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Sample records for actinium 215

  1. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  2. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  3. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  4. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Science.gov (United States)

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development.

  5. Relativistic small-core pseudopotentials for actinium, thorium, and protactinium.

    Science.gov (United States)

    Weigand, Anna; Cao, Xiaoyan; Hangele, Tim; Dolg, Michael

    2014-04-03

    Small-core pseudopotentials for actinium, thorium, and protactinium have been energy-adjusted to multiconfiguration Dirac-Hartree-Fock reference data based on the Dirac-Coulomb-Breit Hamiltonian and the Fermi nucleus model. Corresponding optimized valence basis sets of polarized valence quadruple-ζ quality are presented. Atomic test calculations for the first four ionization potentials show satisfactory results at both the Hartree-Fock and the multireference averaged coupled-pair functional level. Highly correlated Fock-space coupled cluster calculations demonstrate that the new pseudopotentials yield ionization potentials, which are in excellent agreement with corresponding all-electron results and experimental data. The pseudopotentials and basis sets supplement a similar set previously published for uranium.

  6. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  7. Comment: 215 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available 215.png Taxonomy icon (c) Database Center for Life Science licensed under CC Attribution2.1 Japan アイコン:電子顕微鏡バージョン bando 2010/02/15 15:30:03 2010/02/15 15:30:03 ...

  8. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  9. Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

    Science.gov (United States)

    Radchenko, V; Engle, J W; Wilson, J J; Maassen, J R; Nortier, F M; Taylor, W A; Birnbaum, E R; Hudston, L A; John, K D; Fassbender, M E

    2015-02-06

    Actinium-225 (t1/2=9.92d) is an α-emitting radionuclide with nuclear properties well-suited for use in targeted alpha therapy (TAT), a powerful treatment method for malignant tumors. Actinium-225 can also be utilized as a generator for (213)Bi (t1/2 45.6 min), which is another valuable candidate for TAT. Actinium-225 can be produced via proton irradiation of thorium metal; however, long-lived (227)Ac (t1/2=21.8a, 99% β(-), 1% α) is co-produced during this process and will impact the quality of the final product. Thus, accurate assays are needed to determine the (225)Ac/(227)Ac ratio, which is dependent on beam energy, irradiation time and target design. Accurate actinium assays, in turn, require efficient separation of actinium isotopes from both the Th matrix and highly radioactive activation by-products, especially radiolanthanides formed from proton-induced fission. In this study, we introduce a novel, selective chromatographic technique for the recovery and purification of actinium isotopes from irradiated Th matrices. A two-step sequence of cation exchange and extraction chromatography was implemented. Radiolanthanides were quantitatively removed from Ac, and no non-Ac radionuclidic impurities were detected in the final Ac fraction. An (225)Ac spike added prior to separation was recovered at ≥ 98%, and Ac decontamination from Th was found to be ≥ 10(6). The purified actinium fraction allowed for highly accurate (227)Ac determination at analytical scales, i.e., at (227)Ac activities of 1-100 kBq (27 nCi to 2.7 μCi).

  10. 48 CFR 215.404 - Proposal analysis.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Proposal analysis. 215.404 Section 215.404 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... Proposal analysis....

  11. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  12. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Energy Technology Data Exchange (ETDEWEB)

    Raeder, S., E-mail: s.raeder@gsi.de [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Bastin, B. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Block, M. [Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Institut für Kernchemie, Johannes Gutenberg Universität, 55128 Mainz (Germany); Creemers, P. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Ferrer, R. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fléchard, X. [LPC Caen, ENSICAEN, Université de Caen, CNRS/IN2P3, Caen (France); Franchoo, S. [Institute de Physique Nucléaire (IPN) d’Orsay, 91406 Orsay, Cedex (France); Ghys, L. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); SCK-CEN, Belgian Nuclear Research Center, Boeretang 200, 2400 Mol (Belgium); Gaffney, L.P.; Granados, C. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Heinke, R. [Institut für Physik, Johannes Gutenberg Universität, 55128 Mainz (Germany); Hijazi, L. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); and others

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  13. 25 CFR 215.12 - Advertising costs.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Advertising costs. 215.12 Section 215.12 Indians BUREAU... LEASES, QUAPAW AGENCY § 215.12 Advertising costs. All advertising costs, publication fees, expenses incurred for abstracts of lease title, and other expenses incurred in connection with the advertising...

  14. 48 CFR 215.402 - Pricing policy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pricing policy. 215.402... OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 215.402 Pricing policy. Follow the procedures at PGI 215.402 when conducting cost or price analysis,...

  15. 32 CFR 215.6 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 215.6 Section 215.6 National... EMPLOYMENT OF MILITARY RESOURCES IN THE EVENT OF CIVIL DISTURBANCES § 215.6 Responsibilities. (a) The... the accomplishment of his public affairs responsibilities set forth in paragraph (f) of this...

  16. 36 CFR 2.15 - Pets.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Pets. 2.15 Section 2.15 Parks... USE AND RECREATION § 2.15 Pets. (a) The following are prohibited: (1) Possessing a pet in a public... area closed to the possession of pets by the superintendent. This subparagraph shall not apply to...

  17. 48 CFR 215.270 - Peer Reviews.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Peer Reviews. 215.270 Section 215.270 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT... of Proposals and Information 215.270 Peer Reviews. Agency officials shall conduct Peer Reviews...

  18. 46 CFR 108.215 - Insect screens.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Insect screens. 108.215 Section 108.215 Shipping COAST... Construction and Arrangement Accommodation Spaces § 108.215 Insect screens. (a) Accommodation spaces must be protected against the admission of insects. (b) Insect screens must be installed when natural ventilation...

  19. 33 CFR 136.215 - Proof.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Proof. 136.215 Section 136.215 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION... SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.215 Proof. (a) In addition to...

  20. 2 CFR 215.43 - Competition.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Competition. 215.43 Section 215.43 Grants... ORGANIZATIONS (OMB CIRCULAR A-110) Post Award Requirements Procurement Standards § 215.43 Competition. All... free competition. The recipient shall be alert to organizational conflicts of interest as well...

  1. 32 CFR 215.10 - Funding.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Funding. 215.10 Section 215.10 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS EMPLOYMENT OF MILITARY RESOURCES IN THE EVENT OF CIVIL DISTURBANCES § 215.10 Funding. (a) Reporting requirements...

  2. 14 CFR 120.215 - Covered employees.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Covered employees. 120.215 Section 120.215... Alcohol Testing Program Requirements § 120.215 Covered employees. (a) Each employee, including any... accordance with this subpart. This includes full-time, part-time, temporary, and intermittent...

  3. 49 CFR 238.215 - Rollover strength.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Rollover strength. 238.215 Section 238.215 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.215 Rollover strength. (a) Each passenger car shall be designed to rest on its side and...

  4. 49 CFR 21.5 - Discrimination prohibited.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Discrimination prohibited. 21.5 Section 21.5... DEPARTMENT OF TRANSPORTATION-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 21.5 Discrimination... discrimination under, any program to which this part applies. (b) Specific discriminatory actions prohibited:...

  5. 6 CFR 21.5 - Discrimination prohibited.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Discrimination prohibited. 21.5 Section 21.5... FROM THE DEPARTMENT OF HOMELAND SECURITY § 21.5 Discrimination prohibited. (a) General. No person in... participation in, be denied the benefits of, or be otherwise subjected to discrimination under, any program...

  6. 50 CFR 300.215 - Observers.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Observers. 300.215 Section 300.215... Western and Central Pacific Fisheries for Highly Migratory Species § 300.215 Observers. (a) Applicability... which a WCPFC Area Endorsement is required. (b) Notifications. (c) Accommodating observers. All...

  7. 47 CFR 80.215 - Transmitter power.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Transmitter power. 80.215 Section 80.215... MARITIME SERVICES General Technical Standards § 80.215 Transmitter power. (a) Transmitter power shown on the radio station authorization is the maximum power the licensee is authorized to use. Power...

  8. 2 CFR 215.36 - Intangible property.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Intangible property. 215.36 Section 215.36... NON-PROFIT ORGANIZATIONS (OMB CIRCULAR A-110) Post Award Requirements Property Standards § 215.36 Intangible property. (a) The recipient may copyright any work that is subject to copyright and was...

  9. 2 CFR 215.32 - Real property.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Real property. 215.32 Section 215.32 Grants... ORGANIZATIONS (OMB CIRCULAR A-110) Post Award Requirements Property Standards § 215.32 Real property. Each... real property acquired in whole or in part under awards. Unless otherwise provided by statute,...

  10. 7 CFR 215.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 215.3 Section 215.3 Agriculture... CHILD NUTRITION PROGRAMS SPECIAL MILK PROGRAM FOR CHILDREN § 215.3 Administration. (a) Within the Department, FNS shall act on behalf of the Department in the administration of the Program. Within FNS,...

  11. 25 CFR 215.5 - Royalty rates.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Royalty rates. 215.5 Section 215.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING OPERATIONS AND LEASES, QUAPAW AGENCY § 215.5 Royalty rates. (a) In leases offered for sale at public auction under the regulations in this part the royalty to be paid...

  12. 33 CFR 135.215 - Certification.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Certification. 135.215 Section... Financial Responsibility for Offshore Facilities § 135.215 Certification. (a) Applicants shall: (1) If the...) If any of the information submitted for certification is determined by the Fund Administrator to...

  13. 24 CFR 884.215 - Lease requirements.

    Science.gov (United States)

    2010-04-01

    ... which fall within the classifications listed below shall not be included in any Lease. (1) Confession of... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Lease requirements. 884.215 Section... RENTAL HOUSING PROJECTS Project Development and Operation § 884.215 Lease requirements. The Lease...

  14. 2 CFR 215.52 - Financial reporting.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Financial reporting. 215.52 Section 215.52... Financial reporting. (a) The following forms or such other forms as may be approved by OMB are authorized for obtaining financial information from recipients. (1) SF-269 or SF-269A, Financial Status...

  15. 42 CFR 93.215 - Investigation.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Investigation. 93.215 Section 93.215 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  16. 48 CFR 1852.215-84 - Ombudsman.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Ombudsman. 1852.215-84 Section 1852.215-84 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... selection process, or the adjudication of formal contract disputes. Therefore, before consulting with...

  17. 2 CFR 215.48 - Contract provisions.

    Science.gov (United States)

    2010-01-01

    ... violates or breaches the contract terms, and provide for such remedial actions as may be appropriate. (b... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Contract provisions. 215.48 Section 215.48... Contract provisions. The recipient shall include, in addition to provisions to define a sound and...

  18. 5 CFR 179.215 - Refunds.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Refunds. 179.215 Section 179.215 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS... (unless expressly prohibited by statute or regulation); or (2) An administrative or judicial order...

  19. Dicty_cDB: SFC215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SF (Link to library) SFC215 (Link to dictyBase) - - - Contig-U16280-1 SFC215P (Link to Original site) SFC...215F 635 SFC215Z 734 SFC215P 1369 - - Show SFC215 Library SF (Link to library) Clone ID SFC...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SF/SFC2-A/SFC215Q.Seq.d/ Representative seq. ID SFC...215P (Link to Original site) Representative DNA sequence >SFC215 (SFC215Q) /CSM/SF/SFC2-A/SFC...xr*kgcqnqrth qlxk*fs Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SFC215 (SFC

  20. 49 CFR 215.101 - Scope.

    Science.gov (United States)

    2010-10-01

    ... TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components § 215.101 Scope. This subpart contains safety requirements prohibiting a railroad from placing or continuing in service a freight car that has certain defective components. Suspension System...

  1. 32 CFR 552.215 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... Demonstrations on the Installation of Aberdeen Proving Ground, Maryland § 552.215 Responsibilities. (a) Director, Law Enforcement and Security, U.S. Army Garrison, Aberdeen Proving Ground, will furnish police...

  2. 48 CFR 215.406-3 - Documenting the negotiation.

    Science.gov (United States)

    2010-10-01

    ... negotiation. 215.406-3 Section 215.406-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 215.406-3 Documenting the negotiation. Follow the procedures at PGI 215.406-3...

  3. Dicty_cDB: VSG215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VS (Link to library) VSG215 (Link to dictyBase) - - - Contig-U13538-1 VSG215P (Link to Original site) VSG...215F 213 VSG215Z 193 VSG215P 406 - - Show VSG215 Library VS (Link to library) Clone ID VSG... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VS/VSG2-A/VSG215Q.Seq.d/ Representative seq. ID VSG...215P (Link to Original site) Representative DNA sequence >VSG215 (VSG215Q) /CSM/VS/VSG2-A/VSG2...Q) /CSM/VS/VSH1-A/VSH112Q.Seq.d/ 355 3e-97 VSG523 (VSG523Q) /CSM/VS/VSG5-A/VSG523Q.Seq.d/ 355 3e-97 VSG304 (VSG304Q) /CSM/VS/VSG

  4. 49 CFR 215.105 - Defective axle.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.105 Defective axle. A railroad may not place or continue in service a car, if— (a) An axle on the car has a crack or is broken; (b) An axle on the car has a gouge in the surface that is— (1)...

  5. 49 CFR 215.103 - Defective wheel.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.103 Defective wheel. A railroad may not place or continue in service a car, if— (a) A wheel flange on the car is worn to a thickness of 7/8 of an inch, or less, at a point 3/8 of an inch above...

  6. 49 CFR 212.215 - Locomotive inspector.

    Science.gov (United States)

    2010-10-01

    ... applicable sections of the Safety Glazing Standards (49 CFR part 223), Locomotive Safety Standards (49 CFR part 229), Safety Appliance Standards (49 CFR part 231) and Power Brake Standards (49 CFR part 232), to... 49 Transportation 4 2010-10-01 2010-10-01 false Locomotive inspector. 212.215 Section...

  7. 7 CFR 215.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... CHILD NUTRITION PROGRAMS SPECIAL MILK PROGRAM FOR CHILDREN § 215.2 Definitions. For the purpose of this... the Child Nutrition Act of 1966. Adults means those persons not included under the definition of... the definition of School in this section. CND means the Child Nutrition Division of the Food...

  8. 47 CFR 215.1 - Background.

    Science.gov (United States)

    2010-10-01

    ... POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic pulse (EMP) is part of the complex environment produced by nuclear explosions. It consists of transient... among affected Federal agencies information concerning the telecommunications effects of EMP...

  9. 7 CFR 1160.215 - Assessment exemption.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order National Fluid Milk Processor Promotion Board § 1160.215 Assessment exemption. (a) No...

  10. 21 CFR 1311.215 - Internal audit trail.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Internal audit trail. 1311.215 Section 1311.215... ORDERS AND PRESCRIPTIONS (Eff. 6-1-10) Electronic Prescriptions § 1311.215 Internal audit trail. (a) The... with audit trail functions. (6) For application service providers, attempted or successful...

  11. 49 CFR 234.215 - Standby power system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Standby power system. 234.215 Section 234.215..., DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY AND STATE ACTION PLANS Maintenance, Inspection, and Testing Maintenance Standards § 234.215 Standby power system. A standby source of power...

  12. 25 CFR 215.24 - Books and accounts.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Books and accounts. 215.24 Section 215.24 Indians BUREAU... LEASES, QUAPAW AGENCY § 215.24 Books and accounts. (a) The lessee shall maintain books in which shall be... land. (b) An audit of the lessee's accounts and books shall be made semiannually, or at such...

  13. 20 CFR 655.215 - Territory of Guam.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Territory of Guam. 655.215 Section 655.215... Agricultural Employment § 655.215 Territory of Guam. Subpart C of this part does not apply to temporary employment in the Territory of Guam, and the Department of Labor does not certify to the United...

  14. 46 CFR 153.215 - Safety equipment lockers.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Safety equipment lockers. 153.215 Section 153.215... Vessel Requirements § 153.215 Safety equipment lockers. Each self-propelled ship must have the following: (a) Each tankship must have at least two safety equipment lockers. (b) One safety equipment...

  15. 45 CFR 150.215 - Extension for good cause.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Extension for good cause. 150.215 Section 150.215... Are Failing To Substantially Enforce HIPAA Requirements § 150.215 Extension for good cause. CMS may extend, for good cause, the time the State has for responding to the notice described in § 150.213...

  16. 49 CFR 215.121 - Defective car body.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Defective car body. 215.121 Section 215.121..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Car Bodies § 215.121 Defective car body. A railroad may not place or continue in service a car, if: (a) Any portion...

  17. 29 CFR 2.15 - Protection of witnesses.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Protection of witnesses. 2.15 Section 2.15 Labor Office of the Secretary of Labor GENERAL REGULATIONS Audiovisual Coverage of Administrative Hearings § 2.15 Protection of witnesses. A witness has the right, prior to or during his testimony, to exclude...

  18. 12 CFR 215.3 - Extension of credit.

    Science.gov (United States)

    2010-01-01

    ... participating bank, not by the originating bank. (f) Tangible economic benefit rule—(1) In general. An extension... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Extension of credit. 215.3 Section 215.3 Banks... OFFICERS, DIRECTORS, AND PRINCIPAL SHAREHOLDERS OF MEMBER BANKS (REGULATION O) § 215.3 Extension of...

  19. 48 CFR 253.215 - Contracting by negotiation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracting by negotiation. 253.215 Section 253.215 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.215 Contracting by negotiation....

  20. 48 CFR 2453.215 - Contracting by negotiation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracting by negotiation. 2453.215 Section 2453.215 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CLAUSES AND FORMS FORMS Prescription of Forms 2453.215 Contracting by negotiation....

  1. 48 CFR 53.215 - Contracting by negotiation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contracting by negotiation. 53.215 Section 53.215 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.215 Contracting by negotiation....

  2. 48 CFR 853.215 - Contracting by negotiation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting by negotiation. 853.215 Section 853.215 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CLAUSES AND FORMS FORMS Prescription of Forms 853.215 Contracting by negotiation....

  3. 41 CFR 101-6.215-3 - Supervision and coordination.

    Science.gov (United States)

    2010-07-01

    ... coordination. 101-6.215-3 Section 101-6.215-3 Public Contracts and Property Management Federal Property...-Nondiscrimination in Programs Receiving Federal Financial Assistance § 101-6.215-3 Supervision and coordination. The... provided in § 101-6.213), including the achievement of effective coordination and maximum uniformity...

  4. 12 CFR 215.8 - Records of member banks.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Records of member banks. 215.8 Section 215.8 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM LOANS TO EXECUTIVE OFFICERS, DIRECTORS, AND PRINCIPAL SHAREHOLDERS OF MEMBER BANKS (REGULATION O) § 215.8 Records...

  5. 10 CFR 1042.215 - Membership practices of certain organizations.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Membership practices of certain organizations. 1042.215 Section 1042.215 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 1042.215...

  6. 10 CFR 5.215 - Membership practices of certain organizations.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Membership practices of certain organizations. 5.215 Section 5.215 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 5.215 Membership practices...

  7. 23 CFR 668.215 - Programming and project procedures.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Programming and project procedures. 668.215 Section 668.215 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS EMERGENCY RELIEF PROGRAM Procedures for Federal Agencies for Federal Roads § 668.215...

  8. 25 CFR 215.7 - Advertisement of sale of leases.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Advertisement of sale of leases. 215.7 Section 215.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING OPERATIONS AND LEASES, QUAPAW AGENCY § 215.7 Advertisement of sale of leases. Upon authority being granted...

  9. 21 CFR 172.215 - Coumarone-indene resin.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Coumarone-indene resin. 172.215 Section 172.215... CONSUMPTION Coatings, Films and Related Substances § 172.215 Coumarone-indene resin. The food additive coumarone-indene resin may be safely used on grapefruit, lemons, limes, oranges, tangelos, and tangerines...

  10. 49 CFR 1542.215 - Law enforcement support.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Law enforcement support. 1542.215 Section 1542.215..., DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY AIRPORT SECURITY Operations § 1542.215 Law... program under § 1542.103(a) or (b) must provide: (1) Law enforcement personnel in the number and...

  11. 46 CFR 28.215 - Guards for exposed hazards.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Guards for exposed hazards. 28.215 Section 28.215 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY UNINSPECTED VESSELS REQUIREMENTS FOR COMMERCIAL....215 Guards for exposed hazards. (a) Each space on board a vessel must meet the requirements of...

  12. 42 CFR 403.215 - Loss ratio standards.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Loss ratio standards. 403.215 Section 403.215 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... of solicitation of individuals through the mail or by mass media advertising are...

  13. 49 CFR 215.119 - Defective freight car truck.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.119 Defective freight car truck. A railroad may not place or continue in service a... 49 Transportation 4 2010-10-01 2010-10-01 false Defective freight car truck. 215.119 Section...

  14. 32 CFR Appendix C to Part 45 - DD Form 215

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 215 C Appendix C to Part 45 National... CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to Part 45—DD Form 215 EC21OC91.050...

  15. 48 CFR 1652.215-71 - Investment Income.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Investment Income. 1652.215... 1652.215-71 Investment Income. As prescribed in 1615.470-1, the following clause shall be inserted in all FEHBP contracts based on cost analysis: Investment Income (JAN 1998) (a) The Carrier shall...

  16. 29 CFR 99.215 - Relation to other audit requirements.

    Science.gov (United States)

    2010-07-01

    ... audited as a major program using the risk-based audit approach described in § 99.520 and, if not, the... 29 Labor 1 2010-07-01 2010-07-01 true Relation to other audit requirements. 99.215 Section 99.215 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT...

  17. 42 CFR 57.215 - Records, reports, inspection, and audit.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Records, reports, inspection, and audit. 57.215... FOR CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS Health Professions Student Loans § 57.215 Records, reports, inspection, and audit. (a) Each...

  18. 48 CFR 452.215-72 - Amendments to Proposals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Amendments to Proposals. 452.215-72 Section 452.215-72 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CLAUSES... vertical lines adjacent to the change. The offeror shall include the date of the amendment on the...

  19. 14 CFR 21.5 - Airplane or Rotorcraft Flight Manual.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Airplane or Rotorcraft Flight Manual. 21.5... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.5 Airplane or Rotorcraft Flight Manual. (a) With each airplane or rotorcraft that was not type certificated with an Airplane or Rotorcraft Flight...

  20. 48 CFR 215.470 - Estimated data prices.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Estimated data prices. 215.470 Section 215.470 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM....470 Estimated data prices. (a) DoD requires estimates of the prices of data in order to evaluate...

  1. 44 CFR 19.215 - Membership practices of certain organizations.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Membership practices of certain organizations. 19.215 Section 19.215 Emergency Management and Assistance FEDERAL EMERGENCY... Title IX regulations do not apply to the membership practices of a voluntary youth service...

  2. 30 CFR 77.215-3 - Refuse piles: certification.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Refuse piles: certification. 77.215-3 Section... COAL MINES Surface Installations § 77.215-3 Refuse piles: certification. (a) Within 180 days following written notification by the District Manager that a refuse pile can present a hazard, the person...

  3. 30 CFR 77.215-1 - Refuse piles; identification.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Refuse piles; identification. 77.215-1 Section... COAL MINES Surface Installations § 77.215-1 Refuse piles; identification. A permanent identification marker, at least six feet high and showing the refuse pile identification number as assigned by...

  4. 30 CFR 77.215-2 - Refuse piles; reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Refuse piles; reporting requirements. 77.215-2... COAL MINES Surface Installations § 77.215-2 Refuse piles; reporting requirements. (a) The proposed location of a new refuse pile shall be reported to and acknowledged in writing by the District...

  5. 30 CFR 77.215 - Refuse piles; construction requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Refuse piles; construction requirements. 77.215... COAL MINES Surface Installations § 77.215 Refuse piles; construction requirements. (a) Refuse deposited on a pile shall be spread in layers and compacted in such a manner so as to minimize the flow of...

  6. 30 CFR 77.215-4 - Refuse piles; abandonment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Refuse piles; abandonment. 77.215-4 Section 77... MINES Surface Installations § 77.215-4 Refuse piles; abandonment. When a refuse pile is to be abandoned... refuse pile shall be abandoned in accordance with a plan submitted by the operator and approved by...

  7. 37 CFR 1.215 - Patent application publication.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Patent application publication. 1.215 Section 1.215 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions...

  8. 20 CFR 416.215 - You leave the United States.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false You leave the United States. 416.215 Section... Eligible § 416.215 You leave the United States. You lose your eligibility for SSI benefits for any month during all of which you are outside of the United States. If you are outside of the United States for...

  9. 34 CFR 668.215 - Average rates appeals.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Average rates appeals. 668.215 Section 668.215... Average rates appeals. (a) Eligibility. (1) You may appeal a notice of a loss of eligibility under § 668... as an average rate under § 668.202(d)(2). (2) You may appeal a notice of a loss of eligibility...

  10. 18 CFR 2.15 - Specified reasonable rate of return.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Specified reasonable rate of return. 2.15 Section 2.15 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL POLICY AND INTERPRETATIONS Statements of...

  11. Isomeric and ground-state decay of $^{215}$Bi

    CERN Document Server

    Kurpeta, J; Andreyev, A N; Äystö, J; De Smet, A; De Witte, H; Evensen, A H; Fedosseev, V; Franchoo, S; Górska, M; Grawe, H; Huhta, M; Huyse, M; Janas, Z; Jokinen, A; Karny, M; Kugler, E; Kurcewicz, W; Köster, U; Lettry, Jacques; Nieminen, A; Partes, K; Ramdhane, M; Ravn, H L; Rykaczewski, K; Szerypo, J; Van de Vel, K; Van Duppen, P; Weissman, L; Walter, G; Wöhr, A

    2003-01-01

    A new high-spin isomer in /sup 215/Bi, with a half-life of 36.9(6) s, has been identified at the PSB-ISOLDE on-line mass separator using the pulsed-release technique combined with the element selective RILIS source. A decay scheme of /sup 215m/Bi was constructed and complemented with the low-spin structure observed in /sup 215g/Bi decay. The population of a cascade on top of the ( nu g/sub 9/2/)/sub 9/2+//sup 5/ level in /sup 215/Po provides evidence for Gamow-Teller beta -decay of the high-spin /sup 215/Bi isomer. (15 refs).

  12. 49 CFR 215.111 - Defective plain bearing.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.111 Defective plain bearing. A railroad may not place or continue in service a car, if the car...

  13. 29 CFR 1603.215 - Record of hearings.

    Science.gov (United States)

    2010-07-01

    ... EXEMPT STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.215 Record of hearings. (a) All...

  14. 18 CFR 367.2150 - Account 215, Appropriated retained earnings.

    Science.gov (United States)

    2010-04-01

    ... NATURAL GAS ACT Balance Sheet Chart of Accounts Proprietary Capital § 367.2150 Account 215, Appropriated... ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING...

  15. 49 CFR Appendix C to Part 215 - FRA Freight Car Standards Defect Code

    Science.gov (United States)

    2010-10-01

    ... of the code is to establish a uniform language among FRA, States, and the railroad industry that will... Freight Car Truck. Car Bodies 215.121Defective Car Body. Draft System 215.123Defective Couplers. 215.... 215.121Defective car body. (A) Improper clearance—less than 21/2″ from top of rail. (B) Center sill...

  16. 48 CFR 215.404-76 - Reporting profit and fee statistics.

    Science.gov (United States)

    2010-10-01

    ... statistics. 215.404-76 Section 215.404-76 Federal Acquisition Regulations System DEFENSE ACQUISITION... Contract Pricing 215.404-76 Reporting profit and fee statistics. Follow the procedures at PGI 215.404-76 for reporting profit and fee statistics....

  17. CANCEROUS IMMUNOGLOBULINS AND CA215: IMPLICATIONS IN CANCER IMMUNOLOGY

    Directory of Open Access Journals (Sweden)

    Gregory Lee

    2012-01-01

    Full Text Available Immunoglobulins are typically expressed by B cells in our normal immune system. However, certain normal human tissues, such as hyperplastic epithelial cells, cells of the immunologically privileged sites and the majority of cancer cells, have also been found to be sites of immunoglobulin production. Current research is lacking in regards to the differential immunoglobulin expression, the underling mechanisms of action and the biological implications of these cancerous immunoglobulins in cancer immunology. This article reviews the etiology of atypical immunoglobulin expression in normal non-B cells and cancer cells, with emphasis on the exploration of the possible mechanisms of action and biological function of these atypical immunoglobulins, by means of specific biological probes. In contrast to immunoglobulins of B cell origins, atypical immunoglobulins were found to carry additional post-translational modifications, including a unique carbohydrateassociated epitope recognized by RP215 monoclonal antibody. This unique RP215-specific epitope enables us to differentiate between these two types of immunoglobulins. Atypical immunoglobulins expressed by cancer cells have been a common subject of interest in cancer immunology. Furthermore, the recent accumulation of experimental evidence has indicated that these atypical immunoglobulins are essential for the growth and proliferation of cancer cells under our normal immune environment. RP215 monoclonal antibody also reacts with many other cancer cell-expressed glycoproteins, known as CA215, on the cancer cell surface. Apoptosis of cultured cancer cells can be induced and growth inhibition of implanted tumors can be observed in nude mouse animal models. Therefore, humanized RP215 monoclonal antibody, which reacts mainly with surface bound CA215, may have the potential to be developed as an anti-cancer drug for the treatment of human cancers. A better understanding of cancer cell

  18. 49 CFR 215.113 - Defective plain bearing wedge.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.113 Defective plain bearing wedge. A railroad may not place or continue in service a car, if a plain bearing wedge on that car is— (a) Missing; (b) Cracked; (c) Broken; or (d) Not...

  19. 49 CFR 215.117 - Defective roller bearing adapter.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.117 Defective roller bearing adapter. A railroad may not place or continue in service a car, if the car has a roller bearing adapter that is— (a) Cracked or broken; (b) Not in its...

  20. 49 CFR 215.115 - Defective roller bearing.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.115 Defective roller bearing. (a) A railroad may not place or continue in service a car, if the car has— (1) A roller bearing that shows signs of having been overheated as evidenced by—...

  1. 49 CFR 215.107 - Defective plain bearing box: General.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Freight Car Components Suspension System § 215.107 Defective plain bearing box: General. A railroad may not place or continue in service a car, if the car has— (a) A plain bearing box that does not contain visible free oil; (b) A...

  2. 7 CFR 3052.215 - Relation to other audit requirements.

    Science.gov (United States)

    2010-01-01

    ... audited as a major program using the risk-based audit approach described in § 3052.520 and, if not, the... 7 Agriculture 15 2010-01-01 2010-01-01 false Relation to other audit requirements. 3052.215... FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND...

  3. 38 CFR 41.215 - Relation to other audit requirements.

    Science.gov (United States)

    2010-07-01

    ... using the risk-based audit approach described in § 41.520 and, if not, the estimated incremental cost... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Relation to other audit... (CONTINUED) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 41.215 Relation...

  4. 2 CFR 215.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Standards for financial management systems... Financial and Program Management § 215.21 Standards for financial management systems. (a) Federal awarding... information whenever practical. (b) Recipients' financial management systems shall provide for the...

  5. 20 CFR 628.215 - State Human Resource Investment Council.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false State Human Resource Investment Council. 628... PROGRAMS UNDER TITLE II OF THE JOB TRAINING PARTNERSHIP ACT State Planning § 628.215 State Human Resource..., 702, and 703 of the Act, establish a State Human Resource Investment Council (HRIC). The...

  6. 48 CFR 2052.215-75 - Proposal presentation and format.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Proposal presentation and....215-75 Proposal presentation and format. As prescribed at 2015.209-70(b)(1), the contracting officer... officer to fit the circumstances of the procurement. Proposal Presentation and Format (OCT 1999)...

  7. 7 CFR 215.7 - Requirements for participation.

    Science.gov (United States)

    2010-01-01

    ... authority under this part to support a nonprofit nutrition program for the elderly, including a program... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SPECIAL MILK PROGRAM FOR CHILDREN § 215.7 Requirements for...

  8. 34 CFR 682.215 - Income-based repayment plan.

    Science.gov (United States)

    2010-07-01

    ... the borrower first selected the income-based repayment plan; or (v) Received an economic hardship... received an economic hardship deferment on that loan, before the date the borrower qualified for income... 34 Education 3 2010-07-01 2010-07-01 false Income-based repayment plan. 682.215 Section...

  9. 31 CFR 0.215 - Possession of weapons and explosives.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Possession of weapons and explosives... OF THE TREASURY EMPLOYEE RULES OF CONDUCT Rules of Conduct § 0.215 Possession of weapons and explosives. (a) Employees shall not possess firearms, explosives, or other dangerous or deadly...

  10. 12 CFR 347.215 - Exemptions from deposit insurance requirement.

    Science.gov (United States)

    2010-01-01

    ... STATEMENTS OF GENERAL POLICY INTERNATIONAL BANKING Foreign Banks § 347.215 Exemptions from deposit insurance... depositing funds in connection with the issuance of a financial instrument by the branch for the transmission... importance of maintaining and improving the availability of credit to all sectors of the United...

  11. 20 CFR 725.215 - Determination of dependency; surviving spouse.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; surviving spouse...) § 725.215 Determination of dependency; surviving spouse. An individual who is the miner's surviving... service serving on active duty (as defined in § 404.1019 of this title), and the surviving spouse...

  12. 2 CFR 215.15 - Metric system of measurement.

    Science.gov (United States)

    2010-01-01

    ... Programs” (56 FR 35801, 3 CFR, 1991 Comp., p. 343). ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Metric system of measurement. 215.15 Section... measurement. The Metric Conversion Act, as amended by the Omnibus Trade and Competitiveness Act (15 U.S.C....

  13. 7 CFR 1260.215 - Patents, copyrights, inventions and publications.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Patents, copyrights, inventions and publications... AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Miscellaneous § 1260.215 Patents, copyrights, inventions and publications. (a) Any patents, copyrights, inventions or publications...

  14. 40 CFR 1065.215 - Pressure transducers, temperature sensors, and dewpoint sensors.

    Science.gov (United States)

    2010-07-01

    ... sensors, and dewpoint sensors. 1065.215 Section 1065.215 Protection of Environment ENVIRONMENTAL... Measurement of Engine Parameters and Ambient Conditions § 1065.215 Pressure transducers, temperature sensors, and dewpoint sensors. (a) Application. Use instruments as specified in this section to...

  15. 48 CFR 52.215-12 - Subcontractor Certified Cost or Pricing Data.

    Science.gov (United States)

    2010-10-01

    ... Cost or Pricing Data. 52.215-12 Section 52.215-12 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.215-12 Subcontractor Certified Cost or Pricing Data. As prescribed in 15.408(d), insert the following clause: Subcontractor Certified Cost or Pricing Data (OCT 2010) (a) Before...

  16. 48 CFR 5252.215-9000 - Submission of cost or pricing data.

    Science.gov (United States)

    2010-10-01

    ... pricing data. 5252.215-9000 Section 5252.215-9000 Federal Acquisition Regulations System DEPARTMENT OF THE... Clauses 5252.215-9000 Submission of cost or pricing data. As prescribed at 5215.407, insert the following provision: Submission of Cost or Pricing Data (NOV 1987) (a) It is expected that this contract will...

  17. 48 CFR 215.403-3 - Requiring information other than cost or pricing data.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Requiring information other than cost or pricing data. 215.403-3 Section 215.403-3 Federal Acquisition Regulations System... CONTRACTING BY NEGOTIATION Contract Pricing 215.403-3 Requiring information other than cost or pricing...

  18. 2 CFR 215.20 - Purpose of financial and program management.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Purpose of financial and program management... Financial and Program Management § 215.20 Purpose of financial and program management. Sections 215.21 through 215.28 prescribe standards for financial management systems, methods for making payments and...

  19. 12 CFR 215.5 - Additional restrictions on loans to executive officers of member banks.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Additional restrictions on loans to executive officers of member banks. 215.5 Section 215.5 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS... MEMBER BANKS (REGULATION O) § 215.5 Additional restrictions on loans to executive officers of...

  20. 41 CFR 102-37.215 - When must a SASP make a certification regarding lobbying?

    Science.gov (United States)

    2010-07-01

    ... certification regarding lobbying? 102-37.215 Section 102-37.215 Public Contracts and Property Management Federal... Property § 102-37.215 When must a SASP make a certification regarding lobbying? You are subject to the anti-lobbying certification and disclosure requirements in part 105-69 of this title when all of the...

  1. 33 CFR 162.215 - Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach. 162.215 Section 162.215 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... § 162.215 Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach. (a) The restricted area....

  2. 47 CFR 25.215 - Technical requirements for space stations in the Direct Broadcast Satellite Service.

    Science.gov (United States)

    2010-10-01

    ... the Direct Broadcast Satellite Service. 25.215 Section 25.215 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.215 Technical requirements for space stations in the Direct Broadcast Satellite Service. In addition to §...

  3. 48 CFR 52.215-2 - Audit and Records-Negotiation.

    Science.gov (United States)

    2010-10-01

    ...-Negotiation. 52.215-2 Section 52.215-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....215-2 Audit and Records—Negotiation. As prescribed in 15.209(b), insert the following clause: Audit and Records—Negotiation (OCT 2010) (a) As used in this clause, records includes books,...

  4. 50 CFR 226.215 - Critical habitat for the North Pacific Right Whale (Eubalaena japonica).

    Science.gov (United States)

    2010-10-01

    ... Right Whale (Eubalaena japonica). 226.215 Section 226.215 Wildlife and Fisheries NATIONAL MARINE... DESIGNATED CRITICAL HABITAT § 226.215 Critical habitat for the North Pacific Right Whale (Eubalaena japonica). (a) Primary Constituent Elements. The primary constituent elements of the North Pacific right...

  5. 30 CFR 250.215 - What hydrogen sulfide (H2S) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What hydrogen sulfide (H2S) information must accompany the EP? 250.215 Section 250.215 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Contents of Exploration Plans (ep) § 250.215 What hydrogen sulfide (H2S) information must accompany the...

  6. 48 CFR 52.215-17 - Waiver of Facilities Capital Cost of Money.

    Science.gov (United States)

    2010-10-01

    ... Capital Cost of Money. 52.215-17 Section 52.215-17 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.215-17 Waiver of Facilities Capital Cost of Money. As prescribed in 15.408(i), insert the following clause: Waiver of Facilities Capital Cost of Money (OCT 1997) The Contractor did...

  7. 48 CFR 52.215-16 - Facilities Capital Cost of Money.

    Science.gov (United States)

    2010-10-01

    ... Money. 52.215-16 Section 52.215-16 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....215-16 Facilities Capital Cost of Money. As prescribed in 15.408(h), insert the following provision: Facilities Capital Cost of Money (JUN 2003) (a) Facilities capital cost of money will be an allowable...

  8. Importance of the CEP215-pericentrin interaction for centrosome maturation during mitosis.

    Science.gov (United States)

    Kim, Seongjae; Rhee, Kunsoo

    2014-01-01

    At the onset of mitosis, the centrosome undergoes maturation, which is characterized by a drastic expansion of the pericentriolar material (PCM) and a robust increase in microtubule-organizing activity. CEP215 is one of the major PCM components which accumulates at the centrosome during mitosis. The depletion phenotypes indicate that CEP215 is essential for centrosome maturation and bipolar spindle formation. Here, we performed a series of knockdown-rescue experiments to link the protein-protein interaction properties of CEP215 to its biological functions. The results showed that CEP215 and pericentrin, another major PCM component, is interdependent for their accumulation at the spindle poles during mitosis. As a result, The CEP215-pericentrin interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis. On the other hand, CEP215 interaction with γ-tubulin is dispensable for centrosome maturation. Our results provide an insight how PCM components are assembled to form a spindle pole during mitosis.

