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Sample records for actinium 217

  1. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  2. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  3. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  4. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Science.gov (United States)

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development.

  5. Relativistic small-core pseudopotentials for actinium, thorium, and protactinium.

    Science.gov (United States)

    Weigand, Anna; Cao, Xiaoyan; Hangele, Tim; Dolg, Michael

    2014-04-03

    Small-core pseudopotentials for actinium, thorium, and protactinium have been energy-adjusted to multiconfiguration Dirac-Hartree-Fock reference data based on the Dirac-Coulomb-Breit Hamiltonian and the Fermi nucleus model. Corresponding optimized valence basis sets of polarized valence quadruple-ζ quality are presented. Atomic test calculations for the first four ionization potentials show satisfactory results at both the Hartree-Fock and the multireference averaged coupled-pair functional level. Highly correlated Fock-space coupled cluster calculations demonstrate that the new pseudopotentials yield ionization potentials, which are in excellent agreement with corresponding all-electron results and experimental data. The pseudopotentials and basis sets supplement a similar set previously published for uranium.

  6. Effects of spin-orbit coupling on actinium under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Rubio-Ponce, A.; Rivera, J. [Departamento de Ciencias Basicas, Universidad Autonoma Metropolitana-Azcapotzalco, Mexico (Mexico); Olguin, D. [Departamento de Fi sica, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico (Mexico)

    2015-04-15

    Actinium (Ac) is a radioactive metal and the first element of the actinide series. At ambient conditions Ac crystallizes in the fcc lattice, however, up to date its phase diagram is unknown. In the present work, we have studied the structural and electronic properties of Ac under hydrostatic pressure assuming the fcc structure as well as three hypothetical structures, namely the hcp, bcc, and sc, and for pressures up to 100 GPa. From our calculations, we found only one structural transition allowed, from the fcc to hcp, our calculated pressure was 39.85 GPa. The calculations were performed by means of the full potential linearized augmented plane wave (FLAPW) method and the generalized gradient approximation (GGA) for the exchange-correlation energy, where we have included in our study the spin-orbit coupling which is important for heavy elements. The total energy results were fitted to the third order Birch-Murnaghan's equation of state. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  7. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  8. Report for General Research September 18 to December 11, 1950 (Actinium Volume)

    Energy Technology Data Exchange (ETDEWEB)

    Haring, M.M.

    1951-01-15

    The purpose of the research work presented in this volume is to develop a process for the separation and purification of actinium-227 produced by neutron bombardment of radium-226 and to develop methods by which uniform films of actinium metal may be deposited on metallic surfaces. The design work on the cave structure and mechanical equipment used in the actinium separation is proceeding on schedule. As the mechanical design phase is nearing completion the emphasis is being directed toward processing equipment. The process as well as the mechanical equipment has been adapted from the research work of F. T. Hagemann and the Remote Control Group at Argonne National Laboratory. Consequently, one of the first objectives is to become familiary with the chemistry of the process and the operation of the mechanical equipment. Cold runs have been made on the T.T.A. benzene extraction using lanthanum and barium in place of actinium and radium. No difficulty with the operation was observed. The formation of precipitates was one of the difficulties encountered with the process as the precipitates carry radium. It has been found that metals such as nickel cause these precipitates to form and should, therefore, be avoided in the construction of equipment. it was also found that a T.T.A. solution exposed to 0.5 curie of polonium over a period of days develops a precipitate. Some new mechanical features hav eshown promise. The use of copper-coated glassware which will hold together even though the glass is cracked has made it possible to replace custom-built heaters with standard heating mantles. A new graphite, silicone grease mixture appears to hold up in stopcocks handling benzene and, as a result, may eliminate the necessary of entering the cave for regreasing. Tests on the preparation of dense concrete have given results which meet the shielding requirements for the cave. A strippable paint and tape combination has been studied and specified to provide for decontamination of

  9. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  10. 45 CFR 150.217 - Preliminary determination.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Preliminary determination. 150.217 Section 150.217... Are Failing To Substantially Enforce HIPAA Requirements § 150.217 Preliminary determination. If, at... designees). (b) Notifies the State of CMS's preliminary determination that the State has failed to...

  11. 46 CFR 169.217 - Posting.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Posting. 169.217 Section 169.217 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.217 Posting. The certificate of inspection must be framed...

  12. 47 CFR 87.217 - Frequencies.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequencies. 87.217 Section 87.217... Aeronautical Advisory Stations (Unicoms) § 87.217 Frequencies. (a) Only one unicom frequency will be assigned at any one airport. Applicants must request a particular frequency, which will be taken...

  13. 7 CFR 1280.217 - Lamb purchases.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Lamb purchases. 1280.217 Section 1280.217 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Assessments § 1280.217 Lamb purchases....

  14. 49 CFR 238.217 - Side structure.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Side structure. 238.217 Section 238.217 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.217 Side structure. Each passenger car shall comply with the following: (a) Side posts...

  15. 33 CFR 136.217 - Compensation allowable.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Compensation allowable. 136.217 Section 136.217 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.217...

  16. 48 CFR 252.217-7010 - Performance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Performance. 252.217-7010... Clauses 252.217-7010 Performance. As prescribed in 217.7104(a), use the following clause: Performance (JUL..., scrap or other ship's material of the Government resulting from performance of the work as items...

  17. 22 CFR 217.4 - Discrimination prohibited.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discrimination prohibited. 217.4 Section 217.4... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 217.4 Discrimination... participation in, be denied the benefits of, or otherwise be subjected to discrimination under any program or...

  18. 14 CFR 217.7 - Certification.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Certification. 217.7 Section 217.7 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC... NONSCHEDULED SERVICES § 217.7 Certification. The certification for BTS Form 41 Schedule T-100(f) shall...

  19. 22 CFR 217.23 - New construction.

    Science.gov (United States)

    2010-04-01

    ... Uniform Federal Accessibility Standards (USAF) (appendix A to 41 CFR subpart 101-19.6) shall be deemed to... 22 Foreign Relations 1 2010-04-01 2010-04-01 false New construction. 217.23 Section 217.23 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Accessibility § 217.23 New construction. (a) Design...

  20. Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

    Science.gov (United States)

    Radchenko, V; Engle, J W; Wilson, J J; Maassen, J R; Nortier, F M; Taylor, W A; Birnbaum, E R; Hudston, L A; John, K D; Fassbender, M E

    2015-02-06

    Actinium-225 (t1/2=9.92d) is an α-emitting radionuclide with nuclear properties well-suited for use in targeted alpha therapy (TAT), a powerful treatment method for malignant tumors. Actinium-225 can also be utilized as a generator for (213)Bi (t1/2 45.6 min), which is another valuable candidate for TAT. Actinium-225 can be produced via proton irradiation of thorium metal; however, long-lived (227)Ac (t1/2=21.8a, 99% β(-), 1% α) is co-produced during this process and will impact the quality of the final product. Thus, accurate assays are needed to determine the (225)Ac/(227)Ac ratio, which is dependent on beam energy, irradiation time and target design. Accurate actinium assays, in turn, require efficient separation of actinium isotopes from both the Th matrix and highly radioactive activation by-products, especially radiolanthanides formed from proton-induced fission. In this study, we introduce a novel, selective chromatographic technique for the recovery and purification of actinium isotopes from irradiated Th matrices. A two-step sequence of cation exchange and extraction chromatography was implemented. Radiolanthanides were quantitatively removed from Ac, and no non-Ac radionuclidic impurities were detected in the final Ac fraction. An (225)Ac spike added prior to separation was recovered at ≥ 98%, and Ac decontamination from Th was found to be ≥ 10(6). The purified actinium fraction allowed for highly accurate (227)Ac determination at analytical scales, i.e., at (227)Ac activities of 1-100 kBq (27 nCi to 2.7 μCi). Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Dicty_cDB: SSI217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSI217 (Link to dictyBase) - - - Contig-U15348-1 SSI217Z (Link... to Original site) - - SSI217Z 662 - - - - Show SSI217 Library SS (Link to library) Clone ID SSI217 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSI2-A/SSI217Q.Seq.d/ Representative seq. ID SSI21...7Z (Link to Original site) Representative DNA sequence >SSI217 (SSI217Q) /CSM/SS/SSI2-A/SSI217Q.Seq.d/ XXXXX...Frames) Frame A: ---itlepilwplssivililqrn*lisygimgfqnknfscqlmvgi*lprspttillts ivisln*pfqqlkilqeyqcnl**pmmvii

  2. 25 CFR 217.5 - Management decisions.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Management decisions. 217.5 Section 217.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS MANAGEMENT OF TRIBAL ASSETS OF UTE... Management decisions. In arriving at management decisions concerning the assets, the business committee shall...

  3. 36 CFR 21.7 - Health examinations.

    Science.gov (United States)

    2010-07-01

    ... Section 21.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR HOT SPRINGS NATIONAL PARK; BATHHOUSE REGULATIONS § 21.7 Health examinations. No employee who comes in direct... Reference: For a list of communicable diseases included in the regulations of the United States...

  4. 22 CFR 217.11 - Discrimination prohibited.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discrimination prohibited. 217.11 Section 217... Discrimination prohibited. (a) General. (1) No qualified handicapped person shall, on the basis of handicap, be subjected to discrimination in employment under any program or activity to which this part applies. (2) A...

  5. 22 CFR 217.21 - Discrimination prohibited.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discrimination prohibited. 217.21 Section 217... Discrimination prohibited. No qualified handicapped person shall, because a recipient's facilities within the... excluded from participation in, or otherwise be subjected to discrimination under any program or activity...

  6. 14 CFR 145.217 - Contract maintenance.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Contract maintenance. 145.217 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.217 Contract maintenance. (a) A certificated repair station may contract a maintenance function pertaining to an article to...

  7. 40 CFR 86.217-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false 86.217-94 Section 86.217-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty...

  8. 43 CFR 17.217 - Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Existing facilities. 17.217 Section 17.217... facilities. (a) Accessibility. A recipient shall operate each program or activity so that when each part is... not require a recipient to make each of its existing facilities or every part of a facility...

  9. 27 CFR 24.217 - Vinegar stock.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Vinegar stock. 24.217... OF THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.217 Vinegar stock. Vinegar... commercial standards for the production of vinegar. Vinegar stock may be made only by the addition of...

  10. 48 CFR 1252.217-72 - Performance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance. 1252.217-72... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-72 Performance. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Performance (OCT 1994) (a)...

  11. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  12. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Energy Technology Data Exchange (ETDEWEB)

    Raeder, S., E-mail: s.raeder@gsi.de [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Bastin, B. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Block, M. [Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Institut für Kernchemie, Johannes Gutenberg Universität, 55128 Mainz (Germany); Creemers, P. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Ferrer, R. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fléchard, X. [LPC Caen, ENSICAEN, Université de Caen, CNRS/IN2P3, Caen (France); Franchoo, S. [Institute de Physique Nucléaire (IPN) d’Orsay, 91406 Orsay, Cedex (France); Ghys, L. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); SCK-CEN, Belgian Nuclear Research Center, Boeretang 200, 2400 Mol (Belgium); Gaffney, L.P.; Granados, C. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Heinke, R. [Institut für Physik, Johannes Gutenberg Universität, 55128 Mainz (Germany); Hijazi, L. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); and others

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  13. 48 CFR 252.217-7004 - Job orders and compensation.

    Science.gov (United States)

    2010-10-01

    ... compensation. 252.217-7004 Section 252.217-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.217-7004 Job orders and compensation. As prescribed in 217.7104(a), use the following clause: JOB ORDERS AND COMPENSATION (MAY 2006) (a) The Contracting Officer shall...

  14. Analysis list: Zfp217 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Zfp217 Pluripotent stem cell + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Zfp...217.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Zfp217.5.tsv http://dbarchive.biosc...iencedbc.jp/kyushu-u/mm9/target/Zfp217.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Zfp217.Plu

  15. 12 CFR 741.217 - Truth in savings.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Truth in savings. 741.217 Section 741.217 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS REQUIREMENTS FOR... Also Apply to Federally Insured State-Chartered Credit Unions § 741.217 Truth in savings. Any credit...

  16. 48 CFR 252.217-7015 - Safety and health.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Safety and health. 252.217... Clauses 252.217-7015 Safety and health. As prescribed in 217.7104(a), use the following clause: Safety and Health (DEC 1991) Nothing contained in the Master Agreement or any job order shall relieve the...

  17. 48 CFR 217.173 - Multiyear contracts for weapon systems.

    Science.gov (United States)

    2010-10-01

    ... weapon systems. 217.173 Section 217.173 Federal Acquisition Regulations System DEFENSE ACQUISITION... Mulityear Contracting 217.173 Multiyear contracts for weapon systems. As authorized by 10 U.S.C. 2306b(h... contract for— (a) A weapon system and associated items, services, and logistics support for a weapon system...

  18. 37 CFR 2.17 - Recognition for representation.

    Science.gov (United States)

    2010-07-01

    ... representation. 2.17 Section 2.17 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Representation by Attorneys Or Other Authorized Persons § 2.17 Recognition for representation. (a) Authority to practice in trademark cases. Only an...

  19. 25 CFR 217.6 - Method of casting votes.

    Science.gov (United States)

    2010-04-01

    ... the status quo. At the time they notify the superintendent of the votes cast on an issue, each joint... 25 Indians 1 2010-04-01 2010-04-01 false Method of casting votes. 217.6 Section 217.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS MANAGEMENT OF TRIBAL ASSETS...

  20. 22 CFR 217.42 - Admissions and recruitment.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Admissions and recruitment. 217.42 Section 217... Admissions and recruitment. (a) General. Qualified handicapped persons may not, on the basis of handicap, be denied admission or be subjected to discrimination in admission or recruitment by a recipient to which...

  1. 14 CFR 217.4 - Data collected (service classes).

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Data collected (service classes). 217.4 Section 217.4 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS REPORTING TRAFFIC STATISTICS BY FOREIGN AIR CARRIERS IN CIVILIAN SCHEDULED, CHARTER, AND NONSCHEDULED SERVICES §...

  2. 30 CFR 217.51 - Lease account reconciliation.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease account reconciliation. 217.51 Section... MANAGEMENT AUDITS AND INSPECTIONS Oil and Gas, General § 217.51 Lease account reconciliation. Specific lease account reconciliations shall be performed with priority being given to reconciling those lease...

  3. 30 CFR 217.301 - Lease account reconciliations.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease account reconciliations. 217.301 Section... MANAGEMENT AUDITS AND INSPECTIONS Geothermal Resources § 217.301 Lease account reconciliations. Specific lease account reconciliations will be performed with priority being given to reconciling those...

  4. 20 CFR 217.10 - Application filed after death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Application filed after death. 217.10 Section... APPLICATION FOR ANNUITY OR LUMP SUM Applications § 217.10 Application filed after death. (a) A survivor... expenses dies before applying for the lump-sum death payment under part 234 of this chapter....

  5. 34 CFR 668.217 - Default prevention plans.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Default prevention plans. 668.217 Section 668.217... Default prevention plans. (a) First year. (1) If your cohort default rate is equal to or greater than 30 percent you must establish a default prevention task force that prepares a plan to— (i) Identify...

  6. 49 CFR 173.217 - Carbon dioxide, solid (dry ice).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Carbon dioxide, solid (dry ice). 173.217 Section... Class 7 § 173.217 Carbon dioxide, solid (dry ice). (a) Carbon dioxide, solid (dry ice), when offered for... permit the release of carbon dioxide gas to prevent a buildup of pressure that could rupture...

  7. 28 CFR 2.17 - Original jurisdiction cases.

    Science.gov (United States)

    2010-07-01

    ... 2.17 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.17..., arrest, trial, or prisoner status, or because of the community status of the offender or his victim. (4...

  8. 48 CFR 217.171 - Multiyear contracts for services.

    Science.gov (United States)

    2010-10-01

    ... instructor skills (e.g., training for pilots and aircrew members or foreign language training). (iv) Base... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Multiyear contracts for services. 217.171 Section 217.171 Federal Acquisition Regulations System DEFENSE ACQUISITION...

  9. 49 CFR 1544.217 - Law enforcement personnel.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Law enforcement personnel. 1544.217 Section 1544... AND COMMERCIAL OPERATORS Operations § 1544.217 Law enforcement personnel. (a) The following applies to... for law enforcement personnel meeting the qualifications and standards specified in §§ 1542.215 and...

  10. A haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G.

    Science.gov (United States)

    Jain, Sudhir; Vinukonda, Govindaiah; Fiering, Steven N; Kumar, Ashok

    2008-12-01

    The human angiotensinogen (hAGT) gene contains an A/G polymorphism at -217, and frequency of -217A allele is increased in African-American hypertensive patients. The hAGT gene has seven polymorphic sites in the 1.2-kb region of its promoter, and variant -217A almost always occurs with -532T, -793A, and -1074T, whereas variant -217G almost always occurs with -532C, -793G, and -1074G. Since allele -6A is the predominant allele in African-Americans, the AGT gene can be subdivided into two main haplotypes, -6A:-217A (AA) and -6A:-217G (AG). To understand the role of these haplotypes on hAGT gene expression and on blood pressure regulation in an in vivo situation, we have generated double transgenic mice containing human renin gene and either AA or AG haplotype of the hAGT gene using knock-in strategy at the hypoxanthine phosphoribosyltransferase locus. We show here that 1) hAGT mRNA level is increased in the liver by 60% and in the kidney by 40%; and 2) plasma AGT level is increased by approximately 40%, and plasma angiotensin II level is increased by approximately 50% in male double transgenic mice containing AA haplotype of the hAGT gene compared with the AG haplotype. In addition, systolic blood pressure is increased by 8 mmHg in transgenic mice containing the AA haplotype compared with the AG haplotype. This is the first report to show the effect of polymorphisms in the promoter of a human gene on its transcription in an in vivo situation that ultimately leads to an increase in blood pressure.

  11. 12 CFR 217.1 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ...(t) of the Board's Regulation D—Reserve Requirements of Depository Institutions (12 CFR 20.4). ... 217.1 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... Reserve Act (12 U.S.C. 371a, 461, 505), section 7 of the International Banking Act of 1978 (12 U.S.C. 3105...

  12. 14 CFR 217.5 - Data collected (data elements).

    Science.gov (United States)

    2010-01-01

    .... This code represents the industry designator as described in the appendix to § 217.10 of this part. A common private industry source of these industry designator codes is the Official Airline Guides (OAG... this part. (4) Destination airport code. This represents the industry designator, from the source...

  13. 31 CFR 31.217 - Confidentiality of information.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Confidentiality of information. 31... RELIEF PROGRAM Conflicts of Interest § 31.217 Confidentiality of information. (a) Nonpublic information... shall take appropriate measures to ensure the confidentiality of nonpublic information and to prevent...

  14. 20 CFR 702.217 - Penalty for false statement, misrepresentation.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Penalty for false statement... PROCEDURE Claims Procedures Notice § 702.217 Penalty for false statement, misrepresentation. (a) Any..., or his dependents pursuant to section 9, 33 U.S.C. 909, if the injury results in death, shall...

  15. 49 CFR 1542.217 - Law enforcement personnel.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Law enforcement personnel. 1542.217 Section 1542... Law enforcement personnel. (a) Each airport operator must ensure that law enforcement personnel used... section must— (1) Meet the training standard for law enforcement officers prescribed by either the State...

  16. 78 FR 51809 - Seventeenth Meeting: RTCA Special Committee 217-Aeronautical Databases Joint With EUROCAE WG-44...

    Science.gov (United States)

    2013-08-21

    ... Federal Aviation Administration Seventeenth Meeting: RTCA Special Committee 217--Aeronautical Databases Joint With EUROCAE WG-44--Aeronautical Databases AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 217--Aeronautical Databases...

  17. 78 FR 66418 - Eighteenth Meeting: RTCA Special Committee 217-Aeronautical Databases Joint With EUROCAE WG-44...

    Science.gov (United States)

    2013-11-05

    ... Federal Aviation Administration Eighteenth Meeting: RTCA Special Committee 217--Aeronautical Databases Joint With EUROCAE WG-44--Aeronautical Databases AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 217--Aeronautical Databases...

  18. 78 FR 25134 - Sixteenth Meeting: RTCA Special Committee 217-Aeronautical Databases Joint With EUROCAE WG-44...

    Science.gov (United States)

    2013-04-29

    ... Federal Aviation Administration Sixteenth Meeting: RTCA Special Committee 217--Aeronautical Databases Joint With EUROCAE WG-44--Aeronautical Databases AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 217--Aeronautical Databases...

  19. 78 FR 8684 - Fifteenth Meeting: RTCA Special Committee 217-Aeronautical Databases Joint with EUROCAE WG-44...

    Science.gov (United States)

    2013-02-06

    ... Federal Aviation Administration Fifteenth Meeting: RTCA Special Committee 217--Aeronautical Databases Joint with EUROCAE WG-44--Aeronautical Databases AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 217--Aeronautical Databases...

  20. 48 CFR 1552.217-74 - Option for increased quantity-cost-plus-award-fee contract.

    Science.gov (United States)

    2010-10-01

    ... quantity-cost-plus-award-fee contract. 1552.217-74 Section 1552.217-74 Federal Acquisition Regulations... Texts of Provisions and Clauses 1552.217-74 Option for increased quantity—cost-plus-award-fee contract. As prescribed in 1517.208(e), insert this contract clause in cost-plus-award-fee term contracts when...

  1. 40 CFR 80.217 - How does a refiner or importer apply for the GPA standards?

    Science.gov (United States)

    2010-07-01

    ... for the GPA standards? 80.217 Section 80.217 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...-in Program § 80.217 How does a refiner or importer apply for the GPA standards? (a) To apply for the GPA standards under § 80.216, a refiner or importer must submit an application in accordance with the...

  2. 7 CFR 58.217 - Evaporators and/or vacuum pans.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Evaporators and/or vacuum pans. 58.217 Section 58.217....217 Evaporators and/or vacuum pans. Evaporators or vacuum pans or both, with open type condensers... Sanitary Standards for Milk and Milk Products Evaporators and Vacuum Pans. When enclosed type condensers...

  3. A haplotype of human angiotensinogen gene containing −217A increases blood pressure in transgenic mice compared with −217G

    OpenAIRE

    Jain, Sudhir; Vinukonda, Govindaiah; Fiering, Steven N; Kumar, Ashok

    2008-01-01

    The human angiotensinogen (hAGT) gene contains an A/G polymorphism at −217, and frequency of −217A allele is increased in African-American hypertensive patients. The hAGT gene has seven polymorphic sites in the 1.2-kb region of its promoter, and variant −217A almost always occurs with −532T, −793A, and −1074T, whereas variant −217G almost always occurs with −532C, −793G, and −1074G. Since allele −6A is the predominant allele in African-Americans, the AGT gene can be subdivided into two main h...

  4. The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression

    Science.gov (United States)

    Littlepage, Laurie E.; Adler, Adam S.; Kouros-Mehr, Hosein; Huang, Guiqing; Chou, Jonathan; Krig, Sheryl R.; Griffith, Obi L.; Korkola, James E.; Qu, Kun; Lawson, Devon A.; Xue, Qing; Sternlicht, Mark D.; Dijkgraaf, Gerrit J. P.; Yaswen, Paul; Rugo, Hope S.; Sweeney, Colleen A.; Collins, Colin C.; Gray, Joe W.; Chang, Howard Y.; Werb, Zena

    2013-01-01

    The transcription factor ZNF217 is a candidate oncogene in the amplicon on chromosome 20q13 that occurs in 20% to 30% of primary human breast cancers and that correlates with poor prognosis. We show that Znf217 overexpression drives aberrant differentiation and signaling events, promotes increased self-renewal capacity, mesenchymal marker expression, motility, and metastasis, and represses an adult tissue stem cell gene signature downregulated in cancers. By in silico screening, we identified candidate therapeutics that at low concentrations inhibit growth of cancer cells expressing high ZNF217. We show that the nucleoside analogue triciribine inhibits ZNF217-induced tumor growth and chemotherapy resistance and inhibits signaling events [e.g., phospho-AKT, phospho-mitogen-activated protein kinase (MAPK)] in vivo. Our data suggest that ZNF217 is a biomarker of poor prognosis and a therapeutic target in patients with breast cancer and that triciribine may be part of a personalized treatment strategy in patients overexpressing ZNF217. Because ZNF217 is amplified in numerous cancers, these results have implications for other cancers. SIGNIFICANCE This study finds that ZNF217 is a poor prognostic indicator and therapeutic target in patients with breast cancer and may be a strong biomarker of triciribine treatment efficacy in patients. Because previous clinical trials for triciribine did not include biomarkers of treatment efficacy, this study provides a rationale for revisiting triciribine in the clinical setting as a therapy for patients with breast cancer who overexpress ZNF217. PMID:22728437

  5. Proton Polarimeter Calibration between 82 and 217 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Glister, J; Lee, B; Beck, A; Brash, E; Camsonne, A; Choi, S; Dumas, J; Feuerbach, R; Gilman, R; Higinbotham, D W; Jiang, X; Jones, M K; May-Tal Beck, S; McCullough, E; Paolone, M; Piasetzky, E; Roche, J; Rousseau, Y; Sarty, A J; Sawatzky, B; Strauch, S

    2009-07-01

    The proton analyzing power in carbon has been measured for energies of 82 to 217 MeV and proton scattering angles of 5 to 41 degrees. The measurements were carried out using polarized protons from the elastic scattering H(pol. e, pol. p) reaction and the Focal Plane Polarimeter (FPP) in Hall A of Jefferson Lab. A new parameterization of the FPP p-C analyzing power was fit to the data, which is in good agreement with previous parameterizations and provides an extension to lower energies and larger angles. The main conclusions are that all polarimeters to date give consistent measurements of the carbon analyzing power, independently of the details of their construction and that measuring on a larger angular range significantly improves the polarimeter figure of merit at low energies.

  6. 9 CFR 93.217 - Import permit and declaration for poultry.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Import permit and declaration for poultry. 93.217 Section 93.217 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH,...

  7. 36 CFR 223.217 - Authority to dispose of special forest products.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Authority to dispose of special forest products. 223.217 Section 223.217 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Special Forest Products §...

  8. 42 CFR 93.217 - Office of Research Integrity or ORI.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Office of Research Integrity or ORI. 93.217 Section 93.217 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH...

  9. 20 CFR 217.7 - Claim filed with the Social Security Administration.

    Science.gov (United States)

    2010-04-01

    ... Administration. (a) Claim is for life benefits. An application for life benefits under title II of the Social... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Claim filed with the Social Security Administration. 217.7 Section 217.7 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE...

  10. 48 CFR 217.175 - Multiyear contracts for electricity from renewable energy sources.

    Science.gov (United States)

    2010-10-01

    ... electricity from renewable energy sources. 217.175 Section 217.175 Federal Acquisition Regulations System... renewable energy sources. (a) The head of the contracting activity may enter into a contract for a period not to exceed 10 years for the purchase of electricity from sources of renewable energy, as that...

  11. 48 CFR 1552.217-72 - Option to extend the term of the contract-cost-plus-award-fee contract.

    Science.gov (United States)

    2010-10-01

    ... of the contract-cost-plus-award-fee contract. 1552.217-72 Section 1552.217-72 Federal Acquisition... CLAUSES Texts of Provisions and Clauses 1552.217-72 Option to extend the term of the contract—cost-plus-award-fee contract. As prescribed in 1517.208(c), insert this contract clause in cost-plus-award-fee...

  12. MiR-217 is down-regulated in psoriasis and promotes keratinocyte differentiation via targeting GRHL2

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Haigang; Hou, Liyue; Liu, Jingjing; Li, Zhiming, E-mail: lizm_1001@sina.com

    2016-02-26

    MiR-217 is a well-known tumor suppressor, and its down-regulation has been shown in a wide range of solid and leukaemic cancers. However, the biological role of miR-217 in psoriasis pathogenesis, especially in keratinocyte hyperproliferation and differentiation, is not clearly understood. In this study, we found the expression of miR-217 was markedly down-regulated in psoriasis keratinocytes of psoriatic patients. In addition, overexpression of miR-217 inhibited the proliferation and promoted the differentiation of primary human keratinocytes. On the contrary, inhibition of endogenous miR-217 increased cell proliferation and delayed differentiation. Furthermore, Grainyhead-like 2 (GRHL2) was identified as a direct target of miR-217 by luciferase reporter assay. The expression of miR-217 and GRHL2 was inversely correlated in both transfected keratinocytes and in psoriasis lesional skin. Moreover, knocking down GRHL2 expression by siRNA enhanced keratinocyte differentiation. Taken together, our results demonstrate a role for miR-217 in the regulation of keratinocyte differentiation, partially through the regulation of GRHL2. - Highlights: • miR-217 is down-regulated in psoriasis skin lesions. • miR-217 inhibits the proliferation and promotes differentiation of keratinocytes. • GRHL2 is a novel target of miR-217 in keratinocytes. • GRHL2 is up-regulated and inversely correlated with miR-217 in psoriasis skin lesions.

  13. 49 CFR 40.217 - Where is other information on the role of STTs and BATs found in this regulation?

    Science.gov (United States)

    2010-10-01

    ... BATs found in this regulation? 40.217 Section 40.217 Transportation Office of the Secretary of... Personnel § 40.217 Where is other information on the role of STTs and BATs found in this regulation? You can find other information on the role and functions of STTs and BATs in the following sections of...

  14. Mir-217/Sirt1 pathway and diabetic nephropathy%Mir-217/Sirt1通路与糖尿病肾病

    Institute of Scientific and Technical Information of China (English)

    邵滢; 王秋月

    2015-01-01

    Mir-217 is an important member of the miRNAs family overexpressed in high glucose cultured glomerular mesangial cells.Sirt1 is an NAD (+)-dependent deacetylase,which has obtained great focus on the research of aging.Recent researches reported that Sirt1 has protective functions in diabetic nephropathy such as anti-inflammation,anti-oxidance and anti-fibrosis.In a variety of pathological conditions,mir-217 directly acts on the 3 ' translation section of Sirt1 mRNA,and inhibits expression of Sirt1 protein.Thus,mir-217/Sirt1 pathway may play a key role in the occurrence and development of diabetic nephropathy.%Mir-217是miRNAs家族的重要成员,在高糖培养的肾小球系膜细胞中表达量升高.Sirt1是一个NAD+调节的脱乙酰酶,既往在衰老性疾病中研究较多,近期发现其在糖尿病肾病中起到抗炎、抗氧化、抗纤维化等保护作用.研究指出,在多种病理条件下mir-217通过直接作用于Sirt1mRNA的3'非翻译区,显著抑制Sirt1蛋白表达,因此mir-217/Sirt1通路可能在糖尿病肾病的发生、发展中起关键作用.

  15. A haplotype of human angiotensinogen gene containing −217A increases blood pressure in transgenic mice compared with −217G

    Science.gov (United States)

    Jain, Sudhir; Vinukonda, Govindaiah; Fiering, Steven N.; Kumar, Ashok

    2008-01-01

    The human angiotensinogen (hAGT) gene contains an A/G polymorphism at −217, and frequency of −217A allele is increased in African-American hypertensive patients. The hAGT gene has seven polymorphic sites in the 1.2-kb region of its promoter, and variant −217A almost always occurs with −532T, −793A, and −1074T, whereas variant −217G almost always occurs with −532C, −793G, and −1074G. Since allele −6A is the predominant allele in African-Americans, the AGT gene can be subdivided into two main haplotypes, −6A:−217A (AA) and −6A:−217G (AG). To understand the role of these haplotypes on hAGT gene expression and on blood pressure regulation in an in vivo situation, we have generated double transgenic mice containing human renin gene and either AA or AG haplotype of the hAGT gene using knock-in strategy at the hypoxanthine phosphoribosyltransferase locus. We show here that 1) hAGT mRNA level is increased in the liver by 60% and in the kidney by 40%; and 2) plasma AGT level is increased by ∼40%, and plasma angiotensin II level is increased by ∼50% in male double transgenic mice containing AA haplotype of the hAGT gene compared with the AG haplotype. In addition, systolic blood pressure is increased by 8 mmHg in transgenic mice containing the AA haplotype compared with the AG haplotype. This is the first report to show the effect of polymorphisms in the promoter of a human gene on its transcription in an in vivo situation that ultimately leads to an increase in blood pressure. PMID:18945948

  16. Time-differential observation of alpha -particle perturbed angular distribution; g-factor measurements for /sup 217/Ac/sup gs/ and /sup 217/Ac/sup m/

    CERN Document Server

    Maier, K H; Grawe, H; Kluge, H

    1981-01-01

    The g-factor measurements of the ground state and an isomeric level in /sup 217/Ac using the DPAD method with alpha -decay are described. The results of gamma -ray g-factor measurements for the isomer and a tentative decay scheme produced by alpha - gamma and gamma - gamma coincidence experiments are also presented. An analysis of the alpha - particle angular distributions suggests that nuclear deformation affects the observed anisotropy. (13 refs).

  17. CULTIVAR RELEASE-BRS 217 Flora: Early-maturing soybean cultivar

    Directory of Open Access Journals (Sweden)

    Plínio Itamar de Mello de Souza

    2008-01-01

    Full Text Available The soybean (Glycine max L. Merr. cultivar BRS 217 Flora was developed by Embrapa and released forproduction in the states of Goiás, Minas Gerais, Bahia, Mato Grosso and the Distrito Federal, Brazil. It is resistant to stemcanker, frog-eye leaf spot, bacterial pustule, and partially resistant to powdery mildew.

  18. 5 CFR 531.217 - Special conversion rules for certain non-GS employees.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Special conversion rules for certain non... SERVICE REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay Setting Pay When Appointment Or Position Changes § 531.217 Special conversion rules for certain non-GS employees. When...

  19. 49 CFR 375.217 - How must I collect charges upon delivery?

    Science.gov (United States)

    2010-10-01

    ... charge or credit card, you must arrange with the individual shipper for the delivery only at a time when... must relinquish possession of the shipment at the time of delivery. [68 FR 35091, June 11, 2003, as... 49 Transportation 5 2010-10-01 2010-10-01 false How must I collect charges upon delivery? 375.217...

  20. 20 CFR 217.11 - “Good cause” for delay in filing application.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT ACT APPLICATION FOR ANNUITY OR LUMP SUM Applications § 217.11 “Good cause” for delay in filing application. (a) An applicant has “good cause” for a delay in the filing of an application for a lump-sum... time limit. (b) An applicant does not have good cause for a delay in filing if he or she was...

  1. Yeast Interacting Proteins Database: YHR114W, YDL217C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available y (0) YDL217C TIM22 Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopi...rey gene name TIM22 Prey description Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic

  2. Yeast Interacting Proteins Database: YBR217W, YMR159C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YBR217W ATG12 Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated...ption Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to fo

  3. Yeast Interacting Proteins Database: YBR217W, YLR423C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YBR217W ATG12 Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated...scription Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p t

  4. 20 CFR 725.217 - Determination of dependency; surviving divorced spouse.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; surviving... Benefits) § 725.217 Determination of dependency; surviving divorced spouse. An individual who is the miner's surviving divorced spouse (see § 725.216) shall be determined to have been dependent on the...

  5. 77 FR 47492 - Thirteenth Meeting: RTCA Special Committee 217, Terrain and Airport Mapping Databases, Joint With...

    Science.gov (United States)

    2012-08-08

    ... Mapping Databases, Joint With EUROCAE WG-44 AGENCY: Federal Aviation Administration (FAA), U.S. Department... Mapping Databases, Joint with EUROCAE WG-44. SUMMARY: The FAA is issuing this notice to advise the public of the thirteenth meeting of RTCA Special Committee 217, Terrain and Airport Mapping Databases, Joint...

  6. 19 CFR 10.217 - Verification and justification of claim for preferential treatment.

    Science.gov (United States)

    2010-04-01

    .... Textile and Apparel Articles Under the African Growth and Opportunity Act § 10.217 Verification and... of the article in question, such as purchase orders, invoices, bills of lading and other shipping... importer came to the conclusion that the textile or apparel article qualifies for preferential...

  7. Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery.

    Science.gov (United States)

    Carter, Wendy J; Myles, Timothy; Gibbs, Craig S; Leung, Lawrence L; Huntington, James A

    2004-06-18

    Thrombin is the ultimate protease of the blood clotting cascade and plays a major role in its own regulation. The ability of thrombin to exhibit both pro- and anti-coagulant properties has spawned efforts to turn thrombin into an anticoagulant for therapeutic purposes. This quest culminated in the identification of the E217K variant through scanning and saturation mutagenesis. The antithrombotic properties of E217K thrombin are derived from its inability to convert fibrinogen to a fibrin clot while maintaining its thrombomodulin-dependent ability to activate the anticoagulant protein C pathway. Here we describe the 2.5-A crystal structure of human E217K thrombin, which displays a dramatic restructuring of the geometry of the active site. Of particular interest is the repositioning of Glu-192, which hydrogen bonds to the catalytic Ser-195 and which results in the complete occlusion of the active site and the destruction of the oxyanion hole. Substrate binding pockets are further blocked by residues previously implicated in thrombin allostery. We have concluded that the E217K mutation causes the allosteric inactivation of thrombin by destabilizing the Na(+) binding site and that the structure thus may represent the Na(+)-free, catalytically inert "slow" form.

  8. 76 FR 70531 - Tenth Meeting: RTCA Special Committee 217/EUROCAE WG-44: Terrain and Airport Mapping Databases

    Science.gov (United States)

    2011-11-14

    ... Airport Mapping Databases AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation... RTCA Special Committee 217/EUROCAE WG-44: Terrain and Airport Mapping Databases: For the tenth meeting... meeting of RTCA Special Committee 217/EUROCAE WG-44: Terrain and Airport Mapping Databases. The agenda...

  9. 30 CFR 250.217 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What solid and liquid wastes and discharges information and cooling water intake information must accompany the EP? 250.217 Section 250.217 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF...

  10. Adverse Drug Reactions in 2013:Analysis of 217 Cases%2013年217例药品不良反应报告分析

    Institute of Scientific and Technical Information of China (English)

    宋锦飞; 徐琳; 孙光春

    2014-01-01

    目的:了解复旦大学附属上海市第五人民医院(以下简称“我院”)药品不良反应( ADR)的发生情况,以促进临床合理用药。方法:回顾性调查2013年我院收集的217例ADR报告,从患者的年龄、性别、药品种类、给药途径等方面进行统计、分析。结果:217例ADR中,男女患者比例为0�7∶1�0;≥60岁患者78例(占35�94%);静脉给药147例(占67�74%),口服给药59例(占27�19%);抗感染药致ADR 119例,居首位;ADR临床表现主要为皮肤及其附件损害(80例,占36�87%)。结论:应加强医院ADR监测工作,合理、规范使用抗感染药,避免或减少严重的ADR发生。%OBJECTIVE:To investigate the characteristics of adverse drug reaction ( ADR ) in Shanghai Fifth People�s Hospital Affiliated to Fudan University ( hereinafter referred to as “our hospital“) so as to promote clinical rational use of drug. METHODS:217 ADR cases collected in our hospital during 2013 were analyzed statistically in terms of patients�age and gender, drug types and route of administration etc. RESULTS:The 217 ADR cases occurred in male/female ratio of 0�7∶ 1; 78 cases ( 35�94%) aged ≥60 years; 147 cases ( 67�74%) were induced via intravenous injection;59 cases(27�19%) were induced by oral drugs;the anti⁃infective drugs ranked the first in terms of ADR incidence; 80 cases ( 36�87%) manifested as lesions of skin and its appendants. CONCLUSIONS: It is important to strengthen ADR monitoring in hospital and achieve rational and standard use of anti⁃infective drugs so as to avoid or reduce the occurrence of severe ADR.

  11. Cytogenetic analysis of 217 couples with adverse pregnancy history%217对不良孕产史夫妇细胞遗传学分析

    Institute of Scientific and Technical Information of China (English)

    何淑贞; 蒲育栋; 曹金如; 陈美玲; 苏焕厚; 邓汉钊; 莫丽芳

    2016-01-01

    目的:探讨不良孕产史与外周血染色体核型之间的关系,为遗传咨询提供依据。方法采集2013年1月至2015年11月来我院就诊的217对不良孕产史患者的外周血,分别进行外周血淋巴细胞培养、制做玻片和G显带后核型分析。结果217对不良孕产史夫妇中共发现染色体异常的核型9例,异常染色体核型检出率为2.07%,多态性核型55例,检出率为12.67%。结论染色体异常是造成患者发生不良孕产史的主要原因之一,因此应对存在不良孕产史的夫妇常规开展细胞遗传学检查及适时的遗传咨询。%Objective To investigate the relationship between abnormal pregnancy and peripheral blood karyo-type, and provide the basis for genetic counseling. Methods The peripheral blood of 217 couples with adverse pregnan-cy history were collected in our hospital from January 2013 to November 2015. Then the peripheral blood lymphocytes were cultured, and karyotype analysis of G banding was carried out. Results Among 217 couples, 9 cases were found with abnormal karyotype (with the detection rate of 2.07%), and 55 cases were found with polymorphic karyotype (with the detection rate of 12.67%). Conclusion Chromosomal abnormality is an important reason that leads to adverse preg-nancy history. Therefore, the couples with adverse pregnancy history should receive routine prenatal cytogenetic exami-nation and consultation to prevent birth defects, and improve the quality of the birth service.

