WorldWideScience

Sample records for actinium 213

  1. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the

  2. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    International Nuclear Information System (INIS)

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  3. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  4. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  5. Separation of Actinium 227 from the uranium minerals

    International Nuclear Information System (INIS)

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  6. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  7. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  8. Spectroscopic and computational investigation of actinium coordination chemistry.

    Science.gov (United States)

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  9. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  10. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    International Nuclear Information System (INIS)

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  11. 32 CFR 213.5 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 213.5 Section 213.5 National... SUPPORT FOR NON-FEDERAL ENTITIES AUTHORIZED TO OPERATE ON DOD INSTALLATIONS § 213.5 Responsibilities. (a... of non-Federal entities on DoD installations. (3) Assign responsibilities to the DoD Components...

  12. 12 CFR 213.7 - Advertising.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Advertising. 213.7 Section 213.7 Banks and... (REGULATION M) § 213.7 Advertising. (a) General rule. An advertisement for a consumer lease may state that a... paragraph (d)(1) of this section shall also state the following items: (i) That the transaction...

  13. 49 CFR 1542.213 - Training.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Training. 1542.213 Section 1542.213 Transportation..., DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY AIRPORT SECURITY Operations § 1542.213 Training. (a... training in accordance with TSA-approved curriculum specified in the security program. This curriculum...

  14. 28 CFR 21.3 - Aliens.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Aliens. 21.3 Section 21.3 Judicial Administration DEPARTMENT OF JUSTICE WITNESS FEES § 21.3 Aliens. (a) Aliens entitled to payment of $30 per day. The following aliens are entitled to witness fees and allowances provided in § 21.4: (1)...

  15. 29 CFR 780.213 - Produce business.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Produce business. 780.213 Section 780.213 Labor Regulations... Specific Situations Hatchery Operations § 780.213 Produce business. In some instances, hatcheries also engage in the produce business as such and commingle with the culled eggs and chickens other eggs...

  16. 15 CFR 904.213 - Settlements.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Settlements. 904.213 Section 904.213 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC... and Appeal Procedures General § 904.213 Settlements. If settlement is reached before the Judge...

  17. 47 CFR 76.213 - Lotteries.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Lotteries. 76.213 Section 76.213... CABLE TELEVISION SERVICE Cablecasting § 76.213 Lotteries. (a) No cable television system operator... any lottery, gift, enterprise, or similar scheme, offering prizes dependent in whole or in part...

  18. 42 CFR 93.213 - Institution.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Institution. 93.213 Section 93.213 Public Health... MISCONDUCT Definitions § 93.213 Institution. Institution means any individual or person that applies for or... or other research institutes, small research institutions, and independent researchers....

  19. 49 CFR 213.123 - Tie plates.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Tie plates. 213.123 Section 213.123 Transportation... TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.123 Tie plates. (a) In Classes 3 through 5 track where timber crossties are in use there shall be tie plates under the running rails on at least eight...

  20. 14 CFR 171.213 - Reports.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Reports. 171.213 Section 171.213 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES VHF Marker Beacons § 171.213 Reports. The owner of each...

  1. 14 CFR 21.213 - Eligibility.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Eligibility. 21.213 Section 21.213 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION... manufacturer who is a United States citizen may apply for a Class I or Class II provisional...

  2. 31 CFR 31.213 - General standards.

    Science.gov (United States)

    2010-07-01

    ... to the Treasury that is relating to services under EESA or required pursuant to 31 CFR Part 31 is... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false General standards. 31.213 Section 31... Conflicts of Interest § 31.213 General standards. (a) During the time period in which a retained entity...

  3. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  4. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Science.gov (United States)

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  5. 45 CFR 213.25 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... STATES ON CONFORMITY OF PUBLIC ASSISTANCE PLANS TO FEDERAL REQUIREMENTS Hearing Procedures § 213.25... opportunity shall be given to refute facts and arguments advanced on either side of the issues....

  6. 7 CFR 1400.213 - Military personnel.

    Science.gov (United States)

    2010-01-01

    ... OF AGRICULTURE GENERAL REGULATIONS AND POLICIES PAYMENT LIMITATION AND PAYMENT ELIGIBILITY FOR 2009 AND SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS Payment Eligibility § 1400.213 Military personnel. If a... determination will remain in effect for the program year....

  7. Dicty_cDB: SSA213 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA213 (Link to dictyBase) - - - Contig-U16397-1 SSA213Z (Link... to Original site) - - SSA213Z 537 - - - - Show SSA213 Library SS (Link to library) Clone ID SSA213 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA2-A/SSA213Q.Seq.d/ Representative seq. ID SSA21...3Z (Link to Original site) Representative DNA sequence >SSA213 (SSA213Q) /CSM/SS/SSA2-A/SSA213Q.Seq.d/ XXXXX...lkk*k*k**flivk k Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSA

  8. 49 CFR 571.213 - Standard No. 213; Child restraint systems.

    Science.gov (United States)

    2010-10-01

    ... Motor Vehicle Safety Standards § 571.213 Standard No. 213; Child restraint systems. S1. Scope. This... vehicle crashes and in aircraft. S3. Application. This standard applies to passenger cars, multipurpose.... S4. Definitions. Add-on child restraint system means any portable child restraint system....

  9. 47 CFR 213.6 - Criteria.

    Science.gov (United States)

    2010-10-01

    ... CORRESPONDENCE TELECOMMUNICATIONS PRECEDENCE SYSTEM § 213.6 Criteria. (a) Flash, Flash Emergency. (1) This is the...) Flash, or Flash Emergency telephone calls or messages shall be handled in the order received and ahead... necessary to obtain a circuit for a Flash, or Flash Emergency call any call in progress of a...

  10. Evaluation of decay data of 213Bi

    Institute of Scientific and Technical Information of China (English)

    HUANG Xiaolong; WANG Baosong

    2007-01-01

    213Bi disintegrates (97.91±0.03) % by β- emission to the levels in 213po, and (2.09±0.03) % through α decay to 209Tl. The evaluation of the complete decay scheme and data of 213Bi including the recent new measurements are presented in this report. The Limitation of Relative Statistical Weight Method (LWM) was applied to average numbers throughout the evaluation. The uncertainty assigned to the average value was always greater than or equal to the smallest uncertainty of the values used to calculate the average. The half-life is determined to be 45.59±0.06 minutes. All known measured gamma-ray relative emission probabilities have been examined. And the gamma-ray emission probability of the reference γ line of 440.44keV is recommended to be (26.1±0.3) %. The calculated internal conversion coefficients and their uncertainties have been used to obtain the complete decay intensity balance. The other decay characteristics are calculated using the ENSDF analysis program. Finally the new 213Bi decay scheme was re-built.

  11. 27 CFR 9.213 - Snipes Mountain.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Snipes Mountain. 9.213... Snipes Mountain. (a) Name. The name of the viticultural area described in this section is “Snipes Mountain”. For purposes of part 4 of this chapter, “Snipes Mountain” is a term of viticultural...

  12. 32 CFR 552.213 - Policy.

    Science.gov (United States)

    2010-07-01

    ... Installation of Aberdeen Proving Ground, Maryland § 552.213 Policy. (a) Aberdeen Proving Ground is a non-public forum and is open for expensive activity only under certain circumstances. Aberdeen Proving Ground is a..., and other official business. (b) On Aberdeen Proving Ground, except for activities......

  13. 7 CFR 1280.213 - Investment of funds.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Investment of funds. 1280.213 Section 1280.213... INFORMATION ORDER Lamb Promotion, Research, and Information Order Expenses § 1280.213 Investment of funds. The... the United States. Income from any such investment may be used for any purpose for which the...

  14. 22 CFR 213.29 - Suspension-general.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Suspension-general. 213.29 Section 213.29 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT CLAIMS COLLECTION Suspension or Termination of Collection Action § 213.29 Suspension—general. The CFO may suspend or terminate the Agency's...

  15. 14 CFR 1274.213 - Distribution of cooperative agreements.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Distribution of cooperative agreements. 1274.213 Section 1274.213 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS WITH COMMERCIAL FIRMS Pre-Award Requirements § 1274.213 Distribution of...

  16. 22 CFR 213.11 - Aggressive collection actions; documentation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Aggressive collection actions; documentation. 213.11 Section 213.11 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT CLAIMS COLLECTION Collection § 213.11 Aggressive collection actions; documentation. (a) USAID takes actions and...

  17. 29 CFR 2.13 - Audiovisual coverage prohibited.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Audiovisual coverage prohibited. 2.13 Section 2.13 Labor Office of the Secretary of Labor GENERAL REGULATIONS Audiovisual Coverage of Administrative Hearings § 2.13 Audiovisual coverage prohibited. The Department shall not permit audiovisual coverage of...

  18. 5 CFR 213.3102 - Entire executive civil service.

    Science.gov (United States)

    2010-01-01

    ...) Editorial Note: For Federal Register citations affecting § 213.3102, see the List of CFR Sections Affected... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Entire executive civil service. 213.3102 Section 213.3102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE...

  19. 49 CFR 229.213 - Locomotive manufacturing information.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Locomotive manufacturing information. 229.213 Section 229.213 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Design Requirements § 229.213 Locomotive manufacturing information. (a) Each railroad operating...

  20. 47 CFR 36.213 - Network access services revenues.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Network access services revenues. 36.213 Section 36.213 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES... Income Accounts Operating Revenues § 36.213 Network access services revenues. (a) End User...

  1. New method for large scale production of medically applicable Actinium-225 and Radium-223

    International Nuclear Information System (INIS)

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  2. 49 CFR 213.9 - Classes of track: operating speed limits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Classes of track: operating speed limits. 213.9... speed limits. (a) Except as provided in paragraph (b) of this section and §§ 213.57(b), 213.59(a), 213.113(a), and 213.137(b) and (c), the following maximum allowable operating speeds apply— Over...

  3. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    International Nuclear Information System (INIS)

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  4. 26 CFR 1.213-1 - Medical, dental, etc., expenses.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Medical, dental, etc., expenses. 1.213-1 Section... (CONTINUED) INCOME TAXES Additional Itemized Deductions for Individuals § 1.213-1 Medical, dental, etc... treatments affecting any portion of the body, including obstetrical expenses and expenses of therapy or...

  5. 14 CFR 135.213 - Weather reports and forecasts.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Weather reports and forecasts. 135.213... Operating Limitations and Weather Requirements § 135.213 Weather reports and forecasts. (a) Whenever a person operating an aircraft under this part is required to use a weather report or forecast, that...

  6. 14 CFR 213.2 - Reports of traffic data.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Reports of traffic data. 213.2 Section 213... traffic data. The Department may at any time require any foreign air carrier to file with the Department traffic data disclosing the nature and extent of such carrier's engagement in transportation...

  7. 14 CFR 91.213 - Inoperative instruments and equipment.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Inoperative instruments and equipment. 91.213 Section 91.213 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... authorization constitute a supplemental type certificate for the aircraft. (3) The approved Minimum...

  8. 25 CFR 213.33 - Diligence and prevention of waste.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Diligence and prevention of waste. 213.33 Section 213.33... prevention of waste. The lessee shall exercise diligence in drilling and operating wells for oil and gas on... prevention of waste of oil or gas developed on the land, or the entrance of water through wells drilled...

  9. 45 CFR 213.5 - Filing and service of papers.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Filing and service of papers. 213.5 Section 213.5... and service of papers. (a) All papers in the proceedings shall be filed with the FSA Hearing Clerk, in...) All papers in the proceedings shall be served on all parties by personal delivery or by mail....

  10. 40 CFR 262.213 - Laboratory clean-outs.

    Science.gov (United States)

    2010-07-01

    ... product (listed in 40 CFR part 261, subpart D or exhibiting one or more characteristics in 40 CFR part 261... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Laboratory clean-outs. 262.213 Section....213 Laboratory clean-outs. (a) One time per 12 month period for each laboratory, an eligible...

  11. 29 CFR 1952.213 - Compliance staffing benchmarks.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Compliance staffing benchmarks. 1952.213 Section 1952.213... Compliance staffing benchmarks. Under the terms of the 1978 Court Order in AFL-CIO v. Marshall compliance staffing levels (benchmarks) necessary for a “fully effective” enforcement program were required to...

  12. 29 CFR 1910.213 - Woodworking machinery requirements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Woodworking machinery requirements. 1910.213 Section 1910..., DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Machinery and Machine Guarding § 1910.213 Woodworking machinery requirements. (a) Machine construction general. (1) Each machine shall be so...

  13. Radioimmunotherapy of micrometastases in lung with vascular targeted213Bi

    OpenAIRE

    Kennel, S. J.; Boll, R.; Stabin, M; Schuller, H M; Mirzadeh, S

    1999-01-01

    A model system has been used to test the efficacy of vascular targeting of α-particle emitter213Bi for therapy of small, ‘artificial’ metastases in mouse lung. Specific monoclonal antibody (mAb) 201B was used to deliver greater than 30% of the injected dose to lung where tumours had developed due to intravenous injection of cells. Specific213Bi-mAb 201B treatment of BALB/c mammary carcinoma EMT-6 tumours in lung resulted in a dose-dependent destruction of tumours and an extended lifespan of t...

  14. Xinjiang:Cotton Yield Down 21.3%

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Under the impact of policy adjustment and market recession, the larg-est cotton region Xinjiang reported coverage of 20.156 million mu, down 19.4%. The yeild is estimated to be 2.3746 million tons, down 21.3%

  15. VERITAS and VLBA Observations of HESS J1943+213

    CERN Document Server

    Shahinyan, Karlen

    2016-01-01

    HESS J1943+213 is a very high energy (VHE; 100 GeV) {\\gamma}-ray source in the direction of the Galactic plane. 38 hours of deep VERITAS observations taken over two seasons detect the source with ~20 {\\sigma} significance. Monitoring observations of HESS J1943+213 show a remarkably stable flux and spectrum in VHE {\\gamma}-rays. Studies exploring the classification of HESS J1943+213 are converging towards accepting the source as an extreme synchrotron BL Lac object. Specifically, overall SED characteristics of the source, the detection of a potential host galaxy in near-IR imaging, and VLBI observations of the HESS J1943+213 radio counterpart showing extended jet-like emission at milliarcsecond scale and core flux density variability establish the source as a blazar. Recent Very Long Baseline Array (VLBA) observations of the source (shown here for the first time) confirm the extended structure found in the 1.6 GHz band and detect the jet-like component in the 4.6 GHz and the 7.3 GHz bands. The spectral indices...

  16. 9 CFR 113.213 - Pseudorabies Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Pseudorabies Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.213 Pseudorabies Vaccine, Killed Virus. Pseudorabies Vaccine,...

  17. 25 CFR 213.43 - Relinquishment of Government supervision.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Relinquishment of Government supervision. 213.43 Section... Relinquishment of Government supervision. All oil and gas leases hereafter executed shall contain the following relinquishment of supervision clause and terms operative after such relinquishment, or other provisions...

  18. 40 CFR 98.213 - Calculating GHG emissions.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Miscellaneous Uses of Carbonate § 98.213 Calculating GHG emissions. You must determine CO2 process emissions from carbonate use in accordance with the procedures... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Calculating GHG emissions....

  19. 23 CFR 645.213 - Use and occupancy agreements (permits).

    Science.gov (United States)

    2010-04-01

    ... OPERATIONS UTILITIES Accommodation of Utilities § 645.213 Use and occupancy agreements (permits). The written... will not be applicable to each individual utility installation, the use and occupancy agreement must..., maintenance, access restriction, and any special conditions applicable to each installation. (b) A...

  20. 42 CFR 57.213a - Loan cancellation reimbursement.

    Science.gov (United States)

    2010-10-01

    ... CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS Health Professions Student Loans § 57.213a Loan cancellation reimbursement. (a) For loans made prior to October 22... Secretary at the time of distribution of the assets of the school's Fund under section 728 of the Act....

  1. 41 CFR 101-29.213 - Commercial product.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Commercial product. 101... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 29-FEDERAL PRODUCT DESCRIPTIONS 29.2-Definitions § 101-29.213 Commercial product. A commercial product is any item, component,...

  2. 27 CFR 24.213 - Heavy bodied blending wine.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Heavy bodied blending wine..., DEPARTMENT OF THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.213 Heavy bodied blending wine. Heavy bodied blending wine is wine made for blending purposes from grapes or other fruit...

  3. 8 CFR 213a.2 - Use of affidavit of support.

    Science.gov (United States)

    2010-01-01

    ... section 203(b) of the Act, if a relative (as defined in 8 CFR 213a.1) of the intending immigrant is a... an alien who is accompanying, as defined in 22 CFR 40.1, a principal intending immigrant must submit... intending immigrant must include with his or her application for an immigrant visa or adjustment of status...

  4. 24 CFR 213.258 - Subsequent annual premiums.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Subsequent annual premiums. 213.258... premiums. (a) Until the mortgage is paid in full or until receipt by the Commissioner of an application for... annual mortgage insurance premium equal to one-half of one percent of the average outstanding...

  5. The synthesis of [2-13C]2-nitropropane at room temperature and at atmospheric pressure

    OpenAIRE

    Jacquemijns M; Zomer G

    1990-01-01

    In this report the synthesis of [2-13C]2-nitropropane at room temperature is described. [2-13C]Acetone was converted into the oxime with hydroxy hydrochloridelamine and sodium carbonate. Treatment with hypobromic acid resulted in 2-13C]2-bromo-2-nitropropane. Hydrogenation with sodium borohydride gave [2-13C]2-nitropropane in 14,3% overall yield.

  6. 20 CFR 725.213 - Duration of entitlement; surviving spouse or surviving divorced spouse.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Duration of entitlement; surviving spouse or surviving divorced spouse. 725.213 Section 725.213 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION... Benefits) § 725.213 Duration of entitlement; surviving spouse or surviving divorced spouse. (a)...

  7. The synthesis of [2-13C]2-nitropropane at room temperature and at atmospheric pressure

    NARCIS (Netherlands)

    Jacquemijns M; Zomer G

    1990-01-01

    In this report the synthesis of [2-13C]2-nitropropane at room temperature is described. [2-13C]Acetone was converted into the oxime with hydroxy hydrochloridelamine and sodium carbonate. Treatment with hypobromic acid resulted in 2-13C]2-bromo-2-nitropropane. Hydrogenation with sodium borohydride

  8. 49 CFR 213.347 - Automotive or railroad crossings at grade.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Automotive or railroad crossings at grade. 213.347 Section 213.347 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Higher § 213.347 Automotive or railroad crossings at grade. (a) There shall be no at-grade...

  9. Calibration of a NE213 detector for neutron spectroscopy

    International Nuclear Information System (INIS)

    This work describes the experimental way followed for getting the calibration of a NE213 detector with a beam of neutrons from the J.E.N. 2 MeV Van de Graaff and using at once pulse shape discrimination. Detector has been used for measuring the spectrum of the fast reactor CORAL-1. There is also included an experimental method in order to get with precision where the Compton edge is placed on the electron spectrum. (Author) 9 refs

  10. Effect of Fluorination of 2,1,3-Benzothiadiazole

    OpenAIRE

    Nielsen, Christian B.; White, Andrew J P; McCulloch, Iain

    2015-01-01

    The 4,7-dithieno-2,1,3-benzothiadiazole (DTBT) moiety and its fluorinated counterpart are important π-conjugated building blocks in the field of organic electronics. Here we present a combined experimental and theoretical investigation into fundamental properties relating to these two molecular entities and discuss the potential impact on extended π-conjugated materials and their electronic properties. While the fluorinated derivative, in the solid state, packs with a cofacial overlap smaller...

  11. Calibration of a NE213 detector for neutron spectroscopy; Calibracion de un detector de NE213 para espectroscopia de neutrones

    Energy Technology Data Exchange (ETDEWEB)

    Blazquez Martinez, J.; Butragueno Casado, J. L.

    1974-07-01

    This work describes the experimental way followed for getting the calibration of a NE213 detector with a beam of neutrons from the J.E.N. 2 MeV Van de Graaff and using at once pulse shape discrimination. Detector has been used for measuring the spectrum of the fast reactor CORAL-1. There is also included an experimental method in order to get with precision where the Compton edge is placed on the electron spectrum. (Author) 9 refs.

  12. n-γ discrimination of NE213 scintillator%NE213闪烁体的n-γ分辨

    Institute of Scientific and Technical Information of China (English)

    叶邦角; NanjyoH; KobayashiT; TsunoS; HasukoK

    2003-01-01

    NE213闪烁体广泛使用于探测快中子,但却伴随很高的γ本底.本文使用快信号门与总信号门的两门积分方法,用快信号与总信号进行二维作图来分辨粒子.用252Cf 中子源和d+D核反应产生的单能中子研究了φ5"×2"、φ5"×5"和φ8"×2"三种尺寸的NE213闪烁体的n-γ分辨性能,通过选择合适的门宽,获得了极好的n-γ分辨效果.对φ5"×2"的NE213,最佳快信号门宽为30ns.

  13. Preparation of a 1 mg/cm213C target

    International Nuclear Information System (INIS)

    We give a description for the production of 13C foils and the preparation of an approximately 1 mg/cm2 thick target. A recent experiment to measure the mass of 36Ca via the 40Ca(4He,8He)36Ca reaction at the S800 magnetic spectrometer at MSU, needed a precise determination of the beam energy and calibration of the focal plane of the magnetic spectrometer in order to achieve the most accurate value for the 36Ca mass. The 1 mg/cm213C target was essential for these purposes. Target performance along with some preliminary results will also be discussed

  14. 49 CFR 213.143 - Frog guard rails and guard faces; gage.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Frog guard rails and guard faces; gage. 213.143... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.143 Frog guard rails and guard faces; gage. The guard check and guard face gages in frogs shall be within the...

  15. 49 CFR 213.355 - Frog guard rails and guard faces; gage.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Frog guard rails and guard faces; gage. 213.355... Higher § 213.355 Frog guard rails and guard faces; gage. The guard check and guard face gages in frogs... distance between the gage line of a frog to the guard line 1 of its guard rail or guarding face,...

  16. 24 CFR 213.275 - Nature of the Cooperative Management Housing Insurance Fund.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Nature of the Cooperative Management Housing Insurance Fund. 213.275 Section 213.275 Housing and Urban Development Regulations Relating... Nature of the Cooperative Management Housing Insurance Fund. The Cooperative Management Housing...

  17. 5 CFR 213.3301 - Positions of a confidential or policy-determining nature.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Positions of a confidential or policy-determining nature. 213.3301 Section 213.3301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... or policy-determining nature. (a) Upon specific authorization by OPM, agencies may make...

  18. 48 CFR 253.213-70 - Completion of DD Form 1155, Order for Supplies or Services.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Completion of DD Form 1155... Forms 253.213-70 Completion of DD Form 1155, Order for Supplies or Services. Follow the procedures at PGI 253.213-70 for completion of DD Form 1155....

  19. 31 CFR 585.213 - Exemption of activities related to certain international organizations.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Exemption of activities related to certain international organizations. 585.213 Section 585.213 Money and Finance: Treasury Regulations... related to certain international organizations. Any activities related to the United Nations...

  20. 13 CFR 120.213 - What fixed interest rates may a Lender charge?

    Science.gov (United States)

    2010-01-01

    ... Lender charge? 120.213 Section 120.213 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... have a reasonable fixed interest rate. SBA periodically publishes the maximum allowable rate in the... government determines the interest rate on direct loans. SBA publishes the rate periodically in the...

  1. Pulse-shape discrimination in NE213 liquid scintillator detectors

    Energy Technology Data Exchange (ETDEWEB)

    Cavallaro, M., E-mail: manuela.cavallaro@lns.infn.it [INFN-Laboratori Nazionali del Sud, Catania (Italy); CSFNSM, Catania (Italy); Tropea, S. [INFN-Laboratori Nazionali del Sud, Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Catania (Italy); Agodi, C. [INFN-Laboratori Nazionali del Sud, Catania (Italy); Assié, M.; Azaiez, F. [Institut de Physique Nucléaire, Université Paris-Sud-11-CNRS/IN2P3, 91406 Orsay (France); Boiano, C. [INFN - Sezione di Milano, Milano (Italy); Bondì, M.; Cappuzzello, F.; Carbone, D. [INFN-Laboratori Nazionali del Sud, Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Catania (Italy); De Napoli, M. [INFN - Sezione di Catania, Catania (Italy); Séréville, N. de [Institut de Physique Nucléaire, Université Paris-Sud-11-CNRS/IN2P3, 91406 Orsay (France); Foti, A. [Dipartimento di Fisica e Astronomia, Università di Catania, Catania (Italy); INFN - Sezione di Catania, Catania (Italy); Linares, R. [Instituto de Física da Universidade Federal Fluminense, Rio de Janeiro, Niterói, RJ (Brazil); Nicolosi, D. [INFN-Laboratori Nazionali del Sud, Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Catania (Italy); Scarpaci, J.A. [Institut de Physique Nucléaire, Université Paris-Sud-11-CNRS/IN2P3, 91406 Orsay (France)

    2013-02-01

    The 16-channel fast stretcher BaFPro module, originally developed for processing signals of Barium Fluoride scintillators, has been modified to make a high performing analog pulse-shape analysis of signals from the NE213 liquid scintillators of the EDEN neutron detector array. The module produces two Gaussian signals, whose amplitudes are proportional to the height of the fast component of the output light and to the total energy deposited into the scintillator, respectively. An in-beam test has been performed at INFN-LNS (Italy) demonstrating a low detection threshold, a good pulse-shape discrimination even at low energies and a wide dynamic range for the measurement of the neutrons energy.

  2. 2-(1,3-Benzoxazol-2-yl-1-phenylethenyl benzoate

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Ghorbani

    2011-10-01

    Full Text Available In the title molecule, C22H15NO3, the configuration about the ethylenic double bond is Z configuration and it is approximately coplanar with the adjacent phenyl ring and benzoxazole ring system as indicated by the C(H=C(O—Cphenyl—Cphenyl and Obenzoxazole—C—C(H=C(O torsion angles of 179.88 (15 and 5.7 (2°, respectively. The dihedral angle between the essentially planar (r.m.s. deviation = 0.080 Å 2-(1,3-benzoxazol-2-yl-1-phenylethenyl group and the benzoate phenyl ring is 61.51 (6°. A short intramolecular O...O non-bonded interaction of 2.651 (2 Å is present.

  3. An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation

    International Nuclear Information System (INIS)

    A method for construction and operation of an 225Ac/213Bi generator capable of producing 25-100 mCi of 213Bi suitable for clinical antibody labeling is described. The generator has been designed to have an effective lifetime of several weeks, producing up to six therapeutic doses of radionuclide per day. To date, 57 clinical doses have been prepared and injected into patients using the described 213Bi generator. Factors such as radiation damage, radioprotection, iodide eluate chemistry, radiolabeling chemistry and radionuclidic purity are addressed

  4. Response matrices of NE213 scintillation detectors for neutrons

    International Nuclear Information System (INIS)

    Four NE213 detectors of different size have been calibrated at the accelerator facility of the PTB. The response functions were experimentally determined for 33 neutron energies between 1 MeV and 16 MeV and compared with Monte Carlo simulations using the NRESP7 code. The light output functions for recoil protons were found to be significantly different for all detectors even if they were of the same size. The neutron fluence determined on the basis of the response functions calculated with the corresponding light output functions agreed to better than ±2% with reference values if energy independent adjustment factors between 0.98 and 1.03 were applied. The response matrices required for the unfolding of neutron induced pulse height spectra were therefore calculated with the NRESP7 code taking into account the adjustment factors. Similarly, the response matrices for photons were calculated with the EGS4 code, but without any adjustment. Finally, the DIFBAS code was applied for the unfolding of pure neutron- and photon-induced pulse height spectra. The resulting spectral fluences are in reasonable agreement with the results obtained by time-of-flight measurements and by spectrometry with a Ge detector

  5. Multiple product pathways in photodissociation of nitromethane at 213 nm.

    Science.gov (United States)

    Sumida, Masataka; Kohge, Yasunori; Yamasaki, Katsuyoshi; Kohguchi, Hiroshi

    2016-02-14

    In this paper, we present a photodissociation dynamics study of nitromethane at 213 nm in the π → π(*) transition. Resonantly enhanced multiphoton ionization spectroscopy and ion-imaging were applied to measure the internal state distributions and state-resolved scattering distributions of the CH3, NO(X (2)Π, A (2)Σ(+)), and O((3)PJ) photofragments. The rotationally state-resolved scattering distribution of the CH3 fragment showed two velocity components, of which the slower one decreased the relative intensity as the rotational and vibrational excitations. The translational energy distribution of the faster CH3 fragment indicated the production of the NO2 counter-product in the electronic excited state, wherein 1 (2)B2 was the most probable. The NO(v = 0) fragment exhibited a bimodal translational energy distribution, whereas the NO(v = 1 and 2) fragment exhibited a single translational energy component with a relatively larger internal energy. The translational energy of a portion of the O((3)PJ) photofragment was found to be higher than the one-photon dissociation threshold, indicating the two-photon process involved. The NO(A (2)Σ(+)) fragment, which was detected by ionization spectroscopy via the Rydberg ← A (2)Σ(+) transition, also required two-photon energy. These experimental data corroborate the existence of competing photodissociation product pathways, CH3 + NO2,CH3 + NO + O,CH3O + NO, and CH3NO + O, following the π → π(*) transition. The origins of the observed photofragments are discussed in this report along with recent theoretical studies and previous dynamics experiments performed at 193 nm. PMID:26874485

  6. Multiple product pathways in photodissociation of nitromethane at 213 nm

    Energy Technology Data Exchange (ETDEWEB)

    Sumida, Masataka; Kohge, Yasunori; Yamasaki, Katsuyoshi; Kohguchi, Hiroshi, E-mail: kohguchi@hiroshima-u.ac.jp [Department of Chemistry, Graduate School of Science, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima, Hiroshima 739-8526 (Japan)

    2016-02-14

    In this paper, we present a photodissociation dynamics study of nitromethane at 213 nm in the π → π{sup *} transition. Resonantly enhanced multiphoton ionization spectroscopy and ion-imaging were applied to measure the internal state distributions and state-resolved scattering distributions of the CH{sub 3}, NO(X {sup 2}Π, A {sup 2}Σ{sup +}), and O({sup 3}P{sub J}) photofragments. The rotationally state-resolved scattering distribution of the CH{sub 3} fragment showed two velocity components, of which the slower one decreased the relative intensity as the rotational and vibrational excitations. The translational energy distribution of the faster CH{sub 3} fragment indicated the production of the NO{sub 2} counter-product in the electronic excited state, wherein 1 {sup 2}B{sub 2} was the most probable. The NO(v = 0) fragment exhibited a bimodal translational energy distribution, whereas the NO(v = 1 and 2) fragment exhibited a single translational energy component with a relatively larger internal energy. The translational energy of a portion of the O({sup 3}P{sub J}) photofragment was found to be higher than the one-photon dissociation threshold, indicating the two-photon process involved. The NO(A {sup 2}Σ{sup +}) fragment, which was detected by ionization spectroscopy via the Rydberg ←A {sup 2}Σ{sup +} transition, also required two-photon energy. These experimental data corroborate the existence of competing photodissociation product pathways, CH{sub 3} + NO{sub 2},CH{sub 3} + NO + O,CH{sub 3}O + NO, and CH{sub 3}NO + O, following the π → π{sup *} transition. The origins of the observed photofragments are discussed in this report along with recent theoretical studies and previous dynamics experiments performed at 193 nm.