  9. THz imaging Si MOSFET system design at 215 GHz

    Science.gov (United States)

    Sacco, Andrew P.; Newman, J. Daniel; Lee, Paul P. K.; Fourspring, Kenneth D.; Osborn, John H.; Fiete, Robert D.; Bocko, Mark F.; Ignjatovic, Zeljko; Pipher, Judith L.; McMurtry, Craig W.; Zhang, Xi-Cheng; Dayalu, Jagannath; Fertig, Gregory J.; Zhang, Chao; Ninkov, Zoran

    2014-05-01

    Exelis Geospatial Systems and its CEIS partners at the University of Rochester and Rochester Institute of Technology are developing an active THz imaging focal plane for use in standoff detection, molecular spectroscopy and penetration imaging. This activity is focused on the detection of radiation centered on the atmospheric window at 215.5 GHz. The pixel consists of a direct coupled bowtie antenna utilizing a 0.35 μm CMOS technology MOSFET, where the plasmonic effect is the principle method of detection. With an active THz illumination source such as a Gunn diode, a design of catadioptric optical system is presented to achieve a resolution of 3.0 mm at a standoff distance of 1.0 m. The primary value of the initial system development is to predict the optical performance of a THz focal plane for active imaging and to study the interaction of THz radiation with various materials.

  10. 48 CFR 253.215-70 - DD Form 1547, Record of Weighted Guidelines Application.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1547, Record of... Forms 253.215-70 DD Form 1547, Record of Weighted Guidelines Application. Follow the procedures at PGI 253.215-70 for completing DD Form 1547....

  11. 48 CFR 215.404-70 - DD Form 1547, Record of Weighted Guidelines Method Application.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1547, Record of... TYPES CONTRACTING BY NEGOTIATION Contract Pricing 215.404-70 DD Form 1547, Record of Weighted Guidelines Method Application. Follow the procedures at PGI 215.404-70 for use of DD Form 1547 whenever a...

  12. 25 CFR 215.21 - Payment of gross production tax on lead and zinc.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Payment of gross production tax on lead and zinc. 215.21... ZINC MINING OPERATIONS AND LEASES, QUAPAW AGENCY § 215.21 Payment of gross production tax on lead and zinc. The superintendent of the Quapaw Indian Agency is hereby authorized and directed to pay at...

  13. 48 CFR 215.407-5-70 - Disclosure, maintenance, and review requirements.

    Science.gov (United States)

    2010-10-01

    ... CONTRACTING BY NEGOTIATION Contract Pricing 215.407-5-70 Disclosure, maintenance, and review requirements. (a) Definitions. (1) Acceptable estimating system is defined in the clause at 252.215-7002, Cost Estimating System... pricing data were required; or (ii) In its preceding fiscal year, the contractor received DoD...

  14. 48 CFR 52.215-15 - Pension adjustments and asset reversions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Pension adjustments and asset reversions. 52.215-15 Section 52.215-15 Federal Acquisition Regulations System FEDERAL ACQUISITION... the numerator of the fraction at 48 CFR 9904.413-50(c)(12)(vi) shall be the sum of the pension...

  15. 49 CFR Appendix A to Part 215 - Railroad Freight Car Components

    Science.gov (United States)

    2010-10-01

    ... Part 215—Railroad Freight Car Components List of components whose use is restricted by § 215.203 of... with letters “RJ” stamped on the end of the journal. C.Couplers: 1. AAR type “D”, top or bottom.... 2. Farlow draft attachment. E.Plain journal bearings: Cartridge type. F.Roller bearings: 1....

  16. 21 CFR 1404.215 - Which nonprocurement transactions are not covered transactions?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Which nonprocurement transactions are not covered transactions? 1404.215 Section 1404.215 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE... transaction that the Office of National Drug Control Policy needs to respond to a national or...

  17. 22 CFR 1006.215 - Which nonprocurement transactions are not covered transactions?

    Science.gov (United States)

    2010-04-01

    ... covered transactions? 1006.215 Section 1006.215 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE... excepted). For example, if a person receives social security benefits under the Supplemental Security Income provisions of the Social Security Act, 42 U.S.C. 1301 et seq., those benefits are not...

  18. 9 CFR 113.215 - Bovine Virus Diarrhea Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Bovine Virus Diarrhea Vaccine, Killed Virus. 113.215 Section 113.215 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS...

  19. 48 CFR 1652.215-70 - Rate Reduction for Defective Pricing or Defective Cost or Pricing Data.

    Science.gov (United States)

    2010-10-01

    ... Defective Pricing or Defective Cost or Pricing Data. 1652.215-70 Section 1652.215-70 Federal Acquisition... CLAUSES AND FORMS CONTRACT CLAUSES Texts of FEHBP Clauses 1652.215-70 Rate Reduction for Defective Pricing or Defective Cost or Pricing Data. As prescribed in 1615.407-1, the following clause shall...

  20. 12 CFR 215.9 - Disclosure of credit from member banks to executive officers and principal shareholders.

    Science.gov (United States)

    2010-01-01

    ... executive officers and principal shareholders. 215.9 Section 215.9 Banks and Banking FEDERAL RESERVE SYSTEM... SHAREHOLDERS OF MEMBER BANKS (REGULATION O) § 215.9 Disclosure of credit from member banks to executive officers and principal shareholders. (a) Definitions. For the purposes of this section, the...

  1. 8 CFR 215.6 - Departure from the Canal Zone, the Trust Territory of the Pacific Islands, or outlying...

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Departure from the Canal Zone, the Trust Territory of the Pacific Islands, or outlying possessions of the United States. 215.6 Section 215.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CONTROLS OF ALIENS DEPARTING FROM THE UNITED STATES § 215.6...

  2. 49 CFR 40.215 - What information about the DER do employers have to provide to BATs and STTs?

    Science.gov (United States)

    2010-10-01

    ... to provide to BATs and STTs? 40.215 Section 40.215 Transportation Office of the Secretary of... Personnel § 40.215 What information about the DER do employers have to provide to BATs and STTs? As an employer, you must provide to the STTs and BATs the name and telephone number of the appropriate DER (and...

  3. File list: Pol.Emb.05.RpII215.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Emb.05.RpII215.AllCell dm3 RNA polymerase RpII215 Embryo SRX859013,SRX859009,SR...X859007,SRX859011 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/assembled/Pol.Emb.05.RpII215.AllCell.bed ...

  4. 25 CFR 215.23a - Suspension of operations and production on leases for minerals other than oil and gas.

    Science.gov (United States)

    2010-04-01

    ... minerals other than oil and gas. 215.23a Section 215.23a Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING OPERATIONS AND LEASES, QUAPAW AGENCY § 215.23a Suspension of operations and production on leases for minerals other than oil and gas. The provisions...

  5. 48 CFR 215.404-72 - Modified weighted guidelines method for nonprofit organizations other than FFRDCs.

    Science.gov (United States)

    2010-10-01

    ... METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 215.404-72 Modified weighted guidelines method for nonprofit organizations other than FFRDCs. (a) Definition. As used in this subpart,...

  6. Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells

    Directory of Open Access Journals (Sweden)

    Formentini Andrea

    2010-04-01

    Full Text Available Abstract Background Translational control mediated by non-coding microRNAs (miRNAs plays a key role in the mechanism of cellular resistance to anti-cancer drug treatment. Dihydrofolate reductase (DHFR and thymidylate synthase (TYMS, TS are two of the most important targets for antifolate- and fluoropyrimidine-based chemotherapies in the past 50 years. In this study, we investigated the roles of miR-215 in the chemoresistance to DHFR inhibitor methotrexate (MTX and TS inhibitor Tomudex (TDX. Results The protein levels of both DHFR and TS were suppressed by miR-215 without the alteration of the target mRNA transcript levels. Interestingly, despite the down-regulation of DHFR and TS proteins, ectopic expression of miR-215 resulted in a decreased sensitivity to MTX and TDX. Paradoxically, gene-specific small-interfering RNAs (siRNAs against DHFR or TS had the opposite effect, increasing sensitivity to MTX and TDX. Further studies revealed that over-expression of miR-215 inhibited cell proliferation and triggered cell cycle arrest at G2 phase, and that this effect was accompanied by a p53-dependent up-regulation of p21. The inhibitory effect on cell proliferation was more pronounced in cell lines containing wild-type p53, but was not seen in cells transfected with siRNAs against DHFR or TS. Moreover, denticleless protein homolog (DTL, a cell cycle-regulated nuclear and centrosome protein, was confirmed to be one of the critical targets of miR-215, and knock-down of DTL by siRNA resulted in enhanced G2-arrest, p53 and p21 induction, and reduced cell proliferation. Additionally, cells subjected to siRNA against DTL exhibited increased chemoresistance to MTX and TDX. Endogenous miR-215 was elevated about 3-fold in CD133+HI/CD44+HI colon cancer stem cells that exhibit slow proliferating rate and chemoresistance compared to control bulk CD133+/CD44+ colon cancer cells. Conclusions Taken together, our results indicate that miR-215, through the suppression

  7. 31 CFR 585.215 - Conveyances and cargo suspected of being in violation of United Nations sanctions; detention...

    Science.gov (United States)

    2010-07-01

    ... being in violation of United Nations sanctions; detention; blocking. 585.215 Section 585.215 Money and... and cargo suspected of being in violation of United Nations sanctions; detention; blocking. (a) Except... § 585.201, but which are suspected of a violation of United Nations Security Council Resolutions No....

  8. 48 CFR 52.215-18 - Reversion or Adjustment of Plans for Postretirement Benefits (PRB) Other Than Pensions.

    Science.gov (United States)

    2010-10-01

    ... Plans for Postretirement Benefits (PRB) Other Than Pensions. 52.215-18 Section 52.215-18 Federal... Postretirement Benefits (PRB) Other Than Pensions. As prescribed in 15.408(j), insert the following clause: Reversion or Adjustment of Plans for Postretirement Benefits (PRB) Other Than Pensions (JUL 2005) (a)...

  9. 30 CFR 204.215 - Are the information collection requirements in this subpart approved by the Office of Management...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Are the information collection requirements in this subpart approved by the Office of Management and Budget (OMB)? 204.215 Section 204.215 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT...

  10. 12 CFR 215.7 - Extensions of credit outstanding on March 10, 1979.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Extensions of credit outstanding on March 10... (REGULATION O) § 215.7 Extensions of credit outstanding on March 10, 1979. (a) Any extension of credit that was outstanding on March 10, 1979, and that would, if made on or after March 10, 1979, violate §...

  11. 27 CFR 24.215 - Wine or wine products not for beverage use.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Wine or wine products not... AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.215 Wine or wine products not for beverage use. (a) General. Wine, or wine products made from...

  12. 47 CFR 15.215 - Additional provisions to the general radiated emission limitations.

    Science.gov (United States)

    2010-10-01

    ... RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.215 Additional provisions to the general radiated emission limitations. (a) The regulations in §§ 15.217 through... frequency bands shown in these alternative provisions must be attenuated to the emission limits shown...

  13. 49 CFR 215.109 - Defective plain bearing box: Journal lubrication system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Defective plain bearing box: Journal lubrication... Freight Car Components Suspension System § 215.109 Defective plain bearing box: Journal lubrication system...) Metal parts contacting the journal; or (e) Is— (1) Missing; or (2) Not in contact with the journal....

  14. Regulation of p53 expression and apoptosis by vault RNA2-1-5p in cervical cancer cells.

    Science.gov (United States)

    Kong, Lu; Hao, Qi; Wang, Ying; Zhou, Ping; Zou, Binbin; Zhang, Yu-xiang

    2015-09-29

    nc886 or VRNA2-1 has recently been identified as a noncoding RNA instead of a vault RNA or a pre-microRNA. Several studies have reported that pre-miR-886 plays a tumor-suppressive role in a wide range of cancer cells through its activity as a cellular protein kinase RNA-activated (PKR) ligand and repressor. However, by sequencing stem-PCR products, we found that a microRNA originating from this precursor, vault RNA2-1-5p (VTRNA2-1-5p), occurs in cervical cancer cells. The expression levels of the predicted targets of VTRNA2-1-5p are negatively correlated with VTRNA2-1-5p levels by quantitative reversion transcription PCR (qRT-PCR). Previous results have shown that VTRNA2-1-5p is overexpressed in human cervical squamous cell carcinomas (CSCCs) compared with adjacent healthy tissues. Inhibition of VTRNA2-1-5p increases Bax protein expression and apoptotic cell death in cervical cancer cells. Our findings suggest that VTRNA2-1-5p has oncogenic activity related to the progression of cervical cancer. Here, we report that VTRNA2-1-5p directly targeted p53 expression and functioned as an oncomir in cervical cancer. VTRNA2-1-5p inhibition decreased cervical cancer cell invasion, proliferation, and tumorigenicity while increasing apoptosis and p53 expression. Interestingly, VTRNA2-1-5p inhibition also increased cisplatin-induced apoptosis of HeLa and SiHa cells. In human clinical cervical cancer specimens, low p53 expression and high VTRNA2-1-5p expression were positively associated.In addition, VTRNA2-1-5p was found to directly target the 5' and 3' untranslated regions (UTRs) of p53. We propose that VTRNA2-1-5p is a direct regulator of p53 and suggest that it plays an essential role in the apoptosis and proliferation of cervical cancer cells.

  15. Intestinal renal metabolism of L-citrulline and L-arginine following enteral or parenteral infusion of L-alanyl-L-[2,15N]glutamine or L-[2,15N]glutamine in mice.

    Science.gov (United States)

    Boelens, Petra G; van Leeuwen, Paul A M; Dejong, Cornelis H C; Deutz, Nicolaas E P

    2005-10-01

    Previously, we observed increased plasma arginine (ARG) concentrations after glutamine (GLN)-enriched diets, in combination with clinical benefits. GLN delivers nitrogen for ARG synthesis, and the present study was designed to quantify the interorgan relationship of exogenous L-GLN or GLN dipeptide, by enteral or parenteral route, contributing to intestinal citrulline (CIT) and renal de novo ARG synthesis in mice. To study this, we used a multicatheterized mouse model with Swiss mice (n = 43) in the postabsorptive state. Stable isotopes were infused into the jugular vein or into the duodenum {per group either free L-[2,(15)N]GLN or dipeptide L-ALA-L-[2,(15)N]GLN, all with L-[ureido-(13)C-(2)H(2)]CIT and L-[guanidino-(15)N(2)-(2)H(2)]ARG} to establish renal and intestinal ARG and CIT metabolism. Blood flow was measured using (14)C-para-aminohippuric acid. Net intestinal CIT release, renal uptake of CIT, and net renal ARG efflux was found, as assessed by arteriovenous flux measurements. Quantitatively, more de novo L-[2,(15)N]CIT was produced when free L-[2,(15)N]GLN was given than when L-ALA-L-[2,(15)N]GLN was given, whereas renal de novo L-[2,(15)N]ARG was similar in all groups. In conclusion, the intestinal-renal axis is hereby proven in mice in that L-[2,(15)N]GLN or dipeptide were both converted into de novo renal L-[2,(15)N]ARG; however, not all was derived from intestinal L-[2,(15)N]CIT production. In this model, the feeding route and form of GLN did not influence de novo renal ARG production derived from GLN.

  16. 48 CFR 215.403-5 - Instructions for submission of cost or pricing data or information other than cost or pricing data.

    Science.gov (United States)

    2010-10-01

    ... submission of cost or pricing data or information other than cost or pricing data. 215.403-5 Section 215.403... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 215.403-5 Instructions for submission of cost or pricing data or information other than cost or pricing data. When...

  17. 48 CFR 853.215-70 - VA Form 10-1170, Application for Furnishing Nursing Home Care to Beneficiaries of VA.

    Science.gov (United States)

    2010-10-01

    ..., Application for Furnishing Nursing Home Care to Beneficiaries of VA. 853.215-70 Section 853.215-70 Federal... 853.215-70 VA Form 10-1170, Application for Furnishing Nursing Home Care to Beneficiaries of VA. VA Form 10-1170, Application for Furnishing Nursing Home Care to Beneficiaries of VA, will be used...

  18. Self-Biased 215MHz Magnetoelectric NEMS Resonator for Ultra-Sensitive DC Magnetic Field Detection

    OpenAIRE

    Tianxiang Nan; Yu Hui; Matteo Rinaldi; Sun, Nian X.

    2013-01-01

    High sensitivity magnetoelectric sensors with their electromechanical resonance frequencies < 200 kHz have been recently demonstrated using magnetostrictive/piezoelectric magnetoelectric heterostructures. In this work, we demonstrate a novel magnetoelectric nano-electromechanical systems (NEMS) resonator with an electromechanical resonance frequency of 215 MHz based on an AlN/(FeGaB/Al2O3) × 10 magnetoelectric heterostructure for detecting DC magnetic fields. This magnetoelectric NEMS resonat...

  19. 'Aanhalings' van die Ou Testament deur die Nuwe Testament: Hosea 11:1/Matteus 2:15

    Directory of Open Access Journals (Sweden)

    W. S. Prinsloo

    1986-01-01

    Full Text Available Quotations of the Old Testament in the New Testament: Hosea 11:1/Matthew 2:15 The quotation of Hosea 11:1 in Matthew 2:15 does not cancel the original meaning of Hosea 11:1. Neither can Matthew 2 be implemented as a criterium to interpret Hosea 11. Both Hosea 11 and Matthew 2 have their own unique message and both have to be taken equally seriously into consideration.

  20. Oxidative stress and mitochondrial functions in the intestinal Caco-2/15 cell line.

    Directory of Open Access Journals (Sweden)

    Rame Taha

    Full Text Available BACKGROUND: Although mitochondrial dysfunction and oxidative stress are central mechanisms in various pathological conditions, they have not been extensively studied in the gastrointestinal tract, which is known to be constantly exposed to luminal oxidants from ingested foods. Key among these is the simultaneous consumption of iron salts and ascorbic acid, which can cause oxidative damage to biomolecules. METHODOLOGY/PRINCIPAL FINDINGS: The objective of the present work was to evaluate how iron-ascorbate (FE/ASC-mediated lipid peroxidation affects mitochondrion functioning in Caco-2/15 cells. Our results show that treatment of Caco-2/15 cells with FE/ASC (0.2 mM/2 mM (1 increased malondialdehyde levels assessed by HPLC; (2 reduced ATP production noted by luminescence assay; (3 provoked dysregulation of mitochondrial calcium homeostasis as evidenced by confocal fluorescence microscopy; (4 upregulated the protein expression of cytochrome C and apoptotic inducing factor, indicating exaggerated apoptosis; (5 affected mitochondrial respiratory chain complexes I, II, III and IV; (6 elicited mtDNA lesions as illustrated by the raised levels of 8-OHdG; (7 lowered DNA glycosylase, one of the first lines of defense against 8-OHdG mutagenicity; and (8 altered the gene expression and protein mass of mitochondrial transcription factors (mtTFA, mtTFB1, mtTFB2 without any effects on RNA Polymerase. The presence of the powerful antioxidant BHT (50 microM prevented the occurrence of oxidative stress and most of the mitochondrial abnormalities. CONCLUSIONS/SIGNIFICANCE: Collectively, our findings indicate that acute exposure of Caco-2/15 cells to FE/ASC-catalyzed peroxidation produces harmful effects on mitochondrial functions and DNA integrity, which are abrogated by the powerful exogenous BHT antioxidant. Functional derangements of mitochondria may have implications in oxidative stress-related disorders such as inflammatory bowel diseases.

  1. Self-Biased 215MHz Magnetoelectric NEMS Resonator for Ultra-Sensitive DC Magnetic Field Detection

    Science.gov (United States)

    Nan, Tianxiang; Hui, Yu; Rinaldi, Matteo; Sun, Nian X.

    2013-06-01

    High sensitivity magnetoelectric sensors with their electromechanical resonance frequencies NEMS) resonator with an electromechanical resonance frequency of 215 MHz based on an AlN/(FeGaB/Al2O3) × 10 magnetoelectric heterostructure for detecting DC magnetic fields. This magnetoelectric NEMS resonator showed a high quality factor of 735, and strong magnetoelectric coupling with a large voltage tunable sensitivity. The admittance of the magnetoelectric NEMS resonator was very sensitive to DC magnetic fields at its electromechanical resonance, which led to a new detection mechanism for ultra-sensitive self-biased RF NEMS magnetoelectric sensor with a low limit of detection of DC magnetic fields of ~300 picoTelsa. The magnetic/piezoelectric heterostructure based RF NEMS magnetoelectric sensor is compact, power efficient and readily integrated with CMOS technology, which represents a new class of ultra-sensitive magnetometers for DC and low frequency AC magnetic fields.

  2. Mejoras en el apuntado del telescopio de 2,15 mts de CASLEO

    Science.gov (United States)

    Aballay, J. L.; Casagrande, A. R.; Pereyra, P. F.; Marún, A. H.

    Con el objeto de optimizar el funcionamiento del telescopio de 2,15 mts. de CASLEO, se están eliminando los motores de calar, de guía y mecánica asociada. Para ésto, se están diseñando dos electrónicas que gobernarán, solamente, el motor de slew y el de tracking. Con el control del motor de slew se realizarán las funciones de slew y calar, controlando desde una PC la placa que maneja las rampas de velocidad. De este modo, el movimiento será programado y por lo tanto, más suave y preciso. Con el control del motor de tracking, a través de un generador de frecuencias programable desde una PC, se proveerá los movimientos necesarios para el tracking y guía.

  3. Space charge in drift chambers operated with the Xe, CO$_{2}$(15\\%) mixture

    CERN Document Server

    Andronic, A; Blume, C; Braun-Munzinger, P; Bucher, D; Busch, O; Catanescu, V; Ciobanu, M; Daues, H W; Emschermann, D; Fateev, O V; Foka, Y; Garabatos, C; Gunji, T; Herrmann, N; Inuzuka, M; Kislov, E; Lindenstruth, V; Ludolphs, W; Mahmoud, T; Petracek, V; Petrovici, M; Rusanov, I R; Sandoval, A; Santo, R; Schicker, R; Simon, R S; Smykov, L P; Soltveit, H K; Stachel, J; Stelzer, H; Tsiledakis, G; Vulpescu, B; Wessels, J P; Windelband, B; Xu, C; Zaudtke, O; Zanevsky, Yu; Yurevich, V

    2004-01-01

    Using prototype modules of the ALICE Transition Radiation Detector (TRD) we investigate space-charge effects and the dependence of the pion rejection performance on the incident angle of the ionizing particle. The average pulse height distributions in the drift chambers operated with the Xe, CO //2(15%) mixture provide quantitative information on the gas gain reduction due to space charge accumulating during the drift of the primary ionization. Our results demonstrate that the pion rejection performance of a TRD is better for tracks which are not at normal incidence to the anode wires. We present detailed simulations of detector signals, which reproduce the measurements and lend strong support to our interpretation of the measurements in terms of space-charge effects.

  4. Comparison of Si+n and Ge+n(n=2-15) Cationic Structures

    Institute of Scientific and Technical Information of China (English)

    QIN Wei; ZANG Qing-jun; LU Wen-cai; WANG Cai-zhuang; HO Kai-ming

    2011-01-01

    We designed and optimized a large number of the isomers of Si12+ at the level of density functional theory (DFT)-B3LYP/6-311++G(d) using the Gaussian 03 software package. An unambiguous structure of the Si12+ cluster is presented, whose IR spectrum agrees well with the experiment result. The most stable geometric structures of Ge+n(n=2-15) clusters were determined by the all-electron PBE/DND method in DMol3 of the Material Studio Package, and compared with those of the corresponding Si+n geometries. Most structures of Ge+n and Si+n are similar except the ones of those for n=9, 12, 13 and 14, and the pentagonal bipyramid motif and the tri-capped trigonal prism(TTP) motif often appear in the Si+n and Ge+n(n=7-15) structures(except for Si14+).

  5. miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomas.

    Science.gov (United States)

    Choi, Dong Ho; Park, Sang Jae; Kim, Hark Kyun

    2015-06-01

    Distinguishing ampullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory microRNAs warrant future validation.

  6. 41 CFR 102-118.215 - May my agency pay a TSP any extra fees to pay for the preparation and use of the GBL or GTR?

    Science.gov (United States)

    2010-07-01

    ... any extra fees to pay for the preparation and use of the GBL or GTR? 102-118.215 Section 102-118.215... Billing Documents Terms and Conditions Governing Acceptance and Use of A Government Bill of Lading (gbl... TSP any extra fees to pay for the preparation and use of the GBL or GTR? No, your agency must not...

  7. 48 CFR 52.215-20 - Requirements for Certified Cost or Pricing Data and Data Other Than Certified Cost or Pricing Data.

    Science.gov (United States)

    2010-10-01

    ... Certificate of Current Cost or Pricing Data, as prescribed by FAR 15.406-2. (End of provision) Alternate I... Cost or Pricing Data and Data Other Than Certified Cost or Pricing Data. 52.215-20 Section 52.215-20... Certified Cost or Pricing Data and Data Other Than Certified Cost or Pricing Data. As prescribed in...

  8. 40 CFR 1068.215 - What are the provisions for exempting manufacturer-owned engines/equipment?

    Science.gov (United States)

    2010-07-01

    ... PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS GENERAL COMPLIANCE PROVISIONS FOR ENGINE PROGRAMS... least the following items: (i) The label heading “EMISSION CONTROL INFORMATION”. (ii) Your corporate... ENGINE IS EXEMPT UNDER 40 CFR 1068.210 OR 1068.215 FROM EMISSION STANDARDS AND RELATED REQUIREMENTS.”...

  9. Zum 215. Gebutstag von Admiral Ferdinand Baron von Wrangell : (29. Dezember 1797 - 25. 25. Mai 1870) / Peter Krienitz

    Index Scriptorium Estoniae

    Krienitz, Peter

    2012-01-01

    Admiral Ferdinand Baron von Wrangellist tema 215. sünniaastapäeva puhul. Silmapaistavast Kirde-Siberi uurijast. Tema poliitilisest tegevusest ja elust Roela mõisas. Ferdinand Baroni poolt seatud viisil tähistati jõulusid Roelas kuni 1944. aasta lõpuni.

  10. 215 GHz VLBI observations: Detection of fringes on the 1147 KM baseline Pico Veleta-Plateau de Bure

    NARCIS (Netherlands)

    Greve, A.; Torres, M.; Wink, J. E.; Grewing, M.; Wild, W.; Alcolea, J.; Barcia, A.; Colomer, F.; de Vincente, P.; Gomez-Gonzalez, J.; Lopez-Fernandez, I.; Graham, D. A.; Krichbaum, T. P.; Schwartz, R.; Standke, K. J.; Witzel, A.; Baudry, A.

    1995-01-01

    In a VLBI test experiment between the IRAM 3Om telescope at Pico Veleta,Spain, and one 15-m telescope of the IRAM interferometer on Plateau de Bure, France, we detected fringes at 215 GHz with signal to noise ratios between 6 8 and 10.2. On this 1147km long distance, of 0.28-0.43 milli arcseconds pr

  11. Foco Nasmyth para el telescopio 2,15mts. de CASLEO

    Science.gov (United States)

    Casagrande, A. R.

    En principio, este proyecto intenta lograr el mayor aprovechamiento posible del instrumental que se dispone, buscando la manera de optimizar y hacer más eficiente el servicio que brinda el CASLEO a la comunidad astronómica. El mismo consiste en utilizar dispositivos ya existentes en el telescopio, y darle una utilidad. Tal es el caso del camino óptico destinado al foco Coude. Si tenemos en cuenta que disponemos de un tercer espejo Coude, con todos sus mecanismos automatizados, (actualmente sin uso), una distancia apropiada del plano focal, el espacio y el lugar físico necesario para instalar un periférico, es posible la habilitación de un foco Nasmyth en el telescopio 2,15mts. El hecho de contar con este nuevo foco, redundará en importantes beneficios. En primer lugar, posibilitará la observación, casi simultánea, con dos instrumentos. Otro aspecto a tener en cuenta, es que disminuirá el frecuente cambio del instrumental periférico, motivo este que degrada su ideal puesta a punto. Por último, también de interés, es de destacar su escaso costo de ejecución.

  12. Autoguía para el telescopio 2,15 mts de CASLEO

    Science.gov (United States)

    Aballay, J. A.; Casagrande, A. R.; Pereyra, P. F.; Marún, A. H.

    Se está desarrollando un sistema de autoguía para el telescopio de 2,15 mts. El mismo se realizará aprovechando el Offset Guider. Al ocular móvil de éste se vinculará alguna cámara digital (ST4-ST7-CH250) para lograr la visión del objeto. El funcionamiento del equipo será el siguiente: primero, dadas las coordenadas del objeto a observar, se tomarán las coordenadas del telescopio para que, a través de una base de datos, se determine un campo de objetos que sirvan para la cámara de visión, luego, la PC obtendrá el offset entre la estrella de observación y la estrella seleccionada como guía, este valor será trasladado a los motores que posicionarán en forma automática el ocular. Una vez que la estrella es visualizada en la cámara (monitor de PC ) se correrá el programa que guiará el telescopio automáticamente.

  13. Biopsy of human morula-stage embryos: outcome of 215 IVF/ICSI cycles with PGS.

    Directory of Open Access Journals (Sweden)

    Elena E Zakharova

    Full Text Available Preimplantation genetic diagnosis (PGD is commonly performed on biopsies from 6-8-cell-stage embryos or blastocyst trophectoderm obtained on day 3 or 5, respectively. Day 4 human embryos at the morula stage were successfully biopsied. Biopsy was performed on 709 morulae from 215 ICSI cycles with preimplantation genetic screening (PGS, and 3-7 cells were obtained from each embryo. The most common vital aneuploidies (chromosomes X/Y, 21 were screened by fluorescence in situ hybridization (FISH. No aneuploidy was observed in 72.7% of embryos, 91% of those developed to blastocysts. Embryos were transferred on days 5-6. Clinical pregnancy was obtained in 32.8% of cases, and 60 babies were born. Patients who underwent ICSI/PGS treatment were compared with those who underwent standard ICSI treatment by examining the percentage of blastocysts, pregnancy rate, gestational length, birth height and weight. No significant differences in these parameters were observed between the groups. Day 4 biopsy procedure does not adversely affect embryo development in vitro or in vivo. The increased number of cells obtained by biopsy of morulae might facilitate diagnostic screening. There is enough time after biopsy to obtain PGD results for embryo transfer on day 5-6 in the current IVF cycle.

  14. Improved energy of the 21.5 keV M1 + E2 nuclear transition in {sup 151}Eu

    Energy Technology Data Exchange (ETDEWEB)

    Inoyatov, A.Kh. [JINR, Laboratory of Nuclear Problems, Dubna, Moscow Region (Russian Federation); National University, Institute of Applied Physics, Tashkent (Uzbekistan); Kovalik, A. [JINR, Laboratory of Nuclear Problems, Dubna, Moscow Region (Russian Federation); Nuclear Physics Institute of the ASCR, Rez near Prague (Czech Republic); Filosofov, D.V.; Perevoshchikov, L.L. [JINR, Laboratory of Nuclear Problems, Dubna, Moscow Region (Russian Federation); Rysavy, M. [Nuclear Physics Institute of the ASCR, Rez near Prague (Czech Republic); Baimukhanova, A. [JINR, Laboratory of Nuclear Problems, Dubna, Moscow Region (Russian Federation); Institute of Nuclear Physics, Almaty (Kazakhstan)

    2016-05-15

    Using internal conversion electron spectroscopy, improved energy 21 541.5±0.5 eV was determined for the 21.5 keV M1+E2 nuclear transition in {sup 151}Eu populated in the electron capture decay of {sup 151}Gd. This value was found to agree well with the present adopted value but is much more accurate. A value of 0.0305±0.0011 derived for the E2 admixture parameter vertical stroke δ(E2/M1) vertical stroke from the measured conversion electron line intensities corresponds to the present adopted value. A possible effect of nuclear structure on the multipolarity of the 21.5 keV transition was also investigated. (orig.)

  15. 215例血友病A患者因子Ⅷ抑制物形成的环境因素研究%Environmental factors for inhibitor formation of factor Ⅷ in 215 patients with hemophilia A

    Institute of Scientific and Technical Information of China (English)

    周璇; 孙竞; 李敏; 李文卿; 宋晓玲; 刘阳

    2011-01-01

    目的 研究中国血友病A患者因子Ⅷ(FⅧ)抑制物形成的环境因素.方法 监测215例血友病A患者在2年(2007年6月至2009年6月)的连续随访中,FⅧ抑制物发生、变化及转归,并对FⅧ抑制物形成的环境因素进行回顾性分析.结果 215例血友病A患者随访2年FⅧ抑制物累积发生率为11.6%(25/215).FⅧ抑制物形成的环境因素的多变量分析结果示:①输注原因中短期低剂量预防治疗比按需治疗形成FⅧ抑制物的风险低(OR=0.037,95%CI为 0.002~0.616); ②血友病越严重,累积暴露日越少,FⅧ抑制物形成风险越高;③发生严重出血事件是FⅧ抑制物形成的高危因素(OR=117.045,95%CI为19.333~708.617); ④输注形式和发生重大感染事件与FⅧ抑制物形成无关.结论 在中国目前治疗情况下,血友病患者 FⅧ抑制物的形成可能与血友病严重程度、输注原因(预防治疗或按需治疗)、累积暴露日和是否发生严重出血事件有关.%Objective To study the environmental factors for inhibitor formation of factor Ⅷ in 215 Chinese patients with hemophilia A. Methods Formation, change and transformation of factor Ⅷ were observed in 215 Chinese patients with hemophilia A during the 2-year follow-up period from June 2007 to June 2009. The environmental factors for inhibitor formation of factor Ⅷ were retrospectively analyzed. Results The cumulative incidence of hemophilia A in the 215 Chinese patients during the 2-year follow-up period was 11.6% (25/215). Multivariate analysis showed that the risk for inhibitor formation of factor Ⅷ was lower in short-term low-dose preventive treatment than in on-demand treatment (OR =0. 037, 95% CI =0. 002 -0.616). The higher the severity of hemophilia was, the less the cumulative exposure day was, and the greater the risk for the inhibitor formation of factor Ⅷ was. Severe bleeding episodes was a high risk factor for the inhibitor formation of factor Ⅷ ( OR = 117. 045

  16. Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients

    Directory of Open Access Journals (Sweden)

    Daniela Assis do VALE

    Full Text Available Abstract Oral manifestations are common findings in human immunodeficiency virus (HIV infected patients and frequently influence the overall health. Oral hairy leukoplakia (OHL is strongly associated with HIV infection demonstrating its relationship with the individual’s immune status and progression of immunosuppression. This study aims to retrospectively evaluate OHL in HIV patients, analyzing its incidence, demographic aspects and possible changes in clinical and epidemiological profile of the disease over 17 years. The records of 1600 HIV-infected patients were reviewed. The data were correlated and analyzed, considering HIV exposure category, age, gender, harmful habits, CD4 level, use and type of antiretroviral. OHL was observed in 215 (13.4% patients. Most were men in the fourth decade of life, 171 (79.5% and 112 (52,1% respectively, but an increase in the incidence of OHL among female patients and those in the fifth decade of life was observed. Tobacco smoking was the most frequent harmful habit reported by 114 (68% patients. OHL occurred mostly in patients with CD4 counts between 200 and 500 cells/mm3 35 (55.5%. The lower incidence of OHL was found among patients using at least one non-nucleoside reverse transcriptase inhibitor (NNRTI. OHL is related to CD4 count, use of ARVT and tobacco smoking and is also more prevalent in men in the fourth decade of life. These characteristics were recognized in absolute values, but when verifying the behavior over the years we noticed that the incidence of OHL is decreasing and its epidemiological characteristics changing.

  17. microRNA-215异常激活抑制Dicer1促进肝癌细胞迁移和转化

    Institute of Scientific and Technical Information of China (English)

    李文娟; 韩翰; 孙丹; 沈洪星; 李友军; 张进祥

    2015-01-01

    microRNA异常表达促进癌症的发生发展.本研究通过microRNA表达谱分析2个肝癌细胞和2个正常细胞microRNA的表达,寻找与肝癌相关的microRNA,发现microRNA-215在肝癌细胞中高表达,qRT—PCR验证microRNA-215在肝癌细胞呈显著高表达.进一步研究发现,microRNA-215直接靶向Dicerl基因的3'UTR并抑制Dicerl蛋白表达,Dicerl是microRNA加工成熟过程中必需的蛋白.过表达microRNA-215抑制Dicerl从而促进肝癌细胞迁移和转化,而抑制microRNA-215表达起相反作用.Dicerl抑制后,许多抑癌microRNA表达被抑制,从而促进迁移和转化.相对于癌旁组织,Dicerl在肝癌组织呈明显低表达.本研究揭示,microRNA-215异常活化并抑制Dicerl表达与肝癌发展相关.

  18. Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer.

    Science.gov (United States)

    Ye, Mingxiang; Zhang, Jin; Zhang, Jiän; Miao, Qing; Yao, Libo; Zhang, Jian

    2015-02-01

    Curcumin has attracted increasing interest as an anti-cancer drug for decades. The mechanisms of action involve multiple cancer-related signaling pathways. Recent studies highlighted curcumin has epigenetic regulatory effects on miRNA in cancers. In the present study, we demonstrated the proapoptotic effects of curcumin in vitro and in vivo. miRNA microarray and qPCR indicated that miR-192-5p and miR-215 were the most responsive miRNAs upon curcumin treatment in H460 and A427 cells. Functional studies showed miR-192-5p/215 were putative tumor suppressors in non-small cell lung cancer. Curcumin also promoted miR-192-5p/215 expressions in A549 cells (p53 wild type) but not in H1299 cells (p53-null). Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells. Conversely, ectopic expression of exogenous wild-type but not R273H mutant p53 in the p53-null H1299 cells enabled miR-192-5p/215 response to curcumin treatment. The proapoptotic effects of curcumin also depended on miR-192-5p/215 induction, and antagonizing miR-192-5p/215 expression attenuated curcumin-induced apoptosis in H460, A427 and A549 cells, but not in H1299 cells. Finally, X-linked inhibitor of apoptosis (XIAP) is proved to be a novel transcriptional target of miR-192-5p/215. Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer.

  19. Growth, physicochemical properties, and morphogenesis of Chinese wild-type PRV Fa and its gene-deleted mutant strain PRV SA215

    Directory of Open Access Journals (Sweden)

    Tang Shanhu

    2011-06-01

    Full Text Available Abstract Background PRV Fa is common in China and causes most of the pseudorabies in the pig industry. A PRV SA215 strain with deleted gE, gI, and TK genes was constructed to develop a commercial attenuated live vaccine. However, the physicochemical properties, growth pattern, penetration kinetics, and morphogenesis of the PRV SA215 and its parental PRV Fa strain are unclear. Results A series of experiments were conducted to characterize both strains and provide more information. PRV Fa and PRV SA215 were found to have similar penetration patterns, with about 5 min half-time of penetration. The SA215 strain exhibited a slight delay in entry compared with PRV Fa. In the one-step growth test, the titers of the SA215 strain were first detected at 8 h, rapidly increased, and peaked at 12 h. A plateau was formed between 12-36 h of culturing. PRV SA215 showed delayed replication and approximately 10-30-fold lower titers during 0-16 h of culturing compared with the PRV-Fa strain. After 16 h, the PRV Fa titers dramatically decreased, whereas those of PRV SA215 were prolonged to 36 h and reached a titer value equal to that of PRV Fa and then decreased. Both strains were sensitive to both heat and acid-alkali treatments; however, PRV Fa was relatively more stable to heat treatment than PRV SA215. Both strains could propagate in the cultures with pH values from 5.0 to 9.0. Cultures with pH below 3.0 or above 11.0 were fatal to both strains. Both strains had considerable resistance to freeze-thawing treatments. Morphogenetic investigations showed that typical phases in the maturation pathway were observed in the PRV Fa-infected PK15 cells, whereas secondary envelopment was not observed in the PRV SA215 strain. Instead, capsid aggregations with concomitants of electrodense materials were observed. Conclusions These results suggest that PRV SA215 is a promising strain for vaccine development

  20. Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Fabao [Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China); Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China); You, Xiaona [Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China); Chi, Xiumei [Department of Hepatology, The First Hospital, Jilin University, Changchun 130021 (China); Wang, Tao [Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China); Ye, Lihong [Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China); Niu, Junqi, E-mail: junqiniu@yahoo.com.cn [Department of Hepatology, The First Hospital, Jilin University, Changchun 130021 (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China)

    2014-02-07

    Highlights: • Relative to wild type HBx, HBX mutant HBxΔ127 strongly enhances cell proliferation. • Relative to wild type HBx, HBxΔ127 remarkably up-regulates miR-215 in hepatoma cells. • HBxΔ127-elevated miR-215 promotes cell proliferation via targeting PTPRT mRNA. - Abstract: The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). Relative to wild type HBx, HBxΔ127 strongly enhanced cell proliferation and migration in HCC. In this study, we aim to explore the mechanism of HBxΔ127 in promotion of proliferation of hepatoma cells. Our data showed that both wild type HBx and HBxΔ127 could increase the expression of miR-215 in hepatoma HepG2 and H7402 cells. However, HBxΔ127 was able to significantly increase miR-215 expression relative to wild type HBx in the cells. We identified that protein tyrosine phosphatase, receptor type T (PTPRT) was one of the target genes of miR-215 through targeting 3′UTR of PTPRT mRNA. In function, miR-215 was able to promote the proliferation of hepatoma cells. Meanwhile anti-miR-215 could partially abolish the enhancement of cell proliferation mediated by HBxΔ127 in vitro. Knockdown of PTPRT by siRNA could distinctly suppress the decrease of cell proliferation mediated by anti-miR-215 in HepG2-XΔ127/H7402-XΔ127 cells. Moreover, we found that anti-miR-215 remarkably inhibited the tumor growth of hepatoma cells in nude mice. Collectively, relative to wild type HBx, HBxΔ127 strongly enhances proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Our finding provides new insights into the mechanism of HBx mutant HBxΔ127 in promotion of proliferation of hepatoma cells.

