WorldWideScience

Sample records for actinium 225

  1. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    International Nuclear Information System (INIS)

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  2. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  3. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  4. New method for large scale production of medically applicable Actinium-225 and Radium-223

    International Nuclear Information System (INIS)

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  5. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  6. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the

  7. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  8. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  9. Spectroscopic and computational investigation of actinium coordination chemistry.

    Science.gov (United States)

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  10. Separation of Actinium 227 from the uranium minerals

    International Nuclear Information System (INIS)

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  11. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  12. BEH 225 Tutorials /beh225dotcom

    OpenAIRE

    veena022

    2015-01-01

    BEH 225 Entire Course For more course tutorials visit www.beh225.com   BEH 225 Week 1 CheckPointResearch Methods BEH 225 Week 1 DQ 1 and DQ 2 BEH 225 Week 2 CheckPointHeredity and Hormones BEH 225 Week 2 AssignmentBrain Response of Behavior BEH 225 Week 3 CheckPointIntelligence Presentation BEH 225 Week 3 DQ 1 and DQ 2 BEH 225 Week 4 CheckPointSkinner Article BEH 225 Week 4 AssignmentProblem-Solving Simulation BEH 225 Week 5 CheckPointMotiv...

  13. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  14. ADJ 225 Courses Tutorial / indigohelp

    OpenAIRE

    nesa

    2015-01-01

    ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint Community Agency Goals ADJ 225 CheckPoint 1 Juvenile Court Characteristics ADJ 2...

  15. ENG 225 ASH Course Tutorial / eng225dotcom

    OpenAIRE

    anil27

    2015-01-01

    ENG 225 Entire Course (Ash) For more course tutorials visit www.eng225.com   ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Cri...

  16. ENG 225 ASH Material-eng225dotcom

    OpenAIRE

    Sandywilliam1

    2015-01-01

    ENG 225 Entire Course (Ash) For more course tutorials visit www.eng225.com   ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Cri...

  17. ADJ 225 Course Tutorial / tutorialrank

    OpenAIRE

    welcome1365

    2015-01-01

    ADJ 225 Entire Course For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 1 Times, Rating: A+     ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ...

  18. ADJ 225 Courses/snaptutorial

    OpenAIRE

    charles

    2015-01-01

    ­For more classes visits www.snaptutorial.com                 ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ ...

  19. BEH 225 Course tutorial/ indigohelp

    OpenAIRE

    AcSCCSA

    2015-01-01

    For more classes visit www.indigohelp.com   BEH 225 Week 1 CheckPointResearch Methods BEH 225 Week 1 DQ 1 and DQ 2 BEH 225 Week 2 CheckPoint Heredity and Hormones BEH 225 Week 2 Assignment Brain Response of Behavior BEH 225 Week 3 CheckPoint Intelligence Presentation BEH 225 Week 3 DQ 1 and DQ 2 BEH 225 Week 4 CheckPoint Skinner Article BEH 225 Week 4 AssignmentProblem-Solving Simulation BEH 225 Week 5 CheckPoint Motivating Employees BEH 22...

  20. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    International Nuclear Information System (INIS)

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  1. ADJ 225 UOP COURSE Tutorial/UOPHELP

    OpenAIRE

    mangush

    2015-01-01

    For more course tutorials visit www.uophelp.com       ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint...

  2. ENG 225 UOP COURSE Tutorial/UOPHELP

    OpenAIRE

    dfvgbnm,m

    2015-01-01

    For more course tutorials visit www.uophelp.com   ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Critique Draft ENG 225 Week 3 Q...

  3. ENG 225(ASH) course tutorial/tutorialoutlet

    OpenAIRE

    NARESH 1

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com     ENG 225 Week 1 DQ 1 An Evolving Industry ENG 225 Week 1 DQ 2 Narrative and Storytelling ENG 225 Week 1 Quiz ENG 225 Week 2 DQ 1 Actors and Acting ENG 225 Week 2 DQ 2 Tools of Cinematography ENG 225 Week 2 Assignment Elements of Design ENG 225 Week 2 Quiz ENG 225 Week 3 DQ 1 Frame by Frame ENG 225 Week 3 DQ 2 Music and Soundscapes ENG 225 Week 3 Assignment Final Film Critique Draft ...

  4. ADJ 225 UOP Course Tutorial / Tutorialrank

    OpenAIRE

    charles

    2015-01-01

    For more course tutorials visit www.tutorialrank.com ADJ 225 Assignment Corrections Comparison Summary (UOP) ADJ 225 Assignment Final Project(UOP) ADJ 225 Assignment Juvenile Court Comparison(UOP) ADJ 225 CheckPoint Juvenile Offenders(UOP) ADJ 225 Assignment Risk Factor Handout(UOP) ADJ 225 CheckPoint 1 Juvenile Court Characteristics(UOP) ADJ 225 CheckPoint 2 Mission Statement(UOP) ADJ 225 CheckPoint Case Study Sequence(UOP) ADJ 225 CheckPoint Community Agency ...

  5. BEH 225 UOP course/uophelp

    OpenAIRE

    uophelp

    2015-01-01

    For more course tutorials visit www.uophelp.com   BEH 225 Week 1 CheckPointResearch Methods BEH 225 Week 1 DQ 1 and DQ 2 BEH 225 Week 2 CheckPoint Heredity and Hormones BEH 225 Week 2 Assignment Brain Response of Behavior BEH 225 Week 3 CheckPoint Intelligence Presentation BEH 225 Week 3 DQ 1 and DQ 2 BEH 225 Week 4 CheckPoint Skinner Article BEH 225 Week 4 AssignmentProblem-Solving Simulation BEH 225 Week 5 CheckPoint Motivating Employees ...

  6. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Science.gov (United States)

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  7. Ac, La, and Ce radioimpurities in {sup 225}Ac produced in 40-200 MeV proton irradiations of thorium

    Energy Technology Data Exchange (ETDEWEB)

    Engle, Jonathan W.; Ballard, Beau D. [Los Alamos National Laboratory, NM (United States); Weidner, John W. [Air Force Institute of Technology, Wright Patterson Air Force Base, OH (United States); and others

    2014-10-01

    Accelerator production of {sup 225}Ac addresses the global supply deficiency currently inhibiting clinical trials from establishing {sup 225}Ac's therapeutic utility, provided that the accelerator product is of sufficient radionuclidic purity for patient use. Two proton activation experiments utilizing the stacked foil technique between 40 and 200 MeV were employed to study the likely co-formation of radionuclides expected to be especially challenging to separate from {sup 225}Ac. Foils were assayed by nondestructive γ-spectroscopy and by α-spectroscopy of chemically processed target material. Nuclear formation cross sections for the radionuclides {sup 226}Ac and {sup 227}Ac as well as lower lanthanide radioisotopes {sup 139}Ce, {sup 141}Ce, {sup 143}Ce, and {sup 140}La whose elemental ionic radii closely match that of actinium were measured and are reported. The predictions of the latest MCNP6 event generators are compared with measured data, as they permit estimation of the formation rates of other radionuclides whose decay emissions are not clearly discerned in the complex spectra collected from {sup 232}Th(p,x) fission product mixtures. (orig.)

  8. ADJ 225 uop course tutorial/uop help

    OpenAIRE

    sando

    2015-01-01

    For more course tutorials visit www.uophelp.com       ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint...

  9. ADJ 225 UOP Course Tutorial/TutotorialRank

    OpenAIRE

    hidden

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 3 Times, Rating: A+ ADJ 225 Assignment Corrections Comparison Summary  ADJ 225 Assignment Final Project ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Risk Factor Handout ADJ 225 CheckPoint 1 Juvenile Court Characteristics ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Case Study Sequence ADJ 225 CheckPoint Community Agency Goals ADJ 225 CheckPoint Juveni...

  10. 40 CFR 46.225 - Equipment.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Equipment. 46.225 Section 46.225... After the Fellowship § 46.225 Equipment. (a) If EPA authorizes you to purchase equipment (see § 46.140(b)) and the equipment retains a fair market value of more than $5,000, you must request...

  11. 21 CFR 225.30 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.30 Section 225.30 Food and Drugs... Equipment § 225.30 Equipment. (a) Equipment which is designed to perform its intended function and is properly installed and used is essential to the manufacture of medicated feeds. Such equipment...

  12. 21 CFR 225.130 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment. 225.130 Section 225.130 Food and Drugs... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Facilities and Equipment § 225.130 Equipment. Equipment shall be capable of producing a medicated feed of intended potency and purity, and shall...

  13. 49 CFR 397.225 - Judicial review.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Judicial review. 397.225 Section 397.225... MATERIALS; DRIVING AND PARKING RULES Preemption Procedures § 397.225 Judicial review. A party to a proceeding under § 397.205(a), § 397.213(a), or § 397.223(a) may seek review by the appropriate...

  14. 10 CFR 600.225 - Program income.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Program income. 600.225 Section 600.225 Energy DEPARTMENT....225 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees for services performed, from the use or rental of real...

  15. 12 CFR 225.65 - Appraiser independence.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Appraiser independence. 225.65 Section 225.65 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... Federally Related Transactions § 225.65 Appraiser independence. (a) Staff appraisers. If an appraisal...

  16. 21 CFR 225.42 - Components.

    Science.gov (United States)

    2010-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Control § 225.42 Components. (a) A... inventory control for all such drugs to aid in assuring their identity, strength, quality, and purity when... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Components. 225.42 Section 225.42 Food and...

  17. 45 CFR 225.1 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Definitions. 225.1 Section 225.1 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR... VOLUNTEERS § 225.1 Definitions. (a) The classification of subprofessional staff as community service...

  18. 7 CFR 225.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... (7 CFR part 15) issued under title VI of the Civil Rights Act of 1964, and any Instructions issued by... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 225.3 Section 225.3 Agriculture... CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM General § 225.3 Administration. (a)...

  19. 49 CFR 238.225 - Electrical system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Electrical system. 238.225 Section 238.225... Equipment § 238.225 Electrical system. All passenger equipment shall comply with the following: (a... produce electrical noise that affects the safe performance of train line control and communications...

  20. 12 CFR 225.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... Regarding Delegation of Authority (12 CFR part 265) and the Board's Rules of Procedure (12 CFR part 262). (b... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Administration. 225.3 Section 225.3 Banks and... COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General Provisions § 225.3...

  1. ADJ 225 UOP Course Tutorial/TutorialRank

    OpenAIRE

    apj

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 1 Times, Rating: A+   ADJ 225 Assignment Final Project ADJ 225 Week 8 Assignment Prevention Program Resource Guides- Appendix F ADJ 225 CheckPoint 2 Mission Statement ADJ 225 CheckPoint Levels of Prevention ADJ 225 Assignment Juvenile Court Comparison ADJ 225 Assignment Corrections Comparison Summary ADJ 225 CheckPoint Case Study Sequence ADJ 225 Assignment Risk Factor Han...

  2. Octupole correlations in 225Th

    International Nuclear Information System (INIS)

    The nuclear structure of 225Th has been studied using the reaction 226Ra(α, 5n)225Th at a beam energy of 50 MeV. In-beam γγ, e-e-, e-n and e-γ coincidences have been measured, along with γ-ray and electron intensities, and these have been used to establish a decay scheme up to spin 39/2 ℎ and excitation energy 2494 keV. Parity doublets have been observed, forming two 'quasi-molecular bands', along with enhanced E1 transitions linking states of opposite parity. γ-branching ratios have been measured and an average value of vertical strokeD0/Q0vertical stroke=(0.51±0.06)x10-3 fm-1 has been deduced. The results are compared with calculations incorporating odd multipole degrees of freedom in the description of the nuclear shape. (orig.)

  3. DNA double strand breaks as predictor of efficacy of the alpha-particle emitter Ac-225 and the electron emitter Lu-177 for somatostatin receptor targeted radiotherapy.

    Directory of Open Access Journals (Sweden)

    Franziska Graf

    Full Text Available RATIONALE: Key biologic effects of the alpha-particle emitter Actinium-225 in comparison to the beta-particle emitter Lutetium-177 labeled somatostatin-analogue DOTATOC in vitro and in vivo were studied to evaluate the significance of γH2AX-foci formation. METHODS: To determine the relative biological effectiveness (RBE between the two isotopes (as - biological consequence of different ionisation-densities along a particle-track, somatostatin expressing AR42J cells were incubated with Ac-225-DOTATOC and Lu-177-DOTATOC up to 48 h and viability was analyzed using the MTT assay. DNA double strand breaks (DSB were quantified by immunofluorescence staining of γH2AX-foci. Cell cycle was analyzed by flow cytometry. In vivo uptake of both radiolabeled somatostatin-analogues into subcutaneously growing AR42J tumors and the number of cells displaying γH2AX-foci were measured. Therapeutic efficacy was assayed by monitoring tumor growth after treatment with activities estimated from in vitro cytotoxicity. RESULTS: Ac-225-DOTATOC resulted in ED50 values of 14 kBq/ml after 48 h, whereas Lu-177-DOTATOC displayed ED50 values of 10 MBq/ml. The number of DSB grew with increasing concentration of Ac-225-DOTATOC and similarly with Lu-177-DOTATOC when applying a factor of 700-fold higher activity compared to Ac-225. Already 24 h after incubation with 2.5-10 kBq/ml, Ac-225-DOTATOC cell-cycle studies showed up to a 60% increase in the percentage of tumor cells in G2/M phase. After 72 h an apoptotic subG1 peak was also detectable. Tumor uptake for both radio peptides at 48 h was identical (7.5%ID/g, though the overall number of cells with γH2AX-foci was higher in tumors treated with 48 kBq Ac-225-DOTATOC compared to tumors treated with 30 MBq Lu-177-DOTATOC (35% vs. 21%. Tumors with a volume of 0.34 ml reached delayed exponential tumor growth after 25 days (44 kBq Ac-225-DOTATOC and after 21 days (34 MBq Lu-177-DOTATOC. CONCLUSION: γH2AX-foci formation, triggered

  4. 18 CFR 225.2 - General instructions.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false General instructions. 225.2 Section 225.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... betterments thereto must be retained until the Commission has determined the actual legitimate original...

  5. 31 CFR 800.225 - United States.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States. 800.225 Section 800... TAKEOVERS BY FOREIGN PERSONS Definitions § 800.225 United States. The term United States or U.S. means the United States of America, the States of the United States, the District of Columbia, and any...

  6. 24 CFR 990.225 - Transition determination.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Transition determination. 990.225 Section 990.225 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT THE PUBLIC HOUSING OPERATING...

  7. 48 CFR 225.7501 - Policy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Policy. 225.7501 Section... DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Balance of Payments Program 225.7501 Policy. Acquire... Materiel Board; or (vi) Information technology that is a commercial item, using fiscal year 2004...

  8. 21 CFR 225.58 - Laboratory controls.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory controls. 225.58 Section 225.58 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Product Quality Control §...

  9. 12 CFR 225.177 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Definitions. 225.177 Section 225.177 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Merchant Banking Investments §...

  10. 40 CFR 86.225-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false 86.225-94 Section 86.225-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty...

  11. 25 CFR 225.2 - Information collection.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Information collection. 225.2 Section 225.2 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND... require review under the Paperwork Reduction Act (44 U.S.C. 3501 et seq.)....

  12. 48 CFR 225.104 - Nonavailable articles.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Nonavailable articles. 225.104 Section 225.104 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Nonavailable articles. (a) DoD has determined that the following articles also are nonavailable in...

  13. 22 CFR 225.114 - Cooperative research.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Cooperative research. 225.114 Section 225.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible...

  14. 44 CFR 206.225 - Emergency work.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Emergency work. 206.225 Section 206.225 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... that a threat exists, including identification and evaluation of the threat and recommendations of...

  15. Dicty_cDB: SSI225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSI225 (Link to dictyBase) - - - Contig-U12571-1 SSI225E (Link... to Original site) - - - - - - SSI225E 293 Show SSI225 Library SS (Link to library) Clone ID SSI225 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSI2-B/SSI225Q.Seq.d/ Representative seq. ID SSI22...5E (Link to Original site) Representative DNA sequence >SSI225 (SSI225Q) /CSM/SS/SSI2-B/SSI225Q.Seq.d/ CTTTA...irkkk*e Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSI225 (SSI

  16. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    International Nuclear Information System (INIS)

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  17. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  18. 48 CFR 225.871-3 - General.

    Science.gov (United States)

    2010-10-01

    ... implement cooperative projects. (b) Contracts implementing cooperative projects shall comply with all... DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Other International Agreements and Coordination 225.871-3 General. (a) Cooperative project authority. (1) Departments and agencies, that have authority...

  19. Cyclotron and linac production of Ac-225.

    Science.gov (United States)

    Melville, Graeme; Allen, Barry J

    2009-04-01

    Radium needles that were once implanted into tumours as a cancer treatment are now obsolete and constitute a radioactive waste problem, as their half-life is 1600 years. The reduction of radium by photonuclear transmutation by bombarding Ra-226 with high-energy photons from a medical linear accelerator (linac) has been investigated. A linac dose of 2800 Gy produced about 2.4 MBq (64 microCi) of Ra-225, which decays to Ac-225 and can then be used for 'Targeted Alpha Therapy' (TAT) of cancer. This result, while consistent with theoretical calculations, is far too low to be of practical use unless much larger quantities of radium are irradiated. The increasing application of Ac-225 for cancer therapy indicates the potential need for its increased production and availability. This paper investigates the possibility of producing of Ac-225 in commercial quantities, which could potentially reduce obsolete radioactive material and displace the need for expensive importation of Ac-225 from the USA and Russia in the years ahead. Scaled up production of Ac-225 could theoretically be achieved by the use of a high current cyclotron or linac. Production specifications are determined for a linac in terms of current, pulse length and frequency, as well as an examination of other factors such as radiation issues and radionuclei separation. Yields are compared with those calculated for the Australian National Cyclotron in Sydney.

  20. Dicty_cDB: CHR225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR225 (Link to dictyBase) - - - Contig-U11316-1 - (Link to Original site) - - CHR...225Z 621 - - - - Show CHR225 Library CH (Link to library) Clone ID CHR225 (Link to dicty...iol.tsukuba.ac.jp/CSM/CH/CHR2-B/CHR225Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >CHR225 (CHR225Q) /CSM/CH/CHR2-B/CHR225Q.Seq.d/ XXXXXXXXXXTTAGCTC... CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CHR225 (CHR225Q) /CSM/CH/CHR2-B/CHR

  1. 12 CFR 225.62 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... Transactions § 225.62 Definitions. (a) Appraisal means a written statement independently and impartially... atypical. (f) Federally related transaction means any real estate-related financial transaction entered... their own best interests; (3) A reasonable time is allowed for exposure in the open market; (4)...

  2. 7 CFR 225.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM General § 225.2 Definitions. Act means the National.... Adult means, for the purposes of the collection of social security numbers as a condition of...

  3. 21 CFR 225.80 - Labeling.

    Science.gov (United States)

    2010-04-01

    ... CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS Packaging and Labeling § 225.80 Labeling. (a... adhered to, will assure that the article is safe and effective for its intended purposes. (b)(1) Labels... medicated feed and includes adequate information for the safe and effective use of the medicated feed....

  4. 49 CFR 225.25 - Recordkeeping.

    Science.gov (United States)

    2010-10-01

    ... and policies, e.g., the policy statement in the internal control plan required by § 225.33 concerning... days; beginning date; (iii) Occupational illness; date of initial diagnosis; (iv) Instructions to... recognizes that circumstances outside the railroad's control may preclude it from fulfilling the...

  5. 48 CFR 225.872-6 - Audit.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Audit. 225.872-6 Section...-6 Audit. (a) Memoranda of understanding with some qualifying countries contain annexes that provide for reciprocal “no-cost” audits of contracts and subcontracts (pre- and post-award). (b) To...

  6. 48 CFR 225.7012 - Restriction on supercomputers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on supercomputers. 225.7012 Section 225.7012 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... supercomputers....

  7. 12 CFR 225.125 - Investment adviser activities.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Investment adviser activities. 225.125 Section 225.125 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE... Companies Interpretations § 225.125 Investment adviser activities. (a) Effective February 1, 1972, the...

  8. 12 CFR 225.131 - Activities closely related to banking.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.131 Section 225.131 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.131 Activities closely related to banking. (a) Bank...

  9. 12 CFR 225.129 - Activities closely related to banking.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.129 Section 225.129 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.129 Activities closely related to banking. Courier activities....

  10. 12 CFR 225.123 - Activities closely related to banking.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities closely related to banking. 225.123 Section 225.123 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... Holding Companies Interpretations § 225.123 Activities closely related to banking. (a) Effective June...

  11. 25 CFR 225.26 - Auditing and accounting.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Auditing and accounting. 225.26 Section 225.26 Indians... SOLID MINERALS AGREEMENTS Minerals Agreements § 225.26 Auditing and accounting. The Secretary may... agreement. Procedures and standards used for accounting and auditing of minerals agreements will be...

  12. 45 CFR 225.2 - State plan requirements.

    Science.gov (United States)

    2010-10-01

    ... personnel of which subprofessional staff are an integral part; (3) A career service plan permitting persons... 45 Public Welfare 2 2010-10-01 2010-10-01 false State plan requirements. 225.2 Section 225.2... SUBPROFESSIONALS AND VOLUNTEERS § 225.2 State plan requirements. The State plan for financial assistance...

  13. 12 CFR 225.44 - Reporting of stock loans.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Reporting of stock loans. 225.44 Section 225.44... § 225.44 Reporting of stock loans. (a) Requirements. (1) Any foreign bank or affiliate of a foreign bank... involves a person or group of persons that has been the owner or owners of record of the stock for a...

  14. 29 CFR 22.5 - Review by the reviewing official.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Review by the reviewing official. 22.5 Section 22.5 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.5 Review by the reviewing official. (a) If, based on the report of the investigating official under § 22.4(b), the reviewing...

  15. Improved limit on the $^{225}$Ra electric dipole moment

    OpenAIRE

    Bishof, Michael; Parker, Richard H.; Bailey, Kevin G.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Singh, Jaideep T.; Dietrich, Matthew R.

    2016-01-01

    Background: Octupole-deformed nuclei, such as that of $^{225}$Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015, we reported the first "proof-of-principle" measurement of the $^{225}$Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our $^{225}$Ra EDM measurements by orders of magnitude and eva...

  16. 49 CFR 225.33 - Internal Control Plans.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Internal Control Plans. 225.33 Section 225.33....33 Internal Control Plans. (a) Each railroad shall adopt and comply with a written Internal Control... official business. Each railroad shall amend its Internal Control Plan, as necessary, to reflect...

  17. 40 CFR 225.4 - Waiver by Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Waiver by Administrator. 225.4 Section... ENGINEERS DREDGED MATERIAL PERMITS § 225.4 Waiver by Administrator. The Administrator shall grant the... (including spawning and breeding areas), wildlife, or recreational areas. Notice of the Administrator's...

  18. 7 CFR 225.8 - Records and reports.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Records and reports. 225.8 Section 225.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... whether the site is rural or urban, or vended or self-preparation....

  19. 29 CFR 778.225 - Talent fees excludable under regulations.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Talent fees excludable under regulations. 778.225 Section 778.225 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION Payments That May Be Excluded From...

  20. 14 CFR 417.225 - Debris risk analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Debris risk analysis. 417.225 Section 417... OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.225 Debris risk analysis. A flight safety analysis must demonstrate that the risk to the public potentially exposed to inert...

  1. 48 CFR 252.225-7041 - Correspondence in English.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Correspondence in English... of Provisions And Clauses 252.225-7041 Correspondence in English. As prescribed in 225.1103(2), use the following clause: Correspondence in English (JUN 1997) The Contractor shall ensure that...

  2. 7 CFR 225.14 - Requirements for sponsor participation.

    Science.gov (United States)

    2010-01-01

    ... 225.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM Sponsor and Site Provisions... Youth Sports Program; and (5) Private nonprofit organizations as defined in § 225.2. (c)...

  3. 12 CFR 225.124 - Foreign bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1, 1971,...

  4. 7 CFR 1280.225 - Books and records of persons.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Books and records of persons. 1280.225 Section 1280.225 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE...

  5. 25 CFR 225.22 - Approval of minerals agreements.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Approval of minerals agreements. 225.22 Section 225.22 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL... with written findings forming the basis of the Secretary's intent to approve or disapprove the...

  6. 14 CFR 93.225 - Lottery of available slots.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Lottery of available slots. 93.225 Section... Carrier IFR Operations at High Density Traffic Airports § 93.225 Lottery of available slots. (a) Whenever... shall be allocated in accordance with the provisions of this section. (b) A random lottery shall be...

  7. 12 CFR 225.132 - Acquisition of assets.

    Science.gov (United States)

    2010-01-01

    ... Companies Interpretations § 225.132 Acquisition of assets. (a) From time to time questions have arisen as to... the Board's Regulation Y (12 CFR 225.4(c)(3)) generally prohibits a bank holding company or its... any merger “or acquisition of assets other than in the ordinary course of business” without...

  8. 22 CFR 225.112 - Review by institution.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Review by institution. 225.112 Section 225.112... institution. Research covered by this policy that has been approved by an IRB may be subject to further appropriate review and approval or disapproval by officials of the institution. However, those officials...

  9. 21 CFR 225.1 - Current good manufacturing practice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Current good manufacturing practice. 225.1 Section...) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR MEDICATED FEEDS General Provisions § 225.1 Current good manufacturing practice. (a) Section 501(a)(2)(B) of the Federal Food, Drug, and Cosmetic...

  10. 48 CFR 225.870-8 - Industrial security.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial security. 225... Coordination 225.870-8 Industrial security. Industrial security for Canada shall be in accordance with the U.S.-Canada Industrial Security Agreement of March 31, 1952, as amended....

  11. 5 CFR 591.225 - Which CPIs does OPM use?

    Science.gov (United States)

    2010-01-01

    ... Allowances § 591.225 Which CPIs does OPM use? OPM uses the following CPIs: (a) For the Washington, DC, area—the BLS Consumer Price Index, All Urban Consumers (CPI-U); (b) For all COLA areas in the State of... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Which CPIs does OPM use? 591.225...

  12. 14 CFR 121.225 - Propeller deicing fluid.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Propeller deicing fluid. 121.225 Section 121.225 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND...

  13. Cyclotron production of Ac-225 for targeted alpha therapy.

    Science.gov (United States)

    Apostolidis, C; Molinet, R; McGinley, J; Abbas, K; Möllenbeck, J; Morgenstern, A

    2005-03-01

    The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.

  14. 48 CFR 225.872-3 - Solicitation procedures.

    Science.gov (United States)

    2010-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Other International Agreements... Corporation in accordance with 225.870. (c) Use international air mail if solicitation destinations are... (Acquisition, Technology, and Logistics), before excluding the qualifying country source from consideration....

  15. 48 CFR 252.225-7008 - Restriction on Acquisition of Specialty Metals.

    Science.gov (United States)

    2010-10-01

    ... of Specialty Metals. 252.225-7008 Section 252.225-7008 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.225-7008 Restriction on Acquisition of Specialty Metals. As prescribed in 225.7003-5(a)(1), use the following clause: Restriction on Acquisition of Specialty Metals...

  16. 48 CFR 252.225-7011 - Restriction on acquisition of supercomputers.

    Science.gov (United States)

    2010-10-01

    ... of supercomputers. 252.225-7011 Section 252.225-7011 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.225-7011 Restriction on acquisition of supercomputers. As prescribed in 225.7012-3, use the following clause: Restriction on Acquisition of Supercomputers (JUN...

  17. Design and synthesis of {sup 225}Ac radioimmunopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    McDevitt, Michael R.; Ma, Dangshe; Simon, Jim; Frank, R. Keith; Scheinberg, David A. E-mail: d-scheinberg@ski.mskcc.org

    2002-12-01

    The alpha-particle-emitting radionuclides {sup 213}Bi, {sup 211}At, {sup 224}Ra are under investigation for the treatment of leukemias, gliomas, and ankylosing spondylitis, respectively. {sup 213}Bi and {sup 211}At were attached to monoclonal antibodies and used as targeted immunotherapeutic agents while unconjugated {sup 224}Ra chloride selectively seeks bone. {sup 225}Ac possesses favorable physical properties for radioimmunotherapy (10 d half-life and 4 net alpha particles), but has a history of unfavorable radiolabeling chemistry and poor metal-chelate stability. We selected functionalized derivatives of DOTA as the most promising to pursue from out of a group of potential {sup 225}Ac chelate compounds. A two-step synthetic process employing either MeO-DOTA-NCS or 2B-DOTA-NCS as the chelating moiety was developed to attach {sup 225}Ac to monoclonal antibodies. This method was tested using several different IgG systems. The chelation reaction yield in the first step was 93{+-}8% radiochemically pure (n=26). The second step yielded {sup 225}Ac-DOTA-IgG constructs that were 95{+-}5% radiochemically pure (n=27) and the mean percent immunoreactivity ranged from 25% to 81%, depending on the antibody used. This process has yielded several potential novel targeted {sup 225}Ac-labeled immunotherapeutic agents that may now be evaluated in appropriate model systems and ultimately in humans.

  18. Improved experimental limit on the EDM of 225Ra

    Science.gov (United States)

    Bishof, Michael; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Tom P.; Parker, Richard H.; Rabga, Tenzin; Singh, Jaideep T.

    2015-10-01

    Searches for permanent electric dipole moments (EDMs) in fundamental and composite particles are sensitive probes of beyond-standard-model symmetry violation that could explain the dominance of matter over anti-matter. The 225Ra (t1/2 = 15d, I = 1/2) atom is a particularly attractive system to use for an EDM measurement because its large nuclear octupole deformation, closely spaced ground-state parity doublet, and large atomic mass make 225Ra uniquely sensitive to symmetry-violating interactions in the nuclear medium. We have developed an experiment to measure the EDM of 225Ra and demonstrated the first ``proof-of-principle'' measurement, giving a 95% confidence upper limit of 5E-22 e-cm. After implementing a vacuum upgrade, we have observed nuclear spin coherence after 20 s of free evolution - a factor of ten improvement over our earlier results - and have lowered the 225Ra EDM limit by over an order of magnitude. Upcoming experimental upgrades have the potential to further improve our EDM sensitivity by many orders of magnitude, allowing us to test symmetry violation at an unprecedented level. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  19. 27 CFR 28.225 - Removals of beer by brewer.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removals of beer by brewer..., DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Exportation of Beer With Benefit of Drawback Execution of Claims § 28.225 Removals of beer by brewer. Where a brewer removes taxpaid beer from...

  20. 40 CFR 1065.225 - Intake-air flow meter.

    Science.gov (United States)

    2010-07-01

    ... CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments Flow-Related Measurements § 1065.225 Intake-air... § 1065.205. This may include a laminar flow element, an ultrasonic flow meter, a subsonic venturi, a... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Intake-air flow meter....

  1. 12 CFR 225.41 - Transactions requiring prior notice.

    Science.gov (United States)

    2010-01-01

    ... RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Change in Bank... or bank holding company, unless the acquisition is exempt under § 225.42. (b) Definitions. For... securities, or an increase in percentage ownership of a state member bank or a bank holding company...

  2. 20 CFR 637.225 - Determination of incentive bonus.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of incentive bonus. 637.225... of incentive bonus. The amount of the incentive bonus to be paid to each State shall be the total of the incentive bonuses claimed for each eligible individual within the State. The amount of...

  3. 48 CFR 225.7304 - FMS customer involvement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false FMS customer involvement... Military Sales 225.7304 FMS customer involvement. (a) FMS customers may request that a defense article or... contract without full and open competition. The FMS customer may also request that a subcontract be...

  4. 48 CFR 752.225-71 - Local procurement.

    Science.gov (United States)

    2010-10-01

    ... and nationality waivers as set forth in subpart F of 22 CFR part 228 except as provided for in 22 CFR... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Local procurement. 752.225... Local procurement. For use in any USAID contract involving performance overseas. Local Procurement...

  5. 40 CFR 98.225 - Procedures for estimating missing data.

    Science.gov (United States)

    2010-07-01

    ... PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Nitric Acid Production § 98.225 Procedures for estimating missing data. A complete record of all measured parameters used in the GHG emissions calculations..., including emission factors, production rate, and N2O concentration, you must conduct a new performance...

  6. 48 CFR 52.225-5 - Trade Agreements.

    Science.gov (United States)

    2010-10-01

    ... following: textiles and apparel articles; footwear, handbags, luggage, flat goods, work gloves, and leather... Agreement country (Aruba, Austria, Belgium, Bulgaria, Canada, Cyprus, Czech Republic, Denmark, Estonia... clause) Editorial Note: For Federal Register citations affecting § 52.225-5, see the List of CFR...

  7. Expert Consideration on the Amendment to the INFCIRC/225

    International Nuclear Information System (INIS)

    The INFCIRC/225 has played an important role as a guideline for establishing international regimes for physical protection since it was published in 1975 by the IAEA. It has been amended four times to reflect the changes that have taken place with regard to nuclear security. The fourth revision was released in 1999. Since the release of this revision, the international nuclear security environment has changed drastically. Because of the September 11, 2001 terrorist attacks in the USA, an amendment to the CPPNM (Convention on Physical Protection of Nuclear Material) was passed at an international conference held in July of 2005 in Vienna. Many requests for a revision of the INFCIRC/225 have been raised since then. The IAEA had prepared a revised document; and sponsored the first of six meetings in order to amendment the document beginning in February of 2008. A TM (Technical Meeting) was also held in February of 2010. Physical protection experts from 22 countries participated in the meeting. After the TM, a draft document was sent to member states for reviewed for a designated 120 days. If ratified, document will then become the 5th amendment to the INFCIRC/225. The INFCIRC/225 will be used as a basis for physical protection measures specified in the Act. This paper will analyze the revised document and discussed on how it affects our national regime of physical protection

  8. 40 CFR 225.3 - Procedure for invoking economic impact.

    Science.gov (United States)

    2010-07-01

    ... accordance with 33 CFR 209.120 and 209.145. (b) If the decision of the Chief of Engineers is that ocean... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Procedure for invoking economic impact... DUMPING CORPS OF ENGINEERS DREDGED MATERIAL PERMITS § 225.3 Procedure for invoking economic impact....

  9. 12 CFR 225.24 - Procedures for other nonbanking proposals.

    Science.gov (United States)

    2010-01-01

    ... notice for the Board's prior approval under § 225.21(a) to engage in or acquire a company engaged in a... of Procedure (12 CFR 262.3). (1) Engaging de novo in listed activities. A bank holding company... and the identity of the company that will conduct the activity. (2) Acquiring company engaged...

  10. Improved limit on the $^{225}$Ra electric dipole moment

    CERN Document Server

    Bishof, Michael; Bailey, Kevin G; Greene, John P; Holt, Roy J; Kalita, Mukut R; Korsch, Wolfgang; Lemke, Nathan D; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P; Singh, Jaideep T; Dietrich, Matthew R

    2016-01-01

    Background: Octupole-deformed nuclei, such as that of $^{225}$Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015, we reported the first "proof-of-principle" measurement of the $^{225}$Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our $^{225}$Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Method: Laser-cooled and trapped $^{225}$Ra atoms are held between two high voltage electrodes in an ultra high vacuum chamber at the center of a magnetically shielded environment. We observe Larmor precession in a uniform magnetic field using nuclear-spin-dependent laser light scattering and look for a phase shift proportional to the applied electric field, which indicates the existence of an EDM. The main improvement to o...

  11. 24 CFR 964.225 - Resident management requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Resident management requirements... Program § 964.225 Resident management requirements. The following requirements apply when a HA and its... contracting with a HA must establish a resident management corporation that meets the requirements for such...

  12. 12 CFR 225.28 - List of permissible nonbanking activities.

    Science.gov (United States)

    2010-01-01

    ... selling checks and related documents, including corporate image checks, cash tickets, voucher checks... itself. See also the Board's interpretation of bank management consulting advice (12 CFR 225.131). (1) On... management official, as defined in 12 CFR 212.2(h), of the company or any of its affiliates to serve as...

  13. Improved limit on the 225Ra electric dipole moment

    Science.gov (United States)

    Bishof, Michael; Parker, Richard H.; Bailey, Kevin G.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Singh, Jaideep T.; Dietrich, Matthew R.

    2016-08-01

    Background: Octupole-deformed nuclei, such as that of 225Ra, are expected to amplify observable atomic electric dipole moments (EDMs) that arise from time-reversal and parity-violating interactions in the nuclear medium. In 2015 we reported the first "proof-of-principle" measurement of the 225Ra atomic EDM. Purpose: This work reports on the first of several experimental upgrades to improve the statistical sensitivity of our 225Ra EDM measurements by orders of magnitude and evaluates systematic effects that contribute to current and future levels of experimental sensitivity. Method: Laser-cooled and trapped 225Ra atoms are held between two high-voltage electrodes in an ultrahigh-vacuum chamber at the center of a magnetically-shielded environment. We observe Larmor precession in a uniform magnetic field using nuclear-spin-dependent laser light scattering and look for a phase shift proportional to the applied electric field, which indicates the existence of an EDM. The main improvement to our measurement technique is an order-of-magnitude increase in spin-precession time, which is enabled by an improved vacuum system and a reduction in trap-induced heating. Results: We have measured the 225Ra atomic EDM to be less than 1.4 ×10-23e cm (95 % confidence upper limit), which is a factor of 36 improvement over our previous result. Conclusions: Our evaluation of systematic effects shows that this measurement is completely limited by statistical uncertainty. Combining this measurement technique with planned experimental upgrades, we project a statistical sensitivity at the 1 ×10-28e cm level and a total systematic uncertainty at the 4 ×10-29e cm level.

  14. 48 CFR 225.7009 - Restriction on ball and roller bearings.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on ball and roller bearings. 225.7009 Section 225.7009 Federal Acquisition Regulations System DEFENSE ACQUISITION... roller bearings....

  15. 48 CFR 225.7003 - Restrictions on acquisition of specialty metals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions on acquisition of specialty metals. 225.7003 Section 225.7003 Federal Acquisition Regulations System DEFENSE... Restrictions on acquisition of specialty metals....

  16. 27 CFR 25.225 - Destruction of taxpaid beer which was never removed from brewery premises.

    Science.gov (United States)

    2010-04-01

    ... beer which was never removed from brewery premises. 25.225 Section 25.225 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Voluntary Destruction § 25.225 Destruction of taxpaid beer which was never removed from brewery premises. (a) General....

  17. 48 CFR 225.871 - North Atlantic Treaty Organization (NATO) cooperative projects.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false North Atlantic Treaty Organization (NATO) cooperative projects. 225.871 Section 225.871 Federal Acquisition Regulations System... Other International Agreements and Coordination 225.871 North Atlantic Treaty Organization...

  18. 48 CFR 252.225-7016 - Restriction on acquisition of ball and roller bearings.

    Science.gov (United States)

    2010-10-01

    ... of ball and roller bearings. 252.225-7016 Section 252.225-7016 Federal Acquisition Regulations System... and roller bearings. As prescribed in 225.7009-5, use the following clause: Restriction on Acquisition of Ball and Roller Bearings (MAR 2006) (a) Definitions. As used in this clause' (1)...

  19. 40 CFR 795.225 - Dermal pharmacokinetics of DGBE and DGBA.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Dermal pharmacokinetics of DGBE and DGBA. 795.225 Section 795.225 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Guidelines § 795.225 Dermal pharmacokinetics of DGBE and DGBA. (a) Purpose. The purpose of these studies...

  20. Nuclear Structure Effects in the Exotic Decay of $^{225}$Ac via $^{14}$C Emission

    CERN Multimedia

    2002-01-01

    % IS323 \\\\ \\\\ We propose to build at Isolde a high intensity $^{225}$Ac source by $\\beta$-decay of $^{225}$(Ra+Fr) beam, to be used at the superconducting spectrometer SOLENO of IPN-Orsay in order to study a possible fine structure in the spectrum of $^{14}$C ions spontaneously emitted by $^{225}$Ac.

  1. 25 CFR 225.4 - Authority and responsibility of the Bureau of Land Management (BLM).

    Science.gov (United States)

    2010-04-01

    ... Agreements: Unproven Areas, 43 CFR part 3260—Geothermal Resources Operations, 43 CFR part 3280—Geothermal... Management (BLM). 225.4 Section 225.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS AGREEMENTS General § 225.4 Authority...

  2. 22 CFR 225.123 - Early termination of research support: Evaluation of applications and proposals.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Early termination of research support: Evaluation of applications and proposals. 225.123 Section 225.123 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.123 Early termination of research support: Evaluation...

  3. 48 CFR 225.873 - Waiver of United Kingdom commercial exploitation levies.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom commercial exploitation levies. 225.873 Section 225.873 Federal Acquisition Regulations System DEFENSE... International Agreements and Coordination 225.873 Waiver of United Kingdom commercial exploitation levies....

  4. 41 CFR 102-36.225 - Must we report excess related personal property?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Must we report excess related personal property? 102-36.225 Section 102-36.225 Public Contracts and Property Management Federal... Property § 102-36.225 Must we report excess related personal property? Yes, you must report excess...

  5. 48 CFR 52.225-14 - Inconsistency between English Version and Translation of Contract.

    Science.gov (United States)

    2010-10-01

    ... English Version and Translation of Contract. 52.225-14 Section 52.225-14 Federal Acquisition Regulations... CLAUSES Text of Provisions and Clauses 52.225-14 Inconsistency between English Version and Translation of Contract. As prescribed in 25.1103(b), insert the following clause: Inconsistency Between English...

  6. 12 CFR 225.174 - What aggregate thresholds apply to merchant banking investments?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What aggregate thresholds apply to merchant banking investments? 225.174 Section 225.174 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF...) Regulations Merchant Banking Investments § 225.174 What aggregate thresholds apply to merchant...

  7. 12 CFR 225.126 - Activities not closely related to banking.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Activities not closely related to banking. 225.126 Section 225.126 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE... Financial Holding Companies Interpretations § 225.126 Activities not closely related to banking. Pursuant...

  8. 12 CFR 225.172 - What are the holding periods permitted for merchant banking investments?

    Science.gov (United States)

    2010-01-01

    ... applicable under the Board's capital adequacy rules or guidelines (see 12 CFR 225 appendix A) to merchant... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What are the holding periods permitted for merchant banking investments? 225.172 Section 225.172 Banks and Banking FEDERAL RESERVE SYSTEM...

  9. 48 CFR 252.225-7030 - Restriction on Acquisition of Carbon, Alloy, and Armor Steel Plate.

    Science.gov (United States)

    2010-10-01

    ... of Carbon, Alloy, and Armor Steel Plate. 252.225-7030 Section 252.225-7030 Federal Acquisition... Acquisition of Carbon, Alloy, and Armor Steel Plate. As prescribed in 225.7011-3, use the following clause: Restriction on Acquisition of Carbon, Alloy, and Armor Steel Plate (DEC 2006) (a) Carbon, alloy, and...

  10. First Measurement of the Atomic Electric Dipole Moment of $^{225}$Ra

    CERN Document Server

    Parker, R H; Kalita, M R; Lemke, N D; Bailey, K G; Bishof, M N; Greene, J P; Holt, R J; Korsch, W; Lu, Z -T; Mueller, P; O'Connor, T P; Singh, J T

    2015-01-01

    The radioactive radium-225 ($^{225}$Ra) atom is a favorable case to search for a permanent electric dipole moment (EDM). Due to its strong nuclear octupole deformation and large atomic mass, $^{225}$Ra is particularly sensitive to interactions in the nuclear medium that violate both time-reversal symmetry and parity. We have developed a cold-atom technique to study the spin precession of $^{225}$Ra atoms held in an optical dipole trap, and demonstrated the principle of this method by completing the first measurement of its atomic EDM, reaching an upper limit of $|$$d$($^{225}$Ra)$|$ $<$ $5.0\\!\\times\\!10^{-22}$ $e \\cdot$cm (95$\\%$ confidence).