  7. Long-Term Toxicity of 213Bi-Labelled BSA in Mice.

    Directory of Open Access Journals (Sweden)

    Laëtitia Dorso

    Full Text Available Short-term toxicological evaluations of alpha-radioimmunotherapy have been reported in preclinical assays, particularly using bismuth-213 (213Bi. Toxicity is greatly influenced not only by the pharmacokinetics and binding specificity of the vector but also by non-specific irradiation due to the circulating radiopharmaceutical in the blood. To assess this, an acute and chronic toxicity study was carried out in mice injected with 213Bi-labelled Bovine Serum Albumin (213Bi-BSA as an example of a long-term circulating vector.Biodistribution of 213Bi-BSA and 125I-BSA were compared in order to evaluate 213Bi uptake by healthy organs. The doses to organs for injected 213Bi-BSA were calculated. Groups of nude mice were injected with 3.7, 7.4 and 11.1 MBq of 213Bi-BSA and monitored for 385 days. Plasma parameters, including alanine aminotransferase (ALT, aspartate aminotransferase (AST, blood urea nitrogen (BUN and creatinine, were measured and blood cell counts (white blood cells, platelets and red blood cells were performed. Mouse organs were examined histologically at different time points.Haematological toxicity was transient and non-limiting for all evaluated injected activities. At the highest injected activity (11.1 MBq, mice died from liver and kidney failure (median survival of 189 days. This liver toxicity was identified by an increase in both ALT and AST and by histological examination. Mice injected with 7.4 MBq of 213Bi-BSA (median survival of 324 days had an increase in plasma BUN and creatinine due to impaired kidney function, confirmed by histological examination. Injection of 3.7 MBq of 213Bi-BSA was safe, with no plasma enzyme modifications or histological abnormalities.Haematological toxicity was not limiting in this study. Liver failure was observed at the highest injected activity (11.1 MBq, consistent with liver damage observed in human clinical trials. Intermediate injected activity (7.4 MBq should be used with caution because of

  8. Vasorelaxant effects of novel Kv7.4 channel enhancers ML213 and NS15370

    DEFF Research Database (Denmark)

    Jepps, Thomas Andrew; Bentzen, B H; Stott, J B;

    2014-01-01

    in both rodent and human blood vessels. Recently, two novel Kv7 channel enhancers have been identified, ML213 and NS15370, that show increased potency, particularly on Kv7.4 channels. The aim of this study was to characterise the effects of these novel enhancers in different rat blood vessels and compare...... them to Kv7 enhancers (S-1, BMS-204352, retigabine) described previously. We also sought to determine the binding sites of the new Kv7 enhancers. KEY RESULTS: Both ML213 and NS15370 relaxed segments of rat thoracic aorta, renal artery and mesenteric artery in a concentration-dependent manner....... In the mesenteric artery ML213 and NS15370 displayed EC50 's of 0.74 μM and 0.026 μM, respectively, which were far lower than other Kv7 enhancers tested. Current-clamp experiments revealed both novel enhancers at low concentrations caused significant hyperpolarisation in mesenteric artery smooth muscle cells...

  9. Key elements of the ageing management of the WWER-440/213 type nuclear power plants

    International Nuclear Information System (INIS)

    The owner's intention of WWER-440/213 units in Central Europe is to keep the plants in operation as long as technically feasible and reasonable from business point of view. The preconditions of the long term operation and license renewal are the safety and good plant condition. The past and recent ageing management practices have to ensure the required condition and performance of the essential structures, systems and components. In the paper an overall picture of the long term operation of WWER-440/213 units is given. The review covers ageing of mechanical equipment, building structures and electrical equipment to. Key elements of the ageing management are identified and described. Basic issues of assessment of ageing of essential structures, systems and components, also the issues related to availability of design basis information and lacking environmental qualification are discussed. Reference examples typical for WWER-440/213 plants long term operation are given from Paks Nuclear Power Plant practice. (authors)

  10. Alpha-particle emitting 213Bi-anti-EGFR immunoconjugates eradicate tumor cells independent of oxygenation.

    Directory of Open Access Journals (Sweden)

    Christian Wulbrand

    Full Text Available Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET radiation. High LET α-emitters are thought to eradicate tumor cells independent of cellular oxygenation. Therefore, the aim of this study was to demonstrate that cell-bound α-particle emitting (213Bi immunoconjugates kill hypoxic and normoxic CAL33 tumor cells with identical efficiency. For that purpose CAL33 cells were incubated with (213Bi-anti-EGFR-MAb or irradiated with photons with a nominal energy of 6 MeV both under hypoxic and normoxic conditions. Oxygenation of cells was checked via the hypoxia-associated marker HIF-1α. Survival of cells was analysed using the clonogenic assay. Cell viability was monitored with the WST colorimetric assay. Results were evaluated statistically using a t-test and a Generalized Linear Mixed Model (GLMM. Survival and viability of CAL33 cells decreased both after incubation with increasing (213Bi-anti-EGFR-MAb activity concentrations (9.25 kBq/ml-1.48 MBq/ml and irradiation with increasing doses of photons (0.5-12 Gy. Following photon irradiation survival and viability of normoxic cells were significantly lower than those of hypoxic cells at all doses analysed. In contrast, cell death induced by (213Bi-anti-EGFR-MAb turned out to be independent of cellular oxygenation. These results demonstrate that α-particle emitting (213Bi-immunoconjugates eradicate hypoxic tumor cells as effective as normoxic cells. Therefore, (213Bi-radioimmunotherapy seems to be an appropriate strategy for treatment of hypoxic tumors.

  11. Production of AC-225 and application of the BI-213 daughter in cancer therapy

    Science.gov (United States)

    Koch, L.; Apostolidis, C.; Janssens, W.; Molinet, R.; van Geel, J.

    1999-01-01

    There are several ongoing medical trials to use Bi-213 conjugated to monoclonal antibodies to kill tumour-cells of various cancer types. The institute is supplying Ac-225 generators for the test and is itself engaged in in-vitro cytotoxicity tests. Nuclear reactions leading to Ac-225 are discussed. The present supply of Ac-225 stems from Th-229 decay obtained from aged U-233. From the possible alternative the reactions Ra-226 (p, 2n) Ac-225 is presently favoured. The fabrication of a Ac-225 for Bi-213 generator will be described.

  12. Spectroscopy of high spin states in sup(211,212,213)Fr

    International Nuclear Information System (INIS)

    The level structures of 211Fr, 212Fr and 213Fr have been observed to high spins, approx. 28(h/2π) (and excitation energies approx. 8 MeV) using a variety of gamma-ray spectroscopic techniques. The structure of these nuclides is discussed in terms of couplings of single particle states through empirical shell model calculations. Good agreement with experiment is obtained. In 212Fr and 213Fr core-excited configurations are required to explain the properties of the highest states. A number of long lived states were observed in each nucleus some of which decay by by enhanced E3 transitions. The E3 transition strengths are discussed

  13. Experimental Studies for the VVER-440/213 Bubble Condenser System for Kola NPP at the Integral Test Facility BC V-213

    Directory of Open Access Journals (Sweden)

    Vladimir N. Blinkov

    2012-01-01

    Full Text Available In the frame of Tacis Project R2.01/99, which was running from 2003 to 2005, the bubble condenser system of Kola NPP (unit 3 was qualified at the integral test facility BC V-213. Three LB LOCA tests, two MSLB tests, and one SB LOCA test were performed. The appropriate test scenarios for BC V-213 test facility, modeling accidents in the Kola NPP unit 3, were determined with pretest calculations. Analysis of test results has shown that calculated initial conditions and test scenarios were properly reproduced in the tests. The detailed posttest analysis of the tests performed at BC V-213 test facility was aimed to validate the COCOSYS code for the calculation of thermohydraulic processes in the hermetic compartments and bubble condenser. After that the validated COCOSYS code was applied to NPP calculations for Kola NPP (unit 3. Results of Tacis R2.01/99 Project confirmed the bubble condenser functionality during large and small break LOCAs and MSLB accidents. Maximum loads were reached in the LB LOCA case. No condensation oscillations were observed.

  14. 20 CFR 404.213 - Computation where you are eligible for a pension based on your noncovered employment.

    Science.gov (United States)

    2010-04-01

    ... pension based on your noncovered employment. 404.213 Section 404.213 Employees' Benefits SOCIAL SECURITY... you are eligible for a pension based on your noncovered employment. (a) When applicable. Except as... entitled to a monthly pension(s) for which you first became eligible after 1985 based in whole or part...

  15. 24 CFR 213.259a - Premiums-mortgages insured pursuant to section 238(c) of the Act.

    Science.gov (United States)

    2010-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES COOPERATIVE HOUSING MORTGAGE INSURANCE Contract Rights.... All of the provisions of §§ 213.253 through 213.259 governing mortgage insurance premiums shall...

  16. 27 CFR 25.213 - Beer returned to brewery other than that from which removed.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Beer returned to brewery... AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Beer Returned to Brewery § 25.213 Beer returned to brewery other than that from which removed. (a) Refund or adjustment of...

  17. 14 CFR 145.213 - Inspection of maintenance, preventive maintenance, or alterations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Inspection of maintenance, preventive... Rules § 145.213 Inspection of maintenance, preventive maintenance, or alterations. (a) A certificated repair station must inspect each article upon which it has performed maintenance, preventive...

  18. 22 CFR 213.16 - Use and disclosure of mailing addresses.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Use and disclosure of mailing addresses. 213.16....16 Use and disclosure of mailing addresses. (a) When attempting to locate a debtor in order to... Revenue Service. (b) Addresses obtained from the Internal Revenue Service will be used by the Agency,...

  19. 25 CFR 213.34 - Inspection of premises; books and accounts.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises; books and accounts. 213.34... premises; books and accounts. Lessees shall agree to allow the lessors and their agents or any authorized... books and records, showing manner of operations and persons interested, shall be open at all times...

  20. Direct measurements of secondary water inventory of steam generator PGV-213 in operation

    Energy Technology Data Exchange (ETDEWEB)

    Tarankov, G.A.; Trunov, N.B.; Dranchenko, B.N.; Kamiagin, W.W. [OKB Gidropress (Russian Federation)

    1997-12-31

    Results of weight measurement of PGV-213 steam generator during filling in, heating-up and power increase are described. Special measurement system based on stress gauges has been developed. Method of derivation of secondary water inventory is described. Comparison of the data for two steam generators prove accuracy of the measurements. (orig.). 1 refs.

  1. 48 CFR 213.306 - SF 44, Purchase Order-Invoice-Voucher.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false SF 44, Purchase Order... PROCEDURES Simplified Acquisition Methods 213.306 SF 44, Purchase Order-Invoice-Voucher. (a)(1) The micro...) card may be used instead of an SF 44 for aviation fuel and oil (see http://www.desc.dla.mil);...

  2. 12 CFR Supplement I to Part 213 - Official Staff Commentary to Regulation M

    Science.gov (United States)

    2010-01-01

    ... a fee for the service, refers a customer to a leasing company that will prepare all relevant... interpretations of Regulation M (12 CFR part 213). Good faith compliance with this commentary affords protection... prospective customers the availability of consumer leases, whether in visual, oral, print or electronic...

  3. 25 CFR 700.213 - Methods of providing last resort replacement housing.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Methods of providing last resort replacement housing. 700... RELOCATION PROCEDURES Last Resort Replacement Housing § 700.213 Methods of providing last resort replacement housing. (a) General. The methods of providing last resort housing include, but are not limited to—...

  4. 16 CFR 1500.213 - Presentation of views under section 7 of the act.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Presentation of views under section 7 of the... REGULATIONS § 1500.213 Presentation of views under section 7 of the act. (a) Presentation of views under..., such guaranty or undertaking, or a verified copy thereof, shall be made a part of such presentation...

  5. 48 CFR 1352.213-70 - Evaluation utilizing simplified acquisition procedures.

    Science.gov (United States)

    2010-10-01

    ... Clauses 1352.213-70 Evaluation utilizing simplified acquisition procedures. As prescribed in 48 CFR 1313.106-2-70, insert the following provision: Evaluation Utilizing Simplified Acquisition Procedures (APR... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Evaluation...

  6. 48 CFR 52.213-4 - Terms and Conditions-Simplified Acquisitions (Other Than Commercial Items)

    Science.gov (United States)

    2010-10-01

    ... information.) (xii) 52.247-64, Preference for Privately Owned U.S.-Flag Commercial Vessels (FEB 2006) (46 U.S... provide for the provision, the service, or the sale of food in the United States.) (iv) 52.247-29, F.o.b... Federal Register citations affecting 52.213-4, see the List of CFR Sections Affected, which appears in...

  7. 48 CFR 1852.213-71 - Evaluation-Other Than Commercial Items.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Evaluation-Other Than... Provisions and Clauses 1852.213-71 Evaluation—Other Than Commercial Items. As prescribed in 1813.302-570(b) insert the following provision: Evaluation—Other Than Commercial Items—Jun 2002 (a) The Government...

  8. 22 CFR 213.34 - Debts that have been discharged in bankruptcy.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Debts that have been discharged in bankruptcy... Suspension or Termination of Collection Action § 213.34 Debts that have been discharged in bankruptcy. USAID... General Counsel's office if he believes that any claims or offsets may have survived the discharge of...

  9. {sup 177}Lu-immunotherapy of experimental peritoneal carcinomatosis shows comparable effectiveness to {sup 213}Bi-immunotherapy, but causes toxicity not observed with {sup 213}Bi

    Energy Technology Data Exchange (ETDEWEB)

    Seidl, Christof; Zoeckler, Christine; Beck, Roswitha; Senekowitsch-Schmidtke, Reingard [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Quintanilla-Martinez, Leticia [Universitaetsklinikum Tuebingen, Institute for Pathology, Tuebingen (Germany); Bruchertseifer, Frank [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany)

    2011-02-15

    {sup 213}Bi-d9MAb-immunoconjugates targeting gastric cancer cells have effectively cured peritoneal carcinomatosis in a nude mouse model following intraperitoneal injection. Because the {beta}-emitter {sup 177}Lu has proven to be beneficial in targeted therapy, {sup 177}Lu-d9MAb was investigated in this study in order to compare its therapeutic efficacy and toxicity with those of {sup 213}Bi-d9MAb. Nude mice were inoculated intraperitoneally with HSC45-M2 gastric cancer cells expressing d9-E-cadherin and were treated intraperitoneally 1 or 8 days later with different activities of specific {sup 177}Lu-d9MAb immunoconjugates targeting d9-E-cadherin or with nonspecific {sup 177}Lu-d8MAb. Therapeutic efficacy was evaluated by monitoring survival for up to 250 days. For evaluation of toxicity, both biodistribution of {sup 177}Lu-d9MAb and blood cell counts were determined at different time points and organs were examined histopathologically. Treatment with {sup 177}Lu-immunoconjugates (1.85, 7.4, 14.8 MBq) significantly prolonged survival. As expected, treatment on day 1 after tumour cell inoculation was more effective than treatment on day 8, and specific {sup 177}Lu-d9MAb conjugates were superior to nonspecific {sup 177}Lu-d8MAb. Treatment with 7.4 MBq of {sup 177}Lu-d9MAb was most successful, with 90% of the animals surviving longer than 250 days. However, treatment with therapeutically effective activities of {sup 177}Lu-d9MAb was not free of toxic side effects. In some animals lymphoblastic lymphoma, proliferative glomerulonephritis and hepatocarcinoma were seen but were not observed after treatment with {sup 213}Bi-d9MAb at comparable therapeutic efficacy. The therapeutic efficacy of {sup 177}Lu-d9MAb conjugates in peritoneal carcinomatosis is impaired by toxic side effects. Because previous therapy with {sup 213}Bi-d9MAb revealed comparable therapeutic efficacy without toxicity it should be preferred for the treatment of peritoneal carcinomatosis. (orig.)

  10. Radioimmunotherapy of fungal infection with 213-Bi- and 188-Re-labeled antibody

    International Nuclear Information System (INIS)

    Aim: Radioimmunotherapy (RIT) is a therapeutic modality that utilizes monoclonal antibodies (mAb) radiolabeled with therapeutic radioisotopes to selectively deliver lethal doses of radiation to cells. We hypothesized that 18B7 mAb (murine IgG1), specific for Cryptoccocus neoformans (CN) polysaccharide capsule, may be used to deliver fungicidal doses of radioisotopes to the sites of CN infection in vitro and in vivo. Materials and Methods: 18B7 mAb was radiolabeled with either the beta-emitter 188-Rhenium (188Re) or with the alpha-emitter 213-Bismuth (213Bi). The biodistribution of radiolabeled 18B7 was measured in BALB/c mice with and without intratracheal CN infection. For in vitro killing assays 105 CN cells/well were treated with 0-3.2 μCi 213Bi-18B7 (3 h incubation), 32 μCi 188Re-18B7 (48 h incubation) or with radiolabeled IgG1 MOPC21 as a control and minimal inhibitory concentrations (MIC) were determined. To compare the activity of radiolabeled mAb's against CN infection with an established antifungal drug, we evaluated the susceptibility of CN strain to Amphoterecin B. In vivo therapy of CN was conducted in groups of 10 A/JCr mice infected intravenously with 105 CN cells 24 h prior to treatment with 50-200 μCi 213Bi- or 188Re-18B7, 213Bi- or 188Re-MOPC21, unlabeled 18B7 or saline. Student's t test for unpaired data was used to analyze in vitro data, and log-rank test - for animal survival data. Results: MAb 18B7 preserved its immunoreactivity post-labeling and delivered 10% ID/g to the lungs of the CN-infected BALB/c mice in 24 h after injection. Two-log reduction in colony forming units (CFU) was achieved in treatment of CN with 213Bi-18B7 and 188Re-18B7, which compared favorably with Amphoterecin B. MIC's were determined to be 0.4 μCi/1.5 mg and 4 μCi/1.25 mg mAb for 213Bi-18B7 and 188Re-18B7, respectively. The fungicidal activity of irrelevant mAb 213Bi-or 188Re-MOPC21 was negligible (P213Bi-18B7 and of 100 μCi 188Re-18B7 significantly (P<0

  11. Groundwater Monitoring Plan for the Reactor Technology Complex Operable Unit 2-13

    Energy Technology Data Exchange (ETDEWEB)

    Richard P. Wells

    2007-03-23

    This Groundwater Monitoring Plan describes the objectives, activities, and assessments that will be performed to support the on-going groundwater monitoring requirements at the Reactor Technology Complex, formerly the Test Reactor Area (TRA). The requirements for groundwater monitoring were stipulated in the Final Record of Decision for Test Reactor Area, Operable Unit 2-13, signed in December 1997. The monitoring requirements were modified by the First Five-Year Review Report for the Test Reactor Area, Operable Unit 2-13, at the Idaho National Engineering and Environmental Laboratory to focus on those contaminants of concern that warrant continued surveillance, including chromium, tritium, strontium-90, and cobalt-60. Based upon recommendations provided in the Annual Groundwater Monitoring Status Report for 2006, the groundwater monitoring frequency was reduced to annually from twice a year.

  12. Determination of the half-life of 213Fr with high precision

    Science.gov (United States)

    Fisichella, M.; Musumarra, A.; Farinon, F.; Nociforo, C.; Del Zoppo, A.; Figuera, P.; La Cognata, M.; Pellegriti, M. G.; Scuderi, V.; Torresi, D.; Strano, E.

    2013-07-01

    High-precision measurement of half-life and Qα value of neutral and highly charged α emitters is a major subject of investigation currently. In this framework, we recently pushed half-life measurements of neutral emitters to a precision of a few per mil. This result was achieved by using different techniques and apparatuses at Istituto Nazionale di Fisica Nucleare Laboratori Nazionali del Sud (INFN-LNS) and GSI Darmstadt. Here we report on 213Fr half-life determination [T1/2(213Fr) = 34.14±0.06 s] at INFN-LNS, detailing the measurement protocol used. Direct comparison with the accepted value in the literature shows a discrepancy of more than three sigma. We propose this new value as a reference, discussing previous experiments.

  13. Assessment of computer codes for VVER-440/213-type nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Szabados, L.; Ezsol, Gy.; Perneczky [Atomic Energy Research Institute, Budapest (Hungary)

    1995-09-01

    Nuclear power plant of VVER-440/213 designed by the former USSR have a number of special features. As a consequence of these features the transient behaviour of such a reactor system should be different from the PWR system behaviour. To study the transient behaviour of the Hungarian Paks Nuclear Power Plant of VVER-440/213-type both analytical and experimental activities have been performed. The experimental basis of the research in the PMK-2 integral-type test facility , which is a scaled down model of the plant. Experiments performed on this facility have been used to assess thermal-hydraulic system codes. Four tests were selected for {open_quotes}Standard Problem Exercises{close_quotes} of the International Atomic Energy Agency. Results of the 4th Exercise, of high international interest, are presented in the paper, focusing on the essential findings of the assessment of computer codes.

  14. The 1:1 adduct of caffeine and 2-(1,3-dioxoisoindolin-2-ylacetic acid

    Directory of Open Access Journals (Sweden)

    Moazzam H. Bhatti

    2011-09-01

    Full Text Available In the crystal structure of the title adduct [systematic name: 2-(1,3-dioxoisoindolin-2-ylacetic acid–1,3,7-trimethyl-1,2,3,6-tetrahydro-7H-purine-2,6-dione (1/1], C8H10N4O2·C10H7NO4, the components are linked by an O—H...N hydrogen-bond and no proton transfer occurs.

  15. Digital karyotyping reveals probable target genes at 7q21.3 locus in hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Wang Shengyue

    2011-07-01

    Full Text Available Abstract Background Hepatocellular carcinoma (HCC is a worldwide malignant liver tumor with high incidence in China. Subchromosomal amplifications and deletions accounted for major genomic alterations occurred in HCC. Digital karyotyping was an effective method for analyzing genome-wide chromosomal aberrations at high resolution. Methods A digital karyotyping library of HCC was constructed and 454 Genome Sequencer FLX System (Roche was applied in large scale sequencing of the library. Digital Karyotyping Data Viewer software was used to analyze genomic amplifications and deletions. Genomic amplifications of genes detected by digital karyotyping were examined by real-time quantitative PCR. The mRNA expression level of these genes in tumorous and paired nontumorous tissues was also detected by real-time quantitative RT-PCR. Results A total of 821,252 genomic tags were obtained from the digital karyotyping library of HCC, with 529,162 tags (64% mapped to unique loci of human genome. Multiple subchromosomal amplifications and deletions were detected through analyzing the digital karyotyping data, among which the amplification of 7q21.3 drew our special attention. Validation of genes harbored within amplicons at 7q21.3 locus revealed that genomic amplification of SGCE, PEG10, DYNC1I1 and SLC25A13 occurred in 11 (21%, 11 (21%, 11 (21% and 23 (44% of the 52 HCC samples respectively. Furthermore, the mRNA expression level of SGCE, PEG10 and DYNC1I1 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts. Conclusions Our results indicated that subchromosomal region of 7q21.3 was amplified in HCC, and SGCE, PEG10 and DYNC1I1 were probable protooncogenes located within the 7q21.3 locus.

  16. The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) induces genomic instability by mitotic abnormality

    Energy Technology Data Exchange (ETDEWEB)

    Hitomi, Toshiaki [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Habu, Toshiyuki [Radiation Biology Center, Kyoto University, Kyoto (Japan); Kobayashi, Hatasu; Okuda, Hiroko; Harada, Kouji H. [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Osafune, Kenji [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Taura, Daisuke; Sone, Masakatsu [Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Asaka, Isao; Ameku, Tomonaga; Watanabe, Akira; Kasahara, Tomoko; Sudo, Tomomi; Shiota, Fumihiko [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Hashikata, Hirokuni; Takagi, Yasushi [Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Morito, Daisuke [Faculty of Life Sciences, Kyoto Sangyo University, Kyoto (Japan); Miyamoto, Susumu [Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Nakao, Kazuwa [Department of Medicine and Clinical Science, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Koizumi, Akio, E-mail: koizumi.akio.5v@kyoto-u.ac.jp [Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto (Japan)

    2013-10-04

    Highlights: •Overexpression of RNF213 R4810K inhibited cell proliferation. •Overexpression of RNF213 R4810K had the time of mitosis 4-fold and mitotic failure. •R4810K formed a complex with MAD2 more readily than wild-type. •iPSECs from the MMD patients had elevated mitotic failure compared from the control. •RNF213 R4810K induced mitotic abnormality and increased risk of aneuploidy. -- Abstract: Moyamoya disease (MMD) is a cerebrovascular disease characterized by occlusive lesions in the Circle of Willis. The RNF213 R4810K polymorphism increases susceptibility to MMD. In the present study, we characterized phenotypes caused by overexpression of RNF213 wild type and R4810K variant in the cell cycle to investigate the mechanism of proliferation inhibition. Overexpression of RNF213 R4810K in HeLa cells inhibited cell proliferation and extended the time of mitosis 4-fold. Ablation of spindle checkpoint by depletion of mitotic arrest deficiency 2 (MAD2) did not shorten the time of mitosis. Mitotic morphology in HeLa cells revealed that MAD2 colocalized with RNF213 R4810K. Immunoprecipitation revealed an RNF213/MAD2 complex: R4810K formed a complex with MAD2 more readily than RNF213 wild-type. Desynchronized localization of MAD2 was observed more frequently during mitosis in fibroblasts from patients (n = 3, 61.0 ± 8.2%) compared with wild-type subjects (n = 6, 13.1 ± 7.7%; p < 0.01). Aneuploidy was observed more frequently in fibroblasts (p < 0.01) and induced pluripotent stem cells (iPSCs) (p < 0.03) from patients than from wild-type subjects. Vascular endothelial cells differentiated from iPSCs (iPSECs) of patients and an unaffected carrier had a longer time from prometaphase to metaphase than those from controls (p < 0.05). iPSECs from the patients and unaffected carrier had significantly increased mitotic failure rates compared with controls (p < 0.05). Thus, RNF213 R4810K induced mitotic abnormalities and increased risk of genomic instability.

  17. On the Effect of Fluorination of 2,1,3-Benzothiadiazole

    KAUST Repository

    Nielsen, Christian B.

    2015-04-22

    The 4,7-dithieno-2,1,3-benzothiadiazole (DTBT) moiety and its fluorinated counterpart are important pi-conjugated building blocks in the field of organic electronics. Here we present a combined experimental and theoretical investigation into fundamental properties relating to these two molecular entities and discuss the potential impact on extended π-conjugated materials and their electronic properties. While the fluorinated derivative, in the solid state, packs with a smaller co-facial overlap than DTBT, we report experimental evidence for stronger optical absorption as well as stronger intra- and intermolecular contacts upon fluorination.

  18. On the Use of an ER-213 Detonator to Establish a Baseline for the ER-486

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Keith A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Liechty, Gary H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jaramillo, Dennis C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Munger, Alan C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); McHugh, Douglas C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kennedy, James E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-08-19

    This report documents a series of tests using a TSD-115 fireset coupled with an ER-213, a gold exploding bridgewire (EBW) detonator. These tests were designed to fire this EBW with a smaller fireset to obtain current and voltage data as well as timing information at voltage levels below, above, and throughout the threshold firing region. This study could then create a database for comparison to our current ER-486 EBW development, which is designed to be a lower voltage (<500V) device.