  1. 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.

    Science.gov (United States)

    Liu, Xiaojing; Zhang, Suhong; Arora, Jasbir S; Snyder, Nathaniel W; Shah, Sumit J; Blair, Ian A

    2011-12-19

    Previously, we established that 11(R)-hydroxy-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (HETE) was a significant cyclooxygenase (COX)-2-derived arachidonic acid (AA) metabolite in epithelial cells. Stable isotope dilution chiral liquid chromatography (LC)-electron capture atmospheric pressure chemical ionization (ECAPCI)/mass spectrometry (MS) was used to quantify COX-2-derived eicosanoids in the human colorectal adenocarcinoma (LoVo) epithelial cell line, which expresses both COX-2 and 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 11(R)-HETE secretion reached peak concentrations within minutes after AA addition before rapidly diminishing, suggesting further metabolism had occurred. Surprisingly, recombinant 15-PGDH, which is normally specific for oxidation of eicosanoid 15(S)-hydroxyl groups, was found to convert 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE). Furthermore, LoVo cell lysates converted 11(R)-HETE to 11-oxo-ETE and inhibition of 15-PGDH with 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid (CAY10397) (50 μM) significantly suppressed endogenous 11-oxo-ETE production with a corresponding increase in 11(R)-HETE. These data confirmed COX-2 and 15-PGDH as enzymes responsible for 11-oxo-ETE biosynthesis. Finally, addition of AA to the LoVo cells resulted in rapid secretion of 11-oxo-ETE into the media, reaching peak levels within 20 min of starting the incubation. This was followed by a sharp decrease in 11-oxo-ETE levels. Glutathione (GSH) S-transferase (GST) was found to metabolize 11-oxo-ETE to the 11-oxo-ETE-GSH (OEG)-adduct in LoVo cells, as confirmed by LC-MS/MS analysis. Bromodeoxyuridine (BrdU)-based cell proliferation assays in human umbilical vein endothelial cells (HUVECs) revealed that the half-maximal inhibitory concentration (IC(50)) of 11-oxo-ETE for inhibition of HUVEC proliferation was 2.1 μM. These results show that 11-oxo-ETE is a novel COX-2/15-PGDH-derived eicosanoid, which inhibits endothelial

  2. Regulation of FSHβ induction in LβT2 cells by BMP2 and an Activin A/BMP2 chimera, AB215.

    Science.gov (United States)

    Jung, Jae Woo; Ahn, Chihoon; Shim, Sun Young; Gray, Peter C; Kwiatkowski, Witek; Choe, Senyon

    2014-10-01

    Activins and bone morphogenetic proteins (BMPs) share activin type 2 signaling receptors but utilize different type 1 receptors and Smads. We designed AB215, a potent BMP2-like Activin A/BMP2 chimera incorporating the high-affinity type 2 receptor-binding epitope of Activin A. In this study, we compare the signaling properties of AB215 and BMP2 in HEK293T cells and gonadotroph LβT2 cells in which Activin A and BMP2 synergistically induce FSHβ. In HEK293T cells, AB215 is more potent than BMP2 and competitively blocks Activin A signaling, while BMP2 has a partial blocking activity. Activin A signaling is insensitive to BMP pathway antagonism in HEK293T cells but is strongly inhibited by constitutively active (CA) BMP type 1 receptors. By contrast, the potencies of AB215 and BMP2 are indistinguishable in LβT2 cells and although AB215 blocks Activin A signaling, BMP2 has no inhibitory effect. Unlike HEK293T, Activin A signaling is strongly inhibited by BMP pathway antagonism in LβT2 cells but is largely unaffected by CA BMP type 1 receptors. BMP2 increases phospho-Smad3 levels in LβT2 cells, in both the absence and the presence of Activin A treatment, and augments Activin A-induced FSHβ. AB215 has the opposite effect and sharply decreases basal phospho-Smad3 levels and blocks Smad2 phosphorylation and FSHβ induction resulting from Activin A treatment. These findings together demonstrate that while AB215 activates the BMP pathway, it has opposing effects to those of BMP2 on FSHβ induction in LβT2 cells apparently due to its ability to block Activin A signaling.

  3. Cámara CCD Directa con el Telescopio de 2.15 m del CASLEO: algunos diagnósticos

    Science.gov (United States)

    Cellone, S. A.

    Se efectuaron algunas pruebas con la cámara CCD (+ Reductor Focal) instalada en el foco Cassegrain del Telescopio de 2.15 m del Complejo Astronómico El Leoncito (CASLEO). Las conclusiones más significativas son: Los tiempos de exposición efectivos difieren de los nominales en una fracción apreciable de segundo. En exposiciones de menos de 3 segundos, la iluminación no es pareja en todo el detector. En consecuencia, se recomiendan los pasos a seguir por los astrónomos tanto durante la observación como en la reducción de sus datos.

  4. MTE215-12-4型模块式动力液压平板运输车

    Institute of Scientific and Technical Information of China (English)

    杨卓林; 詹立勤; 贾强乐; 张少军

    2011-01-01

    Model MTE215-12-4 modular type mobile hydraulic flat-bed trailer is mainly used for ships, aviation, electric power plant, ocean platform and other areas of large components, therefore, design of the whole vehicle has fully considered big-ticket transport vehicles and their mechanical structure characteristics with integration qf advanced computer technology, microelectronics technology, hydraulic pressure technology, fuzzy control technology, wireless communication technology, and cooperate with hydraulic drive and control system, thus realizing intelligent remote operation. The text introduces features of the performance and its construction.%MTE215-12-4型模块式动力液压平板运输车主要用于船舶、航空、电力、海洋平台等领域的大型构件运输,整车设计充分考虑了大件运输车辆的机械结构特点并集成了先进的计算机技术、微电子技术、液压技术、模糊控制技术、无线通信技术,并配合液压驱动和控制系统,实现了智能化遥控操作.介绍其性能特点及结构组成.

  5. Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain

    Energy Technology Data Exchange (ETDEWEB)

    Ribiero, Ruy M [Los Alamos National Laboratory

    2009-01-01

    To investigate the impact of humoral immunity on SIV replication, 11 rhesus macaques (RMs) were inoculated with the neutralization-sensitive strain SIVsmmD215. Seven RMs were treated every three weeks, with 50 mglkg of an anti-CD20 antibody (Rituxan, gift from Genentech) starting from day -7 p.i., as follows: four RMs were treated for two months, and three were treated for five months. The remaining four RMs were used as controls. Three RMs were completely depleted of CD20 cells. Four RMs only partially depleted CD20 cells in the LNs and intestine. The efficacy of tissue CD20 depletion predicted the ablation of antibody production, with SIVsmm seroconversion being delayed in the animals with complete tissue CD20 depletion, and neutralizing antibody production being significantly delayed and at low levels in all CD20-depleted RMs. There was no significant difference in acute or chronic VLs between CD20-depleted RMs and control monkeys, with a tendency for lower set-point VLs in CD20-depleted RMs. At 6 weeks p.i., cellular immune responses were significantly stronger in CD20 depleted RMs than in controls. After two years p.i., there was no significant difference in survival between CD20-depleted and control RMs. We concluded that CD20 depletion plays no significant role in the control of SIV replication or disease progression in SIVsmmD215-infected RMs.

  6. MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes

    Science.gov (United States)

    Yan, Li; Cao, Rui; Liu, Yuanbo; Wang, Lianzhao; Pan, Bo; Lv, Xiaoyan; Jiao, Hu; Zhuang, Qiang; Sun, Xuejian; Xiao, Ran

    2016-09-01

    Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNAs microarray analysis we found mir-21-5p was significantly up-regulated in keloid epidermis. To investigate the role of miR-21-5p in keloid pathogenesis, we transfected miR-21-5p mimic or inhibitor in keloid keratinocytes and examined the abilities of cell proliferation, apoptosis, migration and invasion, the expressions of EMT-related markers vimentin and E-cadherin and stem-like cells-associated markers CD44 and ALDH1, and the involvement of PTEN and the signaling of AKT and ERK. Our results demonstrated that up-regulation or knockdown of miR-21-5p significantly increased or decreased the migration, invasion and sphere-forming abilities of keloid keratinocytes, and the phenotype of EMT and cells stemness were enhanced or reduced as well. Furthermore, PTEN and p-AKT were shown to participate in the regulation of miR-21-5p on EMT phenotypes and stemness signatures of keloid keratinocytes, which might account for the invasion and recurrence of keloids. This molecular mechanism of miR-21-5p on keloid keratinocytes linked EMT with cells stemness and implicated novel therapeutic targets for keloids.

  7. “Remotion” Total Wrist Arthroplasty: Preliminary Results of a Prospective International Multicenter Study of 215 Cases

    DEFF Research Database (Denmark)

    Herzberg, Guillaume; Boeckstyns, Michel Ernest Henri; Sorensen, Allan Ibsen;

    2012-01-01

    preoperative and postoperative reports of "ReMotion" TWA at regular intervals. The cases of 7 centers with more than 15 inclusions were considered for this article. A total of 215 wrists were included. In the rheumatoid arthritis (RA; 129 wrists) and nonrheumatoid arthritis (non-RA; 86 wrists) groups......This study reports the current results of an international multicenter study of one last generation total wrist arthroplasty (TWA) ("ReMotion," Small Bone Innovation, Morristown, PA). The two first authors (G.H. and M.B.) built a Web-based prospective database including clinical and radiological...... with the previous generation TWA. The level of evidence for this study is IV....

  8. 48 CFR 52.215-21 - Requirements for Certified Cost or Pricing Data and Data Other Than Certified Cost or Pricing...

    Science.gov (United States)

    2010-10-01

    ... Contractor shall submit a Certificate of Current Cost or Pricing Data, as prescribed by FAR 15.406-2. (End of... Cost or Pricing Data and Data Other Than Certified Cost or Pricing Data-Modifications. 52.215-21... Requirements for Certified Cost or Pricing Data and Data Other Than Certified Cost or Pricing...

  9. 47 CFR 68.215 - Installation of other than “fully protected” system premises wiring that serves more than four...

    Science.gov (United States)

    2010-10-01

    ... TERMINAL EQUIPMENT TO THE TELEPHONE NETWORK Terminal Equipment Approval Procedures § 68.215 Installation of... telephone network interface(s). Fully-protected premises wiring shall be used to connect equipment entities to the public switched telephone network interface unless the provider of wireline...

  10. Patch tests and screening for new allergen in 215 cases with contact dermatitis%215例接触性皮炎斑贴试验结果及新致敏原筛查

    Institute of Scientific and Technical Information of China (English)

    郁辉; 侯占英; 徐浪锋; 陈珩; 刘芳

    2010-01-01

    Patch tests were performed in 215 cases with contact dermatitis and 59 cases with noncontact dermatitis who visited the clinic of Xili Hospital, Shenzhen.Results showed that top four allergen for them were 0.1% Merthiolate, 5% nickel sulfate, 7% aromatic compounds and 1% formaldehyde in sequence.There was significant difference in occurrence of dermatitis at the hands, trunk, extremities,face, and periumbilicus caused by these four kinds of allergen (P <0.01 ), with 0.1% Merthiolate mainly causing dermatitis at the face, hands, trunk and extremities, 5% nickel sulfate causing dermatitis at the periumbilicus, trunk and extremities, 7% aromatic compounds causing dermatitis at the hands, trunk,extremities and face, whereas 1% formaldehyde mainly causing facial dermatitis.Concentration of pentyl acetate and rosin spirit used for patch tests should be 20 % and 25 %, respectively.%对215例门诊接触性皮炎及59例非接触性皮炎患者做斑贴试验.结果列前四位的致敏原分别是0.1%硫柳汞、5%硫酸镍、7%芳香混合物、1%甲醛.这4种致敏原在手部、躯干四肢、面部和脐周的患病率差异有统计学意义(P<0.01),提示0.1%硫柳汞主要引起面部、手部、躯干及四肢皮炎,5%硫酸镍主要引起脐周和躯干及四肢皮炎,7%芳香混合物主要引起手部、躯干及四肢、面部皮炎,1%甲醛主要引起面部皮炎;乙酸戊酯、松香水的斑贴试验浓度分别为20%、25%.

  11. 215例垂体腺瘤术后患者腺垂体功能评估及替代状况分析%Outcome of postoperative hypopituitarism and hormone replacement situation in 215 patients with pituitary adenoma

    Institute of Scientific and Technical Information of China (English)

    曾梅芳; 赵曜; 王镛斐; 李益明; 蒋翠萍; 叶红英; 张烁; 何敏; 杨叶虹; 鹿斌; 胡仁明; 李士其

    2012-01-01

    Objective To investigate the outcome of postoperative hypopituitarism and hormone replacement in patients with pituitary adenoma,and to analyze the potential factors related to postoperative hypopituitarism.Methods A total of 215 postoperative patients with pituitary adenoma were analyzed.Pituitary functions( including gonadal,thyroid,and adrenal axes ) were asessed by strict criteria.Data of surgery history and hormone replacement situation were collected for statistical analysis.Results The prevalence of hypopituitarism was 54.0%,including 36.7% hypogonadism,32.6% hypothyroidism,and 28.4% hypoadrenalism.Replacements of gonadal steroid,glucocorticoid,and thyroxine were carried out in 25.6%,84.3%,and 80.6% of the cases,respectively.Univariate analysis showed that male sex and large tumor were related to hypopituitarism. Conclusion After pituitary adenomectomy,approximately half of the patients present anterior pituitary dysfunction,while quite a number of them have not been treated appropriately.%目的 了解垂体腺瘤术后患者腺垂体功能减退及其替代治疗情况,寻找与其功能减退可能相关的因素.方法 对215例就诊于华山医院内分泌科的垂体腺瘤术后患者进行垂体性腺轴、甲状腺轴、肾上腺皮质轴功能评估,收集手术病史、替代状况等资料进行统计分析.结果 存在腺垂体功能减退的患者占54.0%,其中性腺、甲状腺、肾上腺皮质功能减退的比例分别为36.7%、32.6%、28.4%,相应激素替代为25.6%、84.3%、80.6%.单因素分析显示男性和肿瘤较大与腺垂体功能减退相关.结论 内分泌科就诊的垂体腺瘤术后患者半数存在腺垂体功能减退,而且有相当一部分功能减退的患者未能得到恰当的替代治疗.

  12. Isolation of Actinium from Neutron-irradiated Thorium-I

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Isolation of Actinium from Neutron-irradiated Thorium-I¥YangWeifan;YuanShuanggui;MuWantong;ZhangXueqian;LiZhongweiandZhaoLili...

  13. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  14. Characteristics of Distribution of 215 Acinetobacter Pneumonia and Drug Susceptibility Analysis in Respiratory Ward%215株致肺炎不动杆菌的分布特点与药敏分析

    Institute of Scientific and Technical Information of China (English)

    周煦; 李文朴; 李榜龙

    2009-01-01

    [Objective] To investigate the distribution of Acinetobacter pneumonia,drug susceptibility and its relationship with diseases of pneumonia. [Methods] All the Acinetobacter isolated from sputum from January 2000 to December 2007 were analyzed retrospectively. [Results] All 215 Acinetobacter isolates were collected, which contained 132 baumanii(61.4%), accounting to 14.3% of the total of sputum culture positive and 16.4% of negative bacilli. The number of Acinetobacter isolated from patients with lung underlying diseases was 177(82.3%). The result of drug susceptibility suggested that sensitive antibacterials were Cefoperazone/ sulbactam ,Meropenem,Cefepime and Levofloxacin, and resistant antibacterials were Aztreonam, Mezlocillin and Amphemycin. The drug susceptibility between 132 baumanii and 83 other Acinetobacter had significant difference(P<0.05). The results of Acinetobacter strain sensitivity whether or not isolated from the patients using respirator had significant differences(P<0.05). [Conclusion] Acinetobacter is the fundamental composition of lower respiratory tract bacterial infection,and Acinetobacter baumanii is the main. The drug susceptibility is obviously different between baumanii and other Acinetobacter. Acinetobacter is resistant to antibiotics widely and also related to respirator and lung underlying diseases. The characteristics of Acinetobacter infection is prone to patients with lung underlying diseases and is not only the main pathogenic bacteria of hospital infection,but also can cause the patients with lung underlying diseases to suffer from the community acquired pneumonia.%[目的]了解本院住院患者肺炎不动杆菌的分布、与疾病的关系及药物敏感情况.[方法]对本院2000年1月至2007年12月本院肺炎住院患者痰或支气管分泌物标本不动杆菌培养阳性结果结合病历进行回顾性统计分析.[结果]共分离出不动杆菌215株,占总分离菌株的14.3%(215/1503),革兰阴性杆菌的16.4%(215

  15. Human Immunodeficiency Virus Type 1 Superinfection Was Not Detected following 215 Years of Injection Drug User Exposure

    Science.gov (United States)

    Tsui, Rose; Herring, Belinda L.; Barbour, Jason D.; Grant, Robert M.; Bacchetti, Peter; Kral, Alex; Edlin, Brian R.; Delwart, Eric L.

    2004-01-01

    Evidence for human immunodeficiency virus type 1 (HIV-1) superinfection was sought among 37 HIV-1-positive street-recruited active injection drug users (IDUs) from the San Francisco Bay area. HIV-1 sequences from pairs of samples collected 1 to 12 years apart, spanning a total of 215 years of exposure, were generated at p17 gag, the V3-V5 region of env, and/or the first exon of tat and phylogenetically analyzed. No evidence of HIV-1 superinfection was detected in which a highly divergent HIV-1 variant emerged at a frequency >20% of the serum viral quasispecies. Based on the reported risk behavior of the IDUs and the HIV-1 incidence in uninfected subjects in the same cohort, a total of 3.4 new infections would have been expected if existing infection conferred no protection from superinfection. Adjusted for risk behaviors, the estimated relative risk of superinfection compared with initial infection was therefore 0.0 (95% confidence interval, 0.00, 0.79; P = 0.02), indicating that existing infection conferred a statistically significant level of protection against superinfection with an HIV-1 strain of the same subtype, which was between 21 and 100%. PMID:14671091

  16. Words in melody: an H(2)15O PET study of brain activation during singing and speaking.

    Science.gov (United States)

    Jeffries, K J; Fritz, J B; Braun, A R

    2003-04-15

    We used H(2)15O PET to characterize the interaction of words and melody by comparing brain activity measured while subjects spoke or sang the words to a familiar song. Relative increases in activity during speaking vs singing were observed in the left hemisphere, in classical perisylvian language areas including the posterior superior temporal gyrus, supramarginal gyrus, and frontal operculum, as well as in Rolandic cortices and putamen. Relative increases in activity during singing were observed in the right hemisphere: these were maximal in the right anterior superior temporal gyrus and contiguous portions of the insula; relative increases associated with singing were also detected in the right anterior middle temporal gyrus and superior temporal sulcus, medial and dorsolateral prefrontal cortices, mesial temporal cortices and cerebellum, as well as in Rolandic cortices and nucleus accumbens. These results indicate that the production of words in song is associated with activation of regions within right hemisphere areas that are not mirror-image homologues of left hemisphere perisylvian language areas, and suggest that multiple neural networks may be involved in different aspects of singing. Right hemisphere mechanisms may support the fluency-evoking effects of singing in neurological disorders such as stuttering or aphasia.

  17. The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Graham S.T.; Seymour, Lauren V. [Molecular and Cellular Biology, University of Guelph, Guelph, Ontario (Canada); Boggs, Joan M. [Molecular Structure and Function, Research Institute, Hospital for Sick Children, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario (Canada); Harauz, George, E-mail: gharauz@uoguelph.ca [Molecular and Cellular Biology, University of Guelph, Guelph, Ontario (Canada)

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer Full-length 21.5-kDa MBP isoform is translocated to the nucleus. Black-Right-Pointing-Pointer We hypothesized that the exon-II-encoded sequence contained the NLS. Black-Right-Pointing-Pointer We mutated this sequence in RFP-tagged constructs and transfected N19-cells. Black-Right-Pointing-Pointer Abolition of two key positively-charged residues resulted in loss of nuclear-trafficking. Black-Right-Pointing-Pointer The 21.5-kDa isoform of classic MBP contains a non-traditional PY-NLS. -- Abstract: The predominant 18.5-kDa classic myelin basic protein (MBP) is mainly responsible for compaction of the myelin sheath in the central nervous system, but is multifunctional, having numerous interactions with Ca{sup 2+}-calmodulin, actin, tubulin, and SH3-domains, and can tether these proteins to a lipid membrane in vitro. The full-length 21.5-kDa MBP isoform has an additional 26 residues encoded by exon-II of the classic gene, which causes it to be trafficked to the nucleus of oligodendrocytes (OLGs). We have performed site-directed mutagenesis of selected residues within this segment in red fluorescent protein (RFP)-tagged constructs, which were then transfected into the immortalized N19-OLG cell line to view protein localization using epifluorescence microscopy. We found that 21.5-kDa MBP contains two non-traditional PY-nuclear-localization signals, and that arginine and lysine residues within these motifs were involved in subcellular trafficking of this protein to the nucleus, where it may have functional roles during myelinogenesis.

  18. pHluorin enables insights into the transport mechanism of antiporter Mdr1: R215 is critical for drug/H+ antiport.

    Science.gov (United States)

    Redhu, Archana Kumari; Khandelwal, Nitesh Kumar; Banerjee, Atanu; Moreno, Alexis; Falson, Pierre; Prasad, Rajendra

    2016-10-01

    Multidrug resistance 1 (MDR1) is a member of the major facilitator superfamily that contributes to MDR of Candida albicans This antiporter belongs to the drug/H(+) antiporter 1 family, pairing the downhill gradient of protons to drug extrusion. Hence, drug efflux from cytosol to extracellular space and the parallel import of H(+) towards cytosol are inextricably linked processes. For monitoring the drug/H(+) antiporter activity of Mdr1p, we developed a new system, exploiting a GFP variant pHluorin, which changes its fluorescence properties with pH. This enabled us to measure the cytosolic pH correlated to drug efflux. Since protonation of charged residues is a key step in proton movement, we explored the role of all charged residues of the 12 transmembrane segments (TMSs) of Mdr1p in drug/H(+) transport by mutational analysis. This revealed that the conserved residue R(215), positioned close to the C-terminal end of TMS-4, is critical for drug/H(+) antiport, allowing protonation over a range of pH, in contrast with its H(215) or K(215) variants that failed to transport drugs at basic pH. Mutation of other residues of TMS-4 highlights the role of this TMS in drug transport, as confirmed by in silico modelling of Mdr1p and docking of drugs. The model points to the importance of R(215) in proton transport, suggesting that it may adopt two main conformations, one oriented towards the extracellular face and the other towards the centre of Mdr1p. Together, our results not only establish a new system for monitoring drug/H(+) transport, but also unveil a positively charged residue critical to Mdr1p function.

  19. Literature and data review and compilation. Final topical report. [Mathematical codes describing fluidized bed gasifiers, CHEMFLUB and FLAG; 215 references

    Energy Technology Data Exchange (ETDEWEB)

    Matulevicius, E.S.; Golan, L.P.; Heard, W.B.; Bhagat, P.M.; Segev, A.

    1984-06-01

    The purpose of this review is to provide a database for the evaluation and validation of mathematical codes describing fluidized bed gasifiers. This review was prompted by the need to evaluate two numerical codes, CHEMFLUB and FLAG, developed under Department of Energy sponsorship. Because of fundamental nature of the codes, they may possibly be used as a potential method for minimizing the cost and time required to develop and commercialize fluidized bed gasifiers. In order to have the confidence that these codes can accurately predict fluidization and gasification phenonmena, a logical and systematic comparison of the codes against key correlations is required. This review contains the necessary data and correlations for this evaluation. Previously developed computer models of fluidized bed gasifiers are empirical in nature. Hence, they are useful only in regions where the assumptions are valid. On the other hand, CHEMFLUB and FLAG begin with a fundamental description of the fluid mechanics, chemistry and heat transfer relationships. Because of this, there is promise that these models could be used in areas where experimental information is not readily available, to address issues of scale-up, and to examine transient phenomena often associated with operating and safety issues. In order to have confidence that the models are able to predict gasifier behavior, it is necessary that key physical parameters be efficiently and accurately calculated. This review divides the database required into two major areas, gasification kinetics, and fluidization behavior. The review is not intended to critically analyze all the information in the literature. Rather, it is a selective review of the literature, tailored to provide the necessary data to evaluate and validate the codes. 215 references.

  20. Optical imaging and high spatial resolution 21 cm H I observations of the peculiar galaxy NGC 2782 (Arp 215)

    Science.gov (United States)

    Smith, Beverly J.

    1994-01-01

    We have used the Very Large Array (VLA) B and C Arrays to make 21 cm H I observations of the peculiar galaxy NGC 2782 (Arp 215). These observations are complementary to previously published D Array VLA data, which revealed the presence of a long (5 min to 54 kpc) H I plume near the western side of this galaxy. We have also obtained BVRI H alpha images of the main body of this galaxy using the McDonald Observatory 30 inch telescope. The optical images of this galaxy show a strong stellar tail extending to the east, opposite the H I plume. Within the disk of NGC 2782, unsharp masking of the optical images at all 4 broadband wavelengths reveals three bright 'ripples', separated by approximately 15 sec. The light profiles across these ripples are symmetric, without a sharp outer edge. H alpha is strong at the starburst nucleus and along the northern and western sections of the inner ripple. The new higher resolution H I data show that the atomic gas is very clumpy. We have identified ten H I clumps in the long western plume, with H I masses of approximately 10(exp 8) solar mass, similar to those of dwarf galaxies, and column densities of approximately 10(exp 21) cm(exp -2) over surface areas of approximately 10 kpc(exp 2). No CO (1-0) emission has been detected from this plume, suggesting that it is material stripped from the outer edge of a disk galaxy. The H alpha peaks, in contrast, are generally not coincident with H I peaks. No H I is seen at the tip of the eastern extension. The H I distribution near this structure is ring-like rather than tail-like as in the optical data. We have detected redshifted H I absorption toward the central continuum source, indicating gas infall into the nuclear region. Using a restricted 3-body dynamical model, we have successfully reproduced the basic properties of NGC 2782 with an off-center collision between two galaxies, where a lower mass disk companion (M(sub 2)/M(sub 1) approximately 0.25) collides almost head-on with a larger

  1. CFTR depletion results in changes in fatty acid composition and promotes lipogenesis in intestinal Caco 2/15 cells.

    Directory of Open Access Journals (Sweden)

    Geneviève Mailhot

    Full Text Available BACKGROUND: Abnormal fatty acid composition (FA in plasma and tissue lipids frequently occurs in homozygous and even in heterozygous carriers of cystic fibrosis transmembrane conductance regulator (CFTR mutations. The mechanism(s underlying these abnormalities remained, however, poorly understood despite the potentially CFTR contributing role. METHODOLOGY/PRINCIPAL FINDINGS: The aim of the present study was to investigate the impact of CFTR depletion on FA uptake, composition and metabolism using the intestinal Caco-2/15 cell line. shRNA-mediated cftr gene silencing induced qualitative and quantitative modifications in FA composition in differentiated enterocytes as determined by gas-liquid chromatography. With the cftr gene disruption, there was a 1,5 fold increase in the total FA amount, largely attributable to monounsaturated and saturated FA compared to controls. The activity of delta-7 desaturase, estimated by the 16:1(n-7/16:0, was significantly higher in knockdown cells and consistent with the striking elevation of the n-7 FA family. When incubated with [14C]-oleic acid, CFTR-depleted cells were capable of quick incorporation and export to the medium concomitantly with the high protein expression of L-FABP known to promote intracellular FA trafficking. Accordingly, lipoprotein vehicles (CM, VLDL, LDL and HDL, isolated from CFTR knockdown cells, exhibited higher levels of radiolabeled FA. Moreover, in the presence of [14C]-acetate, knockdown cells exhibited enhanced secretion of newly synthesized phospholipids, triglycerides, cholesteryl esters and free FA, thereby suggesting a stimulation of the lipogenic pathway. Conformably, gene expression of SREBP-1c, a key lipogenic transcription factor, was increased while protein expression of the phosphorylated and inactive form of acetylCoA carboxylase was reduced, confirming lipogenesis induction. Finally, CFTR-depleted cells exhibited lower gene expression of transcription factors (PPARalpha

  2. Impact of heterozygous c.657-661del, p.I171V and p.R215W mutations in NBN on nibrin functions.

    Science.gov (United States)

    Dzikiewicz-Krawczyk, Agnieszka; Mosor, Maria; Januszkiewicz, Danuta; Nowak, Jerzy

    2012-05-01

    Nibrin, product of the NBN gene, together with MRE11 and RAD50 is involved in DNA double-strand breaks (DSBs) sensing and repair, induction of apoptosis and cell cycle control. Biallelic NBN mutations cause the Nijmegen breakage syndrome, a chromosomal instability disorder characterised by, among other things, radiosensitivity, immunodeficiency and an increased cancer risk. Several studies have shown an association of heterozygous c.657-661del, p.I171V and p.R215W mutations in the NBN gene with a variety of malignancies but the data are controversial. Little is known, however, whether and to what extent do these mutations in heterozygous state affect nibrin functions. We examined frequency of chromatid breaks, DSB repair, defects in S-phase checkpoint and radiosensitivity in X-ray-irradiated cells from control individuals, NBS patients and heterozygous carriers of the c.657-661del, p.I171V and p.R215W mutations. While cells homozygous for c.657-661del displayed a significantly increased number of chromatid breaks and residual γ-H2AX foci, as well as abrogation of the intra-S-phase checkpoint following irradiation, which resulted in increased radiosensitivity, cells with heterozygous c.657-661del, p.I171V and p.R215W mutations behaved similarly to control cells. Significant differences in the frequency of spontaneous and ionising radiation-induced chromatid breaks and the level of persistent γ-H2AX foci were observed when comparing control and mutant cells heterozygous for c.657-661del. However, it is still possible that heterozygous NBN mutations may contribute to cancer development.

  3. A retrospective analysis of 215 Uyghur patients with cleft lip and palate%215例维吾尔族唇腭裂患者的回顾性分析

    Institute of Scientific and Technical Information of China (English)

    多力昆·吾甫尔; 木合塔尔·霍加; 米热古丽·吾马尔; 李军; 闫广鹏; 卡米力·买买提明

    2013-01-01

    目的通过回顾性分析本院维吾尔族唇腭裂患儿的临床资料,为唇腭裂的预防提供临床资料。方法对2009年1月-2012年8月间新疆维吾尔自治区人民医院口腔颌面外科手术治疗的215例维吾尔族唇腭裂住院患者进行回顾性分析。结果本组病例中单侧唇裂18例、唇裂伴腭裂115例、单纯腭裂80例,单侧唇腭裂多于双侧,所有患者中出生于7-9月者均少于其他季度,患者父母多来自农村,母亲经历过危险因素的有55例。结论维吾尔族唇腭裂发病以唇裂合并腭裂居多,且以单侧发病多于双侧,男性多于女性。发生唇腭裂的病因除遗传因素外,出生家庭来源及胚胎的环境因素是其致病的危险因素。%Objective??This?study?aims?to?analyze?the?clinical?data?of?Uyghur?cases?of?cleft?lip?and?palate?to?provide?more information?on?the?prevention?for?this?malformation.??Methods??Two?hundred?and?twenty-five?cases?were?collected?from?patients?treated?in?the?People’s?Hospital?of?Xinjiang?Uyghur?Autonomous?Region,?from?January?2009?to?August?2012.?A?retrospective?clinic?study?was?carried?out.?Results??The?study?included?18?cases?of?cleft?lip,?115?cases?of?cleft?lip?with?cleft?palate,?and?80?cases?of?cleft?palate.?The?cases?of?unilateral?cleft?lip?with?or?without?palate?cases?were?higher?than?the?bilateral?cases.?In?all?cases,?patients?who?were?born?in?July?to?September?were?fewer?than?those?born?in?other?seasons.?Most?of?the?parents?of?the?patients?were?from?the?countryside.?Fifty-five?cases?had?mothers?underwent?danger?factor.?Conclusion???The?ratio?of?cleft?lip?with?cleft?palate?was?higher?than?the?other?types?in?Uyghur?patients.?The?cases?of?unilateral?cleft?lip?with?or?without?palate?cases?were?more?than?the?bilateral?cases,?and?males?were?more?than?females.?The?cleft?lip?and/or?palate?formation?may?be?related?with?multiple?genes?and?environmental?condition?in?the?early?stage?of?the?embryo.

  4. 应用Surrogate报告载体提高CRISPR/Cas9对TMEM215基因的打靶效率%Improving Gene Targeting Efficiency on TMEM215 Mediated by CRISPR/Cas9 by Using Surrogate Reporter

    Institute of Scientific and Technical Information of China (English)

    高晓彤; 付伟; 陈娟娟; 胡彬; 李丹慧; 黄斯勇; 李国辉; 张阳萍; 刘利

    2016-01-01

    目的:构建Surrogate报告载体,并利用Surrogate报告载体提高CRISPR/Cas9对HEK293T细胞TMEM215基因打靶效率.方法:构建针对人TMEM215的CRISPR/Cas9表达载体及相应Surrogate报告载体,两者共转HEK293T细胞,通过流式分析、T7EI检测、TA克隆测序等明确Surrogate报告载体对不同sgRNA打靶效率的检测及对基因修饰细胞的筛选富集作用.结果:流式分析结果表明,Surrogate报告载体成功检测出不同sgRNA的打靶效率,并筛选出高效率sgRNA;T7EI检测及TA克隆测序显示,外加嘌呤霉素抗性筛选时,Surrogate报告载体可有效富集基因修饰细胞.结论:成功构建Surrogate报告载体,并利用Surrogate报告载体提高CRISPR/Cas9对HEK293T细胞TME M215基因的打靶效率.

  5. Phase separation of myelin sheath in Triton X-114 solution: predominant localization of the 21.5-kDa isoform of myelin basic protein in the lipid raft-associated domain.

    Science.gov (United States)

    Uruse, Michihiro; Yamamoto, Masahiro; Sugawa, Makoto; Matsuura, Keiko; Sato, Yurie; Seiwa, Chika; Watanabe, Kenji; Aiso, Sadakazu; Asou, Hiroaki

    2014-04-01

    Myelin basic protein (MBP) isoforms in the myelin sheath are known to have distinct intracellular expression patterns, which are profoundly related to functional specificity. Determining the differential localization of MBP isoforms is therefore important for understanding their pathophysiological roles. In this study, we have developed a new method for phase separation of myelin. The non-ionic detergent Triton X-114 is used to solubilize myelin sheath which then undergoes phase separation to yield four fractions. The lipid raft-associated proteins and lipids in each fraction were analysed by immunoblotting and lipid analysis, respectively. The present method gives two lipid raft-enriched fractions, one of them was found to contain only lipid raft-associated galactocerebroside and cholesterol as the major lipids. The 21.5-kDa MBP isoforms (21.5 MBP), both unphosphorylated and phosphorylated, were exclusively contained in this fraction. Phosphorylated 21.5 MBP (21.5 pMBP) has been shown to specifically disappear from demyelinated loci. The present analytical method clearly indicated that disappearance of 21.5 pMBP corresponded to demyelination and its reappearance corresponded to prevention of demyelination. Demyelination was also associated with aging and was prevented by the myelin-protecting herbal medicine, Chinpi, a type of dried citrus peel.

  6. Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms.

    Science.gov (United States)

    Harauz, George; Boggs, Joan M

    2013-05-01

    The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in maturing oligodendrocytes. The 18.5-kDa isoform that predominates in adult myelin adheres the cytosolic surfaces of oligodendrocyte membranes together, and forms a two-dimensional molecular sieve restricting protein diffusion into compact myelin. However, this protein has additional roles including cytoskeletal assembly and membrane extension, binding to SH3-domains, participation in Fyn-mediated signaling pathways, sequestration of phosphoinositides, and maintenance of calcium homeostasis. Of the diverse post-translational modifications of this isoform, phosphorylation is the most dynamic, and modulates 18.5-kDa MBP's protein-membrane and protein-protein interactions, indicative of a rich repertoire of functions. In developing and mature myelin, phosphorylation can result in microdomain or even nuclear targeting of the protein, supporting the conclusion that 18.5-kDa MBP has significant roles beyond membrane adhesion. The full-length, early-developmental 21.5-kDa splice isoform is predominantly karyophilic due to a non-traditional P-Y nuclear localization signal, with effects such as promotion of oligodendrocyte proliferation. We discuss in vitro and recent in vivo evidence for multifunctionality of these classic basic proteins of myelin, and argue for a systematic evaluation of the temporal and spatial distributions of these protein isoforms, and their modified variants, during oligodendrocyte differentiation.

  7. Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.

    Science.gov (United States)

    Mahyous Saeyd, Salah Adam; Ewert-Krzemieniewska, Katarzyna; Liu, Boyin; Caspari, Thomas

    2014-07-01

    Although it is well established that Cdc2 kinase phosphorylates the DNA damage checkpoint protein Crb2(53BP1) in mitosis, the full impact of this modification is still unclear. The Tudor-BRCT domain protein Crb2 binds to modified histones at DNA lesions to mediate the activation of Chk1 by Rad3ATR kinase. We demonstrate here that fission yeast cells harbouring a hyperactive Cdc2CDK1 mutation (cdc2.1w) are specifically sensitive to the topoisomerase 1 inhibitor camptothecin (CPT) which breaks DNA replication forks. Unlike wild-type cells, which delay only briefly in CPT medium by activating Chk1 kinase, cdc2.1w cells bypass Chk1 to enter an extended cell-cycle arrest which depends on Cds1 kinase. Intriguingly, the ability to bypass Chk1 requires the mitotic Cdc2 phosphorylation site Crb2-T215. This implies that the presence of the mitotic phosphorylation at Crb2-T215 channels Rad3 activity towards Cds1 instead of Chk1 when forks break in S phase. We also provide evidence that hyperactive Cdc2.1w locks cells in a G1-like DNA repair mode which favours non-homologous end joining over interchromosomal recombination. Taken together, our data support a model such that elevated Cdc2 activity delays the transition of Crb2 from its G1 to its G2 mode by blocking Srs2 DNA helicase and Casein Kinase 1 (Hhp1).

  8. Aspergillus nidulans Dis1/XMAP215 protein AlpA localizes to spindle pole bodies and microtubule plus ends and contributes to growth directionality.