  11. Production of AC-225 and application of the BI-213 daughter in cancer therapy

    Science.gov (United States)

    Koch, L.; Apostolidis, C.; Janssens, W.; Molinet, R.; van Geel, J.

    1999-01-01

    There are several ongoing medical trials to use Bi-213 conjugated to monoclonal antibodies to kill tumour-cells of various cancer types. The institute is supplying Ac-225 generators for the test and is itself engaged in in-vitro cytotoxicity tests. Nuclear reactions leading to Ac-225 are discussed. The present supply of Ac-225 stems from Th-229 decay obtained from aged U-233. From the possible alternative the reactions Ra-226 (p, 2n) Ac-225 is presently favoured. The fabrication of a Ac-225 for Bi-213 generator will be described.

  12. 225 GHz Atmospheric Opacity Measurements from Two Arctic Sites

    CERN Document Server

    Matsushita, S; Martin-Cocher, P; Asada, K; Chen, C -P; Inoue, M; Paine, S; Turner, D; Steinbring, E

    2012-01-01

    We report the latest results of 225 GHz atmospheric opacity measurements from two arctic sites; one on high coastal terrain near the Eureka weather station, on Ellesmere Island, Canada, and the other at the Summit Station near the peak of the Greenland icecap. This is a campaign to search for a site to deploy a new telescope for submillimeter Very Long Baseline Interferometry and THz astronomy in the northern hemisphere. Since 2011, we have obtained 3 months of winter data near Eureka, and about one year of data at the Summit Station. The results indicate that these sites offer a highly transparent atmosphere for observations in submillimeter wavelengths. The Summit Station is particularly excellent, and its zenith opacity at 225 GHz is statistically similar to the Atacama Large Milllimeter/submillimeter Array in Chile. In winter, the opacity at the Summit Station is even comparable to that observed at the South Pole.

  13. An improved limit on the EDM of 225 Ra

    Science.gov (United States)

    Bishof, Michael; Bailey, Kevin; Dietrich, Matthew R.; Greene, John P.; Holt, Roy J.; Kalita, Mukut R.; Korsch, Wolfgang; Lemke, Nathan D.; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas P.; Parker, Richard H.; Rabga, Tenzin; Singh, Jaideep T.

    2016-05-01

    Searches for permanent electric dipole moments (EDMs) are sensitive probes of symmetry violation that could explain the dominance of matter over anti-matter. The 225 Ra (t1/2 = 15 days, I = 1/2) atom is a particularly attractive system to use for an EDM measurement because its octupole-deformed nucleus, closely spaced ground-state parity doublet, and large nuclear charge make 225 Ra uniquely sensitive to symmetry-violating interactions in the nuclear medium. In 2015, we reported the first ``proof of principle'' measurement of the 225 Ra EDM, giving a 95% confidence upper limit of 5* 10-22 e-cm; representing the first EDM measurement using laser-trapped atoms as well as the first EDM measurement of an atom with an octupole-deformed nucleus. After implementing upgrades to our apparatus, we now observe nuclear spin coherence after 20 s of free evolution - a factor of ten improvement. A new EDM measurement based on the upgraded system improved the 95% confidence upper limit by a factor of 36. We also report on the progress of current experimental upgrades that have the potential to further improve our EDM sensitivity by many orders of magnitude, allowing us to test symmetry violation at an unprecedented level. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  14. Search for a Permanent Electric Dipole Moment of 225Ra

    Science.gov (United States)

    Kalita, Mukut Ranjan

    The observation of a permanent electric dipole moment (EDM) in a non-degenerate system would indicate the violation of discrete symmetries of Time reversal (T) or combined application of Charge (C) and Parity (P) symmetry violation through the CPT theorem. The diamagnetic 225Ra atom with nuclear spin I=1/2 is a favorable candidate for an EDM search. Experimental sensitivity to its EDM is enhanced due to its high atomic mass and the increased Schiff moment of its octupole deformed nucleus. An experimental setup is developed where laser cooled neutral radium atoms are collected in a magneto-optical trap (MOT). The collected atoms are transported 1 meter with a far off-resonant optical dipole trap (ODT) and then the atoms are transferred to a second standing-wave ODT in an experimental chamber. The atoms are then optically polarized and allowed to Larmor precess in parallel and antiparallel electric and magnetic fields. The difference between the Larmor precession frequency for parallel and antiparallel fields is experimentally determined to measure the EDM. This thesis is about the first measurement of the EDM of the 225Ra atom where an upper limit of |d(225Ra)| EDM, CP violation, laser cooling and trapping, rare isotopes, radium.

  15. Effect of niobium on the embrittlement of 2.25 Cr and 2.25 Cr-1Mo steels by phosphous

    International Nuclear Information System (INIS)

    The influence of niobium on the temper embrittlement of 2.25Cr and 2.25 Cr-1Mo steels doped with phosphorus is evaluated. The transition temperatures of the samples tempered at 6500C and aged at different temperatures for niobium steels. (M.J.C.)

  16. Combined effects of C225 and 125-iodine seed radiation on colorectal cancer cells

    International Nuclear Information System (INIS)

    To characterize the effect of combined treatment of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 and 125-iodine (125I) seed radiation in human colorectal cancer. We treated LS180 cells with 125I continuous low dose rate radiation in the presence and absence of 100 nM C225. The clonogenic capacity, cellular proliferation, cell cycle distribution, apoptosis, and molecular pathways of the cells following the treatments were analyzed in vitro. The sensitizer enhancement ratio of C225 was approximately 1.4. Treatment with C225 and radiation alone produced significant inhibition of cell growth, but combination therapy produced greater inhibition than either treatment administered alone. C225 increased the radiation-induced apoptosis and the fraction of γ-H2AX foci positive cells at 48 h after treatment. The Akt phosphorylation level was lower in the cells receiving the combination treatment than in the cells treated with radiation or C225 alone. These findings indicate that C225 sensitizes LS180 cells to 125I seed radiation. Growth inhibition is mediated by inducing apoptosis and not cell cycle arrest. Additionally, we confirmed that C225 impairs DNA repair by reducing the cellular level of the DNA-PKcs and Ku70 proteins. Furthermore, the inhibition of Akt signaling activation may be responsible for the C225-mediated radiosensitization

  17. FORECASTING NIKKEI 225 INDEX WITH SUPPORT VECTOR MACHINE

    Institute of Scientific and Technical Information of China (English)

    HUANG Wei; Yoshiteru Nakamori; WANG Shouyang; YU Lean

    2003-01-01

    Support Vector Machine (SVM) is a very specific type of learning algorithms characterized by the capacity control of the decision function, the use of the kernel functions and the sparsity of the solution. In this paper, we investigate the predictability of financial movement direction with SVM by forecasting the weekly movement direction of NIKKEI 225 index. To evaluate the forecasting ability of SVM, we compare the performance with those of Linear Discriminant Analysis, Quadratic Discriminant Analysis and Elman Backpropagation Neural Networks. The experiment results show that SVM outperforms other classification methods. Furthermore, we propose a combining model by integrating SVM with other classification methods. The combining model performs the best among the forecasting methods.

  18. 12 CFR 225.102 - Bank holding company indirectly owning nonbanking company through subsidiaries.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company indirectly owning nonbanking company through subsidiaries. 225.102 Section 225.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  19. 41 CFR 102-33.225 - How must we manage aircraft parts?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How must we manage aircraft parts? 102-33.225 Section 102-33.225 Public Contracts and Property Management Federal Property... must we manage aircraft parts? You must manage your aircraft parts by maintaining proper...

  20. 7 CFR Appendix C to Part 225 - Child Nutrition (CN) Labeling Program

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Child Nutrition (CN) Labeling Program C Appendix C to... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM Pt. 225, App. C Appendix C to Part 225—Child Nutrition (CN) Labeling Program 1. The Child Nutrition (CN) Labeling...

  1. 2 CFR Appendix E to Part 225 - State and Local Indirect Cost Rate Proposals

    Science.gov (United States)

    2010-01-01

    ... 2 CFR 225 and maintain the proposal and related supporting documentation for audit. These... should be held within practical limits, taking into consideration the materiality of the amounts involved... 2 CFR part 225 adopts the concept of the full allocation of indirect costs, there are some...

  2. 76 FR 54527 - Fourth Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    Science.gov (United States)

    2011-09-01

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  3. 76 FR 38741 - Third Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    Science.gov (United States)

    2011-07-01

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  4. 76 FR 6180 - First Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    Science.gov (United States)

    2011-02-03

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  5. 76 FR 22161 - Second Meeting: RTCA Special Committee 225: Rechargeable Lithium Batteries and Battery Systems...

    Science.gov (United States)

    2011-04-20

    ... and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 225 meeting: Rechargeable Lithium Batteries and Battery Systems--Small... Special Committee 225: Rechargeable Lithium Batteries and Battery Systems--Small and Medium Sizes....

  6. 12 CFR 225.140 - Disposition of property acquired in satisfaction of debts previously contracted.

    Science.gov (United States)

    2010-01-01

    ... satisfaction of debts previously contracted. 225.140 Section 225.140 Banks and Banking FEDERAL RESERVE SYSTEM... property acquired in satisfaction of debts previously contracted. (a) The Board recently considered the... acquiring and holding assets acquired in satisfaction of a debt previously contracted in good faith (a...

  7. 20 CFR 225.33 - Months for which DRC's are due.

    Science.gov (United States)

    2010-04-01

    ... Section 225.33 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT PRIMARY INSURANCE AMOUNT DETERMINATIONS Delayed Retirement Credits § 225.33 Months for which DRC's are due. (a) A DRC is due for each month after 1970 in which the employee is— (1) Full retirement age or...

  8. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a), use the following clause: Balance of Payments...

  9. 48 CFR 252.225-7032 - Waiver of United Kingdom Levies-Evaluation of offers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7032 Waiver of United Kingdom Levies—Evaluation of offers. As prescribed in 225.1101(8), use the following provision: Waiver of United...

  10. 48 CFR 252.225-7033 - Waiver of United Kingdom levies.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Waiver of United Kingdom... of Provisions And Clauses 252.225-7033 Waiver of United Kingdom levies. As prescribed in 225.1101(9), use the following clause: Waiver of United Kingdom Levies (APR 2003) (a) The U.S. Government...

  11. 48 CFR 225.7011 - Restriction on carbon, alloy, and armor steel plate.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on carbon, alloy, and armor steel plate. 225.7011 Section 225.7011 Federal Acquisition Regulations System DEFENSE... on carbon, alloy, and armor steel plate....

  12. 9 CFR 381.225 - Criteria and procedure for designating establishments with operations which would clearly...

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Criteria and procedure for designating establishments with operations which would clearly endanger the public health; disposition of poultry products therein. 381.225 Section 381.225 Animals and Animal Products FOOD SAFETY AND INSPECTION...

  13. 24 CFR 3.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Educational institutions eligible to submit transition plans. 3.225 Section 3.225 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS...

  14. 48 CFR 225.403 - World Trade Organization Government Procurement Agreement and Free Trade Agreements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false World Trade Organization Government Procurement Agreement and Free Trade Agreements. 225.403 Section 225.403 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Trade...

  15. 12 CFR Appendix G to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Internal-Ratings-Based and Advanced...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Capital Adequacy Guidelines for Bank Holding... COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Pt. 225, App. G Appendix G to Part 225—Capital Adequacy... company that uses 12 CFR part 225, appendix G, to calculate its risk-based capital requirements. (2)...

  16. 12 CFR 225.130 - Issuance and sale of short-term debt obligations by bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Issuance and sale of short-term debt obligations by bank holding companies. 225.130 Section 225.130 Banks and Banking FEDERAL RESERVE SYSTEM... CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.130 Issuance and...

  17. Importance of maintenance therapy in C225-induced enhancement of tumor control by fractionated radiation

    International Nuclear Information System (INIS)

    Purpose: C225 strongly enhances tumor radioresponse when given concurrently with radiotherapy. We investigated whether additional therapeutic benefit could be achieved by continuing maintenance treatment with C225 after the completion of fractionated radiotherapy. Methods and Materials: A431 xenografts were treated with local irradiation or combined with C225 by two different schedules: (1) 6 h before the first dose of irradiation and at 3-day intervals for a total of 3 doses during the 7-day fractionated radiotherapy, or (2) 6 doses of C225 given both during radiotherapy and continuing for 3 additional doses after radiotherapy. Tumor cure was assessed by the radiation dose yielding local tumor control in 50% of animals (TCD50), and time to recurrence was also determined. Results: Both treatment schedules increased radiocurability as evidenced by reductions in TCD50, but the effect was greater when C225 was given both during and after radiotherapy. C225 reduced the TCD50 of 83.1 (73.2-124.8) Gy by radiation only to 46.2 (39.1-57.5) Gy when given during radiotherapy and to 30.8 (22.2-38.0) Gy when given during and after radiotherapy. Dose modification factors were 1.8 when C225 was given during radiotherapy and 2.7 when given both during and after radiotherapy. C225 was also effective in delaying the onset of tumor recurrences, and was more effective when given as both concurrent and maintenance therapy. Conclusions: Data showed that C225 strongly enhanced the curative effect of fractionated radiation, and its effect was greater if administration was extended beyond the end of radiotherapy. This important finding may influence future designs of clinical trials combining anti-EGFR (anti-epidermal growth factor receptor) agents with radiotherapy

  18. Nuclear structure effects in the exotic decay of $^{225}$Ac via $^{14}$C emission

    CERN Document Server

    Bonetti, R; Guglielmetti, A; Matheoud, R; Migliorino, C; Pasinetti, A L; Ravn, H L

    1993-01-01

    By using a $^{225}$Ac source produced at the electromagnetic separator Isolde we collected on our track-recording glass detectors 305 $^{14}$C events from the radioactive decays of $^{225}$Ac and its daughter $^{221}$Fr and obtained, for $^{225}$Ac, a branching ratio B($^{14}$C/$\\alpha$)=(6.0 $\\pm$ 1.3) x 10$^{-12}$. Our result suggests that such a decay from an odd proton nucleus is dominated by transition to the ground or to the first excited state of daughter nucleus.

  19. Results of the Test Program for Replacement of AK-225G Solvent for Cleaning NASA Propulsion Oxygen Systems

    Science.gov (United States)

    Lowrey, Nikki M.; Mitchell, Mark A.

    2016-01-01

    Since the 1990's, when the Class I Ozone Depleting Substance chlorofluorocarbon-113 was banned, NASA's propulsion test facilities at Marshall Space Flight Center and Stennis Space Center have relied upon the solvent Asahiklin AK-225 (hydrochlorofluorocarbon-225ca/cb or HCFC-225ca/cb) and, more recently AK-225G (the single isomer form, HCFC-225cb) to safely clean and verify the cleanliness of large scale propulsion oxygen systems. Effective January 1, 2015, the production, import, export, and new use of Class II Ozone Depleting Substances, including AK-225G, was prohibited in the United States by the Clean Air Act. In 2012 through 2014, NASA test labs at MSFC, SSC, and Johnson Space Center's White Sands Test Facility collaborated to seek out, test, and qualify a solvent replacement for AK-225G that is both an effective cleaner and safe for use with oxygen systems. This paper summarizes the tests performed, results, and lessons learned.

  20. A two-dimensional phase separation on the spherical surface of the metallic glass Au55Pb22.5Sb22.5

    Science.gov (United States)

    Lee, M. C.; Johnson, W. L.

    1982-01-01

    Recent experiments indicate that a phase separation in a spherical sample of the metallic glass Au55Pb22.5Sb22.5 occurs near the surface of the sphere. This strongly suggests either a contribution of surface-free energy to the decomposition process or a possible influence of near surface impurities absorbed during synthesis of the sphere. The surface phase separation has been studied as a function of cooling rate of the sphere. At high cooling rates (small sphere sizes), the surface separation disappears altogether suggesting that the surface of the parent liquid droplet is initially homogeneous.

  1. Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles

    International Nuclear Information System (INIS)

    Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of 221Fr and 213Bi when encapsulating 225Ac. - Highlights: • First reported loading of 213Bi and 225Ac in polymer vesicles (i.e. polymersomes). • Encapsulating 225Ac in polymersomes results in up to 69 % recoil retention of 221Fr. • Encapsulating 225Ac in polymersomes results in up to 53 % recoil retention of 213Bi

  2. 25 CFR 225.29 - Corporate qualifications and requests for information.

    Science.gov (United States)

    2010-04-01

    ... OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS AGREEMENTS Minerals Agreements § 225.29 Corporate..., constitutes certification that the individual signing (except a surety agent) is authorized to act in such...

  3. Laser trapping of Ra-225 and Ra-226 and progress towards an electric dipole moment measurement

    Science.gov (United States)

    Guest, J. R.; Scielzo, N. D.; Ahmad, I.; Bailey, K.; Greene, J. P.; Holt, R. J.; Lu, Z.-T.; O'Connor, T. P.; Potterveld, D. H.

    2006-10-01

    Permanent electric dipole moments (EDMs) in atoms or molecules are signatures of Time (T)-and Parity (P)-violation and represent an important window onto physics beyond the Standard Model. We are developing a next generation EDM search around laser-cooled and trapped Ra-225 (t1/2 = 15 d). Due to octupole deformation of the nucleus, Ra-225 is predicted to be two to three orders of magnitude more sensitive to T-violating interactions than Hg-199, which currently sets the most stringent limits in the nuclear sector. We will discuss our progress, including the successful laser cooling and trapping of Ra-225 and Ra-226 atoms. We have demonstrated transverse cooling, Zeeman slowing, and capture of Ra-225 and Ra-226 atoms in a magneto-optical trap (MOT). By driving a second atomic transition, we have extended the lifetime of the trap from milliseconds to seconds and performed necessary spectroscopic measurements.

  4. Production of Ac-225 for cancer therapy by photon-induced transmutation of Ra-226.

    Science.gov (United States)

    Melville, G; Meriarty, H; Metcalfe, P; Knittel, T; Allen, B J

    2007-09-01

    The increasing application of Ac-225 for cancer therapy indicates the potential need for its increased production and availability. The production of Ac-225 has been achieved using bremsstrahlung photons from an 18 MV medical linear accelerator (linac) to bombard a Ra-226 target. A linac dose of 2800 Gy produced about 64 microCi of Ra-225, which decays to Ac-225. This result, while consistent with the theoretical calculations, is far too low to be of practical use. A more powerful linac is required that runs at a higher current, longer pulse length and higher frequency for practical production. This process could also lead to the reduction of the nuclear waste product Ra-226.

  5. Search for Electric dipole moment (EDM) in laser cooled and trapped 225Ra atoms

    Science.gov (United States)

    Kalita, Mukut; Bailey, Kevin; Dietrich, Matthew; Green, John; Holt, Roy; Korsch, Wolfgang; Lu, Zheng-Tian; Lemke, Nathan; Mueller, Peter; O'Connor, Tom; Parker, Richard; Singh, Jaideep; Trimble, Will; Argonne National Laboratory Collaboration; University Of Chicago Collabration; University Of Kentucky Collaboration

    2014-05-01

    We are searching for an EDM of the diamagnetic 225Ra atom. 225Ra has nuclear spin I =1/2. Experimental sensitivity to its EDM is enhanced due to its heavy mass and the increased Schiff moment of its octupole deformed nucleus. Our experiment involves collecting laser cooled Ra atoms in a magneto-optical trap (MOT), transporting them 1 meter with a far off-resonant optical dipole trap (ODT) and then transferring the atoms to a second standing-wave ODT in our experimental chamber. We will report our recent experiences in polarizing and observing Larmor precession of 225Ra atoms in parallel electric and magnetic fields in a magnetically shielded region and progress towards a first measurement of the EDM of 225Ra. This work is supported by DOE, Office of Nuclear Physics, under contract No. DE-AC02-06CH11357 and contract No. DE-FG02-99ER41101.

  6. 47 CFR 95.225 - (R/C Rule 25) How do I contact the FCC?

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false (R/C Rule 25) How do I contact the FCC? 95.225... (R/C Rule 25) How do I contact the FCC? (a) FCC National Call Center at 1-888-225-5322. (b) FCC World Wide Web homepage: http://www.fcc.gov. (c) In writing, to FCC, Attention: R/C, 1270 Fairfield...

  7. Auricular reconstruction of congenital microtia: personal experience in 225 cases.

    Science.gov (United States)

    Anghinoni, M; Bailleul, C; Magri, A S

    2015-06-01

    Microtia is a congenital disease with various degrees of severity, ranging from the presence of rudimentary and malformed vestigial structures to the total absence of the ear (anotia). The complex anatomy of the external ear and the necessity to provide good projection and symmetry make this reconstruction particularly difficult. The aim of this work is to report our surgical technique of microtic ear correction and to analyse the short and long term results. From 2000 to 2013, 210 patients affected by microtia were treated at the Maxillo-Facial Surgery Division, Head and Neck Department, University Hospital of Parma. The patient population consisted of 95 women and 115 men, aged from 7 to 49 years. A total of 225 reconstructions have been performed in two surgical stages basing of Firmin's technique with some modifications and refinements. The first stage consists in fabrication and grafting of a three-dimensional costal cartilage framework. The second stage is performed 5-6 months later: the reconstructed ear is raised up and an additional cartilaginous graft is used to increase its projection. A mastoid fascial flap together with a skin graft are then used to protect the cartilage graft. All reconstructions were performed without any major complication. The results have been considered satisfactory by all patients starting from the first surgical step. Low morbidity, the good results obtained and a high rate of patient satisfaction make our protocol an optimal choice for treatment of microtia. The surgeon's experience and postoperative patient care must be considered as essential aspects of treatment. PMID:26246664

  8. 女性生殖管道发育异常225例临床分析%Clinical analysis of 225 women with congenital uterine malformation

    Institute of Scientific and Technical Information of China (English)

    王世军; Mandakini Oli; 蒋励; 王建六; 魏丽惠

    2008-01-01

    目的 探讨子宫发育异常的发病情况、临床特征、诊治方法及其对生育的影响.方法 选取1990年3月-2005年1月北京大学人民医院收治的子宫发育异常患者225例的临床资料,进行回顾性分析,总结不同类型子宫发育异常的构成比、临床特征、诊治方法及对生育的影响.结果 (1)225例子宫发育异常患者中,中隔子宫125例,占55.6%,其中122例(97.6%,122/125)患者妊娠,但影响其妊娠结局,出现流产、胎位异常、早产、前置胎盘、胎膜早破等并发症.(2)双子宫51例,占22.7%(51/225);其中50例(98%,50/51)患者妊娠,对妊娠无明显影响;5例(10%,5/51)合并泌尿系统畸形.(3)残角子宫26例(11.6%,26/225),发生残角子宫妊娠4例(15%,4/26),残角子宫同侧输卵管妊娠1例(4%,1/26);2例(8%,2/26)合并泌尿系统畸形;合并不孕4例(15%,4/26).(4)双角子宫14例,占6.2%(14/225),无不孕患者,出现早产、胎膜早破等并发症;1例(7%,1/14)合并泌尿系统畸形.(5)其他类型:鞍状子宫4例(1.8%,4/225),无不孕患者;无子宫3例(1.3%,3/225),均以原发闭经就诊;单角子宫2例(0.9%,2/225),均合并不孕.结论 子宫发育异常中以中隔子宫最多见.中隔子宫、双子宫、双角子官、残角子宫、鞍状子宫对生育无明显影响,但在妊娠期可出现不同的并发症.子宫发育异常常合并泌尿系统畸形.无症状的子宫发育异常,可不予处理.%Objective To investigate the prevalence, clinical features, diagnosis, treatment and the influence on procreation of uterine malformation. Methods Totally 225 women with uterine malformation referred to our hospital from Mar 1990 to Jan 2005 were involved in this retrospective analysis.The constituent ratio, clinical feature, diagnosis, treatment and the influence on procreation were analyzed.Results (1) Among 225 cases of uterine malformation, 125 cases (55.6%) were septate uterus; 122(97.6%, 122/125 ) of these patients became pregnant, but

  9. Composite outcomes in 2.25-mm drug eluting stents: a systematic review

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Justin Z. [Department of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ, 85724 (United States); Singh, Nirmal [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Ortega, Gilbert [College of Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Low, See Wei; Kanakadandi, Uday [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Fortuin, F. David [Department of Cardiovascular Diseases, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ, 85054 (United States); Lassar, Tom [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States); Lee, Kwan S., E-mail: klee@shc.arizona.edu [Department of Cardiovascular Diseases, University of Arizona, 1501 N Campbell Ave, Tucson, AZ, 85724 (United States)

    2015-06-15

    Background: Coronary atherosclerosis often involves small-caliber coronaries, yet the safety and efficacy of 2.25-mm DES have been poorly defined, with a general lack of separation of 2.25 with 2.5-mm performance. No randomized head-to-head 2.25 mm DES studies have been reported. There are several single-arm prospective studies, and we aim to systematically review all published specific 2.25-mm data to estimate composite DES-specific performance and highlight current knowledge gaps. Methods: We performed a systematic literature search of PubMed, EMBASE, Web of Science and Cochrane database for clinical trials of 2.25-mm DES. Angiographic and composite clinical outcomes were compared with descriptive statistics. Results: 2.25 mm-Paclitaxel (PES), sirolimus (SES), everolimus (EES) and platinum chromium EES DES-specific outcomes have been reported. Death at 12 months for SES, PES, EES and platinum chromium EES was 1.3%, 3.0%, 1.5%, and 4.4%. Rates of target vessel revascularization at 12 months for SES, PES, EES and platinum chromium EES were 5.7%, 13.3%, 8.8%, and 3.3%. Angiographic outcomes at 9 months to one year were as follows: mean late lumen loss (LLL) for SES, PES, and EES was 0.15 ± 0.11-mm, 0.28 ± 0.11-mm, and 0.16 ± 0.41-mm and mean diameter restenosis for SES, PES, and EES were 29.5 ± 6.2%, 34.7 ± 4.2%, and 20.9 ± 22.5%. Reported stent thrombosis rates for 2.25-mm DES were low ranging from 0% to 2.2% in up to 24-months of follow-up. Conclusions: This systematic review summarizes and tabulates all available specific data on 2.25-mm DES. Based on our descriptive analysis, 2.25-mm DESs have a favorable safety and efficacy profile for the treatment of very small coronary lesions. - Highlights: • Safety and efficacy of 2.25-mm DES have been poorly defined. • We performed a systematic review on all published 2.25 mm data to estimate composite DES-specific performance and highlight current knowledge gaps. • We pooled data from 9 clinical studies and 1

  10. 12 CFR 225.171 - What are the limitations on managing or operating a portfolio company held as a merchant banking...

    Science.gov (United States)

    2010-01-01

    ... restrictions on such activities contained in §§ 225.28(b)(6) or 225.86(b)(1) of this part (12 CFR 225.28(b)(6... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What are the limitations on managing or operating a portfolio company held as a merchant banking investment? 225.171 Section 225.171 Banks...

  11. 12 CFR 225.104 - “Services” under section 4(c)(1) of Bank Holding Company Act.

    Science.gov (United States)

    2010-01-01

    ... company chooses to have done through another organization. Moreover, the report of the Senate Banking and... Holding Company Act. 225.104 Section 225.104 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF... Holding Company Act. (a) Section 4(c)(1) of the Bank Holding Company Act, among other things, exempts...

  12. 48 CFR 225.770 - Prohibition on acquisition of United States Munitions List items from Communist Chinese military...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Prohibition on acquisition of United States Munitions List items from Communist Chinese military companies. 225.770 Section 225... of United States Munitions List items from Communist Chinese military companies. This...

  13. 48 CFR 252.225-7007 - Prohibition on Acquisition of United States Munitions List Items from Communist Chinese Military...

    Science.gov (United States)

    2010-10-01

    ... Regulation in 22 CFR Part 121. (b) Any supplies or services covered by the United States Munitions List that... of United States Munitions List Items from Communist Chinese Military Companies. 252.225-7007 Section... Chinese Military Companies. As prescribed in 225.1103(4), use the following clause: Prohibition...

  14. 12 CFR Appendix D to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Tier 1 Leverage Measure

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Capital Adequacy Guidelines for Bank Holding... CONTROL (REGULATION Y) Pt. 225, App. D Appendix D to Part 225—Capital Adequacy Guidelines for Bank Holding... of capital adequacy. This is consistent with the Federal Reserve's risk-based capital guidelines...

  15. 12 CFR Appendix A to Part 225 - Capital Adequacy Guidelines for Bank Holding Companies: Risk-Based Measure

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Capital Adequacy Guidelines for Bank Holding... (REGULATION Y) Pt. 225, App. A Appendix A to Part 225—Capital Adequacy Guidelines for Bank Holding Companies...-based capital measure to assist in the assessment of the capital adequacy of bank holding...

  16. 12 CFR 225.82 - How does a bank holding company elect to become a financial holding company?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false How does a bank holding company elect to become a financial holding company? 225.82 Section 225.82 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  17. 21 CFR 2.25 - Grain seed treated with poisonous substances; color identification to prevent adulteration of...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Grain seed treated with poisonous substances; color identification to prevent adulteration of human and animal food. 2.25 Section 2.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ADMINISTRATIVE RULINGS AND DECISIONS Human and Animal Foods...

  18. 22 CFR 225.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Science.gov (United States)

    2010-04-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 225.120 Section 225... Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. The department or agency head will evaluate all applications and...

  19. 12 CFR 225.145 - Limitations established by the Competitive Equality Banking Act of 1987 on the activities and...

    Science.gov (United States)

    2010-01-01

    ... mortgage lending. Additionally, the Board's decisions under section 4 of the Act have recognized mortgage..., credit card and mortgage lending. 12 CFR 225.25(b)(1). Finally, CEBA itself recognizes the specialized... provisions of the Board's Regulation Y (12 CFR 225.52). 1 12 U.S.C. 1843(f). Such a company is treated as...

  20. 21 CFR 172.225 - Methyl and ethyl esters of fatty acids produced from edible fats and oils.

    Science.gov (United States)

    2010-04-01

    ... from edible fats and oils. 172.225 Section 172.225 Food and Drugs FOOD AND DRUG ADMINISTRATION... Methyl and ethyl esters of fatty acids produced from edible fats and oils. Methyl esters and ethyl esters of fatty acids produced from edible fats and oils may be safely used in food, subject to...

  1. 48 CFR 225.7303-2 - Cost of doing business with a foreign government or an international organization.

    Science.gov (United States)

    2010-10-01

    ... reasonable and allocable costs of doing business with a foreign government or international organization... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Cost of doing business with a foreign government or an international organization. 225.7303-2 Section 225.7303-2...

  2. A theoretical model for the production of Ac-225 for cancer therapy by neutron capture transmutation of Ra-226.

    Science.gov (United States)

    Melville, G; Melville, P

    2013-02-01

    Radium needles that were once implanted into tumours as a cancer treatment are now obsolete and constitute a radioactive waste problem, as their half-life is 1600 years. We are investigating the reduction of radium by transmutation by bombarding Ra-226 with high-energy neutrons from a neutron source to produce Ra-225 and hence Ac-225, which can be used as a generator to produce Bi-213 for use in 'Targeted Alpha Therapy' for cancer. This paper examines the possibility of producing Ac-225 by neutron capture using a theoretical model in which neutron energy is convoluted with the corresponding neutron cross sections of Ra-226. The total integrated yield can then be obtained. This study shows that an intense beam of high-energy neutrons could initiate neutron capture on Ra-226 to produce Ra-225 and hence practical amounts of Ac-225 and a useful reduction of Ra-226.

  3. 20 CFR 225.24 - SS Earnings PIA used in survivor annuities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false SS Earnings PIA used in survivor annuities... Amount of the Residual Lump-Sum Payable § 225.24 SS Earnings PIA used in survivor annuities. The Social Security Earnings PIA (SS Earnings PIA) used in survivor annuities may be used in computing the tier...

  4. 78 FR 16031 - Twelfth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    Science.gov (United States)

    2013-03-13

    ... Federal Aviation Administration Twelfth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  5. 78 FR 6845 - Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    Science.gov (United States)

    2013-01-31

    ... Federal Aviation Administration Eleventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  6. 77 FR 39321 - Eighth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    Science.gov (United States)

    2012-07-02

    ... Federal Aviation Administration Eighth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Sizes AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Sizes. SUMMARY: The FAA is issuing this notice...

  7. 33 CFR 150.225 - What training and instruction are required?

    Science.gov (United States)

    2010-07-01

    ... hold. Procedures for documenting employee training must be outlined in the operations manual. ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What training and instruction are... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Personnel § 150.225 What training...

  8. First Measurement of the Permanent Electric Dipole Moment of Radium-225

    Science.gov (United States)

    Singh, Jaideep T.; Bailey, K. G.; Bishof, M. N.; Dietrich, M. R.; Greene, J. P.; Holt, R. J.; Kalita, M. R.; Korsch, W.; Lemke, N. D.; Lu, Z.-T.; Mueller, P.; O'Connor, T. P.; Parker, R. H.

    2015-04-01

    Electric dipole moments (EDMs) are signatures of time-reversal (T), parity (P),& charge-parity (CP) violation. CP -violation beyond the Standard Model is generally believed to be required to explain the observed prevalence of matter over antimatter in the universe. Radium-225 (τ1 / 2 = 14 . 7 d, I = 1 / 2) is mostly sensitive to T- and P-violating interactions originating within the nucleus. The best limits on these types of exotic interactions are derived from the atomic EDM limit for Mercury-199. Because of its unusual nuclear structure (octupole deformation), Ra-225 is expected to have a physics sensitivity that is a few hundred to a few thousand times higher than Hg-199. Laser cooling & trapping techniques are performed to collect & transport the cold Ra atoms into the measurement region. An EDM measurement is then performed by searching for a linear electric field dependent shift in the nuclear spin precession frequency of Ra-225. We will report on the first measurement of the atomic EDM of Ra-225 as well as plans for future improvements. This work is supported by U.S. DOE, Office of Science, Office of Nuclear Physics, under Contract DE-AC02-06CH11357.

  9. 22 CFR 225.118 - Applications and proposals lacking definite plans for involvement of human subjects.

    Science.gov (United States)

    2010-04-01

    ... INTERNATIONAL DEVELOPMENT PROTECTION OF HUMAN SUBJECTS § 225.118 Applications and proposals lacking definite plans for involvement of human subjects. Certain types of applications for grants, cooperative agreements, or contracts are submitted to departments or agencies with the knowledge that subjects may...

  10. 25 CFR 225.35 - Inspection of premises; books and accounts.

    Science.gov (United States)

    2010-04-01

    ... records pertaining to a minerals agreement shall be maintained by an operator in accordance with 30 CFR... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises; books and accounts. 225.35...; books and accounts. (a) Operators shall allow Indian mineral owners, their authorized...

  11. A=225 implantation for $^{221}$Fr source for TRIUMF atom trap

    CERN Multimedia

    The FrPNC Collaboration is mounting an atom trap for parity violation experiments and precision spectroscopy on francium atoms at TRIUMF's ISAC facility. We would like to use ISOLDE's capability of simultaneously implanting A=225 (while another experiment runs online) to make a long-lived source feeding $^{221}$Fr for tests of the trap. $^{225}$Ra $\\beta$-decays to $^{225}$Ac, which then $\\alpha$-decays, producing 100 keV $^{221}$Fr t$_{1/2}$= 4.8 minute recoils. The implanted A=225 source would be shipped to TRIUMF, where it would be held for several minutes at a time a few mm from the same yttrium foil that normally receives the ISAC beam. SRIM calculations imply that 20% of the $^{221}$Fr will be implanted in a 1 cm diameter spot on the yttrium. Then the yttrium foil is moved to the trap and heated to release the Fr atoms, just as in normal ISAC online operation. A test implantation will be done at 10$^{7}$/sec production for 1 day, testing whether carbon cracking on the implantation foil in the mass separ...

  12. 12 CFR 225.81 - What is a financial holding company?

    Science.gov (United States)

    2010-01-01

    ... RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies § 225.81 What is a financial holding company? (a) Definition. A financial holding... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What is a financial holding company?...

  13. 77 FR 8325 - Sixth Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

    Science.gov (United States)

    2012-02-14

    ... Batteries and Battery Systems, Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise the public of the sixth meeting of RTCA Special Committee 225, Rechargeable Lithium Batteries and...

  14. 77 FR 20688 - Seventh Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

    Science.gov (United States)

    2012-04-05

    ... Batteries and Battery Systems, Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Batteries and Battery Systems, Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise the public of the seventh meeting of RTCA Special Committee 225, Rechargeable Lithium Batteries and...

  15. 12 CFR 225.122 - Bank holding company ownership of mortgage companies.

    Science.gov (United States)

    2010-01-01

    ... “incidental powers” clause. (See 1966 Federal Reserve Bulletin 1151; 12 CFR 208.119.) Accordingly, a bank... the 1958 Federal Reserve Bulletin at page 431 (12 CFR 225.104), the legislative history of the... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company ownership of...

  16. CCD UBV Photometry and Kinematics of the Open Cluster NGC 225

    CERN Document Server

    Bilir, S; Yontan, T; Guver, T; Bakis, V; Ak, T; Ak, S; Paunzen, E; Eker, Z

    2016-01-01

    We present the results of CCD $UBV$ photometric and spectroscopic observations of the open cluster NGC 225. In order to determine the structural parameters of NGC 225, we calculated the stellar density profile in the cluster's field. We estimated the probabilities of the stars being physical members of the cluster using the existing astrometric data. The most likely members of the cluster were used in the determination of the astrophysical parameters of the cluster. We calculated the mean radial velocity of the cluster as $V_{r}=-8.3\\pm 5.0$ km s$^{-1}$ from the optical spectra of eight stars in the cluster's field. Using the U-B vs B-V two-colour diagram and UV excesses of the F-G type main-sequence stars, the reddening and metallicity of NGC 225 were inferred as $E(B-V)=0.151\\pm 0.047$ mag and $[Fe/H]=-0.11\\pm 0.01$ dex, respectively. We fitted the colour-magnitude diagrams of NGC 225 with the PARSEC isochrones and derived the distance modulus, distance and age of the cluster as $\\mu_{V}=9.3\\pm 0.07$ mag, d...

  17. 2 CFR Appendix A to Part 225 - General Principles for Determining Allowable Costs

    Science.gov (United States)

    2010-01-01

    ... Agreements with Institutions of Higher Education, Hospitals, and Other Non-Profit Organizations (Circular A... appendix and other appendices to 2 CFR part 225 as “Federal awards”). The principles are for the purpose of... or governmental unit participation in the financing of a particular program or project....

  18. 47 CFR 25.225 - Geographic Service Requirements for 17/24 GHz Broadcasting Satellite Service.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Geographic Service Requirements for 17/24 GHz... (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.225 Geographic Service Requirements for 17/24 GHz Broadcasting Satellite Service. (a) Each operator of a 17/24 GHz BSS space...

  19. 48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Balance of Payments... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7045 Balance of Payments... clause: Balance of Payments Program—Construction Material Under Trade Agreements (NOV 2009)...

  20. 20 CFR 405.225 - Notice of the Federal reviewing official's decision.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Notice of the Federal reviewing official's... PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Review of Initial Determinations by a Federal Reviewing Official § 405.225 Notice of the Federal reviewing official's decision. We will mail a written notice...

  1. 22 CFR 225.119 - Research undertaken without the intention of involving human subjects.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Research undertaken without the intention of... PROTECTION OF HUMAN SUBJECTS § 225.119 Research undertaken without the intention of involving human subjects. In the event research is undertaken without the intention of involving human subjects, but it...

  2. 12 CFR 225.127 - Investment in corporations or projects designed primarily to promote community welfare.

    Science.gov (United States)

    2010-01-01

    ... managerial resources making them particularly suited for a meaningful and substantial role in remedying our social ills. Section 225.25(b)(6) is intended to provide an opportunity for them to assume such a role...) to enable bank holding companies to take an active role in the quest for solutions to the...

  3. 2 CFR Appendix B to Part 225 - Selected Items of Cost

    Science.gov (United States)

    2010-01-01

    ... maintaining the image of the governmental unit or maintaining or promoting understanding and favorable... appendices under 2 CFR Part 225, and that the total compensation for individual employees: (1) Is reasonable..., accessories, or auxiliary apparatus necessary to make it usable for the purpose for which it is...

  4. 48 CFR 225.872-7 - Industrial security for qualifying countries.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial security for... Agreements and Coordination 225.872-7 Industrial security for qualifying countries. The required procedures... qualifying country sources are in the DoD Industrial Security Regulation DoD 5220.22-R (implemented for...

  5. The feasibility of [sup 225]Ac as a source of [alpha]-particles in radioimmunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Geerlings, M.W.; Hout, R. van der (Akzo nv, Arnhem (Netherlands)); Kaspersen, F.M. (Organon International bv, Oss (Netherlands)); Apostolides, C. (Commission of the European Communities, Karlsruhe (Germany). European Inst. for Transuranium Elements)

    1993-02-01

    This paper proposes the utilization of [sup 225]Ac for the [alpha]-radioimmunotherapy of cancer. The isotope decays with a radioactive half-life of 10 days into a cascade of short-lived [alpha]-and [beta]-emitting isotopes. In addition, when indicated by the pharmacokinetic requirements of particular clinical applications, [sup 213]Bi, with a radioactive half-life of 47 min, can be chosen as an alternative source of [alpha]-particles in radioimmunotherapy. This isotope is the last [alpha] emitter in the [sup 225]Ac decay-cascade and can be extracted from a [sup 225]Ac source at the bedside of the patient. [sup 225]Ac can quasi ad infinitum be obtained from one of its precursors, [sup 229]Th, which can be made available by various means. The indications for the use of [alpha]-particles as an alternative to more traditional classes of radiation are derived from the particle-kinetic characteristics and the radioactive half-life of their source isotope, as well as from the properties of the target-selective carrier moiety for the source isotope. It may be expected that useful applications, complementary to and/or in conjunction with other means of therapy will be identified. (author).

  6. 2 CFR Appendix C to Part 225 - State/Local-Wide Central Service Cost Allocation Plans

    Science.gov (United States)

    2010-01-01

    ... cost allocations or billings for are allowable in accordance with the requirements of 2 CFR Part 225... cycle to the next. Charges by an internal service activity to provide for the establishment and... allowable. A working capital reserve as part of retained earnings of up to 60 days cash expenses for...

  7. 40 CFR 1054.225 - How do I amend my application for certification to include new or modified engines or fuel...

    Science.gov (United States)

    2010-07-01

    ... certification to include new or modified engines or fuel systems or change an FEL? 1054.225 Section 1054.225....225 How do I amend my application for certification to include new or modified engines or fuel systems... include new or modified engine or fuel-system configurations, subject to the provisions of this...

