handler, exporter of lambs,...

  1. 7 CFR 225.4 - Program management and administration plan.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Program management and administration plan. 225.4... Provisions § 225.4 Program management and administration plan. (a) Not later than February 15 of each year, each State agency shall submit to FNSRO a Program management and administration plan for that...

  2. 48 CFR 1852.225-70 - Export Licenses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Export Licenses. 1852.225... 1852.225-70 Export Licenses. As prescribed in 1825.1103-70(b), insert the following clause: Export Licenses (FEB 2000) (a) The Contractor shall comply with all U.S. export control laws and...

  3. 7 CFR 225.14 - Requirements for sponsor participation.

    Science.gov (United States)

    2010-01-01

    ... 225.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM Sponsor and Site Provisions... Youth Sports Program; and (5) Private nonprofit organizations as defined in § 225.2. (c)...

  4. 48 CFR 252.225-7041 - Correspondence in English.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Correspondence in English... of Provisions And Clauses 252.225-7041 Correspondence in English. As prescribed in 225.1103(2), use the following clause: Correspondence in English (JUN 1997) The Contractor shall ensure that...

  5. 14 CFR 121.225 - Propeller deicing fluid.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Propeller deicing fluid. 121.225 Section 121.225 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Propeller deicing fluid. If combustible fluid is used for propeller deicing, the certificate holder...

  6. 12 CFR 225.132 - Acquisition of assets.

    Science.gov (United States)

    2010-01-01

    ... Companies Interpretations § 225.132 Acquisition of assets. (a) From time to time questions have arisen as to... the Board's Regulation Y (12 CFR 225.4(c)(3)) generally prohibits a bank holding company or its... any merger “or acquisition of assets other than in the ordinary course of business” without...

  7. 5 CFR 591.225 - Which CPIs does OPM use?

    Science.gov (United States)

    2010-01-01

    ... Allowances § 591.225 Which CPIs does OPM use? OPM uses the following CPIs: (a) For the Washington, DC, area—the BLS Consumer Price Index, All Urban Consumers (CPI-U); (b) For all COLA areas in the State of... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Which CPIs does OPM use? 591.225...

  8. 48 CFR 225.870-8 - Industrial security.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial security. 225... Coordination 225.870-8 Industrial security. Industrial security for Canada shall be in accordance with the U.S.-Canada Industrial Security Agreement of March 31, 1952, as amended....

  9. 7 CFR 225.8 - Records and reports.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Records and reports. 225.8 Section 225.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... whether the site is rural or urban, or vended or self-preparation....

  10. Towards an EDM Measurement in Radium-225

    Science.gov (United States)

    Dietrich, Matthew; Bailey, K.; Greene, J.; Holt, R.; Kalita, M.; Korsch, W.; Lu, Z.-T.; Mueller, P.; O'Connor, T.; Parker, R.; Singh, J.

    2012-06-01

    The existence of an atomic electric dipole moment (EDM) would violate both the time and parity symmetries of nature, and so the measurement of one would give a valuable window into physics beyond the standard model. Here we describe recent progress towards measurement of the EDM of radium-225, which is expected to be abnormally large compared to other species. Neutral cold radium atoms are loaded from a magneto-optic trap into an optical dipole trap (ODT), which is mechanically translated to move the radium into the science region. We then transfer the atoms to a second, standing wave ODT suitable for the EDM measurement. In the near future, we plan to optically pump and observe nuclear spin precession. This research is supported by DOE, Office of Nuclear Physics contract No. DE-AC02-06CH11357.

  11. Cyclotron production of Ac-225 for targeted alpha therapy.

    Science.gov (United States)

    Apostolidis, C; Molinet, R; McGinley, J; Abbas, K; Möllenbeck, J; Morgenstern, A

    2005-03-01

    The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.

  12. 48 CFR 225.872-3 - Solicitation procedures.

    Science.gov (United States)

    2010-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Other International Agreements... Corporation in accordance with 225.870. (c) Use international air mail if solicitation destinations are... (Acquisition, Technology, and Logistics), before excluding the qualifying country source from consideration....

  13. 48 CFR 252.225-7037 - Evaluation of Offers for Air Circuit Breakers.

    Science.gov (United States)

    2010-10-01

    ... Air Circuit Breakers. 252.225-7037 Section 252.225-7037 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.225-7037 Evaluation of Offers for Air Circuit Breakers. As prescribed in 225.7006-4(a), use the following provision: Evaluation of Offers for Air Circuit Breakers...

  14. Design and synthesis of {sup 225}Ac radioimmunopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    McDevitt, Michael R.; Ma, Dangshe; Simon, Jim; Frank, R. Keith; Scheinberg, David A. E-mail: d-scheinberg@ski.mskcc.org

    2002-12-01

    The alpha-particle-emitting radionuclides {sup 213}Bi, {sup 211}At, {sup 224}Ra are under investigation for the treatment of leukemias, gliomas, and ankylosing spondylitis, respectively. {sup 213}Bi and {sup 211}At were attached to monoclonal antibodies and used as targeted immunotherapeutic agents while unconjugated {sup 224}Ra chloride selectively seeks bone. {sup 225}Ac possesses favorable physical properties for radioimmunotherapy (10 d half-life and 4 net alpha particles), but has a history of unfavorable radiolabeling chemistry and poor metal-chelate stability. We selected functionalized derivatives of DOTA as the most promising to pursue from out of a group of potential {sup 225}Ac chelate compounds. A two-step synthetic process employing either MeO-DOTA-NCS or 2B-DOTA-NCS as the chelating moiety was developed to attach {sup 225}Ac to monoclonal antibodies. This method was tested using several different IgG systems. The chelation reaction yield in the first step was 93{+-}8% radiochemically pure (n=26). The second step yielded {sup 225}Ac-DOTA-IgG constructs that were 95{+-}5% radiochemically pure (n=27) and the mean percent immunoreactivity ranged from 25% to 81%, depending on the antibody used. This process has yielded several potential novel targeted {sup 225}Ac-labeled immunotherapeutic agents that may now be evaluated in appropriate model systems and ultimately in humans.

  15. 48 CFR 752.225-71 - Local procurement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Local procurement. 752.225... Local procurement. For use in any USAID contract involving performance overseas. Local Procurement (FEB 1997) (a) Local procurement involves the use of appropriated funds to finance the procurement of...

  16. 40 CFR 1065.225 - Intake-air flow meter.

    Science.gov (United States)

    2010-07-01

    ... CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments Flow-Related Measurements § 1065.225 Intake-air... § 1065.205. This may include a laminar flow element, an ultrasonic flow meter, a subsonic venturi, a... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Intake-air flow meter....

  17. 27 CFR 28.225 - Removals of beer by brewer.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removals of beer by brewer..., DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Beer With Benefit of Drawback Execution of Claims § 28.225 Removals of beer by brewer. Where a brewer removes taxpaid beer from...

  18. Improved limit on the $^{225}$Ra electric dipole moment

    CERN Document Server

    Bishof, Michael; Bailey, Kevin G; Greene, John P; Holt, Roy J; Kalita, Mukut R; Korsch, Wolfgang; Lemke, Nathan D; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P; Singh, Jaideep T; Dietrich, Matthew R

    2016-01-01

    Background: Octupole-deformed nuclei, such as that of $^{225}$Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015, we reported the first "proof-of-principle" measurement of the $^{225}$Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our $^{225}$Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Method: Laser-cooled and trapped $^{225}$Ra atoms are held between two high voltage electrodes in an ultra high vacuum chamber at the center of a magnetically shielded environment. We observe Larmor precession in a uniform magnetic field using nuclear-spin-dependent laser light scattering and look for a phase shift proportional to the applied electric field, which indicates the existence of an EDM. The main improvement to o...

  19. 24 CFR 964.225 - Resident management requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Resident management requirements... Program § 964.225 Resident management requirements. The following requirements apply when a HA and its... contracting with a HA must establish a resident management corporation that meets the requirements for such...

  20. Improved experimental limit on the EDM of 225Ra

    Science.gov (United States)

    Bishof, Michael; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Tom P.; Parker, Richard H.; Rabga, Tenzin; Singh, Jaideep T.

    2015-10-01

    Searches for permanent electric dipole moments (EDMs) in fundamental and composite particles are sensitive probes of beyond-standard-model symmetry violation that could explain the dominance of matter over anti-matter. The 225Ra (t1/2 = 15d, I = 1/2) atom is a particularly attractive system to use for an EDM measurement because its large nuclear octupole deformation, closely spaced ground-state parity doublet, and large atomic mass make 225Ra uniquely sensitive to symmetry-violating interactions in the nuclear medium. We have developed an experiment to measure the EDM of 225Ra and demonstrated the first ``proof-of-principle'' measurement, giving a 95% confidence upper limit of 5E-22 e-cm. After implementing a vacuum upgrade, we have observed nuclear spin coherence after 20 s of free evolution - a factor of ten improvement over our earlier results - and have lowered the 225Ra EDM limit by over an order of magnitude. Upcoming experimental upgrades have the potential to further improve our EDM sensitivity by many orders of magnitude, allowing us to test symmetry violation at an unprecedented level. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  1. 48 CFR 225.7005 - Restriction on certain chemical weapons antidote.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on certain chemical weapons antidote. 225.7005 Section 225.7005 Federal Acquisition Regulations System DEFENSE... on certain chemical weapons antidote....

  2. Improved limit on the 225Ra electric dipole moment

    Science.gov (United States)

    Bishof, Michael; Parker, Richard H.; Bailey, Kevin G.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Singh, Jaideep T.; Dietrich, Matthew R.

    2016-08-01

    Background: Octupole-deformed nuclei, such as that of 225Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015 we reported the first "proof-of-principle" measurement of the 225Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our 225Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Method: Laser-cooled and trapped 225Ra atoms are held between two high-voltage electrodes in an ultrahigh-vacuum chamber at the center of a magnetically-shielded environment. We observe Larmor precession in a uniform magnetic field using nuclear-spin-dependent laser light scattering and look for a phase shift proportional to the applied electric field, which indicates the existence of an EDM. The main improvement to our measurement technique is an order-of-magnitude increase in spin-precession time, which is enabled by an improved vacuum system and a reduction in trap-induced heating. Results: We have measured the 225Ra atomic EDM to be less than 1.4 ×10-23e cm (95 % confidence upper limit), which is a factor of 36 improvement over our previous result. Conclusions: Our evaluation of systematic effects shows that this measurement is completely limited by statistical uncertainty. Combining this measurement technique with planned experimental upgrades, we project a statistical sensitivity at the 1 ×10-28e cm level and a total systematic uncertainty at the 4 ×10-29e cm level.

  3. 12 CFR 225.174 - What aggregate thresholds apply to merchant banking investments?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What aggregate thresholds apply to merchant banking investments? 225.174 Section 225.174 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF...) Regulations Merchant Banking Investments § 225.174 What aggregate thresholds apply to merchant...

  4. 12 CFR 225.126 - Activities not closely related to banking.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities not closely related to banking. 225.126 Section 225.126 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE... Financial Holding Companies Interpretations § 225.126 Activities not closely related to banking. Pursuant...

  5. 12 CFR 225.172 - What are the holding periods permitted for merchant banking investments?

    Science.gov (United States)

    2010-01-01

    ... applicable under the Board's capital adequacy rules or guidelines (see 12 CFR 225 appendix A) to merchant... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What are the holding periods permitted for merchant banking investments? 225.172 Section 225.172 Banks and Banking FEDERAL RESERVE SYSTEM...

  6. 48 CFR 252.225-7001 - Buy American Act and Balance of Payments Program.

    Science.gov (United States)

    2010-10-01

    ... Balance of Payments Program. 252.225-7001 Section 252.225-7001 Federal Acquisition Regulations System... Payments Program. As prescribed in 225.1101(2), use the following clause: Buy American Act and Balance of... products in the Buy American Act—Balance of Payments Program Certificate provision of the solicitation....

  7. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation...

  8. 48 CFR 252.225-7030 - Restriction on Acquisition of Carbon, Alloy, and Armor Steel Plate.

    Science.gov (United States)

    2010-10-01

    ... of Carbon, Alloy, and Armor Steel Plate. 252.225-7030 Section 252.225-7030 Federal Acquisition... Acquisition of Carbon, Alloy, and Armor Steel Plate. As prescribed in 225.7011-3, use the following clause: Restriction on Acquisition of Carbon, Alloy, and Armor Steel Plate (DEC 2006) (a) Carbon, alloy, and...

  9. 25 CFR 225.4 - Authority and responsibility of the Bureau of Land Management (BLM).

    Science.gov (United States)

    2010-04-01

    ... Agreements: Unproven Areas, 43 CFR part 3260—Geothermal Resources Operations, 43 CFR part 3280—Geothermal... Management (BLM). 225.4 Section 225.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS AGREEMENTS General § 225.4 Authority...

  10. Nuclear Structure Effects in the Exotic Decay of $^{225}$Ac via $^{14}$C Emission

    CERN Multimedia

    2002-01-01

    % IS323 \\\\ \\\\ We propose to build at Isolde a high intensity $^{225}$Ac source by $\\beta$-decay of $^{225}$(Ra+Fr) beam, to be used at the superconducting spectrometer SOLENO of IPN-Orsay in order to study a possible fine structure in the spectrum of $^{14}$C ions spontaneously emitted by $^{225}$Ac.

  11. 48 CFR 52.225-14 - Inconsistency between English Version and Translation of Contract.

    Science.gov (United States)

    2010-10-01

    ... English Version and Translation of Contract. 52.225-14 Section 52.225-14 Federal Acquisition Regulations... CLAUSES Text of Provisions and Clauses 52.225-14 Inconsistency between English Version and Translation of... and Translation of Contract (FEB 2000) In the event of inconsistency between any terms of...

  12. 20 CFR 225.32 - DRC's and the Special Minimum PIA.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false DRC's and the Special Minimum PIA. 225.32 Section 225.32 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS Delayed Retirement Credits § 225.32 DRC's and the Special...

  13. 27 CFR 25.225 - Destruction of taxpaid beer which was never removed from brewery premises.

    Science.gov (United States)

    2010-04-01

    ... beer which was never removed from brewery premises. 25.225 Section 25.225 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Voluntary Destruction § 25.225 Destruction of taxpaid beer which was never removed from brewery premises. (a) General....

  14. 48 CFR 252.225-7038 - Restriction on Acquisition of Air Circuit Breakers.

    Science.gov (United States)

    2010-10-01

    ... of Air Circuit Breakers. 252.225-7038 Section 252.225-7038 Federal Acquisition Regulations System... Circuit Breakers. As prescribed in 225.7006-4(b), use the following clause: Restriction on Acquisition of Air Circuit Breakers (JUN 2005) Unless otherwise specified in its offer, the Contractor shall...

  15. 48 CFR 225.7703 - Acquisition of products or services other than small arms.

    Science.gov (United States)

    2010-10-01

    ... in Support of Operations in Iraq or Afghanistan 225.7703 Acquisition of products or services other... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of products or services other than small arms. 225.7703 Section 225.7703 Federal Acquisition Regulations System...

  16. 48 CFR 252.225-7026 - Acquisition Restricted to Products or Services from Iraq or Afghanistan.

    Science.gov (United States)

    2010-10-01

    ... Products or Services from Iraq or Afghanistan. 252.225-7026 Section 252.225-7026 Federal Acquisition... to Products or Services from Iraq or Afghanistan. As prescribed in 225.7703-5(c), use the following clause: Acquisition Restricted to Products or Services From Iraq or Afghanistan (APR 2010)...

  17. 22 CFR 225.118 - Applications and proposals lacking definite plans for involvement of human subjects.

    Science.gov (United States)

    2010-04-01

    ... plans for involvement of human subjects. 225.118 Section 225.118 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.118 Applications and proposals lacking definite plans for involvement of human subjects. Certain types of applications for grants,...

  18. 48 CFR 225.871 - North Atlantic Treaty Organization (NATO) cooperative projects.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false North Atlantic Treaty Organization (NATO) cooperative projects. 225.871 Section 225.871 Federal Acquisition Regulations System... Other International Agreements and Coordination 225.871 North Atlantic Treaty Organization...

  19. Production of AC-225 and application of the BI-213 daughter in cancer therapy

    Science.gov (United States)

    Koch, L.; Apostolidis, C.; Janssens, W.; Molinet, R.; van Geel, J.

    1999-01-01

    There are several ongoing medical trials to use Bi-213 conjugated to monoclonal antibodies to kill tumour-cells of various cancer types. The institute is supplying Ac-225 generators for the test and is itself engaged in in-vitro cytotoxicity tests. Nuclear reactions leading to Ac-225 are discussed. The present supply of Ac-225 stems from Th-229 decay obtained from aged U-233. From the possible alternative the reactions Ra-226 (p, 2n) Ac-225 is presently favoured. The fabrication of a Ac-225 for Bi-213 generator will be described.

  20. First Measurement of the Atomic Electric Dipole Moment of (225)Ra.

    Science.gov (United States)

    Parker, R H; Dietrich, M R; Kalita, M R; Lemke, N D; Bailey, K G; Bishof, M; Greene, J P; Holt, R J; Korsch, W; Lu, Z-T; Mueller, P; O'Connor, T P; Singh, J T

    2015-06-12

    The radioactive radium-225 ((225)Ra) atom is a favorable case to search for a permanent electric dipole moment. Because of its strong nuclear octupole deformation and large atomic mass, (225)Ra is particularly sensitive to interactions in the nuclear medium that violate both time-reversal symmetry and parity. We have developed a cold-atom technique to study the spin precession of (225)Ra atoms held in an optical dipole trap, and demonstrated the principle of this method by completing the first measurement of its atomic electric dipole moment, reaching an upper limit of |d((225)Ra)|<5.0×10(-22)  e cm (95% confidence).

  1. First Measurement of the Atomic Electric Dipole Moment of $^{225}$Ra

    CERN Document Server

    Parker, R H; Kalita, M R; Lemke, N D; Bailey, K G; Bishof, M N; Greene, J P; Holt, R J; Korsch, W; Lu, Z -T; Mueller, P; O'Connor, T P; Singh, J T

    2015-01-01

    The radioactive radium-225 ($^{225}$Ra) atom is a favorable case to search for a permanent electric dipole moment (EDM). Due to its strong nuclear octupole deformation and large atomic mass, $^{225}$Ra is particularly sensitive to interactions in the nuclear medium that violate both time-reversal symmetry and parity. We have developed a cold-atom technique to study the spin precession of $^{225}$Ra atoms held in an optical dipole trap, and demonstrated the principle of this method by completing the first measurement of its atomic EDM, reaching an upper limit of $|$$d$($^{225}$Ra)$|$ $<$ $5.0\\!\\times\\!10^{-22}$ $e \\cdot$cm (95$\\%$ confidence).

  2. 225 GHz Atmospheric Opacity Measurements from Two Arctic Sites

    CERN Document Server

    Matsushita, S; Martin-Cocher, P; Asada, K; Chen, C -P; Inoue, M; Paine, S; Turner, D; Steinbring, E

    2012-01-01

    We report the latest results of 225 GHz atmospheric opacity measurements from two arctic sites; one on high coastal terrain near the Eureka weather station, on Ellesmere Island, Canada, and the other at the Summit Station near the peak of the Greenland icecap. This is a campaign to search for a site to deploy a new telescope for submillimeter Very Long Baseline Interferometry and THz astronomy in the northern hemisphere. Since 2011, we have obtained 3 months of winter data near Eureka, and about one year of data at the Summit Station. The results indicate that these sites offer a highly transparent atmosphere for observations in submillimeter wavelengths. The Summit Station is particularly excellent, and its zenith opacity at 225 GHz is statistically similar to the Atacama Large Milllimeter/submillimeter Array in Chile. In winter, the opacity at the Summit Station is even comparable to that observed at the South Pole.

  3. An improved limit on the EDM of 225 Ra

    Science.gov (United States)

    Bishof, Michael; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Parker, Richard H.; Rabga, Tenzin; Singh, Jaideep T.

    2016-05-01

    Searches for permanent electric dipole moments (EDMs) are sensitive probes of symmetry violation that could explain the dominance of matter over anti-matter. The 225 Ra (t1/2 = 15 days, I = 1/2) atom is a particularly attractive system to use for an EDM measurement because its octupole-deformed nucleus, closely spaced ground-state parity doublet, and large nuclear charge make 225 Ra uniquely sensitive to symmetry-violating interactions in the nuclear medium. In 2015, we reported the first ``proof of principle'' measurement of the 225 Ra EDM, giving a 95% confidence upper limit of 5* 10-22 e-cm; representing the first EDM measurement using laser-trapped atoms as well as the first EDM measurement of an atom with an octupole-deformed nucleus. After implementing upgrades to our apparatus, we now observe nuclear spin coherence after 20 s of free evolution - a factor of ten improvement. A new EDM measurement based on the upgraded system improved the 95% confidence upper limit by a factor of 36. We also report on the progress of current experimental upgrades that have the potential to further improve our EDM sensitivity by many orders of magnitude, allowing us to test symmetry violation at an unprecedented level. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  4. 48 CFR 225.7015 - Restriction on overseas architect-engineer services.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on overseas architect-engineer services. 225.7015 Section 225.7015 Federal Acquisition Regulations System DEFENSE... on overseas architect-engineer services. For restriction on award of architect-engineer contracts...

  5. 48 CFR 225.7007 - Restrictions on anchor and mooring chain.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions on anchor and mooring chain. 225.7007 Section 225.7007 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Authorization...

  6. 48 CFR 252.225-7019 - Restriction on acquisition of anchor and mooring chain.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on acquisition of anchor and mooring chain. 252.225-7019 Section 252.225-7019 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION...

  7. 48 CFR 252.225-7033 - Waiver of United Kingdom levies.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom... of Provisions And Clauses 252.225-7033 Waiver of United Kingdom levies. As prescribed in 225.1101(9), use the following clause: Waiver of United Kingdom Levies (APR 2003) (a) The U.S. Government...

  8. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a), use the following clause: Balance of Payments...

  9. 48 CFR 225.7011 - Restriction on carbon, alloy, and armor steel plate.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on carbon, alloy, and armor steel plate. 225.7011 Section 225.7011 Federal Acquisition Regulations System DEFENSE... on carbon, alloy, and armor steel plate....

  10. 12 CFR 225.102 - Bank holding company indirectly owning nonbanking company through subsidiaries.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company indirectly owning nonbanking company through subsidiaries. 225.102 Section 225.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  11. 7 CFR Appendix A to Part 225 - Alternate Foods for Meals

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Alternate Foods for Meals A Appendix A to Part 225 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM Pt. 225, App. A Appendix A to Part...

  12. 7 CFR Appendix C to Part 225 - Child Nutrition (CN) Labeling Program

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Child Nutrition (CN) Labeling Program C Appendix C to... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM Pt. 225, App. C Appendix C to Part 225—Child Nutrition (CN) Labeling Program 1. The Child Nutrition (CN) Labeling...

  13. E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion

    Science.gov (United States)

    Jeong, Eun Il; Chung, Hae Won; Lee, Won Jea; Kim, Seo-Hyun; Kim, Hyunjoo; Choi, Seon-Guk; Jung, Yong-Keun

    2016-01-01

    Cerebral ischemia/reperfusion (I/R) causes brain damage accompanied by ubiquitin accumulation and impairment of proteasome activity. In this study, we report that E2-25K, an E2-conjugating enzyme, is SUMOylated during oxidative stress and regulates cerebral I/R-induced damage. Knockdown of E2-25K expression protects against oxygen/glucose deprivation and reoxygenation (OGD/R)-induced neuronal cell death, whereas ectopic expression of E2-25K stimulates it. Compared with the control mice, cerebral infarction lesions and behavioral/neurological disorders are ameliorated in E2-25K knockout mice during middle cerebral artery occlusion and reperfusion. In particular, E2-25K is SUMOylated at Lys14 under oxidative stress, OGD/R and I/R to prompt cell death. Further, E2-25K downregulates the proteasome subunit S5a to impair proteasome complex and thus restrain proteasome activity under oxidative stress. This proteasome inhibitory activity of E2-25K is dependent on its SUMOylation. These results suggest that E2-25K has a crucial role in oxidative stress and cerebral I/R-induced damage through inhibiting proteasome via its SUMOylation. PMID:28032866

  14. 20 CFR 225.33 - Months for which DRC's are due.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Months for which DRC's are due. 225.33... PRIMARY INSURANCE AMOUNT DETERMINATIONS Delayed Retirement Credits § 225.33 Months for which DRC's are due. (a) A DRC is due for each month after 1970 in which the employee is— (1) Full retirement age or...

  15. 20 CFR 225.36 - Effect of DRC's on survivor annuities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Effect of DRC's on survivor annuities. 225.36... PRIMARY INSURANCE AMOUNT DETERMINATIONS Delayed Retirement Credits § 225.36 Effect of DRC's on survivor... surviving divorced spouse annuity. All DRC's, including credits earned in the year of death, can be used...

  16. 20 CFR 225.34 - How the amount of the DRC is figured.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How the amount of the DRC is figured. 225.34... PRIMARY INSURANCE AMOUNT DETERMINATIONS Delayed Retirement Credits § 225.34 How the amount of the DRC is figured. (a) The amount of the DRC depends on— (1) The year the employee reaches full retirement age;...

  17. 20 CFR 225.31 - PIA's to which DRC's are added.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false PIA's to which DRC's are added. 225.31... PRIMARY INSURANCE AMOUNT DETERMINATIONS Delayed Retirement Credits § 225.31 PIA's to which DRC's are added. (a) DRC's can be added to the following PIA's when used in computing the following benefits: (1)...

  18. 48 CFR 225.7006 - Restriction on air circuit breakers for naval vessels.

    Science.gov (United States)

    2010-10-01

    ... on air circuit breakers for naval vessels. ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on air circuit breakers for naval vessels. 225.7006 Section 225.7006 Federal Acquisition Regulations System...

  19. 7 CFR 1430.225 - Violations of highly erodible land and wetland conservation provisions.

    Science.gov (United States)

    2010-01-01

    ... wetland conservation provisions. The provisions of part 12 of this title apply to this part. ... 7 Agriculture 10 2010-01-01 2010-01-01 false Violations of highly erodible land and wetland conservation provisions. 1430.225 Section 1430.225 Agriculture Regulations of the Department of...

  20. 40 CFR 22.5 - Filing, service, and form of all filed documents; business confidentiality claims.

    Science.gov (United States)

    2010-07-01

    ... documents; business confidentiality claims. 22.5 Section 22.5 Protection of Environment ENVIRONMENTAL... of all filed documents; business confidentiality claims. (a) Filing of documents. (1) The original... knowledge, information and belief, the statements made therein are true, and that it is not interposed...

  1. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false World Trade Organization Government Procurement Agreement and Free Trade Agreements. 225.403 Section 225.403 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Trade...

  2. 48 CFR 252.225-7023 - Preference for products or services from Iraq or Afghanistan.

    Science.gov (United States)

    2010-10-01

    ... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7023 Preference for products or services... Products or Services from Iraq or Afghanistan (APR 2010) (a) Definitions. Product from Iraq or Afghanistan... solicitation entitled “Requirement for Products or Services from Iraq or Afghanistan” (DFARS 252.225-7024)....

  3. 47 CFR 25.225 - Geographic Service Requirements for 17/24 GHz Broadcasting Satellite Service.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Geographic Service Requirements for 17/24 GHz Broadcasting Satellite Service. 25.225 Section 25.225 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Requirements for 17/24 GHz Broadcasting Satellite Service. (a) Each operator of a 17/24 GHz BSS space...

  4. 18 CFR 2.25 - Ratemaking treatment of the cost of emissions allowances in coordination transactions.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Ratemaking treatment of the cost of emissions allowances in coordination transactions. 2.25 Section 2.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES...

  5. FORECASTING NIKKEI 225 INDEX WITH SUPPORT VECTOR MACHINE

    Institute of Scientific and Technical Information of China (English)

    HUANG Wei; Yoshiteru Nakamori; WANG Shouyang; YU Lean

    2003-01-01

    Support Vector Machine (SVM) is a very specific type of learning algorithms characterized by the capacity control of the decision function, the use of the kernel functions and the sparsity of the solution. In this paper, we investigate the predictability of financial movement direction with SVM by forecasting the weekly movement direction of NIKKEI 225 index. To evaluate the forecasting ability of SVM, we compare the performance with those of Linear Discriminant Analysis, Quadratic Discriminant Analysis and Elman Backpropagation Neural Networks. The experiment results show that SVM outperforms other classification methods. Furthermore, we propose a combining model by integrating SVM with other classification methods. The combining model performs the best among the forecasting methods.

  6. 48 CFR 752.225-9 - Buy American Act-Trade Agreements Act-Balance of Payments Program.

    Science.gov (United States)

    2010-10-01

    ... Agreements Act-Balance of Payments Program. 752.225-9 Section 752.225-9 Federal Acquisition Regulations... CLAUSES Texts of Provisions and Clauses 752.225-9 Buy American Act—Trade Agreements Act—Balance of Payments Program. The clause prescribed by FAR 25.408(a)(2) is not generally included in USAID...

  7. 20 CFR 225.35 - When a PIA used in computing a retirement annuity can be increased for DRC's.

    Science.gov (United States)

    2010-04-01

    ... annuity can be increased for DRC's. 225.35 Section 225.35 Employees' Benefits RAILROAD RETIREMENT BOARD... Credits § 225.35 When a PIA used in computing a retirement annuity can be increased for DRC's. Delayed... follows: DRC's earned for month in Are added to PIA Years before the year the employee annuity begins...

  8. 12 CFR 225.112 - Indirect control of small business concern through convertible debentures held by small business...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Indirect control of small business concern through convertible debentures held by small business investment company. 225.112 Section 225.112 Banks... Interpretations § 225.112 Indirect control of small business concern through convertible debentures held by...

  9. Critical temperature of metallic hydrogen sulfide at 225-GPa pressure

    Science.gov (United States)

    Kudryashov, N. A.; Kutukov, A. A.; Mazur, E. A.

    2017-01-01

    The Eliashberg theory generalized for electron—phonon systems with a nonconstant density of electron states and with allowance made for the frequency behavior of the electron mass and chemical potential renormalizations is used to study T c in the SH3 phase of hydrogen sulfide under pressure. The phonon contribution to the anomalous electron Green's function is considered. The pairing within the total width of the electron band and not only in a narrow layer near the Fermi surface is taken into account. The frequency and temperature dependences of the complex mass renormalization Re Z(ω), the density of states N(ɛ) renormalized by the electron—phonon interactions, and the electron—phonon spectral function obtained computationally are used to calculate the anomalous electron Green's function. A generalized Eliashberg equation with a variable density of electron states has been solved. The frequency dependence of the real and imaginary parts of the order parameter in the SH3 phase has been obtained. The value of T c ≈ 177 K in the SH3 phase of hydrogen sulfide at pressure P = 225 GPa has been determined by solving the system of Eliashberg equations.

  10. Laser trapping of Ra-225 and Ra-226 and progress towards an electric dipole moment measurement

    Science.gov (United States)

    Guest, J. R.; Scielzo, N. D.; Ahmad, I.; Bailey, K.; Greene, J. P.; Holt, R. J.; Lu, Z.-T.; O'Connor, T. P.; Potterveld, D. H.

    2006-10-01

    Permanent electric dipole moments (EDMs) in atoms or molecules are signatures of Time (T)-and Parity (P)-violation and represent an important window onto physics beyond the Standard Model. We are developing a next generation EDM search around laser-cooled and trapped Ra-225 (t1/2 = 15 d). Due to octupole deformation of the nucleus, Ra-225 is predicted to be two to three orders of magnitude more sensitive to T-violating interactions than Hg-199, which currently sets the most stringent limits in the nuclear sector. We will discuss our progress, including the successful laser cooling and trapping of Ra-225 and Ra-226 atoms. We have demonstrated transverse cooling, Zeeman slowing, and capture of Ra-225 and Ra-226 atoms in a magneto-optical trap (MOT). By driving a second atomic transition, we have extended the lifetime of the trap from milliseconds to seconds and performed necessary spectroscopic measurements.

  11. Production of Ac-225 for cancer therapy by photon-induced transmutation of Ra-226.

    Science.gov (United States)

    Melville, G; Meriarty, H; Metcalfe, P; Knittel, T; Allen, B J

    2007-09-01

    The increasing application of Ac-225 for cancer therapy indicates the potential need for its increased production and availability. The production of Ac-225 has been achieved using bremsstrahlung photons from an 18 MV medical linear accelerator (linac) to bombard a Ra-226 target. A linac dose of 2800 Gy produced about 64 microCi of Ra-225, which decays to Ac-225. This result, while consistent with the theoretical calculations, is far too low to be of practical use. A more powerful linac is required that runs at a higher current, longer pulse length and higher frequency for practical production. This process could also lead to the reduction of the nuclear waste product Ra-226.

  12. 78 FR 48647 - Foreign-Trade Zone 225-Springfield, Missouri; Authorization of Production Activity; General...

    Science.gov (United States)

    2013-08-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 225--Springfield, Missouri; Authorization of Production Activity; General Dynamics Ordnance and Tactical Systems Munitions Services (Demilitarization of...

  13. Subgrain edge detection on images of steel 2,25Cr-1Mo using watershed method

    OpenAIRE

    Ivasenko, Iryna; Vorobel, Roman

    2012-01-01

    Method of preliminary image processing based on retinex theory for subgrain edge detection of steel 2,25Cr-1Mo using watershed approach is proposed. Experimental results are presented to demonstrate the effectiveness of proposed approach.

  14. 18 CFR 367.2250 - Account 225, Unamortized premium on long-term debt.

    Science.gov (United States)

    2010-04-01

    ... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Long-Term Debt § 367.2250 Account 225... FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY...

  15. 225m Outdoor W-Band Radio-over-Fiber Link Using an Optical SFP+ Module

    DEFF Research Database (Denmark)

    Rommel, Simon; Rodríguez Páez, Juan Sebastián; Chorchos, Łukasz

    2016-01-01

    A W-band radio-over-fiber link based on a commercial SFP+ module is demonstrated, allowing easy integration into existing PON solutions. Without active laser control good RF frequency stability and 225m wireless distance are achieved......A W-band radio-over-fiber link based on a commercial SFP+ module is demonstrated, allowing easy integration into existing PON solutions. Without active laser control good RF frequency stability and 225m wireless distance are achieved...

  16. 47 CFR 95.225 - (R/C Rule 25) How do I contact the FCC?

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false (R/C Rule 25) How do I contact the FCC? 95.225... (R/C Rule 25) How do I contact the FCC? (a) FCC National Call Center at 1-888-225-5322. (b) FCC World Wide Web homepage: http://www.fcc.gov. (c) In writing, to FCC, Attention: R/C, 1270 Fairfield...

  17. Auricular reconstruction of congenital microtia: personal experience in 225 cases.

    Science.gov (United States)

    Anghinoni, M; Bailleul, C; Magri, A S

    2015-06-01

    Microtia is a congenital disease with various degrees of severity, ranging from the presence of rudimentary and malformed vestigial structures to the total absence of the ear (anotia). The complex anatomy of the external ear and the necessity to provide good projection and symmetry make this reconstruction particularly difficult. The aim of this work is to report our surgical technique of microtic ear correction and to analyse the short and long term results. From 2000 to 2013, 210 patients affected by microtia were treated at the Maxillo-Facial Surgery Division, Head and Neck Department, University Hospital of Parma. The patient population consisted of 95 women and 115 men, aged from 7 to 49 years. A total of 225 reconstructions have been performed in two surgical stages basing of Firmin's technique with some modifications and refinements. The first stage consists in fabrication and grafting of a three-dimensional costal cartilage framework. The second stage is performed 5-6 months later: the reconstructed ear is raised up and an additional cartilaginous graft is used to increase its projection. A mastoid fascial flap together with a skin graft are then used to protect the cartilage graft. All reconstructions were performed without any major complication. The results have been considered satisfactory by all patients starting from the first surgical step. Low morbidity, the good results obtained and a high rate of patient satisfaction make our protocol an optimal choice for treatment of microtia. The surgeon's experience and postoperative patient care must be considered as essential aspects of treatment.

  18. 女性生殖管道发育异常225例临床分析%Clinical analysis of 225 women with congenital uterine malformation

    Institute of Scientific and Technical Information of China (English)

    王世军; Mandakini Oli; 蒋励; 王建六; 魏丽惠

    2008-01-01

    目的 探讨子宫发育异常的发病情况、临床特征、诊治方法及其对生育的影响.方法 选取1990年3月-2005年1月北京大学人民医院收治的子宫发育异常患者225例的临床资料,进行回顾性分析,总结不同类型子宫发育异常的构成比、临床特征、诊治方法及对生育的影响.结果 (1)225例子宫发育异常患者中,中隔子宫125例,占55.6%,其中122例(97.6%,122/125)患者妊娠,但影响其妊娠结局,出现流产、胎位异常、早产、前置胎盘、胎膜早破等并发症.(2)双子宫51例,占22.7%(51/225);其中50例(98%,50/51)患者妊娠,对妊娠无明显影响;5例(10%,5/51)合并泌尿系统畸形.(3)残角子宫26例(11.6%,26/225),发生残角子宫妊娠4例(15%,4/26),残角子宫同侧输卵管妊娠1例(4%,1/26);2例(8%,2/26)合并泌尿系统畸形;合并不孕4例(15%,4/26).(4)双角子宫14例,占6.2%(14/225),无不孕患者,出现早产、胎膜早破等并发症;1例(7%,1/14)合并泌尿系统畸形.(5)其他类型:鞍状子宫4例(1.8%,4/225),无不孕患者;无子宫3例(1.3%,3/225),均以原发闭经就诊;单角子宫2例(0.9%,2/225),均合并不孕.结论 子宫发育异常中以中隔子宫最多见.中隔子宫、双子宫、双角子官、残角子宫、鞍状子宫对生育无明显影响,但在妊娠期可出现不同的并发症.子宫发育异常常合并泌尿系统畸形.无症状的子宫发育异常,可不予处理.%Objective To investigate the prevalence, clinical features, diagnosis, treatment and the influence on procreation of uterine malformation. Methods Totally 225 women with uterine malformation referred to our hospital from Mar 1990 to Jan 2005 were involved in this retrospective analysis.The constituent ratio, clinical feature, diagnosis, treatment and the influence on procreation were analyzed.Results (1) Among 225 cases of uterine malformation, 125 cases (55.6%) were septate uterus; 122(97.6%, 122/125 ) of these patients became pregnant, but

  19. Composite outcomes in 2.25-mm drug eluting stents: a systematic review

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Justin Z. [Department of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ, 85724 (United States); Singh, Nirmal [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Ortega, Gilbert [College of Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Low, See Wei; Kanakadandi, Uday [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Fortuin, F. David [Department of Cardiovascular Diseases, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054 (United States); Lassar, Tom [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Lee, Kwan S., E-mail: klee@shc.arizona.edu [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States)

    2015-06-15

    Background: Coronary atherosclerosis often involves small-caliber coronaries, yet the safety and efficacy of 2.25-mm DES have been poorly defined, with a general lack of separation of 2.25 with 2.5-mm performance. No randomized head-to-head 2.25 mm DES studies have been reported. There are several single-arm prospective studies, and we aim to systematically review all published specific 2.25-mm data to estimate composite DES-specific performance and highlight current knowledge gaps. Methods: We performed a systematic literature search of PubMed, EMBASE, Web of Science and Cochrane database for clinical trials of 2.25-mm DES. Angiographic and composite clinical outcomes were compared with descriptive statistics. Results: 2.25 mm-Paclitaxel (PES), sirolimus (SES), everolimus (EES) and platinum chromium EES DES-specific outcomes have been reported. Death at 12 months for SES, PES, EES and platinum chromium EES was 1.3%, 3.0%, 1.5%, and 4.4%. Rates of target vessel revascularization at 12 months for SES, PES, EES and platinum chromium EES were 5.7%, 13.3%, 8.8%, and 3.3%. Angiographic outcomes at 9 months to one year were as follows: mean late lumen loss (LLL) for SES, PES, and EES was 0.15 ± 0.11-mm, 0.28 ± 0.11-mm, and 0.16 ± 0.41-mm and mean diameter restenosis for SES, PES, and EES were 29.5 ± 6.2%, 34.7 ± 4.2%, and 20.9 ± 22.5%. Reported stent thrombosis rates for 2.25-mm DES were low ranging from 0% to 2.2% in up to 24-months of follow-up. Conclusions: This systematic review summarizes and tabulates all available specific data on 2.25-mm DES. Based on our descriptive analysis, 2.25-mm DESs have a favorable safety and efficacy profile for the treatment of very small coronary lesions. - Highlights: • Safety and efficacy of 2.25-mm DES have been poorly defined. • We performed a systematic review on all published 2.25 mm data to estimate composite DES-specific performance and highlight current knowledge gaps. • We pooled data from 9 clinical studies and 1

  20. 225Ac and 223Ra production via 800 MeV proton irradiation of natural thorium targets.

    Science.gov (United States)

    Weidner, J W; Mashnik, S G; John, K D; Ballard, B; Birnbaum, E R; Bitteker, L J; Couture, A; Fassbender, M E; Goff, G S; Gritzo, R; Hemez, F M; Runde, W; Ullmann, J L; Wolfsberg, L E; Nortier, F M

    2012-11-01

    Cross sections for the formation of (225,227)Ac, (223,225)Ra, and (227)Th via the proton bombardment of natural thorium targets were measured at a nominal proton energy of 800 MeV. No earlier experimental cross section data for the production of (223,225)Ra, (227)Ac and (227)Th by this method were found in the literature. A comparison of theoretical predictions with the experimental data shows agreement within a factor of two. Results indicate that accelerator-based production of (225)Ac and (223)Ra is a viable production method.

  1. {225}γ habit planes in martensitic steels: from the PTMC to a continuous model

    Science.gov (United States)

    Baur, Annick P.; Cayron, Cyril; Logé, Roland E.

    2017-01-01

    Fine twinned microstructures with {225}γ habit planes are commonly observed in martensitic steels. The present study shows that an equibalanced combination of twin-related variants associated to the Kurdjumov-Sachs orientation relationship is equivalent to the Bowles and Mackenzie’s version of the PTMC for this specific {225}γ case. The distortion associated to the Kurdjumov-Sachs orientation relationship results from a continuous modeling of the FCC-BCC transformation. Thus, for the first time, an atomic path can be associated to the PTMC. PMID:28106127

  2. 12 CFR 225.23 - Expedited action for certain nonbanking proposals by well-run bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Expedited action for certain nonbanking proposals by well-run bank holding companies. 225.23 Section 225.23 Banks and Banking FEDERAL RESERVE SYSTEM....23 Expedited action for certain nonbanking proposals by well-run bank holding companies. (a)...