    Science.gov (United States)

    Enke, Cathrin; Zekert, Nadine; Veith, Daniel; Schaaf, Carolin; Konzack, Sven; Fischer, Reinhard

    2007-03-01

    The dynamics of cytoplasmic microtubules (MTs) is largely controlled by a protein complex at the MT plus end. In Schizosaccharomyces pombe and in filamentous fungi, MT plus end-associated proteins also determine growth directionality. We have characterized the Dis1/XMAP215 family protein AlpA from Aspergillus nidulans and show that it determines MT dynamics as well as hyphal morphology. Green fluorescent protein-tagged AlpA localized to MT-organizing centers (centrosomes) and to MT plus ends. The latter accumulation occurred independently of conventional kinesin or the Kip2-familiy kinesin KipA. alpA deletion strains were viable and only slightly temperature sensitive. Mitosis, nuclear migration, and nuclear positioning were not affected, but hyphae grew in curves rather than straight, which appeared to be an effect of reduced MT growth and dynamics.

  9. Synthesis and cytotoxic activities of novel 2-(1,5-bis(aryl penta-1,4-dien-2-yl benzo[d]thiazol derivatives

    Directory of Open Access Journals (Sweden)

    Betül Şahin

    2016-07-01

    Full Text Available Novel 2-(1,5-bis(arylpenta-1,4-dien-2-ylbenzo[d]thiazol (5a,b and 2-(((1S,2S,E-2-(benzo[d]thiazol-2-yl-1,5-di-arylpent-4-en-1-ylthioaniline (6a,b derivatives were obtained by addition of 2-aminobenzothiol to bis-benzylidinecyclobutanones (3a,b. The structures of the obtained compounds were characterized using the spectroscopic methods (NMR, IR, Elemental Analysis. Compounds 5a,b showed cytotoxic activities against C6 (Rat Brain tumor cells and HeLa (human uterus carcinoma in vitro. ©2016 ACG Publications. All rights reserved.

  10. Microbiological transformations. Part 48 : Enantioselective biohydrolysis of 2-, 3- and 4-pyridyloxirane at high substrate concentration using the Agrobacterium radiobacter AD1 epoxide hydrolase and its Tyr215Phe mutant

    NARCIS (Netherlands)

    Genzel, Y; Archelas, A; Lutje Spelberg, Jeffrey H.; Janssen, DB; Furstoss, R

    2001-01-01

    The epoxide hydrolase (EH) from Agrobacterium radiobacter AD1 wild type (ArWT) and its Tyr215Phe mutant were compared for the biocatalyzed hydrolytic kinetic resolution (BHKR) of 2-, 3- and 4-pyridyloxirane. The radioselectivity of the oxirane ring opening as well as the substrate concentration limi

  11. Stripe order and vibrational properties of La2NiO4+δ for δ=2/15 : Measurements and ab initio calculations

    Science.gov (United States)

    Homes, C. C.; Tranquada, J. M.; Buttrey, D. J.

    2007-01-01

    The optical properties of the static charge- and stripe-ordered material La2NiO4+δ for δ=(2)/(15) have been measured over a wide frequency and temperature range for light polarized within the a-b planes and along the c axis. Below the charge-ordering temperature, Tco≃319K , a charge gap opens and the electronic background, upon which four strong infrared-active phonons are superimposed, drops towards zero. As the temperature decreases, many new spectral features are observed in response to the ordering of interstitial oxygen as well as the formation of a superlattice due to the charge order in the NiO2 planes. In particular, the prominent mode at 354cm-1 splits into three components; while the frequencies do not shift below the magnetic-ordering transition at Tm=110K , there is a transfer of oscillator strength in response to the change in registry of the charge stripes with respect to the underlying lattice. Ab initio calculations have been performed using density-functional theory, and the phonon dispersion curves were obtained using the direct method. Likely assignments of the new modes activated by stripe order are discussed. In some crystals, two antiresonances are observed in the conductivity for T≃Tco , which change to a resonant character for T≲Tm ; these modes are shown to be due to longitudinal optic c -axis modes which appear as a result of surface misorientation.

  12. SPECTRUM OF CERVICAL LESIONS IN CIMS, BILASPUR: A 5 YEAR RETROSPECTIVE STUDY OF 215 CASES IN A TERTIARY HOSPITAL OF CENTRAL INDIA

    Directory of Open Access Journals (Sweden)

    Sadhna

    2015-10-01

    Full Text Available BACKGROUND AND OBJEC TIVE: Cancer of the cervix is a leading cause of morbidity and mortality among women W orld W ide. Therefore to curb the disease there is need of awareness of this disease. This study is aimed to categorize the premalignant and malignant lesions at the earliest, to reduce the mortality and morbidity. It also aimed to know the incidence of malignancies at our set up and to calculate distribution of patient in relation to parity and symptoms. DESIGN AND SETTING: Study included 215 patients with complain of white dis charge per vagina, per vaginal bleeding and backache attending the gynecology OPD over a period of 05 years. PATIENT AND METHODS: Patients were subjected to cervical biopsy and biopsies were sent to pathology department. Detailed clinical history, age, age at marriage, parity and socio - economic status was obtained. RESULT: Result were classified histopathological l y as inflammatory lesions 70 cases, polypoidal lesion were 30, LSIL accounted for 32 cases and HSIL were 20 cases and 30 were malignant lesions. U nder malignant category moderately differentiated squamous cell carcinoma was the commonest. Maximum numbers of patients were subjected to cervical biopsies in 3 rd decade of life. Malignancies were common in 3 rd & 4 th decade of life. Most of the cases were of parity 4. CONCLUSION : Tissue biopsy is a valuable diagnostic procedure on which surgeons and radiologists still rely.

  13. 215例性病可疑标本应用PCR技术同步检测淋球菌、沙眼衣原体、解脲支原体结果分析%PCR Detection for Gonococcus, Chlamydia Trachomatis and Mycoplasma Urealytium From 215 Samples of Suspected Venereal Diseases

    Institute of Scientific and Technical Information of China (English)

    朱树敏

    2002-01-01

    @@ 近年来,性传播疾病出现明显上升趋势,尤其是淋球菌(NGH)、沙眼衣原体(CT)、解脲支原体(MU)等病原体感染引起的性病,上升趋势最为显著,成为临床最常见的三种性病.通过对215例可疑标本应用PCR技术同步检测NGH、CT、MU三种病原体,目的是了解三种病原体在性病中的分布情况.

  14. 长脉冲1064nm Nd:YAG激光治疗婴幼儿皮肤血管瘤215例疗效分析%A clinical effect analysis of long-pulsed 1064 nm Nd:YAG laser in the treatment of 215 infancy hemangiomas

    Institute of Scientific and Technical Information of China (English)

    曹丽华; 张美华; 吕东; 秦萍萍; 周洋

    2012-01-01

    Objectives: To observe the clinical effects of long-pulsed 1 064 nm Nd:YAG laser in the treatment of heman-giomas of skin in infant and investigate its related factors. Methods: Total 215 cases were treated with long-pulsed 1 064 nm Nd:YAG laser according to different disease types, including 19 cases of port wine stains, 179 cases of strawberry heman-giomas and 17 cases of mixed hemangiomas. The association between clinical effect and types, size, location and times of treatment of hemangiomas was also analyzed. Results: Among 215 cases, 133 were cured, 67 gained marked effect, 8 gaining effective therapy and 7 ineffective. The cure rate and total efficacy rate were 61.9% and 93.1%, respectively. The effect was related with the type, size and treatment times of hemangiomas. However, the location of hemangiomas was not associated with the therapy effect. The side-effect rate was 48.8% with temporary hyper-pigmentation, 8.3% with temporary hypo-pigmentation, 4.6% with superficial scar and 3.7% with hair reduction or disappearance. Conclusion: The long-pulsed 1 064nm Nd:YAG laser is an effective, safe and low side-effect treatment for infancy hemangiomas.%目的:观察长脉冲1064nm Nd:YAG激光治疗婴幼儿皮肤血管瘤临床疗效,并探讨影响疗效的相关因素.方法:应用长脉冲1 064 nm Nd:YAG激光治疗婴幼儿皮肤血管瘤215例,其中鲜红斑痣19例,草莓状血管瘤179例,混合型血管瘤17例.分析其疗效与病变类型、瘤体大小、病变部位及治疗次数的关系.结果:215例患儿中治愈133例,显效67例,有效8例,无效7例,痊愈率和有效率分别为61.9%和93.1%.疗效与血管瘤的病变类型、瘤体的大小以及治疗次数有关,但与其病变部位无明显相关性.治疗后暂时性色素沉着、暂时性色素减退、浅表性瘢痕、头部毛发减少或消失的发生率分别为48.8%、8.3%、4.6%和3.7%.结论:长脉冲1064nm Nd:YAG激光治疗婴幼儿皮肤血管瘤疗效好,

  15. Competition between ferromagnetism and frustrated antiferromagnetism in quasi 2D Ce2.15(Pd1-x Ag x )1.95In0.9 alloys

    Science.gov (United States)

    Sereni, J. G.; Giovannini, M.; Gómez Berisso, M.; Gastaldo, F.

    2016-11-01

    Low temperature thermal and magnetic measurements performed on ferro-magneticl (FM) alloys of composition Ce2.15(Pd1-x Ag x )1.95In0.9 are presented. Pd substitution by Ag depresses {{T}\\text{C}}(x) from 4.1 K down to 1.1 K for x  =  0.5, which is related to the increase of band electrons, with a critical concentration extrapolated to {{x}\\text{cr}}≈ 0.6 . The {{T}\\text{C}}(x) decrease is accompanied by a weakening of the magnetization of the FM phase. At high temperature (T  >  30 K) the inverse magnetic susceptibility reveals the presence of robust magnetic moments (2.56≥slant ~{μ\\text{eff}}≥slant 2.4 {μ\\text{B}} ), whereas the low value of the Curie-Weiss temperature {θP}≈ -10 K excludes any relevant effect from Kondo screening. The specific heat jump at {{T}\\text{C}}(x) decreases accordingly, while an anomaly emerges at a fixed temperature {{T}\\ast}≈ 1 K. This unexpected anomaly does not show any associated sign of magnetism checked by AC-susceptibility measurements. Since the total magnetic entropy (evaluated around T={{T}\\text{C}}(x=0) ) practically does not change with Ag concentration, the transference of degrees of freedom from the FM component to the non-magnetic T * anomaly is deduced. The origin of this anomaly is attributed to an arising magnetic frustration of the ground state and the consequent entropy bottleneck produced by the divergent increasing of density of excitations at low temperature.

  16. Stripe Order and Vibrational Properties of La{2}NiO{4+delta}for delta=2/15: Measurements and Ab Initio Calculations

    Energy Technology Data Exchange (ETDEWEB)

    Homes,C.; Tranquada, J.; Buttrey, D.

    2007-01-01

    The optical properties of the static charge- and stripe-ordered material La{sub 2}NiO{sub 4+{delta}} for {delta} = 2/15 have been measured over a wide frequency and temperature range for light polarized within the a-b planes and along the c axis. Below the charge-ordering temperature, T{sub co} 319 K, a charge gap opens and the electronic background, upon which four strong infrared-active phonons are superimposed, drops towards zero. As the temperature decreases, many new spectral features are observed in response to the ordering of interstitial oxygen as well as the formation of a superlattice due to the charge order in the NiO{sub 2} planes. In particular, the prominent mode at 354 cm{sup -1} splits into three components; while the frequencies do not shift below the magnetic-ordering transition at T{sub m} = 110 K, there is a transfer of oscillator strength in response to the change in registry of the charge stripes with respect to the underlying lattice. Ab initio calculations have been performed using density-functional theory, and the phonon dispersion curves were obtained using the direct method. Likely assignments of the new modes activated by stripe order are discussed. In some crystals, two antiresonances are observed in the conductivity for T {approx_equal} T{sub co}, which change to a resonant character for T {approx}< T{sub m}; these modes are shown to be due to longitudinal optic c-axis modes which appear as a result of surface misorientation.

  17. Postoperative treatment of glioblastoma multiforme with radiation therapy plus concomitant and adjuvant temozolomide : A mono-institutional experience of 215 patients

    Directory of Open Access Journals (Sweden)

    Pramod Kumar Julka

    2013-01-01

    Full Text Available Objective: To study the clinical results and prognostic factors of patients with glioblastoma multiforme (GBM treated by postoperative radiation therapy (PORT and concomitant temozolomide followed by adjuvant temozolomide. Methods: From 2005 to 2008, 215 patients (median age 48 years with GBM were treated with PORT plus temozolomide chemotherapy. Radiation therapy (RT was employed with a dose of 60 Gy in 30 fractions over 6 weeks by conventional fractionation with concomitant temozolomide (75 mg/m 2 /day. Adjuvant therapy consisted of 6 cycles of temozolomide (150 mg/m 2 for 5 days, 28 days cycle. The primary end point of the study was overall survival (OS, and the secondary end points were progression free survival (PFS and toxicity. OS was determined with respect to different variables to study the prognostic significance. Results: Median follow up was 11 months (range 2-50 months. Median OS and PFS were 13 months and 11 months respectively. The 1-year and 2-year OS was 44% and 18% respectively. There was no statistical significant impact of age, sex, KP score, anatomical location and extent of surgery. Presentation without seizures (on univariate analysis and 6 cycles of adjuvant temozolomide therapy (on univariate as well as multivariate analysis were found significant prognostic factors. Sixteen patients developed grade III-IV neutropenia/thrombocytopenia during the course of RT. Conclusion: Our results authenticate the role of concomitant and adjuvant temozolomide chemotherapy in combination with PORT for the management of GBM patients. We strongly recommend complete 6 cycle of adjuvant temozolomide since it significantly improved the survival in our study.

  18. Corrections of arterial input function for dynamic H215O PET to assess perfusion of pelvic tumours: arterial blood sampling versus image extraction

    Science.gov (United States)

    Lüdemann, L.; Sreenivasa, G.; Michel, R.; Rosner, C.; Plotkin, M.; Felix, R.; Wust, P.; Amthauer, H.

    2006-06-01

    Assessment of perfusion with 15O-labelled water (H215O) requires measurement of the arterial input function (AIF). The arterial time activity curve (TAC) measured using the peripheral sampling scheme requires corrections for delay and dispersion. In this study, parametrizations with and without arterial spillover correction for fitting of the tissue curve are evaluated. Additionally, a completely noninvasive method for generation of the AIF from a dynamic positron emission tomography (PET) acquisition is applied to assess perfusion of pelvic tumours. This method uses a volume of interest (VOI) to extract the TAC from the femoral artery. The VOI TAC is corrected for spillover using a separate tissue TAC and for recovery by determining the recovery coefficient on a coregistered CT data set. The techniques were applied in five patients with pelvic tumours who underwent a total of 11 examinations. Delay and dispersion correction of the blood TAC without arterial spillover correction yielded in seven examinations solutions inconsistent with physiology. Correction of arterial spillover increased the fitting accuracy and yielded consistent results in all patients. Generation of an AIF from PET image data was investigated as an alternative to arterial blood sampling and was shown to have an intrinsic potential to determine the AIF noninvasively and reproducibly. The AIF extracted from a VOI in a dynamic PET scan was similar in shape to the blood AIF but yielded significantly higher tissue perfusion values (mean of 104.0 ± 52.0%) and lower partition coefficients (-31.6 ± 24.2%). The perfusion values and partition coefficients determined with the VOI technique have to be corrected in order to compare the results with those of studies using a blood AIF.

  19. NuSTAR study of hard X-ray morphology and spectroscopy of PWN G21.5–0.9

    Energy Technology Data Exchange (ETDEWEB)

    Nynka, Melania; Hailey, Charles J.; Gotthelf, Eric V.; Mori, Kaya; Perez, Kerstin [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Reynolds, Stephen P. [Physics Department, NC State University, Raleigh, NC 27695 (United States); An, Hongjun [Department of Physics, McGill University, Rutherford Physics Building, 3600 University Street, Montreal, Quebec H3A 2T8 (Canada); Baganoff, Frederick K. [Center for Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139-4307 (United States); Boggs, Steven E.; Krivonos, Roman; Zoglauer, Andreas [Space Sciences Laboratory, University of California, Berkeley, CA 94720 (United States); Christensen, Finn E. [DTU Space, National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Craig, William W. [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Grefenstette, Brian W.; Harrison, Fiona A.; Madsen, Kristin K. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Stern, Daniel [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Wik, Daniel R.; Zhang, William W. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2014-07-01

    We present NuSTAR high-energy X-ray observations of the pulsar wind nebula (PWN)/supernova remnant G21.5–0.9. We detect integrated emission from the nebula up to ∼40 keV, and resolve individual spatial features over a broad X-ray band for the first time. The morphology seen by NuSTAR agrees well with that seen by XMM-Newton and Chandra below 10 keV. At high energies, NuSTAR clearly detects non-thermal emission up to ∼20 keV that extends along the eastern and northern rim of the supernova shell. The broadband images clearly demonstrate that X-ray emission from the North Spur and Eastern Limb results predominantly from non-thermal processes. We detect a break in the spatially integrated X-ray spectrum at ∼9 keV that cannot be reproduced by current spectral energy distribution models, implying either a more complex electron injection spectrum or an additional process such as diffusion compared to what has been considered in previous work. We use spatially resolved maps to derive an energy-dependent cooling length scale, L(E)∝E{sup m} with m = –0.21 ± 0.01. We find this to be inconsistent with the model for the morphological evolution with energy described by Kennel and Coroniti. This value, along with the observed steepening in power-law index between radio and X-ray, can be quantitatively explained as an energy-loss spectral break in the simple scaling model of Reynolds, assuming particle advection dominates over diffusion. This interpretation requires a substantial departure from spherical magnetohydrodynamic, magnetic-flux-conserving outflow, most plausibly in the form of turbulent magnetic-field amplification.

  20. Detection and functional characterization of a 215 amino acid N-terminal extension in the Xanthomonas type III effector XopD.

    Science.gov (United States)

    Canonne, Joanne; Marino, Daniel; Noël, Laurent D; Arechaga, Ignacio; Pichereaux, Carole; Rossignol, Michel; Roby, Dominique; Rivas, Susana

    2010-12-22

    During evolution, pathogens have developed a variety of strategies to suppress plant-triggered immunity and promote successful infection. In Gram-negative phytopathogenic bacteria, the so-called type III protein secretion system works as a molecular syringe to inject type III effectors (T3Es) into plant cells. The XopD T3E from the strain 85-10 of Xanthomonas campestris pathovar vesicatoria (Xcv) delays the onset of symptom development and alters basal defence responses to promote pathogen growth in infected tomato leaves. XopD was previously described as a modular protein that contains (i) an N-terminal DNA-binding domain (DBD), (ii) two tandemly repeated EAR (ERF-associated amphiphillic repression) motifs involved in transcriptional repression, and (iii) a C-terminal cysteine protease domain, involved in release of SUMO (small ubiquitin-like modifier) from SUMO-modified proteins. Here, we show that the XopD protein that is produced and secreted by Xcv presents an additional N-terminal extension of 215 amino acids. Closer analysis of this newly identified N-terminal domain shows a low complexity region rich in lysine, alanine and glutamic acid residues (KAE-rich) with high propensity to form coiled-coil structures that confers to XopD the ability to form dimers when expressed in E. coli. The full length XopD protein identified in this study (XopD(1-760)) displays stronger repression of the XopD plant target promoter PR1, as compared to the XopD version annotated in the public databases (XopD(216-760)). Furthermore, the N-terminal extension of XopD, which is absent in XopD(216-760), is essential for XopD type III-dependent secretion and, therefore, for complementation of an Xcv mutant strain deleted from XopD in its ability to delay symptom development in tomato susceptible cultivars. The identification of the complete sequence of XopD opens new perspectives for future studies on the XopD protein and its virulence-associated functions in planta.

  1. 锂离子电池研究与发展的最新态势——第215届电化学会议评述%Updated research and development status of Li-ion batteries——Report on the 215th Electrochemical Society Meeting

    Institute of Scientific and Technical Information of China (English)

    郑洪河

    2009-01-01

    介绍了2009年5月24-29日在美国旧金山举行的第215届电化学会议的情况,对本次会议中有关锂离子电池的学术发展与最新动态进行了分析.新材料的开发和电池系统的设计与模拟是本届会议的主要亮点,会议报道了一些达到混联式动力汽车(PHEV)用锂离子电池标准的锂离子电池体系,如LiNi1/3Co1/3Mn1/3O2/C、LiFePO4/C和LiMn2O4/C等.总体来看,围绕提高电池比能量、循环寿命、储存寿命和安全性的研究仍将是今后的研究热点.

  2. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  3. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  4. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  5. Best Practices, Creative Ideas, Linking all data, Exploring the Future:The Summary of the 12th Advanced Digital Library Seminar & Lib 2.15 Conference%知行合一 创新创意 关联无限 开拓未来——第12届数字图书馆前沿问题高级研讨班暨Lib2.15会议综述

    Institute of Scientific and Technical Information of China (English)

    杨薇; 陈晓亮; 黄国凡

    2015-01-01

    2015年7月6日至8日,第12届数字图书馆前沿问题高级研讨班暨Lib2.15会议在厦门大学图书馆举行.三天的议程涵盖数据服务、关联数据、数字人文、图书馆合作及行业未来等五项分主题内容.通过对会议报告和分享案例的梳理,提出图书馆的未来发展取决于树立终身学习的思想,寻求更大范围的合作,项目实施体现人的价值以及无边界创新创意.

  6. Oceanographic profile data collected from sound velocimeter - moving vessel profiler casts aboard BLAKE as part of project OPR-J377-KR2-15 in the Gulf of Mexico from 2015-06-03 to 2015-10-30 (NCEI Accession 0139358)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0139358 includes physical and profile data collected aboard the BLAKE during project OPR-J377-KR2-15 in the Gulf of Mexico from 2015-06-03 to...

  7. Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells.

    Science.gov (United States)

    Tripathi, Shubhandra; Srivastava, Gaurava; Sharma, Ashok

    2016-08-05

    Drug resistance poses a threatening challenge for mankind, as the development of resistance to already well-established drugs causes serious therapeutic problems. Resistance to paclitaxel (Ptxl), a complex diterpenoid working as microtubule stabilizer, is one such issue in cancer treatment. Microtubule stabilizer drugs, stabilises microtubules upon binding to β-tubulin subunit of tubulin heterodimer thus causing mitotic arrest leading to death of cancer cell. Leucine point mutations viz. L215H, L217R, and L225M were reported for Ptxl resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations was explored using molecular docking, molecular dynamics (MD) simulation, binding energy estimation (MMPBSA), free energy decomposition, principle component analysis (PCA) and free energy landscape (FEL) methods. A total of five systems including unbound βI-tubulin (Apo), docked wild+Ptxl, L215H+Ptxl, L217R+Ptxl and L225M+Ptxl were prepared, and 50 ns MD simulation was performed for each system. Binding energy estimation indicated that leucine mutation reduces the binding affinity of Ptxl in mutant types (MTs) as compared to wild type (WT). Further, in contrast to WT Ptxl interactions with the M-loop (PHE270-VAL286), S6-S7 loop and H9-H10 were significantly altered in MTs. Results showed that in MTs, Ptxl had weak interaction with M-loop residues, while having strong affinity with S6-S7 loop and H6-H7 loop. Moreover, PCA and FEL analysis revealed that M-loop flexible region (THR274-LEU284) was strongly bound with Ptxl in WT preventing its flexible movement and the causing factor for microtubule stabilization. In MTs due to poor interaction with Ptxl, M-loop flexible region retains its flexibility, therefore unable to stabilize microtubule. This study will give an insight into the importance of M-loop flexible region interaction with Ptxl for microtubule stabilization. In addition, it clearly provides the molecular basis of

  8. Effect of Sol-Gel Ageing Time on Three Dimensionally Ordered Macroporous Structure of 80SiO2-15CaO-5P2O5 Bioactive Glasses

    Directory of Open Access Journals (Sweden)

    Thanida CHAROENSUK

    2014-04-01

    Full Text Available Three dimensionally ordered macroporous bioactive glasses (3DOM-BGs, namely 80SiO2-15CaO-5P2O5, were synthesized by sol-gel method. PMMA colloidal crystals and non-ionic block copolymers P123 were used as cotemplates. The amorphous 3DOM-BGs had skeletal walls enclosing macropores. Such structure resulted from octahedral and tetrahedral holes of the face-centered cubic (fcc closest packed PMMA templates and windows interconnecting through macropores network. The thicknesses of the walls were around 50 nm – 80 nm and the windows were 90 nm – 110 nm in diameter. These wall thickness is increased by with an increase in ageing time up to 24 h and  then gradually reduced with further increase in aging time. Vibration bands of Si–O–Si and P–O were evident in infrared spectra which are in agreement with EDS spectra indicating Si, P and Ca compositions. After in vitro bioactivity testing by soaking 3DOM-BGs in simulated body fluid at 37 °C, the crystallization of amorphous calcium phosphate layers compatible to the bone component of hydroxyl carbonate apatite were rapidly formed within 3 h. These results indicated that these 3DOM-BGs resembled ideal bone implant materials.DOI: http://dx.doi.org/10.5755/j01.ms.20.1.4755

  9. Structural characterization, thermal, ac conductivity and dielectric properties of (C7H12N2)2[SnCl6]Cl2.1.5H2O

    Science.gov (United States)

    Hajji, Rachid; Oueslati, Abderrazek; Hajlaoui, Fadhel; Bulou, Alain; Hlel, Faouzi

    2016-05-01

    (C7H12N2)2[SnCl6]Cl2.1.5H2O is crystallized at room temperature in the monoclinic system (space group P21/n). The isolated molecules form organic and inorganic layers parallel to the (a, b) plane and alternate along the c-axis. The inorganic layer is built up by isolated SnCl6 octahedrons. Besides, the organic layer is formed by 2,4-diammonium toluene cations, between which the spaces are filled with free Cl- ions and water molecules. The crystal packing is governed by means of the ionic N-H...Cl and Ow-H...Cl hydrogen bonds, forming a three-dimensional network. The thermal study of this compound is reported, revealing two phase transitions around 360(±3) and 412(±3) K. The electrical and dielectric measurements were reported, confirming the transition temperatures detected in the differential scanning calorimetry (DSC). The frequency dependence of ac conductivity at different temperatures indicates that the correlated barrier hopping (CBH) model is the probable mechanism for the ac conduction behavior.

  10. Diffuse phase transition and impedance spectroscopy analysis of Ba2.15- x Na0.7+ x Nb5- x W x O15 ( x = 0.25) ferroelectric ceramic

    Science.gov (United States)

    Neqali, A.; Belboukhari, A.; Bensaid, H.; El Bouari, A.; Bih, L.; Alimoussa, A.; Habouti, S.; Mezzane, D.

    2016-06-01

    A new rare earth ferroelectric tetragonal tungsten bronze compound with general formula Ba2.15- xNa0.7+ xNb5- xWxO15 ( x = 0.25) was elaborated as ceramic and investigated using X-ray diffraction and dielectric measurements. The results show a tetragonal phase with the space group P4bm. Special emphasis was done to characterize diffuse phase transition (DPT) that occurs close to 472 °C. Using dielectric measurements in a frequency range of (10 Hz-1 MHz) and in a temperature range (25-550 °C), we have shown that the real part of the permittivity close to DPT is well described by Santos-Eiras phenomenological model. Space charge polarization, relaxation phenomena and free charges conductivity have been analyzed using dielectric, impedance spectroscopy and Nyquist plots showed non-Debye (polydispersive) type relaxation. In paraelectric phase, the Arrhenius activation energies were determined. Frequency dependence of ac conductivity at different temperatures follows the Jonscher's universal law (Jonscher et al. in J Mater Sci 20:4431, 1985).

  11. Paleomagnetism of Basaltic Lava Flows in Coreholes ICPP 213, ICPP-214, ICPP-215, and USGS 128 Near the Vadose Zone Research Park, Idaho Nuclear Technology and Engineering Center, Idaho National Engineering and Environmental Laboratory, Idaho

    Science.gov (United States)

    Champion, Duane E.; Herman, Theodore C.

    2003-01-01

    A paleomagnetic study was conducted on basalt from 41 lava flows represented in about 2,300 ft of core from coreholes ICPP-213, ICPP-214, ICPP-215, and USGS 128. These wells are in the area of the Idaho Nuclear Technology and Engineering Center (INTEC) Vadose Zone Research Park within the Idaho National Engineering and Environmental Laboratory (INEEL). Paleomagnetic measurements were made on 508 samples from the four coreholes, which are compared to each other, and to surface outcrop paleomagnetic data. In general, subhorizontal lines of correlation exist between sediment layers and between basalt layers in the area of the new percolation ponds. Some of the basalt flows and flow sequences are strongly correlative at different depth intervals and represent important stratigraphic unifying elements. Some units pinch out, or thicken or thin even over short separation distances of about 1,500 ft. A more distant correlation of more than 1 mile to corehole USGS 128 is possible for several of the basalt flows, but at greater depth. This is probably due to the broad subsidence of the eastern Snake River Plain centered along its topographic axis located to the south of INEEL. This study shows this most clearly in the oldest portions of the cored sections that have differentially subsided the greatest amount.

  12. Radioimmunotherapy for first-line and relapse treatment of aggressive B-cell non-Hodgkin lymphoma: an analysis of 215 patients registered in the international RIT-Network

    Energy Technology Data Exchange (ETDEWEB)

    Hohloch, Karin; Lankeit, H.K.; Truemper, L. [Georg August University, Hematology and Oncology, Goettingen (Germany); Zinzani, P.L. [University of Bologna, Institute of Hematology and Medical Oncology ' ' L. e A. Seragnoli' ' , Bologna (Italy); Scholz, C.W. [Charite, University Berlin, Hematology, Oncology and Tumor Immunology, Berlin (Germany); Lorsbach, M.; Windemuth-Kieselbach, C. [Alcedis GmbH, Giessen (Germany)

    2014-08-15

    Very few reliable clinical data about the use of radioimmunotherapy in aggressive B-cell lymphoma exist. Patients with aggressive B-cell lymphoma registered in the international RIT-Network were analysed with regard to prior treatment, response and side effects. The RIT-Network is a web-based registry that collects observational data from radioimmunotherapy-treated patients with malignant lymphoma across 13 countries. This analysis included 215 with aggressive B-cell lymphoma out of 232 patients registered in the RIT-Network. Histological subtypes were as follows: 190 diffuse large B-cell, 15 primary mediastinal, 9 anaplastic large cell, and 1 intravascular lymphoma. The median age of the patients was 62 years (range 17 - 88), with 27 % above the age of 70 years. Radioimmunotherapy was mainly used as consolidation after first-line or second-line chemotherapy (56.1 %), as part of third-line to eighth-line therapy for relapse (16.4 %), and in refractory disease (12.2 %). Grade IV neutropenia and thrombopenia and grade III anaemia were observed. The median time to recovery of blood count was 81 days (range 0 - 600 days). The overall response rate was 63.3 %. The complete response rate was 76.4 % in patients treated as part of first-line therapy, and 44.3 % in patients with relapse. Mean overall survival in first-line therapy patients was 32.7 months and 14.0 months in patients with relapse or refractory disease, respectively. Most patients with aggressive B-cell lymphoma in the RIT-Network received radioimmunotherapy as consolidation after first-line therapy with excellent complete remission and overall survival rates compared to published data. In relapsed aggressive B-cell lymphoma, radioimmunotherapy is a safe and feasible treatment leading to satisfactory response rates with acceptable toxicity. (orig.)

  13. 24 CFR 91.215 - Strategic plan.

    Science.gov (United States)

    2010-04-01

    ... governmental health, mental health, and service agencies. With respect to the preparation of its homeless... (mental, physical, developmental), persons with alcohol or other drug addiction, persons with HIV/AIDS...

  14. 49 CFR 372.215 - Ravenswood, WV.

    Science.gov (United States)

    2010-10-01

    ...)(1) includes and is comprised of all points as follows: (a) The municipality of Ravenswood, W. Va... section, and which are north of U.S. Highway 33; (d) All of any municipality any part of which is within... municipality wholly surrounded, or so surrounded except for a water boundary, by the municipality of...

  15. 2 CFR 215.34 - Equipment.

    Science.gov (United States)

    2010-01-01

    ... to non-Federal outside organizations for a fee that is less than private companies charge for... shall be in effect to insure adequate safeguards to prevent loss, damage, or theft of the equipment. Any... which provide for competition to the extent practicable and result in the highest possible return....

  16. 2 CFR 215.44 - Procurement procedures.

    Science.gov (United States)

    2010-01-01

    ... metric system of measurement. (vi) Preference, to the extent practicable and economically feasible, for... performance, financial and technical resources or accessibility to other necessary resources. In...

  17. 22 CFR 215.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ..., financial transactions, medical history, and criminal or employment history and that contains his name, or...; (h) Statistical record means a record in a system of records maintained for statistical research...

  18. 22 CFR 215.14 - Specific exemptions.

    Science.gov (United States)

    2010-04-01

    ... to 18 U.S.C. 3056; (4) Required by statute to be maintained and used solely as statistical records... exemptions, are set forth below: (1) Criminal Law Enforcement Records. If the 5 U.S.C. 552a(j)(2)...

  19. 12 CFR 215.4 - General prohibitions.

    Science.gov (United States)

    2010-01-01

    ... corporation wholly owned directly or indirectly by the United States; (C) Extensions of credit secured by a... bank or insider of its affiliates unless the extension of credit: (i) Is made on substantially the same... the member bank and, in the case of extensions of credit to an insider of its affiliates, is...

  20. Case 215: voriconazole-induced periostitis.

    Science.gov (United States)

    Tailor, Tina D; Richardson, Michael L

    2015-03-01

    History A 74-year-old woman presented with multifocal bone pain, including pain in multiple ribs, bilateral shoulders, and bilateral hips. The pain began several months before presentation and was quite severe, ultimately necessitating control with narcotics. At examination, strength in both lower extremities was slightly reduced, sensation and reflexes were intact, and range of motion was full, though painful. There were no notable constitutional symptoms of fever or weight loss. Laboratory work-up was remarkable for elevated alkaline phosphatase level (277 U/L [4.6 mkat/L]). The patient had undergone left lung transplantation 8 years prior for pulmonary fibrosis. A thorough pulmonary work-up for the cause of fibrosis, which included gathering an exposure, occupational, allergy, and previous infectious history, and a rheumatoid work-up were negative. The patient's posttransplantation course was complicated by bronchiolitis obliterans from chronic rejection and by recent pulmonary embolism, for which she was undergoing anticoagulation therapy at the time of presentation. Additionally, the patient experienced repeated pulmonary infections with Aspergillus, leading to multiple hospitalizations and long-term antifungal prophylaxis with voriconazole. A bone scan from an outside hospital was reviewed, and further imaging was performed.

  1. 9 CFR 93.215 - Special provisions.

    Science.gov (United States)

    2010-01-01

    ... be recorded on the United States health certificate, or a paper containing the information shall be... veterinary inspector at the United States port of entry that the poultry are the identical poultry covered by..., That all poultry offered for re-entry upon examination by the veterinary inspector at the U.S. port...

  2. 2 CFR 215.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... acquisition cost in accordance with the recipient's regular accounting practices. (d) Advance means a payment...'s or subrecipient's contract. (i) Cost sharing or matching means that portion of project or program... awarding agency determines to be unallowable, in accordance with the applicable Federal cost principles...

  3. 49 CFR 215.7 - Prohibited acts.

    Science.gov (United States)

    2010-10-01

    ... persons, or has caused death or injury, a penalty not to exceed $100,000 per violation may be assessed... requirement is subject to a civil penalty of at least $650 and not more than $25,000 per violation, except that: Penalties may be assessed against individuals only for willful violations, and, where a...

  4. Reference: 215 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available trimental effects by various DNA damaging agents. A tolerance pathway that has been predicted to be present in higher...rev3, was inhibited by long-term UV-B. These results suggest that a TLS mechanism exists in a higher plant a

  5. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  6. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  7. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  8. Identification of a new tert-leucinate class synthetic cannabinoid in powder and "spice-like" herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA).

    Science.gov (United States)

    Risseeuw, Martijn D P; Blanckaert, Peter; Coopman, Vera; Van Quekelberghe, Stijn; Van Calenbergh, Serge; Cordonnier, Jan

    2017-02-04

    A brown powder and different product packages of "spice-like" herbal incenses were analyzed using a systematic identification approach based on liquid chromatography with diode array detector (HPLC-PDA) and gas chromatography mass spectrometry (GC-MS) with computer based library search against spectral libraries. However, the most predominant compound in the methanolic sample solutions could not be identified. In order to elucidate the chemical structure, a more extensive analysis of the material was initiated using liquid chromatography mass spectrometry (LC-MS), electrospray high resolution mass spectrometry (ESI-HRMS) and (1)H, (13)C and (19)F nuclear magnetic resonance spectroscopy (NMR), which allowed the identification and characterization of the major compound as methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA). The goal of this study is to provide analytical information for the identification of this new tert-leucinate class synthetic cannabinoid by various analytical methods.

  9. Dicty_cDB: CFG215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ne 1GAL_17H10 5', mRNA sequence. 42 2e-05 3 BG711333 | ( S74728 ) antiquitin=26g turgor protein homolog [hum...8 3e-58 AY883858_1( AY883858 |pid:none) Sterkiella histriomuscorum turgor ... 224 3e-57 protein update 2009.

  10. Nuclear Operations Air Force Doctrine Document 2-1.5.

    Science.gov (United States)

    2007-11-02

    iN •. .... .?:.......... .......@ .! ii~ iiiiii@!! Effec4:igve cofmn n co trolh~~g (2) isoy critica forthed proper...such things as day-to-day mainte- nance and support operations, generatingbombers and ICBMs for nuclear alert in a crisis , deployment into a theater of

  11. DNA tests for strawberry: perpetual flowering - Bx215

    Science.gov (United States)

    Perpetual flowering strawberries have great economic value to the fresh market industry. Floral initiation in strawberry is largely determined by photoperiod, temperature, and genetics. Commercially grown strawberries are generally classified as remontant (repeated or perpetual flowering, day neutr...

  12. Hardness Analysis. Training Module 5.215.2.77.

    Science.gov (United States)

    Bonte, John L.; Davidson, Arnold C.

    This document is an instructional module package prepared in objective form for use by an instructor familiar with hardness analysis using the EDTA method and the calculation of hardness given metal ion concentrations and a factor table. Included are objectives, an instructor guide, student handouts, and transparency masters. A video tape is also…

  13. 40 CFR 21.5 - Issuance of statements.

    Science.gov (United States)

    2010-07-01

    ... applicant to that effect, within 45 working days following receipt of the application, or within 45 working... Administrator shall promptly, but in no event later than 30 working days following receipt of the application... significantly differing in scope, concept, or capability. It is expected that the applicant at the time...

  14. Dicty_cDB: VSA215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available osome IV cosmid 9934. 46 0.15 2 AI775835 |AI775835.1 EST256935 tomato resistant, Cornell Lycopersicon escule...21334 tomato flower buds 3-8 mm, Cornell University Lycopersicon esculentum cDNA clone cTOB10G7 5', mRNA seq

  15. 46 CFR 10.215 - Medical and physical requirements.

    Science.gov (United States)

    2010-10-01

    ... infarctions, psychiatric disorders, and convulsive disorders. (2) Food handlers are not required to submit to... the sense of balance; (ii) Is able, without assistance, to climb up and down vertical ladders...

  16. Dicty_cDB: VSD215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available msktavcvikgekvngvvkftqenkdspvtvnyditglekgehgfh vhafgdttngcvsagphfnpfgknhgapsdedrhvgdlgnivadgesntkgtisdkiisl fgeht...itglekgehgfh vhafgdttngcvsagphfnpfgknhgapsdedrhvgdlgnivadgesntkgtisdkiisl fgehtivgrtmvvhadqddlgkggkpdslttgaa

  17. 40 CFR 98.215 - Procedures for estimating missing data.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Procedures for estimating missing data... for estimating missing data. (a) A complete record of all measured parameters used in the GHG... unavailable, a substitute data value for the missing parameter shall be used in the calculations as...

  18. 48 CFR 1352.215-70 - Proposal preparation.