  8. The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity

    International Nuclear Information System (INIS)

    Research highlights: → We examine the role of a ubiquitin-associated (UBA) domain in an E2 enzyme. → The E2-25K UBA domain directs polyubiquitin chain linkage specificity. → The E2-25K UBA domain regulates length of polyubiquitin chains synthesized. -- Abstract: E2-25K is an ubiquitin-conjugating enzyme with the ability to synthesize Lys48-linked polyubiquitin chains. E2-25K and its homologs represent the only known E2 enzymes which contain a C-terminal ubiquitin-associated (UBA) domain as well as the conserved catalytic ubiquitin-conjugating (UBC) domain. As an additional non-covalent binding surface for ubiquitin, the UBA domain must provide some functional specialization. We mapped the protein-protein interface involved in the E2-25K UBA/ubiquitin complex by solution nuclear magnetic resonance (NMR) spectroscopy and subsequently modeled the structure of the complex. Domain-domain interactions between the E2-25K catalytic UBC domain and the UBA domain do not induce significant structural changes in the UBA domain or alter the affinity of the UBA domain for ubiquitin. We determined that one of the roles of the C-terminal UBA domain, in the context of E2-25K, is to increase processivity in Lys48-linked polyubiquitin chain synthesis, possibly through increased binding to the ubiquitinated substrate. Additionally, we see evidence that the UBA domain directs specificity in polyubiquitin chain linkage.

  9. Immunoscintigraphy with anti-225.28S for ocular melanoma - a comparison with histology and immunohistochemistry

    International Nuclear Information System (INIS)

    Aim: The purpose of this prospective study was to evaluate the value of immunoscintigraphy (ISG) with anti-225.28S in clinically suspected ocular melanoma. Methods: For this purpose standardized ISG was performed in 36 patients using both planar acquisition and emission computed tomography (ECT). Ocular melanoma was present in 31 patients. In 21 patients therapy was enucleation of the eye. These specimens were evaluated by histology and immunohistochemistry in 11 of 21 patients. Results: Regarding the clinical diagnosis, ISG was positive only in 15 of 31 patients with ocular melanoma, regarding histology in 11 of 21 and regarding immunohistochemistry in 5 of 6 patients with a positive immunoreaction. 5 patients showed no immunoreactivity, their ISG was negative. Conclusion: Thus a good correlation between ISG and immunohistochemistry was observed. However ISG using the cutaneous melanoma antibody 225.28S cannot be recommended for the diagnostic work-up of an ocular melanoma considering the poor immunoreactivity. (orig.)

  10. 内地50家企业入选2009年ENR225

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009年9月5日,美国麦格劳·希尔建筑信息公司(McGraw—Hill)在其官方网站发布了2009年度ENR全球最大225家国际承包商排名,我国内地共有50家企业榜上有名。ENR的统计显示,全球225家最大国际承包商的海外经营业绩在2008年大幅飙升,完成海外营业额较上年度增长了25.7%。

  11. Which Option Pricing Model is the Best? High Frequency Data for Nikkei225 Index Options

    OpenAIRE

    Ryszard Kokoszczyński; Paweł Sakowski; Robert Ślepaczuk

    2010-01-01

    Option pricing models are the main subject of many research papers prepared both in academia and financial industry. Using high-frequency data for Nikkei225 index options, we check the properties of option pricing models with different assumptions concerning the volatility process (historical, realized, implied, stochastic or based on GARCH model). In order to relax the continuous dividend payout assumption, we use the Black model for pricing options on futures, instead of the Black-Scholes-M...

  12. Structure of quinoprotein methylamine dehydrogenase at 2.25 A resolution.

    OpenAIRE

    Vellieux, F. M.; Huitema, F; Groendijk, H; Kalk, K H; Jzn, J F; Jongejan, J.A.; Duine, J A; Petratos, K; DRENTH, J.; Hol, W. G.

    1989-01-01

    The three-dimensional structure of quinoprotein methylamine dehydrogenase from Thiobacillus versutus has been determined at 2.25 A resolution by a combination of multiple isomorphous replacement, phase extension by solvent flattening and partial structure phasing using molecular dynamics refinement. In the resulting map, the polypeptide chain for both subunits could be followed and an X-ray sequence was established. The tetrameric enzyme, made up of two heavy (H) and two light (L) subunits, i...

  13. Structure of liquid heavy water from 20 deg.C to 225 deg.C

    International Nuclear Information System (INIS)

    Recent results concerning the investigation of microscopic water properties by means of time of flight neutron diffraction are presented. It is found that the mean distance among water molecules increases with the decrease of water temperature. This implies an increase in local fourfold coordination due to the increase in 'hydrogen bonds'. Such behavior is observed in time-of-flight diffraction experiments using constant volume measurements for temperature range from +20 deg.C to 225 deg.C. (authors)

  14. Wind turbine test Vestas V27-225 kW

    Energy Technology Data Exchange (ETDEWEB)

    Markkilde Petersen, S.

    1990-10-15

    The report describes fundamental measurements performed on a Vestas-V27-225 kW pitch regulated wind turbine. The measurements carried out and reported here comprises the power output, system efficiency, energy production, transmission efficiency, rotor power, rotor efficiency, air-brakes efficiency, structural dynamics, loads at cut-in and braking, yaw error statistics, flapwise root bending moment and rotor thrust. (author).

  15. Cavity Formation in Aluminium Irradiated with a Pulsating Beam of 225 MeV Electrons

    DEFF Research Database (Denmark)

    Singh, Bachu Narain; Bilde-Sørensen, Jørgen; Leffers, Torben;

    1984-01-01

    High-purity aluminium was irradiated with a pulsating beam of 225 MeV electrons to a maximum dose of 0.035 dpa with a helium generation rate of up to 17 appm/dpa. The irradiated samples contained cavities in the size range 5 to 70 nm. In a zone of up to 14 μm from the grain boundaries cavity size...

  16. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Science.gov (United States)

    Dubey, R.; Sugathan, P.; Jhingan, A.; Kaur, Gurpreet; Mukul, Ish; Mohanto, G.; Siwal, D.; Saneesh, N.; Banerjee, T.; Thakur, Meenu; Mahajan, Ruchi; Kumar, N.; Chatterjee, M. B.

    2016-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30-50 MeV.

  17. Safety experience with IMC-C225, an anti-epidermal growth factor receptor antibody.

    Science.gov (United States)

    Needle, Michael N

    2002-10-01

    In phase II trials, the anti-epidermal growth factor receptor antibody IMC-C225 did not appear to significantly exacerbate the common toxicities associated with cytotoxic chemotherapy when combined with standard anticancer treatments in patients with colorectal cancer, squamous cell carcinoma of the head and neck, or pancreatic cancer. The most common treatment-related adverse events reported during therapy with IMC-C225 were an acne-like rash and hypersensitivity reactions. The acne-like rash appeared as a sterile, suppurative form of folliculitis, commonly starting on the face, scalp, chest, and upper back. It resolved without scarring once treatment was stopped. Notably, the appearance of acne-like rash, particularly grade 3, was associated with higher treatment responses in patients with refractory colorectal cancer. The hypersensitivity reactions occurred less often than acne-like rash. They responded to standard treatments and were less common after the first dose. In summary, IMC-C225 is generally well tolerated as a single agent and when combined with chemotherapy or radiotherapy and possesses a manageable toxicity profile.

  18. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    Directory of Open Access Journals (Sweden)

    R. Dubey

    2016-01-01

    Full Text Available Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F+206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30–50 MeV.

  19. Development of a Complex Geometry Standard Fixture and Solvent Evaluation Method fo Assessing Replacement Solvents for AK-225G Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The focus of this analysis was the development of a complex geometry test fixture and test method for determining solvent cleaning efficiency. AK-225 belongs to a...

  20. An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation

    International Nuclear Information System (INIS)

    A method for construction and operation of an 225Ac/213Bi generator capable of producing 25-100 mCi of 213Bi suitable for clinical antibody labeling is described. The generator has been designed to have an effective lifetime of several weeks, producing up to six therapeutic doses of radionuclide per day. To date, 57 clinical doses have been prepared and injected into patients using the described 213Bi generator. Factors such as radiation damage, radioprotection, iodide eluate chemistry, radiolabeling chemistry and radionuclidic purity are addressed

  1. Time history solution program, L225 (TEV126). Volume 1: Engineering and usage

    Science.gov (United States)

    Kroll, R. I.; Tornallyay, A.; Clemmons, R. E.

    1979-01-01

    Volume 1 of a two volume document is presented. The usage of the convolution program L225 (TEV 126) is described. The program calculates the time response of a linear system by convoluting the impulsive response function with the time-dependent excitation function. The convolution is performed as a multiplication in the frequency domain. Fast Fourier transform techniques are used to transform the product back into the time domain to obtain response time histories. A brief description of the analysis used is presented.

  2. Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles.

    Science.gov (United States)

    Wang, G; de Kruijff, R M; Rol, A; Thijssen, L; Mendes, E; Morgenstern, A; Bruchertseifer, F; Stuart, M C A; Wolterbeek, H T; Denkova, A G

    2014-02-01

    Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of (221)Fr and (213)Bi when encapsulating (225)Ac. PMID:24374072

  3. Laser-trapping of Ra-225 and Ra-226 with repumping by room temperature blackbody radiation

    OpenAIRE

    Guest, J R; Scielzo, N. D.; Ahmad, I.; Bailey, K.; Greene, J. P.; Holt, R J; Lu, Z. -T.; O'Connor, T. P.; Potterveld, D. H.

    2007-01-01

    We have demonstrated Zeeman slowing and capture of neutral Ra-225 and Ra-226 atoms in a magneto-optical trap (MOT). The intercombination transition 1S0-3P1 is the only quasi-cycling transition in radium and was used for laser-cooling and trapping. Repumping along the 3D1-1P1 transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable 3P0 level. We measured the isotope shift and hyperf...

  4. Production of chi mesons in 225 GeV/c π-Be interactions

    International Nuclear Information System (INIS)

    Gamma rays associated with psi mesons have been studied in 225 GeV/c π-Be interactions. The psi-γ mass spectrum shows an excess of 47 +- 11 events above background centered at 3.531 GeV/c2 with an rms width of 22.4 MeV. Attributing this excess of events to the decay chi → psi γ implies that 38 +- 9 % of all psi mesons are produced by this mechanism. The experimental setup and results are detailed

  5. Production of chi mesons in 225 GeV/c. pi. /sup -/Be interactions

    Energy Technology Data Exchange (ETDEWEB)

    Hossain, S.

    1981-09-01

    Gamma rays associated with psi mesons have been studied in 225 GeV/c ..pi../sup -/Be interactions. The psi-..gamma.. mass spectrum shows an excess of 47 +- 11 events above background centered at 3.531 GeV/c/sup 2/ with an rms width of 22.4 MeV. Attributing this excess of events to the decay chi ..-->.. psi ..gamma.. implies that 38 +- 9 % of all psi mesons are produced by this mechanism. The experimental setup and results are detailed.

  6. 225例成人麻疹临床特征及流行病学分析%Clinical features and epidemiological analysis of measles in 225 adult patients

    Institute of Scientific and Technical Information of China (English)

    卫峥; 张建中; 徐天敏

    2012-01-01

    目的 分析总结成人麻疹的临床特征,为临床工作积累经验.方法 回顾性分析2007年1月至2011年1月我院诊治的225例成人麻疹患者发病时间、职业、地区分布、疫苗接种史、接触史、临床表现,并发症及治疗转归等临床资料.结果 本组成人麻疹患者以发热、咳嗽、流涕、皮疹为主要临床表现,52%有麻疹接触史,96%麻疹病毒抗体阳性,90%肝功能异常.治疗以抗病毒和保肝对症治疗为主.并发症以肝损害、电解质紊乱多见,少数并发支气管炎、心肌炎.结论 近年成人麻疹病例呈增多趋势,且成人麻疹病情复杂,病程长,全身中毒症状重,易于并发肝损害,早期积极治疗是关键,预后良好.%Objective To analyze and summarize the clinical features of adult measles and accumulate experience for clinical work. Methods The clinical data of onset tune, occupation, geographical distribution, vaccination history, exposure history, clinical manifestations, complications and treatment outcome were retrospectively analyzed in 225 patients with adult measles in our hospital from Jan. 2007 to Jan. 2011. Results The main symptoms with adult measles patients were fever, cough, runny nose, and rash. 52% of the patients had a history of exposure to measles, 96% with measles virus-IgM positive, and 90% with liver dysfunction. Antiviral and symptomatic therapy was the main treatment strategy for measles. Complications such as liver damage, electrolyte disorders were more common, and a small number of patients were with bronchitis and myocarditis. Conclusion Adult measles cases showed an increasing trend in recent years, and complex condition, longer duration, heavy symptoms of systemic poisoning and easy to concurrent liver damage occurred. Early and active treatment is the key to a good prognosis.

  7. A theoretical model for the production of Ac-225 for cancer therapy by photon-induced transmutation of Ra-226.

    Science.gov (United States)

    Melville, G; Fan Liu, Sau; Allen, B J

    2006-09-01

    Radium needles that were once implanted into tumours as a cancer treatment are now obsolete and constitute a radioactive waste problem, as their half-life is 1600 years. We are investigating the reduction of radium by transmutation on a small scale by bombarding Ra-226 with high-energy photons from a medical linear accelerator (linac) to produce Ra-225, which subsequently decays to Ac-225, which can be used as a generator to produce Bi-213 for use in 'targeted alpha therapy' for cancer. This paper examines the possibility of producing Ac-225 with a linac using an accurate theoretical model in which the bremsstrahlung photon spectrum at 18 MV linac electron energy is convoluted with the corresponding photonuclear cross sections of Ra-226. The total integrated yield can then be obtained and is compared with a computer simulation. This study shows that at 18 MV, the photonuclear reaction on Ra-226 can produce low activities of Ac-225 with a linac. However, a high power linac with high current, pulse length and frequency is needed to produce practical amounts of Ac-225 and a useful reduction of Ra-226.

  8. Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200 MeV

    CERN Document Server

    Weidner, J W; John, K D; Hemez, F; Ballard, B; Bach, H; Birnbaum, E R; Bitteker, L J; Couture, A; Dry, D; Fassbender, M E; Gulley, M S; Jackman, K R; Ullmann, J L; Wolfsberg, L E; Nortier, F M

    2012-01-01

    Cross sections for 223,225Ra, 225Ac and 227Th production by the proton bombardment of natural thorium targets were measured at proton energies below 200 MeV. Our measurements are in good agreement with previously published data and offer a complete excitation function for 223,225Ra in the energy range above 90 MeV. Comparison of theoretical predictions with the experimental data shows reasonable-to-good agreement. Results indicate that accelerator-based production of 225Ac and 223Ra below 200 MeV is a viable production method.

  9. Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging

    Institute of Scientific and Technical Information of China (English)

    Dongbo Lin; Chunli Chen; Guangyuaa Hu; Qi Mei; Hong Qiu; Guoxian Long; Guoqing Hu

    2011-01-01

    An accurate definition of clinical target volume (CTV) is essential for the application of radiotherapy in nasopharvngeai carcinoma (NPC) treatment. A novel epidermal growth factor receptor (EGFR)-targeting contrast agent (C225-USPIO) was designed by conjugating ultrasmail superparamagnetic iron oxide (USPIO) nanoparticles with cetuximab (C225), to non-invasively define the CTV of tumor. The immunobinding activity of C225-USPIO to NPC cell line CNEI was confirmed by flow cytometry and immunofluorescence. The time-dependent accumulation of C225-USPIO in CNE1 cells was evaluated using Prussian blue staining. Targeted internalization and subcellular localization of C225-USPIO was confirmed by transmission electron microscope. The results indicated that C225-USPIO specifically bound to EGFR on the surface of CNEI cells and was taken up into the cell. The uptake of C225-USPIO by CNE1 cells increased significantly with time, when compared with human IgG-USPIO. In addition, 4.7 T magnetic resonance imaging (MRI) revealed that C225-USPIO had a capacity to accumulate in the CNE1 cells, with a resultant marked decrease in MRI T2-weighted signal intensity over time. These findings imply that C225-USPIO has the potential as an MRI contrast agent and can be employed to non-invasively detect early-stage NPC with EGFR overexpression. This provides sufficient theoretical basis for commencing in vivo experiments with the compound.

  10. Neutron-deuteron analyzing power data at En=22.5 MeV

    Science.gov (United States)

    Weisel, G. J.; Tornow, W.; Crowell, A. S.; Esterline, J. H.; Hale, G. M.; Howell, C. R.; O'Malley, P. D.; Tompkins, J. R.; Witała, H.

    2014-05-01

    We present measurements of n-d analyzing power, Ay(θ), at En=22.5 MeV. The experiment uses a shielded neutron source which produced polarized neutrons via the 2H(d⃗,n⃗)3He reaction. It also uses a deuterated liquid-scintillator center detector and six pairs of liquid-scintillator neutron side detectors. Elastic neutron scattering events are identified by using time-of-flight techniques and by setting a window in the center detector pulse-height spectrum. The beam polarization is monitored by using a high-pressure helium gas cell and an additional pair of liquid-scintillator side detectors. The n-d Ay(θ) data were corrected for finite-geometry and multiple-scattering effects using a Monte Carlo simulation of the experiment. The 22.5-MeV data demonstrate that the three-nucleon analyzing power puzzle also exists at this energy. They show a significant discrepancy with predictions of high-precision nucleon-nucleon potentials alone or combined with Tucscon-Melbourne or Urbana IX three-nucleon forces, as well as currently available effective-field theory based potentials of next-to-next-to-next-to-leading order.

  11. Interplay of fission modes in mass distribution of light actinide nuclei 225,227Pa

    CERN Document Server

    Dubey, R; Jhingan, A; Kaur, Gurpreet; Mukul, Ish; Mohanto, G; Siwal, D; Saneesh, N; Banerjee, T; Thakur, Meenu; Mahajan, Ruchi; Kumar, N; Chatterjee, M B

    2015-01-01

    Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F + 206, 208Pb around fusion barrier energies. Mass-angle correlations do not indicate any quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224, 226Th and 228U around barrier energies. Enhancement in mass variance of 225, 227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224, 226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential energy surfaces at low excitation energ...

  12. Challenges and opportunities in the search for electric dipole moment (EDM) in 225Ra atom

    Science.gov (United States)

    Kalita, Mukut; Bailey, Kevin; Dietrich, Matthew; Greene, John; Holt, Roy; Korsch, Wolfgang; Lu, Zheng-Tian; Mueller, Peter; O'Connor, Thomas; Parker, Richard; Sulai, Ibrahim; Singh, Jaideep

    2011-10-01

    The observation of a permanent electric dipole moment (EDM) in a non-degenerate system would indicate violation of time reversal symmetry. 225Ra atom is a particularly attractive candidate for this search since it has a nuclear spin I = 1/2 and has a significant nuclear octupole deformation. This property increases the Schiff moment of the nucleus and therefore enhances the atomic EDM. The half life (t1/2 = 14.9 days) of 225Ra is sufficiently long to perform EDM searches. Our group has already demonstrated the trapping of laser cooled Ra atoms in a magneto-optical trap (MOT) and transferring them to a far off resonant optical dipole trap (ODT). We will discuss our recent progress on manipulation of ultra cold Ra atoms in the ODT, efforts in improving our laser systems and generation of electric and magnetic fields required for the measurement. This work is supported by DOE, Office of Nuclear Physics, under contract No. DE-AC02-06CH11357 and contract No. DE-FG02-99ER41101.

  13. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer.

    Science.gov (United States)

    Herbst, Roy S; Hong, Waun Ki

    2002-10-01

    Squamous cell carcinoma of the head and neck remains a clinical challenge because of the high rate of locoregional disease recurrence. The importance of the epidermal growth factor receptor (EGFR) in the development and progression of many solid tumors, including squamous cell carcinoma of the head and neck, is well understood; increased expression is associated with enhanced tumor invasiveness, resistance to chemotherapy, and a lower patient survival rate. Several approaches have been developed to achieve EGFR blockade as an anticancer treatment strategy, including the anti-EGFR monoclonal antibody IMC-C225, which competitively binds to the extracellular receptor site and prevents binding by the natural EGFR ligands EGF and transforming growth factor-alpha. Preclinical studies to evaluate IMC-225 in human cancer cell lines in vitro and human tumor xenografts in vivo have shown its potent antitumor activity. Clinical efficacy of IMC-C225 appears to involve multiple mechanisms, including inhibition of cell cycle progression, induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, and enhancement of the response to chemotherapy and radiation therapy. Phase I studies of IMC-C225 combined with chemotherapy or radiation showed promising response rates in patients with recurrent or refractory squamous cell carcinoma of the head and neck. Phase II and III trials to examine the efficacy and safety of these combinations are currently underway. To date, IMC-C225 has been well tolerated, with skin rashes and allergic reactions being the most clinically important adverse events reported. IMC-C225 displays dose-dependent elimination characteristics and a half-life of approximately 7 days. Current recommendations for dosing include a 400 mg/m(2) loading dose, followed by weekly infusions at 250 mg/m(2).

  14. Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy

    International Nuclear Information System (INIS)

    Introduction: Targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as223Ra, 225Ra, and 225Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during their decay. Utilizing appropriate carriers capable of retaining both the parent radioisotope as well as daughter products is important for the effective delivery of the radioisotope to the tumor site while mitigating global in vivo radiotoxicity. In this work, LaPO4 core and core + 2 shells nanoparticles (NPs) (NPs with 2 layers of cold LaPO4 deposited on the core surfaces) were synthesized containing either 223Ra or225Ra/225Ac, and the retention of the parents and daughters within the NPs in vitro was investigated. Methods: Core LaPO4 NPs were synthesized in aqueous solution by reacting 1 equivalent of La(NO3)3, along with few microcuries of either 223Ra or 225Ra/225Ac, with 1 equivalent of sodium tripolyphosphate (TPP) under moderate heating and purified by membrane dialysis. Core-shell NPs were also synthesized with one (core + 1 shell) and two (core + 2 shells) cold LaPO4 layers deposited onto the radioactive cores. The NPs were then characterized by transmission electron microscopy (TEM) and powder x-ray diffraction (XRD). Identification and quantification of radioactive parents and daughters released from the NPs in vitro were investigated using gamma-ray spectroscopy. Results: XRD and TEM analysis revealed that the NPs crystallized in the rhabdophane phase with mean diameters of 3.4 and 6.3 nm for core and core + 2 shells, respectively. The core LaPO4 NPs retained up to 88% of 223Ra over 35 days. However, in the core + 2 shells NPs, the retention of 223Ra and its daughter, 211Pb, was improved to > 99.9% over 27 days. Additionally, the retention of 225Ra/225Ac parents was > 99.98% and ~ 80% for the 221Fr and 213Bi daughters over 35 days for the

  15. Stress corrosion cracking behavior of quenched and tempered 2.25Cr 1Mo steel

    International Nuclear Information System (INIS)

    For stress corrosion cracking (SCC) study of 2.25Cr-1Mo steel, speciemens were initially austenitized at 925 degree C for 2 hours and quenched in ice brine solution. With this process of heat treatment martensite was formed and banded morphology in the microstructure developed during previous processing was also removed. Tempering at 575 Degree C for 1h was employed to introduce ductility in the quenched martensite of the specimens. The effects of temperature variations on SCC behavior showed a successive decrease in strength and ductility of the steel. These variations in tensile properties were correlated with scanning electron microscopic (SEM) examinations. The SEM results clearly revealed that mostly transgranular cracks initiated at the edges of the tensile specimens grown perpendicular to loading axes, and their intensity is increased with the testing temperatures. (author)

  16. Laser trapping of 225Ra and 226Ra with repumping by room-temperature blackbody radiation.

    Science.gov (United States)

    Guest, J R; Scielzo, N D; Ahmad, I; Bailey, K; Greene, J P; Holt, R J; Lu, Z-T; O'Connor, T P; Potterveld, D H

    2007-03-01

    We have demonstrated Zeeman slowing and capture of neutral 225Ra and 226Ra atoms in a magneto-optical trap. The intercombination transition 1S0-->3P1 is the only quasicycling transition in radium and was used for laser-cooling and trapping. Repumping along the 3D1-->1P1 transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable 3P0 level. We measured the isotope shift and hyperfine splittings on the 3D1-->1P1 transition with the laser-cooled atoms, and set a limit on the lifetime of the 3D1 level based on the measured blackbody repumping rate. Laser-cooled and trapped radium is an attractive system for studying fundamental symmetries. PMID:17359153

  17. Laser-trapping of Ra-225 and Ra-226 with repumping by room temperature blackbody radiation

    CERN Document Server

    Guest, J R; Bailey, K; Greene, J P; Holt, R J; Lu, Z T; O'Connor, T P; Potterveld, D H; Scielzo, N D

    2007-01-01

    We have demonstrated Zeeman slowing and capture of neutral Ra-225 and Ra-226 atoms in a magneto-optical trap (MOT). The intercombination transition 1S0-3P1 is the only quasi-cycling transition in radium and was used for laser-cooling and trapping. Repumping along the 3D1-1P1 transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable 3P0 level. We measured the isotope shift and hyperfine splittings on the 3D1-1P1 transition with the laser-cooled atoms, and set a limit on the lifetime of the 3D1 level based on the measured blackbody repumping rate. Laser-cooled and trapped radium is an attractive system for studying fundamental symmetries.

  18. Stress corrosion cracking behavior of quenched and tempered 2.25Cr 1Mo steel

    Science.gov (United States)

    Manzoor, T.; Ahmad, E.; Sarwar, M.; Iqbal, M.

    2014-06-01

    For stress corrosion cracking (SCC) study of 2.25Cr-1Mo steel, specimens were initially austenitized at 925°C for 2 hours and quenched in ice brine solution. With this process of heat treatment martensite was formed and banded morphology in the microstructure developed during previous processing was also removed. Tempering at 575°C for 1h was employed to introduce ductility in the quenched martensite of the specimens. The effects of temperature variations on SCC behavior showed a successive decrease in strength and ductility of the steel. Theses variations in tensile properties were correlated with scanning electron microscopic (SEM) examinations. The SEM results clearly revealed that mostly transgranular cracks initiated at the edges of the tensile specimens grown perpendicular to loading axes, and their intensity is increased with the testing temperatures.

  19. NASA Rocket Propulsion Test Replacement Effort for Oxygen System Cleaner - Hydrochlorofluorocarbon (HCFC) 225

    Science.gov (United States)

    DeWitt Burns, H.; Mitchell, Mark A.; Lowrey, Nikki M.; Farner, Bruce R.; Ross, H. Richard

    2014-01-01

    Gaseous and liquid oxygen are extremely reactive materials used in bipropellant propulsion systems. Both flight and ground oxygen systems require a high level of cleanliness to support engine performance, testing, and prevent mishaps. Solvents used to clean and verify the cleanliness of oxygen systems and supporting test hardware must be compatible with the system's materials of construction and effective at removing or reducing expected contaminants to an acceptable level. This paper will define the philosophy and test approach used for evaluating replacement solvents for the current Marshall Space Flight Center/Stennis Space Center baseline HCFC-225 material that will no longer be available for purchase after 2014. MSFC/SSC applications in cleaning / sampling oxygen propulsion components, support equipment, and test system were reviewed then candidate replacement cleaners and test methods selected. All of these factors as well as testing results will be discussed.

  20. Seven to twelve year results with Versys ET cementless stem. A retrospective study of 225 cases.

    Science.gov (United States)

    D'Angelo, Fabio; Murena, Luigi; Vulcano, Ettore; Zatti, Giovanni; Cherubino, Paolo

    2010-01-01

    A retrospective review was conducted to evaluate the mid-term results (8.5 years follow-up) of the Versys ET stem (Zimmer, Warsaw, Indiana, USA). From 1995 to 2000, 225 total hip arthroplasties (THA) were performed using this device. All patients were evaluated clinically by the Harris Hip Score, and radiographically. The Hip Score increased from 54 preoperatively to 97 points postoperatively. The stem displayed a varus alignment between 5 degrees and 10 degrees in 17 cases without any clinical consequences (HHS 96.8). We recorded one case of septic loosening and one case of aseptic loosening. The stability of the stem was radiographically evaluated according to Engh's criteria, confirming bone ongrowth in all other cases. PMID:20235069

  1. Welded joint properties of 08Cr2.25Mo1NiNb type steel

    International Nuclear Information System (INIS)

    The results are given of a study into the effect of the chemical composition on the mechanical and structural properties of welded joint of steel 08Cr2.25Mo1NiNb. The welded joints were obtained by manual arc welding using coated electrodes. For assessing short-term strength and plastic properties, tensile tests at normal temperature, notch toughness tests, hardness measurements and bending tests were conducted. The welded joint microstructure was also analysed. The minimal values of the yield point can be obtained in welded joints of melts with the Nb content at a level of the stabilization ratio. The highest hardness values were obtained in the welding metal ranges, which, however, does not negatively affect the plastic properties of the joint. Lower values of notch toughness were found for welding metals with higher carbon content. (M.S.)

  2. 12 CFR 225.88 - How to request the Board to determine that an activity is financial in nature or incidental to a...

    Science.gov (United States)

    2010-01-01

    ... activity is financial in nature or incidental to a financial activity? 225.88 Section 225.88 Banks and... request the Board to determine that an activity is financial in nature or incidental to a financial activity? (a) Requests regarding activities that may be financial in nature or incidental to a...

  3. 41 CFR 302-3.225 - If my immediate family member(s) return to the U.S. before me, will I be reimbursed for...

    Science.gov (United States)

    2010-07-01

    ... ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types of Transfers Prior Return of Immediate Family... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false If my immediate family... with my family and the rest of my household goods when I return? 302-3.225 Section 302-3.225...

  4. 20 CFR 30.225 - What are the criteria for eligibility for benefits under Part B of EEOICPA for certain uranium...

    Science.gov (United States)

    2010-04-01

    ... benefits under Part B of EEOICPA for certain uranium employees? 30.225 Section 30.225 Employees' Benefits... COMPENSATION PROGRAM ACT OF 2000, AS AMENDED Eligibility Criteria Eligibility Criteria for Certain Uranium... of EEOICPA for certain uranium employees? In order to be eligible for benefits under this...

  5. 43 CFR 2.25 - How will a bureau handle a request for Federally-funded research data in the possession of a...

    Science.gov (United States)

    2010-10-01

    ... Federally-funded research data in the possession of a private entity? 2.25 Section 2.25 Public Lands... findings are used by a bureau in developing an agency action, e.g., a policy or regulation, research data... for such research data, the bureau will require the recipient to provide the information to it...

  6. 45 CFR 1173.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-10-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 45 Public Welfare 3 2010-10-01 2010-10-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 1173.225 Section 1173.225 Public...

  7. 28 CFR 83.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-07-01

    ... employees who are convicted of drug violations in the workplace? 83.225 Section 83.225 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS... are convicted of drug violations in the workplace? There are two actions you must take if an...

  8. 13 CFR 147.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-01-01

    ... concerning employees who are convicted of drug violations in the workplace? 147.225 Section 147.225 Business... employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies...

  9. 22 CFR 1008.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-04-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 22 Foreign Relations 2 2010-04-01 2010-04-01 true What actions must I take concerning employees who are convicted of drug violations in the workplace? 1008.225 Section 1008.225 Foreign...

  10. 45 CFR 1155.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-10-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 45 Public Welfare 3 2010-10-01 2010-10-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 1155.225 Section 1155.225 Public...

  11. 15 CFR 29.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-01-01

    ... employees who are convicted of drug violations in the workplace? 29.225 Section 29.225 Commerce and Foreign... employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies...

  12. 24 CFR 21.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-04-01

    ... employees who are convicted of drug violations in the workplace? 21.225 Section 21.225 Housing and Urban... actions must I take concerning employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a)...

  13. 41 CFR 105-74.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-07-01

    ... concerning employees who are convicted of drug violations in the workplace? 105-74.225 Section 105-74.225... workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies if an employee who is engaged in the performance...

  14. 38 CFR 48.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-07-01

    ... concerning employees who are convicted of drug violations in the workplace? 48.225 Section 48.225 Pensions... What actions must I take concerning employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace:...

  15. 21 CFR 1405.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-04-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 21 Food and Drugs 9 2010-04-01 2010-04-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 1405.225 Section 1405.225 Food and Drugs OFFICE...

  16. 10 CFR 607.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-01-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 10 Energy 4 2010-01-01 2010-01-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 607.225 Section 607.225 Energy DEPARTMENT OF...

  17. 34 CFR 84.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-07-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 34 Education 1 2010-07-01 2010-07-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 84.225 Section 84.225 Education Office of the...

  18. 20 CFR 439.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 439.225 Section 439.225 Employees' Benefits... are convicted of drug violations in the workplace? There are two actions you must take if an...

  19. 2 CFR 182.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-01-01

    ... employees who are convicted of drug violations in the workplace? 182.225 Section 182.225 Grants and... the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies if an employee who is engaged in...

  20. 40 CFR 36.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-07-01

    ... employees who are convicted of drug violations in the workplace? 36.225 Section 36.225 Protection of... workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies if an employee who is engaged in the performance...

  1. 36 CFR 1212.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-07-01

    ... concerning employees who are convicted of drug violations in the workplace? 1212.225 Section 1212.225 Parks... workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must notify Federal agencies if an employee who is engaged in the performance...

  2. 14 CFR 1267.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-01-01

    ... employees who are convicted of drug violations in the workplace? 1267.225 Section 1267.225 Aeronautics and... concerning employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must...

  3. 49 CFR 32.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-10-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 49 Transportation 1 2010-10-01 2010-10-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 32.225 Section 32.225 Transportation Office of...

  4. 22 CFR 133.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-04-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 22 Foreign Relations 1 2010-04-01 2010-04-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 133.225 Section 133.225 Foreign...

  5. 43 CFR 43.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-10-01

    ... employees who are convicted of drug violations in the workplace? 43.225 Section 43.225 Public Lands... concerning employees who are convicted of drug violations in the workplace? There are two actions you must take if an employee is convicted of a drug violation in the workplace: (a) First, you must...

  6. 22 CFR 1509.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-04-01

    ... are convicted of drug violations in the workplace? There are two actions you must take if an employee... 22 Foreign Relations 2 2010-04-01 2010-04-01 true What actions must I take concerning employees who are convicted of drug violations in the workplace? 1509.225 Section 1509.225 Foreign...

  7. A novel multifunctional nanocomposite C225-conjugated Fe3O4/Ag enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy

    Institute of Scientific and Technical Information of China (English)

    Di Zhao; Xinchen Sun; Jinglong Tong; Jun Ma; Xiaodong Bu; Ruizhi Xu; Renhua Fan

    2012-01-01

    Radiotherapy is the major treatment for nasopharyngeal carcinoma,a malignant tumor of epithelial origin.In this process,a tracer with high sensitivity is pivotal for diagnostic imaging in radiotherapy.Here,we designed a novel muitifunctional magnetic silver nanocomposite,Fe3O4/Ag conjugated to an epidermal growth factor receptor-specific antibody (C225),which can be potentially used for synchronous cancer therapy and diagnosis via magnetic resonance imaging.Characteristics of Fe3O4/Ag/C225 were determined by transmission electron microscopy,energy dispersive X-ray spectroscopy,ultraviolet spectra,and dynamic light scattering.The results demonstrated that Fe3O4/Ag/C225 nanoparticles were spherical and dispersed well in water.The activity of C225 was preserved~80% in the Fe3O4/Ag/C225 nanoparticles.Futhermore,we tested the cytotoxicity and radiosensitivity of the nanocomposite for human nasopharyngeal carcinoma cell lines (CNEs) in vitro.MTT analysis revealed that Fe3O4/Ag/C225 could inhibit the proliferation of CNEs in a dose-and timedependent manner.The clonogenic assay indicated that Fe3O4/Ag/C225 combined with X-ray treatment could increase the sensitivity of CNEs to irradiation.In a summary,the novel multifunctional nanocomposite Fe3O4/Ag/C225 might be a potential radiosensitizer for treating malign tumors in the clinic.

  8. 12 CFR 225.176 - How do the statutory cross marketing and sections 23A and B limitations apply to merchant banking...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false How do the statutory cross marketing and sections 23A and B limitations apply to merchant banking investments? 225.176 Section 225.176 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK...

  9. 31 CFR 20.225 - What actions must I take concerning employees who are convicted of drug violations in the workplace?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false What actions must I take concerning employees who are convicted of drug violations in the workplace? 20.225 Section 20.225 Money and Finance... abuse assistance or rehabilitation program approved for these purposes by a Federal, State or...

  10. Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization.

    Science.gov (United States)

    Pandya, Darpan N; Hantgan, Roy; Budzevich, Mikalai M; Kock, Nancy D; Morse, David L; Batista, Izadora; Mintz, Akiva; Li, King C; Wadas, Thaddeus J

    2016-01-01

    The theranostic potential of (225)Ac-based radiopharmaceuticals continues to increase as researchers seek innovative ways to harness the nuclear decay of this radioisotope for therapeutic and imaging applications. This communication describes the evaluation of (225)Ac-DOTA-c(RGDyK) in both biodistribution and Cerenkov luminescence imaging (CLI) studies. Initially, La-DOTA-c(RGDyK) was prepared as a non-radioactive surrogate to evaluate methodologies that would contribute to an optimized radiochemical synthetic strategy and estimate the radioactive conjugate's affinity for αvβ3, using surface plasmon resonance spectroscopy. Surface plasmon resonance spectroscopy studies revealed the IC50 and Ki of La-DOTA-c(RGDyK) to be 33 ± 13 nM and 26 ± 11 nM, respectively, and suggest that the complexation of the La(3+) ion to the conjugate did not significantly alter integrin binding. Furthermore, use of this surrogate allowed optimization of radiochemical synthesis strategies to prepare (225)Ac-DOTA-c(RGDyK) with high radiochemical purity and specific activity similar to other (225)Ac-based radiopharmaceuticals. This radiopharmaceutical was highly stable in vitro. In vivo biodistribution studies confirmed the radiotracer's ability to target αvβ3 integrin with specificity; specificity was detected in tumor-bearing animals using Cerenkov luminescence imaging. Furthermore, tumor growth control was achieved using non-toxic doses of the radiopharmaceutical in U87mg tumor-bearing nude mice. To our knowledge, this is the first report to describe the CLI of αvβ3 (+) tumors in live animals using the daughter products derived from (225)Ac decay in situ. This concept holds promise to further enhance development of targeted alpha particle therapy.

  11. Preliminary Therapy Evaluation of 225Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from 225Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization

    Science.gov (United States)

    Pandya, Darpan N.; Hantgan, Roy; Budzevich, Mikalai M.; Kock, Nancy D.; Morse, David L.; Batista, Izadora; Mintz, Akiva; Li, King C.; Wadas, Thaddeus J.

    2016-01-01

    The theranostic potential of 225Ac-based radiopharmaceuticals continues to increase as researchers seek innovative ways to harness the nuclear decay of this radioisotope for therapeutic and imaging applications. This communication describes the evaluation of 225Ac-DOTA-c(RGDyK) in both biodistribution and Cerenkov luminescence imaging (CLI) studies. Initially, La-DOTA-c(RGDyK) was prepared as a non-radioactive surrogate to evaluate methodologies that would contribute to an optimized radiochemical synthetic strategy and estimate the radioactive conjugate's affinity for αvβ3, using surface plasmon resonance spectroscopy. Surface plasmon resonance spectroscopy studies revealed the IC50 and Ki of La-DOTA-c(RGDyK) to be 33 ± 13 nM and 26 ± 11 nM, respectively, and suggest that the complexation of the La3+ ion to the conjugate did not significantly alter integrin binding. Furthermore, use of this surrogate allowed optimization of radiochemical synthesis strategies to prepare 225Ac-DOTA-c(RGDyK) with high radiochemical purity and specific activity similar to other 225Ac-based radiopharmaceuticals. This radiopharmaceutical was highly stable in vitro. In vivo biodistribution studies confirmed the radiotracer's ability to target αvβ3 integrin with specificity; specificity was detected in tumor-bearing animals using Cerenkov luminescence imaging. Furthermore, tumor growth control was achieved using non-toxic doses of the radiopharmaceutical in U87mg tumor-bearing nude mice. To our knowledge, this is the first report to describe the CLI of αvβ3+ tumors in live animals using the daughter products derived from 225Ac decay in situ. This concept holds promise to further enhance development of targeted alpha particle therapy. PMID:27022417

  12. 76 FR 70531 - Fifth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

    Science.gov (United States)

    2011-11-14

    ... Federal Aviation Administration Fifth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice to advise...

  13. 77 FR 66084 - Tenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

    Science.gov (United States)

    2012-11-01

    ... Federal Aviation Administration Tenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  14. 77 FR 56253 - Ninth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems-Small...

    Science.gov (United States)

    2012-09-12

    ... Federal Aviation Administration Ninth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice...

  15. 12 CFR 225.14 - Expedited action for certain bank acquisitions by well-run bank holding companies.

    Science.gov (United States)

    2010-01-01

    ...-capitalized organization—(i) Bank holding company. Both at the time of and immediately after the proposed... acquiring bank holding company is undercapitalized; (2) Well managed organization—(i) Satisfactory... required and public notice. As an alternative to the procedure provided in § 225.15, a bank holding...

  16. 40 CFR 1068.225 - What are the provisions for exempting engines/equipment for national security?

    Science.gov (United States)

    2010-07-01

    ... PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS GENERAL COMPLIANCE PROVISIONS FOR ENGINE PROGRAMS... following items: (1) The label heading “EMISSION CONTROL INFORMATION”. (2) Your corporate name and trademark... ENGINE HAS AN EXEMPTION FOR NATIONAL SECURITY UNDER 40 CFR 1068.225.” (ii) “THIS EQUIPMENT HAS...

  17. 20 CFR 225.54 - Recomputation when an employee is eligible for periodic pension payments based on other than...

    Science.gov (United States)

    2010-04-01

    ... for periodic pension payments based on other than railroad or social security earnings. 225.54 Section... eligible for periodic pension payments based on other than railroad or social security earnings. (a) Description. This recomputation serves as a reduction in the PIA for entitlement to a periodic pension...

  18. 75 FR 79312 - Special Conditions: Eurocopter France (ECF) Model EC225LP Helicopter, Installation of a Search...

    Science.gov (United States)

    2010-12-20

    ... information, utilizing OEI continuous and time-limited power ratings. (C) The maximum wind envelope... Federal Aviation Administration 14 CFR Part 29 Special Conditions: Eurocopter France (ECF) Model EC225LP.... Special conditions No. 29-022-SC, published in the Federal Register on November 6, 2008 (73 FR...

  19. 77 FR 60883 - Special Conditions: Eurocopter France (ECF) Model EC225LP Helicopter, Installation of a Search...

    Science.gov (United States)

    2012-10-05

    ... information, utilizing OEI continuous and time-limited power ratings. (C) The maximum wind envelope... Administration 14 CFR Part 29 Special Conditions: Eurocopter France (ECF) Model EC225LP Helicopter, Installation... published in the Federal Register on November 6, 2008 (73 FR 65968). A notice proposing this amendment...

  20. 48 CFR 52.225-4 - Buy American Act-Free Trade Agreement-Israeli Trade Act Certificate.

    Science.gov (United States)

    2010-10-01

    ... CLAUSES Text of Provisions and Clauses 52.225-4 Buy American Act—Free Trade Agreement—Israeli Trade Act... product,” “foreign end product,” “Free Trade Agreement country,” “Free Trade Agreement country end product... American Act—Free Trade Agreements—Israeli Trade Act.” (b) The offeror certifies......