  12. The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5.

    Directory of Open Access Journals (Sweden)

    Hui Wang

    Full Text Available Gastric cancer (GC is one of the most common malignancies worldwide. Emerging evidence has shown that aberrant expression of microRNAs (miRNAs plays important roles in cancer progression. However, little is known about the potential role of miR-217 in GC. In this study, we investigated the role of miR-217 on GC cell proliferation and invasion. The expression of miR-217 was down-regulated in GC cells and human GC tissues. Enforced expression of miR-217 inhibited GC cells proliferation and invasion. Moreover, Glypican-5 (GPC5, a new ocncogene, was identified as the potential target of miR-217. In addition, overexpression of miR-217 impaired GPC5-induced promotion of proliferation and invasion in GC cells. In conclusion, these findings revealed that miR-217 functioned as a tumor suppressor and inhibited the proliferation and invasion of GC cells by targeting GPC5, which might consequently serve as a therapeutic target for GC patients.

  13. Clinical Analysis of 217 Children with Hearing Loss%217例听力损失儿童临床特点分析

    Institute of Scientific and Technical Information of China (English)

    蔡娟; 邹凌; 陶宣华; 杨馨婷

    2015-01-01

    Objective To investigate the children with hearing loss which didn’t have newborn hearing screening,and dis-cuss their found age and audiological characteristics. Methods From Oct 2009 to Sep 2013,total of 217 children have diagnosed hearing loss. General information of found age were investigated,and then made statistical analysis. Results The average found age for 43 children with bilateral moderate hearing loss was(55. 3 ± 13. 8)months,and the average found age for 52 children with bilateral severe hearing loss was(32. 0 ± 11. 4) months,the average found age for 79 children with bilateral profound hearing loss was(20.2 ±9.8)months. The average found age for 9 children with unilateral severe hearing loss was(96.1 ±7.6)months,The average found age for 34 children with unilateral profound hearing loss was ( 94. 2 ± 8. 1 ) months. Conclusion The unilateral hearing loss and as the hearing loss degree of children went milder,The found age might be later. It is necessary to popularize new-born hearing screening ,while to enhance the parents’ consciousness,thus promoting the early detection, diagnosis and interven-tion for children with hearing impairment.%目的:探讨未经过新生儿听力筛查,由于听力、语言发育落后而就诊,并诊断为听力损失的217例儿童的听力损失程度、特点及首诊年龄。方法对2009年10月至2013年9月到我院就诊的217例儿童,进行听力学诊断评估。结果217例听力损失患儿中,双耳中度43例,平均首诊发现年龄(55.3±13.8)个月,双耳重度52例,平均发现年龄(32.0±11.4)个月,双耳极重度79例,平均发现年龄(20.2±9.8)个月,单耳重度9例,平均发现年龄(96.1±7.6)个月,单耳极重度34例,平均发现年龄(94.2±8.1)个月。结论单耳听力损失及听力损失程度越轻的患儿,其发现年龄越晚。进行新生儿听力筛查能在6个月龄内早期发现听力损失,并及时康复干预

  14. Triggered star formation at the borders of the H ii region Sh 2-217

    Science.gov (United States)

    Brand, J.; Massi, F.; Zavagno, A.; Deharveng, L.; Lefloch, B.

    2011-03-01

    Context. This paper is part of our ongoing study of star formation at the borders of Galactic H ii regions. In this paper, we report our observations and analysis of Sharpless 217 (Sh 2-217). Aims: We study the stars and gas in and around H ii regions to see if the various physical parameters derived from the data (such as column densities, masses, sizes, and timescales) are consistent with the predictions of a simple model of the collect-and-collapse mechanism. This should indicate whether stars forming in molecular gas at the borders of the H ii regions could have been triggered by the expansion of the ionized gas. Methods: We observed the emission of various molecules and transitions towards Sh 2-217, and obtained both near-infrared photometry in the H and K bands, and near-infrared images in [Fe ii] and H2 narrow-band filters of the stars in a molecular condensation at the edge of the H ii region, where an UC H ii region is also located. For the atomic and ionized hydrogen gas, we used literature data. Results: Several molecular condensations are found on the borders of Sh 2-217 and both behind and in front of the ionized emission. We find signs of star formation (an UC H ii region, outflows, and water masers). The masses of the larger molecular condensations, derived from 13CO-data, are ≳330-1100 M⊙, while smaller clumps or cores within them have up to several tens of solar masses. The morphology of the atomic and molecular gas associated with Sh 2-217, especially the condensations of molecular gas on its border, and the presence of star forming activity within them, is strongly indicative of it being the result of star formation triggered by the expansion of the ionized region, following the collect-and-collapse scenario. Application of a simple model illustrates that the present radii of both Sh 2-217 and the UC H ii region, the masses of the condensations, and the timescales needed to sweep up these amounts of gas and allow massive stars to form in them

  15. Radioisotope space power generator. Annual report, July 1, 1975--September 30, 1976. [TPM-217 P-type selenides

    Energy Technology Data Exchange (ETDEWEB)

    Elsner, N.B.; Chin, J.; Staley, H.G.; Steeger, E.J.; Gantzel, P.K.

    1977-09-01

    TPM-217 P-type selenide usefulness in thermoelectric converters depends on its dimensional, electrical and thermal stability at high temperature and its compatibility with other converter component materials in a low pressure environment. Experimental efforts have been directed at determining: the vaporization behavior at 900/sup 0/C, the partial pressures of vaporizing species versus temperature, vapor suppression coatings, thermal expansion, dimensional stability, and the high temperature compatibility of TPM-217 with proposed end cap materials.

  16. Accretion-ejection connection in the young brown dwarf candidate ISO-Cha1 217

    CERN Document Server

    Whelan, E T; Bacciotti, F; Nisini, B; Bonito, R; Antoniucci, S; Stelzer, B; Biazzo, K; D'Elia, V; Ray, T P

    2014-01-01

    As the number of observed brown dwarf outflows is growing it is important to investigate how these outflows compare to the well studied jets from young stellar objects. A key point of comparison is the relationship between outflow and accretion activity and in particular the ratio between the mass outflow and accretion rates ($\\dot{M}_{out}$/$\\dot{M}_{acc}$). The brown dwarf candidate ISO-ChaI 217 was discovered by our group, as part of a spectro-astrometric study of brown dwarfs, to be driving an asymmetric outflow with the blue-shifted lobe having a position angle of $\\sim$ 20$^{\\circ}$. The aim here is to further investigate the properties of ISO-ChaI 217, the morphology and kinematics of its outflow, and to better constrain ($\\dot{M}_{out}$/$\\dot{M}_{acc}$). The outflow is spatially resolved in the $[SII]\\lambda \\lambda 6716,6731$ lines and is detected out to $\\sim$ 1\\farcs6 in the blue-shifted lobe and ~ 1" in the red-shifted lobe. The asymmetry between the two lobes is confirmed although the velocity as...

  17. Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A

    Energy Technology Data Exchange (ETDEWEB)

    Gandhi, Prafull S.; Page, Michael J.; Chen, Zhiwei; Bush-Pelc, Leslie; Di Cera, Enrico; (WU-MED)

    2009-09-15

    The thrombin mutant W215A/E217A (WE) is a potent anticoagulant both in vitro and in vivo. Previous x-ray structural studies have shown that WE assumes a partially collapsed conformation that is similar to the inactive E* form, which explains its drastically reduced activity toward substrate. Whether this collapsed conformation is genuine, rather than the result of crystal packing or the mutation introduced in the critical 215-217 {beta}-strand, and whether binding of thrombomodulin to exosite I can allosterically shift the E* form to the active E form to restore activity toward protein C are issues of considerable mechanistic importance to improve the design of an anticoagulant thrombin mutant for therapeutic applications. Here we present four crystal structures of WE in the human and murine forms that confirm the collapsed conformation reported previously under different experimental conditions and crystal packing. We also present structures of human and murine WE bound to exosite I with a fragment of the platelet receptor PAR1, which is unable to shift WE to the E form. These structural findings, along with kinetic and calorimetry data, indicate that WE is strongly stabilized in the E* form and explain why binding of ligands to exosite I has only a modest effect on the E*-E equilibrium for this mutant. The E* {yields} E transition requires the combined binding of thrombomodulin and protein C and restores activity of the mutant WE in the anticoagulant pathway.

  18. Expressions and significance of ZNF217 in papillary thyroid carcinoma%锌指蛋白217在甲状腺乳头状癌组织中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    张丽婷; 吴文艺; 王朝阳; 黄种心; 朱世泽

    2013-01-01

    Objective To investigate the expression and clinical significance of zinc finger gene 217 (ZNF217) in human papillary thyroid carcinoma.Methods The expressions of ZNF217 mRNA and protein were detected by quantitative realtime PCR and Western blot in papillary thyroid carcinoma tissues (n =20) and adjacent normal tissues (n =20),and the data were analyzed.Results The expressions of ZNF217 mRNA and protein in papillary thyroid carcinoma were significantly higher than those in adjacent normal tissues (96.72 ± 44.19 vs 4.86 ±3.55,0.994 ± 0.172 vs 0.195 ± 0.061,both P<0.01),being higher in the papillary thyroid carcinoma with capsule invasion compared with that without capsule invasion (P<0.01).The expressions of ZNF217 mRNA and protein in papillary thyroid carcinoma were not related to gender,age,tumor size,TNM stage or lymph node metastasis (all P>0.05).Conclusions The overexpression of ZNF217 may be associated with the oncogenesis and progress of papillary thyroid carcinoma and capsule invasion,and thus is expected to become a new target for prevention and treatment of papillary thyroid carcinoma.%目的 探讨锌指蛋白217 (ZNF217)在人类甲状腺乳头状癌组织中的表达及其意义.方法 利用实时荧光定量PCR法和Western印迹法检测20例甲状腺乳头状癌组织及相应的20例癌旁正常组织中ZNF217的mRNA和蛋白表达水平,并进行统计学分析.结果 ZNF217 mRNA和蛋白在甲状腺乳头状癌组织中的表达显著高于癌旁正常甲状腺组织(96.72±44.19对4.86±3.55,0.994±0.172对0.195±0.061,均P<0.01),在甲状腺乳头状癌包膜侵犯组高于无包膜侵犯组(P<0.01).ZNF217 mRNA和蛋白的表达与患者的性别、年龄、肿瘤大小、TNM分期及有无淋巴结转移均无关(均P>0.05).结论 ZNF217的过表达可能与甲状腺乳头状癌的发生发展和包膜侵犯有关,有望成为甲状腺乳头状癌预防和治疗的一个新的靶点.

  19. ZNF217在宫颈上皮内瘤变及宫颈癌中的表达及意义%The expression and significance of ZNF217 in human cervical intraepithelial neoplasia and cervical carcinoma

    Institute of Scientific and Technical Information of China (English)

    郝汇平; 纪新强; 王晓红

    2014-01-01

    Objective To detect the expressions of zinc finger protein 217 ( ZNF217 ) in human normal cervical epithelium , cervical intraepithelial neoplasia ( CIN) and cervical carcinoma to investigate the roles of ZNF 217 in the carcinogenesis and development of cervical carcinoma, and to provide theoretical basis for clinical diagnosis and therapy .Methods The expressions of ZNF217 were detected by immunohistochemistry SP method in 60 patients with cervical carcinoma ( cervical carcinoma group ) , 18 cases with low grade of cervical intraepithelial neoplasia (CIN Ⅰgroup), 32 cases with high grade of cervical intraepithelial neoplasia (CIN Ⅱ-Ⅲ group) and 20 cases with normal cervical epithelium ( normal group ) .Results ZNF217 was mainly located in cervical cytoplasm .The positive-expression rate of ZNF217 was 25.0%, 33.3%, 50.0% and 81.5% in normal cervical epithelium tissues , CIN Ⅰ tissues, CIN Ⅱ-Ⅲtissues and the tissues of cervical carcinoma , respectively.There was significant difference in the positive-expression rate of ZNF217 between cervical carcinoma group and normal cervical epithelium group , between CINⅠgroup and cervical carcinoma group , between CINⅡ-Ⅲgroup and cervical carcinoma group (χ2 value was 18.755, 12.874 and 7.762, respectively, all P0.05 ).In the cervical carcinoma group , the expression of ZNF217 was correlated with histological grade and lymphatic metastasis (χ2 value was 12.851 and 6.222, respectively, both P0.05).Conclusion High expression of ZNF217 plays an important role in the carcinogenesis and development of cervical carcinoma .%目的:研究ZNF217在宫颈癌、宫颈上皮内瘤变及正常宫颈组织中的表达,探讨ZNF217在宫颈癌的发生、发展中的作用,为宫颈癌的临床诊断和治疗提供重要的理论依据。方法采用免疫组织化学SP法检测ZNF217在60例宫颈癌(宫颈癌组)、18例低度宫颈上皮内瘤变( CINⅠ组)、32例高度宫颈上皮内瘤变( CIN

  20. HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr{sup −/−} mice

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Junghyun; Kim, Chan-Sik; Jo, Kyuhyung [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Cho, Yun-Seok; Kim, Hyun-Gyu; Lee, Geun-Hyeog [Research and Development Center, Hanlim Pharm. Co. Ltd., 1656-10, Seocho-dong, Seocho-gu, Seoul (Korea, Republic of); Lee, Yun Mi; Sohn, Eunjin [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Kim, Jin Sook, E-mail: jskim@kiom.re.kr [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of)

    2015-01-02

    Highlights: • HL-217 is a new synthetic topical anti-angiogenic agent. • HL-217 attenuated subretinal neovascularization in Vldlr{sup −/−} mice. • HL-217 blocked the binding of PDGF-BB to PDGFRβ. - Abstract: HL-217 is a new synthetic angiogenesis inhibitor. Platelet derived growth factor (PDGF) is a vasoactive factor and has been implicated in proliferative retinopathies. In this study, we examined the mechanism of action and efficacy of topical application of HL-217 on subretinal neovascularization in very low-density lipoprotein receptor knockout (Vldlr{sup −/−}) mice. In three-week-old male Vldlr{sup −/−} mice, HL-217 (1.5 or 3 mg/ml) was administered twice per day for 4 weeks by topical eye drop instillation. Neovascular areas were then measured. We used a protein array to evaluate the expression levels of angiogenic factors. The inhibitory effect of HL-217 on the PDGF-BB/PDGFRβ interaction was evaluated in vitro. The neovascular area in the Vldlr{sup −/−} mice was significantly reduced by HL-217. Additionally, HL-217 decreased the expression levels of PDGF-BB protein and VEGF mRNA. Moreover, HL-217 dose-dependently inhibited the PDGF-BB/PDGFRβ interaction (IC{sub 50} = 38.9 ± 0.7 μM). These results suggest that HL-217 is a potent inhibitor of PDGF-BB. HL-217, when applied topically, is an effective inhibitor of subretinal neovascularization due to its ability to inhibit the pro-angiogenic effects of PDGF-BB.

  1. HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr⁻/⁻ mice.

    Science.gov (United States)

    Kim, Junghyun; Kim, Chan-Sik; Jo, Kyuhyung; Cho, Yun-Seok; Kim, Hyun-Gyu; Lee, Geun-Hyeog; Lee, Yun Mi; Sohn, Eunjin; Kim, Jin Sook

    2015-01-02

    HL-217 is a new synthetic angiogenesis inhibitor. Platelet derived growth factor (PDGF) is a vasoactive factor and has been implicated in proliferative retinopathies. In this study, we examined the mechanism of action and efficacy of topical application of HL-217 on subretinal neovascularization in very low-density lipoprotein receptor knockout (Vldlr(-/-)) mice. In three-week-old male Vldlr(-/-) mice, HL-217 (1.5 or 3mg/ml) was administered twice per day for 4 weeks by topical eye drop instillation. Neovascular areas were then measured. We used a protein array to evaluate the expression levels of angiogenic factors. The inhibitory effect of HL-217 on the PDGF-BB/PDGFRβ interaction was evaluated in vitro. The neovascular area in the Vldlr(-/-) mice was significantly reduced by HL-217. Additionally, HL-217 decreased the expression levels of PDGF-BB protein and VEGF mRNA. Moreover, HL-217 dose-dependently inhibited the PDGF-BB/PDGFRβ interaction (IC50=38.9 ± 0.7 μM). These results suggest that HL-217 is a potent inhibitor of PDGF-BB. HL-217, when applied topically, is an effective inhibitor of subretinal neovascularization due to its ability to inhibit the pro-angiogenic effects of PDGF-BB.

  2. The ZNF217 Breast Cancer Oncogene Amplified at 20q13: A Potential Marker for Invasiveness

    Science.gov (United States)

    2012-03-01

    samples  amplified  at  20q13. We  previously  optimized  the  nuclear specific  immunohistochemistry  (supervised by the  collaborating  pathologist Dr...correlative  significance  with  ZNF217  expression  in  collaboration   with  the  biostatistician  (see  letter  of  collaboration  with Dr. Beckett who will...procedures (buildings, clinics, etc.). Note: IRB approval applies only to UC Davis organizations. Unless a written interinstitutional agreement has

  3. MicroRNA-217 suppresses homocysteine-induced proliferation and migration of vascular smooth muscle cells via N-methyl-D-aspartic acid receptor inhibition.

    Science.gov (United States)

    Duan, Hongyan; Li, Yongqiang; Yan, Lijie; Yang, Haitao; Wu, Jintao; Qian, Peng; Li, Bing; Wang, Shanling

    2016-10-01

    Hyperhomocysteine has become a critical risk for atherosclerosis and can stimulate proliferation and migration of vascular smooth muscle cells (VSMCs). N-methyl-D-aspartic acid receptor (NMDAR) is a receptor of homocysteine and mediates the effects of homocysteine on VSMCs. Bioinformatics analysis has shown NMDAR is a potential target of microRNA-217 (miR-217), which exerts multiple functions in cancer tumorigenesis and carotid plaque progression. In this study, we sought to investigate the role of miR-217 in VSMCs phenotype transition under homocysteine exposure and elucidate its effect on atherosclerotic plaque formation. After treating with several doses of homocysteine (0-8 × 10(-4)  mol/L) for 24 hours, the expression of miR-217 in HA-VSMCs and rat aortic VSMCs was not altered. Intriguingly, the expression of NMDAR mRNA and protein was reduced by homocysteine in a dose-dependent manner. Transfection of miR-217 mimic significantly inhibited the proliferation and migration of VSMCs with homocysteine treatment, while transfection of miR-217 inhibitor promoted VSMCs migration. Moreover, miR-217 mimic down-regulated while miR-217 inhibitor up-regulated NMDAR protein expression but not NMDAR mRNA expression. Through luciferase reporter assay, we showed that miR-217 could directly bind to the 3'-UTR of NMDAR. MiR-217 mimic transfection also released the inhibition of cAMP-response element-binding protein (CREB)-PGC-1α signalling induced by homocysteine. Additionally, restoration of PGC-1α expression via AdPGC-1α infection markedly suppressed VSMCs proliferation through the degradation of NADPH oxidase (NOX1) and reduction of reactive oxygen species (ROS). Collectively, our study identified the role of miR-217 in regulating VSMCs proliferation and migration, which might serve as a target for atherosclerosis therapy.

  4. 75 FR 59327 - Seventh Meeting-RTCA Special Committee 217: Joint With EUROCAE WG-44 Terrain and Airport Mapping...

    Science.gov (United States)

    2010-09-27

    ... be addressed within the appropriate Working Group. Not every Working Group will be required to... RTCA SC-217/EUROCAE WG-44. Friday, October 29th. D-Taxi Coordination Report (Tiger Team). Andre Bourdais to report on the Tiger Team activities with Eurocae WG-78 (assisted by his co-chair). This will be...

  5. Mandibulofacial Dysostosis in a Patient with a de novo 2;17 Translocation that Disrupts the HOXD Gene Cluster

    OpenAIRE

    2007-01-01

    Treacher Collins syndrome is the prototypical mandibulofacial dysostosis syndrome, but other mandibulofacial dysostosis syndromes have been described. We report an infant with mandibulofacial dysostosis and an apparently balanced de novo 2;17 translocation. She presented with severe lower eyelid colobomas requiring skin grafting, malar and mandibular hypoplasia, bilateral microtia with external auditory canal atreasia, dysplastic ossicles, hearing loss, bilateral choanal stenosis, cleft palat...

  6. 48 CFR 653.217-70 - DOS form DS-1921, Award/Modification of Interagency Acquisition Agreement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false DOS form DS-1921, Award... Regulations System DEPARTMENT OF STATE CLAUSES AND FORMS FORMS Prescription of Forms 653.217-70 DOS form DS-1921, Award/Modification of Interagency Acquisition Agreement. As prescribed in 617.504-70(b)(5)(i), DS...

  7. Clinical feature analysis on 217 patients with subjective tinnitus%217例主观性耳鸣的临床特征分析

    Institute of Scientific and Technical Information of China (English)

    陈玲; 杨海弟; 区永康

    2011-01-01

    目的 研究分析耳鸣患者的临床特征及听力学特点,比较不同类型耳鸣的掩蔽试验效果,探索耳鸣的个性化治疗.方法 对我科门诊及住院的主观性耳鸣患者217例,常规病史调查,同时行纯音测听、耳声发射、耳鸣检测及掩蔽,分析耳鸣患者的临床特征,评估各类耳鸣掩蔽试验的情况.结果 耳鸣在人群高发年龄段为36~ 55岁,占24%.男女比例分别为48%及52%,耳鸣发生侧别以左侧最常见(42%),双侧耳鸣次之(30%),右侧耳鸣最少(28%).城市人口及脑力劳动者居多,分别占77%和68%.病程中以慢性耳鸣患者(病程>1年)最多(占46%).耳鸣高频及低频耳鸣患者掩蔽最为有效,有效率分别为71.6%及73.6%,而中频耳鸣掩蔽有效率仅有52.2%,夫特曼曲线类型与掩蔽试验阳性率明显相关,由Ⅰ型掩蔽阳性率为89%降至Ⅴ型掩蔽阳性率为11.7%.结论 耳鸣患者各项特征与掩蔽试验、耳鸣频率等有较大相关性,可作为耳鸣治疗效果的预测指标.Feldman曲线类型在耳鸣诊断和治疗方面有很大应用价值及指导意义,是预测耳鸣掩蔽是否有效的一个重要指标,也是选择耳鸣个体化治疗的一个重要参考依据.%Objective To analysis the clinical feature and audiology feature of patients with subjective tinnitus,compare masking,screening effectiveness of various kinds tinnitus,and search for the individual treatment ways for subjective tinnitus.Methods 217 patients in our hospistor were performed pure tone test,DPOAE,tinnitus determination,and tinnitus masking including pitch matching,intensity matching,Feldmann masking curve,and residual inhibition test with TinniTestTM.Results The prevalence rate is higher in female (52%).Tinnitts occur to the left side more common (42%),followed by bilateral ears (30%) and the right side (28%).The urban population ( 77% ) and mental worker ( 68% ) were primary in patients.The patients

  8. 47 CFR 95.217 - (R/C Rule 17) May I operate my R/C station transmitter by remote control?

    Science.gov (United States)

    2010-10-01

    ... transmitter by remote control? 95.217 Section 95.217 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... control? (a) You may not operate an R/C transmitter by radio remote control. (See R/C Rule 12, § 95.212.) (b) You may operate an R/C transmitter by wireline remote control if you obtain specific approval in...

  9. Use of a genetically enhanced, pediocin-producing starter culture, Lactococcus lactis subsp. lactis MM217, to control Listeria monocytogenes in cheddar cheese

    NARCIS (Netherlands)

    Buyong, N; Kok, J; Luchansky, JB

    1998-01-01

    Cheddar cheese was prepared with Lactococcus lactis subsp, lactis MM217, a starter culture which contains pMC117 coding for pediocin PA-1, About 75 liters of pasteurized milk (containing ca, 3.6% fat) was inoculated with strain MM217 (ca, 10(6) CFU per ml) and a mixture of three Listeria monocytogen

  10. Factors Associated with Coronary Artery Disease in Young Population (Age≤40):Analysis with 217 Cases

    Institute of Scientific and Technical Information of China (English)

    Wei-xian Yang; Zheng Yang; Yong-jian Wu; Shu-bin Qiao; Yue-jin Yang; Ji-lin Chen

    2014-01-01

    Objective To investigate the relevant factors of coronary artery disease (CAD) in young people under 40 years of age. Methods The study population was 292 young patients accepting coronary angiography in Fuwai Hospital from July to December 2006, including 272 men and 20 women, with the mean age being 36.7±3.7 years. The diagnosis of CAD was made in the cases presenting ≥50%stenosis in coronary lumen in coronary angiography. Based on the diagnosis, 217 patients (204 men, 13 women) were assigned to CAD group, and 75 (68 men, 7 women) to non-CAD group. Clinical data and metabolic characteristics of the patients were collected and analyzed using t-test,χ2 test, and multinomial logistic regression with SPSS 8.0 software. Results Most study subjects were current smokers (209/292, 71.6%), and more than half had body mass index (BMI)>24 kg/m2 (230/292, 78.8%) and usually took high-fat diet (162/292, 55.5%). The proportion of heavy smokers (smoking history ≥10 years and ≥20 cigarettes per day) were significantly higher in the CAD group than in the non-CAD group [20.7%(45/217) vs. 9.3%(7/75), P=0.015)]. Heavy smoking [odds ratio (OR), 1.89;95%confidence interval (CI), 1.74-2.05], hypertension (OR, 1.56;95%CI, 1.48-1.65), alcohol (OR, 1.37;95%CI, 1.30-1.46), type 2 diabetes mellitus (OR, 1.37;95%CI, 1.25-1.50), high-fat diet (OR, 1.35;95% CI, 1.28-1.43), and BMI>24 kg/m2 (OR, 1.09;95% CI, 1.03-1.17) were factors related to CAD in the young patients (all P Conclusions Heavy smoking, hypertension, alcohol consumption, type 2 diabetes mellitus, high-fat diet and BMI>24 kg/m2 were significantly related to CAD in patients aged ≤ 40, with heavy smoking presenting the highest OR. Metabolic syndrome and inflammation were also more common in young CAD patients than in non-CAD patients.

  11. Reasons for rejection of food items in Swedish families with children aged 2-17.

    Science.gov (United States)

    Koivisto, U K; Sjödén, P O

    1996-02-01

    The aims of the study were to investigate family members' reasons for rejection of foods served in the family, the reasons for not serving specific foods, children's reasons for liking/disliking foods and the use of parental mealtime practices to encourage child eating. Also, the relationships between child/parental neophobia and (1) the reasons for not serving specific foods and (2) the use of mealtime practices were studied. A group of randomly selected families (n = 370) with children aged 2-17 years from two Swedish towns (stratified, 185 from each) were invited and 57 participated. The results are based on an ad hoc food-frequency questionnaire, a mealtime-practices questionnaire, the Food and Neophobia Scale (Pliner & Hobden, 1992), parental ratings of child food neophobia and on a child interview. The main reason for family members rejecting the foods and the main reason for children's dislikes was "distaste". The most frequent reason for children's likings was "good taste". The most frequent reasons for not serving the specific foods were "distaste", the "food did not occur to me", "seasonal/availability" and "habit". The mothers' total Food Neophobia score was significantly correlated with "did not occur to me". Parental ratings of child food neophobia were significantly correlated with mealtime-practice factors "postpone meals" and "child decides portion".

  12. Na1.67Mn2.17(MoO43

    Directory of Open Access Journals (Sweden)

    Chahira Bouzidi

    2014-04-01

    Full Text Available The title compound, disodium dimanganese(II tris[orthomolybdate(VI], was prepared by solid-state reactions. The structure can be described as being composed of Mn2Mo2O14 double-chains that are interconnected by corner-sharing with MoO4 tetrahedra, leading to a three-dimensional framework with channels propagating in [100] and [001] in which the Na+ counter-cations are located. One of these Na sites is located on an inversion centre, one is partially occupied [occupancy 0.341 (9], and one is statistically occupied by Na and Mn in a ratio of 0.829 (5:0.171 (5. Na1.67Mn2.17(MoO43 is isotypic with structures of the Ag2M2(MoO43 (M = Zn, Mg, Co, Mn family. A comparative structural description is provided between the structure of the title compound and those of related phases containing (MXO8n chains (M = Mo, Mn and X = As or M2O10 (M = Mo, Mn, Nb, V dimers.

  13. Doxylamine pharmacokinetics following single dose oral administration in children ages 2-17 years.

    Science.gov (United States)

    Balan, Guhan; Thompson, Gary A; Gibb, Roger; Li, Lijuan; Hull, David; Seeck, Molly

    2013-11-01

    To characterize doxylamine pharmacokinetics in children. This study was conducted in 41 subjects, ages 2-17 years. Doxylamine succinate doses based on age/weight ranged from 3.125 to 12.5 mg. A single oral dose was administered with 2 to 4 oz. of water or decaffeinated beverages ∼2 hours after a light breakfast. Plasma samples were obtained before and for 72 hours after dosing and analyzed for doxylamine using HPLC MS/MS. Pharmacokinetic parameters were estimated using non-compartmental methods and relationships with age were assessed using linear regression. Over the fourfold dose range, Cmax was similar while AUC increased only 60%, although not statistically significant (P-value = 0.0517). As expected due to increasing body size, CLo and Vz /F increased with age. Due to a similar increase with age for Clo and Vz /F, no age-related differences in t1/2,z were observed (∼16 hours). Allometric scaling indicated no maturation related changes in CLo ; although Vz /F remained age-dependent, the predicted range decreased ∼70%. Overall, the single doses were well tolerated. Somnolence was the most common reported AE with no apparent differences in incidence noted with age. An age/weight dosing nomogram utilizing a fourfold range of doses achieves similar Cmax , whereas AUC increases only 60%.

  14. BXERL photo-injector based on a 217 MHz normal conducting RF gun

    Institute of Scientific and Technical Information of China (English)

    LIU Sheng-Guang; HUANG Tong-Ming; XU Jin-Qiang

    2011-01-01

    The Beijing X-ray Energy Recovery Linac(BXERL)test facility is proposed in Institute of High Physics(IHEP).In this proposal,the main linac requires the injector to provide an electron beam with 5 MeV energy and 10 mA average current.An injector based on DC gun technology is the first candidate electron source for BXERL.However,the field emission in the DC gun cavity makes it much more difficult to increase the high voltage to more than 500 kV.Another technology based on a 217 MHz normal conducting RF gun is proposed as the backup injector for this test facility.We have designed this RF gun with 2D SUPERFISH code and 3D MICROWAVE STUDIO code.In this paper,we present the optimized design of the gun cavity,the gun RF parameters and the set-up of the whole injector system.The detailed beam dynamics have been done and the simulation results show that the injector can generate electron bunches with RMS normalizedemittance 1.0 πmm.mrad,bunch length 0.77 mm,beam energy 5.0 MeV and energy spread 0.60%.

  15. [Cervical cancer. Epidemiological profile in 1,217 patients. Seguro popular].

    Science.gov (United States)

    Torres Lobatón, Alfonso; Bustamante Iglesias, José Israel; Torres Rojo, Alfonso; Oliva Posada, Juan Carlos; Morales Palomares, Miguel Angel; Román Bassaure, Edgar

    2013-02-01

    Cervical cancer is the most common and most lethal gynecological cancer in Mexico. To show epidemiological aspects of patients with cervical cancer treated at General Hospital of Mexico with Seguro Popular (free of cost health plan). A retrospective, observational and descriptive study of files from patients with cervical cancer treated at General Hospital of Mexico, from January 2005 to December 2008. We attended 1,217 patients, 69% of them came from some state of the country; 725 (59%) only had basic studies and 181 (15%) didn't study; 692 (57%) had their first intercourse before 18 years old; 772 (63%) had more than three children and 629 (55%) never had made a cervical cytology; 1,090 (89%) had diagnosis of squamous cell carcinoma and 127 (11%) adenocarcinomas; 990 (81%) were invasive carcinomas and 227 (19%) in situ; 580 patients (51%) had FIGO stages 0 and I, and 555 (49%) stages II-IV. For stages 0, the median age was 35 years, for stage I, 42 years; 50 years for stage II, 54 for stage III and 51 for stage IV. This study showed that 69% of the patients came from some state of the country, a frequency of carcinomas in situ lesser than reported at other series in this country and 49% of advanced stages. Most patients had risk factors reported for this disease.

  16. RANS based CFD methodology for a real scale 217-pin wire-wrapped fuel assembly of KAERI PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Jae-Ho, E-mail: jhjeong@kaeri.re.kr [Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseoung-gu, Daejeon (Korea, Republic of); Song, Min-Seop [Department of Nuclear Engineering, Seoul National University, 559 Gwanak-ro, Gwanak-gu, Seoul (Korea, Republic of); Lee, Kwi-Lim [Korea Atomic Energy Research Institute, 989-111 Daedeok-daero, Yuseoung-gu, Daejeon (Korea, Republic of)

    2017-03-15

    Highlights: • This paper presents a suitable way for a practical RANS based CFD methodology which is applicable to real scale 217-pin wire-wrapped fuel assembly of KAERI PGSFR. • A key point of differentiation of the RANS based CFD methodology in this study is adapting an innovative grid generation method using a fortran based in-house code with a GGI function in a general-purpose commercial CFD code, CFX. • The RANS based CFD methodology is implemented with high resolution scheme and SST turbulence model in the 7-pin 37-pin, and 127-pin wire-wrapped fuel assembly of PNC and JNC. Furthermore, the RANS based CFD methodology can be successfully extended to the real scale 217-pin wire-wrapped fuel bundles of KAERI PGSFR. • Three-dimensional thermal-hydraulic characteristics have been also investigated briefly. - Abstract: This paper presents a suitable way for a practical RANS (Reynolds Averaged Navier-Stokes simulation) based CFD (Computational Fluid Dynamics) methodology which is applicable to real scale 217-pin wire-wrapped fuel assembly of KAERI (Korea Atomic Energy Research Institute) PGSFR (Prototype Gen-IV Sodium-cooled Fast Reactor). The main purpose of the current study is to support license issue for the KAERI PGSFR core safety and to elucidate thermal-hydraulic characteristics in a 217-pin wire-wrapped fuel assembly of KAERI PGSFR. A key point of differentiation of the RANS based CFD methodology in this study is adapting an innovative grid generation method using a fortran based in-house code with a GGI (General Grid Interface) function in a general-purpose commercial CFD code, CFX. The innovative grid generation method with GGI function can achieve to simulate a real wire shape with minimizing cell skewness. The RANS based CFD methodology is implemented with high resolution scheme in convection term and SST (Shear Stress Transport) turbulence model in the 7-pin 37-pin, and 127-pin wire-wrapped fuel assembly of PNC (Power reactor and Nuclear fuel

  17. Magnetic Microstructures of 2:17 Type Sm(Co,Fe,Cu,Zr)z Magnets Detected by Magnetic Force Microscopy

    Institute of Scientific and Technical Information of China (English)

    Xia Ailin; Guo Zhaohui; Li Wei; Han Baoshan

    2006-01-01

    The magnetic microstructures of 2:17 type Sm(Co,Fe,Cu,Zr)z magnets were detected by magnetic force microscopy.Comparing the microstructures of the specimens coated with and without Ta thin film before and after heat-treatment, it is found that: (a) as a protection layer, Ta coating layer about 20 nm thick can effectively restrain Sm volatilization under high temperature;(b) the stress built in the 2:17 type Sm-Co magnets during specimen preparation only affects some local parts of the domain structures;(c) the magnetic microstructures vary largely for specimens heat-treated at high temperature without Ta film coating due to Sm volatilization.In addition, by comparing with high coercivity Fe-Pt point tips, it is found that the Co-Cr thin-film tips are not suitable for detecting the magnetic microstructures of strong permanent magnets.

  18. A computer program to generate equations of motion matrices, L217 (EOM). Volume 1: Engineering and usage

    Science.gov (United States)

    Kroll, R. I.; Clemmons, R. E.

    1979-01-01

    The equations of motion program L217 formulates the matrix coefficients for a set of second order linear differential equations that describe the motion of an airplane relative to its level equilibrium flight condition. Aerodynamic data from FLEXSTAB or Doublet Lattice (L216) programs can be used to derive the equations for quasi-steady or full unsteady aerodynamics. The data manipulation and the matrix coefficient formulation are described.

  19. Bloodstream infection following 217 consecutive systemic-enteric drained pancreas transplants

    Directory of Open Access Journals (Sweden)

    Mark Walter

    2006-08-01

    Full Text Available Abstract Background Combined kidney pancreas transplantation (PTx evolved as excellent treatment for diabetic nephropathy. Infections remain common and serious complications. Methods 217 consecutive enteric drained PTxs performed from 1997 to 2004 were retrospectively analyzed with regard to bloodstream infection. Immunosuppression consisted of antithymocyteglobuline induction, tacrolimus, mycophenolic acid and steroids for the majority of cases. Standard perioperative antimicrobial prophylaxis consisted of pipercillin/tazobactam in combination with ciprofloxacin and fluconazole. Results One year patient, pancreas and kidney graft survival were 96.4%, 88.5% and 94.8%, surgical complication rate was 35%, rejection rate 30% and rate of infection 59%. In total 46 sepsis episodes were diagnosed in 35 patients (16% with a median onset on day 12 (range 1–45 post transplant. Sepsis source was intraabdominal infection (IAI (n = 21, a contaminated central venous line (n = 10, wound infection (n = 5, urinary tract infection (n = 2 and graft transmitted (n = 2. Nine patients (4% experienced multiple episodes of sepsis. Overall 65 pathogens (IAI sepsis 39, line sepsis 15, others 11 were isolated from blood. Gram positive cocci accounted for 50 isolates (77%: Coagulase negative staphylococci (n = 28, i.e. 43% (nine multi-resistant, Staphylococcus aureus (n = 11, i.e. 17% (four multi-resistant, enterococci (n = 9, i.e. 14% (one E. faecium. Gram negative rods were cultured in twelve cases (18%. Patients with blood borne infection had a two year pancreas graft survival of 76.5% versus 89.4% for those without sepsis (p = 0.036, patient survival was not affected. Conclusion Sepsis remains a serious complication after PTx with significantly reduced pancreas graft, but not patient survival. The most common source is IAI.

  20. Wittgenstein y la familiaridad de lo humano. Una critica a la interpretacion convencionalista de IF [seccion][seccion]185-217

    National Research Council Canada - National Science Library

    Perez Cortes, Adriana Carolina

    2013-01-01

    ...]185-217 de las Investigaciones filosoficas en los que muestra que hay casos en los que el significado de expresiones como "seguir una regla" y "contravenirla" no se determina solamente apelando...

  1. Reaction natYb+48Ca->217Th+3n: auto calibration process for DSSSD detector application (particular case)

    CERN Document Server

    Tsyganov, Yu

    2015-01-01

    The Dubna Gas-Filled Recoil Separator (DGFRS) is the mostly effective setup in use for the field of synthesis of superheavy elements. Application of DSSSD detector provides more precise energy and position detection for both implanted recoils and their alpha decays. To minimize contribution of background products the method of fctive correlation is applied at the DGFRS. To apply this method a precise calibration for 48 front strips is strongly required. Method of three peaks auto calibration is proposed with a first approximation step with 9.26 MeV 217Th peaks. Examples of alpha-decay original spectra and spectra after filtration procedures are presented.

  2. The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M.; Gray, Joe W.; Auersperg, Nelly

    2008-04-25

    Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymorphism and Affymetrix analysis of ZNF217-overexpressing cell lines confirmed consistently increased expression of eEF1A2 but not of other oncogenes, and revealed early changes in EEF1A2 gene copy numbers and increased expression at crisis during immortalization. We defined the influence of eEF1A2 overexpression on immortalized ovarian surface epithelial cells, and investigated interrelationships between effects of ZNF217 and eEF1A2 on cellular phenotypes. Lentivirally induced eEF1A2 overexpression caused delayed crisis, apoptosis resistance and increases in serum-independence, saturation densities, and anchorage independence. siRNA to eEF1A2 reversed apoptosis resistance and reduced anchorage independence in eEF1A2-overexpressing lines. Remarkably, siRNA to eEF1A2 was equally efficient in inhibiting both anchorage independence and resistance to apoptosis conferred by ZNF217 overexpression. Our data define neoplastic properties that are caused by eEF1A2 in nontumorigenic ovarian cancer precursor cells, and suggest that eEF1A2 plays a role in mediating ZNF217-induced neoplastic progression.

  3. Magnetic domain structures of precipitation-hardened SmCo 2:17-type sintered magnets: Heat treatment effect

    Institute of Scientific and Technical Information of China (English)

    Li Xiu-Mei; Fang Yi-Kun; Guo Zhao-Hui; Liu Tao; Guo Yong-Quan; Li Wei; Han Bao-Shan

    2008-01-01

    The typical magnetic domains of Sm(CobalFe0.25Cu0.07Zr0.02)7.4 magnets quenched through various heat-treatment steps have been revealed by using magnetic force microscopy (MFM). For the specimens in which the nominal c-axis is perpendicular to the imaging plane, the domain configurations change from plate-like for the as-sintered mag-net to corrugation and spike-like for the homogenized one, and then to a coarse and finally to a finer domain structure when isothermally aged at 830℃ and then annealed at 400℃. However, only plate-like domains can be detected on the surfaces with the nominal c-axis parallel to the imaging plane. The finer domain (so-called interaction domain) is a characteristic magnetic domain pattern of the Sm-Co 2:17-type magnets with high coercivities. Domain walls in a zigzag shape are revealed by means of MFM in final bulk Sm-Co 2:17-type sintered magnets.