  3. 12 CFR 225.14 - Expedited action for certain bank acquisitions by well-run bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Expedited action for certain bank acquisitions by well-run bank holding companies. 225.14 Section 225.14 Banks and Banking FEDERAL RESERVE SYSTEM... certain bank acquisitions by well-run bank holding companies. (a) Filing of notice—(1)...

  4. 22 CFR 225.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Science.gov (United States)

    2010-04-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 225.120 Section 225... Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. The department or agency head will evaluate all applications and...

  5. 48 CFR 225.770 - Prohibition on acquisition of United States Munitions List items from Communist Chinese military...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Prohibition on acquisition of United States Munitions List items from Communist Chinese military companies. 225.770 Section 225... of United States Munitions List items from Communist Chinese military companies. This...

  6. 48 CFR 252.225-7007 - Prohibition on Acquisition of United States Munitions List Items from Communist Chinese Military...

    Science.gov (United States)

    2010-10-01

    ... Regulation in 22 CFR Part 121. (b) Any supplies or services covered by the United States Munitions List that... of United States Munitions List Items from Communist Chinese Military Companies. 252.225-7007 Section... Chinese Military Companies. As prescribed in 225.1103(4), use the following clause: Prohibition...

  7. A theoretical model for the production of Ac-225 for cancer therapy by neutron capture transmutation of Ra-226.

    Science.gov (United States)

    Melville, G; Melville, P

    2013-02-01

    Radium needles that were once implanted into tumours as a cancer treatment are now obsolete and constitute a radioactive waste problem, as their half-life is 1600 years. We are investigating the reduction of radium by transmutation by bombarding Ra-226 with high-energy neutrons from a neutron source to produce Ra-225 and hence Ac-225, which can be used as a generator to produce Bi-213 for use in 'Targeted Alpha Therapy' for cancer. This paper examines the possibility of producing Ac-225 by neutron capture using a theoretical model in which neutron energy is convoluted with the corresponding neutron cross sections of Ra-226. The total integrated yield can then be obtained. This study shows that an intense beam of high-energy neutrons could initiate neutron capture on Ra-226 to produce Ra-225 and hence practical amounts of Ac-225 and a useful reduction of Ra-226.

  8. A=225 implantation for $^{221}$Fr source for TRIUMF atom trap

    CERN Multimedia

    The FrPNC Collaboration is mounting an atom trap for parity violation experiments and precision spectroscopy on francium atoms at TRIUMF's ISAC facility. We would like to use ISOLDE's capability of simultaneously implanting A=225 (while another experiment runs online) to make a long-lived source feeding $^{221}$Fr for tests of the trap. $^{225}$Ra $\\beta$-decays to $^{225}$Ac, which then $\\alpha$-decays, producing 100 keV $^{221}$Fr t$_{1/2}$= 4.8 minute recoils. The implanted A=225 source would be shipped to TRIUMF, where it would be held for several minutes at a time a few mm from the same yttrium foil that normally receives the ISAC beam. SRIM calculations imply that 20% of the $^{221}$Fr will be implanted in a 1 cm diameter spot on the yttrium. Then the yttrium foil is moved to the trap and heated to release the Fr atoms, just as in normal ISAC online operation. A test implantation will be done at 10$^{7}$/sec production for 1 day, testing whether carbon cracking on the implantation foil in the mass separ...

  9. 13 CFR 113.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Educational institutions eligible... Receiving Federal Financial Assistance Coverage § 113.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§...

  10. 18 CFR 1317.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-04-01

    ... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 1317.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which...) Provision for transition plans. An educational institution to which this section applies shall...

  11. 45 CFR 2555.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Educational institutions eligible to submit... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 2555.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to...

  12. 49 CFR 25.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Educational institutions eligible to submit... Coverage § 25.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 25.300 through 25.310 apply that: (1)...

  13. 41 CFR 101-4.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Educational institutions... Coverage § 101-4.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 101-4.300 through 101-4.310 apply that:...

  14. 14 CFR 1253.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Educational institutions eligible to submit... FINANCIAL ASSISTANCE Coverage § 1253.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 1253.300 through 1253.310...

  15. 45 CFR 618.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Educational institutions eligible to submit... RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 618.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§...

  16. 6 CFR 17.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Educational institutions eligible to submit... FINANCIAL ASSISTANCE Coverage § 17.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 17.300 through 17.310 apply...

  17. 10 CFR 1042.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Educational institutions eligible to submit transition... § 1042.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 1042.300 through 1042.310 apply that: (1)...

  18. 40 CFR 5.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Educational institutions eligible to... FINANCIAL ASSISTANCE Coverage § 5.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 5.300 through 5.310 apply...

  19. 24 CFR 3.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Educational institutions eligible... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 3.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to...

  20. 15 CFR 8a.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Educational institutions eligible to... FINANCIAL ASSISTANCE Coverage § 8a.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 8a.300 through 8a.310 apply...

  1. 43 CFR 41.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Educational institutions eligible to... FINANCIAL ASSISTANCE Coverage § 41.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 41.300 through 41.310 apply...

  2. 32 CFR 196.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Educational institutions eligible to submit... OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 196.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational...

  3. 36 CFR 1211.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Educational institutions... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 1211.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational...

  4. 28 CFR 54.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Educational institutions eligible to... Coverage § 54.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 54.300 through 54.310 apply that: (1)...

  5. 31 CFR 28.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Educational institutions eligible to... FINANCIAL ASSISTANCE Coverage § 28.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 28.300 through 28.310 apply...

  6. 38 CFR 23.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Educational institutions... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 23.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to...

  7. 22 CFR 146.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Educational institutions eligible to submit... Coverage § 146.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 146.300 through 146.310 apply that:...

  8. 22 CFR 229.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Educational institutions eligible to submit... Coverage § 229.225 Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 229.300 through 229.310 apply that:...

  9. 25 CFR 225.35 - Inspection of premises; books and accounts.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises; books and accounts. 225.35...; books and accounts. (a) Operators shall allow Indian mineral owners, their authorized representatives... submit all related reports required by the minerals agreement and applicable regulations. Books...

  10. 78 FR 6845 - Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    Science.gov (United States)

    2013-01-31

    ... Federal Aviation Administration Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S..., working group meetings, and document preparation. Establish agenda for next Plenary. Review Progress...

  11. 76 FR 6180 - First Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    Science.gov (United States)

    2011-02-03

    ... No: 2011-2318] DEPARTMENT OF TRANSPORTATION Federal Aviation Administration First Meeting: RTCA...: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting..., review progress and actions Other Business Establish Agenda for Next Meeting Date and Place of...

  12. 20 CFR 225.23 - Combined Earnings PIA used in survivor annuities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Combined Earnings PIA used in survivor... RAILROAD RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS PIA's Used in Computing Survivor Annuities and the Amount of the Residual Lump-Sum Payable § 225.23 Combined Earnings PIA used in...

  13. 20 CFR 225.25 - RR Earnings PIA used in survivor annuities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false RR Earnings PIA used in survivor annuities... RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS PIA's Used in Computing Survivor Annuities and the Amount of the Residual Lump-Sum Payable § 225.25 RR Earnings PIA used in survivor annuities. The...

  14. 20 CFR 225.24 - SS Earnings PIA used in survivor annuities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false SS Earnings PIA used in survivor annuities... RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS PIA's Used in Computing Survivor Annuities and the Amount of the Residual Lump-Sum Payable § 225.24 SS Earnings PIA used in survivor annuities. The...

  15. 20 CFR 225.22 - Employee RIB PIA used in survivor annuities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Employee RIB PIA used in survivor annuities... RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS PIA's Used in Computing Survivor Annuities and the Amount of the Residual Lump-Sum Payable § 225.22 Employee RIB PIA used in survivor annuities....

  16. 12 CFR 225.127 - Investment in corporations or projects designed primarily to promote community welfare.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Investment in corporations or projects designed... equity and debt investments in corporations or projects designed primarily to promote community welfare... not intended to limit projects under § 225.25(b)(6) to that area. Other investments primarily...

  17. 48 CFR 52.225-17 - Evaluation of Foreign Currency Offers.

    Science.gov (United States)

    2010-10-01

    ... Clauses 52.225-17 Evaluation of Foreign Currency Offers. As prescribed in 25.1103(c), insert the following provision: Evaluation of Foreign Currency Offers (FEB 2000) If the Government receives offers in more than one currency, the Government will evaluate offers by converting the foreign currency to United...

  18. 40 CFR 795.225 - Dermal pharmacokinetics of DGBE and DGBA.

    Science.gov (United States)

    2010-07-01

    ... shaven skin. (iii) Washing efficiency study. Before initiation of the dermal absorption studies described... Guidelines § 795.225 Dermal pharmacokinetics of DGBE and DGBA. (a) Purpose. The purpose of these studies is... in percutaneous absorption studies. (ii) Animals. Adult female Sprague Dawley rats shall be used....

  19. 33 CFR 150.225 - What training and instruction are required?

    Science.gov (United States)

    2010-07-01

    ... hold. Procedures for documenting employee training must be outlined in the operations manual. ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What training and instruction are... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Personnel § 150.225 What training...

  20. 33 CFR 157.225 - Dedicated clean ballast tanks operations: General.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Dedicated clean ballast tanks... VESSELS CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels Dedicated Clean Ballast Tanks Operations § 157.225 Dedicated clean ballast tanks operations: General. The master of a tank vessel...

  1. 48 CFR 225.7006-4 - Solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... and contract clause. (a) Use the provision at 252.225-7037, Evaluation of Offers for Air Circuit Breakers, in solicitations requiring air circuit breakers for naval vessels unless— (1) An exception... Breakers, in solicitations and contracts requiring air circuit breakers for naval vessels unless— (1)...

  2. 17 CFR 256.225 - Unamortized premium on long-term debt.

    Science.gov (United States)

    2010-04-01

    ... COMMISSION (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 6. Long-Term Debt § 256.225 Unamortized premium on... distribute the amount equitably over the life of the security. The amortization shall be on a monthly...

  3. CCD UBV Photometry and Kinematics of the Open Cluster NGC 225

    CERN Document Server

    Bilir, S; Yontan, T; Guver, T; Bakis, V; Ak, T; Ak, S; Paunzen, E; Eker, Z

    2016-01-01

    We present the results of CCD $UBV$ photometric and spectroscopic observations of the open cluster NGC 225. In order to determine the structural parameters of NGC 225, we calculated the stellar density profile in the cluster's field. We estimated the probabilities of the stars being physical members of the cluster using the existing astrometric data. The most likely members of the cluster were used in the determination of the astrophysical parameters of the cluster. We calculated the mean radial velocity of the cluster as $V_{r}=-8.3\\pm 5.0$ km s$^{-1}$ from the optical spectra of eight stars in the cluster's field. Using the U-B vs B-V two-colour diagram and UV excesses of the F-G type main-sequence stars, the reddening and metallicity of NGC 225 were inferred as $E(B-V)=0.151\\pm 0.047$ mag and $[Fe/H]=-0.11\\pm 0.01$ dex, respectively. We fitted the colour-magnitude diagrams of NGC 225 with the PARSEC isochrones and derived the distance modulus, distance and age of the cluster as $\\mu_{V}=9.3\\pm 0.07$ mag, d...

  4. 48 CFR 225.872-7 - Industrial security for qualifying countries.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial security for... Agreements and Coordination 225.872-7 Industrial security for qualifying countries. The required procedures... qualifying country sources are in the DoD Industrial Security Regulation DoD 5220.22-R (implemented for...

  5. 48 CFR 252.225-7024 - Requirement for products or services from Iraq or Afghanistan.

    Science.gov (United States)

    2010-10-01

    ... products or services from Iraq or Afghanistan. As prescribed in 225.7703-5(b), use the following clause: Requirement for Products or Services From Iraq or Afghanistan (SEP 2008) (a) Definitions. As used in this... shall provide only products from Iraq or Afghanistan or services from Iraq or Afghanistan under...

  6. The feasibility of [sup 225]Ac as a source of [alpha]-particles in radioimmunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Geerlings, M.W.; Hout, R. van der (Akzo nv, Arnhem (Netherlands)); Kaspersen, F.M. (Organon International bv, Oss (Netherlands)); Apostolides, C. (Commission of the European Communities, Karlsruhe (Germany). European Inst. for Transuranium Elements)

    1993-02-01

    This paper proposes the utilization of [sup 225]Ac for the [alpha]-radioimmunotherapy of cancer. The isotope decays with a radioactive half-life of 10 days into a cascade of short-lived [alpha]-and [beta]-emitting isotopes. In addition, when indicated by the pharmacokinetic requirements of particular clinical applications, [sup 213]Bi, with a radioactive half-life of 47 min, can be chosen as an alternative source of [alpha]-particles in radioimmunotherapy. This isotope is the last [alpha] emitter in the [sup 225]Ac decay-cascade and can be extracted from a [sup 225]Ac source at the bedside of the patient. [sup 225]Ac can quasi ad infinitum be obtained from one of its precursors, [sup 229]Th, which can be made available by various means. The indications for the use of [alpha]-particles as an alternative to more traditional classes of radiation are derived from the particle-kinetic characteristics and the radioactive half-life of their source isotope, as well as from the properties of the target-selective carrier moiety for the source isotope. It may be expected that useful applications, complementary to and/or in conjunction with other means of therapy will be identified. (author).

  7. 27 CFR 70.225 - Suspension of running of period of limitation; assets of taxpayer in control or custody of court.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Suspension of running of period of limitation; assets of taxpayer in control or custody of court. 70.225 Section 70.225 Alcohol... (Occupational) Tax Limitations § 70.225 Suspension of running of period of limitation; assets of taxpayer...

  8. 40 CFR 1054.225 - How do I amend my application for certification to include new or modified engines or fuel...

    Science.gov (United States)

    2010-07-01

    ... certification to include new or modified engines or fuel systems or change an FEL? 1054.225 Section 1054.225....225 How do I amend my application for certification to include new or modified engines or fuel systems... include new or modified engine or fuel-system configurations, subject to the provisions of this...

  9. Vibration Maintenance of EC-225 Helicopter Main Rotor Blade%EC-225直升机主桨叶振动维护

    Institute of Scientific and Technical Information of China (English)

    钟恢芳

    2013-01-01

      长期过大的振动将加速直升机部件的疲劳损伤,振动维护的目标就是将振动控制在最小范围内,从而保证部件及机体结构的持续有效性。本文从桨叶锥体的角度出发,结合维护操作手册,研究了EC-225直升机主桨叶振动的维护方法。

  10. Levels in 221Fr fed by the α decay of 225Ac

    Science.gov (United States)

    Ardisson, G.; Gasparro, J.; Barci, V.; Sheline, R. K.

    2000-12-01

    The α decay of 225Ac to 221Fr was reinvestigated by γ-ray spectroscopic studies with HPGe detectors and 225Ac sources purified using continuous elution processes. Energies and intensities of about 120 γ-ray transitions were measured. Among these, 40 are reported for the first time. A 221Fr level scheme with 46 excited states and 124 transitions is proposed. The level structure is described in terms of a reflection asymmetric structure with parity doublet bands Kπ=1/2+/-, 3/2+/-, 5/2+/-, and 3/2+/- in order of increasing energy. Both strong and intermediate coupling models have been shown to be in good agreement with the experimental data.

  11. New measurement of exotic decay of 225Ac by 14C emission

    Science.gov (United States)

    Guglielmetti, A.; Bonetti, R.; Ardisson, G.; Barci, V.; Giles, T.; Hussonnois, M.; Le Du, J. F.; Le Naour, C.; Mikheev, V. L.; Pasinetti, A. L.; Ravn, H. L.; Tretyakova, S. P.; Trubert, D.

    The branching ratio of 225Ac decay by emission of 14C was remeasured under improved experimental conditions by using a radioactive source produced at the ISOLDE mass-separator at CERN and a nuclear track detector technique. The result, B = λ14C/λα = (4.5+/-1.4)10-12, is consistent with the anomalously high value obtained in the 1993 experiment, thus confirming the importance of nuclear-structure effects in this exotic decay.

  12. Wind turbine test Vestas V27-225 kW

    Energy Technology Data Exchange (ETDEWEB)

    Markkilde Petersen, S.

    1990-10-15

    The report describes fundamental measurements performed on a Vestas-V27-225 kW pitch regulated wind turbine. The measurements carried out and reported here comprises the power output, system efficiency, energy production, transmission efficiency, rotor power, rotor efficiency, air-brakes efficiency, structural dynamics, loads at cut-in and braking, yaw error statistics, flapwise root bending moment and rotor thrust. (author).

  13. Functionalized NaA nanozeolites labeled with {sup 224,225}Ra for targeted alpha therapy

    Energy Technology Data Exchange (ETDEWEB)

    Piotrowska, Agata, E-mail: a.kasperek@ichtj.waw.pl; Leszczuk, Edyta [Institute of Nuclear Chemistry and Technology (Poland); Bruchertseifer, Frank; Morgenstern, Alfred [Joint Research Centre – European Commission, Institute for Transuranium Elements (Germany); Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology (Poland)

    2013-11-15

    The {sup 223}Ra, {sup 224}Ra, and {sup 225}Ra radioisotopes exhibit very attractive nuclear properties for application in radionuclide therapy. Unfortunately the lack of appropriate bifunctional ligand for radium is the reason why these radionuclides have not found application in receptor-targeted therapy. In the present work, the potential usefulness of the NaA nanozeolite as a carrier for radium radionuclides has been studied. {sup 224}Ra and {sup 225}Ra, α-particle emitting radionuclides, have been absorbed in the nanometer-sized NaA zeolite (30–70 nm) through simple ion exchange. {sup 224,225}Ra-nanozeolites exhibited very high stability in solutions containing physiological salt, EDTA, amino acids, and human serum. To make NaA nanozeolite particles dispersed in water their surface was modified with a silane coupling agent containing poly(ethylene glycol) molecules. This functionalization approach let us covalently attach a biomolecule to the NaA nanozeolite surface.

  14. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Directory of Open Access Journals (Sweden)

    R. Dubey

    2016-01-01

    Full Text Available Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F+206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30–50 MeV.

  15. Safety experience with IMC-C225, an anti-epidermal growth factor receptor antibody.

    Science.gov (United States)

    Needle, Michael N

    2002-10-01

    In phase II trials, the anti-epidermal growth factor receptor antibody IMC-C225 did not appear to significantly exacerbate the common toxicities associated with cytotoxic chemotherapy when combined with standard anticancer treatments in patients with colorectal cancer, squamous cell carcinoma of the head and neck, or pancreatic cancer. The most common treatment-related adverse events reported during therapy with IMC-C225 were an acne-like rash and hypersensitivity reactions. The acne-like rash appeared as a sterile, suppurative form of folliculitis, commonly starting on the face, scalp, chest, and upper back. It resolved without scarring once treatment was stopped. Notably, the appearance of acne-like rash, particularly grade 3, was associated with higher treatment responses in patients with refractory colorectal cancer. The hypersensitivity reactions occurred less often than acne-like rash. They responded to standard treatments and were less common after the first dose. In summary, IMC-C225 is generally well tolerated as a single agent and when combined with chemotherapy or radiotherapy and possesses a manageable toxicity profile.

  16. NOAA TIFF Image- 5m Bathymetry (Sun Illuminated- Azimuth 225) of St. Croix (Buck Island), US Virgin Islands, 2004

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This georeferenced image represents 5 meter resolution bathymetry (sun illuminated with azimuth 225 and incline 45) of the north shore of St. Croix, US Virgin...

  17. Development of a Complex Geometry Standard Fixture and Solvent Evaluation Method fo Assessing Replacement Solvents for AK-225G Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The focus of this analysis was the development of a complex geometry test fixture and test method for determining solvent cleaning efficiency. AK-225 belongs to a...

  18. 225例闭经患者染色体核型分析及临床意义%Chromosome karyotypte and clinical analyse in 225 amenorrheas

    Institute of Scientific and Technical Information of China (English)

    郑燕銮; 徐岚; 张新能

    2015-01-01

    目的:分析原发闭经和继发闭经患者的染色体异常情况并探讨其临床意义。方法抽取患者外周血培养,制备染色体,采用G显带分析。结果225例原发闭经和继发闭经患者,共检出异常核型63例,占28%。其中,原发闭经患者148例,异常核型55例,占37.16%。继发闭经患者77例,核型异常8例,占10.39%。结论染色体异常是导致原发闭经和继发闭经的主要原因,对闭经患者进行染色体检查,明确闭经原因,及早对症治疗有重要意义。%Objective To analyse the suffer′excrescent circumstance in chromosome who are primary amenorrhea or secondary amenorrhea and inquiry its clinical meaning .Methods Take out patients′peypheyal vein blood to cultuve ,the chromosome was pre‐pared ,G band was analysed .Results primary amenorrhea or secondary amenorrhea suffer totally 225 ,there were 63 with chromo‐som abnormal karyotyptes which occupies 28% ;Among 148 the patiens of primary amenorrhea ,chromosom abnormal karyotyptes were 55 examples which occupies 37 .16% ,secondary amenorrhea is 77 examples ,chromosom abnormal karyotyptes were 8 exam‐ples which occupies 10 .39% .Conclusion Chromosome abnormals are the main cause of primary amenorrhea and secondary amen‐orrhea .in patients with chromosom analyse ,to kncw the cause of amenorrhea ,early symptomatic treatment is important .

  19. Stripe conductivity in La1.775Sr0.225NiO4

    Science.gov (United States)

    Pashkevich; Blinkin; Gnezdilov; Tsapenko; Eremenko; Lemmens; Fischer; Grove; Guntherodt; Degiorgi; Wachter; Tranquada; Buttrey

    2000-04-24

    We report Raman light-scattering and optical conductivity measurements on a single crystal of La1.775Sr0.225NiO4 which exhibits incommensurate charge-stripe order. The extra phonon peaks induced by stripe order can be understood in terms of the energies of phonons that occur at the charge-order wave vector Q(c). A strong Fano antiresonance for a Ni-O bond-stretching mode provides clear evidence for finite dynamical conductivity within the charge stripes.

  20. Stripe Conductivity in La1.775Sr0.225NiO4

    Science.gov (United States)

    Pashkevich, Yu. G.; Blinkin, V. A.; Gnezdilov, V. P.; Tsapenko, V. V.; Eremenko, V. V.; Lemmens, P.; Fischer, M.; Grove, M.; Güntherodt, G.; Degiorgi, L.; Wachter, P.; Tranquada, J. M.; Buttrey, D. J.

    2000-04-01

    We report Raman light-scattering and optical conductivity measurements on a single crystal of La1.775Sr0.225NiO4 which exhibits incommensurate charge-stripe order. The extra phonon peaks induced by stripe order can be understood in terms of the energies of phonons that occur at the charge-order wave vector Qc. A strong Fano antiresonance for a Ni-O bond-stretching mode provides clear evidence for finite dynamical conductivity within the charge stripes.

  1. Production of chi mesons in 225 GeV/c. pi. /sup -/Be interactions

    Energy Technology Data Exchange (ETDEWEB)

    Hossain, S.

    1981-09-01

    Gamma rays associated with psi mesons have been studied in 225 GeV/c ..pi../sup -/Be interactions. The psi-..gamma.. mass spectrum shows an excess of 47 +- 11 events above background centered at 3.531 GeV/c/sup 2/ with an rms width of 22.4 MeV. Attributing this excess of events to the decay chi ..-->.. psi ..gamma.. implies that 38 +- 9 % of all psi mesons are produced by this mechanism. The experimental setup and results are detailed.

  2. Cavity design and linear analysis of 225 GHz frequency-quadrupling gyroklystron

    Institute of Scientific and Technical Information of China (English)

    Liu Di-Wei; Yuan Xue-Song; Yan Yang; Liu Sheng-Gang

    2009-01-01

    This paper considers the frequency-quadrupling three-cavity gyroklystrons with successive frequency-doubling in each cavity. The cavities of 225 GHz frequency-quadrupling gyroklystron are designed with the scattering matrices method and the possible operating mode are discussed. With the point-gap theory, the starting currents of the possible operating modes and the potential parasitic modes in the output cavity are calculated. The optimal operating mode is proposed under consideration of the mode competition and the power capacity of the cavity.

  3. 22.5% efficient silicon heterojunction solar cell with molybdenum oxide hole collector

    Energy Technology Data Exchange (ETDEWEB)

    Geissbühler, Jonas, E-mail: jonas.geissbuehler@epfl.ch; Werner, Jérémie; Martin de Nicolas, Silvia; Hessler-Wyser, Aïcha; Tomasi, Andrea; Niesen, Bjoern; De Wolf, Stefaan [Photovoltaics and Thin Film Electronics Laboratory, Institute of Microengineering (IMT), École Polytechnique Fédérale de Lausanne (EPFL), Rue de la Maladière 71b, CH-2000 Neuchâtel (Switzerland); Barraud, Loris; Despeisse, Matthieu; Nicolay, Sylvain [CSEM PV-Center, Jaquet-Droz 1, CH-2000 Neuchâtel (Switzerland); Ballif, Christophe [Photovoltaics and Thin Film Electronics Laboratory, Institute of Microengineering (IMT), École Polytechnique Fédérale de Lausanne (EPFL), Rue de la Maladière 71b, CH-2000 Neuchâtel (Switzerland); CSEM PV-Center, Jaquet-Droz 1, CH-2000 Neuchâtel (Switzerland)

    2015-08-24

    Substituting the doped amorphous silicon films at the front of silicon heterojunction solar cells with wide-bandgap transition metal oxides can mitigate parasitic light absorption losses. This was recently proven by replacing p-type amorphous silicon with molybdenum oxide films. In this article, we evidence that annealing above 130 °C—often needed for the curing of printed metal contacts—detrimentally impacts hole collection of such devices. We circumvent this issue by using electrodeposited copper front metallization and demonstrate a silicon heterojunction solar cell with molybdenum oxide hole collector, featuring a fill factor value higher than 80% and certified energy conversion efficiency of 22.5%.

  4. New measurement of exotic decay of {sup 225}Ac by {sup 14}C emission

    Energy Technology Data Exchange (ETDEWEB)

    Guglielmetti, A.; Bonetti, R. [Istituto di Fisica Generale Applicata dell' Universita di Milano (Italy); Istituto Nazionale di Fisica Nucleare, Milan (Italy); Ardisson, G.; Barci, V. [Lab. de Radiochimie, Universite de Nice Sophia-Antipolis, Nice (France); Giles, T.; Ravn, H.L. [CERN, EP Division, Geneva (Switzerland); Hussonnois, M.; Le Du, J.F.; Le Naour, C.; Trubert, D. [Institut de Physique Nucleaire, Orsay (France); Mikheev, V.L.; Tretyakova, S.P. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Pasinetti, A.L. [Istituto di Fisica Generale Applicata dell' Universita di Milano (Italy)

    2001-12-01

    The branching ratio of {sup 225}Ac decay by emission of {sup 14}C was remeasured under improved experimental conditions by using a radioactive source produced at the ISOLDE mass-separator at CERN and a nuclear track detector technique. The result, B={lambda}{sup 14C}/{lambda}{sub {alpha}}=(4.5{+-}1.4)10{sup -12}, is consistent with the anomalously high value obtained in the 1993 experiment, thus confirming the importance of nuclear-structure effects in this exotic decay. (orig.)

  5. New measurement of exotic decay of $^{225}$Ac by $^{14}$C emission

    CERN Document Server

    Guglielmetti, A; Ardisson, G; Barci, V; Giles, T; Hussonnois, M; Le Dû, J F; Le Naour, C; Mikheev, V L; Pasinetti, A L; Ravn, H L; Tretyakova, S P; Trubert, D

    2001-01-01

    The branching ratio of $^{225}$Ac decay by emission of $^{14}$C was remeasured under improved experimental conditions by using a radioactive source produced at the ISOLDE mass-separator at CERN and a nuclear track detector technique. The result, B=$\\lambda_{^{14}\\textrm{C}} / \\lambda_{\\alpha} = (4.5 \\pm 1.4) 10^{-12}$, is consistent with the anomalously high value obtained in the 1993 experiment thus confirming the importance of nuclear structure effects in this exotic decay.

  6. Clinical analysis of 225 cases of sublingual gland cyst%225例舌下腺囊肿临床分析

    Institute of Scientific and Technical Information of China (English)

    刘蕾; 王祥军; 谢卫红; 李新明

    2012-01-01

    Objective To summarize the clinical diagnosis,treatment and prognosis of different types of sublingual gland cyst.Methods The clinical data of 225 cases of sublingual gland cyst from Feb,2001 to May,2011 were retrospectively analyzed.Results Out of the 225 cases,simple cyst accounted for 66.7%,plunge ranula for 21.8% and hybrid cyst accounted for 11.5%,the accuracy rate of diagnosis was 96.9%.Relapse rate was 0.4%.Conclusions Puncture examinations are essential in the diagnosis of simple cyst and hybrid cyst.Color Doppler,puncture examination and symptom are essential in the diagnosis of plunge ranula.The key to successful management for sublingual gland cyst is the excision of related sublingual gland,with the intra oral approach.%目的 初步总结不同类型舌下腺囊肿的诊断,治疗及预后.方法 对2001年2月至2011年5月11年间经口腔颌面外科手术治疗有完整资料的225例舌下腺囊肿患者的临床资料进行总结,对其类型比例、年龄分布,诊断方式及治疗方式进行回顾性分析.结果 总结不同类型舌下腺囊肿的比例为单纯型占66.7%,口外型占21.8%,哑铃型占11.5%.青年人多发.诊断以穿刺为主,口外型穿刺加超声检查,准确率96.9%.治疗以口内切口行腺体及与其相粘连的囊肿摘除为主要治疗方式,对口外型囊肿行口内或口内口外联合切口手术切除,术后术区加压包扎3~7d.术后复发1例,复发率为0.4%.结论 单纯型及哑铃型采取穿刺检查为常规诊断方式,口外型需穿刺加彩超检查并结合临床表现为诊断方式,行口内切口完整摘除舌下腺手术是根治舌下腺囊肿避免复发的关键.

  7. A theoretical model for the production of Ac-225 for cancer therapy by photon-induced transmutation of Ra-226.

    Science.gov (United States)

    Melville, G; Fan Liu, Sau; Allen, B J

    2006-09-01

    Radium needles that were once implanted into tumours as a cancer treatment are now obsolete and constitute a radioactive waste problem, as their half-life is 1600 years. We are investigating the reduction of radium by transmutation on a small scale by bombarding Ra-226 with high-energy photons from a medical linear accelerator (linac) to produce Ra-225, which subsequently decays to Ac-225, which can be used as a generator to produce Bi-213 for use in 'targeted alpha therapy' for cancer. This paper examines the possibility of producing Ac-225 with a linac using an accurate theoretical model in which the bremsstrahlung photon spectrum at 18 MV linac electron energy is convoluted with the corresponding photonuclear cross sections of Ra-226. The total integrated yield can then be obtained and is compared with a computer simulation. This study shows that at 18 MV, the photonuclear reaction on Ra-226 can produce low activities of Ac-225 with a linac. However, a high power linac with high current, pulse length and frequency is needed to produce practical amounts of Ac-225 and a useful reduction of Ra-226.

  8. Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200 MeV.

    Science.gov (United States)

    Weidner, J W; Mashnik, S G; John, K D; Hemez, F; Ballard, B; Bach, H; Birnbaum, E R; Bitteker, L J; Couture, A; Dry, D; Fassbender, M E; Gulley, M S; Jackman, K R; Ullmann, J L; Wolfsberg, L E; Nortier, F M

    2012-11-01

    Cross sections for (223,)(225)Ra, (225)Ac and (227)Th production by the proton bombardment of natural thorium targets were measured at proton energies below 200 MeV. Our measurements are in good agreement with previously published data and offer a complete excitation function for (223,)(225)Ra in the energy range above 90 MeV. Comparison of theoretical predictions with the experimental data shows reasonable-to-good agreement. Results indicate that accelerator-based production of (225)Ac and (223)Ra below 200 MeV is a viable production method.

  9. Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200 MeV

    CERN Document Server

    Weidner, J W; John, K D; Hemez, F; Ballard, B; Bach, H; Birnbaum, E R; Bitteker, L J; Couture, A; Dry, D; Fassbender, M E; Gulley, M S; Jackman, K R; Ullmann, J L; Wolfsberg, L E; Nortier, F M

    2012-01-01

    Cross sections for 223,225Ra, 225Ac and 227Th production by the proton bombardment of natural thorium targets were measured at proton energies below 200 MeV. Our measurements are in good agreement with previously published data and offer a complete excitation function for 223,225Ra in the energy range above 90 MeV. Comparison of theoretical predictions with the experimental data shows reasonable-to-good agreement. Results indicate that accelerator-based production of 225Ac and 223Ra below 200 MeV is a viable production method.

  10. Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging

    Institute of Scientific and Technical Information of China (English)

    Dongbo Lin; Chunli Chen; Guangyuaa Hu; Qi Mei; Hong Qiu; Guoxian Long; Guoqing Hu

    2011-01-01

    An accurate definition of clinical target volume (CTV) is essential for the application of radiotherapy in nasopharvngeai carcinoma (NPC) treatment. A novel epidermal growth factor receptor (EGFR)-targeting contrast agent (C225-USPIO) was designed by conjugating ultrasmail superparamagnetic iron oxide (USPIO) nanoparticles with cetuximab (C225), to non-invasively define the CTV of tumor. The immunobinding activity of C225-USPIO to NPC cell line CNEI was confirmed by flow cytometry and immunofluorescence. The time-dependent accumulation of C225-USPIO in CNE1 cells was evaluated using Prussian blue staining. Targeted internalization and subcellular localization of C225-USPIO was confirmed by transmission electron microscope. The results indicated that C225-USPIO specifically bound to EGFR on the surface of CNEI cells and was taken up into the cell. The uptake of C225-USPIO by CNE1 cells increased significantly with time, when compared with human IgG-USPIO. In addition, 4.7 T magnetic resonance imaging (MRI) revealed that C225-USPIO had a capacity to accumulate in the CNE1 cells, with a resultant marked decrease in MRI T2-weighted signal intensity over time. These findings imply that C225-USPIO has the potential as an MRI contrast agent and can be employed to non-invasively detect early-stage NPC with EGFR overexpression. This provides sufficient theoretical basis for commencing in vivo experiments with the compound.

  11. 225例成人麻疹临床特征及流行病学分析%Clinical features and epidemiological analysis of measles in 225 adult patients

    Institute of Scientific and Technical Information of China (English)

    卫峥; 张建中; 徐天敏

    2012-01-01

    目的 分析总结成人麻疹的临床特征,为临床工作积累经验.方法 回顾性分析2007年1月至2011年1月我院诊治的225例成人麻疹患者发病时间、职业、地区分布、疫苗接种史、接触史、临床表现,并发症及治疗转归等临床资料.结果 本组成人麻疹患者以发热、咳嗽、流涕、皮疹为主要临床表现,52%有麻疹接触史,96%麻疹病毒抗体阳性,90%肝功能异常.治疗以抗病毒和保肝对症治疗为主.并发症以肝损害、电解质紊乱多见,少数并发支气管炎、心肌炎.结论 近年成人麻疹病例呈增多趋势,且成人麻疹病情复杂,病程长,全身中毒症状重,易于并发肝损害,早期积极治疗是关键,预后良好.%Objective To analyze and summarize the clinical features of adult measles and accumulate experience for clinical work. Methods The clinical data of onset tune, occupation, geographical distribution, vaccination history, exposure history, clinical manifestations, complications and treatment outcome were retrospectively analyzed in 225 patients with adult measles in our hospital from Jan. 2007 to Jan. 2011. Results The main symptoms with adult measles patients were fever, cough, runny nose, and rash. 52% of the patients had a history of exposure to measles, 96% with measles virus-IgM positive, and 90% with liver dysfunction. Antiviral and symptomatic therapy was the main treatment strategy for measles. Complications such as liver damage, electrolyte disorders were more common, and a small number of patients were with bronchitis and myocarditis. Conclusion Adult measles cases showed an increasing trend in recent years, and complex condition, longer duration, heavy symptoms of systemic poisoning and easy to concurrent liver damage occurred. Early and active treatment is the key to a good prognosis.

  12. Boronated monoclonal antibody 225. 28S for potential use in neutron capture therapy of malignant melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Tamat, S.R.; Moore, D.E.; Patwardhan, A.; Hersey, P. (Univ. of Sydney (Australia))

    1989-07-01

    The concept of conjugating boron cluster compounds to monoclonal antibodies has been examined by several groups of research workers in boron neutron capture therapy (BNCT). The procedures reported to date for boronation of monoclonal antibodies resulted in either an inadequate level of boron incorporation, the precipitation of the conjugates, or a loss of immunological activity. The present report describes the conjugation of dicesium-mercapto-undecahydrododecaborate (Cs2B12H11SH) to 225.28S monoclonal antibody directed against high molecular weight melanoma-associated antigens (HMW-MAA), using poly-L-ornithine as a bridge to increase the carrying capacity of the antibody and to minimize change in the conformational structure of antibody. The method produces a boron content of 1,300 to 1,700 B atoms per molecule 225.28S while retaining the immunoreactivity. Characterization in terms of the homogeneity of the conjugation of the boron-monoclonal antibody conjugates has been studied by gel electrophoresis and ion-exchange HPLC.

  13. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    CERN Document Server

    Dubey, R; Jhingan, A; Kaur, Gurpreet; Mukul, Ish; Mohanto, G; Siwal, D; Saneesh, N; Banerjee, T; Thakur, Meenu; Mahajan, Ruchi; Kumar, N; Chatterjee, M B

    2015-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206, 208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224, 226Th and 228U around barrier energies. Enhancement in mass variance of 225, 227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224, 226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential energy surfaces at low excitation energ...

  14. Neutron-deuteron analyzing power data at En=22.5 MeV

    Science.gov (United States)

    Weisel, G. J.; Tornow, W.; Crowell, A. S.; Esterline, J. H.; Hale, G. M.; Howell, C. R.; O'Malley, P. D.; Tompkins, J. R.; Witała, H.

    2014-05-01

    We present measurements of n-d analyzing power, Ay(θ), at En=22.5 MeV. The experiment uses a shielded neutron source which produced polarized neutrons via the 2H(d⃗,n⃗)3He reaction. It also uses a deuterated liquid-scintillator center detector and six pairs of liquid-scintillator neutron side detectors. Elastic neutron scattering events are identified by using time-of-flight techniques and by setting a window in the center detector pulse-height spectrum. The beam polarization is monitored by using a high-pressure helium gas cell and an additional pair of liquid-scintillator side detectors. The n-d Ay(θ) data were corrected for finite-geometry and multiple-scattering effects using a Monte Carlo simulation of the experiment. The 22.5-MeV data demonstrate that the three-nucleon analyzing power puzzle also exists at this energy. They show a significant discrepancy with predictions of high-precision nucleon-nucleon potentials alone or combined with Tucscon-Melbourne or Urbana IX three-nucleon forces, as well as currently available effective-field theory based potentials of next-to-next-to-next-to-leading order.

  15. Upgrades for an improved measurement of the EDM of 225Ra

    Science.gov (United States)

    Rabga, Tenzin; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Korsch, Wolfgang; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Tom P.; Fromm, Steven; Ready, Roy; Singh, Jaideep T.

    2017-01-01

    If charge conjugation (C), parity (P) and time-reversal (T) symmetries, collectively form a good symmetry of nature, CPT, then T-violating phenomena would also violate CP. An Electric Dipole Moment (EDM) would violate time-reversal symmetry, and therefor EDMs provide a sensitive way for probing CP-violation that might explain the abundance of matter over anti-matter in the Universe. The 225Ra atom (t1/2 = 15 days, I = 1/2) is a particularly attractive candidate for an EDM search in diamagnetic atoms due to its octupole deformed nuclear structure, nearly degenerate parity doublet ground state, and a large mass, that make it sensitive to T-violating interactions in the nuclear sector. Our latest measurement limits the atomic EDM of 225Ra to be less than 1.4x10-23 e-cm (95% C.L). Further experimental upgrades are being implemented including an electric field upgrade to enhance the EDM sensitivity and STIRAP for an improved spin precession detection scheme. With these upgrades in place our EDM sensitivity should increase by nearly two orders of magnitude and allow us to substantially improve constraints on certain T-violating processes within the nucleus. This work is supported by the U.S. DOE, Office of Science, Office of Nuclear Physics, under contract DE-AC02-06CH11357 and the Michigan State University.

  16. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer.

    Science.gov (United States)

    Herbst, Roy S; Hong, Waun Ki

    2002-10-01

    Squamous cell carcinoma of the head and neck remains a clinical challenge because of the high rate of locoregional disease recurrence. The importance of the epidermal growth factor receptor (EGFR) in the development and progression of many solid tumors, including squamous cell carcinoma of the head and neck, is well understood; increased expression is associated with enhanced tumor invasiveness, resistance to chemotherapy, and a lower patient survival rate. Several approaches have been developed to achieve EGFR blockade as an anticancer treatment strategy, including the anti-EGFR monoclonal antibody IMC-C225, which competitively binds to the extracellular receptor site and prevents binding by the natural EGFR ligands EGF and transforming growth factor-alpha. Preclinical studies to evaluate IMC-225 in human cancer cell lines in vitro and human tumor xenografts in vivo have shown its potent antitumor activity. Clinical efficacy of IMC-C225 appears to involve multiple mechanisms, including inhibition of cell cycle progression, induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, and enhancement of the response to chemotherapy and radiation therapy. Phase I studies of IMC-C225 combined with chemotherapy or radiation showed promising response rates in patients with recurrent or refractory squamous cell carcinoma of the head and neck. Phase II and III trials to examine the efficacy and safety of these combinations are currently underway. To date, IMC-C225 has been well tolerated, with skin rashes and allergic reactions being the most clinically important adverse events reported. IMC-C225 displays dose-dependent elimination characteristics and a half-life of approximately 7 days. Current recommendations for dosing include a 400 mg/m(2) loading dose, followed by weekly infusions at 250 mg/m(2).

  17. Reflection-asymmetric structures in 225Ra from γ-ray spectroscopy study of 229Th α decay

    Science.gov (United States)

    Gasparro, J.; Ardisson, G.; Barci, V.; Sheline, R. K.