  1. The Plant-Derived Chalcone 2,2',5'-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia.

    Science.gov (United States)

    Jiwrajka, Manasi; Phillips, Alexandra; Butler, Matt; Rossi, Miriam; Pocock, Jennifer M

    2016-01-01

    Chalcones are plant metabolites with potential for therapeutic exploitation as antioxidant, anti-inflammatory, and antiproliferative agents. Here we explored the neuroprotective effects of 2,2',5'-trihydroxychalcone (225THC), a potent antioxidant with radical-scavenging properties. 225THC was found to be a potent inhibitor of apoptosis in stimulated primary rat neuronal cultures. This was likely mediated by an anti-inflammatory effect on microglial cells since 225THC inhibited LPS-stimulated TNF-α and IL-6 secretion from primary rat microglia and modulated the cytokine/chemokine profile of BV2 microglial cells. Additionally, 225THC inhibited LPS-evoked inducible nitric oxide synthase expression but did not influence endogenous superoxide generation. Microglial flow cytometric analyses indicated the 225THC treatment induced a shift from an M1-like phenotype to a more downregulated microglial profile. Taken together these data suggest that the chalcone 2,2',5'-trihydroxychalcone can modulate neuroinflammatory activation in brain-derived microglia and holds promise as a therapeutic in neuroinflammatory conditions.

  2. Efficacy of the National Football League-225 Test to Track Changes in One Repetition Maximum Bench Press After Training in National Collegiate Athletic Association Division IA Football Players.

    Science.gov (United States)

    Mann, J Bryan; Ivey, Pat A; Stoner, Josh D; Mayhew, Jerry L; Brechue, William F

    2015-11-01

    Numerous investigations have attested to the efficacy of the National Football League (NFL)-225 test to estimate one repetition maximum (1RM) bench press. However, no studies have assessed the efficacy of the test to track changes in strength across a training program. The purpose of this study was to determine the accuracy of the NFL-225 test for determining the change in 1RM bench press in National Collegiate Athletic Association Division IA college football players after training. Over a 4-year period, players (n = 203) were assessed before and after a 6-week off-season resistance program for 1RM bench press and repetitions completed with 102.3 kg (225 lbs). Test sessions typically occurred within 1 week of each other. Players significantly increased 1RM by 4.2 ± 8.6 kg and NFL-225 repetitions by 0.9 ± 2.3, although the effect size (ES) for each was trivial (ES = 0.03 and 0.07, respectively). National Football League 225 prediction equations had higher correlations with 1RM before training (intraclass correlation coefficient [ICC] = 0.95) than after training (ICC = 0.75). The correlation between the change in NFL-225 repetitions and change in 1RM was low and negative (r = -0.22, p football players and render the NFL-225 test less effective in predicting the change in 1RM bench press strength after short-term training.

  3. Failure Analysis of Resonance Induced by Von Karman Vortex Shedding from Runner Blades for Dachaoshan 225MW Hydro Unit%大朝山电站225MW水轮机转轮卡门涡共振分析

    Institute of Scientific and Technical Information of China (English)

    石清华; 尹国军

    2005-01-01

    分析了云南大朝山电站225MW水轮发电机组运行时发生卡门涡共振,产生金属蜂鸣声及叶片裂纹的原因,经分析处理并取得成功,为大型水轮机的安全运行提供了经验.图4表2

  4. Production of charmonium states in 225 GeV/c pi-minus beryllium interactions

    International Nuclear Information System (INIS)

    This thesis reports on the analysis of data obtained during the FNAL experiment E610. The Chicago Cyclotron Magnet Spectrometer was used to perform a study of the hadronic production of charmonium. A 225 GeV/c negative pion beam was incident on a beryllium target. The trigger required a dimuon signature which favored opposite sign muon pairs with a large combined p/sub tau/. A search was then made for chi mesons of the charmonium spectrum by combining J/psi mesons found in the dimuon spectrum with photons detected in a large lead glass shower detector. These events were used to determine the fraction of J/psis produced from chis. A psi(3685) signal seen in the dimuon spectrum was used to determine the fraction of J/psis resulting from psi(3685). Assuming that these are the only particles decaying to J/psi, we obtain the fraction of J/psis produced directly in hadronic collisions - 0.58 +- 0.09 - which is relevant to the production mechanism for charmonium in strong interactions

  5. 3.5-Year Monitoring of 225 GHz Opacity at the Summit of Greenland

    CERN Document Server

    Matsushita, Satoki; Martin-Cocher, Pierre L; Chen, Ming-Tang; Ho, Paul T P; Inoue, Makoto; Koch, Patrick M; Paine, Scott N; Turner, David D

    2016-01-01

    We present the 3.5-yr monitoring results of 225 GHz opacity at the summit of the Greenland ice sheet (Greenland Summit Camp) at an altitude of 3200 m using a tipping radiometer. We chose this site as our submillimeter telescope (Greenland Telescope; GLT) site, because its location offers favorable baselines to existing submillimeter telescopes for global-scale VLBI. The site shows a clear seasonal variation with the average opacity lower by a factor of two during winter. For the winter quartiles of 25% and 50%, the Greenland site is about 10%-30% worse than the ALMA or the South Pole sites. Estimated atmospheric transmission spectra in winter season are similar to the ALMA site at lower frequencies (450 GHz) than those at the ALMA site. This is due to the lower altitude of the Greenland site. Nevertheless, half of the winter time at the Greenland site can be used for astronomical observations at frequencies between 450 GHz and 1000 GHz with opacities 10% transmittance in the THz (1035 GHz, 1350 GHz, and 1500 ...

  6. Magnetically Dominated Parallel Interstellar Filaments at the Infrared Dark Cloud G14.225-0.506

    CERN Document Server

    Santos, Fabio P; Franco, Gabriel A P; Girart, Josep M; Zhang, Qizhou

    2016-01-01

    The G14.225-0.506 infrared dark cloud (IRDC G14.2) displays a remarkable complex of parallel dense molecular filaments projected on the plane of the sky. Previous dust emission and molecular-line studies have speculated whether magnetic fields could have played an important role in the formation of such long-shaped structures, which are hosts to numerous young stellar sources. In this work we have conducted a vast polarimetric survey at optical and near-infrared wavelengths in order to study the morphology of magnetic field lines in IRDC G14.2 through the observation of background stars. The orientation of interstellar polarization, which traces magnetic field lines, is perpendicular to most of the filamentary features within the cloud. Additionally, the larger-scale molecular cloud as a whole exhibits an elongated shape also perpendicular to magnetic fields. Estimates of magnetic field strengths indicate values in the range $320 - 550\\,\\mu$G, which allows sub-alfv\\'enic conditions, but does not prevent the g...

  7. Production of charmonium states in 225 GeV/c π-minus beryllium interactions

    International Nuclear Information System (INIS)

    This thesis reports on the analysis of data obtained during FNAL experiment E610. The Chicago Cyclotron Magnet Spectrometer was used to perform a study of the hadronic production of charmonium. A 225 GeV/c negative pion beam was incident on a beryllium target. The trigger required a dimuon signature which favored opposite sign muon pairs with a large combined p/sub tau/. A search was then made for chi mesons of the charmonium spectrum by combining J/psi mesons found in the dimuon spectrum with photons detected in a large lead glass shower detector. These events were used to determine the fraction of J/psi s produced from chi s. A psi(3685) signal seen in the dimuon spectrum was used to determine the fraction of J/psi s resulting from psi(3685). Assuming that these are the only particles decaying to J/psi, we obtain the fraction of J/psi s produced directly in hadronic collisions - 0.58 +- 0.09 - which is relevant to the production mechanism for charmonium in strong interactions

  8. Electric dipole moment of $^{225}$Ra due to P- and T-violating weak interactions

    CERN Document Server

    Singh, Yashpal

    2015-01-01

    We report rigorous calculations of electric dipole moment (EDM) in $^{225}$Ra due to parity and time-reversal violating tensor-pseudotensor (T-PT) and nuclear Schiff moment (NSM) interactions between the electrons and nucleus by employing the relativistic all order coupled-cluster (RCC) methods at various levels of approximation. The most accurate EDM ($d_A$) results are obtained as $d_A=-10.04\\times 10^{-20} C_T |e|cm$ and $d_A^{NSM}=-6.79 \\times 10^{-17} S (|e|fm^3)^{-1} |e|cm$ with $C_T$ and $S$ are the T-PT coupling constant and NSM respectively. Due to exhaustive treatment of the electron correlation effects in these calculations, the EDM results for the corresponding T-PT and NSM interactions reduce by about 45\\% and 23\\%, respectively, from the previously known values. Nonetheless they are still found to be 2-3 times larger than the $^{199}$Hg results. Validity of the RCC results are countenanced by comparing our calculations at the zeroth order Dirac-Fock method and all order random-phase approximatio...

  9. Underwater Laser-illuminated Range-gated Imaging Scaled by 22.5 cm ns-1 with Serial Targets

    Institute of Scientific and Technical Information of China (English)

    HE Duo-Min

    2004-01-01

    We have developed a novel target set to scale our Underwater Laser-illuminated Range-gated Imaging(ULRI)video system in a 3 m-tank with turbid water(attenuation coefficient 1.0 m-1). As light speed in water is 22.5 cm ns-1, the target set consists of a series of 3-bar targets at 22.5 cm intervals along the laser illumination direction, with the targets separated vertically. As a result, a sequence of good gated images, in steps of 1 ns delay, is presented, which is a revelation of the' sliced-view' phenomenon for ns-level range-gating in such a limited water body. The Depth of Gating(DOG)and DOG-profile of the URLI system are measured for the first time, which can be used for evaluating gating-performance efficiently.

  10. KINETICS OF TEMPER EMBRITTLEMENT IN 2.25Cr-1Mo STEEL USED FOR HOT-WALL HYDROFINING REACTORS

    Institute of Scientific and Technical Information of China (English)

    J.Z.Tan

    2004-01-01

    Based on the theory of grain boundary segregation,a kinetics model of temper embrittlement caused by long-term service for hot-wall hydrofining reactors was studied.The kinetics model was applied to phosphorus(P)segregation in 2.25Cr-1Mo steel used for a hot-wall hydrofining reactor,and the kinetics of grain boundary segregation of impurity P in the steel exposed to the process environment of the hydrofining reactor was calculated on the basis of the model.The Auger electron spectroscopy test was performed in order to determine the grain boundary concentration of P.The experimental result is agreement with the theoretical calculated data.The results show that the kinetics equation is reasonable for predicting the levels of grain boundary segregation of impurity P in 2.25Cr-1Mo steel used for hot-wall hydrofining reactors.

  11. 蓝色巨人再出重拳 IBM xSeries 225出走江湖

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    xSeries 225使用10/100M自适应以太网卡+1000M自适应以太网卡、ATA100的IDE设备,Ultra 320 SCSI、CDROM支持Microsoft Windows 2000.Windows NT、Novell NetWare.Linux、SCO UnixWare.SCO OpenServer等操作系统三年保修。

  12. Performance characteristics of automotive engines in the United States: Report No. 9, Chrysler (1975) 225-CID 1-bbl engine

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, W.F.; Stamper, K.R.

    1977-08-01

    Experimental data were obtained in dynamometer tests of a 1975 Chrysler 225-CID, 1-bbl engine to determine fuel consumption and emissions (hydrocarbon, carbon monoxide, and oxides of nitrogen) at steady-state engine operating modes. The objective of the program is to obtain engine performance data for estimating emissions and fuel economy for varied engine service and duty. The intent of the work is to provide basic engine characteristic data required as input for engineering calculations involving ground transportation.

  13. Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2)

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Randall C.; Hughes, Ronny C.; Flatt, Justin W.; Meehan, Edward J.; Ng, Joseph D.; Twigg, Pamela D.; (UAH)

    2009-08-07

    The ubiquitin-conjugating enzyme E2-25K has been identified as a huntingtin (the key protein in Huntington's disease) interacting protein and has been shown to play a role in mediating the toxicity of A{beta}, the principal protein involved in Alzheimer's disease pathogenesis. E2-25K is a dual-domain protein with an ubiquitin-associated (UBA) domain as well as a conserved ubiquitin-conjugating (UBC) domain which catalyzes the formation of a covalent bond between the C-terminal glycine of an ubiquitin molecule and the {var_epsilon}-amine of a lysine residue on the acceptor protein as part of the ubiquitin-proteasome pathway. The crystal structures of E2-25K M172A mutant protein at pH 6.5 and pH 8.5 were determined to 1.9 and 2.2 {angstrom} resolution, respectively. Examination of the structures revealed domain-domain interactions between the UBC and UBA domains which have not previously been reported

  14. Microstructural Evolution of 2.25Cr-1.6W-V-Nb Heat Resistant Steel during Creep

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    2.25Cr-1.6W-V-Nb developed in Japan, is a low alloy heat resistant steel with good comprehensive properties. Influence of long term creep at elevated temperature on the structure of 2.25Cr-1.6W-V-Nb steel was studied in this paper, and the micromechanism of creep strength degradation was elucidated, too. Both TEM observation and thermodynamic calculation reveal that during creep the transformation occurs from M7C3 and M23C6 to M6C,which can be cavity nucleation sites. Besides, creep at 600℃ also leads to the decrease of dislocation density, the coarsening and coalescence of M23C6, the nucleation of cavities and development of cracks. The strength decrease of 2.25Cr-1.6W-V-Nb steel after long term creep is related to the decrease of dislocation hardening, precipitation hardening, solution hardening, the nucleation of cavities and development of cracks.

  15. Water availability and vulnerability of 225 large cities in the United States

    Science.gov (United States)

    Padowski, Julie C.; Jawitz, James W.

    2012-12-01

    This study presents a quantitative national assessment of urban water availability and vulnerability for 225 U.S. cities with population greater than 100,000. Here, the urban assessments account for not only renewable water flows, but also the extracted, imported, and stored water that urban systems access through constructed infrastructure. These sources represent important hydraulic components of the urban water supply, yet are typically excluded from water scarcity assessments. Results from this hydraulic-based assessment were compared to those obtained using a more conventional method that estimates scarcity solely based on local renewable flows. The inclusion of hydraulic components increased the mean availability to cities, leading to a significantly lower portion of the total U.S. population considered "at risk" for water scarcity (17%) than that obtained from the runoff method (47%). Water vulnerability was determined based on low-flow conditions, and smaller differences were found for this metric between at-risk populations using the runoff (66%) and hydraulic-based (54%) methods. The large increase in the susceptible population between the scarcity measures evaluated using the hydraulic method may better reconcile the seeming contradiction in the United States between perceptions of natural water abundance and widespread water scarcity. Additionally, urban vulnerability measures developed here were validated using a media text analysis. Vulnerability assessments that included hydraulic components were found to correlate with the frequency of urban water scarcity reports in the popular press while runoff-based measures showed no significant correlation, suggesting that hydraulic-based assessments provide better context for understanding the nature and severity of urban water scarcity issues.

  16. BWR shutdown and startup chemistry experience and application Sourcebook. BWRVIP-225, Rev. 1

    International Nuclear Information System (INIS)

    BWR water chemistry has changed significantly over the years with the adoption of hydrogen water chemistry (HWC), noble metal chemical application (NMCA), and most recently, Online NobleChem™ (OLNC). Some plants have experienced large increases in activated corrosion products during shutdown evolutions, when the chemistry environment at primary system surfaces transitions from reducing to oxidizing conditions. Higher activity releases may be in part related to the more reducing conditions brought about by the above mentioned processes during the operating cycle. With shorter outages decreasing the available cleanup time, some plants are experiencing increased outage radiation exposure. A significant portion of fuel cycle intergranular stress corrosion cracking (IGSCC) propagation of reactor internals and primary system piping is indicated to occur during startup and early power ascension, when dissolved oxygen and hydrogen peroxide concentrations in the reactor coolant are high and hydrogen injection is unavailable. The majority of lost hydrogen availability hours typically occurs during early startup. Startup periods following refueling outages are also when reactor coolant chemistry transients may occur due to system flow changes and residual chemical impurities from outage related work activities. Test results show that IGSCC is accelerated particularly during early startup periods of elevated reactor coolant oxidant concentrations (dissolved oxygen and hydrogen peroxide), particularly when operating at an intermediate temperature range (300 – 400°F, 148-204°C). Based on extensive data collection and evaluation, BWRVIP-225 Revision 1 provides good practices and conditions to avoid during plant refueling outages, including recommendations to minimize activity transport during shutdown conditions to reduce radiation exposure. In addition, good practices and conditions to avoid are provided for startup and power ascension to minimize IGSCC. This paper

  17. Role of EGFR inhibitor C225 in cerebral inflammation of fetal rats of intrauterine infection%EGFR抑制剂C225在宫内感染仔鼠脑组织炎症中的实验研究

    Institute of Scientific and Technical Information of China (English)

    桑鑫泉; 程远; 李多多; 柳晓燕; 朱凤莲

    2015-01-01

    目的 研究表皮生长因子受体(EGFR)抑制剂C225对宫内感染仔鼠脑组织炎症的影响.方法 应用脂多糖(LPS)感染孕鼠建立宫内感染孕鼠模型,给予EGFR抑制剂C225干预,应用免疫组织化学法检测仔鼠脑组织OX42及磷酸化EGFR表达水平的变化,应用酶联免疫吸附测定法(ELISA)检测小胶质细胞活化产物肿瘤坏死因子-α(TNF-α)及白细胞介素-1β (IL-1β)的表达水平.结果 与对照组相比,模型组孕鼠所产仔鼠脑组织OX42及磷酸化EGFR的表达明显增强(P<0.01),且TNF-α及IL-1β含量明显增高(P<0.01);与模型组相比,经C225干预后,LPS诱导小胶质细胞活化不明显,OX42及磷酸化EGFR表达明显低于模型组(P<0.01),TNF-α及IL-1β含量也低于模型组(P<0.01).结论 抑制EGFR通路可明显限制LPS诱导的小胶质细胞的激活,EGFR通路可能在外源性感染引起的小胶质细胞活化过程中起桥梁作用,C225可能在神经损伤修复过程中通过调节小胶质细胞起到重要作用.

  18. Microstructural stability of a nickel-based alloy overlay on a 2.25Cr1Mo steel substrate

    OpenAIRE

    Saghafifar, Hassan

    2011-01-01

    Ni-based superalloy weld overlays are widely used in electricity generating plants to significantly reduce high temperature corrosion problems of ferritic steel components under service conditions. Welding a nickel alloy similar to IN625 onto the outer bore of a 2.25Cr1Mo steel tube enhances its service life as a superheater tube in the highly corrosive environment of a Waste-to-Energy boiler. For the purposes of studying the effects of high temperature service on the microstructure of this l...

  19. Volatility-constrained correlation identifies the directionality of the influence between Japan’s Nikkei 225 and other financial markets

    Science.gov (United States)

    Ochiai, Tomoshiro; Nacher, Jose C.

    2014-01-01

    Recent financial crises have shown the importance of determining the directionality of the influence between financial assets in order to identify the origin of market instabilities. Here, we analyze the correlation between Japan’s Nikkei stock average index (Nikkei 225) and other financial markets by introducing a volatility-constrained correlation metric. The asymmetric feature of the metric reveals which asset is more influential than the other. As a result, this method allows us to unveil the directionality of the correlation effect, which could not be observed from the standard correlation analysis. Furthermore, we present a theoretical model that reproduces the results observed in empirical analysis.

  20. Guidance and considerations for the implementation of INFCIRC/225/Rev.4, the physical protection of nuclear material and nuclear facilities

    International Nuclear Information System (INIS)

    This publication is intended to provide guidance and considerations for a State's competent authority to better understand and prescribe appropriate requirements, consistent with INFCIRC/225/Rev.4 for the protection of nuclear material and nuclear facilities which are compatible with accepted international practice. This report, together with a more detailed report, Handbook on the Physical Protection of Nuclear Material and Facilities, which addresses to the licensee or designer of physical protection systems who has specific implementation and compliance responsibilities, should be used in conjunction to each other to provide better and comprehensive guidance on physical protection

  1. Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Revision 5). Recommendations (Spanish Edition)

    International Nuclear Information System (INIS)

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  2. Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Revision 5): Recommendations

    International Nuclear Information System (INIS)

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  3. Nuclear Security Recommendations on Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225/Revision 5). Recommendations (Arabic Edition)

    International Nuclear Information System (INIS)

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  4. Nuclear security recommendations on physical protection of nuclear material and nuclear facilities (INFCIRC/225/Revision 5). Recommendations (Chinese Edition)

    International Nuclear Information System (INIS)

    This publication, Revision 5 of Physical Protection of Nuclear Material and Nuclear Facilities (INFCIRC/225), is intended to provide guidance to States and their competent authorities on how to develop or enhance, implement and maintain a physical protection regime for nuclear material and nuclear facilities, through the establishment or improvement of their capabilities to implement legislative and regulatory programmes. The recommendations presented in this publication reflect a broad consensus among IAEA Member States on the requirements which should be met for the physical protection of nuclear materials and nuclear facilities.

  5. Therapeutic efficacy and toxicity of {sup 225}Ac-labelled vs. {sup 213}Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Essler, Markus; Gaertner, Florian C.; Blechert, Birgit; Senekowitsch-Schmidtke, Reingard; Seidl, Christof [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Neff, Frauke [Helmholtz Zentrum Muenchen, Institute of Pathology, Neuherberg (Germany); Bruchertseifer, Frank; Morgenstern, Alfred [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany)

    2012-04-15

    Targeted delivery of alpha-particle-emitting radionuclides is a promising novel option in cancer therapy. We generated stable conjugates of the vascular tumour-homing peptide F3 both with {sup 225}Ac and {sup 213}Bi that specifically bind to nucleolin on the surface of proliferating tumour cells. The aim of our study was to determine the therapeutic efficacy of {sup 225}Ac-DOTA-F3 in comparison with that of {sup 213}Bi-DTPA-F3. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were determined via clonogenic assays. The therapeutic efficacy of both constructs was assayed by repeated treatment of mice bearing intraperitoneal MDA-MB-435 xenograft tumours. Therapy was monitored by bioluminescence imaging. Nephrotoxic effects were analysed by histology. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were 53 kBq/ml and 67 Bq/ml, respectively. The median survival of control mice treated with phosphate-buffered saline was 60 days after intraperitoneal inoculation of 1 x 10{sup 7} MDA-MB-435 cells. Therapy with 6 x 1.85 kBq of {sup 225}Ac-DOTA-F3 or 6 x 1.85 MBq of {sup 213}Bi-DTPA-F3 prolonged median survival to 95 days and 97 days, respectively. While F3 labelled with short-lived {sup 213}Bi (t{sub 1/2} 46 min) reduced the tumour mass at early time-points up to 30 days after treatment, the antitumour effect of {sup 225}Ac-DOTA-F3 (t{sub 1/2} 10 days) increased at later time-points. The difference in the fraction of necrotic cells after treatment with {sup 225}Ac-DOTA-F3 (43%) and with {sup 213}Bi-DTPA-F3 (36%) was not significant. Though histological analysis of kidney samples revealed acute tubular necrosis and tubular oedema in 10-30% of animals after treatment with {sup 225}Ac-DOTA-F3 or {sup 213}Bi-DTPA-F3, protein casts were negligible (2%), indicating only minor damage to the kidney. Therapy with both {sup 225}Ac-DOTA-F3 and {sup 213}Bi-DTPA-F3 increased survival of mice with peritoneal carcinomatosis. Mild renal toxicity of both

  6. Development of Cr{sub 3}C{sub 2}-25(Ni20Cr) nanostructured coatings; Desenvolvimento de revestimentos nanostruturados de Cr{sub 3}C{sub 2}-25(Ni20Cr)

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Cecilio Alvares da

    2012-07-01

    This study is divided in two parts. The first part is about the preparation of nanostructured Cr{sub 3}C{sub 2}-25(Ni20Cr) powders by high energy milling followed by characterization of the milled and the as received powder. Analyses of some of the data obtained were done using a theoretical approach. The second part of this study is about the preparation and characterization of coatings prepared with the nanostructured as well as the as received Cr{sub 3}C{sub 2}-25(Ni20Cr) powders. The high temperature erosion-oxidation (E-O) behavior of the coatings prepared with the two types of powders has been compared based on a technological approach. The average crystallite size of the Cr{sub 3}C{sub 2}-25(Ni20Cr) powder decreased rapidly from 145 nm to 50 nm in the initial stages of milling and thereafter decreased slowly to a steady state value of around 10 nm with further increase in milling time. This steady state corresponds to the beginning of a dynamic recovery process. The maximum lattice strain ({epsilon} = 1,17%) was observed in powders milled for 16 hours, and this powders critical crystallite size was 28 nm. In contrast, the lattice parameter attained a minimum for powders milled for 16 hours. Upon reaching the critical crystallite size, the dislocation density attained a steady state regime and all plastic deformation introduced in the material there after was in the form of events occurring at the grain boundaries, due mainly to grain boundary sliding. The deformation energy stored in the crystal lattice of the Cr{sub 3}C{sub 2}-25(Ni20Cr) powders milled for different times was determined from enthalpy variation measurements. These results indicated that the maximum enthalpy variation ({delta}H = 722 mcal) also occurred for powders milled for 16 hours. In a similar manner, the maximum specific heat variation ({delta}C{sub p} = 0,278 cal/gK) occurred for powders milled for 16 hours. The following mechanical properties of Cr{sub 3}C{sub 2}-25(Ni20Cr) coatings

  7. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia.

    Science.gov (United States)

    Irvine, David A; Zhang, Bin; Kinstrie, Ross; Tarafdar, Anuradha; Morrison, Heather; Campbell, Victoria L; Moka, Hothri A; Ho, Yinwei; Nixon, Colin; Manley, Paul W; Wheadon, Helen; Goodlad, John R; Holyoake, Tessa L; Bhatia, Ravi; Copland, Mhairi

    2016-01-01

    Targeting the Hedgehog (Hh) pathway represents a potential leukaemia stem cell (LSC)-directed therapy which may compliment tyrosine kinase inhibitors (TKIs) to eradicate LSC in chronic phase (CP) chronic myeloid leukaemia (CML). We set out to elucidate the role of Hh signaling in CP-CML and determine if inhibition of Hh signaling, through inhibition of smoothened (SMO), was an effective strategy to target CP-CML LSC. Assessment of Hh pathway gene and protein expression demonstrated that the Hh pathway is activated in CD34(+) CP-CML stem/progenitor cells. LDE225 (Sonidegib), a small molecule, clinically investigated SMO inhibitor, used alone and in combination with nilotinib, inhibited the Hh pathway in CD34(+) CP-CML cells, reducing the number and self-renewal capacity of CML LSC in vitro. The combination had no effect on normal haemopoietic stem cells. When combined, LDE225 + nilotinib reduced CD34(+) CP-CML cell engraftment in NSG mice and, upon administration to EGFP(+) /SCLtTA/TRE-BCR-ABL mice, the combination enhanced survival with reduced leukaemia development in secondary transplant recipients. In conclusion, the Hh pathway is deregulated in CML stem and progenitor cells. We identify Hh pathway inhibition, in combination with nilotinib, as a potentially effective therapeutic strategy to improve responses in CP-CML by targeting both stem and progenitor cells. PMID:27157927

  8. Research of stress corrosion cracking of T225NG titanium alloy in loop water of high temperature and high pressure

    Institute of Scientific and Technical Information of China (English)

    Xu Jijin; Yan Keng; Chen Ligong; Jiang Chengyu

    2006-01-01

    Double cantilever beam (DCB) specimens were used to research the stress corrosion cracking of T225NG titanium alloy in loop water of high temperature and high pressure. DCB specimens were forced pre-stress, put into high pressure autoclave, and the stress corrosion and crack expansion of specimens were observed and measured in 500 h, 1 000 h and 2 000h respectively. The results show that small expansion occurred along the direction of pre-cracking. According to calculation,the speed of cracking expansion is lower than 10 -9 m/s in 500 h and the value of KIscc/KI is higher than 0. 75, which proves that T225NG has an excellent corrosion resistance in loop water. The main reason is that there is an oxide film on the surface of specimens. According to the analysis of energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD), the oxide film consists of TiO2. Therefore, the oxide film at the crack tip impedes the hydrogen separating out from the cathode to penetrate into titanium alloy and resists hydrogen embrittlement.

  9. Lattice rotation and stability of 22.5 deg. ND rotated cube orientation in cold rolled polycrystalline AA 5182 aluminum alloy

    International Nuclear Information System (INIS)

    AA 5182 aluminum alloy with a strong cube texture was cold rolled to different reductions at an angle of 22.5 deg. to the prior rolling direction. The texture evolution at this new rolling direction was investigated by X-ray diffraction. The rotation paths and stability of the 22.5 deg. ND rotated cube orientation were determined based on the variation in the three-dimensional orientation distribution function (ODF) with rolling reduction. The results show that most of the grains with the 22.5 deg. ND rotated cube orientation are directly rotated to the β fiber along different rotation paths, but there are a few grains moving through the cube orientation to the β fiber. The {0 0 1} oriented grains possess the lowest stability during rolling, and the stability increases as the initial orientation changes from the {0 0 1} orientation to the {0 0 1} orientation along the φ1 axis

  10. Epidermal growth factor receptors as a target for cancer treatment: the emerging role of IMC-C225 in the treatment of lung and head and neck cancers.

    Science.gov (United States)

    Herbst, Roy S; Langer, Corey J

    2002-02-01

    Epidermal growth factor receptor is one of four receptors critical to cellular proliferation, differentiation, and survival, and is widely expressed in malignant tissue, particularly in squamous cell carcinoma of the head and neck. Expression has been associated with malignant progression, inhibition of apoptosis, neoplastic angiogenesis, enhanced metastatic potential, and both chemoresistance and radioresistance. IMC-C225 is a chimeric monoclonal antibody that targets extracellular epidermal growth factor receptor; it has shown both in vitro and in vivo antitumor activity in tumor cells lines expressing epidermal growth factor receptor, including heightened radiation response in vitro in cultured human squamous cell carcinoma and enhancement of taxane- and platinum-induced cytotoxicity in non-small cell lung cancer xenografts. In A431 head and neck squamous cell xenografts, IMC-C225 administered both before and after radiation therapy yields a radiation enhancement factor of 3.62, attributable to both tumor necrosis and antiangiogenesis. In phase I pharmacokinetic studies, IMC-C225 has a long half-life, lending itself to convenient weekly administration. It has shown a favorable toxicity profile, limited primarily to allergic and dermatologic reactions, the latter characterized by a self-limited, sterile, acneiform rash. Anaphylaxis is rare. Standard treatment entails a loading dose of 400 mg/m(2) at week 1, followed by a maintenance dose of 250 mg/m(2) weekly. An ongoing phase III international multicenter, randomized study in locally advanced squamous cell carcinoma of the head and neck is evaluating therapeutic radiation therapy, either alone or in conjunction with IMC-C225. In a pilot trial, six of nine patients with platinum-exposed squamous cell carcinoma of the head and neck exhibited objective response. In an ongoing phase II trial in patients with stable or progressive disease on platinum-based therapy, the preliminary response rate is approximately 20

  11. Fabrication of bulk glassy Zr41Ti14Ni8Cu12.5Be22.5Fe2 alloy by water quenching

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A glassy Zr41Ti14Ni8Cu12.5Be22.5Fe2 rod with a diameter of 9 mm was successfully produced by water quenching.The effects of iron addition on thermal stability and hardness of Zr41Ti14Ni8Cu12.5Be22.5Fe2 bulk amorphous alloy were investigated by XR D,DSC and microhardness test.It is found that the full annealing would enhance the strength of the alloy significantly.The cause of the increase in hardness was analyzed and the formation mechanisms of the bulk amorphous alloy are discussed.

  12. Cyclic and isothermal oxidation behavior of 2.25Cr-1Mo steel; Estudio del comportamiento del acero 2.25Cr-1Mo frente a los fenomenos de oxidacion ciclica e isoterma

    Energy Technology Data Exchange (ETDEWEB)

    Proy, M.; Utrilla, M. v.; Otero, E.

    2014-04-01

    Cyclic and isothermal oxidation of chromium-molybdenum steel 2.25Cr-1Mo were analyzed at 550 degree centigrade and 650 degree centigrade during 360 hours in air atmospheres. The cycles were performed with two stages; one of heating in furnace during 90 minutes and then the sample were cooled to 50 degree centigrade by air flow. Thermogravimetric analyses were performed to obtain high temperature corrosion kinetics. Several characterization techniques have been used to identify the corrosion mechanism, as X-Ray Diffraction (XRD), Optical Microscopy (OM) and Scanning Electron Microscopy (SEM). Thermal cycling tests can changes the corrosion mechanism, due cracks propagation in oxide scale, that witch can favors the access of oxidant agent to the substrate. (Author)

  13. Curative effect observation on 225 case of self-simulation Chaihushuganlidan therapeutic treatment on cholecystitis%自拟柴胡疏肝利胆汤治疗胆囊炎225例疗效观察

    Institute of Scientific and Technical Information of China (English)

    张成军; 朱琳; 刘玉芳

    2012-01-01

    目的观察柴胡疏肝利胆汤治疗胆囊炎的疗效.方法将符合条件的450例患者随机分为治疗组和对照组各225例,治疗组服用柴胡疏肝利胆汤,对照组采用西医常规治疗,两组均治疗3个疗程(7天为1个疗程)后观察疗效.结果两组患者均获不同程度的疗效,但治疗组的疗效明显优于对照组(P<0.05),差异有统计学意义.结论柴胡疏肝利胆汤具有疏肝利胆、行气止痛、化湿清热、利胆排石的功效,且无副作用,便于推广.%Purpose: observation the curative effect of Chaihushuganlidan therapeutic treatment on cholecystitis. Method: random distribution 450 standard patients into two groups with respectively with 225 cases as curative group and control group. The curative group is offered with chaihushudanlidan therapeutic, while the control group is offered with western medical curative treatment. Those two groups both have three courses of treatment (one course of treatment has seven days), then the observation could begin. Result: both two groups of patients get the curative effect with different extent, however, the curative effect of curative group is better than that of control group(p<0.05), that difference has significance of statistics. Conclusion: Chaihushuganlidan therapeutic has the effect of shuganlidan, work qi and remove the pain, disappear the dampness and hotness, benefit the gallbladder and remove the gallstone, with no side effect and convenient to expand.

  14. Fabrication of a Hydroprocessing Reaction Applying 2.25Cr-1Mo-V-Cb-Ca Steel%采用2.25Cr-1Mo-V-Cb-Ca钢的加氢反应器的制造

    Institute of Scientific and Technical Information of China (English)

    张良成; 徐利柏

    2003-01-01

    2.25Cr-1Mo-V-Cb-Ca和3Cr-1Mo-V-Cb-Ca钢已经作为高温高压加氢反应器的材料被发展起来了,这些Cr-Mo-V-Cb-Ca钢由于加了V在高温下有着很高的强度,同时附加的大约o.25%的V还能显著提高高温下抗氢蚀和抗氢脆的能力,附加的Ca也是这种材料独有的特征,它能有效降低焊件热影响区产生再热裂纹的可能性,另外通过附加的V还能减少焊件再热裂纹的灵敏度.虽然采用3Cr-1Mo-V-Cb-Ca钢的加氢反应器已经制造成功了,但本文讨论的是第一次采用2.25Cr-1Mo-V-Cb-Ca钢来制造加氢反应器,而且和ASME规范实例2098比较,我们还取得了这种材料的大量的性能数据.另外,对于传统的探伤技术,我们引荐了一种飞行时间衍射(Time-of-Flight Diffraction)(TOFD)技术来对焊件进行超声波探伤,进一步保证了检测手段的可靠性.

  15. Intergranular Cracking Susceptibility of 2.25Cr Heat-Resistant Steels Depending on Alloying Elements and Impurities

    Science.gov (United States)

    Sung, Hyun Je; Heo, Nam Hoe; Kim, Sung-Joon

    2016-05-01

    The intergranular cracking susceptibility of 2.25Cr heat-resistant steels increases with increasing bulk phosphorus content. This is due to the increase in phosphorus segregation concentration of prior austenite grain boundaries (PAGBs) and the prior austenite grain boundary/carbide interfaces (GCIs) with increasing bulk phosphorus content. Moreover, the susceptibility is higher in tungsten-added steels than the molybdenum-added steel. This is attributed to the higher driving force for carbide formation of tungsten which causes more active carbide formation in the tungsten-added steel, the consequent absence of the repulsive segregation between carbon and phosphorus, and the final higher phosphorus segregation concentration at the PAGBs and the GCIs. Additionally, the absence of sulfur segregation at the PAGBs and the GCIs of the molybdenum-added steel, which arises from the repulsive segregation between carbon and sulfur, acts as an additional factor which lowers the intergranular cracking susceptibility.

  16. Multiconfiguration Dirac-Hartree-Fock calculations of atomic electric dipole moments of 225^Ra, 199^Hg, and 171^Yb

    CERN Document Server

    Radziute, Laima; Jonsson, Per; Biero, Jacek

    2013-01-01

    The multiconfiguration Dirac-Hartree-Fock (MCDHF) method has been employed to calculate atomic electric dipole moments (EDM) of 225^Ra, 199^Hg, and 171^Yb. For the calculations of the matrix elements we extended the relativistic atomic structure package GRASP2K. The extension includes programs to evaluate matrix elements of (P, T)-odd e-N tensor-pseudotensor and pseudoscalar-scalar interactions, the atomic electric dipole interaction, the nuclear Schiff moment, and the interaction of the electron electric dipole moment with nuclear magnetic moments. The interelectronic interactions were accounted for through valence and core-valence electron correlation effects. The electron shell relaxation was included with separately optimised wave functions of opposite parities.

  17. Evaluation of Ceria-Added Cr3C2-25(NiCr) Coating on Three Superalloys under Simulated Incinerator Environment

    Science.gov (United States)

    Mudgal, Deepa; Singh, Surendra; Prakash, Satya

    2015-02-01

    Cr3C2-25(NiCr) coating is widely used in wear, erosion and corrosion applications. In the present study, D-gun-sprayed Cr3C2-25(NiCr) coatings with and without 0.4 wt.% ceria incorporated were deposited on Superni 718, Superni 600 and Superco 605 substrates. Hot-corrosion runs were conducted in 40 %Na2SO4-40 %K2SO4-10 %NaCl-10 %KCl environment at 900 °C for 100 cycles. Corrosion kinetics was monitored using weight gain measurements. Characterization of corrosion products was carried out by field-emission scanning electron microscopy (FESEM)/energy-dispersive spectroscopy (EDS) and x-ray diffraction (XRD) techniques. It was observed that Cr3C2-25(NiCr) coating with and without added ceria deposited on both of the Ni-based alloys showed resistance to corrosion under the given environment. Addition of ceria enhanced the adherence of the oxide to the coating during the corrosion run and reduced the overall weight gain. However, Cr3C2-25(NiCr)-coated Superco 605 did not perform satisfactorily under this environment.

  18. Structures of bulk amorphous Zr41Ti14Ni10Cu12.5Be22.5 alloy in amorphous, crystalline, supercooled liquid and liquid states

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The amorphous and crystal structures of Zr41Ti14Ni10Cu12.5Be22.5 alloy have been analyzed with X-ray diffractometer. The structures of bulk amorphous Zr41Ti14Ni10Cu12.5B22.5 alloy in solid, supercooled liquid and liquid states are almost of the same structure. The RDFs (Radius Distribution Function), the first coordination number, the first coordination radius, the correlation radius and atom number of the cluster were calculated for bulk amorphous Zr41Ti14Ni10Cu12.5B22.5 alloy in different states. The first coordination sphere radii and the first coordination numbers are 0.312nm, 11.2 in solid state, 0.301nm, 10.932 in supercooled liquid region and 0.305nm, 11.296 in liquid state. The crystal structure of Zr41Ti14Ni10Cu12.5B22.5 alloy is consisted of several intermetallic compounds which are CuZr2, Be2Zr, etc. The reason of formation glass for this alloy is that there is a larger resistance for atoms to rearrange and form intermetallic compounds in a long range order.

  19. Prospective clinical phase II study of two new indwelling voice prostheses (Provox Vega 22.5 and 20 Fr) and a novel anterograde insertion device (Provox Smart Inserter)

    NARCIS (Netherlands)

    F.J.M. Hilgers; A.H. Ackerstaff; I. Jacobi; A.J.M. Balm; I.B. Tan; M.W.M. van den Brekel

    2010-01-01

    Objectives/Hypothesis: To assess device life of the new Provox Vega 22.5 and 20 Fr prostheses, to establish whether the optimized airflow characteristics of these devices materialize in better voice characteristics in comparison to Provox2, and to assess the feasibility of voice prosthesis replaceme

  20. 225名育龄妇女孕前、孕中及产后微量元素调查%Survey on Microelements of Pre - pregnancy, Pregnancy and Postpartum Periods Among 225 Childbearing Age Women

    Institute of Scientific and Technical Information of China (English)

    王建辉

    2011-01-01

    Objective To investigate the levels and influencing factors of the microelements in pre- pregnancy, pregnancy, and postpartum periods among the childbearing age women, and to offer the scientific evidence for the health care of childbearing age women. Methods We collected the blood samples of 225 childbearing age women who received the examination during the pre- pregnancy, pregnancy, and postpartum periods in the Maternal and Child Health Hospital of Hunan Province from January 2009 to May 2011. Atomic absorption spectrometer was used to detect the contents of Ca, Mg, Fe, Zn, and Cu in serum. Results The levels of Ca, Mg, Fe, Zn, and Cu showed a skewed distribution in different periods. The deficiency of Fe was common in the pregnancy and postpartum periods (P<0.05); and moreover, the levels of Zn and Ca were generally lower in the pregnancy and postpartum periods (P<0.05). Conclusions The levels of the microelements in the pregnancy and postpartum periods are lower, which suggest that it has significance to the growth of fetus and the recovery of puerpera through scientific intake of the nutrition and necessary microelements according to the eating habits and strengthening the physical exercises.%目的 了解育龄妇女在孕前、孕中及产后微量元素水平变化及影响因素,为育龄妇女营养保健提供科学依据.方法 连续收集2009年1月- 2011年5月在本院孕前、孕中检查及产后体检的225例育龄妇女血样,用原子吸收光谱分析仪检测Ca、Mg、Fe、Zn、Cu的含量.结果 不同时期妇女全血中Ca、Mg、Fe、Zn、Cu含量呈偏态分布,孕期及产后铁缺乏常见(P<0.05).另外,孕期和产后妇女锌、钙也总体偏低(P<0.05).结论 孕期及产后妇女微量元素营养状况处在一个较低的水平,提示应注意合理营养摄人,根据饮食习惯科学补充必需的微量元素,适当加强锻炼,对体内胎儿发育及自身恢复都有一定的意义.

  1. Gain-of-function R225W mutation in human AMPKgamma(3 causing increased glycogen and decreased triglyceride in skeletal muscle.