  4. Mandibulofacial dysostosis in a patient with a de novo 2;17 translocation that disrupts the HOXD gene cluster.

    Science.gov (United States)

    Stevenson, David A; Bleyl, Steven B; Maxwell, Teresa; Brothman, Arthur R; South, Sarah T

    2007-05-15

    Treacher Collins syndrome (TCS) is the prototypical mandibulofacial dysostosis syndrome, but other mandibulofacial dysostosis syndromes have been described. We report an infant with mandibulofacial dysostosis and an apparently balanced de novo 2;17 translocation. She presented with severe lower eyelid colobomas requiring skin grafting, malar and mandibular hypoplasia, bilateral microtia with external auditory canal atreasia, dysplastic ossicles, hearing loss, bilateral choanal stenosis, cleft palate without cleft lip, several oral frenula of the upper lip/gum, and micrognathia requiring tracheostomy. Her limbs were normal. Chromosome analysis at the 600-band level showed a 46,XX,t(2;17)(q24.3;q23) karyotype. Sequencing of the entire TCOF1 coding region did not show evidence of a sequence variation. High-resolution genomic microarray analysis did not identify a cryptic imbalance. FISH mapping refined the breakpoints to 2q31.1 and 17q24.3-25.1 and showed the 2q31.1 breakpoint likely affects the HOXD gene cluster. Several atypical findings and lack of an identifiable TCOF1 mutation suggest that this child has a provisionally unique mandibulofacial dysostosis syndrome. The apparently balanced de novo translocation provides candidate loci for atypical and TCOF1 mutation negative cases of TCS. Based on the agreement of our findings with one previous case of mandibulofacial dysostosis with a 2q31.1 transocation, we hypothesize that misexpression of genes in the HOXD gene cluster produced the described phenotype in this patient.

  5. 结节性甲状腺肿外科治疗217例分析

    Institute of Scientific and Technical Information of China (English)

    庞辉

    2010-01-01

    目的 探讨结节性甲状腺肿外科治疗的时机、方法和效果.方法 回顾分析217例结节性甲状腺肿手术病人临床资料.结果 217例全部手术治疗,单纯手术治愈170例(78.3%),手术+替代治疗治愈38例(17.5%),复发9例(4.2%),总治愈率95.8%.结论 结节性甲状腺肿外科治疗效果应以提高手术技巧为主,在完全切除结节前提下,尽可能保留正常腺体,合理替代治疗术后甲状腺功能低下.

  6. Roflumilast: APTA 2217, B9302-107, BY 217, BYK 20869.

    Science.gov (United States)

    2004-01-01

    Roflumilast [APTA 2217, B9302-107, BY 217, BYK 20869] is a selective phosphodiesterase IV inhibitor. It is being developed by Altana Pharma (formerly Byk Gulden), a subsidiary of Altana Group, as an orally administered therapy for asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis and psoriasis. The drug is awaiting regulatory approval in Europe for the treatment of asthma and COPD. Byk Gulden has stated that roflumilast relieves asthma symptoms through both an anti-inflammatory effect and a muscle relaxant effect. Roflumilast has potential as first-line long-term therapy in mild-to-moderate COPD and as additive long-term therapy in moderate-to-severe COPD. Altana has stated that roflumilast is to be marketed under the brand name Daxas. Altana Group and Pharmacia Corporation (now Pfizer) signed an agreement on 22 April 2002 to collaborate on the development and commercialisation of roflumilast for the treatment of respiratory disorders, including asthma and COPD. The companies will jointly develop the drug for the US, Europe and other markets. Pharmacia will co-ordinate development in the US and Altana will co-ordinate development in Europe. After approval of the drug, Pharmacia and Altana will jointly launch and promote roflumilast in the US, Europe and elsewhere. Altana will receive an upfront payment and additional milestone payments. Altana additionally has the option to co-promote Pharmacia products in the US and elsewhere. On 16 April 2003, Pharmacia Corporation was acquired by, and merged into, Pfizer. In November 2002, Altana and Tanabe Seiyaku signed an agreement to collaborate on the development and commercialisation of roflumilast for the treatment of respiratory diseases, including asthma and COPD. Tanabe Seiyaku and Altana will develop roflumilast for asthma and COPD in Japan, and will jointly launch and co-promote roflumilast in Japan following regulatory approval. Roflumilast has been in multinational phase III clinical studies

  7. 我院2009-2013年药品不良反应报告217例分析%Analysis of adverse reactions of drugs in our hospital from 2009 to 2013:on 217 cases report

    Institute of Scientific and Technical Information of China (English)

    卿常春; 罗锡; 黄春玲

    2014-01-01

    目的:了解该院药品不良反应( ADR)发生的特点及规律,掌握ADR事件发生的特点并制定相应对策,减少ADR事件的伤害。方法2009年1月-2013年11月上报ADR 217例,按性别、年龄、药物制剂、药品种类、给药途径、ADR累积器官或系统及临床表现等方面进行回顾性分析统计。结果217例ADR报告中,静脉滴注给药引发的ADR报告比例最高,占85.25%;涉及药品品种以抗菌药物为首,占38.71%;ADR累计器官或系统主要为皮肤系统,临床表现以皮疹、瘙痒、潮红、红斑为主。结论重视医院开展ADR监测工作,加强相关培训,提高医务人员上报意识,利于为调整医院用药方式及筛选用药品种提供理论依据,确保用药安全。%Objective To investigate the characteristics and general features of adverse drug reactions ( ADR ) oc-curred in our hospital for reference of clinical rational drug administration and to develop better countermeasures ,reducing the ADR event of injury.Methods Retrospectively analyzed the 217 cases ADR reports,collected from January 2009 to November 2013 in the hospital,by gender,age,drug formulations,variety of drugs,route of administration,organs and system related to ADR,clinical manifestations and other aspects .Results Among 217 cases of ADR reports ,the highest proportion of ADR re-ports was caused by administered intravenously , accounting for 85.25%;The ADR induced by antimicrobial drugs was the higheat,accounting for 38.71%;The organ or system related to ADR was skin systems ,the mainly clinical manifestations were skin rash,itching,flushing and erythema .Conclusion It is right to emphasize the ADR monitoring and improve the conscious-ness in order to ensure the clinical rational drug administration .ADR monitoring work carried out in the hospital ,help to pro-vide a theoretical basis for the adjustment of hospital medication and screening of drug varieties , to ensure

  8. Swedish parents' activities together with their children and children's health: a study of children aged 2-17 years.

    Science.gov (United States)

    Berntsson, Leeni T; Ringsberg, Karin C

    2014-11-01

    Nordic children's health has declined. Studies show that parents' engagement in children's leisure-time activities might provide beneficial health outcomes for children. The aim of the present study was to examine the association between Swedish parents' activities together with their children, the parents' experiences of time pressure and their children's health. Data of 1461 Swedish children aged 2-17 years old that were collected in the NordChild study of 2011 were used. We analyzed physical health, diseases and disabilities, psychosomatic health and well-being, and the parents' experiences of time pressure; and we calculated the associations between parental activity together with the child and health indicators. Activities that were significantly and positively associated with children's health at ages 2-17 years of age were: playing and playing games; going to the cinema, theatre, and sporting events; reading books; playing musical instruments/singing; sports activities; watching TV/video/DVD. Playing video games or computer games, driving child to activities and going for walks were significantly and positively associated at age groups 7-12 years and 13-17 years. Activities that were negatively associated with health were: surfing/blogging on the Internet, going shopping and doing homework. Parents who were not experiencing time pressures had a higher level of activity together with their children. The parental experience of time pressure was associated with work time, with less homework activity and more symptoms in children. The family and home are important settings for the development of children's health we found eight parental activities together with their children that promoted the children's health parents' working time and their time pressure experiences affected their activities with their children there is a need for an increased focus on parental activities that are positively associated with children's health. © 2014 the Nordic Societies of

  9. Microstructural changes during the slow-cooling annealing of nanocrystalline SmCo 2:17 type magnets

    Energy Technology Data Exchange (ETDEWEB)

    Romero, S.A. [Instituto de Fisica da Universidade de Sao Paulo, Sao Paulo (Brazil); Escola Politecnica da Universidade de Sao Paulo, Sao Paulo (Brazil); Campos, M.F. de, E-mail: mcampos@metal.eeimvr.uff.br [PUVR - Universidade Federal Fluminense, Av. dos Trabalhadores 420, Vila Santa Cecilia, Volta Redonda, RJ 27255-125 (Brazil); Castro, J.A. de [PUVR - Universidade Federal Fluminense, Av. dos Trabalhadores 420, Vila Santa Cecilia, Volta Redonda, RJ 27255-125 (Brazil); Moreira, A.J. [Escola Politecnica da Universidade de Sao Paulo, Sao Paulo (Brazil); Landgraf, F.J.G. [Escola Politecnica da Universidade de Sao Paulo, Sao Paulo (Brazil); Instituto de Pesquisas Tecnologicas do Estado de Sao Paulo, Sao Paulo (Brazil)

    2013-02-25

    Highlights: Black-Right-Pointing-Pointer Use of the Stoner-Wohlfarth Callen Liu Cullen model in 2:17 type magnets. Black-Right-Pointing-Pointer Data suggest exchange coupling between Sm2(CoFe)17 and Sm(CoCu)5 phases. Black-Right-Pointing-Pointer It is given structural data for phase Sm0.33Zr0.67TM3, with TM=Co,Fe,Cu. Black-Right-Pointing-Pointer The beneficial effect of the slow cooling treatment is explained. - Abstract: The microstructure and magnetic properties of 2:17 type isotropic magnets were investigated. The slow cooling heat treatment (cooling at 1 Degree-Sign C/min from 820 to 400 Degree-Sign C, and isothermal treatment during 24 h) was interrupted after the temperatures of 820, 700, 600 and 500 Degree-Sign C and their hysteresis were measured with fields up to 9 T. The fully heat treated sample presented coercivity ({mu}{sub 0}H) of 3.32 T, after 24 h at 400 Degree-Sign C. The microstructure was investigated with SEM-FEG (Scanning Electron Microscope with Field Emission Gun) and X-ray Diffraction Rietveld analysis. The application of the Stoner-Wohlfarth-Callen-Liu-Cullen (SW-CLC) model points out exchange coupling between ferromagnetic Sm{sub 2}(CoFe){sub 17} nanocells and ferromagnetic Sm(CoCu){sub 5} present at the cell boundary phase. The results are interpreted with the double shell model: first-a cobalt-rich ferromagnetic Sm(CoCu){sub 5} shell originates exchange coupling and second-a copper-rich paramagnetic Sm(CuCo){sub 5} shell produces magnetic decoupling. This double shell helps to maximize coercivity and remanence. The anisotropy field of the Sm{sub 2}(CoFe){sub 17} cell phase was estimated in 7 T with the SW-CLC model.

  10. Activation of Na(+)-K(+)-ATPase with DRm217 attenuates oxidative stress-induced myocardial cell injury via closing Na(+)-K(+)-ATPase/Src/Ros amplifier.

    Science.gov (United States)

    Yan, Xiaofei; Xun, Meng; Dou, Xiaojuan; Wu, Litao; Zhang, Fujun; Zheng, Jin

    2017-04-01

    Reduced Na(+)-K(+)-ATPase activity has close relationship with cardiomyocyte death. Reactive oxygen species (ROS) also plays an important role in cardiac cell damage. It has been proved that Na(+)-K(+)-ATPase and ROS form a feed-forward amplifier. The aim of this study was to explore whether DRm217, a proved Na(+)/K(+)-ATPase's DR-region specific monoclonal antibody and direct activator, could disrupt Na(+)-K(+)-ATPase/ROS amplifier and protect cardiac cells from ROS-induced injury. We found that DRm217 protected myocardial cells against hydrogen peroxide (H2O2)-induced cardiac cell injury and mitochondrial dysfunction. DRm217 also alleviated the effect of H2O2 on inhibition of Na(+)-K(+)-ATPase activity, Na(+)-K(+)-ATPase cell surface expression, and Src phosphorylation. H2O2-treatment increased intracellular ROS, mitochondrial ROS and induced intracellular Ca(2+), mitochondrial Ca(2+) overload. DRm217 closed Na(+)-K(+)-ATPase/ROS amplifier, alleviated Ca(2+) accumulation and finally inhibited ROS and mitochondrial ROS generation. These novel results may help us to understand the important role of the Na(+)-K(+)-ATPase in oxidative stress and oxidative stress-related disease.

  11. Utilization of Skills in the Care of the Patient with Common, Well-Defined Health Deviations I (NS 217): Competency-Based Course Syllabus.

    Science.gov (United States)

    Green, Elizabeth G.; Yates, Laura H.

    "Utilization of Skills in the Care of the Patient with Common, Well-Defined Health Deviations I" (NS 217) is an associate degree nursing course offered at Chattanooga State Technical Community College to help students develop new competencies necessary for the care of patients with deviations of the cardiovascular, endocrine, integumentary, and…

  12. The Planck-ATCA Co-eval Observations (PACO) project: analysis of radio source properties between 5 and 217 GHz

    CERN Document Server

    Massardi, Marcella; Bonavera, Laura; De Zotti, Gianfranco; Lopez-Caniego, Marcos; Galluzzi, Vincenzo

    2015-01-01

    The Planck-ATCA Co-eval Observations (PACO) project has yielded observations of 464 sources with the Australia Telescope Compact Array (ATCA) between 4.5 and 40 GHz. The main purpose of the project was to investigate the spectral properties of mm-selected radio sources at frequencies below and overlapping with the ESA's Planck satellite frequency bands, minimizing the variability effects by observing almost simultaneously with the first two Planck all-sky surveys. In this paper we present the whole catalogue of observations in total intensity. By comparing PACO with the various measures of Planck Catalog of Compact Sources (PCCS) flux densities we found the best consistency with the PCCS "detection pipeline" photometry (DETFLUX) that we used to investigate the spectral properties of sources from 5 to 217 GHz. Of our sources, 91% have remarkably smooth spectrum, well described by a double power law over the full range. This suggests a single emitting region, at variance with the notion that "flat" spectra resu...

  13. VizieR Online Data Catalog: HK photometry in an UCHII region near Sh2-217 (Brand+, 2011)

    Science.gov (United States)

    Brand, J.; Massi, F.; Zavagno, A.; Deharveng, L.; Lefloch, B.

    2010-11-01

    Coordinates and photometric parameters (magnitudes and colours) are presented of the stars located in a molecular condensation on the SW-border of the Galactic HII region Sh2-217. The data were obtained on January 4, 2004 with the 3.58-m Telescopio Nazionale Galileo (TNG; La Palma, Canary Islands, Spain). Near-infrared observations were carried out through H and K' broad-band filters with the camera NICS. The image scale is 0.25arcsec/pixel, yielding a field of view of about 4.2'x4.2'. Observing strategy and exposure times are described in Deharveng et al. (2006A&A...458..191D), the only difference being that the dithering sequence for the H-band images was the same as adopted for K'. The data reduction steps adopted are outlined in Deharveng et al. (2006A&A...458..191D). Aperture photometry was done using the DAOPHOT package in IRAF. We followed the same procedure described in Deharveng et al. (2006A&A...458..191D) to obtain aperture photometry, after which PSF-fitting photometry was performed. Although the seeing was good (image of a sample of stars and fitting those positions to the equatorial coordinates given by Deharveng et al. (2006A&A...458..191D), using tasks of STSDAS/IRAF. The typical accuracy of this procedure is of the order of 1". (1 data file).

  14. Status of the 7 MeV/u, 217 MHz Injector Linac for the Heidelberg Cancer Therapy Facility

    CERN Document Server

    Schlitt, B; Hutter, G; Klos, F; Lu, Y; Minaev, S A; Mühle, C; Ratzinger, U; Schlitt, B; Tiede, R; Vinzenz, W; Will, C; Zurkan, O

    2004-01-01

    A clinical synchrotron facility for cancer therapy using energetic proton and ion beams (C, He and O) is under construction and will be installed at the Radiologische Universitätsklinik in Heidelberg, Germany, starting in 2005. The status of the ECR ion source systems, the beam line components of the low energy beam transport lines, the 400 keV/u RFQ and the 20 MV IH-cavity as well as the linac rf system will be reported. Two prototype magnets of the linac quadrupole magnets have been built at GSI and have been tested successfully. A test bench for the 1.4 MW, 217 MHz cavity amplifier built by industry has been installed at GSI including a 120 kW driver amplifier which will be used also for high power tests of the RFQ. A test bench for the RFQ using proton beams is presently being set up at the IAP. RF tuning of the 1:2 scaled IH-DTL model as well as Microwave Studio simulations of the model and the power cavity have been also performed at the IAP [1].

  15. Exchange of glutamine-217 to glutamate of Clostridium limosum exoenzyme C3 turns the asparagine-specific ADP-ribosyltransferase into an arginine-modifying enzyme.

    Science.gov (United States)

    Vogelsgesang, Martin; Aktories, Klaus

    2006-01-24

    C3-like ADP-ribosyltransferaseses are produced by Clostridium species, Bacillus cereus, and various Staphylococcus aureus strains. The exoenzymes modify the low-molecular-mass GTPases RhoA, B, and C. In structural studies of C3-like exoenzymes, an ARTT-motif (ADP-ribosylating turn-turn motif) was identified that appears to be involved in substrate specificity and recognition (Han, S., Arvai, A. S., Clancy, S. B., Tainer, J. A. (2001) J. Mol. Biol. 305, 95-107). Exchange of Gln217, which is a key residue of the ARTT-motif, to Glu in C3 from Clostridium limosum results in inhibition of ADP-ribosyltransferase activity toward RhoA. The mutant protein is still capable of NAD-binding and possesses NAD+ glycohydrolase activity. Whereas recombinant wild-type C3 modifies Rho proteins specifically at an asparagine residue (Asn41), Gln217Glu-C3 is capable of ADP-ribosylation of poly-arginine but not poly-asparagine. Soybean trypsin inhibitor, a model substrate for many arginine-specific ADP-ribosyltransferases, is modified by the Gln217Glu-C3 transferase. Also in C3 ADP-ribosyltransferases from Clostridium botulinum and B. cereus, the exchange of the equivalent Gln residue to Glu blocked asparagine modification of RhoA but elicited arginine-specific ADP-ribosylation. Moreover, the Gln217Glu-C3lim transferase was able to ADP-ribosylate recombinant wild-type C3lim at Arg86, resulting in decrease in ADP-ribosyltransferase activity of the wild-type enzyme. The data indicate that the exchange of one amino acid residue in the ARTT-motif turns the asparagine-modifying ADP-ribosyltransferases of the C3 family into arginine-ADP-ribosylating transferases.

  16. Investigating the effects of 217 Hz frequency of cell phone on learning and spatial memory in rats

    Directory of Open Access Journals (Sweden)

    Kohzad S

    2013-03-01

    Full Text Available Background: Extremely low frequency (0-300 Hz fields from power lines, electronic equipment and medical devices, have been reported to produce various biological effects. Global system for mobile (GSM is most largely used in everybody's life. This system utilizes a low frequency band as well as a high frequency range of electromagnetic field. This study investigated the effects of 217 Hz electromagnetic field (the modulating signal in GSM on spatial learning and memory in rat.Methods: Twenty four male Wistar rat (200- 250 g were randomly divided in to three groups as: test, sham and control. Using a Helmholtz coil system, the test group was exposed to a uniform pulsed EMF of 200 µT (micro Tesla intensity for 4 h/day for 21 days (2 time in a day. This procedure was repeated for the sham group but with no field. All groups were trained prior to the day 21 on the 15th day for five days four trial per day in Morris Water-Maze system. Then the probe test was carried out for 60 seconds with no platform.Results: The ANOVA test revealed that no significant differences were found between control and exposed rats in all day of learning acquisition. Also, in probe test for investigating the memory, no significant differences observed. (P≤0.05 is accepted for significant level.Conclusion: This finding is in consistent with previous studies and indicates low frequency band of electromagnetic fields (EMF (200 µT intensity in cell phone may not have any effect on the learning acquisition and spatial memory in rat.

  17. Comparative M-H Characteristics of 1-5 and 2-17 Type Samarium-Cobalt Permanent Magnets to 300 C

    Science.gov (United States)

    Niedra, Janis M.

    1994-01-01

    Recent consideration of the use of permanent magnets in space power converters at heat rejection temperatures exceeding 250 C and in miniature high temperature actuators is supporting a search for permanent magnets resistant to demagnetizing forces at high temperature. The present paper investigates the short-term demagnetization resistance to applied bucking fields and at temperatures up to 300 C of SmCo5 type magnets, in the form of 1-cm cubes, from several commercial sources. Quasistatic, 2nd quadrant M-H data taken at selected temperatures are the source of derived plots which are then compared to similar data for previously tested Sm2Co17 type magnets. The 1-5 magnet remanence tends to be about 1.5 kG below that of the 2-17 magnets throughout the temperature range. However, the intrinsic coercivities and M-H curve 'knee-fields' seen in particular 1-5 magnets were considerably above those seen previously in the 2-17 magnets. This superior resistance to demagnetizing fields attainable in 1-5 magnets is also illustrated by safe operating area plots based on the knee-field, the magnetic induction swing and temperature. Comments are made on the possibility that a remanence versus knee-field tradeoff can make 1-5 material competitive with 2-17 in applications where a magnet has to withstand large bucking fields at high temperature.

  18. Expression of mRNA and protein of ZNF217 and EF1α and their significance in pathological scar%锌指基因217和翻译延伸因子1α在病理性瘢痕组织中的表达和意义

    Institute of Scientific and Technical Information of China (English)

    吴文艺; 王小影; 张丽婷; 郑志芳; 朱世泽; 王朝阳

    2012-01-01

    目的 探讨锌指基因217(ZNF217)和翻译延伸因子1α(EF1α)在病理性癜痕中的表达及其相互关系,以及它们在瘢痕形成中的作用及机制,为瘢痕防治提供实验依据.方法 利用实时荧光定量聚合酶链式反应(PCR)法、蛋白质免疫印迹(Western印迹)法检测正常皮肤、成熟瘢痕、增生性瘢痕和瘢痕疙瘩组织中ZNF217和EF1α的mRNA、蛋白相对表达水平.结果 正常皮肤、成熟瘢痕、增生性瘢痕和瘢痕疙瘩组织中ZNF217的mRNA及蛋白质相对表达量分别为1.46±0.397、1.45±0.265、4.49±0.999、5.47±0.808;0.276±0.0211、0.299±0.0150、0.743±0.0509、0.747±0.0377.EF1α的mRNA及蛋白质相对表达量分别为1.47±0.469、1.47±0.218、5.10±1.680、5.74±1.920;0.505±0.0371、0.518±0.0153、0.780土0.0369、0.792±0.0290.病理性瘢痕组织中ZNF217的mRNA及蛋白质表达显著高于正常皮肤、成熟瘢痕(P<0.01);病理性瘢痕组织中EF1α的mRNA及蛋白质表达增高,与正常皮肤、成熟瘢痕对照组比较,差异有统计学意义(P<0.01);病理性瘢痕组织中ZNF217的mRNA及蛋白质表达与EF1α的mRNA及蛋白质表达呈正相关.结论 ZNF217在病理性瘢痕组织中表达增高,可能通过调节EF1α等细胞周期调控因子而促进瘢痕组织中细胞的增生,对病理性瘢痕的形成可能起着重要作用.%Objective To study the expression of ZNF217 and EF1α gene in the pathological scars and to investigate role and probable mechanism in the pathogenesis of abnormal scar.Methods Quantitative real-time PCR and Western blot were performed to detect the expression and distribution of mRNA and protein of ZNF217 and EF1α in hypertrophic scar (10 cases),keloid (10 cases),normal scar (10 cases),and normal skin (10 cases),and statistics was used to analyze the data.Results The expression of ZNF217 mRNA and protein in the normal skin,normal scar,hypertrophic scar and keloid were 1.46±0.397,1.45±0.265,4.49±0.999,5.47±0

  19. The Effect of 217 Hz Magnetic Field of Cell Phone with Different Intensities on Apoptosis of Normal and Cancerous Cells Treated with Chemotherapy Drug

    Directory of Open Access Journals (Sweden)

    Mahsa Mansourian

    2012-03-01

    Full Text Available Background: According to the increasing development of home and business electronic equipment in today's world, the biological effects of ELF magnetic fields have been studied at two molecular-cellular and animal- human levels. Considering the therapeutic viewpoint of this study regarding the effects of low-frequency fields of mobile phone, the effect of acute exposure to this field on chemotherapy will be studied.Materials and Methods: In this experimental study, based on measurement of the intensity of the magnetic fields from mobile phones in another research, flux densities of magnetic field of 159.44, 93.25 and 120µ tesla with frequency of 217Hz was generated in magnetic field generator system, and the apoptosis level in K562 cancer cells and healthy cells of lymphocytes was assessed after exposure to field using flow cytometry method. This evaluation method was also performed for the cells treated with bleomycin after exposure to this field.Results: 217 Hz magnetic field exposure significantly increases the rate of apoptosis percentage (p > 0.05 in K562 cancer cells and in two intensities of 120 and 159.44µ tesla compared to the control group, but such effect is not observed in lymphocyte cells. Bleomycin-induced apoptosis percentage following exposure to the mentioned magnetic field shows no significant difference compared to the group of treatment with drug and without field exposure. This lack of significant difference is observed between the groups of drug after field exposure and field alone as well as between groups exposed to field and groups treated with bleomycin.Conclusion: Study results showed that 217 Hz magnetic field of mobile phone can induce apoptosis on cancer cells, but it has no effect on healthy cells. Thus, in order to use mobile phone as an effective factor in their treatment, some studies should be conducted at animal-human level.

  20. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  1. Isolation of Actinium from Neutron-irradiated Thorium-I

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Isolation of Actinium from Neutron-irradiated Thorium-I¥YangWeifan;YuanShuanggui;MuWantong;ZhangXueqian;LiZhongweiandZhaoLili...

  2. ExoMol molecular line lists XIX: high-accuracy computed hot line lists for H218O and H217O

    Science.gov (United States)

    Polyansky, Oleg L.; Kyuberis, Aleksandra A.; Lodi, Lorenzo; Tennyson, Jonathan; Yurchenko, Sergei N.; Ovsyannikov, Roman I.; Zobov, Nikolai F.

    2017-04-01

    Hot line lists for two isotopologues of water, H218O and H217O, are presented. The calculations employ newly constructed potential energy surfaces (PES), which take advantage of a novel method for using the large set of experimental energy levels for H216O to give high-quality predictions for H218O and H217O. This procedure greatly extends the energy range for which a PES can be accurately determined, allowing an accurate prediction of higher lying energy levels than are currently known from direct laboratory measurements. This PES is combined with a high-accuracy, ab initio dipole moment surface of water in the computation of all energy levels, transition frequencies and associated Einstein A coefficients for states with rotational excitation up to J = 50 and energies up to 30 000 cm-1. The resulting HotWat78 line lists complement the well-used BT2 H216O line list. Full line lists are made available online as Supporting Information and at www.exomol.com.

  3. Role of the non-opioid dynorphin peptide des-Tyr-dynorphin (DYN-A(2-17)) in food intake and physical activity, and its interaction with orexin-A.

    Science.gov (United States)

    Gac, L; Butterick, T A; Duffy, C M; Teske, J A; Perez-Leighton, C E

    2016-02-01

    Food intake and physical activity are regulated by multiple neuropeptides, including orexin and dynorphin (DYN). Orexin-A (OXA) is one of two orexin peptides with robust roles in regulation of food intake and spontaneous physical activity (SPA). DYN collectively refers to several peptides, some of which act through opioid receptors (opioid DYN) and some whose biological effects are not mediated by opioid receptors (non-opioid DYN). While opioid DYN is known to increase food intake, the effects of non-opioid DYN peptides on food intake and SPA are unknown. Neurons that co-express and release OXA and DYN are located within the lateral hypothalamus. Limited evidence suggests that OXA and opioid DYN peptides can interact to modulate some aspects of behaviors classically related to orexin peptide function. The paraventricular hypothalamic nucleus (PVN) is a brain area where OXA and DYN peptides might interact to modulate food intake and SPA. We demonstrate that injection of des-Tyr-dynorphin (DYN-A(2-17), a non opioid DYN peptide) into the PVN increases food intake and SPA in adult mice. Co-injection of DYN-A(2-17) and OXA in the PVN further increases food intake compared to DYN-A(2-17) or OXA alone. This is the first report describing the effects of non-opioid DYN-A(2-17) on food intake and SPA, and suggests that DYN-A(2-17) interacts with OXA in the PVN to modulate food intake. Our data suggest a novel function for non-opioid DYN-A(2-17) on food intake, supporting the concept that some behavioral effects of the orexin neurons result from combined actions of the orexin and DYN peptides.

  4. Estimate of the anisotropy field in isotropic SmCo 2:17 magnets with the Stoner-Wohlfarth CLC model

    Energy Technology Data Exchange (ETDEWEB)

    De Campos, M F [PUVR- Universidade Federal Fluminense, Av dos Trabalhadores 420, Vila Santa Cecilia, Volta Redonda, RJ, 27255-125 (Brazil); Romero, S A [Instituto de Fisica, Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Landgraf, F J G [Escola Politecnica, Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Missell, F P, E-mail: fmissell@yahoo.com, E-mail: mcampos@metal.eeimvr.uff.br [Centro de Ciencias Exatas e Tecnologia, Universidade de Caxias do Sul, Caxias do Sul, RS, 95070-560 Brazil (Brazil)

    2011-07-06

    The Callen-Liu-Cullen (CLC) modification of the Stoner-Wohlfarth model was found able to describe properly the hysteresis curves of isotropic Sm(CoFeCuZr)z magnets. The SW-CLC model uses three parameters, and all of them have physical meaning. One of the parameters is related to the saturation magnetization, another to the anisotropy field, and another is 1/d, which evaluates the interaction between grains or particles. The model was applied for several magnets, indicating an anisotropy field of 6-7 T, which is compatible with other methods for anisotropy field determination. The model also gives insight into the abnormal temperature dependence of the coercivity found in SmCo 2:17 magnets. For compositions with a low z, the parameter 1/d is significant. These compositions with a low z are those showing the most abnormal coercivity behavior with temperature.

  5. Pre-eruptive conditions of dacitic magma erupted during the 21.7 ka Plinian event at Nevado de Toluca volcano, Central Mexico

    Science.gov (United States)

    Arce, J. L.; Gardner, J. E.; Macías, J. L.

    2013-01-01

    The Nevado de Toluca volcano in Central Mexico has been active over the last ca. 42 ka, during which tens of km3 of pyroclastic material were erupted and two important Plinian-type eruptions occurred at ca. 21.7 ka (Lower Toluca Pumice: LTP) and ca. 10.5 ka (Upper Toluca Pumice: UTP). Samples from both the LTP and UTP contain plagioclase, amphibole, iron-titanium oxides, and minor anhedral biotite, set in a vesicular, rhyolitic, glassy matrix. In addition, UTP dacites contain orthopyroxene. Analysis of melt inclusions in plagioclase phenocrysts yields H2O contents of 2-3.5 wt.% for LTP and 1.3-3.6 wt.% for UTP samples. Ilmenite-ulvospinel geothermometry yields an average temperature of ~ 868 °C for the LTP magma (hotter than the UTP magma, ~ 842 °C; Arce et al., 2006), whereas amphibole-plagioclase geothermometry yields a temperature of 825-859 °C for the LTP magma. Water-saturated experiments using LTP dacite suggest that: (i) amphibole is stable above 100 MPa and below 900 °C; (ii) plagioclase crystallizes below 250-100 MPa at temperatures of 850-900 °C; and (iii) pyroxene is stable only below pressures of 200-100 MPa and temperatures of 825-900 °C. Comparison of natural and experimental data suggests that the LTP dacitic magma was stored at 150-200 MPa (5.8-7.7 km below the volcano summit). No differences in pressure found between 21.7 ka and 10.5 ka suggest that these two magmas were stored at similar depths. Orthopyroxene produced in lower temperature LTP experiments is compositionally different to those found in UTP natural samples, suggesting that they originated in two different magma batches. Whole-rock chemistry, petrographic features, and mineral compositions suggest that magma mixing was responsible for the generation of the dacitic Plinian LTP eruption.

  6. La metáfora de la gestación y del parto al servicio de la analogía. Una lectura de Sal 2,1-7. [Reseña

    OpenAIRE

    Heras-Oliver, G. (Gloria)

    2004-01-01

    Reseña de Lourdes GARCÍA UREÑA, La metáfora de la gestación y del parto al servicio de la analogía. Una lectura de Sal 2,1-7, Pontificia Universidad de la Santa Cruz, Roma 2003, 280 pp., 17 x 24, ISBN 88-8333-071-4.

  7. Effect of Sm-rich liquid phase on magnetic properties and microstructures of sintered 2:17-type Sm-Co magnet

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wenchen; ZHAO Rui; FANG Yikun; ZHOU Mingge; ZHU Minggang; LI Wei

    2011-01-01

    The effect of Sm-rich liquid phase (Sm2Co3) on magnetic properties and microstructure of 2:17-type Sm-Co magnet was studied.Three phases existed in liquid phase ingot,and took on white,dark grey and grey,respectively.It was found that the composition of the grey area was similar to the nominal one.Our results indicated that the optimal composition was obtained at 3 wt.% liquid phase added,and the magnetic properties were Br=11.58 kGs,Hci>26 kOe,(BH)m=29.51 MGOe.Br increased by 3%,Hci was 13 times larger,and (BH)m was 6 times bigger than none liquid phase magnets.Moreover,with the aging time decreasing from 20 to 8 h,the squareness of the demagnetization curves got better,while the coercivity of the samples decreased.It revealed that Sm(Co,Cu)5 phase also precipitated at particle boundaries.It maybe also enhanced the coercivity.

  8. In-Source Laser Spectroscopy with the Laser Ion Source and Trap: First Direct Study of the Ground-State Properties of ^{217,219}Po

    Directory of Open Access Journals (Sweden)

    D. A. Fink

    2015-02-01

    Full Text Available A Laser Ion Source and Trap (LIST for a thick-target, isotope-separation on-line facility has been implemented at CERN ISOLDE for the production of pure, laser-ionized, radioactive ion beams. It offers two modes of operation, either as an ion guide, which performs similarly to the standard ISOLDE resonance ionization laser ion source (RILIS, or as a more selective ion source, where surface-ionized ions from the hot ion-source cavity are repelled by an electrode, while laser ionization is done within a radio-frequency quadrupole ion guide. The first physics application of the LIST enables the suppression of francium contamination in ion beams of neutron-rich polonium isotopes at ISOLDE by more than 1000 with a reduction in laser-ionization efficiency of only 20. Resonance ionization spectroscopy is performed directly inside the LIST device, allowing the study of the hyperfine structure and isotope shift of ^{217}Po for the first time. Nuclear decay spectroscopy of ^{219}Po is performed for the first time, revealing its half-life, α-to-β-decay branching ratio, and α-particle energy. This experiment demonstrates the applicability of the LIST at radioactive ion-beam facilities for the production and study of pure beams of exotic isotopes.

  9. Regulatory Assistance, Stakeholder Outreach, and Coastal and Marine Spatial Planning Activities In Support Marine and Hydrokinetic Energy Deployment: Task 2.1.7 Permitting and Planning Fiscal Year 2012 Year-End Report

    Energy Technology Data Exchange (ETDEWEB)

    Geerlofs, Simon H.; Hanna, Luke A.; Judd, Chaeli R.; Blake, Kara M.

    2012-09-01

    This fiscal year 2012 year-end report summarizes activities carried out under DOE Water Power task 2.1.7, Permitting and Planning. Activities under Task 2.1.7 address the concerns of a wide range of stakeholders with an interest in the development of the MHK industry, including regulatory and resource management agencies, tribes, NGOs, and industry. Objectives for 2.1.7 are the following: • To work with stakeholders to streamline the MHK regulatory permitting process. • To work with stakeholders to gather information on needs and priorities for environmental assessment of MHK development. • To communicate research findings and directions to the MHK industry and stakeholders. • To engage in spatial planning processes in order to further the development of the MHK industry. These objectives are met through three subtasks, each of which are described in this report: • 2.1.7.1—Regulatory Assistance • 2.1.7.2—Stakeholder Outreach • 2.1.7.3—Coastal and Marine Spatial Planning As the MHK industry works with the regulatory community and stakeholders to plan, site, permit and license MHK technologies they have an interest in a predictable, efficient, and transparent process. Stakeholders and regulators have an interest in processes that result in sustainable use of ocean space with minimal effects to existing ocean users. Both stakeholders and regulators have an interest in avoiding legal challenges by meeting the intent of federal, state, and local laws that govern siting and operation of MHK technologies. The intention of work under 2.1.7 is to understand these varied interests, explore mechanisms to reduce conflict, identify efficiencies, and ultimately identify pathways to reduce the regulatory costs, time, and potential environmental impacts associated with developing, siting, permitting, and deploying MHK systems.

  10. Analysis of 217 Strains Bacteria and their Drug Susceptibility from Hospitalized Children with Lower Respiratory Tract Infections%儿童下呼吸道感染217株细菌分析及药物敏感趋势监测

    Institute of Scientific and Technical Information of China (English)

    方敏; 何邱宁

    2012-01-01

    目的:了解儿童下呼吸道感染致病菌的流行趋势和药物敏感性,为临床合理用药提供依据.方法:对2010年3月1日~2011年8月31日在我科住院的下呼吸道感染患儿痰液标本中分离出的病原菌进行药物敏感性监测分析.结果:共分离出217株病原菌.G-杆菌以大肠埃希菌(28.11%)、解鸟氨酸克雷伯菌(7.37%)、洛菲不动杆菌(6.91%)为主;G+菌以腐生葡萄球菌(9.68%)、表皮葡萄球菌(6.45%)、金黄色葡萄球菌(3.69%)为主.G-杆菌对第三代头孢菌素中的头孢他啶、头孢吡肟、氨曲南、亚胺培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、阿米卡星等抗生素敏感性高;G+球菌对青霉素、红霉素、克林霉素及阿奇霉素耐药率高,对其他抗生素敏感.超广谱β-内酰胺酶(ESBLs)的确证试验结果:61株大肠埃希菌产酶率55.74%;21株腐生葡萄球菌、耐甲氧西林凝固酶阴性葡萄球菌(MRSCN)产酶率9.52%,14株表皮葡萄球菌MRSCN的产酶率7.14%;5株屎肠球菌高水平氨基糖苷类耐药株( HLAR)40.00%,4株粪肠球菌HLAR为25.00%.结论:加强细菌培养和耐药性监测对临床合理使用抗生素十分必要.%Objective;To investigate the trend of lower respiratory tract infections in children and drug susceptibility to provide basis for reasonable use of drugs in clinical practice. Methods; A total of 217 strains of bacteria were isolated from sputum specimen of children who were hospitalized with lower respiratory tract infections form March 2010 to August 2011 in our hospital. The bacteria were cultured with blood dish and identified. Drug susceptibility was monitored. Results; 217 strains of bacteria were isolated. The first three places of Cram-negative bacilli were Escherichia coli (28. 11%), Klebsiella omithinolytica (7.37%) and Acinetobacter lwoffi (6.91%). The first three places of Cram-positive cocci were S. saprophyticus (9. 68% ) , S. epidermidis (6

  11. Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells.

    Science.gov (United States)

    Tripathi, Shubhandra; Srivastava, Gaurava; Sharma, Ashok

    2016-08-05

    Drug resistance poses a threatening challenge for mankind, as the development of resistance to already well-established drugs causes serious therapeutic problems. Resistance to paclitaxel (Ptxl), a complex diterpenoid working as microtubule stabilizer, is one such issue in cancer treatment. Microtubule stabilizer drugs, stabilises microtubules upon binding to β-tubulin subunit of tubulin heterodimer thus causing mitotic arrest leading to death of cancer cell. Leucine point mutations viz. L215H, L217R, and L225M were reported for Ptxl resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations was explored using molecular docking, molecular dynamics (MD) simulation, binding energy estimation (MMPBSA), free energy decomposition, principle component analysis (PCA) and free energy landscape (FEL) methods. A total of five systems including unbound βI-tubulin (Apo), docked wild+Ptxl, L215H+Ptxl, L217R+Ptxl and L225M+Ptxl were prepared, and 50 ns MD simulation was performed for each system. Binding energy estimation indicated that leucine mutation reduces the binding affinity of Ptxl in mutant types (MTs) as compared to wild type (WT). Further, in contrast to WT Ptxl interactions with the M-loop (PHE270-VAL286), S6-S7 loop and H9-H10 were significantly altered in MTs. Results showed that in MTs, Ptxl had weak interaction with M-loop residues, while having strong affinity with S6-S7 loop and H6-H7 loop. Moreover, PCA and FEL analysis revealed that M-loop flexible region (THR274-LEU284) was strongly bound with Ptxl in WT preventing its flexible movement and the causing factor for microtubule stabilization. In MTs due to poor interaction with Ptxl, M-loop flexible region retains its flexibility, therefore unable to stabilize microtubule. This study will give an insight into the importance of M-loop flexible region interaction with Ptxl for microtubule stabilization. In addition, it clearly provides the molecular basis of

  12. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines

    Directory of Open Access Journals (Sweden)

    Mary J. Eaton

    2012-01-01

    Full Text Available Effective treatment of sensory neuropathies in peripheral neuropathies and spinal cord injury (SCI is one of the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal cord is a logical next step in the development of treatment modalities. But few clinical trials, especially for chronic pain, have tested the potential of transplant of cells to treat chronic pain. Cell lines derived from the human neuronal NT2 cell line parentage, the hNT2.17 and hNT2.19 lines, which synthesize and release the neurotransmitters gamma-aminobutyric acid (GABA and serotonin (5HT, respectively, have been used to evaluate the potential of cell-based release of antinociceptive agents near the lumbar dorsal (horn spinal sensory cell centers to relieve neuropathic pain after PNS (partial nerve and diabetes-related injury and CNS (spinal cord injury damage in rat models. Both cell lines transplants potently and permanently reverse behavioral hypersensitivity without inducing tumors or other complications after grafting. Functioning as cellular minipumps for antinociception, human neuronal precursors, like these NT2-derived cell lines, would likely provide a useful adjuvant or replacement for current pharmacological treatments for neuropathic pain.