    Science.gov (United States)

    2010-10-01

    ... related corporate experience documentation. Any pages in excess of __ will be disregarded, and will not be... duplication/reproduction, meetings and conferences, postage, communication and any other applicable...

  19. Dicty_cDB: AFA215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available sion library, 48 hours NaCl treatment prescreened for removal of highly abundant transcripts Mesembryanthemu...ant Lambda Uni-Zap XR expression library, 48 hours NaCl treatment prescreened for removal

  20. 48 CFR 1352.215-75 - Evaluation criteria.

    Science.gov (United States)

    2010-10-01

    ... requirements, quality and timeliness of delivery of goods and services, effective management of subcontractors... customer satisfaction. The Government reserves the right to assess the past performance of...

  1. 48 CFR 1552.215-75 - Past performance information.

    Science.gov (United States)

    2010-10-01

    ... description of contract or subcontract and relevance to this requirement. (f) Total contract value. (g) Period... businesses, which are of similar scope, magnitude, relevance, and complexity to the requirement which is... the award or certification is over three years old, present evidence that the qualifications...

  2. 29 CFR 553.215 - Ambulance and rescue service employees.

    Science.gov (United States)

    2010-07-01

    ... employees have received training in the rescue of fire, crime, and accident victims or firefighters or law... REGULATIONS APPLICATION OF THE FAIR LABOR STANDARDS ACT TO EMPLOYEES OF STATE AND LOCAL GOVERNMENTS Fire... rescue service employees. (a) Ambulance and rescue service employees of a public agency other than a...

  3. 40 CFR 180.215 - Naled; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... insecticide naled (1,2-dibromo-2,2-dichloro-ethyl dimethyl phosphate) and its conversion product 2,2-dichlorovinyl dimethyl phosphate, expressed as naled, resulting from the application of the pesticide to...

  4. 48 CFR 252.215-7002 - Cost estimating system requirements.

    Science.gov (United States)

    2010-10-01

    ...(2), use the following clause: Cost Estimating System Requirements (DEC 2006) (a) Definitions..., totaling $50 million or more for which cost or pricing data were required; or (2) In its fiscal year... more (but less than $50 million) for which cost or pricing data were required; and (ii) Was notified...

  5. 48 CFR 1352.215-76 - Cost or pricing data.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Cost or pricing data. 1352... pricing data. As prescribed in 48 CFR 1315.204-570(b)(4), insert the following provision: Cost or Pricing... Statement of Work. A brief definition of the education and experience requirements which qualify an...

  6. Dicty_cDB: CHK215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available kkiiits*sfndrcfiflivhlkilcqqiviavmmtmm kiiipimilklkmklkkilgyl*iivtp Homology vs C...id sequence ---MEIDMDLFNKISEKYKESKKKQQQIQQREKFKQNAPETQKSKQINQNNNNNNNNINN NNNNNNNNNGSTETKADKPSMIRRKSLLPVDPSTI... ---MEIDMDLFNKISEKYKESKKKQQQIQQREKFKQNAPETQKSKQINQNNNNNNNNINN NNNNNNNNNGSTETKADKPSMIRRKSLLPVDPSTIAALSFSSFT*r

  7. Dicty_cDB: CFJ215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available s vinifera cDNA clone VVB158G03 5, mRNA sequence. 64 5e-07 2 CA813481 |CA813481.1 CA48LN10IF-E8 Cabernet Sau...8.2 CA32EN0002_IIIbF_E01 Cabernet Sauvignon Leaf - CA32EN Vitis vinifera cDNA clone CA32EN0002_IIIbF_E01 5',...514038 |CF514038.1 CAbud0007_IVF_G07 Vitis vinifera cv. cabernet sauvignon (Clone 8) Bud - CABUD Vitis vinif

  8. Dicty_cDB: AFO215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available -collected Valencia Sweet Orange (Citrus sinensis (L.) Osbeck) Citrus sinensis cDNA clone MVF-70_B02 5', mRN...rom field-collected Valencia Sweet Orange (Citrus sinensis (L.) Osbeck) Citrus sinensis cDNA clone MVF-82_F0

  9. 28 CFR 2.215 - Place of revocation hearing.

    Science.gov (United States)

    2010-07-01

    ... OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS District of Columbia Supervised Releasees § 2... releasee has not been convicted of a crime committed while under supervision; and (2) The releasee...

  10. 48 CFR 2515.215-70 - NSF negotiation authorities.

    Science.gov (United States)

    2010-10-01

    ... entered into through negotiation rather than formal advertising. The Foundation's contracting officer may... international cooperation or national security.” Contracts or their modifications entered into under...

  11. Dicty_cDB: VSI215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Translated Amino Acid sequence ex*c*rtrrrrsrrrgrrttrrrrr*k**rin*rsrrrfprtpirn*shtkr*rfr*thf wllcftrr*lhclwf...GXTXNPXEIGGTSXEXQXKXXLVLQQNGNXERLSXFXPDXGPNKKN Frame B: ex*c*rtrrrrsrrrgrrttrrrrr*k**rin*rsrrrfprtpirn*shtkr*rfr*thf wllcftr

  12. Dicty_cDB: CFE215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available , *** SEQUENCING IN PROGRESS ***, 20 unordered pieces. 48 0.12 1 CF974266 |CF974266.1 PSU_nep1G03 Defense-related ESTs from Cacao Lea...ves Theobroma cacao cDNA, mRNA sequence. 44 1.9 1 AC1450

  13. 33 CFR 104.215 - Vessel Security Officer (VSO).

    Science.gov (United States)

    2010-07-01

    ... stowed aboard various vessel types; (E) Understanding of the operating principles of and proper use of... regulations and techniques. (v) Familiarity with key definitions, terminology, and operational practices... Transportation Security Act of 2002, Public Law 107-295. (ii) To be eligible to take a refresher Coast...

  14. Dicty_cDB: SSD215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ce ---nyklyhgt*rk*kslkkk*kiikk*kknxkknf*nspstfwcfc*ANAKVSLSPFAL HYSPQAQIISSSTNDAPXVSSGLIXHIPMQLSQMYKQSLTKKNX*kkkkkkkkryenifs...kslkkk*kiikk*kknxkknf*nspstfwcfc*ANAKVSLSPFAL HYSPQAQIISSSTNDAPXVSSGLIXHIPMQLSQMYKQSLTKKNX*kkkkkkkkryenifs k

  15. 29 CFR 1910.215 - Abrasive wheel machinery.

    Science.gov (United States)

    2010-07-01

    ... machines known as bench and floor stands should not exceed 90° or one-fourth of the periphery. This... peripheral member at the top shall never exceed one-fourth inch. (See Figures O-18, O-19, O-20, O-21, O-22, and O-23.) (10) Material requirements and minimum dimensions. (i) See Figures O-36 and O-37 and...

  16. Dicty_cDB: SSM215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available .002 1 AU176207 |AU176207.1 Penaeus japonicus cDNA forward end of clone:PJV601. 54 0.002 1 BX323881 |BX32388...AU175995.1 Penaeus japonicus cDNA forward end of clone:PJV77. 54 0.002 1 dna update 2003. 8.12 Homology vs P

  17. 48 CFR 215.404-71-4 - Facilities capital employed.

    Science.gov (United States)

    2010-10-01

    ... encouraging and rewarding capital investment in facilities that benefit DoD. It recognizes both the facilities... anticipated industrial base enhancing benefits resulting from the facilities capital investment, including— (A... investment recovery, such as termination protection clauses and capital investment indemnification. (2)...

  18. Dicty_cDB: SSB215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mRNA sequence. 48 1e-06 2 BQ476340 |BQ476340.1 curculio3e06.b Curculio glandium ...cDNA Curculio glandium cDNA clone curculio3e06 5', mRNA sequence. 46 0.38 1 BQ476622 |BQ476622.1 curculio3e0...6.g Curculio glandium cDNA Curculio glandium cDNA clone curculio3e06 3', mRNA sequence. 46 0.38 1 AC132016 |

  19. 48 CFR 2052.215-71 - Project officer authority.

    Science.gov (United States)

    2010-10-01

    ... and guidance to the contractor in the preparation of drawings, specifications, or technical portions..., drawings, specifications, and technical information to be delivered by the contractor to the Government... subject to the technical direction of the NRC project officer. The term technical direction is defined...

  20. 24 CFR 572.215 - Implementation grants-eligible activities.

    Science.gov (United States)

    2010-04-01

    ... related to implementing the affirmative fair housing marketing strategy required under § 572.110. (k...) Homebuyer outreach and selection. Reasonable and necessary costs of marketing the program to...

  1. Session 21.5 - Light at Night and Protected Areas

    Science.gov (United States)

    Zhao, Yongheng

    2016-10-01

    Light at night (LAN) is now an established environmental problem, not only for astronomers but for the population at large. It has serious ecological effects that are wide ranging, and its environmental effects may be more serious than ever imagined. The ecological and environmental consequences are examined and emphasis is stressed on resolving the problem before it is too late.

  2. 48 CFR 215.404-71-2 - Performance risk.

    Science.gov (United States)

    2010-10-01

    ... technologies. The technology incentive range does not apply to efforts restricted to studies, analyses, or... estimating system); (vi) The adequacy of the contractor's management approach to controlling cost and... internal control systems (e.g., quality assurance, property control, safety, security); or (B) The...

  3. Dicty_cDB: SSE215 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Arabidopsis thaliana At2g01970/F14H20.4 mRNA, complete cds. 40 2e-04 2 BU636652 |BU636652.1 002B07 Infect...ed Arabidopsis Leaf Arabidopsis thaliana cDNA, mRNA sequence. 40 2e-04 2 CB260308 |

  4. 48 CFR 215.404-75 - Fee requirements for FFRDCs.

    Science.gov (United States)

    2010-10-01

    ... FFRDC's— (1) Proportion of retained earnings (as established under generally accepted accounting methods... funding as assessed on operating cycle cash needs; and (4) Provision for funding unreimbursed costs...

  5. 49 CFR 240.215 - Retaining information supporting determinations.

    Science.gov (United States)

    2010-10-01

    ... administered. (e) The information concerning demonstrated performance skills that the railroad shall retain... permits reasonable access and retrieval of the information in usable format when requested to furnish data... 49 Transportation 4 2010-10-01 2010-10-01 false Retaining information supporting...

  6. 49 CFR 180.215 - Reporting and record retention requirements.

    Science.gov (United States)

    2010-10-01

    ... or reheat treatment records. (1) Records covering welding or brazing repairs, rebuilding or reheat... any; (iii) Cylinder outside diameter and length in inches; (iv) Rebuild process (welded, brazed, type...), Chromium (Cr), Molybdenum (Mo), Copper (Cu), Aluminum (Al), Zinc (Zn)), material manufacturer, name...

  7. 78 FR 65453 - Hazardous Materials: Corrections and Response to Administrative Appeals (HM-215K, HM-215L, HM...

    Science.gov (United States)

    2013-10-31

    ... Air (ICAO TI), and the United Nations Recommendations on the Transport of Dangerous Goods--Model... revised section 173.167 for consistency with the ICAO TI. Specifically, the amendments were intended to... of the ICAO TI applicable to consumer commodities prepared and intended for transportation...

  8. Effect of Notch -1 gene uprugulation on AKT -mTOR signal of U251 cell%上调 Notch-1基因对 U215细胞 AKT -mTOR 通路的影响

    Institute of Scientific and Technical Information of China (English)

    楚可新; 戴明明; 林勤; 赵能江

    2016-01-01

    Objective:To investigate the effect of Notch -1 gene up -regulation on biological hehaviors of U215 cell and explore its effects on AKT -mTOR signal.Methods:U251 cells were infected with over -expression NICD or control lentivirus,the mRNA and protein expression of Notch -1 gene were examined with RT -PCR and Western -Blot,the cell proliferation was assayed with MTT,cell cycle was determined by flow cytometry,the effects of Notch -1 gene on U251 cell invasion were studied using matrigel coated Transwell chambers,the effects of Notch -1 up -gula-tion on AKT,mTOR,P70S6K and 4Ebp -1 protein expression were also analyzed.Results:Compared with the un-treated and empty group,after 72h of infection,the protein and mRNA expression of Notch -1 increased(P <0.05). It was found that up -regulation of Notch -1 promoted U251 cell growth,invasion and S -phase cells were increased (P <0.05).Up -regulation of Notch -1 promoted Cyclin D1,CDK -4 protein expression,and p -AKT and p -mTOR also increased in Notch -1 up -regulated U251 cells.Conclusion:Up -regulation Notch -1 promotes U251 glioma cell proliferation and invasion,the mechanism was partly through regulating AKT -mTOR signaling.%目的:观察上调 Notch -1基因对人胶质瘤 U251细胞生学物行为及 AKT -mTOR 信号通路的影响。方法:采用 pNL -NICD 慢病毒感染 U251细胞,以 RT -PCR 和 Western -Blot 检测 Notch -1基因 mRNA 和蛋白的表达,以 MTT 检测细胞增殖能力,流式细胞术检测细胞周期变化,Transwell 实验检测细胞侵袭能力,同时检测 Notch -1上调对 AKT、mTOR、P70S6K、4Ebp -1蛋白的影响。结果:与对照组比较,NICD 慢病毒转染72h后,Notch -1基因 mRNA 和蛋白表达明显增高(P <0.01);Notch -1上调明显促进 U251细胞增殖、侵袭、促进细胞进入 S 期,增加周期蛋白 Cyclin D1、CDK -4的表达,促进 AKT、mTOR 蛋白磷酸化。结论:上调 Notch -1基因促进 U251细

  9. 2 CFR 1326.215 - Which nonprocurement transactions, in addition to those listed in 2 CFR 180.215, are not covered...

    Science.gov (United States)

    2010-01-01

    ... Promotion, Trade Information and Counseling, and Trade policy. (2) Geodetic Surveys and Services (Specialized Services). (3) Fishery Products Inspection Certification. (4) Standard Reference Materials. (5... Data System. (8) The sale or provision of products, information, and services to the general public....

  10. 2 CFR 215.12 - Forms for applying for Federal assistance.

    Science.gov (United States)

    2010-01-01

    ... application was subject to review by the State Single Point of Contact (SPOC). The name and address of the SPOC for a particular State can be obtained from the Federal awarding agency or the Catalog of Federal Domestic Assistance. The SPOC shall advise the applicant whether the program for which application is...

  11. 48 CFR 52.215-1 - Instructions to Offerors-Competitive Acquisition.

    Science.gov (United States)

    2010-10-01

    ... withdrawal of proposals. (1) Unless other methods (e.g., electronic commerce or facsimile) are permitted in... transmitted through an electronic commerce method authorized by the solicitation, it was received at the... numbers of the offeror (and electronic address if available); (iii) A statement specifying the extent...

  12. The Ultraviolet Photoelectron Spectroscopy of Group IV 2-15 Atom Cluster Anions

    Science.gov (United States)

    Craycraft, Mary Jo.

    The ability to map valence electronic structure is the result of a recent advance in photoelectron spectroscopy; its union with cluster molecular beam technology. The task of interpreting the spectra is hampered by a serious lack of understanding of cluster electronic structure in general. Recently progress has been made in finding models for single s valence electron systems. Alkali and noble metal clusters can be treated as free electron systems and simple interatomic potentials can be used with rare gas clusters. Neither a smeared jellium background nor a simple interatomic potential is adequate to describe covalent bonding, however. The isoelectronic Group IV members have a valence configuration of ns^2 np^2. All readily form clusters, and the elements differ in both their atomic and bulk properties; thus the series provides an ideal system for studying electronic structure. The mass selected cluster ion beam is crossed with a beam (6.42 or 7.9eV) and the resulting photodetached electrons collected with the aid of judiciously arranged magnetic fields. The spectra are found to be unique for each size cluster. Some spectra show a significant gap between the two lowest binding energy features, indicating that the neutral cluster is a closed shell species. The clusters with such gaps are minima in a plot of EA as a function of cluster size. The UPS also vary with the cluster composition. Carbon is unique; an even -odd alternation in electron affinities switches from odd minima for clusters containing less than ten atoms to odd maxima for larger clusters. This corresponds with an alternation in singlet and triplet ground states and a switch from chain to ring structures previously predicted by theory (K. S. Pitzer, E. Clementi, J. Amer. Chem. Soc. 81 4477 (1958) and R. Hoffmann, Tetrahedron 22 521 (1965)). The spectra of the remaining group IV members are remarkably similar to each other for clusters of up to ten atoms, as is the trend in the electron affinities as a function of cluster size. This similarity in electronic structure may imply similarity in geometries. At ten, Si and Ge behavior diverges from that of Sn and Pb.

  13. Basic Chemical Precipitation Softening. Training Module 2.215.2.77.

    Science.gov (United States)

    McMullen, L. D.

    This document is an instructional module package prepared in objective form for use by an instructor familiar with chemical precipitation softening. Included are objectives, an instructor guide, student handouts and transparency masters. This is the first level of a three module series and is designed for students with little or no operating…

  14. 75 FR 32440 - Catalog of Federal Domestic Assistance (CFDA) Number: 84.215J

    Science.gov (United States)

    2010-06-08

    ... academic, social, and emotional development can contribute to the child's long-term economic and social... children's learning. Services and activities coordinated or provided by the FSCS should be based on... important in ensuring the healthy physical development of a child and his or her academic...

  15. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (215-0611-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  16. 7 CFR 215.12 - Claims against schools or child-care institutions.

    Science.gov (United States)

    2010-01-01

    ... matter in connection with this section to FNSRO and CND for determination of the action to be taken. (d... audit. (e) If CND does not concur with the State Agency action in paying a claim or a reclaim, or in... submit to CND evidence or information concerning the action taken. If in the determination of CND,...

  17. Towards the Ictalurid Catfish Transcriptome: Generation and Analysis of 31,215 Catfish ESTs.

    OpenAIRE

    Dunham Rex; Muir William; Liu Lei; Turan Cemal; Simmons Micah; Serapion Jerry; Somridhivej Benjaporn; Nandi Samiran; Kucuktas Huseyin; Xu Peng; Baoprasertkul Puttharat; He Chongbo; Feng Jinian; Wang Shaolin; Peatman Eric

    2007-01-01

    Abstract Background EST sequencing is one of the most efficient means for gene discovery and molecular marker development, and can be additionally utilized in both comparative genome analysis and evaluation of gene duplications. While much progress has been made in catfish genomics, large-scale EST resources have been lacking. The objectives of this project were to construct primary cDNA libraries, to conduct initial EST sequencing to generate catfish EST resources, and to obtain baseline inf...

  18. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (215-0611-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  19. P2-15: EEG Analysis on Story Change in TV Drama

    Directory of Open Access Journals (Sweden)

    Chung-Yeon Lee

    2012-10-01

    Full Text Available The human brain naturally recognizes a change of environment or atmosphere without great effort, and this is essential for interactive communication in social life and a specific reaction in an emergency situation. Most studies have investigated change detection of the brain with conditional experimental paradigms rather than the performance of everyday tasks. However, naturally occurring sensory stimuli are multimodal and dynamic. In an effort to study the relationship between users' induced physiological responses and changes of environment and atmosphere under more naturalistic and ecological conditions, we performed a basic experiment using audio-visual movies and electroencephalogram (EEG measurement. 8 healthy subjects were asked to watch a television sitcom without any responses, and their EEG signals were recorded simultaneously with 126 electrodes mounted in an elastic electrode cap. Time-frequency analysis of EEG revealed distinctive neural oscillations at the point of story change in the movie. This result could be used for applications in brain-computer interfaces, and provides a reference to cognitive impairment studies such as Attention Deficit Disorder (ADD or Attention-Deficit/Hyperactivity Disorder (ADHD.

  20. 29 CFR 780.215 - Meaning of forestry or lumbering operations.

    Science.gov (United States)

    2010-07-01

    ... management of forests, the felling and trimming of timber, the cutting, hauling, and transportation of timber... employees are employed.) Wood working as such is not included in forestry or lumbering operations....

  1. 48 CFR 52.215-23 - Limitations on Pass-Through Charges.

    Science.gov (United States)

    2010-10-01

    ... clause: Limitations on Pass-Through Charges (OCT 2009) (a) Definitions. As used in this clause— Added... pricing data in accordance with FAR 15.403-4. (End of clause) Alternate I (OCT 2009). As prescribed in...

  2. 20 CFR 498.215 - The hearing and burden of proof.

    Science.gov (United States)

    2010-04-01

    ... burden of going forward and the burden of persuasion with respect to affirmative defenses and any... persuasion with respect to all other issues. (c) The burden of persuasion will be judged by a...

  3. 49 CFR Appendix B to Part 215 - Schedule of Civil Penalties 1

    Science.gov (United States)

    2010-10-01

    ... ridge; a depression; a circumferential score; corrugation; a scratch; a continuous streak; pitting; rust....305Stencilling of maintenance-of-way 1,000 2,000 1 A penalty may be assessed against an individual only for a... will be treated as a violation separate and distinct from, and in addition to, any...

  4. 34 CFR 685.215 - Discharge for false certification of student eligibility or unauthorized payment.

    Science.gov (United States)

    2010-07-01

    ... Direct Loan as a result of the crime of identity theft committed against the individual, as that crime is... accrued charges and collection costs with respect to the loan. (2) Discharge for unauthorized payment... falsely certified because he or she was a victim of the crime of identity theft and is requesting...

  5. 48 CFR 1552.215-72 - Instructions for the Preparation of Proposals.

    Science.gov (United States)

    2010-10-01

    ... uncompensated overtime, the offeror must propose a methodology that is consistent with their cost accounting.... Indicate the amount of unallowable costs included in the historical data. (iv) Offerors who propose... cost, in accordance with the offeror's accounting system, those costs should not be included as...

  6. XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation

    DEFF Research Database (Denmark)

    Mortuza, Gulnahar B.; Cavazza, Tommaso; Garcia-Mayoral, Maria Flor;

    2014-01-01

    chTOG is a conserved microtubule polymerase that catalyses the addition of tubulin dimers to promote microtubule growth. chTOG interacts with TACC3, a member of the transforming acidic coiled-coil (TACC) family. Here we analyse their association using the Xenopus homologues, XTACC3 (TACC3) and XM...

  7. 48 CFR 215.404-71-3 - Contract type risk and working capital adjustment.

    Science.gov (United States)

    2010-10-01

    ... normal value when the contract type risk is low. Indicators of this are— (i) Very mature product line... paragraph (c) of this subsection using the evaluation criteria in paragraph (d) of this subsection. (2... provisions for performance-based payments, do not compute a working capital adjustment. (d)...

  8. 7 CFR 215.13a - Determining eligibility for free milk in child-care institutions.

    Science.gov (United States)

    2010-01-01

    ... AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SPECIAL MILK PROGRAM FOR... substantially like that outlined in part 245 of this chapter. (5) An assurance that there will be no... include persons responsible for carrying out program requirements and monitoring, reviewing, auditing,...

  9. 24 CFR 598.215 - What are the purpose and content of the strategic plan?

    Science.gov (United States)

    2010-04-01

    ... community should utilize modern communication techniques and incorporate the Internet in order to enhance..., technical, human, cultural, educational, leadership, volunteerism, communications, transportation and... include developable sites, a plan to describe how the use of these parcels would benefit residents...

  10. 33 CFR 106.215 - Company or OCS facility personnel with security duties.

    Science.gov (United States)

    2010-07-01

    ... appropriate: (a) Knowledge of current and anticipated security threats and patterns. (b) Recognition and... screenings of persons, personal effects, stores and industrial supplies; (k) Familiarity with all...

  11. 40 CFR 94.215 - Maintenance of records; submittal of information; right of entry.

    Science.gov (United States)

    2010-07-01

    ... certification, filed with the Administrator. (2) Individual records. (i) A brief history of each engine used for... engine or emission control system performance, giving the date and time of the test and the reason for it. (E) A brief description of any significant events affecting the engine during the period covered...

  12. 48 CFR 52.215-10 - Price Reduction for Defective Certified Cost or Pricing Data.

    Science.gov (United States)

    2010-10-01

    ... complete, accurate, and current as certified in its Certificate of Current Cost or Pricing Data; (2) A... complete, accurate, and current as certified in the Contractor's Certificate of Current Cost or Pricing... been modified even if accurate, complete, and current certified cost or pricing data had been...

  13. Cancer during pregnancy: an analysis of 215 patients emphasizing the obstetrical and the neonatal outcomes.

    NARCIS (Netherlands)

    Calsteren, K. van; Heyns, L.; Smet, F. De; Eycken, L. Van; Gziri, M.M.; Gemert, W. Van; Halaska, M.; Vergote, I.; Ottevanger, N.; Amant, F.

    2010-01-01

    PURPOSE: The aim of this study was to assess the management and the obstetrical and neonatal outcomes of pregnancies complicated by cancer. PATIENTS AND METHODS: In an international collaborative setting, patients with invasive cancer diagnosed during pregnancy between 1998 and 2008 were identified.

  14. PS2-15: Coding for Obesity in a Health Plan Claims Database

    OpenAIRE

    Shainline, Michael; Carter, Shelley; Von Worley, Ann; Gunter, Margaret

    2010-01-01

    Background and Aims: The Centers for Disease Control estimated the obesity rate in New Mexico for 2008 to be 25.2%. Sources estimate the following associations between obesity and type 2 diabetes (80%); cardiovascular disease (70%); hypertension (26 %). Yet obesity is infrequently coded as a secondary diagnosis among providers submitting claims. This study examines the frequency with which obesity is documented on claims forms, the relationship between age, gender, and obesity coding, and the...

  15. 40 CFR 80.215 - What is the scope of the geographic phase-in program?

    Science.gov (United States)

    2010-07-01

    ... Sioux Nevada Elko Eureka Humboldt Lander Lincoln White Pine Oregon Baker Crook Gilliam Grant Harney..., and Alaska. (2) In addition, the following counties within the states identified in paragraph (a)(2)(i... are included in the GPA: (i) The list of counties follows: Arizona Apache Coconino Gila...

  16. 9 CFR 381.215 - Poultry or other articles subject to judicial seizure and condemnation.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Poultry or other articles subject to... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION...

  17. 32 CFR 215.9 - Providing military resources to civil authorities.

    Science.gov (United States)

    2010-07-01

    ... the handling of requests for DoD facilities, personnel, equipment, or supplies, received from... respective military departments. (ii) The Director, Defense Supply Agency, is authorized to approve requests... renewal of outstanding loans, may be denied at any level in the chain of command down to and...

  18. 48 CFR 1552.215-73 - General financial and organizational information.

    Science.gov (United States)

    2010-10-01

    ...: Auditor: (f)(1) Work Distribution for the Last Completed Fiscal Accounting Period: Sales: Government cost... cost Standard cost Estimating System: Job Order ___ ___ Process ___ ___ Accumulating System: Job...

  19. 47 CFR 73.215 - Contour protection for short-spaced assignments.

    Science.gov (United States)

    2010-10-01

    ... station pursuant to 47 CFR 73.211(b)(3): 6 kW ERP/240 meters HAAT—Class A 25 kW ERP/150 meters HAAT—Class B1 50 kW ERP/472 meters HAAT—Class B (b) Applicants requesting short-spaced assignments pursuant to... achieved: (1) The ERP and antenna HAAT of the proposed station in the direction of the contours of...

  20. 妊娠高血压疾病的母婴结局-附215例临床分析%The Outcomes of the Mother and Infants in Hypertension of Pregnancy-215 cases are attached

    Institute of Scientific and Technical Information of China (English)

    李树英; 梁玉兰; 王沂峰

    2006-01-01

    目的探讨降低妊娠高血压疾病患者母婴并发症的预防措施.方法对我院2000年1月至2004年12月收治的妊娠高血压疾病患者作回顾性分析.结果妊娠高血压疾病患者母婴并发症的发生率均高于正常妊娠.结论加强围产期保健,妊娠中期开展妊娠高血压疾病预测性诊断,可预防或减轻妊娠高血压疾病的发生,开展产前诊断,及时终止妊娠,可降低妊娠高血压疾病患者母婴并发症.

  1. Neutron-diffraction study of stripe order in La2NiO4+δ with δ=215

    Science.gov (United States)

    Wochner, P.; Tranquada, J. M.; Buttrey, D. J.; Sachan, V.

    1998-01-01

    We report a detailed neutron-scattering study of the ordering of spins and holes in oxygen-doped La2NiO4.133. The single-crystal sample exhibits the same oxygen-interstitial order but better defined charge-stripe order than that studied previously in crystals with δ=0.125. In particular, charge order is observed up to a temperature at least twice that of the magnetic transition, Tm=110.5 K. On cooling through Tm, the wave vector ɛ, equal to half the charge-stripe density within an NiO2 layer, jumps discontinuously from 13 to 0.2944. It continues to decrease with further cooling, showing several lock-in transitions on the way down to low temperature. To explain the observed lock-ins, a model is proposed in which each charge stripe is centered on either a row of Ni or a row of O ions. The model is shown to be consistent with the l dependence of the magnetic peak intensities and with the relative intensities of the higher-order magnetic satellites. Analysis of the latter also provides evidence that the magnetic domain walls (charge stripes) are relatively narrow. In combination with a recent study of magnetic-field-induced effects, we find that the charge stripes are all O centered at T>Tm, with a shift towards Ni centering at T

  2. Oahu Hyperspectral Imagery 2000 (215-0611-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  3. Synthetic aperture acoustic imaging of canonical targets with a 2-15 kHz linear FM chirp

    Science.gov (United States)

    Vignola, Joseph F.; Judge, John A.; Good, Chelsea E.; Bishop, Steven S.; Gugino, Peter M.; Soumekh, Mehrdad

    2011-06-01

    Synthetic aperture image reconstruction applied to outdoor acoustic recordings is presented. Acoustic imaging is an alternate method having several military relevant advantages such as being immune to RF jamming, superior spatial resolution, capable of standoff side and forward-looking scanning, and relatively low cost, weight and size when compared to 0.5 - 3 GHz ground penetrating radar technologies. Synthetic aperture acoustic imaging is similar to synthetic aperture radar, but more akin to synthetic aperture sonar technologies owing to the nature of longitudinal or compressive wave propagation in the surrounding acoustic medium. The system's transceiver is a quasi mono-static microphone and audio speaker pair mounted on a rail 5meters in length. Received data sampling rate is 80 kHz with a 2- 15 kHz Linear Frequency Modulated (LFM) chirp, with a pulse repetition frequency (PRF) of 10 Hz and an inter-pulse period (IPP) of 50 milliseconds. Targets are positioned within the acoustic scene at slant range of two to ten meters on grass, dirt or gravel surfaces, and with and without intervening metallic chain link fencing. Acoustic image reconstruction results in means for literal interpretation and quantifiable analyses. A rudimentary technique characterizes acoustic scatter at the ground surfaces. Targets within the acoustic scene are first digitally spotlighted and further processed, providing frequency and aspect angle dependent signature information.

  4. 20 CFR 645.215 - What must a WtW operating entity that serves noncustodial parent participants do?

    Science.gov (United States)

    2010-04-01

    ... and children who may be at risk of domestic violence, the operating entity must consult with domestic... commitment by the noncustodial parent to cooperate in the payment of child support for the minor child. This... related activities that will enable the noncustodial parent to make regular child support payments....

  5. Regional cerebral blood flow during light sleep--a H(2)(15)O-PET study

    DEFF Research Database (Denmark)

    Kjaer, Troels W; Law, Ian; Wiltschiøtz, Gordon

    2002-01-01

    there was a relative flow increase in the occipital lobes and a relative flow decrease in the bilateral cerebellum, the bilateral posterior parietal cortex, the right premotor cortex and the left thalamus. Hypnagogic experiences seemed not to be associated with any relative flow changes. The topography...... of the occipital activation during stage-1 sleep supports a hypothesis of this state being a state of imagery. The rCBF decreases in premotor cortex, thalamus and cerebellum could be indicative of a general decline in preparedness for goal directed action during stage-1 sleep. Stage-1 sleep seems more similar...

  6. Mejoras en la exactitud del reloj de ángulo horario del telescopio de 2,15 mts de CASLEO

    Science.gov (United States)

    Aballay, J. L.; Pereyra, P. F.; Marún, A. H.

    Para aumentar la exactitud en el control del ángulo horario del telescopio, se está implementando el uso de un reloj con una precisión de 1/100 seg. En conjunto con el encoder que otorga la posición con un acierto de 0,012 seg. de arco, se podrá implementar otro dígito en el reloj de ángulo horario con la posibilidad de ver las décimas. Esto, sumado a la precisión ya lograda en declinación, permitirá realizar offsets con mayor exactitud.

  7. 22 CFR 215.10 - Disclosure of record to person other than the individual to whom it pertains.

    Science.gov (United States)

    2010-04-01

    ... adequate advance written assurance that the record will be used solely as a statistical research or... the United States for a civil or criminal law enforcement activity authorized by law: Provided,...

  8. Characterization of acid flux in osteoclasts from patients harboring a G215R mutation in ClC-7

    DEFF Research Database (Denmark)

    Henriksen, Kim; Gram, Jeppe; Neutzsky-Wulff, Anita Vibsig

    2008-01-01

    The chloride-proton antiporter ClC-7 has been speculated to be involved in acidification of the lysosomes and the resorption lacunae in osteoclasts; however, neither direct measurements of chloride transport nor acidification have been performed. Human osteoclasts harboring a dominant negative...

  9. 48 CFR 52.215-11 - Price Reduction for Defective Certified Cost or Pricing Data-Modifications.

    Science.gov (United States)

    2010-10-01

    ... subcontractor furnished certified cost or pricing data that were not complete, accurate, and current as certified in its Certificate of Current Cost or Pricing Data, (2) a subcontractor or prospective... current as certified in the Contractor's Certificate of Current Cost or Pricing Data, or (3) any of...

  10. 12 CFR Appendix to Part 215 - Section 5200 of the Revised Statutes Total Loans and Extensions of Credit

    Science.gov (United States)

    2010-01-01

    ...— (1) The term loans and extensions of credit shall include all direct or indirect advances of funds to... the Currency, such term shall also include any liability of a national banking association to advance... discount by dealers in dairy cattle of paper given in payment for dairy cattle, which paper carries a...

  11. Oahu Hyperspectral Imagery 2000 (215-0611-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  12. 76 FR 39378 - Foreign-Trade Zone 215-Sebring, FL; Application for Reorganization Under Alternative Site Framework

    Science.gov (United States)

    2011-07-06

    ... being requested at this time. In accordance with the Board's regulations, Kathleen Boyce of the FTZ..., contact Kathleen Boyce at Kathleen.Boyce@trade.gov or (202) 482-1346. Dated: June 29, 2011. Andrew...

  13. 日本Seta高尔夫球场 第6洞,Par3,215

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    开球区前面的右侧是又大又宽阔的水池,能让人心理上产生压力,不过从右边的边缘到水池只有25码,所以除非有重大失误,一般是不会失打的。可以不用在意,放心大胆地击球。球场左边有森林,如果不小心飞了进去,就算作出界,所以果岭四周设有防护,曲折蜿蜒也是球场非常大的特点之一。

  14. 16 CFR 2.15 - Orders requiring witnesses to testify or provide other information and granting immunity.

    Science.gov (United States)

    2010-01-01

    ... Bureaus of Competition and Economics, the Bureau Director, Deputy Directors and Associate Directors of the... essential to serve the interests of justice. Such appeals shall be made on the record and shall be in...

  15. Equilibrium geometries and electronic properties of BenLi(n=2-15)clusters from first principles

    Institute of Scientific and Technical Information of China (English)

    Lei Xue-Ling; Zhu Heng-Jiang; Wang Xian-Ming; Luo You-Hua

    2008-01-01

    This paper studies the equilibrium geometries and electronic properties of Ben and BenLi clusters,up to n=15,by using density-functional theory(DFT)at B3LYP/6-31G(d)level.The lowest-energy structures of Ben and BenLi clusters were determined.The results indicate that a single lithium impurity enhances the stability and chemical reactivity of the beryllium clusters.It finds that the geometries of the host clusters change significantly after the addition of the lithium atom for n≥8.The lithium impurity prefers to be on the periphery of beryllium clusters,and occupies vertex sites.Both Be4Li,Be9Li,and Be13Li were found to be particularly stable with higher average binding energy,local peaks of second-order energy difference and fragmentation energies.For all the BenLi clusters studied,we found charge transfers from the Li to Be site and co-existence of covalent and metallic bonding characteristics.

  16. SU-E-J-215: Towards MR-Only Image Guided Identification of Calcifications and Brachytherapy Seeds: Application to Prostate and Breast LDR Implant Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Elzibak, A; Fatemi-Ardekani, A; Soliman, A; Mashouf, S; Safigholi, H; Ravi, A; Morton, G; Song, WY [Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Han, D [Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); University of California, San Diego, La Jolla, CA (United States)

    2015-06-15

    Purpose: To identify and analyze the appearance of calcifications and brachytherapy seeds on magnitude and phase MRI images and to investigate whether they can be distinguished from each other on corrected phase images for application to prostate and breast low dose rate (LDR) implant dosimetry. Methods: An agar-based gel phantom containing two LDR brachytherapy seeds (Advantage Pd-103, IsoAid, 0.8mm diameter, 4.5mm length) and two spherical calcifications (large: 7mm diameter and small: 4mm diameter) was constructed and imaged on a 3T Philips MR scanner using a 16-channel head coil and a susceptibility weighted imaging (SWI) sequence (2mm slices, 320mm FOV, TR/ TE= 26.5/5.3ms, 15 degree flip angle). The phase images were unwrapped and corrected using a 32×32, 2D Hanning high pass filter to remove background phase noise. Appearance of the seeds and calcifications was assessed visually and quantitatively using Osirix (http://www.osirix-viewer.com/). Results: As expected, calcifications and brachytherapy seeds appeared dark (hypointense) relative to the surrounding gel on the magnitude MRI images. The diameter of each seed without the surrounding artifact was measured to be 0.1 cm on the magnitude image, while diameters of 0.79 and 0.37 cm were measured for the larger and smaller calcifications, respectively. On the corrected phase images, the brachytherapy seeds and the calcifications appeared bright (hyperintense). The diameter of the seeds was larger on the phase images (0.17 cm) likely due to the dipole effect. Conclusion: MRI has the best soft tissue contrast for accurate organ delineation leading to most accurate implant dosimetry. This work demonstrated that phase images can potentially be useful in identifying brachytherapy seeds and calcifications in the prostate and breast due to their bright appearance, which helps in their visualization and quantification for accurate dosimetry using MR-only. Future work includes optimizing phase filters to best identify and delineate seeds and calcifications.

  17. Reciprocal Benefits of Mass-Univariate and Multivariate Modeling in Brain Mapping: Applications to Event-Related Functional MRI, H215O-, and FDG-PET

    Directory of Open Access Journals (Sweden)

    James R. Moeller

    2006-01-01

    Full Text Available In brain mapping studies of sensory, cognitive, and motor operations, specific waveforms of dynamic neural activity are predicted based on theoretical models of human information processing. For example in event-related functional MRI (fMRI, the general linear model (GLM is employed in mass-univariate analyses to identify the regions whose dynamic activity closely matches the expected waveforms. By comparison multivariate analyses based on PCA or ICA provide greater flexibility in detecting spatiotemporal properties of experimental data that may strongly support alternative neuroscientific explanations. We investigated conjoint multivariate and mass-univariate analyses that combine the capabilities to (1 verify activation of neural machinery we already understand and (2 discover reliable signatures of new neural machinery. We examined combinations of GLM and PCA that recover latent neural signals (waveforms and footprints with greater accuracy than either method alone. Comparative results are illustrated with analyses of real fMRI data, adding to Monte Carlo simulation support.