    Directory of Open Access Journals (Sweden)

    Sheila R Costford

    Full Text Available BACKGROUND: AMP-activated protein kinase (AMPK is a heterotrimeric enzyme that is evolutionarily conserved from yeast to mammals and functions to maintain cellular and whole body energy homeostasis. Studies in experimental animals demonstrate that activation of AMPK in skeletal muscle protects against insulin resistance, type 2 diabetes and obesity. The regulatory gamma(3 subunit of AMPK is expressed exclusively in skeletal muscle; however, its importance in controlling overall AMPK activity is unknown. While evidence is emerging that gamma subunit mutations interfere specifically with AMP activation, there remains some controversy regarding the impact of gamma subunit mutations. Here we report the first gain-of-function mutation in the muscle-specific regulatory gamma(3 subunit in humans. METHODS AND FINDINGS: We sequenced the exons and splice junctions of the AMPK gamma(3 gene (PRKAG3 in 761 obese and 759 lean individuals, identifying 87 sequence variants including a novel R225W mutation in subjects from two unrelated families. The gamma(3 R225W mutation is homologous in location to the gamma(2R302Q mutation in patients with Wolf-Parkinson-White syndrome and to the gamma(3R225Q mutation originally linked to an increase in muscle glycogen content in purebred Hampshire Rendement Napole (RN- pigs. We demonstrate in differentiated muscle satellite cells obtained from the vastus lateralis of R225W carriers that the mutation is associated with an approximate doubling of both basal and AMP-activated AMPK activities. Moreover, subjects bearing the R225W mutation exhibit a approximately 90% increase of skeletal muscle glycogen content and a approximately 30% decrease in intramuscular triglyceride (IMTG. CONCLUSIONS: We have identified for the first time a mutation in the skeletal muscle-specific regulatory gamma(3 subunit of AMPK in humans. The gamma(3R225W mutation has significant functional effects as demonstrated by increases in basal and AMP

  2. Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution

    International Nuclear Information System (INIS)

    The R. prowazekii 3-ketoacyl-(acyl-carrier-protein) reductase is similar to those from other prokaryotic pathogens but differs significantly from the mammalian orthologue, strengthening its case as a potential drug target. Rickettsia prowazekii, a parasitic Gram-negative bacterium, is in the second-highest biodefense category of pathogens of the National Institute of Allergy and Infectious Diseases, but only a handful of structures have been deposited in the PDB for this bacterium; to date, all of these have been solved by the SSGCID. Owing to its small genome (about 800 protein-coding genes), it relies on the host for many basic biosynthetic processes, hindering the identification of potential antipathogenic drug targets. However, like many bacteria and plants, its metabolism does depend upon the type II fatty-acid synthesis (FAS) pathway for lipogenesis, whereas the predominant form of fatty-acid biosynthesis in humans is via the type I pathway. Here, the structure of the third enzyme in the FAS pathway, 3-ketoacyl-(acyl-carrier-protein) reductase, is reported at a resolution of 2.25 Å. Its fold is highly similar to those of the existing structures from some well characterized pathogens, such as Mycobacterium tuberculosis and Burkholderia pseudomallei, but differs significantly from the analogous mammalian structure. Hence, drugs known to target the enzymes of pathogenic bacteria may serve as potential leads against Rickettsia, which is responsible for spotted fever and typhus and is found throughout the world

  3. Carbide evolution and service life of simulated post weld heat treated 2.25Cr–1Mo steel

    International Nuclear Information System (INIS)

    To estimate the service life of the reactor internals made of 2.25Cr–1Mo steel in the high temperature gas-cooled reactor pebble-bed module demonstration plant, creep rupture test was performed on the simulated post weld heat treated steel at 773 K over a range of stress levels 300–200 MPa. It has been shown that the rupture time is 126–5532 h, correspondingly. Then, the service life under stress of 161.2 MPa at 648 K was calculated to be so long as 210,374,853 h (≈24,015 years). Four types of carbides M3C, M2C, M7C3 and M23C6 existed in both the steel plate and the post-rupture specimens. As the rupture time increases, the weight percentages of M23C6 and M2C that are stable in thermodynamics in the post-rupture specimens increase while those of metastable M3C and M7C3 decrease on the whole. During the long term creep exposure, the deformation promotes the precipitation of M3C, M2C and M23C6, according to the experimental results with the deformed and undeformed parts of the post-rupture specimens, but its influence on the weight percentage of M7C3 seems rather complicated

  4. Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5

    Energy Technology Data Exchange (ETDEWEB)

    Brown, J.A.; He, X.F.; Westerheide, S.D. [Emory Univ. School of Medicine, Atlanta, GA (United States)] [and others

    1996-06-01

    Class II major histocompatibility complex (MHC) genes are regulated in a coordinate manner. A set of conserved upstream elements termed the W/Z/S, X1, X2, and Y boxes are found 5{prime} to class II genes, the R gene, and the HLA-DM genes. These conserved elements are required for tissue-specific and IFN{gamma}-mediated regulation of these genes. The DNA-binding proteins RFX, X2BP, and NFY have been found to specifically interact with the X1, X2, and Y box elements, respectively, as well as with each other. A role for an additional factor was recently demonstrated by the cloning of a gene that could complement the MHC class H gene-specific transcriptional deficiency in the mutant cell line RJ2.2.5 as well as cell lines isolated from patients exhibiting the bare lymphocyte syndrome. This gene was termed the class II transactivator or CIITA. While both genetic and biochemical studies have indicated interactions between the DNA-binding proteins described above, direct interactions with CIITA have not been described. 23 refs., 3 figs.

  5. Laser-trapping of {sup 225}Ra and {sup 226}Ra with repumping by room-temperature blackbody radiation.

    Energy Technology Data Exchange (ETDEWEB)

    Guest, J. R.; Scielzo, N. D.; Ahmad, I.; Bailey, K.; Greene, J. P.; Holt, R. J.; Lu, Z.-T.; O' Connor, T. P.; Potterveld, D. H.; Physics; Enrico Fermi Inst.; Univ. of Chicago

    2007-02-27

    We have demonstrated Zeeman slowing and capture of neutral {sup 225}Ra and {sup 226}Ra atoms in a magneto-optical trap. The intercombination transition {sup 1}S{sub 0} {yields} {sup 3}P{sub 1} is the only quasicycling transition in radium and was used for laser-cooling and trapping. Repumping along the {sup 3}D{sub 1} {yields} {sup 1}P{sub 1} transition extended the lifetime of the trap from milliseconds to seconds. Room-temperature blackbody radiation was demonstrated to provide repumping from the metastable {sup 3}P{sub 0} level. We measured the isotope shift and hyperfine splittings on the {sup 3}D{sub 1} {yields} {sup 1}P{sub 1} transition with the laser-cooled atoms, and set a limit on the lifetime of the {sup 3}D{sub 1} level based on the measured blackbody repumping rate. Laser-cooled and trapped radium is an attractive system for studying fundamental symmetries.

  6. The Vimos VLT Deep Survey: Global properties of 20000 galaxies in the I_AB<=22.5 WIDE survey

    CERN Document Server

    Garilli, B; Guzzo, L; MacCagni, D; Le Brun, V; De la Torre, S; Meneux, B; Tresse, L; Franzetti, P; Zamorani, G; Zanichelli, A; Gregorini, L; Vergani, D; Bottini, D; Scaramella, R; Scodeggio, M; Vettolani, G; Adami, C; Arnouts, S; Bardelli, S; Bolzonella, M; Cappi, A; Charlot, S; Ciliegi, P; Contini, T; Foucaud, S; Gavignaud, I; Ilbert, O; Iovino, A; Lamareille, F; McCracken, H J; Marano, B; Marinoni, C; Mazure, A; Merighi, R; Paltani, S; Pellò, R; Pollo, A; Pozzetti, L; Radovich, M; Zucca, E; Blaizot, J; Bongiorno, A; Cucciati, O; Mellier, Y; Moreau, C; Paioro, L

    2008-01-01

    The VVDS-Wide survey has been designed with the general aim of tracing the large-scale distribution of galaxies at z~1 on comoving scales reaching ~100Mpc/h, while providing a good control of cosmic variance over areas as large as a few square degrees. This is achieved by measuring redshifts with VIMOS at the ESO VLT to a limiting magnitude I_AB=22.5, targeting four independent fields with size up to 4 sq.deg. each. The whole survey covers 8.6 sq.deg., here we present the general properties of the current redshift sample. This includes 32734 spectra in the four regions (19977 galaxies, 304 type I AGNs, and 9913 stars), covering a total area of 6.1 sq.deg, with a sampling rate of 22 to 24%. The redshift success rate is above 90% independently of magnitude. It is the currently largest area coverage among redshift surveys reaching z~1. We give the mean N(z) distribution averaged over 6.1 sq.deg. Comparing galaxy densities from the four fields shows that in a redshift bin Deltaz=0.1 at z~1 one still has factor-of...

  7. Dense core properties in the Infrared Dark cloud G14.225-0.506 revealed by ALMA

    CERN Document Server

    Ohashi, Satoshi; Chen, Huei-Ru Vivien; Zhang, Qizhou; Busquet, Gemma; Nakamura, Fumitaka; Palau, Aina; Tatematsu, Ken'ichi

    2016-01-01

    We have performed a dense core survey toward the Infrared Dark Cloud G14.225-0.506 at 3 mm continuum emission with the Atacama Large Millimeter/Submillimeter Array (ALMA). This survey covers the two hub-filament systems with an angular resolution of $\\sim3$\\arcsec ($\\sim0.03$ pc). We identified 48 dense cores. Twenty out of the 48 cores are protostellar due to their association with young stellar objects (YSOs) and/or X-ray point-sources, while the other 28 cores are likely prestellar and unrelated with known IR or X-ray emission. Using APEX 870 $\\mu$m continuum emission, we also identified the 18 clumps hosting these cores. Through virial analysis using the ALMA N$_2$H$^+$ and VLA/Effelsberg NH$_3$ molecular line data, we found a decreasing trend in the virial parameter with decreasing scales from filaments to clumps, and then to cores. The virial parameters of $0.1-1.3$ in cores, indicate that cores are likely undergoing dynamical collapse. The cumulative Core Mass Function (CMF) for the prestellar cores ca...

  8. Unveiling a network of parallel filaments in the Infrared Dark Cloud G14.225-0.506

    CERN Document Server

    Busquet, Gemma; Palau, Aina; Liu, Hauyu Baobab; Sánchez-Monge, Álvaro; Estalella, Robert; Ho, Paul T P; de Gregorio-Monsalvo, Itziar; Pillai, Thushara; Wyrowski, Friedrich; Girart, Josep M; Santos, Fábio P; Franco, Gabriel A P

    2012-01-01

    We present the results of combined NH3(1,1) and (2,2) line emission observed with the Very Large Array and the Effelsberg 100m telescope of the Infrared Dark Cloud G14.225-0.506. The NH3 emission reveals a network of filaments constituting two hub-filament systems. Hubs are associated with gas of rotational temperature Trot \\sim 25 K, non-thermal velocity dispersion ~1.1 km/s, and exhibit signs of star formation, while filaments appear to be more quiescent (Trot \\sim 11 K, non-thermal velocity dispersion ~0.6 km/s). Filaments are parallel in projection and distributed mainly along two directions, at PA \\sim 10 deg and 60 deg, and appear to be coherent in velocity. The averaged projected separation between adjacent filaments is between 0.5 pc and 1pc, and the mean width of filaments is 0.12 pc. Cores within filaments are separated by ~0.33 pc, which is consistent with the predicted fragmentation of an isothermal gas cylinder due to the 'sausage'-type instability. The network of parallel filaments observed in G...

  9. Critical level of intergranular fracture to affect the toughness of embrittled 2.25Cr-1Mo steels

    Science.gov (United States)

    Islam, M. A.; Knott, J. F.; Bowen, P.

    2004-10-01

    In general, the low-temperature brittle fracture mode of unembrittled ferritic steel is transgranular cleavage. During temper embrittlement, impurity elements, such as sulfur (S), phosphorus (P), antimony (Sb), arsenic (As), and tin (Sn), segregate to prior austenite grain boundaries, which results in a decrease in the grain boundary cohesive strength. As a result, the brittle transgranular cleavage fracture mode changes to intergranular decohesion in association with the decrease in the critical fracture (stress (σ F) as well as the fracture toughness (K). However, the appearance of intergranular facets on the fracture surface does not cause a decrease in the K and σ F values. In this work, quenched and fully tempered 2.25Cr-1Mo steel (in an unembrittled condition that exhibits almost 100% brittle transgranular cleavage fracture) has been embrittled for 24, 96, and 210 h at 520 °C to produce different proportions of intergranular fracture. These unembrittled and embrittled steel specimens were tested to measure K (at -120 and -196 °C) and σ F (at -196 °C). The experimental results and detailed fractographic observations show that the K and σ F values decrease with an increase in the area fraction of intergranular fracture, provided that the area fraction of the intergranular facet on the brittle fracture surface exceeded a certain critical level, approximately 20 22%.

  10. Containerless solidification of Zr41Ti14Cu12.5Ni10Be22.5 glass-forming alloy in drop tube

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Droplets of Zr41Ti14Cu12.5Ni10Be22.5 glass form-ing alloys with different sizes are solidified in a drop tubecontainerless processing. Glass transition behavior, crystal-lization kinetics, and the phase evolution during annealing of the Zr41Ti14Cu12.5Ni10Be22.5 glassy spheres are investigated. The experimental results indicate that the apparent activation energy of the glass transition (Eg = 435.5 kJ/mol), and the activation energy of the main crystallization reaction (Ep1 = 249.6 kJ/mol) are obviously different from those of bulk glass samples prepared by water quenched (Eg = 559.1 kJ/mol and Ep1 =192.5 kJ/mol). The difference is discussed in the view point of the atomic configuration of the liquid state of the metallic glass and nucleation mechanism.

  11. Vacuum Heat Treatment of 2.25Cr1Mo Steel Impellers%2.25Cr1Mo 钢叶轮的真空热处理

    Institute of Scientific and Technical Information of China (English)

    陈炜

    2015-01-01

    Microstructure and mechanical properties of 2.25Cr1Mo steel impellers subjected to vacuum heat treatment were investigated.The results show that the microstructures of the 2.25Cr1Mo steel impellers are chiefly tempered sorbite,and their mechanical properties conform with the design requirements.Furthermore,the surface quality of the impellers is improved.%研究了2.25Cr1Mo 钢叶轮真空热处理后的显微组织和力学性能。结果表明:真空热处理后2.25Cr1Mo 钢叶轮的显微组织主要为回火索氏体,其力学性能可以满足设计要求,叶轮的表面质量更好。

  12. 我国内地49家企业入围ENR2007年度全球国际承包商225

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    8月16日,美国麦格劳·希尔公司(McGraw Hill)在其网站正式发布了2007年度ENR全球最大225家国际承包商排名,我国内地共有49家企业榜上有名,具体排序如下:

  13. High-Temperature Exposure Studies of HVOF-Sprayed Cr3C2-25(NiCr)/(WC-Co) Coating

    Science.gov (United States)

    Singh, Harpreet; Kaur, Manpreet; Prakash, Satya

    2016-08-01

    In this research, development of Cr3C2-25(NiCr) + 25%(WC-Co) composite coating was done and investigated. Cr3C2-25(NiCr) + 25%(WC-Co) composite powder [designated as HP2 powder] was prepared by mechanical mixing of [75Cr3C2-25(NiCr)] and [88WC-12Co] powders in the ratio of 75:25 by weight. The blended powders were used as feedstock to deposit composite coating on ASTM SA213-T22 substrate using High Velocity Oxy-Fuel (HVOF) spray process. High-temperature oxidation/corrosion behavior of the bare and coated boiler steels was investigated at 700 °C for 50 cycles in air, as well as, in Na2SO4-82%Fe2(SO4)3 molten salt environment in the laboratory. Erosion-corrosion behavior was investigated in the actual boiler environment at 700 ± 10 °C under cyclic conditions for 1500 h. The weight-change technique was used to establish the kinetics of oxidation/corrosion/erosion-corrosion. X-ray diffraction, field emission-scanning electron microscopy/energy-dispersive spectroscopy (FE-SEM/EDS), and EDS elemental mapping techniques were used to analyze the exposed samples. The uncoated boiler steel suffered from a catastrophic degradation in the form of intense spalling of the scale in all the environments. The oxidation/corrosion/erosion-corrosion resistance of the HVOF-sprayed HP2 coating was found to be better in comparison with standalone Cr3C2-25(NiCr) coating. A simultaneous formation of protective phases might have contributed the best properties to the coating.

  14. Time history solution program, L225 (TEV126). Volume 2: Supplemental system design and maintenance document. [for airplane dynamic response using frequency response data

    Science.gov (United States)

    Tornallyay, A.; Clemmons, R. E.; Kroll, R. I.

    1979-01-01

    The time history solution program L225 (TEV126) is described. The program calculates the time responses of a linear system by convoluting the impulsive response functions with the time dependent excitation. The convolution is performed as a multiplication in the frequency domain. Fast Fourier transform techniques are used to transform the product back into the time domain to obtain response time histories. The design and structure of the program is presented.

  15. Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-kappaB signaling pathway with the anti-epidermal growth factor antibody IMC-C225.

    Science.gov (United States)

    Sclabas, Guido M; Fujioka, Shuichi; Schmidt, Christian; Fan, Zhen; Evans, Douglas B; Chiao, Paul J

    2003-01-01

    We have previously demonstrated that RelA is constitutively activated in the majority of human pancreatic cancers and plays an important role in tumorigenesis and metastasis. The antiapoptotic gene bcl-xl is a downstream target of RelA, and regulation of bcl-xl transcription is mediated directly by the nuclear factor kappaB (NF-kappaB) binding sites present in the upstream promoter element of the bcl-xl gene. In this study we investigated the effects of inhibition of epidermal growth factor receptor (EGFR) signaling pathway with the anti-EGFR monoclonal antibody IMC-C225 on constitutive NF-kappaB activation and regulation of apoptosis-related genes in human pancreatic cancer cells. We found that activation of EGFR can be blocked with the anti-EGFR antibody IMC-C225 in the human pancreatic cancer cell line MDA Panc-28, leading to a marked decrease in constitutive NF-kappaB DNA binding activity. Our data also suggest that downregulation of NF-kappaB DNA binding activity by IMC-C225 leads to a decrease in bcl-xl and bfl-1 expression. Therefore, targeting the NF-kappaB signaling pathway with an anti-EGFR antibody may be one strategy to restore apoptosis in human pancreatic cancer cells, thereby enhancing the effect of chemotherapy and radiation therapy.

  16. Crystallization in Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass under pressure

    DEFF Research Database (Denmark)

    Jiang, Jianzhong; Zhou, T.J.; Rasmussen, Helge Kildahl;

    2000-01-01

    The effect of pressure on the crystallization behavior of the bulk metallic glass-forming Zr41.2Ti13.8Cu12.5Ni10Be22.5 alloy with a wide supercooled liquid region has been investigated by in situ high-pressure and high-temperature x-ray powder diffraction measurements using synchrotron radiation......)], reporting a decrease of the crystallization temperature under pressure in a pressure range of 0-6 GPa for the bulk glass Zr41Ti14Cu12.5Ni9Be22.5C1 alloy. Compressibility with a volume reduction of approximately 22% at room temperature does not induce crystallization in the Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk...... glass alloy. This indicates that the densification effect induced by pressure in the pressure range investigated plays a minor role in the crystallization behavior of this bulk glass alloy. The different crystallization behavior of the carbon-free and the carbon-containing glassy alloys has been...

  17. Field Test Report: Preliminary Aquifer Test Characterization Results for Well 299-W15-225: Supporting Phase I of the 200-ZP-1 Groundwater Operable Unit Remedial Design

    Energy Technology Data Exchange (ETDEWEB)

    Spane, Frank A.; Newcomer, Darrell R.

    2009-09-23

    This report examines the hydrologic test results for both local vertical profile characterization and large-scale hydrologic tests associated with a new extraction well (well 299-W15-225) that was constructed during FY2009 for inclusion within the future 200-West Area Groundwater Treatment System that is scheduled to go on-line at the end of FY2011. To facilitate the analysis of the large-scale hydrologic test performed at newly constructed extraction well 299-W15-225 (C7017; also referred to as EW-1 in some planning documents), the existing 200-ZP-1 interim pump-and-treat system was completely shut-down ~1 month before the performance of the large-scale hydrologic test. Specifically, this report 1) applies recently developed methods for removing barometric pressure fluctuations from well water-level measurements to enhance the detection of hydrologic test and pump-and-treat system effects at selected monitor wells, 2) analyzes the barometric-corrected well water-level responses for a preliminary determination of large-scale hydraulic properties, and 3) provides an assessment of the vertical distribution of hydraulic conductivity in the vicinity of newly constructed extraction well 299-W15-225. The hydrologic characterization approach presented in this report is expected to have universal application for meeting the characterization needs at other remedial action sites located within unconfined and confined aquifer systems.

  18. 225名健康儿童建立呼出气一氧化氮正常值%Reference values and determinants of fractional exhaled nitric oxide in 225 healthy children in Suzhou

    Institute of Scientific and Technical Information of China (English)

    刘媛媛; 陆燕红; 郝创利

    2012-01-01

    目的 探讨6~14岁儿童呼出气一氧化氮(FeNO)正常值范围及其影响因素.方法 选取苏州市6~14岁在校儿童进行问卷调查及FeNO、肺功能、外周血嗜酸粒细胞(EOS)计数的检测,筛选出健康儿童建立FeNO正常值.FeNO的测定采用电化学法,根据美国胸科学会/欧洲呼吸学会指南进行操作.分析性别、年龄、身高、体重、外周血EOS计数、肺功能和FeNO的相关性.结果 参与调查的450名儿童中符合纳入标准者225名(男生107名,女生118名)进入分析.FeNO值呈偏态分布,经自然对数转换后呈正态分布.FeNO平均值为11 ppb(95%CI:5~28 ppb),最小值9岁儿童FeNO显著高于≤9岁儿童(P=0.002);FeNO与性别、体重、BMI、FEV1/FVC无显著相关性.结论 苏州地区6~14岁儿童FeNO正常参考值为5~28 ppb;FeNO水平与外周血EOS计数、身高、FEV1显著相关.%Objectives The aim of this study was to establish FeNO reference values for healthy school-aged children in Suzhou according to the international guidelines, and to assess the determinants of FeNO. Methods Children aged 6-14 years were recruited from two public schools in Suzhou. The subjects completed a respiratory questionnaire, and were examined with measurements of FeNO, spirometry and blood eosinophil. Healthy children were screened to establish reference values of FeNO. FeNO was measured with a chemiluminescence analyzer according to American Thoracic Society guidelines ( single breath online, exhalation flow 50 mL · s-1 ). The associations between different determinants ( sex, age, height, weight, BMI, peripheral blood EOS count, FEV1/FVC, lung function) and FeNO were analyzed. Results Finally, a total of 450 children participated in the study, and 225 children fulfilled the inclusion criteria of healthy subjects ( 107 boys and 118 girls ). FeNO data were skewed, and met normal distribution after natural logarithm transformation. The geometric mean of FeNO in 225 children was 11 parts per

  19. Comment: 225 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available itute of Agrobiological Sciences), Daiki Horikawa (NASA Ames Research Center) licenced under CC Attribution2....1 Japan ヨコヅナクマムシ 電子顕微鏡写真 撮影:行弘文子(農業生物資源研究所)、堀川大樹(NASA Ames Research Center) bando 2010/02/15 14:55:04 2010/02/16 10:43:01 ...

  20. Case 225: Leiomyoma.

    Science.gov (United States)

    DiPoce, Jason; Liu-Jarin, Xiaolin; Newhouse, Jeffrey

    2016-01-01

    A 33-year-old pregnant woman (gravida 11, para 8) presented with increasing severe abdominal pain during the first trimester of pregnancy and increasing abdominal distention out of proportion to her prior pregnancies. Ultrasonography (US) without Doppler performed at another hospital had revealed a pelvic mass; therefore, this patient had been referred to our institution for further evaluation. Unenhanced magnetic resonance (MR) imaging was then performed at 8 weeks of gestation. The main portion of the gravid uterus and the ovaries was not seen on these images, but the parts that were seen appeared normal. Diagnostic laparoscopic biopsy was performed during the first trimester, but complete removal of the mass was deferred because of fears the pregnancy would be lost. The patient was closely observed throughout the pregnancy with serial US until the 37th week of gestation, at which time the patient underwent Caesarian section. At the time of Caesarian section, the mass was noted to extend from the spleen downward deep into the pelvis. A biopsy was performed at the time of Caesarian section. Definitive removal of the mass was deferred at the time of Caesarian section to minimize postpartum blood loss and to further delineate the mass with imaging for future surgery. Intravenous contrast material-enhanced (120 mL of Omnipaque 350; Nycomed Amersham, Princeton, NJ) computed tomography (CT) was performed 3 days after Caesarian section. The cystic component measured approximately 15 HU. Repeat MR imaging 1.5 months after Caesarian section was then performed. No loss of signal intensity in the mass was seen on fat-saturated images. There was no evidence of local or distant metastatic disease. The mass abutted and displaced the uterus and the ovaries but did not distort either of these organs. Vascular anatomy was not useful in determining the origin of the mass. The comprehensive metabolic panel and complete blood count were normal throughout and after the pregnancy. PMID:26690995

  1. Novel BAC mouse model of Huntington’s disease with 225 CAG repeats exhibits an early widespread and stable degenerative phenotype

    Science.gov (United States)

    Wegrzynowicz, Michal; Bichell, Terry Jo; Soares, Barbara D.; Loth, Meredith K.; McGlothan, Jennifer L.; Alikhan, Fatima S.; Hua, Kegang; Coughlin, Jennifer M.; Holt, Hunter K.; Jetter, Christopher S.; Mori, Susumu; Pomper, Martin G.; Osmand, Alexander P.; Guilarte, Tomás R.; Bowman, Aaron B.

    2015-01-01

    BACKGROUND Unusually large CAG repeat expansions (>60) in exon one of Huntingtin (HTT) are invariably associated with a juvenile-onset form of Huntington’s disease (HD), characterized by a more extensive and rapidly progressing neuropathology than the more prevalent adult-onset form. However, existing mouse models of HD that express the full-length Htt gene with CAG repeat lengths associated with juvenile HD (ranging between ~75 to ~150 repeats in published models) exhibit selective neurodegenerative phenotypes more consistent with adult-onset HD. OBJECTIVE To determine if a very large CAG repeat (>200) in full-length Htt elicits neurodegenerative phenotypes consistent with juvenile HD. METHODS Using a bacterial artificial chromosome (BAC) system, we generated mice expressing full-length mouse Htt with ~225 CAG repeats under control of the mouse Htt promoter. Mice were characterized using behavioral, neuropathological, biochemical and brain imaging methods. RESULTS BAC-225Q mice exhibit phenotypes consistent with a subset of features seen in juvenile-onset HD: very early motor behavior abnormalities, reduced body weight, widespread and progressive increase in Htt aggregates, gliosis, and neurodegeneration. Early striatal pathology was observed, including reactive gliosis and loss of dopamine receptors, prior to detectable volume loss. HD-related blood markers of impaired energy metabolism and systemic inflammation were also increased. Aside from an age-dependent progression of diffuse nuclear aggregates at 6 months of age to abundant neuropil aggregates at 12 months of age, other pathological and motor phenotypes showed little to no progression. CONCLUSIONS The HD phenotypes present in animals 3 to 12 months of age make the BAC-225Q mice a unique and stable model of full-length mutant Htt associated phenotypes, including body weight loss, behavioral impairment and HD-like neurodegenerative phenotypes characteristic of juvenile-onset HD and/or late-stage adult

  2. Compression behavior of Zr41Ti14Cu12.5Ni10Be22.5 bulk metallic glass up to 24 GPa

    Institute of Scientific and Technical Information of China (English)

    LI; Gong; ZHAN; Zaiji; LIU; Jing; YUN; Jinku; SUN; Liling; L

    2005-01-01

    The compression of a Zr41Ti14Cu12.5Ni10Be22.5 bulk metallic glass (BMG) is investigated at room temperature up to 24 GPa using in-situ high pressure energy dispersive X-ray diffraction with a synchrotron radiation source. The pressure-induced structural relaxation is exhibited. It is found that below about 8 GPa, the existence of excess free volume contributes to the rapid structural relaxation, which gives rise to the rapid volumetric change, and the structural relaxation results in the structural stiffness under higher pressure.

  3. The abnormal segregation behavior of solutes under tensile stress and its effect on carbide reactions in 2.25Cr–1.5W heat-resistant steels

    International Nuclear Information System (INIS)

    The phosphorus segregation concentration at grain boundary/carbide interfaces of 2.25Cr–1.5W heat-resistant steels under tensile stress shows a broad convex profile in a log time versus segregation concentration plot. The decrease in phosphorus segregation concentration after the maximum in the convex profile is due to the formation of new equilibrium MC carbides on the surface of the pre-formed M23C6 carbides and its partitioning effect of the phosphorus segregated at the M23C6 carbide interface to the interface of the new MC carbides

  4. Fe2+-Tetracycline-Mediated Cleavage of the Tn10 Tetracycline Efflux Protein TetA Reveals a Substrate Binding Site near Glutamine 225 in Transmembrane Helix 7

    OpenAIRE

    McMurry, Laura M.; Aldema-Ramos, Mila L.; Levy, Stuart B.

    2002-01-01

    TetA specified by Tn10 is a class B member of a group of related bacterial transport proteins of 12 transmembrane alpha helices that mediate resistance to the antibiotic tetracycline. A tetracycline-divalent metal cation complex is expelled from the cell in exchange for a entering proton. The site(s) where tetracycline binds to this export pump is not known. We found that, when chelated to tetracycline, Fe2+ cleaved the backbone of TetA predominantly at a single position, glutamine 225 in tra...

  5. Material test data of 2.25Cr-1Mo Steel and Mod.9Cr-1Mo Steel (Set of data)

    OpenAIRE

    小高 進; 加藤 章一; 吉田 英一; 川上 朋広; 鈴木 高一; 高森 裕二; 川島 成一

    2003-01-01

    Matenal tests of 2.25Cr-1Mo Steel and Mod. 9Cr-1Mo Steel, which were used for structure material of fast breeder reactor (FBR) have been preformed in New Technology Development Group. In this report, the result of test obtained up to this time was collected. Many valuable data from long time test for more than 100000 hours including sodium environment test data in this report will be used for material examination of FBR in the future. It creates, in order for for ASME Code Committee to re...

  6. (INCONSTITUCIONALIDAD DE LA REGLA DE ATRIBUCIÓN PREFERENTE MATERNA DEL CUIDADO PERSONAL DE LOS HIJOS DEL ARTÍCULO 225 DEL CÓDIGO CIVIL CHILENO (Unconstitutionality of the preference towards the mother of the legal attribution of child physical custody of the article 225 section of the chilean civil code

    Directory of Open Access Journals (Sweden)

    Fabiola Lathrop Gómez

    2010-01-01

    Full Text Available El presente artículo sostiene que la norma de atribución preferente materna del cuidado personal de los hijos, contenida en el artículo 225 del Código Civil chileno, es inconstitucional, pues se funda en una discriminación arbitraria, injusta, no razonable y desproporcionada, vulneradora del principio de igualdad jurídica y material. Se analiza el caso chileno a la luz de los Tratados Internacionales de Derechos Humanos y del Derecho Comparado.The present article sustains that the preference towards the mother of the legal attribution of physical custody container] in the article 225 of the Chilean Civil Code, is unconstitutional, since is based in an arbitrary discrimination, unjust, not reasonable and disproportionate, that violates the principie of legal and material equality The Chilean case is analyzed in the light of International Human Rights Treaties and Comparative Law.

  7. 靶向纳米造影剂C225-USPIO标记裸鼠鼻咽癌移植瘤MR成像研究%Studies on MR Imaging of Nude Mice Bearing Nasopharyngeal Carcinoma Xenograft by Using Targeted Nano-Contrast Agent C225-USPIO

    Institute of Scientific and Technical Information of China (English)

    钱莹; 龙国贤; 刘东伯; 胡国清

    2012-01-01

    Objective: This work aimed to design epidermal growth factor receptor-targeted contrast agent C225-USPIO and to evaluate its magnetic resonance imaging (MRI) capability to mark the nasopharyngeal carcinoma xenograft in nude mice. Methods: C225-USPIO was designed by conjugating ultra-small superparamagnetic iron oxide (USPIO) nanoparticles with cetuximab (C225). The diameter of C225-USPIO was detected. Nasopharyngeal carcinoma cells SUNE1 5-8F with EGFR overexpression were transplanted into the ventral subcutaneous site of the right rear thigh of 12 nude mice. When the diameter of a transplanted tumor reached 5 mm, the nude mice were randomly divided into two groups, i.e., the experiment group (Group One) and the control group (Group Two), with 6 mice in each group. C225-USPIO and USPIO were separately injected into the mice through the caudal vein. MRI T2 weighted image (T2WI) scanning was conducted 0, 8, 24 and 72 h after the injection. The nano-contrast agent distribution in the tumor tissues was detected. Results: The diameter of the contrast agent ranged from 45 run to 50 nm. MRI results showed that compared with the value of T2WI signal intensity 0 h after the contrast agent injection, the T2 value of the xenograft tumor in Group One was slightly decreased 8 h after the injection (P>0.05). The value was significantly decreased 24 h after the injection (P<0.05), and no apparent change in the T2 value was observed 72 h after the injection (P>0.05). In Group Two, no significant changes in the T2 value of xenograft tumor after the USPIO injection were observed at each time point. No significant iron particles were found in the tumor tissue 72 h after the injection. Conclusion: C225-USPIO particles could pass through blood capillaries and could be applied for MR imaging in vivo. In addition, they can reduce MRI T2 signal intensity of the xenograft in nude mice with a certain specificity and targeting property.%目的:制备针对EGFR的靶向纳米造影剂C225

  8. Structure and Properties of the Hardmetal Coatings Cr3C2-25NiCr Formed by a Multi-chamber Detonation Sprayer

    Directory of Open Access Journals (Sweden)

    Kovaleva M.G.

    2015-01-01

    Full Text Available The hardmetal Cr3C2-25NiCr (180-220 μm thick coatings have been produced on a steel substrate by a multi-chamber detonation sprayer (MCDS. The characteristic feature of MCDS is that the powder is accelerated by using combustion products that are formed in MCDS chambers and are converged before entering the nozzle, where they interact with the two-phase gas-powder cloud. The microstructures and properties of the hardmetal coatings were examined with the use of optical microscopy, scanning electron microscopy, X-ray phase analysis, and a Vickers hardness tester with a 300 g test load. Wear tests were carried out using a computer controlled pin-on-disc type tribometer. It was established that MCDS has provided the conditions for formation of a dense hardmetal Cr3C2-25NiCr (180-220 μm thick coatings with a porosity of less than 0.02%, microhardness 540±210 HV0.3 and a specific wear rate of 9.08∙10-5 mm3(m∙N-1.

  9. Enhancement of physical protection measures and observation on future JAEA's measures reflecting INFCIRC/225/Rev.5 (Draft) under consideration at IAEA

    International Nuclear Information System (INIS)

    The revised Nuclear Reactor Regulation Law is aimed at strengthening of the physical protection taking into account of INFCIRC/225/Rev.4 (Corrected) requirements by focusing on introducing confidentiality of secret information concerning the protection of the specific nuclear fuel material, physical protection inspection, and Design Basis Threat (DBT) following latest recommendations by International Atomic Energy Agency (IAEA), enforced in December, 2005. Japan Atomic Energy Agency (JAEA) possesses many facilities using Plutonium that fulfill the requirements of Category I and applicable DBT. In order to respond to the revised law, JAEA has conducted (a) development of information management manual for the reinforcement of the physical protection information control, (b) evaluation of the implementation of physical protection measures based on the DBT presented by the competent authority, and (c) enhancement of physical protection measures based on the evaluation result. Moreover, the inspection of physical protection measures and the verification of compliance with the physical protection regulation by competent authority were conducted for each JAEA facility, and the additional corresponding measures to reflect an inspection result were conducted. In this paper,we brief the requirements for the facility using Plutonium, an overview of the instruction by competent authority, an overview of corresponding measures by JAEA. Furthermore, we describe an image of a future physical protection system of JAEA's plutonium facilities influenced by the enhancement of physical protection measures following the recommendation document for the physical protection of nuclear material and nuclear facilities (INFCIRC/225/Rev.5 (Draft)) currently under consideration by IAEA. (author)

  10. Enhancement of Physical Protection Measures and Observation on Future JAEA's Measures Reflecting INFCIRC/225/Rev.5 (Draft) under Consideration at IAEA

    International Nuclear Information System (INIS)

    The revised Nuclear Reactor Regulation Act was aimed at strengthening of the physical protection taking into account of INFCIRC/225/Rev.4 (Corrected) requirements by focusing on introducing confidentiality of secret information concerning the protection of the specific nuclear material, physical protection inspection, and Design Basis Threat (DBT) following latest recommendations by International Atomic Energy Agency (IAEA), enforced in December, 2005. Japan Atomic Energy Agency (JAEA) possesses many facilities using Plutonium that fulfill the requirements of Category I and applicable DBT. In order to respond to the revised law, JAEA has conducted (a) development of information management manual for the reinforcement of the physical protection information control, (b) evaluation of the implementation of physical protection measures based on the DBT presented by the competent authority, and (c) enhancement of physical protection measures based on the evaluation result. Moreover, the inspection of physical protection measures and the verification of compliance with the physical protection regulation by competent authority were conducted for each JAEA facility, and the additional corresponding measures to reflect an inspection result were conducted. In this paper, we brief the requirements for the facility using Plutonium, an overview of the instruction by competent authority, an overview of corresponding measures by JAEA. Furthermore, we describe an image of a future physical protection system of JAEA's plutonium facilities influenced by the enhancement of physical protection measures following the recommendation document for the physical protection of nuclear material and nuclear facilities (INFCIRC/225/Rev.5 (Draft)) currently under consideration by IAEA. (author)

  11. Study on the mechanism of de-embrittlement based on the theory of grain boundary segregation for 2.25Cr-1Mo steel

    International Nuclear Information System (INIS)

    Research highlights: → Mechanism of embrittlement and de-embrittlement for 2.25Cr-Mo steel was studied. → The critical temperature of embrittlement for embrittled material was proposed firstly. → Segregation model that element P segregates to intragranular from grain boundary was deduced. → Auger electron spectroscopy analysis were conducted for hydrogenation reactor after 12 years. → Discussing de-embrittled process and method of embrittled heat treating. - Abstract: The mechanism of embrittlement and de-embrittlement for 2.25Cr-1Mo steel was studied based on the theory of grain boundary segregation, and the idea of critical temperature of embrittlement for embrittled material was proposed according to the iso-segregation curve in this paper. There is one critical embrittlement temperature corresponding to each degree of embrittlement. When further heat treating temperature is higher than critical temperature, it is a de-embrittlement process. Otherwise, it is an embrittlement process. The model of segregation that element P segregates to intragranular from grain boundary in the de-embrittlement process was deduced based on the theory of atom diffusion. The de-embrittled test and Auger electron spectroscopy analysis were conducted for the matrix of hydrogenation reactor served for 12 years, and the theoretical calculation is consistent with the experimental results, which indicates that the further embrittlement or de-embrittlement mechanism can be explained both qualitatively and quantitatively with combination of the theory of iso-segregation curve and the de-embrittled model derived.

  12. Level structure of 217Rn and 221Ra investigated in the alpha-decay 225Th → 221Ra → 217Rn

    International Nuclear Information System (INIS)

    The nuclei 221Ra and 217Rn have been investigated in the α-decay chain 225Th → 221Ra → 217Rn through γ-ray and conversion-electron studies. The short-lived 225Th nuclei (T1/2=8 min) were produced in the 226Ra(α, 5n) reaction, and γ-rays and conversion electrons were measured - between the irradiation periods - in coincidence with α-particles. In 221Ra the five lowest levels are interpreted as members of a K=5/2 parity-doublet with ΔEπ=104 keV. These levels, as well as a higher-lying Kπ=3/2+ band, are consistent with an octupole deformation of 221Ra, as expected from theoretical considerations. In 217Rn only three excited levels are observed, with a favoured α-decay to a 5/2+ excited level thus establishing positive parity for the ground state of 221Ra. (orig.)

  13. Thermodynamic Evaluation of Carbide Precipitates in 2.25Crfraction three-quarters 1.0Mo Steel for Determination of Service Degradation

    Directory of Open Access Journals (Sweden)

    Marinkovic Bojan A.

    2002-01-01

    Full Text Available The 2.25Crfraction three-quarters1.0Mo steel is widely used in petroleum refining units, for example, in pressure vessels, working under severe operational conditions. Due to the high temperatures of some processes, many phenomena such as precipitation of carbides and their coarsening occur during service, resulting in changes of material microstructure. Such changes may modify the mechanical properties, which are responsible for the performance of the pressure vessels. Using a software for thermodynamic calculations, the thermodynamically stable carbides over the temperature range of interest (700-1040 K were evaluated, supposing ferrite as the original microstructure. The theoretical carbide nucleation sequence was also established. Moreover, the theoretical amount of thermodynamically stable carbides and the fraction of Fe, Cr and Mo in the metallic sublattice of M23C6 were determined as a function of temperature. These theoretical calculations were compared to some experimental results on carbide precipitation in the 2.25Crfraction three-quarters1.0Mo steel and two approaches for evaluating the service degradation were proposed. The first one is based on the amount of precipitated M23C6 and the other on the Fe/Cr ratio in the M23C6 carbide.

  14. System for recovery of daughter isotopes from a source material

    Science.gov (United States)

    Tranter, Troy J [Idaho Falls, ID; Todd, Terry A [Aberdeen, ID; Lewis, Leroy C [Idaho Falls, ID; Henscheid, Joseph P [Idaho Falls, ID

    2009-08-04

    A method of separating isotopes from a mixture containing at least two isotopes in a solution is disclosed. A first isotope is precipitated and is collected from the solution. A daughter isotope is generated and collected from the first isotope. The invention includes a method of producing an actinium-225/bismuth-213 product from a material containing thorium-229 and thorium-232. A solution is formed containing nitric acid and the material containing thorium-229 and thorium-232, and iodate is added to form a thorium iodate precipitate. A supernatant is separated from the thorium iodate precipitate and a second volume of nitric acid is added to the thorium iodate precipitate. The thorium iodate precipitate is stored and a decay product comprising actinium-225 and bismuth-213 is generated in the second volume of nitric acid, which is then separated from the thorium iodate precipitate, filtered, and treated using at least one chromatographic procedure. A system for producing an actinium-225/bismuth-213 product is also disclosed.

  15. Use of Radioactive Ion Beams for Biomedical Research 1. in vivo labelling of monoclonal antibodies with radio-lanthanides and $^{225}$Ac

    CERN Document Server

    2002-01-01

    % IS330 \\\\ \\\\\\begin{enumerate} \\item The aim of this study was to contribute to developments of new radiopharmaceuticals for tumour diagnosis and therapy. CERN-ISOLDE is the leading facility in the world to provide radioactive ion beams with high selectivity, purity and intensity. Radioisotope production by spallation makes available a complete range of rare earth isotopes having as complete a diversity of types and energy of radiation, of half-life, and of ionic properties as one would wish. The availability of exotic nuclei, e.g. radionuclides of rare earth elements and $^{225}$Ac, opens new possibilities for the development of radiopharmaceuticals for diagnosis and therapy.\\\\ \\\\ \\item Two approaches were followed within the experimental program. The radioactive metal ions are bound either to bio-specific ligands (monoclonal antibodies or peptides) or to unspecific low molecular weight form. The aim of the experimental program is to evaluate relationships between physico-chemical parameters of the tracer m...

  16. Determination of Neutron Irradiation-Induced Phosphorus Segregation on Grain Boundaries in a P-doped 2.25Cr1Mo Steel

    Institute of Scientific and Technical Information of China (English)

    Shenhua SONG; R.G.Faulkner; P.E.J. Flewitt; Dongdong SHEN; Jing LIU; Zexi YUAN

    2004-01-01

    Irradiation-induced impurity segregation to grain boundaries is one of the important radiation effects on materials.For this reason, phosphorus segregation to prior austenite grain boundaries in a P-doped 2.25Cr1Mo steel subjected to neutron irradiation is examined using field emission gun scanning transmission electron microscopy (FEGSTEM) with energy dispersive X-ray microanalysis (EDX). The steel samples are irradiated around 270 and 400℃, respectively.The irradiation dose rate and dose are ~1.05×10-8 dpa/s and ~0.042 dpa respectively for 270℃ irradiation, and 1.7×10-8 dpa/s and 0.13 dpa respectively for 400℃ irradiation. The FEGSTEM results indicate that there is no apparent phosphorus segregation during 270℃ irradiation but there is some during 400℃ irradiation.