  13. Comment on “Stratigraphy, petrography and dispersion of the lower Permian syn-eruptive deposits in the Viar Basin, Spain” by S. Sierra, C. Moreno and E. Pascual [Sedimentary Geology 217 (2009) 1-29

    Science.gov (United States)

    Wagner, R. H.; Mayoral, E.

    2010-07-01

    Comments are provided on a published paper on "Lower Permian" strata in SW Spain [S. Sierra, C. Moreno and E. Pascual, Stratigraphy, petrography and dispersion of the lower Permian syn-eruptive deposits in the Viar Basin, Spain, Sedimentary Geology 217 (2009) 1-29], which failed to take into account up-to-date information on this most southerly occurrence in western Europe. This generally lacustrine basin commenced with valley fill deposits in a deeply incised palaeotopography and contains mainly red beds with two basaltic intervals and a major acidic volcanic episode linked to a nearby volcanic centre to the Northeast. The stratigraphic succession shows southeasterly onlap. Although a syn-sedimentary fault has been postulated on the NE basin margin, the field evidence disproves this notion as well as the assumption that this "Early Permian" basin would have been controlled by a rejuvenated Ossa-Morena/South Portuguese boundary fault. In fact, this basin lies within the (former) area of Ossa-Morena.

  14. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  15. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  16. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  17. The release of dissolved actinium to the ocean: A global comparison of different end-members

    Science.gov (United States)

    Geibert, W.; Charette, M.; Kim, G.; Moore, W.S.; Street, J.; Young, M.; Paytan, A.

    2008-01-01

    The measurement of short-lived 223Ra often involves a second measurement for supported activities, which represents 227Ac in the sample. Here we exploit this fact, presenting a set of 284 values on the oceanic distribution of 227Ac, which was collected when analyzing water samples for short-lived radium isotopes by the radium delayed coincidence counting system. The present work compiles 227Ac data from coastal regions all over the northern hemisphere, including values from ground water, from estuaries and lagoons, and from marine end-members. Deep-sea samples from a continental slope off Puerto Rico and from an active vent site near Hawaii complete the overview of 227Ac near its potential sources. The average 227Ac activities of nearshore marine end-members range from 0.4??dpm m- 3 at the Gulf of Mexico to 3.0??dpm m- 3 in the coastal waters of the Korean Strait. In analogy to 228Ra, we find the extension of adjacent shelf regions to play a substantial role for 227Ac activities, although less pronounced than for radium, due to its weaker shelf source. Based on previously published values, we calculate an open ocean 227Ac inventory of 1.35 * 1018??dpm 227Acex in the ocean, which corresponds to 37??moles, or 8.4??kg. This implies a flux of 127??dpm m-2 y- 1 from the deep-sea floor. For the shelf regions, we obtain a global inventory of 227Ac of 4.5 * 1015??dpm, which cannot be converted directly into a flux value, as the regional loss term of 227Ac to the open ocean would have to be included. Ac has so far been considered to behave similarly to Ra in the marine environment, with the exception of a strong Ac source in the deep-sea due to 231Paex. Here, we present evidence of geochemical differences between Ac, which is retained in a warm vent system, and Ra, which is readily released [Moore, W.S., Ussler, W. and Paull, C.K., 2008-this issue. Short-lived radium isotopes in the Hawaiian margin: Evidence for large fluid fluxes through the Puna Ridge. Marine Chemistry]. Another potential mechanism of producing deviations in 227Ac/228Ra and daughter isotope ratios from the expected production value of lithogenic material is observed at reducing environments, where enrichment in uranium may occur. The presented data here may serve as a reference for including 227Ac in circulation models, and the overview provides values for some end-members that contribute to the global Ac distribution. ?? 2007 Elsevier B.V. All rights reserved.

  18. Novel deletion and a new missense mutation (Glu 217 Lys) at the catalytic site in two adenosine deaminase alleles of a patient with neonatal onset adenosine deaminase severe combined immunodeficiency

    Energy Technology Data Exchange (ETDEWEB)

    Hirschhorn, R.; Nicknam, M.N.; Eng, F.; Yang, D.R.; Borkowsky, W. (New York Univ. Medical School of Medicine, NY (United States))

    1992-11-01

    Mutations at the adenosine deaminase (ADA) locus result in a spectrum of disorders, encompassing a fulminant neonatal onset severe combined immunodeficiency (SCID) and childhood onset immunodeficiency, as well as apparently normal immune function. The extent of accumulation of the toxic metabolite, deoxyATP, correlates directly with severity of disease. The authors have now determined the mutations on both alleles of a child with fulminant, neonatal onset ADA SCID and accumulation of extremely high concentrations of deoxyATP. The genotype was consistent with the severely affected phenotype. One allele carried a large deletion that arose by non-homologous recombination and included the first five exons and promoter region. The second allele carried a missense mutation (G[sup 649]A) resulting in replacement of Glu[sup 217], an amino acid involved in the catalytic site, by Lys and predicting a major alteration in charge. Expression of the mutant cDNA on Cos cells confirmed that the mutation abolished enzyme activity. The authors have previously reported that a missense mutation at the preceding codon is similarly associated with neonatal onset ADA SCID and accumulation of extremely high deoxyATP. These findings suggest that genotype-phenotype correlations may be apparent for ADA SCID, despite the role that random variation in exposure to environmental pathogens may play in the initial phenotype. Such genotype-phenotype correlations may be important to consider in evaluating results of ongoing trials of [open quotes]gene[close quotes] and enzyme replacement therapy. 50 refs., 5 figs., 2 tabs.

  19. Reference: 217 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available al. 2005 Jun. Plant J. 42(5):743-56. Fusion of the egg and the sperm cells in plants produces a zygote that ...utant phenotype, suggesting a functional conservancy but a structural divergence through evolution. Although...yos including putative embryogenic cells. FAC1, therefore, represents one of the earliest expressed genes kn...own in plants. It may act through AMP depletion to provide sufficient energy for the zygote to proce

  20. 12 CFR 217.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... that is considered to be a deposit under § 204.2(a) of the Board's Regulation D—Reserve Requirements of... bank under § 204.2(o) of the Board's Regulation D—Reserve Requirements of Depository Institutions (12... Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM PROHIBITION AGAINST THE...

  1. 20 CFR 498.217 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... value is substantially outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or needless presentation of cumulative evidence. (d) Although relevant,...

  2. 22 CFR 217.14 - Preemployment inquiries.

    Science.gov (United States)

    2010-04-01

    ...) The recipient states clearly on any written questionnaire used for this purpose or makes clear orally if no written questionnaire is used that the information requested is intended for use solely...

  3. 50 CFR 217.204 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ...) prior to using an impact hammer. (7) In-water impact pile driving shall not occur during the period from..., respectively. If a marine mammal is detected within or approaching a distance 200 m from in-water pile driving or in-water chipping, operations shall be immediately delayed or suspended until the marine...

  4. 8 CFR 217.2 - Eligibility.

    Science.gov (United States)

    2010-01-01

    ..., Brunei, Czech Republic, Denmark, Estonia, Finland, France, Germany, Hungary, Iceland, Ireland, Italy... provisions of this part notwithstanding the fact that the required consent of the Attorney General may have...

  5. 14 CFR 217.1 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... persons transported with the object of providing relief in cases of general epidemic, natural disaster, or... promotional offers (for example two-for-one) or loyalty programs (for example, redemption of frequent flyer...

  6. 48 CFR 217.7003 - Purchase request.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Exchange of Personal... economic advantage indicating— (1) The anticipated economic advantage to the Government from use of the... value). ...

  7. 22 CFR 217.44 - Academic adjustments.

    Science.gov (United States)

    2010-04-01

    ... effective methods of making orally delivered materials available to students with hearing impairments..., individually prescribed devices, readers for personal use or study, or other devices or services of a personal...

  8. 22 CFR 217.47 - Nonacademic services.

    Science.gov (United States)

    2010-04-01

    ... placement services to its students shall provide these services without discrimination on the basis of...) Social organizations. A recipient that provides significant assistance to fraternities, sororities, or... permit discrimination otherwise prohibited by this subpart. ...

  9. 14 CFR 217.10 - Instructions.

    Science.gov (United States)

    2010-01-01

    ... required on the homeland to homeland markets, or the homeland—third country markets. QF—Qantas Airways... destination. BA—British Airways LHR—London, England ANC—Anchorage, USA NRT—Tokyo-Narita, Japan OSA—Osaka...

  10. 22 CFR 217.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... means any state or its political subdivision, any instrumentality of a state or its political... plan required to be approved by an Agency official or by a recipient as a condition to becoming a... and conditions as orthopedic, visual, speech and hearing impairments, cerebral palsy,...

  11. Adolescent Alcohol Abuse. Fastback Series No. 217.

    Science.gov (United States)

    Horton, Lowell

    This booklet examines the problem of alcohol use among American teenagers. The role that alcohol plays in adult society is presented and its potential danger for causing teenage alcohol addiction is considered. A discussion on why some teenagers abuse alcohol focuses on familial, peer, sociocultural, environmental, personality, and behavioral…

  12. 48 CFR 217.7303 - Solicitation provision.

    Science.gov (United States)

    2010-10-01

    ... information was obtained under other acquisitions); (3) The contract is for subsistence, clothing or textiles, fuels, or supplies purchased and used outside the United States; (4) The contracting officer determines...., nonrepetitive local purchases; or (5) The contracting officer determines that the exception at...

  13. 14 CFR 217.11 - Reporting compliance.

    Science.gov (United States)

    2010-01-01

    ...) Title 18 U.S.C. 1001, Crimes and Criminal Procedure, makes it a criminal offense subject to a maximum... REGULATIONS REPORTING TRAFFIC STATISTICS BY FOREIGN AIR CARRIERS IN CIVILIAN SCHEDULED, CHARTER,...

  14. 22 CFR 217.13 - Employment criteria.

    Science.gov (United States)

    2010-04-01

    ..., the test results accurately reflect the applicant's or employee's job skills, aptitude, or whatever... criteria. (a) A recipient may not make use of any employment test or other selection criterion that screens... test score or other selection criterion, as used by the recipient, is shown to be job-related for...

  15. 6 CFR 21.7 - Assurances required.

    Science.gov (United States)

    2010-01-01

    ..., COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE... give reasonable guarantee that the applicant and all recipients of Federal financial assistance...

  16. Incidence of live-attenuated influenza vaccine administration beyond expiry date in children and adolescents aged 2-17 years in the UK: a population-based cohort study.

    Science.gov (United States)

    Caspard, Herve; Wise, Robert P; Steffey, Amy; Brody, Robert S

    2017-07-17

    To estimate the proportion of live-attenuated influenza vaccine (LAIV) doses administered beyond expiry date in children and adolescents during influenza seasons 2013-2014 and 2014-2015 in the UK. This was a retrospective cohort study. Two cohorts of children and adolescents who received LAIV from 1 September 2013 to 31 March 2014 and from 1 September 2014 to 31 March 2015 and aged 2-17 years at time of LAIV administration were identified from the Clinical Practice Research Datalink (CPRD). More than 500 primary care practices in the UK. Proportions of vaccine doses administered beyond expiry date were assessed among 47 396 and 67 099 LAIV recipients with a documented vaccine lot identifier in influenza seasons 2013-2014 and 2014-2015, respectively. None. Administrations of expired LAIV were ascertained by comparison of vaccination dates in CPRD records with expiration dates in AstraZeneca/MedImmune lot distribution data. Overall, 245 LAIV recipients, 80 in 2013-2014 and 165 in 2014-2015, received a dose after its expiration date, yielding proportion estimates of 1.7 per 1000 doses (95% CI 1.3 to 2.1) in season 2013-2014 and 2.5 per 1000 (95% CI 2.1 to 2.8) in season 2014-2015. This proportion increased above 1.0% after December during each season. Most (84% in influenza season 2013-2014 and 59% in influenza season 2014-2015) received an expired dose expiration date. The proportion was higher in London (relative risk 1.93 (95% CI 1.25 to 2.99)) and when the number of LAIV recipients registered in the practice was lower than the median number per practice (relative risk 2.69 (95% CI 1.99 to 3.62)). Administration of expired LAIV doses occurs infrequently. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  17. 49 CFR 571.217 - Standard No. 217; Bus emergency exits and window retention and release.

    Science.gov (United States)

    2010-10-01

    ... the seat faces. Passenger compartment means space within the school bus interior that is between a... required emergency exit shall be outlined around its outside perimeter with a retroreflective tape with a...

  18. Synthesis and identification of 2-(2-hydroxyethoxy)-17β-hydroxy-2,17α-dimethyl-A-nor-5α-androstane,a by-product of oxandrolone during its synthesis%氧甲氢龙合成中伴生副产物2-(2-羟基乙氧基)-17β-羟基-2,17α-二甲基-A-失碳-5α-雄甾烷的鉴定与合成

    Institute of Scientific and Technical Information of China (English)

    屈洁; 饶志威; 左文果; 赵徐波; 李宗桃

    2012-01-01

    目的 为改进氧甲氢龙的合成工艺及提高产率提供实验依据.方法 通过柱色谱、重结晶等方法分离纯化合成氧甲氢龙过程中发现的副产物,经IR、1H-NMR、3C-NMR、MS、元素分析、X-单晶衍射实验等分析手段确证副产物的化学结构;推测副产物的形成机制并按此机制合成该副产物.结果与结论 鉴定副产物为2-(2-羟基乙氧基)-17β-羟基-2,17α-二甲基-A-失碳-Sα-雄甾烷,其形成机制可能是格氏试剂形成的甲基负离子在进攻中间体(7)17位的羰基碳的同时,一部分的甲基负离子从甾体平面结构的下方进攻了2位的乙缩酮的碳原子进而生成该副产物.准确分析出副产物的化学结构及形成机制.%Oxandrolone is an anabolic hormone drug and has strong anabolic effect with no obvious andro-genic effect. In synthesizing 2,2-ethandiyldioxy-17α-methyl-A-nor-5α-androstan-17β-ol which is one of the important intermediate of oxandrolone, a by-product was separated by column chromatography. The chemical structure of this by-product was confirmed as 2-(2-hydroxyethoxy)-17β-hydroxy-2,17αdirnethyl-A-nor-5α-androstane by melting point,IR,1H-NMR,13C-NMR,MS,and elemental analysis. Then the by-product was synthesized in order to study its possible formation mechanism. The result showed that the ketal structure is cleavaged in the presence of excessive methylmagnesium iodide that attacked 2-carbon when the methylmag-nesium iodide attacked 17-carbon.

  19. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  20. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  1. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  2. 5 CFR 532.217 - Appropriated fund survey jobs.

    Science.gov (United States)

    2010-01-01

    ... Air Conditioning Mechanic 10 Rigger 10 Trailer Truck Driver 8 Tool Crib Attendant 6 Painter (Finish) 9... Laundry Worker 1 Food Service Worker 2 Cook 8 (e) A lead agency must obtain prior approval of OPM to add a...

  3. 29 CFR 1910.217 - Mechanical power presses.

    Science.gov (United States)

    2010-07-01

    ... readily removable by operator, so as to minimize the possibility of misuse or removal of essential parts... application of all operators' controls to activate the slide. The removal of a hand from any control button... reduce the possibility of unintended and uncontrolled press strokes caused by bearing seizure. (5)...

  4. 34 CFR 685.217 - Teacher loan forgiveness program.

    Science.gov (United States)

    2010-07-01

    ... Consolidation Loans or Direct Consolidation Loans. The forgiveness program is only available to a borrower who... borrower— (A) Demonstrated knowledge and teaching skills in reading, writing, mathematics, and other areas...'s disabilities and who has demonstrated knowledge and teaching skills in the content areas of the...

  5. 78 FR 217 - Shared Responsibility for Employers Regarding Health Coverage

    Science.gov (United States)

    2013-01-02

    ... negative impact on employees who are on longer paid leaves, such as maternity or paternity leave. In... leave two payroll periods per year unassigned, requiring the arbitrary assignment of those two extra..., incapacity (including disability), layoff, jury duty, military duty or leave of absence (29 CFR 2530.200b-2(a...

  6. 50 CFR 216.217 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ..., and any other Federal, state or local agency with regulatory authority over the offshore oil-and-gas... During Offshore Structure Removal Operations on the Outer Continental Shelf in the U.S. Gulf of Mexico... aircraft. Observations are to start at the removal site and proceed leeward and outward of wind and...

  7. 217 | Page A JURISPRUDENCE OF THE RULE OF LAW: AN ...

    African Journals Online (AJOL)

    Fr. Ikenga

    What was the case had been an irregular rise and fall of the rule of law. .... absolute supremacy or predominance of regular law as opposed to the influence of ..... fair and public trial without undue delay; rational and proportionate approach to.

  8. 7 CFR 2.17 - Under Secretary for Rural Development.

    Science.gov (United States)

    2010-01-01

    ... government finance; income development strategies; housing; social services and utilization; adjustments to...)), related to mixed funding agreements. (19) With respect to facilities and activities under his or her... Cooperative Marketing Act of 1926 (7 U.S.C. 451-457). (xiii) Carry out the responsibilities of the...

  9. Dicty_cDB: SHH217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1 Dictyostelium discoideum H6 gene mRNA. 131 4e-31 2 BI863585 |BI863585.1 kx46a06.y1 Parastrongyloides... trichosuri FL pAMP1 v1 Chiapelli McCarter Parastrongyloides trichosuri cDNA 5' similar... to SW:EF2_CAEEL P29691 ELONGATION FACTOR 2 ;, mRNA sequence. 66 3e-19 4 BI863575 |BI863575.1 kx45h07.y1 Parastrongyloides... trichosuri FL pAMP1 v1 Chiapelli McCarter Parastrongyloides tricho...ngyloides trichosuri FL pAMP1 v1 Chiapelli McCarter Parastrongyloides trichosuri cD

  10. 36 CFR 2.17 - Aircraft and air delivery.

    Science.gov (United States)

    2010-07-01

    ... superintendent, or to landings due to circumstances beyond the control of the operator. (c)(1) Except as provided... as a part of these regulations. (e) The operation or use of hovercraft is prohibited. (f)...

  11. 14 CFR 217.6 - Extension of filing time.

    Science.gov (United States)

    2010-01-01

    ...) ECONOMIC REGULATIONS REPORTING TRAFFIC STATISTICS BY FOREIGN AIR CARRIERS IN CIVILIAN SCHEDULED, CHARTER... Director, Office of Airline Information. (b) The extension request must be received at the address provided...

  12. 14 CFR 217.9 - Waivers from reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... PROCEEDINGS) ECONOMIC REGULATIONS REPORTING TRAFFIC STATISTICS BY FOREIGN AIR CARRIERS IN CIVILIAN SCHEDULED... initiative, or upon the submission of a written request of the air carrier to the Director, Office of Airline...

  13. 1935 15' Quad #217 Aerial Photo Mosaic Index - AZ

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  14. Dicty_cDB: CHD217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available isozyme 3 mRNA, complete cds. 58 2e-07 2 CK273593 |CK273593.1 EST719671 potato abiotic stress cDNA library ... An expressed sequence tag database for abiotic stressed leaves of Vitis vinifera...6D06_332552 An expressed sequence tag database for abiotic stressed leaves of Vitis vinifera var. Chardonnay...214.1 VVB158G03_410335 An expressed sequence tag database for abiotic stressed leaves of Vitis vinifera var.

  15. 20 CFR 217.9 - Effective period of application.

    Science.gov (United States)

    2010-04-01

    ... spouse, remarried widow(er), or surviving child. (3) Application for spouse annuity filed simultaneously... within two years after the death of the employee. This period may be extended under the Soldiers' and... after the death of the person entitled to the annuity. This period may be extended under the Soldiers...

  16. Dicty_cDB: VFN217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available e lnsniyi*ii*kwtvkmfkl*lsitvlvcvkpvllvmmphvlfshqllvvqdtlvlwsvw vkkthm*vmkpnqrevs*psntqlntvslptgmiwkksgiilstm...kmfkl*lsitvlvcvkpvllvmmphvlfshqllvvqdtlvlwsvw vkkthm*vmkpnqrevs*psntqlntvslptgmiwkksgiilstmnsvlpqkntqfs*lk p

  17. Dicty_cDB: VHN217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 25 ) Dictyostelium discoideum cDNA clone:ddv50l04, 3' ... 1094 0.0 3 ( BJ442653 )... Dictyostelium discoideum cDNA clone:ddv50f18, 3' ... 1076 0.0 4 ( BJ445359 ) Dictyostelium discoideum cDNA ...clone:ddv59a09, 3' ... 1007 0.0 3 ( BJ442499 ) Dictyostelium discoideum cDNA clone:ddv50g01, 3' ... 999 0.0

  18. Dicty_cDB: VHF217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Dictyostelium discoideum cDNA clone:ddv50j21, 5' ... 100 3e-17 1 ( BJ423810 ) Di...ctyostelium discoideum cDNA clone:ddv50a16, 5' ... 100 3e-17 1 ( BJ423633 ) Dictyostelium discoideum cDNA cl

  19. 48 CFR 52.217-2 - Cancellation Under Multiyear Contracts.

    Science.gov (United States)

    2010-10-01

    ... shall be considered a termination under the Termination for Convenience of the Government clause. (c) If... it as if the claim were being made under the Termination for Convenience of the Government clause of... services which are multiyear requirements; (2) Allocable portions of the costs of facilities acquired...

  20. 18 CFR 157.217 - Changes in rate schedules.

    Science.gov (United States)

    2010-04-01

    ... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL... authorization. The certificate holder is authorized to permit an existing customer, at the customer's request... limitations on deliveries to the customer under both rate schedules are not increased, for either annual...

  1. Dicty_cDB: VHO217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CF828602 |CF828602.1 UCRCR01_01N10_r Clementine Mandarin Albedo at Rind Separation cDNA Library Citrus retic...R01_01H10_r Clementine Mandarin Albedo at Rind Separation cDNA Library Citrus reticulata cDNA clone CR_CEa01...28476.1 UCRCR01_01K07_r Clementine Mandarin Albedo at Rind Separation cDNA Library Citrus reticulata cDNA cl

  2. 48 CFR 3052.217-94 - Lay days (USCG).

    Science.gov (United States)

    2010-10-01

    ... when the vessel remains on the dry dock or marine railway as a result of any change that involves work... compensation for all costs, direct and indirect, to reimburse the Contractor for use of dry dock or marine...

  3. 48 CFR 3052.217-91 - Performance (USCG).

    Science.gov (United States)

    2010-10-01

    ... personnel of the vessel while in dry dock or on a marine railway, sanitary lavatory and similar facilities... gangways from the pier, dry dock, or marine railway to the vessel; (3) Treat salvage, scrap or other ship's... near the site of the work for the Government's use. (d) The contract will state whether dock and sea...

  4. 48 CFR 1252.217-75 - Lay days.

    Science.gov (United States)

    2010-10-01

    ... contract when the vessel remains on the dry dock or marine railway as a result of any change that involves... compensation for all costs, direct and indirect, to reimburse the Contractor for use of dry dock or marine...

  5. 48 CFR 252.217-7012 - Liability and insurance.

    Science.gov (United States)

    2010-10-01

    ...) The Contractor shall not make any allowance in the job order price for the inclusion of any premium... of and shall not affect the pricing structure of the contract, and are additional to the compensation...

  6. 48 CFR 1252.217-76 - Liability and insurance.

    Science.gov (United States)

    2010-10-01

    ...) The Contractor shall not make any allowance in the contract price for the inclusion of any premium... of and shall not affect the pricing structure of the contract, and are additional to the compensation...

  7. 48 CFR 3052.217-95 - Liability and insurance (USCG).

    Science.gov (United States)

    2010-10-01

    ... inclusion of any premium expense or charge for any reserve made on account of self-insurance for coverage... of and shall not affect the pricing structure of the contract, and are additional to the compensation...

  8. 217 L'entourage d'un Fait d'expression Comme Guide a la ...

    African Journals Online (AJOL)

    Ike Odimegwu

    ... devant des choix à faire mais l'entourage d'un fait d'expression aide le traducteur à ... context, situation of communication, gestures, facial expressions and intonation ..... Ottawa : Presse de l'université d'Ottawa, 2e édition, 1982. Jakobson ...

  9. 217. Experiencia en asistencia circulatoria mecánica en nuestro centro

    Directory of Open Access Journals (Sweden)

    J. Otero

    2012-04-01

    Conclusiones: Dada la gravedad de estos pacientes, con mortalidad cercana al 100% sin asistencia, consideramos el beneficio que aporta esta técnica y la gran utilidad que representa su disponibilidad.

  10. 14 CFR 93.217 - Allocation of slots for international operations and applicable limitations.

    Science.gov (United States)

    2010-01-01

    ... required by bilateral agreement and only for scheduled service unless the requesting carrier qualifies for...) If required by bilateral agreement, additional slots shall be allocated at LaGuardia Airport for... the same airport in a different hour or half-hour period if the trade is for the purpose of conducting...

  11. Session 21.7 - Education Programs Promoting Light Pollution Awareness and IYL2015

    Science.gov (United States)

    Walker, Constance E.

    2016-10-01

    By proclaiming the IYL2015, the United Nations recognized the importance of light and light based technology in the lives of the citizens of the world and for the development of global society on many levels. Light and application of light science and technology are vital for existing and future advances in many scientific areas and culture. Light is a key element in astronomy: as astronomers, it is what we study and makes our science possible, but it is also what threatens our observations when it is set-off from the ground (light pollution). The UN-designated year 2015 represented a magnificent and unique opportunity for the global astronomical community to disseminate these messages and raise the awareness of the importance and preservation of dark skies for heritage and the natural environment. As such, the International Year of Light served as a launching pad for several projects during 2015. Two other projects with equally as impressive programs are highlighted and begin the narrative for this section on public education and outreach programs on light pollution issues and solutions.

  12. 47 CFR 51.217 - Nondiscriminatory access: Telephone numbers, operator services, directory assistance services...

    Science.gov (United States)

    2010-10-01

    ... be provided in a timely fashion. (iii) Format. A LEC shall provide access to its directory assistance... to allow competing providers full use of these services. (d) Branding of operator services...

  13. 18 CFR 2.17 - Price discrimination and anticompetitive effect (price squeeze issue).

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Price discrimination... discrimination and anticompetitive effect (price squeeze issue). To implement compliance with the Supreme Court... interested person may file petitions to intervene alleging price discrimination and anticompetitive...

  14. WE-E-217BCD-02: Update on the Upcoming ACR Digital Mammography QC Manual.

    Science.gov (United States)

    Berns, E

    2012-06-01

    We propose a new metric called Distance Discordance (DD), which is defined as the distance between two anatomic points from two moving images, which are co-located on some reference image, when deformed onto another reference image. To demonstrate the concept of DD, we created a reference software phantom which contains two objects. The first object (1) consists of a hollow box with a fixed size core and variable wall thickness. The second object (2) consists of a solid box of fixed size and arbitrary location. 7 different variations of the fixed phantom were created. Each phantom was deformed onto every other phantom using two B-Spline DIR algorithms available in Elastix and Plastimatch. Voxels were sampled from the reference phantom [1], which were also deformed from moving phantoms [2…6], and we find the differences in their corresponding location on phantom [7]. Each voxel results in a distribution of DD values, which we call distance discordance histogram (DDH). We also demonstrate this concept in 8 Head & Neck patients. The two image registration algorithms produced two different DD results for the same phantom image set. The mean values of the DDH were slightly lower for Elastix (0-1.28 cm) as compared to the values produced by Plastimatch (0-1.43 cm). The combined DDH for the H&N patients followed a lognormal distribution with a mean of 0.45 cm and std. deviation of 0.42 cm. The proposed distance discordance (DD) metric is an easily interpretable, quantitative tool that can be used to evaluate the effect of inter-patient variability on the goodness of the registration in different parts of the patient anatomy. Therefore, it can be utilized to exclude certain images based on their DDH characteristics. In addition, this metric does not rely on 'ground truth' or the presence of contoured structures. © 2012 American Association of Physicists in Medicine.

  15. WE-E-217A-01: CAD: Quality Assurance of CAD Systems Implemented in Clinical Use.

    Science.gov (United States)

    Huo, Z

    2012-06-01

    We propose a new metric called Distance Discordance (DD), which is defined as the distance between two anatomic points from two moving images, which are co-located on some reference image, when deformed onto another reference image. To demonstrate the concept of DD, we created a reference software phantom which contains two objects. The first object (1) consists of a hollow box with a fixed size core and variable wall thickness. The second object (2) consists of a solid box of fixed size and arbitrary location. 7 different variations of the fixed phantom were created. Each phantom was deformed onto every other phantom using two B-Spline DIR algorithms available in Elastix and Plastimatch. Voxels were sampled from the reference phantom [1], which were also deformed from moving phantoms [2…6], and we find the differences in their corresponding location on phantom [7]. Each voxel results in a distribution of DD values, which we call distance discordance histogram (DDH). We also demonstrate this concept in 8 Head & Neck patients. The two image registration algorithms produced two different DD results for the same phantom image set. The mean values of the DDH were slightly lower for Elastix (0-1.28 cm) as compared to the values produced by Plastimatch (0-1.43 cm). The combined DDH for the H&N patients followed a lognormal distribution with a mean of 0.45 cm and std. deviation of 0.42 cm. The proposed distance discordance (DD) metric is an easily interpretable, quantitative tool that can be used to evaluate the effect of inter-patient variability on the goodness of the registration in different parts of the patient anatomy. Therefore, it can be utilized to exclude certain images based on their DDH characteristics. In addition, this metric does not rely on 'ground truth' or the presence of contoured structures. © 2012 American Association of Physicists in Medicine.

  16. 5 CFR 591.217 - In which outlets does OPM collect prices?

    Science.gov (United States)

    2010-01-01

    ... data collection areas, accessibility by road, physical size, advertising, and other characteristics that reflect sales volume. To the extent practical, OPM prices like items in the same types of...

  17. 25 CFR 39.217 - How are students counted for the purpose of funding residential services?

    Science.gov (United States)

    2010-04-01

    ...) Present for both the after school count and the midnight count at least one night during each week... EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Administrative Procedures, Student Counts, and... services? For a student to be considered in residence for purposes of this subpart, the school must be...

  18. 49 CFR 232.217 - Train brake tests conducted using yard air.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Train brake tests conducted using yard air. 232... Train brake tests conducted using yard air. (a) When a train air brake system is tested from a yard air... reduction of brake pipe air pressure at the same, or slower, rate as an engineer's brake valve. (b) The...

  19. 77 FR 217 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical...

    Science.gov (United States)

    2012-01-04

    ... recognize that existing HCPCS code C9716 (Creations of thermal anal lesions by radiofrequency energy) was... by Brandeis University and Mathematica Policy Research together despite their slightly differing...

  20. Progress of Recycling in the Built Environment Final report of the RILEM Technical Committee 217-PRE

    CERN Document Server

    2013-01-01

    This report is a useful tool for countries starting to recycle aggregates or construction and demolition waste. It contains the latest developments in this field, introduces a completely new approach to the procedure of proportioning concrete mixtures with recycled aggregate, references recent publications, opinions and discrepancies in relation to the durability of recycled concrete, such as freeze-thaw standards, studies of chloride penetration and diffusion, and sulfate attacks, the use of the fine fraction <4mm, quality assurance of concrete recycled aggregate, sustainability and recycling construction waste and global impact assessment of urban renewal based on sustainable recycling strategies for construction and demolition waste. This volume will be of interest to recyclers, researchers and consumers.

  1. Children of Working Mothers, March 1977. Special Labor Force Report 217.

    Science.gov (United States)

    Grossman, Allyson Sherman

    1979-01-01

    This special labor force report, focusing on children of working mothers, summarizes findings from the 1977 annual survey of marital and family characteristics of workers in the population who are 16 years old and over. Data are given on: the numbers of children of various ages with working mothers, the percentages of black and white children…

  2. 217 An International Multi-Disciplinary Journal, Ethiopia Vol. 4 (1 ...

    African Journals Online (AJOL)

    FIRST LADY

    of state actors in the international system, and the utility of military power as .... immediate environment and contribute to global peace and security, it must develop .... conflict, which might not be the case with rogue states or warlords in a failed.

  3. Q/SdR.04.896-2008 SQR7130A217/Model A Car

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    1.Background As the development of global economy demands an increasingly large quantity of energy,the energy crisis is getting more severe.Auto manufacturers in Japan,America,and Europe have all began to develop hybrid power vehicles or its technology platform since 1990s,so as to save energy.Relied on its THS system which consists of the planet wheel and e-CVT,TOYOTA developed a series of strong hybrid power vehicles,such as Prius,Lexus,Highlander,Camry,etc.Based on its IMA system,HONDA developed a series of mild hybrid power vehicles,such as Insight,Civic,Accord,etc.On the basis of its Belt-driven Starter Generator (BSG) system,French SPA Group developed a series of weak hybrid power vehicles,such as Citroen C3,Citroen C2,Citroen 1007,Citroen 207,etc.In America the research of hybrid power vehicle is being done actively by a group of relevant parties consisting of Department of Transport,Department of Defense,major auto companies and relevant organizations under the leadership of Department of Energy and with the large quantity ofinvestment from GE Motors Co.and CHRYSLER.

  4. Yeast Interacting Proteins Database: YMR159C, YBR217W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form ...d in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg1

  5. Yeast Interacting Proteins Database: YPL149W, YBR217W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a comp...ophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p... Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated A...olved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation;

  6. 48 CFR 1852.217-72 - Phased acquisition using progressive competition down-selection procedures.

    Science.gov (United States)

    2010-10-01

    .... Please note that these evaluation factors are not final, and NASA reserves the right to change them at... requirement of the Phase 1 contract. Accordingly, the costs of preparing these proposals shall not be a direct... Phase 2 will include successful completion of Phase 1 requirements. (d) NASA does not intend to issue a...

  7. Advanced Chemical Precipitation Softening. Training Module 2.217.4.77.

    Science.gov (United States)

    McMullen, L. D.

    This document is an instructional module package prepared in objective form for use by an instructor familiar with the operation and maintenance of a chemical precipitation softening system. Included are objectives, instructor guides, student handouts and transparency masters. This is the third level of a three module series. This module considers…

  8. Subtask 2.17 - CO{sub 2} Storage Efficiency in Deep Saline Formations

    Energy Technology Data Exchange (ETDEWEB)

    Gorecki, Charles; Liu, Guoxiang; Braunberger, Jason; Klenner, Robert; Ayash, Scott; Dotzenrod, Neil; Steadman, Edward; Harju, John

    2014-02-01

    As the field of carbon capture and storage (CCS) continues to advance, and large-scale implementation of geologic carbon dioxide (CO{sub 2}) storage progresses, it will be important to understand the potential of geologic formations to store meaningful amounts of CO{sub 2}. Geologic CO{sub 2} storage in deep saline formations (DSFs) has been suggested as one of the best potential methods for reducing anthropogenic CO{sub 2} emission to the atmosphere, and as such, updated storage resource estimation methods will continue to be an important component for the widespread deployment of CCS around the world. While there have been several methodologies suggested in the literature, most of these methods are based on a volumetric calculation of the pore volume of the DSF multiplied by a storage efficiency term and do not consider the effect of site-specific dynamic factors such as injection rate, injection pattern, timing of injection, pressure interference between injection locations, and overall formation pressure buildup. These volumetric methods may be excellent for comparing the potential between particular formations or basins, but they have not been validated through real-world experience or full-formation injection simulations. Several studies have also suggested that the dynamic components of geologic storage may play the most important role in storing CO{sub 2} in DSFs but until now have not directly compared CO{sub 2} storage resource estimates made with volumetric methodologies to estimates made using dynamic CO{sub 2} storage methodologies. In this study, two DSFs, in geographically separate areas with geologically diverse properties, were evaluated with both volumetric and dynamic CO{sub 2} storage resource estimation methodologies to compare the results and determine the applicability of both approaches. In the end, it was determined that the dynamic CO{sub 2} storage resource potential is timedependent and it asymptotically approaches the volumetric CO{sub 2} storage resource potential over very long periods of time in the two systems that were evaluated. These results indicate that the volumetric assessments can be used as long as the appropriate storage efficiency terms are used and it is understood that it will take many wells over very long periods of time to fully realize the storage potential of a target formation. This subtask was funded through the Energy & Environmental Research Center (EERC)– U.S. Department of Energy (DOE) Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26-08NT43291. Nonfederal funding was provided by the IEA Greenhouse Gas R&D Programme.

  9. Basic webliography on health promotion and disease prevention - doi:10.5020/18061230.2009.p217

    Directory of Open Access Journals (Sweden)

    Ana Claudia Camargo Gonçalves da Silva

    2012-01-01

    Full Text Available Objectives: To introduce a basic webliography to access highly qualified evidence-based material on health promotion and disease prevention, aiming at the continuing education of health professionals. Methods: By means of Google® browser, applying the descriptors in sequence to progressively refine the search on Internet and key concepts to be learned, all previously defined by the authors themselves, we proceeded a qualitative analyses of the 20 first listed links for each searched issue and the final selection of the most scientifically relevant ones. Results: The 34 selected links are presented in 4 groups: 23 portals, 5 guides and recommendations, 4 scientific journals and 3 blogs that allow free access to health promotion and disease prevention related subjects, such as: concepts; national and international public policies; epidemiology, statistics and health indicators; diseases screening and prophylaxis; counseling for behavior change of health related habits; and interdisciplinary work. Among the selected links 10 (29% are written in English while the others are in Portuguese. Conclusions: The identification of reading materials on health promotion and disease prevention available on Internet, many in Portuguese, allowed us to select relevant scientifically qualified literature and turn it accessible to health professionals, enabling the acquisition of new knowledge or quick update.

  10. Yeast Interacting Proteins Database: YHR171W, YBR217W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available th phosphatidylethanolamine, required steps in autophagosome formation Rows with ... of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required ste...ps in autophagosome formation Rows with this bait as bait (1) Rows with this bait a

  11. 48 CFR 1252.217-73 - Inspection and manner of doing work.

    Science.gov (United States)

    2010-10-01

    ... all times while the vessel is berthed alongside the Contractor's pier or in dry dock or on a marine... the vessel is in the custody of the Contractor or in dry dock or on a marine railway and the...

  12. 48 CFR 3052.217-92 - Inspection and manner of doing work (USCG).

    Science.gov (United States)

    2010-10-01

    ... all times while the vessel is berthed alongside the Contractor's pier or in dry dock or on a marine... the vessel is in the custody of the Contractor or in dry dock or on a marine railway and the...

  13. 48 CFR 252.217-7005 - Inspection and manner of doing work.

    Science.gov (United States)

    2010-10-01

    ... vessel at all times while the vessel is berthed alongside the Contractor's pier or in dry dock or on a..., when the vessel is in the custody of the Contractor or in dry dock or on a marine railway and the...

  14. Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution

    Science.gov (United States)

    Finn, R.; McDevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.

    2005-12-01

    In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented.

  15. Recurrent and founder mutations in the Netherlands : mutation p.K217del in troponin T2, causing dilated cardiomyopathy

    NARCIS (Netherlands)

    Otten, E.; Deprez, R. H. Lekanne Dit; Weiss, M. M.; van Slegtenhorst, M.; Joosten, M.; van der Smagt, J. J.; Kerstjens-Frederikse, W. S.; Roofthooft, M. T. R.; Balk, A. H. M. M.; van den Berg, M. P.; van Tintelen, J. P.; Ruiter, J.S.; de Jonge, N.

    2010-01-01

    Background. About 30% of dilated cardiomyopathy (DCM) cases are familial. Mutations are mostly found in the genes encoding lanain A/C, beta-myosin heavy chain and the sarcomeric protein cardiac troponin-T (TNNT2). Mutations in TNNT2 are reported in approximately 3% of DCM patients. The overall pheno

  16. In vivo emergence of Aspergillus terreus with reduced azole susceptibility and a Cyp51a M217I alteration

    DEFF Research Database (Denmark)

    Arendrup, Maiken C; Jensen, Rasmus; Grif, Katharina;

    2012-01-01

    Azole resistance in Aspergillus terreus isolates was explored. Twenty related (MB) and 6 unrelated A. terreus isolates were included. CYP51A sequencing and RAPD genotyping was performed. Five MB isolates were itraconazole susceptible, whereas the minimum inhibitory concentrations (MICs) for 15 MB...... isolates were elevated (1-2 mg/L). Voriconazole and posaconazole MICs were 0.5-4 and 0.06-0.5 mg/L, respectively, for MB isolates but 0.25-0.5 and...