  18. Broad spectrum of in vivo fitness of human immunodeficiency virus type 1subpopulations differing at reverse transcriptase codons 41 and 215

    NARCIS (Netherlands)

    Goudsmit, J.; Ronde, A. de; Rooij, E. de; Boer, R.J. de

    1997-01-01

    Viral populations in a human immunodeficiency virus type 1 (HIV-1)-infected individual behave as a quasispecies with a rated distribution of fitness variants. Fitness distributions in naturally occurring viral populations have been difficult to study due to the lack of markers for individual virus c

  19. Comparative Spectra of Oxygen-Rich vs. Carbon-Rich Circumstellar Shells: VY Canis Majoris and IRC+10216 at 215-285 GHz

    CERN Document Server

    Tenenbaum, E D; Milam, S N; Woolf, N J; Ziurys, L M

    2010-01-01

    A sensitive (1{\\sigma} rms at 1 MHz resolution ~3 mK) 1 mm spectral line survey (214.5-285.5 GHz) of VY Canis Majoris (VY CMa) and IRC+10216 has been conducted to compare the chemistries of oxygen and carbon-rich circumstellar envelopes. This study was carried out using the Submillimeter Telescope (SMT) of the Arizona Radio Observatory (ARO) with a new ALMA-type receiver. This survey is the first to chemically characterize an O-rich circumstellar shell at millimeter wavelengths. In VY CMa, 128 emission features were detected arising from 18 different molecules, and in IRC+10216, 720 lines were observed, assigned to 32 different species. The 1 mm spectrum of VY CMa is dominated by SO2 and SiS; in IRC +10216, C4H and SiC2 are the most recurrent species. Ten molecules were common to both sources: CO, SiS, SiO, CS, CN, HCN, HNC, NaCl, PN, and HCO+. Sulfur plays an important role in VY CMa, but saturated/unsaturated carbon dominates the molecular content of IRC+10216, producing CH2NH, for example. Although the mol...

  20. Phylogeographic Analysis of Haplogroup E3b (E-M215) Y Chromosomes Reveals Multiple Migratory Events Within and Out Of Africa

    Science.gov (United States)

    Cruciani, Fulvio; La Fratta, Roberta; Santolamazza, Piero; Sellitto, Daniele; Pascone, Roberto; Moral, Pedro; Watson, Elizabeth; Guida, Valentina; Colomb, Eliane Beraud; Zaharova, Boriana; Lavinha, João; Vona, Giuseppe; Aman, Rashid; Calì, Francesco; Akar, Nejat; Richards, Martin; Torroni, Antonio; Novelletto, Andrea; Scozzari, Rosaria

    2004-01-01

    We explored the phylogeography of human Y-chromosomal haplogroup E3b by analyzing 3,401 individuals from five continents. Our data refine the phylogeny of the entire haplogroup, which appears as a collection of lineages with very different evolutionary histories, and reveal signatures of several distinct processes of migrations and/or recurrent gene flow that occurred in Africa and western Eurasia over the past 25,000 years. In Europe, the overall frequency pattern of haplogroup E-M78 does not support the hypothesis of a uniform spread of people from a single parental Near Eastern population. The distribution of E-M81 chromosomes in Africa closely matches the present area of distribution of Berber-speaking populations on the continent, suggesting a close haplogroup–ethnic group parallelism. E-M34 chromosomes were more likely introduced in Ethiopia from the Near East. In conclusion, the present study shows that earlier work based on fewer Y-chromosome markers led to rather simple historical interpretations and highlights the fact that many population-genetic analyses are not robust to a poorly resolved phylogeny. PMID:15042509

  1. Prime Contract Awards of $100,000 or More by Federal Supply Classification or Service Category and Purchasing Office, FY 88. Part 5. (S215-Z299).

    Science.gov (United States)

    1988-01-01

    4 N 00 ( AccA % 0 4 00.-.0-..4 V 41 0 -C 0 00 ~I-" . 0( rU 4c 04 w Of0"al-t c - 9-0 0 -C I.-n 0.O .- O (𔃻 30- ----- -------- - 00 N4-4 0 -4 Nj~cU -Io...004 :1- & 4 .. JOZ- 0 d0 I. <-i4 << 0ម I.-CL cc 4 C.20.0 z I hI >U0 x 0 < zC 0 0 r 4I ""mI- P1 -hh I- hiJZ hi x "m _ito -J0 auJ -J.j z _ . U) 0 1-N 0

  2. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Science.gov (United States)

    2010-01-01

    ... Category 1(TBq) Category 1(Ci) Category 2(TBq) Category 2(Ci) Actinium-227 20 540 0.2 5.4 Americium-241 60... 2 54 Strontium-90 1,000 27,000 10 270 Thorium-228 20 540 0.2 5.4 Thorium-229 20 540 0.2 5.4...

  3. Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.

    Science.gov (United States)

    Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R; Wai, Chien M

    1999-09-01

    A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

  4. I. The metabolic properties of plutonium and allied materials

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  5. Neutron Flux Depression in the UO{sub 2}-PuO{sub 2}(15 to 30%) Fuel Rods from IVO-FR2-Vg7-Irradiation Experiment; Depresion de flujo neutronico en las barras combustibles de UO2-PuO2(15 al 30%) del experimento de irradiacion IVO-FR2-Vg7

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, J.; Fernandez, J. L.

    1983-07-01

    The thermal-neutron flux depression within a fuel rod has a great influence in the radial temperature profile of the rod, especially for high enrichment fuel. For this reason, a study was made about the UO{sub 2}-PUO{sub 2} (15 to 30% PUO{sub 2}) fuel pins for the KfK-JEN joint irradiation program IVO, in the FR2 reactor. Different methods (diffusion, Bonalumi, successive generations) were compared and a new approach (parabolic approximation) was developed. (Author) 22 refs.

  6. Efeito da implantação de rodovias no cerrado brasileiro sobre a fauna de vertebrados - DOI: 10.4025/actascibiolsci.v28i3.215 Effect of the implantation of roads in the brazilian cerrado on the fauna of vertebrates - DOI: 10.4025/actascibiolsci.v28i3.215

    Directory of Open Access Journals (Sweden)

    Zara Faria Sobrinha Guimarães

    2007-11-01

    Full Text Available A fragmentação de hábitat causada pela ação humana vem sendo um dos grandes desafios para a biologia da conservação. A construção de estradas é um mecanismo de fragmentação de alto impacto, removendo a cobertura vegetal original, gerando efeito de borda e alterando a função e estrutura da paisagem, em contraste com a necessidade e o alto valor econômico imposto pela sociedade humana. Neste sentido, este estudo teve como objetivo avaliar o impacto da estrada na comunidade de fauna silvestre do Parque Altamiro de Moura Pacheco associada à presença da rodovia (BR-153/GO-060. Durante um ano de pesquisa, foram registrados 141 animais mortos por atropelamento. Os resultados do presente estudo, conduzido de Agosto/2003 a Julho/2004, foram comparados e analisados com estudo feito entre os anos de 1996 e 1997, tanto ao nível de carcaças encontradas quanto ao nível de ambiente. De acordo com os dados apresentados, reforça-se a necessidade de haver um melhor planejamento ao construir estradas, principalmente próximos a ambientes preservados ou unidades de conservação.The fragmentation of habitat caused by the action human being is comes one of the great challenges for the biology of the conservation. The construction of roads is a mechanism of the fragmentation of high impact, removing the original vegetablel covering, generating edge effect and modifying the function and structure of the landscape, in contrast with the necessity and the high economic value tax for the society human being. In this direction, this study it had as objective to evaluate the impact of the road in the community of wild fauna of the Park Altamiro de Moura Pacheco associated with the presence of the road (BR-153/GO-060. During one year of research, they had been registered 141 animals died for running over The results of the present study, lead of Agosto/2003 the Julho/2004, had been compared and analyzed with made study it enters the years of 1996 and 1997, as much the level of finded species how much the environment level. In accordance with the presented data, it is strengthened necessity to have one better planning when constructing roads, mainly next the preserved environments or units to conservation.

  7. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  8. Behaviour of uranium series radionuclides in surface water (Crouzille, Limousin). Geochemical implications; Comportement des radionucleides des familles de l'uranium dans les eaux superficielles du site de la Crouzille (Limousin): implications geochimiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-06-15

    Understanding natural radionuclides behaviour in surface water is a required step to achieve uranium mine rehabilitation and preserve water quality. The first objective of this thesis is to determine which are the radionuclides sources in a drinking water reservoir. The second objective is to improve the knowledge about the behaviour of uranium series radionuclides, especially actinium. The investigated site is a brook (Sagnes, Limousin, France) which floods a peat bog contaminated by a former uranium mine and which empties into the Crouzille lake. It allows studying radionuclides transport in surface water and radionuclides retention through organic substance or water reservoir. Radionuclides distribution in particulate, colloidal and dissolved phases is determined thanks to ultra-filtrations. Gamma spectrometry allows measuring almost all natural radionuclides with only two counting stages. However, low activities of {sup 235}U series radionuclides impose the use of very low background well-type Ge detectors, such as those of the Underground Laboratory of Modane (France). Firstly, this study shows that no or few radionuclides are released by the Sagnes peat bog, although its radioactivity is important. Secondly, it provides details on the behaviour of uranium series radionuclides in surface water. More specifically, it provides the first indications of actinium solubility in surface water. Actinium's behaviour is very close to uranium's even if it is a little less soluble. (author)

  9. 12 CFR 337.3 - Limits on extensions of credit to executive officers, directors, and principal shareholders of...

    Science.gov (United States)

    2010-01-01

    ... principal shareholders of insured nonmember banks. (a) With the exception of 12 CFR 215.5(b), 215.5(c)(3... A of Federal Reserve Board Regulation O (12 CFR part 215, subpart A) to the same extent and to the... Regulation O (12 CFR 215.2(f)). (c)(1) No insured nonmember bank may extend credit in an aggregate...

  10. Classic 18.5- and 21.5-kDa myelin basic protein isoforms associate with cytoskeletal and SH3-domain proteins in the immortalized N19-oligodendroglial cell line stimulated by phorbol ester and IGF-1.

    Science.gov (United States)

    Smith, Graham S T; Homchaudhuri, Lopamudra; Boggs, Joan M; Harauz, George

    2012-06-01

    The 18.5-kDa classic myelin basic protein (MBP) is an intrinsically disordered protein arising from the Golli (Genes of Oligodendrocyte Lineage) gene complex and is responsible for compaction of the myelin sheath in the central nervous system. This MBP splice isoform also has a plethora of post-translational modifications including phosphorylation, deimination, methylation, and deamidation, that reduce its overall net charge and alter its protein and lipid associations within oligodendrocytes (OLGs). It was originally thought that MBP was simply a structural component of myelin; however, additional investigations have demonstrated that MBP is multi-functional, having numerous protein-protein interactions with Ca²⁺-calmodulin, actin, tubulin, and proteins with SH3-domains, and it can tether these proteins to a lipid membrane in vitro. Here, we have examined cytoskeletal interactions of classic 18.5-kDa MBP, in vivo, using early developmental N19-OLGs transfected with fluorescently-tagged MBP, actin, tubulin, and zonula occludens 1 (ZO-1). We show that MBP redistributes to distinct 'membrane-ruffled' regions of the plasma membrane where it co-localizes with actin and tubulin, and with the SH3-domain-containing proteins cortactin and ZO-1, when stimulated with PMA, a potent activator of the protein kinase C pathway. Moreover, using phospho-specific antibody staining, we show an increase in phosphorylated Thr98 MBP (human sequence numbering) in membrane-ruffled OLGs. Previously, Thr98 phosphorylation of MBP has been shown to affect its conformation, interactions with other proteins, and tethering of other proteins to the membrane in vitro. Here, MBP and actin were also co-localized in new focal adhesion contacts induced by IGF-1 stimulation in cells grown on laminin-2. This study supports a role for classic MBP isoforms in cytoskeletal and other protein-protein interactions during membrane and cytoskeletal remodeling in OLGs.

  11. Water and streambed-material data, Eagle Creek watershed, Indiana, August 1980, October and December 1982, and April 1983; updating of U.S. Geological Survey Open-file report 83-215

    Science.gov (United States)

    Wangsness, David J.

    1983-01-01

    Water-quality surveys within the Eagle Creek watershed were done by the U.S. Geological Survey in August 1980, October and December 1982 and April 1983 in cooperation with the city of Indianapolis, Department of Public Works. Streambed-material and water samples were collected from Finley and Eagle Creek and was analyzed for selected metals, insecticides, and acid-extractable and base-neutral-extractable compounds. Water samples also were analyzed for volatile organic compounds. The 1982-83 surveys represent different flow conditions. This report lists all the data collected and analyzed by the U.S. Geological Survey but does not interpret any of the results.

  12. Hyperspectral surface materials map of quadrangles 3668 and 3768, Baghlan (221), Taluqan (222), Imam Sahib (215), and Rustaq (216) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    Science.gov (United States)

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  13. Livelihoods and Learning: Education for All and the Marginalisation of Mobile Pastoralists. By Caroline Dyer. London: Routledge, 2014, 215 pp.; ISBN 978-0-415-58590-3 (Hardcover, 978-0-203-08390-1 (E-Book.

    Directory of Open Access Journals (Sweden)

    Alan Rogers

    2016-02-01

    Full Text Available In this book, Caroline Dyer, whose work with education in India has been known for many years through many articles, draws together her ethnographic experience of living with the Rabari of India, and reflects on what this means for Education for All goals.

  14. Hyperspectral surface materials map of quadrangles 3668 and 3768, Baghlan (221), Taluqan (222), Imam Sahib (215), and Rustaq (216) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Science.gov (United States)

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  15. From Soft Power to Economic Diplomacy? A Comparison of the Changing Rationales and Roles of the U. S. and Canadian Federal Governments in International Education. Research & Occasional Paper Series: CSHE.2.15

    Science.gov (United States)

    Trilokekar, Roopa Desai

    2015-01-01

    Through a historical and comparative analysis of international education policy development in Canada and the U.S., this paper will map the similarities and differences in the two countries. It will highlight the contributions and challenges of the government's involvement in international education (IE) in the two federal states and in…

  16. La formulación de preguntas: una alternativa metodológica que favorece la reflexión, discusión y construcción de conocimiento. (pág. 210-215

    Directory of Open Access Journals (Sweden)

    Natalia Sánchez Medina

    2010-07-01

    Full Text Available El Área de Ciencias Naturales y Educación Ambiental del Instituto Pedagógico Arturo Ramírez Montúfar (IPARM de la Universidad Nacional de Colombia – Sede Bogotá, corrobora la importancia de generar metodologías y alternativas que contribuyan al desarrollo en los estudiantes de habilidades científicas básicas que les permitan construir explicaciones a los eventos de orden biológico con una mirada propositiva y crítica, basada en el fomento de valores hacia el cuidado y respeto por su ambiente y las otras especies. En este sentido, desde del año 2007, y teniendo como antecedente inmediato las investigaciones de campo y laboratorio desarrolladas por la Línea de Investigación Faunística y Conservación de Artrópodos de la Universidad Pedagógica Nacional, se vienen desarrollando un conjunto de actividades cuyo objetivo principal es fortalecer en los estudiantes el conocimiento biológico de algunas especies de invertebrados como vínculo inmediato para la conservación y preservación de otras formas de vida.

  17. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    P. Bernot

    2005-07-13

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with {sup 231}Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or

  18. Analysis of the Yrast Bands with q-Deformed Moment of Inertia

    Institute of Scientific and Technical Information of China (English)

    FANG Xiang-Zheng; RUAN Tu-Nan

    2001-01-01

    The rigid-rotor with a q-deformed moment of inertia is introduced to describe the nuclear rotational spectra. With the representations of quantum algebra, the normal deformed and superdeformed bands are naturally differentiated by softness. The yrast normal deformed bands in rare earth and actinium regions, as well as the yrast superdeformed bands in A-190 and 150 regions are investigated. The calculated results agree with experimental data qualitatively well, and the values of the parameters are physically reasonable. This indicates that the fixed deformation, the stretching effect and the many body statistics effect are three possible dominant factors to govern nuclear rotational bands.

  19. Transition wavelengths and unresolved transition array statistics of ions with Z = 72-89

    Energy Technology Data Exchange (ETDEWEB)

    Kilbane, D, E-mail: Deirdre.Kilbane@ucd.ie [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland)

    2011-08-28

    Potential extreme ultraviolet and soft x-ray radiation sources have been identified, using the flexible atomic code (FAC), as emission peaks arising from the 4d-4f and 4p-4d transitions in Pd-like to Rb-like ions of hafnium through actinium. The effects of configuration interaction are investigated and for increasing nuclear charge, these strong emitters are seen to separate and move to shorter wavelengths. Each source is characterized using the unresolved transition array model. They are proposed to complement the currently used nitrogen and argon sources in the 'water window', and as possible successors to tin in next-generation lithography.

  20. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  1. NCBI nr-aa BLAST: CBRC-TTRU-01-1129 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1129 ref|YP_002833499.1| hypothetical protein LS215_2921 [Sulfolobus isla...ndicus L.S.2.15] gb|ACP36854.1| conserved hypothetical protein [Sulfolobus islandicus L.S.2.15] YP_002833499.1 0.031 25% ...

  2. Purification of cerium, neodymium and gadolinium for low background experiments

    Directory of Open Access Journals (Sweden)

    Boiko R.S.

    2014-01-01

    Full Text Available Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search, 136Ce (2β+ candidate with one of the highest Q2β. The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  3. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Directory of Open Access Journals (Sweden)

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  4. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics.

    Science.gov (United States)

    Singh-Joy, Subhashni D; McLain, Valerie C

    2008-01-01

    Poloxamers are polyoxyethlyene, polyoxypropylene block polymers. The impurities of commercial grade Poloxamer 188, as an example, include low-molecular-weight substances (aldehydes and both formic and acetic acids), as well as 1,4-dioxane and residual ethylene oxide and propylene oxide. Most Poloxamers function in cosmetics as surfactants, emulsifying agents, cleansing agents, and/or solubilizing agents, and are used in 141 cosmetic products at concentrations from 0.005% to 20%. Poloxamers injected intravenously in animals are rapidly excreted in the urine, with some accumulation in lung, liver, brain, and kidney tissue. In humans, the plasma concentration of Poloxamer 188 (given intravenously) reached a maximum at 1 h, then reached a steady state. Poloxamers generally were ineffective in wound healing, but were effective in reducing postsurgical adhesions in several test systems. Poloxamers can cause hypercholesterolemia and hypertriglyceridemia in animals, but overall, they are relatively nontoxic to animals, with LD(50) values reported from 5 to 34.6 g/kg. Short-term intravenous doses up to 4 g/kg of Poloxamer 108 produced no change in body weights, but did result in diffuse hepatocellular vacuolization, renal tubular dilation in kidneys, and dose-dependent vacuolization of epithelial cells in the proximal convoluted tubules. A short-term inhalation toxicity study of Poloxamer 101 at 97 mg/m(3) identified slight alveolitis after 2 weeks of exposure, which subsided in the 2-week postexposure observation period. A short-term dermal toxicity study of Poloxamer 184 in rabbits at doses up to 1000 mg/kg produced slight erythema and slight intradermal inflammatory response on histological examination, but no dose-dependent body weight, hematology, blood chemistry, or organ weight changes. A 6-month feeding study in rats and dogs of Poloxamer 188 at exposures up to 5% in the diet produced no adverse effects. Likewise, Poloxamer 331 (tested up to 0.5 g/kg day(-1)), Poloxamer 235 (tested up to 1.0 g/kg day(-1)), and Poloxamer 338 (at 0.2 or 1.0 g/kg day(-1)) produced no adverse effects in dogs. Poloxamer 338 (at 5.0 g/kg day(-1)) produced slight transient diarrhea in dogs. Poloxamer 188 at levels up to 7.5% in diet given to rats in a 2-year feeding study produced diarrhea at 5% and 7.5% levels, a small decrease in growth at the 7.5% level, but no change in survival. Doses up to 0.5 mg/kg day(-1) for 2 years using rats produced yellow discoloration of the serum, high serum alkaline phosphatase activity, and elevated serum glutamicpyruvic transaminase and glutamic-oxalacetic transaminase activities. Poloxamers are minimal ocular irritants, but are not dermal irritants or sensitizers in animals. Data on reproductive and developmental toxicity of Poloxamers were not found. An Ames test did not identify any mutagenic activity of Poloxamer 407, with or without metabolic activation. Several studies have suggested anticarcinogenic effects of Poloxamers. Poloxamers appear to increase the sensitivity to anticancer drugs of multidrug-resistant cancer cells. In clinical testing, Poloxamer 188 increased the hydration of feces when used in combination with a bulk laxative treatment. Compared to controls, one study of angioplasty patients receiving Poloxamer 188 found a reduced myocardial infarct size and a reduced incidence of reinfarction, with no evidence of toxicity, but two other studies found no effect. Poloxamer 188 given to patients suffering from sickle cell disease had decreased pain and decreased hospitilization, compared to controls. Clinical tests of dermal irritation and sensitization were uniformly negative. The Cosmetic Ingredient Review (CIR) Expert Panel stressed that the cosmetic industry should continue to use the necessary purification procedures to keep the levels below established limits for ethylene oxide, propylene oxide, and 1,4-dioxane. The Panel did note the absence of reproductive and developmental toxicity data, but, based on molecular weight and solubility, there should be little skin penetration and any penetration of the skin should be slow. Also, the available data demonstrate that Poloxamers that are introduced into the body via routes other than dermal exposure have a rapid clearance from the body, suggesting that there would be no risk of reproductive and/or developmental toxicity. Overall, the available data do not suggest any concern about carcinogenesis. Although there are gaps in knowledge about product use, the overall information available on the types of products in which these ingredients are used, and at what concentration, indicates a pattern of use. Based on these safety test data and the information that the manufacturing process can be controlled to limit unwanted impurities, the Panel concluded that these Poloxamers are safe as used.

  5. Relationship between dietary patterns and metabolic syndrome among urban populations in Ningxia, China . Journal of Zhejiang University (Agric . & Life Sci .), 2013,39(2):215-221%宁夏城市居民营养素摄入量与代谢综合征相关危险因素调查及分析

    Institute of Scientific and Technical Information of China (English)

    李宏宇; 张娜; 李琳; 陶秀娟; 杨建军; 张毓洪; 赵燚

    2013-01-01

    Summary It is well documented that the role of dietary composition in relation to the development of metabolic syndrome ( MS) remains inconclusive . Several studies on the relationship between MS and energy intake have suggested that the macronutrient composition of the diet ( proteins , fats , carbohydrates) may play an important contributing role to MS in adults . So , this study aims to investigate the possible relationship between MS and energy intake , percentage energy intake from macronutrients among urban populations in Ningxia , China . According to different economic levels from 2011 to 2012 , 2 465 subjects ( age:18‐75 years) were selected using stratified cluster random sampling in Yinchuan , Wuzhong , Zhongwei , Guyuan , and Shizuishan in Ningxia , China . Dietary intake was assessed using 24‐h food records and a validated food frequency questionnaire . Body mass , height , waist circumference , blood pressure , triglyceride ( TG ) , high‐density lipoprotein cholesterol ( HDL‐C ) , and blood glucose were measured . Logistic regression models were adjusted for age , smoking , drinking , and physical activity factors . The results showed that there were 647 MS cases in all subjects . According to the diagnosis criteria of MS , the incidence of MS was 26 .2% ( men:281 cases (25% ) ;women:366 cases ( 27 .3% ) ) , no significant difference in sex composition ( P>0 .05) . As a way of lifestyle , there was no significant difference in smoking , drinking , exercise between MS group and control group ( P>0 .05) ;significant difference was found in tertian dietary intake of protein and fat energy percentage between MS group and control group ( P0.05);MS组与对照组间吸烟、饮酒、锻炼等生活方式构成的差异无统计学意义( P>0.05);MS组与对照组间日膳食摄入蛋白质及脂肪能量百分比差异有统计学意义( P<0.05);MS组与对照组间的体质指数、腰围、收缩压、舒张压、空腹血糖、胆固醇、甘油三酯、高密度脂蛋白差异有统计学意义( P<0.05). Logistic多因素分析表明,蛋白质、脂肪及碳水化合物的能量占总摄入能量的百分比过多是城市居民代谢综合征的重要危险因素,其中高蛋白质组:相对危险程度比值比( odds ratio , OR)=1.417;高脂肪组:OR=1.647;高碳水化合物组:OR=1.810;因此,应采取膳食营养干预措施来有效预防MS .

  6. Itolizumab – a humanized anti-CD6 monoclonal antibody with better side effects profile for the treatment of psoriasis [Corrigendum

    OpenAIRE

    Menon R; David BG

    2015-01-01

    Menon R, David BG. Clinical, Cosmetic and Investigational Dermatology. 2015;8:215–22.On page 215, please note correspondence should have been listed as:   Roshni Menon, D II/17,JIPMER Campus, Dhanvanthri Nagar,Pondicherry, India 605006Tel +91 944 320 8140Email page 215, the first sentence of the Introduction was “Psoriasis is a chronic inflammatory disease of the skin characterized by exacerbations and remissions affecting 1%–3% of the wo...

  7. 48 CFR 2152.370 - Use of the matrix.

    Science.gov (United States)

    2010-10-01

    .... Text reference Title Use status FAR 52.202-1 FAR 2.201 Definitions M FAR 52.203-3 FAR 3.202 Gratuities...—Negotiation M FAR 52.215-10 FAR 15.408(b) Price Reduction for Defective Cost or Pricing Data M FAR 52.215-12 FAR 15.408(d) Subcontractor Cost or Pricing Data M FAR 52.215-15 FAR 15.408(g) Pension Adjustments...

  8. Itolizumab – a humanized anti-CD6 monoclonal antibody with better side effects profile for the treatment of psoriasis [Corrigendum

    OpenAIRE

    Menon, Roshni; David,Brinda

    2015-01-01

    Menon R, David BG. Clinical, Cosmetic and Investigational Dermatology. 2015;8:215–22.On page 215, please note correspondence should have been listed as:   Roshni Menon, D II/17,JIPMER Campus, Dhanvanthri Nagar,Pondicherry, India 605006Tel +91 944 320 8140Email page 215, the first sentence of the Introduction was “Psoriasis is a chronic inflammatory disease of the skin characterized by exacerbations and remissions affecting 1%&am...

  9. 77 FR 18907 - Schedule of Fees for Consular Services, Department of State and Overseas Embassies and Consulates

    Science.gov (United States)

    2012-03-29

    ... transferee); O (aliens with extraordinary ability); P (athletes, artists, and entertainers); Q (cultural... residency requirement... $215. (c) Waiver of immigrant visa ineligibility For fee amount, see 8 CFR...

  10. Gene : CBRC-MDOM-04-0426 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available 50 /gi=89886357 /ug=Mdm.215 /len=1443 0.014 18% MPTTTSTTTSTITSTTTTTITSTFTITSTFTITSTTTSTTTTTITITSTTTTITS...TSTTTITSTSTITSTTTTTITSTSTITSTTTITSTTSTTITSTTTTITSTTTTTSTTTTTTITSTSTITSTTTTTITSTSTTTTTITSTTTTTITSTSITSTTTTTTITS...TSTITSTTTTTTTTSTTITSTTTITSTTTTTITSTTSSTSTTTTTTSTTITSTTTTSTTTITSTTITSTITTTSTTITSTTTITSTTTTTITSTTTITSTTTTTITS...TTSSTSTTTTTSTTITSTTTTSTTTITSTTTTTITSTTSSTSTTTTTSTTITSTPTTSTTTTSTTITSTTTTSTTITS...TTTITSTTTTTITSASTTTTTTITSTSTTITSTTTTTITSTSTITSTTTTTITSTSTITSITTSTITSTSTITSTTTTTSTTITSTTTITSTTTTTTTSTTTTSTTTSATITS

  11. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  12. Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion

    Science.gov (United States)

    Ferrer, R.; Barzakh, A.; Bastin, B.; Beerwerth, R.; Block, M.; Creemers, P.; Grawe, H.; de Groote, R.; Delahaye, P.; Fléchard, X.; Franchoo, S.; Fritzsche, S.; Gaffney, L. P.; Ghys, L.; Gins, W.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Loiselet, M.; Lutton, F.; Moore, I. D.; Martínez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Raeder, S.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Thomas, J-C; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2017-01-01

    Resonant laser ionization and spectroscopy are widely used techniques at radioactive ion beam facilities to produce pure beams of exotic nuclei and measure the shape, size, spin and electromagnetic multipole moments of these nuclei. However, in such measurements it is difficult to combine a high efficiency with a high spectral resolution. Here we demonstrate the on-line application of atomic laser ionization spectroscopy in a supersonic gas jet, a technique suited for high-precision studies of the ground- and isomeric-state properties of nuclei located at the extremes of stability. The technique is characterized in a measurement on actinium isotopes around the N=126 neutron shell closure. A significant improvement in the spectral resolution by more than one order of magnitude is achieved in these experiments without loss in efficiency. PMID:28224987

  13. Temporal Variations in Surface Concentrations of Terrestrial Lead 210 and Uranium 235 Radionucleides

    Science.gov (United States)

    Yoshimori, M.

    We have started to measure the surface concentrations of terrestrial radionucleides of lead 210 and uranium 235 in Tokyo (N35, E139) in 2002. Lead 210 which is a daughter nucleus of Rn-222 (uranium series) emits 46 keV gamma-ray with a half-life of 22.4 years, while uranium 235 (actinium series) emits a gamma-ray at 186 keV with a half-life of 0.7 billion years. The present measurement of the surface concentration of lead 210 exhibits two peaks in spring and fall, similar to the beryllium 7 seasonal variations, while the uranium 235 concentration does not vary with time within statistical errors. These two terrestrial radionucleides exhibit different temporal variations on the surface. We discuss possible explanations for the differences in the temporal variations from a point of view of differences in their altitude distribution.

  14. 两种稀土产品中放射性核素分析研究%ANALYSIS OF RADIONUCLIDES IN TWO RARE EARTH PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    周程; 孙恋君

    2009-01-01

    利用高纯锗γ谱仪对两个稀土产品氯化镧和氯化钇的样品进行能谱分析,研究经湿法冶炼工艺后的稀土产品中放射性核素的活度变化.结果表明,样品中存在天然放射性钍系和锕-铀系的核素,以及天然放射性核素~(138)La和~(176)Lu,但两个样品中所含的放射性核素不相同.氯化镧产品中锕-铀系和钍系核素放射性未达平衡,其主要子体~(224)Ra和~(227)Th的含量随时间发生明显变化,约60天达到平衡;而氯化钇产品没有这种现象.%This paper describes a study on raidoactivity change of rare-earth products after hydrometallurgy technology,using HPGe gamma spectrometer to analyze two rare earth products (LaCl_3 and YCl_3).The results show that in the two samples exist natural radionuclides of thorium series and actinium-uranium series as well as other natural radionuclides 138 La and 176 Lu.In the sample of lanthanum chloride the radioactivity of actinium-uranium series and thorium series has not reached balance,the contents of their main progenies ~(226)Ra and ~(227)Th obviously changes with the time,reaching balance 60 days later,while YCl_3 keeps stability.

  15. Evaluation of total effective dose due to certain environmentally placed naturally occurring radioactive materials using a procedural adaptation of RESRAD code.

    Science.gov (United States)

    Beauvais, Z S; Thompson, K H; Kearfott, K J

    2009-07-01

    Due to a recent upward trend in the price of uranium and subsequent increased interest in uranium mining, accurate modeling of baseline dose from environmental sources of radioactivity is of increasing interest. Residual radioactivity model and code (RESRAD) is a program used to model environmental movement and calculate the dose due to the inhalation, ingestion, and exposure to radioactive materials following a placement. This paper presents a novel use of RESRAD for the calculation of dose from non-enhanced, or ancient, naturally occurring radioactive material (NORM). In order to use RESRAD to calculate the total effective dose (TED) due to ancient NORM, a procedural adaptation was developed to negate the effects of time progressive distribution of radioactive materials. A dose due to United States' average concentrations of uranium, actinium, and thorium series radionuclides was then calculated. For adults exposed in a residential setting and assumed to eat significant amounts of food grown in NORM concentrated areas, the annual dose due to national average NORM concentrations was 0.935 mSv y(-1). A set of environmental dose factors were calculated for simple estimation of dose from uranium, thorium, and actinium series radionuclides for various age groups and exposure scenarios as a function of elemental uranium and thorium activity concentrations in groundwater and soil. The values of these factors for uranium were lowest for an adult exposed in an industrial setting: 0.00476 microSv kg Bq(-1) y(-1) for soil and 0.00596 microSv m(3) Bq(-1) y(-1) for water (assuming a 1:1 234U:238U activity ratio in water). The uranium factors were highest for infants exposed in a residential setting and assumed to ingest food grown onsite: 34.8 microSv kg Bq(-1) y(-1) in soil and 13.0 microSv m(3) Bq(-1) y(-1) in water.

  16. Origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department); Origine des elements de la famille de l'uranium-235 observes dans la riviere Ellez a proximite du reacteur nucleaire experimental EL4 en cours de demantelement (Mont d'Arree - departement du Finistere). Resultats et premiers constats annee 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 ({sup 227}Ac), non born by its ascendents which are {sup 235}U and {sup 231}Pa is observed. This phenomenon is characterized by mass activities superior to these ones of {sup 235}U and able to reach these ones of {sup 238}U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil ({sup 210}Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  17. 48 CFR 2152.070 - Applicable clauses.

    Science.gov (United States)

    2010-10-01

    ... Asset Reversions 52.215-16Facilities Capital Cost of Money 52.215-17Waiver of Facilities Capital Cost of...-21Prohibition of Segregated Facilities 52.222-22Previous Contracts and Compliance Reports 52.222-25Affirmative...-63Preference for U.S.-Flag Air Carriers 52.249-2Termination for Convenience of the Government (Fixed Price)...

  18. EST Table: CK516660 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK516660 rswjb0_004566.y1 11/12/09 n.h 10/09/29 71 %/215 aa ref|XP_968436.2| PREDICTED: similar to best... %/176 aa gnl|Amel|GB16861-PA 10/09/10 71 %/215 aa gi|189235903|ref|XP_968436.2| PREDICTED: similar to bes

  19. 78 FR 65214 - Defense Federal Acquisition Regulation Supplement: Only One Offer-Further Implementation (DFARS...

    Science.gov (United States)

    2013-10-31

    ... solicitations for commercial items; however, the prescription at 215.371-6 inadvertently omitted restating... commercial items; however, the prescriptions at 215.408(3) inadvertently omitted restating applicability of... from the Canadian Commercial Corporation. DATES: Effective October 31, 2013. FOR FURTHER...

  20. 76 FR 30703 - Delegation of Authority to the Commonwealth of Pennsylvania To Implement and Enforce Additional...

    Science.gov (United States)

    2011-05-26

    ....gov/reg3artd/airregulations/delegate/padelegation.htm . FOR FURTHER INFORMATION CONTACT: Ray Chalmers, (215) 814-2061, or by e- mail at chalmers.ray@epa.gov . SUPPLEMENTARY INFORMATION: Pennsylvania..., please contact me at 814-2706 or Ray Chalmers of my staff at 215-814-2061. Sincerely, Diana...

  1. Drug: D08624 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08624 Drug Tramazoline (INN); Muconasal (TN) C13H17N3 215.1422 215.2942 D08624.gif...970(146+147+148) Salivary secretion Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] R RESPIRATORY SYSTEM R01 NASA...L PREPARATIONS R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE R01AA

  2. Atmospheric Correction and Vicarious Calibration of Oceansat-1 Ocean Color Monitor (OCM) Data in Coastal Case 2 Waters

    Science.gov (United States)

    2012-06-08

    Fundamentals and Prospective Applications; Toselli , F., Bodechtel, J., Eds.; Kluwer: London, UK, 1992; pp. 215–257. 31. Bailey, S.; Franz, B... Toselli , F., Bodechtel, J., Eds.; Kluwer: London, UK, 1992; pp. 215–257. 31. Bailey, S.; Franz, B. Personal Communication. 21 October 2009. 32

  3. NCBI nr-aa BLAST: CBRC-MEUG-01-1725 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MEUG-01-1725 ref|YP_002831676.1| major facilitator superfamily MFS_1 [Sulfolobus isla...ndicus L.S.2.15] gb|ACP35031.1| major facilitator superfamily MFS_1 [Sulfolobus islandicus L.S.2.15] YP_002831676.1 0.78 28% ...

  4. EST Table: FS904669 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS904669 E_FL_fufe_02L06_F_0 10/09/28 39 %/215 aa ref|XP_967337.1| PREDICTED: similar to Serge... %/215 aa gi|91083383|ref|XP_967337.1| PREDICTED: similar to Sergef protein [Tribolium castaneum] FS910504 fufe ...

  5. Drug: D04905 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available HCl 215.1441 215.7628 D04905.gif Treatment of Alzheimer's disease [DS:H00056] Therapeutic category: 1190 ATC...3+2904+2905+2906) Glutamatergic synapse hsa05010(2902+2903+2904+2905+2906) Alzheimer's disease Transporter: ...SLC22A2 [HSA:6582] map07056 Agents for Alzheimer-type dementia map07235 N-Metyl-D

  6. Drug: D06125 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06125 Drug Tiamenidine (USAN/INN); Symcor base TTS (TN) C8H10ClN3S 215.0284 215.7031 D06125.gif Antihyperte...nsive CAS: 31428-61-2 PubChem: 47207783 LigandBox: D06125 NIKKAJI: J20.515J ATOM 13

  7. Dollar Summary of Prime Contract Awards by State, Place, and Contractor, FY84, Part 4, (Allenville, Missouri-Wyoming, Pennsylvania).

    Science.gov (United States)

    1984-01-01

    CRESCENT GAGE & TOOL SALES INC 28 28 CROSSROADS TL & MFG INC 368 366 CROWN SERVICES INC 49 49 D M L MACHINE CORPORATION 215- 215- DARWIN INDUSTRIES 30...INC 417 417 CARTWRIGHT BREISCH ENGINEERING CO 179 179 QIAID, DARYL 59 59 T & S SERVICES CO 32 32 TOTAL - CARTWRIGHT 270 270 MPC911 PRIME CONTRACT AWARDS

  8. NCBI nr-aa BLAST: CBRC-TTRU-01-0337 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0337 ref|XP_719437.1| CTA215 antisense protein [Candida albicans SC531...4] gb|EAL00553.1| CTA215 antisense protein [Candida albicans SC5314] XP_719437.1 0.024 30% ...

  9. NCBI nr-aa BLAST: CBRC-TTRU-01-0375 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0375 ref|XP_719437.1| CTA215 antisense protein [Candida albicans SC531...4] gb|EAL00553.1| CTA215 antisense protein [Candida albicans SC5314] XP_719437.1 0.058 31% ...

  10. Efficient autophosphorylation and phosphorylation of the beta-subunit by casein kinase-2 require the integrity of an acidic cluster 50 residues downstream from the phosphoacceptor site

    DEFF Research Database (Denmark)

    Boldyreff, B; Meggio, F; Pinna, L A;

    1994-01-01

    -64 are also involved in the process of autophosphorylation, possibly by means of a loop formation. The results obtained with the COOH-terminal-deleted mutants support the view that reconstitution of a functional holoenzyme must occur to allow efficient autophosphorylation. Polylysine prevents...... mutants reconstituting a tetrameric holoenzyme. Only with the three largest COOH-terminal deletion mutants beta delta 150-215, beta delta 171-215, and beta delta 181-215 is no significant alpha-subunit autophosphorylation observed. The phosphorylation of the beta-subunit mutants added in large molar...... excess to CK-2 holoenzyme (either native or recombinant) is also severely impaired by Ala for Glu/Asp substitutions at position 5,6 and in the 55-64 region and by the deletion of the COOH-terminal segments 150-215 and 171-215. Such a phosphorylation is inhibited by polylysine, with the exception...