  19. A Case with 46,XX,dup(X(q21.3q24 karyotype

    Directory of Open Access Journals (Sweden)

    Selda Şimşek

    2010-03-01

    Full Text Available The relationship between phenotype and Xq duplicationsin females remains unclear. Some females are normal;some have short stature; and others have features suchas microcephaly, developmental delay/mental retardation,body asymmetries, and gonadal dysgenesis. Somefeatures in these females resemble those in Turner syndrome.We, herein, presented a 15 years-old girl withshort stature and primary amenorrhea, who was referredto cytogenetic laboratory. Through karyotipe analysis performedby Giemsa banding technique, the patient wasdetermined to have positive Barr body and 46,XX,dup(X(q21.3q24 chromosomal constitution. Case was discussedaccording to information of present literatures.

  20. Neutron response matrix for unfolding NE-213 measurements to 21 MeV

    International Nuclear Information System (INIS)

    A neutron response matrix from measured neutron responses of NE-213 in the energy range of 0.2 to 22 MeV is presented. An interpolation scheme was used to construct an 81-column matrix from the data of Verbinski, Burrus, Love, Zobel, and Hill. As a test of the new response matrix, the Cf-252 neutron spectrum was measured and unfolded using the new response matrix and the FORIST unfolding code. The spectrum agrees well with previous measurements at lower energies, while providing new information above 8 MeV

  1. Spectroscopy and octupole coupling of high-spin states in 213Rn

    International Nuclear Information System (INIS)

    Excited states of 213Rn, up to spins of ∼ 55/2 ℎ and an excitation energy of ∼ 6 MeV, have been studied using γ-ray and electron spectroscopy following the reactions 208Pb(9Be,4n) and 204Hg(13C,4n). Eight isomeric states were identified and g-factors for five of these measured by the TDPAD technique. Several of the isomeric states decay by enhanced E3 transitions. The level scheme and electromagnetic properties of the isomers are compared with the results of semi-empirical shell-model calculations including calculations which explicitly account for the particle-octupole vibration coupling

  2. Fission dynamics of the compound nucleus 213Fr formed in heavy-ion-induced reactions

    Indian Academy of Sciences (India)

    Hadi Eslamizadeh

    2013-04-01

    A stochastic approach based on one-dimensional Langevin equations was used to calculate the average pre-fission multiplicities of neutrons, light charged particles and the fission probabilities for the compound nucleus 213Fr and the results are compared with the experimental data. In these calculations, a modified wall and window dissipation with a reduction coefficient, $k_{s}$ , has been used in the Langevin equations. It was shown that the results of the calculations are in good agreement with the experimental data by using values of $k_{s}$ in the range $0.3 ≤ k_{s} ≤ 0.5.$

  3. EVN Observations of HESS J1943+213: Evidence for an Extreme TeV BL Lac Object

    CERN Document Server

    Akiyama, Kazunori; Tanaka, Yasuyuki T; Nagai, Hiroshi; Giroletti, Marcello; Honma, Mareki

    2016-01-01

    We report on the 1.6 GHz (18 cm) VLBI observations of the unresolved, steady TeV source HESS J1943+213 located in the Galactic plane, performed with the European VLBI Network (EVN) in 2014. Our new observations with a nearly full EVN array provide the deepest image of HESS J1943+213 at the highest resolution ever achieved, enabling us to resolve the long-standing issues of the source identification. The milliarcsecond-scale structure of HESS J1943+213 has a clear asymmetric morphology, consisting of a compact core and a diffuse jet-like tail. This is broadly consistent with the previous e-EVN observations of the source performed in 2011, and re-analyzed in this work. The core component is characterized by the brightness temperature of $\\gtrsim1.8 \\times 10^9$ K, which is typical for low-luminosity blazars in general. Overall, radio properties of HESS J1943+213 are consistent with the source classification as an "extreme high-frequency-peaked BL Lac object". Remarkably, we note that since HESS J1943+213 does n...

  4. An investigation on SA 213-Tube to SA 387-Tube plate using friction welding process

    International Nuclear Information System (INIS)

    Friction welding of tube to tube plate using an external tool (FWTPET) is a relatively newer solid state welding process used for joining tube to tube plate of either similar or dissimilar materials with enhanced mechanical and metallurgical properties. In the present study, FWTPET has been used to weld SA 213 (Grade T12) tube with SA 387 (Grade 22) tube plate. The welded samples are found to have satisfactory joint strength and the Energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) study showed that inter metallic compound is absent in the weld zone. The different weld joints have been identified and the phase composition is found using EDX and XRD. Microstructures have been analyzed using optical and Scanning electron microscopy (SEM). The mechanical properties such as hardness, compressive shear strength and peel test for different weld conditions are studied and the hardness survey revealed that there is increase in hardness at the weld interface due to grain refinement. The corrosion behavior for different weld conditions have been analyzed and the weld zone is found to have better corrosion resistance due to the influence of the grain refinement after FWTPET welding process. Hence, the present investigation is carried out to study the behavior of friction welded dissimilar joints of SA 213 tube and SA 387 tube plate joints and the results are presented. The present study confirms that a high quality tube to tube plate joint can be achieved using FWTPET process at 1120 rpm

  5. An investigation on SA 213-Tube to SA 387-Tube plate using friction welding process

    Energy Technology Data Exchange (ETDEWEB)

    Rajan, S. Pandia; Kumaraswamidhas, L. A. [Indian Institute of Technology, Jharkhand (India); Kumaran, S. Senthil [RVS School of Engineering and Technology, Tamil Nadu (India); Muthukumaran, S. [National Institute of Technology, Tamil Nadu (India)

    2016-01-15

    Friction welding of tube to tube plate using an external tool (FWTPET) is a relatively newer solid state welding process used for joining tube to tube plate of either similar or dissimilar materials with enhanced mechanical and metallurgical properties. In the present study, FWTPET has been used to weld SA 213 (Grade T12) tube with SA 387 (Grade 22) tube plate. The welded samples are found to have satisfactory joint strength and the Energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) study showed that inter metallic compound is absent in the weld zone. The different weld joints have been identified and the phase composition is found using EDX and XRD. Microstructures have been analyzed using optical and Scanning electron microscopy (SEM). The mechanical properties such as hardness, compressive shear strength and peel test for different weld conditions are studied and the hardness survey revealed that there is increase in hardness at the weld interface due to grain refinement. The corrosion behavior for different weld conditions have been analyzed and the weld zone is found to have better corrosion resistance due to the influence of the grain refinement after FWTPET welding process. Hence, the present investigation is carried out to study the behavior of friction welded dissimilar joints of SA 213 tube and SA 387 tube plate joints and the results are presented. The present study confirms that a high quality tube to tube plate joint can be achieved using FWTPET process at 1120 rpm.

  6. Chains of dense cores in the Taurus L1495/B213 complex

    CERN Document Server

    Tafalla, M

    2014-01-01

    (Abridged) We study the kinematics of the dense gas in the Taurus L1495/B213 filamentary region to investigate the mechanism of core formation. We use observations of N2H+(1-0) and C18O(2-1) carried out with the IRAM 30m telescope. We find that the dense cores in L1495/B213 are significantly clustered in linear chain-like groups about 0.5pc long. The internal motions in these chains are mostly subsonic and the velocity is continuous, indicating that turbulence dissipation in the cloud has occurred at the scale of the chains and not at the smaller scale of the individual cores. The chains also present an approximately constant abundance of N2H+ and radial intensity profiles that can be modeled with a density law that follows a softened power law. A simple analysis of the spacing between the cores using an isothermal cylinder model indicates that the cores have likely formed by gravitational fragmentation of velocity-coherent filaments. Combining our analysis of the cores with our previous study of the large-sc...

  7. HESS J1943+213: a non-classical high-frequency-peaked BL Lac object

    CERN Document Server

    Straal, Samayra M; van Leeuwen, Joeri; Clarke, Tracy E; Dubner, Gloria; Frey, Sandor; Giacani, Elsa; Paragi, Zsolt

    2016-01-01

    HESS J1943+213 is an unidentified TeV source that is likely a high-frequency-peaked BL Lac (HBL) object but also compatible with a pulsar wind nebula (PWN) nature. Each of these enormously different astronomical interpretations is supported by some of the observed unusual characteristics. In order to finally classify and understand this object we took a three-pronged approach, through time-domain, high angular resolution, and multi-frequency radio studies. First, our deep time-domain observations with the Arecibo telescope failed to uncover the putative pulsar powering the proposed PWN. We conclude with ~70% certainty that HESS J1943+213 does not host a pulsar. Second, long-baseline interferometry of the source with e-MERLIN at 1.5- and 5- GHz, shows only a core, a point source at ~ 1 - 100 milli-arcsecond resolution. Its 2013 flux density is about one-third lower than detected in 2011 observations with similar resolution. This radio variability of the core strengthens the HBL object hypothesis. More evidence...

  8. HESS J1943+213: a candidate extreme BL Lacertae object

    CERN Document Server

    Abramowski, A; Aharonian, F; Akhperjanian, A G; Anton, G; Balzer, A; Barnacka, A; de Almeida, U Barres; Bazer-Bachi, A R; Becherini, Y; Becker, J; Behera, B; Bernlöhr, K; Bochow, A; Boisson, C; Bolmont, J; Bordas, P; Borrel, V; Brucker, J; Brun, F; Brun, P; Bulik, T; Büsching, I; Carrigan, S; Casanova, S; Cerruti, M; Chadwick, P M; Charbonnier, A; Chaves, R C G; Cheesebrough, A; Chounet, L -M; Clapson, A C; Coignet, G; Colom, P; Conrad, J; Dalton, M; Daniel, M K; Davids, I D; Degrange, B; Deil, C; Dickinson, H J; Djannati-Ataï, A; Domainko, W; Drury, L O'C; Dubois, F; Dubus, G; Dyks, J; Dyrda, M; Egberts, K; Eger, P; Espigat, P; Fallon, L; Farnier, C; Fegan, S; Feinstein, F; Fernandes, M V; Fiasson, A; Fontaine, G; Förster, A; Fü\\ssling, M; Gallant, Y A; Gast, H; Gérard, L; Gerbig, D; Giebels, B; Glicenstein, J F; Glück, B; Goret, P; Göring, D; Häffner, S; Hague, J D; Hampf, D; Hauser, M; Heinz, S; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hoffmann, A; Hofmann, W; Hofverberg, P; Holler, M; Horns, D; Jacholkowska, A; de Jager, O C; Jahn, C; Jamrozy, M; Jung, I; Kastendieck, M A; Katarzyński, K; Katz, U; Kaufmann, S; Keogh, D; Khangulyan, D; Khélifi, B; Klochkov, D; Kluźniak, W; Kneiske, T; Komin, Nu; Kosack, K; Kossakowski, R; Laffon, H; Lamanna, G; Lennarz, D; Lohse, T; Lopatin, A; Lu, C -C; Marandon, V; Marcowith, A; Masbou, J; Maurin, D; Maxted, N; McComb, T J L; Medina, M C; Méhault, J; Nguyen, N; Moderski, R; Moulin, E; Naumann, C L; Naumann-Godo, M; de Naurois, M; Nedbal, D; Nekrassov, D; Nicholas, B; Niemiec, J; Nolan, S J; Ohm, S; Olive, J-F; Wilhelmi, E de Oña; Opitz, B; Ostrowski, M; Panter, M; Arribas, M Paz; Pedaletti, G; Pelletier, G; Petrucci, P -O; Pita, S; Pühlhofer, G; Punch, M; Quirrenbach, A; Raue, M; Rayner, S M; Reimer, A; Reimer, O; Renaud, M; Reyes, R de los; Rieger, F; Ripken, J; Rob, L; Rosier-Lees, S; Rowell, G; Rudak, B; Rulten, C B; Ruppel, J; Ryde, F; Sahakian, V; Santangelo, A; Schlickeiser, R; Schöck, F M; Schönwald, A; Schulz, A; Schwanke, U; Schwarzburg, S; Schwemmer, S; Shalchi, A; Sikora, M; Skilton, J L; Sol, H; Spengler, G; Stawarz, \\L; Steenkamp, R; Stegmann, C; Stinzing, F; Stycz, K; Sushch, I; Szostek, A; Tavernet, J -P; Terrier, R; Tibolla, O; Tluczykont, M; Valerius, K; van Eldik, C; Vasileiadis, G; Venter, C; Vialle, J P; Viana, A; Vincent, P; Vivier, M; Völk, H J; Volpe, F; Vorobiov, S; Vorster, M; Wagner, S J; Ward, M; Wierzcholska, A; Zajczyk, A; Zdziarski, A A; Zech, A; Zechlin, H -S; Burnett, T H; Hill, A B

    2011-01-01

    We report on a newly detected point-like source, HESS J1943+213 located in the Galactic plane. This source coincides with an unidentified hard X-ray source IGR J19443+2117, which was proposed to have radio and infrared counterparts. HESS J1943+213 is detected at the significance level of 7.9 \\sigma (post-trials) at RA(J2000)=19h 43m 55s +- 1s (stat) +- 1s (sys), DEC(J2000) = +21deg 18' 8" +- 17" (stat) +- 20" (sys). The source has a soft spectrum with photon index Gamma = 3.1 +- 0.3 (stat) +- 0.2 (sys) and a flux above 470 GeV of 1.3 +- 0.2 (stat) +- 0.3 (sys) x 10^{-12} cm^{-2} s^{-1}. There is no Fermi/LAT counterpart down to a flux limit of 6 x 10^{-9} cm^{-2} s^{-1} in the 0.1-100 GeV energy range (95% confidence upper limit calculated for an assumed power-law model with a photon index Gamma=2.0). The data from radio to VHE gamma-rays do not show any significant variability. We combine new H.E.S.S., Fermi/LAT and Nancay Radio Telescope observations with pre-existing non-simultaneous multi-wavelength obser...

  9. Split Hand/Foot Malformation Associated with 7q21.3 Microdeletion: A Case Report.

    Science.gov (United States)

    Sivasankaran, Aswini; Srikanth, Ambika; Kulshreshtha, Pooja S; Anuradha, Deenadayalu; Kadandale, Jayarama S; Samuel, Chandra R

    2016-02-01

    Split hand/foot malformation (SHFM) or ectrodactyly is a rare genetic condition affecting limb development. SHFM shows clinical and genetic heterogeneity. It can present as an isolated form or in combination with additional anomalies affecting the long bones (nonsyndromic form) or other organ systems including the craniofacial, genitourinary and ectodermal structures (syndromic ectrodactyly). This study reports a girl with SHFM who also exhibited developmental delay, mild dysmorphic facial features and sensorineural hearing loss. High-resolution banding analysis indicated an interstitial deletion within the 7q21 band. FISH using locus-specific BAC probes confirmed the microdeletion of 7q21.3. Chromosomal microarray analysis also revealed a microdeletion of 1.856 Mb in 7q21.3. However, a larger 8.44-Mb deletion involving bands 7q21.11q21.2 was observed, and the breakpoints were refined. The phenotype and the candidate genes underlying the pathogenesis of this disorder are discussed. PMID:27022330

  10. Antibacterial activity and genotypic-phenotypic characteristics of bacteriocin-producing Bacillus subtilis KKU213: potential as a probiotic strain.

    Science.gov (United States)

    Khochamit, Nalisa; Siripornadulsil, Surasak; Sukon, Peerapol; Siripornadulsil, Wilailak

    2015-01-01

    The antimicrobial activity and probiotic properties of Bacillus subtilis strain KKU213, isolated from local soil, were investigated. The cell-free supernatant (CFS) of a KKU213 culture containing crude bacteriocins exhibited inhibitory effects on Gram-positive bacteria, including Bacillus cereus, Listeria monocytogenes, Micrococcus luteus, and Staphylococcus aureus. The antibacterial activity of the CFS precipitated with 40% ammonium sulfate (AS) remained even after treatment at 60 and 100 °C, at pH 4 and 10 and with proteolytic enzymes, detergents and heavy metals. When analyzed by SDS-PAGE and overlaid with the indicator strains B. cereus and S. aureus, the 40% AS precipitate exhibited inhibitory activity on proteins smaller than 10 kDa. However, proteins larger than 25 kDa and smaller than 10 kDa were still observed on a native protein gel. Purified subtilosin A was prepared by Amberlite XAD-16 bead extraction and HPLC and analyzed by Nano-LC-QTOF-MS. Its molecular mass was found to be 3.4 kDa, and it retained its antibacterial activity. These results are consistent with the detection of the anti-listerial subtilosin A gene of the sbo/alb cluster in the KKU213 strain, which is 100% identical to that of B. subtilis subsp. subtilis 168. In addition to stable and cyclic subtilosin A, a mixture of many extracellular antibacterial peptides was also detected in the KKU213 culture. The KKU213 strain produced extracellular amylase, cellulase, lipase and protease, is highly acid-resistant (pH 2) when cultured in inulin and promotes health and reduces infection of intestinally colonized broiler chickens. Therefore, we propose that bacteriocin-producing B. subtilis KKU213 could be used as a potential probiotic strain or protective culture. PMID:25440998

  11. Radioimmunotherapy Using Vascular Targeted 213Bi: The Role of TNF-Alpha in the Development of Pulmonary Fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Davis, I.A.; Kennel, S.J.

    1998-10-14

    A monoclonal antibody (201B) specific to murine thrombomodulin, covalently linked to CHX-b-DTPA, successfully delivers chelated 213Bi, an {alpha}-particle emitter, (213Bi-201B) rapidly to lungvascular endothelium. When injected at doses of l MBq/mouse, 213Bi-201B destroyed most of the 100 colonies of EMT-6 mammary carcinomas growing as lung tumors of up to 2000 cells/colony. Some mice were cured of lung tumors and others had extended life-spans compared to untreated control animals but eventually succumbed to tumor recurrence. At injected doses of 4-6 MBq/mouse, 100% of lung tumor colonies were eliminated; however, 3-4 months later these mice developed pulmonary fibrosis and died. The mechanisms leading to the fibrotic response in other pulmonary irradiation models strongly implicate tumor necrosis factor-alpha (TNF-{alpha}), released from damaged tissues, as the pivotal inflammatory cytokine in a cascade of events which culminate in fibrosis. Attempts to prevent the development of pulmonary fibrosis, by using antibodies or soluble receptor (Enbrel{trademark}) as inhibitors of TNF-{alpha}, were unsuccessful. Additionally, mice genetically deficient for TNF-{alpha} production developed pulmonary fibrosis following 213Bi-201B treatment. Interestingly, non-tumor bearing BALB/c mice receiving Enbrel{trademark} or mice genetically deficient in TNF-{alpha} production and treated with 213Bi-201B, had significantly reduced life spans compared to mice receiving no treatment or 213Bi-201B alone. We speculate that, in normal mice, while TNF-{alpha} may induce an inflammatory response following {alpha}-particle radiation mediated tumor clearance and pulmonary damage, its effects in the post-tumor clearance time period may actually retard the development of fibrosis.

  12. 17DD and 17D-213/77 yellow fever substrains trigger a balanced cytokine profile in primary vaccinated children.

    Directory of Open Access Journals (Sweden)

    Ana Carolina Campi-Azevedo

    Full Text Available BACKGROUND: This study aimed to compare the cytokine-mediated immune response in children submitted to primary vaccination with the YF-17D-213/77 or YF-17DD yellow fever (YF substrains. METHODS: A non-probabilistic sample of eighty healthy primary vaccinated (PV children was selected on the basis of their previously known humoral immune response to the YF vaccines. The selected children were categorized according to their YF-neutralizing antibody titers (PRNT and referred to as seroconverters (PV-PRNT(+ or nonseroconverters (PV-PRNT(-. Following revaccination with the YF-17DD, the PV-PRNT(- children (YF-17D-213/77 and YF-17DD groups seroconverted and were referred as RV-PRNT(+. The cytokine-mediated immune response was investigated after short-term in vitro cultures of whole blood samples. The results are expressed as frequency of high cytokine producers, taking the global median of the cytokine index (YF-Ag/control as the cut-off. RESULTS: The YF-17D-213/77 and the YF-17DD substrains triggered a balanced overall inflammatory/regulatory cytokine pattern in PV-PRNT(+, with a slight predominance of IL-12 in YF-17DD vaccinees and a modest prevalence of IL-10 in YF-17D-213/77. Prominent frequency of neutrophil-derived TNF-α and neutrophils and monocyte-producing IL-12 were the major features of PV-PRNT(+ in the YF-17DD, whereas relevant inflammatory response, mediated by IL-12(+CD8(+ T cells, was the hallmark of the YF-17D-213/77 vaccinees. Both substrains were able to elicit particular but relevant inflammatory events, regardless of the anti-YF PRNT antibody levels. PV-PRNT(- children belonging to the YF-17DD arm presented gaps in the inflammatory cytokine signature, especially in terms of the innate immunity, whereas in the YF-17D-213/77 arm the most relevant gap was the deficiency of IL-12-producing CD8(+T cells. Revaccination with YF-17DD prompted a balanced cytokine profile in YF-17DD nonresponders and a robust inflammatory profile in YF-17D

  13. 17DD and 17D-213/77 Yellow Fever Substrains Trigger a Balanced Cytokine Profile in Primary Vaccinated Children

    Science.gov (United States)

    Luiza-Silva, Maria; Batista, Maurício Azevedo; Martins, Marina Angela; Sathler-Avelar, Renato; da Silveira-Lemos, Denise; Camacho, Luiz Antonio Bastos; de Menezes Martins, Reinaldo; de Lourdes de Sousa Maia, Maria; Farias, Roberto Henrique Guedes; da Silva Freire, Marcos; Galler, Ricardo; Homma, Akira; Ribeiro, José Geraldo Leite; Lemos, Jandira Aparecida Campos; Auxiliadora-Martins, Maria; Caldas, Iramaya Rodrigues; Elói-Santos, Silvana Maria; Teixeira-Carvalho, Andréa; Martins-Filho, Olindo Assis

    2012-01-01

    Background This study aimed to compare the cytokine-mediated immune response in children submitted to primary vaccination with the YF-17D-213/77 or YF-17DD yellow fever (YF) substrains. Methods A non-probabilistic sample of eighty healthy primary vaccinated (PV) children was selected on the basis of their previously known humoral immune response to the YF vaccines. The selected children were categorized according to their YF-neutralizing antibody titers (PRNT) and referred to as seroconverters (PV-PRNT+) or nonseroconverters (PV-PRNT−). Following revaccination with the YF-17DD, the PV-PRNT− children (YF-17D-213/77 and YF-17DD groups) seroconverted and were referred as RV-PRNT+. The cytokine-mediated immune response was investigated after short-term in vitro cultures of whole blood samples. The results are expressed as frequency of high cytokine producers, taking the global median of the cytokine index (YF-Ag/control) as the cut-off. Results The YF-17D-213/77 and the YF-17DD substrains triggered a balanced overall inflammatory/regulatory cytokine pattern in PV-PRNT+, with a slight predominance of IL-12 in YF-17DD vaccinees and a modest prevalence of IL-10 in YF-17D-213/77. Prominent frequency of neutrophil-derived TNF-α and neutrophils and monocyte-producing IL-12 were the major features of PV-PRNT+ in the YF-17DD, whereas relevant inflammatory response, mediated by IL-12+CD8+ T cells, was the hallmark of the YF-17D-213/77 vaccinees. Both substrains were able to elicit particular but relevant inflammatory events, regardless of the anti-YF PRNT antibody levels. PV-PRNT− children belonging to the YF-17DD arm presented gaps in the inflammatory cytokine signature, especially in terms of the innate immunity, whereas in the YF-17D-213/77 arm the most relevant gap was the deficiency of IL-12-producing CD8+T cells. Revaccination with YF-17DD prompted a balanced cytokine profile in YF-17DD nonresponders and a robust inflammatory profile in YF-17D-213/77 nonresponders

  14. Carbon Dioxide Clusters: (CO_2)_6 to (CO_2)13

    Science.gov (United States)

    McKellar, A. R. W.; Oliaee, J. Norooz; Dehghany, M.; Moazzen-Ahmadi, N.

    2011-06-01

    We recenty reported assignments of specific infrared bands in the CO_2 νb{3} region (˜2350 wn) to (CO_2)_6, (CO_2)_7, (CO_2)_9, (CO_2)10, (CO_2)11, (CO_2)12, and (CO_2)13. Spectra are obtained by direct absorption using a rapid-scan tuneable diode laser spectrometer to probe a pulsed supersonic slit-jet expansion and assignments are facilitated by recent calculations of Takeuchi based on the Murthy potential. (CO_2)_6 is a symmetric top with S_6 point group symmetry which can be thought of as a stack of two planar cyclic trimers. (CO_2)13 is also an S_6 symmetric top, and consists of a single CO_2 monomer surrounded by an slightly distorted icosahedral cage. The remaining clusters are asymmetric tops without symmetry. Here we report additional CO_2 cluster results. Calculations based on the SAPT-s potential indicate that the structure of (CO_2)10 may be slightly different from that given by Takeuchi/Murthy. An additional band is observed for each of (CO_2)13 and (CO_2)10. A feature observed at 2378.2 wn is assigned as a (CO_2)_6 parallel combination band involving the sum of a fundamental and a low-lying intermolecular vibration. Most significantly, two bands are assigned to a second isomer of (CO_2)_6. This is also a symmetric top, but now with S_4 symmetry. The two symmetric hexamer isomers observed spectroscopically correspond well with the lowest energy structures given by both the SAPT-s and Murthy intermolecular potentials. [1] J. Norooz Oliaee, M. Dehgany, N. Moazzen-Ahmadi, and A.R.W. McKellar, Phys. Chem. Chem. Phys. 13, 1297 (2011). [2] H. Takeuchi, J. Phys. Chem. A 107, 5703 (2008); C.S. Murthy, S.F. O'Shea, and I.R. McDonald, Mol. Phys. 50, 531 (1983). [3] R. Bukowski, J. Sadlej, B. Jeziorski, P. Jankowski, K. Szalewicz, S.A. Kucharski, H.L. Williams, and B.M. Rice, J. Chem. Phys. 110, 3785 (1999)

  15. Clinical Analysis of 213 Neonates with Community-acquired Pneumonia%新生儿社区感染性肺炎213例临床分析

    Institute of Scientific and Technical Information of China (English)

    刘华君; 许红波; 王太森; 刘文彬; 汤雪晴; 吕洁

    2014-01-01

    目的:分析新生儿社区感染性肺炎的临床特点。方法对213例新生儿社区感染性肺炎的临床资料进行回顾性分析。结果(1)临床表现和体征:气促173例,发绀128例,咳嗽137例,口吐白沫121例,发热86例,三凹征97例,肺部呼吸音粗87例,肺部闻及干湿啰音92例,黄疸95例。(2)病原学:痰培养阳性82例,其中革兰阴性杆菌64例。(3)感染指标:白细胞(WBC)升高108例,C反应蛋白升高40例,降钙素原升高87例。(4) X线胸片:双肺纹理增多、模糊,肺门影模糊137例,小点片状影31例。(5)心脏彩超检查有先心病116例。结论新生儿社区感染性肺炎的临床表现不典型,痰培养阳性率较低,感染指标特异性不高,X线胸片大多有改变,合并先心病的患儿患社区感染性肺炎的比例明显较高,因此诊断和治疗时需进行综合考虑。%Objective To analyze the clinical features of neonatal community-acquired pneumonia (CAP). Methods A retrospective analysis was made to the clinical data of 213 neonates with CAP. Results Clinical manifestations and physical signs: dyspnea was found in 173 ccases, cyanosis in 128 cases, cough in 137 cases, buccal foam in 121 cases, fever in 86 cases, three depression sign in 97 cases, crude breath in 87 cases, rales or rhonchi in 92 cases and jaundice in 95 cases;etiological study:out of 82 positive cases of spu-tum culture, there were 64 cases with Gram-positive bacteria;infection index:WBC increase was found in 108 cases, C-reactive pro-tein increase in 40 cases and procalcitionin ( PCT ) increase in 87 cases;chest X-ray findings:increased blur imaging of lung-marking and hilar was found in 137 cases and images of dotted flake shadows in 31 cases;cardiac color ultrasound indicated congenital heart dis-ease (CHD)) in 116 cases. Conclusions The clinical manifestations of neonatal CAP are atypical with low positive rate of sputum cul

  16. Neuropathic pain in patients with spinal cord injury: report of 213 patients

    Directory of Open Access Journals (Sweden)

    Manoel Jacobsen Teixeira

    2013-09-01

    Full Text Available Objective Management of neuropathic pain following spinal cord injury (SCI can be a frustrating experience for patients since it poses a therapeutic challenge. In this article the authors describe the clinical characteristics of a group of patients with pain after spinal cord injury. Methods In this retrospective study, 213 patients with SCI and neuropathic pain were assessed. We analyzed clinical characteristics, treatment options, and pain intensity for these patients. Results The main cause of SCI was spine trauma, which occurred in 169 patients, followed by tumors and infection. Complete lesions were verified in 144 patients. In our study, patients with traumatic SCI and partial lesions seem to be presented with more intense pain; however, this was not statistically significant. Conclusions Neuropathic pain is a common complaint in patients with SCI and presents a treatment challenge. Knowledge of the clinical characteristics of this group of patients may help determine the best approach to intervention.