  17. Ser217Cys mutation in the Ig Ⅱ domain of FGFR3 in a Chinese family with autosomal dominant achondroplasia

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shi-rong; ZHOU Xiao-qing; REN Xiang; WANG Tian-tian; YUAN Ming-xiong; WANG Qing; LIU Jing-yu; LIU Mu-gen

    2007-01-01

    @@ Achondroplasia (ACH) is the most common form of skeletal dysplasia characterized by disproportionately short stature, lumbar lordosis, relative macrocephaly and other skeletal anomalies resulting from a defect in the maturation of the chondrocytes in the growth plate of the cartilage. The combined frequency of the disease has been estimated to be 1 in 15 000 live births.1 ACH is inherited in autosomal dominant fashion with a complete penetrance, more than 80% of affected individuals have de novo mutations associated with increased paternal age.

  18. 国外新批准上市的药物新制剂新剂型(217

    Institute of Scientific and Technical Information of China (English)

    黄胜炎

    2016-01-01

    1美国FDA批准盐酸丁丙诺啡含服膜剂上市韩美国FDA批准Endo制药公司和生物释药科学国际公司联合开发的产品(商品名:Belbuca)上市,用于治疗中度至严重慢性疼痛。剂量规格:丁丙诺啡(buprenorphine)75,150,300,450,600,750和900μg/张。每张膜的剂量大小取决于制剂中丁丙诺啡的浓度和膜的表面积。

  19. 50 CFR 226.217 - Critical habitat for the Gulf of Maine Distinct Population Segment of Atlantic Salmon (Salmo salar).

    Science.gov (United States)

    2010-10-01

    ..., Northport, Searsmont, Searsport, Swanville, Waldo. (iii) Counties and towns partially or entirely within..., Oakland, Pittston, Randolph, Rome, Sidney, Vassalboro, Vienna, Waterville, West Gardiner, Windsor, Winslow... criteria for critical habitat, and those excluded under ESA section 4(b)(2): Penobscot Bay SHRU HUC 10 Code...

  20. 76 FR 6179 - Eighth Meeting-RTCA Special Committee 217: Joint With EUROCAE WG-44 Terrain and Airport Mapping...

    Science.gov (United States)

    2011-02-03

    ..., Barcelona, Spain. The contact person(s) are Maarten Uijt de Haag, Ph.D., Aerospace Research and Technology... train stops. More detailed transportation instructions and hotel information will be provided upon... Activities Working Group Read-Outs Applications Content Connectivity Guidance Quality, Non-Numeric Quality...

  1. 41 CFR 101-6.217 - Laws authorizing Federal financial assistance for programs to which this subpart applies.

    Science.gov (United States)

    2010-07-01

    ... distilled spirits, wine, and malt beverages to eleemosynary institutions (26 U.S.C. 5688). (m) Donation of..., preserving and compiling, and publishing of documentary sources significant to the history of the...

  2. 26 CFR 1.217-2 - Deduction for moving expenses paid or incurred in taxable years beginning after December 31, 1969.

    Science.gov (United States)

    2010-04-01

    ... addition, A detours into Mexico for sightseeing. Because of the stopovers and tour into Mexico, A's travel... a full-time basis as the operator of a motel both before and after the off-season. A taxpayer...

  3. Post irradiation fatigue tests of type 316 LN stainless steel. Final report for the ITER Task T511, Subtask 1. European Technology Programme Task GB5-T217

    Energy Technology Data Exchange (ETDEWEB)

    Norring, K.; Koenig, M

    2002-01-01

    The main objective of this Subtask was to estimate the corrosion fatigue behaviour of 316L Stainless Steel (SS) and SS/SS joints, and to check among others the influence of irradiation. Joints were produced by solid Hot Isostatic Pressure (HIP) and powder HIP. Conventional material was used for comparison. The specimens were supplied by EFDA and were irradiated to 4 dpa in Dimitrovgrad (Russia). All specimens were tested at 150 deg C in hydrogenated high purity water. Testing was performed with a stepwise decrease in {delta}K keeping K{sub max} constant. The crack growth rates of irradiated as well as unirradiated specimens tested earlier are of the same magnitude, around 2x10{sup -5} mm/cycle at {delta}K= 18 MPa{radical}m. Thus, irradiation does not seem to enhance the fatigue crack growth rate, at least not up to irradiation levels of 4 dpa. But it is worth noting that the exponents in the da/dN versus {delta}K equation, also known as Paris' law, seems to fall within two areas, either around 3.5 or just below 2. Both Powder HIPed and Solid HIPed specimens are found in both groups. The reason for this is not evident. The fracture surfaces of the specimens show typical fatigue appearance.

  4. The crystal structure of franckeite, Pb21.7Sn9.3Fe4.0Sb8.1S56.9

    DEFF Research Database (Denmark)

    Makovicky, Emil; Petricek, Vaclav; Dusek, Michal

    2011-01-01

    The layer-like crystal structure of franckeite from the mine of San José, Bolivia, exhibits a pronounced one-dimensional transversal wave-like modulation and a non-commensurate layer match in two dimensions. It consists of alternating pseudohexagonal (H) layers and pseudotetragonal (Q) slabs...... was refined as Pb0.74(Sn,Sb)0.26, whereas that of cations, which are adjacent to the interspace with lone electron pairs, with a configuration analogous to that observed in orthorhombic SnS, corresponds to (Sn,Sb)0.73Pb0.27. Iron is dispersed over the octahedral Sn4+ sites in the H layer. Transversal...

  5. The Impact of Education On Fertility and Child Mortality: Do Fathers Really Matter Less than Mothers? OECD Development Centre Working Paper, No. 217 (Formerly Webdoc No. 5)

    Science.gov (United States)

    Breierova, Lucia; Duflo, Esther

    2003-01-01

    This paper takes advantage of a massive school construction program that took place in Indonesia between 1973 and 1978 to estimate the effect of education on fertility and child mortality. Time and region varying exposure to the school construction program generates instrumental variables for the average education in the household, and the…

  6. Compassion and Caring in Nursing Claire Chambers Compassion and Caring in Nursing and Ryder Elaine Radcliffe £29.99 | 217pp 9781846192876 1846192870 [Formula: see text].

    Science.gov (United States)

    2009-09-23

    THE FOCUS of this book is empathy and sensitivity, dignity and respect, listening and responding, diversity and cultural competence, choice and priorities, and empowerment and advocacy. It is engaging and the references are contemporary. The case-study approach embeds the themes in practice. However, I sensed a feeling of professional despair in one study as the emotion evoked was palpable. The 'thoughts for your practice' section enables readers to reflect critically on their practice.

  7. 26 CFR 1.217-1 - Deduction for moving expenses paid or incurred in taxable years beginning before January 1, 1970.

    Science.gov (United States)

    2010-04-01

    ... or after a substantial period of unemployment or part-time employment, (ii) the beginning of work by... first time (for example, recent high school or college graduates), or individuals who are re-entering the labor force after a substantial period of unemployment or part-time employment. (i) In the case of...

  8. SU-E-T-217: Comprehensive Dosimetric Evaluation On 3D-CRT, IMRT and Non-Coplanar Arc Treatment for Prone Accelerated Partial Breast Irradiation (APBI)

    Energy Technology Data Exchange (ETDEWEB)

    Chiu, T; Yan, Y; Ramirez, E; Lee, P; Jiang, S; Gu, X [UT Southwestern Medical Center, Dallas, TX (United States)

    2015-06-15

    Purpose: Accelerated partial breast irradiation (APBI) is an effective treatment for early stage breast-cancer. Irradiation in a prone position can mitigate breast motion and spare heart and lung. In this study, a comprehensive study is performed to evaluate various treatment techniques for prone APBI treatment including: 3D-CRT, IMRT, co-planar and non-coplanar partial arcs treatment. Methods: In this treatment planning study, a left breast patient treated in prone position in our clinic was imported into Varian Eclipse TPS. Six beams tangential to chest wall were used in both 3D-CRT and IMRT plans. These six beams were coplanar in a transactional plane achieved by both gantry and couch rotation. A 60-beam IMRT plan was also created to explore the maximum benefit of co-planar IMRT. Within deliverable couch rotation range (±30°), partial arc treatment plans with one and up to ten couch positions were generated for comparison. For each plan, 30Gy in 6 fractions was prescribed to 95% PTV volume. Critical dosimetric parameters, such as conformity index, mean, maximum, and volume dose of organ at risk, are evaluated. Results: The conformity indexes (CI) are 3.53, 3.17, 2.21 and 1.08 respectively to 3D-CRT, 6-beam IMRT, 60-beam IMRT, and two-partial-arcs coplanar plans. However, arc plans increase heart dose. CI for non-coplanar arc plans decreases from 1.19 to 1.10 when increases couch positions. Maximum dose in ipsilateral lung (1.98 to 1.13 Gy), and heart (0.62 to 0.43 Gy) are steadily decreased with the increased number of non-coplanar arcs. Conclusions: The dosimetric evaluation results show that partial arc plans have improved CIs compared to conventional 3D-CRT and IMRT plans. Increasing number of partial arcs decreases lung and heart dose. The dosimetric benefit obtained from non-coplanar arcs should be considered with treatment delivery time.

  9. SU-E-J-217: Multiparametric MR Imaging of Cranial Tumors On a Dedicated 1.0T MR Simulator Prior to Stereotactic Radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Wen, N; Glide-Hurst, C; Liu, M; Hearshen, D; Brown, S; Siddiqui, S; Chetty, I [Henry Ford Health System, Detroit, MI (United States)

    2015-06-15

    Purpose: Quantitative magnetic resonance imaging (MRI) of cranial lesions prior to stereotactic radiosurgery (SRS) may improve treatment planning and provide potential prognostic value. The practicality and logistics of acquiring advanced multiparametric MRI sequences to measure vascular and cellular properties of cerebral tumors are explored on a 1.0 Tesla MR Simulator. Methods: MR simulation was performed immediately following routine CT simulation on a 1T MR Simulator. MR sequences used were in the order they were performed: T2-Weighted Turbo Spin Echo (T2W-TSE), T2 FLAIR, Diffusion-weighted (DWI, b = 0, 800 to generate an apparent diffusion coefficient (ADC) map), 3D T1-Weighted Fast Field Echo (T1W-FFE), Dynamic Contrast Enhanced (DCE) and Post Gadolinium Contrast Enhanced 3D T1W-FFE images. T1 pre-contrast values was generated by acquiring six different flip angles. The arterial input function was derived from arterial pixels in the perfusion images selected manually. The extended Tofts model was used to generate the permeability maps. Routine MRI scans took about 30 minutes to complete; the additional scans added 12 minutes. Results: To date, seven patients with cerebral tumors have been imaged and tumor physiology characterized. For example, on a glioblastoma patient, the volume contoured on T1 Gd images, ADC map and the pharmacokinetic map (Ktrans) were 1.9, 1.4, and 1.5 cc respectively with strong spatial correlation. The mean ADC value of the entire volume was 1141 μm2/s while the value in the white matter was 811 μm2/s. The mean value of Ktrans was 0.02 min-1 in the tumor volume and 0.00 in the normal white matter. Conclusion: Our initial results suggest that multiparametric MRI sequences may provide a more quantitative evaluation of vascular and tumor properties. Implementing functional imaging during MR-SIM may be particularly beneficial in assessing tumor extent, differentiating radiation necrosis from tumor recurrence, and establishing reliable bio-markers for treatment response evaluation. The Department of Radiation Oncology at Henry Ford Health System has research agreement with Varian Medical System and Philips Health Care.

  10. O papel subestimado do interlocutor na abordagem cognitiva da metáfora DOI - 10.5752/P.2358-3428.2014v18n34p217

    Directory of Open Access Journals (Sweden)

    Ulrike Schröder

    2014-07-01

    Full Text Available Uma das maiores críticas voltadas para a Teoria da Metáfora Conceitual é que Lakoff e Johnson (2003, 1999 partem de uma constelação idealizada de interlocutores, de modo que o processo da compreensão de uma metáfora simplesmente se dá por meio da ativação de metáforas conceptuais, entrincheiradas no cérebro dos participantes (GIBBS, 2007. Procurar-se-á investigar quais as abordagens que dirigem sua atenção ao ouvinte como parte ativa por coconstruir o significado particular da expressão metafórica em dependência do contexto pragmático, social e cultural em que os interlocutores estão inseridos. A questão central é até que ponto os estudos existentes conseguem reintegrar o processo holístico da comunicação, e, para tal, distinguimos entre três linhas de pesquisa a serem aprofundadas: estudos psicolinguísticos, textual-discursivos e pragmático-interacionais.Palavras-chave: Teoria da Metáfora Conceitual. Interlocutor. Compreensão. Comunicação. Interação.

  11. Melhaoui Mohammed, Peste, contagion et martyre. Histoire du fléau en Occident médiéval, Paris, Publisud, 2005, 217 p.

    Directory of Open Access Journals (Sweden)

    Stéphane Barry

    2007-07-01

    Full Text Available En France, à l’exception des études du médecin, historien et démographe Jean-Noël Biraben (1975-1976, peu de travaux existent sur la Peste noire et ses conséquences dans l’Occident musulman médiéval. On comprendra alors tout l’intérêt de l’ouvrage de Mohammed Melhaoui sur ce thème qu’il connaît bien puisqu’il lui a consacré non seulement une thèse de doctorat d’histoire, mais aussi quelques études portant notamment sur la « perception de la peste en pays chrétiens byzantins et musulman » (Co...

  12. PS2-17: Diabetes Social Support Feasibility Pilot Study: Utilizing Mobile Technology and Self-Identified Supporters to Enhance Self-Monitoring of Blood Glucose

    Science.gov (United States)

    Robinson, Brandi; Roblin, Douglas; Hipkens, James; Vupputuri, Suma; McMahon, Kevin

    2010-01-01

    Background and Aims: Self-monitoring of blood glucose (SMBG) is associated with improved glycemic control among patients with type 2 diabetes, however, the practice of daily self-monitoring is not optimal. Telecommunications technology may improve adherence to recommended self-management practices by remotely transmitting automated reminders to motivate patients, and utilizing social networking for peer support. The purpose of this pilot study is to demonstrate the feasibility and usability of mobile technology and the potential added value of social support to improve SMBG frequency and glycemic control among adults with type 2 diabetes. Methods: Adults 25–74 years of age with type 2 DM and an average HbA1c > 8.0% were recruited from Kaiser Permanente Georgia (KPGA) and Oakhurst Medical Center (OMC, a community health clinic) to participate in a 3-month study using wireless technology. Enrollment sessions with presentations on SMBG techniques, use of the wireless technology, and motivational coaching to enhance social support were conducted in November 2009. During the subsequent 3-months, both diabetes patients and their self-selected supporters will receive text messages to their cell phones summarizing a patient’s SMBG frequency and levels. Participants and their supporters will attend a disenrollment session in February 2010 when feasibility and usability will be assessed in focus groups. Results: 6 of 161 eligible diabetes patients at KPGA and 9 of 28 eligible diabetes patients at OMC, and their self-selected supporters, consented to participate. The average age of diabetes patients was 49.3 years. 86.7% (N=13) were African-American; and 33.3% (N=5) were male. Five days after enrollment, 60% (N=9) of patients had connected their wireless transmitters and had current blood glucose data. Follow-up phone calls will be made to ensure that all participants are connected to the wireless technology within 10 days of the enrollment session. Conclusion: Integrating mobile telecommunications technology with chronic disease management may empower patients in their own self-care and ease the burden on health care providers. Our study will evaluate the potential for studying the use of wireless mobile technology in a larger randomized controlled trial and will obtain participant comments on what changes might improve participant compliance.

  13. WE-G-217BCD-11: A New Phantom to Study Combined Effects of In-Plane (x,y) and Z Axis Resolution for 3-D Imaging.

    Science.gov (United States)

    Goodenough, D; Levy, J; Kristinsson, S; Fredriksson, J; Olafsdottir, H; Healy, A

    2012-06-01

    The aim of this work is to develop phantoms that can be used to sample the radial and 3D properties of a CT image, including in-plane (x,y) and z-axis information. The Phantom is amenable to mathematical analysis of the x, y, and z axis resolution properties separately and combined. A periodic pattern of a pair of opposed (30°) angled ramps is configured to produce a waveform profile across the CT image. A perfect CT image (with no loss of resolution) of the test object would produce a consistent geometric pattern of the intersection of a line with the pair of angled ramps. However, due to the finite resolution (x, y and z), the CT waveform profile will not yield the perfect profile; rather it will be influenced by slice thickness, and in-plane resolution (PSF, MTF), as well as noise limitations, and other sources of non-uniformity such as beam hardening etc. Various characteristics of the waveform profile including, amplitude, frequency, and slope (rate of climb) of the peaks, can be studied using mathematical analysis such as the Fourier transform. It will be shown how these performance characteristics are encoded in the wave pattern. The waveform profiles are visually examined and mathematically analyzed, to demonstrate the effect of Slice Thickness (z axis) and changes of In-Plane (x,y) Resolution and non-uniformity across the image field; moreover, the harmonic analysis of the waveform is used to predict, either the in-plane resolution (MTF), or the z-axis MTF when one of the two is already known. The Wave pattern phantom offers a way to consider 3-D imaging characteristics of a CT scanner by scanning a single repetitive test object that encodes both in-plane resolution and z-axis resolution and also offers a way to study non-uniformity effects throughout the CT plane (volume). DJG is a consultant to The Phantom Laboratory and Image OWL, Salem, NY. Funding of other authors is supplied by Image OWL Salem, NY. © 2012 American Association of Physicists in Medicine.

  14. Hyperspectral surface materials map of quadrangle 3770, Faizabad (217) and Parkhaw (218) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Science.gov (United States)

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Giles, Stuart A.; Johnson, Michaela R.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  15. Hyperspectral surface materials map of quadrangle 3770, Faizabad (217) and Parkhaw (218) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    Science.gov (United States)

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Giles, Stuart A.; Johnson, Michaela R.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  16. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 217, Revision 1 (FGE.217Rev1). Consideration of genotoxic potential for α,β-Unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: Lactones

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Lund, Pia

    the Procedure. Additional data on genotoxicity for the three representative substances, 5-ethyl-3-hydroxy-4-methylfuran-2(5H)-one [FL-no: 10.023], 3,4-dimethyl-5-pentylidenefuran-2(5H)-one [FL-no: 10.042] and furan-2(5H)-one [FL-no: 10.066], have now been provided. Based on the new data, the Panel concluded...... that 5-ethyl-3-hydroxy-4-methylfuran-2(5H)-one [FL-no: 10.023] does not give rise to concern with respect to genotoxicity and can accordingly, together with the structurally related substance, 3-hydroxy-4,5-dimethylfuran-2(5H)-one [FL-no: 10.030] for which it is a representative, be evaluated using...... the Procedure. For 3,4-dimethyl-5-pentylidenefuran-2(5H)-one [FL-no: 10.042] and furan-2(5H)-one [FL-no: 10.066] the concern for genotoxicity could not be ruled out and a combined micronucleus and Comet assay is requested for these two substances, covering the remaining seven substances [FL-no: 10.034, 10...

  17. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Science.gov (United States)

    2010-01-01

    ... Category 1(TBq) Category 1(Ci) Category 2(TBq) Category 2(Ci) Actinium-227 20 540 0.2 5.4 Americium-241 60... 2 54 Strontium-90 1,000 27,000 10 270 Thorium-228 20 540 0.2 5.4 Thorium-229 20 540 0.2 5.4...

  18. I. The metabolic properties of plutonium and allied materials

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  19. Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.

    Science.gov (United States)

    Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R; Wai, Chien M

    1999-09-01

    A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

  20. WITHDRAWN: Corrigendum to "World Association for the Advancement of Veterinary Parasitology (WAAVP): The 50th anniversary in 2013-History, achievements, and future perspectives" [Vet. Parasitol. 195 (2013) 206-217].

    Science.gov (United States)

    Eckert, J

    2014-01-15

    The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.vetpar.2013.12.026. The duplicate article has therefore been withdrawn.

  1. 217 YAP Is Ready to Rac and Rho: Elucidation of a Novel YAP-Driven Network That Potentiates Brain Cancer Cell Dispersal and Confers Poor Survival in Patients.

    Science.gov (United States)

    Shah, Sagar R; Tippens, Nathaniel; Park, JinSeok; Mohyeldin, Ahmed; Vela, Guillermo; Martinez-Gutierrez, Juan Carlos; Margolis, Seth S; Schmidt, Susanne; Levchenko, Andre; Quinones-Hinojosa, Alfredo

    2016-08-01

    Molecular pathways linking cell polarization and migration to extracellular cues regulate many pathological processes, including progression of aggressive and infiltrative cancers. Glioblastoma (GBM), the most common and lethal form of primary brain cancer, is characterized by its pronounced ability to disseminate into the intricate microenvironment of the human brain, confounding surgical excision and radiotherapy, leading to a median patient survival of 14 months. Progression results from defects in molecular pathways linking cell migration and invasion into surrounding tissue. However, the molecular engines are not known. Using patient-derived GBM tissues and cells, we profiled the expression of network moieties via Western blotting, quantitative real-time polymerase chain reaction and performed live cell time-lapse microscopy, bioinformatics analyses, in vivo intracranial GBM experiments using genetic and pharmacological inhibitors to delineate a prodispersal mechanism for management and treatment of GBMs. Yes-associated protein (YAP), a transcriptional coactivator, is overexpressed and hyperactive in 78% of GBMs and 50% of metastatic tumors to the brain (P < .05). Our studies demonstrate that YAP activates a Rho-GTPase switch to potentiate migratory speed by interacting with canonical pathways through direct transcriptional control. In addition, YAP mediates a proinvasive genetic network by direct posttranslational regulation. By coupling the regulation of migration and invasion, YAP drives tumor cell dispersal in vitro and in vivo (P < .05). Hyperactivation of this YAP-driven network in GBM confers poor patient outcome in clinical biopsies and The Cancer Genome Atlas (P < .05), suggesting a new signature in clinical prognosis of this aggressive and infiltrative cancer. Targeting this network using a proprietary pharmacological inhibitor attenuates tumor dispersal and growth (P < .05). YAP can critically control cellular locomotion through direct interaction with canonical molecular pathways controlling invasion and migration. Understanding the molecular underpinnings of this network is vital to the development of imperative prognostic and treatment approaches for cancer such as the new proprietary pharmacological inhibitor presented in this study.

  2. Methane origin in the Samail ophiolite: Comment on "Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    Science.gov (United States)

    Etiope, Giuseppe

    2017-01-01

    Miller et al. (2016) report a new study of fluids in the peridotites of the Samail ophiolite in Oman related to modern serpentinization (olivine hydration), a process that can provide energy and raw materials for chemosynthetic microbial life. The authors, in particular, report an isotopic composition for methane (CH4) in groundwater near Ibra (up to 1.4 mM) that is unusually 13C-enriched (δ13CCH4 ∼ +2.4 and +3‰ VPDB), and consider the gas origin to be uncertain, i.e., abiotic or microbial, and to be modulated by significant fractionation due to oxidation or diffusion. The purpose of this comment is to clarify and correct a few points concerning the possible origin of the δ13CCH4 values, with the intention to promote a fruitful and constructive debate, considering the interest that there is for serpentinization and the associated formation of various gases.

  3. Reply to "Methane origin in the Samail ophiolite: Comment on 'Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability'" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    Science.gov (United States)

    Miller, Hannah M.; Matter, Jürg M.; Kelemen, Peter; Ellison, Eric T.; Conrad, Mark; Fierer, Noah; Ruchala, Tyler; Tominaga, Masako; Templeton, Alexis S.

    2017-01-01

    We thank Dr. Giuseppe Etiope for his comment and the opportunity to further discuss why we consider the origin of the methane detected in subsurface fluids obtained from a peridotite aquifer in Oman to be enigmatic.

  4. Thermosalinograph data of the Hawaii Ocean Time-series (HOT) program in the North Pacific, 100 Miles North of Oahu, Hawaii for cruises HOT208-217 during 2009 (NCEI Accession 0069501)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  5. Niskin bottle data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 miles north of Oahu, Hawaii for cruises HOT208-217 during 2009 (NCEI Accession 0069177)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  6. CTD data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 miles north of Oahu, Hawaii for cruises HOT208-217 during 2009 (NCEI Accession 0068957)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  7. SU-D-217A-06: Impact of Anterior-Posterior (AP) and Posterior-Anterior (PA) Scout Scans on the CT Radiation Dose in the Whole Body PET/CT Scan.

    Science.gov (United States)

    Luo, D; Pan, T

    2012-06-01

    CT can contribute over 50% of radiation dose in the whole body (WB) PET/CT scan. Tube current modulation (TCM) is a standard technique for reducing CT radiation dose to the patient by changing the tube current with the patient size, and is controlled by a very low-dose scoutscan, which assumes the patient is positioned at the center of the CT gantry opening. However, most patients are not positioned at the center due to practicality or to avoid claustrophobic or to reduce time of radiation exposure from the patient to the technologist. We study the impact of the AP and PA scout scans to the patient radiation exposure from CT. Ina retrospective study of 200 patients, each received two WB PET/CT scans: one with AP, and the other one with PA. The helical CT with TCM and PET acquisitions were identical in both scans. Separation of the two scans was about 10 months in average. The scans were performed on four GE PET/CT scanners: three 16- and one 64-slice with the same TCM settings. The 200patients were selected for the same scan coverage and similar body weight (difference = 3 kg). The tube current in each slice and average exposure tothe patient were recorded and compared. The AP scout caused lower radiation dose on 94% of the patients. Both the tube current, and radiation exposure were reduced by 46±30 mA and 1.6±1.0 mGy, respectively. The effective radiation dose is reduced by 1.7±1.2 mSv. These results were statistically significant (p<0.00001). The AP scout caused significantly less radiation dose than the PA scout in the CT scan of the whole-body PET/CT scan. Care should be taken to select theorientation of the scout scan to achieve appropriate radiation exposure to the patient when TCM is applied. © 2012 American Association of Physicists in Medicine.

  8. Public Health and Primary Care - Partners in Population Health Griffiths Siân Gillam Stephen Hill Alison Public Health and Primary Care - Partners in Population Health 217 Oxford University Press 9780198508533 0198508530.

    Science.gov (United States)

    2007-10-24

    An interesting book, it seeks to help the reader to understand the complexity of health improvement, health care and health protection - and provides a practical public health toolkit. The first chapter, 'What is public health?', provides an excellent introduction to the subject, with a brief history lesson and connections to recent white papers and relevant government reports.

  9. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines

    Science.gov (United States)

    2012-01-01

    in- tractable pain in advanced rheumatoid arthritis ,” Clinical & Experimental Obstetrics & Gynecology, vol. 29, no. 3, pp. 197– 206, 2002. [118] B. C...Katz, “Neuropathic pain in patients with upper-extremity nerve injury,” Physiotherapy Canada, vol. 62, no. 3, pp. 190–201, 2010. Pain Research and

  10. Bénichou-Safar H., Le tophet de Salammbô à Carthage. Essai de reconstitution, Rome, 2004 (Collection de l’École française de Rome ; 342, 217 p.

    Directory of Open Access Journals (Sweden)

    Imed Ben Jerbania

    2006-10-01

    Full Text Available Le tophet de Salammbô à Carthage n’a pas cessé, depuis sa découverte en 1921, de faire l’objet d’une controverse dont on perçoit le reflet dans les différents travaux qui lui ont été consacrés. Il demeure dans ce sens un espace particulièrement intéressant pour l’étude de la mentalité religieuse des Carthaginois. Lieu sacré bénéficiant d’une longévité depuis l’époque archaïque jusqu’à la chute de la métropole punique, ce site présente un échantillonnage remarquablement ample de mobilier, d’in...

  11. Mouton Jean-Michel, Le Sinaï médiéval. Un espace stratégique de l’islam, Paris, PUF, 2000, 217 p.

    Directory of Open Access Journals (Sweden)

    Thierry Bianquis

    2011-12-01

    Full Text Available De petit format, agréablement présenté sur un papier de qualité et agrémenté de cartes claires, d’une typographie lisible tout en respectant les règles de transcription scientifique, cet ouvrage est plaisant à manier. La langue précise et légère, les idées s’enchaînant logiquement, le lecteur ne ressent aucun ennui à découvrir la topographie de cette péninsule désertique et à en suivre son histoire entre la conquête arabe en 639 et la conquête ottomane en 1516. En effet, Jean-Michel Mouton, ...

  12. Substituição parcial do milho e farelo de soja por sorgo e farelo de caroço de algodão extrusado em rações de frangos de corte - DOI: 10.4025/actascianimsci.v29i2.217 Partial substitution of the corn and soybean for sorghum and expander cottonseed meal in broilers’ rations - DOI: 10.4025/actascianimsci.v29i2.217

    Directory of Open Access Journals (Sweden)

    Jorge Vitor Ludke

    2007-11-01

    Full Text Available O experimento teve como objetivo avaliar a utilização do sorgo (50% e do farelo de caroço de algodão extrusado (0; 13,33; 26,66 e 39,99% em substituição ao milho e à proteína do farelo de soja em rações de frangos de corte. Foi conduzido um experimento utilizando 300 pintos de corte, machos, distribuídos em um delineamento inteiramente casualizado com cinco tratamentos e cinco repetições de 12 aves por parcela. As variáveis analisadas foram consumo de ração (CR, ganho de peso (GP, conversão alimentar (CA e características de carcaça. Para CR e GP, não houve diferenças estatísticas (p > 0,05 entre o tratamento controle e o segundo tratamento com exceção para CA no período de 22 a 42 dias. Com o resultado para GP houve diferenças significativas (p 0,05 para todos os parâmetros avaliados. Tanto o sorgo quanto o farelo de caroço de algodão extrusado em substituição ao milho e o farelo de soja é possível até 13,31%, melhorando a conversão alimentar.Partial substitution of the corn and soybean for sorghum and expander cottonseed meal in broilers’ rations. The experiment aimed to evaluate the use of sorghum (50% and the expander cottonseed meal (0; 13.33; 26.66; 39.99% in substitution to the corn and the protein of the soybean meal in broilers’ rations. An experiment was carried out using 300 male broiler chicks, distributed in a randomized arrangement with five treatments and five repetitions of 12 birds per parcel. The analyzed variables were ration consumption (RC, weight gain (WG, feed conversion (FC and characteristics of carcass. RC and WG did not present any statistical differences (p > 0.05 between the controlled treatment and the second treatment, except for FC during the period of 22 to 42 days. As for WG, significant statistical differences were found (p 0.05 for all the evaluated parameters. Both sorghum and the expander cottonseed meal in substitution to the corn and the soybean meal are possible, up to 13.31%, to improve the feed conversion.

  13. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  14. Behaviour of uranium series radionuclides in surface water (Crouzille, Limousin). Geochemical implications; Comportement des radionucleides des familles de l'uranium dans les eaux superficielles du site de la Crouzille (Limousin): implications geochimiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-06-15

    Understanding natural radionuclides behaviour in surface water is a required step to achieve uranium mine rehabilitation and preserve water quality. The first objective of this thesis is to determine which are the radionuclides sources in a drinking water reservoir. The second objective is to improve the knowledge about the behaviour of uranium series radionuclides, especially actinium. The investigated site is a brook (Sagnes, Limousin, France) which floods a peat bog contaminated by a former uranium mine and which empties into the Crouzille lake. It allows studying radionuclides transport in surface water and radionuclides retention through organic substance or water reservoir. Radionuclides distribution in particulate, colloidal and dissolved phases is determined thanks to ultra-filtrations. Gamma spectrometry allows measuring almost all natural radionuclides with only two counting stages. However, low activities of {sup 235}U series radionuclides impose the use of very low background well-type Ge detectors, such as those of the Underground Laboratory of Modane (France). Firstly, this study shows that no or few radionuclides are released by the Sagnes peat bog, although its radioactivity is important. Secondly, it provides details on the behaviour of uranium series radionuclides in surface water. More specifically, it provides the first indications of actinium solubility in surface water. Actinium's behaviour is very close to uranium's even if it is a little less soluble. (author)

  15. NCBI nr-aa BLAST: CBRC-ACAR-01-0852 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0852 ref|ZP_01035335.1| hypothetical protein ROS217_14576 [Roseovarius... sp. 217] gb|EAQ26410.1| hypothetical protein ROS217_14576 [Roseovarius sp. 217] ZP_01035335.1 0.003 28% ...

  16. NCBI nr-aa BLAST: CBRC-PABE-26-1117 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PABE-26-1117 ref|ZP_01033920.1| hypothetical protein ROS217_18782 [Roseovarius... sp. 217] gb|EAQ26601.1| hypothetical protein ROS217_18782 [Roseovarius sp. 217] ZP_01033920.1 2.5 28% ...

  17. NCBI nr-aa BLAST: CBRC-MDOM-11-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-11-0019 ref|ZP_01036200.1| hypothetical protein ROS217_04295 [Roseovarius... sp. 217] gb|EAQ25283.1| hypothetical protein ROS217_04295 [Roseovarius sp. 217] ZP_01036200.1 3.2 28% ...

  18. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    P. Bernot

    2005-07-13

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with {sup 231}Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or

  19. Transition wavelengths and unresolved transition array statistics of ions with Z = 72-89

    Energy Technology Data Exchange (ETDEWEB)

    Kilbane, D, E-mail: Deirdre.Kilbane@ucd.ie [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland)

    2011-08-28

    Potential extreme ultraviolet and soft x-ray radiation sources have been identified, using the flexible atomic code (FAC), as emission peaks arising from the 4d-4f and 4p-4d transitions in Pd-like to Rb-like ions of hafnium through actinium. The effects of configuration interaction are investigated and for increasing nuclear charge, these strong emitters are seen to separate and move to shorter wavelengths. Each source is characterized using the unresolved transition array model. They are proposed to complement the currently used nitrogen and argon sources in the 'water window', and as possible successors to tin in next-generation lithography.

  20. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  1. Analysis of the Yrast Bands with q-Deformed Moment of Inertia

    Institute of Scientific and Technical Information of China (English)

    FANG Xiang-Zheng; RUAN Tu-Nan

    2001-01-01

    The rigid-rotor with a q-deformed moment of inertia is introduced to describe the nuclear rotational spectra. With the representations of quantum algebra, the normal deformed and superdeformed bands are naturally differentiated by softness. The yrast normal deformed bands in rare earth and actinium regions, as well as the yrast superdeformed bands in A-190 and 150 regions are investigated. The calculated results agree with experimental data qualitatively well, and the values of the parameters are physically reasonable. This indicates that the fixed deformation, the stretching effect and the many body statistics effect are three possible dominant factors to govern nuclear rotational bands.

  2. NCBI nr-aa BLAST: CBRC-AGAM-07-0041 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available tive (ubiA-2) [Flavobacterium sp. MED217] gb|EAQ50082.1| 4-hydroxybenzoate octaprenyltransferase , putative (ubiA-2) [Leeuwenhoekiella blandensis MED217] ZP_01060587.1 2e-31 33% ...

  3. Gclust Server: 161377 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 161377 DME_CG18543_24660919 Cluster Sequences - 217 mtrm: matrimony CG18543-PA 1 1....er sequences Cluster Sequences Link to related sequences - Sequence length 217 Representative annotation mtrm: matrimony

  4. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics.

    Science.gov (United States)

    Singh-Joy, Subhashni D; McLain, Valerie C

    2008-01-01

    Poloxamers are polyoxyethlyene, polyoxypropylene block polymers. The impurities of commercial grade Poloxamer 188, as an example, include low-molecular-weight substances (aldehydes and both formic and acetic acids), as well as 1,4-dioxane and residual ethylene oxide and propylene oxide. Most Poloxamers function in cosmetics as surfactants, emulsifying agents, cleansing agents, and/or solubilizing agents, and are used in 141 cosmetic products at concentrations from 0.005% to 20%. Poloxamers injected intravenously in animals are rapidly excreted in the urine, with some accumulation in lung, liver, brain, and kidney tissue. In humans, the plasma concentration of Poloxamer 188 (given intravenously) reached a maximum at 1 h, then reached a steady state. Poloxamers generally were ineffective in wound healing, but were effective in reducing postsurgical adhesions in several test systems. Poloxamers can cause hypercholesterolemia and hypertriglyceridemia in animals, but overall, they are relatively nontoxic to animals, with LD(50) values reported from 5 to 34.6 g/kg. Short-term intravenous doses up to 4 g/kg of Poloxamer 108 produced no change in body weights, but did result in diffuse hepatocellular vacuolization, renal tubular dilation in kidneys, and dose-dependent vacuolization of epithelial cells in the proximal convoluted tubules. A short-term inhalation toxicity study of Poloxamer 101 at 97 mg/m(3) identified slight alveolitis after 2 weeks of exposure, which subsided in the 2-week postexposure observation period. A short-term dermal toxicity study of Poloxamer 184 in rabbits at doses up to 1000 mg/kg produced slight erythema and slight intradermal inflammatory response on histological examination, but no dose-dependent body weight, hematology, blood chemistry, or organ weight changes. A 6-month feeding study in rats and dogs of Poloxamer 188 at exposures up to 5% in the diet produced no adverse effects. Likewise, Poloxamer 331 (tested up to 0.5 g/kg day(-1)), Poloxamer 235 (tested up to 1.0 g/kg day(-1)), and Poloxamer 338 (at 0.2 or 1.0 g/kg day(-1)) produced no adverse effects in dogs. Poloxamer 338 (at 5.0 g/kg day(-1)) produced slight transient diarrhea in dogs. Poloxamer 188 at levels up to 7.5% in diet given to rats in a 2-year feeding study produced diarrhea at 5% and 7.5% levels, a small decrease in growth at the 7.5% level, but no change in survival. Doses up to 0.5 mg/kg day(-1) for 2 years using rats produced yellow discoloration of the serum, high serum alkaline phosphatase activity, and elevated serum glutamicpyruvic transaminase and glutamic-oxalacetic transaminase activities. Poloxamers are minimal ocular irritants, but are not dermal irritants or sensitizers in animals. Data on reproductive and developmental toxicity of Poloxamers were not found. An Ames test did not identify any mutagenic activity of Poloxamer 407, with or without metabolic activation. Several studies have suggested anticarcinogenic effects of Poloxamers. Poloxamers appear to increase the sensitivity to anticancer drugs of multidrug-resistant cancer cells. In clinical testing, Poloxamer 188 increased the hydration of feces when used in combination with a bulk laxative treatment. Compared to controls, one study of angioplasty patients receiving Poloxamer 188 found a reduced myocardial infarct size and a reduced incidence of reinfarction, with no evidence of toxicity, but two other studies found no effect. Poloxamer 188 given to patients suffering from sickle cell disease had decreased pain and decreased hospitilization, compared to controls. Clinical tests of dermal irritation and sensitization were uniformly negative. The Cosmetic Ingredient Review (CIR) Expert Panel stressed that the cosmetic industry should continue to use the necessary purification procedures to keep the levels below established limits for ethylene oxide, propylene oxide, and 1,4-dioxane. The Panel did note the absence of reproductive and developmental toxicity data, but, based on molecular weight and solubility, there should be little skin penetration and any penetration of the skin should be slow. Also, the available data demonstrate that Poloxamers that are introduced into the body via routes other than dermal exposure have a rapid clearance from the body, suggesting that there would be no risk of reproductive and/or developmental toxicity. Overall, the available data do not suggest any concern about carcinogenesis. Although there are gaps in knowledge about product use, the overall information available on the types of products in which these ingredients are used, and at what concentration, indicates a pattern of use. Based on these safety test data and the information that the manufacturing process can be controlled to limit unwanted impurities, the Panel concluded that these Poloxamers are safe as used.

  5. Les professions langagieres a l'aube de l'an 2000: Recherches pedagogiques et linguistiques en traduction, redaction et terminologie (The Language Professions at the Dawn of the Year 2000: Pedagogical and Linguistic Research in Translation, Editing and Terminology). Publication B-217.

    Science.gov (United States)

    Guevel, Zelie, Ed.; Clerc, Isabelle, Ed.

    Essays, all in French, address issues in language teacher and translator training. They include: "Les competences linguistiques et discursives du redacteur professionel: un ensemble a circonscrire" ("Linguistic and Discourse Competencies of the Professional Editor: A Unity To Define") (Celine Beaudet); "Les composantes d'un enseignement systemique…

  6. Purification of cerium, neodymium and gadolinium for low background experiments

    Directory of Open Access Journals (Sweden)

    Boiko R.S.

    2014-01-01

    Full Text Available Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search, 136Ce (2β+ candidate with one of the highest Q2β. The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  7. Large scale accelerator production of (225)Ac: Effective cross sections for 78-192MeV protons incident on (232)Th targets.