    2000-12-01

    The level structure of 225Ra, produced in α decay of 229Th, was studied by γ-ray spectroscopy. The sources were continuously purified from daughters with ion-exchange chromatographic separation methods. Energies and intensities of 174 γ rays were accurately measured with HPGe detectors. About 100 γ rays were reported for the first time, especially in the 300-700 keV energy range. A 225Ra level scheme was proposed, accounting for about 200 transitions among 45 excited states. The level structure was interpreted in the framework of reflection-asymmetric structures with parity doublet bands. The model was shown to be in satisfactory agreement with experimental data.

  18. 41 CFR 102-37.225 - What information or documentation must a SASP provide when requesting a surplus aircraft or vessel?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What information or documentation must a SASP provide when requesting a surplus aircraft or vessel? 102-37.225 Section 102-37.225 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION...

  19. 20 CFR 30.225 - What are the criteria for eligibility for benefits under Part B of EEOICPA for certain uranium...

    Science.gov (United States)

    2010-04-01

    ... benefits under Part B of EEOICPA for certain uranium employees? 30.225 Section 30.225 Employees' Benefits... COMPENSATION PROGRAM ACT OF 2000, AS AMENDED Eligibility Criteria Eligibility Criteria for Certain Uranium... of EEOICPA for certain uranium employees? In order to be eligible for benefits under this...

  20. 48 CFR 52.225-21 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Science.gov (United States)

    2010-10-01

    ... Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-21 Section 52.225... of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following clause: Required Use of American Iron, Steel, and...

  1. 42 CFR 435.225 - Individuals under age 19 who would be eligible for Medicaid if they were in a medical institution.

    Science.gov (United States)

    2010-10-01

    ... Medicaid if they were in a medical institution. 435.225 Section 435.225 Public Health CENTERS FOR MEDICARE... age 19 who would be eligible for Medicaid if they were in a medical institution. (a) The agency may... would be eligible for Medicaid if they were in a medical institution, and who are receiving,...

  2. Evaluation of HCFC AK 225 Alternatives for Precision Cleaning and Verification

    Science.gov (United States)

    Melton, D. M.

    1998-01-01

    Maintaining qualified cleaning and verification processes are essential in an production environment. Environmental regulations have and are continuing to impact cleaning and verification processing in component and large structures, both at the Michoud Assembly Facility and component suppliers. The goal of the effort was to assure that the cleaning and verification proceeds unimpeded and that qualified, environmentally compliant material and process replacements are implemented and perform to specifications. The approach consisted of (1) selection of a Supersonic Gas-Liquid Cleaning System; (2) selection and evaluation of three cleaning and verification solvents as candidate alternatives to HCFC 225 (Vertrel 423 (HCFC), Vertrel MCA (HFC/1,2-Dichloroethylene), and HFE 7100DE (HFE/1,2 Dichloroethylene)); and evaluation of an analytical instrumental post cleaning verification technique. This document is presented in viewgraph format.

  3. Laser-trapping of Ra-225 and Ra-226 with repumping by room temperature blackbody radiation

    CERN Document Server

    Guest, J R; Bailey, K; Greene, J P; Holt, R J; Lu, Z T; O'Connor, T P; Potterveld, D H; Scielzo, N D

    2007-01-01

    We have demonstrated Zeeman slowing and capture of neutral Ra-225 and Ra-226 atoms in a magneto-optical trap (MOT). The intercombination transition 1S0-3P1 is the only quasi-cycling transition in radium and was used for laser-cooling and trapping. Repumping along the 3D1-1P1 transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable 3P0 level. We measured the isotope shift and hyperfine splittings on the 3D1-1P1 transition with the laser-cooled atoms, and set a limit on the lifetime of the 3D1 level based on the measured blackbody repumping rate. Laser-cooled and trapped radium is an attractive system for studying fundamental symmetries.

  4. NASA Rocket Propulsion Test Replacement Effort for Oxygen System Cleaner - Hydrochlorofluorocarbon (HCFC) 225

    Science.gov (United States)

    DeWitt Burns, H.; Mitchell, Mark A.; Lowrey, Nikki M.; Farner, Bruce R.; Ross, H. Richard

    2014-01-01

    Gaseous and liquid oxygen are extremely reactive materials used in bipropellant propulsion systems. Both flight and ground oxygen systems require a high level of cleanliness to support engine performance, testing, and prevent mishaps. Solvents used to clean and verify the cleanliness of oxygen systems and supporting test hardware must be compatible with the system's materials of construction and effective at removing or reducing expected contaminants to an acceptable level. This paper will define the philosophy and test approach used for evaluating replacement solvents for the current Marshall Space Flight Center/Stennis Space Center baseline HCFC-225 material that will no longer be available for purchase after 2014. MSFC/SSC applications in cleaning / sampling oxygen propulsion components, support equipment, and test system were reviewed then candidate replacement cleaners and test methods selected. All of these factors as well as testing results will be discussed.

  5. Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization.

    Science.gov (United States)

    Pandya, Darpan N; Hantgan, Roy; Budzevich, Mikalai M; Kock, Nancy D; Morse, David L; Batista, Izadora; Mintz, Akiva; Li, King C; Wadas, Thaddeus J

    2016-01-01

    The theranostic potential of (225)Ac-based radiopharmaceuticals continues to increase as researchers seek innovative ways to harness the nuclear decay of this radioisotope for therapeutic and imaging applications. This communication describes the evaluation of (225)Ac-DOTA-c(RGDyK) in both biodistribution and Cerenkov luminescence imaging (CLI) studies. Initially, La-DOTA-c(RGDyK) was prepared as a non-radioactive surrogate to evaluate methodologies that would contribute to an optimized radiochemical synthetic strategy and estimate the radioactive conjugate's affinity for αvβ3, using surface plasmon resonance spectroscopy. Surface plasmon resonance spectroscopy studies revealed the IC50 and Ki of La-DOTA-c(RGDyK) to be 33 ± 13 nM and 26 ± 11 nM, respectively, and suggest that the complexation of the La(3+) ion to the conjugate did not significantly alter integrin binding. Furthermore, use of this surrogate allowed optimization of radiochemical synthesis strategies to prepare (225)Ac-DOTA-c(RGDyK) with high radiochemical purity and specific activity similar to other (225)Ac-based radiopharmaceuticals. This radiopharmaceutical was highly stable in vitro. In vivo biodistribution studies confirmed the radiotracer's ability to target αvβ3 integrin with specificity; specificity was detected in tumor-bearing animals using Cerenkov luminescence imaging. Furthermore, tumor growth control was achieved using non-toxic doses of the radiopharmaceutical in U87mg tumor-bearing nude mice. To our knowledge, this is the first report to describe the CLI of αvβ3 (+) tumors in live animals using the daughter products derived from (225)Ac decay in situ. This concept holds promise to further enhance development of targeted alpha particle therapy.

  6. 40 CFR 1068.225 - What are the provisions for exempting engines/equipment for national security?

    Science.gov (United States)

    2010-07-01

    ... PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS GENERAL COMPLIANCE PROVISIONS FOR ENGINE PROGRAMS... following items: (1) The label heading “EMISSION CONTROL INFORMATION”. (2) Your corporate name and trademark... ENGINE HAS AN EXEMPTION FOR NATIONAL SECURITY UNDER 40 CFR 1068.225.” (ii) “THIS EQUIPMENT HAS...

  7. 76 FR 70531 - Fifth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

    Science.gov (United States)

    2011-11-14

    ... Federal Aviation Administration Fifth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S.... Working Group Meeting--Review draft document. Working Group report, review progress and actions....

  8. 77 FR 56253 - Ninth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

    Science.gov (United States)

    2012-09-12

    ... Federal Aviation Administration Ninth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S.... Working Group Meeting--Review draft document. Working Group report, review progress and actions....

  9. 12 CFR Appendix D to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Tier 1 Leverage Measure

    Science.gov (United States)

    2010-01-01

    ... above the minimum levels. Moreover, higher capital ratios may be required for any bank holding company... Companies: Tier 1 Leverage Measure D Appendix D to Part 225 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  10. 21 CFR 2.25 - Grain seed treated with poisonous substances; color identification to prevent adulteration of...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Grain seed treated with poisonous substances... RULINGS AND DECISIONS Human and Animal Foods § 2.25 Grain seed treated with poisonous substances; color... increasing use of poisonous treatments on seed for fungicidal and other purposes. Such treated seed,...

  11. 48 CFR 225.401-71 - Products or services in support of operations in Iraq or Afghanistan.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Products or services in... FOREIGN ACQUISITION Trade Agreements 225.401-71 Products or services in support of operations in Iraq or Afghanistan. When acquiring products or services, other than small arms, in support of operations in Iraq...

  12. 48 CFR 225.7303-2 - Cost of doing business with a foreign government or an international organization.

    Science.gov (United States)

    2010-10-01

    ... limited by FAR Part 31), such as— (i) Maintaining international sales and service organizations; (ii) Sales commissions and fees in accordance with FAR Subpart 3.4; (iii) Sales promotions, demonstrations... PROGRAMS FOREIGN ACQUISITION Acquisitions for Foreign Military Sales 225.7303-2 Cost of doing business...

  13. The Plant-Derived Chalcone 2,2',5'-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia.

    Science.gov (United States)

    Jiwrajka, Manasi; Phillips, Alexandra; Butler, Matt; Rossi, Miriam; Pocock, Jennifer M

    2016-01-01

    Chalcones are plant metabolites with potential for therapeutic exploitation as antioxidant, anti-inflammatory, and antiproliferative agents. Here we explored the neuroprotective effects of 2,2',5'-trihydroxychalcone (225THC), a potent antioxidant with radical-scavenging properties. 225THC was found to be a potent inhibitor of apoptosis in stimulated primary rat neuronal cultures. This was likely mediated by an anti-inflammatory effect on microglial cells since 225THC inhibited LPS-stimulated TNF-α and IL-6 secretion from primary rat microglia and modulated the cytokine/chemokine profile of BV2 microglial cells. Additionally, 225THC inhibited LPS-evoked inducible nitric oxide synthase expression but did not influence endogenous superoxide generation. Microglial flow cytometric analyses indicated the 225THC treatment induced a shift from an M1-like phenotype to a more downregulated microglial profile. Taken together these data suggest that the chalcone 2,2',5'-trihydroxychalcone can modulate neuroinflammatory activation in brain-derived microglia and holds promise as a therapeutic in neuroinflammatory conditions.

  14. Efficacy of the National Football League-225 Test to Track Changes in One Repetition Maximum Bench Press After Training in National Collegiate Athletic Association Division IA Football Players.

    Science.gov (United States)

    Mann, J Bryan; Ivey, Pat A; Stoner, Josh D; Mayhew, Jerry L; Brechue, William F

    2015-11-01

    Numerous investigations have attested to the efficacy of the National Football League (NFL)-225 test to estimate one repetition maximum (1RM) bench press. However, no studies have assessed the efficacy of the test to track changes in strength across a training program. The purpose of this study was to determine the accuracy of the NFL-225 test for determining the change in 1RM bench press in National Collegiate Athletic Association Division IA college football players after training. Over a 4-year period, players (n = 203) were assessed before and after a 6-week off-season resistance program for 1RM bench press and repetitions completed with 102.3 kg (225 lbs). Test sessions typically occurred within 1 week of each other. Players significantly increased 1RM by 4.2 ± 8.6 kg and NFL-225 repetitions by 0.9 ± 2.3, although the effect size (ES) for each was trivial (ES = 0.03 and 0.07, respectively). National Football League 225 prediction equations had higher correlations with 1RM before training (intraclass correlation coefficient [ICC] = 0.95) than after training (ICC = 0.75). The correlation between the change in NFL-225 repetitions and change in 1RM was low and negative (r = -0.22, p football players and render the NFL-225 test less effective in predicting the change in 1RM bench press strength after short-term training.

  15. 3.5 Year Monitoring of 225 GHz Opacity at the Summit of Greenland

    Science.gov (United States)

    Matsushita, Satoki; Asada, Keiichi; Martin-Cocher, Pierre L.; Chen, Ming-Tang; Ho, Paul T. P.; Inoue, Makoto; Koch, Patrick M.; Paine, Scott N.; Turner, David D.

    2017-02-01

    We present the 3.5 years monitoring results of 225 GHz opacity at the summit of the Greenland ice sheet (Greenland Summit Camp) at an altitude of 3200 m using a tipping radiometer. We chose this site as our submillimeter telescope (Greenland Telescope) site, because conditions are expected to have low submillimeter opacity and because its location offers favorable baselines to existing submillimeter telescopes for global-scale Very Long Baseline Interferometry. The site shows a clear seasonal variation with the average opacity lower by a factor of two during winter. The 25%, 50%, and 75% quartiles of the 225 GHz opacity during the winter months of November through April are 0.046, 0.060, and 0.080, respectively. For the winter quartiles of 25% and 50%, the Greenland site is about 10%-30% worse than the Atacama Large Millimeter/submillimeter Array (ALMA) or the South Pole sites. Estimated atmospheric transmission spectra in winter season are similar to the ALMA site at lower frequencies (\\lt 450 GHz), which are transparent enough to perform astronomical observations almost all of the winter time with opacities \\lt 0.5, but 10%-25% higher opacities at higher frequencies (\\gt 450 GHz) than those at the ALMA site. This is due to the lower altitude of the Greenland site and the resulting higher line wing opacity from pressure-broadened saturated water lines in addition to higher dry air continuum absorption at higher frequencies. Nevertheless, half of the winter time at the Greenland Summit Camp can be used for astronomical observations at frequencies between 450 GHz and 1000 GHz with opacities \\lt 1.2, and 10% of the time show \\gt 10 % transmittance in the THz (1035 GHz, 1350 GHz, and 1500 GHz) windows. Summer season is good for observations at frequencies lower than 380 GHz. One major advantage of the Greenland Summit Camp site in winter is that there is no diurnal variation due to the polar night condition, and therefore the durations of low-opacity conditions

  16. Isolation of Actinium from Neutron-irradiated Thorium-I

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Isolation of Actinium from Neutron-irradiated Thorium-I¥YangWeifan;YuanShuanggui;MuWantong;ZhangXueqian;LiZhongweiandZhaoLili...

  17. Blockage Testing in the NASA Glenn 225 Square Centimeter Supersonic Wind Tunnel

    Science.gov (United States)

    Sevier, Abigail; Davis, David; Schoenenberger, Mark

    2017-01-01

    A feasibility study is in progress at NASA Glenn Research Center to implement a magnetic suspension and balance system in the 225 sq cm Supersonic Wind Tunnel for the purpose of testing the dynamic stability of blunt bodies. An important area of investigation in this study was determining the optimum size of the model and the iron spherical core inside of it. In order to minimize the required magnetic field and thus the size of the magnetic suspension system, it was determined that the test model should be as large as possible. Blockage tests were conducted to determine the largest possible model that would allow for tunnel start at Mach 2, 2.5, and 3. Three different forebody model geometries were tested at different Mach numbers, axial locations in the tunnel, and in both a square and axisymmetric test section. Experimental results showed that different model geometries produced more varied results at higher Mach Numbers. It was also shown that testing closer to the nozzle allowed larger models to start compared with testing near the end of the test section. Finally, allowable model blockage was larger in the axisymmetric test section compared with the square test section at the same Mach number. This testing answered key questions posed by the feasibility study and will be used in the future to dictate model size and performance required from the magnetic suspension system.

  18. 3.5-Year Monitoring of 225 GHz Opacity at the Summit of Greenland

    CERN Document Server

    Matsushita, Satoki; Martin-Cocher, Pierre L; Chen, Ming-Tang; Ho, Paul T P; Inoue, Makoto; Koch, Patrick M; Paine, Scott N; Turner, David D

    2016-01-01

    We present the 3.5-yr monitoring results of 225 GHz opacity at the summit of the Greenland ice sheet (Greenland Summit Camp) at an altitude of 3200 m using a tipping radiometer. We chose this site as our submillimeter telescope (Greenland Telescope; GLT) site, because its location offers favorable baselines to existing submillimeter telescopes for global-scale VLBI. The site shows a clear seasonal variation with the average opacity lower by a factor of two during winter. For the winter quartiles of 25% and 50%, the Greenland site is about 10%-30% worse than the ALMA or the South Pole sites. Estimated atmospheric transmission spectra in winter season are similar to the ALMA site at lower frequencies (450 GHz) than those at the ALMA site. This is due to the lower altitude of the Greenland site. Nevertheless, half of the winter time at the Greenland site can be used for astronomical observations at frequencies between 450 GHz and 1000 GHz with opacities 10% transmittance in the THz (1035 GHz, 1350 GHz, and 1500 ...

  19. The natural course of non-classic Pompe's disease; a review of 225 published cases.

    Science.gov (United States)

    Winkel, Léon P F; Hagemans, Marloes L C; van Doorn, Pieter A; Loonen, M Christa B; Hop, Wim J C; Reuser, Arnold J J; van der Ploeg, Ans T

    2005-08-01

    Pompe's disease is a neuromuscular disorder caused by deficiency of lysosomal acid alpha-glucosidase. Recombinant human alpha- glucosidase is under evaluation as therapeutic drug. In light of this development we studied the natural course of cases not fitting the definition of classic infantile Pompe's disease. Our review of 109 reports including 225 cases shows a continuous spectrum of phenotypes. The onset of symptoms ranged from 0 to 71 years. Based on the available literature, no criteria to delineate clinical sub-types could be established.A common denominator of these cases is that first symptoms were related to or caused by muscle weakness. In general, patients with a later onset of symptoms seemed to have a better prognosis. Respiratory failure was the most frequent cause of death. CK, LDH, ASAT, ALAT and muscle glycogen levels were frequently but not always elevated. In most cases a muscle biopsy revealed lysosomal pathology, but normal muscle morphology does not exclude Pompe's disease. In 10% of the cases in which the enzyme assay on leukocytes was used, a normal alpha-glucosidase activity was reported. Data on skeletal muscle strength and function, pulmonary function, disability, handicap and quality of life were insufficiently reported in the literature. Studies of non-classic Pompe's disease should focus on these aspects, before enzyme replacement therapy becomes generally available.

  20. Magnetically Dominated Parallel Interstellar Filaments at the Infrared Dark Cloud G14.225-0.506

    CERN Document Server

    Santos, Fabio P; Franco, Gabriel A P; Girart, Josep M; Zhang, Qizhou

    2016-01-01

    The G14.225-0.506 infrared dark cloud (IRDC G14.2) displays a remarkable complex of parallel dense molecular filaments projected on the plane of the sky. Previous dust emission and molecular-line studies have speculated whether magnetic fields could have played an important role in the formation of such long-shaped structures, which are hosts to numerous young stellar sources. In this work we have conducted a vast polarimetric survey at optical and near-infrared wavelengths in order to study the morphology of magnetic field lines in IRDC G14.2 through the observation of background stars. The orientation of interstellar polarization, which traces magnetic field lines, is perpendicular to most of the filamentary features within the cloud. Additionally, the larger-scale molecular cloud as a whole exhibits an elongated shape also perpendicular to magnetic fields. Estimates of magnetic field strengths indicate values in the range $320 - 550\\,\\mu$G, which allows sub-alfv\\'enic conditions, but does not prevent the g...

  1. Electric dipole moment of $^{225}$Ra due to P- and T-violating weak interactions

    CERN Document Server

    Singh, Yashpal

    2015-01-01

    We report rigorous calculations of electric dipole moment (EDM) in $^{225}$Ra due to parity and time-reversal violating tensor-pseudotensor (T-PT) and nuclear Schiff moment (NSM) interactions between the electrons and nucleus by employing the relativistic all order coupled-cluster (RCC) methods at various levels of approximation. The most accurate EDM ($d_A$) results are obtained as $d_A=-10.04\\times 10^{-20} C_T |e|cm$ and $d_A^{NSM}=-6.79 \\times 10^{-17} S (|e|fm^3)^{-1} |e|cm$ with $C_T$ and $S$ are the T-PT coupling constant and NSM respectively. Due to exhaustive treatment of the electron correlation effects in these calculations, the EDM results for the corresponding T-PT and NSM interactions reduce by about 45\\% and 23\\%, respectively, from the previously known values. Nonetheless they are still found to be 2-3 times larger than the $^{199}$Hg results. Validity of the RCC results are countenanced by comparing our calculations at the zeroth order Dirac-Fock method and all order random-phase approximatio...

  2. Underwater Laser-illuminated Range-gated Imaging Scaled by 22.5 cm ns-1 with Serial Targets

    Institute of Scientific and Technical Information of China (English)

    HE Duo-Min

    2004-01-01

    We have developed a novel target set to scale our Underwater Laser-illuminated Range-gated Imaging(ULRI)video system in a 3 m-tank with turbid water(attenuation coefficient 1.0 m-1). As light speed in water is 22.5 cm ns-1, the target set consists of a series of 3-bar targets at 22.5 cm intervals along the laser illumination direction, with the targets separated vertically. As a result, a sequence of good gated images, in steps of 1 ns delay, is presented, which is a revelation of the' sliced-view' phenomenon for ns-level range-gating in such a limited water body. The Depth of Gating(DOG)and DOG-profile of the URLI system are measured for the first time, which can be used for evaluating gating-performance efficiently.

  3. KINETICS OF TEMPER EMBRITTLEMENT IN 2.25Cr-1Mo STEEL USED FOR HOT-WALL HYDROFINING REACTORS

    Institute of Scientific and Technical Information of China (English)

    J.Z.Tan

    2004-01-01

    Based on the theory of grain boundary segregation,a kinetics model of temper embrittlement caused by long-term service for hot-wall hydrofining reactors was studied.The kinetics model was applied to phosphorus(P)segregation in 2.25Cr-1Mo steel used for a hot-wall hydrofining reactor,and the kinetics of grain boundary segregation of impurity P in the steel exposed to the process environment of the hydrofining reactor was calculated on the basis of the model.The Auger electron spectroscopy test was performed in order to determine the grain boundary concentration of P.The experimental result is agreement with the theoretical calculated data.The results show that the kinetics equation is reasonable for predicting the levels of grain boundary segregation of impurity P in 2.25Cr-1Mo steel used for hot-wall hydrofining reactors.

  4. Performance characteristics of automotive engines in the United States: Report No. 9, Chrysler (1975) 225-CID 1-bbl engine

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, W.F.; Stamper, K.R.

    1977-08-01

    Experimental data were obtained in dynamometer tests of a 1975 Chrysler 225-CID, 1-bbl engine to determine fuel consumption and emissions (hydrocarbon, carbon monoxide, and oxides of nitrogen) at steady-state engine operating modes. The objective of the program is to obtain engine performance data for estimating emissions and fuel economy for varied engine service and duty. The intent of the work is to provide basic engine characteristic data required as input for engineering calculations involving ground transportation.

  5. Chondroitin sulfate proteoglycan-4 (CSPG4)-specific monoclonal antibody 225.28 in detection of acute myeloid leukemia blasts.

    Science.gov (United States)

    Fenton, Moon; Whiteside, Theresa L; Ferrone, Soldano; Boyiadzis, Michael

    2015-01-01

    Chondroitin sulfate proteoglycan-4 (CSPG4), a membrane-bound proteoglycan known to be expressed on the surface of malignant cells, has a restricted distribution in normal tissues. CSPG4 is a potential candidate tumor marker. We investigate CSPG4 expression on blasts in newly diagnosed acute myeloid leukemia (AML) patients and its relation with cytogenetic abnormalities and molecular markers known to have prognostic significance in this disease. Using hybridoma technology, we generated a specific monoclonal antibody (mAb), mAb 225.28, reactive with CSPG4. Blast samples obtained from the peripheral blood of newly diagnosed AML patients were analyzed for CSPG4 expression using the CSPG4-specific mAb and multiparameter flow cytometry. The results were correlated with cytogenetic and molecular characteristics of AML. CSPG4 was found to be expressed on a variable fraction of leukemic blasts in all AML patients with different leukemia morphology, including monoblastic cases. Reactivity of CSPG4-specific mAb with leukemic blasts was not limited to those with the rearranged MLL gene. CSPG4 was also expressed on AML blasts with a complex karyotype, FLT3 mutation, or NPM1 mutation. The results indicate that CSPG4 is expressed and detectable by flow cytometry using the mAb 225.28 on a proportion of blasts of all subtypes of AML irrespective of cytogenetic and molecular abnormalities. mAb 225.28 could be useful in detecting AML blasts by flow cytometry.

  6. Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2)

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Randall C.; Hughes, Ronny C.; Flatt, Justin W.; Meehan, Edward J.; Ng, Joseph D.; Twigg, Pamela D.; (UAH)

    2009-08-07

    The ubiquitin-conjugating enzyme E2-25K has been identified as a huntingtin (the key protein in Huntington's disease) interacting protein and has been shown to play a role in mediating the toxicity of A{beta}, the principal protein involved in Alzheimer's disease pathogenesis. E2-25K is a dual-domain protein with an ubiquitin-associated (UBA) domain as well as a conserved ubiquitin-conjugating (UBC) domain which catalyzes the formation of a covalent bond between the C-terminal glycine of an ubiquitin molecule and the {var_epsilon}-amine of a lysine residue on the acceptor protein as part of the ubiquitin-proteasome pathway. The crystal structures of E2-25K M172A mutant protein at pH 6.5 and pH 8.5 were determined to 1.9 and 2.2 {angstrom} resolution, respectively. Examination of the structures revealed domain-domain interactions between the UBC and UBA domains which have not previously been reported

  7. Replacement of Hydrochlorofluorocarbon (HCFC) -225 Solvent for Cleaning and Verification Sampling of NASA Propulsion Oxygen Systems Hardware, Ground Support Equipment, and Associated Test Systems

    Science.gov (United States)

    Burns, H. D.; Mitchell, M. A.; McMillian, J. H.; Farner, B. R.; Harper, S. A.; Peralta, S. F.; Lowrey, N. M.; Ross, H. R.; Juarez, A.

    2015-01-01

    Since the 1990's, NASA's rocket propulsion test facilities at Marshall Space Flight Center (MSFC) and Stennis Space Center (SSC) have used hydrochlorofluorocarbon-225 (HCFC-225), a Class II ozone-depleting substance, to safety clean and verify the cleanliness of large scale propulsion oxygen systems and associated test facilities. In 2012 through 2014, test laboratories at MSFC, SSC, and Johnson Space Center-White Sands Test Facility collaborated to seek out, test, and qualify an environmentally preferred replacement for HCFC-225. Candidate solvents were selected, a test plan was developed, and the products were tested for materials compatibility, oxygen compatibility, cleaning effectiveness, and suitability for use in cleanliness verification and field cleaning operations. Honewell Soltice (TradeMark) Performance Fluid (trans-1-chloro-3,3, 3-trifluoropropene) was selected to replace HCFC-225 at NASA's MSFC and SSC rocket propulsion test facilities.

  8. Water availability and vulnerability of 225 large cities in the United States

    Science.gov (United States)

    Padowski, Julie C.; Jawitz, James W.

    2012-12-01

    This study presents a quantitative national assessment of urban water availability and vulnerability for 225 U.S. cities with population greater than 100,000. Here, the urban assessments account for not only renewable water flows, but also the extracted, imported, and stored water that urban systems access through constructed infrastructure. These sources represent important hydraulic components of the urban water supply, yet are typically excluded from water scarcity assessments. Results from this hydraulic-based assessment were compared to those obtained using a more conventional method that estimates scarcity solely based on local renewable flows. The inclusion of hydraulic components increased the mean availability to cities, leading to a significantly lower portion of the total U.S. population considered "at risk" for water scarcity (17%) than that obtained from the runoff method (47%). Water vulnerability was determined based on low-flow conditions, and smaller differences were found for this metric between at-risk populations using the runoff (66%) and hydraulic-based (54%) methods. The large increase in the susceptible population between the scarcity measures evaluated using the hydraulic method may better reconcile the seeming contradiction in the United States between perceptions of natural water abundance and widespread water scarcity. Additionally, urban vulnerability measures developed here were validated using a media text analysis. Vulnerability assessments that included hydraulic components were found to correlate with the frequency of urban water scarcity reports in the popular press while runoff-based measures showed no significant correlation, suggesting that hydraulic-based assessments provide better context for understanding the nature and severity of urban water scarcity issues.

  9. Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.

    Science.gov (United States)

    Kamiński, Krzysztof; Rapacz, Anna; Łuszczki, Jarogniew J; Latacz, Gniewomir; Obniska, Jolanta; Kieć-Kononowicz, Katarzyna; Filipek, Barbara

    2015-05-15

    The purpose of this study was to synthesize the library of 33 new N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamides, 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)propanamides, and 2-(2,5-dioxopyrrolidin-1-yl)butanamides as potential new hybrid anticonvulsant agents. These hybrid molecules join the chemical fragments of well-known antiepileptic drugs (AEDs) such as ethosuximide, levetiracetam, and lacosamide. The coupling reaction of the 2-(2,5-dioxopyrrolidin-1-yl)propanoic acid, 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)propanoic acid, or 2-(2,5-dioxopyrrolidin-1-yl)butanoic acid with the appropriately substituted benzylamines in the presence of the coupling reagent, N,N-carbonyldiimidazole (CDI) generated the final compounds 4-36. Spectral data acquired via (1)H NMR, (13)C NMR, and LC-MS confirmed the chemical structures of the newly prepared compounds. The initial anticonvulsant screening was performed in mice intraperitoneally (ip), using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure tests. The rotarod test determined the acute neurological toxicity (NT). The results of preliminary pharmacological screening revealed that 25 compounds showed protection in half or more of the animals tested in the MES and/or scPTZ seizure models at the fixed dose of 100mg/kg. The broad spectra of activity across the preclinical seizure models displayed compounds 4, 7, 8, 13, 15-18, 24, and 26. The quantitative pharmacological studies in mice demonstrated the highest protection for compounds 4 (ED50 MES=67.65 mg/kg, ED50scPTZ=42.83 mg/kg); 8 (ED50 MES=54.90 mg/kg, ED50scPTZ=50.29 mg/kg); and 20 (ED50scPTZ=47.39 mg/kg). These compounds were distinctly more potent and provided better safety profiles in the rotarod test compared to valproic acid or ethosuximide, which were used as model AEDs. Compound 8 underwent only a slight metabolic change by the human liver microsomes (HLMs), and also did not affect the activity of human cytochrome P450 isoform

  10. 2007年度ENR全球最大225强国际承包商排名出炉

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    2007年8月16日,美国麦格劳·希尔公司(Mc—Graw—Hill)发布了2007年度ENR全球最大225强国际承包商排名。我国内地共有49家企业榜上有名。排名基本参照数据为企业上一年度即2006年度对外承包工程完成营业额。

  11. Volatility-constrained correlation identifies the directionality of the influence between Japan’s Nikkei 225 and other financial markets

    Science.gov (United States)

    Ochiai, Tomoshiro; Nacher, Jose C.

    2014-01-01

    Recent financial crises have shown the importance of determining the directionality of the influence between financial assets in order to identify the origin of market instabilities. Here, we analyze the correlation between Japan’s Nikkei stock average index (Nikkei 225) and other financial markets by introducing a volatility-constrained correlation metric. The asymmetric feature of the metric reveals which asset is more influential than the other. As a result, this method allows us to unveil the directionality of the correlation effect, which could not be observed from the standard correlation analysis. Furthermore, we present a theoretical model that reproduces the results observed in empirical analysis.

  12. Therapeutic efficacy and toxicity of {sup 225}Ac-labelled vs. {sup 213}Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Essler, Markus; Gaertner, Florian C.; Blechert, Birgit; Senekowitsch-Schmidtke, Reingard; Seidl, Christof [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Neff, Frauke [Helmholtz Zentrum Muenchen, Institute of Pathology, Neuherberg (Germany); Bruchertseifer, Frank; Morgenstern, Alfred [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany)

    2012-04-15

    Targeted delivery of alpha-particle-emitting radionuclides is a promising novel option in cancer therapy. We generated stable conjugates of the vascular tumour-homing peptide F3 both with {sup 225}Ac and {sup 213}Bi that specifically bind to nucleolin on the surface of proliferating tumour cells. The aim of our study was to determine the therapeutic efficacy of {sup 225}Ac-DOTA-F3 in comparison with that of {sup 213}Bi-DTPA-F3. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were determined via clonogenic assays. The therapeutic efficacy of both constructs was assayed by repeated treatment of mice bearing intraperitoneal MDA-MB-435 xenograft tumours. Therapy was monitored by bioluminescence imaging. Nephrotoxic effects were analysed by histology. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were 53 kBq/ml and 67 Bq/ml, respectively. The median survival of control mice treated with phosphate-buffered saline was 60 days after intraperitoneal inoculation of 1 x 10{sup 7} MDA-MB-435 cells. Therapy with 6 x 1.85 kBq of {sup 225}Ac-DOTA-F3 or 6 x 1.85 MBq of {sup 213}Bi-DTPA-F3 prolonged median survival to 95 days and 97 days, respectively. While F3 labelled with short-lived {sup 213}Bi (t{sub 1/2} 46 min) reduced the tumour mass at early time-points up to 30 days after treatment, the antitumour effect of {sup 225}Ac-DOTA-F3 (t{sub 1/2} 10 days) increased at later time-points. The difference in the fraction of necrotic cells after treatment with {sup 225}Ac-DOTA-F3 (43%) and with {sup 213}Bi-DTPA-F3 (36%) was not significant. Though histological analysis of kidney samples revealed acute tubular necrosis and tubular oedema in 10-30% of animals after treatment with {sup 225}Ac-DOTA-F3 or {sup 213}Bi-DTPA-F3, protein casts were negligible (2%), indicating only minor damage to the kidney. Therapy with both {sup 225}Ac-DOTA-F3 and {sup 213}Bi-DTPA-F3 increased survival of mice with peritoneal carcinomatosis. Mild renal toxicity of both

  13. Development of Cr{sub 3}C{sub 2}-25(Ni20Cr) nanostructured coatings; Desenvolvimento de revestimentos nanostruturados de Cr{sub 3}C{sub 2}-25(Ni20Cr)

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Cecilio Alvares da

    2012-07-01

    This study is divided in two parts. The first part is about the preparation of nanostructured Cr{sub 3}C{sub 2}-25(Ni20Cr) powders by high energy milling followed by characterization of the milled and the as received powder. Analyses of some of the data obtained were done using a theoretical approach. The second part of this study is about the preparation and characterization of coatings prepared with the nanostructured as well as the as received Cr{sub 3}C{sub 2}-25(Ni20Cr) powders. The high temperature erosion-oxidation (E-O) behavior of the coatings prepared with the two types of powders has been compared based on a technological approach. The average crystallite size of the Cr{sub 3}C{sub 2}-25(Ni20Cr) powder decreased rapidly from 145 nm to 50 nm in the initial stages of milling and thereafter decreased slowly to a steady state value of around 10 nm with further increase in milling time. This steady state corresponds to the beginning of a dynamic recovery process. The maximum lattice strain ({epsilon} = 1,17%) was observed in powders milled for 16 hours, and this powders critical crystallite size was 28 nm. In contrast, the lattice parameter attained a minimum for powders milled for 16 hours. Upon reaching the critical crystallite size, the dislocation density attained a steady state regime and all plastic deformation introduced in the material there after was in the form of events occurring at the grain boundaries, due mainly to grain boundary sliding. The deformation energy stored in the crystal lattice of the Cr{sub 3}C{sub 2}-25(Ni20Cr) powders milled for different times was determined from enthalpy variation measurements. These results indicated that the maximum enthalpy variation ({delta}H = 722 mcal) also occurred for powders milled for 16 hours. In a similar manner, the maximum specific heat variation ({delta}C{sub p} = 0,278 cal/gK) occurred for powders milled for 16 hours. The following mechanical properties of Cr{sub 3}C{sub 2}-25(Ni20Cr) coatings

  14. Aγ-225~-222缺失复合β地中海贫血的研究%RESEARCH ON THE Aγ-225 TO-222 DELETION IN COMPOUND WITH β-THALASSEMIA

    Institute of Scientific and Technical Information of China (English)

    朱恒莹; 陈萍; 林伟雄; 李树全; 肖璇; 谢湘芝; 杨德寨

    2015-01-01

    目的:探讨A γ-225~-222缺失导致的非缺失型遗传性持续性胎儿血红蛋白综合征(nondeletional hereditary persistence of fetal hemoglobin,nd HPFH)复合β地中海贫血的基因突变和临床特征.方法:选择2013年6月至2014年7月在广西医科大学第一附属医院就诊的病例进行血常规检查;应用高效液相色谱法(HPLC)测定血红蛋白Hb F和Hb A2水平;应用DNA测序方法分析γ珠蛋白基因突变;应用反向斑点杂交(RDB)和gap-PCR方法检测地中海贫血基因突变;应用SPSS 16.0统计软件对数据进行统计分析.结果:在122例Hb F增高的病例中,检测出7例Aγ-225~222 AGCA缺失杂合子,其中3例复合Gγ-158 C→T突变杂合子,1例同时复合β地中海贫血28 A→G突变杂合子以及Gγ-158 C→T突变杂合子,1例复合β地中海贫血CD17 A →T突变杂合子.血常规检查显示7例Hb为96.7~142.3 g/L,MCV为54.61~77.65 fl,MCH为16.10~25.26 pg.Hb分析显示7例Hb F为4.0%~11.2%,其中复合Gγ-158 C→T突变杂合子HbF为4.0%~8.1%,复合β地中海贫血杂合子Hb F为8.1%~11.2%.5例Hb A2正常,2例复合β地中海贫血杂合子Hb A2增高(5.6%~6.4%).Aγ225~-222缺失复合β地中海贫血杂合子与β地中海贫血杂合子相比,Hb F、Hb水平明显升高(P<0.05).结论:Aγ 225~222缺失可导致Hb F水平升高,其杂合子均无临床症状,Hb正常或降低,MCV、MCH降低.Aγ-225~-222缺失复合β地中海贫血杂合子的HbF、Hb水平明显高于β地中海贫血杂合子.

  15. First-principles study of the electronic structure of a superstoichiometric rare earth dihydride GdH2.25

    Institute of Scientific and Technical Information of China (English)

    Z. Ayat; A. Boukraa; B. Daoudi

    2016-01-01

    We performedab initio calculations of electronic structure and equilibrium properties for the rare earth superstoichiometric dihydride GdH2.25 (with the space groupPm-3m (No. 221)) using the full-potential linearized augmented plane wave method (FP-LAPW) approach within the density functional theory (DFT) in the generalized gradient approximation (GGA) and local density approximation (LDA) as implemented in the WIEN2k simulation code at 0 K. The equilibrium properties were determined, the den-sity of states, electronic density and the energy band structures were studied in details. It was concluded that the GGA optimized lat-tice parameter agreed much better with the experimental findings than the LDA one. The non negligible electronic density of states at the Fermi level confirmed that the GdH2.25 had a metallic character. The Fermi energyEF fell at a level where most of the states were rare-earth 5d-eg conduction states while negligible contributions of both interstitial (tetrahedral and octahedral) H s-states were ob-served nearEF. From electronic density, the bonding between Gd and tetrahedral H atoms was of prominent covalency, while was ionic between Gd and octahedral H atoms.

  16. Research of stress corrosion cracking of T225NG titanium alloy in loop water of high temperature and high pressure

    Institute of Scientific and Technical Information of China (English)

    Xu Jijin; Yan Keng; Chen Ligong; Jiang Chengyu

    2006-01-01

    Double cantilever beam (DCB) specimens were used to research the stress corrosion cracking of T225NG titanium alloy in loop water of high temperature and high pressure. DCB specimens were forced pre-stress, put into high pressure autoclave, and the stress corrosion and crack expansion of specimens were observed and measured in 500 h, 1 000 h and 2 000h respectively. The results show that small expansion occurred along the direction of pre-cracking. According to calculation,the speed of cracking expansion is lower than 10 -9 m/s in 500 h and the value of KIscc/KI is higher than 0. 75, which proves that T225NG has an excellent corrosion resistance in loop water. The main reason is that there is an oxide film on the surface of specimens. According to the analysis of energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD), the oxide film consists of TiO2. Therefore, the oxide film at the crack tip impedes the hydrogen separating out from the cathode to penetrate into titanium alloy and resists hydrogen embrittlement.

  17. Targeted Alpha Therapy: The US DOE Tri-Lab (ORNL, BNL, LANL) Research Effort to Provide Accelerator-Produced 225Ac for Radiotherapy

    Science.gov (United States)

    John, Kevin

    2017-01-01

    Targeted radiotherapy is an emerging discipline of cancer therapy that exploits the biochemical differences between normal cells and cancer cells to selectively deliver a lethal dose of radiation to cancer cells, while leaving healthy cells relatively unperturbed. A broad overview of targeted alpha therapy including isotope production methods, and associated isotope production facility needs, will be provided. A more general overview of the US Department of Energy Isotope Program's Tri-Lab (ORNL, BNL, LANL) Research Effort to Provide Accelerator-Produced 225Ac for Radiotherapy will also be presented focusing on the accelerator-production of 225Ac and final product isolation methodologies for medical applications.

  18. Epidermal growth factor receptors as a target for cancer treatment: the emerging role of IMC-C225 in the treatment of lung and head and neck cancers.