  17. Light Curves of 213 Type Ia Supernovae from the ESSENCE Survey

    CERN Document Server

    Narayan, Gautham; Tucker, Brad E; Foley, Ryan J; Wood-Vasey, W Michael; Challis, Peter; Stubbs, Christopher W; Kirshner, Robert P; Aguilera, Claudio; Becker, Andrew C; Blondin, Stephane; Clocchiatti, Alejandro; Covarrubias, Ricardo; Damke, Guillermo; Davis, Tamara M; Filippenko, Alexei V; Ganeshalingam, Mohan; Garg, Arti; Garnavich, Peter M; Hicken, Malcolm; Jha, Saurabh W; Krisciunas, Kevin; Leibundgut, Bruno; Li, Weidong; Matheson, Thomas; Miknaitis, Gajus; Pignata, Guiliano; Prieto, Jose Luis; Riess, Adam G; Schmidt, Brian P; Silverman, Jeffrey M; Smith, R Chris; Sollerman, Jesper; Spyromilio, Jason; Suntzeff, Nicholas B; Tonry, John L; Zenteno, Alfredo

    2016-01-01

    The ESSENCE survey discovered 213 Type Ia supernovae at redshifts 0.1 < z < 0.81 between 2002 and 2008. We present their R and I-band photometry, measured from images obtained using the MOSAIC II camera at the CTIO 4 m Blanco telescope, along with rapid-response spectroscopy for each object. We use our spectroscopic follow-up observations to determine an accurate, quantitative classification and a precise redshift. Through an extensive calibration program we have improved the precision of the CTIO Blanco natural photometric system. We use several empirical metrics to measure our internal photometric consistency and our absolute calibration of the survey. We assess the effect of various potential sources of systematic bias on our measured fluxes, and we estimate that the dominant term in the systematic error budget from the photometric calibration on our absolute fluxes is ~1%.

  18. The effect of low temperature on the scintillation efficiency of liquid scintillator NE 213

    Energy Technology Data Exchange (ETDEWEB)

    Ul-Haq, F.; Butt, M.Z.; Ali, W.; Jamil, S.; Durrani, S.A. (Government Coll., Lahore (Pakistan). Nuclear Research Lab.)

    1990-01-01

    The scintillation response of the liquid scintillator NE 213 has been studied as function of temperature in the range 225 to 300 K. It has been found that the light output under gamma excitation increases with decrease in temperature. The data are well represented by the relation: I{sub low} - I = I{sub 0} exp(- E/kT), where I is the count rate at temperature T, I{sub low} is a constant equal to 750 counts/minute, the pre-exponential factor I{sub 0} is 15 x 10{sup 5} counts/minute, k is the Boltzmann constant and E is the activation energy equal to 0.21 eV, which is typical for a diffusion controlled process in the temperature range studied. (author).

  19. Safety improvement and results of commissioning of Mochovce NPP WWER 440/213

    International Nuclear Information System (INIS)

    Mochovce NPP is the last one of this kind and compared to its predecessors, it is characterized by several modifications which contribute to the improvement of the safety level. In addition based on Nuclear Regulatory Authority requirements and based on documents: - IAEA - Safety Issues and their ranking for NPP WWER 440/213, - IAEA - Safety Improvement of Mochovce NPP Project Review Mission, - Riskaudit - Evaluation of the Mochovce NPP Safety Improvements. Additional safety measures have been implemented before commissioning. The consortium EUCOM (FRAMATOME - SIEMENS), SKODA Praha, ENERGOPROJEKT Praha, Russian organizations and VUJE Trnava Nuclear Power Plants research institute were selected for design and implementation of the safety measures. The papers summarized, safety requirements, safety measures implemented, results of commissioning and results of safety analysis report evaluation. (author)

  20. Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera.

    Science.gov (United States)

    Sun, Zhihong; Harris, Hugh M B; McCann, Angela; Guo, Chenyi; Argimón, Silvia; Zhang, Wenyi; Yang, Xianwei; Jeffery, Ian B; Cooney, Jakki C; Kagawa, Todd F; Liu, Wenjun; Song, Yuqin; Salvetti, Elisa; Wrobel, Agnieszka; Rasinkangas, Pia; Parkhill, Julian; Rea, Mary C; O'Sullivan, Orla; Ritari, Jarmo; Douillard, François P; Paul Ross, R; Yang, Ruifu; Briner, Alexandra E; Felis, Giovanna E; de Vos, Willem M; Barrangou, Rodolphe; Klaenhammer, Todd R; Caufield, Page W; Cui, Yujun; Zhang, Heping; O'Toole, Paul W

    2015-09-29

    Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species.

  1. Light Curves of 213 Type Ia Supernovae from the ESSENCE Survey

    Science.gov (United States)

    Narayan, G.; Rest, A.; Tucker, B. E.; Foley, R. J.; Wood-Vasey, W. M.; Challis, P.; Stubbs, C.; Kirshner, R. P.; Aguilera, C.; Becker, A. C.; Blondin, S.; Clocchiatti, A.; Covarrubias, R.; Damke, G.; Davis, T. M.; Filippenko, A. V.; Ganeshalingam, M.; Garg, A.; Garnavich, P. M.; Hicken, M.; Jha, S. W.; Krisciunas, K.; Leibundgut, B.; Li, W.; Matheson, T.; Miknaitis, G.; Pignata, G.; Prieto, J. L.; Riess, A. G.; Schmidt, B. P.; Silverman, J. M.; Smith, R. C.; Sollerman, J.; Spyromilio, J.; Suntzeff, N. B.; Tonry, J. L.; Zenteno, A.

    2016-05-01

    The ESSENCE survey discovered 213 Type Ia supernovae at redshifts 0.1\\lt z\\lt 0.81 between 2002 and 2008. We present their R- and I-band photometry, measured from images obtained using the MOSAIC II camera at the CTIO Blanco, along with rapid-response spectroscopy for each object. We use our spectroscopic follow-up observations to determine an accurate, quantitative classification, and precise redshift. Through an extensive calibration program we have improved the precision of the CTIO Blanco natural photometric system. We use several empirical metrics to measure our internal photometric consistency and our absolute calibration of the survey. We assess the effect of various potential sources of systematic bias on our measured fluxes, and estimate the dominant term in the systematic error budget from the photometric calibration on our absolute fluxes is ˜1%.

  2. Models of Five Absorption Line Systems Along the Line of Sight Toward PG0117+213

    CERN Document Server

    Masiero, J R; Ding, J; Churchill, C W; Kacprzak, G G

    2005-01-01

    We present our investigation into the physical conditions of the gas in five intervening quasar absorption line systems along the line of sight toward the quasar PG 0117+213, with redshifts of z=0.57, z=0.72, z=1.04, z=1.32 and z=1.34. Photoionization modeling of HST, Keck I, and Palomar data, using the code Cloudy, is employed to derive densities and metallicities of the multiple phases of gas required to fit the absorption profile for each system. We discuss the implications of these models for galaxy evolution, including the interpretation of ``CIV deficiency'' and damped Lyman alpha absorbers (DLAs), and the relationships between galaxy morphology, galaxy luminosity, and absorption signature.

  3. 75 FR 44306 - Eleventh Meeting: Joint RTCA Special Committee 213: EUROCAE WG-79: Enhanced Flight Vision Systems...

    Science.gov (United States)

    2010-07-28

    ... Federal Aviation Administration Eleventh Meeting: Joint RTCA Special Committee 213: EUROCAE WG- 79... September 21-23, 2010 from 8:30 a.m.--5 p.m. (0830-1700). ADDRESSES: The meeting will be held at the London... Systems/Synthetic Vision Systems (EFVS/SVS) meeting. The agenda will include: Tuesday, 21...

  4. Substituted 2,1,3-Benzothiadiazole- And Thiophene-Based Polymers for Solar Cells - Introducing a New Thermocleavable Precursor

    DEFF Research Database (Denmark)

    Petersen, Martin Helgesen; Gevorgyan, Suren; Krebs, Frederik C;

    2009-01-01

    Alkoxysubstituted and unsubstituted 2,1,3-benzothiadiazoles were prepared and copolymerized with substituted and unsubstituted thiophenes using both Stille and Yamamoto cross-coupling reactions. One class of the materials bore thermally labile ester groups. The materials were all found to have...

  5. 47 CFR 68.213 - Installation of other than “fully protected” non-system simple customer premises wiring.

    Science.gov (United States)

    2010-10-01

    ... TELEPHONE NETWORK Terminal Equipment Approval Procedures § 68.213 Installation of other than “fully... residential and business telephone service. More complex installations of wiring for multiple line services, for use with systems such as PBX and key telephone systems, are controlled by § 68.215 of these...

  6. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development.

    Directory of Open Access Journals (Sweden)

    Wanyang Liu

    Full Text Available BACKGROUND: Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its susceptibility locus has been mapped to 17q25.3 in Japanese families, but the susceptibility gene is unknown. METHODOLOGY/PRINCIPAL FINDINGS: Genome-wide linkage analysis in eight three-generation families with moyamoya disease revealed linkage to 17q25.3 (P<10(-4. Fine mapping demonstrated a 1.5-Mb disease locus bounded by D17S1806 and rs2280147. We conducted exome analysis of the eight index cases in these families, with results filtered through Ng criteria. There was a variant of p.N321S in PCMTD1 and p.R4810K in RNF213 in the 1.5-Mb locus of the eight index cases. The p.N321S variant in PCMTD1 could not be confirmed by the Sanger method. Sequencing RNF213 in 42 index cases confirmed p.R4810K and revealed it to be the only unregistered variant. Genotyping 39 SNPs around RNF213 revealed a founder haplotype transmitted in 42 families. Sequencing the 260-kb region covering the founder haplotype in one index case did not show any coding variants except p.R4810K. A case-control study demonstrated strong association of p.R4810K with moyamoya disease in East Asian populations (251 cases and 707 controls with an odds ratio of 111.8 (P = 10(-119. Sequencing of RNF213 in East Asian cases revealed additional novel variants: p.D4863N, p.E4950D, p.A5021V, p.D5160E, and p.E5176G. Among Caucasian cases, variants p.N3962D, p.D4013N, p.R4062Q and p.P4608S were identified. RNF213 encodes a 591-kDa cytosolic protein that possesses two functional domains: a Walker motif and a RING finger domain. These exhibit ATPase and ubiquitin ligase activities. Although the mutant alleles (p.R4810K or p.D4013N in the RING domain did not affect transcription levels or ubiquitination activity, knockdown of RNF213 in zebrafish caused irregular wall formation in trunk arteries and abnormal sprouting vessels. CONCLUSIONS/SIGNIFICANCE: We provide evidence suggesting, for the first

  7. Double-pulse laser ablation sampling: Enhancement of analyte emission by a second laser pulse at 213 nm

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Bruno Yue [Laser Technologies Group, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China); Mao, Xianglei [Laser Technologies Group, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Hou, Huaming [Laser Technologies Group, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Ocean University of China, Qingdao (China); Zorba, Vassilia; Russo, Richard E. [Laser Technologies Group, Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Cheung, Nai-Ho, E-mail: nhcheung@hkbu.edu.hk [Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China)

    2015-08-01

    For the purpose of devising methods for minimally destructive multi-element analysis, we compare the performance of a 266 nm–213 nm double-pulse scheme against that of the single 266 nm pulse scheme. The first laser pulse at 266 nm ablates a mica sample. Ten ns later, the second pulse at 213 nm and 64 mJ cm{sup −2} orthogonally intercepts the gas plume to enhance the analyte signal. Emissions from aluminum, silicon, magnesium and sodium are simultaneously observed. At low 266 nm laser fluence when only sub-ng of sample mass is removed, the signal enhancement by the 213 nm pulse is especially apparent. The minimum detectable amount of aluminum is about 24 fmol; it will be a hundred times higher if the sample is analyzed by the 266 nm pulse alone. The minimum detectable mass for the other analytes is also reduced by about two orders of magnitude when the second pulse at 213 nm is introduced. The spectral and temporal properties of the enhanced signal are consistent with the mechanism of ultra-violet laser excited atomic fluorescence of dense plumes. - Highlights: • We devise a two-laser-pulse scheme to analyze the elemental composition of mica as test samples. • We compare the analytical performance of the single 266 nm pulse scheme against the 266 nm – 213 nm two pulse scheme. • The two pulse scheme improves the absolute LODs of the analytes by about a hundred times. • The spectral and temporal properties of the enhanced signal are consistent with the mechanism.

  8. EVN Observations of HESS J1943+213: Evidence for an Extreme TeV BL Lac Object

    Science.gov (United States)

    Akiyama, Kazunori; Stawarz, Łukasz; Tanaka, Yasuyuki T.; Nagai, Hiroshi; Giroletti, Marcello; Honma, Mareki

    2016-06-01

    We report on the 1.6 GHz (18 cm) very long baseline interferometry (VLBI) observations of the unresolved, steady TeV source HESS J1943+213 located in the Galactic plane, performed with the European VLBI Network (EVN) in 2014. Our new observations with a nearly full EVN array provide the deepest image of HESS J1943+213 at the highest resolution ever achieved, enabling us to resolve the long-standing issues of the source identification. The milliarcsecond-scale structure of HESS J1943+213 has a clear asymmetric morphology consisting of a compact core and a diffuse jet-like tail. This is broadly consistent with the previous e-EVN observations of the source performed in 2011 and re-analyzed in this work. The core component is characterized by the brightness temperature of ≳ 1.8× {10}9 K, which is typical for low-luminosity blazars in general. Overall, the radio properties of HESS J1943+213 are consistent with the source classification as an “extreme high-frequency-peaked BL Lac object.” Remarkably, we note that because HESS J1943+213 does not reveal any optical or infrared signatures of the active galactic nucleus activity, it would never be recognized and identified as a BL Lac object if not for its location close to the Galactic plane where the High Energy Stereoscopic System surveyed for and the follow-up dedicated X-ray and radio studies triggered by the source detection in the TeV range. Our results suggest, therefore, a presence of an unrecognized, possibly very numerous population of particularly extreme HBLs and simultaneously demonstrate that the low-frequency VLBI observations with high angular resolution are indispensable for a proper identification of such objects.

  9. Cell death triggered by alpha-emitting {sup 213}Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death

    Energy Technology Data Exchange (ETDEWEB)

    Seidl, Christof; Schroeck, Hedwig; Seidenschwang, Sabine; Beck, Roswitha; Schwaiger, Markus; Senekowitsch-Schmidtke, Reingard [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Schmid, Ernst [National Research Center for Environment and Health, Institute of Radiation Biology, GSF, Neuherberg (Germany); Abend, Michael [German Armed Forces, Institute of Radiobiology, Munich (Germany); Becker, Karl-Friedrich [Technische Universitaet Muenchen, Institute of Pathology, Munich (Germany); National Research Center for Environment and Health, Institute of Pathology, GSF, Neuherberg (Germany); National Research Center for Environment and Health, Institute of Molecular Immunology, GSF, Munich (Germany); Apostolidis, Christos; Nikula, Tuomo K. [European Commission, Institute for Transuranium Elements, Karlsruhe (Germany); Kremmer, Elisabeth [National Research Center for Environment and Health, Institute of Molecular Immunology, GSF, Munich (Germany)

    2005-03-01

    Radioimmunotherapy with {alpha}-particle-emitting nuclides, such as{sup 213}Bi, is a promising concept for the elimination of small tumour nodules or single disseminated tumour cells. The aim of this study was to investigate cellular damage and the mode of cell death triggered by {sup 213}Bi-immunoconjugates. Human gastric cancer cells (HSC45-M2) expressing d9-E-cadherin were incubated with different levels of activity of {sup 213}Bi-d9MAb targeting d9-E-cadherin and {sup 213}Bi-d8MAb, which does not bind to d9-E-cadherin. Micronucleated (M) cells, abnormal (A) cells and apoptotic (A) [(MAA)] cells were scored microscopically in the MAA assay following fluorescent staining of nuclei and cytoplasm. Chromosomal aberrations were analysed microscopically following Giemsa staining. The effect of z-VAD-fmk, known to inhibit apoptosis, on the prevention of cell death was investigated following treatment of HSC45-M2 cells with sorbitol as well as {sup 213}Bi-d9MAb. Activation of caspase 3 after incubation of HSC45-M2 cells with both sorbitol and {sup 213}Bi-d9MAb was analysed via Western blotting. Following incubation of HSC45-M2 human gastric cancer cells expressing d9-E-cadherin with {sup 213}Bi-d9MAb the number of cells killed increased proportional to the applied activity concentration. Microscopically visible effects of {alpha}-irradiation of HSC45-M2 cells were formation of micronuclei and severe chromosomal aberrations. Preferential induction of these lesions with specific {sup 213}Bi-d9MAb compared with unspecific {sup 213}Bi-d8MAb (not targeting d9-E-cadherin) was not observed if the number of floating, i.e. unbound {sup 213}Bi-immunoconjugates per cell exceeded 2 x 10{sup 4}, most likely due to intense crossfire. In contrast to sorbitol-induced cell death, cell death triggered by {sup 213}Bi-immunoconjugates was independent of caspase 3 activation and could not be inhibited by z-VAD-fmk, known to suppress the apoptotic pathway. {sup 213}Bi-immunoconjugates seem

  10. Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death

    International Nuclear Information System (INIS)

    Radioimmunotherapy with α-particle-emitting nuclides, such as213Bi, is a promising concept for the elimination of small tumour nodules or single disseminated tumour cells. The aim of this study was to investigate cellular damage and the mode of cell death triggered by 213Bi-immunoconjugates. Human gastric cancer cells (HSC45-M2) expressing d9-E-cadherin were incubated with different levels of activity of 213Bi-d9MAb targeting d9-E-cadherin and 213Bi-d8MAb, which does not bind to d9-E-cadherin. Micronucleated (M) cells, abnormal (A) cells and apoptotic (A) [(MAA)] cells were scored microscopically in the MAA assay following fluorescent staining of nuclei and cytoplasm. Chromosomal aberrations were analysed microscopically following Giemsa staining. The effect of z-VAD-fmk, known to inhibit apoptosis, on the prevention of cell death was investigated following treatment of HSC45-M2 cells with sorbitol as well as 213Bi-d9MAb. Activation of caspase 3 after incubation of HSC45-M2 cells with both sorbitol and 213Bi-d9MAb was analysed via Western blotting. Following incubation of HSC45-M2 human gastric cancer cells expressing d9-E-cadherin with 213Bi-d9MAb the number of cells killed increased proportional to the applied activity concentration. Microscopically visible effects of α-irradiation of HSC45-M2 cells were formation of micronuclei and severe chromosomal aberrations. Preferential induction of these lesions with specific 213Bi-d9MAb compared with unspecific 213Bi-d8MAb (not targeting d9-E-cadherin) was not observed if the number of floating, i.e. unbound 213Bi-immunoconjugates per cell exceeded 2 x 104, most likely due to intense crossfire. In contrast to sorbitol-induced cell death, cell death triggered by 213Bi-immunoconjugates was independent of caspase 3 activation and could not be inhibited by z-VAD-fmk, known to suppress the apoptotic pathway. 213Bi-immunoconjugates seem to induce a mode of cell death different from apoptosis in HSC45-M2 cells. (orig.)

  11. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 213, Revision 1 (FGE.213Rev1): Consideration of genotoxic potential for α , β -Unsaturated Alicyclic ketones and precursors from chemical subgroup

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Lund, Pia;

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 26 flavouring substances from subgroup 2.7 of FGE.19 in the Flavouring Group Evaluation 213. In the first version of FGE.213 the...

  12. Report of a consultants meeting on draft guidelines for WWER 440/213 containment evaluation

    International Nuclear Information System (INIS)

    This report has been prepared at two Consultants' Meetings of experts from France, Germany, Russia, Slovakia, Spain and Ukraine, organized within the framework of the IAEA Extrabudgetary Programme on the Safety of WWER NPPs. In view of the limited time available and the complexity of the task the present report should be treated as a draft, which will be sent to the national regulatory bodies for review and further improvement. The next meeting on the subject will be held in June 1996 with the participation of representatives of all countries operating WWER 440/213 reactors with bubbler condenser containments. During the meeting, the acceptance criteria and review requirements formulated in the IAEA NUSS Series and those in force in the Russian Federation, the United States of America, Germany, France, the Czech Republic, and Slovakia have been taken into consideration. The equivalence of the technical goals which are aimed to be achieved by applying comparable national criteria has been checked in order to avoid multiple addressing the issues and to assure the completeness of the acceptance criteria necessary to assess the design of the containment systems. 48 refs, 12 tabs

  13. Completion of the VVER 440/213 NPP Mochovce incorporation enhanced safety features

    International Nuclear Information System (INIS)

    The cooperation between the western countries and the countries of ex-eastern block in the field of nuclear safety is recent and still limited. The main reasons for this situation are limited or non existent capabilities of these countries for financing as well as non acceptable legal conditions concerning the third party nuclear liability in this part of Europe. Nevertheless, Framatome and Siemens associated in the consortium named EUCOM, have signed in April 1996 the contract of about 100 million US dollars with Slovak electricity company (SLOVENSKE ELEKTRARNE-SE) for upgrading the Units 1 and 2 of Mochovce Nuclear Power Plant according to the western safety standards. This is the first important project involving west-european companies in the modernisation of Russian type of pressurized water reactor (VVER 440/213). The consortium will cooperate with other partners involved in the project: Slovak, Czech and Russian. The financing of the project will be provided mainly form Slovak and Czech sources. The safety upgrading will be financed through French and German buyer credits. French company Electricite de France (EDF) will be the consultant for SE. The safety upgrading measures have been elaborated taking into account the recommendation of Vienna International Atomic Energy Agency (IAEA) and the evaluation of the safety realised by RISKAUDIT, the common organization of German and French safety authorities (GSR and IPSN). Hence all guaranties have been taken to fulfil the western safety criteria for Nuclear Power Plant Mochovce. (author)

  14. The erosion-corrosion performance of SA213-T22 steel in low velocity conditions

    Science.gov (United States)

    Chacón-Nava, J. G.; Martínez-Villafañe, A.; Almeraya-Calderón, F. M.; Stott, F. H.; González-Rodríguez, J. G.

    2001-12-01

    The erosion-corrosion (E-C) behavior of SA213-T22 steel has been studied in a laboratory fluidized-bed (FB) facility in the temperature range from 100 to 600 °C. Tests were carried out on pin specimens in air using alumina particles of 560 µm average size at impact velocities from 1.5 to 4.5 m/s. The trends of wear with temperature showed small weight gains at velocities up to 1.5 m/s. Erodent deposition was a dominant process at temperatures below about 300 °C and velocities below about 2 m/s. At higher velocities, a peak wastage temperature was observed at about 350 °C. The wastage/temperature curves observed in both cases suggested four temperature regions. In each region, a different E-C regime operates. Scanning electron microscopy (SEM) revealed various wastage mechanisms, i.e., (a) oxide chipping, (b) development of a compact and adherent oxide scale, (c) oxide and metal removal, and (d) fracture and spalling within the oxide layer and at the scale/metal interface. In the present study, the latter mechanism was responsible for the high wastage rates observed at temperatures above about 450 °C and impact velocities above 3.5 m/s.

  15. Spin vectors in the Koronis family: comprehensive results from two independent analyses of 213 rotation lightcurves

    Science.gov (United States)

    Slivan, Stephen M.; Binzel, Richard P.; Crespo da Silva, Lucy D.; Kaasalainen, Mikko; Lyndaker, Mariah M.; Krčo, Marko

    2003-04-01

    Observations of Koronis asteroid family members (158) Koronis, (277) Elvira, (311) Claudia, (321) Florentina, and (720) Bohlinia made during the period 1998-2001 yielded 61 new individual rotation lightcurves to augment previous surveys (R.P. Binzel, 1987, Icarus 72, 135-208; S.M. Slivan, R.P. Binzel, 1996, Icarus 124, 452-470) and allow determination of the senses of rotation and spin vector orientations for these objects. Spin vector reductions were performed on these five objects and also on family members (167) Urda, (208) Lacrimosa, (534) Nassovia, and (1223) Neckar using both a combination of amplitude-magnitude and epoch methods and a convex inversion method. A total of 213 individual lightcurves were analyzed to determine sidereal rotation periods, pole solutions and obliquities, associated photometric parameters, and model shapes for each object. We checked our methods and results using the (243) Ida Master Dataset of lightcurves (R. P. Binzel et al., 1993, Icarus 105, 310-325) and found that the true pole determined from the Galileo fly by of this irregularly shaped member of the Koronis family falls just at the edge of the estimated uncertainty of our own solution. Our findings for the spin vector distribution of 10 members within the Koronis family represent the first systematic study of spin states within a well-established Hirayama family, and provide observational constraints for models of the physics of family formation and spin vector evolution in the main belt.

  16. Optoelectronic properties of fluorene-co-4,7-difuran-2,1,3-benzothiadiazole copolymers

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Light-emitting and photovoltaic properties of copolymers(PFO-FBT) based on 9,9-dioctylfluorene and 4,7-difuran-2,1,3-benzothiadiazole(FBT) units were investigated.The copolymers show two absorbance peaks at around 382 nm and 530 nm,respectively.The relative absorbance at around 530 nm of the PFO-FBT copolymers increases with the increasing FBT content.The EL emissions are red-shifted from 611 nm to 702 nm by increasing the FBT content in the copolymer.The highest EL external quantum efficiency achieved with the device configuration of ITO/PEDOT/PVK/PFO-FBT0.1/Ba/Al is 2.32% with the luminance of 441.3 cd/m2 at a current density of 33 mA/cm2.Efficient energy transfer due to exciton trapping on low band-gap FBT sites was observed.The bulk-heterojunction photovoltaic cell used PFO-FBT50 copolymer as the electron donor and methanofullerene [6,6]-phenyl C61-butyric acid methyl ester(PCBM) as the electron acceptor shows an energy conversion efficiency of 1.13% with open-circuit voltage(Voc) of 0.85 V and short-circuit current density(Jsc) of 3.39 mA/cm2 under AM 1.5 solar simulator(100 mW/cm2),and the edge of the spectral photoresponse is at ~750 nm.

  17. Cores, filaments, and bundles: hierarchical core formation in the L1495/B213 Taurus region

    CERN Document Server

    Hacar, A; Kauffmann, J; Kovacs, A

    2013-01-01

    (Abridged) Context. Core condensation is a critical step in the star-formation process, but is still poorly characterized observationally. Aims. We have studied the 10 pc-long L1495/B213 complex in Taurus to investigate how dense cores have condensed out of the lower-density cloud material. Results. From the N$_2$H$^+$ emission, we identify 19 dense cores, some starless and some protostellar. They are not distributed uniformly, but tend to cluster with relative separations on the order of 0.25 pc. From the C$^{18}$O emission, we identify multiple velocity components in the gas. We have characterized them by fitting gaussians to the spectra, and by studying the distribution of the fits in position-position-velocity space. In this space, the C$^{18}$O components appear as velocity-coherent structures, and we have identified them automatically using a dedicated algorithm (FIVe: Friends In Velocity). Using this algorithm, we have identified 35 filamentary components with typical lengths of 0.5 pc, sonic internal ...

  18. VERITAS Observations of the Unidentified Point Source HESS J1943+213

    CERN Document Server

    ,

    2015-01-01

    The H.E.S.S. Galactic plane scan has revealed a large population of Galactic very high energy (VHE; E > 100 GeV) emitters. The majority of the galactic sources are extended and can typically be associated with pulsar wind nebulae (35%) and supernova remnants (21%), while some of the sources remain unidentified (31%). A much smaller fraction of point-like sources (5 in total, corresponding to 4%) are identified as gamma-ray binaries. Active galactic nuclei located behind the Galactic plane are also a potential source class. An active galaxy could be identified in the VHE regime by a point like extension, a high variability amplitude (up to a factor of 100) and a typically soft spectrum (due to absorption by the extra-galactic background light). Here we report on VERITAS observations of HESS J1943+213, an unidentified point source discovered to emit above 470 GeV during the extended H.E.S.S. Galactic plane scan. This source is thought to be a distant BL Lac object behind the Galactic plane and, though it exhibi...

  19. 1,213 Cases of Treatment of Facial Acne Using Indocyanine Green and Intense Pulsed Light in Asian Skin

    Directory of Open Access Journals (Sweden)

    Kui Young Park

    2015-01-01

    Full Text Available Background. Photodynamic therapy (PDT has been used for acne, with various combinations of photosensitizers and light sources. Objective. We evaluated the effectiveness and safety of indocyanine green (ICG and intense pulsed light (IPL in the treatment of acne. Materials and Methods. A total of 1,213 patients with facial acne were retrospectively reviewed. Patients received three or five treatments of ICG and IPL at two-week intervals. Clinical response to treatment was assessed by comparing pre- and posttreatment clinical photographs and patient satisfaction scores. Results. Marked to excellent improvement was noted in 483 of 1,213 (39.8% patients, while minimal to moderate improvement was achieved in the remaining 730 (60.2% patients. Patient satisfaction scores revealed that 197 (16.3% of 1,213 patients were highly satisfied, 887 (73.1% were somewhat satisfied, and 129 (10.6% were unsatisfied. There were no significant side effects. Conclusion. These results suggest that PDT with ICG and IPL can be effectively and safely used in the treatment of acne.