    Science.gov (United States)

    Griswold, J R; Medvedev, D G; Engle, J W; Copping, R; Fitzsimmons, J M; Radchenko, V; Cooley, J C; Fassbender, M E; Denton, D L; Murphy, K E; Owens, A C; Birnbaum, E R; John, K D; Nortier, F M; Stracener, D W; Heilbronn, L H; Mausner, L F; Mirzadeh, S

    2016-12-01

    Actinium-225 and (213)Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of (225)Ac. The high-energy proton spallation reaction on natural thorium metal targets has been utilized to produce millicurie quantities of (225)Ac. The results of sixteen irradiation experiments of thorium metal at beam energies between 78 and 192MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL). Excitation functions for actinium and thorium isotopes, as well as for some of the fission products, are presented. The cross sections for production of (225)Ac range from 3.6 to 16.7mb in the incident proton energy range of 78-192MeV. Based on these data, production of curie quantities of (225)Ac is possible by irradiating a 5.0gcm(-2 232)Th target for 10 days in either BNL or LANL proton irradiation facilities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Directory of Open Access Journals (Sweden)

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  9. DEVELOPMENT OF PHYSICAL CHEMISTRY (SELECTED ARTICLES),

    Science.gov (United States)

    Reviews are presented on the historical background of three areas of physical chemistry : Chemical kinetics (418 references); Thermochemistry (217 references); and Radiation chemistry (271 references).

  10. Dicty_cDB: Contig-U14370-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available n 73 Query: 74 ggtattgntgaaactgaattactatcncataatnaatccnatgaaaaagttttnnacnca 133 ||||||||||||||||||||||||||||...|||||||||||||||||||||||||||||||| Sbjct: 74 ggtattgntgaaactgaattactatcncataatnaatccnatgaaaaagttttnnacnca 133 ...||||| Sbjct: 217 tcaaatacaattaaaaaanaagntgntcnaaaaaatgtnagagtaatgatnatttccccn 158 Query: 74 ggtattgntgaaactgaattactatcncataatnaatccna...|||||||||||||||||||||||||||| Sbjct: 157 ggtattgntgaaactgaattactatcncataatnaatccnatgaaaaagttttnnacnca 98 Quer

  11. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  12. Temporal Variations in Surface Concentrations of Terrestrial Lead 210 and Uranium 235 Radionucleides

    Science.gov (United States)

    Yoshimori, M.

    We have started to measure the surface concentrations of terrestrial radionucleides of lead 210 and uranium 235 in Tokyo (N35, E139) in 2002. Lead 210 which is a daughter nucleus of Rn-222 (uranium series) emits 46 keV gamma-ray with a half-life of 22.4 years, while uranium 235 (actinium series) emits a gamma-ray at 186 keV with a half-life of 0.7 billion years. The present measurement of the surface concentration of lead 210 exhibits two peaks in spring and fall, similar to the beryllium 7 seasonal variations, while the uranium 235 concentration does not vary with time within statistical errors. These two terrestrial radionucleides exhibit different temporal variations on the surface. We discuss possible explanations for the differences in the temporal variations from a point of view of differences in their altitude distribution.

  13. Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion

    Science.gov (United States)

    Ferrer, R.; Barzakh, A.; Bastin, B.; Beerwerth, R.; Block, M.; Creemers, P.; Grawe, H.; de Groote, R.; Delahaye, P.; Fléchard, X.; Franchoo, S.; Fritzsche, S.; Gaffney, L. P.; Ghys, L.; Gins, W.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Loiselet, M.; Lutton, F.; Moore, I. D.; Martínez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Raeder, S.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Thomas, J-C; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2017-01-01

    Resonant laser ionization and spectroscopy are widely used techniques at radioactive ion beam facilities to produce pure beams of exotic nuclei and measure the shape, size, spin and electromagnetic multipole moments of these nuclei. However, in such measurements it is difficult to combine a high efficiency with a high spectral resolution. Here we demonstrate the on-line application of atomic laser ionization spectroscopy in a supersonic gas jet, a technique suited for high-precision studies of the ground- and isomeric-state properties of nuclei located at the extremes of stability. The technique is characterized in a measurement on actinium isotopes around the N=126 neutron shell closure. A significant improvement in the spectral resolution by more than one order of magnitude is achieved in these experiments without loss in efficiency. PMID:28224987

  14. Origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department); Origine des elements de la famille de l'uranium-235 observes dans la riviere Ellez a proximite du reacteur nucleaire experimental EL4 en cours de demantelement (Mont d'Arree - departement du Finistere). Resultats et premiers constats annee 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 ({sup 227}Ac), non born by its ascendents which are {sup 235}U and {sup 231}Pa is observed. This phenomenon is characterized by mass activities superior to these ones of {sup 235}U and able to reach these ones of {sup 238}U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil ({sup 210}Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  15. Evaluation of total effective dose due to certain environmentally placed naturally occurring radioactive materials using a procedural adaptation of RESRAD code.

    Science.gov (United States)

    Beauvais, Z S; Thompson, K H; Kearfott, K J

    2009-07-01

    Due to a recent upward trend in the price of uranium and subsequent increased interest in uranium mining, accurate modeling of baseline dose from environmental sources of radioactivity is of increasing interest. Residual radioactivity model and code (RESRAD) is a program used to model environmental movement and calculate the dose due to the inhalation, ingestion, and exposure to radioactive materials following a placement. This paper presents a novel use of RESRAD for the calculation of dose from non-enhanced, or ancient, naturally occurring radioactive material (NORM). In order to use RESRAD to calculate the total effective dose (TED) due to ancient NORM, a procedural adaptation was developed to negate the effects of time progressive distribution of radioactive materials. A dose due to United States' average concentrations of uranium, actinium, and thorium series radionuclides was then calculated. For adults exposed in a residential setting and assumed to eat significant amounts of food grown in NORM concentrated areas, the annual dose due to national average NORM concentrations was 0.935 mSv y(-1). A set of environmental dose factors were calculated for simple estimation of dose from uranium, thorium, and actinium series radionuclides for various age groups and exposure scenarios as a function of elemental uranium and thorium activity concentrations in groundwater and soil. The values of these factors for uranium were lowest for an adult exposed in an industrial setting: 0.00476 microSv kg Bq(-1) y(-1) for soil and 0.00596 microSv m(3) Bq(-1) y(-1) for water (assuming a 1:1 234U:238U activity ratio in water). The uranium factors were highest for infants exposed in a residential setting and assumed to ingest food grown onsite: 34.8 microSv kg Bq(-1) y(-1) in soil and 13.0 microSv m(3) Bq(-1) y(-1) in water.

  16. 两种稀土产品中放射性核素分析研究%ANALYSIS OF RADIONUCLIDES IN TWO RARE EARTH PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    周程; 孙恋君

    2009-01-01

    利用高纯锗γ谱仪对两个稀土产品氯化镧和氯化钇的样品进行能谱分析,研究经湿法冶炼工艺后的稀土产品中放射性核素的活度变化.结果表明,样品中存在天然放射性钍系和锕-铀系的核素,以及天然放射性核素~(138)La和~(176)Lu,但两个样品中所含的放射性核素不相同.氯化镧产品中锕-铀系和钍系核素放射性未达平衡,其主要子体~(224)Ra和~(227)Th的含量随时间发生明显变化,约60天达到平衡;而氯化钇产品没有这种现象.%This paper describes a study on raidoactivity change of rare-earth products after hydrometallurgy technology,using HPGe gamma spectrometer to analyze two rare earth products (LaCl_3 and YCl_3).The results show that in the two samples exist natural radionuclides of thorium series and actinium-uranium series as well as other natural radionuclides 138 La and 176 Lu.In the sample of lanthanum chloride the radioactivity of actinium-uranium series and thorium series has not reached balance,the contents of their main progenies ~(226)Ra and ~(227)Th obviously changes with the time,reaching balance 60 days later,while YCl_3 keeps stability.

  17. Genome Sequences of Three Highly Copper-Resistant Salmonella enterica subsp. I Serovar Typhimurium Strains Isolated from Pigs in Denmark

    DEFF Research Database (Denmark)

    Qin, Yanan; Hasman, Henrik; Aarestrup, Frank Møller

    2014-01-01

    Salmonella typhimurium is the causative agent of typhoid fever, which causes nearly 21.7 million illnesses and 217,000 deaths around the world each year. Here, we describe the draft genome sequences of the Salmonella typhimurium strains S7, S15, and S23, isolated from copper-fed pigs in Denmark...

  18. Planck 2015 results: VII. High Frequency Instrument data processing: Time-ordered information and beams

    DEFF Research Database (Denmark)

    Adam, R.; Ade, P. A R; Aghanim, N.

    2016-01-01

    The Planck High Frequency Instrument (HFI) has observed the full sky at six frequencies (100, 143, 217, 353, 545, and 857 GHz) in intensity and at four frequencies in linear polarization (100, 143, 217, and 353 GHz). In order to obtain sky maps, the time-ordered information (TOI) containing...

  19. NCBI nr-aa BLAST: CBRC-TTRU-01-0165 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0165 ref|XP_710009.1| CTA217 antisense protein [Candida albicans SC531...4] gb|EAK90732.1| CTA217 antisense protein [Candida albicans SC5314] XP_710009.1 2e-04 36% ...

  20. NCBI nr-aa BLAST: CBRC-SCER-04-0003 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SCER-04-0003 ref|ZP_01035567.1| TRAP dicarboxylate transporter, DctM subunit, putative [Roseo...varius sp. 217] gb|EAQ25732.1| TRAP dicarboxylate transporter, DctM subunit, putative [Roseovarius sp. 217] ZP_01035567.1 5.3 28% ...

  1. NCBI nr-aa BLAST: CBRC-SARA-01-0489 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0489 ref|ZP_01035526.1| exopolysaccharide biosynthesis domain protein [Roseo...varius sp. 217] gb|EAQ25691.1| exopolysaccharide biosynthesis domain protein [Roseovarius sp. 217] ZP_01035526.1 1.0 26% ...

  2. NCBI nr-aa BLAST: CBRC-DSIM-01-0068 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DSIM-01-0068 ref|ZP_01038050.1| Nitric oxide reductase large subunit, cytochrome b [Roseo...varius sp. 217] gb|EAQ23442.1| Nitric oxide reductase large subunit, cytochrome b [Roseovarius sp. 217] ZP_01038050.1 2.6 29% ...

  3. NCBI nr-aa BLAST: CBRC-SARA-01-0832 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0832 ref|ZP_01035526.1| exopolysaccharide biosynthesis domain protein [Roseo...varius sp. 217] gb|EAQ25691.1| exopolysaccharide biosynthesis domain protein [Roseovarius sp. 217] ZP_01035526.1 1.0 26% ...

  4. NCBI nr-aa BLAST: CBRC-TTRU-01-1191 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1191 ref|ZP_01059110.1| transporter, NRAMP family protein [Leeuwenhoek...iella blandensis MED217] gb|EAQ50942.1| transporter, NRAMP family protein [Leeuwenhoekiella blandensis MED217] ZP_01059110.1 0.81 28% ...

  5. AcEST: BP915836 [AcEST

    Lifescience Database Archive (English)

    Full Text Available udouridine synthase OS=Leeuwenhoekiell... 33 5.8 tr|A8L3M4|A8L3M4_FRASN Acyltransferase 3 OS=Frankia sp. (st...9FLAO Pseudouridine synthase OS=Leeuwenhoekiella blandensis MED217 GN=MED217_04192 PE=3 SV=1 Length = 265 Sc

  6. NCBI nr-aa BLAST: CBRC-TTRU-01-0751 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0751 ref|ZP_01059110.1| transporter, NRAMP family protein [Leeuwenhoek...iella blandensis MED217] gb|EAQ50942.1| transporter, NRAMP family protein [Leeuwenhoekiella blandensis MED217] ZP_01059110.1 0.086 28% ...

  7. NCBI nr-aa BLAST: CBRC-TTRU-01-1149 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1149 ref|ZP_01061727.1| putative transmembrane ion channel [Leeuwenhoe...kiella blandensis MED217] gb|EAQ48690.1| putative transmembrane ion channel [Leeuwenhoekiella blandensis MED217] ZP_01061727.1 0.025 32% ...

  8. NCBI nr-aa BLAST: CBRC-TTRU-01-0513 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0513 ref|ZP_01059110.1| transporter, NRAMP family protein [Leeuwenhoek...iella blandensis MED217] gb|EAQ50942.1| transporter, NRAMP family protein [Leeuwenhoekiella blandensis MED217] ZP_01059110.1 0.15 26% ...

  9. AcEST: BP915861 [AcEST

    Lifescience Database Archive (English)

    Full Text Available LAO Cell division protein ftsZ OS=Leeuwenhoek... 33 7.0 tr|B2VQY7|B2VQY7_PYRTR Predicted protein OS=Pyrenoph...NKTDS 168 >tr|A3XI85|A3XI85_9FLAO Cell division protein ftsZ OS=Leeuwenhoekiella blandensis MED217 GN=MED217

  10. NCBI nr-aa BLAST: CBRC-XTRO-01-0063 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0063 ref|YP_564181.1| major facilitator superfamily MFS_1 [Shewanella ...denitrificans OS217] gb|ABE56458.1| major facilitator superfamily MFS_1 [Shewanella denitrificans OS217] YP_564181.1 3e-54 44% ...

  11. NCBI nr-aa BLAST: CBRC-DMEL-02-0062 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DMEL-02-0062 ref|YP_563653.1| hypothetical protein Sden_2651 [Shewanella denit...rificans OS217] gb|ABE55930.1| hypothetical protein Sden_2651 [Shewanella denitrificans OS217] YP_563653.1 4.1 30% ...

  12. GETDB: 103857 [GETDB

    Lifescience Database Archive (English)

    Full Text Available (SG) ubiquitous epi, fb, gut no specific pattern - - comment1:A, comment2:17C5 - ...GFP no specific pattern Lethality - Also known as - Original Comments comment1:A, comment2:17C5 Disc (Image)

  13. 77 FR 23547 - Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to Columbia River Crossing...

    Science.gov (United States)

    2012-04-19

    ... Columbia River originates on the west slope of the Rocky Mountains in Canada and flows approximately 1,200... Part 217 Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to Columbia River... Administration 50 CFR Part 217 RIN 0648-BB16 Taking and Importing Marine Mammals; Taking Marine...

  14. Regulatory Assistance, Stakeholder Outreach, and Coastal and Marine Spatial Planning Activities in Support of Marine and Hydrokinetic Energy Deployment

    Energy Technology Data Exchange (ETDEWEB)

    Geerlofs, Simon H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Copping, Andrea E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Van Cleve, Frances B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Blake, Kara M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hanna, Luke A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2011-09-01

    This fiscal year 2011 progress report summarizes activities carried out under DOE Water Power Task 2.1.7, Permitting and Planning. Activities under Task 2.1.7 address the concerns of a wide range of stakeholders with an interest in the development of the marine and hydrokinetic (MHK) energy industry, including regulatory and resource management agencies, tribes, nongovernmental organizations, and industry.

  15. Human Factors Implications and Issues in Network Enabled Operations

    Science.gov (United States)

    2006-08-28

    organisationnelle de commandement et de contrôle existante. Sans doute plus important encore, du point de CR 2006-217...to fight and how they actually perform on the battlefield.28 If CR 2006-217 5...defects mentality, risk aversion, poorly designed war fighting experiments, and widespread contentment with current performance , expectations for NCW will

  16. Dicty_cDB: Contig-U15308-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ectin 6 mRNA, ... 217 2e-54 A35715( A35715 ;A28580;I52382;A61369;G01810;S54877;S65689) fodrin ... 217 2e-54 ...ens mRNA; cDNA DKFZp686H2... 113 3e-23 A47213( A47213 ) beta-fodrin - human (fragment) &S65762_1(S65762|...

  17. 48 CFR 3017.9000 - Clauses (USCG).

    Science.gov (United States)

    2010-10-01

    ... officer may, in whole or in part (such as after incidents), increase the dollar amounts in the clause at (HSAR) 48 CFR 3052.217-95(b)(6) and (c)(1) consistent with contract size, inflation, and other... dollar amounts in the clause at (HSAR) 48 CFR 3052.217-95(b)(6) and (c)(1) consistent with contract...

  18. EST Table: BP117858 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available iquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effete)...ilar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum] FS793905 ce-- ...

  19. Biochemical composition of zooplankton from the northern Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Bhat, K.L.; Sreepada, R.A.; Ansari, Z.A.

    stream_size 7 stream_content_type text/plain stream_name Pak_J_Mar_Sci_2_17.pdf.txt stream_source_info Pak_J_Mar_Sci_2_17.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  20. Gclust Server: 121213 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 121213 HSA_113426727 Cluster Sequences Related Sequences(20) 217 XP_001131030.1 PRE...DICTED: hypothetical protein ; no annotation 1 1.00e-99 0.0 0.0 0.0 0.0 0.0 12.5 Show 121213 Cluster ID 12121...equences(20) Sequence length 217 Representative annotation XP_001131030.1 PREDICT

  1. NCBI nr-aa BLAST: CBRC-AGAM-07-0045 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-07-0045 ref|ZP_01061096.1| copper/silver efflux P-type ATPase [Flavobacte...rium sp. MED217] gb|EAQ49147.1| copper/silver efflux P-type ATPase [Leeuwenhoekiella blandensis MED217] ZP_01061096.1 1e-128 60% ...

  2. AcEST: DK946077 [AcEST

    Lifescience Database Archive (English)

    Full Text Available in nutrient binding OS=Leeuwenhoekiella blandensis MED217 GN=MED217_07701 PE=4 SV...AFSVLTWVNPYMWQLSNQFKYFSLSLSLE 60 >tr|A3XME9|A3XME9_9FLAO Putative outer membrane protein, probably involved

  3. 75 FR 67719 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Science.gov (United States)

    2010-11-03

    .... Jackson, No. 10-cv-02859-PJH (N.D. Cal.). Plaintiff filed a deadline suit to compel the Administrator to... (ICAPCD) Rules 201, 202 and 217 submitted to the Environmental Protection Agency (EPA) on or about August... deadlines for EPA's action on ICAPCD Rules 201, 202 and 217. DATES: Written comments on the proposed...

  4. Gene : CBRC-TTRU-01-0165 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0165 Novel UN D UNKNOWN HMDH_SCHMA 0.007 29% ref|XP_710009.1| CTA217 antisense... protein [Candida albicans SC5314] gb|EAK90732.1| CTA217 antisense protein [Candida albicans SC5314

  5. Resonance Capture in Unbalanced Dual-Spin Spacecraft

    Science.gov (United States)

    1994-03-01

    York, 1989. 22. Wittenburg, Jens. "Beitrige zur dynamik von gyrostaten." In Convegno Inter- nazaionale sul Tema: Metodi Valutativi Nella Fisica ...Matematica, Roma, 15-19 dicembre 1972, Problemi Attuali di Scienza e di Cultura , Quaderno N. 217, pages 217-354. Accademia Nazionale dei Lincei, 1975. 23

  6. Benthic harpacticoid copepod community of Saphala salt marsh along the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Ingole, B.S.; Ansari, Z.A; Parulekar, A

    stream_size 4 stream_content_type text/plain stream_name Indian_J_Mar_Sci_19_217.pdf.txt stream_source_info Indian_J_Mar_Sci_19_217.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  7. 78 FR 43850 - Opportunity for Designation in Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ...

    Science.gov (United States)

    2013-07-22

    ... State Route 217; State Route 217 east to Prairie Dog Town Fork of the Red River; Prairie Dog Town Fork of the Red River southeast to the Briscoe County line; the northern Briscoe County line; the northern..., Lake of the Woods, Marshall, Beltrami, Polk, Pennington, Red Lake, and Clearwater Counties. In...

  8. 75 FR 36348 - Opportunity for Designation in the Amarillo, TX; Cairo, IL; and State of North Carolina Areas

    Science.gov (United States)

    2010-06-25

    ... Donley County; the southern Donley and Armstrong County lines west to Prairie Dog Town Fork of the Red River; Prairie Dog Town Fork of the Red River northwest to State Route 217; State Route 217 west to FM... Carolina) official agencies will end on September 30, 2010. In the March 31, 2010, Federal Register (71...

  9. Adjunctive levetiracetam in children, adolescents, and adults with primary generalized seizures: Open-label, noncomparative, multicenter, long-term follow-up study.

    LENUS (Irish Health Repository)

    Delanty, Norman

    2012-02-01

    Purpose: To evaluate the long-term efficacy and tolerability of adjunctive levetiracetam (LEV) in patients with uncontrolled idiopathic generalized epilepsy (IGE). Methods: This phase III, open-label, long-term, follow-up study (N167; NCT00150748) enrolled patients (4 to <65 years) with primary generalized seizures (tonic-clonic, myoclonic, absence). Patients received adjunctive LEV at individualized doses (1,000-4,000 mg\\/day; 20-80 mg\\/kg\\/day for children\\/adolescents weighing <50 kg). Efficacy results are reported for all seizure types [intention-to-treat (ITT) population, N = 217] and subpopulations with tonic-clonic (n = 152), myoclonic (n = 121), and\\/or absence (n = 70) seizures at baseline. Key Findings: One hundred twenty-five (57.6%) of 217 patients were still receiving treatment at the end of the study. Mean (standard deviation, SD) LEV dose was 2,917.5 (562.9) mg\\/day. Median (Q1-Q3) exposure to LEV was 2.1 (1.5-2.8) years, and the maximum duration was 4.6 years. Most patients were taking one (124\\/217, 57.1%) or >\\/=2 (92\\/217, 42.4%) concomitant antiepileptic drugs (AEDs). Seizure freedom of >\\/=6 months (all seizure types; primary efficacy end point) was achieved by 122 (56.2%) of 217 patients, and 49 (22.6%) of 217 patients had complete seizure freedom. Seizure freedom of >\\/=6 months from tonic-clonic, myoclonic, and absence seizures was achieved by 95 (62.5%) of 152, 75 (62.0%) of 121, and 44 (62.9%) of 70 patients, respectively. Mean (SD) maximum seizure freedom duration was 371.7 (352.4) days. At least one treatment-emergent adverse event (TEAE) was reported by 165 (76%) of 217 patients; most TEAEs were mild\\/moderate in severity, with no indication of an increased incidence over time. Seventeen (7.8%) of 217 patients discontinued medication because of TEAEs. The most common psychiatric TEAEs were depression (16\\/217, 7.4%), insomnia (9\\/217, 4.1%), nervousness (8\\/217, 3.7%), and anxiety (7\\/217, 3.2%). Significance: Adjunctive

  10. Ribozyme对癌基因ki-rasG12V mRNA的剪切及其特异性%Cleavage of Oncogene ki-rasG12V mRNA by Ribozyme and It' s Specificity

    Institute of Scientific and Technical Information of China (English)

    吴国祥; 方裕强; 许国铭; 李兆申; 陆德如

    2000-01-01

    目的:设计切割ki-rasG12vmRNA的特异性ribozyme(Rz217),明确其对癌基因ki-rasG12VmRNA的细胞内外切割活性,为以ki-rasG12VmRNA为特异性靶分子的基因治疗及癌基因ki-ras的功能研究提拱一种新的途径。方法:依Symons总结的"锤头结构"原理,设计一种能特异性切割ki-rasG12VmRNA的ribozyme,利用DNA重组技术构建ki-rasG12V外显子1和ri-bozyme Rz217的体外转录质粒及ribozyme Rz217的真核表达质粒,体外转录获得ribozyme Rz217及ki-rasG12V外显子1 mRNA,在含Mg2+溶液中ribozyme Rz217对其靶RNA分子进行切割。以RT-PCR对转染ribozyme Rz217真核表达质粒的细胞ki-rasG12VmRNA进行半定量分析。结果:ki-rasG12V外显子1体外转录mRNA分子,能被ribozyme Rz217定点切割而野生型ki-ras外显子1体外转录mRNA则不被切割;转染ribozyme Rz217的胰癌细胞ki-rasG12VmRNA含量减少,而转染ribozyme Re217的肝癌细胞其内源性ki-ras mRNA含量无明显变化。结论:ribozyme Rz217无论在细胞内外均能剪切突变型ki-ras mRNA(G12V)而且其切割作用为突变型ki-rasG12VmRNA特异性的。%Objective: To design and confirm the cleavage activity of ribozyme Rz217 to oncogene ki-rasG12V messenger RNA and search for a new method for gene therapy targeting oncogene ki-ras. Methods: According to Symon' s principle,design an ribozyme specific for ki-rasc12v mRNA, both the constructs for transcription in vitro of ribozyme Rz217 and ki-ras exonl and the mammalian expression constructs of ribozyme Rz217 were constructed by DNA recombinant technique,ribozyme Rz217 and ki-ras exonl mRNA was obtained by transcription in vitro with T7 and SP6 RNA polymerase. Pancre atic carcinoma cell line PaTu8988 and human hepatocellular carcinomacell line BEL7404 were transfected with Rz217 mammalian expression constructs and the level of endogenous ki-rasG12V mRNA or ki-ras mRNA was determined by semiquantitative RT-PCR. Results: Not only in vitro

  11. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  12. Teadlasena poliitikas - võimalused ja piirid = Als Wissenschaftler in der Politik - Chancen und Grenzen / Eiki Berg

    Index Scriptorium Estoniae

    Berg, Eiki, 1970-

    2005-01-01

    Autori hinnangul lasub teadlasel poliitikas suurem vastutus kui mistahes valdkonna esindajal, sest teaduslikult argumenteeritud poliitilised otsused on teadmiste jõu ja poliitilise võimu sümbioos. Vt. ka kommentaare lk. 217-222,467-472

  13. RJHS Vol 5(2) SOS.cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    ... deaths with 85% occurring in Sub-Saharan Africa and Southern Asia [1]. .... Cardiovascular Journal of Africa 24(4):217-222. Correspondence author: Thajasvarie Naicker. Optics and Imaging Centre, College of Health Sciences, University of ...

  14. BIOMASS, SPECIES IDENTIFICATION, TAXONOMIC CODE, SPECIES IDENTIFICATION - LIFE STAGE and species abundance tows data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-10 to 2004-10-07 (NODC Accession 0113896)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113896 includes tows and biological data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211, HX215, HX217,...

  15. 78 FR 31519 - Endangered Species; File No. 13543

    Science.gov (United States)

    2013-05-24

    ...Notice is hereby given that South Carolina Department of Natural Resources [Responsible Party: Robert Boyles], 217 Ft. Johnson Rd., Charleston, SC 29412, has been issued a modification to scientific research Permit No....

  16. Effects of Vitamin C on Kidney and Bone of Rats Exposed to Low ...

    African Journals Online (AJOL)

    304. ISSN 0794-5698. Effects of ... 2Department of Biochemistry, University of Benin, Benin City, Nigeria ..... Annals of Clinical Biochemistry, 36: 267-. 300. ... Environmental Research, 15: 206-217. ... lactation. International Journal of Morphology,.

  17. FastStats: Oral and Dental Health

    Science.gov (United States)

    ... What's this? Submit Button NCHS Home Oral and Dental Health Recommend on Facebook Tweet Share Compartir Data ... 2016, table 60 [PDF – 9.8 MB] Dental visits Percent of children aged 2-17 years ...

  18. Data of evolutionary structure change: 1GCVA-1YGDD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1GCVA-1YGDD 1GCV 1YGD A D -AFTACEKQTIGKIAQVLAKSPEAYGAECLARLFVTHPG...R MHLTPEEKSAVTALWGKV--NVDEVGGEALGRLLVVYPETQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSEL... 217 ALA CA 203 LYS CA 239 1YGD D 1YGDD FGDLSTPDAVMGNPK THR CA 284 1YGD D 1YGD

  19. AcEST: BP918906 [AcEST

    Lifescience Database Archive (English)

    Full Text Available LVKLMDRSGPVIDQLSNEVASETLHACCP 390 Query: 217 LLRQQKYFEICFAWIQQVADLVVS---DGMDFSENVKKELLLSLQE-RVATSMIADSSGT 50...ANELLHTVAH 218 W+ W + ++ DM+SA++EVLST D +LV+LM R+GPV DQL++ A+E LH Sbjct: 331 WTSWTNAMDAFSVGDMDSAFSEVLSTGDDFL

  20. 60 Détermination d'une couche superficielle de sol favorable au ...

    African Journals Online (AJOL)

    Samuel

    Nomenclature. : volume du ..... [9] - A. L. LOZANO, F. CHERBLANC, B. COUSIN and J.-C. BENET, European Journal of Soil Science 59 (2008). 939-949. ... [11] - A. BOUZAZA, C. VALLET and A. LAPLANCHE, Chemistry 177 (2006) 212-217.

  1. Teadlasena poliitikas - võimalused ja piirid = Als Wissenschaftler in der Politik - Chancen und Grenzen / Eiki Berg

    Index Scriptorium Estoniae

    Berg, Eiki, 1970-

    2005-01-01

    Autori hinnangul lasub teadlasel poliitikas suurem vastutus kui mistahes valdkonna esindajal, sest teaduslikult argumenteeritud poliitilised otsused on teadmiste jõu ja poliitilise võimu sümbioos. Vt. ka kommentaare lk. 217-222,467-472

  2. Gclust Server: 95461 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available ter sequences Cluster Sequences Link to related sequences Related Sequences(217) Sequence length 899 Representative...1 Clustering threshold 1.00e-99 Plants and algae (7species) (%) 0.0 Other Bikonts (Chromalveolata, Excavata)

  3. BIOMASS, SPECIES IDENTIFICATION, SPECIES IDENTIFICATION - LIFE STAGE, TAXONOMIC CODE and species abundance tows data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-14 to 2004-10-08 (NODC Accession 0113956)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113956 includes tows and biological data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211, HX215, HX217,...

  4. 47 CFR 80.385 - Frequencies for automated systems.

    Science.gov (United States)

    2010-10-01

    ... the United States Navy's SPASUR radar system (216.88-217.08 MHz) or to TV reception within the Grade B... Commission on a case-by-case basis upon submission of a technical analysis indicating that at least 18...

  5. 76 FR 61956 - Endangered and Threatened Wildlife and Plants; Endangered Status for the Ozark Hellbender Salamander

    Science.gov (United States)

    2011-10-06

    ..., including Beaver, Table Rock, Bull Shoals, and Norfork Reservoirs. North Fork White River--The North Fork....8 to 21.7 in (172 to 551 millimeters (mm)), indicating that reproduction was occurring in...

  6. ORIGINAL ARTICLE 210

    African Journals Online (AJOL)

    boaz

    18 (4): 210-217. TRANSCRIPTIONAL FACTOR INFLUENCE ON OTA PRODUCTION AND THE QUELLING ATTRIBUTE ... carcinogen following experiments on animals [1,2]. ... security. Some studies suggest that the mycotoxin biosynthesis.

  7. Measuring the food environment: shelf space of fruits, vegetables, and snack foods in stores

    National Research Council Canada - National Science Library

    Farley, Thomas A; Rice, Janet; Bodor, J Nicholas; Cohen, Deborah A; Bluthenthal, Ricky N; Rose, Donald

    2009-01-01

    .... We conducted measurements of the length of shelf space used for fruits, vegetables, and snack foods items in 419 stores in 217 urban census tracts in southern Louisiana and in Los Angeles County...

  8. Attachment study of Agrobacterium tumefaciens to yam spp

    African Journals Online (AJOL)

    Charles S.Wortmann

    Phenotypic coefficient of variation (PCV) was slightly higher than genotypic coefficient of ... India as centres of origin. Vavilov (1951) and ... development of lathyrism, a crippling disorder, in humans. ...... Crop Evolution 42:217–222. 18. Thorpe ...

  9. 76 FR 62498 - Finger Lakes Railway Corp.-Acquisition and Operation Exemption-CSX Transportation, Inc.

    Science.gov (United States)

    2011-10-07

    ... line of railroad extending between milepost QCS 2.88 and milepost QCS 3.61 near Solvay, Onondaga County... 2.17 miles of track in the Solvay Yard, which is adjacent to the subject rail line, but further...

  10. Effects of hypoxia on serum hepatic chemistries of Tibet chicken and ...

    African Journals Online (AJOL)

    aghomotsegin

    2013-11-13

    Nov 13, 2013 ... Key words: Hypoxia adaptation, liver metabolism, serum chemistry, Tibet chicken, chicken embryo. .... metabolism. Br. J. Cancer 62(2):217-225. Kallwitz ... enzymes and histology in obese patients with obstructive sleep apnea.

  11. Vsjak telefon prinossit dohhod / Viktoria Jürmann

    Index Scriptorium Estoniae

    Jürmann, Viktoria

    2007-01-01

    Kommunikatsiooniettevõtte Eesti Telekom puhaskasum esimesel poolaastal oli 548 miljonit krooni, mis on 21,7 % suurem võrreldes eelmise aasta sama perioodiga, investeeringud on mullusega võrreldes vähenenud

  12. EST Table: FS879118 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available milar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effet...se) (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum] FS793905 ftes ...

  13. EST Table: CK514954 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effet... (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum] FS793905 swj ...

  14. EST Table: CK544577 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effet... (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum] FS793905 swh ...

  15. 78 FR 5424 - Applications for New Awards; Indian Education-Professional Development Grants Program

    Science.gov (United States)

    2013-01-25

    ... 1978 (25 U.S.C. 1801 et seq.), and Dine College (formerly Navajo Community College), authorized in the... 34 CFR 75.217(d)(3), the past performance of the applicant in carrying out a previous award, such...

  16. A tale of three cities: Insight into the impacts of holiday rentals in ...

    African Journals Online (AJOL)

    Research in Hospitality Management ... apartments is important, though the favourable costs when compared with hotel stays was also valued. In Paris, the rented accommodation spend by tourists is estimated to be as much as €217 140 000.

  17. 78 FR 34143 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-06-06

    ... and no convictions for moving violations in a CMV. Steve Garrett Mr. Garrett, 40, has had a retinal... perform his job.'' Mr. Morgan reported that he has driven straight trucks for 12 years, accumulating 217...

  18. 18 CFR 157.207 - General reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL... specified in § 157.217(b); (g) For each change in customer name authorized under § 157.218, the...

  19. La violencia, el Estado y las clases sociales

    Directory of Open Access Journals (Sweden)

    Gonzalo Sánchez Gómez

    2011-12-01

    Full Text Available Violencia, Conflicto y Politica en Colombia,Paul Oquist. Ed. Instituto de Estudios Colombianos Biblioteca Banco Popular; Bogota, 1978; 339 pags. / Violencia y Desarrollo, Darlo Fajardo. Fondo Editorial Suramerica, Bogota, 1979; 217 paga.

  20. Field Plot and Observation Points for Dinosaur National Monument Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — This point file displays the 727 vegetation plots and 217 observation points visited in 2002, 2003 and 2004 as part of the vegetation mapping project. Plots and...

  1. 75 FR 28019 - Resmethrin; Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations

    Science.gov (United States)

    2010-05-19

    ..., recreational, and residential areas to control flying and crawling insects. All remaining resmethrin end use... reproduction 2.1.7 Hershberger (rat) 2.1.8 Female Pubertal (rat) 2.1.9 Male pubertal (rat)...

  2. Why Are Drugs So Hard to Quit?

    Medline Plus

    Full Text Available ... a control tower that sends out signals to direct your actions and choices. Addiction changes the signals ... 02. TEDMED 217,219 views 19:02 The Science of Addiction: Here's Your Brain on Drugs | National ...

  3. 78 FR 9771 - Federal Highway Administration

    Science.gov (United States)

    2013-02-11

    ... Federal Highway Administration Notice of Final Federal Agency Action on Proposed Transportation Project in Illinois and Indiana AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of limitation on..., Federal Highway Administration, 3250 Executive Park Drive, Springfield, Illinois 62703, Phone: (217)...

  4. Reference: IDRSZMFER1 [PLACE

    Lifescience Database Archive (English)

    Full Text Available tial involvement of the IDRS cis-element in the developmental and environmental regulation of the AtFer1 ferritin gene from Arabidopsis. Planta. 217: 709-716 (2003) PubMed: 12728319 ...

  5. 76 FR 79064 - New Animal Drugs; Change of Sponsor; Zinc Gluconate

    Science.gov (United States)

    2011-12-21

    ... new animal drug application (NADA) for zinc gluconate injectable solution from Technology Transfer... it has transferred ownership of, and all rights and interest in, NADA 141-217 for NEUTERSOL...

  6. Download this PDF file

    African Journals Online (AJOL)

    GB

    METHODS: Using cross sectional study design, a total of 217 female and 207 male participants were ... of resistance is < 10-20 percent and ciprofloxacin .... entire surface of Mueller-Hinton agar (Oxoid, ... the confidentiality of their responses.

  7. The pattern of diabetic admissions in UCTH Calabar, South Eastern ...

    African Journals Online (AJOL)

    Alasia Datonye

    the prevalence of diabetes especially in developing countries like Nigeria. Diabetes ... followed by DKA (21.7%) and diabetic foot syndrome. (15.8%). The duration of ..... 2007.30:20192024. 23. Alebiosu CO, Odusan O. Metabolic Syndrome in.

  8. Population and breeding success of Red-headed Vulture Sarcogyps ...

    African Journals Online (AJOL)

    Campbell Murn

    Periodic monitoring of each identified nest was done to determine breeding success ... Historical reports indicate Red- headed Vultures .... 24. 217. 241. Table 2: Age composition of Red-headed and Egyptian Vultures based on highest count.

  9. Drug: D03328 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D03328 Drug Carperitide (genetical recombination) (JAN); Carperitide (USAN/INN); Ha...l organs 21 Cardiovascular agents 217 Vasodilators 2179 Others D03328 Carperitide (genetical recombination)

  10. AcEST: BP917913 [AcEST

    Lifescience Database Archive (English)

    Full Text Available M88|A3XM88_9FLAO Acetyltransferase OS=Leeuwenhoekiella bla... 33 5.4 tr|Q9U0Z7|Q9U0Z7_LEIMA Hypothetical tra...88|A3XM88_9FLAO Acetyltransferase OS=Leeuwenhoekiella blandensis MED217 GN=MED217_07986 PE=4 SV=1 Length = 1

  11. A Preliminary Study of Reducing the Cost of Blast Shelter for Critical Workers

    Science.gov (United States)

    1983-08-01

    23 2.1.6 Luscher Study ..... ................. .... 28 2.1.7 Krupka Study ..... ................. .... 29 2.1.9 Haaland Study...a more reasonable cost/space number had been reported. 2.1.6 Ulrich Luscher - Behavior of Flexible Underground Cylinders, 1965 This study ( Luscher ...information about the utilization of corrugated culverts as blast shelters and modes of hardening. No cost analyses were discussed by Luscher . 2.1.7 R. A

  12. AcEST: BP913978 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 34 5.0 tr|A3XJS4|A3XJS4_9FLAO Pseudouridine synthase OS=Leeuwenhoekiell... 33 6.5...udouridine synthase OS=Leeuwenhoekiella blandensis MED217 GN=MED217_04192 PE=3 SV=1 Length = 265 Score = 33....GRIFS 398 +R+ + L+ S +G I+M R FS Sbjct: 136 DRDQASLDQSLADKG-ISMGSEAYNNALRDFS 166 >tr|A3XJS4|A3XJS4_9FLAO Pse

  13. Experiment list: SRX100401 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available d of PCR and an additional 15-cycle round of PCR after gel size selection (Myers) || controlid=SL217,SL218 |...al 15-cycle round of PCR after gel size selection (Myers) || replicate=1,2 || softwareversion=MACS || antibo...ent or protocol applies || protocol=PCR2x || protocol description=2-cycles of PCR (Myers) || controlid=SL217

  14. Tomato chlorotic leaf distortion virus, a new bipartite begomovirus infecting Solanum lycopersicum and Capsicum chinense in Venezuela.

    Science.gov (United States)

    Zambrano, Karla; Geraud-Pouey, Francis; Chirinos, Doris; Romay, Gustavo; Marys, Edgloris

    2011-12-01

    Virus isolate T217L was obtained from a diseased tomato (Solanum lycopersicum) plant showing leaf deformation and chlorotic mottle symptoms near Maracaibo in the state of Zulia, Venezuela. Full-length DNA-A and DNA-B molecules of T217L were cloned and sequenced. The genome organization of T217L was identical to the bipartite genomes of other begomoviruses described from the Americas. Characteristic disease symptoms were reproduced in S. lycopersicum and Capsicum annum plants inoculated using the cloned viral DNA-A and DNA-B components, confirming disease aetiology. A sequence analysis of DNA-A showed that the T217L isolate has the highest sequence identity (84%) with sida yellow mosaic Yucatan virus (SiYMYuV), sida golden mosaic Honduras virus (SiGMHV) and bean dwarf mosaic virus (BDMV) isolates. This is less than the 89% identity in the DNA-A component that has been defined as the threshold value for the demarcation of species in the genus Begomovirus. The molecular data show that isolate T217L belongs to a novel tentative begomovirus species, for which the name tomato chlorotic leaf distortion virus is proposed. TCLDV was also detected in symptomatic C. chinense plants growing near the T217L-infected plant.

  15. Liquid Scintillation Counting of Environmental Radioisotopes: A Review of the Impact of Background Reduction

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, Matthew; Bernacki, Bruce E.; Erchinger, Jennifer L.; Finn, Erin C.; Fuller, Erin S.; Hoppe, Eric W.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Orrell, John L.; Panisko, Mark E.; Warren, Glen A.; Wright, Michael E.