  17. Deformation of Zr41 Ti14 CU12.5 Ni10 Be22.5 bulk amorphous alloy under isobaric pressure in super-cooled liquid region

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ke-qin; LU Qi-zhu

    2005-01-01

    The curve of crystallization transition during continuous heating for the Zr41Ti14Cu12.5Ni10Be22.5 bulk amorphous alloy was measured by means of dilatation(Fully automatic transformation recording/measuring instrument) and X-ray diffraction(XRD) method. The deformation behavior of the alloy at various heating rates in the supercooled liquid region was studied. The results show that the glass transition temperature of the alloy increases slightly and the supercooled liquid region(SLR) increases significantly with increasing heating rate. The deformation amount under isobaric pressure of 1 N for the alloy in the SLR increases with increasing heating rate. As the heating rate of the alloy increases from 5 to 100 ℃/min, the amount of deformation of the alloy increases from 8.3% to 45%.

  18. A molecular dynamics study of the structural change differences between Au225 and Au369 clusters on MgO surfaces at low temperature

    Institute of Scientific and Technical Information of China (English)

    Zhang Lin; Wang Shao-Qing; Chen Nan-Xian

    2012-01-01

    The differences in structural change between Au225 and Au369 clusters with their (111) facets supported on MgO(100) surfaces at 5 K are studied by using molecular-dynamics simulations with the atomic interchange potentialsof the Au/MgO interface.The parameters are obtained from the ab initio energies using the Chen-M(o)bius inversion method.Analyses of the pair distribution functions show that the two Au clusters use different deformation processes to adjust the distances between the interface atoms,owing to the misfit between the atom distances among the clusters and the substrates.The local structural changes are identified by atomic density profiles.

  19. Effects of Phosphorus Grain Boundary Segregation and Hardness on the Ductile-to-Brittle Transition for a 2.25CrlMo Steel

    Institute of Scientific and Technical Information of China (English)

    SONG Shenhua; YUAN Zexi; SHEN Dongdong; WENG Luqian

    2007-01-01

    The combined effect of phosphorus grain boundary segregation and hardness on the ductileto-brittle transition was examined for a P-doped 2.25Crl Mo steel by using Auger electron spectroscopy in conjunction with hardness measurements, Charpy impact tests and scanning electron microscopy. With prolonging time at 540 ℃ after water quenching from 980 ℃, the segregation of phosphorus increases and the hardness decreases. The DBTT (FATT) increases with increasing phosphorus segregation and decreases with decreasing hardness. The effect of phosphorus segregation is dominant until 100 h aging and after that the hardness effect becomes dominant. This effect makes the DBTT (FATT) decrease with further prolonging ageing time although the segregation of phosphorus still increases strongly.

  20. Studies on Hot Corrosion of the Microstructurally Different Regions of 2.25Cr-1Mo (T22) Boiler Tube Steel Weldment

    Science.gov (United States)

    Kumar, Ravindra; Tewari, V. K.; Prakash, Satya

    2009-10-01

    This study examines the effect of microstructurally different regions on the hot corrosion of tungsten inert gas weldment in 2.25Cr-1Mo (T22) boiler tube steel. Various regions of weldment were oxidized in molten salt Na2SO4-60% V2O5 environment at 900 °C. The base metal was found to oxidize at much higher rates than the weld metal and the heat-affected zone. Oxide scales formed in the three regions were compared by scanning electron microscopy with energy dispersive of X-ray analysis, X-ray diffraction pattern, and electron probe microanalysis. The research investigates the formation of inner scales with free Cr over the HAZ.

  1. Nanocrystalline grains growth of Zr_(41.2)Ti_(13.8)Ni_(10)Cu_(12.5)Be_(22.5) bulk amorphous alloy in initial stages%Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10)Be_(22.5)块体非晶合金晶化初期纳米晶粒生长

    Institute of Scientific and Technical Information of China (English)

    彭德林

    2010-01-01

    利用电弧熔炼及铜模快速铸造的方法制备Zr_(41.2)Ti_(13.8)Cu_(12.5)Ni_(10)Be_(22.5)块体非晶合金,通过高分辨电子显微镜研究过冷液相区和晶化初期晶核的形成、纳米晶粒长大.结果表明,Zr_(41.2)Ti_(13.8)Ni_(10)Cu_(12.5)Be_(22.5)块体非晶合金晶化初期,利用高分辨像能观察到晶格点阵特征条纹.很难区分过冷液相区内微小区域的结构特征,借助高分辨像的傅里叶变换技术很容易地辨别出晶化前与相分离有关的结构变化.纳米晶粒以聚合型和单独晶核两种方式生长.

  2. Cinética de degradación del naftaleno por células inmovilizadas húmedas de Bacillus alcalophilus cepa IDO-225

    Directory of Open Access Journals (Sweden)

    Roberto Rafael Núñez Moreira

    2004-01-01

    Full Text Available Numerosas han sido las investigaciones sobre el estudio de la biorremediación para su aplicación en la lucha para combatir la contaminación ambiental por hidrocarburos. El Instituto de Oceanología del Ministerio de Ciencia, Tecnología y Ambiente, ha trabajado desde 1988 en el aislamiento y conservaci ón de bacterias marinas que sean capaces de degradar el petróleo. Actualmente, cuenta con cuatro bioproductos degradadores de petróleo en medio marino denominados BIOIL, K-BIOIL, BIOIL-FC e IDO-225. En el presente trabajo, se demuestra por Espectroscopia Infrarroja de las muestras extraídas a los 3, 6, 9, 12 y 15 d de contacto de las células húmedas inmovilizadas de Bacillus alcalophilus cepa IDO-225 en el medio de degradación con el naftaleno, un hidrocarburo del petróleo, que estas son capaces de degradar el naflateno como única fuente de carbono y energía. La degradación de este hidrocarburo por las células inmovilizadas de esta cepa se lleva a cabo mediante un mecanismo que se basa en un modelo cinético de segundo orden correspondiente a un mecanismo de metil-oxidación y b-oxidación, al igual que las células libres de dicha cepa, pero con la diferencia de que en el caso de las células inmovilizadas, el término cuadrático (metil-oxidación es mayor y el término lineal (b-oxidación es menor que en las células libres. En este mecanismo se produce acetil-CoA, el cual se incorpora al ciclo de los acidos tricarboxílicos para formar dióxido de carbono, agua y coenzimas reducidas, las cuales se dirigen a la cadena de transporte electrónica para obtener energía en forma de ATP y garantizar la síntesis de compuestos esenciales y la obtención de energía.

  3. 经脐孔腹腔镜阑尾切除术225例临床观察%Clinical research on laparoscopic appendectomy through umbilicus

    Institute of Scientific and Technical Information of China (English)

    符松; 王苏明

    2013-01-01

    Objective To explore the feasibility and therapeutic experience of laparoscopic appendectomy through umbilicus in children. Methods 225 cases of acute appendicitis were treated with umbilical single hole laparoscopic appendectomy. For umbilical 1. 0cm incision, insert two 0. 5cm Trocar insertion forceps injury Profiler abdominal organs to find appendectomy grip appendix tip, the appendix completely pulled out from the umbilical abdominal resection using conventional open appendectomy processing the appendix and its mesentery, the completion of the appendectomy. Results The operative time was 10 to 40min ( 20±6. 55 min). The postoperative exhaust time was 4 to 24h (16±5. 45) h. There was no short-term complications. The abdomen has no incision scar. Conclusion The umbilical single-hole method laparoscopic appendectomy is a simple, effective surgical method in the treatment of pediatric appendicitis and it can make the part appendicitis operation become a cosmetic surgery and to become a part of the appendicitis surgery cosmetic surgery.%目的 探讨经脐部单孔法腹腔镜小儿阑尾切除术的可行性及治疗经验.方法 对225例小儿急性阑尾炎采用脐部单孔法腹腔镜阑尾切除术,并观察其疗效.结果 本组手术时间10~40min,平均(20士6.55)min,术后排气时间4~24h,平均(16士5.45)h.术后切口全部Ⅰ期愈合,无近期并发症.腹部未见切口瘢痕.结论 脐部单孔法腹腔镜阑尾切除术是小儿阑尾炎治疗中简洁、有效的手术方法之一,可使部分阑尾炎手术成为一种美容手术.

  4. Influence of Phase Constitution on Mechanical Performance of 12Ce-3Y-ZrO2/2.5 wt pct Al2O3 Composites

    Institute of Scientific and Technical Information of China (English)

    Shuigen HUANG; Lin LI; J.Vlugels; O.V.D.Biest

    2004-01-01

    The phase constitution of a composite consisting of 12 at. Pct CeO2-3 at. Pct Y2O3-ZrO2/2.5 wt pct Al2O3 (3Y12Ce2.5Al) was determined by thermodynamic calculation. It is a combination of 36.9 at. Pct cubic phase and 63.1 at. Pct tetragonal phase at 1450℃. Green compacts were fabricated by cold isostatic pressing with powder synthesized by coating technique, and pressureless sintered at 1450℃. The fracture toughness and Vickers hardness, evaluated by the micro-indentation method, are 2.02 Mpa·m1/2 and 11.395 Gpa, respectively. The addition of 3 at. Pct Y2O3 to 12 at. Pct CeO2-ZrO2 ceramic leads to drastically decrease in toughness compared to composites without yttria stabilizer. No monoclinic phase is detected on the surface of all the ground samples. The high content of cubic phase and lack of phase transformation can be attributed to the low toughness based on the thermodynamic prediction.

  5. 窒息新生儿225例血糖分析%Analysis of the blood sugar in asphyxial neonates

    Institute of Scientific and Technical Information of China (English)

    吴起武

    2009-01-01

    目的 探讨窒息新生儿血糖的变化.方法 对225例窒息新生儿和43例对照组新生儿进行血糖检测和分析.结果 窒息组和对照组血糖水平比较差异无统计学意义[(3.85±2.01)与(4.37±1.01),P>0.05],重度窒息组血糖水平和高血糖发生率均显著高于轻度窒息组(均P 0.05]. The quantity of blood sugar and the incidence rate of hyperglycosemia in seriously asphyxial group were more greater than slightly asphyxial group(P <0.01). The quantity of blood sugar in slighdy asphyxial group was less than the control group (P < 0.05). The quantiy of blood sugar in asphyxial premature infants was significantly less than asphyxial full-term infants(P < 0.05). Conclusions The blood sugar level in asphyxial neonates is relative to the degree of asphyxia and gestational age. The blood sugar in highly asphyxial neonates rise whereas in slightly as-phyxial neonates and asphyxial premature infants reduce.

  6. Finite element analysis of type IV cracking in 2.25Cr-1Mo steel weldment based on micro-mechanistic approach

    Science.gov (United States)

    Goyal, Sunil; Laha, K.; Chandravathi, K. S.; Parameswaran, P.; Mathew, M. D.

    2011-08-01

    Creep studies were carried out on 2.25Cr-1Mo steel base metal and its fusion-welded weldments at 823 K over the stress range 100-240 MPa. The weldment possessed lower creep rupture strength than the base metal due to type IV failure at the outer edge of the heat-affected zone (HAZ). Premature failure of the weldment was associated with pronounced creep cavitation accompanied with localized creep deformation in the soft intercritical region of the HAZ that was sandwiched between relatively higher creep deformation-resistant microstructural regions. The cavitation was associated with coarse intergranular precipitates in the intercritical region of the HAZ. The type IV cracking in the intercritical region of the HAZ was found to initiate deep inside the weldment and propagate towards the specimen surface. Finite element analysis of stress and strain distributions across the weldment was carried out considering the micro-mechanical strength inhomogeneity across it to explain the observed features of type IV cracking. The estimated higher von-Mises and principal stresses deep inside the intercritical region of the HAZ of the weldment led to the localized creep deformation and preferential cavity nucleation and growth, resulting in type IV failure of the weldment. The role of intergranular precipitate particles in the intercritical region of the HAZ in facilitating creep cavity nucleation by the exhaustion of creep ductility of the material close to the precipitate was corroborated from finite element analysis of stress and strain distribution around the precipitates.

  7. What is controlling the fragmentation process in the Infrared Dark Cloud G14.225-0.506? Differet level of fragmentation in twin hubs

    CERN Document Server

    Busquet, G; Palau, A; Liu, H B; Zhang, Q; Girart, J M; de Gregorio-Monsalvo, I; Pillai, T; Anglada, G; Ho, P T P

    2016-01-01

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225-0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 microns obtained with APEX and CSO telescopes. The large scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 microns and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be respon...

  8. Keck and VLT Observations of Super-damped Lyman-alpha Absorbers at z=2=2.5: Constraints on Chemical Compositions and Physical Conditions

    CERN Document Server

    Kulkarni, Varsha P; Morrison, Sean; Peroux, Celine; Quiret, Samuel; York, Donald G

    2015-01-01

    We report Keck/ESI and VLT/UVES observations of three super-damped Lyman-alpha quasar absorbers with H I column densities log N(HI) >= 21.7 at redshifts z=2-2.5. All three absorbers show similar metallicities (-1.3 to -1.5 dex), and dust depletion of Fe, Ni, and Mn. Two of the absorbers show supersolar [S/Zn] and [Si/Zn]. We combine our results with those for other DLAs to examine trends between N(HI), metallicity, dust depletion. A larger fraction of the super-DLAs lie close to or above the line [X/H]=20.59-log N(HI) in the metallicity vs. N(HI) plot, compared to the less gas-rich DLAs, suggesting that super-DLAs are more likely to be rich in molecules. Unfortunately, our data for Q0230-0334 and Q0743+1421 do not cover H2 absorption lines. For Q1418+0718, some H2 lines are covered, but not detected. CO is not detected in any of our absorbers. For DLAs with log N(HI) 21.7 may have somewhat narrower velocity dispersions delta v_90 than the less gas-rich DLAs, and may arise in cooler and/or less turbulent gas.

  9. Charged hadron multiplicity fluctuations in Au+Au and Cu+Cu collisions from sqrt(s_NN) = 22.5 to 200 GeV

    CERN Document Server

    Adare, A; Afanasiev, S; Aidala, C; Ajitanand, N N; Akiba, Y; Al-Bataineh, H; Alexander, J; Al-Jamel, A; Aoki, K; Aphecetche, L; Armendariz, R; Aronson, S H; Asai, J; Atomssa, E T; Averbeck, R; Awes, T C; Azmoun, B; Babintsev, V; Baksay, G; Baksay, L; Baldisseri, Alberto; Barish, K N; Barnes, P D; Bassalleck, B; Bathe, S; Batsouli, S; Baublis, V; Bauer, F; Bazilevsky, A; Belikov, S; Bennett, R; Berdnikov, Y; Bickley, A A; Bjorndal, M T; Boissevain, J G; Borel, H; Boyle, K; Brooks, M L; Brown, D S; Bruner, N; Bucher, D; Büsching, H; Bumazhnov, V; Bunce, G; Burward-Hoy, J M; Butsyk, S; Camard, X; Campbell, S; Chai, J S; Chand, P; Chang, B S; Chang, W C; Charvet, J L; Chernichenko, S; Chiba, J; Chi, C Y; Chiu, M; Choi, I J; Choudhury, R K; Chujo, T; Chung, P; Churyn, A; Cianciolo, V; Cleven, C R; Cobigo, Y; Cole, B A; Comets, M P; Constantin, P; Csanad, M; Csrgo, T; Cussonneau, J P; Dahms, T; Das, K; Dávid, G; Dek, F; Deaton, M B; Dehmelt, K; Delagrange, oa H; Denisov, A; d'Enterria, D; Deshpande, A; Desmond, E J; Devismes, A; Dietzsch, O; Dion, A; Donadelli, M; Drachenberg, J L; Drapier, O; Drees, A; Dubey, A K; Durum, A; Dutta, D; Dzhordzhadze, V; Efremenko, Yu V; Egdemir, J; Ellinghaus, F; Emam, W S; Enokizono, A; Enyo, H; Espagnon, B; Esumi, S; Eyser, K O; Fields, D E; Finck, C; Finger, M; Finger, M; Fleuret, F; Fokin, S L; Forestier, B; Fox, B D; Fraenkel, Zeev; Frantz, J E; Franz, A; Frawley, A D; Fujiwara, K; Fukao, Y; Fung, S Y; Fusayasu, T; Gadrat, S; Garishvili, I; Gastineau, F; Germain, M; Glenn, A; Gong, H; Gonin, M; Gosset, J; Goto, Y; Granier de Cassagnac, R; Grau, N; Greene, S V; Grosse-Perdekamp, M; Gunji, T; Gustafsson, H; Hachiya, T; Hadj Henni, A; Haegemann, C; Haggerty, J S; Hagiwara, M N; Hamagaki, AH; Han, R; Hansen, A G; Harada, H; Hartouni, E P; Haruna, K; Harvey, M; Haslum, E; Hasuko, K; Hayano, R; Heffner, M; Hemmick, T K; Hester, T; Heuser, J M; He, X; Hidas, P; Hiejima, H; Hill, J C; Hobbs, R; Hohlmann, M; Holmes, M; Holzmann, W; Homma, K; Hong, B; Hoover, A; Horaguchi, T; Hornback, D; Hur, M G; Ichihara, T; Ikonnikov, V V; Imai, K; Inaba, M; Inoue, Y; Inuzuka, M; Isenhower, D; Isenhower, L; Ishihara, M; Isobe, T; Issah, M; Isupov, A; Jacak, B V; Jia, J; Jin, J; Jinnouchi, O; Johnson, B M; Johnson, S C; Joo, K S; Jouan, D; Kajihara, F; Kametani, S; Kamihara, N; Kamin, J; Kaneta, M; Kang, J H; Kanou, H; Katou, K; Kawabata, T; Kawagishi, T; Kawall, D; Kazantsev, A V; Kelly, S; Khachaturov, B; Khanzadeev, A; Kikuchi, J; Kim, D H; Kim, D J; Kim, E; Kim, G B; Kim, H J; Kim, Y S; Kinney, E; Kiss, A; Kistenev, E; Kiyomichi, A; Klay, J; Klein-Bösing, C; Kobayashi, H; Kochenda, L; Kochetkov, V; Kohara, R; Komkov, B; Konno, M; Kotchetkov, D; Kozlov, A; Krl, A; Kravitz, a A; Kroon, P J; Kubart, J; Kuberg, C H; Kunde, G J; Kurihara, N; Kurita, K; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Lai, Y S; Lajoie, J G; Lebedev, A; Le Bornec, Y; Leckey, S; Lee, D M; Lee, M K; Lee, T; Leitch, M J; Leite, M A L; Lenzi, B; Lim, H; Lika, T; Litvinenko, s A; Liu, M X; Li, X; Li, X H; Love, B; Lynch, D; Maguire, C F; Makdisi, Y I; Malakhov, A; Malik, M D; Man'ko, V I; Mao, Y; Martínez, G; Maek, L; Masui, H; Matathias, F; Matsumoto, T; McCain, M C; McCumber, M; McGaughey, P L; Miake, Y; Mike, P; Miki, K; Miller, sT E; Milov, A; Mioduszewski, S; Mishra, G C; Mishra, M; Mitchell, J T; Mitrovski, M; Mohanty, A K; Morreale, A; Morrison, D P; Moss, J M; Moukhanova, T V; Mukhopadhyay, D; Muniruzzaman, M; Murata, J; Nagamiya, S; Nagata, Y; Nagle, J L; Naglis, M; Nakagawa, I; Nakamiya, Y; Nakamura, T; Nakano, K; Newby, J; Nguyen, M; Norman, B E; Nyanin, A S; Nystrand, J; O'Brien, E; Oda, S X; Ogilvie, C A; Ohnishi, H; Ojha, I D; Okada, H; Okada, K; Oka, M; Omiwade, O O; Oskarsson, A; Otterlund, I; Ouchida, M; Oyama, K; Ozawa, K; Pak, R; Pal, D; Palounek, A P T; Pantuev, V; Papavassiliou, V; Park, J; Park, W J; Pate, S F; Pei, H; Penev, V; Peng, J C; Pereira, H; Peresedov, V; Peressounko, D Yu; Pierson, A; Pinkenburg, C; Pisani, R P; Purschke, M L; Purwar, A K; Qualls, J M; Qu, H; Rak, J; Rakotozafindrabe, A; Ravinovich, I; Read, K F; Rembeczki, S; Reuter, M; Reygers, K; Riabov, V; Riabov, Y; Roche, G; Romana, A; Rosati, M; Rosendahl, S S E; Rosnet, P; Rukoyatkin, P; Rykov, V L; Ryu, S S; Sahlmueller, B; Saitô, N; Sakaguchi, T; Sakai, S; Sakata, H; Samsonov, V; Sanfratello, L; Santo, R; Sato, H D; Sato, S; Sawada, S; Schutz, Y; Seele, J; Seidl, R; Semenov, V; Seto, R; Sharma, D; Shea, T K; Shein, I; Shevel, A; Shibata, T A; Shigaki, K; Shimomura, M; Shohjoh, T; Shoji, K; Sickles, A; Silva, C L; Silvermyr, D; Silvestre, C; Sim, K S; Singh, C P; Singh, V; Skutnik, S; Sluneka, M; Smith, W C; Soldatov, A; Soltz, R A; Sondheim, W E; Sorensen, cS P; Sourikova, I V; Staley, F; Stankus, P W; Stenlund, E; Stepanov, M; Ster, A; Stoll, S P; Sugitate, T; Suire, C; Sullivan, J P; Sziklai, J; Tabaru, T; Takagi, S; Takagui, E M; Taketani, A; Tanaka, K H; Tanaka, Y; Tanida, K; Tannenbaum, M J; Taranenko, A; Tarjn, P; Thomas, a T L; Togawa, M; Toia, A; Tojo, J; Tomaek, L; Torii, H; Towell, R S; Tram, V-N; Tserruya, Itzhak; Tsuchimoto, Y; Tuli, S K; Tydesj, H; Tyurin, N; Uam, T J; Vale, C; Valle, H; van Hecke, o H W; Velkovska, J; Velkovsky, M; Vertesi, R; Veszprmi, V; Vinogradov, A A; Virius, M; Volkov, e M A; Vrba, V; Vznuzdaev, E; Wagner, M; Walker, D; Wang, X R; Watanabe, Y; Wessels, J; White, S N; Willis, N; Winter, D; Wohn, F K; Woody, C L; Wysocki, M; Xie, W; Yamaguchi, Y L; Yanovich, A; Yasin, Z; Ying, J; Yokkaichi, S; Young, G R; Younus, I; Yushmanov, I E; Zajc, W A; Zaudtke, O; Zhang, C; Zhou, S; Zimányi, J; Zolin, L; Zong, X

    2008-01-01

    A comprehensive survey of event-by-event fluctuations of charged hadron multiplicity in relativistic heavy ions is presented. The survey covers Au+Au collisions at sqrt(s_NN) = 62.4 and 200 GeV, and Cu+Cu collisions sqrt(s_NN) = 22.5, 62.4, and 200 GeV. Fluctuations are measured as a function of collision centrality, transverse momentum range, and charge sign. After correcting for non-dynamical fluctuations due to fluctuations in the collision geometry within a centrality bin, the remaining dynamical fluctuations expressed as the variance normalized by the mean tend to decrease with increasing centrality. The dynamical fluctuations are consistent with or below the expectation from a superposition of participant nucleon-nucleon collisions based upon p+p data, indicating that this dataset does not exhibit evidence of critical behavior in terms of the compressibility of the system. An analysis of Negative Binomial Distribution fits to the multiplicity distributions demonstrates that the heavy ion data exhibit we...

  10. Radio galaxies in ZFOURGE/NMBS: no difference in the properties of massive galaxies with and without radio-AGN out to z = 2.25

    CERN Document Server

    Rees, G A; Norris, R P; Cowley, M J; Papovich, C; Glazebrook, K; Quadri, R F; Straatman, C M S; Allen, R; Kacprzak, G G; Labbe, I; Nanayakkara, T; Tomczak, A R; Tran, K -V

    2015-01-01

    In order to reproduce the high-mass end of the galaxy mass-distribution, some process must be responsible for the suppression of star-formation in the most massive of galaxies. Commonly Active Galactic Nuclei (AGN) are invoked to fulfil this role, but the exact means by which they do so is still the topic of much debate, with studies finding evidence for both the suppression and enhancement of star-formation in AGN hosts. Using the ZFOURGE and NMBS galaxy surveys, we investigate the host galaxy properties of a mass-limited (M$_{\\odot}$ $\\ge$ 10$^{10.5}$ M$_{\\odot}$), high-luminosity (L$_{1.4}$ $>$ 10$^{24}$ W Hz$^{-1}$) sample of radio-loud Active Galactic Nuclei to a redshift of z = 2.25. In contrast to low redshift studies, which associate radio-AGN activity with quiescent hosts, we find that the majority of z $>$ 1.5 radio-AGN are hosted by star-forming galaxies. Indeed, the stellar populations of radio-AGN are found to evolve with redshift in a manner that is consistent with the non-AGN mass-similar galax...

  11. Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies: a single-institution study of 225 cases.

    Science.gov (United States)

    Xue, Wen; Sheng, Yan; Weng, Xiangqin; Zhu, Yongmei; Zhao, Yan; Xu, Pengpeng; Fei, Xiaochun; Chen, Xiaoyan; Wang, Li; Zhao, Weili

    2015-12-01

    Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow (BM) infiltration is more commonly present in mature T-cell lymphoid malignancies compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoid malignancies treated in a single institution. These included 29 cases of T-cell lymphoproliferative disorders (T-LPD, all with BM infiltration) and 196 cases of T-/natural-killer-cell lymphoma (T/NKCL, 56 with BM infiltration and 140 without BM infiltration). The estimated 5-year overall survival (OS) rates of T-LPD and T/NKCL were 96.6% and 37.3%, respectively. T-LPD patients were less likely to exhibit poor performance status, advanced disease stage, presence of B symptoms, or abnormal level of serum β-2 microglobulin. With similar pathological characteristics, T/NKCL patients with BM infiltration showed significantly lower response rates and shorter OS than those without BM infiltration (P = 0.0264 and P cell lymphoid malignancies.

  12. Effect of tensile deformation on micromagnetic parameters in 0.2% carbon steel and 2.25Cr-1Mo steel

    Energy Technology Data Exchange (ETDEWEB)

    Moorthy, V.; Vaidyanathan, S.; Jayakumar, T.; Raj, B. [Indira Gandhi Centre for Atomic Research, Kalpakkam (India). Metallurgy and Materials Group; Kashyap, B.P. [Indian Inst. of Tech., Bombay (India). Dept. of Metallurgical Engineering and Materials Science

    1999-04-23

    The influence of prior tensile deformation on the magnetic Barkhausen emission (MBE) and the hysteresis (B-H) curve has been studied in 0.2% carbon steel and 2.25Cr-1Mo steel under different tempered conditions. This study shows that the micromagnetic parameters can be used to identify the four stages of deformation, namely (1) perfectly elastic, (2) microplastic yielding, (3) macroyielding and (4) progressive plastic deformation. However, it is observed that the MBE profile shows more distinct changes at different stages of tensile deformation than the hysteresis curve. It has been established that the beginning of microplastic yielding and macroyielding can be identified from the MBE profile which is not possible from the stress-strain plot. The onset of microplastic yielding can be identified from the decrease in the MBE peak height. The macroyielding can be identified from the merging of the initially present two-peak MBE profile into a single central peak with relatively higher peak height and narrow profile width. The difference between the variation of MBE and hysteresis curve parameters with strain beyond macroyielding indicates the difference in the deformation state of the surface and bulk of the sample.

  13. 三个新HLA等位基因A*24:224,A*24:225和A*24:257的测序鉴定%Identification of 3 novel HLA-A alleles A * 24: 224, A * 24 : 225 and A * 24: 257 by sequence-based typing

    Institute of Scientific and Technical Information of China (English)

    朱传福; 张红卫; 张毅; 聂向民

    2015-01-01

    目的 鉴定3个在中国汉族人群中发现的人类白细胞抗原(human leukocyte antigen,HLA)A位点新等位基因A* 24:224、A* 24:225和A* 24:257.方法 应用双链直接测序分型技术进行中华骨髓库志愿者常规HLA分型,对其中HLA-A位点无完全匹配结果者,采用等位基因特异性扩增测序分型方法进行新等位基因序列鉴定.结果 3例先证者在HLA-A位点分别有一个未知的新碱基序列,3个新序列均与HLA-A* 24:02:01:01最为相近,但在第2外显子分别出现了1或2个的碱基取代,并导致相应的密码子及其编码的氨基酸的改变.结论 3个新碱基序列均确认为HLA-A新等位基因,分别于2012年11月和2013年11月被世界卫生组织HLA因子命名委员会正式命名为HLA-A* 24:224、HLA-A*24:225和HLA-A* 24:257.%Objective To verify 3 novel HLA-A alleles A * 24:224,A * 24:225 and A * 24:257 identified in Chinese Han individuals.Methods No full matched results were obtained at HLA-A locus in HLA typing for China Marrow Donor Program (CMDP) using bi-allelic Sequence-Based Typing (SBT).The novel HLA alleles were identified with allele-specific amplification SBT.Results All of the three probands had a novel nucleotide sequence at HLA-A locus.All of the 3 new sequences are most close to HLA-A* 24:02:01:01 except for 1 or 2 nucleotide substitution in exon 2,which resulted in different changes in corresponding codons and encoded amino acids.Conclusion Three novel HLA-A alleles were confirmed and officially named as HLA-A * 24:224,HLA-A * 24:225 and HLA-A * 24:257 under the GenBank accession numbers JQ899198,JQ924283 and HG003642 by the WHO Nomenclature Committee for Factors of the HLA System in November 2012 and November 2013,respectively.

  14. Zr41Be22.5Ti14Cu12.5Ni10非晶合金摩擦焊工艺及温度场数值模拟%Friction Welding of Zr41Be22.5Ti14Cu12.5Ni10 Bulk Metallic Glass and Numerical Simulation of Temperature Field

    Institute of Scientific and Technical Information of China (English)

    张帅谋; 张雪峰; 陈彪

    2015-01-01

    采用摩擦焊工艺对Zr41Be22.5Ti14Cu12.5Ni10非晶合金进行焊接,通过优化焊接参数,得到焊接接头.采用XRD、TEM、维氏显微硬度计对试样接头进行了测试.结果表明,优化后的焊接参数可以成功得到焊接接头,试样仍保持非晶特性,且接头力学性能有所增加.采用ANSYS软件对摩擦焊进行温度场数值模拟,可以验证摩擦焊的工艺参数选择合理.

  15. Equilibrium viscosity of the Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass-forming liquid and viscous flow during relaxation, phase separation, and primary crystallization

    International Nuclear Information System (INIS)

    The flow behavior of the supercooled Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass-forming liquid is studied in isothermal three-point beam-bending experiments. The experiments lead to the determination of the equilibrium viscosity as a function of temperature. Comparison with other glass-forming liquids shows that the Zr41.2Ti13.8Cu12.5Ni10Be22.5, alloy is a strong liquid, similar to sodium silicate liquids. Flow measurements during phase separation and subsequent formation of crystals embedded in a non-crystalline matrix reveal a dramatic slowdown of the kinetics of the matrix that is expressed in an increase of the viscosity by several orders of magnitude

  16. Studies on Hot Corrosion of the 2.25 Cr-1Mo Boiler Tube Steel and Its Weldments in the Molten Salt Na2SO4-60 pct V2O5 Environment

    Science.gov (United States)

    Kumar, Ravindra; Tewari, V. K.; Prakash, S.

    2007-01-01

    Hot corrosion is mainly due to the dissolution of protective oxides in the molten salt at the metal surface and their reprecipitation at some other sites as nonprotective porous mass. The hot corrosion attack along the grain boundaries leading to subsurface precipitation of oxides and sulfides also contributes to weakening of material. Ferritic steel with 2.25Cr 1Mo is used widely as a candidate material in the steam generating system of power plants. Hot corrosion studies were conducted on 2.25Cr-1Mo unwelded as well as welded steel specimens with molten salt coated after exposure at 900 °C under cyclic conditions. The thermogravimetric technique was used to establish the kinetics of corrosion X-ray diffraction (XRD); scanning electron microscopy/energy-dispersive analysis (SEM/EDAX) was used to analyze the corrosion products.

  17. 基于参数回归模型的2.25Cr-1Mo钢蠕变断裂时间统计分析%Statistical Analysis on Creep Rupture Life of 2.25Cr-1Mo Steel on the Basis of Parameter Regression Models

    Institute of Scientific and Technical Information of China (English)

    郑开云; 吾之英

    2013-01-01

    基于多种寿命数据分布,包括指数(Exponential)、对数正态(Log-Normal)、威布尔(Weibull)、广义Gamma以及对数罗吉斯提克(ILog-Logistic)分布,采用Manson-Haferd时间-温度参数模型对2.25Cr-1Mo(T22)钢的蠕变断裂时间进行了回归分析,对比研究了基于不同分布模型的蠕变断裂时间与温度和应力的关系、模型拟合优度以及各种模型蠕变断裂时间中位值与5%分位值的差异.结果表明:除Exponential分布模型不适用以外,Log-Normal、Weibull、广义Gamma和Log-Logistic分布模型均适用于蠕变断裂时间数据;这4种模型对蠕变断裂时间中位值的估计均相近,但是对低分位值的估计有所不同,特别是在数据分散度较大时,蠕变断裂时间低分位值的差异较为显著,其中Weibull分布模型的蠕变断裂时间低分位值显著低于其他模型,因此,宜采用多种分布模型对2.25Cr-1Mo钢进行综合统计分析,以正确预测其蠕变寿命或长时服役应力.

  18. Documentation associated with the shipping of Hot-Cell Waste from WESF 225-B to the 200W (218-W-3AE) burial grounds under shipment number RSR-37338

    International Nuclear Information System (INIS)

    The purpose of this report is to compile the records generated during the Packaging and Shipping of WESF Hot-Cell Waste from the 225-B Facility to 200W (218-W-3AE) burial grounds. A total of six 55-gallon drums were packaged and shipped using the Chem-Nuc Cask in accordance with WHC-SD-TP-SARP-025, Rev.0 ''Safety Analysis Report for Packaging (Onsite) for Type B Material in the CNS-14-215H Cask''

  19. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    International Nuclear Information System (INIS)

    A technique of selenium purification from 232Th, 238U, 226,228Ra, 227Ac and 40K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  20. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  1. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  2. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  3. Linear free energy relationship applied to trivalent cations with lanthanum and actinium oxide and hydroxide structure

    International Nuclear Information System (INIS)

    Linear free energy relationships for trivalent cations with crystalline M2O3 and, M(OH)3 phases of lanthanides and actinides were developed from known thermodynamic properties of the aqueous trivalent cations, modifying the Sverjensky and Molling equation. The linear free energy relationship for trivalent cations is as ΔGf,MvX0=aMvXΔGn,M3+0+bMvX+βMvXrM3+, where the coefficients aMvX, bMvX, and βMvX characterize a particular structural family of MvX, rM3+ is the ionic radius of M3+ cation, ΔGf,MvX0 is the standard Gibbs free energy of formation of MvX and ΔGn,M3+0 is the standard non-solvation free energy of the cation. The coefficients for the oxide family are: aMvX=0.2705, bMvX=-1984.75 (kJ/mol), and βMvX=197.24 (kJ/molnm). The coefficients for the hydroxide family are: aMvX=0.1587, bMvX=-1474.09 (kJ/mol), and βMvX=791.70 (kJ/molnm).

  4. Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications

    OpenAIRE

    Kovatsch, Matthias; Lanter, Martin; Duquennoy, Simon

    2012-01-01

    Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that pr...

  5. Reflection asymmetry in odd-A and odd-odd actinium nuclei

    International Nuclear Information System (INIS)

    Theoretical calculations and measurements indicate that octupole correlations are at a maximum in the ground states of the odd-proton nuclei Ac and Pa. It has been expected that odd-odd nuclei should have even larger amount of octupole-octupole correlations. We have recently made measurements on the structure of 224Ac. Although spin and parity assignments could not be made, two bands starting at 354.1 and 360.0 keV have properties characteristic of reflection asymmetric shape. These two bands have very similar rotational constants and also similar alpha decay rates, which suggest similarity between the wavefunctions of these bands. These signatures provide evidence for octupole correlations in these nuclides

  6. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    OpenAIRE

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  7. miR-22-5p revealed as a potential biomarker involved in the acute phase of myocardial infarction via profiling of circulating microRNAs.

    Science.gov (United States)

    Maciejak, Agata; Kiliszek, Marek; Opolski, Grzegorz; Segiet, Agnieszka; Matlak, Krzysztof; Dobrzycki, Slawomir; Tulacz, Dorota; Sygitowicz, Grazyna; Burzynska, Beata; Gora, Monika

    2016-09-01

    Acute myocardial infarction (AMI) is a life-threatening episode of coronary artery disease. Recently, circulating myocardial-derived microRNAs (miRNAs) have been reported as potential biomarkers of infarction. The present study aimed to identify differentially expressed miRNAs in patients with ST-segment elevation myocardial infarction that could be potentially dysregulated in response to early myocardial damage. miRNA expression profile analysis was performed using the Serum/Plasma Focus miRNA Polymerase Chain Reaction (PCR) panel of Exiqon A/S (Vedbaek, Denmark) on plasma samples of patients on the first day of AMI (admission) and on samples from the identical patients collected six months following AMI. Selected miRNAs were validated by reverse transcription‑quantitative PCR (RT‑qPCR) using independent patients with AMI and a control group of patients with a stable coronary artery disease. Thirty‑two species of plasma miRNA were differentially expressed (P<0.05) on admission compared with six months following AMI. Subsequent validation in an independent patient group confirmed that miR‑133b and miR‑22‑5p were significantly up‑regulated in the serum of patients with AMI. The receiver operating characteristic (ROC) curve analysis demonstrated a diagnostic utility for miR-22-5p, which has not previously been reported to be associated with AMI. Among the selected miRNAs, miR‑22‑5p represents a novel promising biomarker for the diagnosis of AMI. PMID:27484208

  8. WHAT IS CONTROLLING THE FRAGMENTATION IN THE INFRARED DARK CLOUD G14.225–0.506?: DIFFERENT LEVELS OF FRAGMENTATION IN TWIN HUBS

    Energy Technology Data Exchange (ETDEWEB)

    Busquet, Gemma; Girart, Josep Miquel [Institut de Ciències de l’Espai (CSIC-IEEC), Campus UAB, Carrer de Can Magrans, S/N, E-08193, Cerdanyola del Vallès, Catalunya (Spain); Estalella, Robert [Departament d’Astronomia i Meteorologia, Institut de Ciències del Cosmos (ICC), Universitat de Barcelona (IEEC-UB), Martí i Franquès, 1, E-08028 Barcelona, Catalunya (Spain); Palau, Aina [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, P.O. Box 3-72, 58090 Morelia, Michoacán, México (Mexico); Liu, Hauyu Baobab; Ho, Paul T. P. [Academia Sinica Institute of Astronomy and Astrophysics, Taipei, Taiwan (China); Zhang, Qizhou [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); De Gregorio-Monsalvo, Itziar [European Southern Observatory (ESO), Karl-Schwarzschild-Str. 2, D-85748 Garching (Germany); Pillai, Thushara [Max Planck Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Anglada, Guillem, E-mail: busquet@ice.cat [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía, s/n, E-18008, Granada (Spain)

    2016-03-20

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225–0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 μm obtained with APEX and CSO telescopes. The large-scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 μm and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be responsible for determining the fragmentation level. We estimated several physical parameters, such as the level of turbulence and the magnetic field strength, and we found no significant differences between these hubs. The Jeans analysis indicates that the observed fragmentation is more consistent with thermal Jeans fragmentation compared with a scenario in which turbulent support is included. The lower fragmentation level observed in hub-N could be explained in terms of stronger UV radiation effects from a nearby H ii region, evolutionary effects, and/or stronger magnetic fields at small scales, a scenario that should be further investigated.

  9. Non-isothermal crystallization kinetics of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Sirui [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Wang, Chunju [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin 150080 (China); Ma, Mingzhen [State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004 (China); Shan, Debin, E-mail: shandb@hit.edu.cn [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin 150080 (China); Guo, Bin [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China)

    2014-07-01

    Highlights: • Some kinetics parameters of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy were calculated. • The first and third exothermic peaks at the heating rates of 5 K/min and 10 K/min split into two peaks. • The local Avrami exponents at various heating rates showed different trends under different heating rates. • The growth dimensionality reduced from 2 to 1 as heating rates increase. • The heating rate had significant influence on the growth mechanism during annealing. - Abstract: The thermodynamics and kinetics of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy under non-isothermal condition were evaluated using differential scanning calorimetry (DSC). The first and third exothermic events at the heating rates of 5 K/min and 10 K/min split into two peaks. The local Avrami exponents at various heating rates calculated by the Kolmogorov–Johnson–Mehl–Avrami equations showed different trends. The grain growth was controlled by atom diffusion at all heating rates. But their growth dimensionality reduced from 2 to 1 as heating rates increase at the beginning of crystallization process. The result exhibited that the heating rate had a great influence on growth mechanism, the crystallization peaks of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy separated into two single-step processes for the change of growth dimensionality. Two fragility indexes evaluated by Angell and DA equations were 44 and 42.5, respectively, implying that the as-cast Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} amorphous alloy should be considered as “intermediate glasses”.

  10. Existence of Fe{sup 4+} ions in Co{sub 2.25}Fe{sub 0.75}O{sub 4} spinel ferrite confirmed from SXRD and XANES spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Panda, Manas Ranjan, E-mail: manasranjan056@gmail.com; Bhowmik, R. N. [Department of Physics, Pondicherry University, R.Venkataraman Nagar, Kalapet, Pondicherry-605014 (India); Sinha, A. K. [Indus Synchrotrons Utilization Division, Raja Ramanna Centre for Advanced Technology, Indore-452013 (India)

    2015-06-24

    The Co{sub 2.25}Fe{sub 0.75}O{sub 4} ferrite composition has been prepared by chemical co-precipitation route. The as-prepared sample after annealing at 900°C in air formed single phase cubic spinel structure. Synchrotron X-ray diffraction and X-ray absorption near edge structure (XANES) measurements were used to study charge states of the cations in octahedral and tetrahedral sites of the cubic spinel structure. Raman spectra indicated normal cubic spinel structure. XANES data suggested the existence of Fe{sup 4+} ions in the spinel structure.

  11. Growth of ˜5 cm2V-1s-1 mobility, p-type Copper(I) oxide (Cu2O) films by fast atmospheric atomic layer deposition (AALD) at 225°C and below

    Science.gov (United States)

    Muñoz-Rojas, D.; Jordan, M.; Yeoh, C.; Marin, A. T.; Kursumovic, A.; Dunlop, L. A.; Iza, D. C.; Chen, A.; Wang, H.; MacManus Driscoll, J. L.

    2012-12-01

    Phase pure, dense Cu2O thin films were grown on glass and polymer substrates at 225°C by rapid atmospheric atomic layer deposition (AALD). Carrier mobilities of 5 cm2V-1s-1 and carrier concentrations of ˜1016 cm-3 were achieved in films of thickness 50 - 120 nm, over a >10 cm2 area. Growth rates were ˜1 nm.min-1 which is two orders of magnitude faster than conventional ALD.. The high mobilities achieved using the atmospheric, low temperature method represent a significant advance for flextronics and flexible solar cells which require growth on plastic substrates.