  20. Design basis and design features of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia)

    International Nuclear Information System (INIS)

    The prime objective of the IAEA Technical Co-operation Project on Evaluation of Safety Aspects of WWER-440 model 213 NPPs is to co-ordinate and to integrate assistance to national organizations in studying selected aspects of safety for the same type of reactors. Consequently, the study integrated the results generated by national activities carried out in the Czech Republic, Hungary, Slovakia and Ukraine and co-ordinated through the IAEA. Valuable assistance in carrying out the tasks was also provided by Bulgaria and Poland. A set of publications is being prepared to present the results of the project. The publications are intended to facilitate the review and utilization of the results of the project. They are also providing assistance in further refinement and/or extension of plant specific safety evaluation of model 213 NPPs. This Technical Document addressing the design basis and safety related design features of WWER-440 model 213 plants is the first of the series to be published. It is hoped that this document will be useful to anyone working in the field of WWER safety, and in particular to experts planning, executing or reviewing studies related to the subject. Refs, 36 figs, tabs

  1. The status of the Bubbler Condenser Containment System for the Reactors of the VVER-440/213 Type

    International Nuclear Information System (INIS)

    VVER-440/213 Pressurized Water Reactors have a pressure-suppression containment structure called a 'Bubbler Condenser' tower which can reduce the design pressure of the entire containment following a design basis accident (DBA), such as a loss-of-coolant accident (LOCA). The bubbler condenser pressure suppression system provides reduction of the LOCA containment pressure by the condensation of released steam in a water pool. World-wide there are 14 nuclear power plants of the VVER-440/213 type in Eastern Europe and Russia. One of the safety concerns for the VVER-440/213 reactors relates to the ability of the bubbler condenser containment system to function satisfactorily and to maintain its integrity following certain postulated accidents and thus limit the release of radioactive material to the environment. The complicated geometry of the bubbler condenser unit, and the dependence on several moving devices and interlocks are the main doubts expressed by different specialists with regard to the design. General description of the bubbler condenser containment system, the physical processes, concerns and design assessment of the bubbler condenser containment system, presentation of the OECD's Unified Bubbler Condenser Research Project (UBCRP) and the European Commission PHARE/TACIS project. Recent utility investigations are also discussed

  2. Methemoglobin-forming effect and its role in the mechanism of action of some radioprotectors of benzo-2,1,3-thiadiazole class

    International Nuclear Information System (INIS)

    The ability of some benzo-2,1,3-tiadiazole derivatives to form methemoglobin in blood has been investigated. It has been shown that 30 min after intraperitoneal administration to mice of radioprotective doses of the preparations, the methemoglobin level in blood does not exceed 5%. After administration of a toxic dose of 4-aminobenzo-2,1,3-tiadiazole, the amount of methemoglobin in the mouse blood makes 14%. After per os administration of 4-aminobenzo-2,1,3-tiadiazole to dogs methemoglobin content of blood makes almost 50% which can provide a radioprotective action of this compound. Using substances preventing oxidation of hemoglobin to methemoglobin (isonicotinic acid hydrazide and 2-methoxy-9-phenazin sulphate) it has been shown that methemoglobin, formed in the mouse blood, does not play a leading part in manifestation of radioprotective and toxic properties of 4-aminobenzo-2,1,3-tiadiazole

  3. CFD evaluation of hydrogen risk mitigation measures in a VVER-440/213 containment

    Energy Technology Data Exchange (ETDEWEB)

    Heitsch, Matthias, E-mail: Matthias.Heitsch@ec.europa.e [Institute for Energy, Joint Research Centre, PO Box 2, 1755 ZG Petten (Netherlands); Huhtanen, Risto [VTT Technical Research Centre of Finland, PO Box 1000, FI-02044 VTT (Finland); Techy, Zsolt [VEIKI Institute for Electric Power Research Co., PO Box 80, H-1251 Budapest (Hungary); Fry, Chris [Serco, Winfrith Technology Centre, Dorchester, Dorset DT2 8DH (United Kingdom); Kostka, Pal [VEIKI Institute for Electric Power Research Co., PO Box 80, H-1251 Budapest (Hungary); Niemi, Jarto [VTT Technical Research Centre of Finland, PO Box 1000, FI-02044 VTT (Finland); Schramm, Berthold [Gesellschaft fuer Anlagen- und Reaktorsicherheit, GRS mbH, Schwertnergasse 1, 50667 Koeln (Germany)

    2010-02-15

    In the PHARE project 'Hydrogen Management for the VVER440/213' (HU2002/000-632-04-01), CFD (Computational Fluid Dynamics) calculations using GASFLOW, FLUENT and CFX were performed for the Paks NPP (Nuclear Power Plant), modelling a defined severe accident scenario which involves the release of hydrogen. The purpose of this work is to demonstrate that CFD codes can be used to model gas movement inside a containment during a severe accident. With growing experience in performing such analyses, the results encourage the use of CFD in assessing the risk of losing containment integrity as a result of hydrogen deflagrations. As an effective mitigation measure in such a situation, the implementation of catalytic recombiners is planned in the Paks NPP. In order to support these plans both unmitigated and recombiner-mitigated simulations were performed. These are described and selected results are compared. The codes CFX and FLUENT needed refinement to their models of wall and bulk steam condensation in order to be able to fully simulate the severe accident under consideration. Several CFD codes were used in parallel to model the same accident scenario in order to reduce uncertainties in the results. Previously it was considered impractical to use CFD codes to simulate a full containment subject to a severe accident extending over many hours. This was because of the expected prohibitive computing times and missing physical capabilities of the codes. This work demonstrates that, because of developments in the capabilities of CFD codes and improvements in computer power, these calculations have now become feasible.

  4. Targeted alpha-therapy using [Bi-213]anti-CD20 as novel treatment option for radio- and chemoresistant non-Hodgkin lymphoma cells

    Science.gov (United States)

    Roscher, Mareike; Hormann, Inis; Leib, Oliver; Marx, Sebastian; Moreno, Josue; Miltner, Erich; Friesen, Claudia

    2013-01-01

    Radioimmunotherapy (RIT) is an emerging treatment option for non-Hodgkin lymphoma (NHL) producing higher overall response and complete remission rates compared with unlabelled antibodies. However, the majority of patients treated with conventional or myeloablative doses of radiolabelled antibodies relapse. The development of RIT with alpha-emitters is attractive for a variety of cancers because of the high linear energy transfer (LET) and short path length of alpha-radiation in human tissue, allowing higher tumour cell kill and lower toxicity to healthy tissues. In this study, we investigated the molecular effects of the alpha-emitter Bi-213 labelled to anti-CD20 antibodies ([Bi-213]anti-CD20) on cell cycle and cell death in sensitive and radio-/chemoresistant NHL cells. [Bi-213]anti-CD20 induced apoptosis, activated caspase-3, caspase-2 and caspase-9 and cleaved PARP specifically in CD20-expressing sensitive as well as in chemoresistant, beta-radiation resistant and gamma-radiation resistant NHL cells. CD20 negative cells were not affected by [Bi-213]anti-CD20 and unspecific antibodies labelled with Bi-213 could not kill NHL cells. Breaking radio-/chemoresistance in NHL cells using [Bi-213]anti-CD20 depends on caspase activation as demonstrated by complete inhibition of [Bi-213]anti-CD20-induced apoptosis with zVAD.fmk, a specific inhibitor of caspases activation. This suggests that deficient activation of caspases was reversed in radioresistant NHL cells using [Bi-213]anti-CD20. Activation of mitochondria, resulting in caspase-9 activation was restored and downregulation of Bcl-xL and XIAP, death-inhibiting proteins, was found after [Bi-213]anti-CD20 treatment in radio-/chemosensitive and radio-/chemoresistant NHL cells. [Bi-213]anti-CD20 seems to be a promising radioimmunoconjugate to improve therapeutic success by breaking radio- and chemoresistance selectively in CD20-expressing NHL cells via re-activating apoptotic pathways through reversing deficient

  5. NE-SPEC, Ne-213 Liquid Scintillation Detector Fast Neutron Spectra Unfolding

    International Nuclear Information System (INIS)

    1 - Description of problem or function: The NE-SPEC system is composed of three types of programs: - The code to convert the pulse height distributions from counts per channel to counts per light unit. - The code to generate the response matrix. - The unfolding code(s). 2 - Method of solution: Considering the three code types in turn: As the unit of the pulse height distribution must be matched to that of the response matrix, it is necessary to convert from counts per channel to counts per light unit. In this system the light unit used is the Na light unit. Also a new calibration method is used to determine the coefficients of the linear expression that defines the relationship between the channel number and the light unit. This method utilizes the relations between the values of the light unit for the energy of the Compton peak and the corresponding channel number of the gamma ray sources. The response matrix of the NE213 is obtained using Monte Carlo. 47 neutron groups are used in the test run, with cross sections from ENDF/B-IV. The light output data is that evaluated by Verbinski et al. The response matrix is reduced to 34 groups for the unfolding. The pulse height meshes are arranged at equal log spaces from 0.001 to 10.0 Na light units with 60 mesh points per decade. For unfolding, two codes, FERDOS and ITEM-II, which are based on different principles are available, so as to check their results. FERDOS employs a constrained least squares unfolding procedure whilst ITEM-II uses an iterative unfolding method. 3 - Restrictions on the complexity of the problem: Number of data points per unit decade of pulse height intervals - max. 60. Number of decades in the pulse height region: max. 4. Pulse height of initial mesh in Na units: min. 0.001. Number of channels in the measured pulse height distribution: max. 1024. Number of data points of the pulse height distribution: max. 150. Maximum size of response matrix is 55 (neutron energy mesh)*165 (light output mesh)

  6. Treatment of small cell lung cancer with a combination of VP16-213 and cyclophosphamide with cisplatin or radiotherapy

    International Nuclear Information System (INIS)

    Fifty five patients with small cell lung cancer were treated with a VP16-213 combination chemotherapy regimen in two consecutive series. The first series included 24 patients; 10 with limited and 14 with extensive disease were treated with VP16-213, 120 mg/m2 p.o. daily for 5 consecutive days, Cyclophosphamide 600 mg/m2 i.v. and Cisplatin 80 mg/m2 i.v. with hydratation and manitol induced diuresis. The cycle was repeated every 3 weeks. The second series included 31 similar patients, 16 limited, and 15 extensive disease, treated with VP16-213 at the same dose and Cyclophosphamide at 1,200 mg/m2 i.v. also repeated every 3 weeks; after three cycles the patients were treated with radiotherapy to the primary tumor and regional lymph nodes with 4,000 rads in a split course of three weeks interval, followed by the same combination chemotherapy. Response rate was 75% for the first series with 6 of 24 (25%) of complete responses in four limited and two extensive disease and a median survival time of 24 weeks. In the second series of patients there were 26 of 31 (83.8%) responses with 10 of 31 (32%) complete responses in nine limited and one extensive disease and a median survival time of 33 weeks for responders. Duration of response for complete responders was 36.8 weeks for the first series and 51 weeks for the second. Toxicity was mild and indludes nausea and vomitting, myelosupression, alopecia in both series, with one toxic death in the second series. Both regimes are active with a low complete response rate, which was increased in the second series by the addition of radiotherapy, which did not increase overall survival. (orig.)

  7. Therapeutic efficacy and toxicity of {sup 225}Ac-labelled vs. {sup 213}Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Essler, Markus; Gaertner, Florian C.; Blechert, Birgit; Senekowitsch-Schmidtke, Reingard; Seidl, Christof [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Neff, Frauke [Helmholtz Zentrum Muenchen, Institute of Pathology, Neuherberg (Germany); Bruchertseifer, Frank; Morgenstern, Alfred [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany)

    2012-04-15

    Targeted delivery of alpha-particle-emitting radionuclides is a promising novel option in cancer therapy. We generated stable conjugates of the vascular tumour-homing peptide F3 both with {sup 225}Ac and {sup 213}Bi that specifically bind to nucleolin on the surface of proliferating tumour cells. The aim of our study was to determine the therapeutic efficacy of {sup 225}Ac-DOTA-F3 in comparison with that of {sup 213}Bi-DTPA-F3. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were determined via clonogenic assays. The therapeutic efficacy of both constructs was assayed by repeated treatment of mice bearing intraperitoneal MDA-MB-435 xenograft tumours. Therapy was monitored by bioluminescence imaging. Nephrotoxic effects were analysed by histology. ID{sub 50} values of {sup 213}Bi-DTPA-F3 and {sup 225}Ac-DOTA-F3 were 53 kBq/ml and 67 Bq/ml, respectively. The median survival of control mice treated with phosphate-buffered saline was 60 days after intraperitoneal inoculation of 1 x 10{sup 7} MDA-MB-435 cells. Therapy with 6 x 1.85 kBq of {sup 225}Ac-DOTA-F3 or 6 x 1.85 MBq of {sup 213}Bi-DTPA-F3 prolonged median survival to 95 days and 97 days, respectively. While F3 labelled with short-lived {sup 213}Bi (t{sub 1/2} 46 min) reduced the tumour mass at early time-points up to 30 days after treatment, the antitumour effect of {sup 225}Ac-DOTA-F3 (t{sub 1/2} 10 days) increased at later time-points. The difference in the fraction of necrotic cells after treatment with {sup 225}Ac-DOTA-F3 (43%) and with {sup 213}Bi-DTPA-F3 (36%) was not significant. Though histological analysis of kidney samples revealed acute tubular necrosis and tubular oedema in 10-30% of animals after treatment with {sup 225}Ac-DOTA-F3 or {sup 213}Bi-DTPA-F3, protein casts were negligible (2%), indicating only minor damage to the kidney. Therapy with both {sup 225}Ac-DOTA-F3 and {sup 213}Bi-DTPA-F3 increased survival of mice with peritoneal carcinomatosis. Mild renal toxicity of both

  8. THE EFFECTS OF BOGUS TYPHOON AND OBSERVED OCEANIC DATA ON THE ABILITY OF T213L31 TO PREDICT TC TRACK

    Institute of Scientific and Technical Information of China (English)

    MA Su-hong; WANG Jian-jie; WAN Feng

    2007-01-01

    The abilities of typhoon (TC) track prediction by a medium-range forecast model T213L31 at National Meteorological Center are analyzed and its ability to improve its TC forecasts is discussed. The results show that about 57% of the TCs could be predicted by T213L31 but the initial position errors are large.The 43% area without the prediction of TC tracks is concentrated between 13°N and 20°N and east of 120°E and lack of conventional observation data is the main reason for the absence of TC prediction in this area.The adding of bogus TC could improve the ability of TC track prediction when there is no TC vortex in the analysis field, but could only have positive effects on the short-range TC track prediction when there is TC vortex in the T213L31 analysis field.

  9. Anti-CD45 Pretargeted Radioimmunotherapy using Bismuth-213: High Rates of Complete Remission and Long-Term Survival in a Mouse Myeloid Leukemia Xenograft Model

    Energy Technology Data Exchange (ETDEWEB)

    Pagel, John M; Kenoyer, Aimee L; Back, Tom; Hamlin, Donald K; Wilbur, D Scott; Fisher, Darrell R; Park, Steven I; Frayo, Shani; Axtman, Amanda; Orgun, Nural; Orozoco, Johnnie; Shenoi, Jaideep; Lin, Yukang; Gopal, Ajay K; Green, Damian J; Appelbaum, Frederick R; Press, Oliver W

    2011-07-21

    Pretargeted radioimmunotherapy (PRIT) using an anti-CD45 antibody (Ab)-streptavidin (SA) conjugate and DOTA-biotin labeled with β-emitting radionuclides has been explored as a strategy to decrease relapse and toxicity. α-emitting radionuclides exhibit high cytotoxicity coupled with a short path-length, potentially increasing the therapeutic index and making them an attractive alternative to β-emitting radionuclides for patients with Acute Myeloid Leukemia (AML). Accordingly, we have used 213Bi in mice with human leukemia xenografts. Results demonstrated excellent localization of 213Bi-DOTA-biotin to tumors with minimal uptake into normal organs. After 10 minutes, 4.5 ± 1.1% of the injected dose of 213Bi was delivered per gram of tumor. α imaging demonstrated uniform radionuclide distribution within tumor tissue 45 minutes after 213Bi-DOTA-biotin injection. Radiation absorbed doses were similar to those observed using a β-emitting radionuclide (90Y) in the same model. We conducted therapy experiments in a xenograft model using a single-dose of 213Bi-DOTA-biotin given 24 hours after anti-CD45 Ab-SA conjugate. Among mice treated with anti-CD45 Ab-SA conjugate followed by 800 μCi of 213Bi- or 90Y-DOTA-biotin, 80% and 20%, respectively, survived leukemia-free for >100 days with minimal toxicity. These data suggest that anti-CD45 PRIT using an α-emitting radionuclide may be highly effective and minimally toxic for treatment of AML.

  10. Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8,Met(O2)11]-substance P: a pilot trial

    International Nuclear Information System (INIS)

    Functionally critically located gliomas represent a challenging subgroup of intrinsic brain neoplasms. Standard therapeutic recommendations often cannot be applied, because radical treatment and preservation of neurological function are contrary goals. The successful targeting of gliomas with locally injected beta radiation-emitting 90Y-DOTAGA-substance P has been shown previously. However, in critically located tumours, the mean tissue range of 5 mm of 90Y may seriously damage adjacent brain areas. In contrast, the alpha radiation-emitting radionuclide 213Bi with a mean tissue range of 81 μm may have a more favourable toxicity profile. Therefore, we evaluated locally injected 213Bi-DOTA-substance P in patients with critically located gliomas as the primary therapeutic modality. In a pilot study, we included five patients with critically located gliomas (WHO grades II-IV). After diagnosis by biopsy, 213Bi-DOTA-substance P was locally injected, followed by serial SPECT/CT and MR imaging and blood sampling. Besides feasibility and toxicity, the functional outcome was evaluated. Targeted radiopeptide therapy using 213Bi-DOTA-substance P was feasible and tolerated without additional neurological deficit. No local or systemic toxicity was observed. 213Bi-DOTA-substance P showed high retention at the target site. MR imaging was suggestive of radiation-induced necrosis and demarcation of the tumours, which was validated by subsequent resection. This study provides proof of concept that targeted local radiotherapy using 213Bi-DOTA-substance P is feasible and may represent an innovative and effective treatment for critically located gliomas. Primarily non-operable gliomas may become resectable with this treatment, thereby possibly improving the prognosis. (orig.)

  11. Main building complex WWER 440/213 upper range design response spectra for soft soil site conditions (Paks)

    International Nuclear Information System (INIS)

    Within the Benchmark studies parallel investigation were prepared for the main building complex of the WWER-440/213 Paks NPP by several participating institutions. The investigations were based on various mathematical models and procedures but all had the same seismological data as input. The calculation methods as well as software tools were different. This report covers the enveloped response results which were the basis for the benchmark studies and which should be used for upgrading of mechanical and electrical components and systems which will follow. These response spectra which consider a certain conservatism namely neglecting the frequency independence of the stiffness and the cut-off of damping values are named 'Upper Range design Benchmark Response Spectra' for the main building of Paks NPP

  12. Relap5/Mod3.1 analysis of main steam header rupture in VVER- 440/213 NPP

    International Nuclear Information System (INIS)

    The presentation is focused on two main topics. First the applied modelling of PGV-4 steam generator for RELAP5 code are described. The results of steady-state calculation under reference conditions are compared against measured data. The problem of longitudinal subdivision of SG tubes is analysed and evaluated. Secondly, a best-estimate analysis of main steam header (MSH) rupture accident in WWER-440/213 NPP is presented. The low reliability of initiation of ESFAS signal 'MSH Rupture' leads in this accident to big loss of secondary coolant, full depressurization of main steam system, extremely fast cool-down of both secondary and primary system, opening of PRZ SV-bypass valve with later liquid outflow, potential reaching of secondary criticality by failure of HPIS

  13. Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state

    Science.gov (United States)

    Morito, Daisuke; Nishikawa, Kouki; Hoseki, Jun; Kitamura, Akira; Kotani, Yuri; Kiso, Kazumi; Kinjo, Masataka; Fujiyoshi, Yoshinori; Nagata, Kazuhiro

    2014-03-01

    Moyamoya disease is an idiopathic human cerebrovascular disorder that is characterized by progressive stenosis and abnormal collateral vessels. We recently identified mysterin/RNF213 as its first susceptibility gene, which encodes a 591-kDa protein containing enzymatically active P-loop ATPase and ubiquitin ligase domains and is involved in proper vascular development in zebrafish. Here we demonstrate that mysterin further contains two tandem AAA+ ATPase modules and forms huge ring-shaped oligomeric complex. AAA+ ATPases are known to generally mediate various biophysical and mechanical processes with the characteristic ring-shaped structure. Fluorescence correlation spectroscopy and biochemical evaluation suggested that mysterin dynamically changes its oligomeric forms through ATP/ADP binding and hydrolysis cycles. Thus, the moyamoya disease-associated gene product is a unique protein that functions as ubiquitin ligase and AAA+ ATPase, which possibly contributes to vascular development through mechanical processes in the cell.

  14. Relap5/Mod3.1 analysis of main steam header rupture in VVER- 440/213 NPP

    Energy Technology Data Exchange (ETDEWEB)

    Kral, P. [Nuclear Research Inst. Rez (Switzerland)

    1995-12-31

    The presentation is focused on two main topics. First the applied modelling of PGV-4 steam generator for RELAP5 code are described. The results of steady-state calculation under reference conditions are compared against measured data. The problem of longitudinal subdivision of SG tubes is analysed and evaluated. Secondly, a best-estimate analysis of main steam header (MSH) rupture accident in WWER-440/213 NPP is presented. The low reliability of initiation of ESFAS signal `MSH Rupture` leads in this accident to big loss of secondary coolant, full depressurization of main steam system, extremely fast cool-down of both secondary and primary system, opening of PRZ SV-bypass valve with later liquid outflow, potential reaching of secondary criticality by failure of HPIS. 7 refs.

  15. {sup 213}Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience

    Energy Technology Data Exchange (ETDEWEB)

    Kratochwil, C.; Giesel, F.L.; Mier, W.; Haberkorn, U. [University Hospital Heidelberg, Department of Nuclear Medicine, Heidelberg (Germany); Bruchertseifer, F.; Apostolidis, C.; Morgenstern, A. [European Commission, Institute for Transuranium Elements, Karlsruhe (Germany); Boll, R.; Murphy, K. [Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    2014-11-15

    Radiopeptide therapy using a somatostatin analogue labelled with a beta emitter such as {sup 90}Y/{sup 177}Lu-DOTATOC is a new therapeutic option in neuroendocrine cancer. Alternative treatments for patients with refractory disease are rare. Here we report the first-in-human experience with {sup 213}Bi-DOTATOC targeted alpha therapy (TAT) in patients pretreated with beta emitters. Seven patients with progressive advanced neuroendocrine liver metastases refractory to treatment with {sup 90}Y/{sup 177}Lu-DOTATOC were treated with an intraarterial infusion of {sup 213}Bi-DOTATOC, and one patient with bone marrow carcinosis was treated with a systemic infusion of {sup 213}Bi-DOTATOC. Haematological, kidney and endocrine toxicities were assessed according to CTCAE criteria. Radiological response was assessed with contrast-enhanced MRI and {sup 68}Ga-DOTATOC-PET/CT. More than 2 years of follow-up were available in seven patients. The biodistribution of {sup 213}Bi-DOTATOC was evaluable with 440 keV gamma emission scans, and demonstrated specific tumour binding. Enduring responses were observed in all treated patients. Chronic kidney toxicity was moderate. Acute haematotoxicity was even less pronounced than with the preceding beta therapies. TAT can induce remission of tumours refractory to beta radiation with favourable acute and mid-term toxicity at therapeutic effective doses. (orig.)

  16. A novel duplication of chromosome (13)(q14.1q21.3) in a patient with mental retardation and microcephaly

    NARCIS (Netherlands)

    Verhoeven, W.M.A.; Ruiter, E.M.; Egger, J.I.M.; Tuinier, S.; Smeets, D.F.C.M.

    2009-01-01

    A novel duplication of chromosome (13)(q14.1q21.3) in a patient with mental retardation and microcephaly: We report on a mentally retarded female with behavioural problems, microcephaly, mild facial dysmorphisms, short stature and small hands with thin fingers due to a de novo partial duplication wi

  17. A novel duplication of chromosome (13)(q14.1q21.3) in a patient with mental retardation and microcephaly.

    NARCIS (Netherlands)

    Verhoeven, W.; Ruiter, M.; Egger, J.; Tuinier, S.; Smeets, D.F.C.M.

    2009-01-01

    We report on a mentally retarded female with behavioural problems, microcephaly, mild facial dysmorphisms, short stature and small hands with thin fingers due to a de novo partial duplication within the long arm of chromosome 13(q14.1q21.3). She was primarily referred to the outpatient department of

  18. 5 CFR 839.213 - May I make a retirement coverage election if I withdrew all or part of my TSP account after I was...

    Science.gov (United States)

    2010-01-01

    ... of my TSP account after I was corrected to FERS? (a) You may not make a retirement coverage election... after you separated (because your account balance was $3,500 or less), or if you received a financial... if I withdrew all or part of my TSP account after I was corrected to FERS? 839.213 Section...

  19. 213Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience

    International Nuclear Information System (INIS)

    Radiopeptide therapy using a somatostatin analogue labelled with a beta emitter such as 90Y/177Lu-DOTATOC is a new therapeutic option in neuroendocrine cancer. Alternative treatments for patients with refractory disease are rare. Here we report the first-in-human experience with 213Bi-DOTATOC targeted alpha therapy (TAT) in patients pretreated with beta emitters. Seven patients with progressive advanced neuroendocrine liver metastases refractory to treatment with 90Y/177Lu-DOTATOC were treated with an intraarterial infusion of 213Bi-DOTATOC, and one patient with bone marrow carcinosis was treated with a systemic infusion of 213Bi-DOTATOC. Haematological, kidney and endocrine toxicities were assessed according to CTCAE criteria. Radiological response was assessed with contrast-enhanced MRI and 68Ga-DOTATOC-PET/CT. More than 2 years of follow-up were available in seven patients. The biodistribution of 213Bi-DOTATOC was evaluable with 440 keV gamma emission scans, and demonstrated specific tumour binding. Enduring responses were observed in all treated patients. Chronic kidney toxicity was moderate. Acute haematotoxicity was even less pronounced than with the preceding beta therapies. TAT can induce remission of tumours refractory to beta radiation with favourable acute and mid-term toxicity at therapeutic effective doses. (orig.)

  20. Enhanced efficacy of combined {sup 213}Bi-DTPA-F3 and paclitaxel therapy of peritoneal carcinomatosis is mediated by enhanced induction of apoptosis and G2/M phase arrest

    Energy Technology Data Exchange (ETDEWEB)

    Vallon, Mario; Seidl, Christof; Blechert, Birgit; Li, Zhoulei; Gaertner, Florian C.; Senekowitsch-Schmidtke, Reingard; Essler, Markus [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Gilbertz, Klaus-Peter [German Armed Forces, Institute of Radiobiology, Munich (Germany); Baumgart, Anja [Technische Universitaet Muenchen, III. Medical Department, Munich (Germany); Aichler, Michaela; Feuchtinger, Annette; Walch, Axel K. [Helmholtz Zentrum Muenchen, Institute of Pathology, Neuherberg (Germany); Bruchertseifer, Frank; Morgenstern, Alfred [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany)

    2012-12-15

    Targeted therapy with {alpha}-particle emitting radionuclides is a promising new option in cancer therapy. Stable conjugates of the vascular tumour-homing peptide F3 with the {alpha}-emitter {sup 213}Bi specifically target tumour cells. The aim of our study was to determine efficacy of combined {sup 213}Bi-diethylenetriaminepentaacetic acid (DTPA)-F3 and paclitaxel treatment compared to treatment with either {sup 213}Bi-DTPA-F3 or paclitaxel both in vitro and in vivo. Cytotoxicity of treatment with {sup 213}Bi-DTPA-F3 and paclitaxel, alone or in combination, was assayed towards OVCAR-3 cells using the alamarBlue assay, the clonogenic assay and flow cytometric analyses of the mode of cell death and cell cycle arrest. Therapeutic efficacy of the different treatment options was assayed after repeated treatment of mice bearing intraperitoneal OVCAR-3 xenograft tumours. Therapy monitoring was performed by bioluminescence imaging and histopathologic analysis. Treatment of OVCAR-3 cells in vitro with combined {sup 213}Bi-DTPA-F3 and paclitaxel resulted in enhanced cytotoxicity, induction of apoptosis and G2/M phase arrest compared to treatment with either {sup 213}Bi-DTPA-F3 or paclitaxel. Accordingly, i.p. xenograft OVCAR-3 tumours showed the best response following repeated (six times) combined therapy with {sup 213}Bi-DTPA-F3 (1.85 MBq) and paclitaxel (120 {mu}g) as demonstrated by bioluminescence imaging and histopathologic investigation of tumour spread on the mesentery of the small and large intestine. Moreover, mean survival of xenograft mice that received combined therapy with {sup 213}Bi-DTPA-F3 and paclitaxel was significantly superior to mice treated with either {sup 213}Bi-DTPA-F3 or paclitaxel alone. Combined treatment with {sup 213}Bi-DTPA-F3 and paclitaxel significantly increased mean survival of mice with peritoneal carcinomatosis of ovarian origin, thus favouring future therapeutic application. (orig.)

  1. Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.