  11. Arginine synthesis from enteral glutamine in healthy adults in the fed state.

    Science.gov (United States)

    Tomlinson, Chris; Rafii, Mahroukh; Ball, Ronald O; Pencharz, Paul

    2011-08-01

    Recent studies have documented transfer of labeled nitrogen from [2-(15)N]glutamine to citrulline and arginine in fasting human adults. Conversely, in neonates and piglets we have shown no synthesis of arginine from [2-(15)N]glutamate, and others have shown in mice that glutamine is a nitrogen, but not a carbon donor, for arginine synthesis. Therefore, we performed a multitracer study to determine whether glutamine is a nitrogen and/or carbon donor for arginine in healthy adult men. Two glutamine tracers, 2-(15)N and 1-(13)C, were given enterally to five healthy men fed a standardized milkshake diet. There was no difference in plasma enrichments between the two glutamine tracers. 1-(13)C isotopomers of citrulline and arginine were synthesized from [1-(13)C]glutamine. Three isotopomers each of citrulline and arginine were synthesized from the [2-(15)N]glutamine tracer: 2-(15)N, 5-(15)N, and 2,5-(15)N(2). Significantly greater enrichment was found of both [5-(15)N]arginine (0.75%) and citrulline (3.98%) compared with [2-(15)N]arginine (0.44%) and [2-(15)N]citrulline (2.62%), indicating the amino NH(2) from glutamine is mostly transferred to arginine and citrulline by transamination. Similarly, the enrichment of the 1-(13)C isotopomers was significantly less than the 2-(15)N isotopomers, suggesting rapid formation of α-ketoglutarate and recycling of the nitrogen label. Our results show that the carbon for 50% of newly synthesized arginine comes from dietary glutamine but that glutamine acts primarily as a nitrogen donor for arginine synthesis. Hence, studies using [2-(15)N]glutamine will overestimate arginine synthesis rates.

  12. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  13. Dicty_cDB: Contig-U04374-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available bjct: 100 tccctttagctaatcaagtaatattcacaaattctaataataaatcagtaataatatcca 159 Query: 160 atcaagaaactcattttaaacaagaggtattagtttcan...|||||||||| Sbjct: 160 atcaagaaactcattttaaacaagaggtattagtttcancaattntagnggatg 213 Score = 119 bits (60), Expe...) Strand = Plus / Plus Query: 187 tattagtttcancaattntagnggatgat 215 ||||||||||| ||||| ||| ||||||| Sbjct: 1 t

  14. 75 FR 25238 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2010-05-07

    ..., Brunswick, ME, Comment Period Ends: 06/28/2010, Contact: Thomas H. Stephan, 215-897-4916. EIS No. 20100163.... EIS No. 20100164, Draft EIS, BLM, 00, Southern California Edison's Eldorado-Ivanpah Transmission...

  15. Teachers’ individual action theories about competence-based education: the value of the cognitive apprenticeship model

    OpenAIRE

    2009-01-01

    Seezink, A., Poell, R. F., & Kirschner, P. A. (2009). Teachers' individual action theories about competence-based education: The value of the cognitive apprenticeship model. Journal of Vocational Education & Training, 61, 203-215.

  16. Neuroprotective role of 15-deoxy-△12,14 -prostaglandin J2 in ischelic stroke%15-脱氧-△12,14-前列腺素J2在脑缺血中的神经保护作用

    Institute of Scientific and Technical Information of China (English)

    李文惠; 刘喆

    2011-01-01

    15-deoxy-△12,14-prostaglandin J2(15d-PGJ2) is one of the natural ligands of the peroxisome proliferator-activated receptor γ.It plays an important protective role during cerebral ischemia.This article reviews the recent progress in research on the neuroprotective mechanism of 15d-PGJ2.%15-脱氧-△12,14-前列腺素J2(15-deoxy-△12,14-prostaglandin J2,15d-PGJ2)是过氧化物酶体增殖物激活受体γ的天然配体之一,在脑缺血中发挥重要的保护作用.文章对15d-PGJ2神经保护机制的研究进展进行了综述.

  17. Thermophysical and Electronic Properties Information Analysis Center (TEPIAC): A Continuing Systematic Program on Data Tables of Thermophysical and Electronic Properties of Materials.

    Science.gov (United States)

    1980-03-01

    215 REFERENCES ---------------------------------------------------------------------------- 217 80 CHAPTER 8 - SEISMIC WAVE VLILOCITY 8.0...Research Lab. U.S. Army Missile Command West Lafayette, IN Redstone Arsenal Huntsville, AL Westinghouse Hanford Co. Richland, WA U.S. Army Prod

  18. 78 FR 44575 - Office of the Director, National Institutes of Health; Notice of Meeting

    Science.gov (United States)

    2013-07-24

    ... sign language interpretation or other reasonable accommodations, should notify the Contact Person... 15, 2013, 1:45 p.m. to 2:15 p.m. Agenda: Review of Grant Applications. Contact Person: Robin...

  19. Go-go, 40 miljonit krooni! / Kadri Paas, Laura Birkin

    Index Scriptorium Estoniae

    Paas, Kadri, 1982-

    2007-01-01

    Majandus- ja kommunikatsiooniminister Juhan Parts tegi valitsusele ettepaneku anda maabussiliinide toetuseks veel 20 miljonit ja Edelaraudteele 21,5 miljonit krooni, Eesti Reformierakond ootab ministri selgitusi. Vt. samas: GoBus: mei ei saa bussisõidule peale maksta

  20. 78 FR 63184 - Delegation of Authority to the Commonwealth of Virginia To Implement and Enforce Additional or...

    Science.gov (United States)

    2013-10-23

    ....gov/reg3artd/airregulations/delegate/vadelegation.htm . FOR FURTHER INFORMATION CONTACT: Ray Chalmers, (215) 814-2061, or by email at chalmers.ray@epa.gov . SUPPLEMENTARY INFORMATION: On February 14,...

  1. 76 FR 69268 - Delegation of Authority to the State of West Virginia To Implement and Enforce Additional or...

    Science.gov (United States)

    2011-11-08

    .../reg3artd/airregulations/delegate/wvdelegation.htm . FOR FURTHER INFORMATION CONTACT: Ray Chalmers, (215) 814-2061, or by email at chalmers.ray@epa.gov . SUPPLEMENTARY INFORMATION: West Virginia notified...

  2. 77 FR 37039 - Delegation of Authority to the State of Maryland To Implement and Enforce Additional or Revised...

    Science.gov (United States)

    2012-06-20

    .../airregulations/delegate/mddelegation.htm . FOR FURTHER INFORMATION CONTACT: Ray Chalmers, (215) 814-2061, or by email at chalmers.ray@epa.gov . SUPPLEMENTARY INFORMATION: On March 7, 2012, Maryland notified EPA...

  3. 77 FR 47838 - Delegation of Authority to the State of West Virginia To Implement and Enforce Additional or...

    Science.gov (United States)

    2012-08-10

    .../reg3artd/airregulations/delegate/wvdelegation.htm . FOR FURTHER INFORMATION CONTACT: Ray Chalmers, (215) 814-2061, or by email at chalmers.ray@epa.gov . SUPPLEMENTARY INFORMATION: On June 6, 2012,...

  4. 76 FR 28433 - Delegation of Authority to the State of West Virginia To Implement and Enforce Additional or...

    Science.gov (United States)

    2011-05-17

    .../airregulations/delegate/wvdelegation.htm . FOR FURTHER INFORMATION CONTACT: Ray Chalmers, (215) 814-2061, or by e- mail at chalmers.ray@epa.gov . SUPPLEMENTARY INFORMATION: West Virginia notified EPA that West...

  5. 76 FR 30703 - Delegation of Authority to the Commonwealth of Virginia To Implement and Enforce Additional or...

    Science.gov (United States)

    2011-05-26

    ....gov/reg3artd/airregulations/delegate/vadelegation.htm . FOR FURTHER INFORMATION CONTACT: Ray Chalmers, (215) 814-2061, or by e- mail at chalmers.ray@epa.gov . SUPPLEMENTARY INFORMATION: Virginia...

  6. 77 FR 28875 - Delegation of Authority to the Commonwealth of Virginia To Implement and Enforce Additional or...

    Science.gov (United States)

    2012-05-16

    ....gov/reg3artd/airregulations/delegate/vadelegation.htm . FOR FURTHER INFORMATION CONTACT: Ray Chalmers, (215) 814-2061, or by email at chalmers.ray@epa.gov . SUPPLEMENTARY INFORMATION: On February 16,...

  7. 78 FR 43210 - Bracco Diagnostics et al.; Withdrawal of Approval of 52 New Drug Applications and 77 Abbreviated...

    Science.gov (United States)

    2013-07-19

    ..., Nesher 15 mg/5 mL. Pharmaceuticals (USA) LLC, 13910 Saint Charles Rock Rd., Bridgton, MO 63044. ANDA.... MN 55427. NDA 050261 Declomycin CorePharma, LLC, 215 (demeclocycline HCl) Wood Ave., Tablets, 75...

  8. Epidemiological Investigation of Lifestyle Associated Modifiable Risk Factors among Medical Students

    Directory of Open Access Journals (Sweden)

    Anurag Srivastava

    2013-06-01

    Conclusion: The study shows a high prevalence of NCD related risk factors in medical students. Primary prevention may be one way to lower the risk burden of NCDs. [Natl J Med Res 2013; 3(3.000: 210-215

  9. USA terrorismivastane seadus ja jälitustegevuse erivolitused / Piibe Jõgi

    Index Scriptorium Estoniae

    Jõgi, Piibe, 1969-

    2007-01-01

    24. okt. 2001 Ameerika Ühendriikides vastu võetud terrorismivastase seaduse (nn USA Patriot Act) paragrahvist 215, mis käsitleb andmete salajast kogumist ja paragrahvist 213 salajaste läbiotsimisite kohta

  10. 76 FR 18188 - Procurement List; Proposed Additions and Deletions

    Science.gov (United States)

    2011-04-01

    ... following products and service are proposed for addition to Procurement List for production by the nonprofit agencies listed: Products Towel, Highly Absorbent, Synthetic ``Shammy'' NSN: 7920-01-215-6568--15x15....

  11. 75 FR 52957 - Supplemental Funding Under the Food and Drug Administration's Food Emergency Response Laboratory...

    Science.gov (United States)

    2010-08-30

    ... HUMAN SERVICES Food and Drug Administration Supplemental Funding Under the Food and Drug Administration's Food Emergency Response Laboratory Network Microbiological Cooperative Agreement Program (U18) PAR-09-215; Request for Supplemental Applications AGENCY: Food and Drug Administration, HHS....

  12. Data of evolutionary structure change: 1BIJA-1YGDD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1BIJA-1YGDD 1BIJ 1YGD A D -VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPT...SKYR MHLTPEEKSAVTALWGKVN--VDEVGGEALGRLLVVYPETQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGT---F... 215 VAL CA 288 ASP CA 212 1YGD D 1YGDD AFSDGLAHLDNLK 1 1YGD

  13. Nearshore marine fish assemblages in southern California

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish benthic trawls were completed by the Southern California Coastal Water Research Project (SCCWRP). Data from 425 fisheries independent trawls ranging from 2-215...

  14. Gclust Server: 95413 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 95413 HSA_21040245 Cluster Sequences Related Sequences(215) 445 NP_631902.1 amyotrophic...ive annotation NP_631902.1 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 ; no a

  15. 75 FR 16082 - Smaller Learning Communities Program

    Science.gov (United States)

    2010-03-31

    ... outcome data. (2) Collaborative professional development and coaching, including classroom observation. (3... Smaller Learning Communities Program Catalog of Federal Domestic Assistance (CFDA) Number: 84.215L. AGENCY... the Smaller Learning Communities (SLC) program. The Assistant Secretary will use these...

  16. Sõna ei saanud teoks / Vootele Hansen

    Index Scriptorium Estoniae

    Hansen, Vootele, 1962-

    2002-01-01

    Ilmunud ka: Sakala, Pärnu Postimees 13. november lk. 2,15, Nädaline 19. november lk. 4. Rahvaliidu saadikud ei osalenud riigieelarvekava hääletusel. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik

  17. 76 FR 81793 - Net Worth Standard for Accredited Investors

    Science.gov (United States)

    2011-12-29

    ...) and have a reasonable expectation of reaching the same income level in the current year. Id. Rule 215...\\ See Ghent, Andra C. and Kudlyak, Marianna, ``Recourse and Residential Mortgage Default: Theory...

  18. Distribution and antibiotic resistance of the microorganisms isolated from blood samples in newborns%新生儿血液标本分离菌株的种类及耐药性分析

    Institute of Scientific and Technical Information of China (English)

    石光顺; 沈继录

    2012-01-01

    目的 了解新生儿血培养细菌分布及其耐药性情况.方法 对2006年1月1日-2010年12月31日在安徽医科大学第一附属医院住院的新生儿血培养结果进行回顾性分析.应用WHONET 5.4软件进行统计分析.结果 5年共收集新生儿血液标本分离菌215株,其中革兰阳性球菌占66.1%(142/215),革兰阴性菌占24.2%(52/215),真菌占9.8%(21/215).最常见的分离菌依次为凝固酶阴性葡萄球菌42.3%(91/215)、肺炎克雷伯菌16.7%(36/215)、肠球菌16.3%(35/215)和白念珠菌9.8%(18/215).甲氧西林耐药的金葡菌(MRSA)和凝固酶阴性葡萄球菌(MRCNS)分别占各自菌种的18.2%(2/11)和68.1%(62/91).未发现万古霉素、替考拉宁和利奈唑胺耐药菌株.肺炎克雷伯菌产ESBLs株占94.4%(34/36),6株大肠埃希菌产ESBLs(6/7),未发现碳青霉烯类抗生素耐药株.结论 新生儿血液标本主要分离菌以凝固酶阴性葡萄球菌最为常见.细菌多重耐药现象严重.%Objective To investigate the distribution and antimicrobial resistance of microorganisms isolated from blood specimens in newborns. Methods The results of blood culture in the newborns treated in our hospital from January 2006 to December 2010 were reviewed retrospectively. The data were analyzed with WHONET 5. 4 software. Results A total of 215 bacterial strains were collected in the last 5 years. Gram-positive cocci, gram-negative bacilli and fungus account for 66. 1 % (142/215), 24. 2% (52/215) and 9. 8% (21/215) , respectively. The isolates were mainly coagulase-negative Staphylococcus (42. 3%, 91/ 215), K. Pneumoniae (16.7%, 36/215), Enterococcus (16.3%, 35/215) and C. Albicans (9.8%, 18/215). The prevalence of MRSA and MRCNS were 18. 2% and 68. 1% , respectively. No staphylococcal or enterococcal strain was resistant to vancomycin, teicoplanin or linezolid. ESBLs-producing strains were identified in 94. 4% (34/36) of K. Pneumoniae and 6 strains of E. Coli (6/7). No strain of K

  19. 78 FR 22255 - Environmental Management Site-Specific Advisory Board, Northern New Mexico

    Science.gov (United States)

    2013-04-15

    ..., 2013 3. 2:05 p.m. Old Business Terminology usage ``Contaminant'' 4. 2:15 p.m. New Business... conduct the meeting in a fashion that will facilitate the orderly conduct of business. Individuals...

  20. BIOMASS, SPECIES IDENTIFICATION, TAXONOMIC CODE, SPECIES IDENTIFICATION - LIFE STAGE and species abundance tows data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-10 to 2004-10-07 (NODC Accession 0113896)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113896 includes tows and biological data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211, HX215, HX217,...

  1. Drug: D09967 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ide bridge: 23-89; 135-195; H230-L215, Dimer) Peptide Uveitis, rheumatoid arthritis, psoriasis ATC code: L04...teraction hsa05323(3605) Rheumatoid arthritis map07050 Antirheumatics - DMARDs and biological agents Anatomi

  2. 77 FR 45869 - Endangered and Threatened Wildlife and Plants; Listing the British Columbia Distinct Population...

    Science.gov (United States)

    2012-08-01

    ... determination based on the existing 1979 TLMP (Southwest Center for Biological Diversity v. Babbitt, 939 F. Supp... (Southwest Center for Biological Diversity v. Babbitt, 215 F. 3d 58 (D.C.C. 2000)). On July 29, 2002,...

  3. Report on the FY 1986 Activities of the Defense Science Study Group. Volume 1.

    Science.gov (United States)

    1987-05-01

    Agency Daniel Alpert Director, Center for Advanced Studies, 0 University of Illinois Richard B. Bernstein Professor of Chemistry, University of...Cafeteria System Challenges in Space Access Systems 1:30- 2:15 p.m. Aerospace Plane Concepts and Larry Hunt, Technologies NASA Langley ,,A 2:15- 3:00 p.m...on November 8, 1986 0-0 Dr. Daniel Alpert Director, Center for Advanced Study -, University of Illinois Professor Richard Bernstein University of

  4. 21st Century Civil-Military Relations: Disharmony and Dysfunction

    Science.gov (United States)

    2013-03-01

    Colleges and Schools , 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an institutional accrediting...States Association of Colleges and Schools , 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...tension between our liberal civilian society and the military, typified by the debate on women in combat and open homosexuals in the military; and

  5. Environmental Assessment Addressing the Defense Language Institute English Language Center (DLIELC), and the Inter-American Air Forces Academy (IAAFA) Area Development Plan at Lackland Air Force Base, Texas

    Science.gov (United States)

    2012-01-01

    Shelter 2,805 222 7539 Troop Shelter 2,805 222 7620 Latrine 448 35 9110 BMT Dormitory 215,824 17,050 9210 BMT Dormitory 215,824 17,050 9310 BMT...as SQGs; and nine facilities within the Lackland Leaseback Area are classified as CESQGs. There are currently 222 satellite accumulation points...repairs and renovations occur, the ballasts are removed and disposed of as hazardous waste (LAFB 2002b). Radon . Lackland AFB is in Federal USEPA

  6. National Strategy for the Southwest Border: Having the Desired Effect?

    Science.gov (United States)

    2011-03-18

    Education of the Middle State Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on...and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an institutional accrediting agency...this brutality occurred when “the Zetas stuffed four Nuevo Laredo police officers inside barrels of diesel fuel and burned them to death.”22 As

  7. Dit cyklende selv

    DEFF Research Database (Denmark)

    Larsen, Steen Nepper

    2013-01-01

    Skriver d.21.5. på opfordring af red. Esben Schiørring en kronik til Berlingske Tidende. Bliver bragt i fb.m. dækningen af årets Tour de France......Skriver d.21.5. på opfordring af red. Esben Schiørring en kronik til Berlingske Tidende. Bliver bragt i fb.m. dækningen af årets Tour de France...

  8. Extending the Time to Proficiency Model for Simultaneous Application to Multiple Jobs

    Science.gov (United States)

    1990-07-01

    University College Station, Texas 77843 E S Dwight C. Hageman Metrica , Incorporated 0 8301 Broadway, Suite 215 U San Antonio, Texas 78209 R July 1990 C...Brice M. Stone 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION Metrica , Incorporated REPORT NUMBER 8301 Broadway, Suite...I A /_ *. iilty Codes Dwight C. Hageman . ./or Metrica , Incorporated 8301 Broadway, Suite 215 A I! San Antonio, Texas 78209 Reviewed by Malcolm J

  9. Direct numerical simulation of Taylor–Couette flow with grooved walls: torque scaling and flow structure

    NARCIS (Netherlands)

    Zhu, X.; Ostilla-Monico, Rodolfo; Verzicco, R.; Lohse, D.

    2016-01-01

    We present direct numerical simulations of Taylor–Couette flow with grooved walls at a fixed radius ratio ${\\it\\eta}=r_{i}/r_{o}=0.714$η=ri/ro=0.714 with inner cylinder Reynolds number up to $Re_{i}=3.76\\times 10^{4}$Rei=3.76×104, corresponding to Taylor number up to $Ta=2.15\\times 10^{9}$Ta=2.15×10

  10. FCS: Why the Army Is Challenged to Show Its Value

    Science.gov (United States)

    2008-03-28

    Middle State Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an institutional accrediting agency recognized... olfactory sensors.21 As if more complexity is needed, when evaluating situational awareness within military applications, personal traits such as

  11. Evaluating Army Aviation’s Force Structure to Support an Operational Reserve Force

    Science.gov (United States)

    2011-03-21

    Higher Education of the Middle State Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on...the Commission on Higher Education of the Middle States Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662...and Reserves,” May 4, 2006, http://www.heritage.org/ Reseach /Testimony/Shaping-the-21st- Century-Role-of-the-National-Guard-and-Reserves (assessed

  12. Fighting the Hydra: America’s Southern Border and National Security

    Science.gov (United States)

    2011-03-23

    Higher Education of the Middle State Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission... Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an institutional accrediting agency recognized by the...Northern Mexico have had limited success. The city of Ciudad Juarez, which borders El Paso TX, earned the dubious distinction as the most violent city

  13. Contracting: Creating Gaps in Expeditionary Warfighting Capability

    Science.gov (United States)

    2011-03-01

    Education of the Middle State Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher...Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...drug cartel related violence is estimated to be approximately 28,000.3 Violence against Americans in border towns like Tijuana and Ciudad Juarez

  14. Narcotics-Fueled Violence in Mexico: Crisis for the United States?

    Science.gov (United States)

    2011-03-24

    Education of the Middle State Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on...Education of the Middle States Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on...in Mexico, especially in border cities such as Ciudad de Juarez, has climbed dramatically in the last five years.2 The violence has yet to spill over

  15. Merida Initiative: The Answer for Mexico?

    Science.gov (United States)

    2011-03-15

    Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an institutional accrediting agency...Targets and tactics: Terrorist-style attacks have occurred in Mexico’s drug war (a remote controlled car bomb in Ciudad Juarez, a grenade attack on

  16. Is the Army Communicating Effectively in Today’s Information Environment

    Science.gov (United States)

    2013-03-01

    Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...Higher Education of the Middle States Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission...such as Apple TV and digital entertainment distribution companies including Netflix , Hulu and Google+, consumers can design an entire entertainment

  17. Statistical Constraints on Station Clock Parameters in the NRCAN PPP Estimation Process

    Science.gov (United States)

    2008-12-01

    code measurements,” Metrologia , 42, 215-232. [2] R. Dach, U. Hugentobler, T. Schildknecht, L.-G. Bernier, and G. Dudle, 2002, “Precise Continuous...1490. [3] J. Ray and K. Senior, 2003, “IGS/BIPM pilot project: GPS carrier phase for time/frequency transfer and timescale formation,” Metrologia ...Geodetic techniques for time and frequency comparisons using GPS phase and code measurements,” Metrologia , 42, 215-232. 457 40th Annual Precise Time

  18. U.S. Government Interagency Reform Needed in Support of National Security

    Science.gov (United States)

    2013-03-01

    Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...Commission on Higher Education of the Middle States Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606...16Henry J. Hyde and Richard G. Lugar , Legislation on Foreign Relations Through 2002 (Washington, DC: U.S. Government Printing Office, July 2003), 19

  19. Regionalization: The Cure for an Ailing Intelligence Career Field

    Science.gov (United States)

    2013-03-01

    10 To borrow a marketing analogy, brand to brand ( B2B ) marketing is critical when operating in a resource constrained environment. “If left...Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an institutional...Middle States Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education

  20. Modification of the activity of an a-amylase from Bacillus licheniformis by several surfactants

    OpenAIRE

    2006-01-01

    The influence of different commercial surfactants on the enzymatic activity of a commercial ??-amylase from Bacillus licheniformis (Termamyl 300 L) has been studied. As non-ionic surfactants, alkyl polyglycosides (Glucopon?? 215, Glucopon?? 600 and Glucopon?? 650) were studied, as were fatty alcohol ethoxylates (Findet 1214N/23 and Findet 10/15), and nonyl phenol ethoxylate (Findet 9Q/21.5NF). Also, an anionic surfactant, linear alkyl benzene sulfonate (LAS) was assayed. In general, none of t...

  1. Rutherford's curriculum vitae, 1894-1907.

    Science.gov (United States)

    Cohen, M

    1995-06-01

    A single page, handwritten document was discovered when the Macdonald Physics building of McGill University in Montreal was gutted in 1978. This proved to be the draft of Ernest Rutherford's curriculum vitae (C.V.) covering the years 1894-1907, probably written in the autumn of 1906 when Rutherford was preparing to leave McGill. The C.V. contains 21 headings in chronological order, referring to research and other activities of Rutherford and his coauthors (especially Soddy and Barnes), plus a further set of headings relating to the associated investigations of Rutherford's team, including Eve and Hahn. A transcript of the document is provided, although in several places, Rutherford's handwriting is difficult to interpret, and the significance of his abbreviations is not always clear. Each of the items in the C.V. is discussed briefly in this review, in the light both of Rutherford's personal career and of the contribution of his team to the development and understanding of radioactivity. This contribution included the cause and nature of radioactivity (with Soddy), energy aspects of radioactive decay (with Barnes), elucidation of the uranium-radium, thorium and actinium series (Godlewski and Hahn), the radioactivity of the earth and atmosphere (Eve), the nature of the gamma rays (Eve) and, perhaps most important of all, the nature and properties of the alpha particle (Rutherford himself). The latter investigations led directly to Rutherford's later work in Manchester, including the nuclear model of the atom and artificial disintegration of the nucleus.

  2. Electronic structure and dynamics of ordered clusters with ME or RE ions on oxide surface

    Energy Technology Data Exchange (ETDEWEB)

    Kulagin, N.A., E-mail: nkulagin@bestnet.kharkov.u [Kharkiv National University for Radio Electronics, Avenue Shakespeare 6-48, 61045 Kharkiv (Ukraine)

    2011-03-15

    Selected data of ab initio simulation of the electronic structure and spectral properties of either cluster with ions of iron, rare earth or actinium group elements have been presented here. Appearance of doped Cr{sup +4} ions in oxides, Cu{sup +2} in HTSC, Nd{sup +2} in solids has been discussed. Analysis of experimental data for plasma created ordered structures of crystallites with size of about 10{sup -9} m on surface of separate oxides are given, too. Change in the spectroscopic properties of clusters and nano-structures on surface of strontium titanate crystals discussed shortly using the X-ray line spectroscopy experimental results. - Research highlights: External influence and variation of technology induce changes in valence of nl ions in compounds. Wave function of cluster presented as anti-symmetrical set of ions wave functions. The main equation describes the self-consistent field depending on state of all electrons of cluster. Level scheme of Cr{sup 4+} ions in octo- and tetra-site corresponds to doped oxides spectra after treatment. Plasma treatment effects in appearance of systems of unit crystallites with size of about 10{sup -6}-10{sup -9} m.

  3. Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution

    Science.gov (United States)

    Finn, R.; McDevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.

    2005-12-01

    In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented.

  4. Ac, La, and Ce radioimpurities in {sup 225}Ac produced in 40-200 MeV proton irradiations of thorium

    Energy Technology Data Exchange (ETDEWEB)

    Engle, Jonathan W.; Ballard, Beau D. [Los Alamos National Laboratory, NM (United States); Weidner, John W. [Air Force Institute of Technology, Wright Patterson Air Force Base, OH (United States); and others

    2014-10-01

    Accelerator production of {sup 225}Ac addresses the global supply deficiency currently inhibiting clinical trials from establishing {sup 225}Ac's therapeutic utility, provided that the accelerator product is of sufficient radionuclidic purity for patient use. Two proton activation experiments utilizing the stacked foil technique between 40 and 200 MeV were employed to study the likely co-formation of radionuclides expected to be especially challenging to separate from {sup 225}Ac. Foils were assayed by nondestructive γ-spectroscopy and by α-spectroscopy of chemically processed target material. Nuclear formation cross sections for the radionuclides {sup 226}Ac and {sup 227}Ac as well as lower lanthanide radioisotopes {sup 139}Ce, {sup 141}Ce, {sup 143}Ce, and {sup 140}La whose elemental ionic radii closely match that of actinium were measured and are reported. The predictions of the latest MCNP6 event generators are compared with measured data, as they permit estimation of the formation rates of other radionuclides whose decay emissions are not clearly discerned in the complex spectra collected from {sup 232}Th(p,x) fission product mixtures. (orig.)

  5. An Ion Exchange Study of Possible Hydridized 5f Bonding in theActinides

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, R.M.; Street, Jr., K.; Seaborg, G.T.

    1951-08-28

    A study has been made of the elution behavior of curium(III), americium(III), plutonium(III), actinium(III), plutonium(IV), neptunium(IV), uraniuM(IV), thorium(IV), neptunium(V), plutonium (VI), uranium (VI), lanthanum(III), cerium(III), europium(III), ytterbium(III), ytterium(III), strontium(II), barium(II), radium(II), cesium(I) with 3.2 M, 6.2 M, 9.3 M, and 12.2 M HCl solutions from Dowex-50 cation exchange resin columns. These elutions show that in high concentrations of hydrochloric acid the actinides form complex ions with chloride ion to a much greater extent than the lanthanides. The strengths of the tripositive actinide complex ions apparently go in the order plutonium > americium> curium, although their ionic radii also decrease in this same order. To explain these results, a partial covalent character may be ascribed to the bonding in the transuranium complex ions. It is shown that a reasonable structure for such covalent bonding involves hybridization of the 5f orbitals in the actinide elements.

  6. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  7. Pulse-shape discrimination and energy quenching of alpha particles in Cs$_2$LiLaBr$_6$:Ce$^{3+}$

    CERN Document Server

    Mesick, Katherine E; Stonehill, Laura C

    2016-01-01

    Cs$_2$LiLaBr$_6$:Ce$^{3+}$ (CLLB) is an elpasolite scintillator that offers excellent linearity and gamma-ray energy resolution and sensitivity to thermal neutrons with the ability to perform pulse-shape discrimination (PSD) to distinguish gammas and neutrons. Our investigation of CLLB has indicated the presence of intrinsic radioactive alpha background that we have determined to be from actinium contamination of the lanthanum component. We measured the pulse shapes for gamma, thermal neutron, and alpha events and determined that PSD can be performed to separate the alpha background with a moderate figure of merit of 0.98. We also measured the electron-equivalent-energy of the alpha particles in CLLB and simulated the intrinsic alpha background from $^{227}$Ac to determine the quenching factor of the alphas. A linear quenching relationship $L_{\\alpha} = E_{\\alpha} \\times q + L_0$ was found at alpha particle energies above 5 MeV, with a quenching factor $q = 0.71$ MeVee/MeV and an offset $L_0 = - 1.19$ MeVee.

  8. Liquid Scintillation Counting of Environmental Radioisotopes: A Review of the Impact of Background Reduction

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, Matthew; Bernacki, Bruce E.; Erchinger, Jennifer L.; Finn, Erin C.; Fuller, Erin S.; Hoppe, Eric W.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Orrell, John L.; Panisko, Mark E.; Warren, Glen A.; Wright, Michael E.

    2016-03-09

    Liquid scintillation counting (LSC) is a versatile and commonplace method for radiometric measurement of charged particle emitting radionuclides. The LSC method provides utility in a range of environmental science applications including hydrological studies of water transport, anthropogenic releases of radionuclides into the environment, and vertical mixing rates within oceans. Instrumental measurement background is one limiting factor of radiometric measurement sensitivity. As part of the development of a custom low background LSC system located in a shallow underground laboratory at Pacific Northwest National Laboratory, a number of measurement applications of LSC have been considered and are summarized here. The focus is on determining which aspects of such measurements would gain the greatest benefit from the reduction of LSC backgrounds by a factor of 10-100 relative to values reported in the literature. Examples of benefits include lowering the minimum detectable activity, reducing the sample size required, and shortening the elapsed timeline of the processing and analysis sequence. In particular tritium, strontium, and actinium isotopes are examined as these isotopes cover a range of requirements related to the LSC measurement method (e.g., 3H: low energy; Sr: spectral deconvolution; Ac: alpha/beta discrimination).

  9. Development of an Ultra-Low Background Liquid Scintillation Counter for Trace Level Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Erchinger, Jennifer L.; Orrell, John L.; Aalseth, Craig E.; Bernacki, Bruce E.; Douglas, Matthew; Finn, Erin C.; Fuller, Erin S.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Panisko, Mark E.; Shaff, Sarah M.; Warren, Glen A.; Wright, Michael E.

    2015-09-01

    Low-level liquid scintillation counting (LSC) has been established as one of the radiation detection techniques useful in elucidating environmental processes and environmental monitoring around nuclear facilities. The Ultra-Low Background Liquid Scintillation Counter (ULB-LSC) under construction in the Shallow Underground Laboratory at Pacific Northwest National Laboratory aims to further reduce the MDAs and/or required sample processing. Through layers of passive shielding in conjunction with an active veto and 30 meters water equivalent overburden, the background reduction is expected to be 10 to 100 times below typical analytic low-background liquid scintillation systems. Simulations have shown an expected background of around 14 counts per day. A novel approach to the light collection will use a coated hollow light guide cut into the inner copper shielding. Demonstration LSC measurements will show low-energy detection, spectral deconvolution, and alpha/beta discrimination capabilities, from trials with standards of tritium, strontium-90, and actinium-227, respectively. An overview of the system design and expected demonstration measurements will emphasize the potential applications of the ULB-LSC in environmental monitoring for treaty verification, reach-back sample analysis, and facility inspections.

  10. Purification of lanthanides for double beta decay experiments

    Energy Technology Data Exchange (ETDEWEB)

    Polischuk, O. G. [Institute for Nuclear Research, MSP 03680 Kyiv, Ukraine and INFN, Section of Rome, La Sapienza, I-00185 Rome (Italy); Barabash, A. S. [Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Belli, P. [INFN, Section of Rome Tor Vergata, I-00133 Rome (Italy); Bernabei, R. [INFN, Section of Rome Tor Vergata, I-00133 Rome, Italy and Department of Physics, University of Rome Tor Vergata, I-00133 Rome (Italy); Boiko, R. S.; Danevich, F. A.; Mokina, V. M.; Poda, D. V.; Tretyak, V. I. [Institute for Nuclear Research, MSP 03680 Kyiv (Ukraine); Cappella, F.; Incicchitti, A. [INFN, Section of Rome La Sapienza, I-00185 Rome, Italy and Department of Physics, University of Rome La Sapienza, I-00185 Rome (Italy); Cerulli, R.; Laubenstein, M.; Nisi, S. [INFN, Gran Sasso National Laboratories, I-67100 Assergi (Aq) (Italy)

    2013-08-08

    There are several potentially double beta active isotopes among the lanthanide elements. However, even high purity grade lanthanide compounds contain {sup 238}U, {sup 226}Ra and {sup 232,228}Th typically on the level of ∼ (0.1 - 1) Bq/kg. The liquid-liquid extraction technique was used to remove traces of U, Ra and Th from CeO{sub 2}, Nd{sub 2}O{sub 3} and Gd{sub 2}O{sub 3}. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe γ spectrometry at the underground Gran Sasso National Laboratories of the INFN (Italy). After the purification the radioactive contamination of gadolinium oxide by Ra and Th was decreased at least one order of magnitude. The efficiency of the approach to purify cerium oxide from Ra was on same level, while the radioactive contamination of neodymium sample before and after the purification is below the sensitivity of analytical methods. The purification method is much less efficient for chemically very similar radioactive elements like lanthanum, lutetium and actinium. R and D of the methods to remove the pollutions with improved efficiency is in progress.

  11. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin.

    Science.gov (United States)

    Nour, S; El-Sharkawy, A; Burnett, W C; Horwitz, E P

    2004-12-01

    The objective of this work was to establish a new procedure for 228Ra determination of natural waters via preconcentration of radium on MnO2 and separation of its daughter, 228Ac, using Diphonix ion exchange resin. Following removal of potential interferences via passage through an initial Diphonix Resin column, the first daughter of 228Ra, 228Ac, is isolated by chromatographic separation via a second Diphonix column. A holding time of > 30 h for 228Ac ingrowth in between the two column separations ensures secular equilibrium. Barium-133 is used as a yield tracer. Actinium-228 is eluted from the second Diphonix Resin with 5 ml 1M 1-Hydroxyethane-1,1-diphosphonic acid (HEDPA) and quantified by addition of scintillation cocktail and LSC counting. Radium (and 133Ba) from the load and rinse solutions from the 2nd Diphonix column may be prepared for alpha spectrometry (for determination of 223Ra, 224Ra, and 226Ra) by BaSO4 microprecipitation and filtration. Decontamination tests indicate that U, Th, and Ra series nuclides do not interfere with these measurements, although high contents of 90Sr (90Y) require additional treatment for accurate measurement of 228Ra. Addition of stable Sr as a "hold back" carrier during the initial MnO2 preconcentration step was shown to remove most 90Sr interference.

  12. Soil and river sediments radionuclides monitoring at Aramar Experimental Center: an historical overview

    Energy Technology Data Exchange (ETDEWEB)

    Segre, Nadia; Fagundes, Rosane Correa, E-mail: nadia.segre@ctmsp.mar.mil.br [Centro Tecnologico da Marinha (CTM-SP/CEA/LARE), Ipero, SP (Brazil). Centro Experimental Aramar. Lab. Radioecologico; Moraes, Marco Antonio P.V. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    In order to evaluate possible effects to the environment resulting from the implementation of the Centro Tecnologico da Marinha - Centro Experimental Aramar (CTMSP-CEA) at Ipero in Sao Paulo state, Brazil, which came into operation in 1989, an Environmental Monitoring Program (PMA) was established in October, 1987. One of the aims of this program is to monitor the soil and river sediments radionuclides levels at CEA and beyond its boundary. The utilization of statistical tools to evaluate the results of radiometric environmental monitoring is a procedure required by National Nuclear Energy Commission (CNEN). The box plot is a simple statistical tool for displaying data. The central tendency and dispersion of the results as well as the observation of unusual results (outliers) in the dataset are easily visualized. Control chart is a graph that maps data and provides a picture of how a process is performing over time. A control chart always has a central line for the mean, an upper line for the upper control limit and a lower line for the lower control limit. Box plots and control charts were used to visualize the annual amount of natural uranium, lead-214, actinium-228 and lead-212 in soil and river sediment detected between 1987 and 2011, considering the measurements of all monitored places each year. This historical observation shows that, in average, the results obtained are below than the 1987-1988 levels (CEA's pre-operational) or below than the backgrounds radionuclides values. (author)

  13. Background radiation and individual dosimetry in the costal area of Tamil Nadu, India.

    Science.gov (United States)

    Matsuda, Naoki; Brahmanandhan, G M; Yoshida, Masahiro; Takamura, Noboru; Suyama, Akihiko; Koguchi, Yasuhiro; Juto, Norimichi; Raj, Y Lenin; Winsley, Godwin; Selvasekarapandian, S

    2011-07-01

    South coast of India is known as the high-level background radiation area (HBRA) mainly due to beach sands that contain natural radionuclides as components of the mineral monazite. The rich deposit of monazite is unevenly distributed along the coastal belt of Tamil Nadu and Kerala. An HBRA site that laid in 2×7 m along the sea was found in the beach of Chinnavillai, Tamil Nadu, where the maximum ambient dose equivalent reached as high as 162.7 mSv y(-1). From the sands collected at the HBRA spot, the high-purity germanium semi-conductor detector identified six nuclides of thorium series, four nuclides of uranium series and two nuclides belonging to actinium series. The highest radioactivity observed was 43.7 Bq g(-1) of Th-228. The individual dose of five inhabitants in Chinnavillai, as measured by the radiophotoluminescence glass dosimetry system, demonstrated the average dose of 7.17 mSv y(-1) ranging from 2.79 to 14.17 mSv y(-1).

  14. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    NA

    2004-11-22

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this modeling activity is to predict dissolved concentrations or solubility limits for 14 elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) important to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are in the form of tabulated functions with pH and log (line integral) CO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. The output data from this report are fundamental inputs for Total System Performance Assessment for the License Application (TSPA-LA) to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for all of the actinides. These models cover broad ranges of environmental conditions so that they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or otherwise addressed.