  12. Growth of ∼5 cm2V−1s−1 mobility, p-type Copper(I oxide (Cu2O films by fast atmospheric atomic layer deposition (AALD at 225°C and below

    Directory of Open Access Journals (Sweden)

    D. Muñoz-Rojas

    2012-12-01

    Full Text Available Phase pure, dense Cu2O thin films were grown on glass and polymer substrates at 225°C by rapid atmospheric atomic layer deposition (AALD. Carrier mobilities of 5 cm2V−1s−1 and carrier concentrations of ∼1016 cm−3 were achieved in films of thickness 50 - 120 nm, over a >10 cm2 area. Growth rates were ∼1 nm·min−1 which is two orders of magnitude faster than conventional ALD.. The high mobilities achieved using the atmospheric, low temperature method represent a significant advance for flextronics and flexible solar cells which require growth on plastic substrates.

  13. Embracing a vision of the New Jerusalem (Rv 21:1−22:5 to impact on life and society

    Directory of Open Access Journals (Sweden)

    Martin H. Pohlmann

    2015-03-01

    Full Text Available Apocalyptic biblical literature has played a significant role in motivating and mobilising Christians. As part of this genre, the Apocalypse of John has played this mobilising role within the church throughout its history. Jerusalem is often incorporated into this genre to conjure up different emotions and images to impact many different people. For example, the Jew annually recites the words to fellow Jews at every Passover meal: ‘Next year in Jerusalem’. Most Christians know the hymn ‘The holy city’, originally penned by Frederic Weatherly in 1892. It lifts many a spirit as it conjures up the idea of a beautiful, perfect, heavenly city of God. However, there is more to this apocalyptic vision, which will be explored in this article. The city upholds the hope of decent godly living today. Whilst Jerusalem is a city with an extremely chequered history, it remains to be the launching pad of a dream that believers can embrace in order to impact society for the better. The vision in Revelation 21–22 is the launch of the ‘idea’ of God’s intention for society today, and the ‘implementation impetus’ is the primary role of the church. In the greater scheme of things, the world community is the target group for a better society for everyone.Aanneming van ’n visioen van die Nuwe Jerusalem (Op 21:1–22:5 ten einde ’n invloed op lewe en die samelewing uit te oefen. Apokaliptiese Bybelliteratuur het ’n beduidende rol in die motivering en aansporing van Christengemeenskappe gespeel. Die Openbaring van Johannes het hierdie motiveringsrol deurgaans in die geskiedenis van die kerkas deel van dié genre vertolk. Jerusalem is dikwels hierby ingesluit om ’n verskeidenheid van emosies en beelde op te roep ten einde ’n impak op ’n verskeidenheid mense te maak. Die Jood, byvoorbeeld, haal jaarliks die volgende woorde teenoor mede-Jode tydens die Paasmaaltyd aan: ‘Volgende jaar in Jerusalem’. Die meeste

  14. Effect of Ce on the structure and hydrogen storage properties of V{sub 55}Ti{sub 22.5}Cr{sub 16.1}Fe{sub 6.4}

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Yigang [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China); Chen, Yungui [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China)]. E-mail: ygchen60@yahoo.com.cn; Liang, Hao [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China); Zhou, Xiaoxiao [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China); Wu, Chaoling [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China); Tao, Mingda [School of Materials Science and Engineering, Sichuan University, Chengdu 610064 (China)

    2007-02-21

    In this paper, the effect of rare metal element Ce on the microstructure, activation performance and hydrogen storage properties of V{sub 55}Ti{sub 22.5}Cr{sub 16.1}Fe{sub 6.4} BCC alloy were researched by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS) and pressure-composition-temperature (PCT) measurements. An obvious segregation of Ce happens in the Ce-containing alloys, and the addition of Ce did not change the structure of BCC alloy and the lattice parameter. The activation performance of V{sub 55}Ti{sub 22.5}Cr{sub 16.1}Fe{sub 6.4} is improved greatly by the addition of Ce. The Ce-free alloy cannot absorb hydrogen without being activated under a high temperature, but all Ce-containing alloys can absorb hydrogen rapidly at room-temperature. The absorption and desorption hydrogen capacities and the plateau pressures have no evident change when Ce content increases. Both Ce and CeO{sub 2} were found in the Ce-containing alloys. It was due to the high activation property of Ce, which can react with hydrogen, that the Ce-containing alloys are activated rapidly.

  15. Can CSR Relieve the Financing Constraints of Enterprises?---An Empirical Study Based on 225 Survey Samples%CSR能缓解企业融资约束吗--基于225个调查样本的实证研究

    Institute of Scientific and Technical Information of China (English)

    张胜荣

    2016-01-01

    企业社会责任(CSR)是企业在生产经营过程中要摒弃把利润作为唯一目标的发展理念,对利益相关者承担起相应的责任。本文回顾了CSR与企业融资约束关系的国内外文献,通过问卷获取了225个调查样本的数据,在对数据进行探索性因子分析、信效度分析的基础上,利用相关性分析、方差分析、回归分析对CSR表现与企业融资约束的关系进行了实证研究。结果表明:CSR表现与企业融资约束高度相关,CSR表现越好,企业融资约束程度越低,其中环境责任、股东责任、消费者责任对企业融资约束影响最大。此外,企业规模对企业融资约束没有显著影响,所有制性质与企业融资约束显著相关,国有企业融资约束要远远低于民营企业。因此,企业要增强CSR意识,提高履行CSR的能力和技巧;政府要加强对CSR行为的监督和引导,加大金融对民营企业的支持力度。%Corporate social responsibility (CSR) is that the enterprise must abandon the idea that the profit is the only goal of the development in the process of production and management, and should bear the corresponding responsibility for the stakeholders. The paper reviews the domestic and foreign literatures about the relationship between CSR and financing constraints of corporate, and obtains the data from 225 survey samples by questionnaire. On the basis of exploratory factor analysis, reliability and validity analysis, using correlation analysis, variance analysis, regression analysis, the paper makes an empirical study on the relationship between CSR performance and financing constraints. The results show that CSR performance and financing constraints are highly correlated, the better CSR performance, the lower the degree of financing constraints, in particular, environmental responsibility, shareholder responsibility and consumer responsibility place the greatest impact on financing

  16. 福州市娱乐场所225名女性性服务者艾滋病相关知识及行为特征%AIDS knowledge Levels and Behavior Characteristics of 225 Female Sex Workers in Entertainment Places of Fuzhou City

    Institute of Scientific and Technical Information of China (English)

    陈传刚; 林华; 张宏

    2011-01-01

    [Objective]To understand HIV/AIDS prevention knowledge levels, high-risk behaviors, and HIV infection status among female sex workers in entertainment places, and provide scientific evidence for relevant departments in developing AIDS prevention and control measures.[Methods]A questionnaire survey on AIDS prevention and treatment knowledge was carried out among the female sex workers in 20 entertainment places of Fuzhou City during Nov 2009 -Jan 2010, their blood samples were collected to test for HIV antibody and syphilis antibody.[Results]Of 225 sex workers, 54.7% answered 8 questions about basic knowledge of AIDS prevention correctly.The awareness rate of AIDS knowledge was 76.0%.The percentage of condom use consistently within 1 month was 81.8%.The proportion of condom use in the last sexual behavior was 98.7%.4.0% of the surveyed subjects had drug behaviors.2 ( 0.9% ) were detected HIV positive.[Conclusion]The awareness rate of sex workers in entertainment places is not high.It is urgent to popularize AIDS prevention knowledge among them to prevent HIV spreading from high risk groups to the general population.%目的 了解娱乐场所女性性服务者的艾滋病(AIDS)防治知识、行为和人类免疫缺陷病毒(HIV)感染情况,为有关部门制定艾滋病防治措施提供科学依据.方法 2009年11月-2010年1月期间对福州市20家娱乐场所内从事商业性交易的女性性服务者进行艾滋病防治知识问卷调查,并现场采集血液检测HIV抗体和梅毒抗体.结果 225名女性性服务者中,对调查问卷8道艾滋病防治基本知识题全部答对的占54.7%,艾滋病知识知晓率为76.0%,最近1个月和最近1次与客人发生性关系,每次都使用安全套的分别占81.8%和98.7%,4.0%的调查对象有吸毒行为,检出HIV感染者2例,阳性率为0.9%.结论 娱乐场所女性性服务者对艾滋病防治知识知晓率不高.亟需对她们普及艾滋病预防相关知识,阻止艾滋病由高危人群向一般人群扩散.

  17. An Investigation of Osteoporosis and Related Risk Factors Among 225 Elderly People in Jinzhou%锦州市225名老年人骨质疏松相关症状及危险因素的调查分析

    Institute of Scientific and Technical Information of China (English)

    侯璇; 吴巧凤; 金炜婷; 刘堃

    2014-01-01

    目的:调查锦州市社区患有骨质疏松的老年人群中出现骨质疏松相关症状及其危险因素情况,为社区老年人骨质疏松的预防提供依据。方法采用自行设计的问卷对锦州市225名60周岁及以上患有骨质疏松的社区老年人进行调查,并利用 SPSS 17.0软件进行数据的录入和分析。结果锦州市225名社区老年人中,髋部疼痛13人(5.8%);背疼25人(11.1%);腰疼70人(31.1%);腿疼63人(28.0%);关节疼痛39人(17.3%);脆性骨折20人(8.9%);驼背31人(13.8%);身长缩短93人(41.3%)。晒太阳30分钟及以上的有212人(94.2%);体育锻炼每周3次及以上的有201人(89.3%);静坐时间6 h 以上的有29人(12.9%);补钙(24.4%)和补充维生素 D (16.9%)者较少。各年龄段中饮酒者和味重饮食者以60岁~年龄段居多,补钙者以75岁~和≥80岁最多;饮浓茶、吸烟、饮酒、静坐时间6 h 以上男性多于女性。喝浓茶、吸烟、饮酒、味重饮食、每天晒太阳30 min 以下、体育锻炼每周3次以下、静坐时间长、有激素用药史为危险因素,喜食豆制品、每天晒太阳30 min 以上、体育锻炼每周3次及以上为保护因素。结论避免骨质疏松危险因素,及早采取预防措施对阻止骨质疏松引发相关疾病具有重要意义。%Objective To investigate risk factors and symptoms of osteoporosis among elderly people in communities in the city of Jinzhou, providing preventive measure. Methods A questionnaire survey was carried out among 225 elderly people with osteoporosis who were above 60 years old and lived in communities of Jinzhou City. Data were analyzed by SPSS 17. 0. Results There were 13 people (5. 8% ) with a hip pain, 25 (11. 1% ) with back pain, 70 (31. 1% ) with low back pain, 63 (28. 0% ) with leg pain, 39 (17. 3% ) with joint pain, 20 (8. 9% ) with brittle fracture, 31 (13. 8% ) with hunchback and 93 (41. 3% ) with length shortening. 212 (94. 2% ) people

  18. Global financial crisis and trend of world construction market with perspective of world leading contractors' performance%金融危机影响下的国际建筑市场——2008年全球最大225家国际工程承包商业绩评述

    Institute of Scientific and Technical Information of China (English)

    金锐

    2009-01-01

    @@ 美国杂志(ENR)历年公布的全球最大225家国际工程承包公司业绩是反映国际建筑市场发展状况的一个重要指标.2008年,全球最大的225家国际工程承包商的国际市场营业额为3900.1亿美元,仍然保持了自2003年以来快速增长的态势,且增幅达到了25.7%.

  19. Measurement of Inclusive ep Cross Sections at High Q2 at sqrt(s) = 225 and 252 GeV and of the Longitudinal Proton Structure Function FL at HERA

    CERN Document Server

    Andreev, V.; Baghdasaryan, S.; Begzsuren, K.; Belousov, A.; Belov, P.; Boudry, V.; Brandt, G.; Brinkmann, M.; Brisson, V.; Britzger, D.; Buniatyan, A.; Bylinkin, A.; Bystritskaya, L.; Campbell, A.J.; Cantun Avila, K.B.; Ceccopieri, F.; Cerny, K.; Chekelian, V.; Contreras, J.G.; Dainton, J.B.; Daum, K.; De Wolf, E.A.; Diaconu, C.; Dobre, M.; Dodonov, V.; Dossanov, A.; Dubak, A.; Eckerlin, G.; Egli, S.; Elsen, E.; Favart, L.; Fedotov, A.; Feltesse, J.; Ferencei, J.; Fleischer, M.; Fomenko, A.; Gabathuler, E.; Gayler, J.; Ghazaryan, S.; Glazov, A.; Goerlich, L.; Gogitidze, N.; Gouzevitch, M.; Grab, C.; Grebenyuk, A.; Greenshaw, T.; Grindhammer, G.; Habib, S.; Haidt, D.; Henderson, R.C.W.; Herbst, M.; Hildebrandt, M.; Hladky, J.; Hoffmann, D.; Horisberger, R.; Hreus, T.; Huber, F.; Jacquet, M.; Janssen, X.; Jung, A.W.; Jung, H.; Kapichine, M.; Kiesling, C.; Klein, M.; Kleinwort, C.; Kogler, R.; Kostka, P.; Kretzschmar, J.; Kruger, K.; Landon, M.P.J.; Lange, W.; Laycock, P.; Lebedev, A.; Levonian, S.; Lipka, K.; List, B.; List, J.; Lobodzinski, B.; Lubimov, V.; Malinovski, E.; Martyn, H.U.; Maxfield, S.J.; Mehta, A.; Meyer, A.B.; Meyer, H.; Meyer, J.; Mikocki, S.; Morozov, A.; Muller, K.; Naumann, Th.; Newman, P.R.; Niebuhr, C.; Nowak, G.; Nowak, K.; Olivier, B.; Olsson, J.E.; Ozerov, D.; Pahl, P.; Pascaud, C.; Patel, G.D.; Perez, E.; Petrukhin, A.; Picuric, I.; Pirumov, H.; Pitzl, D.; Placakyte, R.; Pokorny, B.; Polifka, R.; Radescu, V.; Raicevic, N.; Raspereza, A.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Rusakov, S.; Salek, D.; Sankey, D.P.C.; Sauter, M.; Sauvan, E.; Schmitt, S.; Schoeffel, L.; Schoning, A.; Schultz-Coulon, H.C.; Sefkow, F.; Shushkevich, S.; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, A.; Steder, M.; Stella, B.; Straumann, U.; Sykora, T.; Thompson, P.D.; Traynor, D.; Truol, P.; Tsakov, I.; Tseepeldorj, B.; Turnau, J.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vazdik, Y.; Wegener, D.; Wunsch, E.; Zacek, J.; Zhang, Z.; Zlebcik, R.; Zohrabyan, H.; Zomer, F.

    2014-01-01

    Inclusive ep double differential cross sections for neutral current deep inelastic scattering are measured with the H1 detector at HERA. The data were taken with a lepton beam energy of 27.6 GeV and two proton beam energies of Ep = 460 and 575 GeV corresponding to centre-of-mass energies of 225 and 252 GeV, respectively. The measurements cover the region of 6.5 *10^{-4}<=x<= 0.65 for 35<=Q^2<=800 GeV^2 up to y = 0.85. The measurements are used together with previously published H1 data at Ep = 920 GeV and lower Q2 data at Ep = 460, 575 and 920 GeV to extract the longitudinal proton structure function FL in the region 1.5<=Q^2 <=800 GeV^2.

  20. 他们凭什么站在世界之巅——2005年度全球225家最大国际承包商简评

    Institute of Scientific and Technical Information of China (English)

    付勇生

    2006-01-01

    近日,美国麦格劳一希尔公司(McGraw-Hill)旗下的杂志《工程新闻记录》(ENR)公布了2005年度的225家最大国际承包商排名榜。随着近几年国际工程承包市场的迅逋蔓曼展,国际承包商的整体实力有了较大提高,因而今年的入门门槛提高到2300万美元的国际市场营业额。

  1. 也们凭什么站在世界之巅?——2005年度全球225家最大国际承包商简评

    Institute of Scientific and Technical Information of China (English)

    付勇生

    2006-01-01

    近日,美国麦格劳-希尔公司(McGraw-Hill)旗下的杂志《工程新闻记录》(ENR)公布了2005年度的225家最大国际承包排名榜。随着近几年国际工程系承包市场的迅速发展,国际承包商的整体实力有了较大的提高,因而今年的入门门槛提高到2300万美元的国际市场营业额。

  2. Ozone decline and its effect on night airglow intensity of Na 5893°A at Dumdum (22.5°N, 88.5° E) and Halley Bay (76°S, 27°W)

    Indian Academy of Sciences (India)

    P K Jana; S C Nandi

    2006-10-01

    The paper presents the effect of O3 depletion on night airglow emission of Na 5893 A line at Dumdum (22.5°N, 88.5°E), India and Halley Bay (76°S, 27°W), a British Antarctic service station. Calculations based on chemical kinetics show that the airglow intensity of Na 5893 A line will also be affected due to the depletion of O3 concentration. The nature of yearly variation and seasonal variation of the intensity of Na 5893 A line for the above two stations are shown and compared. It is shown that the rate of decrease of intensity of Na 5893 A line is comparatively more at Halley Bay due to the dramatic decrease of Antarctic O3 concentration. A possible explanation for this dramatic decrease of Antarctic O3 concentration is also mentioned.

  3. Third-Order Elastic Constants and Anharmonic Properties of the Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 Bulk Metallic Glass

    Institute of Scientific and Technical Information of China (English)

    WANG Ru-Ju; LI Feng-Ying; QIN Zhi-Cheng; WANG Wei-Hua

    2001-01-01

    The longitudinal velocity V1 and shear velocity Vs of an ultrasonic wave propagated along three arbitrary perpendicular directions of the Zr41.2 Ti13.8Cu12.5Ni10.0Be22.5 bulk metallic glass (Zr/Ti BMG) have been measured at ambient pressure, under hydrostatic pressure (up to 0.5 GPa) and uniaxial compression (up to 70 MPa) using the pulse echo overlap method. The third-order elastic constants and the Gruneisen parameter related to the anharmonic properties were derived and discussed. It was found that the BMG with marked different microstructural characteristics, compared with the amorphous carbon, exhibited different behaviours related to shear vibratory under high pressure.

  4. Estudio del comportamiento del acero 2.25Cr-1Mo frente a los fenómenos de oxidación cíclica e isoterma

    Directory of Open Access Journals (Sweden)

    Proy, Manuel

    2014-03-01

    Full Text Available Cyclic and isothermal oxidation of chromium-molybdenum steel 2.25Cr-1Mo were analyzed at 550 °C and 650 °C during 360 hours in air atmospheres. The cycles were performed with two stages; one of heating in furnace during 90 minutes and then the sample were cooled to 50 °C by air flow. Thermogravimetric analyses were performed to obtain high temperature corrosion kinetics. Several characterization techniques have been used to identify the corrosion mechanism, as X-Ray Diffraction (XRD, Optical Microscopy (OM and Scanning Electron Microscopy (SEM. Thermal cycling tests can changes the corrosion mechanism, due cracks propagation in oxide scale, that witch can favors the access of oxidant agent to the substrate.La resistencia del acero aleado con cromo y molibdeno 2.25Cr-1Mo frente a la oxidación isotérmica y cíclica, fue evaluada a 550 °C y 650 °C durante 360 horas en aire. Los ciclos consistieron en el mantenimiento durante 90 minutos dentro del horno a la temperatura de ensayo y un periodo de enfriamiento forzado hasta 50 °C mediante la aplicación de un flujo de aire. Se realizó un estudio termogravimétrico para calcular las cinéticas de oxidación. Para conocer el mecanismo de degradación, se emplearon diversas técnicas de caracterización microestructural, como Difracción de Rayos (DRX, Microscopía Óptica (MO y Electrónica de Barrido (MEB. El ciclado térmico cambia el mecanismo de degradación, debido a la propagación de grietas en la película de óxido formada, que favorece el acceso del agente agresivo al sustrato.

  5. SUPPRESSION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION BY ESMOLOL ADMINISTERED IN DOSES OF 1.5 mg/kg, 2.25 mg/kg: A COMPARATIVE CLINICAL STUDY

    Directory of Open Access Journals (Sweden)

    Roopa

    2016-03-01

    Full Text Available BACKGROUND Laryngoscopy and endotracheal intubation results in physiological changes of various body systems like heart rate and blood pressure in cardiovascular system. For attenuating the hyperdynamic cardiovascular response to tracheal intubation, numerous trials with many drugs were undertaken. AIM Of our study is to find out the safety and efficacy of attenuation of pressor response during laryngoscopy and tracheal intubation using Esmolol, administered as single intravenous bolus prior to induction of anaesthesia in two different doses of 1.5 mg/kg and 2.25 mg/kg. Control group was considered in our previous study using the same drug with different dosage, i.e. a dose of 0.75 mg/kg was compared with a placebo. We would like to go ahead with further increase in the dosage per kg body weight to get an ideal suppression of the pressor responses. MATERIALS AND METHODS The study was conducted in 50 patients, who were randomly assigned into 2 groups of 25 each. Group A (25 received Inj. Esmolol 1.5 mg/kg and Group B (25 received Inj. Esmolol 2.25 mg/kg IV before induction. RESULTS Heart rate and blood pressures were well maintained within physiological range in Group A, whereas there was a decrease in blood pressure and heart rate in the Group B immediately after intubation and at the end of 4th min. CONCLUSION In this study, the Group B showed an inappropriate decrease in mean values of Heart Rate, Blood Pressure immediately after administration.

  6. 恩施地区儿童癫痫诊治及管理存在的问题(附225例分析)%Issues in Diagnosis, Treatment and Management of Epileptic Children in Enshi (A Retrospective Study of 225 Cases)

    Institute of Scientific and Technical Information of China (English)

    杨倩; 王芳

    2015-01-01

    目的:了解恩施地区儿童癫痫诊治及管理中存在的问题,以提高儿童癫痫的诊治水平。方法对2011年1—12月在我院儿科以癫痫收治患儿225例的诊治情况、癫痫综合征分类、随访及预后情况进行回顾性分析。结果本组中142例(63.1%)曾在外院诊断为癫痫,仅5例(3.5%)进行癫痫综合征分类;46例(32.4%)误漏诊,其中22例癫痫误诊为其他疾病,24例非癫痫误诊为癫痫。116例(81.7%)首诊治疗不正规,92例首次治疗使用2种抗癫痫药物(AEDs),其中农村患儿84例,24例用药剂量不足。来我院后,确诊癫痫201例,仅21例(10.4%)不能进行综合征归类,余180例均按照2010年国际抗癫痫联盟的癫痫分类诊断标准进行分型诊断,22例(10.9%)暂未应用AEDs 治疗,单一AEDs 治疗135例(67.2%),联用2种AEDs 治疗33例(16.4%),联用3种AEDs 治疗11例(5.5%)。随访率79.6%,服药1年内112例(55.7%)擅自减量或停药,农村患儿占44.3%。经治疗症状完全控制121例(60.2%),显效及有效59例(29.4%),无效21例(10.4%)。另24例经相关检查排除癫痫诊断,10例脑性瘫痪治疗后症状好转,余14例治愈。结论对于儿童癫痫的诊断,首先要确定发作类型,再明确癫痫综合征分类,然后按照规范、个体化原则选择疗效确切、依从性好的AEDs 进行治疗。尤其要加强农村癫痫患儿治疗期间的随访跟踪管理。%Objective To discuss diagnosis, treatment and management of epileptic children in Enshi in order to im-prove the levels of diagnosis and treatment. Methods A Retrospective analysis of diagnosis and treatment, classifications and prognosis were made on 225 cases of epileptic children in the department of pediatrics of our hospital during January and De-cember 2011. Results 142 cases (63. 1%) were diagnosed as epilepsy in other hospitals and only 5 cases (3. 5%) were classified as epilepsy syndrome;46 cases (32. 4%) were misdiagnosed, among which, 22 epileptic children

  7. 2.25 Cr-1 Mo和2.25 Cr-1 Mo-0.25 V钢加氢反应器材料和制造经验%Materials and Fabrication Experience of 2 .25 Cr-1 Mo and 2.25 Cr-1 Mo-0.25 V Steel Hydrogenation Reactor

    Institute of Scientific and Technical Information of China (English)

    张颖; 尚尔晶; 谷文

    2014-01-01

    The specifications in ASME code and API standard to material and fabrication of2.25Cr-1Mo and 2.25Cr-1Mo-0.25V steel hydrogenation reactor were introduced.Related requirements about tem-per brittleness,mechanical property and reheat crack of 2.25Cr-1Mo and 2.25Cr-1Mo-0.25V steel in the technical documents of domestic and overseas licensors were summarized.%介绍了ASME规范和API标准对2.25Cr-1Mo钢和2.25Cr-1Mo-0.25V钢材料和制造方面的规定,梳理总结了国内外专利商技术文件对2.25Cr-1Mo钢和2.25Cr-1Mo-0.25V钢焊材和母材在回火脆性、力学性能、再热裂纹等方面的要求。

  8. Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells.

    Science.gov (United States)

    Tripathi, Shubhandra; Srivastava, Gaurava; Sharma, Ashok

    2016-08-01

    Drug resistance poses a threatening challenge for mankind, as the development of resistance to already well-established drugs causes serious therapeutic problems. Resistance to paclitaxel (Ptxl), a complex diterpenoid working as microtubule stabilizer, is one such issue in cancer treatment. Microtubule stabilizer drugs, stabilises microtubules upon binding to β-tubulin subunit of tubulin heterodimer thus causing mitotic arrest leading to death of cancer cell. Leucine point mutations viz. L215H, L217R, and L225M were reported for Ptxl resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations was explored using molecular docking, molecular dynamics (MD) simulation, binding energy estimation (MMPBSA), free energy decomposition, principle component analysis (PCA) and free energy landscape (FEL) methods. A total of five systems including unbound βI-tubulin (Apo), docked wild+Ptxl, L215H+Ptxl, L217R+Ptxl and L225M+Ptxl were prepared, and 50 ns MD simulation was performed for each system. Binding energy estimation indicated that leucine mutation reduces the binding affinity of Ptxl in mutant types (MTs) as compared to wild type (WT). Further, in contrast to WT Ptxl interactions with the M-loop (PHE270-VAL286), S6-S7 loop and H9-H10 were significantly altered in MTs. Results showed that in MTs, Ptxl had weak interaction with M-loop residues, while having strong affinity with S6-S7 loop and H6-H7 loop. Moreover, PCA and FEL analysis revealed that M-loop flexible region (THR274-LEU284) was strongly bound with Ptxl in WT preventing its flexible movement and the causing factor for microtubule stabilization. In MTs due to poor interaction with Ptxl, M-loop flexible region retains its flexibility, therefore unable to stabilize microtubule. This study will give an insight into the importance of M-loop flexible region interaction with Ptxl for microtubule stabilization. In addition, it clearly provides the molecular basis of

  9. Structural phase change in Co{sub 2.25}Fe{sub 0.75}O{sub 4} spinel oxide by vacuum annealing and role of coexisting CoO phase on magnetic properties

    Energy Technology Data Exchange (ETDEWEB)

    Bhowmik, R.N., E-mail: rnbhowmik.phy@pondiuni.edu.in [Department of Physics, Pondicherry University, R.V. Nagar, Kalapet, Pondicherry 605014 (India); Panda, Manas Ranjan [Department of Physics, Pondicherry University, R.V. Nagar, Kalapet, Pondicherry 605014 (India); Yusuf, S.M.; Mukadam, M.D. [Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Sinha, A.K. [Indus Synchrotrons Utilization Division, Raja Ramanna Centre for Advanced Technology, Indore 452013 (India)

    2015-10-15

    The spinel oxide Co{sub 2.25}Fe{sub 0.75}O{sub 4} has been prepared by co-precipitation route. The as prepared material has been annealed at 800 °C under vacuum. Properties of the samples annealed under vacuum have been compared with the sample annealed in air. Synchrotron X-ray diffraction, Raman spectroscopy and X-ray absorption near edge structure spectroscopy have been used for structural phase characterization. The cubic spinel structure in air annealed sample has been splitted into Co and Fe rich phases. The Co rich spinel phase has transformed into Cobalt monoxide (CoO) after vacuum annealing. This has resulted an increase of Fe:Co ratio in the Fe rich spinel phase. Raman spectra indicated a transformation of the distribution of Co and Fe ions from normal spinel like structure for the sample annealed in air to mixed spinel structure for the samples annealed under vacuum. The existence tetravalent Fe{sup 4+} ion has been confirmed in all the samples and it is new information for Co doped spinel ferrite system. All the samples exhibited ferrimagnetic behavior and exchange bias effect. The focus point is that vacuum annealing has been used as an effective route of material processing to control the structural phase and also, enhancement of magnetic properties in Co rich ferrite. - Graphical abstract: M(H) loop of vacuum annealed CoFe8V4 samples (a-e) and air annealed CoFe8A4 sample (f-g) at selected measurement temperatures. The variation of exchange bias field with temperatures for both the samples (h). - Highlights: • Structure and ferrimagnetic properties of Co{sub 2.25}Fe{sub 0.75}O{sub 4} have been reported. • Self-composite structure of material has been tailored by vacuum annealing. • Synchrotron X-ray diffraction and XANES have been used for characterization. • The existence tetravalent Fe{sup 4+} ions in ferrite structure is a new information. • The coexistence of CoO gives a great opportunity for tuning ferrimagnetic parameters.

  10. Demonstration of 575-Mb/s downlink and 225-Mb/s uplink bi-directional SCM-WDM visible light communication using RGB LED and phosphor-based LED.

    Science.gov (United States)

    Wang, Yuanquan; Wang, Yiguang; Chi, Nan; Yu, Jianjun; Shang, Huiliang

    2013-01-14

    We propose and experimentally demonstrate a novel full-duplex bi-directional subcarrier multiplexing (SCM)-wavelength division multiplexing (WDM) visible light communication (VLC) system based on commercially available red-green-blue (RGB) light emitting diode (LED) and phosphor-based LED (P-LED) with 575-Mb/s downstream and 225-Mb/s upstream transmission, employing various modulation orders of quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM). For the downlink, red and green colors/wavelengths are assigned to carry useful information, while blue chip is just kept lighting to maintain the white color illumination, and for the uplink, the low-cost P-LED is implemented. In this demonstration, pre-equalization and post-equalization are also adopted to compensate the severe frequency response of LEDs. Using this scheme, 4-user downlink and 1-user uplink transmission can be achieved. Furthermore, it can support more users by adjusting the bandwidth of each sub-channel. Bit error rates (BERs) of all links are below pre-forward-error-correction (pre-FEC) threshold of 3.8x 10(-3) after 66-cm free-space delivery. The results show that this scheme has great potential in the practical VLC system.

  11. Measurement of inclusive ep cross sections at high Q{sup 2} at √(s) = 225 and 252 GeV and of the longitudinal proton structure function F{sub L} at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Andreev, V.; Belousov, A.; Fomenko, A.; Gogitidze, N.; Lebedev, A.; Malinovski, E.; Rusakov, S.; Vazdik, Y. [Lebedev Physical Institute, Moscow (Russian Federation); Baghdasaryan, A.; Baghdasaryan, S.; Zohrabyan, H. [Yerevan Physics Institute, Yerevan (Armenia); Begzsuren, K.; Ravdandorj, T.; Tseepeldorj, B. [Institute of Physics and Technology of the Mongolian Academy of Sciences, Ulaanbaatar (Mongolia); Belov, P.; Brinkmann, M.; Britzger, D.; Campbell, A.J.; Dodonov, V.; Eckerlin, G.; Elsen, E.; Fleischer, M.; Gayler, J.; Ghazaryan, S.; Glazov, A.; Gouzevitch, M.; Grebenyuk, A.; Habib, S.; Haidt, D.; Kleinwort, C.; Krueger, K.; Levonian, S.; Lipka, K.; List, B.; List, J.; Lobodzinski, B.; Meyer, A.B.; Meyer, J.; Niebuhr, C.; Olsson, J.E.; Ozerov, D.; Pahl, P.; Petrukhin, A.; Pirumov, H.; Pitzl, D.; Placakyte, R.; Radescu, V.; Raspereza, A.; Schmitt, S.; Sefkow, F.; Shushkevich, S.; South, D.; Steder, M.; Wuensch, E. [DESY, Hamburg (Germany); Boudry, V.; Specka, A. [LLR, Ecole Polytechnique, CNRS/IN2P3, Palaiseau (France); Bradt, G. [Oxford University, Department of Physics, Oxford (United Kingdom); Brisson, V.; Jacquet, M.; Pascaud, C.; Zhang, Z.; Zomer, F. [LAL, Universite Paris-Sud, CNRS/IN2P3, Orsay (France); Buniatyan, A.; Huber, F.; Sauter, M.; Schoening, A. [Universitaet Heidelberg, Physikalisches Institut, Heidelberg (Germany); Bylinkin, A.; Bystritskaya, L.; Fedotov, A.; Rostovtsev, A. [Institute for Theoretical and Experimental Physics, Moscow (Russian Federation); Cantun Avila, K.B.; Contreras, J.G. [CINVESTAV, Departamento de Fisica Aplicada, Merida, Yucatan (Mexico); Ceccopieri, F.; Wolf, E.A. de; Favart, L.; Hreus, T.; Janssen, X.; Roosen, R.; Mechelen, P. van [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (Belgium); Cerny, K.; Pokorny, B.; Polifka, R.; Salek, D.; Valkarova, A.; Zacek, J.; Zlebcik, R. [Charles University, Faculty of Mathematics and Physics, Prague (Czech Republic); Chekelian, V.; Grindhammer, G.; Kiesling, C.; Olivier, B. [Max-Planck-Institut fuer Physik, Munich (Germany); Dainton, J.B.; Gabathuler, E.; Greenshaw, T.; Klein, M.; Kretzschmar, J.; Laycock, P.; Maxfield, S.J.; Mehta, A.; Patel, G.D. [University of Liverpool, Department of Physics, Liverpool (United Kingdom); Daum, K.; Meyer, H. [Universitaet Wuppertal, Fachbereich C, Wuppertal (Germany); Diaconu, C.; Hoffmann, D.; Sauvan, E.; Vallee, C. [CPPM, Aix-Marseille Univ, CNRS/IN2P3, Marseille (France); Dobre, M.; Rotaru, M. [National Institute for Physics and Nuclear Engineering (NIPNE), Bucharest (Romania); Dossanov, A. [Universitaet Hamburg, Institut fuer Experimentalphysik, Hamburg (Germany); Max-Planck-Institut fuer Physik, Munich (Germany); Dubak, A. [Max-Planck-Institut fuer Physik, Munich (Germany); University of Montenegro, Faculty of Science, Podgorica (Montenegro); Egli, S.; Hildebrandt, M.; Horisberger, R. [Paul Scherrer Institut, Villigen (Switzerland); Feltesse, J.; Perez, E.; Schoeffel, L. [CEA, DSM/Irfu, CE-Saclay, Gif-sur-Yvette (France); Ferencei, J. [Slovak Academy of Sciences, Institute of Experimental Physics, Kosice (Slovakia); Goerlich, L.; Mikocki, S.; Nowak, G.; Sopicki, P.; Turnau, J. [Institute for Nuclear Physics, Cracow (Poland); Grab, C. [ETH, Institut fuer Teilchenphysik, Zurich (Switzerland); Henderson, R.C.W. [University of Lancaster, Department of Physics, Lancaster (United Kingdom); Herbst, M.; Jung, A.W.; Schultz-Coulon, H.C. [Universitaet Heidelberg, Kirchhoff-Institut fuer Physik, Heidelberg (Germany); Hladka, J.; Reimer, P. [Academy of Sciences of the Czech Republic, Institute of Physics, Prague (Czech Republic); Jung, H. [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (Belgium); DESY, Hamburg (Germany); Kapichine, M.; Morozov, A.; Spaskov, V. [Joint Institute for Nuclear Research, Dubna (RU); Kogler, R.; Nowak, K. [Universitaet Hamburg, Institut fuer Experimentalphysik, Hamburg (DE); Kostka, P.; Lange, W.; Naumann, T. [DESY, Zeuthen (DE); Landon, M.P.J.; Rizvi, E.; Traynor, D. [University of London, School of Physics and Astronomy, Queen Mary, London (GB); Lubimov, V. [Institute for Theoretical and Experimental Physics, Moscow (RU); Martyn, H.U. [I. Physikalisches Institut der RWTH, Aachen (DE); Mueller, K.; Robmann, P.; Straumann, U.; Truoel, P. [Physik-Institut der Universitaet Zuerich, Zurich (CH); Newman, P.R.; Thompson, P.D. [School of Physics and Astronomy, University of Birmingham, Birmingham (GB); Picuric, I.; Raicevic, N. [University of Montenegro, Faculty of Science, Podgorica (ME); Sankey, D.P.C. [STFC, Rutherford Appleton Laboratory, Oxfordshire (GB); Soloviev, Y. [DESY, Hamburg (DE); Lebedev Physical Institute, Moscow (RU); Stella, B. [Universita di Roma Tre (IT); INFN Roma 3, Dipartimento di Fisica, Rome (IT); Sykora, T. [Brussels and Universiteit Antwerpen, Inter-University Institute for High Energies ULB-VUB, Antwerp (BE); Charles University, Faculty of Mathematics and Physics, Prague (CZ); Tsakov, I. [Institute for Nuclear Research and Nuclear Energy, Sofia (BG); Wegener, D. [Institut fuer Physik, TU Dortmund, Dortmund (DE); Collaboration: H1 Collaboration

    2014-04-15

    Inclusive ep double differential cross sections for neutral current deep inelastic scattering are measured with the H1 detector at HERA.The data were taken with a lepton beam energy of 27.6 GeV and two proton beam energies of E{sub p} = 460 and 575 GeV corresponding to centre-of-mass energies of 225 and 252 GeV, respectively. The measurements cover the region of 6.5 x 10{sup -4} ≤ x ≤ 0.65 for 35 ≤ Q{sup 2} ≤ 800 GeV{sup 2} up to y = 0.85. The measurements are used together with previously published H1 data at E{sub p} = 920 GeV and lower Q{sup 2} data at E{sub p} = 460, 575 and 920 GeV to extract the longitudinal proton structure function F{sub L} in the region 1.5 ≤ Q{sup 2} ≤ 800 GeV{sup 2}. (orig.)

  12. Atomic structure of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} bulk metallic glass alloy

    Energy Technology Data Exchange (ETDEWEB)

    Hui, X. [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China)], E-mail: huixd01@hotmail.com; Fang, H.Z.; Chen, G.L. [State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China); Shang, S.L.; Wang, Y. [Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA 16802 (United States); Qin, J.Y. [Key Laboratory of Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University - Southern Campus, Jinan 250061 (China); Liu, Z.K. [Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA 16802 (United States)

    2009-01-15

    Ab initio molecular dynamics (AIMD) calculations were performed on the atomic configuration of Zr{sub 41.2}Ti{sub 13.8}Cu{sub 12.5}Ni{sub 10}Be{sub 22.5} bulk metallic glass. The local structures were characterized in terms of structure factors (SF), pair correlation functions (PCF), coordinate numbers, bond pairs and Voronoi polyhedra. The glass transition temperature, generalized PCF and SF predicated by AIMD are in good agreement with the experimental data. Icosahedral short-range orders (ISRO) are found to be the most dominant, in view of the presence of the majority of bond pairs with 1551, 1541 and 1431, and Voronoi polyhedra with <0,3,6,1>, <0,2,8,1>, <0,0,12,0> and <0,2,8,4>. Icosahedral medium range orders (IMROs) are formed from icosahedra via the linkage of vertex-, edge-, face- and intercross-shared atoms. The glass structure on the nanometer scale is accumulated by polyhedra through an efficient packing mode. It is suggested that the extraordinary glass-forming ability of this alloy is essentially attributable to the formation of ISRO and IMRO, and the dense packing of atoms.

  13. 2012年ENR全球最大225家国际承包商榜单出炉——中国建筑企业比肩国际一流尚须努力

    Institute of Scientific and Technical Information of China (English)

    汪红蕾

    2012-01-01

    日前,美国麦格劳一希尔建筑信息公司(McGraw—Hill)发布了2012年Engineering News—Record(简称ENR)全球最大225家国际承包商榜单。中国对外承包工程商会新闻发言人张湘告诉记者,我国内地共有52家企业上榜。其中江苏南通六建集团有限公司等7家公司为新上榜企业,上榜企业比去年增加2家。但多项数据显示,国内企业对外承包业务运作水平与国际一流企业相比还存在很大差距。

  14. Hemispherical total emissivity and specific heat capacity of deeply undercooled Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 melts

    International Nuclear Information System (INIS)

    High-temperature high-vacuum electrostatic levitation (HTHVESL) and differential scanning calorimetry (DSC) were combined to determine the hemispherical total emissivity εT, and the specific heat capacity cp, of the undercooled liquid and throughout the glass transition of the Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 bulk metallic glass forming alloy. The ratio of cp/εT as a function of undercooling was determining from radiative cooling curves measured in the HTHVESL. Using specific heat capacity data obtained by DSC investigations close to the glass transition and above the melting point, εT and cp were separated and the specific heat capacity of the whole undercooled liquid region was determined. Furthermore, the hemispherical total emissivity of the liquid was found to be about 0.22 at 980 K. On undercooling the liquid, the emissivity decreases to approximately 0.18 at about 670 K, where the undercooled liquid starts to freeze to a glass. No significant changes of the emissivity are observed as the alloy undergoes the glass transition. copyright 1995 American Institute of Physics

  15. Crystallization and soft magnetic properties of rapidly solidified Fe73.5Nb3Cu1Si22.5-XBX (X=5, 9, 10, 11.25, 19) alloys

    International Nuclear Information System (INIS)

    The metalloids Si and B in the melt-spun Fe73.5Nb3Cu1Si22.5-XBX (X=5, 9, 10, 11.25, 19) alloys play a major role in their crystallization and magnetic behaviour. In the present work, the effect of nanocrystallization on the transport properties was studied using thermal variation of electrical resistivity. An X-ray diffractogram study showed that the formation of different phases was controlled by the metalloid content in the alloy. Nanocrystalline α-Fe(Si) and/or Fe3Si particles were formed in all the measured alloys except the alloy with 19 at% boron where α-Fe phase appeared. The lattice parameter as well as Si content within α-Fe(Si) was also found to depend on the metalloid content of the alloy. The Debye temperature was derived from thermal electrical resistivity study and was found to depend on the metalloid content of the alloys. However, Curie temperature of these alloys was not strongly dependent on the metalloid. The formation of α-Fe(Si) and/or Fe3Si nanoparticles was responsible for the superior soft magnetic properties of the 9 at% boron alloy annealed around 800 K. The early appearance of boride phases, which have high magnetocrystalline anisotropy, was the cause of deterioration in soft magnetic properties in X=5, 10, 11.25 and 19 alloys

  16. Homogeneous Plastic Flow of Fully Amorphous and Partially Crystallized Zr41.2Ti13.8Cu12.5Ni10Be22.5 Bulk Metallic Glass

    Institute of Scientific and Technical Information of China (English)

    Q.WANG; J.J. Blandin; M. Suery; B. Van de Moortéle; J.M. Pelletier

    2003-01-01

    The homogeneous plastic flow of fully amorphous and partially crystallized Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass (Vit1) has been investigated by compression tests at high temperatures in supercooled liquid region. Experimental results show that at sufficiently low strain rates, the supercooled liquid of the fully amorphous alloy reveals Newtonian flow with a linear relationship between the flow stress and strain rate. As the strain rate is increased, a transition from linear Newtonian to nonlinear flow is detected, which can be explained by the transition state theory.Over the entire strain rate interval investigated, however, only nonlinear flow is present in the partially crystallized alloy, and the flow stress for each strain rate is much higher. It is found that the strain rate-stress relationship for the partially crystallized alloy at the given temperature of 646 K also obeys the sinh law derived from the transition state theory, similar to that of the initial homogeneous amorphous alloy. Thus, it is proposed that the flow behavior of the nanocrystalline/amorphous composite at 646 K is mainly controlled by the viscous flow of the remaining supercooled liquid.