    Science.gov (United States)

    Herbst, Roy S; Langer, Corey J

    2002-02-01

    Epidermal growth factor receptor is one of four receptors critical to cellular proliferation, differentiation, and survival, and is widely expressed in malignant tissue, particularly in squamous cell carcinoma of the head and neck. Expression has been associated with malignant progression, inhibition of apoptosis, neoplastic angiogenesis, enhanced metastatic potential, and both chemoresistance and radioresistance. IMC-C225 is a chimeric monoclonal antibody that targets extracellular epidermal growth factor receptor; it has shown both in vitro and in vivo antitumor activity in tumor cells lines expressing epidermal growth factor receptor, including heightened radiation response in vitro in cultured human squamous cell carcinoma and enhancement of taxane- and platinum-induced cytotoxicity in non-small cell lung cancer xenografts. In A431 head and neck squamous cell xenografts, IMC-C225 administered both before and after radiation therapy yields a radiation enhancement factor of 3.62, attributable to both tumor necrosis and antiangiogenesis. In phase I pharmacokinetic studies, IMC-C225 has a long half-life, lending itself to convenient weekly administration. It has shown a favorable toxicity profile, limited primarily to allergic and dermatologic reactions, the latter characterized by a self-limited, sterile, acneiform rash. Anaphylaxis is rare. Standard treatment entails a loading dose of 400 mg/m(2) at week 1, followed by a maintenance dose of 250 mg/m(2) weekly. An ongoing phase III international multicenter, randomized study in locally advanced squamous cell carcinoma of the head and neck is evaluating therapeutic radiation therapy, either alone or in conjunction with IMC-C225. In a pilot trial, six of nine patients with platinum-exposed squamous cell carcinoma of the head and neck exhibited objective response. In an ongoing phase II trial in patients with stable or progressive disease on platinum-based therapy, the preliminary response rate is approximately 20

  19. Influence of epidermal growth factor receptor monoclony antibody MAb225 on DNA repair of tongue carcinoma cell after radiation%表皮生长因子受体单抗MAb225对舌癌细胞DNA放射后损伤修复的影响

    Institute of Scientific and Technical Information of China (English)

    王明国; 王中和

    2011-01-01

    Objective The objective of this study is to investigate the effect of epidermal growth factor receptor (EGFR) monoclonal antibody MAb225 on repair of DNA double strand break (DNA-DSB) after radiation in tongue squamous cell carcinoma cell. Methods The single cell gel electrophoresis(SCGE) was performed to estimate the repair of DNA-DSB induced by radiation in human tongue carcinoma cells Tca8113 treated with or without MAb225. Expression of Ku70 and Ku80 were detected by semiquantitative reverse transcription polymerase chain reaction and Western bolt Results Comet tail moment of MAb225 treated cell was significantly higher than untreated cell(P<0.05). The expression of Ku70 and Ku80 were inhibited by MAb225. Conclusion MAb225 can inhibit repair of DNA-DSB induced by down-regulated expression of Ku70 and Ku80.%目的 研究表皮生长因子受体(EGFR)单克隆抗体MAb225对放射所致舌癌细胞DNA损伤修复的影响及其作用机制.方法 应用单细胞凝胶电泳的方法检测MAb225对舌鳞癌细胞Tca8113放射后DNA双链断裂所致的尾矩,半定量逆转录多聚酶链反应和Western blot检测MAb225对DNA蛋白激酶Ku70、Ku80表达的影响.结果 MAb225作用后的细胞单细胞凝胶电泳的彗星尾矩明显高于未处理细胞(P<0.05),并能显著抑制DNA蛋白激酶Ku70、Ku80的表达.结论 MAb225通过抑制DNA蛋白激酶Ku70、Ku80的表达影响了DNA双链断裂的修复能力.

  20. Cyclic and isothermal oxidation behavior of 2.25Cr-1Mo steel; Estudio del comportamiento del acero 2.25Cr-1Mo frente a los fenomenos de oxidacion ciclica e isoterma

    Energy Technology Data Exchange (ETDEWEB)

    Proy, M.; Utrilla, M. v.; Otero, E.

    2014-04-01

    Cyclic and isothermal oxidation of chromium-molybdenum steel 2.25Cr-1Mo were analyzed at 550 degree centigrade and 650 degree centigrade during 360 hours in air atmospheres. The cycles were performed with two stages; one of heating in furnace during 90 minutes and then the sample were cooled to 50 degree centigrade by air flow. Thermogravimetric analyses were performed to obtain high temperature corrosion kinetics. Several characterization techniques have been used to identify the corrosion mechanism, as X-Ray Diffraction (XRD), Optical Microscopy (OM) and Scanning Electron Microscopy (SEM). Thermal cycling tests can changes the corrosion mechanism, due cracks propagation in oxide scale, that witch can favors the access of oxidant agent to the substrate. (Author)

  1. 全国225家实验室 D-二聚体决定限的调查与分析%National wide survey and analysis on decision limits of D-Dimer in 225 laboratories

    Institute of Scientific and Technical Information of China (English)

    何法霖; 王薇; 钟堃; 张妍; 赵彦; 李国华; 王治国

    2015-01-01

    Objective To calculate and describe the decision limits of 2014 external quality assessment(EQA) programs in D-Dimer of 225 labs.Methods To collectedthe information of decision limits which come from the 2014 External Quality Assessment ( EQA) programs in D-Dimer.All data from maternal and child care service centers , children′s hospitals and corporations were excluded .Then all the abnormal values and errors were eliminated either .Data of 225 labs statistics were processed by Microsoft Excel 2007, which include the mean, median, maximum value, minimum value, P2.5 and P97.5.Weanalyzed the sources of decision limits and then get the data filtered .The reagent manufacturer 's instructions data are reservedas a reference source and data are analyzed according to differentreagents .Results According to the surveys of decision limits sources ,most of thereference sources use the reagent manufacturer′s instructions. According to the surveys,the mean and median of each test project is close .The P2.5 and P97.5 distribution ranges are: D-Dimer(DDU) 0.3 -1.33 μg/ml,D-Dimer(FEU) 0.23 -1.50 μg/ml,with significant differences.According to the surveys , most P2.5 and P97.5 reagent distributions are significantly different . Conclusion The decision limitsof the mean and median of each test item are approximate ,and the P2.5 and P97.5 distributions of each test item are poorly consistent .%目的:统计并描述2014年全国225家回报D-二聚体决定限。方法选择卫生部临床检验中心2014年全国D-二聚体室间质量评价回报结果中参评单位的决定限信息,剔除所有妇幼保健院、儿童医院和各类公司的结果,再剔除所有异常值和错误数据,使用Microsoft Excel 2007对225家实验室进行统计分析,包括平均值、中位数、最小值、最大值、P2.5和P97.5。统计决定限来源,同时对数据进行筛选,保留决定限来源于试剂厂家说明书的数据,

  2. Curative effect observation on 225 case of self-simulation Chaihushuganlidan therapeutic treatment on cholecystitis%自拟柴胡疏肝利胆汤治疗胆囊炎225例疗效观察

    Institute of Scientific and Technical Information of China (English)

    张成军; 朱琳; 刘玉芳

    2012-01-01

    目的观察柴胡疏肝利胆汤治疗胆囊炎的疗效.方法将符合条件的450例患者随机分为治疗组和对照组各225例,治疗组服用柴胡疏肝利胆汤,对照组采用西医常规治疗,两组均治疗3个疗程(7天为1个疗程)后观察疗效.结果两组患者均获不同程度的疗效,但治疗组的疗效明显优于对照组(P<0.05),差异有统计学意义.结论柴胡疏肝利胆汤具有疏肝利胆、行气止痛、化湿清热、利胆排石的功效,且无副作用,便于推广.%Purpose: observation the curative effect of Chaihushuganlidan therapeutic treatment on cholecystitis. Method: random distribution 450 standard patients into two groups with respectively with 225 cases as curative group and control group. The curative group is offered with chaihushudanlidan therapeutic, while the control group is offered with western medical curative treatment. Those two groups both have three courses of treatment (one course of treatment has seven days), then the observation could begin. Result: both two groups of patients get the curative effect with different extent, however, the curative effect of curative group is better than that of control group(p<0.05), that difference has significance of statistics. Conclusion: Chaihushuganlidan therapeutic has the effect of shuganlidan, work qi and remove the pain, disappear the dampness and hotness, benefit the gallbladder and remove the gallstone, with no side effect and convenient to expand.

  3. An FEGSTEM Study of Grain Boundary Segregation of Phosphorus during Quenching in a 2.25Cr-1Mo Steel

    Institute of Scientific and Technical Information of China (English)

    Shenhua SONG; Luqian WENG

    2005-01-01

    Quenching-induced phosphorus segregation to prior austenite grain boundaries in a 0.077 wt pct P-doped 2.25Cr1Mo steel is examined using field emission gun scanning transmission electron microscopy (FEGSTEM). A phosphorus level of around 1.56 at. pct is observed for the water-quenched sample. In recognition of insufficiently high spatial resolution of the technique for grain boundary composition analysis, the measured results are corrected by an analytical convolution method. The corrected phosphorus segregation level may be up to about 4.7 at. pct. The quenchinginduced phosphorus segregation is nonequilibrium segregation and the migration of vacancy-phosphorus complexes plays an important role in the kinetic process. For such a reason, the mechanism for migration of the complexes is discussed in some detail.

  4. Reporting the first 3 years of 225-GHz opacity measurements at the site of the Large Millimeter Telescope Alfonso Serrano

    Science.gov (United States)

    Zeballos, M.; Ferrusca, D.; Contreras R., J.; Hughes, D. H.

    2016-07-01

    The Large Millimeter Telescope Alfonso Serrano (LMT) is located in Puebla, Mexico, at an altitude of 4580 m. It is currently the largest single-dish telescope constructed to observe the Universe at wavelengths between 0.85 and 4 mm. Identifying interstellar molecules, exploring dense dark clouds, and understanding the properties of cold matter and interstellar dust in the local and distant Universe are among its main scientific goals. Since June 2013, the LMT has conducted four shared-risk early science campaigns* observing at 1.1 mm (AzTEC), and 3 mm (RSR) with the aid of a new meteorological and radiometer system to guide the flexibility scheduling of observing time. Here we report measurements of the atmospheric opacity taken with this radiometer at 225 GHz between June 2013 and April 2016. These measurements show that the LMT site has exceptional weather conditions with opacities season, making it a very convenient site for sub-millimeter/millimeter astronomy.

  5. ZASNOVA IN RAČUNSKA ANALIZA DVONADSTROPNE INDUSTRIJSKE JEKLENE HALE TLORISA 22,5 M X 60 M

    OpenAIRE

    Šenveter, Primož

    2013-01-01

    Namen diplomskega dela je izvedba zasnove in računske analize dvonadstropne industrijske jeklene hale. Hala je zasnovana v tlorisni obliki črke L, dimenzij 12,5 x 40 m za večji vzdolžni del hale ter 22,5 x 20 m za manjši del hale. Na manjšem delu hale je tudi nadstropje, kjer se nahajajo prostori za »režijo«. Uporabili smo vroče valjane profile iz konstrukcijskega jekla S 355. Izbrali smo profile s čim večjo izkoriščenostjo prereza, saj bo le tako poraba jeklenega materiala za celoten objekt ...

  6. A short gamma-ray burst apparently associated with an elliptical galaxy at redshift z = 0.225.

    Science.gov (United States)

    Gehrels, N; Sarazin, C L; O'Brien, P T; Zhang, B; Barbier, L; Barthelmy, S D; Blustin, A; Burrows, D N; Cannizzo, J; Cummings, J R; Goad, M; Holland, S T; Hurkett, C P; Kennea, J A; Levan, A; Markwardt, C B; Mason, K O; Meszaros, P; Page, M; Palmer, D M; Rol, E; Sakamoto, T; Willingale, R; Angelini, L; Beardmore, A; Boyd, P T; Breeveld, A; Campana, S; Chester, M M; Chincarini, G; Cominsky, L R; Cusumano, G; de Pasquale, M; Fenimore, E E; Giommi, P; Gronwall, C; Grupe, D; Hill, J E; Hinshaw, D; Hjorth, J; Hullinger, D; Hurley, K C; Klose, S; Kobayashi, S; Kouveliotou, C; Krimm, H A; Mangano, V; Marshall, F E; McGowan, K; Moretti, A; Mushotzky, R F; Nakazawa, K; Norris, J P; Nousek, J A; Osborne, J P; Page, K; Parsons, A M; Patel, S; Perri, M; Poole, T; Romano, P; Roming, P W A; Rosen, S; Sato, G; Schady, P; Smale, A P; Sollerman, J; Starling, R; Still, M; Suzuki, M; Tagliaferri, G; Takahashi, T; Tashiro, M; Tueller, J; Wells, A A; White, N E; Wijers, R A M J

    2005-10-06

    Gamma-ray bursts (GRBs) come in two classes: long (> 2 s), soft-spectrum bursts and short, hard events. Most progress has been made on understanding the long GRBs, which are typically observed at high redshift (z approximately 1) and found in subluminous star-forming host galaxies. They are likely to be produced in core-collapse explosions of massive stars. In contrast, no short GRB had been accurately (sky is near a luminous, non-star-forming elliptical galaxy at a redshift of 0.225, which is the location one would expect if the origin of this GRB is through the merger of neutron-star or black-hole binaries. The X-ray afterglow was weak and faded below the detection limit within a few hours; no optical afterglow was detected to stringent limits, explaining the past difficulty in localizing short GRBs.

  7. UNVEILING A NETWORK OF PARALLEL FILAMENTS IN THE INFRARED DARK CLOUD G14.225-0.506

    Energy Technology Data Exchange (ETDEWEB)

    Busquet, Gemma [INAF-Istituto di Astrofisica e Planetologia Spaziali, via Fosso del Cavaliere 100, I-00133 Roma (Italy); Zhang, Qizhou; Ho, Paul T. P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Palau, Aina; Girart, Josep M. [Institut de Ciencies de l' Espai (CSIC-IEEC), Campus UAB, Facultat de Ciencies, Torre C-5 parell, E-08193 Bellaterra, Catalunya (Spain); Liu, Hauyu Baobab [Academia Sinica Institute of Astronomy and Astrophysics, Taipei, Taiwan (China); Sanchez-Monge, Alvaro [INAF, Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-05125 Firenze (Italy); Estalella, Robert [Departament d' Astronomia i Meteorologia, Institut de Ciencies del Cosmos (ICC), Universitat de Barcelona (IEEC-UB), Marti i Franques 1, E-08028 Barcelona, Catalunya (Spain); De Gregorio-Monsalvo, Itziar [European Southern Observatory, Karl-Schwarzschild-Strasse 2, D-85748 Garching (Germany); Pillai, Thushara [Caltech Astronomy Department, MC 249-17, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Wyrowski, Friedrich [Max-Planck-Institut fuer Radioastronomie, Auf dem Huegel 69, D-53121 Bonn (Germany); Santos, Fabio P.; Franco, Gabriel A. P., E-mail: gemma.busquet@iaps.inaf.it [Departamento de Fisica-ICEx-UFMG, Caixa Postal 702, 30.123-970 Belo Horizonte-MG (Brazil)

    2013-02-20

    We present the results of combined NH{sub 3} (1,1) and (2,2) line emission observed with the Very Large Array and the Effelsberg 100 m telescope of the infrared dark cloud G14.225-0.506. The NH{sub 3} emission reveals a network of filaments constituting two hub-filament systems. Hubs are associated with gas of rotational temperature T{sub rot} {approx} 15 K, non-thermal velocity dispersion {sigma}{sub NT} {approx} 1 km s{sup -1}, and exhibit signs of star formation, while filaments appear to be more quiescent (T{sub rot} {approx} 11 K and {sigma}{sub NT} {approx} 0.6 km s{sup -1}). Filaments are parallel in projection and distributed mainly along two directions, at P.A. {approx} 10 Degree-Sign and 60 Degree-Sign , and appear to be coherent in velocity. The averaged projected separation between adjacent filaments is between 0.5 pc and 1 pc, and the mean width of filaments is 0.12 pc. Cores within filaments are separated by {approx}0.33 {+-} 0.09 pc, which is consistent with the predicted fragmentation of an isothermal gas cylinder due to the {sup s}ausage{sup -}type instability. The network of parallel filaments observed in G14.225-0.506 is consistent with the gravitational instability of a thin gas layer threaded by magnetic fields. Overall, our data suggest that magnetic fields might play an important role in the alignment of filaments, and polarization measurements in the entire cloud would lend further support to this scenario.

  8. Evaluation of Ceria-Added Cr3C2-25(NiCr) Coating on Three Superalloys under Simulated Incinerator Environment

    Science.gov (United States)

    Mudgal, Deepa; Singh, Surendra; Prakash, Satya

    2015-02-01

    Cr3C2-25(NiCr) coating is widely used in wear, erosion and corrosion applications. In the present study, D-gun-sprayed Cr3C2-25(NiCr) coatings with and without 0.4 wt.% ceria incorporated were deposited on Superni 718, Superni 600 and Superco 605 substrates. Hot-corrosion runs were conducted in 40 %Na2SO4-40 %K2SO4-10 %NaCl-10 %KCl environment at 900 °C for 100 cycles. Corrosion kinetics was monitored using weight gain measurements. Characterization of corrosion products was carried out by field-emission scanning electron microscopy (FESEM)/energy-dispersive spectroscopy (EDS) and x-ray diffraction (XRD) techniques. It was observed that Cr3C2-25(NiCr) coating with and without added ceria deposited on both of the Ni-based alloys showed resistance to corrosion under the given environment. Addition of ceria enhanced the adherence of the oxide to the coating during the corrosion run and reduced the overall weight gain. However, Cr3C2-25(NiCr)-coated Superco 605 did not perform satisfactorily under this environment.

  9. Prospective clinical phase II study of two new indwelling voice prostheses (Provox Vega 22.5 and 20 Fr) and a novel anterograde insertion device (Provox Smart Inserter)

    NARCIS (Netherlands)

    Hilgers, F.J.M.; Ackerstaff, A.H.; Jacobi, I.; Balm, A.J.M.; Tan, I.B.; van den Brekel, M.W.M.

    2010-01-01

    Objectives/Hypothesis: To assess device life of the new Provox Vega 22.5 and 20 Fr prostheses, to establish whether the optimized airflow characteristics of these devices materialize in better voice characteristics in comparison to Provox2, and to assess the feasibility of voice prosthesis replaceme

  10. 48 CFR 52.225-24 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Science.gov (United States)

    2010-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials Under Trade Agreements....225-24 Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act...: Notice of Required Use of American Iron, Steel, and Manufactured Goods—Buy American...

  11. 48 CFR 52.225-22 - Notice of Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act...

    Science.gov (United States)

    2010-10-01

    ... American Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials. 52.225-22 Section 52... Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials. As prescribed in 25.1102(e), insert the following provision: Notice of Required Use of American Iron, Steel,...

  12. 48 CFR 52.225-23 - Required Use of American Iron, Steel, and Manufactured Goods-Buy American Act-Construction...

    Science.gov (United States)

    2010-10-01

    ... Iron, Steel, and Manufactured Goods-Buy American Act-Construction Materials Under Trade Agreements. 52....225-23 Required Use of American Iron, Steel, and Manufactured Goods—Buy American Act—Construction... American Iron, Steel, and Manufactured Goods—Buy American Act—Construction Materials Under Trade...

  13. 20 CFR 645.225 - How do Welfare-to-Work activities relate to activities provided through TANF and other related...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How do Welfare-to-Work activities relate to... EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING WELFARE-TO-WORK GRANTS General Program and Administrative Requirements § 645.225 How do Welfare-to-Work activities relate...

  14. [Detection of leptospira by culture of vitreous humor and detection of antibodies against leptospira in vitreous humor and serum of 225 horses with equine recurrent uveitis].

    Science.gov (United States)

    Dorrego-Keiter, Elisa; Tóth, József; Dikker, Lieke; Sielhorst, Jutta; Schusser, Gerald Fritz

    2016-01-01

    In the ongoing discussion regarding the aetiopathogenesis of equine recurrent uveitis (ERU) it was the aim of the present study to elucidate the relationship of leptospira infection and ERU. In a population of 225 horses leptospira were examined in vitreous humor by culture and leptospira antibody were detected in vitreous humor and serum samples. Preoperative serum samples were collected from 221/225 ERU patients of different age, gender and breed. Undiluted vitreous humor was aseptically taken from 198/225 patients that underwent pars plana vitrectomy at the beginning of surgery and from 27/225 patients' eyeball after enucleation: Serum and vitreous humor were tested for specific leptospiral antibodies by microscopic agglutination test (MAT). Furthermore, vitreous humor was examined by culture. 20 patients which were euthanized due to a live-threatening disease other than ERU served as a control group. A total of 127/221 (57.5%) horses had serum antibodies (≥ 1:100). Most frequently antibodies against L. interrogans serovar Grippotyphosa were detected (79/127), followed by L. interrogans serovar lcterohaemorrhagiae (34/127) and L. interrogans serovar Bratislava (29/127). Only 79/225 horses (35.1%) had leptospiral antibodies in vitreous humor, in which L. interrogans serovar Grippotyphosa (67/79) was identified most frequently followed by L. interrogans serovar Pomona (18/79) and L. interrogans serovar lcterohaemorrhagiae (8/79) which was identified as single or multiple reaction. Isolation of leptospira from vitreous humor was positive in 34/212 horses (16%). 10/20 control horses had a positive antibody titer against leptospira in serum and 2/20 horses in vitreous humor, whereas there was no leptospira detected in culture. The result of 84% negative cultures from vitreous humor of 212 ERU patients is decisive for the diagnosis and therapy of ERU.

  15. 225名育龄妇女孕前、孕中及产后微量元素调查%Survey on Microelements of Pre - pregnancy, Pregnancy and Postpartum Periods Among 225 Childbearing Age Women

    Institute of Scientific and Technical Information of China (English)

    王建辉

    2011-01-01

    Objective To investigate the levels and influencing factors of the microelements in pre- pregnancy, pregnancy, and postpartum periods among the childbearing age women, and to offer the scientific evidence for the health care of childbearing age women. Methods We collected the blood samples of 225 childbearing age women who received the examination during the pre- pregnancy, pregnancy, and postpartum periods in the Maternal and Child Health Hospital of Hunan Province from January 2009 to May 2011. Atomic absorption spectrometer was used to detect the contents of Ca, Mg, Fe, Zn, and Cu in serum. Results The levels of Ca, Mg, Fe, Zn, and Cu showed a skewed distribution in different periods. The deficiency of Fe was common in the pregnancy and postpartum periods (P<0.05); and moreover, the levels of Zn and Ca were generally lower in the pregnancy and postpartum periods (P<0.05). Conclusions The levels of the microelements in the pregnancy and postpartum periods are lower, which suggest that it has significance to the growth of fetus and the recovery of puerpera through scientific intake of the nutrition and necessary microelements according to the eating habits and strengthening the physical exercises.%目的 了解育龄妇女在孕前、孕中及产后微量元素水平变化及影响因素,为育龄妇女营养保健提供科学依据.方法 连续收集2009年1月- 2011年5月在本院孕前、孕中检查及产后体检的225例育龄妇女血样,用原子吸收光谱分析仪检测Ca、Mg、Fe、Zn、Cu的含量.结果 不同时期妇女全血中Ca、Mg、Fe、Zn、Cu含量呈偏态分布,孕期及产后铁缺乏常见(P<0.05).另外,孕期和产后妇女锌、钙也总体偏低(P<0.05).结论 孕期及产后妇女微量元素营养状况处在一个较低的水平,提示应注意合理营养摄人,根据饮食习惯科学补充必需的微量元素,适当加强锻炼,对体内胎儿发育及自身恢复都有一定的意义.

  16. Gain-of-function R225W mutation in human AMPKgamma(3 causing increased glycogen and decreased triglyceride in skeletal muscle.

    Directory of Open Access Journals (Sweden)

    Sheila R Costford

    Full Text Available BACKGROUND: AMP-activated protein kinase (AMPK is a heterotrimeric enzyme that is evolutionarily conserved from yeast to mammals and functions to maintain cellular and whole body energy homeostasis. Studies in experimental animals demonstrate that activation of AMPK in skeletal muscle protects against insulin resistance, type 2 diabetes and obesity. The regulatory gamma(3 subunit of AMPK is expressed exclusively in skeletal muscle; however, its importance in controlling overall AMPK activity is unknown. While evidence is emerging that gamma subunit mutations interfere specifically with AMP activation, there remains some controversy regarding the impact of gamma subunit mutations. Here we report the first gain-of-function mutation in the muscle-specific regulatory gamma(3 subunit in humans. METHODS AND FINDINGS: We sequenced the exons and splice junctions of the AMPK gamma(3 gene (PRKAG3 in 761 obese and 759 lean individuals, identifying 87 sequence variants including a novel R225W mutation in subjects from two unrelated families. The gamma(3 R225W mutation is homologous in location to the gamma(2R302Q mutation in patients with Wolf-Parkinson-White syndrome and to the gamma(3R225Q mutation originally linked to an increase in muscle glycogen content in purebred Hampshire Rendement Napole (RN- pigs. We demonstrate in differentiated muscle satellite cells obtained from the vastus lateralis of R225W carriers that the mutation is associated with an approximate doubling of both basal and AMP-activated AMPK activities. Moreover, subjects bearing the R225W mutation exhibit a approximately 90% increase of skeletal muscle glycogen content and a approximately 30% decrease in intramuscular triglyceride (IMTG. CONCLUSIONS: We have identified for the first time a mutation in the skeletal muscle-specific regulatory gamma(3 subunit of AMPK in humans. The gamma(3R225W mutation has significant functional effects as demonstrated by increases in basal and AMP

  17. Analysis of Clinical Features and Tinnitus Characteristics in 225 Patients with Auditory Neuropathy%225例听神经病患者的耳鸣发生特点及临床特征分析

    Institute of Scientific and Technical Information of China (English)

    齐悦; 王秋菊; 兰兰; 史伟; 张秋静; 纵亮; 张娇; 李娜; 王大勇; 李倩

    2013-01-01

      目的调查听神经病患者的耳鸣发生情况,并分析伴发耳鸣的听神经病患者的临床特征及听力学特点.方法对225例听神经病患者(均可准确陈述病史)进行病史采集及纯音测听、声导抗、听性脑干反应、DPOAE、言语识别率、耳蜗电图等听力学检测,并对结果总结分析.结果①225例听神经病患者就诊年龄3~45岁,男女比例1:1.23,发生耳鸣的患者126例,比例达56%,青少年期及青年期发病的患者耳鸣发生率最高,分别为63.03%(75/119)和66.67%(32/48);②男性和女性患者耳鸣发生率分别为52.48%和58.87%,差异无统计学意义;③耳鸣发生率随病程增长而增高,病程10年以上的听神经病患者耳鸣发生率高达82.14%(23/28);④综合征型听神经病患者耳鸣发生率明显高于非综合征性听神经病患者(84.00%>42.00%);⑤轻中度听力损失的听神经病患者耳鸣发生率明显高于其他听力损失类型.结论本组听神经病患者耳鸣发生与听神经病发病年龄、病程、听力损失程度及类型有一定相关性.听神经病患者耳鸣发生的临床特征分析对进一步探讨听神经病患者耳鸣发生机理提供临床资料.%Objective To investigate the occurrence of tinnitus in patients with auditory neuropathy and analyze their clinical and audiological characteristics. Methods Clinical history, physical examination and audiological examination data (including pure tone audiometry, acoustic impedance, ABRs, DPOAEs, speech perception and ECochG) were reviewed and analyzed in 225 patients with auditory neuropathy (age 3 to 45 years, male to female ratio=1:1.23 ). Results 1) Tinnitus was reported by 126 of the 225 AN patients (56%), more in adolescent patients. 2) Incidence of tinnitus in male and female patients was 52.48% and 58.87%, respectively, without significant difference (P>0.05). 3) The incidence of tinnitus in⁃creased as the duration of AN,increased and was as high

  18. Incommensurate stripe order in La2-xSrxNiO4 with x=0.225

    Science.gov (United States)

    Tranquada, J. M.; Buttrey, D. J.; Sachan, V.

    1996-11-01

    In recent studies of La2-xSrxNiO4 it has been suggested that ordering of the dopant-induced holes occurs only commensurately at special values of x, such as 1/3 and 1/2. Commensurate order of both charge and spin densities has also been found in a crystal with x=0.20. The present neutron scattering study of an x=0.225 crystal demonstrates that the spin and charge order can also be incommensurate. In fact, the incommensurability is temperature dependent, as observed previously in La2NiO4.125, indicating that such behavior is intrinsic to the doped NiO2 layers and not dependent on ordering of the dopant ions. A careful analysis of the unusual variation of peak widths as a function of momentum transfer perpendicular to the planes shows that the charge- and spin-density modulations are tied to the lattice, with the shift in phase of the charge modulations from one layer to the next equal to exactly one in-plane lattice spacing. A comparison of results for a number of samples shows that the charge and spin ordering temperatures vary linearly with hole concentration, with charge order always occurring at higher temperature, clearly indicating that the ordering is driven by the charge.

  19. Reduction of Intergranular Cracking Susceptibility by Precipitation Control in 2.25Cr Heat-Resistant Steels

    Science.gov (United States)

    Sung, Hyun Je; Heo, Nam Hoe; Kim, Sung-Joon

    2017-03-01

    This research is performed to decrease reheat cracking susceptibility in the T/P23 heat-resistant steels (2.25Cr1.5WVNbTi), in other words, to reduce phosphorus and sulfur segregation concentration at the prior austenite grain boundary/carbide interfaces (GCIs) and the carbide-free prior austenite grain boundaries (carbide-free PAGBs) causing intergranular cracking. The increase of bulk vanadium content reduces the amount of M23C6 carbides consuming carbon atoms which can repulse phosphorus and sulfur from interfaces, but promotes the precipitation reaction of V-rich MX carbo-nitrides. Such a precipitation reaction results in the lower segregation concentration of phosphorus or no sulfur at the GCIs and the carbide-free PAGBs. This is because the carbon atoms remaining after precipitation reaction segregates to the interfaces and repels phosphorus and sulfur. Also, tungsten segregation can increase the cohesive grain boundary strength as one of the grain boundary strengtheners. Consequently, the lower segregation concentration of the impurities and the segregation of tungsten atoms lower the intergranular cracking susceptibility.

  20. Reduction of Intergranular Cracking Susceptibility by Precipitation Control in 2.25Cr Heat-Resistant Steels

    Science.gov (United States)

    Sung, Hyun Je; Heo, Nam Hoe; Kim, Sung-Joon

    2017-01-01

    This research is performed to decrease reheat cracking susceptibility in the T/P23 heat-resistant steels (2.25Cr1.5WVNbTi), in other words, to reduce phosphorus and sulfur segregation concentration at the prior austenite grain boundary/carbide interfaces (GCIs) and the carbide-free prior austenite grain boundaries (carbide-free PAGBs) causing intergranular cracking. The increase of bulk vanadium content reduces the amount of M23C6 carbides consuming carbon atoms which can repulse phosphorus and sulfur from interfaces, but promotes the precipitation reaction of V-rich MX carbo-nitrides. Such a precipitation reaction results in the lower segregation concentration of phosphorus or no sulfur at the GCIs and the carbide-free PAGBs. This is because the carbon atoms remaining after precipitation reaction segregates to the interfaces and repels phosphorus and sulfur. Also, tungsten segregation can increase the cohesive grain boundary strength as one of the grain boundary strengtheners. Consequently, the lower segregation concentration of the impurities and the segregation of tungsten atoms lower the intergranular cracking susceptibility.

  1. Unveiling a network of parallel filaments in the Infrared Dark Cloud G14.225-0.506

    CERN Document Server

    Busquet, Gemma; Palau, Aina; Liu, Hauyu Baobab; Sánchez-Monge, Álvaro; Estalella, Robert; Ho, Paul T P; de Gregorio-Monsalvo, Itziar; Pillai, Thushara; Wyrowski, Friedrich; Girart, Josep M; Santos, Fábio P; Franco, Gabriel A P

    2012-01-01

    We present the results of combined NH3(1,1) and (2,2) line emission observed with the Very Large Array and the Effelsberg 100m telescope of the Infrared Dark Cloud G14.225-0.506. The NH3 emission reveals a network of filaments constituting two hub-filament systems. Hubs are associated with gas of rotational temperature Trot \\sim 25 K, non-thermal velocity dispersion ~1.1 km/s, and exhibit signs of star formation, while filaments appear to be more quiescent (Trot \\sim 11 K, non-thermal velocity dispersion ~0.6 km/s). Filaments are parallel in projection and distributed mainly along two directions, at PA \\sim 10 deg and 60 deg, and appear to be coherent in velocity. The averaged projected separation between adjacent filaments is between 0.5 pc and 1pc, and the mean width of filaments is 0.12 pc. Cores within filaments are separated by ~0.33 pc, which is consistent with the predicted fragmentation of an isothermal gas cylinder due to the 'sausage'-type instability. The network of parallel filaments observed in G...

  2. Long-Term Flux Monitoring of LSI +61 303 at 2.25 and 8.3 GHz

    CERN Document Server

    Ray, P; Waltman, E B; Tavani, M; Ghigo, F D

    1997-01-01

    LSI +61 303 is an exotic binary system consisting of a ~10 Msun B star and a compact object which is probably a neutron star. The system is associated with the interesting radio source GT0236+610 that exhibits bright radio outbursts with a period of 26.5 days. We report the results of continuous daily radio interferometric observations of GT0236+610 at 2.25 and 8.3 GHz from 1994 January to 1996 February. The observations cover 25 complete (and 3 partial) cycles with multiple observations each day. We detect substantial cycle-to-cycle variability of the radio emission characterized by a rapid onset of the radio flares followed by a more gradual decrease of the emission. We detect a systematic change of the radio spectral index alpha which typically becomes larger than zero at the onset of the radio outbursts. This behavior is suggestive of expansion of material initially optically thick to radio frequencies, indicating either that synchrotron or inverse Compton cooling are important or that the free-free optic...

  3. Dense core properties in the Infrared Dark cloud G14.225-0.506 revealed by ALMA

    CERN Document Server

    Ohashi, Satoshi; Chen, Huei-Ru Vivien; Zhang, Qizhou; Busquet, Gemma; Nakamura, Fumitaka; Palau, Aina; Tatematsu, Ken'ichi

    2016-01-01

    We have performed a dense core survey toward the Infrared Dark Cloud G14.225-0.506 at 3 mm continuum emission with the Atacama Large Millimeter/Submillimeter Array (ALMA). This survey covers the two hub-filament systems with an angular resolution of $\\sim3$\\arcsec ($\\sim0.03$ pc). We identified 48 dense cores. Twenty out of the 48 cores are protostellar due to their association with young stellar objects (YSOs) and/or X-ray point-sources, while the other 28 cores are likely prestellar and unrelated with known IR or X-ray emission. Using APEX 870 $\\mu$m continuum emission, we also identified the 18 clumps hosting these cores. Through virial analysis using the ALMA N$_2$H$^+$ and VLA/Effelsberg NH$_3$ molecular line data, we found a decreasing trend in the virial parameter with decreasing scales from filaments to clumps, and then to cores. The virial parameters of $0.1-1.3$ in cores, indicate that cores are likely undergoing dynamical collapse. The cumulative Core Mass Function (CMF) for the prestellar cores ca...

  4. Atomic Pair-Correlation Anisotropy Induced by Magnetic Annealing of Ferromagnetic Fe22.5Ni77.5 Permalloy

    Science.gov (United States)

    Sparks, Cullie; Robertson, Lee; Ice, Gene; Bai, Jianming

    2002-03-01

    Diffuse x-ray scattering measurements have been made on ferromagnetic Fe22.5Ni77.5, permalloy, annealed in a 3000 G magnetic field at 450° C. These measurements reveal a long predicted anisotropic alignment of the Fe-Ni, Fe-Fe and Ni-Ni near-neighbor pairs relative to the magnetic field direction when annealed at temperatures below the Curie Temperature but high enough for diffusion to occur. Our direct measurements show that the Fe-Fe and Ni-Ni first neighbor pairs preferentially align along the annealing direction of the magnetic field for fields in the [100], [110] and [111] crystallographic directions. Fe-Ni pairs prefer to align perpendicular to the direction of the applied field. The size of the observed anisotropy in the atom pair distribution follows that observed in their magnetic properties1; the anisotropy increases from [100] to [110] to [111]. This first direct verification that magnetic annealing preferentially aligns the direction of the atomic pairs will be discussed. 1. S. Chikazumi, J. Phys. Soc. Japan 11, 551 (1956).

  5. Uptake of /sup 99m/Tc labelled (Fab')/sub 2/ fragments of monoclonal antibody 225. 28S by a benign ocular naevus

    Energy Technology Data Exchange (ETDEWEB)

    Bomanji, J.; Granowska, M.; Britton, K.E.; Hungerford, J.L.

    1988-06-01

    Malignant melanoma is one of the most common primary intraocular neoplasms. Recently, /sup 99m/Tc radiolabelled (Fab')/sub 2/ fragments of monoclonal antibody 225.28S raised against cutaneous melanomas have been used for imaging uveal melanomas. We report here a case where uptake of radiolabelled antibody was observed in a choroidal melanoma of the right eye and a benign choroidal naevus of the left.

  6. High-Temperature Exposure Studies of HVOF-Sprayed Cr3C2-25(NiCr)/(WC-Co) Coating

    Science.gov (United States)

    Singh, Harpreet; Kaur, Manpreet; Prakash, Satya

    2016-08-01

    In this research, development of Cr3C2-25(NiCr) + 25%(WC-Co) composite coating was done and investigated. Cr3C2-25(NiCr) + 25%(WC-Co) composite powder [designated as HP2 powder] was prepared by mechanical mixing of [75Cr3C2-25(NiCr)] and [88WC-12Co] powders in the ratio of 75:25 by weight. The blended powders were used as feedstock to deposit composite coating on ASTM SA213-T22 substrate using High Velocity Oxy-Fuel (HVOF) spray process. High-temperature oxidation/corrosion behavior of the bare and coated boiler steels was investigated at 700 °C for 50 cycles in air, as well as, in Na2SO4-82%Fe2(SO4)3 molten salt environment in the laboratory. Erosion-corrosion behavior was investigated in the actual boiler environment at 700 ± 10 °C under cyclic conditions for 1500 h. The weight-change technique was used to establish the kinetics of oxidation/corrosion/erosion-corrosion. X-ray diffraction, field emission-scanning electron microscopy/energy-dispersive spectroscopy (FE-SEM/EDS), and EDS elemental mapping techniques were used to analyze the exposed samples. The uncoated boiler steel suffered from a catastrophic degradation in the form of intense spalling of the scale in all the environments. The oxidation/corrosion/erosion-corrosion resistance of the HVOF-sprayed HP2 coating was found to be better in comparison with standalone Cr3C2-25(NiCr) coating. A simultaneous formation of protective phases might have contributed the best properties to the coating.

  7. Crystallization in Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass under pressure

    DEFF Research Database (Denmark)

    Jiang, Jianzhong; Zhou, T.J.; Rasmussen, Helge Kildahl;

    2000-01-01

    The effect of pressure on the crystallization behavior of the bulk metallic glass-forming Zr41.2Ti13.8Cu12.5Ni10Be22.5 alloy with a wide supercooled liquid region has been investigated by in situ high-pressure and high-temperature x-ray powder diffraction measurements using synchrotron radiation....... In the pressure range from 0 to 3 GPa, the crystallization temperature increases with pressure having a slope of 19 K/GPa, which can be explained by the suppression of atomic mobility. This observation is opposite to the results of W.H. Wang, D.W. He, D.Q. Zhao, and Y.S. Yao [Appl. Phys. Lett. 75, 2770 (1999......)], reporting a decrease of the crystallization temperature under pressure in a pressure range of 0-6 GPa for the bulk glass Zr41Ti14Cu12.5Ni9Be22.5C1 alloy. Compressibility with a volume reduction of approximately 22% at room temperature does not induce crystallization in the Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk...

  8. Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-kappaB signaling pathway with the anti-epidermal growth factor antibody IMC-C225.

    Science.gov (United States)

    Sclabas, Guido M; Fujioka, Shuichi; Schmidt, Christian; Fan, Zhen; Evans, Douglas B; Chiao, Paul J

    2003-01-01

    We have previously demonstrated that RelA is constitutively activated in the majority of human pancreatic cancers and plays an important role in tumorigenesis and metastasis. The antiapoptotic gene bcl-xl is a downstream target of RelA, and regulation of bcl-xl transcription is mediated directly by the nuclear factor kappaB (NF-kappaB) binding sites present in the upstream promoter element of the bcl-xl gene. In this study we investigated the effects of inhibition of epidermal growth factor receptor (EGFR) signaling pathway with the anti-EGFR monoclonal antibody IMC-C225 on constitutive NF-kappaB activation and regulation of apoptosis-related genes in human pancreatic cancer cells. We found that activation of EGFR can be blocked with the anti-EGFR antibody IMC-C225 in the human pancreatic cancer cell line MDA Panc-28, leading to a marked decrease in constitutive NF-kappaB DNA binding activity. Our data also suggest that downregulation of NF-kappaB DNA binding activity by IMC-C225 leads to a decrease in bcl-xl and bfl-1 expression. Therefore, targeting the NF-kappaB signaling pathway with an anti-EGFR antibody may be one strategy to restore apoptosis in human pancreatic cancer cells, thereby enhancing the effect of chemotherapy and radiation therapy.

  9. Field Test Report: Preliminary Aquifer Test Characterization Results for Well 299-W15-225: Supporting Phase I of the 200-ZP-1 Groundwater Operable Unit Remedial Design

    Energy Technology Data Exchange (ETDEWEB)

    Spane, Frank A.; Newcomer, Darrell R.

    2009-09-23

    This report examines the hydrologic test results for both local vertical profile characterization and large-scale hydrologic tests associated with a new extraction well (well 299-W15-225) that was constructed during FY2009 for inclusion within the future 200-West Area Groundwater Treatment System that is scheduled to go on-line at the end of FY2011. To facilitate the analysis of the large-scale hydrologic test performed at newly constructed extraction well 299-W15-225 (C7017; also referred to as EW-1 in some planning documents), the existing 200-ZP-1 interim pump-and-treat system was completely shut-down ~1 month before the performance of the large-scale hydrologic test. Specifically, this report 1) applies recently developed methods for removing barometric pressure fluctuations from well water-level measurements to enhance the detection of hydrologic test and pump-and-treat system effects at selected monitor wells, 2) analyzes the barometric-corrected well water-level responses for a preliminary determination of large-scale hydraulic properties, and 3) provides an assessment of the vertical distribution of hydraulic conductivity in the vicinity of newly constructed extraction well 299-W15-225. The hydrologic characterization approach presented in this report is expected to have universal application for meeting the characterization needs at other remedial action sites located within unconfined and confined aquifer systems.