    Directory of Open Access Journals (Sweden)

    Elizabeth A Rodkey

    Full Text Available β-Lactamases are the major reason β-lactam resistance is seen in Gram-negative bacteria. To combat this resistance mechanism, β-lactamase inhibitors are currently being developed. Presently, there are only three that are in clinical use (clavulanate, sulbactam and tazobactam. In order to address this important medical need, we explored a new inhibition strategy that takes advantage of a long-lived inhibitory trans-enamine intermediate. SA2-13 was previously synthesized and shown to have a lower k(react than tazobactam. We investigated here the importance of the carboxyl linker length and composition by synthesizing three analogs of SA2-13 (PSR-4-157, PSR-4-155, and PSR-3-226. All SA2-13 analogs yielded higher turnover numbers and k(react compared to SA2-13. We next demonstrated using protein crystallography that increasing the linker length by one carbon allowed for better capture of a trans-enamine intermediate; in contrast, this trans-enamine intermediate did not occur when the C2 linker length was decreased by one carbon. If the linker was altered by both shortening it and changing the carboxyl moiety into a neutral amide moiety, the stable trans-enamine intermediate in wt SHV-1 did not form; this intermediate could only be observed when a deacylation deficient E166A variant was studied. We subsequently studied SA2-13 against a relatively recently discovered inhibitor-resistant (IR variant of SHV-1, SHV K234R. Despite the alteration in the mechanism of resistance due to the K→R change in this variant, SA2-13 was effective at inhibiting this IR enzyme and formed a trans-enamine inhibitory intermediate similar to the intermediate seen in the wt SHV-1 structure. Taken together, our data reveals that the C2 side chain linker length and composition profoundly affect the formation of the trans-enamine intermediate of penam sulfones. We also show that the design of SA2-13 derivatives offers promise against IR SHV β-lactamases that possess the

  2. Somatostatin-receptor-targeted {alpha}-emitting {sup 213}Bi is therapeutically more effective than {beta}{sup -}-emitting {sup 177}Lu in human pancreatic adenocarcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, Tapan K. [Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131-0001 (United States); Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, NM 87131 (United States); Norenberg, Jeffrey P. [Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131-0001 (United States)]. E-mail: jpnoren@unm.edu; Anderson, Tamara L. [Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131-0001 (United States); Prossnitz, Eric R. [Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, NM 87131 (United States); Stabin, Michael G. [Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232 (United States); Atcher, Robert W. [Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico, Albuquerque, NM 87131-0001 (United States); Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2007-02-15

    Introduction: Advance clinical cancer therapy studies of patients treated with somatostatin receptor (sstr)-targeted [DOTA{sup 0}-Tyr{sup 3}]octreotide (DOTATOC) labeled with low-linear-energy-transfer (LET) {beta}{sup -}-emitters have shown overall response rates in the range of 15-33%. In order to improve outcomes, we sought to compare the therapeutic effectiveness of sstr-targeted high-LET {alpha}-emitting {sup 213}Bi to that of low-LET {beta}{sup -}-emitting {sup 177}Lu by determining relative biological effectiveness (RBE) using the external {gamma}-beam of {sup 137}Cs as reference radiation. Methods: Sstr-expressing human pancreatic adenocarcinoma Capan-2 cells and A549 control cells were used for this study. The effects of different radiation doses of {sup 213}Bi and {sup 177}Lu labeled to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid and sstr-targeted DOTATOC were investigated with a clonogenic cell survival assay. Apoptosis was measured using the Cell Death Detection ELISA{sup PLUS} 10x kit. Results: Using equimolar DOTATOC treatment with concurrent irradiation with a {sup 137}Cs source as reference radiation, the calculated RBE of [{sup 213}Bi]DOTATOC was 3.4, as compared to 1.0 for [{sup 177}Lu]DOTATOC. As measured in terms of absorbance units, [{sup 213}Bi]DOTATOC caused a 2.3-fold-greater release of apoptosis-specific mononucleosomes and oligonucleosomes than [{sup 177}Lu]DOTATOC at the final treatment time of 96 h (P<.001) in sstr-expressing Capan-2 cells. Conclusions: In conclusion, at the same absorbed dose, [{sup 213}Bi]DOTATOC is therapeutically more effective in decreasing survival than is [{sup 177}Lu]DOTATOC in human pancreatic adenocarcinoma cells due to its comparatively higher RBE.

  3. Comparative analysis of CD138 antigen targeting for the treatment of multiple myeloma with bismuth-213 and Melphalan chemotherapy

    International Nuclear Information System (INIS)

    Full text of publication follows. Aim: multiple myeloma (MM) is a B-cell malignancy of terminally differentiated plasma cells within the bone marrow, with the presence of a monoclonal immunoglobulin in serum and/or urine and development of osteolytic bone lesions in human. Despite intense research to develop new treatments, cure is almost never achieved. Alpha-radioimmunotherapy (RIT) has been shown to be effective in vivo in a multiple myeloma model and seems particularly suited for disseminated tumour cells or small clusters of tumour cells. CD138 (Syndecan-1) is found mainly in epithelial cells, but has been shown to be expressed by most myeloma cells, both in human and in mouse. In order to define where alpha RIT stands in MM treatment, the aim of this study was to compare Melphalan, MM standard treatment, with alpha RIT using a bismuth-213-labelled anti-mouse CD138 rat antibody in a syngeneic mouse MM model. Material and Methods: C57BL/KaLwRij mice were grafted with 106 5T33 cells (murine myeloma cells). Luciferase transfected 5T33 were used for in vivo localization of the cells during the course of disease. The first step of the study was to assess the dose-response of Melphalan (100, 200 et 300 μg/mouse), 21 days after engraftment. The second step consisted in therapeutic association: Melphalan followed by RIT at d22 et d25 after engraftment. Toxicity (animal weight, blood cell counts) and treatment efficacy were studied in animals receiving no treatment, injected with Melphalan alone (200 μg), RIT alone at d22 and d25 (3.7 MBq of 213Bi-anti-CD138) and Melphalan combined with alpha RIT. Results: fifty percent of untreated mice died by d64 after MM engraftment. In mice treated with Melphalan alone, only the 200 μg dose improved median survival. No animal was cured after Melphalan treatment whereas 60% of the mice survived with RIT alone at d22 after tumour engraftment. However, the therapeutic window seems to be narrow, indeed no effect was observed with

  4. Study on the scenic design of tunnel portals on Langchuan road of the 213th national highway%国道213线郎川公路隧道洞口景观设计方法探讨

    Institute of Scientific and Technical Information of China (English)

    韩斌; 潘荣伟

    2006-01-01

    隧道洞口是隧道的门户,在隧道工程中有着很重要的地位.随着社会对土木工程结构物(隧道、桥梁等)的要求越来越高,使得景观设计成为隧道结构物设计的重要内容之一.目前,景观设计的概念虽已引入到隧道洞口设计当中,但有些隧道洞门仍采用结构单一,形式呆板的洞门.本文以国道213线郎川公路的四座隧道为例,探讨隧道洞口景观设计的方法,以期能为隧道洞口景观设计提供参考.

  5. 213个遗传性耳聋家庭的产前诊断和生育指导%Prenatal genetic test and clinical guidance for 213 hereditary deaf families

    Institute of Scientific and Technical Information of China (English)

    韩明昱; 戴朴; 卢彦平; 边旭明; 汪龙霞; 黄莎莎; 王国建; 王毅; 康东洋; 张昕

    2012-01-01

    Objective To summarize the workflow,strategy and experience of prenatal genetic test for deafness based on the 6-year clinical practice.Methods There were 213 famihes who received prenatal test from 2005 to 2011.Among the 213 families,205 families had had one deaf child,including 204 couples with normal hearing and one couple of the deaf husband and normal wife,8 families including 6 couples with normal hearing and 2 deaf couples,had no child before test. Genomic and mitochondrial DNA of each subject was extracted from whole blood.The etiology and recurrent risks in 212 families were confirmed by means of the genetic test of GJB2,SLC26A4 and mtDNA 12sRNA,but one family carried POU3F4 c.647G > A heterozygous mutation causing X-linked hereditary hearing impairment confirmed by pedigree study.The prenatal test was carried out during the pregnancy of all mothers from 11 to 30 weeks,and the following genetic information and counseling were supplied based on the results.Results The recurrent risk was 25%in 209 families,including 204 families with one deaf child and 5 families without child,among which all couples were GJB2 or SLC26A4 mutation carriers and deaf children were caused by homozygous or compound GJB2/SLC26A4 mutations; The recurrent risk was 50% in 3 families,the father and his child in one family had compound SLC26A4 mutations and the mother with heterozygous SLC26A4 mutation,the wife had POU3F4 c.647G > A heterozygous mutation in another one family,and the husband with compound SLC26A4 mutations and the wife with mtDNA A1555G mutation and heterozygous SLC26A4 mutation simultaneously happened in the rest one family; The recurrent risk was 100% in one family of the deaf couple who were both found to carry homozygous or compound GJB2 mutations,and the deaf wife got pregnant by artificial insemination with the sperm from the local Human Sperm Bank.226 times of prenatal test were applied in all 213 families that 11 families of them received prenatal

  6. [Determination of 213 pesticide residues in milk and milk power by gas chromatography-triple quadrupole tandem mass spectrometry].

    Science.gov (United States)

    Wang, Jing; Ai, Lianfeng; Ma, Yusong; Zhang, Haichao; Li, Wei; Yu, Meng

    2015-11-01

    On the basis of the optimization of solid phase extraction adsorbent, eluting solvent types and amounts, a gas chromatography-triple quadrupole tandem mass spectrometry (GC-MS/MS) method was established for the determination of 213 pesticide residues in milk and milk power. The samples were extracted by acetonitrile, cleaned-up with an ENVI-Carb/NH2 solid-phase extractant, and determined by GC-MS/MS using external standard method. The linear ranges were from 10 to 1 000 μg/L for 197 pesticides, from 50 to 1 000 μg/L for the other 16 pesticides with the correlation coefficients higher than 0.99. The limits of detection (LODs, S/N = 3) varied over the range of 0.03 to 7.59 μg/kg, and limits of quantification (LOQs, S/N = 10) ranged from 0.10 to 21.94 μg/kg. The average recoveries in different matrices were in the range of 66.9% - 120.1% with the relative standard deviations (RSDs) of 1.23% - 17.6%. This method is simple, rapid, sensitive and reliable for meeting the requirements for the simultaneous identification and quantification of the multi-residues in milk and milk power. PMID:26939364

  7. [Determination of 213 pesticide residues in milk and milk power by gas chromatography-triple quadrupole tandem mass spectrometry].

    Science.gov (United States)

    Wang, Jing; Ai, Lianfeng; Ma, Yusong; Zhang, Haichao; Li, Wei; Yu, Meng

    2015-11-01

    On the basis of the optimization of solid phase extraction adsorbent, eluting solvent types and amounts, a gas chromatography-triple quadrupole tandem mass spectrometry (GC-MS/MS) method was established for the determination of 213 pesticide residues in milk and milk power. The samples were extracted by acetonitrile, cleaned-up with an ENVI-Carb/NH2 solid-phase extractant, and determined by GC-MS/MS using external standard method. The linear ranges were from 10 to 1 000 μg/L for 197 pesticides, from 50 to 1 000 μg/L for the other 16 pesticides with the correlation coefficients higher than 0.99. The limits of detection (LODs, S/N = 3) varied over the range of 0.03 to 7.59 μg/kg, and limits of quantification (LOQs, S/N = 10) ranged from 0.10 to 21.94 μg/kg. The average recoveries in different matrices were in the range of 66.9% - 120.1% with the relative standard deviations (RSDs) of 1.23% - 17.6%. This method is simple, rapid, sensitive and reliable for meeting the requirements for the simultaneous identification and quantification of the multi-residues in milk and milk power.

  8. Peroxidase-catalyzed metabolism of etoposide (VP-16-213) and covalent binding of reactive intermediates to cellular macromolecules

    International Nuclear Information System (INIS)

    The horseradish peroxidase- and prostaglandin synthetase-catalyzed oxidative metabolism of the highly active anticancer drug, etoposide (VP-16-213), has been studied in vitro. This oxidation of VP-16 resulted in the formation of VP-16 quinone, an aromatic VP-16 derivative and the corresponding aromatic VP-16 quinone. This oxidative metabolism of VP-16 also resulted in the formation of reactive species that covalently bound to exogenously added DNA and heat-inactivated microsomal proteins. The peroxidase-catalyzed binding was time dependent and required the presence of cofactors (hydrogen peroxide or arachidonic acid). The prostaglandin synthetase/arachidonic acid-catalyzed metabolism and binding of VP-16 were inhibited by indomethacin, an inhibitor of the cyclooxygenase, and were shown to involve the peroxidative arm of prostaglandin synthetase. Our studies show that the protein covalent binding species were formed as a result of O-demethylation of the drug as shown by the loss of specifically labeled (O-14CH3) radioactivity from O-methoxy group and by incubating proteins with VP-16 quinones. In contrast, the covalent binding intermediates for DNA appeared to be different and VP-16-derived quinone methides are suggested as DNA binding species. Co-oxidation of VP-16 and the related drug, VM-26, during prostaglandin biosynthesis may be an important pathway for the metabolism of these agents and may play a role in their cytotoxic properties

  9. Clinical Observation on Termination of Early Pregnancy of 213 Cases after Caesarian Section with Repeated Use of Mifepristone and Misoprostol

    Institute of Scientific and Technical Information of China (English)

    高佩佩; 汪平

    1999-01-01

    Objective To investigate the efficacy and safety in women after caesarian section for termination of early pregnancies by treatment, or repeated treatment with mifepristone and misoprostot.Subjects and Methods A total of 213 pregnant women with amenorrhea of 34-69d after caesarian section who asked for medical abortion were recruited,including 63 cases undergoing their second medical abortion.A total amount of mi feprisstone of 150 mg given in separate doses(25 mg×4 and 50 mg at the first time)was administered orally within 3d, followed by misoprostot of 0.6 mg orally in the morning of d 3.Results The complete abortion rate was 92.5%,incomplete abortion was 4.7% and failure was 2.8%.Conclusion The sequential use of mifepristone and misoprostol could be successfully and repeatedly used for induced abortion in those women with a caesarian section histo-ry.Its efficacy was similar to that for ordinary population.Its safety and effec-tiveness were satisfactory.

  10. Measurements of high energy neutrons penetrated through iron shields using the Self-TOF detector and an NE213 organic liquid scintillator

    CERN Document Server

    Sasaki, M; Nunomiya, T; Nakamura, T; Fukumura, A; Takada, M

    2002-01-01

    Neutron energy spectra penetrated through iron shields were measured using the Self-TOF detector and an NE213 organic liquid scintillator which have been newly developed by our group at the Heavy-Ion Medical Accelerator in Chiba (HIMAC) of National Institute of Radiological Sciences (NIRS), Japan. Neutrons were generated by bombarding 400 MeV/nucleon C ion on a thick (stopping-length) copper target. The neutron spectra in the energy range from 20 to 800 MeV were obtained through the FORIST unfolding code with their response functions and compared with the MCNPX calculations combined with the LA150 cross section library. The neutron fluence measured by the NE213 detector was simulated by the track length estimator in the MCNPX, and evaluated the contribution of the room-scattered neutrons. The calculations are in fairly good agreement with the measurements. Neutron fluence attenuation lengths were obtained from the experimental results and the calculation.

  11. Single-dose anti-CD138 radioimmunotherapy: bismuth-213 is more efficient than lutetium-177 for treatment of multiple myeloma in a preclinical model

    OpenAIRE

    Fichou, Nolwenn; Gouard, Sébastien; Maurel, Catherine; Barbet, Jacques; Ferrer, Ludovic; Morgenstern, Alfred; Bruchertseifer, Frank; Faivre-Chauvet, Alain; Bigot-Corbel, Edith; Davodeau, François; Gaschet, Joëlle; Chérel, Michel

    2015-01-01

    Objectives Radioimmunotherapy (RIT) has emerged as a potential treatment option for multiple myeloma (MM). In humans, a dosimetry study recently showed the relevance of RIT using an antibody targeting the CD138 antigen. The therapeutic efficacy of RIT using an anti-CD138 antibody coupled to 213Bi, an α-emitter, was also demonstrated in a preclinical MM model. Since then, RIT with β-emitters has shown efficacy in treating hematologic cancer. In this paper, we investigate the therapeutic eff...

  12. Preclinical evaluation of NETA-based bifunctional ligand for radioimmunotherapy applications using 212Bi and 213Bi: Radiolabeling, serum stability, and biodistribution and tumor uptake studies

    International Nuclear Information System (INIS)

    Introduction: Despite the great potential of targeted α-radioimmunotherapy (RIT) as demonstrated by pre-clinical and clinical trials, limited progress has been made on the improvement of chelation chemistry for 212Bi and 213Bi. A new bifunctional ligand 3p-C-NETA was evaluated for targeted α RIT using 212Bi and 213Bi. Methods: Radiolabeling of 3p-C-NETA with 205/6Bi, a surrogate of 212Bi and 213Bi, was evaluated at pH 5.5 and room temperature. In vitro stability of the 205/6Bi-3p-C-NETA-trastuzumab conjugate was evaluated using human serum (pH 7, 37 °C). Immunoreactivity and specific activity of the 205/6Bi-3p-C-NETA-trastuzumab conjugate were measured. An in vivo biodistribution study was performed to evaluate the in vivo stability and tumor targeting properties of the 205/6Bi-3p-C-NETA-trastuzumab conjugate in athymic mice bearing subcutaneous LS174T tumor xenografts. Result: The 3p-C-NETA-trastuzumab conjugate was extremely rapid in complexing with 205/6Bi, and the corresponding 205/6Bi-3p-C-NETA-trastuzumab was stable in human serum. 205/6Bi-3p-C-NETA-trastuzumab was prepared with a high specific activity and retained immunoreactivity. 205/6Bi-3p-C-NETA-trastuzumab conjugate displayed excellent in vivo stability and targeting as evidenced by low normal organ and high tumor uptake. Conclusion: The results of the in vitro and in vivo studies indicate that 3p-C-NETA is a promising chelator for RIT applications using 212Bi and 213Bi. Further detailed in vivo evaluations of 3p-C-NETA for targeted α RIT are warranted

  13. Synthese, elektrochemische Eigenschaften und Struktur von Metallkomplexen mit 2,1,3-Benzochalkogenadiazol-Liganden und spektroelektrochemische Untersuchungen ausgewählter Zweikernkomplexe

    OpenAIRE

    Plebst, Sebastian

    2015-01-01

    Kapitel 2 und 3 dieser Dissertation beschäftigen sich mit den Koordinationseigenschaften von 2,1,3 Benzochalkogenadiazol Liganden (BCD) (Kap. 2) in Verbindung mit Wolfram und Rheniumkomplexfragmenten sowie mit dem Di Benzochalkogenadiazol System des Bis ([1,2,5]thiadiazolo[2,3 c:5,6c‘]) 1,4 benzochinon (BTDB) und seinen Rheniumcarbonylkomplexen (Kap. 3). Neben der strukturellen und rechnerischen Analyse der Komplexe 1 und 2 konnten erstmalig spektroelektrochemische Messungen im UV/Vis Be...

  14. Preparation of 2'-13C-L-Histidine Starting from 13C-Thiocyanate: Synthetic Access to Any Site-Directed Stable Isotope Enriched L-Histidine

    OpenAIRE

    Sarra Talab; Kamal Khalifa Taha; Johan Lugtenburg

    2014-01-01

    1-Benzyl-2-(methylthio)-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin). Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethyl-imidazolium chloride. This compound is converted under mild O’Donnell conditions into the corresponding L-histidine derivative. After deprotection L-histidine is obtained in good yield and 99% enantiomeric excess. 2'-13C-L-Histidine has been obtai...

  15. Split hand/split foot malformation, deafness, and mental retardation with a complex cytogenetic rearrangement involving 7q21.3.

    OpenAIRE

    Ignatius, J.; Knuutila, S; Scherer, S W; Trask, B; Kere, J

    1996-01-01

    Split hand/split foot malformation (SHSF) has been described in several patients associated with cytogenetically visible rearrangements involving chromosome 7q. Characterisation of these patients has led to localisation of an autosomal dominant form of SHSF to 7q21-22; the locus has been designated SHFM1. We describe a patient with a complex, apparently balanced cytogenetic rearrangement, including a translocation breakpoint at 7q21.3 near the DSS1 gene. In addition to ectrodactyly of all fou...

  16. Crystallization and initial crystallographic analysis of the Streptococcus parasanguinis FW213 Fap1-­NRα adhesive domain at pH 5.0

    OpenAIRE

    Garnett, James A; Ramboarina, Stéphanie; Lee, Wei-chao; Tagliaferri, Camille; Wu, Wilfred; MATTHEWS, STEPHEN

    2011-01-01

    The adhesin fimbriae-associated protein 1 (Fap1) is a surface protein of Streptococcus parasanguinis FW213 and plays a major role in the formation of dental plaque in humans. Here, the adhesive domain Fap1-NRα, which is activated by acidic pH, has been crystallized at pH 5.0 and diffraction data have been collected to 3.0 Å resolution.

  17. Non-invasive visualisation of the development of peritoneal carcinomatosis and tumour regression after 213Bi-radioimmunotherapy using bioluminescence imaging

    International Nuclear Information System (INIS)

    Non-invasive imaging of tumour development remains a challenge, especially for tumours in the intraperitoneal cavity. Therefore, the aim of this study was the visualisation of both the development of peritoneal carcinomatosis and tumour regression after radioimmunotherapy with tumour-specific 213Bi-Immunoconjugates, via in vivo bioluminescence imaging of firefly luciferase-transfected cells. Human diffuse-type gastric cancer cells expressing mutant d9-E-cadherin were stably transfected with firefly luciferase (HSC45-M2-luc). For bioluminescence imaging, nude mice were inoculated intraperitoneally with 1 x 107 HSC45-M2-luc cells. On days 4 and 8 after tumour cell inoculation, imaging was performed following D-luciferin injection using a cooled CCD camera with an image intensifier unit. For therapy, mice were injected with 2.7 MBq 213Bi-d9MAb targeting d9-E-cadherin on day 8 after tumour cell inoculation. Bioluminescence images were taken every 4 days to monitor tumour development. After i.p. inoculation of HSC45-M2-luc cells into nude mice, development as well as localisation of peritoneal carcinomatosis could be visualised using bioluminescence imaging. Following 213Bi-d9MAb therapy on day 8 after intraperitoneal inoculation of HSC45-M2-luc cells, small tumour nodules were totally eliminated and larger nodules showed a clear reduction in size on day 12 after tumour cell inoculation. Subsequently a recurrence of tumour mass was observed, starting from the remaining tumour spots. By measuring the mean grey level intensity, tumour development over time could be demonstrated. Non-invasive bioluminescence imaging permits visualisation of the development of peritoneal carcinomatosis, localisation of tumour in the intraperitoneal cavity and evaluation of therapeutic success after 213Bi-d9MAb treatment. (orig.)

  18. Experience from operation of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia). Report of the IAEA technical co-operation project RER/9/004 on evaluation of safety aspects of WWER-440 model 213 nuclear power plants

    International Nuclear Information System (INIS)

    This TECDOC provides a comprehensive review of the operational experience with WWER-440/213 plants. It is hoped that it will be useful to anyone working in the field of WWER safety, and in particular to experts planning, executing or reviewing studies related to the subject. Refs, figs and tabs

  19. Experimental design verification of WWER-440 model 213 nuclear power plants. Reference plant: Bohunice V2 (Slovakia). Report of the IAEA technical co-operation project RER/9/004 on evaluation of safety aspects of WWER-440 model 213 nuclear power plants

    International Nuclear Information System (INIS)

    This publication addresses the experimental research supporting the design of WWER-440 model 213 plants. it is hoped that the material presented will be useful for experts working in the field of WWER safety, and in particular to those planning, executing or reviewing studies related to the subject. Refs, figs and tabs

  20. MR-guided radiofrequency ablation using a wide-bore 1.5-T MR system: clinical results of 213 treated liver lesions

    International Nuclear Information System (INIS)

    To evaluate the technical effectiveness, technical success and patient safety of MR-guided radiofrequency (RF) ablation of liver malignancies using a wide-bore 1.5-T MR system. In 110 patients, 56 primary liver lesions and 157 liver metastases were treated in 157 sessions using percutaneous RF ablation. Mean lesion diameter was 20 mm (range 4-54 mm). All planning, procedural and post-interventional control MR investigations were carried out using a wide-bore 1.5-T MR system. Technical success was assessed by a contrast-enhanced MR liver examination immediately after the intervention. Technique effectiveness was assessed by dynamic hepatic MR study 1 month post ablation; mean follow-up period was 24.2 months (range 5-44). Technical success and technique effectiveness were achieved in 210/213 lesions (98.6 %). In 18/210 lesions (8.6 %), local tumour progression occurred 4-28 months after therapy. Seven of these 18 lesions were treated in a second session achieving complete ablation, 6 other lesions were referred to surgery. Overall RF effectiveness rate was 199/213 (93.4 %); overall therapy success (including surgery) was 205/213 (96.2 %). Two major complications (1.3 %) (bleeding and infected biloma) and 14 (8.9 %) minor complications occurred subsequent to 157 interventions. Wide-bore MR-guided RF ablation is a safe and effective treatment option for liver lesions. (orig.)

  1. Multiwavelength monitoring and X-ray brightening of Be X-ray binary PSR J2032+4127/MT91 213 on its approach to periastron

    CERN Document Server

    Ho, Wynn C G; Lyne, Andrew G; Stappers, Ben W; Coe, Malcolm J; Halpern, Jules P; Johnson, Tyrel J; Steele, Iain A

    2016-01-01

    The radio and gamma-ray pulsar PSR J2032+4127 was recently found to be in a decades-long orbit with the Be star MT91 213, with the pulsar moving rapidly toward periastron. This binary shares many similar characteristics with the previously unique binary system PSR B1259-63/LS 2883. Here we describe radio, X-ray, and optical monitoring of PSR J2032+4127/MT91 213. Our extended orbital phase coverage in radio, supplemented with Fermi gamma-ray data, allows us to update and refine the orbital period to 45-50 yr and time of periastron passage to November 2017. We analyze archival and recent Chandra and Swift observations and show that PSR J2032+4127/MT91 213 is now brighter in X-rays by a factor of ~70 since 2002 and ~20 since 2010. While the pulsar is still far from periastron, this increase in X-rays is possibly due to collisions between pulsar and Be star winds. Optical observations of the Halpha emission line of the Be star suggest that the size of its circumstellar disk may be varying by ~2 over timescales as...

  2. Methemoglobin-producing effect and its role in the mechanism of action of some radioprotective agents in the benzo-2,1,3-thiadiazole class. [Mice, dogs, gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Vladimirov, V.G.; Chigareva, N.G.; Belen' kaya, I.A.; Strel' nikov, Yu.E.

    1977-01-01

    A study was made of some derivatives of benzo-2,1,3-thiadiazole with regard to their capacity to form methemoglobin in blood. It was demonstrated that, 30 min after intraperitoneal administration of radioprotective doses of such agents to mice, the blood methemoglobin level does not exceed 5 percent. With administration to mice of 4-aminobenzo-2,1,3-thiadiazole in a toxic dose 14 percent methemoglobin is produced in blood. In dogs, almost 50 percent methemoglobin is formed in blood after oral intake of 4-aminobenzo-2,1,3-thiadiazole; this is a level that can provide for the radioprotective action of this compound. Using agents that prevent oxidation of hemoglobin to methemoglobin (2-methoxy-9-phenazine sulfate and isonicotinic acid hydrazide), it was demonstrated that the methemoglobin formed in mouse blood does not play a leading role in manifestation of the radioprotective action and toxic properties of 4-aminobenzo-2,1,3-thiadiazole.

  3. Sulfotransferase SULT1A1 Arg213His polymorphism with cancer risk: a meta-analysis of 53 case-control studies.

    Directory of Open Access Journals (Sweden)

    Juanjuan Xiao

    Full Text Available BACKGROUND: The SULT1A1 Arg213His (rs9282861 polymorphism is reported to be associated with many kinds of cancer risk. However, the findings are conflicting. For better understanding this SNP site and cancer risk, we summarized available data and performed this meta-analysis. METHODS: Data were collected from the following electronic databases: PubMed, Web of Knowledge and CNKI. The association was assessed by odd ratio (OR and the corresponding 95% confidence interval (95% CI. RESULTS: A total of 53 studies including 16733 cancer patients and 23334 controls based on the search criteria were analyzed. Overall, we found SULT1A1 Arg213His polymorphism can increase cancer risk under heterozygous (OR  1.09, 95% CI = 1.01-1.18, P = 0.040, dominant (OR = 1.10, 95% CI = 1.01-1.19, P = 0.021 and allelic (OR = 1.08, 95% CI = 1.02-1.16, P = 0.015 models. In subgroup analyses, significant associations were observed in upper aero digestive tract (UADT cancer (heterozygous model: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; dominant model: OR = 1.63, 95% CI = 1.13-2.35, P = 0.009; allelic model: OR = 1.52, 95% CI = 1.10-2.11, P = 0.012 and Indians (recessive model: OR = 1.93, 95% CI = 1.22-3.07, P = 0.005 subgroups. Hospital based study also showed marginally significant association. In the breast cancer subgroup, ethnicity and publication year revealed by meta-regression analysis and one study found by sensitivity analysis were the main sources of heterogeneity. The association between SULT1A1 Arg213His and breast cancer risk was not significant. No publication bias was detected. CONCLUSIONS: The present meta-analysis suggests that SULT1A1 Arg213His polymorphism plays an important role in carcinogenesis, which may be a genetic factor affecting individual susceptibility to UADT cancer. SULT1A1 Arg213His didn't show any association with breast cancer, but the possible risk in Asian population needs further investigation.