    2016-03-09

    Liquid scintillation counting (LSC) is a versatile and commonplace method for radiometric measurement of charged particle emitting radionuclides. The LSC method provides utility in a range of environmental science applications including hydrological studies of water transport, anthropogenic releases of radionuclides into the environment, and vertical mixing rates within oceans. Instrumental measurement background is one limiting factor of radiometric measurement sensitivity. As part of the development of a custom low background LSC system located in a shallow underground laboratory at Pacific Northwest National Laboratory, a number of measurement applications of LSC have been considered and are summarized here. The focus is on determining which aspects of such measurements would gain the greatest benefit from the reduction of LSC backgrounds by a factor of 10-100 relative to values reported in the literature. Examples of benefits include lowering the minimum detectable activity, reducing the sample size required, and shortening the elapsed timeline of the processing and analysis sequence. In particular tritium, strontium, and actinium isotopes are examined as these isotopes cover a range of requirements related to the LSC measurement method (e.g., 3H: low energy; Sr: spectral deconvolution; Ac: alpha/beta discrimination).

  16. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  17. Rutherford's curriculum vitae, 1894-1907.

    Science.gov (United States)

    Cohen, M

    1995-06-01

    A single page, handwritten document was discovered when the Macdonald Physics building of McGill University in Montreal was gutted in 1978. This proved to be the draft of Ernest Rutherford's curriculum vitae (C.V.) covering the years 1894-1907, probably written in the autumn of 1906 when Rutherford was preparing to leave McGill. The C.V. contains 21 headings in chronological order, referring to research and other activities of Rutherford and his coauthors (especially Soddy and Barnes), plus a further set of headings relating to the associated investigations of Rutherford's team, including Eve and Hahn. A transcript of the document is provided, although in several places, Rutherford's handwriting is difficult to interpret, and the significance of his abbreviations is not always clear. Each of the items in the C.V. is discussed briefly in this review, in the light both of Rutherford's personal career and of the contribution of his team to the development and understanding of radioactivity. This contribution included the cause and nature of radioactivity (with Soddy), energy aspects of radioactive decay (with Barnes), elucidation of the uranium-radium, thorium and actinium series (Godlewski and Hahn), the radioactivity of the earth and atmosphere (Eve), the nature of the gamma rays (Eve) and, perhaps most important of all, the nature and properties of the alpha particle (Rutherford himself). The latter investigations led directly to Rutherford's later work in Manchester, including the nuclear model of the atom and artificial disintegration of the nucleus.

  18. Development of an Ultra-Low Background Liquid Scintillation Counter for Trace Level Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Erchinger, Jennifer L.; Orrell, John L.; Aalseth, Craig E.; Bernacki, Bruce E.; Douglas, Matthew; Finn, Erin C.; Fuller, Erin S.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Panisko, Mark E.; Shaff, Sarah M.; Warren, Glen A.; Wright, Michael E.

    2015-09-01

    Low-level liquid scintillation counting (LSC) has been established as one of the radiation detection techniques useful in elucidating environmental processes and environmental monitoring around nuclear facilities. The Ultra-Low Background Liquid Scintillation Counter (ULB-LSC) under construction in the Shallow Underground Laboratory at Pacific Northwest National Laboratory aims to further reduce the MDAs and/or required sample processing. Through layers of passive shielding in conjunction with an active veto and 30 meters water equivalent overburden, the background reduction is expected to be 10 to 100 times below typical analytic low-background liquid scintillation systems. Simulations have shown an expected background of around 14 counts per day. A novel approach to the light collection will use a coated hollow light guide cut into the inner copper shielding. Demonstration LSC measurements will show low-energy detection, spectral deconvolution, and alpha/beta discrimination capabilities, from trials with standards of tritium, strontium-90, and actinium-227, respectively. An overview of the system design and expected demonstration measurements will emphasize the potential applications of the ULB-LSC in environmental monitoring for treaty verification, reach-back sample analysis, and facility inspections.

  19. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    NA

    2004-11-22

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this modeling activity is to predict dissolved concentrations or solubility limits for 14 elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) important to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are in the form of tabulated functions with pH and log (line integral) CO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. The output data from this report are fundamental inputs for Total System Performance Assessment for the License Application (TSPA-LA) to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for all of the actinides. These models cover broad ranges of environmental conditions so that they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or otherwise addressed.

  20. Purification of lanthanides for double beta decay experiments

    Energy Technology Data Exchange (ETDEWEB)

    Polischuk, O. G. [Institute for Nuclear Research, MSP 03680 Kyiv, Ukraine and INFN, Section of Rome, La Sapienza, I-00185 Rome (Italy); Barabash, A. S. [Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Belli, P. [INFN, Section of Rome Tor Vergata, I-00133 Rome (Italy); Bernabei, R. [INFN, Section of Rome Tor Vergata, I-00133 Rome, Italy and Department of Physics, University of Rome Tor Vergata, I-00133 Rome (Italy); Boiko, R. S.; Danevich, F. A.; Mokina, V. M.; Poda, D. V.; Tretyak, V. I. [Institute for Nuclear Research, MSP 03680 Kyiv (Ukraine); Cappella, F.; Incicchitti, A. [INFN, Section of Rome La Sapienza, I-00185 Rome, Italy and Department of Physics, University of Rome La Sapienza, I-00185 Rome (Italy); Cerulli, R.; Laubenstein, M.; Nisi, S. [INFN, Gran Sasso National Laboratories, I-67100 Assergi (Aq) (Italy)

    2013-08-08

    There are several potentially double beta active isotopes among the lanthanide elements. However, even high purity grade lanthanide compounds contain {sup 238}U, {sup 226}Ra and {sup 232,228}Th typically on the level of ∼ (0.1 - 1) Bq/kg. The liquid-liquid extraction technique was used to remove traces of U, Ra and Th from CeO{sub 2}, Nd{sub 2}O{sub 3} and Gd{sub 2}O{sub 3}. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe γ spectrometry at the underground Gran Sasso National Laboratories of the INFN (Italy). After the purification the radioactive contamination of gadolinium oxide by Ra and Th was decreased at least one order of magnitude. The efficiency of the approach to purify cerium oxide from Ra was on same level, while the radioactive contamination of neodymium sample before and after the purification is below the sensitivity of analytical methods. The purification method is much less efficient for chemically very similar radioactive elements like lanthanum, lutetium and actinium. R and D of the methods to remove the pollutions with improved efficiency is in progress.

  1. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin.

    Science.gov (United States)

    Nour, S; El-Sharkawy, A; Burnett, W C; Horwitz, E P

    2004-12-01

    The objective of this work was to establish a new procedure for 228Ra determination of natural waters via preconcentration of radium on MnO2 and separation of its daughter, 228Ac, using Diphonix ion exchange resin. Following removal of potential interferences via passage through an initial Diphonix Resin column, the first daughter of 228Ra, 228Ac, is isolated by chromatographic separation via a second Diphonix column. A holding time of > 30 h for 228Ac ingrowth in between the two column separations ensures secular equilibrium. Barium-133 is used as a yield tracer. Actinium-228 is eluted from the second Diphonix Resin with 5 ml 1M 1-Hydroxyethane-1,1-diphosphonic acid (HEDPA) and quantified by addition of scintillation cocktail and LSC counting. Radium (and 133Ba) from the load and rinse solutions from the 2nd Diphonix column may be prepared for alpha spectrometry (for determination of 223Ra, 224Ra, and 226Ra) by BaSO4 microprecipitation and filtration. Decontamination tests indicate that U, Th, and Ra series nuclides do not interfere with these measurements, although high contents of 90Sr (90Y) require additional treatment for accurate measurement of 228Ra. Addition of stable Sr as a "hold back" carrier during the initial MnO2 preconcentration step was shown to remove most 90Sr interference.

  2. Soil and river sediments radionuclides monitoring at Aramar Experimental Center: an historical overview

    Energy Technology Data Exchange (ETDEWEB)

    Segre, Nadia; Fagundes, Rosane Correa, E-mail: nadia.segre@ctmsp.mar.mil.br [Centro Tecnologico da Marinha (CTM-SP/CEA/LARE), Ipero, SP (Brazil). Centro Experimental Aramar. Lab. Radioecologico; Moraes, Marco Antonio P.V. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    In order to evaluate possible effects to the environment resulting from the implementation of the Centro Tecnologico da Marinha - Centro Experimental Aramar (CTMSP-CEA) at Ipero in Sao Paulo state, Brazil, which came into operation in 1989, an Environmental Monitoring Program (PMA) was established in October, 1987. One of the aims of this program is to monitor the soil and river sediments radionuclides levels at CEA and beyond its boundary. The utilization of statistical tools to evaluate the results of radiometric environmental monitoring is a procedure required by National Nuclear Energy Commission (CNEN). The box plot is a simple statistical tool for displaying data. The central tendency and dispersion of the results as well as the observation of unusual results (outliers) in the dataset are easily visualized. Control chart is a graph that maps data and provides a picture of how a process is performing over time. A control chart always has a central line for the mean, an upper line for the upper control limit and a lower line for the lower control limit. Box plots and control charts were used to visualize the annual amount of natural uranium, lead-214, actinium-228 and lead-212 in soil and river sediment detected between 1987 and 2011, considering the measurements of all monitored places each year. This historical observation shows that, in average, the results obtained are below than the 1987-1988 levels (CEA's pre-operational) or below than the backgrounds radionuclides values. (author)

  3. Background radiation and individual dosimetry in the costal area of Tamil Nadu, India.

    Science.gov (United States)

    Matsuda, Naoki; Brahmanandhan, G M; Yoshida, Masahiro; Takamura, Noboru; Suyama, Akihiko; Koguchi, Yasuhiro; Juto, Norimichi; Raj, Y Lenin; Winsley, Godwin; Selvasekarapandian, S

    2011-07-01

    South coast of India is known as the high-level background radiation area (HBRA) mainly due to beach sands that contain natural radionuclides as components of the mineral monazite. The rich deposit of monazite is unevenly distributed along the coastal belt of Tamil Nadu and Kerala. An HBRA site that laid in 2×7 m along the sea was found in the beach of Chinnavillai, Tamil Nadu, where the maximum ambient dose equivalent reached as high as 162.7 mSv y(-1). From the sands collected at the HBRA spot, the high-purity germanium semi-conductor detector identified six nuclides of thorium series, four nuclides of uranium series and two nuclides belonging to actinium series. The highest radioactivity observed was 43.7 Bq g(-1) of Th-228. The individual dose of five inhabitants in Chinnavillai, as measured by the radiophotoluminescence glass dosimetry system, demonstrated the average dose of 7.17 mSv y(-1) ranging from 2.79 to 14.17 mSv y(-1).

  4. Coupling of Uranium and Thorium Series Isotope Systematics for Age Determination of Late Pleistocene Zircons using LA-ICP-MS

    Science.gov (United States)

    Sakata, S.; Hirakawa, S.; Iwano, H.; Danhara, T.; Hirata, T.

    2014-12-01

    Zircon U-Th-Pb dating method is one of the most important tools for estimating the duration of magmatism by means of coupling of uranium, actinium and thorium decay series. Using U-Pb dating method, its reliability is principally guaranteed by the concordance between 238U-206Pb and 235U-207Pb ages. In case of dating Quaternary zircons, however, the initial disequilibrium effect on 230Th and 231Pa should be considered. On the other hands, 232Th-208Pb dating method can be a simple but powerful approach for investigating the age of crystallization because of negligible influence from initial disequilibrium effect. We have developed a new correction model for accurate U-Pb dating of the young zircon samples by taking into consideration of initial disequilibrium and a U-Pb vs Th-Pb concordia diagram for reliable age calibration was successfully established. Hence, the U-Th-Pb dating method can be applied to various zircons ranging from Hadean (4,600 Ma) to Quaternary (~50 ka) ages, and this suggests that further detailed information concerning the thermal history of the geological sequences can be made by the coupling of U-Th-Pb, fission track and Ar-Ar ages. In this presentation, we will show an example of U-Th-Pb dating for zircon samples from Sambe Volcano (3 to 100 ka), southwest Japan and the present dating technique using LA-ICP-MS.

  5. Pulse-shape discrimination and energy quenching of alpha particles in Cs$_2$LiLaBr$_6$:Ce$^{3+}$

    CERN Document Server

    Mesick, Katherine E; Stonehill, Laura C

    2016-01-01

    Cs$_2$LiLaBr$_6$:Ce$^{3+}$ (CLLB) is an elpasolite scintillator that offers excellent linearity and gamma-ray energy resolution and sensitivity to thermal neutrons with the ability to perform pulse-shape discrimination (PSD) to distinguish gammas and neutrons. Our investigation of CLLB has indicated the presence of intrinsic radioactive alpha background that we have determined to be from actinium contamination of the lanthanum component. We measured the pulse shapes for gamma, thermal neutron, and alpha events and determined that PSD can be performed to separate the alpha background with a moderate figure of merit of 0.98. We also measured the electron-equivalent-energy of the alpha particles in CLLB and simulated the intrinsic alpha background from $^{227}$Ac to determine the quenching factor of the alphas. A linear quenching relationship $L_{\\alpha} = E_{\\alpha} \\times q + L_0$ was found at alpha particle energies above 5 MeV, with a quenching factor $q = 0.71$ MeVee/MeV and an offset $L_0 = - 1.19$ MeVee.

  6. An Ion Exchange Study of Possible Hydridized 5f Bonding in theActinides

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, R.M.; Street, Jr., K.; Seaborg, G.T.

    1951-08-28

    A study has been made of the elution behavior of curium(III), americium(III), plutonium(III), actinium(III), plutonium(IV), neptunium(IV), uraniuM(IV), thorium(IV), neptunium(V), plutonium (VI), uranium (VI), lanthanum(III), cerium(III), europium(III), ytterbium(III), ytterium(III), strontium(II), barium(II), radium(II), cesium(I) with 3.2 M, 6.2 M, 9.3 M, and 12.2 M HCl solutions from Dowex-50 cation exchange resin columns. These elutions show that in high concentrations of hydrochloric acid the actinides form complex ions with chloride ion to a much greater extent than the lanthanides. The strengths of the tripositive actinide complex ions apparently go in the order plutonium > americium> curium, although their ionic radii also decrease in this same order. To explain these results, a partial covalent character may be ascribed to the bonding in the transuranium complex ions. It is shown that a reasonable structure for such covalent bonding involves hybridization of the 5f orbitals in the actinide elements.

  7. Electronic structure and dynamics of ordered clusters with ME or RE ions on oxide surface

    Energy Technology Data Exchange (ETDEWEB)

    Kulagin, N.A., E-mail: nkulagin@bestnet.kharkov.u [Kharkiv National University for Radio Electronics, Avenue Shakespeare 6-48, 61045 Kharkiv (Ukraine)

    2011-03-15

    Selected data of ab initio simulation of the electronic structure and spectral properties of either cluster with ions of iron, rare earth or actinium group elements have been presented here. Appearance of doped Cr{sup +4} ions in oxides, Cu{sup +2} in HTSC, Nd{sup +2} in solids has been discussed. Analysis of experimental data for plasma created ordered structures of crystallites with size of about 10{sup -9} m on surface of separate oxides are given, too. Change in the spectroscopic properties of clusters and nano-structures on surface of strontium titanate crystals discussed shortly using the X-ray line spectroscopy experimental results. - Research highlights: External influence and variation of technology induce changes in valence of nl ions in compounds. Wave function of cluster presented as anti-symmetrical set of ions wave functions. The main equation describes the self-consistent field depending on state of all electrons of cluster. Level scheme of Cr{sup 4+} ions in octo- and tetra-site corresponds to doped oxides spectra after treatment. Plasma treatment effects in appearance of systems of unit crystallites with size of about 10{sup -6}-10{sup -9} m.

  8. Immunization against Egyptian Schistosoma mansoni infection by multivalent DNA vaccine

    Institute of Scientific and Technical Information of China (English)

    Mahmoud H Romeih; Hanem M Hassan; Tarek S Abou Shousha; Mohamed A Saber

    2008-01-01

    The development of multivalent vaccines consisting of several antigens is a novel approach to creating broad-range protection against different parasite strains and parasite life cycle stages. We have previously confirmed that the schistosome Sm21.7 and SmFimbrin (SmFim) proteins could induce protection in mice. Therefore, this study aimed to construct the multivalent DNA vaccine Sm21.7-SmFim/pBudCE4.1 and evaluate its immune efficacy. The open reading frames of two Schistosoma mansoni genes, Sm21.7 and SmFim, were inserted into the eukaryotic expression plasmid pBudCE4.1 designed for the independent expression of two genes in mammalian cells. To evaluate the in vitro expression of the multivalent Sm21.7-SmFim/pBudCE4.1 DNA vaccine and its immunological effect in mice, the recombinant plasmid Sm21.7-SmFim/pBudCE4.1 was used to transfect 293T cells, and the expression of mRNA and proteins was examined using reverse transcription-polymerase chain reaction and Western blot analysis. Then the ability of Sm21.7.SmFim/pBudCE4.1 to protect against S. mansoni challenge infections was analyzed according to worm burden and egg reduction rates after vaccination of mice. Vaccinated mice showed a significant level of protection (56%), and a decrease in the number and size, and change in the cellular profile, of granulomas. Egg reduction in liver and intestine was 41.53% and 55.63%,respectively, as determined relative to mice that received the empty vector only. In addition to reductions in worm viability,worm fecundity and egg hatching ability were observed following challenge infection in the immunized group.Results showed that Sm21.7-SmFim/pBudCE4.1 could express Sm 21.7 and SmFim mRN A and proteins. Enzyme-linked immunosorbent assay and Western blot analysis indicated that immunized mice generated specific immunoglobulin G against Sm21.7-SmFim/pBudCE4.1. These results suggest that vaccination with multivalent S. mansoni DNA vaccine (SmFim-Sm21.7/pBudCE4.1) not only induces a

  9. Modeling Sorption and Degradation of 17β-Estradiol-17-Sulfate in Agricultural Soils

    Science.gov (United States)

    Bai, X.; Casey, F. X.; Hakk, H.; Shrestha, S. L.; DeSutter, T.; Khan, E.; Oduor, P. G.

    2011-12-01

    The natural steroid hormone, 17β-estradiol (E2), can be an endocrine disruptor at part-per trillion levels. Laboratory studies indicate a low potential for E2 persistence and mobility in the environment; however, field studies consistently indicate the presence of E2 and its primary metabolite, estrone, at levels sufficiently high to impact water quality. To facilitate urine excretion, animals may release E2 as a sulfated conjugate, which would have a higher aqueous solubility than the parent compound. We hypothesize that E2 conjugates contribute to the detection of free estrogens in the environment. The objective of this study was to determine the sorption, degradation, and mobility of a model conjugate, 17β-estradiol-17-sulfate (E2-17S), in agricultural soils. Radiolabeled E2-17S ([14C]E2-17S) was chemically synthesized in a three-step process, and then batch experiments were conducted in natural and sterile soils. Additionally, soil organic carbon (OC) was varied (1.29 and 0.26%) to investigate its effect on the fate of [14C]E2-17S. Liquid scintillation counting (LSC) was used in concert with high performance liquid chromatography (HPLC) to detect and quantitate parent compound and metabolites of E2-17S in the aqueous and bound phases. Residual soil was combusted to determine non-extractable levels of 14C. The E2-17S was relatively stable in the aqueous phase for natural and sterile soils. Mono- and di- hydroxyl E2-17S were detected as metabolites of E2-17S in the aqueous phase above both sterile and natural soil. Deconjugation to form E2 was not observed in aqueous phase; however, E2 and estrone were extracted from both natural and sterile soils. A conceptual model was developed to simulate and identify the fate and transport processes of E2-17S. Organic carbon was found to be an important factor affecting the sorption and degradation of E2-17S in soils.

  10. Increased diuron resistance in the joint expression of mutations located at the DIU2, DIU3 and DIU4 loci of Saccharomyces cerevisiae.

    Science.gov (United States)

    Meunier, B; Colson, A M

    1989-02-01

    In Saccharomyces cerevisiae, diuron blocks the respiratory pathway at the level of the bc1 complex. Two mitochondrially inherited loci, DIU1 and DIU2, located in the cytochrome b gene, and two nuclearly inherited loci, DIU3 and DIU4, have previously been identified. The present work genetically characterizes two double mutants. One mutant, Diu-217, carries two nuclearly inherited mutations, diu3-217a and diu-217b; the second mutant, Diu-783, carries the previously described nuclear mutation diu3-783 and a mitochondrial mutation diu2-783. Each mutation, independent of its location, exhibits a weak diuron resistance. The joint expression of two or three mutations leads to a cumulative or a cooperative enhanced diuron-resistant phenotype.

  11. 先天性巨结肠及其类缘病的临床病理学分析%Hirschsprung's disease and its allied diseases: a clinicopathologic analysis

    Institute of Scientific and Technical Information of China (English)

    杨军; 刘妮; 康安静; 陈晓黎; 靳耀锋; 苏宝山; 黄莺

    2012-01-01

    目的 回顾性分析先天性巨结肠症(HD)及其类缘病(HAD)的组织病理学特征.方法 按照HD和HAD病理诊断标准,回顾性分析217例临床诊断为巨结肠患者的病理切片.进行病理学诊断.结果 217例临床诊断为巨结肠的病例中,典型HD仅占41.47% (90/217),男女比例为8∶1;HAD占58.53%(127/217),男女比例为2.85∶1.结论 按照HD和HAD病理学诊断标准,临床上表现为巨结肠的患儿中58.53%的病例为HAD,HAD与HD患儿男女比例明显不同,提示两者可能具有不同的发病机制.%Objective To investigate clinical and histopathological characteristics of Hirschsprung's disease (HD) and HD allied disease (HAD) by a retrospective analysis.Methods Records of 217 cases clinical diagnosed as megacolon were retrospectively analyzed according to the standard for HD and HAD pathologic diagnosis.Results Among the 217 cases, 90 (41. 47% ) cases were typical HD, and the sex ratio was 8: 1 ;. 127 (58. 53% ) cases were HAD, and the sex ratio was of 2. 85: 1. Conclusion Totally 58. 53% of cases are HAD in the cases clinically diagnosed as megacolon. At the same time, HAD cases have a different sex ratio from typical HD case, suggesting that they may have a different pathogenesis.

  12. Transmitted Drug Resistance Among Recently Diagnosed Adults and Children in São Paulo, Brazil.

    Science.gov (United States)

    Guimarães, Paula Morena de Souza; Ferreira, João Leandro de Paula; Coelho, Luana Portes Ozório; Cavalcanti, Jaqueline de Souza; Lopes, Giselle Ibette Silva Lopez; Matsuda, Elaine Monteiro; Almeida, Flávia Jacqueline; Almeida, Valéria Correia; Campeas, Alexandre Ely; Junior, Luiz Carlos Pereira; Brígido, Luís Fernando de Macedo

    2015-12-01

    Transmitted drug resistance mutations (TDRM) have been a constant threat to treatment efficacy. We evaluated TDRM in plasma RNA of 217 antiretroviral therapy-naive patients from sites in the São Paulo metropolitan area, collected from 2012 to 2014. The partial HIV-1 polymerase region was sequenced using Big Dye terminators at an ABI 3130 Genetic Analyzer. TDRM was defined according to the Stanford database calibrated population resistance (CPR v.6.0), but other drug resistance mutations (DRM) considered at the IAS list (IAS, 2014) and at the Stanford HIV Database Genotyping Resistance Interpretation (GRI-HIVdb) were also described. Out of 78% (170/217) of patients with information on the time of diagnosis, most (83%, 141/170) had been recently diagnosed, with the first positive HIV serology at a median of 58 days (IQR 18-184). Subtype B predominated (70%), followed by subtype F (10%), BF (7.5%), C (7.5%), and BC (5%). TDRMs were observed in 9.2% (20/217, CI 95% 5.9% to 13.6%), mostly (5.2%) to nonnucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral class. Among children and adolescents, only a single patient showed TDRMs. Additional non-CPR mutations were observed: 11.5% (25/217) according to IAS or 4.6% (10/217) according to GRI-HIVdb. Overall, 23.5% (51/217) of the cases had one or more DRM identified. TDRM prevalence differed significantly among some sites. These trends deserve continuous and systematic surveillance, especially with the new policies of treatment as prevention being implemented in the country.

  13. 78 FR 78508 - Quarterly Rail Cost Adjustment Factor

    Science.gov (United States)

    2013-12-26

    ...-inclusive index of railroad input prices ] and the method for computing the rail cost adjustment factor... 208.7 5 DEPRECIATION 11.9 221.0 217.8 6 INTEREST 2.0 76.6 76.6 7 OTHER ITEMS \\2\\ 21.9 220.0 220.5 8... EQUIPMENT RENTS 5.6 208.0 207.6 5 DEPRECIATION 11.5 218.9 217.8 6 INTEREST 2.3 87.3 87.3 7 OTHER ITEMS...

  14. AcEST: DK961846 [AcEST

    Lifescience Database Archive (English)

    Full Text Available LKAPKFDLMKLMEVHGDYSEEVGAKIERPV 253 Query: 286 AEDAEPKVE 260 ++AEP E Sbjct: 254 GDEAEPAAE 262 >tr|A0N0S0|A0N0S0_9ASPA RPS3 OS=Cymbidiu...olanum... 217 6e-55 tr|A9TFE1|A9TFE1_PHYPA Predicted protein OS=Physcomitrella paten... 217 6e-55 tr|A0N0S0|A0N0S0_9ASPA RPS3 OS=Cymb...idium hybrid cultivar PE=2 SV=1 216 1e-54 tr|Q285L8|Q285

  15. Disease: H01071 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available a deficiency in the ALDH2 is associated with the alcohol flush reaction. More than 40% of the East Asians po...mes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. It is reported that ...ion in the enzymatic activity when compared with the wild-type allele. Inherited metabolic disease hsa00010(...217) Glycolysis / Gluconeogenesis ALDH2 [HSA:217] [KO:K00128] OMIM: 610251 PMID:16792555 Dickson PA, James MR, Hea...on at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans. Alcohol

  16. Physical Activity

    DEFF Research Database (Denmark)

    Andersen, Lars Bo; Anderssen, Sigmund Alfred; Wisløff, Ulrik

    2014-01-01

    Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers.......Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers....

  17. 涤棉品种应用部分醇解PVA的浆纱实践%Sizing Practice of Using Partial Alcoholysis PVA in Polyester Cotton Variety

    Institute of Scientific and Technical Information of China (English)

    梁新乾; 朱亚慧

    2007-01-01

    为了减少涤棉混纺产品浆料配方中PVA的用量,降低上浆成本,应用PVA-217SB低醇解度PVA、润力浆料进行了上浆实践.结果表明:应用PVA-217SB低醇解度PVA、润力浆料上浆后,减少了PVA用量,提高了浆纱质量,减少了经向断头,提高了织机效率,并且降低了用浆成本.

  18. Spectral Estimation: An Overdetermined Rational Model Equation Approach.

    Science.gov (United States)

    1982-09-15

    procedure. This method was developed by Levinson and is commonly referred to as the Levinson- Durbin algorithm [24,[431. In this approach, one solves the...k-) /bo(k-l)1 2 (2.17a) ai (k) -i k)ai 1 j i k-1 (2.17b) Wb k 2 (k) 2((k-1)1 No r - (1 - lak I 11bok(12.17c Table 2.1. Levinson- Durbin Algorithm...a moderate mount of algebraic manipulation will reveal the validity of the solution as liven in Step 2 of Table 2.1 with k - 2 (with superscript (2

  19. Physical Activity

    DEFF Research Database (Denmark)

    Andersen, Lars Bo; Anderssen, Sigmund Alfred; Wisløff, Ulrik

    2014-01-01

    Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers.......Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers....

  20. Protein: FBA2 [TP Atlas

    Lifescience Database Archive (English)

    Full Text Available enzyme E2 D2 Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2(17)KB 2, Ubiquitin-conjugating en...zyme E2-17 kDa 2, Ubiquitin-protein ligase D2 9606 Homo sapiens P62837 7322 3TGD, 2ESP, 2ESO, 3JW0, 3L1Y, 2ESK, 2C4O, 2ESQ, 1UR6, 1W4U, 2CLW, 3JVZ 3A33 7322 P62837 20152160 #20100118 ...

  1. Drug: D01573 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01573 Drug Etilefrine hydrochloride (JP16); Etilefrine hydrochloride (TN) C10H15NO...2. HCl 217.087 217.6925 D01573.gif Antihypotensive; Sympathomimetic Therapeutic category: 2119 ATC code: C01CA01 alpha1-adr...tion hsa04270(146+147+148) Vascular smooth muscle contraction hsa04970(146+147+148) Salivary secretion Therapeutic category of dr... 211 Cardiotonics 2119 Others D01573 Etilefrine hydrochloride (JP16) Anatomical T...AC STIMULANTS EXCL. CARDIAC GLYCOSIDES C01CA Adrenergic and dopaminergic agents C01CA01 Etilefrine D01573 Etilefrine hydr

  2. An aerial radiological survey of the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Hendricks, T J; Riedhauser, S R

    1999-12-01

    A team from the Remote Sensing Laboratory conducted an aerial radiological survey of the US Department of Energy's Nevada Test Site including three neighboring areas during August and September 1994. The survey team measured the terrestrial gamma radiation at the Nevada Test Site to determine the levels of natural and man-made radiation. This survey included the areas covered by previous surveys conducted from 1962 through 1993. The results of the aerial survey showed a terrestrial background exposure rate that varied from less than 6 microroentgens per hour (mR/h) to 50 mR/h plus a cosmic-ray contribution that varied from 4.5 mR/h at an elevation of 900 meters (3,000 feet) to 8.5 mR/h at 2,400 meters (8,000 feet). In addition to the principal gamma-emitting, naturally occurring isotopes (potassium-40, thallium-208, bismuth-214, and actinium-228), the man-made radioactive isotopes found in this survey were cobalt-60, cesium-137, europium-152, protactinium-234m an indicator of depleted uranium, and americium-241, which are due to human actions in the survey area. Individual, site-wide plots of gross terrestrial exposure rate, man-made exposure rate, and americium-241 activity (approximating the distribution of all transuranic material) are presented. In addition, expanded plots of individual areas exhibiting these man-made contaminations are given. A comparison is made between the data from this survey and previous aerial radiological surveys of the Nevada Test Site. Some previous ground-based measurements are discussed and related to the aerial data. In regions away from man-made activity, the exposure rates inferred from the gamma-ray measurements collected during this survey agreed very well with the exposure rates inferred from previous aerial surveys.

  3. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization.

    Directory of Open Access Journals (Sweden)

    Jaspreet Singh Jaggi

    Full Text Available BACKGROUND: Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen and drug delivery and results in radiotherapy and chemotherapy resistance, respectively. Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature. METHODOLOGY AND PRINCIPAL FINDINGS: Actinium-225 ((225Ac-E4G10, an alpha-emitting antibody construct reactive with the unengaged form of vascular endothelial cadherin, is capable of potent, selective killing of tumor neovascular endothelium and late endothelial progenitors in bone-marrow and blood. No specific normal-tissue uptake of E4G10 was seen by imaging or post-mortem biodistribution studies in mice. In a mouse-model of prostatic carcinoma, (225Ac-E4G10 treatment resulted in inhibition of tumor growth, lower serum prostate specific antigen level and markedly prolonged survival, which was further enhanced by subsequent administration of paclitaxel. Immunohistochemistry revealed lower vessel density and enhanced tumor cell apoptosis in (225Ac-E4G10 treated tumors. Additionally, the residual tumor vasculature appeared normalized as evident by enhanced pericyte coverage following (225Ac-E4G10 therapy. However, no toxicity was observed in vascularized normal organs following (225Ac-E4G10 therapy. CONCLUSIONS: The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy.

  4. Evaluation of naturally occurring radioactive materials (NORMs) in inorganic and organic oilfield scales from the Middle East.

    Science.gov (United States)

    Bassioni, Ghada; Abdulla, Fareed; Morsy, Zeinab; El-Faramawy, Nabil

    2012-04-01

    The distribution of natural nuclide gamma-ray activities and their respective annual effective dose rates, produced by potassium-40 (⁴⁰K), uranium-238 (²³⁸U), thorium-232 (²³²Th), and radium-226 (²²⁶Ra), were determined for 14 oilfield scale samples from the Middle East. Accumulated radioactive materials concentrate in tubing and surface equipment, and workers at equipment-cleaning facilities and naturally occurring radioactive materials (NORMs) disposal facilities are the population most at risk for exposure to NORM radiation. Gamma-spectra analysis indicated that photo-gamma lines represent the parents of 10 radioactive nuclides: ²³⁴Th, plutonium-239, actinium-228, ²²⁶Ra, lead-212 (²¹²Pb), ²¹⁴Pb, thallium-238 (²⁰⁸Tl), bismuth-212 (²¹²Bi), ²¹⁴Bi, and ⁴⁰K. These nuclides represent the daughters of the natural radioactive series ²³⁸U and ²³²Th with ⁴⁰K as well. The mean activity concentration of ²³⁸U, ²³²Th, and ⁴⁰K were found to be 25.8 ± 11.6, 18.3 ± 8.1, and 4487.2 ± 2.5% Bq kg⁻¹ (average values for 14 samples), respectively. The annual effective dose rates and the absorbed doses in air, both indoor and outdoor, for the samples were obtained as well. The results can be used to assess the respective hazard on workers in the field and represent a basis for revisiting current engineering practices.

  5. Alpha-emitting isotopes and chromium in a coastal California aquifer

    Science.gov (United States)

    Densmore, Jill N.; Izbicki, John A.; Murtaugh, Joseph M.; Swarzenski, Peter W.; Bullen, Thomas D.

    2014-01-01

    The unadjusted 72-h gross alpha activities in water from two wells completed in marine and alluvial deposits in a coastal southern California aquifer 40 km north of San Diego were 15 and 25 picoCuries per liter (pCi/L). Although activities were below the Maximum Contaminant Level (MCL) of 15 pCi/L, when adjusted for uranium activity; there is concern that new wells in the area may exceed MCLs, or that future regulations may limit water use from the wells. Coupled well-bore flow and depth-dependent water-quality data collected from the wells in 2011 (with analyses for isotopes within the uranium, actinium, and thorium decay-chains) show gross alpha activity in marine deposits is associated with decay of naturally-occurring 238U and its daughter 234U. Radon activities in marine deposits were as high as 2230 pCi/L. In contrast, gross alpha activities in overlying alluvium within the Piedra de Lumbre watershed, eroded from the nearby San Onofre Hills, were associated with decay of 232Th, including its daughter 224Ra. Radon activities in alluvium from Piedra de Lumbre of 450 pCi/L were lower than in marine deposits. Chromium VI concentrations in marine deposits were less than the California MCL of 10 μg/L (effective July 1, 2014) but δ53Cr compositions were near zero and within reported ranges for anthropogenic chromium. Alluvial deposits from the nearby Las Flores watershed, which drains a larger area having diverse geology, has low alpha activities and chromium as a result of geologic and geochemical conditions and may be more promising for future water-supply development.

  6. A survey of arsenic, manganese, boron, thorium, and other toxic metals in the groundwater of a West Bengal, India neighbourhood.

    Science.gov (United States)

    Bacquart, Thomas; Bradshaw, Kelly; Frisbie, Seth; Mitchell, Erika; Springston, George; Defelice, Jeffrey; Dustin, Hannah; Sarkar, Bibudhendra

    2012-07-01

    Around 150 million people are at risk from arsenic-contaminated groundwater in India and Bangladesh. Multiple metal analysis in Bangladesh has found other toxic elements above the World Health Organization (WHO) health-based drinking water guidelines which significantly increases the number of people at risk due to drinking groundwater. In this study, drinking water samples from the Bongaon area (North 24 Parganas district, West Bengal, India) were analyzed for multiple metal contamination in order to evaluate groundwater quality on the neighbourhood scale. Each sample was analyzed for arsenic (As), boron (B), barium (Ba), chromium (Cr), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), and uranium (U). Arsenic was found above the WHO health-based drinking water guideline in 50% of these tubewells. Mn and B were found at significant concentrations in 19% and 6% of these tubewells, respectively. The maps of As, Mn, and B concentrations suggest that approximately 75% of this area has no safe tubewells. The concentrations of As, Mn, B, and many other toxic elements are independent of each other. The concentrations of Pb and U were not found above WHO health-based drinking water guidelines but they were statistically related to each other (p-value = 0.001). An analysis of selected isotopes in the Uranium, Actinium, and Thorium Radioactive Decay Series revealed the presence of thorium (Th) in 31% of these tubewells. This discovery of Th, which does not have a WHO health-based drinking water guideline, is a potential public health challenge. In sum, the widespread presence and independent distribution of other metals besides As must be taken into consideration for drinking water remediation strategies involving well switching or home-scale water treatment.

  7. Dicty_cDB: Contig-U16028-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 150 2e-44 AC140034_6( AC140034 |pid:none) Medicago truncatula clone mth2-17g... 150 2e-44 AF410883_1( AF410883 |pid:none) Franklin...ralabidochromis chilotes isolate... 140 3e-44 AF410881_1( AF410881 |pid:none) Frankliniella occidentalis cys

  8. Personality and Gender Differences in Friendship Needs and Experiences in Preadolescence and Young Adulthood

    Science.gov (United States)

    Zarbatany, Lynne; Conley, Ryanne; Pepper, Susan

    2004-01-01

    Personality and gender differences in close same-sex friendship needs and experiences were investigated in two samples. Participants were 312 university students (217 women, M age = 19.5) and 491 preadolescents (269 girls, M age = 11.87). Participants completed several questionnaires yielding scores for communion and agency (personality), communal…

  9. Decision Under Conflict: Resolution and Confidence in Judgment and Choice

    Science.gov (United States)

    1992-08-05

    specifically, by an overpricing of the low probability bet (see Tversky, Slovic, & Kahneman, "The causes of preference reversal," American Economic Review , 1990...preference reversal. American Economic Review ,, 80, 204-217. Tversky, A., & Thaler, R. (1990). Anomalies: Preference reversals. Journal of Economic Perspectives, 4(2), 201-2111.

  10. Towards a Broader Conceptualization of Need, Stigma, and Barriers to Mental Health Care in Military Organizations: Recent Research Findings from the Canadian Forces

    Science.gov (United States)

    2011-04-01

    217-23. [11] Sareen J, Cox BJ, Afifi TO, Stein MB, Belik SL, Meadows G et al. Combat and peacekeeping operations in relation to prevalence of...screening of service members returning from Bosnia. J Appl Soc Psychol 2000;30:1599-618. [49] Sareen J, Cox BJ, Afifi TO, Stein MB, Belik SL, Meadows G

  11. Predicting Involuntary Separation of Enlisted Personnel.

    Science.gov (United States)

    1980-01-01

    involuntary separation 20 ABSTRACT tConinue on rev -.. side It rect.ssaty and id.. nif hy block rnmhirl ,This report contains lh’ results of a study to compare...Subsample Size - 1000 Predicted 1 593 204 590 217 Base Rate - 65% Predicted 0 57 146 ( A1 133 Classification Accuracy (7’) 73.9 72.3 Subsample Size

  12. Political Culture and the Nature of Political Participation in Egypt.

    Science.gov (United States)

    1980-06-01

    Nasser’s Egypt, Austin: Univ. of Texas Press, 1971. Meisel, J.H., The Myth of the Ruling Class: Gaetano Mosca and the Elite, Ann Arbor: Univ. of Michigan... Mosca called the "second strata of the ruling class" - the strata without which the leadership could not 27 rule (Meisel 1962, p. 217]. The clientage

  13. 78 FR 77587 - Waiver for Marking Sunken Vessels With a Light at Night

    Science.gov (United States)

    2013-12-24

    ... minutes, per waiver, to write up and submit a formal request to the District Commander. Therefore, the... Standards M. Environment I. Abbreviations BLS Bureau of Labor Statistics CFR Code of Federal Regulations... percent and an annualized cost of $217.32 discounted at 7 percent. \\1\\ See the Bureau of Labor Statistics...