  10. 225名健康儿童建立呼出气一氧化氮正常值%Reference values and determinants of fractional exhaled nitric oxide in 225 healthy children in Suzhou

    Institute of Scientific and Technical Information of China (English)

    刘媛媛; 陆燕红; 郝创利

    2012-01-01

    目的 探讨6~14岁儿童呼出气一氧化氮(FeNO)正常值范围及其影响因素.方法 选取苏州市6~14岁在校儿童进行问卷调查及FeNO、肺功能、外周血嗜酸粒细胞(EOS)计数的检测,筛选出健康儿童建立FeNO正常值.FeNO的测定采用电化学法,根据美国胸科学会/欧洲呼吸学会指南进行操作.分析性别、年龄、身高、体重、外周血EOS计数、肺功能和FeNO的相关性.结果 参与调查的450名儿童中符合纳入标准者225名(男生107名,女生118名)进入分析.FeNO值呈偏态分布,经自然对数转换后呈正态分布.FeNO平均值为11 ppb(95%CI:5~28 ppb),最小值9岁儿童FeNO显著高于≤9岁儿童(P=0.002);FeNO与性别、体重、BMI、FEV1/FVC无显著相关性.结论 苏州地区6~14岁儿童FeNO正常参考值为5~28 ppb;FeNO水平与外周血EOS计数、身高、FEV1显著相关.%Objectives The aim of this study was to establish FeNO reference values for healthy school-aged children in Suzhou according to the international guidelines, and to assess the determinants of FeNO. Methods Children aged 6-14 years were recruited from two public schools in Suzhou. The subjects completed a respiratory questionnaire, and were examined with measurements of FeNO, spirometry and blood eosinophil. Healthy children were screened to establish reference values of FeNO. FeNO was measured with a chemiluminescence analyzer according to American Thoracic Society guidelines ( single breath online, exhalation flow 50 mL · s-1 ). The associations between different determinants ( sex, age, height, weight, BMI, peripheral blood EOS count, FEV1/FVC, lung function) and FeNO were analyzed. Results Finally, a total of 450 children participated in the study, and 225 children fulfilled the inclusion criteria of healthy subjects ( 107 boys and 118 girls ). FeNO data were skewed, and met normal distribution after natural logarithm transformation. The geometric mean of FeNO in 225 children was 11 parts per

  11. The Molecular Gas Environment around Two Herbig Ae/Be Stars: Resolving the Outflows of LkHα 198 and LkHα 225S

    Science.gov (United States)

    Matthews, Brenda C.; Graham, James R.; Perrin, Marshall D.; Kalas, Paul

    2007-12-01

    Observations of outflows associated with pre-main-sequence stars reveal details about morphology, binarity, and evolutionary states of young stellar objects. We present molecular line data from the Berkeley-Illinois-Maryland Association array and Five Colleges Radio Astronomical Observatory toward the regions containing the Herbig Ae/Be stars LkHα 198 and LkHα 225S. Single-dish observations of 12CO J=1-0, 13CO J=1-0, N2H+ J=1-0, and CS J=2-1 were made over a field of 4.3'×4.3' for each species. 12CO J=1-0 data from FCRAO were combined with high-resolution BIMA array data to achieve a naturally weighted synthesized beam of 6.75''×5.5'' toward LkHα 198 and 5.7''×3.95'' toward LkHα 225S, representing resolution improvements of factors of approximately 10 and 5 over existing data. By using uniform weighting, we achieved another factor of 2 improvement. The outflow around LkHα 198 resolves into at least four outflows, none of which are centered on LkHα 198-IR, but even at our resolution we cannot exclude the possibility of an outflow associated with this source. In the LkHα 225S region we find evidence for two outflows associated with LkHα 225S itself, and a third outflow is likely driven by this source. Identification of the driving sources is still resolution limited and is also complicated by the presence of three clouds along the line of sight toward the Cygnus molecular cloud. 13CO J=1-0 is present in the environments of both stars along with cold, dense gas as traced by CS J=2-1 and (in LkHα 225S) N2H+ J=1-0. No 2.6 mm continuum is detected in either region in relatively shallow maps compared to existing continuum observations.

  12. Dense Core Properties in the Infrared Dark Cloud G14.225-0.506 Revealed by ALMA

    Science.gov (United States)

    Ohashi, Satoshi; Sanhueza, Patricio; Chen, Huei-Ru Vivien; Zhang, Qizhou; Busquet, Gemma; Nakamura, Fumitaka; Palau, Aina; Tatematsu, Ken'ichi

    2016-12-01

    We have performed a dense core survey toward the Infrared Dark Cloud G14.225-0.506 at 3 mm continuum emission with the Atacama Large Millimeter/Submillimeter Array (ALMA). This survey covers the two hub-filament systems with an angular resolution of ˜ 3\\prime\\prime (˜0.03 pc). We identified 48 dense cores. 20 out of the 48 cores are protostellar due to their association with young stellar objects (YSOs) and/or X-ray point-sources, while the other 28 cores are likely prestellar and unrelated with known IR or X-ray emission. Using APEX 870 μm continuum emission, we also identified the 18 clumps hosting these cores. Through virial analysis using the ALMA N2H+ and VLA/Effelsberg NH3 molecular line data, we found a decreasing trend in the virial parameter with decreasing scales from filaments to clumps, and then to cores. The virial parameters of 0.1-1.3 in cores indicate that cores are likely undergoing dynamical collapse. The cumulative core mass function for the prestellar core candidates has a power law index of α =1.6, with masses ranging from 1.5 to 22 {M}⊙ . We find no massive prestellar or protostellar cores. Previous studies suggest that massive O-type stars have not been produced yet in this region. Therefore, high-mass stars should be formed in the prestellar cores by accreting a significant amount of gas from the surrounding medium. Another possibility is that low-mass YSOs become massive by accreting from their parent cores that are fed by filaments. These two possibilities might be consistent with the scenario of global hierarchical collapse.

  13. Comment: 225 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available itute of Agrobiological Sciences), Daiki Horikawa (NASA Ames Research Center) licenced under CC Attribution2....1 Japan ヨコヅナクマムシ 電子顕微鏡写真 撮影:行弘文子(農業生物資源研究所)、堀川大樹(NASA Ames Research Center) bando 2010/02/15 14:55:04 2010/02/16 10:43:01 ...

  14. Microstructures of Al7.5Cr22.5Fe35Mn20Ni15 High-Entropy Alloy and Its Polarization Behaviors in Sulfuric Acid, Nitric Acid and Hydrochloric Acid Solutions

    Directory of Open Access Journals (Sweden)

    Chun-Huei Tsau

    2016-08-01

    Full Text Available This paper investigates the microstructures and the polarization behaviors of Al7.5Cr22.5Fe35Mn20Ni15 high-entropy alloy in 1M (1 mol/L deaerated sulfuric acid (H2SO4, nitric acid (HNO3, and hydrochloric acid (HCl solutions at temperatures of 30–60 °C. The three phases of the Al7.5Cr22.5Fe35Mn20Ni15 high-entropy alloy are body-centered cubic (BCC dendrites, face-centered cubic (FCC interdendrites, and ordered BCC precipitates uniformly dispersed in the BCC dendrites. The different phases were corroded in different acidic solutions. The passivation regions of the Al7.5Cr22.5Fe35Mn20Ni15 alloy are divided into three and two sub-regions in the solutions of H2SO4 and HNO3 at 30–60 °C, respectively. The passivation region of the Al7.5Cr22.5Fe35Mn20Ni15 alloy is also divided into two sub-domains in 1M deaerated HCl solution at 30 °C. The Al7.5Cr22.5Fe35Mn20Ni15 alloy has almost equal corrosion resistance in comparison with 304 stainless steel (304SS in both the 1M H2SO4 and 1M HCl solutions. The polarization behaviors indicated that the Al7.5Cr22.5Fe35Mn20Ni15 alloy possessed much better corrosion resistance than 304SS in 1M HNO3 solution. However, in 1M NaCl solution, the corrosion resistance of the Al7.5Cr22.5Fe35Mn20Ni15 alloy was less than 304SS.

  15. Novel BAC mouse model of Huntington’s disease with 225 CAG repeats exhibits an early widespread and stable degenerative phenotype

    Science.gov (United States)

    Wegrzynowicz, Michal; Bichell, Terry Jo; Soares, Barbara D.; Loth, Meredith K.; McGlothan, Jennifer L.; Alikhan, Fatima S.; Hua, Kegang; Coughlin, Jennifer M.; Holt, Hunter K.; Jetter, Christopher S.; Mori, Susumu; Pomper, Martin G.; Osmand, Alexander P.; Guilarte, Tomás R.; Bowman, Aaron B.

    2015-01-01

    BACKGROUND Unusually large CAG repeat expansions (>60) in exon one of Huntingtin (HTT) are invariably associated with a juvenile-onset form of Huntington’s disease (HD), characterized by a more extensive and rapidly progressing neuropathology than the more prevalent adult-onset form. However, existing mouse models of HD that express the full-length Htt gene with CAG repeat lengths associated with juvenile HD (ranging between ~75 to ~150 repeats in published models) exhibit selective neurodegenerative phenotypes more consistent with adult-onset HD. OBJECTIVE To determine if a very large CAG repeat (>200) in full-length Htt elicits neurodegenerative phenotypes consistent with juvenile HD. METHODS Using a bacterial artificial chromosome (BAC) system, we generated mice expressing full-length mouse Htt with ~225 CAG repeats under control of the mouse Htt promoter. Mice were characterized using behavioral, neuropathological, biochemical and brain imaging methods. RESULTS BAC-225Q mice exhibit phenotypes consistent with a subset of features seen in juvenile-onset HD: very early motor behavior abnormalities, reduced body weight, widespread and progressive increase in Htt aggregates, gliosis, and neurodegeneration. Early striatal pathology was observed, including reactive gliosis and loss of dopamine receptors, prior to detectable volume loss. HD-related blood markers of impaired energy metabolism and systemic inflammation were also increased. Aside from an age-dependent progression of diffuse nuclear aggregates at 6 months of age to abundant neuropil aggregates at 12 months of age, other pathological and motor phenotypes showed little to no progression. CONCLUSIONS The HD phenotypes present in animals 3 to 12 months of age make the BAC-225Q mice a unique and stable model of full-length mutant Htt associated phenotypes, including body weight loss, behavioral impairment and HD-like neurodegenerative phenotypes characteristic of juvenile-onset HD and/or late-stage adult

  16. Comparison of Structures and Dielectric Properties of Bi1.65Zn1.0Nb1.5O7.225 Ceramic and Thin Film%Bi1.65Zn1.0Nb1.5O7.225陶瓷和薄膜的结构和介电性能对比

    Institute of Scientific and Technical Information of China (English)

    张效华; 辛凤; 胡跃辉; 杨丰; 陈义川

    2012-01-01

    Based on the Bi1.5Zn1.0Nb1.5O7 formula, the non-stoichiometric pyrochlore Bi1.65 Zn1.0 Nb1.5 O7.225 (BZN) ceramic was prepared by adding the Bi2O3 with 10 mol% excess amount. Bi1.65 Zn1.0 Nb1.5 O7.225 ceramics were prepared by the conventional solid-state reaction technology. Thin films were prepared on Pt/ SiO2/Si(100) substrates by pulsed laser deposition. Bi1.65Zn1.0Nb1.5 O7.225 ceramic and thin film was compared to investigate the difference of crystallinity, microstructure and dielectric properties. The results indicated that the sintered BZN ceramic and the deposited BZN thin films have a pure cubic pyrochlore structure, however, BZN thin film exhibits the strong preferential orientation of (222) plane. The lattice constant and microstructure between ceramic and thin film also both exhibit the obvious difference. After contrast the dielectric properties of ceramic and thin film, it can be concluded that the dielectric constant of BZN thin film is significantly larger than that of BZN ceramic, which can be attributed to the difference between bulk ceramic and thin film, such as thickness, density and the preferential orientation, etc.%以立方焦绿石Bi1.5Zn1.0Nb1.5O7(BZN)为配方基础,通过掺入过量10%的Bi2O3,形成Bi1.65Zn1.0Nb1.5O7.225非化学计量比分子式.采用固相反应法合成具有焦绿石立方结构的Bi1.65Zn1.0Nb1.5O7.225陶瓷,并采用脉冲激光沉积法在Pt/SiO2/Si(100)基片上制备其薄膜.对比研究了非化学计量比Bi1.5Zn1.0Nb1.5O7.225陶瓷和薄膜的结晶性能,微观形貌以及介电性能的差异.结果表明烧结的Bi1.65Zn1.0Nb1.5O7.225陶瓷和沉积的BZN薄膜都保持立方焦绿石单相结构,但是薄膜展现出较强的(222)晶面择优取向.陶瓷和薄膜的晶格常数,微观形貌都体现出差异.对比二者的介电特性后发现,Bi1.65Zn1.0Nb1.5O7.225薄膜的介电常数明显高于陶瓷的介电常数,这归因于薄膜和块体材料之间的差异,例如厚度,致密度,择优取向等.

  17. (INCONSTITUCIONALIDAD DE LA REGLA DE ATRIBUCIÓN PREFERENTE MATERNA DEL CUIDADO PERSONAL DE LOS HIJOS DEL ARTÍCULO 225 DEL CÓDIGO CIVIL CHILENO (Unconstitutionality of the preference towards the mother of the legal attribution of child physical custody of the article 225 section of the chilean civil code

    Directory of Open Access Journals (Sweden)

    Fabiola Lathrop Gómez

    2010-01-01

    Full Text Available El presente artículo sostiene que la norma de atribución preferente materna del cuidado personal de los hijos, contenida en el artículo 225 del Código Civil chileno, es inconstitucional, pues se funda en una discriminación arbitraria, injusta, no razonable y desproporcionada, vulneradora del principio de igualdad jurídica y material. Se analiza el caso chileno a la luz de los Tratados Internacionales de Derechos Humanos y del Derecho Comparado.The present article sustains that the preference towards the mother of the legal attribution of physical custody container] in the article 225 of the Chilean Civil Code, is unconstitutional, since is based in an arbitrary discrimination, unjust, not reasonable and disproportionate, that violates the principie of legal and material equality The Chilean case is analyzed in the light of International Human Rights Treaties and Comparative Law.

  18. Evaluation of AK-225(R), Vertrel(R) MCA and HFE A 7100 as Alternative Solvents for Precision Cleaning and Verification Technology

    Science.gov (United States)

    Melendez, Orlando; Trizzino, Mary; Fedderson, Bryan

    1997-01-01

    The National Aeronautics and Space Administration (NASA), Kennedy Space Center (KSC) Materials Science Division conducted a study to evaluate alternative solvents for CFC-113 in precision cleaning and verification on typical samples that are used in the KSC environment. The effects of AK-225(R), Vertrel(R), MCA, and HFE A 7100 on selected metal and polymer materials were studied over 1, 7 and 30 day test times. This report addresses a study on the compatibility aspects of replacement solvents for materials in aerospace applications.

  19. Application of Electron Energy Loss Spectroscopy and Energy Filtering Transmission Electron Microscopy for Microchemical Studies in 2.25Cr-1Mo Steel

    Institute of Scientific and Technical Information of China (English)

    P. Parameswaran; Ilse Papst; F. Hofer; W. Grogger; V.S. Raghunathan

    2005-01-01

    Electron enregy loss spectroscopy (EELS) and energy filtering transmission electron microscopy (EFTEM) investigation on 2.25Cr-1Mo steel was carried out to understand the nature of evolution of secondary carbides. The filtered images obtained from two different ageing treatments indicate that the steel evolves to a more stable carbide namely M23C6 in comparison to M2C. Microchemical information was generated from EELS spectra. Suitable choice for estimating the microchemical state was discussed. To evaluate the behaviour of ageing an elemental ratio of Fe to Cr is employed.

  20. Absolute frequency measurement of the 7s$^2$ $^1$S$_0$ $-$ 7s7p $^{1}$P$_1$ transition in $^{225}$Ra

    CERN Document Server

    Santra, B; Groot, A; Jungmann, K; Willmann, L

    2014-01-01

    Transition frequencies were determined for transitions in Ra in an atomic beam and for reference lines in Te$_2$ molecules in a vapor cell. The absolute frequencies were calibrated against a GPS stabilized Rb-clock by means of an optical frequency comb. The 7s$^2\\,^1$S$_0$(F = 1/2)-7s7p$\\,^1$P$_1$(F = 3/2) transition in $^{225}$Ra was determined to be $621\\,042\\,124(2)\\,$MHz. The measurements provide input for designing efficient and robust laser cooling of Ra atoms in preparation of a search for a permanent electric dipole moment in Ra isotopes.

  1. 并存糖尿病病人的围手术期处理(附225例报告)%Perioperative Management of Patients with Diabtes Melltitus

    Institute of Scientific and Technical Information of China (English)

    谢加东

    2001-01-01

    225例并存糖尿病病人的围手术期处理后的情况进行了报道,该组病例中,择期手术126例,急诊手术99例.应用胰岛素治疗或改善血糖水平,并纠正酮症和酸中毒.本组病例术后并发症为17.78%,以切口感染、不愈合多见.

  2. 靶向纳米造影剂C225-USPIO标记裸鼠鼻咽癌移植瘤MR成像研究%Studies on MR Imaging of Nude Mice Bearing Nasopharyngeal Carcinoma Xenograft by Using Targeted Nano-Contrast Agent C225-USPIO

    Institute of Scientific and Technical Information of China (English)

    钱莹; 龙国贤; 刘东伯; 胡国清

    2012-01-01

    Objective: This work aimed to design epidermal growth factor receptor-targeted contrast agent C225-USPIO and to evaluate its magnetic resonance imaging (MRI) capability to mark the nasopharyngeal carcinoma xenograft in nude mice. Methods: C225-USPIO was designed by conjugating ultra-small superparamagnetic iron oxide (USPIO) nanoparticles with cetuximab (C225). The diameter of C225-USPIO was detected. Nasopharyngeal carcinoma cells SUNE1 5-8F with EGFR overexpression were transplanted into the ventral subcutaneous site of the right rear thigh of 12 nude mice. When the diameter of a transplanted tumor reached 5 mm, the nude mice were randomly divided into two groups, i.e., the experiment group (Group One) and the control group (Group Two), with 6 mice in each group. C225-USPIO and USPIO were separately injected into the mice through the caudal vein. MRI T2 weighted image (T2WI) scanning was conducted 0, 8, 24 and 72 h after the injection. The nano-contrast agent distribution in the tumor tissues was detected. Results: The diameter of the contrast agent ranged from 45 run to 50 nm. MRI results showed that compared with the value of T2WI signal intensity 0 h after the contrast agent injection, the T2 value of the xenograft tumor in Group One was slightly decreased 8 h after the injection (P>0.05). The value was significantly decreased 24 h after the injection (P<0.05), and no apparent change in the T2 value was observed 72 h after the injection (P>0.05). In Group Two, no significant changes in the T2 value of xenograft tumor after the USPIO injection were observed at each time point. No significant iron particles were found in the tumor tissue 72 h after the injection. Conclusion: C225-USPIO particles could pass through blood capillaries and could be applied for MR imaging in vivo. In addition, they can reduce MRI T2 signal intensity of the xenograft in nude mice with a certain specificity and targeting property.%目的:制备针对EGFR的靶向纳米造影剂C225

  3. Core-polarization studies of nuclear-Schiff-moment-induced permanent electric dipole moments of atomic Xe129, Yb171, and Ra225

    Science.gov (United States)

    Ramachandran, S. M.; Latha, K. V. P.

    2014-10-01

    We have calculated the intrinsic electric dipole moments (EDMs) of Xe129, Yb171, Ra225 atoms induced by the nuclear Schiff moment (NSM). We use the coupled perturbed Hartree-Fock [CPHF] framework to perform this calculation. In this work, the effects of electron correlation on atomic EDMs are studied in CPHF framework by gradual inclusion of virtual orbitals of higher symmetries. Individual orbital contributions to the final magnitude of the EDM are presented. The results for the NSM-induced EDM for these atoms show a trend similar to the electron-nucleon tensor-pseudotensor (T-PT)-induced EDM, the study of which was performed elsewhere. This behavior can be attributed to the fact that the influence of virtual orbitals of higher symmetry on the magnitude of EDM is essentially the same for both T-PT and NSM-induced atomic EDMs. However, we also report in this paper, that the most dominant contribution to the atomic EDM of Xe129, Yb171, Ra225 atoms induced by the NSM arises from the s1/2-p3/2 pairings rather than the s1/2-p1/2 pairings, which were the dominantly contributing pairings for the electron-nucleon tensor-pseudotensor-induced atomic EDM.

  4. Análisis mediante HPLC de la fracción fenólica del aceite de oliva virgen de la variedad Arbequina. Relación con la medida del amargor K225 y la estabilidad

    Directory of Open Access Journals (Sweden)

    Uceda, M.

    2000-10-01

    Full Text Available Phenolic compounds have a high importance because of their effect on shelf life and sensorial characteristics of virgin olive oil. In this paper, the phenolic fraction of Arbequina virgin olive oils has been characterized by HPLC. Bitterness index K225, total phenols and autoxidation stability have been evaluated for olive oil samples. From the phenolic compounds separated using HPLC method, one of then (tr: 34,49 min was close correlated both with bitterness K225 and oil stability Rancimat at 98ºC. The regression coefficients, with high significance p<0,001, were r: 0.974 and r: 0.918 respectively. Phenolic compound responsible of bitterness K225 and oil stability has been found for the Arbequina virgin olive oils.Los compuestos fenólicos tienen gran importancia por su efecto sobre la estabilidad y las características sensoriales de los aceites de oliva vírgenes. En este trabajo se ha analizado mediante cromatografía líquida de alta resolución la fracción fenólica de los aceites de oliva de la variedad Arbequina. Se han determinado el amargor K225, el contenido de polifenoles totales y la estabilidad de los aceites. De los compuestos fenólicos separados por HPLC, existe uno de ellos, con un tr: 34,49 min que presenta un elevado nivel de correlación con el amargor K225 y la estabilidad Rancimat a 98ºC, presentando unos coeficientes de regresión altamente significativos, p<0.001, de r: 0.974 y r: 0.918 respectivamente. Por tanto, se ha establecido el principal responsable del amargor K225 y la estabilidad oxidativa de los aceites de la variedad Arbequina.

  5. An analysis on the prognosis in 225 patients with spontaneous intracerebral hemorrhage and inspection of the forecast model%自发性脑出血225例预后分析及其预测模型

    Institute of Scientific and Technical Information of China (English)

    甄志刚; 张秋莲; 张生; 高志红; 彭延波; 王晋朝

    2014-01-01

    Objective It is tO investigate the risk factOrs related tO prOgnOsis On 3 mOnth in patients with spOntaneOus in-tracerebral hemOrrhage(ICH)and tO evaluate the fOrecast mOdel. Methods TwO hundred and twenty-five patients with ICH were cOllected and their data was retrOspectively analyzed. The prOgnOsis On 3 mOnth was evaluated by the mOdified Rankin Scale(mRS)scOre. Univariate analysis was perfOrmed tO find risk factOrs related tO favOrable prOgnOsis(mRS≤2)and unfa-vOrable prOgnOsis(mRS>2). At last,multivariate LOgistic analysis was perfOrmed tO find independent risk factOrs assOciated tO unfavOrable prOgnOsis. AccOrding tO the independent risk factOrs,the fOrecast mOdel was established and its reliability was evaluated. Results Multivariate LOgistic regressiOn analysis indicated that age,NIHSS scOre On admissiOn,early enlargement Of hematOma Or nOt and with histOry Of intracerebral hemOrrhage Or nOt were independent influencing factOrs fOr prOgnOsis in 3 mOnth. AccOrdingly,a fOrecast mOdel was established and the mOdel's sensitivity,specificity and tOtal accuracy was 66. 7%, 82. 7% and 76. 1%. Conclusion In ICH patients,advanced age,higher NIHSS scOre On admissiOn,early enlargement Of he-matOma and histOry Of intracerebral hemOrrhage are earlier predictOrs fOr unfavOurable OutcOme.%目的:探讨自发性脑出血( ICH)3个月预后相关危险因素,并对预测模型进行考察分析。方法回顾性分析225例 ICH 患者资料,采用 mRS 评分对患者3个月时预后情况进行评价。首先进行单因素分析,筛选与预后良好( mRS≤2分)或预后不良( mRS≥3分)相关的因素;其次以3个月预后良好与否进行多因素 LOgistic回归分析,探讨与预后相关的独立危险因素。最后,根据相关独立危险因素,建立预测模型并进行可靠性考察。结果年龄、入院时 NIHSS评分、有无 ICH后早期血肿扩大及既往有无脑出血史为3个月预后的独

  6. Prediction of the Residual Welding Stress in 2.25Cr-1Mo Steel by Taking into Account the Effect of the Solid-State Phase Transformations

    Institute of Scientific and Technical Information of China (English)

    Dean DENG; Yangang TONG; Ninshu MA; Hidekazu MURAKAWA

    2013-01-01

    A computational approach based on the thermal elastic plastic finite element method was developed for predicting welding residual stress in low carbon alloyed steel welds by taking into account the effect of the solid-state phase transformations.The kinetics of phase transformations was described by Johnson Mehl Avrami Kolmogrov (JMAK) equation for bainitic transition and by Koistinen-Marburger (K-M) relationship for martensitic transition.Moreover,an additive rule depending on volumetric phase fraction was adopted to represent the material property changes during heating and cooling.Consequently,the residual welding stresses in a 2.25Cr1Mo steel TIG welded plate were computed.Early calculation results suggest that the bainitic and martensitic transformations took place in the weld the heat-affected zone drastically reduce the residual longitudinal tensile stress in the region.

  7. Equation of state of Zr41 Ti14 Cu12.5 Ni10 Be22.5 bulk metallic glass

    Institute of Scientific and Technical Information of China (English)

    ZHAN Zai-ji; LIU Qiu-yun; ZHENG Run-guo; WANG Wen-kui; LIU Jing

    2007-01-01

    The knowledge of the equation of state (EOS) and the compressibilityof a solid are of central importance for the understanding of the behavior and the application of a condensed matter. The compression behavior of Zr41 Ti14Cu12.5Ni10Be22.5 bulk metallic glass (BMG) is investigated at room temperature up to 24 GPa using in-situ high pressure energy dispersive X-ray diffraction with synchrotron radiation. A model of basic cell volume has been established and the equation of state of BMG is determined by the calculation of radial distribution function. The experimental results indicate that the BMG contains a large amount of vacancy-like free volume.Low pressure ( below 7 GPa) induces the collapse of the free volume to some extent and structure relaxation in the BMG.

  8. Analysis of the nature of excessive cosmic radiation in the area of the Brazilian magnetic anomaly at altitudes 250-500km, from Kosmos-225 satellite data

    Science.gov (United States)

    Raychenko, L. V.

    1974-01-01

    Results are presented from a study of the region of anomalous cosmic radiation in the area of the Brazilian magnetic anomaly at the altitudes 250-500 km, using data measurements taken on the Kosmos-225 satellite (14-29 June 1968). The existence of a stable intensity anomaly discovered in the experiments on the second and third Soviet spacecraft-satellites is confirmed. The total vector of the geomagnetic field at different altitudes was compared with isoline maps. An altitude profile of the South Atlantic anomaly of radiation intensity was obtained, using data from the same instrument. The nature of the anomalies in cosmic radiation intensity over the regions of negative magnetic anomalies is discussed.

  9. Use of Radioactive Ion Beams for Biomedical Research 1. in vivo labelling of monoclonal antibodies with radio-lanthanides and $^{225}$Ac

    CERN Multimedia

    2002-01-01

    % IS330 \\\\ \\\\\\begin{enumerate} \\item The aim of this study was to contribute to developments of new radiopharmaceuticals for tumour diagnosis and therapy. CERN-ISOLDE is the leading facility in the world to provide radioactive ion beams with high selectivity, purity and intensity. Radioisotope production by spallation makes available a complete range of rare earth isotopes having as complete a diversity of types and energy of radiation, of half-life, and of ionic properties as one would wish. The availability of exotic nuclei, e.g. radionuclides of rare earth elements and $^{225}$Ac, opens new possibilities for the development of radiopharmaceuticals for diagnosis and therapy.\\\\ \\\\ \\item Two approaches were followed within the experimental program. The radioactive metal ions are bound either to bio-specific ligands (monoclonal antibodies or peptides) or to unspecific low molecular weight form. The aim of the experimental program is to evaluate relationships between physico-chemical parameters of the tracer m...

  10. Studies on Hot Corrosion of the Microstructurally Different Regions of 2.25Cr-1Mo (T22) Boiler Tube Steel Weldment

    Science.gov (United States)

    Kumar, Ravindra; Tewari, V. K.; Prakash, Satya

    2009-10-01

    This study examines the effect of microstructurally different regions on the hot corrosion of tungsten inert gas weldment in 2.25Cr-1Mo (T22) boiler tube steel. Various regions of weldment were oxidized in molten salt Na2SO4-60% V2O5 environment at 900 °C. The base metal was found to oxidize at much higher rates than the weld metal and the heat-affected zone. Oxide scales formed in the three regions were compared by scanning electron microscopy with energy dispersive of X-ray analysis, X-ray diffraction pattern, and electron probe microanalysis. The research investigates the formation of inner scales with free Cr over the HAZ.

  11. “Direct modulation of a hybrid III-V/Si DFB laser with MRR filtering for 22.5-Gb/s error-free dispersion-uncompensated transmission over 2.5-km SSMF

    DEFF Research Database (Denmark)

    Cristofori, Valentina; Da Ros, Francesco; Ding, Yunhong;

    2016-01-01

    Error-free and penalty-free transmission over 2.5 km SSMF of a 22.5 Gb/s data signal from a directly modulated hybrid III-V/Si DFB laser is achieved by enhancing the dispersion tolerance using a silicon micro-ring resonator....

  12. Evaluation of [18F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood-brain barrier in rats: Kinetics, metabolism, and selectivity.

    NARCIS (Netherlands)

    Savolainen, Heli; Windhorst, Albert D.; Elsinga, Philip H.; Cantore, Mariangela; Colabufo, Nicola A.; Willemsen, Antoon T.M.; Luurtsema, Geert

    2016-01-01

    P-glycoprotein is a protective efflux transporter at the blood-brain barrier showing altered function in many neurological disorders. The purpose of this study was to validate [18F]MC225 as a radiotracer for measuring P-glycoprotein function with positron emission tomography. Three groups of Sprague

  13. Assessing the efficacy of 2 years of maintenance treatment with venlafaxine extended release 75–225 mg/day in patients with recurrent major depression: a secondary analysis of data from the PREVENT study

    Science.gov (United States)

    Kornstein, Susan G.; Kocsis, James H.; Ahmed, Saeeduddin; Thase, Michael; Friedman, Edward S.; Dunlop, Boadie W.; Yan, Bing; Pedersen, Ron; Ninan, Philip T.; Li, Thomas; Keller, Martin

    2013-01-01

    The objective of this study was to evaluate the long-term efficacy of venlafaxine extended release (ER) ≤225 mg/ day in patients with recurrent major depressive disorder (MDD). In this double-blind trial, outpatients with recurrent MDD (N=1096) were randomized to 10 weeks of acute-phase treatment with venlafaxine ER (75–300 mg/ day) or fluoxetine (20–60 mg/day) followed by a 6-month continuation phase and two consecutive 12-month maintenance phases. At the start of each maintenance period, venlafaxine ER responders were randomized to double-blind venlafaxine ER or placebo. In this analysis, data from responders to acute and continuation treatment were analyzed during the combined maintenance phases while receiving venlafaxine ER ≤225 mg/day. Failure to maintain response was defined as an increase in maintenance dose to 300 mg/day or recurrence. Differences were calculated using Kaplan–Meier methods and compared using log-rank tests. Continuation-phase responders (n =114) receiving venlafaxine ER ≤225 mg/ day comprised the analysis population (venlafaxine ER: n= 55; placebo: n= 59). The estimated probability for remaining well across 24 months of maintenance treatment was 67% for venlafaxine ER and 41% for placebo (P = 0.007). Venlafaxine ER effectively maintained response at doses ≤225 mg/day for up to 2.5 years in patients with recurrent MDD. The findings are consistent with those of the full data set. PMID:18854724

  14. 均匀化退火对Mg-3Al-1Zn-2.2/5Sr镁合金中第二相的影响%Effect of Homogenization Annealing on Second Phases in Mg-3Al-1Zn-2.2/5Sr Magnesium Alloys

    Institute of Scientific and Technical Information of China (English)

    吴菊英; 吴璐; 潘复生; 杨明波; 汤爱涛; 唐华

    2014-01-01

    为研究均匀化退火处理对Mg-3Al-1Zn-2.2/5Sr镁合金中第二相的影响,通过X射线衍射分析(XRD)、扫描电镜观察(SEM)和能谱分析(EDS)等手段,并结合Pandat热力学计算软件,对Mg-3Al-1Zn-2.2/5Sr镁合金均匀化退火后组织中的第二相的类型及形成原因进行了分析.结果表明:经过400℃,15h(炉冷)的均匀化退火处理以后,合金铸态组织中原本存在的(Mg,Al)17Sr2相中固溶的Al元素所占原子分数有所降低.此外,Sr含量为2.2%(质量分数)的合金组织中可以观察到大量沿(Mg,Al)17Sr2相边缘分布的颗粒状Al4Sr相,而Sr含量为5%的合金中基本观察不到(Mg,Al)17Sr2相的变化.

  15. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  16. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  17. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  18. Cinética de degradación del naftaleno por células inmovilizadas húmedas de Bacillus alcalophilus cepa IDO-225

    Directory of Open Access Journals (Sweden)

    Roberto Rafael Núñez Moreira

    2004-01-01

    Full Text Available Numerosas han sido las investigaciones sobre el estudio de la biorremediación para su aplicación en la lucha para combatir la contaminación ambiental por hidrocarburos. El Instituto de Oceanología del Ministerio de Ciencia, Tecnología y Ambiente, ha trabajado desde 1988 en el aislamiento y conservaci ón de bacterias marinas que sean capaces de degradar el petróleo. Actualmente, cuenta con cuatro bioproductos degradadores de petróleo en medio marino denominados BIOIL, K-BIOIL, BIOIL-FC e IDO-225. En el presente trabajo, se demuestra por Espectroscopia Infrarroja de las muestras extraídas a los 3, 6, 9, 12 y 15 d de contacto de las células húmedas inmovilizadas de Bacillus alcalophilus cepa IDO-225 en el medio de degradación con el naftaleno, un hidrocarburo del petróleo, que estas son capaces de degradar el naflateno como única fuente de carbono y energía. La degradación de este hidrocarburo por las células inmovilizadas de esta cepa se lleva a cabo mediante un mecanismo que se basa en un modelo cinético de segundo orden correspondiente a un mecanismo de metil-oxidación y b-oxidación, al igual que las células libres de dicha cepa, pero con la diferencia de que en el caso de las células inmovilizadas, el término cuadrático (metil-oxidación es mayor y el término lineal (b-oxidación es menor que en las células libres. En este mecanismo se produce acetil-CoA, el cual se incorpora al ciclo de los acidos tricarboxílicos para formar dióxido de carbono, agua y coenzimas reducidas, las cuales se dirigen a la cadena de transporte electrónica para obtener energía en forma de ATP y garantizar la síntesis de compuestos esenciales y la obtención de energía.

  19. Detection of charge scattering associated with stripe order in La1.775Sr0.225NiO4 by hard-x-ray diffraction

    Science.gov (United States)

    Vigliante, A.; von Zimmermann, M.; Schneider, J. R.; Frello, T.; Andersen, N. H.; Madsen, J.; Buttrey, D. J.; Gibbs, Doon; Tranquada, J. M.

    1997-10-01

    In the past few years neutron-scattering experiments have shown very intriguing stripe correlations of spins and holes in hole-doped La2NiO4 and La2CuO4. As yet, no x-ray-diffraction experiment has confirmed the neutron results and the topic is still controversial. In this paper we report the observation of stripe correlations of holes by x-ray diffraction. The experiments were performed in Laue geometry at the hard-x-ray beamline BW5 at HASYLAB on a crystal of La1.775Sr0.225NiO4 which was previously studied by neutron diffraction. Temperature dependences of the intensities and wave vectors of the charge-density-modulation peaks were characterized and found to be in good agreement with the neutron-scattering results. Interestingly, weak, temperature-dependent scattering was also observed at positions consistent with nonresonant x-ray magnetic scattering from the spin correlations; however, a definitive determination of its origin remains lacking.

  20. What is controlling the fragmentation process in the Infrared Dark Cloud G14.225-0.506? Differet level of fragmentation in twin hubs

    CERN Document Server

    Busquet, G; Palau, A; Liu, H B; Zhang, Q; Girart, J M; de Gregorio-Monsalvo, I; Pillai, T; Anglada, G; Ho, P T P

    2016-01-01

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225-0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 microns obtained with APEX and CSO telescopes. The large scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 microns and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be respon...

  1. Keck and VLT Observations of Super-damped Lyman-alpha Absorbers at z=2=2.5: Constraints on Chemical Compositions and Physical Conditions

    CERN Document Server

    Kulkarni, Varsha P; Morrison, Sean; Peroux, Celine; Quiret, Samuel; York, Donald G

    2015-01-01

    We report Keck/ESI and VLT/UVES observations of three super-damped Lyman-alpha quasar absorbers with H I column densities log N(HI) >= 21.7 at redshifts z=2-2.5. All three absorbers show similar metallicities (-1.3 to -1.5 dex), and dust depletion of Fe, Ni, and Mn. Two of the absorbers show supersolar [S/Zn] and [Si/Zn]. We combine our results with those for other DLAs to examine trends between N(HI), metallicity, dust depletion. A larger fraction of the super-DLAs lie close to or above the line [X/H]=20.59-log N(HI) in the metallicity vs. N(HI) plot, compared to the less gas-rich DLAs, suggesting that super-DLAs are more likely to be rich in molecules. Unfortunately, our data for Q0230-0334 and Q0743+1421 do not cover H2 absorption lines. For Q1418+0718, some H2 lines are covered, but not detected. CO is not detected in any of our absorbers. For DLAs with log N(HI) 21.7 may have somewhat narrower velocity dispersions delta v_90 than the less gas-rich DLAs, and may arise in cooler and/or less turbulent gas.

  2. Docosapentaenoic acid (22:5, n-3) suppressed tube-forming activity in endothelial cells induced by vascular endothelial growth factor.

    Science.gov (United States)

    Tsuji, Masako; Murota, Se-itsu; Morita, Ikuo

    2003-05-01

    It is generally accepted that n-3 polyunsaturated fatty acids have beneficial effects on vascular homeostasis. Among the several functions of endothelial cells, angiogenesis contributes to tumor growth, inflammation, and microangiopathy. We have already demonstrated that eicosapentaenoic acid (EPA, 20:5, n-3) suppressed angiogenesis. In this paper, we examined the effect of docosapentaenoic acid (DPA, 22:5, n-3), an elongated metabolite of EPA, on tube-forming activity in bovine aortic endothelial cells (BAE cells) incubated between type I collagen gels. The pretreatment of BAE cells with DPA suppressed tube-forming activity induced by vascular endothelial growth factor (VEGF). The effect of DPA was stronger than those of EPA and docosahexaenoic acid (22:6, n-3). The migrating activity of endothelial cells stimulated with VEGF was also suppressed by DPA pretreatment. The treatment of BAE cells with DPA caused the suppression of VEGF receptor-2 (VEGFR-2, the kinase insert domain-containing receptor, KDR) expression in both plastic dish and collagen gel cultures. These data indicate that DPA has a potent inhibitory effect on angiogenesis through the suppression of VEGFR-2 expression.

  3. 窒息新生儿225例血糖分析%Analysis of the blood sugar in asphyxial neonates

    Institute of Scientific and Technical Information of China (English)

    吴起武

    2009-01-01

    目的 探讨窒息新生儿血糖的变化.方法 对225例窒息新生儿和43例对照组新生儿进行血糖检测和分析.结果 窒息组和对照组血糖水平比较差异无统计学意义[(3.85±2.01)与(4.37±1.01),P>0.05],重度窒息组血糖水平和高血糖发生率均显著高于轻度窒息组(均P 0.05]. The quantity of blood sugar and the incidence rate of hyperglycosemia in seriously asphyxial group were more greater than slightly asphyxial group(P <0.01). The quantity of blood sugar in slighdy asphyxial group was less than the control group (P < 0.05). The quantiy of blood sugar in asphyxial premature infants was significantly less than asphyxial full-term infants(P < 0.05). Conclusions The blood sugar level in asphyxial neonates is relative to the degree of asphyxia and gestational age. The blood sugar in highly asphyxial neonates rise whereas in slightly as-phyxial neonates and asphyxial premature infants reduce.

  4. Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies: a single-institution study of 225 cases.

    Science.gov (United States)

    Xue, Wen; Sheng, Yan; Weng, Xiangqin; Zhu, Yongmei; Zhao, Yan; Xu, Pengpeng; Fei, Xiaochun; Chen, Xiaoyan; Wang, Li; Zhao, Weili

    2015-12-01

    Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow (BM) infiltration is more commonly present in mature T-cell lymphoid malignancies compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoid malignancies treated in a single institution. These included 29 cases of T-cell lymphoproliferative disorders (T-LPD, all with BM infiltration) and 196 cases of T-/natural-killer-cell lymphoma (T/NKCL, 56 with BM infiltration and 140 without BM infiltration). The estimated 5-year overall survival (OS) rates of T-LPD and T/NKCL were 96.6% and 37.3%, respectively. T-LPD patients were less likely to exhibit poor performance status, advanced disease stage, presence of B symptoms, or abnormal level of serum β-2 microglobulin. With similar pathological characteristics, T/NKCL patients with BM infiltration showed significantly lower response rates and shorter OS than those without BM infiltration (P = 0.0264 and P cell lymphoid malignancies.

  5. Radio galaxies in ZFOURGE/NMBS: no difference in the properties of massive galaxies with and without radio-AGN out to z = 2.25

    CERN Document Server

    Rees, G A; Norris, R P; Cowley, M J; Papovich, C; Glazebrook, K; Quadri, R F; Straatman, C M S; Allen, R; Kacprzak, G G; Labbe, I; Nanayakkara, T; Tomczak, A R; Tran, K -V

    2015-01-01

    In order to reproduce the high-mass end of the galaxy mass-distribution, some process must be responsible for the suppression of star-formation in the most massive of galaxies. Commonly Active Galactic Nuclei (AGN) are invoked to fulfil this role, but the exact means by which they do so is still the topic of much debate, with studies finding evidence for both the suppression and enhancement of star-formation in AGN hosts. Using the ZFOURGE and NMBS galaxy surveys, we investigate the host galaxy properties of a mass-limited (M$_{\\odot}$ $\\ge$ 10$^{10.5}$ M$_{\\odot}$), high-luminosity (L$_{1.4}$ $>$ 10$^{24}$ W Hz$^{-1}$) sample of radio-loud Active Galactic Nuclei to a redshift of z = 2.25. In contrast to low redshift studies, which associate radio-AGN activity with quiescent hosts, we find that the majority of z $>$ 1.5 radio-AGN are hosted by star-forming galaxies. Indeed, the stellar populations of radio-AGN are found to evolve with redshift in a manner that is consistent with the non-AGN mass-similar galax...