  4. Chemoimmunotherapy of small cell bronchogenic carcinoma with VP-16-213, ifosfamide, vincristine, adriamycin, and Corynebacterium parvum

    Energy Technology Data Exchange (ETDEWEB)

    Valdivieso, M.; Tenczynski, T.F.; Rodriguez, V.; Burgess, M.A.; Mountain, C.F.; Barkley, H.T. Jr.; Hersh, E.M.; Bodey, G.P.

    1981-07-15

    Thirty-five consecutive patients with small cell bronchogenic carcinoma (SCBC) received chemoimmunotherapy with VP-16-213, Ifosfamide, vincristine, Adriamycin, and Corynebacterium parvum. Of 33 evaluable patients, 26 (79%) responded with complete (55%) or partial (24%) remissions. Complete remissions were more common among patients with limited disease (11/14 patients, 79%) compared with those with extensive disease (7/19 patients, 37%) and among patients (11/14 patients, 79%) compared with those with extensive disease (7/19 patients, 37%) and among patients who were ambulatory prior to therapy (16/25 patients, 64%) compared with those who were nonambulatory (2/8 patients, 25%). Myelosuppression consisted primarily of neutropenia. Eight percent of the treatment courses in 29% of the patients were associated with hematuria and/or documented episodes of infection during neutropenia. There were three deaths possibly related to treatment, in two of which there was no evidence of disease at post-mortem examination. Six patients relapsed in the central nervous system (CNS). In four instances, CNS relapse was the only site of tumor progression. Central nervous system relapse was more common among evaluable patients who did not receive prophylactic brain irradiation (5/17 patients, 29%, vs. 1/15 patients, 7%; P . 0.23). The median survival duration for all patients was 63 weeks, being slightly longer for patients with limited disease than for those with extensive disease (70.9 weeks vs. 56 weeks; P . 0.18). This was also true for patients who achieved complete rather than partial remissions (71 weeks vs. 50 weeks; P . 0.09). Patients receiving prophylactic brain irradiation experienced longer survival (100.8 weeks vs. 48 weeks; P . 0.01).

  5. Dietary and nutritional status of 213 Han nationality pregnant women in Urumqi%乌鲁木齐市213名汉族孕妇膳食营养状况调查

    Institute of Scientific and Technical Information of China (English)

    王静; 吐尔逊江・买买提明; 马晶; 王晓军

    2015-01-01

    Objective To understand the dietary nutrition and nutrients of Han nationality pregnant women in Urumqi, so as to improve and enhance the nutritional status of them.Methods Totally 213 Han nationality pregnant women were randomly chosen in Maternal and Child Health Care Center of Xinjiang Uygur Autonomous Region for the survey, and questionnaires were used to investigate 24 hour dietary.The data obtained were compared with DRIs for Chinese population.Results Dietary structure of pregnant women was unreasonable.Although the intake of vegetable and fruit reached the RNIs issued by Chinese Nutrition Society, the intake of other kinds was insufficient.At first trimester,second trimester and third trimester, energy intake was 2 086.70kcal, 3 200.40kcal and 3 650.70kcal, respectively, accounting for 90.70%,128.00% and 130.40% of RNI, respectively.The protein intake of them was 61.60kcal, 71.70kcal and 71.30kcal, respectively,accounting for 82.10%, 89.60%and 83.90%of RNI.Vegetable protein intake was too much, but animal protein intake was below the national average of 30%.Most of calcium and iron in dietary were from vegetable foods, accounting for 65% and 90%, respectively, and the uptake rate of them was low.The intake of Vitamin C, Vitamin B6 and folic acid was insufficient, and the lack of folic acid was severe.The intake of folic acid was 68.50μg, 84.90μg and 93.20μg at three trimesters respectively, accounting for 11.40%, 14.20% and 15.50% of RNI, respectively.Conclusion The dietary structure of pregnant women at different periods is not reasonable,and heat energy and nutrients can ’ t meet the needs of their body.At second and third trimester, the dietary is rather reasonable, but intakes of Vitamin B6, Vitamin C and folic acid are insufficient.Animal protein, calcium and iron are not taken sufficiently.%目的:了解乌鲁木齐市汉族孕妇膳食营养摄入及各种营养素达标情况,以便改善和提高孕妇的营养状况。方法随机选择

  6. Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients

    Energy Technology Data Exchange (ETDEWEB)

    Hitomi, Toshiaki [Department of Health and Environmental Sciences, Kyoto University, Kyoto (Japan); Habu, Toshiyuki [Radiation Biology Center, Kyoto University, Kyoto (Japan); Kobayashi, Hatasu; Okuda, Hiroko; Harada, Kouji H. [Department of Health and Environmental Sciences, Kyoto University, Kyoto (Japan); Osafune, Kenji [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Taura, Daisuke; Sone, Masakatsu [Department of Medicine and Clinical Science, Kyoto University, Kyoto (Japan); Asaka, Isao; Ameku, Tomonaga; Watanabe, Akira; Kasahara, Tomoko; Sudo, Tomomi; Shiota, Fumihiko [Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Hashikata, Hirokuni; Takagi, Yasushi [Department of Neurosurgery, Kyoto University,Kyoto (Japan); Morito, Daisuke [Faculty of Life Sciences, Kyoto Sangyo University, Kyoto (Japan); Miyamoto, Susumu [Department of Neurosurgery, Kyoto University,Kyoto (Japan); Nakao, Kazuwa [Department of Medicine and Clinical Science, Kyoto University, Kyoto (Japan); Koizumi, Akio, E-mail: koizumi.akio.5v@kyoto-u.ac.jp [Department of Health and Environmental Sciences, Kyoto University, Kyoto (Japan)

    2013-08-16

    Highlights: •Angiogenic activities were reduced in iPSECs from MMD patients. •Many mitosis-regulated genes were downregulated in iPSECs from MMD patients. •RNF213 R4810K downregulated Securin and inhibited angiogenic activity. •Securin suppression by siRNA reduced angiogenic activities of iPSECs and HUVECs. -- Abstract: Moyamoya disease (MMD) is a cerebrovascular disease characterized by occlusive lesions in the circle of Willis. The RNF213 R4810K polymorphism increases susceptibility to MMD. Induced pluripotent stem cells (iPSCs) were established from unaffected fibroblast donors with wild-type RNF213 alleles, and from carriers/patients with one or two RNF213 R4810K alleles. Angiogenic activities of iPSC-derived vascular endothelial cells (iPSECs) from patients and carriers were lower (49.0 ± 19.4%) than from wild-type subjects (p < 0.01). Gene expression profiles in iPSECs showed that Securin was down-regulated (p < 0.01) in carriers and patients. Overexpression of RNF213 R4810K downregulated Securin, inhibited angiogenic activity (36.0 ± 16.9%) and proliferation of humanumbilical vein endothelial cells (HUVECs) while overexpression of RNF213 wild type did not. Securin expression was downregulated using RNA interference techniques, which reduced the level of tube formation in iPSECs and HUVECs without inhibition of proliferation. RNF213 R4810K reduced angiogenic activities of iPSECs from patients with MMD, suggesting that it is a promising in vitro model for MMD.

  7. PSL(2,13)的最小级连通3度弧传递陪集图表示%The graphical representations of connected cubic arc-transitive coset graphs of minimum degree on PSL(2,13

    Institute of Scientific and Technical Information of China (English)

    汤利荣

    2011-01-01

    通过寻找给定群G的图表示,对PSL(2,13)的连通3度弧传递陪集图表示进行研究,得到了如下结果:PSL(2,13)的最小级连通3度弧传递陪集图表示的级是182.并且给出了该陪集图表示的例子.%This paper studies the graphical representations of connected cubic arc-transitive coset graphs onPSL(2, 13) based on the graphical representations of given group G. The following result is proved. PSL(2, 13)has the minimum degree 182 of connected cubic arc-transitive coset graphical representations. The example ofthe coset graphical representations is given.

  8. Carbon, Nitrogen, and Chalcogen Substitution Effects on 2,1,3-Benzothiadiazole Derivative: Theoretical Investigations of Electronic,Optical, and Charge Transport Properties

    Institute of Scientific and Technical Information of China (English)

    Bo Hu; Chan Yao; Qing-wei Wang; Hao Zhang; Jian-kang Yu

    2012-01-01

    A series of CH2,NH,O,and Se substituted 2,1,3-benzothiadiazole derivatives have been designed and investigated computationally to elucidate their potential as organic light-emitting materials for organic light-emitting diodes.Both ab initio Hartree-Fock and hybrid density functional methods are used.It is found that adjusting the central aromatic ring by replacing S by CH2,NH,O,and Se makes it possible to fine-tune the electronic,optical,and charge transport properties of the pristine molecule.

  9. Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

    OpenAIRE

    Tomizawa, Yoshio; Sekido, Yoshitaka; Kondo, Masashi; Gao, Boning; Yokota, Jun; Roche, Joëlle; Drabkin, Harry; Lerman, Michael I; Gazdar, Adi F.; Minna, John D.

    2001-01-01

    Semaphorins SEMA3B and its homologue SEMA3F are 3p21.3 candidate tumor suppressor genes (TSGs), the expression of which is frequently lost in lung cancers. To test the TSG candidacy of SEMA3B and SEMA3F, we transfected them into lung cancer NCI-H1299 cells, which do not express either gene. Colony formation of H1299 cells was reduced 90% after transfection with wild-type SEMA3B compared with the control vector. By contrast, only 30–40% reduction in colony formation was seen after the transfec...

  10. Diazidobis[4,4,5,5-tetramethyl-2-(1,3-thiazol-2-yl-2-imidazoline-1-oxyl-3-oxide-κ2O,N]manganese(II

    Directory of Open Access Journals (Sweden)

    Kai Jiang

    2009-02-01

    Full Text Available In the crystal structure of the title compound, [Mn(N32(C10H14N3O2S2], the Mn(II atom exhibits a roughly octahedral coordination geometry. The Mn(II atom lies on an inversion centre, thus the asymmetric unit comprises one half-molecule. The metal center is six-coordinated by two azide anions and by two chelating 4,4,5,5-tetramethyl-2-(1,3-thiazol-2-yl-2-imidazoline-1-oxyl-3-oxide nitronyl nitroxide radical ligands, leading to two six-membered chelate rings.

  11. Welding procedure of SA213-T91 and 12CrlMoV dissimilar steel tubes with minor diameter and thin-wall%SA213-T91与12Cr1MoV异种钢薄壁小径管的焊接工艺

    Institute of Scientific and Technical Information of China (English)

    许春义

    2001-01-01

    @@ 容量为300 MW的湛江发电厂一号机组,1996年11月高温再热器发生爆管,在更换吹损减薄管子的过程中出现了SA213-T91(φ60 mm×4mm)与12CrlMoV(φ60mm×4 mm)异种钢对接的焊接接头.

  12. Identifikasi Secara Serologi Galur Virus Flu Burung Subtipe H5N1 Clade 2.1.3 dan Clade 2.3.2 pada Ayam Petelur (SEROLOGICAL IDENTIFICATION OF AVIAN INFLUENZA STRAIN VIRUS SUBTYPE H5N1 CLADE 2.1.3 AND CLADE 2.3.2 FROM LAYER

    Directory of Open Access Journals (Sweden)

    Aprilia Kusumastuti

    2015-10-01

    Full Text Available The aim of the study was to know avian influenza (AI infection in field by using serology test in threemarketing area of AI vaccines. Haemagglutination inhibition methode was used in this test. There werefour antigen strains of AI subtype H5N1 clade 2.1.3 (AIstrainA/Chicken/West Java/PWT-WIJ/2006, AIstrain A/Chicken/Garut/BBVW-223/2007, AI strain A/Chicken/West Java-Nagrak/30/2007, and AI strainA/Chicken/Pekalongan/BBVW-208/2007 and 2 antigen strains of AI subtype H5N1 clade 2.3.2 (AI strainA/duck/Sukoharjo/BBVW-1428-9/2012 and AI strain A/duck/Sleman/BBVW-1463-10/2012 was used inthis study for HI test. The result presents that 93,33% chicken farms in three marketing area of PT. SanbioLaboratories have positive antibody titre to AI subtype H5N1 clade 2.1.3. This titre may be obtained fromAI clade 2.1.3 vaccination. From 15 samples, 92,86% are positive to AI subtype H5N1 clade 2.3.2A/duck/Sukoharjo/BBVW-1428-9/2012 and 92,31% are positive to A/duck/Sleman/BBVW-1463-10/2012 evenwithout AI clade 2.3.2 vaccination. This antibody titre may be obtained from AI clade 2.1.3 vaccine crossprotection or field infection.

  13. Pitting Behavior of HP2-13Cr in Simulated High Pressure and High Temperature Gas Well Environment%模拟高温高压气井环境中HP2-13Cr的点蚀行为研究

    Institute of Scientific and Technical Information of China (English)

    雷冰; 马元泰; 李瑛; 王福会; 常泽亮; 谢俊峰; 宋文文; 周理志

    2013-01-01

    The pitting behavior of HP2-13Cr in a simulated high pressure and high temperature gas well environment (including three periods: acidizing?returned residual acid? produced water) was investigated by OM/SEM observation. The results showed that the pitting was mainly occurred in the returned residual acid; the statistical analysis of the depth distribution of pits showed that the pitting rate in the period of returned residual acid was 7.56 mm/a, while 0.47 mm/a in the produced water. The depth distribution of pits followed Gumbel model and the shape of pits was shallow.%采用光学显微镜、扫描电子显微镜研究了HP2-13Cr油管钢在模拟高温高压气井环境中(酸化→返排残酸→采出水)点蚀行为的发展变化.结果表明:HP2-13Cr在服役过程中的点蚀主要在返排残酸阶段产生,残酸是引起HP2-13Cr点蚀的主要原因;统计了不同阶段点蚀坑深度的发展,得到返排残酸期间点蚀速率为7.56 mm/a,采出水期间点蚀发展速率为0.47 mm/a.点蚀坑深度的统计规律符合Gumbel分布,点蚀坑呈浅碟型.

  14. X-linked mental retardation, short stature, microcephaly and hypogonadism maps to Xp22.1-p21.3 in a Belgian family.

    Science.gov (United States)

    Van Esch, Hilde; Zanni, Ginevra; Holvoet, Maureen; Borghgraef, Martine; Chelly, Jamel; Fryns, Jean-Pierre; Devriendt, Koenraad

    2005-01-01

    X-linked mental retardation (XLMR) is a heterogeneous disorder that can be classified as either non-specific (MRX), when mental retardation is the only feature, or as syndromic mental retardation (MRXS). Genetic defects underlying XLMR are being identified at a rapid pace, often starting from X-chromosomal aberrations and XLMR families with a well-defined linkage interval. Here, we present a new family with a syndromic form of XLMR, including mild mental retardation, short stature, microcephaly and hypogonadism. Two-point linkage analysis with 24 polymorphic markers spanning the entire X chromosome was carried out. We could assign the causative gene to a 6 cM interval in Xp22.1-p21.3, with a maximum LOD score of 2.61 for markers DXS989 and DXS1061 at theta = 0.00. No mutations were found in the presented family for two known MRX genes mapping to this interval, ARX and IL1RAPL-1. These data indicate that the interval Xp22.1-p21.3 contains at least one additional MRXS gene.

  15. A First Comparison of the responses of a He4-based fast-neutron detector and a NE-213 liquid-scintillator reference detector

    CERN Document Server

    Jebali, R; Annand, J R M; Chandra, R; Davatz, G; Fissum, K G; Friederich, H; Gendotti, U; Hall-Wilton, R; Håkansson, E; Kanaki, K; Lundin, M; Murer, D; Nilsson, B; Rosborg, A; Svensson, H

    2015-01-01

    A first comparison has been made between the pulse-shape discrimination characteristics of a novel He4-based pressurized scintillation detector and a NE-213 liquid-scintillator reference detector using an Am/Be mixed-field neutron and gamma-ray source and a high-resolution scintillation-pulse digitizer. In particular, the capabilities of the two fast neutron detectors to discriminate between neutrons and gamma-rays were investigated. The NE-213 liquid-scintillator reference cell produced a wide range of scintillation-light yields in response to the gamma-ray field of the source. In stark contrast, the He4-based detector registered a maximum scintillation-light yield of 750 keVee to the same gamma-ray field. Pulse-shape discrimination for particles with scintillation-light yields of more than 750 keVee was excellent in the case of the He4-based detector, and above 750 keVee its signal was unambiguously neutron.

  16. Crystallization and initial crystallographic analysis of the Streptococcus parasanguinis FW213 Fap1-NRα adhesive domain at pH 5.0

    International Nuclear Information System (INIS)

    The adhesin fimbriae-associated protein 1 (Fap1) is a surface protein of Streptococcus parasanguinis FW213 and plays a major role in the formation of dental plaque in humans. Here, the adhesive domain Fap1-NRα, which is activated by acidic pH, has been crystallized at pH 5.0 and diffraction data have been collected to 3.0 Å resolution. The adhesin fimbriae-associated protein 1 (Fap1) is a surface protein of Streptococcus parasanguinis FW213 and plays a major role in the formation of dental plaque in humans. Increased adherence is highly correlated to a reduction in pH and acid activation has been mapped to a subdomain: Fap1-NRα. Here, Fap1-NRα has been crystallized at pH 5.0 and diffraction data have been collected to 3.0 Å resolution. The crystals belonged to space group P41212 or P43212, with unit-cell parameters a = b = 122.0, c = 117.8 Å. It was not possible to conclusively determine the number of molecules in the asymmetric unit and heavy-atom derivatives are now being prepared

  17. Targeted alpha-radionuclide therapy of functionally critically located gliomas with {sup 213}Bi-DOTA-[Thi{sup 8},Met(O{sub 2}){sup 11}]-substance P: a pilot trial

    Energy Technology Data Exchange (ETDEWEB)

    Cordier, D.; Merlo, A. [University Hospitals, Division of Neurosurgery, Basel (Switzerland); Forrer, F.; Good, S.; Mueller-Brand, J. [University Hospitals, Institute of Nuclear Medicine, Basel (Switzerland); Bruchertseifer, F.; Morgenstern, A.; Apostolidis, C. [Institute for Transuranium Elements, European Commission, Joint Research Centre, Karlsruhe (Germany); Maecke, H. [University Hospitals, Institute of Nuclear Medicine, Basel (Switzerland); University Hospital Basel, Nuclear Medicine and Radiological Chemistry, Basel (Switzerland); Reubi, J.C. [University of Berne, Institute of Pathology, Berne (Switzerland)

    2010-07-15

    Functionally critically located gliomas represent a challenging subgroup of intrinsic brain neoplasms. Standard therapeutic recommendations often cannot be applied, because radical treatment and preservation of neurological function are contrary goals. The successful targeting of gliomas with locally injected beta radiation-emitting {sup 90}Y-DOTAGA-substance P has been shown previously. However, in critically located tumours, the mean tissue range of 5 mm of {sup 90}Y may seriously damage adjacent brain areas. In contrast, the alpha radiation-emitting radionuclide {sup 213}Bi with a mean tissue range of 81 {mu}m may have a more favourable toxicity profile. Therefore, we evaluated locally injected {sup 213}Bi-DOTA-substance P in patients with critically located gliomas as the primary therapeutic modality. In a pilot study, we included five patients with critically located gliomas (WHO grades II-IV). After diagnosis by biopsy, {sup 213}Bi-DOTA-substance P was locally injected, followed by serial SPECT/CT and MR imaging and blood sampling. Besides feasibility and toxicity, the functional outcome was evaluated. Targeted radiopeptide therapy using {sup 213}Bi-DOTA-substance P was feasible and tolerated without additional neurological deficit. No local or systemic toxicity was observed. {sup 213}Bi-DOTA-substance P showed high retention at the target site. MR imaging was suggestive of radiation-induced necrosis and demarcation of the tumours, which was validated by subsequent resection. This study provides proof of concept that targeted local radiotherapy using {sup 213}Bi-DOTA-substance P is feasible and may represent an innovative and effective treatment for critically located gliomas. Primarily non-operable gliomas may become resectable with this treatment, thereby possibly improving the prognosis. (orig.)

  18. Delineation of a de novo 7q21.3q31.1 Deletion by CGH-SNP Arrays in a Girl with Multiple Congenital Anomalies Including Severe Glaucoma

    OpenAIRE

    Martínez-Jacobo, L.; Córdova-Fletes, C.; Ortiz-López, R.; Rivas, F; Saucedo-Carrasco, C.; Rojas-Martínez, A.

    2013-01-01

    In this study, we present a female patient with a constitutional de novo deletion in 7q21.3q31.1 as determined by G-banding and CGH-SNP arrays. She exhibited, among other features, psychomotor retardation, congenital severe bilateral glaucoma, a cleft palate, and heart defect. Microarray assay disclosed a deleted 12.5-Mb region roughly 88 kb downstream the ectrodactyly critical region; thus, the patient's final karyotype was 46,XX.arr 7q21.3q31.1(96,742,140-109,246,085)×1 dn. This girl repres...

  19. Single-dose anti-CD138 radioimmunotherapy: bismuth-213 is more efficient than lutetium-177 for treatment of multiple myeloma in a preclinical model

    Directory of Open Access Journals (Sweden)

    Nolwenn eFichou

    2015-11-01

    Full Text Available Objectives: Radioimmunotherapy (RIT has emerged as a potential treatment option for multiple myeloma (MM. In humans, a dosimetry study recently showed the relevance of RIT using an antibody targeting the CD138 antigen. The therapeutic efficacy of RIT using an anti-CD138 antibody coupled to 213Bi, an α-emitter, was also demonstrated in a preclinical MM model. Since then, RIT with β-emitters has shown efficacy in treating hematologic cancer. In this paper, we investigate the therapeutic efficacy of RIT in the 5T33 murine MM model using a new anti-CD138 monoclonal antibody labeled either with 213Bi for α-RIT or 177Lu for β-RIT.Methods: A new monoclonal anti-CD138 antibody, 9E7.4, was generated by immunizing a rat with a murine CD138-derived peptide. Antibody specificity was validated by flow cytometry, biodistribution and α-RIT studies. Then, a β-RIT dose-escalation assay with the 177Lu-radiolabeled 9E7.4 mAb was performed in KalwRij C57/BL6 mice 10 days after i.v. engraftment with 5T33 MM cells. Animal survival and toxicological parameters were assessed to define the optimal activity.Results: α-RIT performed with 3.7 MBq of 213Bi-labeled 9E7.4 anti-CD138 mAb increased median survival to 80 days compared to 37 days for the untreated control and effected cure in 45% of animals. β-RIT performed with 18.5 MBq of 177Lu-labeled 9E7.4 mAb was well tolerated and significantly increased mouse survival (54 versus 37 days in the control group; however, no mice were cured with this treatment.Conclusion: This study revealed the advantages of α-RIT in the treatment of MM in a preclinical model where β-RIT shows almost no efficacy.

  20. Polymorphism on chromosome 9p21.3 contributes to early-onset and severity of coronary artery disease in non-diabetic and type 2 diabetic patients

    Institute of Scientific and Technical Information of China (English)

    WANG Wei; PENG Wen-hui; LU Lin; ZHANG Rui-yan; ZHANG Qi; WANG Ling-jie; CHEN Qiu-jing; SHEN Wei-feng

    2011-01-01

    Background Susceptibility to coronary artery disease (CAD) and diabetes is encoded by distinct, tightly-linked single nucleotide polymorphisms on chromosome 9p21. This study aimed to examine the association of variant rs1333049 on chromosome 9p21.3 with early-onset and severity of CAD in Chinese patients with and without type 2 diabetes, and to determine the possible impact of rs1333049 on glucose metabolism and inflammation pathways.Methods Genotyping of variant rs1333049 on chromosome 9p21.3 was performed in 2387 patients with and without diabetes who were undergoing coronary angiography to evaluate suspected or established CAD. Serum levels of glucose, glycosylated hemoglobin A1c (HbA1c), insulin, high-sensitivity C-reactive protein, tumor necrosis factor-α, and interleukin-6 were also measured, and compared with each patient's genotype.Results The homozygous CC genotype of rs1333049 was significantly associated with CAD in diabetic (OR:1.270,P=0.044) and non-diabetic (OR: 1.369, P=0.011) patients after adjusting for traditional risk factors. There was an association between CC genotype and number of diseased vessels in diabetics (P=0.019), but not in non-diabetics (P=0.126). Among diabetic patients, CC genotype carriers had an increased risk of early-onset CAD (OR:. 2.367, P=0.008)and greater cumulative atherosclerotic burden compared with non-CC genotype carriers (Gensini score: 31.80±17.20 vs.23.09±21.63, P=0.039). No significant differences were observed between genotypes of rs1333049 in serum levels of glucose, insulin, HbA1c, or inflammatory cytokines for diabetic or non-diabetic patients with CAD.Conclusions This study demonstrated a significant association of rs1333049 polymorphism on chromosome 9p21.3 with CAD in Chinese diabetic and non-diabetic patients. The homozygous CC genotype of rs1333049 confers a magnified risk of early-onset and more severe CAD in diabetic patients through a novel biological pathway unrelated to glucose metabolism or

  1. The light-yield response of a NE-213 liquid-scintillator detector measured using 2 -- 6 MeV tagged neutrons

    CERN Document Server

    Scherzinger, J; Annand, J R M; Fissum, K G; Hall-Wilton, R; Kanaki, K; Lundin, M; Nilsson, B; Perrey, H; Rosborg, A; Svensson, H

    2016-01-01

    The response of a NE-213 liquid-scintillator detector has been measured using tagged neutrons from 2--6 MeV originating from an Am/Be neutron source. The neutron energies were determined using the time-of-flight technique. Pulse-shape discrimination was employed to discern between gamma-rays and neutrons. The behavior of both the fast (35 ns) and the combined fast and slow (475 ns) components of the neutron scintillation-light pulses were studied. Three different prescriptions were used to relate the neutron maximum energy-transfer edges to the corresponding recoil-proton scintillation-light yields, and the results were compared to simulations. Parametrizations which predict the fast or total light yield of the scintillation pulses were also tested. Our results agree with both existing data and existing parametrizations. We observe a clear sensitivity to the portion and length of the neutron scintillation-light pulse considered.

  2. A disseminated alveolar rhabdomyosarcoma in a 9-year-old boy disclosed by chromosomal translocation (2;13) (q35;q14)

    Science.gov (United States)

    Brichard, B; Ninane, J; Gosseye, S; Verellen-Dumoulin, C; Vermylen, C; Rodhain, J; Cornu, G

    1991-01-01

    A 9-year-old boy presented with a small subcutaneous tumor of the trunk and diffuse bone marrow involvement. The first histological diagnosis given was undifferentiated malignancy possibly of neural crest origin and chemotherapy was started immediately using vincristine, cyclophosphamide, cisplatin, and teniposide (OPEC). Complete response was achieved after four courses of chemotherapy. Histological slides were then reviewed and the final diagnosis of alveolar rhabdomyosarcoma (RMS) was retained. Moreover, chromosome analysis of malignant cells in the bone marrow revealed a translocation involving chromosomes 2 and 13:t(2;13) (q35;q14). This specific karyotype finding has been recently reported in a few cases and could be specific for alveolar RMS. The patient had a relapse 7 months after diagnosis and died 4 months later. PMID:1742179

  3. A Political Decision Disguised as Legal Argument? Opinion 2/13 and European Union Accession to the European Convention on Human Rights

    DEFF Research Database (Denmark)

    Butler, Graham

    2015-01-01

    of Copenhagen, Denmark. In this interview, carried out in June 2015 for the Utrecht Journal of International and European Law, David Thór Björgvinsson outlined his views to Graham Butler on Opinion 2/13 from the Court of Justice of the European Union on the Union’s accession to the European Convention on Human...... Rights, the workings of the European Court of Human Rights, and what the future may have in store for this Court.......David Thór Björgvinsson was a judge of the European Court of Human Rights between 2004 and 2013. During this period, he was involved in many important judgments, including Scoppola v Italy (No. 3), Eweida and others v United Kingdom, and Al-Jedda v the United Kingdom, amongst others, and went...

  4. Chloridobis[2-(1,3-thiazol-4-yl-κN-1H-benzimidazole-κN3]cobalt(II chloride dihydrate

    Directory of Open Access Journals (Sweden)

    Zhan-Wang Shi

    2012-08-01

    Full Text Available In the title compound, [CoCl(C10H7N3S2]Cl·2H2O, the CoII atom is five-coordinated by four N atoms from two chelating 2-(1,3-thiazol-4-yl-1H-benzimidazole ligands and one Cl atom in a distorted trigonal–bipyramidal geometry. In the crystal, N—H...O and O—H...Cl hydrogen bonds and π–π interactions between the thiazole, imidazole and benzene rings [centroid-to-centroid distances 3.546 (2, 3.683 (2 and 3.714 (2 Å] link the complex cations, chloride anions and uncoordinating water molecules into a three-dimensional network.

  5. Preparation of 2'-13C-L-Histidine Starting from 13C-Thiocyanate: Synthetic Access to Any Site-Directed Stable Isotope Enriched L-Histidine

    Directory of Open Access Journals (Sweden)

    Sarra Talab

    2014-01-01

    Full Text Available 1-Benzyl-2-(methylthio-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin. Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethyl-imidazolium chloride. This compound is converted under mild O’Donnell conditions into the corresponding L-histidine derivative. After deprotection L-histidine is obtained in good yield and 99% enantiomeric excess. 2'-13C-L-Histidine has been obtained via this new scheme with high (99% 13C incorporation starting with commercially available 13C- thiocyanate. This synthetic scheme allows access to any isotopomer of L-histidine and many other biologically important imidazole derivatives.