  14. Tartu biomeditsiiniettevõtluse võimalused ja riiklikud poliitikad = Über die Möglichkeiten von Biomedizin-Unternehmen in Tartu und die staatliche Politik / Garri Raagmaa

    Index Scriptorium Estoniae

    Raagmaa, Garri, 1966-

    2005-01-01

    Teadmistepõhisest majandusest on küll palju räägitud, kuid selle sisu on jätkuvalt segane ja seetõttu ähvardab devalveeruda. Autori hinnangul on vaja enam kommunikatsiooni ning vastastikku arusaamist teadlaste, poliitikute ja ettevõtjate vahel. Vt. ka kommentaare lk. 217-222,467-472

  15. Politikberatung aus den Staatswissenschaften = Riigiteadus poliitikanõustajana / Jürgen Backhaus

    Index Scriptorium Estoniae

    Backhaus, Jürgen

    2005-01-01

    Teadmistepõhine poliitika eeldab, et teadmised, millele poliitika peab tuginema, on tõepoolest ka olemas ja et on olemas keegi, kes oskab neid poliitikuile efektiivselt edastada. Sotsiaalteaduste puhul kerkib esile probleem, et vastav kommunikatsioon on üha puudulikum, leiab autor. Vt. ka kommentaare lk. 217-222,467-472

  16. Middle Eastern Geographies of World War I

    Science.gov (United States)

    2010-05-21

    retain.131 Soon after the fall of Basra, Sir Percy Cox, Chief Political Officer to the campaign, and Lord Hardinge, the Viceroy of India, both made...34Why Geography Matters ... But So Little is Learned." Orbis 47, no. 2 (Spring 2003): 217- 233. McFate, Montgomery, and Andrea Jackson . "An

  17. The Differential Contribution of Maternal and Paternal Values to Social Competence of Preschoolers

    Science.gov (United States)

    Bigras, Marc; Crepaldi, Maria Aparecida

    2013-01-01

    Multivariate analyses were conducted to clarify the nature of the influences of parental values on social behaviours of kindergarteners in the context of socio-demographic variables and sex of participants. This study included 217 mothers and 172 fathers from the same families, who completed a socio-demographic questionnaire and a new Q-sort that…

  18. L2 Willingness to Communicate, Openness to Experience, Extraversion, and L2 Unwillingness to Communicate: The Iranian EFL Context

    Science.gov (United States)

    Khany, Reza; Nejad, Ali Mansouri

    2017-01-01

    This study examines the relationship between L2 willingness to communicate (L2WTC), L2 unwillingness to communicate (L2UWTC) and the personality traits of openness to experience and extraversion in an Iranian context. The Pearson correlation and descriptive statistics were used to analyse the results from a study with 217 English major students. A…

  19. Predictors of Changes in Body Image Concerns of Chinese Adolescents

    Science.gov (United States)

    Chen, Hong; Jackson, Todd

    2009-01-01

    This nine-month prospective study tested the extent to which risk factors implicated in recent accounts of body dissatisfaction predicted changes in body image concerns of adolescent boys and girls in China. A sample of 593 Chinese adolescents (217 boys, 376 girls) completed measures of weight esteem, appearance esteem and physical stature concern…

  20. Politikberatung aus den Staatswissenschaften = Riigiteadus poliitikanõustajana / Jürgen Backhaus

    Index Scriptorium Estoniae

    Backhaus, Jürgen

    2005-01-01

    Teadmistepõhine poliitika eeldab, et teadmised, millele poliitika peab tuginema, on tõepoolest ka olemas ja et on olemas keegi, kes oskab neid poliitikuile efektiivselt edastada. Sotsiaalteaduste puhul kerkib esile probleem, et vastav kommunikatsioon on üha puudulikum, leiab autor. Vt. ka kommentaare lk. 217-222,467-472

  1. Tartu biomeditsiiniettevõtluse võimalused ja riiklikud poliitikad = Über die Möglichkeiten von Biomedizin-Unternehmen in Tartu und die staatliche Politik / Garri Raagmaa

    Index Scriptorium Estoniae

    Raagmaa, Garri, 1966-

    2005-01-01

    Teadmistepõhisest majandusest on küll palju räägitud, kuid selle sisu on jätkuvalt segane ja seetõttu ähvardab devalveeruda. Autori hinnangul on vaja enam kommunikatsiooni ning vastastikku arusaamist teadlaste, poliitikute ja ettevõtjate vahel. Vt. ka kommentaare lk. 217-222,467-472

  2. Urn Automata

    Science.gov (United States)

    2003-11-05

    of deadlock or loss of synchronization. The Chemical Abstract Machine of Berry and Boudol [1] is an abstract machine designed to model a situation in...only small growth in the number of tokens? References [1] G. Berry and G. Boudol. The chemical abstract machine. Theoretical Computer Science, 96:217

  3. Computation in Networks of Passively Mobile Finite-State Sensors

    Science.gov (United States)

    2004-02-23

    in the case of conjugating automata. The Chemical Abstract Machine of Berry and Boudol [2] is an abstract machine designed to model a situation in...2003. [2] G. Berry and G. Boudol. The Chemical Abstract Machine. Theoretical Computer Science, 96:217–248, 1992. [3] D. Brand and P. Zafiropulo. On

  4. Time in U.S. Residency and the Social, Behavioral, and Emotional Adjustment of Latino Immigrant Families

    Science.gov (United States)

    Martinez, Charles R., Jr.; McClure, Heather H.; Eddy, J. Mark; Wilson, D. Molloy

    2011-01-01

    Little is known about contributors to positive social, behavioral, and emotional adjustment among foreign-born youth at different stages of adapting to life in the United States. Using baseline data from the Adolescent Latino Acculturation Study (N = 217), this article examines the effects of time in residency on parent adjustment, family stress,…

  5. Differences in injury risk and characteristics between Dutch amateur and professional soccer players

    NARCIS (Netherlands)

    Beijsterveldt, A.M.C. van; Stubbe, J.H.; Schmikli, S.L.; Port, I.G.L. van de; Backx, F.J.G.

    2015-01-01

    Objectives: To compare the incidence and characteristics of injuries between Dutch amateur and professional male soccer players during one entire competition season. Design: A prospective two-cohort design. Methods: During the 2009-2010 season, 456 Dutch male amateur soccer players and 217 professio

  6. Predictors of Changes in Body Image Concerns of Chinese Adolescents

    Science.gov (United States)

    Chen, Hong; Jackson, Todd

    2009-01-01

    This nine-month prospective study tested the extent to which risk factors implicated in recent accounts of body dissatisfaction predicted changes in body image concerns of adolescent boys and girls in China. A sample of 593 Chinese adolescents (217 boys, 376 girls) completed measures of weight esteem, appearance esteem and physical stature concern…

  7. Latent Classes of Externalizing Behaviors in Youth with Early Maltreatment Histories

    Science.gov (United States)

    Villodas, Miguel T.; Litrownik, Alan J.; Roesch, Scott C.

    2012-01-01

    Latent class analyses were used to identify subsets of 217 12-year-old youth with early maltreatment histories based on youth and caregiver reports of externalizing behavior problems. The identified classes were validated using symptom counts and diagnoses for disruptive behavior disorders collected from youth and caregiver reports 2 years later.…

  8. Drug repositioning and repurposing: terminology and definitions in literature

    NARCIS (Netherlands)

    Langedijk, Joris; Mantel-Teeuwisse, Aukje K; Slijkerman, Diederick S; Schutjens, Marie-Hélène D B

    2015-01-01

    Drug repositioning and similar terms have been a trending topic in literature and represent novel drug development strategies. We analysed in a quantitative and qualitative manner how these terms were used and defined in the literature. In total, 217 articles referred to 'drug repositioning', 'drug

  9. Managing urban parks for a racially and ethnically diverse clientele

    Science.gov (United States)

    Paul H. Gobster

    2002-01-01

    A major planning effort for Chicago's largest park provided an opprotunity yto examine outdoor recreation use patterns and preferences among a racially and ethnically diverse clientele. Results from on-site surveys of 898 park users (217 Black, 210 Latino, 182 Asian, and 289 White) showed that park users shared a core set of interests, preferences, and concerns...

  10. EST Table: FY002291 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY002291 bmov7h16 11/11/04 99 %/217 aa ref|NP_001037309.1| vitellogenin precursor [...s: Precursor dbj|BAA02444.1| vitellogenin precursor [Bombyx mori] dbj|BAA06397.1| vitellogenin [Bombyx mori]..._971398.1| PREDICTED: similar to vitellogenin [Tribolium castaneum] FS939370 bmov ...

  11. Value of endometrial thickness measurement for diagnosing focal intrauterine pathology in women without abnormal uterine bleeding

    DEFF Research Database (Denmark)

    Dreisler, E; Sorensen, S Stampe; Ibsen, P H;

    2009-01-01

    modulators (n = 2). Thus, 375 women without AUB were included (217 pre- and 158 postmenopausal). Receiver-operating characteristics (ROC) curves for endometrial thickness and focal lesion were analyzed. RESULTS: Focal intrauterine pathology was confirmed in 41 women (35 with polyps, five with submucosal...

  12. Biblical principles towards a pastoral strategy for poverty alleviation ...

    African Journals Online (AJOL)

    2014-04-15

    Apr 15, 2014 ... shelter, medical care, education, employment and clean water. ... For this reason, Maxwell (2005:217) states that these leaders have 'sinned against' ... Also, due to the influence of the prosperity ... Church unity from the perspective of the poor ..... frequently occurs in an ethical sense of human actions; good.

  13. Experiment list: SRX014770 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available on=Bone Marrow|Tissue Diagnosis=Leukemia 14403159,71.1,32.3,217 GSM468200: RAR ChIPseq NB4 24hoursATRA JM21 ...source_name=NB4 cells || agent=24 hours ATRA || antibody=RAR http://dbarchive.biosciencedbc.jp/kyushu-u/hg19

  14. AcEST: DK957088 [AcEST

    Lifescience Database Archive (English)

    Full Text Available S=Brucell... 211 2e-54 sp|B0CIU0|GLO2_BRUSI Hydroxyacylglutathione hydrolase OS=Brucell... 211 2e-54 sp|A5VSR1|GLO2_BRUO2...: 547 KYYSEVKELRQANRPTIPTS 606 + E+ LR R T+P++ Sbjct: 198 ERAKEIARLRAHERMTLPST 217 >sp|A5VSR1|GLO2_BRUO2 Hyd

  15. Dirac fermions in strong gravitational fields

    OpenAIRE

    Silenko, A. J.

    2013-01-01

    arXiv publications (http://lanl.arxiv.org) arXiv:1308.2610 Comments: 9 pages Journal-ref: JETP Letters 98, 217 (2013) Subjects: High Energy Physics - Experiment (hep-ex); Accelerator Physics (physics.acc-ph); Atomic Physics (physics.atom-ph)

  16. Regulatory Evaluation of Petroleum Hydrocarbons in Dredged Material: Proceedings of a Workshop Held in Vicksburg, Mississippi on 15-17 March 1988

    Science.gov (United States)

    1990-07-01

    ecology of lake plankton , algae 607 E. Peabody Drive as bioindicators Champaign, IL 61820-6970 217-333-6897 Dr. Anne Spacie Marine/freshwater chemistry...Vol 25, pp 99-124. Dunn, B. P. 1980. "Polycyclic Aromatic Hydrocarbons in Marine Sediments, Bivalves, and Seaweeds : Analysis by High-Pressure Liquid

  17. Factors guiding tsunami surge at the Nagapattinam–Cuddalore shelf, Tamil Nadu, east coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Murthy, K.S.R.; Subrahmanyam, A.S.; Murty, G.P.S.; Sarma, K.V.L.N.S.; Subrahmanyam, V.; Rao, K.M.; Rani, P.S.; Anuradha, A.; Adilakshmi, B.; Devi, T.S.

    . , 1992, 29 , 209 ? 217. ACKNOWLEDGEMENTS. We thank Dr Satish R. Shetye, Dire c tor, NIO, Goa for encouragement. Thanks are also due to the r e viewer for his su g gestions. This is NIO contribution no. 4134. Received 2 December 2005...

  18. EST Table: FY028533 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY028533 bmte20h17 11/11/04 99 %/217 aa ref|NP_001103794.1| calcyphosphine isoform ...1 [Bombyx mori] gb|ABF51310.1| calcyphosphine isoform 1 [Bombyx mori] 11/11/04 56 %/182 aa FBpp0173454|DmojG

  19. A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder

    Science.gov (United States)

    Handen, Benjamin L.; Melmed, Raun D.; Hansen, Robin L.; Aman, Michael G.; Burnham, David L.; Bruss, Jon B.; McDougle, Christopher J.

    2009-01-01

    Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind, placebo-controlled, parallel groups, dose-ranging study of oral, human immunoglobulin (IGOH 140, 420, or 840 mg/day) was utilized with 125 children (ages 2-17 years) with autism and persistent GI…

  20. Implications of the Chinese Anti-Satellite Test for the United States Navy Surface Forces

    Science.gov (United States)

    2008-09-01

    216 Freidman, Seapower and Space, 97. 217 Charles P. Vick, “Improved- Advanced Crystal/ IKON / “KH-12”,” Global Security, (April 25, 2007), http...Improved- Advanced Crystal/ IKON / “KH-12”.” Global Security, (April 25, 2007), http://www.globalsecurity.org, (accessed August 25, 2008). Waltz, Kenneth

  1. Birth Defects in Newborns: Spina Bifida Index at Rio Grande Do Norte State in Brazil

    Directory of Open Access Journals (Sweden)

    Arnaldo CM Junior

    2014-08-01

    Conclusion: Northeast region is the one that has the major incidence of SB in Brazil country, but RN state has a number lower than others states from its region. It was made an update about therapeutic options to minimize the morbidity and mortality in newborn with SB congenital defects. [J Interdiscipl Histopathol 2014; 2(4.000: 217-223

  2. 75 FR 69165 - Conductor Certification

    Science.gov (United States)

    2010-11-10

    ... From the Federal Register Online via the Government Publishing Office ] Part II Department of Transportation Federal Railroad Administration 49 CFR Part 242 Conductor Certification; Proposed Rule #0;#0;Federal Register / Vol. 75, No. 217 / Wednesday, November 10, 2010 / Proposed Rules#0;#0; ] DEPARTMENT...

  3. Experimental Method of Generating Electromagnetic Gaussian Schell-model Beams

    Science.gov (United States)

    2015-03-26

    3.15) must be computed. Making use of common trigonometric identities and Euler’s formula, additional simplifications can be made to the resultant...9 Parameters Aα, Bαβ, σα, and δαβ in Eq. (2.17) are independent of position but depend on frequency, and I is the identity matrix. The above

  4. Codependency: Clarifying the Construct.

    Science.gov (United States)

    Springer, Carrie A.; Britt, Thomas W.; Schlenker, Barry R.

    1998-01-01

    College students (N=217) completed questionnaires to examine associations between codependency, relationship quality, and personality characteristics. Codependency was associated with lower self-esteem and lower perception of interpersonal control. Codependency was also found to be associated with greater self-consciousness, social anxiety, and…

  5. Annual Report of the Chief of Engineers, U.S. Army, on Civil Works Activities 1959

    Science.gov (United States)

    1959-01-01

    1, 460 Mount Vernon , Ind__ ---- ------------------- -4, 699, 217 Bodega Bay, Calif--------------- ---------------------------- 2, 050 Crescent City...Jones River, Del Smyrna River, Del.2- - - - Back Creek (Anne Arundel County, Md.) ... Broad Creek, Somerset County, Md Broadwater Creek, Md Cadle Creek...Md___ Neale Sound, Md__ Northeast River, Md__ Parish Creek, Md__ Patuxent River, Md_ Pocomoke River, Md_ Rhodes Point to Tylerton, Somerset County

  6. Planck early results. XVIII. The power spectrum of cosmic infrared background anisotropies

    DEFF Research Database (Denmark)

    Bucher, M.; Delabrouille, J.; Giraud-Héraud, Y.

    2011-01-01

    Using Planck maps of six regions of low Galactic dust emission with a total area of about 140 deg2, we determine the angular power spectra of cosmic infrared background (CIB) anisotropies from multipole = 200 to = 2000 at 217, 353, 545 and 857 GHz. We use 21-cm observations of Hi as a tracer of t...

  7. Planck early results. XIII. Statistical properties of extragalactic radio sources in the Planck Early Release Compact Source Catalogue

    DEFF Research Database (Denmark)

    Bucher, M.; Delabrouille, J.; Giraud-Héraud, Y.

    2011-01-01

    The data reported in Planck's Early Release Compact Source Catalogue (ERCSC) are exploited to measure the number counts (dN/dS) of extragalactic radio sources at 30, 44, 70, 100, 143 and 217 GHz. Due to the full-sky nature of the catalogue, this measurement extends to the rarest and brightest sou...

  8. The Relationships among Unethical Computer Usage Behavior and Some Personality Characteristics of Turkish University Students

    Science.gov (United States)

    Ceyhan, A. Aykut; Ceyhan, Esra

    2007-01-01

    This research aims at examining the relationships among unethical computer usage behavior and the personality characteristics of locus of control, adjustment to social norms, antisocial tendency, and aggression on Turkish university students. The research was applied to 217 university students. Data were collected through Unethical Computer Using…

  9. Comparison of chloroquine with artesunate in the treatment of cerebral malaria in Ghanaian children

    DEFF Research Database (Denmark)

    Goka, B Q; Adabayeri, V; Ofori-Adjei, E;

    2001-01-01

    and neurological deficits were documented. There was no difference in mortality rates (chloroquine, 16.7 per cent; artesunate, 21.7 per cent; p = 0.6), neurological deficit at day 14 (chloroquine, 0 per cent; artesunate, 4.3 per cent; p = 0.3), resolution of fever (p = 0.55), and coma recovery time (p = 0...

  10. Crosslinking with transglutaminase does not change metabolic effects of sodium caseinate in model beverage in healthy young individuals

    National Research Council Canada - National Science Library

    Juvonen, Kristiina R; Lille, Martina E; Laaksonen, David E; Mykkänen, Hannu M; Niskanen, Leo K; Herzig, Karl-Heinz; Poutanen, Kaisa S; Karhunen, Leila J

    2012-01-01

    .... Whey protein was included as reference protein. Thirteen healthy individuals (23.3 ± 1.1 y, BMI 21.7 ± 0.4 kg/m2) participated in a single-blind crossover design experiment in which the subjects consumed three different isovolumic...

  11. Dicty_cDB: AFJ360 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available none) Artemia franciscana cathepsin L pr... 217 8e-55 AY336798_1( AY336798 |pid:none) Rhipicephalus haemaphysalo...ides hae... 214 1e-54 AY336797_1( AY336797 |pid:none) Rhipicephalus haemaphysaloides hae... 213 1e-54 pr

  12. Compilation of Fall 1974 Goals, Subgoals and Priorities Meeting Goals Collection Criteria.

    Science.gov (United States)

    Systems Planning Corp., Sacramento, CA.

    California school districts reported their goals, subgoals, and priorities by matching statements to those in a catalog of 279 possible educational goals developed by a state legislature subcommittee. This report compiles data collected from 217 school districts that met certain goals collection criteria. Data from the remaining 614 participating…

  13. EST Table: FS743436 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS743436 E_FL_bmmt_25K22_R_0 10/09/28 99 %/217 aa ref|NP_001040134.1| isocitrate de...3304|DanaGF10112-PA 10/08/28 78 %/215 aa F59B8.2#CE03436#WBGene00010317#locus:idh-1#isocitrate dehydrogenase

  14. Thermodynamics around the first-order ferromagnetic phase transition of Fe2P single crystals

    NARCIS (Netherlands)

    Hudl, M.; Campanini, D.; Caron, L.; Höglin, V.; Sahlberg, M.; Nordblad, P.; Rydh, A.

    2014-01-01

    The specific heat and thermodynamics of Fe2P single crystals around the first-order paramagnetic to ferromagnetic (FM) phase transition at TC≃217K are empirically investigated. The magnitude and direction of the magnetic field relative to the crystal axes govern the derived H−T phase diagram. Striki

  15. AcEST: DK951397 [AcEST

    Lifescience Database Archive (English)

    Full Text Available aracterized protein YNL018C OS=Saccharo... 33 1.9 sp|Q11EU7|METE_MESSB 5-methyltetrahydropteroyltriglutamate... Sbjct: 217 PPHSPHI 223 >sp|Q11EU7|METE_MESSB 5-methyltetrahydropteroyltriglutama

  16. Vaccine Risk/Benefit Communication: Effect of an Educational Package for Public Health Nurses

    Science.gov (United States)

    Davis, Terry C.; Fredrickson, Doren D.; Kennen, Estela M.; Humiston, Sharon G.; Arnold, Connie L.; Quinlin, Mackey S.; Bocchini, Joseph A., Jr.

    2006-01-01

    The purpose of this study was to determine whether an in-service for public health nurses (PHNs) and accompanying educational materials could improve vaccine risk/benefit communication. The content and timing of vaccine communication were recorded during 246 pre-and 217 post-intervention visits in two public health immunization clinics.…

  17. Planck early results. IV. First assessment of the High Frequency Instrument in-flight performance

    DEFF Research Database (Denmark)

    Bréelle, E.; Bucher, M.; Cressiot, C.;

    2011-01-01

    The Planck High Frequency Instrument (HFI) is designed to measure the temperature and polarization anisotropies of the cosmic microwave background and Galactic foregrounds in six ~30% bands centered at 100, 143, 217, 353, 545, and 857 GHz at an angular resolution of 10′ (100 GHz), 7′ (143 GHz), a...

  18. Analysis of natural isolates of Lactobacilli resistant to bacteriocin nisin

    Directory of Open Access Journals (Sweden)

    Strahinić Ivana D.

    2005-01-01

    Full Text Available The collection of lactic acid bacteria (LAB was made by isolation of microorganisms from fermented products traditionally manufactured in different geographical regions (high mountains, river valleys, seaside, etc. Among collected LAB, 51 isolates were identified as Lactobacillus sp. Results showed that all isolated lactobacilli were mesophilic strains, since they grew at 15°C and 30°C but not at 45°C. Testing the ability of isolated lactobacilli to grow in the presence of nisin revealed that Lactobacillus sp. isolates designed BGCGK4, BGHN40, BGBUK2-8, BGBUK2-7 and BGBUK2-16 were resistant to nisin. Determination of the minimal inhibitory concentrations (MIC for nisin revealed that the most resistant isolate was Lactobacillus sp. BGCGK4. Isolate BGBUK2-16, determined as Lactobacillus paracasei subsp. paracasei, produces bacteriocin, named Bac217 and showed a resistance to 8000 IU/ml of nisin. Plasmid curing of BGBUK2-16 resulted in derivatives BGBUK2-16/K2 and BGBUK2-16/K4. Derivative BGBUK2-16/K2 retained resistance to Bac217 and nisin, but lost the ability to synthesise Bac217. Derivative BGBUK2-16/K4 lost concomitantly the resistance to both Bac217 and nisin.

  19. AcEST: BP912285 [AcEST

    Lifescience Database Archive (English)

    Full Text Available utative uncharacterized protein YHR217C OS... 31 4.6 sp|P08411|POLN_SFV Non-structural polyprotein OS=Semliki forest...ural polyprotein OS=Semliki forest virus PE=1 SV=2 Length = 2432 Score = 30.0 bits (66), Expect = 7.9 Identi

  20. Development of a ROTC/Army Career Commitment Model. Volume 1

    Science.gov (United States)

    1975-11-01

    respect to demographic differences, a greater proportion of cadets come from military familias and from families that moved around 3 lot vhile the student...Sophomore Perceived Loss of Persona • Control and Individuality .27 .05 Willingness to join ROTC without fin ncial benefits (Item IV-U)g 2.17 2.54 Note

  1. Shyness and Love on a College Campus.

    Science.gov (United States)

    Maroldo, Georgette K.

    1982-01-01

    Shyness and love scales were administered to 153 men and 217 women at Texas Lutheran College. Love, dating, and friendship groups were identified on the love scale with respect, congeniality, altruism, physical attraction, and attachment subscales. For the love and friendship groups, shyness appears to be a barrier. (Author/CM)

  2. Unmanned Aircraft Pilot Medical Certification Requirements

    Science.gov (United States)

    2007-02-01

    Warren Silberman represented the FAA Aerospace Medical Certification Division in regard to the medical certification require- ments. Given that the...Johnson, Marca Access 5 marca@direcway.com 410-961-3149 McCarley, Jason U of Illinois Institute of Aviation mccarley@uiuc.edu 217-244-8854 Silberman

  3. NEW PROTEIN FEEDS AND STRATEGIES FOR FUTURE ANIF,IAL ...

    African Journals Online (AJOL)

    Verification for more intensive animal production prac- tices in future thus ... million l), mutton 84 000 tons (49 per cent) and beef. 217 000 tons ... New protein sources for animal production. Fir tu re by-p ro ... nure (f{yman, 1978), (3) the effect of molds or fungi cornmon in .... nicify, mutagenicity, toxicity (mycotoxins and l'reavy.

  4. 76 FR 33764 - Announcement of Meeting of the Secretary's Advisory Committee on National Health Promotion and...

    Science.gov (United States)

    2011-06-09

    ... Health Promotion. ACTION: Notice of Meeting. Authority: 42 U.S.C. 217a, Section 222 of the Public Health... committee meeting regarding the national health promotion and disease prevention objectives for 2020. This... Committee on National Health Promotion and Disease Prevention Objectives for 2020 will address efforts...

  5. 76 FR 16777 - Announcement of Meeting of the Secretary's Advisory Committee on National Health Promotion and...

    Science.gov (United States)

    2011-03-25

    ... Health Promotion. ACTION: Notice of meeting. Authority: 42 U.S.C. 217a, Section 222 of the Public Health... meeting regarding the national health promotion and disease prevention objectives for 2020. This meeting... Committee on National Health Promotion and Disease Prevention Objectives for 2020 (Committee) will...

  6. Water Reclamation and Reuse.

    Science.gov (United States)

    Smith, Daniel W.

    1978-01-01

    Presents a literature review of water reclamation and reuse. This review covers: (1) water resources planning; (2) agriculture and irrigation; (3) ground recharge; (4) industrial reuse; (5) health considerations; and (6) technology developments. A list of 217 references is also presented. (HM)

  7. 77 FR 41481 - Integration of Variable Energy Resources

    Science.gov (United States)

    2012-07-13

    ... the purpose of power production forecasting. DATES: Effective Date: This rule will become effective... Energy Policy and Innovation, Federal Energy Regulatory Commission, 888 First Street NE., Washington, DC... Forecasting 1. Data Requirements 155 2. Definition of VER 200 3. Data Sharing 217 4. Cost Recovery 222...

  8. Radiation damage of laser materials. Citations from the NTIS data base

    Science.gov (United States)

    Carrigan, B.

    1980-05-01

    Laser beam damage to laser materials such as optical glass, glass fibers, alkali metal halides, metals, mirrors, optical coatings, dielectrics, semiconductors, and matrix materials is studied. The majority of these citations concern infrared laser damage to infrared optical materials. This updated bibliography contains 217 abstracts, 10 of which are new entries to the previous edition.

  9. Synthesis and Physicochemical Properties of [19,20-13C]-17α-Ethinylestradiol

    NARCIS (Netherlands)

    Kraan, G.P.B.; Drayer, N.M.; Kruizinga, W.H.; Vaalburg, W.; Hummelen, J.C.

    1989-01-01

    13C2-17α-ethinylestradiol (13C2-EE2) was synthesized from estrone and 13C2-C2H2-gas to measure the metabolic clearance rate and the plasma concentration of 17α-ethinylestradiol (EE2) in tall girls, who are treated with high dosages of this estrogen. Interesting characteristics determined by (i) MS:

  10. Living Together: The Impact of the Intifada and the Peace Negotiations on Attitudes toward Coexistence of Arab and Jewish Pupils in Ethnically Segregated and Mixed Schools in Jaffa.

    Science.gov (United States)

    Zuzovsky, Ruth

    1997-01-01

    Changes in the willingness of Jews and Arabs to coexist were studied in 1989 with 217 12-year-olds and in 1994 with 194 in Jaffa (Israel), where both Jews and Arabs live. Separatist attitudes increased and faith in coexistence decreased, but mixed schools seemed to improve attitudes toward coexistence. (SLD)

  11. El papel de la Inteligencia Emocional en la resolución de problemas sociales en estudiantes adolescentes = The role of Emotional Intelligence in solving social problems in a sample of adolescent’s students

    OpenAIRE

    Pena Garrido, Mario; Extremera Pacheco, Natalio; Rey Peña, Lourdes

    2011-01-01

    La presente investigación, con una muestra de 217 adolescentes, se centra en el análisis de la relación entre la inteligencia emocional percibida (IEP) y el grado en que el estudiante afronta y soluciona problemas sociales. Los resultados evidenciaron

  12. Planck 2013 results. XXX. Cosmic infrared background measurements and implications for star formation

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.

    2014-01-01

    We present new measurements of cosmic infrared background (CIB) anisotropies using Planck. Combining HFI data with IRAS, the angular auto-and cross-frequency power spectrum is measured from 143 to 3000 GHz, and the auto-bispectrum from 217 to 545 GHz. The total areas used to compute the CIB power...

  13. Factors associated with osteoporosis among older patients at the ...

    African Journals Online (AJOL)

    TO Alonge

    Results: The point prevalence of osteoporosis was 56.9% (males = 43.7% and females = 65.8%). The most significant ..... obesity a BMI ≥ 30.0 kg/m2.17 The average distance walked by the ... The level of significance was set at p ≤ 0.05.

  14. Downward Spirals, Boiled Frogs, and Catastrophes: Examining the Rate of School Decline

    Science.gov (United States)

    Hochbein, Craig

    2012-01-01

    The purpose of this study is to determine the validity of common assumptions about the rate at which school decline manifests. From a population of 981 elementary schools in the state of Virginia, the author uses three operational definitions of school decline to identify samples of declining schools: Absolute (n = 217), Relational (n = 510), and…

  15. Exercising with Passion: Initial Validation of the Passion Scale in Exercise

    Science.gov (United States)

    Parastatidou, Irini S.; Doganis, Georgios; Theodorakis, Yannis; Vlachopoulos, Symeon P.

    2012-01-01

    The purpose of the researchers in the study was to psychometrically evaluate Passion Scale scores (Vallerand et al., 2003) in exercise. Self-report data were collected from two samples of Greek exercise participants. Sample 1 (n = 217) provided data on the Passion Scale and the self-determination theory variables of perceived autonomy support by…

  16. A Systematic Review of Psychosocial Interventions for Adults with Autism Spectrum Disorders

    Science.gov (United States)

    Bishop-Fitzpatrick, Lauren; Minshew, Nancy J.; Eack, Shaun M.

    2013-01-01

    Individuals with autism spectrum disorders (ASD) spend the majority of their lives as adults, and psychosocial interventions show promise for improving outcomes in this population. This research conducted a systematic review of all peer-review studies evaluating psychosocial interventions for adults with ASD. A total of 1,217 studies were…

  17. Some engineering properties of white kidney beans (Phaseolus ...

    African Journals Online (AJOL)

    ajl yemi

    2011-12-19

    Dec 19, 2011 ... average, the bean contains 21.7 g protein, 0.75 g oil, 55.2 g total carbohydrates ..... some physico-chemical properties of Turkey okra (Hibiscus esculenta. L.) seeds. ... major commercial Turkish hazelnut varieties. J. Food Eng.

  18. Examining the Clinical Correlates of Autism Spectrum Disorder in Youth by Ascertainment Source

    Science.gov (United States)

    Joshi, Gagan; Faraone, Stephen V.; Wozniak, Janet; Petty, Carter; Fried, Ronna; Galdo, Maribel; Furtak, Stephannie L.; McDermott, Katie; Epstien, Cecily; Walker, Rosemary; Caron, Ashley; Feinberg, Leah; Biederman, Joseph

    2014-01-01

    To examine whether presentation of autism spectrum disorder (ASD) and associated patterns of psychiatric comorbidity and dysfunction vary by referral source. ASD youth referred to a specialized ambulatory program for ASD (N = 143) were compared to ASD youth referred to a general child psychiatry clinic (N = 217). More ASD clinic youth met criteria…

  19. Komplikationer til langtidsbehandling med vitamin K-antagonister

    DEFF Research Database (Denmark)

    May, O; Garne, E; Mickley, H

    1990-01-01

    Long-term treatment with vitamin K antagonists (vKA) frequently involves complications. The commonest complication is haemorrhage and cases of serious haemorrhage are stated in the literature to occur with a frequency per 1,000 treatment years of 12-108, of which 2-17 are fatal. The majority...

  20. Adaptive Profiles in Autism and Other Neurodevelopmental Disorders

    Science.gov (United States)

    Mouga, Susana; Almeida, Joana; Café, Cátia; Duque, Frederico; Oliveira, Guiomar

    2015-01-01

    We investigated the influence of specific autism spectrum disorder (ASD) deficits in learning adaptive behaviour, besides intelligence quotient (IQ). Participated 217 school-aged: ASD (N = 115), and other neurodevelopmental disorders (OND) groups (N = 102) matched by Full-Scale IQ. We compared standard scores of Vineland Adaptive Behaviour Scale…

  1. Establishing the potential dependent equilibrium oxide coverage on platinum in alkaline solution and its influence on the oxygen reduction

    DEFF Research Database (Denmark)

    Wiberg, Gustav; Arenz, Matthias

    2012-01-01

    Publication year: 2012 Source:Journal of Power Sources, Volume 217 Gustav K.H. Wiberg, Matthias Arenz The oxidation process of polycrystalline platinum subjected to alkaline solution is re-examined using a combination of cyclic voltammetry and potential hold techniques in Ar, H2 and O2 purged 0.1 M...

  2. Psychological Impact of a Nuclear Power Plant: Changing Perceptions of Community and Neighborhood.

    Science.gov (United States)

    Hughey, Joseph B.

    1986-01-01

    Examines change in attitude toward community and descriptions of neighborhood environments of 217 residents of rural host community for a nuclear power plant. Finds negative attitude change and less positive descriptions of neighborhoods. Discusses implications for community psychology and preventive intervention. (LFL)

  3. Hopelessness and Suicidal Behavior among Chinese, Thai and Korean College Students and Predictive Effects of the World Health Organization's WHOQOL-BREF

    Science.gov (United States)

    Kay, Noy; Li, Kaigang; Xiao, Xia; Nokkaew, Nattiporn; Park, Bock-Hee

    2009-01-01

    The purpose of this study was to assess the current status of suicide behavior and to examine the association between hopeless feelings, suicidal behavior and components of the WHO Quality-of-Life-BREF instrument among college students (n = 1,217) in China, Thailand, and Korea. Results showed 3.7% Thai, 10% Chinese, and 13.2% Korean students…

  4. A highly sensitive spin-valve transistor

    NARCIS (Netherlands)

    Erve, van 't O.M.J.; Vlutters, R.; Anil Kumar, P.S.; Kim, S.D.; Jansen, R.; Lodder, J.C.; Hadjipanayis, G.C.

    2001-01-01

    In this paper we present a spin-valve transistor made with a silicon on insulator wafer as emitter and a double sided polished Si wafer as collector. Using vacuum metal bonding we obtain a three terminal device in which a spin-valve layer is sandwiched between two Si wafers. We measure a 217% change

  5. Ocean and Coastal Modeling: Nonlinear Acoustic Propagation

    Science.gov (United States)

    2009-03-27

    ASW, SPECOPS and MIW, enabling superior analysis of environmental variability to support tactical decision planning. Ultimately, smart climatology...Conference on Mathematics and Continuum Mechanics. ISBN: 978-989-95011-2-6, Centra Internacional de Matematica (CIM), 207-217, Porto- Portugal

  6. Storytelling Slide Shows to Improve Diabetes and High Blood Pressure Knowledge and Self-Efficacy: Three-Year Results among Community Dwelling Older African Americans

    Science.gov (United States)

    Bertera, Elizabeth M.

    2014-01-01

    This study combined the African American tradition of oral storytelling with the Hispanic medium of "Fotonovelas." A staggered pretest posttest control group design was used to evaluate four Storytelling Slide Shows on health that featured community members. A total of 212 participants were recruited for the intervention and 217 for the…

  7. Comparative Studies of White and Red Allium cepa Cultivated in ...

    African Journals Online (AJOL)

    MBI

    2015-09-09

    Sep 9, 2015 ... red Allium cepa contained 89.62 + 0.83 and 88.48 + 0.03% moisture, 3.33 + 0.56 and 3.17 + 0.29% ash, 2.17 +. 0.29 and ... oxidative stress, caused by free radicals that ... cancer, diabetes, obesity, arthritis and diseases of.

  8. AcEST: DK951868 [AcEST

    Lifescience Database Archive (English)

    Full Text Available -30 tr|Q43412|Q43412_BIDPI Calmodulin OS=Bidens pilosa PE=2 SV=1 133 5e-30 tr|A9NPT3|A9NPT3_PICSI Putative u...EKLTDEEVDEMIREADVDGDGQINYEEFV 143 Query: 217 SVMV 228 VM+ Sbjct: 144 KVMM 147 >tr|Q43412|Q43412_BIDPI Calmodulin OS=Bidens

  9. Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

    DEFF Research Database (Denmark)

    Taylor, Jenny C; Martin, Hilary C; Lise, Stefano

    2015-01-01

    To assess factors influencing the success of whole-genome sequencing for mainstream clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families across a broad spectrum of disorders in whom previous screening had identified no pathogenic variants. We quantified the numb...

  10. Diagnostico prenatal citogenetico mediante amniocentesis durante los trimestres II y III de gestacion en Costa Rica

    National Research Council Canada - National Science Library

    Castro Volio, Isabel; Mangel, Kay Sander; Vargas Prado, Manuel; Sanchez Chaves, Luis; Escalante Lopez, Gerardo

    2001-01-01

    ... % en el III trimestre. Se utilizo el sistema cerrado de histocultivo y la cosecha por suspension. El resaltado final se obtuvo en 14 dias (mediana). De las 842 muestras de liquido amniotico, en 217 no fue posible obtener resultados. Los 625 cariotipos fetales fueron anormales en 55 casos (9 %): 33 cariotipos trisomicos (incluyendo una trisomia 13 por translo...

  11. 47 CFR 15.215 - Additional provisions to the general radiated emission limitations.

    Science.gov (United States)

    2010-10-01

    ... RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.215 Additional provisions to the general radiated emission limitations. (a) The regulations in §§ 15.217 through... frequency bands shown in these alternative provisions must be attenuated to the emission limits shown...

  12. Projecting Continuing Student Enrolments: A Comparison of Approaches

    Science.gov (United States)

    Aitken, Robert; Young, Anne; McConkey, Kevin

    2011-01-01

    Higher education in Australia is undergoing a comprehensive reform with particular focus on higher levels of attainment by increasing access to university study for Australians from all backgrounds. To support the government's ambition of around 217,000 additional graduates by 2025, it has committed to removing caps and funding student places on…

  13. 77 FR 68567 - Announcement of Funding Awards for the Continuum of Care Program for Fiscal Year (FY) 2011

    Science.gov (United States)

    2012-11-15

    ... Continuum of Care...... AR 31,824 Economic and Nonprofit Solutions, Inc AR 50,000 Hot Spring County AR 206... Asian Pacific Women's Center......... CA 149,813 Aspiranet CA 94,959 AspiraNet CA 140,000 Berkeley Food and Housing Project.... CA 253,627 Berkeley Food and Housing Project.... CA 242,217 Berkeley Food and...

  14. Browse Title Index

    African Journals Online (AJOL)

    Items 151 - 200 of 217 ... M Ngeno, PB Ooko, S Seno, M Oloo, HM Topazian, RE White ... Score predicts postoperative complications in traumatic brain injury, Abstract PDF ... Vol 9, No 2 (2012), The Impact Of Dental Auxiliaries In Oral Health ...

  15. Cellular Consequences of Telomere Shortening in Histologically Normal Breast Tissues

    Science.gov (United States)

    2011-09-01

    mechanism. Cytogenet Genome Res 2008, 122:281–291 12. Cesare AJ, Reddel RR: Alternative lengthening of telomeres: models, mechanisms and implications......astrocytomas. Clin. Cancer Res. 11, 217 (2005). Medline 21. M. A. Cerone, C. Autexier, J. A. Londoño- Vallejo , S. Bacchetti, A human cell line that maintains

  16. Construct Validation of a Measure to Assess Sustainability of School-Wide Behavior Interventions

    Science.gov (United States)

    Hume, Amanda; McIntosh, Kent

    2013-01-01

    This study assessed aspects of construct validity of the School-wide Universal Behavior Sustainability Index-School Teams (SUBSIST), a measure evaluating critical features of the school context related to sustainability of school-wide interventions. Participants at 217 schools implementing School-wide Positive Behavior Support (SWPBS) were…

  17. Spreading Depolarizations of Cerebral Cortex After Brain Injury: Mechanism of Injury Progression and Relevance to Military Neurotrauma

    Science.gov (United States)

    2006-11-01

    withdrawal of the strip by gentle traction (Fig. 1; Strong et al., 2002). Insofar as possible, the strip was placed along a single gyrus radiating...insulin was given sub- cutaneously beginning 71 hr post-injury when glucose reached 212 mg/dL. PO2 was 217-273 mmHg through 47 hr post- injury, 92-148

  18. FORMULASI DAN STABILITAS MIKROEMULSI O/W DENGAN METODE EMULSIFIKASI SPONTAN MENGGUNAKAN VCO DAN MINYAK SAWIT SEBAGAI FASE MINYAK: PENGARUH RASIO SURFAKTAN-MINYAK

    Directory of Open Access Journals (Sweden)

    Setyaningrum Ariviani

    2015-05-01

    Mikroemulsi tersebut memiliki distribusi ukuran partikel monomodal, rerata diameter partikel dan viskositas mencapai 21,7 ± 0,02nm dan 6,0 ± 0,10cp (VCO, 22,9 ± 0,15nm dan 6,2 ± 0,05cp (minyak sawit. Kata kunci: Mikroemulsi, formulasi, stabilitas, surfaktan minyak

  19. Cabazitaxel:a new drug for metastatic prostate cancer

    Institute of Scientific and Technical Information of China (English)

    Marijo Bilusic; William L Dahut

    2011-01-01

    @@ In Western countries, prostate cancer is the most common malignancy in men and ranks third in mortality.In 2010, an esti-mated 217 730 new cases are anticipated in the United States, and about 32 050 men are expected to die from the disease.

  20. Feelings of Well-Being Before and After an Abortion.

    Science.gov (United States)

    Hittner, Amy

    1987-01-01

    Examined feelings of well-being in 217 women who had abortions. Results suggest that, compared to women who have not had abortions, those who choose abortion feel more negatively. Of women choosing abortion, those who are already mothers are most likely to be depressed and lonely, followed by those from lower educational and socioeconomic…