  6. Influence of Phase Constitution on Mechanical Performance of 12Ce-3Y-ZrO2/2.5 wt pct Al2O3 Composites

    Institute of Scientific and Technical Information of China (English)

    Shuigen HUANG; Lin LI; J.Vlugels; O.V.D.Biest

    2004-01-01

    The phase constitution of a composite consisting of 12 at. Pct CeO2-3 at. Pct Y2O3-ZrO2/2.5 wt pct Al2O3 (3Y12Ce2.5Al) was determined by thermodynamic calculation. It is a combination of 36.9 at. Pct cubic phase and 63.1 at. Pct tetragonal phase at 1450℃. Green compacts were fabricated by cold isostatic pressing with powder synthesized by coating technique, and pressureless sintered at 1450℃. The fracture toughness and Vickers hardness, evaluated by the micro-indentation method, are 2.02 Mpa·m1/2 and 11.395 Gpa, respectively. The addition of 3 at. Pct Y2O3 to 12 at. Pct CeO2-ZrO2 ceramic leads to drastically decrease in toughness compared to composites without yttria stabilizer. No monoclinic phase is detected on the surface of all the ground samples. The high content of cubic phase and lack of phase transformation can be attributed to the low toughness based on the thermodynamic prediction.

  7. Studies on Hot Corrosion of the 2.25 Cr-1Mo Boiler Tube Steel and Its Weldments in the Molten Salt Na2SO4-60 pct V2O5 Environment

    Science.gov (United States)

    Kumar, Ravindra; Tewari, V. K.; Prakash, S.

    2007-01-01

    Hot corrosion is mainly due to the dissolution of protective oxides in the molten salt at the metal surface and their reprecipitation at some other sites as nonprotective porous mass. The hot corrosion attack along the grain boundaries leading to subsurface precipitation of oxides and sulfides also contributes to weakening of material. Ferritic steel with 2.25Cr 1Mo is used widely as a candidate material in the steam generating system of power plants. Hot corrosion studies were conducted on 2.25Cr-1Mo unwelded as well as welded steel specimens with molten salt coated after exposure at 900 °C under cyclic conditions. The thermogravimetric technique was used to establish the kinetics of corrosion X-ray diffraction (XRD); scanning electron microscopy/energy-dispersive analysis (SEM/EDAX) was used to analyze the corrosion products.

  8. Kinetics of the Glass Transition of the Zr41Ti14Cu12.5Ni1oBe22.5 Alloy Solidified in a Drop Tube

    Institute of Scientific and Technical Information of China (English)

    李工; 孙力玲; 刘日平; 景勤; 张君; 李强; 王文魁

    2002-01-01

    Droplets of Zr41 Ti14Cu12.5Ni10Be22.5 glass-forming alloy with different sizes are solidified in a drop tube containerless process. The glass transition temperature Tg of Zr41 Ti14 Cu12.5Ni10Be22.5 glassy spheres solidified with different cooling rates is investigated by using a differential scanning calorimeter. It was found that all the amorphous spheres show an increase of Tg with the heating rate. The glassy spheres have a unique value for the glass transition activation energy E9 = 435.50 k J/mol, which is independent of cooling rate q. The insensitivity of Tg to q is interpreted by an extension of the free volume model for flow.

  9. 基于参数回归模型的2.25Cr-1Mo钢蠕变断裂时间统计分析%Statistical Analysis on Creep Rupture Life of 2.25Cr-1Mo Steel on the Basis of Parameter Regression Models

    Institute of Scientific and Technical Information of China (English)

    郑开云; 吾之英

    2013-01-01

    基于多种寿命数据分布,包括指数(Exponential)、对数正态(Log-Normal)、威布尔(Weibull)、广义Gamma以及对数罗吉斯提克(ILog-Logistic)分布,采用Manson-Haferd时间-温度参数模型对2.25Cr-1Mo(T22)钢的蠕变断裂时间进行了回归分析,对比研究了基于不同分布模型的蠕变断裂时间与温度和应力的关系、模型拟合优度以及各种模型蠕变断裂时间中位值与5%分位值的差异.结果表明:除Exponential分布模型不适用以外,Log-Normal、Weibull、广义Gamma和Log-Logistic分布模型均适用于蠕变断裂时间数据;这4种模型对蠕变断裂时间中位值的估计均相近,但是对低分位值的估计有所不同,特别是在数据分散度较大时,蠕变断裂时间低分位值的差异较为显著,其中Weibull分布模型的蠕变断裂时间低分位值显著低于其他模型,因此,宜采用多种分布模型对2.25Cr-1Mo钢进行综合统计分析,以正确预测其蠕变寿命或长时服役应力.

  10. Temperature and Field Dependences of Parameters of the Equivalent Circuit Elements of MIS Structures Based on MBE n-Hg0.775Cd0.225Te in the Strong Inversion Mode

    Science.gov (United States)

    Voitsekhovskii, A. V.; Nesmelov, S. N.; Dzyadukh, S. M.

    2016-11-01

    A technique is proposed for the determining the parameters of the equivalent circuit elements in strong inversion mode using the measurement results of the admittance of MIS structures based on n-Hg0.775Cd0.225Te grown by molecular beam epitaxy. It is shown that at 77 K and frequencies above 10 kHz, the capacitancevoltage characteristics of MIS structures based on n-Hg0.775Cd0.225Te with a near-surface graded gap layer have a high-frequency behavior with respect to the recharge time of surface states located near the Fermi level of intrinsic semiconductor. It is established that the electron concentration in the near-surface graded-gap layer exceeds an average concentration found by the Hall method by more than 2 times. The proposed technique was used for determining the temperature dependences of the insulator capacitance, capacitance and differential resistance of the space-charge region, and capacitance of the inversion layer in MIS structures based on n-Hg0.775Cd0.225Te without a graded-gap layer. The temperature and voltage dependences of the parameters of the equivalent circuit elements in strong inversion are calculated. The results of calculation are qualitatively consistent with the results obtained from the measurements of the admittance.

  11. Protein engineering of the archetypal nitroarene dioxygenase of Ralstonia sp. strain U2 for activity on aminonitrotoluenes and dinitrotoluenes through alpha-subunit residues leucine 225, phenylalanine 350, and glycine 407.

    Science.gov (United States)

    Keenan, Brendan G; Leungsakul, Thammajun; Smets, Barth F; Mori, Masa-aki; Henderson, David E; Wood, Thomas K

    2005-05-01

    Naphthalene dioxygenase (NDO) from Ralstonia sp. strain U2 has not been reported to oxidize nitroaromatic compounds. Here, saturation mutagenesis of NDO at position F350 of the alpha-subunit (NagAc) created variant F350T that produced 3-methyl-4-nitrocatechol from 2,6-dinitrotoluene (26DNT), that released nitrite from 23DNT sixfold faster than wild-type NDO, and that produced 3-amino-4-methyl-5-nitrocatechol and 2-amino-4,6-dinitrobenzyl alcohol from 2-amino-4,6-dinitrotoluene (2A46DNT) (wild-type NDO has no detectable activity on 26DNT and 2A46DNT). DNA shuffling identified the beneficial NagAc mutation G407S, which when combined with the F350T substitution, increased the rate of NDO oxidation of 26DNT, 23DNT, and 2A46DNT threefold relative to variant F350T. DNA shuffling of NDO nagAcAd also generated the NagAc variant G50S/L225R/A269T with an increased rate of 4-amino-2-nitrotoluene (4A2NT; reduction product of 2,4-dinitrotoluene) oxidation; from 4A2NT, this variant produced both the previously uncharacterized oxidation product 4-amino-2-nitrocresol (enhanced 11-fold relative to wild-type NDO) as well as 4-amino-2-nitrobenzyl alcohol (4A2NBA; wild-type NDO does not generate this product). G50S/L225R/A269T also had increased nitrite release from 23DNT (14-fold relative to wild-type NDO) and generated 2,3-dinitrobenzyl alcohol (23DNBA) fourfold relative to wild-type NDO. The importance of position L225 for catalysis was confirmed through saturation mutagenesis; relative to wild-type NDO, NDO variant L225R had 12-fold faster generation of 4-amino-2-nitrocresol and production of 4A2NBA from 4A2NT as well as 24-fold faster generation of nitrite and 15-fold faster generation of 23DNBA from 23DNT. Hence, random mutagenesis discovered two new residues, G407 and L225, that influence the regiospecificity of Rieske non-heme-iron dioxygenases.

  12. WHAT IS CONTROLLING THE FRAGMENTATION IN THE INFRARED DARK CLOUD G14.225–0.506?: DIFFERENT LEVELS OF FRAGMENTATION IN TWIN HUBS

    Energy Technology Data Exchange (ETDEWEB)

    Busquet, Gemma; Girart, Josep Miquel [Institut de Ciències de l’Espai (CSIC-IEEC), Campus UAB, Carrer de Can Magrans, S/N, E-08193, Cerdanyola del Vallès, Catalunya (Spain); Estalella, Robert [Departament d’Astronomia i Meteorologia, Institut de Ciències del Cosmos (ICC), Universitat de Barcelona (IEEC-UB), Martí i Franquès, 1, E-08028 Barcelona, Catalunya (Spain); Palau, Aina [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, P.O. Box 3-72, 58090 Morelia, Michoacán, México (Mexico); Liu, Hauyu Baobab; Ho, Paul T. P. [Academia Sinica Institute of Astronomy and Astrophysics, Taipei, Taiwan (China); Zhang, Qizhou [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); De Gregorio-Monsalvo, Itziar [European Southern Observatory (ESO), Karl-Schwarzschild-Str. 2, D-85748 Garching (Germany); Pillai, Thushara [Max Planck Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Anglada, Guillem, E-mail: busquet@ice.cat [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía, s/n, E-18008, Granada (Spain)

    2016-03-20

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225–0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 μm obtained with APEX and CSO telescopes. The large-scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 μm and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be responsible for determining the fragmentation level. We estimated several physical parameters, such as the level of turbulence and the magnetic field strength, and we found no significant differences between these hubs. The Jeans analysis indicates that the observed fragmentation is more consistent with thermal Jeans fragmentation compared with a scenario in which turbulent support is included. The lower fragmentation level observed in hub-N could be explained in terms of stronger UV radiation effects from a nearby H ii region, evolutionary effects, and/or stronger magnetic fields at small scales, a scenario that should be further investigated.

  13. Clinical and prognostic significance of aberrant T-cell marker expression in 225 cases of de novo diffuse large B-cell lymphoma and 276 cases of other B-cell lymphomas.

    Science.gov (United States)

    Tsuyama, Naoko; Ennishi, Daisuke; Yokoyama, Masahiro; Baba, Satoko; Asaka, Reimi; Mishima, Yuko; Terui, Yasuhito; Hatake, Kiyohiko; Takeuchi, Kengo

    2017-03-23

    Expression of T-cell markers, generally investigated for immunophenotyping of T-cell lymphomas, is also observed in several types of B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL). We previously reported that CD5 expression in DLBCL is an inferior prognostic factor in the era of rituximab. However, data regarding the frequencies, histological relevance, and prognostic importance of T-cell markers other than CD5 are currently unavailable. In the present study, we comprehensively evaluated the expression of T-cell markers (CD2, CD3, CD4, CD5, CD7, and CD8) in 501 B-cell lymphomas, including 225 DLBCLs, by flow cytometry and subsequent immunohistochemistry. T-cell markers other than CD5, such as CD2, CD4, CD7, and CD8, were expressed in 27 (5%) patients, and notably, all of these cases were classified as large B-cell lymphoma subtypes: 25 DLBCLs and 2 intravascular large B-cell lymphomas. CD5 and other T-cell markers were expressed in 15% (31/225) and 10% (25/225) of DLBCL cases, respectively. Five of them co-expressed CD5 and other T-cell markers. Retrospectively analyzing the prognostic relevance of T-cell markers in 169 patients with primary DLBCL treated with rituximab-based chemotherapy, we showed that only CD5 was a strong predictor of poor survival. This study provides information about the occurrence of T-cell markers other than CD5 in B-cell lymphomas, their frequent histological subtypes, and their prognostic significance in DLBCL. CD5 was reconfirmed as a negative prognostic marker in DLBCL patients receiving rituximab-inclusive chemotherapy, whereas T-cell markers other than CD5 were found to have no impact on clinicopathological and survival analyses.

  14. Existence of Fe{sup 4+} ions in Co{sub 2.25}Fe{sub 0.75}O{sub 4} spinel ferrite confirmed from SXRD and XANES spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Panda, Manas Ranjan, E-mail: manasranjan056@gmail.com; Bhowmik, R. N. [Department of Physics, Pondicherry University, R.Venkataraman Nagar, Kalapet, Pondicherry-605014 (India); Sinha, A. K. [Indus Synchrotrons Utilization Division, Raja Ramanna Centre for Advanced Technology, Indore-452013 (India)

    2015-06-24

    The Co{sub 2.25}Fe{sub 0.75}O{sub 4} ferrite composition has been prepared by chemical co-precipitation route. The as-prepared sample after annealing at 900°C in air formed single phase cubic spinel structure. Synchrotron X-ray diffraction and X-ray absorption near edge structure (XANES) measurements were used to study charge states of the cations in octahedral and tetrahedral sites of the cubic spinel structure. Raman spectra indicated normal cubic spinel structure. XANES data suggested the existence of Fe{sup 4+} ions in the spinel structure.

  15. Growth of ∼5 cm2V−1s−1 mobility, p-type Copper(I oxide (Cu2O films by fast atmospheric atomic layer deposition (AALD at 225°C and below

    Directory of Open Access Journals (Sweden)

    D. Muñoz-Rojas

    2012-12-01

    Full Text Available Phase pure, dense Cu2O thin films were grown on glass and polymer substrates at 225°C by rapid atmospheric atomic layer deposition (AALD. Carrier mobilities of 5 cm2V−1s−1 and carrier concentrations of ∼1016 cm−3 were achieved in films of thickness 50 - 120 nm, over a >10 cm2 area. Growth rates were ∼1 nm·min−1 which is two orders of magnitude faster than conventional ALD.. The high mobilities achieved using the atmospheric, low temperature method represent a significant advance for flextronics and flexible solar cells which require growth on plastic substrates.

  16. Preconcentration and determination of Ce, La and Pr by x-ray fluorescence analysis, using amberlite XAD resins loaded with 8-quinolinol and 2-(2-(5 chloropyridylazo)-5-dimethylamino)-phenol

    Energy Technology Data Exchange (ETDEWEB)

    Masi, A.N.; Olsina, R.A. (National Univ. of San Luis (Argentina). Dept. of Analytical Chemistry)

    1993-06-01

    8-Quinolinol (oxine) and 2-(2-(5 chloropyridylazo)-5-dimethylamino)-phenol (5ClDMPAP) were immobilized on the non ionic sorbents Amberlite XAD-4 and XAD-7. These loaded resins were used for the preconcentration of Ce, La and Pr. High preconcentration factors were obtained in each case. After the retention of these rare earths, the resins were measured as thin films by X-ray fluorescence spectrometry. Up to 50 ppm of REEs can be retained on these thin films. (Author).

  17. Effect of Ce on the structure and hydrogen storage properties of V{sub 55}Ti{sub 22.5}Cr{sub 16.1}Fe{sub 6.4}

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Yigang [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China); Chen, Yungui [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China)]. E-mail: ygchen60@yahoo.com.cn; Liang, Hao [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China); Zhou, Xiaoxiao [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China); Wu, Chaoling [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China); Tao, Mingda [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China)

    2007-02-21

    In this paper, the effect of rare metal element Ce on the microstructure, activation performance and hydrogen storage properties of V{sub 55}Ti{sub 22.5}Cr{sub 16.1}Fe{sub 6.4} BCC alloy were researched by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS) and pressure-composition-temperature (PCT) measurements. An obvious segregation of Ce happens in the Ce-containing alloys, and the addition of Ce did not change the structure of BCC alloy and the lattice parameter. The activation performance of V{sub 55}Ti{sub 22.5}Cr{sub 16.1}Fe{sub 6.4} is improved greatly by the addition of Ce. The Ce-free alloy cannot absorb hydrogen without being activated under a high temperature, but all Ce-containing alloys can absorb hydrogen rapidly at room-temperature. The absorption and desorption hydrogen capacities and the plateau pressures have no evident change when Ce content increases. Both Ce and CeO{sub 2} were found in the Ce-containing alloys. It was due to the high activation property of Ce, which can react with hydrogen, that the Ce-containing alloys are activated rapidly.

  18. Embracing a vision of the New Jerusalem (Rv 21:1−22:5 to impact on life and society

    Directory of Open Access Journals (Sweden)

    Martin H. Pohlmann

    2015-03-01

    Full Text Available Apocalyptic biblical literature has played a significant role in motivating and mobilising Christians. As part of this genre, the Apocalypse of John has played this mobilising role within the church throughout its history. Jerusalem is often incorporated into this genre to conjure up different emotions and images to impact many different people. For example, the Jew annually recites the words to fellow Jews at every Passover meal: ‘Next year in Jerusalem’. Most Christians know the hymn ‘The holy city’, originally penned by Frederic Weatherly in 1892. It lifts many a spirit as it conjures up the idea of a beautiful, perfect, heavenly city of God. However, there is more to this apocalyptic vision, which will be explored in this article. The city upholds the hope of decent godly living today. Whilst Jerusalem is a city with an extremely chequered history, it remains to be the launching pad of a dream that believers can embrace in order to impact society for the better. The vision in Revelation 21–22 is the launch of the ‘idea’ of God’s intention for society today, and the ‘implementation impetus’ is the primary role of the church. In the greater scheme of things, the world community is the target group for a better society for everyone.Aanneming van ’n visioen van die Nuwe Jerusalem (Op 21:1–22:5 ten einde ’n invloed op lewe en die samelewing uit te oefen. Apokaliptiese Bybelliteratuur het ’n beduidende rol in die motivering en aansporing van Christengemeenskappe gespeel. Die Openbaring van Johannes het hierdie motiveringsrol deurgaans in die geskiedenis van die kerkas deel van dié genre vertolk. Jerusalem is dikwels hierby ingesluit om ’n verskeidenheid van emosies en beelde op te roep ten einde ’n impak op ’n verskeidenheid mense te maak. Die Jood, byvoorbeeld, haal jaarliks die volgende woorde teenoor mede-Jode tydens die Paasmaaltyd aan: ‘Volgende jaar in Jerusalem’. Die meeste

  19. Can CSR Relieve the Financing Constraints of Enterprises?---An Empirical Study Based on 225 Survey Samples%CSR能缓解企业融资约束吗--基于225个调查样本的实证研究

    Institute of Scientific and Technical Information of China (English)

    张胜荣

    2016-01-01

    企业社会责任(CSR)是企业在生产经营过程中要摒弃把利润作为唯一目标的发展理念,对利益相关者承担起相应的责任。本文回顾了CSR与企业融资约束关系的国内外文献,通过问卷获取了225个调查样本的数据,在对数据进行探索性因子分析、信效度分析的基础上,利用相关性分析、方差分析、回归分析对CSR表现与企业融资约束的关系进行了实证研究。结果表明:CSR表现与企业融资约束高度相关,CSR表现越好,企业融资约束程度越低,其中环境责任、股东责任、消费者责任对企业融资约束影响最大。此外,企业规模对企业融资约束没有显著影响,所有制性质与企业融资约束显著相关,国有企业融资约束要远远低于民营企业。因此,企业要增强CSR意识,提高履行CSR的能力和技巧;政府要加强对CSR行为的监督和引导,加大金融对民营企业的支持力度。%Corporate social responsibility (CSR) is that the enterprise must abandon the idea that the profit is the only goal of the development in the process of production and management, and should bear the corresponding responsibility for the stakeholders. The paper reviews the domestic and foreign literatures about the relationship between CSR and financing constraints of corporate, and obtains the data from 225 survey samples by questionnaire. On the basis of exploratory factor analysis, reliability and validity analysis, using correlation analysis, variance analysis, regression analysis, the paper makes an empirical study on the relationship between CSR performance and financing constraints. The results show that CSR performance and financing constraints are highly correlated, the better CSR performance, the lower the degree of financing constraints, in particular, environmental responsibility, shareholder responsibility and consumer responsibility place the greatest impact on financing

  20. An Investigation of Osteoporosis and Related Risk Factors Among 225 Elderly People in Jinzhou%锦州市225名老年人骨质疏松相关症状及危险因素的调查分析

    Institute of Scientific and Technical Information of China (English)

    侯璇; 吴巧凤; 金炜婷; 刘堃

    2014-01-01

    目的:调查锦州市社区患有骨质疏松的老年人群中出现骨质疏松相关症状及其危险因素情况,为社区老年人骨质疏松的预防提供依据。方法采用自行设计的问卷对锦州市225名60周岁及以上患有骨质疏松的社区老年人进行调查,并利用 SPSS 17.0软件进行数据的录入和分析。结果锦州市225名社区老年人中,髋部疼痛13人(5.8%);背疼25人(11.1%);腰疼70人(31.1%);腿疼63人(28.0%);关节疼痛39人(17.3%);脆性骨折20人(8.9%);驼背31人(13.8%);身长缩短93人(41.3%)。晒太阳30分钟及以上的有212人(94.2%);体育锻炼每周3次及以上的有201人(89.3%);静坐时间6 h 以上的有29人(12.9%);补钙(24.4%)和补充维生素 D (16.9%)者较少。各年龄段中饮酒者和味重饮食者以60岁~年龄段居多,补钙者以75岁~和≥80岁最多;饮浓茶、吸烟、饮酒、静坐时间6 h 以上男性多于女性。喝浓茶、吸烟、饮酒、味重饮食、每天晒太阳30 min 以下、体育锻炼每周3次以下、静坐时间长、有激素用药史为危险因素,喜食豆制品、每天晒太阳30 min 以上、体育锻炼每周3次及以上为保护因素。结论避免骨质疏松危险因素,及早采取预防措施对阻止骨质疏松引发相关疾病具有重要意义。%Objective To investigate risk factors and symptoms of osteoporosis among elderly people in communities in the city of Jinzhou, providing preventive measure. Methods A questionnaire survey was carried out among 225 elderly people with osteoporosis who were above 60 years old and lived in communities of Jinzhou City. Data were analyzed by SPSS 17. 0. Results There were 13 people (5. 8% ) with a hip pain, 25 (11. 1% ) with back pain, 70 (31. 1% ) with low back pain, 63 (28. 0% ) with leg pain, 39 (17. 3% ) with joint pain, 20 (8. 9% ) with brittle fracture, 31 (13. 8% ) with hunchback and 93 (41. 3% ) with length shortening. 212 (94. 2% ) people

  1. Third-Order Elastic Constants and Anharmonic Properties of the Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 Bulk Metallic Glass

    Institute of Scientific and Technical Information of China (English)

    WANG Ru-Ju; LI Feng-Ying; QIN Zhi-Cheng; WANG Wei-Hua

    2001-01-01

    The longitudinal velocity V1 and shear velocity Vs of an ultrasonic wave propagated along three arbitrary perpendicular directions of the Zr41.2 Ti13.8Cu12.5Ni10.0Be22.5 bulk metallic glass (Zr/Ti BMG) have been measured at ambient pressure, under hydrostatic pressure (up to 0.5 GPa) and uniaxial compression (up to 70 MPa) using the pulse echo overlap method. The third-order elastic constants and the Gruneisen parameter related to the anharmonic properties were derived and discussed. It was found that the BMG with marked different microstructural characteristics, compared with the amorphous carbon, exhibited different behaviours related to shear vibratory under high pressure.

  2. Measurement of Inclusive ep Cross Sections at High Q2 at sqrt(s) = 225 and 252 GeV and of the Longitudinal Proton Structure Function FL at HERA

    CERN Document Server

    Andreev, V.; Baghdasaryan, S.; Begzsuren, K.; Belousov, A.; Belov, P.; Boudry, V.; Brandt, G.; Brinkmann, M.; Brisson, V.; Britzger, D.; Buniatyan, A.; Bylinkin, A.; Bystritskaya, L.; Campbell, A.J.; Cantun Avila, K.B.; Ceccopieri, F.; Cerny, K.; Chekelian, V.; Contreras, J.G.; Dainton, J.B.; Daum, K.; De Wolf, E.A.; Diaconu, C.; Dobre, M.; Dodonov, V.; Dossanov, A.; Dubak, A.; Eckerlin, G.; Egli, S.; Elsen, E.; Favart, L.; Fedotov, A.; Feltesse, J.; Ferencei, J.; Fleischer, M.; Fomenko, A.; Gabathuler, E.; Gayler, J.; Ghazaryan, S.; Glazov, A.; Goerlich, L.; Gogitidze, N.; Gouzevitch, M.; Grab, C.; Grebenyuk, A.; Greenshaw, T.; Grindhammer, G.; Habib, S.; Haidt, D.; Henderson, R.C.W.; Herbst, M.; Hildebrandt, M.; Hladky, J.; Hoffmann, D.; Horisberger, R.; Hreus, T.; Huber, F.; Jacquet, M.; Janssen, X.; Jung, A.W.; Jung, H.; Kapichine, M.; Kiesling, C.; Klein, M.; Kleinwort, C.; Kogler, R.; Kostka, P.; Kretzschmar, J.; Kruger, K.; Landon, M.P.J.; Lange, W.; Laycock, P.; Lebedev, A.; Levonian, S.; Lipka, K.; List, B.; List, J.; Lobodzinski, B.; Lubimov, V.; Malinovski, E.; Martyn, H.U.; Maxfield, S.J.; Mehta, A.; Meyer, A.B.; Meyer, H.; Meyer, J.; Mikocki, S.; Morozov, A.; Muller, K.; Naumann, Th.; Newman, P.R.; Niebuhr, C.; Nowak, G.; Nowak, K.; Olivier, B.; Olsson, J.E.; Ozerov, D.; Pahl, P.; Pascaud, C.; Patel, G.D.; Perez, E.; Petrukhin, A.; Picuric, I.; Pirumov, H.; Pitzl, D.; Placakyte, R.; Pokorny, B.; Polifka, R.; Radescu, V.; Raicevic, N.; Raspereza, A.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Rusakov, S.; Salek, D.; Sankey, D.P.C.; Sauter, M.; Sauvan, E.; Schmitt, S.; Schoeffel, L.; Schoning, A.; Schultz-Coulon, H.C.; Sefkow, F.; Shushkevich, S.; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, A.; Steder, M.; Stella, B.; Straumann, U.; Sykora, T.; Thompson, P.D.; Traynor, D.; Truol, P.; Tsakov, I.; Tseepeldorj, B.; Turnau, J.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vazdik, Y.; Wegener, D.; Wunsch, E.; Zacek, J.; Zhang, Z.; Zlebcik, R.; Zohrabyan, H.; Zomer, F.

    2014-01-01

    Inclusive ep double differential cross sections for neutral current deep inelastic scattering are measured with the H1 detector at HERA. The data were taken with a lepton beam energy of 27.6 GeV and two proton beam energies of Ep = 460 and 575 GeV corresponding to centre-of-mass energies of 225 and 252 GeV, respectively. The measurements cover the region of 6.5 *10^{-4}<=x<= 0.65 for 35<=Q^2<=800 GeV^2 up to y = 0.85. The measurements are used together with previously published H1 data at Ep = 920 GeV and lower Q2 data at Ep = 460, 575 and 920 GeV to extract the longitudinal proton structure function FL in the region 1.5<=Q^2 <=800 GeV^2.

  3. 50GeSe2-25In2Se3-25CsI glass doped with Tm3+, Tm3+/Ho3+ and Tm3+/Er3+ for amplifiers working at 1.22 μm

    Institute of Scientific and Technical Information of China (English)

    XIONG Huihua; TANG Gao; LUO Lan; CHEN Wei

    2011-01-01

    Se-based chalcohalide glass of 50GeSe2-25In2Se3-25CsI was prepared.The thermal and optical characterizations revealed that this host was thermally and optically superior for practical applications.Strong emission centered at 1.22 μm was observed in all Tm3+ single-doped,Tm3+/Ho3+ and Tm3+/Er3+ co-doped samples with an excitation of 808 nm wavelength.The emission was attributed to the Tm3+:3H5→3H6 transition.The co-doping of Ho3+ or Er3+ largely broadened the width and slightly strengthened the intensity of the 1.22 μm emission.The possible energy transfer processes and luminescence kinetics were figured.In addition,its potential application as the host material for novel optical amplifiers was discussed.

  4. Ozone decline and its effect on night airglow intensity of Na 5893°A at Dumdum (22.5°N, 88.5° E) and Halley Bay (76°S, 27°W)

    Indian Academy of Sciences (India)

    P K Jana; S C Nandi

    2006-10-01

    The paper presents the effect of O3 depletion on night airglow emission of Na 5893 A line at Dumdum (22.5°N, 88.5°E), India and Halley Bay (76°S, 27°W), a British Antarctic service station. Calculations based on chemical kinetics show that the airglow intensity of Na 5893 A line will also be affected due to the depletion of O3 concentration. The nature of yearly variation and seasonal variation of the intensity of Na 5893 A line for the above two stations are shown and compared. It is shown that the rate of decrease of intensity of Na 5893 A line is comparatively more at Halley Bay due to the dramatic decrease of Antarctic O3 concentration. A possible explanation for this dramatic decrease of Antarctic O3 concentration is also mentioned.

  5. Estudio del comportamiento del acero 2.25Cr-1Mo frente a los fenómenos de oxidación cíclica e isoterma

    Directory of Open Access Journals (Sweden)

    Proy, Manuel

    2014-03-01

    Full Text Available Cyclic and isothermal oxidation of chromium-molybdenum steel 2.25Cr-1Mo were analyzed at 550 °C and 650 °C during 360 hours in air atmospheres. The cycles were performed with two stages; one of heating in furnace during 90 minutes and then the sample were cooled to 50 °C by air flow. Thermogravimetric analyses were performed to obtain high temperature corrosion kinetics. Several characterization techniques have been used to identify the corrosion mechanism, as X-Ray Diffraction (XRD, Optical Microscopy (OM and Scanning Electron Microscopy (SEM. Thermal cycling tests can changes the corrosion mechanism, due cracks propagation in oxide scale, that witch can favors the access of oxidant agent to the substrate.La resistencia del acero aleado con cromo y molibdeno 2.25Cr-1Mo frente a la oxidación isotérmica y cíclica, fue evaluada a 550 °C y 650 °C durante 360 horas en aire. Los ciclos consistieron en el mantenimiento durante 90 minutos dentro del horno a la temperatura de ensayo y un periodo de enfriamiento forzado hasta 50 °C mediante la aplicación de un flujo de aire. Se realizó un estudio termogravimétrico para calcular las cinéticas de oxidación. Para conocer el mecanismo de degradación, se emplearon diversas técnicas de caracterización microestructural, como Difracción de Rayos (DRX, Microscopía Óptica (MO y Electrónica de Barrido (MEB. El ciclado térmico cambia el mecanismo de degradación, debido a la propagación de grietas en la película de óxido formada, que favorece el acceso del agente agresivo al sustrato.

  6. 恩施地区儿童癫痫诊治及管理存在的问题(附225例分析)%Issues in Diagnosis, Treatment and Management of Epileptic Children in Enshi (A Retrospective Study of 225 Cases)

    Institute of Scientific and Technical Information of China (English)

    杨倩; 王芳

    2015-01-01

    目的:了解恩施地区儿童癫痫诊治及管理中存在的问题,以提高儿童癫痫的诊治水平。方法对2011年1—12月在我院儿科以癫痫收治患儿225例的诊治情况、癫痫综合征分类、随访及预后情况进行回顾性分析。结果本组中142例(63.1%)曾在外院诊断为癫痫,仅5例(3.5%)进行癫痫综合征分类;46例(32.4%)误漏诊,其中22例癫痫误诊为其他疾病,24例非癫痫误诊为癫痫。116例(81.7%)首诊治疗不正规,92例首次治疗使用2种抗癫痫药物(AEDs),其中农村患儿84例,24例用药剂量不足。来我院后,确诊癫痫201例,仅21例(10.4%)不能进行综合征归类,余180例均按照2010年国际抗癫痫联盟的癫痫分类诊断标准进行分型诊断,22例(10.9%)暂未应用AEDs 治疗,单一AEDs 治疗135例(67.2%),联用2种AEDs 治疗33例(16.4%),联用3种AEDs 治疗11例(5.5%)。随访率79.6%,服药1年内112例(55.7%)擅自减量或停药,农村患儿占44.3%。经治疗症状完全控制121例(60.2%),显效及有效59例(29.4%),无效21例(10.4%)。另24例经相关检查排除癫痫诊断,10例脑性瘫痪治疗后症状好转,余14例治愈。结论对于儿童癫痫的诊断,首先要确定发作类型,再明确癫痫综合征分类,然后按照规范、个体化原则选择疗效确切、依从性好的AEDs 进行治疗。尤其要加强农村癫痫患儿治疗期间的随访跟踪管理。%Objective To discuss diagnosis, treatment and management of epileptic children in Enshi in order to im-prove the levels of diagnosis and treatment. Methods A Retrospective analysis of diagnosis and treatment, classifications and prognosis were made on 225 cases of epileptic children in the department of pediatrics of our hospital during January and De-cember 2011. Results 142 cases (63. 1%) were diagnosed as epilepsy in other hospitals and only 5 cases (3. 5%) were classified as epilepsy syndrome;46 cases (32. 4%) were misdiagnosed, among which, 22 epileptic children

  7. Influence of propane content on thermal shock property of TiB2-25Ni coating sprayed by high velocity oxygen fuel%丙烷流量对超音速火焰喷涂TiB2-25Ni涂层抗热震性能的影响

    Institute of Scientific and Technical Information of China (English)

    陈枭; 王洪涛; 纪岗昌; 白小波; 张琳

    2016-01-01

    Different coatings were prepared on Q235 steel substrate surface used mechanical milling TiB2-25Ni particles as raw materials by high velocity oxygen fuel (HVOF) under three kinds of propane flows(30,36 and 42 L/min),the thermal shock property of the coatings at 600 ℃ (50 cycles,100 cycles and 150 cycles) and 800 ℃ was tested.The surface and cross-sectional morphology of the coatings after thermal shock test were studied by scanning electron microscopy (SEM) to analyze the crack generation and propagation,and the composition transformation of the coatings was analyzed by X-ray diffraction analysis (XRD).The results show that with increasing the thermal shock cycles,the propagating cracks of the three kinds of the coatings are worse at 600 ℃,and there are longitudinal and transverse cracks appeare in the coatings,especially the coating with propane flow rate of 36 L/min is the worst among the three coatings.The thermal shock cycles are obviously decreased and the coatings are invalid faster under 800 ℃ conditions,meanwhile,there are a network of cracks appear on the surface of the coatings,and the cracks propagate into the interface of the coating and substrate,it can lead to the substrate corroded by the corrosion medium (i.e.water,air) to form metallic oxide.By investigating the phase composition of the three coatings after thermal shock,the main composition of the coatings is TiB2 and Ni,and the metallic oxides increase after thermal shock test.%采用超音速火焰喷涂技术(HVOF)在3种丙烷流量(30,36和42 L/min)下将机械球磨后的TiB2-25 Ni颗粒沉积在Q235钢表面上获得不同涂层,将涂层在600℃(50次、100次、150次)和800℃工况下进行热震试验,研究涂层的抗热震性能.采用扫描电镜(SEM)表征热震后涂层的表面和截面形貌以分析热震后的裂纹产生和扩展情况,通过X射线衍射技术(XRD)分析热震后涂层的物相演变规律.研究结果发现,3种涂层在600℃热震条件下随

  8. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  9. Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells.

    Science.gov (United States)

    Tripathi, Shubhandra; Srivastava, Gaurava; Sharma, Ashok

    2016-08-05

    Drug resistance poses a threatening challenge for mankind, as the development of resistance to already well-established drugs causes serious therapeutic problems. Resistance to paclitaxel (Ptxl), a complex diterpenoid working as microtubule stabilizer, is one such issue in cancer treatment. Microtubule stabilizer drugs, stabilises microtubules upon binding to β-tubulin subunit of tubulin heterodimer thus causing mitotic arrest leading to death of cancer cell. Leucine point mutations viz. L215H, L217R, and L225M were reported for Ptxl resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations was explored using molecular docking, molecular dynamics (MD) simulation, binding energy estimation (MMPBSA), free energy decomposition, principle component analysis (PCA) and free energy landscape (FEL) methods. A total of five systems including unbound βI-tubulin (Apo), docked wild+Ptxl, L215H+Ptxl, L217R+Ptxl and L225M+Ptxl were prepared, and 50 ns MD simulation was performed for each system. Binding energy estimation indicated that leucine mutation reduces the binding affinity of Ptxl in mutant types (MTs) as compared to wild type (WT). Further, in contrast to WT Ptxl interactions with the M-loop (PHE270-VAL286), S6-S7 loop and H9-H10 were significantly altered in MTs. Results showed that in MTs, Ptxl had weak interaction with M-loop residues, while having strong affinity with S6-S7 loop and H6-H7 loop. Moreover, PCA and FEL analysis revealed that M-loop flexible region (THR274-LEU284) was strongly bound with Ptxl in WT preventing its flexible movement and the causing factor for microtubule stabilization. In MTs due to poor interaction with Ptxl, M-loop flexible region retains its flexibility, therefore unable to stabilize microtubule. This study will give an insight into the importance of M-loop flexible region interaction with Ptxl for microtubule stabilization. In addition, it clearly provides the molecular basis of

  10. 麻醉和镇静术在225例无痛结肠镜检查中的临床分析%Comparison of Anesthesia and Conscious Sedation on Colonial Endoscopy in 255 Cases

    Institute of Scientific and Technical Information of China (English)

    张清; 郭爱华; 黄鹿; 王剑波

    2012-01-01

    Objective This study was to compare the safety and efficacy of anesthesia or conscious sedation on colonial endoscopy examination. Method Totally,225 patients who accepted colonial endoscopy examination were invoved in the stud-y. The patients randomly accepted anesthesia ( Ⅱ group) or conscious sedation( I group) before the colonial endoscopy. The change of blood pressure (BP), heart rate ( HR), oxygen saturation (SPO2) and murmuring were investigated during the examination. The adverse event after the examination was also followed. Results (1) The patients in Ⅱ group showed lower incidence rate of murmuring than that in I group. (2)The patients in I group showed lower incidence rate of BP and HR decrease than that in Ⅱ group. (3) Both group showed no severe adverse event during and after the colonial endoscopy examination. Conclusion Both anesthesia and conscious sedation are safe and can be used in colonial endoscopy examination effective- ly.%目的 比较麻醉和镇静术对接受结肠镜检查患者的安全性及治疗效果.方法 225例于我院行结肠镜检查的患者,随机接受丙泊酚伍用芬太尼麻醉或咪唑安定清醒镇静诊疗,比较两组患者结肠镜检查过程中血压、心率、血氧饱和度变化情况及呻吟、肢动等不良反应,并追踪观察患者术后清醒时间及不良事件的发生率.结果 麻醉组患者呻吟、肢动发生率显著低于清醒镇静组;清醒镇静组血压、心率、血氧饱和度下降显著低于麻醉组.两组患者给药时间、术中及术后不良事件的发生率无显著差异.结论 麻醉及清醒镇静术均可有效缓解结肠镜检查所致的不良反应,无严重不良事件发生.

  11. Structural phase change in Co{sub 2.25}Fe{sub 0.75}O{sub 4} spinel oxide by vacuum annealing and role of coexisting CoO phase on magnetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Bhowmik, R.N., E-mail: rnbhowmik.phy@pondiuni.edu.in [Department of Physics, Pondicherry University, R.V. Nagar, Kalapet, Pondicherry 605014 (India); Panda, Manas Ranjan [Department of Physics, Pondicherry University, R.V. Nagar, Kalapet, Pondicherry 605014 (India); Yusuf, S.M.; Mukadam, M.D. [Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Sinha, A.K. [Indus Synchrotrons Utilization Division, Raja Ramanna Centre for Advanced Technology, Indore 452013 (India)

    2015-10-15

    The spinel oxide Co{sub 2.25}Fe{sub 0.75}O{sub 4} has been prepared by co-precipitation route. The as prepared material has been annealed at 800 °C under vacuum. Properties of the samples annealed under vacuum have been compared with the sample annealed in air. Synchrotron X-ray diffraction, Raman spectroscopy and X-ray absorption near edge structure spectroscopy have been used for structural phase characterization. The cubic spinel structure in air annealed sample has been splitted into Co and Fe rich phases. The Co rich spinel phase has transformed into Cobalt monoxide (CoO) after vacuum annealing. This has resulted an increase of Fe:Co ratio in the Fe rich spinel phase. Raman spectra indicated a transformation of the distribution of Co and Fe ions from normal spinel like structure for the sample annealed in air to mixed spinel structure for the samples annealed under vacuum. The existence tetravalent Fe{sup 4+} ion has been confirmed in all the samples and it is new information for Co doped spinel ferrite system. All the samples exhibited ferrimagnetic behavior and exchange bias effect. The focus point is that vacuum annealing has been used as an effective route of material processing to control the structural phase and also, enhancement of magnetic properties in Co rich ferrite. - Graphical abstract: M(H) loop of vacuum annealed CoFe8V4 samples (a-e) and air annealed CoFe8A4 sample (f-g) at selected measurement temperatures. The variation of exchange bias field with temperatures for both the samples (h). - Highlights: • Structure and ferrimagnetic properties of Co{sub 2.25}Fe{sub 0.75}O{sub 4} have been reported. • Self-composite structure of material has been tailored by vacuum annealing. • Synchrotron X-ray diffraction and XANES have been used for characterization. • The existence tetravalent Fe{sup 4+} ions in ferrite structure is a new information. • The coexistence of CoO gives a great opportunity for tuning ferrimagnetic parameters.

  12. Structure of the mercury(II) mixed-halide (Br/Cl) complex of 2,2'-(5-tert-butyl-1,3-phenyl-ene)bis-(1-pentyl-1H-benzo[d]imidazole).