  15. TAM类突变对B'亚型HIV病毒耐药和复制能力的影响%The impact of thymidine analogue resistance mutations on the level of drug resistance and replicative capacity of HIV-1 subtype B' viruses

    Institute of Scientific and Technical Information of China (English)

    周茜; 邢辉; 方志明; 陈彬; 王铮; 邵一鸣; 廖玲洁; 黄汉菊

    2013-01-01

    Objective To study the influence of thymidine analogue resistance mutations (TAMs) such as T215Y and L210W on antiretroviral drug resistance and replicative capacity of HIV-1 viruses under the genetic background of pol fragment of subtype B' strains.Methods The plasma sample was collected from a patient infected with HIV-1 subtype B' strains who was under antiretroviral therapy and with TAM mutations.Partial pol gene was amplified from three different viral quasispecies with single genome amplification (SGA),T215Y and L210W was reverse mutated to wild type codons by PCR based point mutation.Recombinant infectious clones were constructed by replacing pol fragment of pNL4-3-BstⅡ with counterparts from the patient's viruses.The level of drug resistance and replicative dynamics were evaluated via luciferase assay and P24 measurement.Results Three recombinant infectious clones were successfully constructed,named as pNL-PAT-1,pNL-PAT-2 and pNL-PAT-3 with mutations T215Y,M41L/L210W/T215Y and M41L/L210W/T215Y,respectively.Three corresponding infectious clones with reverse mutations at 215 and 201 positions were pNL-PAT-1-T215Y (-),pNL-PAT-2-L210W(-) and pNL-PAT-3-L210W(-).Compared with the IC50 values to AZT in the original viruses,those in the mutated viruses had been lowered for 4.9,8.1 and 2.7 times.pNL-PAT-1-T215Y(-) had a higher level of P24 in supernatant than pNL-PAT-1 did.The viruses with reverse mutation of L210W had different levels of replication as compared with the original ones:pNL-PAT-2-L210W(-) had a slightly lower level of P24 than pNL-PAT-2 did,but pNL-PAT-3-L210W(-) had a much higher level of P24 as compared with pNL-PAT-3.Conclusions TAM mutations such as T215Y and L210W can raise the resistance to AZT of subtype B' strains to certain levels.T215Y can impair viral replicative fitness.However,L210W might have different impacts on replicative capacity in different HIV-1 strains.Genetic diversity may have a role in drug resistance and viral replicative

  16. Measurement of myocardial blood flow with oxygen-15 labelled water: comparison of different administration protocols.

    Science.gov (United States)

    Hermansen, F; Rosen, S D; Fath-Ordoubadi, F; Kooner, J S; Clark, J C; Camici, P G; Lammertsma, A A

    1998-07-01

    Positron emission tomography (PET) in conjunction with C15O2 or H215O can be used to measure myocardial blood flow (MBF) and tissue fraction (TF), i.e. the fraction of the tissue mass in the volume of the region of interest. However, with C15O2 inhalation, the tissue fraction in the septum is overestimated. Bolus injection of H215O together with arterial cannulation gives very precise results but is invasive. The purpose of this study was to develop a method which circumvents these problems. A four-parameter model with parameters for MBF, TF and spill-over fractions from both left and right ventricular cavities was developed. This method was compared with a three-parameter model (no right ventricular cavity spill-over) in both septal and non-septal regions of interest for three different administration protocols: bolus injection of H215O, infusion of H215O and inhalation of C15O2. It was found that MBF can be measured with intravenous administration of H215O without the requirement for arterial cannulation. The four-parameter protocol with bolus injection was stable in clinical studies. The four-parameter model proved essential for the septum, where it gave highly significantly better fits than did the three-parameter model (P<0.00003 in each of 15 subjects). Administration of H215O together with this four-parameter model also circumvented the problem of overestimation of TF in the septum seen with C15O2 inhalation. In addition, the radiation dose of H215O protocols is lower than that of C15O2 inhalation. Using a left atrial input curve instead of a left ventricular cavity input curve gave the same mean MBF and TF.

  17. Sustained high proportion of zidovudine-resistant HIV variants despite prolonged substitution of zidovudine by other nucleoside reverse transcriptase inhibitors.

    Science.gov (United States)

    Bélec, Laurent; Legoff, Jérôme; Si-Mohamed, Ali; Andréoletti, Laurent; Mbopi-Kéou, François-Xavier; Kolberg, Janice; Matta, Mathieu; Detmer, Jill; Piketty, Christophe; Kazatchkine, Michel D

    2002-09-01

    The consequences of zidovudine (ZDV) replacement by other nucleoside reverse transcriptase inhibitors on the expression of resistance mutations at codons 215 and 41 of the reverse transcriptase (RT) gene was investigated prospectively in 66 patients harboring mutant genotypes who were changed to an effective two- or three-drug combination antiretroviral regimen. Quantitation of mutant (MUT) viral populations at codon 215 by means of RT-PCR with differential hybridization of amplicons specific for MUT and wild (WT) variants revealed no difference in the proportion of 215 MUT variants prior to (93.5 +/- 2.4%) and 12 to 20 months after (96.9 +/- 1.9%) ZDV replacement, independently of a therapeutic change for stavudine. The fitness of the variants harboring the ZDV-resistant MUT 215 genotype following drug withdrawal was calculated to be 96 to 99% of that of the variants harboring the WT 215 genotype. The apparent stability of ZDV-resistant variants in the study population may have two main complementary explanations: persistent selective pressure secondary to partial cross-resistance due to the new regimens given after the therapeutic alteration and suppression of viral replication after the therapeutic alteration that could have hampered the replacement of less fit variants by fitter variants. These findings indicate that, at least within 15 months following discontinuation of ZDV, an effective antiretroviral therapy is insufficient to allow for ZDV-resistant strains to disappear, and thus to allow for the safe re-introduction of the drug.

  18. Prevalence of drug resistance mutations and non-B subtypes in newly diagnosed HIV-1 patients in Denmark

    DEFF Research Database (Denmark)

    Jørgensen, Louise B; Christensen, Marianne B; Gerstoft, Jan

    2003-01-01

    The aim of this study was to monitor the prevalence of drug resistance mutations in newly diagnosed HIV-1 positive individuals in Denmark. In addition we assessed the prevalence of non-B subtypes based on phylogenetic analysis of the pol gene. Plasma samples from 104 newly diagnosed HIV-1 positive...... patients were obtained in the year 2000. The entire protease gene and 320 amino acids of the reverse transcriptase gene were genotyped. Sequences were obtained from 97 patients. No subjects displayed primary resistance mutations in the protease gene, whereas all carried 1 or more secondary mutations....... Resistance mutations in the RT-gene associated with NRTI-resistance were found in 1 patient, who was infected with zidovudine resistant HIV-1 harbouring the M41L mutation in combination with T215S and L210S. The T215S mutation has been showed to be associated with reversion of zidovudine resistance. The T215...

  19. Dicty_cDB: FC-IC0522 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC0522 (Link to dictyBase) - G24294 DDB0169466 Contig-U03376-1 FC-IC... (Link to library) Clone ID FC-IC0522 (Link to dictyBase) Atlas ID - NBRP ID G24294 dic...tnfski*ki rniyklsislc Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value FC-IC0522 (FC-IC... 12.0 %: cytoskeletal 8.0 %: mitochondrial 4.0 %: vacuolar >> prediction for FC-IC...0522E (Link to Original site) FC-IC0522F 215 FC-IC0522Z 215 FC-IC0522P 430 FC-IC0522E 215 Show FC-IC0522 Library FC-IC

  20. NCBI nr-aa BLAST: CBRC-TTRU-01-0536 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0536 ref|YP_002830310.1| hypothetical protein M1425_2279 [Sulfolobus isla...ndicus M.14.25] ref|YP_002833062.1| hypothetical protein LS215_2446 [Sulfolobus islandicus L.S.2.15] ref|...YP_002844262.1| hypothetical protein M1627_2358 [Sulfolobus islandicus M.16.27] ref|YP_002915550.1| hypothet...ical protein M164_2280 [Sulfolobus islandicus M.16.4] gb|ACP36417.1| conserved hy...pothetical protein [Sulfolobus islandicus L.S.2.15] gb|ACP39012.1| conserved hypothetical protein [Sulfolobus isla

  1. Ultra-broadband THz time-domain spectroscopy of common polymers using THz air photonics

    DEFF Research Database (Denmark)

    D’Angelo, Francesco; Mics, Zoltán; Bonn, Mischa

    2014-01-01

    Terahertz-range dielectric properties of the common polymers low-density polyethylene (LDPE), cyclic olefin/ethylene copolymer (TOPAS®), polyamide-6 (PA6), and polytetrafluoroethylene (PTFE or Teflon®) are characterized in the ultra-broadband frequency window 2-15 THz, using a THz time-domain spe......Terahertz-range dielectric properties of the common polymers low-density polyethylene (LDPE), cyclic olefin/ethylene copolymer (TOPAS®), polyamide-6 (PA6), and polytetrafluoroethylene (PTFE or Teflon®) are characterized in the ultra-broadband frequency window 2-15 THz, using a THz time...... and PTFE, and their dielectric functions in the complete frequency window 2-15 THz are theoretically reproduced. Our results demonstrate the potential of ultrabroadband air-photonics-based THz time domain spectroscopy as a valuable analytic tool for materials science....

  2. Clinical analysis of chemotherapy on secondary diabetes of breast cancer patients treated with taxanes agent%紫杉类化疗方案治疗乳腺癌继发糖尿病的相关分析

    Institute of Scientific and Technical Information of China (English)

    徐方贵; 吴德柱; 王剑平; 杜京丽; 支波波; 林雨冬

    2014-01-01

    Objective:To observate the affect of taxanes agent chemotheraPy on the blood glucose of Patients with breast cancer. Methods:The data of 215 breast cancer Patients treated in our hosPital from January 2009 to June 2013 were obtained. The change of their blood glucose and correlated clinical data before and after chemotheraPy were retro-sPectively analyzed. Results:During chemotheraPy,15 cases develoPed secondary diabetes(15 / 215,6. 98% ),second-ary diabetes develoPed after chemotheraPy in 9 cases(9 / 215,4. 19% ). Their age were over 50 years old,19 cases aP-Peared glucosuria abnormal(19 / 215,8. 84% ),which aPPeared during chemotheraPy in 12 cases(12 / 215,5. 58% ),7 cases(7 / 215,3. 26% )after chemotheraPy,1 case of Poor blood sugar control for diabetes comPlications after chemo-theraPy dead,4. 17%(1 / 24),19 cases of Patients after diet control and Physical theraPy in 11 cases of fasting blood glucose levels back to normal(11 / 19,57. 89% ). Conclusion:For Patients with breast cancer treated with taxanes a-gent chemotheraPy can develoP secondary diabetes,there is certain correlation between them.%目的:观察紫杉类方案化疗对乳腺癌患者血糖的影响。方法:回顾性分析我院2009年1月-2013年6月收治的215例乳腺癌患者化疗前后的血糖变化情况及相关临床资料。结果:化疗期间出现继发性糖尿病15例(15/215,6.98%),化疗后出现继发性糖尿病9例(9/215,4.19%),其年龄均大于50岁;19例出现空腹血糖调节受损(19/215,8.84%),其中化疗期间出现12例(12/215,5.58%),化疗后出现7例(7/215,3.26%);1例继发性糖尿病患者血糖控制不好因酮症酸中毒而于化疗后10个月死亡(1/24,4.17%),19例空腹血糖调节受损患者中经过饮食控制及物理治疗11例空腹血糖水平恢复到正常水平(11/19,57.89%)。结论:乳腺癌患者应用紫杉类化疗方案化疗与继发性糖尿病或空腹血糖调节受损

  3. Lactobacillus formosensis sp. nov., a lactic acid bacterium isolated from fermented soybean meal.

    Science.gov (United States)

    Chang, Chi-huan; Chen, Yi-sheng; Lee, Tzu-tai; Chang, Yu-chung; Yu, Bi

    2015-01-01

    A Gram-reaction-positive, catalase-negative, facultatively anaerobic, rod-shaped lactic acid bacterium, designated strain S215(T), was isolated from fermented soybean meal. The organism produced d-lactic acid from glucose without gas formation. 16S rRNA gene sequencing results showed that strain S215(T) had 98.74-99.60 % sequence similarity to the type strains of three species of the genus Lactobacillus (Lactobacillus farciminis BCRC 14043(T), Lactobacillus futsaii BCRC 80278(T) and Lactobacillus crustorum JCM 15951(T)). A comparison of two housekeeping genes, rpoA and pheS, revealed that strain S215(T) was well separated from the reference strains of species of the genus Lactobacillus. DNA-DNA hybridization results indicated that strain S215(T) had DNA related to the three type strains of species of the genus Lactobacillus (33-66 % relatedness). The DNA G+C content of strain S215(T) was 36.2 mol%. The cell walls contained peptidoglycan of the d-meso-diaminopimelic acid type and the major fatty acids were C18 : 1ω9c, C16 : 0 and C19 : 0 cyclo ω10c/C19 : 1ω6c. Phenotypic and genotypic features demonstrated that the isolate represents a novel species of the genus Lactobacillus, for which the name Lactobacillus formosensis sp. nov. is proposed. The type strain is S215(T) ( = NBRC 109509(T) = BCRC 80582(T)).

  4. Early Paleogene variations in the calcite compensation depth: new constraints using old boreholes across Ninetyeast Ridge in the Indian Ocean

    Directory of Open Access Journals (Sweden)

    B. S. Slotnick

    2014-08-01

    Full Text Available Major variations in global carbon cycling occurred between 62 and 48 Ma. To better constrain the cause and magnitude of these changes, the community needs early Paleogene carbon isotope and carbonate accumulation records from widely separated deep-sea sediment sections, especially including the Indian Ocean. With the potential for renewed scientific drilling in the Indian Ocean, we examine lithologic, nannofossil assemblage, carbon isotope, and carbonate content records for late Paleocene – early Eocene sediment recovered at three existing sites spanning Ninetyeast Ridge: Deep Sea Drilling Project (DSDP Sites 213 (deep, east, 214 (shallow, central, and 215 (deep, west. The sediment sections are not ideal, because they were recovered in single holes using rotary coring methods. Site 214 was very shallow during the late Paleocene, when it received significant amounts of neritic carbonate. The δ13C records at Sites 213 and 215 are similar to those generated at several locations in the Atlantic and Pacific. The prominent high in δ13C across the Paleocene carbon isotope maximum (PCIM occurs at Site 215, and the prominent low in δ13C across the early Eocene Climatic Optimum (EECO occurs at both Site 213 and Site 215. The Paleocene–Eocene thermal maximum (PETM and the K/X event are found at Site 213 but not at Site 215, presumably because of coring gaps. Carbonate content at both Sites 213 and 215 drops to Discoaster lodoensis and the early Eocene rise in δ13C (~ 52 Ma. This reflects a rapid shoaling of the calcite compensation depth (CCD, and likely a major decrease in the net flux of 13C-depleted carbon to the ocean. Our work further constrains knowledge of the early Paleogene CCD, but more importantly suggests that excellent early Paleogene carbonate accumulation records might be recovered from the central Indian Ocean with future scientific drilling.

  5. Comparisons: Technical-Tactical and Time-Motion Analysis of Mixed Martial Arts by Outcomes.

    Science.gov (United States)

    Miarka, Bianca; Vecchio, Fabrício B D; Camey, Suzi; Amtmann, John A

    2016-07-01

    Miarka, B, Vecchio, FBD, Camey, S, and Amtmann, JA. Comparisons: technical-tactical and time-motion analysis of mixed martial arts by outcomes. J Strength Cond Res 30(7): 1975-1984, 2016-The aim of this study was to compare time-motion and technical-tactical analysis between paired outcomes and rounds of mixed martial arts (MMA) matches. The sample consisted of 645 rounds of MMA competition paired by outcomes (first round, winners n = 215 and losers n = 215; second round, winners n = 215 and losers n = 215; third round, winners n = 215 and losers n = 215). The time-motion variables were categorized into low-intensity or high-intensity, stand-up or groundwork situations. Stand-up techniques were analyzed by observing total strikes to the head and body, and takedowns. The actions on the ground were analyzed by observing submission activity, including successful choking and joint locking actions, and also positional improvements, including advances to the mount, half guard, and side and back positions. Chi-squared and Wilcoxon tests were conducted with a significance level of p ≤ 0.05. Results showed that winners had higher values for total strikes and submissions in all rounds, and also positional improvements, over losers. The standing combat with low-intensity comparisons presented differences between the rounds first, with a median of 2:33.5 (P25-P75%: 1:20-3:56) minute, second, with 2:37 (1:24-3:59) minute, and third, with 2:07 (1:06-3:39.2) minute. These data suggest a focus on the intermittent demand presented in combat phases with a special attention to the strike and ground technical-tactical skills; strength and conditioning coaches could emphasize the effort pause ratios for both standing and ground combat that mimic the requirements of MMA, especially during the third round.

  6. Conformal Geometry, Hotine’s Conjecture, and Differential Geodesy.

    Science.gov (United States)

    1987-07-27

    satisfied. We now check that the equations of Gauss and Mainardi -Codazzi rv~. hold in V3 i.e., ~4 3 10 .1 .1 - J * (2.15) Rt 3 b bm -b bA + Rhijkx xf3...8217xX6 ,1 0’ % (2.16) b -b -h 1 i j k 0 (T[3; (r YfW Rhijk 0 1 X Equation (2.15) is the Gauss equation and (2.16) are the equations of j Mainardi -Codazzi

  7. Mitochondrial neurogastrointestinal encephalomyopathy: novel pathogenic mutations in thymidine phosphorylase gene in two Italian brothers.

    Science.gov (United States)

    Libernini, Laura; Lupis, Chiara; Mastrangelo, Mario; Carrozzo, Rosalba; Santorelli, Filippo Maria; Inghilleri, Maurizio; Leuzzi, Vincenzo

    2012-08-01

    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE, MIM 603041) is an autosomal recessive multisystem disorder occurring due to mutations in a nuclear gene coding for the enzyme thymidine phosphorylase (TYMP). Clinical features of MNGIE include gastrointestinal dysmotility, cachexia, ptosis or ophthalmoparesis, peripheral neuropathy, diffuse leukoencephalopathy, and signs of mitochondrial dysfunction in tissues. We report the clinical and molecular findings in two brothers in whom novel TYMP gene mutations (c.215-13_215delinsGCGTGA; c.1159 + 2T > A) were associated with different clinical presentations and outcomes.

  8. Structural rearrangement in gas phase niobium carbide clusters, NbnC3 and NbnC6

    Science.gov (United States)

    Miyajima, Ken; Sobhan, Mushtaq Ahmed; Hardy, Robert A.; Metha, Gregory F.; Mafuné, Fumitaka

    2015-08-01

    Niobium carbide clusters were formed in the gas phase by mixing vapors of niobium and carbon. When a carbon trimer, C3, was richly formed in the vapor, clusters with compositions NbnC3k+ (n = 2-10, k = 0-4) were abundantly observed after photoionization at 215 nm, enabling the presumption that a C3 unit could be a building block of the observed clusters. Contrary to this presumption, photoionization efficiency spectra in 215-286 nm suggest that the clusters should be assigned to atomically mixed niobium carbide. Structural rearrangement of the clusters into the atomically mixed form is consistent with the results of DFT calculations.

  9. AcEST: DK949553 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 7R8C8|A7R8C8_VITVI Chromosome undetermined scaffold_2450, wh... 42 0.027 tr|A7QX9...1|A7QX91_VITVI Chromosome undetermined scaffold_215, who... 42 0.027 tr|Q9SFV3|Q9SFV3_ARATH Putative wound-i...FLSQKGG++D+R Sbjct: 1 MIYDVNSPLFRSFLSQKGGSSDKR 24 >tr|A7R8C8|A7R8C8_VITVI Chromosome undetermined scaffold_2...GGSSDKR 24 >tr|A7QX91|A7QX91_VITVI Chromosome undetermined scaffold_215, whole genome shotgun sequence OS=Vi

  10. A New Immunologic Method for Detection of Occult Breast Cancer

    Science.gov (United States)

    1999-09-01

    215, 1988. 29 P.I., Rishab K. Gupta, Ph.D. 38. Repetto L, Onetto M, Gardin G, Costanzi B, Guidici S, Vitiello E, Merlini L, Naso C, Zannini C...Serum CA15-3 assay in the diagnosis and follow-up of breast cancer. BrJ Cancer 58: 213-215, 1988. 40. Repetto L, Onetto M, Gardin G, Costanzi B... REPETTO L, ONETTO M, GARDIN G, et al: Serum CEA, CA15-3, and MCA in breast cancer patients: A clinical evaluation. Cancer Detection & Prevention 17:411

  11. GETDB: 112090 [GETDB

    Lifescience Database Archive (English)

    Full Text Available 112090 Link to Original w[*]; P{GawB}NP0215 / TM6, P{UAS-lacZ.UW23-1}UW23-1 82C4 Li...nk to DGRC Genome Viewer: 112090 5-HT2 CG12587 1360{}1206 215 3 NP line. Received from the National Institut...lls, sg uniform epi, tr sg, gut, tr - semi lethal - - d1 - - - Show 112090 DGRC Number 1120...C4 Map Viewer Link to DGRC Genome Viewer: 112090 Related Genes 5-HT2 CG12587 1360{}1206 Original Number 215

  12. Conscription in the Afghan Army. Compulsory Service Versus an All Volunteer Force

    Science.gov (United States)

    2011-04-01

    of Developing Nations: A Comparative Analysis oflndia and Nigeria ," Aimed Forcesand Society, Vol. 19, No. 1 Fall 1992, pp. 123-137 (131). 70 Barua...Military of Developing Nations: A Compara- tive Analysis of India and Nigeria ," Armed Eorces and Society, Vol. 19, No. 1, Fall 1992. "Egypt Protests: Army...Camp Leather - neck, 03 Dec 2010 Members of 215’’’ Corps Embedded Advisor Team, Camp Shorabak, 03 Dec 2010 Advisor to 215" Corps Inspector General, Camp Shorabak, 03 Dec 2010 58

  13. 40 CFR 464.25 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ....0168 Lead (T) 0.0211 0.0104 Zinc (T) 0.0303 0.0116 TTO 0.0335 0.0109 Oil and grease (for alternate....545 0.208 Total phenols 0.617 0.215 TTO 1.65 0.54 Oil and grease (for alternate monitoring) 21.5 7.18... (T) 8.37 3.19 TTO 25.4 8.29 Oil and grease for alternate monitoring) 330 110 (f) Melting...

  14. Drug: D01952 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01952 Drug L-Methylephedrine hydrochloride (JAN) C11H17NO. HCl 215.1077 215.7197 D...hodopsin family Adrenaline alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135] Methylephedrine D01952 L-Methylephe...A:150 151 152] [KO:K04138 K04139 K04140] Methylephedrine D01952 L-Methylephedrine hydrochloride (JAN) beta1-...adrenergic receptor [HSA:153] [KO:K04141] Methylephedrine D01952 L-Methylephedrine hydrochloride (JAN) beta2...-adrenergic receptor [HSA:154] [KO:K04142] Methylephedrine D01952 L-Methylephedrine hydrochloride (JAN) beta

  15. EST Table: FS761536 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available /10 40 %/215 aa gi|91083987|ref|XP_975212.1| PREDICTED: similar to asteroid CG4426-PA [Tribolium castaneum] FS761536 fcaL ... ...FS761536 E_FL_fcaL_17N06_F_0 11/12/09 n.h 10/09/28 40 %/215 aa ref|XP_975212.1| PREDICTED: similar to astero...id CG4426-PA [Tribolium castaneum] gb|EFA04435.1| hypothetical protein TcasGA2_TC01

  16. Recurrent mesoproterozoic continental magmatism in South-Central Norway

    DEFF Research Database (Denmark)

    Pedersen, Svend; Andersen, Tom; Konnerup-Madsen, Jens

    2009-01-01

    We report U-Pb dates and Lu-Hf isotope data, obtained by LAM-ICPMS, for zircons from metamorphic rocks of the Setesdalen valley, situated in the Telemark block south of the classic Telemark region of southern Norway. The samples include infracrustal rocks from the metamorphic basement, metaigneous...... increased with time. Around 1,320 Ma, further addition of juvenile material occurred, involving both mafic and felsic melts, metamorphism and deformation. Acid magmas with high FeO*/MgO were intruded at 1,215 Ma, coinciding with underplating elsewhere in South Norway. The period starting at 1,215 Ma...

  17. Modification of the activity of an alpha-amylase from Bacillus licheniformis by several surfactants

    OpenAIRE

    2006-01-01

    The influence of different commercial surfactants on the enzymatic activity of a commercial alpha-amylase from Bacillus licheniformis (Termamyl 300 L) has been studied. As non-ionic surfactants, alkyl polyglycosides (Glucopon® 215, Glucopon® 600 and Glucopon® 650) were studied, as were fatty alcohol ethoxylates (Findet 1214N/23 and Findet 10/15), and nonyl phenol ethoxylate (Findet 9Q/21.5NF). Also, an anionic surfactant, linear alkyl benzene sulfonate (LAS) was assayed. In general, none of t...

  18. A survey of arsenic, manganese, boron, thorium, and other toxic metals in the groundwater of a West Bengal, India neighbourhood.

    Science.gov (United States)

    Bacquart, Thomas; Bradshaw, Kelly; Frisbie, Seth; Mitchell, Erika; Springston, George; Defelice, Jeffrey; Dustin, Hannah; Sarkar, Bibudhendra

    2012-07-01

    Around 150 million people are at risk from arsenic-contaminated groundwater in India and Bangladesh. Multiple metal analysis in Bangladesh has found other toxic elements above the World Health Organization (WHO) health-based drinking water guidelines which significantly increases the number of people at risk due to drinking groundwater. In this study, drinking water samples from the Bongaon area (North 24 Parganas district, West Bengal, India) were analyzed for multiple metal contamination in order to evaluate groundwater quality on the neighbourhood scale. Each sample was analyzed for arsenic (As), boron (B), barium (Ba), chromium (Cr), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), and uranium (U). Arsenic was found above the WHO health-based drinking water guideline in 50% of these tubewells. Mn and B were found at significant concentrations in 19% and 6% of these tubewells, respectively. The maps of As, Mn, and B concentrations suggest that approximately 75% of this area has no safe tubewells. The concentrations of As, Mn, B, and many other toxic elements are independent of each other. The concentrations of Pb and U were not found above WHO health-based drinking water guidelines but they were statistically related to each other (p-value = 0.001). An analysis of selected isotopes in the Uranium, Actinium, and Thorium Radioactive Decay Series revealed the presence of thorium (Th) in 31% of these tubewells. This discovery of Th, which does not have a WHO health-based drinking water guideline, is a potential public health challenge. In sum, the widespread presence and independent distribution of other metals besides As must be taken into consideration for drinking water remediation strategies involving well switching or home-scale water treatment.

  19. Evaluation of naturally occurring radioactive materials (NORMs) in inorganic and organic oilfield scales from the Middle East.

    Science.gov (United States)

    Bassioni, Ghada; Abdulla, Fareed; Morsy, Zeinab; El-Faramawy, Nabil

    2012-04-01

    The distribution of natural nuclide gamma-ray activities and their respective annual effective dose rates, produced by potassium-40 (⁴⁰K), uranium-238 (²³⁸U), thorium-232 (²³²Th), and radium-226 (²²⁶Ra), were determined for 14 oilfield scale samples from the Middle East. Accumulated radioactive materials concentrate in tubing and surface equipment, and workers at equipment-cleaning facilities and naturally occurring radioactive materials (NORMs) disposal facilities are the population most at risk for exposure to NORM radiation. Gamma-spectra analysis indicated that photo-gamma lines represent the parents of 10 radioactive nuclides: ²³⁴Th, plutonium-239, actinium-228, ²²⁶Ra, lead-212 (²¹²Pb), ²¹⁴Pb, thallium-238 (²⁰⁸Tl), bismuth-212 (²¹²Bi), ²¹⁴Bi, and ⁴⁰K. These nuclides represent the daughters of the natural radioactive series ²³⁸U and ²³²Th with ⁴⁰K as well. The mean activity concentration of ²³⁸U, ²³²Th, and ⁴⁰K were found to be 25.8 ± 11.6, 18.3 ± 8.1, and 4487.2 ± 2.5% Bq kg⁻¹ (average values for 14 samples), respectively. The annual effective dose rates and the absorbed doses in air, both indoor and outdoor, for the samples were obtained as well. The results can be used to assess the respective hazard on workers in the field and represent a basis for revisiting current engineering practices.

  20. Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization.

    Directory of Open Access Journals (Sweden)

    Jaspreet Singh Jaggi

    Full Text Available BACKGROUND: Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen and drug delivery and results in radiotherapy and chemotherapy resistance, respectively. Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature. METHODOLOGY AND PRINCIPAL FINDINGS: Actinium-225 ((225Ac-E4G10, an alpha-emitting antibody construct reactive with the unengaged form of vascular endothelial cadherin, is capable of potent, selective killing of tumor neovascular endothelium and late endothelial progenitors in bone-marrow and blood. No specific normal-tissue uptake of E4G10 was seen by imaging or post-mortem biodistribution studies in mice. In a mouse-model of prostatic carcinoma, (225Ac-E4G10 treatment resulted in inhibition of tumor growth, lower serum prostate specific antigen level and markedly prolonged survival, which was further enhanced by subsequent administration of paclitaxel. Immunohistochemistry revealed lower vessel density and enhanced tumor cell apoptosis in (225Ac-E4G10 treated tumors. Additionally, the residual tumor vasculature appeared normalized as evident by enhanced pericyte coverage following (225Ac-E4G10 therapy. However, no toxicity was observed in vascularized normal organs following (225Ac-E4G10 therapy. CONCLUSIONS: The data suggest that alpha-particle immunotherapy to neovasculature, alone or in combination with sequential chemotherapy, is an effective approach to cancer therapy.

  1. An aerial radiological survey of the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Hendricks, T J; Riedhauser, S R

    1999-12-01

    A team from the Remote Sensing Laboratory conducted an aerial radiological survey of the US Department of Energy's Nevada Test Site including three neighboring areas during August and September 1994. The survey team measured the terrestrial gamma radiation at the Nevada Test Site to determine the levels of natural and man-made radiation. This survey included the areas covered by previous surveys conducted from 1962 through 1993. The results of the aerial survey showed a terrestrial background exposure rate that varied from less than 6 microroentgens per hour (mR/h) to 50 mR/h plus a cosmic-ray contribution that varied from 4.5 mR/h at an elevation of 900 meters (3,000 feet) to 8.5 mR/h at 2,400 meters (8,000 feet). In addition to the principal gamma-emitting, naturally occurring isotopes (potassium-40, thallium-208, bismuth-214, and actinium-228), the man-made radioactive isotopes found in this survey were cobalt-60, cesium-137, europium-152, protactinium-234m an indicator of depleted uranium, and americium-241, which are due to human actions in the survey area. Individual, site-wide plots of gross terrestrial exposure rate, man-made exposure rate, and americium-241 activity (approximating the distribution of all transuranic material) are presented. In addition, expanded plots of individual areas exhibiting these man-made contaminations are given. A comparison is made between the data from this survey and previous aerial radiological surveys of the Nevada Test Site. Some previous ground-based measurements are discussed and related to the aerial data. In regions away from man-made activity, the exposure rates inferred from the gamma-ray measurements collected during this survey agreed very well with the exposure rates inferred from previous aerial surveys.

  2. Alpha-emitting isotopes and chromium in a coastal California aquifer

    Science.gov (United States)

    Densmore, Jill N.; Izbicki, John A.; Murtaugh, Joseph M.; Swarzenski, Peter W.; Bullen, Thomas D.

    2014-01-01

    The unadjusted 72-h gross alpha activities in water from two wells completed in marine and alluvial deposits in a coastal southern California aquifer 40 km north of San Diego were 15 and 25 picoCuries per liter (pCi/L). Although activities were below the Maximum Contaminant Level (MCL) of 15 pCi/L, when adjusted for uranium activity; there is concern that new wells in the area may exceed MCLs, or that future regulations may limit water use from the wells. Coupled well-bore flow and depth-dependent water-quality data collected from the wells in 2011 (with analyses for isotopes within the uranium, actinium, and thorium decay-chains) show gross alpha activity in marine deposits is associated with decay of naturally-occurring 238U and its daughter 234U. Radon activities in marine deposits were as high as 2230 pCi/L. In contrast, gross alpha activities in overlying alluvium within the Piedra de Lumbre watershed, eroded from the nearby San Onofre Hills, were associated with decay of 232Th, including its daughter 224Ra. Radon activities in alluvium from Piedra de Lumbre of 450 pCi/L were lower than in marine deposits. Chromium VI concentrations in marine deposits were less than the California MCL of 10 μg/L (effective July 1, 2014) but δ53Cr compositions were near zero and within reported ranges for anthropogenic chromium. Alluvial deposits from the nearby Las Flores watershed, which drains a larger area having diverse geology, has low alpha activities and chromium as a result of geologic and geochemical conditions and may be more promising for future water-supply development.

  3. 77 FR 73049 - Notice of Availability of the Draft Environmental Impact Statement for the Continental Divide...

    Science.gov (United States)

    2012-12-07

    ... the Carbon County Public Library, 215 West Buffalo Street, 117, Rawlins, Wyoming 82301; and at the... Resource Protection--This alternative identifies those resources that may be most at risk from natural gas development, defines areas within the CD-C project area where those resource risks are likely to occur,...

  4. Flow visualization of swept wing boundary layer transition

    NARCIS (Netherlands)

    Serpieri, J.; Kotsonis, M.

    2015-01-01

    In this work the flow visualization of the transition pattern occurring on a swept wing in a subsonic flow is presented. This is done by means of fluorescent oil flow technique and boundary layer hot-wire scans. The experiment was performed at Reynolds number of 2:15 . 106 and at angle of attack of

  5. 76 FR 2905 - FY2011 Supplemental Funding for Brownfields Revolving Loan Fund (RLF) Grantees

    Science.gov (United States)

    2011-01-18

    ... number/ E-mail EPA Region 1, Diane Kelley, CT, ME, MA, NH, One Congress Street, Kelley.Diane@epa.gov . RI... (212) 637-3260, Fax (212) 637-4360. EPA Region 3, Tom Stolle, DE, DC, MD, PA, 1650 Arch Street, Stolle.Tom@epa.gov . VA, WV. Mail Code 3HS51, Philadelphia, Pennsylvania 19103, Phone (215) 814- 3129,...

  6. EST Table: BP121297 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BP121297 ceN-4665 10/09/28 44 %/215 aa ref|XP_001649323.1| n-acetylgalactosaminyltr...actosaminyltransferase#status:Confirmed#UniProt :O61397#protein_id:AAF60620.1 10/09/10 41 %/212

  7. 21 CFR 1304.06 - Records and reports for electronic prescriptions.

    Science.gov (United States)

    2010-04-01

    ...) The internal audit trail and any auditable event identified by the internal audit as required by... prescription as received as required by § 1311.210 of this chapter. (3) The internal audit trail and any auditable event identified by the internal audit as required by § 1311.215 of this chapter. (d) A...

  8. Domain Modeling: NP_653266.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_653266.2 chr11 Crystal structure of alkylhydroperoxidase AhpD core: uncharacteri...zed peroxidase-related protein (YP_296737.1) from Ralstonia eutropha JMP134 at 2.15 A resolution c2prrl_ chr11/NP_653266.

  9. Predicting Child Outcomes from Preschool Quality in Portugal

    Science.gov (United States)

    Abreu-Lima, Isabel M. P.; Leal, Teresa B.; Cadima, Joana; Gamelas, Ana Madalena

    2013-01-01

    The main purpose of this study is to analyze whether quality of preschool classrooms relates to 4- and 5-year-old children developmental outcomes. The study was conducted in 60 classrooms in Porto Metropolitan Area, Portugal. Children (N = 215) were evaluated in the literacy, math, and behavior domains. Preschool quality was assessed through…

  10. 75 FR 29894 - Approval and Promulgation of Air Quality Implementation Plans; District of Columbia...

    Science.gov (United States)

    2010-05-28

    ..., Washington, DC 20002. FOR FURTHER INFORMATION CONTACT: Martin Kotsch, (215) 814-3335, or by e-mail at kotsch.martin@epa.gov . SUPPLEMENTARY INFORMATION: Throughout this document whenever ``we,'' ``us,'' or ``our... a copy of the rule, to each House of the Congress and to the Comptroller General of the...

  11. University Students' Problematic Internet Use and Communication Skills According to the Internet Use Purposes

    Science.gov (United States)

    Ceyhan, Aydogan Aykut

    2011-01-01

    This study was carried out to investigate whether the levels of university students' problematic internet use and of perceived communication skills differ with respect to their basic internet use purposes. The participants were 411 university students [215 of whom were females (52.30%) and 196 of whom were males (47.70%)]. In the study, the…

  12. Highly birefringent photonic crystal fiber with ultra-flattened negative dispersion over S + C + L + U bands

    DEFF Research Database (Denmark)

    Habib, Selim; Khandker, Emran

    2015-01-01

    + C + L + U wavelength bands and average dispersion of about −558.96 ps∕nm∕km with absolute dispersion variation of 9.7 ps∕nm∕km from 1460 to 1675 nm (215 nm bandwidth). Moreover, ultrahigh birefringence of 0.0299 is also achieved at a 1500 nm wavelength. © 2015 Optical Society of America...

  13. Childrearing Attitude Assessment as a Prelude to Integrating Foreign Families.

    Science.gov (United States)

    Strom, Robert; And Others

    1983-01-01

    Assessed childrearing attitudes of 155 West German parents and 215 immigrant parents to West Germany from Greece, Italy, and Turkey. Subset comparisons indicate the need for parent-education programs that inform each group about attitude similarities as well as differences and that support family cohesion while integration proceeds. (Author/JAC)

  14. 75 FR 36461 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

    Science.gov (United States)

    2010-06-25

    ... an encryption method that meets industry standards for strong encryption; and (2) to provide FINRA staff with the confidential process or key regarding the encryption in a communication separate from the....215 (Security Measures for Data Collector that Accepts Payment Card; Use of Encryption; Liability...

  15. Prevalence of thyroid dysfunction in patients with diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Sriram Shanmugam

    2015-12-01

    Conclusions: The prevalence of thyroid dysfunction among type 2 Diabetes Mellitus patients is very high (21.5 % with subclinical hypothyroidism is being most common. Screening of thyroid dysfunction should be done in all diabetic patients especially in patients with poor diabetic control. [Int J Res Med Sci 2015; 3(12.000: 3629-3633

  16. Condition-Based Maintenance (CBM): A Working Partnership between Government, Industry, and Academia

    Science.gov (United States)

    2006-06-01

    HOUSINGASSEMBLY MR Upper Mast Bearing 3110-01-215-4794 7-311411202-5 BEARINGROLLER, TAPERED MR Lo 3110-01-179-7335 7-114110011 BEARINGROLLER, TAPERED ...objectives, realistic, and time-bound. Jim O’Brien, University of Kentucky Associate Basketball Coach, once remarked, "Excellence is the unlimited ability

  17. Reference: LEGUMINBOXLEGA5 [PLACE

    Lifescience Database Archive (English)

    Full Text Available LEGUMINBOXLEGA5 Shirsat A, Wilford N, Croy R, Boulter D Sequences responsible for t...he tissue specific promoter activity of a pea legumin gene in tobacco. Mol Gen Genet 215:326-331 (1989) PubMed: 2710102; ...

  18. Evaluation of Methodologies for Estimating Vulnerability to Electromagnetic Pulse Effects

    Science.gov (United States)

    1984-01-01

    statistics, as studied by Shewhart t1939), WilLs (1941), dnd Wald ae: Wolfowitz (1946). There is some evidence that the authors of the EC-135 report realized... Wolfowitz . 1946. Tolerance limits for a normal distribution. Annals of Mathematical Statistics 17:208-215. Wilks, S. S. 1941. On the determination of

  19. Corrections and clarifications.

    Science.gov (United States)

    1992-09-18

    The last two sentences of the second paragraph of the report by Peter R. Buseck et al. (10 July, p. 215) should have read, "We subsequently confirmed the presence of C(60) and C(70) by mass spectrometry. They occur within fracture-filling films in shungite, an unusual carbonaceous rock found near the town of Shunga in Karelia, Russia."

  20. Hybrid War Beyond Lebanon: Lessons from the South African Campaign 1976 to 1989

    Science.gov (United States)

    2009-05-01

    the Desert,215-226. For the UW operations in this phase see Piet Nortje, 32 Battalion The Inside Story of South Africa’s Elite Fighting Unit ( Capetown ...Nortje, Piet. 32 Battalion: The Inside Story of South Africa’s Elite Fighting Unit. Capetown , South Africa: Zebra Press, 2004. Norval, Morgan. Death