  17. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  18. Carbon Dioxide, Hydrographic, and Chemical Data Obtained During the R/V Meteor Cruise 22/5 in the South Atlantic Ocean (WOCE Section A10, December 1992-January 1993)

    Energy Technology Data Exchange (ETDEWEB)

    Kozyr, A.

    1998-12-01

    This data documentation discusses the procedures and methods used to measure total carbon dioxide (TCO{sub 2}) and total alkalinity (TALK) at hydrographic stations, as well as the underway partial pressure of CO{sub 2} (pCO{sub 2}) during the R/V Meteor Cruise 22/5 in the South Atlantic Ocean (Section A10). Conducted as part of the World Ocean Circulation Experiment (WOCE), the cruise began in Rio de Janeiro on December 27, 1992, and ended after 36 days at sea in Capetown, South Africa, on January 31, 1993. Measurements made along WOCE Section A10 included pressure, temperature, and salinity [measured by conductivity, temperature, and depth (CTD) sensor], bottle salinity, bottle oxygen, phosphate, nitrate, nitrite, silicate, chlorofluorocarbons (CFC-1 1 , CFC-12), TCO{sub 2}, TALK, and underway pCO{sub 2}. The TCO{sub 2} was measured by using two Single-Operator Multiparameter Metabolic Analyzers (SOMMAs) for extracting CO{sub 2} from seawater samples that were coupled to a coulometer for detection of the extracted CO{sub 2}. The overall precision and accuracy of the analyses was {+-} 1.9 {micro}mol/kg. Samples collected for TALK were measured by potentiometric titration; precision was {+-}2.0 {micro}mol/kg. Underway pCO{sub 2} was measured by infrared photometry with a precision of {+-} 2.0 {micro}atm. The work aboard the R/V Meteor was supported by the U.S. Department of Energy under contract DE-AC02-76CHOO016, and the Bundesministerium fir Forschung und Technologies through grants 03F0545A and MPG 099/1.

  19. THE FIRST Hi-GAL OBSERVATIONS OF THE OUTER GALAXY: A LOOK AT STAR FORMATION IN THE THIRD GALACTIC QUADRANT IN THE LONGITUDE RANGE 216. Degree-Sign 5 {approx}< l {approx}< 225. Degree-Sign 5

    Energy Technology Data Exchange (ETDEWEB)

    Elia, D.; Molinari, S.; Schisano, E.; Pestalozzi, M.; Benedettini, M.; Di Giorgio, A. M.; Pezzuto, S.; Rygl, K. L. J. [Istituto di Astrofisica e Planetologia Spaziali-INAF, Via Fosso del Cavaliere 100, I-00133 Roma (Italy); Fukui, Y.; Hayakawa, T.; Yamamoto, H. [Department of Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602 (Japan); Olmi, L. [Osservatorio Astrofisico di Arcetri-INAF, Largo E. Fermi 5, I-50125 Firenze (Italy); Veneziani, M. [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Schneider, N.; Piazzo, L. [IRFU/SAp CEA/DSM, Laboratoire AIM CNRS, Universit Paris Diderot, F-91191 Gif-sur-Yvette (France); Ikhenaode, D. [DIET-Dipartimento di Ingegneria dell' Informazione, Elettronica e Telecomunicazioni, Universita di Roma La Sapienza, via Eudossina 18, I-00184 Roma (Italy); Mizuno, A. [Solar-Terrestrial Environment Laboratory, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Onishi, T. [Department of Physical Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan); Polychroni, D. [Department of Astrophysics, Astronomy and Mechanics, Faculty of Physics, University of Athens, Panepistimiopolis, 15784 Zografos, Athens (Greece); Maruccia, Y., E-mail: davide.elia@iaps.inaf.it [Dipartimento di Matematica e Fisica, Universita del Salento, CP 193, I-73100 Lecce (Italy)

    2013-07-20

    We present the first Herschel PACS and SPIRE photometric observations in a portion of the outer Galaxy (216. Degree-Sign 5 {approx}< l {approx}< 225. Degree-Sign 5 and -2 Degree-Sign {approx}< b {approx}< 0 Degree-Sign ) as a part of the Hi-GAL survey. The maps between 70 and 500 {mu}m, the derived column density and temperature maps, and the compact source catalog are presented. NANTEN CO(1-0) line observations are used to derive cloud kinematics and distances so that we can estimate distance-dependent physical parameters of the compact sources (cores and clumps) having a reliable spectral energy distribution that we separate into 255 proto-stellar and 688 starless sources. Both typologies are found in association with all the distance components observed in the field, up to {approx}5.8 kpc, testifying to the presence of star formation beyond the Perseus arm at these longitudes. Selecting the starless gravitationally bound sources, we identify 590 pre-stellar candidates. Several sources of both proto- and pre-stellar nature are found to exceed the minimum requirement for being compatible with massive star formation based on the mass-radius relation. For the pre-stellar sources belonging to the Local arm (d {approx}< 1.5 kpc) we study the mass function whose high-mass end shows a power law N(log M){proportional_to}M {sup -1.0{+-}0.2}. Finally, we use a luminosity versus mass diagram to infer the evolutionary status of the sources, finding that most of the proto-stellar sources are in the early accretion phase (with some cases compatible with a Class I stage), while for pre-stellar sources, in general, accretion has not yet started.

  20. Continuous gradient temperature Raman spectroscopy of the long chain polyunsaturated fatty acids docosapentaenoic (DPA, 22:5n-6) and docosahexaenoic (DHA; 22:6n-3) from -100 to 20° C

    Science.gov (United States)

    Broadhurst, C. Leigh; Schmidt, Walter F.; Kim, Moon S.; Nguyen, Julie K.; Qin, Jianwei; Chao, Kuanglin; Bauchan, Gary L.; Shelton, Daniel R.

    2016-05-01

    The structural, cognitive and visual development of the human brain and retina strictly require long-chain polyunsaturated fatty acids (LC-PUFA). Excluding water, the mammalian brain is about 60% lipid. One of the great unanswered questions with respect to biological science in general is the absolute necessity of the LC-PUFA docosahexaenoic acid (DHA; 22:6n-3) in these fast signal processing tissues. A lipid of the same chain length with just one less diene group, docosapentaenoic acid (DPA; 22:5n-6) is fairly abundant in terrestrial food chains yet cannot substitute for DHA. Gradient Temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions. Herein we apply GTRS to DPA, and DHA from -100 to 20°C. 20 Mb three-dimensional data arrays with 1°C increments and first/second derivatives allows complete assignment of solid, liquid and transition state vibrational modes, including low intensity/frequency vibrations that cannot be readily analyzed with conventional Raman. DPA and DHA show significant spectral changes with premelting (-33 and -60°C, respectively) and melting (-27 and -44°C, respectively). The CH2-(HC=CH)-CH2 moieties are not identical in the second half of the DHA and DPA structures. The DHA molecule contains major CH2 twisting (1265 cm-1) with no noticeable CH2 bending, consistent with a flat helical structure with small pitch. Further modeling of neuronal membrane phospholipids must take into account this structure for DHA, which would be configured parallel to the hydrophilic head group line.

  1. 21 CFR 556.225 - Doramectin.

    Science.gov (United States)

    2010-04-01

    ... tissue) and of 30 parts per billion for parent doramectin in muscle. (2) Swine. A tolerance is established for parent doramectin (marker residue) in liver (target tissue) of 160 parts per billion....

  2. 12 CFR 225.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    .... (i) On a consolidated basis, the bank holding company maintains a total risk-based capital ratio of... bank holding company maintains a Tier 1 risk-based capital ratio of 6.0 percent or greater, as defined... capitalized under the capital adequacy regulations or guidelines applicable to the institution that have...

  3. 12 CFR 225.4 - Corporate practices.

    Science.gov (United States)

    2010-01-01

    ... consolidated assets of $500 million or more, consolidated pro forma risk-based capital and leverage ratio... Capital Adequacy Guidelines (appendix A of this part) and the Board's Policy Statement for Small Bank...'s Rules of Practice for Formal Hearings (12 CFR part 263). (iii) At the conclusion of the...

  4. 12 CFR 225.71 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Notice of Addition or Change of Directors.... (b) Regulated institution means a state member bank or a bank holding company. (c) Senior executive... Bank Holding Company Rating System; (2) Is subject to a cease-and-desist order or formal...

  5. 49 CFR 225.5 - Definitions.

    Science.gov (United States)

    2010-10-01

    ...) Any collision, derailment, fire, explosion, act of God, or other event involving operation of railroad... aggravation of a pre-existing injury or illness: (i) Death to any person; (ii) Injury to any person that... location where work assignments are initially made and oversight responsibility exists, e.g.,...

  6. 25 CFR 225.30 - Bonds.

    Science.gov (United States)

    2010-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS... Circular No. 570). (b) An operator may file a $75,000 bond for all geothermal, mining, or oil and gas... operator may file a $150,000 bond for full nationwide coverage to cover all geothermal or oil and...

  7. 48 CFR 225.7003-3 - Exceptions.

    Science.gov (United States)

    2010-10-01

    ... requests to the Under Secretary of Defense (Acquisition, Technology, and Logistics) (USD(AT&L)) for a... specialty metal, in the required form, for use in the production of fasteners for sale to DoD and...

  8. 7 CFR 225.17 - Procurement standards.

    Science.gov (United States)

    2010-01-01

    ... Procurement standards. (a) State agencies and sponsors shall comply with the requirements of 7 CFR part 3016 or 7 CFR part 3019, as applicable, concerning the procurement of supplies, food, equipment and other...) Procurements by public sponsors comply with applicable State or local laws and the standards set forth in 7...

  9. 29 CFR 779.225 - Leased departments.

    Science.gov (United States)

    2010-07-01

    ... enterprise includes “departments of an establishment operated through leasing arrangements.” This statutory... RETAILERS OF GOODS OR SERVICES Employment to Which the Act May Apply; Enterprise Coverage Leased Departments...'s other activities in such a way as to constitute a single enterprise under the Act. (c) Since...

  10. 49 CFR 192.225 - Welding procedures.

    Science.gov (United States)

    2010-10-01

    ... qualified under section 5 of API 1104 (incorporated by reference, see § 192.7) or section IX of the ASME... § 192.7) to produce welds meeting the requirements of this subpart. The quality of the test welds...

  11. 25 CFR 225.37 - Penalties.

    Science.gov (United States)

    2010-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS OIL AND GAS, GEOTHERMAL, AND SOLID MINERALS... Area Director whose findings shall be conclusive, unless an appeal is taken pursuant to 25 CFR part 2... the operator to late payment charges. Late payment charges shall be calculated on the basis of...

  12. 48 CFR 225.7003-1 - Definitions.

    Science.gov (United States)

    2010-10-01

    ...) Automotive item— (1) Means a self-propelled military transport tactical vehicle, primarily intended for use by military personnel or for carrying cargo, such as— (i) A high-mobility multipurpose wheeled...) Assembly, commercial derivative military article, commercially available off-the-shelf item,...

  13. 49 CFR 571.225 - Standard No. 225; Child restraint anchorage systems.

    Science.gov (United States)

    2010-10-01

    ...) and (b) of S7 apply to the test procedures in S8. (a) Vehicle seats are adjusted to their full... systems. S1. Purpose and scope. This standard establishes requirements for child restraint anchorage... buses, and funeral coaches. S3. Definitions. Child restraint anchorage means any vehicle...

  14. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization.

    Directory of Open Access Journals (Sweden)

    Jaspreet Singh Jaggi

    Full Text Available BACKGROUND: Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen and drug delivery and results in radiotherapy and chemotherapy resistance, respectively. Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature. METHODOLOGY AND PRINCIPAL FINDINGS: Actinium-225 ((225Ac-E4G10, an alpha-emitting antibody construct reactive with the unengaged form of vascular endothelial cadherin, is capable of potent, selective killing of tumor neovascular endothelium and late endothelial progenitors in bone-marrow and blood. No specific normal-tissue uptake of E4G10 was seen by imaging or post-mortem biodistribution studies in mice. In a mouse-model of prostatic carcinoma, (225Ac-E4G10 treatment resulted in inhibition of tumor growth, lower serum prostate specific antigen level and markedly prolonged survival, which was further enhanced by subsequent administration of paclitaxel. Immunohistochemistry revealed lower vessel density and enhanced tumor cell apoptosis in (225Ac-E4G10 treated tumors. Additionally, the residual tumor vasculature appeared normalized as evident by enhanced pericyte coverage following (225Ac-E4G10 therapy. However, no toxicity was observed in vascularized normal organs following (225Ac-E4G10 therapy. CONCLUSIONS: The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy.

  15. 385/65R22.520PR无内胎宽基全钢载重子午线轮胎的设计%Design of 385/65R22.5 20PR Wide Base Tubeless TBR Tire

    Institute of Scientific and Technical Information of China (English)

    王桂阳; 孙文文; 李心尚; 蒋林

    2015-01-01

    介绍385/65R22.520PR无内胎宽基全钢载重子午线轮胎的设计。结构设计:外直径1068 mm,断面宽度390 mm,行驶面宽度286 mm,行驶面弧度高10.2 mm,胎圈着合直径569.5 mm,胎圈着合宽度324 mm,断面水平轴位置0.8566,胎面花纹采用纵向主沟与横向细沟结合及变节距结构,花纹饱和度72.6%。施工设计:胎冠采用两方两块结构,胎侧采用三复合结构,胎体采用0.25+6+12×0.225HT钢丝帘线,1#与2#带束层均采用3+8×0.33HT钢丝帘线,3#和0°带束层分别采用3×4×0.22HE和3+9×0.22+0.15HT钢丝帘线,钢丝圈采用斜六角形结构;采用一次法成型机成型,双模硫化机氮气硫化。成品轮胎外缘尺寸、强度性能和耐久性能均符合相应设计和国家标准要求。%This paper introduces a design of 385/65R22.5 20PR wide base tubeless TBR tire. In the structure design, the following parameters were taken: overall diameter 1068 mm, cross-sectional width 390 mm, width of running surface 286 mm, arc height of running surface 10.2 mm, bead diameter at rim seat 569.5 mm, bead width at rim seat 324 mm, maximum width position of cross section 0.8566, tread pattern with main longitudinal grooves and small transverse grooves, variable pitch design, and block/total ratio 72.6. In the construction design, two formula and two piece structure was applied for tire crown, tri-layer composite structure was selected for the sidewall, 0.25+6+12×0.225HT steel cord was adopted in the carcass ply, 3+8×0.33HT steel cord was used in 1# and 2# belt layers, 3×4×0.22HE and 3+9×0.22+0.15HT steel cord were applied in the 3# and 0 ° belt layers, respectively, and hexagonal bead wire structure was used in the tire bead. The tire was built on single stage building machine and then cured on curing press under nitrogen. It was conifrmed by the test of the ifnished tires that the inlfated peripheral dimension, strength performance and endurance performance

  16. (abstract) Determination of the Specific Heat and Total Hemispherical Total Emissivity of the Highly Undercooled Zr(sub 41.2)Ti(sub 13.8)Cu(sub 12.5)Ni(sub 10.0)Be(sub 22.5) Alloy

    Science.gov (United States)

    Busch, R.; Kim, Y. J.; Johnson, W. L.; Rulison, A. J.; Rhim, W. K.

    1995-01-01

    High temperature high vacuum electrostatic levitation was combined with DSC experiments to determine the specific heat C(sub p) of the undercooled Zr(sub 41.2)Ti(sub 13.8)Cu(sub 12.5)Ni(sub 10.0)Be(sub 22.5) liquid as a function of temperature. The containerless approach made it possible to undercool the melt to the glass transition temperature without inducing nucleation. Because the cooling process was purely radiative, noncontact temperature measurement techniques could be used to determine the specific heat to total hemispherical emissivity ratio, C(sub p)/epsilon(sub t), for the undercooled liquid region. Using C(sub p) values which were independently obtained by DSC, epsilon(sub t) could be determined. With knowledge of C(sub p) of the undercooled liquid it was possible to determine other thermodynamic properties such as Gibbs free energy and entropy as a function of undercooling.

  17. Mitotic effects of monochromatic ultraviolet radiation at 225, 265, and 280 nm on eleven stages of the cell cycle of the grasshopper neuroblast in culture. II. Changes in progression rate and cell sequence between the stage irradiated and nuclear membrane breakdown

    International Nuclear Information System (INIS)

    Portions of embryos of the grasshopper, Chortophaga viridifasciata (DeGeer), were cultured in hanging drops under quartz cover slips. Immediately after exposure to 225, 265, or 280 nm radiation, microscope observations at 380C were begun. The morphologically identified stage and the time after treatment of selected neuroblasts were recorded at short-time intervals until prometaphase was reached. Mitotic retardation induced by irradiation of prereplication stages (metaphase, anaphase, or early telophase) or S phase (middle or late telophase, interphase, or very early prophase) is greatest in postreplication stages (early, middle, and late prophase) and absent or minimal in stages morphologically identified as parts of S phase. Ultraviolet irradiation superimposes on the normal diversity of progression rates an additional variation factor, so that cells do not necessarily reach prometaphase in the order of their sequence at the time of treatment. This suggests the need for caution in ascribing particular radiosensitivities to substages of limited duration on the basis of the order in which they attain a subsequent stage

  18. 20 CFR 702.225 - Withdrawal of a claim.

    Science.gov (United States)

    2010-04-01

    ... HARBOR WORKERS' COMPENSATION ACT AND RELATED STATUTES ADMINISTRATION AND PROCEDURE Claims Procedures... request for withdrawal is approved, such withdrawal shall be without prejudice to the filing of another claim, subject to the time limitation provisions of section 13 of the Act and of the regulations in...

  19. 14 CFR 125.225 - Flight data recorders.

    Science.gov (United States)

    2010-01-01

    ... recording intervals specified in appendix D of this part: (1) Time; (2) Altitude; (3) Airspeed; (4) Vertical...) Vertical acceleration; (5) Heading; (6) Time of each radio transmission either to or from air traffic... airplane equipped with a digital data bus and ARINC 717 digital flight data acquisition unit (DFDAU)...

  20. Dicty_cDB: VHE225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available miliaris genomic,genomic survey sequence. 40 0.058 2 EK225313 |EK225313.1 1095460156784 Global-Ocean-Samplin...g_GS-31-01-01-1P3-1P8KB marine metagenome genomic clone 1061005707342 3', genomic survey... fsbb001f209i23k0 Sorghum methylation filtered library (LibID: 104) Sorghum bicolor genomic clone fsbb001f209i23, genomic survey...ibrary (LibID: 104) Sorghum bicolor genomic clone fsbb001f208d23, genomic survey ...orghum bicolor genomic clone fsbb001f137c21, genomic survey sequence. 46 1.1 1 CL168450 |CL168450.1 104_366_

  1. 47 CFR 76.225 - Commercial limits in children's programs.

    Science.gov (United States)

    2010-10-01

    ... purposes, including either e-commerce or advertising; (3) The Web site's home page and other menu pages are... site to which viewers are directed by the Web site address is not used for e-commerce, advertising, or other commercial purposes (e.g., contains no links labeled “store” and no links to another page...

  2. Dicty_cDB: AFN225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available *insmmnnnnnhkkfqin nnfknnklihprifnin*ii*inhskmtiimiklkn*kmmiiilminkltmvnlkimlkn fli*MMLMIILNKLTTTTTTSIIITITT...nnnhkkfqin nnfknnklihprifnin*ii*inhskmtiimiklkn*kmmiiilminkltmvnlkimlkn fli*MMLMIILNKLTTTTTTSIIITITTLKLINQRK

  3. 12 CFR 225.66 - Professional association membership; competency.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Professional association membership; competency...; competency. (a) Membership in appraisal organizations. A State certified appraiser or a State licensed...) Competency. All staff and fee appraisers performing appraisals in connection with federally...

  4. 7 CFR 225.11 - Corrective action procedures.

    Science.gov (United States)

    2010-01-01

    ... suspected fraud or criminal abuse in the Program which would result in a loss or misuse of Federal funds... through its corporate organization, officers, employees, or otherwise, as an institution...

  5. 48 CFR 1852.225-70 - Export Licenses.

    Science.gov (United States)

    2010-10-01

    ..., including the International Traffic in Arms Regulations (ITAR), 22 CFR parts 120-130, and the Export Administration Regulations (EAR), 15 CFR parts 730-799, in the performance of this contract. In the absence of... exemption at 22 CFR 125.4(b)(3). The Contracting Officer or designated representative may authorize...

  6. 40 CFR 180.225 - Phosphine; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    .... Commodity Parts per million Almond 0.1 Avocado 0.01 Banana 0.01 Barley, grain 0.1 Cabbage, Chinese, bok choy..., bean, green 0.1 Corn, field, grain 0.1 Corn, pop, grain 0.1 Cotton, undelinted seed 0.1 Date, dried fruit 0.1 Dill, seed 0.01 Eggplant 0.01 Endive 0.01 Grapefruit 0.01 Hazelnut 0.1 Kumquat 0.01 Lemon...

  7. 12 CFR 225.12 - Transactions not requiring Board approval.

    Science.gov (United States)

    2010-01-01

    ... Capital Adequacy Guidelines (appendices A, B, C, D, and E of this part); (v) At least 10 days prior to the... Board's Capital Adequacy Guidelines (appendices A, B, C, D, and E of this part). (e) Holding...

  8. 12 CFR 225.1 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ...)). (11) Appendix A to the regulation contains the Board's Risk-Based Capital Adequacy Guidelines for bank holding companies. (12) Appendix B contains the Board's Capital Adequacy Guidelines for measuring leverage... statement governing small bank holding companies. (14) Appendix D contains the Board's Capital...

  9. 12 CFR 225.42 - Transactions not requiring prior notice.

    Science.gov (United States)

    2010-01-01

    ... RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Change in Bank... acquisition of additional voting securities of a state member bank or bank holding company by a person who: (i... class of voting securities of a state member bank or bank holding company by any person (or...

  10. 7 CFR 225.6 - State agency responsibilities.

    Science.gov (United States)

    2010-01-01

    ... nonprofit organization to operate more than 25 sites. In addition, the State agency must not approve any private nonprofit organization to serve more than 300 children at any one site for any approved meal... organization must demonstrate that it is fully capable of managing a site with more than 300 children and...

  11. 48 CFR 225.7703-4 - Reporting requirement.

    Science.gov (United States)

    2010-10-01

    ... reports to the Deputy Director, Contingency Contracting & Acquisition Policy, Defense Procurement and... Navy. (d) The Department of the Air Force. (e) The Defense Logistics Agency. (f) The other...

  12. 7 CFR 225.16 - Meal service requirements.

    Science.gov (United States)

    2010-01-01

    ...) Lean meat or poultry or fish or 1 ounce. Alternate protein product 6 or 1 ounce. Cheese or 1 ounce. Egg (large) or 1/2. Cooked dry beans or peas or 1/4 cup. Peanut butter or an equivalent quantity of any combination of meat/meat alternate or 2 tablespoons. Yogurt, plain or flavored, unsweetened or sweetened...

  13. 48 CFR 252.225-7013 - Duty-free entry.

    Science.gov (United States)

    2010-10-01

    ...) Scrap or salvage; or (ii) Competitive sale made, directed, or authorized by the Contracting Officer. (d... shipment under 19 CFR part 142 and notify Commander, Defense Contract Management Agency (DCMA) New York... Contractor's name, address, and Commercial and Government Entity (CAGE) code; (2) Prime contract number...

  14. 48 CFR 252.225-7021 - Trade agreements.

    Science.gov (United States)

    2010-10-01

    ...)). These exclusions presently consist of— (A) Textiles, apparel articles, footwear, handbags, luggage, flat..., Belgium, Bulgaria, Canada, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany,...

  15. Dicty_cDB: VSD225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available skitlvlcviqkvkskvtfsdq sprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---VYINNVKSTSRR**lqsi...*lsdkentgrermvftsiskitlvlcviqkvkskvtfsdq sprnapiygqrlppmpvplfk*IHIKLKQYKKK--- ---...iqkvkskvtf sdqsprnapiygqrlppmpvplfk*ihiklkq Homology vs CSM-cDNA Score E Sequences producing significant ali

  16. 6 CFR 27.225 - Site security plans.

    Science.gov (United States)

    2010-01-01

    ... Vulnerability Assessment, and identify and describe the security measures to address each such vulnerability; (2) Identify and describe how security measures selected by the facility will address the applicable risk-based... updates, revises or otherwise alters its Security Vulnerability Assessment pursuant to § 27.215(d),...

  17. 48 CFR 225.7300 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... military sales (FMS) under the Arms Export Control Act (22 U.S.C. Chapter 39). Section 22 of the Arms Export Control Act (22 U.S.C. 2762) authorizes DoD to enter into contracts for resale to foreign... under DoD cooperative logistic supply support arrangements....

  18. 5 CFR 532.225 - Nonappropriated fund survey jobs.

    Science.gov (United States)

    2010-01-01

    ... agency shall survey the following required jobs: Job title Job grade Janitor (Light) 1 Food Service Worker 1 Food Service Worker 2 Fast Food Worker 2 Janitor 2 Laborer (Light) 2 Laborer (Heavy) 3 Service... Warehouseman 5 Service Station Attendant 5 Truck Driver (Light) 5 Truck Driver (Medium) 6 Truck Driver...

  19. Dicty_cDB: AFO225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ) Danio rerio gelsolin mRNA, complet... 96 1e-18 BC125898_1( BC125898 |pid:none) Danio rerio scinderin like ...1( BC155581 |pid:none) Danio rerio scinderin like a, mRNA... 95 4e-18 protein update 2009. 4.26 PSORT psg: 0

  20. 40 CFR 265.225 - Waste analysis and trial tests.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND... the different process: (i) Conduct waste analyses and trial treatment tests (e.g., bench scale or... waste under similar operating conditions; to show that this treatment will comply with § 265.17(b). (b)...

  1. 50 CFR 600.225 - Rules of conduct.

    Science.gov (United States)

    2010-10-01

    ... Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... are responsible for maintaining high standards of ethical conduct among themselves, their staffs, and...) Council members, employees, and contractors must comply with the Federal Cost Principles Applicable...

  2. 7 CFR 225.9 - Program assistance to sponsors.

    Science.gov (United States)

    2010-01-01

    ... changes in the series for food away from home of the Consumer Price Index(CPI) for all urban consumers... sponsors information on available commodities. Sponsors shall use in the Program food donated by the... Program, and operate more than one child nutrition program under a single State agency, must use a...

  3. Epoxy injection repairs to concrete in 225-B Building

    Energy Technology Data Exchange (ETDEWEB)

    Vollert, F.R.

    1996-09-19

    In 1982, the damaged anchor areas (67 total) in the Operating Gallery and cold manipulator shop ceiling reinforced concrete slabs were epoxy injection repaired by Construction Technology Laboratories (CTL), Portland Cement Association. The through depth vertical cracks (10 total) in the ceiling slabs in the galleries and manipulator shops were sealed and structurally repaired using epoxy injection procedures. The details of the epoxy reRair are reported. Sonic nondestructive (NDT) testing before and after the epoxy injection repairs were made by CTL to confirm that the repairs are structurally effective. CTL recommended to expedite the installation of lateral bracing for the manipulator monorail in order to avoid re-darnage to the repaired anchor areas.

  4. 20 CFR 627.225 - Employment generating activities.

    Science.gov (United States)

    2010-04-01

    ... decisions about community job training needs; subscriptions to relevant publications; general dissemination... businesses, investment in contract bidding resource centers, or similar activities. (2) No funds available... employer outreach and job development activities including, but not limited to: contacts with...

  5. 7 CFR 225.15 - Management responsibilities of sponsors.

    Science.gov (United States)

    2010-01-01

    ...) Examples of income that should be provided on the application, including: Earnings, wages, welfare benefits... specify a minimum price; (v) The invitation to bid contains a cycle menu approved by the State agency...

  6. 25 CFR 225.1 - Purpose and scope.

    Science.gov (United States)

    2010-04-01

    ... the Indian mineral owners believe will maximize their best economic interest and minimize any adverse... to provide reasonable provisions satisfactorily addressing the issues of valuation, method of...

  7. Dicty_cDB: SLF225 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available * ilnyneiiffqfskkkkkkkkkkkkkkkkk Frame C: *qfys*fwl*fqsxmlntnshhhlkihhqmiqiak*lvhnhtl--- ---wyfrrfwfrfrfrfrlr*rfrfrfrccqwftir...frccqwftirfrcc*wftiwcpnw ftircw*cfrcfhw*piwfsisrn*ywfiiqw*w*wcpn

  8. Metal hydrogen sulfide critical temperature at the pressure 225 gpa

    OpenAIRE

    Kudryashov, Nikolay; Kutukov, Alexander; Mazur, Evgeny

    2016-01-01

    \\'Eliashberg theory, being generalized to the electron-phonon (EP) systems with not constant density of electronic states, as well as to the frequency behavior of the renormalization of both the electron mass and the chemical potential, is used to study hydrogen sulphide phase under pressure. The phonon contribution to the anomalous electron Green's function (GF) is considered. The pairing is considered within the overall width of the electron band, and not only in a narrow layer at the Fermi...

  9. 7 CFR 2.25 - Assistant Secretary for Civil Rights.

    Science.gov (United States)

    2010-01-01

    ... Justice on matters relating to title VI of the Civil Rights Act of 1964 (42 U.S.C. 2000d), title IX of the..., and 15d of this title, except in those cases where the Assistant Secretary for Civil Rights has... substantial minority group enrollment in Departmental programs and activities. (17) Related to...

  10. 2.25 Cr-1 Mo-0.25 V钢焊材用Gleeble再热裂纹试验参数研究%Research on Gleeble Reheating Cracking Test Parameters for 2.25 Cr-1 Mo-0.25 V Steel Weld Material

    Institute of Scientific and Technical Information of China (English)

    钱俊锋; 陈学东; 卜华全

    2015-01-01

    2008年以来,为防止钒改进钢(2.25Cr-1Mo-0.25V)制加氢反应器出现再热裂纹,钒改进钢焊接材料均采用Gleeble再热裂纹试验确定焊缝金属的韧性储备。为研究Gleeble再热裂纹试验中的部分试验参数对试验结果的影响,对由钒改进钢制成的Gleeble试样进行一次焊接热循环模拟获取热影响区组织后,在不同参数值下进行Gleeble再热裂纹对比试验。试验结果表明,试样取样位置对试验结果影响较小,应变速率的变化对试验结果影响很大,保温时间在达到10 min之后对试验结果基本没有影响,为合理选择Gleeble再热裂纹试验参数提供了依据。%To prevent the occurrence of reheat cracking in the vanadium modified steel (2.25Cr-1Mo-0.25V)heavy reactors fabrication,all vanadium modified steel welding materials have to be determined the toughness of weld metal by using gleeble reheat cracking(GRC)test from 2008.To study the influ-ence of some test parameters on the result,the vanadium modified steel specimens should be done the welding thermal cycle simulation test to get a simulated heat affected zone(HAZ)and then done GRC test in different parameter values.The experimental results implies the sampling location has litter effect and the strain rate has great effect on the test results,and the soaking duration has litter effect until the soa-king time reaches 10 min,which provide a basis for reasonable choice of parameters of GRC test.

  11. Interactions with ATP, DNA Cleavage and Anti-tumor Activities of Complexes with Anions [Mo(V)O2(O2CeH4)2]3-, [Mo(Ⅴ)0.5W(Ⅵ)0.5O2(O2C6H4)2]2.5- and [W(Ⅵ)O2(O2C6H4)2]2-

    Institute of Scientific and Technical Information of China (English)

    鲁晓明; 姜凌; 毛希安; 叶朝晖; 卢景芬; 崔景荣

    2005-01-01

    (NH3CH2CH2NH2)3[Mo(Ⅴ)O2(O2C6H4)2] (1), (NH3CH2CH2NH2)2.5[Mo(Ⅴ)o.sW(Ⅵ)o.502(O2C6H4)2] (2) and(NH3CH2CH2NH2)2[VC(Ⅵ)O2(O2C6H4)2] (3) were synthesized, structurally characterized by X-ray diffraction analysis, and studied on their interactions with ATP, their DNA cleavage activities and antitumor properties. The redox state of molybdenum was not changed on going from crystal to aqueous solutions in complexes 1 and 2, while tungsten underwent reduction from W(VI) to W(V) in complexes 2 and 3. ATP promoted the oxidation of both molybdenum and tungsten from M(Ⅴ) to M(Ⅵ) and the hydrolysis of catecholate ligands in solution consisting of ATP and the complexes. Complex 1 possesses fairly good activity to DNA cleavage and against tumor S180 in mice, and is more effective than the control drug cyclophosphamide under the identical conditions. However, complexes 2 and 3 exhibited marginal effectiveness. The effectiveness of anti-tumor of the complexes was related positively to their DNA cleavage activities and their hydrolysis of catecholate ligands.

  12. Study on laser atomic spectroscopy

    International Nuclear Information System (INIS)

    Laser atomic spectroscopic study on actinium element has been performed in many areas of spectroscopy. The study on characteristic of atomic vapor has been proceeded for copper atom and the spatial density distribution of copper vapor is measured. This experimental data has been compared with the theoretically calculated data. In spectroscopic experiment, the first and second excited states for actinium element are identified and the most efficient ionization scheme for actinium element is identified. In addition, the corrosion problem for filament material due to the heating of the actinium element has been studied. (Author)

  13. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    International Nuclear Information System (INIS)

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  14. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  15. A Critical Review of Alpha Radionuclide Therapy-How to Deal with Recoiling Daughters?

    Science.gov (United States)

    de Kruijff, Robin M; Wolterbeek, Hubert T; Denkova, Antonia G

    2015-01-01

    This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. PMID:26066613

  16. A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    Science.gov (United States)

    de Kruijff, Robin M.; Wolterbeek, Hubert T.; Denkova, Antonia G.

    2015-01-01

    This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue. PMID:26066613

  17. A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    Directory of Open Access Journals (Sweden)

    Robin M. de Kruijff

    2015-06-01

    Full Text Available This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET. Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium, 223Ra, and 225Ac (actinium can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue.

  18. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  19. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  20. Geochemistry of Precambrian carbonates. IV - Early Paleoproterozoic (2.25 +/- 0.25 Ga) seawater

    Science.gov (United States)

    Veizer, Jan; Clayton, R. N.; Hinton, R. W.

    1992-01-01

    The mineralogy, chemistry, and isotopic composition of the Malmani Dolomite, Duck Creek Dolomite, and Bruce 'Limestone' Member of the Espanola Formation are studied in an effort to restrict the first- and second-order variations in isotopic composition of Early Paleoproterozoic seawater. The diagenetic rank is found to increase in the order Duck Creek less than Bruce less than Malmani. The interpolation of alteration trends to 'best' value yields an estimate of 0.70550 for Sr-87/Sr-86. For delta C-13, the measured range of 0 +/- 1.5 percent PDB is similar to that observed for Phanerozoic marine carbonates, while the 'best' delta O-18 value for dolostones is -5 percent PDB, depleted in O-18 relative to Phanerozoic counterparts but comparable to estimates obtained for Archean facies. The isotope geochemistry and mineralogy of Bruce 'Limestone' Member is consistent with the proposition that the sequence was deposited in a lacustrine environment.

  1. 78 FR 55773 - Fourteenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    Science.gov (United States)

    2013-09-11

    ... Battery and Battery Systems--Small and Medium Size AGENCY: Federal Aviation Administration (FAA), U.S... Lithium Battery and Battery Systems--Small and Medium Size. SUMMARY: The FAA is issuing this notice to... Battery and Battery Systems--Small and Medium Size DATES: The meeting will be held October 1-3, 2013,...

  2. 12 CFR 225.101 - Bank holding company's subsidiary banks owning shares of nonbanking companies.

    Science.gov (United States)

    2010-01-01

    ...) apply to the aggregate amount of stock held in a particular organization by the bank holding company... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company's subsidiary banks owning... company's subsidiary banks owning shares of nonbanking companies. (a) The Board's opinion has...

  3. 12 CFR 225.13 - Factors considered in acting on bank acquisition proposals.

    Science.gov (United States)

    2010-01-01

    ... provided in § 211.24(c)(1)(ii) of the Board's Regulation K (12 CFR 211.24(c)(1)(ii)). (b) Other factors. In..., including the Board's Regulation BB (12 CFR part 228). (c) Interstate transactions. The Board may approve... future prospects, including whether current and projected capital positions and levels of...

  4. Biggest Pork Barrel Ever: $225-Million for Projects That Bypassed Merit Reviews.

    Science.gov (United States)

    Cordes, Colleen

    1988-01-01

    Congress has quietly approved millions of dollars for campus research projects not subjected to traditional merit reviews. The wisdom of allowing legislators to direct federal money to specific campuses is questioned less and less, and the practice is more prevalent than ever. (MSE)

  5. 7 CFR Appendix A to Part 225 - Alternate Foods for Meals

    Science.gov (United States)

    2010-01-01

    ... alternate protein product and on an as prepared basis. f. For an alternate protein product mix... Used in the Summer Food Service Program? 1. An alternate protein product used in meals planned under... product whether used alone or in combination with meat or other meat alternates must meet the...

  6. 49 CFR 173.225 - Packaging requirements and other provisions for organic peroxides.

    Science.gov (United States)

    2010-10-01

    ... separation; (ii) The sample must be packaged in accordance with packing method OP2, for a liquid or solid... and self-reactive substances are listed in the Maximum Quantity per Packing Method Table. The packing... mass percent, the minimum amount of water, if any, which must be in formulation. (6) Packing...

  7. 78 FR 38093 - Thirteenth Meeting: RTCA Special Committee 225, Rechargeable Lithium Battery and Battery Systems...

    Science.gov (United States)

    2013-06-25

    ... administrative items. Review agenda. Review and approval of summary from last Plenary meeting. Status of TOR and... FRAC comments. Create plan and schedule for updating DO-311 per updated TOR. Establish agenda for...

  8. 12 CFR 225.173 - How are investments in private equity funds treated under this subpart?

    Science.gov (United States)

    2010-01-01

    ...) Portfolio companies held through a private equity fund. A financial holding company may not routinely manage... is controlled by a financial holding company may not routinely manage or operate a portfolio company... holding company. A private equity fund may routinely manage or operate a portfolio company so long as...

  9. 49 CFR 225.19 - Primary groups of accidents/incidents.

    Science.gov (United States)

    2010-10-01

    ... equipment accidents/incidents are collisions, derailments, fires, explosions, acts of God, and other events... following outcomes, and this outcome is a new case or a significant aggravation of a pre-existing injury or... of Transportation (49 CFR 1.49(g) and (m)) Editorial Note: For Federal Register citations...

  10. 18 CFR 225.3 - Schedule of records and periods of retention.

    Science.gov (United States)

    2010-04-01

    ... contracts to which they relate. (d) Card or book records of contracts, leases, and agreements made that show... excluding deeds and leases but including such records as lease sheets, leasehold cards, and option... segregating the accumulated depreciation according to functional classification of plant 25 years. (b)...

  11. 48 CFR 225.401-70 - End products subject to trade agreements.

    Science.gov (United States)

    2010-10-01

    ... Engine accessories 30 Mechanical power transmission equipment 32 Woodworking machinery and equipment 34 Metalworking machinery 35 Service and trade equipment 36 Special industry machinery (except 3690)...

  12. 12 CFR 225.118 - Computer services for customers of subsidiary banks.

    Science.gov (United States)

    2010-01-01

    ... subsidiary banks. (a) The question has been presented to the Board of Governors whether a wholly-owned... will the service company provide services for anyone other than its affiliated banks. Moreover, it will not hold itself out as, nor will its parent corporation or affiliated banks represent it to...

  13. 12 CFR 225.138 - Statement of policy concerning divestitures by bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... divestiture period approaches the “forced sale” aspect of the divestiture may lead potential buyers to... be accomplished—for example, by a bulk sale of the assets to a third party, by “spinoff” or... sale by a specified date, by public auction if necessary. Such a trustee may be given...

  14. 49 CFR 40.225 - What form is used for an alcohol test?

    Science.gov (United States)

    2010-10-01

    ... colored paper, or have clearly discernable borders or designation statements on Copy 2 and Copy 3. When... foreign-language version of the ATF approved by ODAPC. You may use such a non-English language form only in a situation where both the employee and BAT/STT understand and can use the form in that language....

  15. A continuum damage analysis of hydrogen attack in 2.25 Cr-1Mo vessel

    DEFF Research Database (Denmark)

    van der Burg, M.W.D.; van der Giessen, E.; Tvergaard, Viggo

    1998-01-01

    A micromechanically based continuum damage model is presented to analyze the stress, temperature and hydrogen pressure dependent material degradation process termed hydrogen attack, inside a pressure vessel. Hydrogen attack (HA) is the damage process of grain boundary facets due to a chemical...... of the temperature, hydrogen pressure and applied stresses. The model is applied to study HA in a vessel wall, where nonuniform distributions of hydrogen pressure, temperature and stresses result in a nonuniform damage distribution over the vessel wall. Stresses inside the vessel wall first tend to accelerate...... and later decelerate the cavitation rate significantly. Numerical studies for different material parameters and different stress conditions demonstrate the HA process inside a vessel in time. Also, the lifetime of the pressure vessel is determined. The analyses underline that the general applicability...

  16. 12 CFR 225.200 - Conditions to Board's section 20 orders.

    Science.gov (United States)

    2010-01-01

    ... include observing corporate formalities (such as the maintenance of separate accounting and corporate...) Introduction. Under section 20 of the Glass-Steagall Act (12 U.S.C. 377) and section 4(c)(8) of the Bank... standard, the manager of a branch or agency of a foreign bank generally will be considered to be the...

  17. 12 CFR Appendix F to Part 225 - Interagency Guidelines Establishing Information Security Standards

    Science.gov (United States)

    2010-01-01

    ... restrictions at physical locations containing customer information, such as buildings, computer facilities, and... attacks on or intrusions into customer information systems; g. Response programs that specify actions to... Office of the Comptroller of the Currency (OCC), and the Office of Thrift Supervision (OTS). 2 12...

  18. 48 CFR 252.225-7012 - Preference for certain domestic commodities.

    Science.gov (United States)

    2010-10-01

    ..., the following are qualifying countries: Australia Austria Belgium Canada Denmark Egypt Finland France... thereof. Clothing includes items such as outerwear, headwear, underwear, nightwear, footwear,...

  19. 28 CFR 54.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-07-01

    ...) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE... section applies to each educational institution to which §§ 54.300 through 54.310 apply that: (1) Admitted... institution to which this section applies shall not discriminate on the basis of sex in admission...

  20. 14 CFR 1253.225 - Educational institutions eligible to submit transition plans.

    Science.gov (United States)

    2010-01-01

    ... ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL...) Application. This section applies to each educational institution to which §§ 1253.300 through 1253.310 apply... educational institution to which this section applies shall not discriminate on the basis of sex in...