    Science.gov (United States)

    Rani, Varsha; Singh, Harkesh B; Butcher, Ray J

    2017-03-01

    The mercury(II) complex of 2,2'-(5-tert-butyl-1,3-phenyl-ene)bis-(1-pentyl-1H-benz-imidazole), namely catena-poly[[dihalogenido-mercury(II)]-μ-2,2'-(5-tert-butyl-1,3-phenyl-ene)bis-(1-pentyl-1H-benzimidazole)-κ(2)N(3):N(3')], [HgBr1.52Cl0.48(C34H42N4)], 2, has a polymeric structure bridging via the N atoms from the benzimidazole moieties of the ligand. The compound crystallizes in the ortho-rhom-bic space group Pca21 and is a racemic twin [BASF = 0.402 (9)]. The geometry around the Hg(II) atom is distorted tetra-hedral, with the Hg(II) atom coordinated to two N atoms, one Br atom, and a fourth coordination site is occupied by a mixed halide (Br/Cl). For the two ligands in the asymmetric unit, there is disorder with one of the two tert-butyl groups and benzimidazole moieties showing twofold disorder, with occupancy factors of 0.57 (2):0.43 (2) for the tert-butyl group and 0.73 (3):0.27 (3) for the benzimidazole group. In addition, there is threefold disorder for two of the four n-pentyl groups, with occupancy factors of 0.669 (4):0.177 (4):0.154 (4) and 0.662 (4):0.224 (4):0.154 (4), respectively. The mol-ecules form a one-dimensional helical polymer propagating in the b-axis direction. The helices are held together by intra-strand C-H⋯Br and C-H⋯Cl inter-actions. Each strand is further linked by inter-strand C-H⋯Br and C-H⋯Cl inter-actions. In addition, there are weak C-H⋯N inter-strand inter-actions which further stabilize the structural arrangement.

  13. The first Hi-GAL observations of the outer Galaxy: a look to star formation in the third Galactic quadrant in the longitude range 216.5 < l < 225.5

    CERN Document Server

    Elia, D; Fukui, Y; Schisano, E; Olmi, L; Veneziani, M; Hayakawa, T; Pestalozzi, M; Schneider, N; Benedettini, M; Di Giorgio, A M; Ikhenaode, D; Mizuno, A; Onishi, T; Pezzuto, S; Piazzo, L; Polychroni, D; Rygl, K L J; Yamamoto, H; Maruccia, Y

    2013-01-01

    We present the first Herschel PACS and SPIRE photometric observations in a portion of the outer Galaxy ($216.5^{\\circ} \\lesssim \\ell \\lesssim 225.5^{\\circ}$ and $-2^{\\circ} \\lesssim b \\lesssim 0^{\\circ}$) as a part of the Hi-GAL survey. The maps between 70 and 500 $\\mu$m, the derived column density and temperature maps, and the compact source catalog are presented. NANTEN CO(1-0) line observations are used to derive cloud kinematics and distances, so that we can estimate distance-dependent physical parameters of the compact sources (cores and clumps) having a reliable spectral energy distribution, that we separate in 255 proto-stellar and 688 starless. Both typologies are found in association with all the distance components observed in the field, up to $\\sim 5.8$ kpc, testifying the presence of star formation beyond the Perseus arm at these longitudes. Selecting the starless gravitationally bound sources we identify 590 pre-stellar candidates. Several sources of both proto- and pre-stellar nature are found t...

  14. Atomic structure of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} bulk metallic glass alloy

    Energy Technology Data Exchange (ETDEWEB)

    Hui, X. [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China)], E-mail: huixd01@hotmail.com; Fang, H.Z.; Chen, G.L. [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Shang, S.L.; Wang, Y. [Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA 16802 (United States); Qin, J.Y. [Key Laboratory of Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University - Southern Campus, Jinan 250061 (China); Liu, Z.K. [Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA 16802 (United States)

    2009-01-15

    Ab initio molecular dynamics (AIMD) calculations were performed on the atomic configuration of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} bulk metallic glass. The local structures were characterized in terms of structure factors (SF), pair correlation functions (PCF), coordinate numbers, bond pairs and Voronoi polyhedra. The glass transition temperature, generalized PCF and SF predicated by AIMD are in good agreement with the experimental data. Icosahedral short-range orders (ISRO) are found to be the most dominant, in view of the presence of the majority of bond pairs with 1551, 1541 and 1431, and Voronoi polyhedra with <0,3,6,1>, <0,2,8,1>, <0,0,12,0> and <0,2,8,4>. Icosahedral medium range orders (IMROs) are formed from icosahedra via the linkage of vertex-, edge-, face- and intercross-shared atoms. The glass structure on the nanometer scale is accumulated by polyhedra through an efficient packing mode. It is suggested that the extraordinary glass-forming ability of this alloy is essentially attributable to the formation of ISRO and IMRO, and the dense packing of atoms.

  15. Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif.

    Science.gov (United States)

    Vedula, L Sangeetha; Jiang, Jiaoyang; Zakharian, Tatiana; Cane, David E; Christianson, David W

    2008-01-15

    Trichodiene synthase from Fusarium sporotrichioides contains two metal ion-binding motifs required for the cyclization of farnesyl diphosphate: the "aspartate-rich" motif D(100)DXX(D/E) that coordinates to Mg2+A and Mg2+C, and the "NSE/DTE" motif N(225)DXXSXXXE that chelates Mg2+B (boldface indicates metal ion ligands). Here, we report steady-state kinetic parameters, product array analyses, and X-ray crystal structures of trichodiene synthase mutants in which the fungal NSE motif is progressively converted into a plant-like DDXXTXXXE motif, resulting in a degradation in both steady-state kinetic parameters and product specificity. Each catalytically active mutant generates a different distribution of sesquiterpene products, and three newly detected sesquiterpenes are identified. In addition, the kinetic and structural properties of the Y295F mutant of trichodiene synthase were found to be similar to those of the wild-type enzyme, thereby ruling out a proposed role for Y295 in catalysis.

  16. Homogeneous Plastic Flow of Fully Amorphous and Partially Crystallized Zr41.2Ti13.8Cu12.5Ni10Be22.5 Bulk Metallic Glass

    Institute of Scientific and Technical Information of China (English)

    Q.WANG; J.J. Blandin; M. Suery; B. Van de Moortéle; J.M. Pelletier

    2003-01-01

    The homogeneous plastic flow of fully amorphous and partially crystallized Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass (Vit1) has been investigated by compression tests at high temperatures in supercooled liquid region. Experimental results show that at sufficiently low strain rates, the supercooled liquid of the fully amorphous alloy reveals Newtonian flow with a linear relationship between the flow stress and strain rate. As the strain rate is increased, a transition from linear Newtonian to nonlinear flow is detected, which can be explained by the transition state theory.Over the entire strain rate interval investigated, however, only nonlinear flow is present in the partially crystallized alloy, and the flow stress for each strain rate is much higher. It is found that the strain rate-stress relationship for the partially crystallized alloy at the given temperature of 646 K also obeys the sinh law derived from the transition state theory, similar to that of the initial homogeneous amorphous alloy. Thus, it is proposed that the flow behavior of the nanocrystalline/amorphous composite at 646 K is mainly controlled by the viscous flow of the remaining supercooled liquid.

  17. Measurement of inclusive ep cross sections at high Q{sup 2} at √(s) = 225 and 252 GeV and of the longitudinal proton structure function F{sub L} at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Andreev, V.; Belousov, A.; Fomenko, A.; Gogitidze, N.; Lebedev, A.; Malinovski, E.; Rusakov, S.; Vazdik, Y. [Lebedev Physical Institute, Moscow (Russian Federation); Baghdasaryan, A.; Baghdasaryan, S.; Zohrabyan, H. [Yerevan Physics Institute, Yerevan (Armenia); Begzsuren, K.; Ravdandorj, T.; Tseepeldorj, B. [Institute of Physics and Technology of the Mongolian Academy of Sciences, Ulaanbaatar (Mongolia); Belov, P.; Brinkmann, M.; Britzger, D.; Campbell, A.J.; Dodonov, V.; Eckerlin, G.; Elsen, E.; Fleischer, M.; Gayler, J.; Ghazaryan, S.; Glazov, A.; Gouzevitch, M.; Grebenyuk, A.; Habib, S.; Haidt, D.; Kleinwort, C.; Krueger, K.; Levonian, S.; Lipka, K.; List, B.; List, J.; Lobodzinski, B.; Meyer, A.B.; Meyer, J.; Niebuhr, C.; Olsson, J.E.; Ozerov, D.; Pahl, P.; Petrukhin, A.; Pirumov, H.; Pitzl, D.; Placakyte, R.; Radescu, V.; Raspereza, A.; Schmitt, S.; Sefkow, F.; Shushkevich, S.; South, D.; Steder, M.; Wuensch, E. [DESY, Hamburg (Germany); Boudry, V.; Specka, A. [LLR, Ecole Polytechnique, CNRS/IN2P3, Palaiseau (France); Bradt, G. [Oxford University, Department of Physics, Oxford (United Kingdom); Brisson, V.; Jacquet, M.; Pascaud, C.; Zhang, Z.; Zomer, F. [LAL, Universite Paris-Sud, CNRS/IN2P3, Orsay (France); Buniatyan, A.; Huber, F.; Sauter, M.; Schoening, A. [Universitaet Heidelberg, Physikalisches Institut, Heidelberg (Germany); Bylinkin, A.; Bystritskaya, L.; Fedotov, A.; Rostovtsev, A. [Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Cantun Avila, K.B.; Contreras, J.G. [CINVESTAV, Departamento de Fisica Aplicada, Merida, Yucatan (Mexico); Ceccopieri, F.; Wolf, E.A. de; Favart, L.; Hreus, T.; Janssen, X.; Roosen, R.; Mechelen, P. van [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (Belgium); Cerny, K.; Pokorny, B.; Polifka, R.; Salek, D.; Valkarova, A.; Zacek, J.; Zlebcik, R. [Charles University, Faculty of Mathematics and Physics, Prague (Czech Republic); Chekelian, V.; Grindhammer, G.; Kiesling, C.; Olivier, B. [Max-Planck-Institut fuer Physik, Munich (Germany); Dainton, J.B.; Gabathuler, E.; Greenshaw, T.; Klein, M.; Kretzschmar, J.; Laycock, P.; Maxfield, S.J.; Mehta, A.; Patel, G.D. [University of Liverpool, Department of Physics, Liverpool (United Kingdom); Daum, K.; Meyer, H. [Universitaet Wuppertal, Fachbereich C, Wuppertal (Germany); Diaconu, C.; Hoffmann, D.; Sauvan, E.; Vallee, C. [CPPM, Aix-Marseille Univ, CNRS/IN2P3, Marseille (France); Dobre, M.; Rotaru, M. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (Romania); Dossanov, A. [Universitaet Hamburg, Institut fuer Experimentalphysik, Hamburg (Germany); Max-Planck-Institut fuer Physik, Munich (Germany); Dubak, A. [Max-Planck-Institut fuer Physik, Munich (Germany); University of Montenegro, Faculty of Science, Podgorica (Montenegro); Egli, S.; Hildebrandt, M.; Horisberger, R. [Paul Scherrer Institut, Villigen (Switzerland); Feltesse, J.; Perez, E.; Schoeffel, L. [CEA, DSM/Irfu, CE-Saclay, Gif-sur-Yvette (France); Ferencei, J. [Slovak Academy of Sciences, Institute of Experimental Physics, Kosice (Slovakia); Goerlich, L.; Mikocki, S.; Nowak, G.; Sopicki, P.; Turnau, J. [Institute for Nuclear Physics, Cracow (Poland); Grab, C. [ETH, Institut fuer Teilchenphysik, Zurich (Switzerland); Henderson, R.C.W. [University of Lancaster, Department of Physics, Lancaster (United Kingdom); Herbst, M.; Jung, A.W.; Schultz-Coulon, H.C. [Universitaet Heidelberg, Kirchhoff-Institut fuer Physik, Heidelberg (Germany); Hladka, J.; Reimer, P. [Academy of Sciences of the Czech Republic, Institute of Physics, Prague (Czech Republic); Jung, H. [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (Belgium); DESY, Hamburg (Germany); Kapichine, M.; Morozov, A.; Spaskov, V. [Joint Institute for Nuclear Research, Dubna (RU); Kogler, R.; Nowak, K. [Universitaet Hamburg, Institut fuer Experimentalphysik, Hamburg (DE); Kostka, P.; Lange, W.; Naumann, T. [DESY, Zeuthen (DE); Landon, M.P.J.; Rizvi, E.; Traynor, D. [University of London, School of Physics and Astronomy, Queen Mary, London (GB); Lubimov, V. [Institute for Theoretical and Experimental Physics, Moscow (RU); Martyn, H.U. [I. Physikalisches Institut der RWTH, Aachen (DE); Mueller, K.; Robmann, P.; Straumann, U.; Truoel, P. [Physik-Institut der Universitaet Zuerich, Zurich (CH); Newman, P.R.; Thompson, P.D. [School of Physics and Astronomy, University of Birmingham, Birmingham (GB); Picuric, I.; Raicevic, N. [University of Montenegro, Faculty of Science, Podgorica (ME); Sankey, D.P.C. [STFC, Rutherford Appleton Laboratory, Oxfordshire (GB); Soloviev, Y. [DESY, Hamburg (DE); Lebedev Physical Institute, Moscow (RU); Stella, B. [Universita di Roma Tre (IT); INFN Roma 3, Dipartimento di Fisica, Rome (IT); Sykora, T. [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (BE); Charles University, Faculty of Mathematics and Physics, Prague (CZ); Tsakov, I. [Institute for Nuclear Research and Nuclear Energy, Sofia (BG); Wegener, D. [Institut fuer Physik, TU Dortmund, Dortmund (DE); Collaboration: H1 Collaboration

    2014-04-15

    Inclusive ep double differential cross sections for neutral current deep inelastic scattering are measured with the H1 detector at HERA.The data were taken with a lepton beam energy of 27.6 GeV and two proton beam energies of E{sub p} = 460 and 575 GeV corresponding to centre-of-mass energies of 225 and 252 GeV, respectively. The measurements cover the region of 6.5 x 10{sup -4} ≤ x ≤ 0.65 for 35 ≤ Q{sup 2} ≤ 800 GeV{sup 2} up to y = 0.85. The measurements are used together with previously published H1 data at E{sub p} = 920 GeV and lower Q{sup 2} data at E{sub p} = 460, 575 and 920 GeV to extract the longitudinal proton structure function F{sub L} in the region 1.5 ≤ Q{sup 2} ≤ 800 GeV{sup 2}. (orig.)

  18. Demonstration of 575-Mb/s downlink and 225-Mb/s uplink bi-directional SCM-WDM visible light communication using RGB LED and phosphor-based LED.

    Science.gov (United States)

    Wang, Yuanquan; Wang, Yiguang; Chi, Nan; Yu, Jianjun; Shang, Huiliang

    2013-01-14

    We propose and experimentally demonstrate a novel full-duplex bi-directional subcarrier multiplexing (SCM)-wavelength division multiplexing (WDM) visible light communication (VLC) system based on commercially available red-green-blue (RGB) light emitting diode (LED) and phosphor-based LED (P-LED) with 575-Mb/s downstream and 225-Mb/s upstream transmission, employing various modulation orders of quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM). For the downlink, red and green colors/wavelengths are assigned to carry useful information, while blue chip is just kept lighting to maintain the white color illumination, and for the uplink, the low-cost P-LED is implemented. In this demonstration, pre-equalization and post-equalization are also adopted to compensate the severe frequency response of LEDs. Using this scheme, 4-user downlink and 1-user uplink transmission can be achieved. Furthermore, it can support more users by adjusting the bandwidth of each sub-channel. Bit error rates (BERs) of all links are below pre-forward-error-correction (pre-FEC) threshold of 3.8x 10(-3) after 66-cm free-space delivery. The results show that this scheme has great potential in the practical VLC system.

  19. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the R/V Meteor Cruise 22/5 in the South Atlantic Ocean (WOCE Section A10, December 1992-January 1993)

    Energy Technology Data Exchange (ETDEWEB)

    Kozyr, A.

    1998-12-01

    This data documentation discusses the procedures and methods used to measure total carbon dioxide (TCO{sub 2}) and total alkalinity (TALK) at hydrographic stations, as well as the underway partial pressure of CO{sub 2} (pCO{sub 2}) during the R/V Meteor Cruise 22/5 in the South Atlantic Ocean (Section A10). Conducted as part of the World Ocean Circulation Experiment (WOCE), the cruise began in Rio de Janeiro on December 27, 1992, and ended after 36 days at sea in Capetown, South Africa, on January 31, 1993. Measurements made along WOCE Section A10 included pressure, temperature, and salinity [measured by conductivity, temperature, and depth (CTD) sensor], bottle salinity, bottle oxygen, phosphate, nitrate, nitrite, silicate, chlorofluorocarbons (CFC-1 1 , CFC-12), TCO{sub 2}, TALK, and underway pCO{sub 2}. The TCO{sub 2} was measured by using two Single-Operator Multiparameter Metabolic Analyzers (SOMMAs) for extracting CO{sub 2} from seawater samples that were coupled to a coulometer for detection of the extracted CO{sub 2}. The overall precision and accuracy of the analyses was {+-} 1.9 {micro}mol/kg. Samples collected for TALK were measured by potentiometric titration; precision was {+-}2.0 {micro}mol/kg. Underway pCO{sub 2} was measured by infrared photometry with a precision of {+-} 2.0 {micro}atm. The work aboard the R/V Meteor was supported by the U.S. Department of Energy under contract DE-AC02-76CHOO016, and the Bundesministerium fir Forschung und Technologies through grants 03F0545A and MPG 099/1.

  20. Carbon dioxide, hydrographic, and chemical data obtained during the R/V Meteor Cruise 22/5 in the South Atlantic Ocean (WOCE Section A10, December 1992--January 1993)

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, K.M.; Wallace, D.W.R. [Brookhaven National Lab., Upton, NY (United States). Oceanographic and Atmospheric Sciences Div.; Schneider, B. [Inst. fuer Ostseeforschung, Rostock-Warnemuende (Germany); Mintrop, L. [Univ. of Bremen (Germany). Dept. of Geosciences

    1997-04-01

    This documentation discusses the procedures and methods used to measure total carbon dioxide (TCO{sub 2}), total alkalinity at Hydrographic stations as well as the underway partial pressure of CO{sub 2} (pCO{sub 2}) during the R/V Meteor Cruise M22/5 in the South Atlantic Ocean (Section A10). Conducted as part of the World Ocean Circulation Experiment (WOCE), the cruise began in Rio de Janeiro on 27 December 1992, and ended after 36 days at sea in Capetown, South Africa on 31 January 1993. Instructions for accessing the data are provided. TCO{sub 2} was measured using tow automated sample processors for extracting CO{sub 2} from seawater samples which were coupled to a Coulometer for detection of the extracted CO{sub 2}. The overall precision and accuracy of the analyses was {+-} 1.9 {micro}mol/kg. Samples collected for total alkalinity were measured by potentiometric titration; precision was {+-} 2.0 {micro}mol/kg. Underway pCO{sub 2} was measured by Infra Red (IR) Photometry; precision was {+-} 2.0 {micro}atm. From these cruises the large-scale three-dimensional distribution of temperature, salinity, and chemical constituents, including the carbonate system parameters will be mapped. Knowledge of these parameters and their initial conditions will allow determination of heat and water transports as well as carbon transport. An understanding of these transports will contribute to the understanding of processes which are relevant for climate change. This section in the South Atlantic subtropical Gyre is especially relevant for CO{sub 2} transport because it crosses both the Brazil and the Benguela Boundary Currents.

  1. THE FIRST Hi-GAL OBSERVATIONS OF THE OUTER GALAXY: A LOOK AT STAR FORMATION IN THE THIRD GALACTIC QUADRANT IN THE LONGITUDE RANGE 216. Degree-Sign 5 {approx}< l {approx}< 225. Degree-Sign 5

    Energy Technology Data Exchange (ETDEWEB)

    Elia, D.; Molinari, S.; Schisano, E.; Pestalozzi, M.; Benedettini, M.; Di Giorgio, A. M.; Pezzuto, S.; Rygl, K. L. J. [Istituto di Astrofisica e Planetologia Spaziali-INAF, Via Fosso del Cavaliere 100, I-00133 Roma (Italy); Fukui, Y.; Hayakawa, T.; Yamamoto, H. [Department of Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602 (Japan); Olmi, L. [Osservatorio Astrofisico di Arcetri-INAF, Largo E. Fermi 5, I-50125 Firenze (Italy); Veneziani, M. [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Schneider, N.; Piazzo, L. [IRFU/SAp CEA/DSM, Laboratoire AIM CNRS, Universit Paris Diderot, F-91191 Gif-sur-Yvette (France); Ikhenaode, D. [DIET-Dipartimento di Ingegneria dell' Informazione, Elettronica e Telecomunicazioni, Universita di Roma La Sapienza, via Eudossina 18, I-00184 Roma (Italy); Mizuno, A. [Solar-Terrestrial Environment Laboratory, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Onishi, T. [Department of Physical Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan); Polychroni, D. [Department of Astrophysics, Astronomy and Mechanics, Faculty of Physics, University of Athens, Panepistimiopolis, 15784 Zografos, Athens (Greece); Maruccia, Y., E-mail: davide.elia@iaps.inaf.it [Dipartimento di Matematica e Fisica, Universita del Salento, CP 193, I-73100 Lecce (Italy)

    2013-07-20

    We present the first Herschel PACS and SPIRE photometric observations in a portion of the outer Galaxy (216. Degree-Sign 5 {approx}< l {approx}< 225. Degree-Sign 5 and -2 Degree-Sign {approx}< b {approx}< 0 Degree-Sign ) as a part of the Hi-GAL survey. The maps between 70 and 500 {mu}m, the derived column density and temperature maps, and the compact source catalog are presented. NANTEN CO(1-0) line observations are used to derive cloud kinematics and distances so that we can estimate distance-dependent physical parameters of the compact sources (cores and clumps) having a reliable spectral energy distribution that we separate into 255 proto-stellar and 688 starless sources. Both typologies are found in association with all the distance components observed in the field, up to {approx}5.8 kpc, testifying to the presence of star formation beyond the Perseus arm at these longitudes. Selecting the starless gravitationally bound sources, we identify 590 pre-stellar candidates. Several sources of both proto- and pre-stellar nature are found to exceed the minimum requirement for being compatible with massive star formation based on the mass-radius relation. For the pre-stellar sources belonging to the Local arm (d {approx}< 1.5 kpc) we study the mass function whose high-mass end shows a power law N(log M){proportional_to}M {sup -1.0{+-}0.2}. Finally, we use a luminosity versus mass diagram to infer the evolutionary status of the sources, finding that most of the proto-stellar sources are in the early accretion phase (with some cases compatible with a Class I stage), while for pre-stellar sources, in general, accretion has not yet started.

  2. Continuous gradient temperature Raman spectroscopy of the long chain polyunsaturated fatty acids docosapentaenoic (DPA, 22:5n-6) and docosahexaenoic (DHA; 22:6n-3) from -100 to 20° C

    Science.gov (United States)

    Broadhurst, C. Leigh; Schmidt, Walter F.; Kim, Moon S.; Nguyen, Julie K.; Qin, Jianwei; Chao, Kuanglin; Bauchan, Gary L.; Shelton, Daniel R.

    2016-05-01

    The structural, cognitive and visual development of the human brain and retina strictly require long-chain polyunsaturated fatty acids (LC-PUFA). Excluding water, the mammalian brain is about 60% lipid. One of the great unanswered questions with respect to biological science in general is the absolute necessity of the LC-PUFA docosahexaenoic acid (DHA; 22:6n-3) in these fast signal processing tissues. A lipid of the same chain length with just one less diene group, docosapentaenoic acid (DPA; 22:5n-6) is fairly abundant in terrestrial food chains yet cannot substitute for DHA. Gradient Temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions. Herein we apply GTRS to DPA, and DHA from -100 to 20°C. 20 Mb three-dimensional data arrays with 1°C increments and first/second derivatives allows complete assignment of solid, liquid and transition state vibrational modes, including low intensity/frequency vibrations that cannot be readily analyzed with conventional Raman. DPA and DHA show significant spectral changes with premelting (-33 and -60°C, respectively) and melting (-27 and -44°C, respectively). The CH2-(HC=CH)-CH2 moieties are not identical in the second half of the DHA and DPA structures. The DHA molecule contains major CH2 twisting (1265 cm-1) with no noticeable CH2 bending, consistent with a flat helical structure with small pitch. Further modeling of neuronal membrane phospholipids must take into account this structure for DHA, which would be configured parallel to the hydrophilic head group line.

  3. Desirability-Based Multi-Criteria Optimization of HVOF Spray Experiments to Manufacture Fine Structured Wear-Resistant 75Cr3C2-25(NiCr20) Coatings

    Science.gov (United States)

    Tillmann, W.; Vogli, E.; Baumann, I.; Kopp, G.; Weihs, C.

    2010-01-01

    Thermal spraying of fine feedstock powders allow the deposition of cermet coatings with significantly improved characteristics and is currently of great interest in science and industry. However, due to the high surface to volume ratio and the low specific weight, fine particles are not only difficult to spray but also show a poor flowability in the feeding process. In order to process fine powders reliably and to preserve the fine structure of the feedstock material in the final coating morphology, the use of novel thermal spray equipment as well as a thorough selection and optimization of the process parameters are fundamentally required. In this study, HVOF spray experiments have been conducted to manufacture fine structured, wear-resistant cermet coatings using fine 75Cr3C2-25(Ni20Cr) powders (-8 + 2 μm). Statistical design of experiments (DOE) has been utilized to identify the most relevant process parameters with their linear, quadratic and interaction effects using Plackett-Burman, Fractional-Factorial and Central Composite designs to model the deposition efficiency of the process and the majorly important coating properties: roughness, hardness and porosity. The concept of desirability functions and the desirability index have been applied to combine these response variables in order to find a process parameter combination that yields either optimum results for all responses, or at least the best possible compromise. Verification experiments in the so found optimum obtained very satisfying or even excellent results. The coatings featured an average microhardness of 1004 HV 0.1, a roughness Ra = 1.9 μm and a porosity of 1.7%. In addition, a high deposition efficiency of 71% could be obtained.

  4. QTL Information Table: 225 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Resistance or Tolerance Blast resistance Neck blast incidence at Kampangsaen (1998)...A., Pa-In, N., Vongsaprom, C., and Toojinda, T. (2002). Quantitative Trait Loci Associated with Leaf and Neck

  5. 48 CFR 225.7102-1 - Policy.

    Science.gov (United States)

    2010-10-01

    ... items that are of domestic manufacture to the maximum extent practicable: Items Categories Ship propulsion shafts Excludes service and landing craft shafts. Periscope tubes All. Ring forgings for...

  6. 48 CFR 225.7002-2 - Exceptions.

    Science.gov (United States)

    2010-10-01

    ... synthetic fabric or coated synthetic fabric (but not the purchase of the synthetic or coated synthetic fabric itself), if— (1) The fabric is to be used as a component of an end product that is not a textile product. Examples of textile products, made in whole or in part of fabric, include— (i) Draperies,...

  7. 25 CFR 225.37 - Penalties.

    Science.gov (United States)

    2010-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS... Area Director whose findings shall be conclusive, unless an appeal is taken pursuant to 25 CFR part 2... the operator to late payment charges. Late payment charges shall be calculated on the basis of...

  8. Vana praavusk Roth 225 / Milvi Hirvlaane

    Index Scriptorium Estoniae

    Hirvlaane, Milvi, 1936-

    2008-01-01

    Baltisaksa päritolu eesti vaimulikust, koolitegelasest ja luuletajast Johann Philipp von Rothist, tema osast Eesti kultuuriloos, võru keele arendamises, talurahvaseaduse ettevalmistamises ja paljus muus

  9. 48 CFR 225.103 - Exceptions.

    Science.gov (United States)

    2010-10-01

    ... (Acquisition, Technology, and Logistics) has determined that it is inconsistent with the public interest to... commercial technology; or (3) To maintain the same source of supply for spare and replacement parts (also see...) In order not to impair integration of the military and commercial industrial base. (B) Except...

  10. 19 CFR 351.225 - Scope rulings.

    Science.gov (United States)

    2010-04-01

    ... countries; or (C) Section 781(d) of the Act with respect to later-developed products which incorporate a... Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES... component under section 773(f)(3) of the Act. (h) Products completed or assembled in other foreign...

  11. 48 CFR 225.7003-1 - Definitions.

    Science.gov (United States)

    2010-10-01

    ...) Automotive item— (1) Means a self-propelled military transport tactical vehicle, primarily intended for use by military personnel or for carrying cargo, such as— (i) A high-mobility multipurpose wheeled...) Assembly, commercial derivative military article, commercially available off-the-shelf item,...

  12. 25 CFR 225.30 - Bonds.

    Science.gov (United States)

    2010-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS... Circular No. 570). (b) An operator may file a $75,000 bond for all geothermal, mining, or oil and gas... operator may file a $150,000 bond for full nationwide coverage to cover all geothermal or oil and...

  13. 12 CFR 225.4 - Corporate practices.

    Science.gov (United States)

    2010-01-01

    ... serious risk to the financial safety, soundness, or stability of a subsidiary bank of the bank holding company and is inconsistent with sound banking principles or the purposes of the BHC Act or the Financial... bank holding company's financial condition, after giving effect to the proposed purchase or...

  14. 12 CFR 225.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    .... (i) On a consolidated basis, the bank holding company maintains a total risk-based capital ratio of... bank holding company maintains a Tier 1 risk-based capital ratio of 6.0 percent or greater, as defined... capitalized under the capital adequacy regulations or guidelines applicable to the institution that have...

  15. 18 CFR 225.2 - General instructions.

    Science.gov (United States)

    2010-04-01

    ... from one media to another must be verified for accuracy and documented. Software and hardware required..., all removal and restoration activities are completed, and all costs are retired from the accounting records unless accounting adjustments resulting from reclassification and original costs studies have...

  16. TMFunction data: 225 [TMFunction[Archive

    Lifescience Database Archive (English)

    Full Text Available hang JT J Biol Chem. 2002 Nov 15;277(46):44268-77 mutagenesis 89 Vmax (pmol/mg/min) rapid filtration method; scintillation... counting 2cbz ... MRP1_HUMAN (P33527) Helix conformational change ATP binding; mutation; conformational change; cysteine

  17. 49 CFR 225.5 - Definitions.

    Science.gov (United States)

    2010-10-01

    ..., nerves, tendons, ligaments, joints, cartilage, and spinal discs. The term does not include disorders caused by slips, trips, falls, motor vehicle accidents, or other similar accidents. Examples of...

  18. 7 CFR 225.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... by the Food and Drug Administration and at levels consistent with State and local standards for such... experienced significant staff turnover from the prior year. NYSP means the National Youth Sports Program... and Drug Administration's Standard of Identity for yogurt, lowfat yogurt, and nonfat yogurt, (21...

  19. 48 CFR 225.872-1 - General.

    Science.gov (United States)

    2010-10-01

    ... Balance of Payments Program to the acquisition of qualifying country end products from the following... from application of the Buy American Act and the Balance of Payments Program as inconsistent with the... Greece Israel Italy Luxembourg Netherlands Norway Portugal Spain Sweden Switzerland Turkey United...

  20. 49 CFR 225.25 - Recordkeeping.

    Science.gov (United States)

    2010-10-01

    ... facility, provider and complete address; (24) Description of all procedures, medications, therapy, etc...”; (vii) Hospitalization for treatment as an inpatient; (viii) Multiple treatments or therapy sessions...—volunteer; volunteer—other; and nontrespasser-off railroad property; (25) Narrative description of...

  1. 24 CFR 91.225 - Certifications.

    Science.gov (United States)

    2010-04-01

    ... certifies that it lacks CDBG funds to cover the assessment. (5) Excessive force. A certification that the... CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS Local Governments; Contents of... provided family violence prevention or treatment services under any project assisted under the ESG...

  2. 2 CFR 225.10 - Authority.

    Science.gov (United States)

    2010-01-01

    ... Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR STATE, LOCAL... authority of the Budget and Accounting Act of 1921, as amended; the Budget and Accounting Procedures Act of 1950, as amended; the Chief Financial Officers Act of 1990; Reorganization Plan No. 2 of 1970;...

  3. MASTER: PKS 1142-225 optical flare

    Science.gov (United States)

    Pogrosheva, T.; Lipunov, V.; Podesta, R.; Levato, H.; Gorbovskoy, E.; Tiurina, N.; Balanutsa, P.; Kornilov, V.; Kuznetsov, A.; Gorbunov, I.; Krylov, A.; Lopez, C.; Podesta, F.; Saffe, C.; Kuvshinov, D.; Shumkov, V.

    2017-02-01

    MASTER-OAFA auto-detection system ( Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L ) discovered OT source at (RA, Dec) = 11h 45m 22.02s -22d 50m 31.4s on 2017-02-10.26340 UT. The OT unfiltered magnitude is 16.7m (mlimit=18.0m).

  4. 49 CFR 238.225 - Electrical system.

    Science.gov (United States)

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... wayside signaling systems. (3) To contain electromagnetic interference emissions, suppression of... or under-voltage conditions. This includes protection from both power frequency and harmonic...

  5. 25 CFR 225.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... consider any relevant factor, including, but not limited to: economic considerations, such as date of lease... sharing, service, managerial, lease (other than a lease entered into pursuant to the Act of May 11,...

  6. 45 CFR 225.1 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRAINING AND USE OF SUBPROFESSIONALS AND... integral part of the agency's service responsibilities to people and that can be performed by persons...

  7. 27 CFR 24.225 - General.

    Science.gov (United States)

    2010-04-01

    ... receive spirits without payment of tax from the bonded premises of a distilled spirits plant for uses as... fermentation on bonded wine premises located within the same State. If wine has been ameliorated, wine spirits... than 14 percent of alcohol by volume derived from fermentation. Spirits other than wine spirits may...

  8. Structural and conductivity properties of Bi{sub 0.775}Ln{sub 0.225}O{sub 1.5} oxide conductors (Ln = La, Pr, Nd, Sm, Eu, Gd, Tb, Dy) with rhombohedral Bi-Sr-O type

    Energy Technology Data Exchange (ETDEWEB)

    Drache, M.; Obbade, S.; Wignacourt, J.P.; Conflant, P. [USTL-ENSCL, Villeneuve d`Ascq (France). Lab. de Cristallochimie et Physicochimie du Solide

    1999-02-01

    This paper deals with structural and conductivity properties of the dimorphic Bi{sub 0.775}Ln{sub 0.225}O{sub 1.5} (Ln = La, Pr, Nd, Sm, Eu, Gd, Tb, Dy) hexagonal structure layer phases with rhombohedral Bi-Sr-O type. The evolutions, versus Ln{sub VI}{sup 3+} radius, of cell parameters, thermal expansion coefficients, electrical properties (conductivity and activation energy), and structural characteristics determined from Rietveld powder structure refinements, suggest two different domains (La-Sm) and (Gd-Dy), with the intermediate Eu sample, thus possibly characterizing two kinds of ordering in the mixed cationic layer. The best conductivity properties obtained for Bi{sub 0.775}La{sub 0.225}O{sub 1.5} ({sigma}{sub 400{degree}C} = 10{sup {minus}3} S cm{sup {minus}1} with E{sub a} = 0.8 eV) are discussed and justified.

  9. 49 CFR 571.225 - Standard No. 225; Child restraint anchorage systems.

    Science.gov (United States)

    2010-10-01

    ... parallel to the vehicle's vertical longitudinal plane through the X point on the test device, and, (2...) Applied— (1) In a forward direction parallel to the vehicle's longitudinal vertical plane, and (2... parallel to the vehicle's longitudinal centerline; (2) Initially, along a horizontal line or along any...

  10. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization.

    Directory of Open Access Journals (Sweden)

    Jaspreet Singh Jaggi

    Full Text Available BACKGROUND: Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen and drug delivery and results in radiotherapy and chemotherapy resistance, respectively. Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature. METHODOLOGY AND PRINCIPAL FINDINGS: Actinium-225 ((225Ac-E4G10, an alpha-emitting antibody construct reactive with the unengaged form of vascular endothelial cadherin, is capable of potent, selective killing of tumor neovascular endothelium and late endothelial progenitors in bone-marrow and blood. No specific normal-tissue uptake of E4G10 was seen by imaging or post-mortem biodistribution studies in mice. In a mouse-model of prostatic carcinoma, (225Ac-E4G10 treatment resulted in inhibition of tumor growth, lower serum prostate specific antigen level and markedly prolonged survival, which was further enhanced by subsequent administration of paclitaxel. Immunohistochemistry revealed lower vessel density and enhanced tumor cell apoptosis in (225Ac-E4G10 treated tumors. Additionally, the residual tumor vasculature appeared normalized as evident by enhanced pericyte coverage following (225Ac-E4G10 therapy. However, no toxicity was observed in vascularized normal organs following (225Ac-E4G10 therapy. CONCLUSIONS: The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy.

  11. Lithium ion conductivity in the Li-ADPESS (Ca{sub X}Sr{sub 1-X}){sub 0.56}Li{sub 0.33}Ta{sub 0.775}M(III){sub 0.225}O{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Harada, Y.; Kuwano, J.; Saito, Y. [Science Univ. of Tokyo (Japan). Dept. of Industrial Chemistry

    2002-07-01

    Lithium-ion-conducting A-site-deficient perovskite solid solutions (Li-ADPESSs) were synthesized in three series, (Ca{sub X}Sr{sub 1-X}){sub 0.56}Li{sub 0.33}Ta{sub 0.775}M(III){sub 0.225}O{sub 3} [M(III)=Cr,Fe,Ga: M(III)-series] whose A-site ion concentration was fixed at A{sub 0.56}Li{sub 0.33}. A single-phase ADPESSs formed in the whole range of the Cr- and Fe-series, while the formation was limited in a range X<0.6 of the Ga-series. In all the series, the relation between bulk conductivity and the cube root of the perovskite cell volume (V) showed dome-shaped dependence with a maximum at V{sup 1/3}{approx}394-395 pm, which was much larger than an optimal V{sup 1/3}{approx}387 pm for Li-ADPESSs with the (Lanthanoids){sub 0.56}M(IV)O{sub 3} framework. Their activation energies for lithium ion conduction in the optimized Cr- and Fe-series samples were almost the same as that in La{sub 0.56}Li{sub 0.33}TiO{sub 3}, suggesting the importance of the optimization of the perovskite cell volume for the individual frameworks. (orig.)

  12. (abstract) Determination of the Specific Heat and Total Hemispherical Total Emissivity of the Highly Undercooled Zr(sub 41.2)Ti(sub 13.8)Cu(sub 12.5)Ni(sub 10.0)Be(sub 22.5) Alloy

    Science.gov (United States)

    Busch, R.; Kim, Y. J.; Johnson, W. L.; Rulison, A. J.; Rhim, W. K.

    1995-01-01

    High temperature high vacuum electrostatic levitation was combined with DSC experiments to determine the specific heat C(sub p) of the undercooled Zr(sub 41.2)Ti(sub 13.8)Cu(sub 12.5)Ni(sub 10.0)Be(sub 22.5) liquid as a function of temperature. The containerless approach made it possible to undercool the melt to the glass transition temperature without inducing nucleation. Because the cooling process was purely radiative, noncontact temperature measurement techniques could be used to determine the specific heat to total hemispherical emissivity ratio, C(sub p)/epsilon(sub t), for the undercooled liquid region. Using C(sub p) values which were independently obtained by DSC, epsilon(sub t) could be determined. With knowledge of C(sub p) of the undercooled liquid it was possible to determine other thermodynamic properties such as Gibbs free energy and entropy as a function of undercooling.

  13. Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution

    Science.gov (United States)

    Finn, R.; McDevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.

    2005-12-01

    In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented.

  14. Dicty_cDB: AFO225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ) Danio rerio gelsolin mRNA, complet... 96 1e-18 BC125898_1( BC125898 |pid:none) Danio rerio scinderin like ...1( BC155581 |pid:none) Danio rerio scinderin like a, mRNA... 95 4e-18 protein update 2009. 4.26 PSORT psg: 0

  15. 48 CFR 252.225-7013 - Duty-free entry.

    Science.gov (United States)

    2010-10-01

    ...) Scrap or salvage; or (ii) Competitive sale made, directed, or authorized by the Contracting Officer. (d... shipment under 19 CFR part 142 and notify Commander, Defense Contract Management Agency (DCMA) New York... Contractor's name, address, and Commercial and Government Entity (CAGE) code; (2) Prime contract number...

  16. 40 CFR 98.225 - Procedures for estimating missing data.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Procedures for estimating missing data... estimating missing data. A complete record of all measured parameters used in the GHG emissions calculations... substitute data value for the missing parameter shall be used in the calculations as specified in...

  17. 25 CFR 225.1 - Purpose and scope.

    Science.gov (United States)

    2010-04-01

    ... environmental or cultural impact resulting from such development. Pursuant to section 4 of the IMDA (25 U.S.C... to provide reasonable provisions satisfactorily addressing the issues of valuation, method of...

  18. Dicty_cDB: VSD225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available skitlvlcviqkvkskvtfsdq sprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---VYINNVKSTSRR**lqsi...*lsdkentgrermvftsiskitlvlcviqkvkskvtfsdq sprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---...iqkvkskvtf sdqsprnapiygqrlppmpvplfk*ihiklkq Homology vs CSM-cDNA Score E Sequences producing significant ali

  19. Dicty_cDB: AHA225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available rdch*dlvwxhqxvtheyvchi*hxxigelkscxli*HEDLFLTXLFIRIXDGSMV GSDNTXQTVSLLFXSLIKSVSPLK...NCN*sivxgfnvttelsslraxstnnlsgaflr Translated Amino Acid sequence (All Frames) Frame A: ---qrdch*dlvwxhqxvtheyvchi*hxxigelkscx

  20. 48 CFR 252.225-7020 - Trade Agreements Certificate.

    Science.gov (United States)

    2010-10-01

    ... country end product, nondesignated country end product, qualifying country end product, and U.S.-made end... are U.S.-made, qualifying country, or designated country end products unless— (i) There are no offers... identification of country of origin. (1) For all line items subject to the Trade Agreements clause of......

  1. 48 CFR 52.225-6 - Trade Agreements Certificate.

    Science.gov (United States)

    2010-10-01

    ... end products those supplies that are not U.S.-made or designated country end products. Other End Products Line Item No.: Country of Origin: (List as necessary), (c) The Government will evaluate offers in... listed in paragraph (b) of this provision, is a U.S.-made or designated country end product, as...

  2. 48 CFR 52.225-2 - Buy American Act Certificate.

    Science.gov (United States)

    2010-10-01

    ... solicitation entitled “Buy American Act—Supplies.” (b) Foreign End Products: Line Item No.: Country of Origin...: Buy American Act Certificate (FEB 2009) (a) The offeror certifies that each end product, except those listed in paragraph (b) of this provision, is a domestic end product and that for other than COTS...

  3. 12 CFR 225.131 - Activities closely related to banking.

    Science.gov (United States)

    2010-01-01

    ... specialized lending provisions; marketing operations, including research, market development and advertising...; purchasing policies and practices; cost analysis, capital adequacy and planning; auditing;...

  4. 12 CFR 225.24 - Procedures for other nonbanking proposals.

    Science.gov (United States)

    2010-01-01

    ...: (i) A description of the proposal, including a description of each proposed activity, and the effect of the proposal on competition among entities engaging in each proposed activity in each relevant... consolidated assets of less than $150 million: (A) A pro forma parent-only balance sheet as of the most...

  5. 12 CFR 225.66 - Professional association membership; competency.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Professional association membership; competency...; competency. (a) Membership in appraisal organizations. A State certified appraiser or a State licensed...) Competency. All staff and fee appraisers performing appraisals in connection with federally...

  6. 25 CFR 225.22 - Approval of minerals agreements.

    Science.gov (United States)

    2010-04-01

    ... financial return to the Indian parties thereto; the extent, nature, value or disposition of the mineral resources; or the production, products or proceeds thereof, shall be held by the Department of the Interior... interest of the Indian mineral owner; (2) The minerals agreement does not have adverse cultural, social,...

  7. 12 CFR 225.12 - Transactions not requiring Board approval.

    Science.gov (United States)

    2010-01-01

    ... Capital Adequacy Guidelines (appendices A, B, C, D, and E of this part); (v) At least 10 days prior to the... Board's Capital Adequacy Guidelines (appendices A, B, C, D, and E of this part). (e) Holding...

  8. 12 CFR 225.1 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ...)). (11) Appendix A to the regulation contains the Board's Risk-Based Capital Adequacy Guidelines for bank holding companies. (12) Appendix B contains the Board's Capital Adequacy Guidelines for measuring leverage... statement governing small bank holding companies. (14) Appendix D contains the Board's Capital...

  9. 14 CFR 125.225 - Flight data recorders.

    Science.gov (United States)

    2010-01-01

    ... recording intervals specified in appendix D of this part: (1) Time; (2) Altitude; (3) Airspeed; (4) Vertical...) Vertical acceleration; (5) Heading; (6) Time of each radio transmission either to or from air traffic... airplane equipped with a digital data bus and ARINC 717 digital flight data acquisition unit (DFDAU)...

  10. 7 CFR 225.15 - Management responsibilities of sponsors.

    Science.gov (United States)

    2010-01-01

    ...) Examples of income that should be provided on the application, including: Earnings, wages, welfare benefits... assistance programs for households with incomes at or below 185 percent of the Federal poverty level); or (3... identifying children from low-income households who are potentially eligible for Medicaid or SCHIP for...

  11. 12 CFR 225.28 - List of permissible nonbanking activities.

    Science.gov (United States)

    2010-01-01

    ... a real estate project to one or more investors, if the bank holding company and its affiliates do... plans, providing administrative services to plans, and developing employee communication programs...

  12. 7 CFR 2.25 - Assistant Secretary for Civil Rights.

    Science.gov (United States)

    2010-01-01

    ..., Congressional mandates, and other laws, rules, and regulations, as appropriate. (viii) Actions to develop and..., including the authority: (A) To make changes in programs and procedures designed to eliminate...

  13. Dicty_cDB: AFN225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available *insmmnnnnnhkkfqin nnfknnklihprifnin*ii*inhskmtiimiklkn*kmmiiilminkltmvnlkimlkn fli*MMLMIILNKLTTTTTTSIIITITT...nnnhkkfqin nnfknnklihprifnin*ii*inhskmtiimiklkn*kmmiiilminkltmvnlkimlkn fli*MMLMIILNKLTTTTTTSIIITITTLKLINQRK

  14. Dicty_cDB: VFG225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available collected Valencia Sweet Orange (Citrus sinensis (L.) Osbeck) Citrus sinensis cDNA clone MVF-70_B02 5', mRNA...om field-collected Valencia Sweet Orange (Citrus sinensis (L.) Osbeck) Citrus sinensis cDNA clone MVF-82_F01

  15. 7 CFR 225.16 - Meal service requirements.

    Science.gov (United States)

    2010-01-01

    ... 12 and up may be served larger portions based on the greater food needs of older boys and girls. (1... other meat alternates based on available nutritional data. Acorns, chestnuts, and coconuts shall not be... pattern requirements contained in the Child and Adult Care Food Program regulations (7 CFR part 226)....

  16. 47 CFR 76.225 - Commercial limits in children's programs.

    Science.gov (United States)

    2010-10-01

    ... purposes of selling a product or service and promotions of television programs or video programming... purposes, including either e-commerce or advertising; (3) The Web site's home page and other menu pages are... site to which viewers are directed by the Web site address is not used for e-commerce, advertising,...

  17. 7 CFR 225.11 - Corrective action procedures.

    Science.gov (United States)

    2010-01-01

    ... suspected fraud or criminal abuse in the Program which would result in a loss or misuse of Federal funds... through its corporate organization, officers, employees, or otherwise, as an institution...

  18. 1935 15' Quad #225 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  19. Dicty_cDB: SHG225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available STIHSPETFNQWFHNYPGVNLPINYQITLTQSTTNPNVYAYTND AFFPIDGQGFDNKTNYPYEAVYRDERGTPHNFHFCLQIHSMFAYXKGDTFYFNGDDDVWV FM--- ---SCLYNYTEST...ngftiiqe*iyqliikll*lkvlqiqmfmhiqm mpffq*mdkdliirqiihmkpyiemnvehhiiftfvckftqclhixkvilsilmvmmmfg yl--- ---SCLYNYTEST

  20. 48 CFR 252.225-7021 - Trade agreements.

    Science.gov (United States)

    2010-10-01

    ... (Australia, Bahrain, Canada, Chile, Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Mexico..., Belgium, Bulgaria, Canada, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany,...

  1. 48 CFR 52.225-5 - Trade Agreements.

    Science.gov (United States)

    2010-10-01

    ... Agreement country (Aruba, Austria, Belgium, Bulgaria, Canada, Cyprus, Czech Republic, Denmark, Estonia... Taipei))”, or United Kingdom); (2) A Free Trade Agreement country (Australia, Bahrain, Canada, Chile, Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Mexico, Morocco, Nicaragua, Oman,...

  2. Dicty_cDB: AFL225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1362 |pid:none) Plasmodium falciparum 3D7 chromo... 37 1.2 AY714675_1( AY714675 |pid:none) Epizootic hemorrhagic... disease viru... 35 4.6 AY714694_1( AY714694 |pid:none) Epizootic hemorrhagic

  3. 7 CFR 225.9 - Program assistance to sponsors.

    Science.gov (United States)

    2010-01-01

    ... changes in the series for food away from home of the Consumer Price Index(CPI) for all urban consumers... sponsors information on available commodities. Sponsors shall use in the Program food donated by the... Program, and operate more than one child nutrition program under a single State agency, must use a...

  4. 20 CFR 702.225 - Withdrawal of a claim.

    Science.gov (United States)

    2010-04-01

    ... HARBOR WORKERS' COMPENSATION ACT AND RELATED STATUTES ADMINISTRATION AND PROCEDURE Claims Procedures... request for withdrawal is approved, such withdrawal shall be without prejudice to the filing of another claim, subject to the time limitation provisions of section 13 of the Act and of the regulations in...

  5. Dicty_cDB: VHE225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available miliaris genomic,genomic survey sequence. 40 0.058 2 EK225313 |EK225313.1 1095460156784 Global-Ocean-Samplin...g_GS-31-01-01-1P3-1P8KB marine metagenome genomic clone 1061005707342 3', genomic survey... fsbb001f209i23k0 Sorghum methylation filtered library (LibID: 104) Sorghum bicolor genomic clone fsbb001f209i23, genomic survey...ibrary (LibID: 104) Sorghum bicolor genomic clone fsbb001f208d23, genomic survey ...orghum bicolor genomic clone fsbb001f137c21, genomic survey sequence. 46 1.1 1 CL168450 |CL168450.1 104_366_

  6. Dicty_cDB: SHB225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available J132370 |pid:none) Allogromia sp. mRNA for actin 1. 254 6e-66 AY452189_1( AY452189 |pid:none) Sorosphaera veronica...e actin 1 gene... 248 4e-64 AY452190_1( AY452190 |pid:none) Sorosphaera veronicae actin 2 gene... 248

  7. 7 CFR 225.6 - State agency responsibilities.

    Science.gov (United States)

    2010-01-01

    ... consultative, technical, and managerial personnel to administer the Program, monitor performance, and measure... Program to an area in which poor economic conditions exist; a significant number of needy children will... area in which poor economic conditions exist. However, for sites that a sponsor proposes to...

  8. 7 CFR 225.7 - Program monitoring and assistance.

    Science.gov (United States)

    2010-01-01

    ... Rehabilitation Act of 1973, the Age Discrimination Act of 1975, and the Department's regulations concerning nondiscrimination (7 CFR parts 15, 15a and 15b), including requirements for racial and ethnic participation data... regulations, the Department's non-discrimination regulations (7 CFR part 15) and any other...

  9. 40 CFR 180.225 - Phosphine; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ..., bean, green 0.1 Corn, field, grain 0.1 Corn, pop, grain 0.1 Cotton, undelinted seed 0.1 Date, dried fruit 0.1 Dill, seed 0.01 Eggplant 0.01 Endive 0.01 Grapefruit 0.01 Hazelnut 0.1 Kumquat 0.01 Lemon 0.01 Lettuce 0.01 Lime 0.01 Mango 0.01 Millet, grain 0.1 Mushroom 0.01 Nut, brazil 0.1 Oat, grain 0.1 Okra...

  10. 5 CFR 532.225 - Nonappropriated fund survey jobs.

    Science.gov (United States)

    2010-01-01

    ...) 7 Cook 8 Carpenter 9 Painter 9 Automotive Mechanic 10 Electrician 10 (b) A lead agency may not omit... Attendant 4 Tractor Operator 6 Bowling Equipment Mechanic 7 Building Maintenance Worker 7 Vending Machine Mechanic 8 Building Maintenance Worker 8 Air Conditioning Equipment Mechanic 8 Truck Driver (Trailer) 8...

  11. 50 CFR 600.225 - Rules of conduct.

    Science.gov (United States)

    2010-10-01

    ... Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... are responsible for maintaining high standards of ethical conduct among themselves, their staffs, and...) Council members, employees, and contractors must comply with the Federal Cost Principles Applicable...

  12. 45 CFR 225.2 - State plan requirements.

    Science.gov (United States)

    2010-10-01

    ...), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRAINING AND USE OF... of persons of low income and, where applicable, of recipients and for that purpose will provide for... employment of persons of low income and little or no formal education, including employment of young...

  13. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  14. Interactions with ATP, DNA Cleavage and Anti-tumor Activities of Complexes with Anions [Mo(V)O2(O2CeH4)2]3-, [Mo(Ⅴ)0.5W(Ⅵ)0.5O2(O2C6H4)2]2.5- and [W(Ⅵ)O2(O2C6H4)2]2-

    Institute of Scientific and Technical Information of China (English)

    鲁晓明; 姜凌; 毛希安; 叶朝晖; 卢景芬; 崔景荣

    2005-01-01

    (NH3CH2CH2NH2)3[Mo(Ⅴ)O2(O2C6H4)2] (1), (NH3CH2CH2NH2)2.5[Mo(Ⅴ)o.sW(Ⅵ)o.502(O2C6H4)2] (2) and(NH3CH2CH2NH2)2[VC(Ⅵ)O2(O2C6H4)2] (3) were synthesized, structurally characterized by X-ray diffraction analysis, and studied on their interactions with ATP, their DNA cleavage activities and antitumor properties. The redox state of molybdenum was not changed on going from crystal to aqueous solutions in complexes 1 and 2, while tungsten underwent reduction from W(VI) to W(V) in complexes 2 and 3. ATP promoted the oxidation of both molybdenum and tungsten from M(Ⅴ) to M(Ⅵ) and the hydrolysis of catecholate ligands in solution consisting of ATP and the complexes. Complex 1 possesses fairly good activity to DNA cleavage and against tumor S180 in mice, and is more effective than the control drug cyclophosphamide under the identical conditions. However, complexes 2 and 3 exhibited marginal effectiveness. The effectiveness of anti-tumor of the complexes was related positively to their DNA cleavage activities and their hydrolysis of catecholate ligands.

  15. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  16. 12 CFR Appendix F to Part 225 - Interagency Guidelines Establishing Information Security Standards

    Science.gov (United States)

    2010-01-01

    ... Relationships Risk Management Principles,” Nov. 1, 2001; FDIC FIL 68-99, Risk Assessment Tools and Practices for... Table of Contents I. Introduction A. Scope B. Preservation of Existing Authority C. Definitions II. Standards for Safeguarding Customer Information A. Information Security Program B. Objectives...

  17. CTEPP STANDARD OPERATING PROCEDURE FOR CONDUCTING INTERNAL FIELD AUDITS AND QUALITY CONTROL (SOP-2.25)

    Science.gov (United States)

    This SOP describes the method for conducting internal field audits and quality control procedures. Internal field audits will be conducted to ensure the collection of high quality data. Internal field audits will be conducted by Field Auditors (the Field QA Officer and the Field...

  18. 2 CFR Appendix B to Part 225 - Selected Items of Cost

    Science.gov (United States)

    2010-01-01

    ... costs of advertising media and corollary administrative costs. Advertising media include magazines... maintaining the image of the governmental unit or maintaining or promoting understanding and favorable..., or similar local governmental body, such as a county supervisor, city council, school board,...

  19. 78 FR 38093 - Thirteenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    Science.gov (United States)

    2013-06-25

    ... administrative items. Review agenda. Review and approval of summary from last Plenary meeting. Status of TOR and... FRAC comments. Create plan and schedule for updating DO-311 per updated TOR. Establish agenda for...

  20. 12 CFR 225.63 - Appraisals required; transactions requiring a State certified or licensed appraiser.

    Science.gov (United States)

    2010-01-01

    ... Appraisals required; transactions requiring a State certified or licensed appraiser. (a) Appraisals required. An appraisal performed by a State certified or licensed appraiser is required for all real estate... or United States government sponsored agency; or (ii) Involves a residential real estate...

  1. 10 CFR 5.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Educational institutions eligible to submit transition... institutions eligible to submit transition plans. (a) Application. This section applies to each educational..., 1965. (b) Provision for transition plans. An educational institution to which this section...

  2. 29 CFR 36.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Educational institutions eligible to submit transition plans... institutions eligible to submit transition plans. (a) Application. This section applies to each educational..., 1965. (b) Provision for transition plans. An educational institution to which this section...

  3. 44 CFR 19.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Educational institutions... Educational institutions eligible to submit transition plans. (a) Application. This section applies to each educational institution to which §§ 19.300 through 19.310 apply that: (1) Admitted students of only one sex...

  4. 25 CFR 225.36 - Minerals agreement cancellation; Bureau of Indian Affairs notice of noncompliance.

    Science.gov (United States)

    2010-04-01

    ... INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS AGREEMENTS Minerals Agreements... cancel the minerals agreement, specifying the basis for the cancellation. Cancellation of a minerals... Indian Affairs, the orders may be appealed under 25 CFR part 2. If the orders are issued by the...

  5. 12 CFR 225.17 - Notice procedure for one-bank holding company formations.

    Science.gov (United States)

    2010-01-01

    ... dissenting shareholders' rights under state or federal law; 3 3 A shareholder of a bank in reorganization... procedure is not available in cases in which the exercise of dissenting shareholders' rights would cause a... shareholder or shareholders who control at least 67 percent of the shares of the bank will...

  6. 48 CFR 952.225-70 - Subcontracting for nuclear hot cell services.

    Science.gov (United States)

    2010-10-01

    ... related to the examination of, or performance of various operations on, nuclear fuel rods, control... from nuclear reactors, which are performed in specialized facilities located away from commercial... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Subcontracting for...

  7. 49 CFR 225.19 - Primary groups of accidents/incidents.

    Science.gov (United States)

    2010-10-01

    ... equipment accidents/incidents are collisions, derailments, fires, explosions, acts of God, and other events... following outcomes, and this outcome is a new case or a significant aggravation of a pre-existing injury or... of Transportation (49 CFR 1.49(g) and (m)) Editorial Note: For Federal Register citations...

  8. 2 CFR Appendix C to Part 225 - State/Local-Wide Central Service Cost Allocation Plans

    Science.gov (United States)

    2010-01-01

    ... Federal awards on the basis of a beneficial or causal relationship between the expenses incurred and the... process. All costs and other data used to distribute the costs included in the plan should be supported...

  9. 2 CFR Appendix E to Part 225 - State and Local Indirect Cost Rate Proposals

    Science.gov (United States)

    2010-01-01

    ... costs, direct salaries and wages, staff hours applied, square feet used, hours of usage, number of... include the physical location of the work, the level of administrative support required, the nature of the... documentation must be retained for audit in accordance with the records retention requirements contained in...

  10. 47 CFR 22.225 - Certifications, disclosures, records maintenance, and definitions.

    Science.gov (United States)

    2010-10-01

    ... (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Licensing Requirements and Procedures Competitive... maintenance. All winning bidders qualifying as small businesses shall maintain at their principal place of business an updated file of ownership, revenue, and asset information, including any documents necessary...

  11. 48 CFR 252.225-7022 - Trade agreements certificate-inclusion of Iraqi end products.

    Science.gov (United States)

    2010-10-01

    ... products: (Country of Origin) (Line Item Number) (End of provision) ... Certificate—Inclusion of Iraqi End Products (SEP 2008) (a) Definitions. Designated country end product, Iraqi end product, nondesignated country end product, qualifying country end product, and U.S.-made...

  12. 48 CFR 252.225-7000 - Buy American Act-Balance of Payments Program Certificate.

    Science.gov (United States)

    2010-10-01

    ... Item Number) (Country of Origin) (3) The following end products are other foreign end products... definition of “domestic end product”: (Line Item Number) (Country of Origin (If known)) (End of provision) ... end product,” “qualifying country,” “qualifying country end product,” and “United States” have...

  13. 40 CFR 745.225 - Accreditation of training programs: target housing and child-occupied facilities.

    Science.gov (United States)

    2010-07-01

    ... equipment to be used for lecture and hands-on training. (B) A copy of the course test blueprint for each...) Demonstrated experience, education, or training in the construction industry including: lead or asbestos... needed to provide instruction specific to the lecture, hands-on activities, or work practice...

  14. 77 FR 8325 - Sixth Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

    Science.gov (United States)

    2012-02-14

    ... with Li-Ion Batteries (15 min). Results of EFB thermal runaway on flightdeck (smoke and toxic gases... Batteries and Battery Systems, Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise...

  15. SU-E-J-225: CEST Imaging in Head and Neck Cancer Patients

    Energy Technology Data Exchange (ETDEWEB)

    Wang, J; Hwang, K; Fuller, C; Mohamed, A; Ding, Y; Frank, S; Hazle, J; Zhou, J [UT MD Anderson Cancer Center, Houston, TX (United States)

    2015-06-15

    Purpose: Chemical Exchange Saturation Transfer (CEST) imaging is an MRI technique enables the detection and imaging of metabolically active compounds in vivo. It has been used to differentiate tumor types and metabolic characteristics. Unlike PET/CT,CEST imaging does not use isotopes so it can be used on patient repeatedly. This study is to report the preliminary results of CEST imaging in Head and Neck cancer (HNC) patients. Methods: A CEST imaging sequence and the post-processing software was developed on a 3T clinical MRI scanner. Ten patients with Human papilloma virus positive oropharyngeal cancer were imaged in their immobilized treatment position. A 5 mm slice CEST image was acquired (128×128, FOV=20∼24cm) to encompass the maximum dimension of tumor. Twenty-nine off-set frequencies (from −7.8ppm to +7.8 ppm) were acquired to obtain the Z-spectrum. Asymmetry analysis was used to extract the CEST contrasts. ROI at the tumor, node and surrounding tissues were measured. Results: CEST images were successfully acquired and Zspectrum asymmetry analysis demonstrated clear CEST contrasts in tumor as well as the surrounding tissues. 3∼5% CEST contrast in the range of 1 to 4 ppm was noted in tumor as well as grossly involved nodes. Injection of glucose produced a marked increase of CEST contrast in tumor region (∼10%). Motion and pulsation artifacts tend to smear the CEST contrast, making the interpretation of the image contrast difficult. Field nonuniformity, pulsation in blood vesicle and susceptibility artifacts caused by air cavities were also problematic for CEST imaging. Conclusion: We have demonstrated successful CEST acquisition and Z-spectrum reconstruction on HNC patients with a clinical scanner. MRI acquisition in immobilized treatment position is critical for image quality as well as the success of CEST image acquisition. CEST images provide novel contrast of metabolites in HNC and present great potential in the pre- and post-treatment assessment of patients undergoing radiation therapy.

  16. 22 CFR 225.101 - To what does this policy apply?

    Science.gov (United States)

    2010-04-01

    ... instructional strategies, or (ii) research on the effectiveness of or the comparison among instructional techniques, curricula, or classroom management methods. (2) Research involving the use of educational...

  17. O2 absorption cross sections /187-225 nm/ from stratospheric solar flux measurements

    Science.gov (United States)

    Herman, J. R.; Mentall, J. E.

    1982-10-01

    The absorption cross sections of molecular oxygen are calculated in the wavelength range from 187 to 230 nm from solar flux measurements obtained within the stratosphere. Within the Herzberg continuum wavelength region the molecular oxygen cross sections are found to be about 30% smaller than the laboratory results of Shardanand and Rao (1977) from 200 to 210 nm and about 50% smaller than those of Hasson and Nicholls (1971). At wavelengths longer than 210 nm the cross sections agree with those of Shardanand and Rao. The effective absorption cross sections of O2 in the Schumann-Runge band region from 187 to 200 nm are calculated and compared to the empirical fit given by Allen and Frederick (1982). The calculated cross sections indicate that the transmissivity of the atmosphere may be underestimated by the use of the Allen and Frederic cross sections between 195 and 200 nm. The ozone column content between 30 and 40 km and the relative ozone cross sections are determined from the same solar flux data set.

  18. 12 CFR 225.143 - Policy statement on nonvoting equity investments by bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... or indirectly owns, controls, or holds with power to vote 25 per cent or more of the voting shares of... leave management free to conduct banking and permissible nonbanking activities. Another step to...

  19. 49 CFR 173.225 - Packaging requirements and other provisions for organic peroxides.

    Science.gov (United States)

    2010-10-01

    ... Cyclohexanone peroxide(s) UN3104 ≤91 ≥9 OP6 13 Cyclohexanone peroxide(s) UN3105 ≤72 ≥28 OP7 5 Cyclohexanone peroxide(s) [as a paste] UN3106 ≤72 OP7 5, 21 Cyclohexanone peroxide(s) Exempt ≤32 >68 Exempt 29...

  20. Geochemistry of Precambrian carbonates. IV - Early Paleoproterozoic (2.25 +/- 0.25 Ga) seawater

    Science.gov (United States)

    Veizer, Jan; Clayton, R. N.; Hinton, R. W.

    1992-01-01

    The mineralogy, chemistry, and isotopic composition of the Malmani Dolomite, Duck Creek Dolomite, and Bruce 'Limestone' Member of the Espanola Formation are studied in an effort to restrict the first- and second-order variations in isotopic composition of Early Paleoproterozoic seawater. The diagenetic rank is found to increase in the order Duck Creek less than Bruce less than Malmani. The interpolation of alteration trends to 'best' value yields an estimate of 0.70550 for Sr-87/Sr-86. For delta C-13, the measured range of 0 +/- 1.5 percent PDB is similar to that observed for Phanerozoic marine carbonates, while the 'best' delta O-18 value for dolostones is -5 percent PDB, depleted in O-18 relative to Phanerozoic counterparts but comparable to estimates obtained for Archean facies. The isotope geochemistry and mineralogy of Bruce 'Limestone' Member is consistent with the proposition that the sequence was deposited in a lacustrine environment.

  1. 2 CFR Appendix A to Part 225 - General Principles for Determining Allowable Costs

    Science.gov (United States)

    2010-01-01

    ... applicable CAS requirements when estimating, accumulating and reporting costs under CAS-covered contracts... incorporated as a non-profit corporation under State law), any other regional or interstate government entity... concept of netting such credit items (including any amounts used to meet cost sharing or...

  2. 12 CFR 225.118 - Computer services for customers of subsidiary banks.

    Science.gov (United States)

    2010-01-01

    ... subsidiary banks. (a) The question has been presented to the Board of Governors whether a wholly-owned... will the service company provide services for anyone other than its affiliated banks. Moreover, it will not hold itself out as, nor will its parent corporation or affiliated banks represent it to...

  3. 48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

    Science.gov (United States)

    2010-10-01

    ... (Aruba, Austria, Belgium, Bulgaria, Canada, Cyprus, Czech Republic, Denmark, Estonia, Finland, France...); (2) A Free Trade Agreement country (Australia, Bahrain, Canada, Chile, Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Mexico, Morocco, Nicaragua, Peru, or Singapore); (3) A...

  4. 48 CFR 52.225-11 - Buy American Act-Construction Materials under Trade Agreements.

    Science.gov (United States)

    2010-10-01

    ... Government Procurement Agreement country (Aruba, Austria, Belgium, Bulgaria, Canada, Cyprus, Czech Republic... United Kingdom); (2) A Free Trade Agreement country (Australia, Bahrain, Canada, Chile, Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Mexico, Morocco, Nicaragua, Oman, Peru, or...

  5. 40 CFR 80.225 - What is the definition of a small refiner?

    Science.gov (United States)

    2010-07-01

    ..., the refiner shall include the employees and crude capacity of any subsidiary companies, any parent company and subsidiaries of the parent company, and any joint venture partners. A subsidiary under this paragraph means any subsidiary in which the refiner or parent company has a 50% or greater...

  6. 75 FR 43801 - Airworthiness Directives; Eurocopter France (ECF) Model EC225LP Helicopters

    Science.gov (United States)

    2010-07-27

    ... support lugs at their attachment points on the reinforcement ring where the dome fairing is secured. Also... restrainer support lugs in the area of their attachment points on the reinforcement ring where the dome.... Will not have a significant economic impact, positive or negative, on a substantial number of...

  7. 78 FR 22512 - Foreign-Trade Zone (FTZ) 225-Springfield, Missouri; Notification of Proposed Production Activity...

    Science.gov (United States)

    2013-04-16

    ... Production Activity; General Dynamics Ordnance and Tactical Systems Munitions Services (Demilitarization of... under Section 400.38 of the Board's regulations. The facility is used for the demilitarization of... could allow GDOTS to conduct demilitarization activity on imported articles at the facility....

  8. 48 CFR 252.225-7006 - Quarterly reporting of actual contract performance outside the United States.

    Science.gov (United States)

    2010-10-01

    ... of DD Form 2139 from the Contracting Officer or via the Internet at http://www.dtic.mil/whs...) Definition. United States, as used in this clause, means the 50 States, the District of Columbia,...

  9. 12 CFR 225.200 - Conditions to Board's section 20 orders.

    Science.gov (United States)

    2010-01-01

    ... include observing corporate formalities (such as the maintenance of separate accounting and corporate...) Introduction. Under section 20 of the Glass-Steagall Act (12 U.S.C. 377) and section 4(c)(8) of the Bank... standard, the manager of a branch or agency of a foreign bank generally will be considered to be the...

  10. 49 CFR 40.225 - What form is used for an alcohol test?

    Science.gov (United States)

    2010-10-01

    ... colored paper, or have clearly discernable borders or designation statements on Copy 2 and Copy 3. When... foreign-language version of the ATF approved by ODAPC. You may use such a non-English language form only in a situation where both the employee and BAT/STT understand and can use the form in that language....

  11. Highly Ionized Plasma in the Halo of a Luminous Spiral Galaxy Near z=0.225

    CERN Document Server

    Narayanan, Anand; Wakker, Bart P

    2010-01-01

    We present analyses of the physical conditions in the z=0.22496 and z=0.22638 multi-phase O VI absorption systems detected in the ultraviolet HST/STIS and FUSE spectra of the quasar H1821+643. Both absorbers are likely associated with the extended halo of a ~2L* Sbc-Sc galaxy situated at a projected distance of ~116 kpc from the sight line. The z=0.22496 absorber is detected in C II, C III, C IV, O III, O VI, Si II, Si III and H I at > 3 sigma significance. The low and intermediate ions in this absorber are consistent with an origin in photoionized gas with [Si/H] and [C/H] of -0.6 dex. In contrast, the broader O VI absorption is likely produced in collisionally ionized plasma under nonequilibrium conditions. The z=0.22638 system has broad-Lya (BLA) and C III absorption offset by v = -53 km/s from O VI. The H I and C III line widths for the BLA imply T = 1.1 x 10^5 K. For non-equilibrium cooling we obtain [C/H] of -1.5 dex and a total hydrogen column of N(H) = 3.2 x 10^{18} cm^-2 in the BLA. The O VI, offset ...

  12. 48 CFR 252.225-7009 - Restriction on Acquisition of Certain Articles Containing Specialty Metals.

    Science.gov (United States)

    2010-10-01

    ... particles in circuits, using interconnections of electrical devices such as resistors, inductors, capacitors... of the following elements: Aluminum, chromium, cobalt, molybdenum, nickel, niobium (columbium...., a special reinforced handle made of specialty metal is added to a COTS item). (C) If two or...

  13. 18 CFR 225.3 - Schedule of records and periods of retention.

    Science.gov (United States)

    2010-04-01

    .... Journal vouchers and journal entries. 9. Cash books. 10. Voucher registers. 11. Vouchers. Insurance 12... ledgers. 19. Summary sheets. 20. Appraisals and valuations. 21. Engineering records. 22. Contracts... or statements to stockholders 5 years. 2. Organizational documents: (a) Minute books of...

  14. 48 CFR 252.225-7012 - Preference for certain domestic commodities.

    Science.gov (United States)

    2010-10-01

    ... Germany Greece Israel Italy Luxembourg Netherlands Norway Portugal Spain Sweden Switzerland Turkey United... Columbia, and outlying areas. (5) U.S.-flag vessel means a vessel of the United States or belonging to the... fabric in Federal Supply Group 83, Textile/leather/furs/apparel/findings/ tents/flags, or Federal...

  15. The Rocky Shore. A Learning Experience for Coastal and Oceanic Awareness Studies, No. 225. [Project COAST].

    Science.gov (United States)

    Delaware Univ., Newark. Coll. of Education.

    This unit is designed to be used by students in biology classes in secondary schools. Emphasized in the unit are coastal life zones, plants and animals that live in these areas, and factors influencing the lives of the organisms. Included in the unit are evaluation materials, instructional objectives, student background information, masters for…

  16. A continuum damage analysis of hydrogen attack in 2.25 Cr-1Mo vessel

    DEFF Research Database (Denmark)

    van der Burg, M.W.D.; van der Giessen, E.; Tvergaard, Viggo

    1998-01-01

    reaction of carbides with hydrogen, thus forming cavities with high pressure methane gas. Driven by the methane gas pressure, the cavities grow, while remote tensile stresses can significantly enhance the cavitation rate. The damage model gives the strain-rate and damage rate as a function...... and later decelerate the cavitation rate significantly. Numerical studies for different material parameters and different stress conditions demonstrate the HA process inside a vessel in time. Also, the lifetime of the pressure vessel is determined. The analyses underline that the general applicability...

  17. 12 CFR 225.26 - Factors considered in acting on nonbanking proposals.

    Science.gov (United States)

    2010-01-01

    ... unfair competition, conflicts of interest, and unsound banking practices). (b) Financial and managerial resources. Consideration of the factors in paragraph (a) of this section includes an evaluation of...

  18. 12 CFR Appendix C to Part 225 - Small Bank Holding Company Policy Statement

    Science.gov (United States)

    2010-01-01

    ... provided they comply with the requirements set forth above. 3. Core Requirements for All Applicants In... strain on the resources of the bank(s), and the record and competency of management. In addition, the... policy statement, the bank holding company meets the core requirements for all applicants noted...

  19. 12 CFR 225.16 - Public notice, comments, hearings, and other provisions governing applications and notices.

    Science.gov (United States)

    2010-01-01

    ... calendar days. (iii) Joint requests by interested person and acquiring company. The Board will grant a joint request by an interested person and the acquiring bank holding company for an extension of the... (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  20. 48 CFR 3052.225-70 - Requirement for Use of Certain Domestic Commodities.

    Science.gov (United States)

    2010-10-01

    ... associated with, clothing and the materials and components thereof; or (2) Tents, tarpaulins, covers, textile... products. (2) Woven silk or woven silk blends. (3) Spun silk yarn for cartridge cloth. (4) Synthetic fabric or coated synthetic fabric (including all textile fibers and yarns that are for use in such...

  1. N-{2-[2-(5-Methyl-1H-pyrazol-3-ylacetamido]phenyl}benzamide monohydrate

    Directory of Open Access Journals (Sweden)

    Karim Chkirate

    2017-02-01

    Full Text Available The asymmetric unit of the title compound, C19H18N4O2·H2O, comprises the U-shaped pyrazole derivative and a solvent water molecule. The molecular conformation is partly determined by an intramolecular N—H...O hydrogen bond. The crystal packing is directed by an extensive network of O—H...O, N—H...O, N—H...N and C—H...O hydrogen bonds together with C—H...π(ring contacts that generate a three-dimensional network.

  2. 12 CFR 225.86 - What activities are permissible for any financial holding company?

    Science.gov (United States)

    2010-01-01

    ..., 84 Federal Reserve Bulletin 680 (1998)); (ii) Owning shares of a securities exchange (J.P. Morgan... depository institutions and their affiliates for use in the ordinary course of business (Norwest Corporation... exclusive. (A) Hosting an electronic marketplace on the financial holding company's Internet web site...

  3. 48 CFR 225.401-70 - End products subject to trade agreements.

    Science.gov (United States)

    2010-10-01

    ... Federal supply groups (FSG) are covered by trade agreements if the value of the acquisition is at or above... Materials handling equipment 40 Rope, cable, chain and fittings 41 Refrigeration and air conditioning... Medical, dental, and veterinary equipment and supplies 66 Instruments and laboratory equipment...

  4. 针灸补肾温阳法治疗女性尿道综合征225例%Treatment of 225 Cases of Female Urethral Syndrome with Acupuncture and Moxibustion Therapy for Tonifying Kidney and Warming Yang

    Institute of Scientific and Technical Information of China (English)

    郑蕙田; 赵光; 梁慧丽; 康培英; 崔金秀; 康云兰; 陆善娟; 黄红; 袁顺兴; 朱燕文; 陈文娟; 朱捷; 关建敏; 樊芳玲; 俞兰英; 朱明丽

    2000-01-01

    针灸取气海、关元、水道、命门、肾俞、气海俞等穴治疗,结果近期治愈65例(28.9%),显效76例(33.8%),有效59例(26.2%),无效25例(11.1%),总有效率为88.9%.其中尿频、尿急、小腹坠胀、排尿不尽等症状和对生活质量评估都有明显改善(P<0.001).

  5. 12 CFR Appendix A to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Risk-Based Measure

    Science.gov (United States)

    2010-01-01

    ... (that is, the excess, if any, of the fair value over historical cost) on available-for-sale equity... a paper prepared by the BSC entitled “International Convergence of Capital Measurement,” July 1988... represents the excess of the cost of an acquired entity over the net of the amounts assigned to...

  6. 12 CFR Appendix E to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Market Risk Measure

    Science.gov (United States)

    2010-01-01

    ... organization may apply a 2.0 percent risk weighting factor to the futures and stock basket positions (long and... intermediate-term preferred stock and related surplus) included in Tier 2 capital (both allocated and excess... organization to use alternative techniques to measure the market risk of de minimis exposures so long as...

  7. Deep-sea scleractinian coral age and depth distributions in the northwest Atlantic for the last 225,000 years

    Science.gov (United States)

    Robinson, L.F.; Adkins, J.F.; Scheirer, D.S.; Fernandez, D.P.; Gagnon, A.; Waller, R.G.

    2007-01-01

    Deep-sea corals have grown for over 200,000 yrs on the New England Seamounts in the northwest Atlantic, and this paper describes their distribution both with respect to depth and time. Many thousands of fossil scleractinian corals were collected on a series of cruises from 2003-2005; by contrast, live ones were scarce. On these seamounts, the depth distribution of fossil Desmophyllum dianthus (Esper, 1794) is markedly different to that of the colonial scleractinian corals, extending 750 m deeper in the water column to a distinct cut-off at 2500 m. This cut-off is likely to be controlled by the maximum depth of a notch-shaped feature in the seamount morphology. The ages of D. dianthus corals as determined by U-series measurements range from modern to older than 200,000 yrs. The age distribution is not constant over time, and most corals have ages from the last glacial period. Within the glacial period, increases in coral population density at Muir and Manning Seamounts coincided with times at which large-scale ocean circulation changes have been documented in the deep North Atlantic. Ocean circulation changes have an effect on coral distributions, but the cause of the link is not known. ?? 2007 Rosenstiel School of Marine and Atmospheric Science of the University of Miami.

  8. A continuum damage analysis of hydrogen attack in a 2.25Cr–1Mo pressure vessel

    NARCIS (Netherlands)

    Burg, M.W.D. van der; Giessen, E. van der; Tvergaard, V.

    1998-01-01

    A micromechanically based continuum damage model is presented to analyze the stress, temperature and hydrogen pressure dependent material degradation process termed hydrogen attack, inside a pressure vessel. Hydrogen attack (HA) is the damage process of grain boundary facets due to a chemical reacti

  9. 75 FR 79312 - Special Conditions: Eurocopter France (ECF) Model EC225LP Helicopter, Installation of a Search...

    Science.gov (United States)

    2010-12-20

    ... it plainly visible to and usable by any pilot at their station. (4) A system providing the aircraft longitudinal and lateral ground speeds and the pilot-selected longitudinal and lateral ground speeds when...

  10. 48 CFR 252.225-7035 - Buy American Act-Free Trade Agreements-Balance of Payments Program Certificate.

    Science.gov (United States)

    2010-10-01

    ... Item Number)(Country of Origin) (iii) The following supplies are other foreign end products, including... definition of “domestic end product”: (Line Item Number) (Country of Origin (If known)) (End of provision...,” “component,” “domestic end product,” “Free Trade Agreement country,” “Free Trade Agreement country...

  11. 48 CFR 52.225-4 - Buy American Act-Free Trade Agreement-Israeli Trade Act Certificate.

    Science.gov (United States)

    2010-10-01

    .... Country ofOrigin (c) The offeror shall list those supplies that are foreign end products (other than those... definition of “domestic end product.” Other Foreign End Products: LINE ITEM NO. COUNTRY OF ORIGIN... product,” “foreign end product,” “Free Trade Agreement country,” “Free Trade Agreement country end......

  12. 12 CFR Appendix G to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Internal-Ratings-Based and Advanced...

    Science.gov (United States)

    2010-01-01

    ... Supervision's “International Convergence of Capital Measurement and Capital Standards: A Revised Framework” in... instrument described in paragraph (1) of this definition. Excess spread for a period means: (1) Gross...

  13. 32 CFR 37.225 - What judgment must I make about the benefits of using a TIA?

    Science.gov (United States)

    2010-07-01

    ... DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Appropriate Use of Technology... cooperative agreement subject to all of the requirements of 32 CFR part 34). You, in conjunction with... of a TIA permit the involvement in the research of any commercial firms or business units of...

  14. 77 FR 60883 - Special Conditions: Eurocopter France (ECF) Model EC225LP Helicopter, Installation of a Search...

    Science.gov (United States)

    2012-10-05

    ... of a Search and Rescue (SAR) Automatic Flight Control System (AFCS) AGENCY: Federal Aviation... / Friday, October 5, 2012 / Rules and Regulations#0;#0; ] DEPARTMENT OF TRANSPORTATION Federal Aviation...-01; Sec. 29.807(d)(2), Ditching emergency exits for passengers. (7) TC2899RD-R-P-01; Sec....

  15. 225-255-GHz InP DHBT Frequency Tripler MMIC Using Complementary Split-Ring Resonator

    Science.gov (United States)

    Li, Xiao; Zhang, Yong; Li, Oupeng; Sun, Yan; Lu, Haiyan; Cheng, Wei; Xu, Ruimin

    2017-02-01

    In this paper, a novel design of frequency tripler monolithic microwave integrated circuit (MMIC) using complementary split-ring resonator (CSRR) is proposed based on 0.5-μm InP DHBT process. The CSRR-loaded microstrip structure is integrated in the tripler as a part of impedance matching network to suppress the fundamental harmonic, and another frequency tripler based on conventional band-pass filter is presented for comparison. The frequency tripler based on CSRR-loaded microstrip generates an output power between -8 and -4 dBm from 228 to 255 GHz when the input power is 6 dBm. The suppression of fundamental harmonic is better than 20 dBc at 77-82 GHz input frequency within only 0.15 × 0.15 mm2 chip area of the CSRR structure on the ground layer. Compared with the frequency tripler based on band-pass filter, the tripler using CSRR-loaded microstrip obtains a similar suppression level of unwanted harmonics and higher conversion gain within a much smaller chip area. To our best knowledge, it is the first time that CSRR is used for harmonic suppression of frequency multiplier at such high frequency band.

  16. 48 CFR 52.225-19 - Contractor Personnel in a Designated Operational Area or Supporting a Diplomatic or Consular...

    Science.gov (United States)

    2010-10-01

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  20. A 225 kW Direct Driven PM Generator Adapted to a Vertical Axis Wind Turbine

    Directory of Open Access Journals (Sweden)

    S. Eriksson

    2011-01-01

    Full Text Available A unique direct driven permanent magnet synchronous generator has been designed and constructed. Results from simulations as well as from the first experimental tests are presented. The generator has been specifically designed to be directly driven by a vertical axis wind turbine and has an unusually low reactance. Generators for wind turbines with full variable speed should maintain a high efficiency for the whole operational regime. Furthermore, for this application, requirements are placed on high generator torque capability for the whole operational regime. These issues are elaborated in the paper and studied through simulations. It is shown that the generator fulfils the expectations. An electrical control can effectively substitute a mechanical pitch control. Furthermore, results from measurements of magnetic flux density in the airgap and no load voltage coincide with simulations. The electromagnetic simulations of the generator are performed by using an electromagnetic model solved in a finite element environment.