  6. SPECTROSCOPIC CONFIRMATION OF THREE z-DROPOUT GALAXIES AT z = 6.844-7.213: DEMOGRAPHICS OF Ly{alpha} EMISSION IN z {approx} 7 GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    Ono, Yoshiaki; Shimasaku, Kazuhiro; Nakajima, Kimihiko, E-mail: ono@astron.s.u-tokyo.ac.jp [Department of Astronomy, Graduate School of Science, University of Tokyo, Tokyo 113-0033 (Japan); Ouchi, Masami [Institute for Cosmic Ray Research, University of Tokyo, Kashiwa 277-8582 (Japan); Mobasher, Bahram; Nayyeri, Hooshang [Department of Physics and Astronomy, University of California, Riverside, CA 92521 (United States); Dickinson, Mark; Kartaltepe, Jeyhan S. [National Optical Astronomical Observatories, Tucson, AZ 85719 (United States); Penner, Kyle [Department of Astronomy, University of Arizona, Tucson, AZ 85721 (United States); Weiner, Benjamin J. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Stern, Daniel [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Kashikawa, Nobunari [Optical and Infrared Astronomy Division, National Astronomical Observatory of Japan, Tokyo 181-8588 (Japan); Spinrad, Hyron [Department of Astronomy, University of California, Berkeley, CA 94720 (United States)

    2012-01-10

    We present the results of our ultra-deep Keck/DEIMOS spectroscopy of z-dropout galaxies in the Subaru Deep Field and Great Observatories Origins Deep Survey's northern field. For 3 out of 11 objects, we detect an emission line at {approx}1 {mu}m with a signal-to-noise ratio of {approx}10. The lines show asymmetric profiles with high weighted skewness values, consistent with being Ly{alpha}, yielding redshifts of z = 7.213, 6.965, and 6.844. Specifically, we confirm the z = 7.213 object in two independent DEIMOS runs with different spectroscopic configurations. The z = 6.965 object is a known Ly{alpha} emitter, IOK-1, for which our improved spectrum at a higher resolution yields a robust skewness measurement. The three z-dropouts have Ly{alpha} fluxes of 3 Multiplication-Sign 10{sup -17} erg s{sup -1} cm{sup -2} and rest-frame equivalent widths EW{sup Ly{alpha}}{sub 0} = 33-43 A. Based on the largest spectroscopic sample of 43 z-dropouts, which is the combination of our and previous data, we find that the fraction of Ly{alpha}-emitting galaxies (EW{sup Ly{alpha}}{sub 0} > 25 A) is low at z {approx} 7; 17% {+-} 10% and 24% {+-} 12% for bright (M{sub UV} {approx_equal} -21) and faint (M{sub UV} {approx_equal} -19.5) galaxies, respectively. The fractions of Ly{alpha}-emitting galaxies drop from z {approx} 6 to 7 and the amplitude of the drop is larger for faint galaxies than for bright galaxies. These two pieces of evidence would indicate that the neutral hydrogen fraction of the intergalactic medium increases from z {approx} 6 to 7 and that the reionization proceeds from high- to low-density environments, as suggested by an inside-out reionization model.

  7. 4-(5-甲醛基-2-噻吩基)-7-(2-噻吩基)[2,1,3]苯并噻二唑的合成%Synthesis of 4-(5-formyl-2-thienyl)-7-(2-thienyl)[2,1,3] benzothiadiazole

    Institute of Scientific and Technical Information of China (English)

    李彦军; 陈功; 黄鹏程

    2007-01-01

    采用两种不同的途径合成了4-(5-甲醛基-2-噻吩基)-7-(2-噻吩基)[2,1,3]苯并噻二唑.研究结果表明,DMF/POCl3体系较n-BuLi/DMF体系产率更高.改变两种合成途径的反应条件,或用单醛化产物进一步醛化,均未发现二醛取代产物的生成.

  8. Conventional and Pretargeted Radioimmunotherapy Using Bismuth-213 to Target and Treat Non-Hodgkin Lymphomas Expressing CD20: A Preclinical Model toward Optimal Consolidation Therapy to Eradicate Minimal Residual Disease.

    Energy Technology Data Exchange (ETDEWEB)

    Park, Steven I.; Shenoi, Jaideep; Pagel, John M.; Hamlin, Donald K.; Wilbur, D. Scott; Orgun, Nural; Kenoyer, Aimee L.; Frayo, Shani; Axtman, Amanda; Back, Tom; Lin, Yukang; Fisher, Darrell R.; Gopal, Ajay K.; Green, Damian J.; Press, Oliver W.

    2010-11-18

    Radioimmunotherapy (RIT) with α-emitting radionuclides is an attractive approach for the treatment of minimal residual disease (MRD) because the short path lengths and high energies of α-particles produce optimal cytotoxicity at small target sites while minimizing damage to surrounding normal tissues. Pretargeted RIT (PRIT) using antibody-streptavidin (Ab-SA) constructs and radiolabeled biotin allows rapid, specific localization of radioactivity at tumor sites, making it an optimal method to target α-emitters with short half-lives, such as bismuth-213 (213Bi). Athymic mice bearing Ramos lymphoma xenografts received anti-CD20 1F5(scFv)4SA fusion protein (FP), followed by a dendrimeric clearing agent and [213Bi]DOTA-biotin. After 90 min, tumor uptake for 1F5(scFv)4SA was 16.5 ± 7.0 % injected dose per gram (ID/g) compared with 2.3 ± 0.9 % ID/g for the control FP. Mice treated with anti-CD20 PRIT and 600 µCi [213Bi]DOTA-biotin exhibited marked tumor growth delays compared to controls (mean tumor volume 0.01 ± 0.02 vs. 203.38 ± 83.03 mm3 after 19 days, respectively). The median survival for the 1F5(scFv)4SA group was 90 days compared to 23 days for the control FP (p<0.0001). Treatment was well tolerated, with no treatment-related mortalities. This study demonstrates the favorable biodistribution profile and excellent therapeutic efficacy attainable with 213Bi-labeled anti-CD20 PRIT.

  9. A Novel Cryptic Three-Way Translocation t(2;9;18)(p23.2;p21.3;q21.33) with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemia.

    Science.gov (United States)

    Othman, Moneeb A K; Rincic, Martina; Melo, Joana B; Carreira, Isabel M; Alhourani, Eyad; Hunstig, Friederike; Glaser, Anita; Liehr, Thomas

    2014-01-01

    Acute leukemia often presents with pure chromosomal resolution; thus, aberrations may not be detected by banding cytogenetics. Here, a case of 26-year-old male diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) and a normal karyotype after standard GTG-banding was studied retrospectively in detail by molecular cytogenetic and molecular approaches. Besides fluorescence in situ hybridization (FISH), multiplex ligation-dependent probe amplification (MLPA) and high resolution array-comparative genomic hybridization (aCGH) were applied. Thus, cryptic chromosomal aberrations not observed before were detected: three chromosomes were involved in a cytogenetically balanced occurring translocation t(2;9;18)(p23.2;p21.3;q21.33). Besides a translocation t(10;14)(q24;q11) was identified, an aberration known to be common in T-ALL. Due to the three-way translocation deletion of tumor suppressor genes CDKN2A/INK4A/p16, CDKN2B/INK4B/p15, and MTAP/ARF/p14 in 9p21.3 took place. Additionally RB1 in 13q14 was deleted. This patient, considered to have a normal karyotype after low resolution banding cytogenetics, was treated according to general protocol of anticancer therapy (ALL-BFM 95).

  10. A Novel Cryptic Three-Way Translocation t(2;9;18(p23.2;p21.3;q21.33 with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemia

    Directory of Open Access Journals (Sweden)

    Moneeb A. K. Othman

    2014-01-01

    Full Text Available Acute leukemia often presents with pure chromosomal resolution; thus, aberrations may not be detected by banding cytogenetics. Here, a case of 26-year-old male diagnosed with T-cell acute lymphoblastic leukemia (T-ALL and a normal karyotype after standard GTG-banding was studied retrospectively in detail by molecular cytogenetic and molecular approaches. Besides fluorescence in situ hybridization (FISH, multiplex ligation-dependent probe amplification (MLPA and high resolution array-comparative genomic hybridization (aCGH were applied. Thus, cryptic chromosomal aberrations not observed before were detected: three chromosomes were involved in a cytogenetically balanced occurring translocation t(2;9;18(p23.2;p21.3;q21.33. Besides a translocation t(10;14(q24;q11 was identified, an aberration known to be common in T-ALL. Due to the three-way translocation deletion of tumor suppressor genes CDKN2A/INK4A/p16, CDKN2B/INK4B/p15, and MTAP/ARF/p14 in 9p21.3 took place. Additionally RB1 in 13q14 was deleted. This patient, considered to have a normal karyotype after low resolution banding cytogenetics, was treated according to general protocol of anticancer therapy (ALL-BFM 95.

  11. MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth.

    Directory of Open Access Journals (Sweden)

    Ting-Fang Lo

    Full Text Available Methionine adenosyltransferase (MAT is the cellular enzyme that catalyzes the synthesis of S-adenosylmethionine (SAM, the principal biological methyl donor and a key regulator of hepatocyte proliferation, death and differentiation. Two genes, MAT1A and MAT2A, encode 2 distinct catalytic MAT isoforms. A third gene, MAT2B, encodes a MAT2A regulatory subunit. In hepatocellular carcinoma (HCC, MAT1A downregulation and MAT2A upregulation occur, known as the MAT1A:MAT2A switch. The switch is accompanied with an increasing expression of MAT2B, which results in decreased SAM levels and facilitates cancer cell growth. Berberine, an isoquinoline alkaloid isolated from many medicinal herbs such as Coptis chinensis, has a wide range of pharmacological effects including anti-cancer effects. Because drug-induced microRNAs have recently emerged as key regulators in guiding their pharmacological effects, we examined whether microRNA expression is differentially altered by berberine treatment in HCC. In this study, we used microRNA microarrays to find that the expression level of miR-21-3p (previously named miR-21* increased after berberine treatment in the HepG2 human hepatoma cell line. To predict the putative targets of miR-21-3p, we integrated the gene expression profiles of HepG2 cells after berberine treatment by comparing with a gene list generated from sequence-based microRNA target prediction software. We then confirmed these predictions through transfection of microRNA mimics and a 3' UTR reporter assay. Our findings provide the first evidence that miR-21-3p directly reduces the expression of MAT2A and MAT2B by targeting their 3' UTRs. In addition, an overexpression of miR-21-3p increased intracellular SAM contents, which have been proven to be a growth disadvantage for hepatoma cells. The overexpression of miR-21-3p suppresses growth and induces apoptosis in HepG2 cells. Overall, our results demonstrate that miR-21-3p functions as a tumor suppressor

  12. Screening of candidate tumor-suppressor genes in 3p21.3 and investigation of the methylation of gene promoters in oral squamous cell carcinoma.

    Science.gov (United States)

    Wang, Kai; Ling, Tianyou; Wu, Hanjiang; Zhang, Jie

    2013-03-01

    Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor. however, its pathological mechanisms have not yet been elucidated. In the present study, we screened for candidate tumor-suppressor genes (TSGs) related to OSCC among 10 candidate genes located in 3p21.3, a region abundant with TSGs based on previous studies, using semi-quantitative reverse transcription PCR (RT-PCR). Three genes, GNAT1, SEMA3B and AXUD1, with low or no expression in OSCC tissues and the cell line TCA8113 were selected, and the promoter methylation status was further analyzed by methylation-specific PCR (MS-PCR). Hypermethylation in the promoter regions of SEMA3B was found in OSCC tissues, and a significant difference in the frequency of methylation of SEMA3B was observed between OSCC and non-cancerous tissues. Furthermore, TCA8113 cells treated with 5-Aza-Cdc started to re-express SEMA3B at a concentration of 5 µM or higher. Our study confirmed that three candidate TSGs with low expression may be involved in OSCC and that hypermethylation in promoter regions may contribute to the low expression of SEMA3B. These findings offer novel insights for clarifying the molecular mechanisms of tumorigenesis of OSCC as well as for aiding in its clinical diagnosis and therapeutic strategy.

  13. Possible pressurized thermal shock events during large primary to secondary leakage. The Hungarian AGNES project and PRISE accident scenarios in VVER-440/V213 type reactor

    Energy Technology Data Exchange (ETDEWEB)

    Perneczky, L. [KFKI Atomic Energy Research Inst., Budabest (Hungary)

    1997-12-31

    Nuclear power plants of WWER-440/213-type have several special features. Consequently, the transient behaviour of such a reactor system should be different from the behaviour of the PWRs of western design. The opening of the steam generator (SG) collector cover, as a specific primary to secondary circuit leakage (PRISE) occurring in WWER-type reactors happened first time in Rovno NPP Unit I on January 22, 1982. Similar accident was studied in the framework of IAEA project RER/9/004 in 1987-88 using the RELAP4/mod6 code. The Hungarian AGNES (Advanced General and New Evaluation of Safety) project was performed in the period 1991-94 with the aim to reassess the safety of the Paks NPP using state-of-the-art techniques. The project comprised three type of analyses for the primary to secondary circuit leakages: Design Basis Accident (DBA) analyses, Pressurized Thermal Shock (PTS) study and deterministic analyses for Probabilistic Safety Analysis (PSA). Major part of the thermohydraulic analyses has been performed by the RELAP5/mod2.5/V251 code version with two input models. 32 refs.

  14. A quasar reddened by a sub-parsec sized, metal-rich and dusty cloud in a damped Lyman-alpha absorber at z=2.13

    CERN Document Server

    Krogager, J -K; Noterdaeme, P; Zafar, T; Møller, P; Ledoux, C; Krühler, T; Stockton, A

    2015-01-01

    We present a detailed analysis of a red quasar at z=2.32 with an intervening damped Lyman-alpha absorber (DLA) at z=2.13. Using high quality data from the X-shooter spectrograph at ESO Very Large Telescope we find that the absorber has a metallicity consistent with Solar. We observe strong C I and H$_2$ absorption indicating a cold, dense absorbing medium. Partial coverage effects are observed in the C I lines, from which we infer a covering fraction of $27 \\pm 6$ % and a physical diameter of the cloud of 0.1 pc. From the covering fraction and size, we estimate the size of the background quasar's broad line region. We search for emission from the DLA counterpart in optical and near-infrared imaging. No emission is observed in the optical data. However, we see tentative evidence for a counterpart in the H and K' band images. The DLA shows high depletion (as probed by [Fe/Zn]=-1.22) indicating that significant amounts of dust must be present in the DLA. By fitting the spectrum with various dust reddened quasar ...

  15. A search for pre-substellar cores and proto-brown dwarf candidates in Taurus: multiwavelength analysis in the B213-L1495 clouds

    CERN Document Server

    Palau, Aina; Morata, Ò; Stamatellos, D; Huélamo, N; Eiroa, C; Bayo, A; Morales-Calderón, M; Bouy, H; Ribas, Á; Asmus, D; Barrado, D

    2012-01-01

    In an attempt to study whether the formation of brown dwarfs (BDs) takes place as a scaled-down version of low-mass stars, we conducted IRAM30m/MAMBO-II observations at 1.2 mm in a sample of 12 proto-BD candidates selected from Spitzer/IRAC data in the B213-L1495 clouds in Taurus. Subsequent observations with the CSO at 350 micron, VLA at 3.6 and 6 cm, and IRAM30m/EMIR in the 12CO(1-0), 13CO(1-0), and N2H+(1-0) transitions were carried out toward the two most promising Spitzer/IRAC source(s), J042118 and J041757. J042118 is associated with a compact (<10 arcsec or <1400 AU) and faint source at 350 micron, while J041757 is associated with a partially resolved (~16 arcsec or ~2000 AU) and stronger source emitting at centimetre wavelengths with a flat spectral index. The corresponding masses of the dust condensations are ~1 and ~5 Mjup for J042118 and J041757, respectively. In addition, about 40 arcsec to the northeast of J041757 we detect a strong and extended submillimetre source, J041757-NE, which is no...

  16. Final Report for research grant entitled "Development of Reagents for Application of At-211 and Bi-213 to Targeted Radiotherapy of Cancer"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant was a one-year extension of another grant with the same title (DE-FG03-98ER62572). The objective of the studies was to continue in vivo evaluation of reagents to determine which changes in structure were most favorable for in vivo use. The focus of our studies was development and optimization of reagents for pretargeting alpha-emitting radionuclides At-211 or Bi-213 to cancer cells. Testing of the reagents was conducted in vitro and in animal model systems. During the funding period, all three specific aims set out in the proposed studies were worked on, and some additional studies directed at development of a method for direct labeling of proteins with At-211 were investigated. We evaluated reagents in two different approaches in 'two step' pretargeting protocols. These approaches are: (1) delivery of the radionuclide on recombinant streptavidin to bind with pretargeted biotinylated monoclonal antibody (mAb), and alternatively, (2) delivery of the radionuclide on a biotin derivative to bind with pretargeted antibody-streptavidin conjugates. The two approaches were investigated as it was unclear which will be superior for the short half-lived alpha-emitting radionuclides.

  17. Determination of medroxyprogesterone acetate in serum by HPLC with peroxyoxalate chemiluminescence detection using a fluorogenic reagent, 4-(N,N-dimethylaminosulphonyl)-7-hydrazino-2,1,3-benzoxadiazole.

    Science.gov (United States)

    Uzu, S; Imai, K; Nakashima, K; Akiyama, S

    1992-01-01

    The high-performance liquid chromatographic determination of medroxyprogesterone acetate (MPA) with peroxyoxalate chemiluminescence (PO-CL) detection is described. The spiked serum containing MPA was extracted on Bond-Elut C18 columns and derivatized with 4-(N,N-dimethylaminosulphonyl)-7-hydrazino-2,1,3-benzoxadiazole (DBD-H). The hydrazone of MPA with DBD-H was confirmed to be a mono-DBD-derivative. The reaction mixture was separated by direct injection onto a C18 analytical column, and quantified by PO-CL detection. The linear range of the standard curve, in serum, was 15.6-96.6 ng ml-1 with a detection limit of 9 ng ml-1 using only 100 microliters of serum, while the detection limit of standard MPA derivatized with DBD-H was 8.7 fmol per injection. The relative standard deviation of the method was 7.4% at 19.3 ng and 1.7% at 77.3 ng ml-1. PMID:1298405

  18. High-temperature oxidation studies of cold-sprayed Ni-20Cr and Ni-50Cr coatings on SAE 213-T22 boiler steel

    Science.gov (United States)

    Bala, Niraj; Singh, Harpreet; Prakash, Satya

    2009-05-01

    The high-temperature oxidation behavior of cold-sprayed Ni-20Cr and Ni-50Cr coatings on SAE 213-T22 boiler steel has been investigated at 900 °C in air under cyclic heating and cooling conditions for 50 cycles. The kinetics of oxidation of coated and bare boiler steel has been established with the help of weight change measurements. It was observed that all the coated and bare steels obeyed parabolic rate law of oxidation. X-ray diffraction, FE-SEM/EDAX and X-ray mapping techniques were used to analyse the oxidation products of the coated and uncoated boiler steel. The uncoated steel suffered corrosion in the form of intense spalling and peeling of its oxide scale, which was perhaps due to the formation of unprotective Fe 2O 3 oxide scale. Both the coatings showed better resistance to the air oxidation as compared to the uncoated steel. The Ni-50Cr coating was found to be more protective than the Ni-20Cr-coated steel. The formation of oxides and spinels of nickel and chromium may be contributing to the development of air oxidation resistance in the coatings.

  19. Corrosión por depósitos salinos de los aceros SA213-T22 y SA213-TP347H en presencia de una mezcla 80%V2O5-20%Na2SO4-20%Na2SO4

    Directory of Open Access Journals (Sweden)

    Romero, M. A.

    1998-02-01

    Full Text Available Many hot corrosion problems in industrial and utility boilers are caused by molten salts. The corrosion processes which occur in salts are of an electrochemical nature, and so they can be studied using electrochemical test methods. In this research, electrochemical techniques in molten salt systems have been used for the measurements of molten corrosion processes. Electrochemical test methods are described here for a salt mixture of 80%V2O5-20%Na2SO4 at 540-680°C. To establish better the electrochemical corrosion rate mearurements for molten salt systems, information from electrochemical potentiodynamic polarization curves, such as polarization resistance and Tafel slopes were used in this study to generate corrosion rate data. The salt was contained in a quartz crucible inside a stainless steel retort. The atmosphere used was air. A thermocouple sheathed with quartz glass was introduced into the molten salt for temperature monitoring and control. Two materials were tested in the molten mixture: SA213-T22 and SA213-TP347H steels. The corrosion rates values obtained using electrochemical methods were around 0.58-7.14 mm/yr (22.9-281 mpy. The corrosion rate increase with time.Muchos problemas de corrosión por depósitos salinos en la industria eléctrica, especialmente en los generadores de vapor, se deben al ataque por sales fundidas. El proceso de corrosión en sales fundidas es de naturaleza electroquímica; así, puede estudiarse empleando técnicas electroquímicas. Este proceso de corrosión en un sistema de sales fundidas, mezcla de 80%V2O5 y 20%Na2SO4 a temperaturas comprendidas entre 540 y 680°C, se evaluó en esta investigación por medio de técnicas electroquímicas. Para medir la velocidad de corrosión por depósitos salinos se parte de curvas de polarización potenciodinámicas determinando la resistencia de polarización por extrapolación de las pendientes de Tafel. Las sales se fundieron en un crisol de cuarzo dentro de un

  20. Delineation of a de novo 7q21.3q31.1 Deletion by CGH-SNP Arrays in a Girl with Multiple Congenital Anomalies Including Severe Glaucoma.

    Science.gov (United States)

    Martínez-Jacobo, L; Córdova-Fletes, C; Ortiz-López, R; Rivas, F; Saucedo-Carrasco, C; Rojas-Martínez, A

    2013-09-01

    In this study, we present a female patient with a constitutional de novo deletion in 7q21.3q31.1 as determined by G-banding and CGH-SNP arrays. She exhibited, among other features, psychomotor retardation, congenital severe bilateral glaucoma, a cleft palate, and heart defect. Microarray assay disclosed a deleted 12.5-Mb region roughly 88 kb downstream the ectrodactyly critical region; thus, the patient's final karyotype was 46,XX.arr 7q21.3q31.1(96,742,140-109,246,085)×1 dn. This girl represents the fourth patient described so far with congenital glaucoma and a deletion encompassing or overlapping the 7q21.3q31.1 region, and confirms the presence of a locus or loci related to such a clinical feature. According to our results, the proneness to ocular defects secondary to 7q intermediate deletions could be caused by co-deletion of TAC1, HBP1, and a small cluster of cytochrome P450 genes (subfamily 3A). This conclusion is supported by their functional roles and expression locations as well as because TAC1 is related to the functional pathway of the MYOC gene whose mutations are linked to glaucoma. Moreover, given that this girl is clinically reminiscent of several phenotypes related to diverse deletions within 7q21q32, our results and observations offer a general overview of the gene content of deletions/phenotypes overlapping 7q21.3q31.1 and confirm that loci distal to DLX genes including the CUX1 gene and potential regulatory elements downstream from DLX5 are unrelated to ectrodactyly. PMID:24167464

  1. A straightforward method for stereospecific assignment of val and leu prochiral methyl groups by solid-state NMR: Scrambling in the [2-13C]Glucose labeling scheme

    Science.gov (United States)

    Lv, Guohua; Faßhuber, Hannes Klaus; Loquet, Antoine; Demers, Jean-Philippe; Vijayan, Vinesh; Giller, Karin; Becker, Stefan; Lange, Adam

    2013-03-01

    The unambiguous stereospecific assignment of the prochiral methyl groups in Val and Leu plays an important role in the structural investigation of proteins by NMR. Here, we present a straightforward method for their stereospecific solid-state NMR assignment based on [2-13C]Glucose ([2-13C]Glc) as the sole carbon source during protein expression. The approach is fundamentally based on the stereo-selective biosynthetic pathway of Val and Leu, and the co-presence of [2-13C]pyruvate produced mainly by glycolysis and [3-13C]/[1,3-13C]pyruvate most probably formed through scrambling in the pentose phosphate pathway. As a consequence, the isotope spin pairs 13Cβ-13Cγ2 and 13Cα-13Cγ1 in Val, and 13Cγ-13Cδ2 and 13Cβ-13Cδ1 in Leu are obtained. The approach is successfully demonstrated with the stereospecific assignment of the methyl groups of Val and Leu of type 3 secretion system PrgI needles and microcrystalline ubiquitin.

  2. In vitro evaluation of {sup 213}Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage

    Energy Technology Data Exchange (ETDEWEB)

    Vandenbulcke, Katia; Lahorte, Christophe; Slegers, Guido [Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000, Gent (Belgium); De Vos, Filip; Dierckx, Rudi A. [Division of Nuclear Medicine, Ghent University Hospital (Belgium); Offner, Fritz [Department of Hematology, Ghent University Hospital (Belgium); Philippe, Jan [Department of Clinical Chemistry, Ghent University Hospital (Belgium); Apostolidis, Christos; Molinet, Roger; Nikula, Tuomo K. [European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe (Germany); Bacher, Klaus; De Gelder, Virginie; Vral, Anne; Thierens, Hubert [Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University (Belgium)

    2003-10-01

    External source radiotherapy and beta radioimmunotherapy (RIT) are effective treatments for lymphoid malignancies. The development of RIT with alpha emitters is attractive because of the high linear energy transfer (LET) and short path length, allowing higher tumour cell kill and lower toxicity to healthy tissues. We assessed the relative biological efficacy (RBE) of alpha RIT (in vitro) compared to external gamma irradiation with respect to induction of apoptosis in B chronic lymphocytic leukaemia (B-CLL) and induction of chromosomal damage in healthy donor B and T lymphocytes. The latter was measured by a micronucleus assay. {sup 213}Bi was eluted from a {sup 225}Ac generator and conjugated to CD20 antibody (rituximab) with CHX-A''-DTPA as a chelator. B-CLL cells from five patients were cultured for 24 h in RPMI/10% FCS while exposed to {sup 213}Bi conjugated to CD20 antibody or after external {sup 60}Co gamma irradiation. Binding assays were performed in samples of all patients to calculate the total absorbed dose. Apoptosis was scored by flow cytometric analyses of the cells stained with annexin V-FITC and 7-AAD. Apoptosis was expressed as % excess over spontaneous apoptosis in control. Full dose range experiments demonstrated {sup 213}Bi-conjugated CD20 antibody to be more effective than equivalent doses of external gamma irradiation, but showed that similar plateau values were reached at 10 Gy. The RBE for induction of apoptosis in B-CLL was 2 between 1.5 and 7 Gy. The micronucleus yield in lymphocytes of healthy volunteers was measured to assess the late toxicity caused by induction of chromosomal instability. While gamma radiation induced a steady increase in micronucleus yields in B and T cells, the damage induced by {sup 213}Bi was more dramatic, with RBE ranging from 5 to 2 between 0.1 Gy and 2 Gy respectively. In contrast to gamma irradiation, {sup 213}Bi inhibited mitogen-stimulated mitosis almost completely at 2 Gy. In conclusion, high

  3. In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage

    International Nuclear Information System (INIS)

    External source radiotherapy and beta radioimmunotherapy (RIT) are effective treatments for lymphoid malignancies. The development of RIT with alpha emitters is attractive because of the high linear energy transfer (LET) and short path length, allowing higher tumour cell kill and lower toxicity to healthy tissues. We assessed the relative biological efficacy (RBE) of alpha RIT (in vitro) compared to external gamma irradiation with respect to induction of apoptosis in B chronic lymphocytic leukaemia (B-CLL) and induction of chromosomal damage in healthy donor B and T lymphocytes. The latter was measured by a micronucleus assay. 213Bi was eluted from a 225Ac generator and conjugated to CD20 antibody (rituximab) with CHX-A''-DTPA as a chelator. B-CLL cells from five patients were cultured for 24 h in RPMI/10% FCS while exposed to 213Bi conjugated to CD20 antibody or after external 60Co gamma irradiation. Binding assays were performed in samples of all patients to calculate the total absorbed dose. Apoptosis was scored by flow cytometric analyses of the cells stained with annexin V-FITC and 7-AAD. Apoptosis was expressed as % excess over spontaneous apoptosis in control. Full dose range experiments demonstrated 213Bi-conjugated CD20 antibody to be more effective than equivalent doses of external gamma irradiation, but showed that similar plateau values were reached at 10 Gy. The RBE for induction of apoptosis in B-CLL was 2 between 1.5 and 7 Gy. The micronucleus yield in lymphocytes of healthy volunteers was measured to assess the late toxicity caused by induction of chromosomal instability. While gamma radiation induced a steady increase in micronucleus yields in B and T cells, the damage induced by 213Bi was more dramatic, with RBE ranging from 5 to 2 between 0.1 Gy and 2 Gy respectively. In contrast to gamma irradiation, 213Bi inhibited mitogen-stimulated mitosis almost completely at 2 Gy. In conclusion, high-LET targeted alpha particle exposure killed B-CLL cells

  4. In-situ Trace Element and REE Analysis of Garnet Porphyroblast from the Murphy Belt Drill Core by 213 nm Laser Ablation High Resolution ICPMS

    Science.gov (United States)

    LaTour, T. E.; Ghazi, A. M.

    2001-12-01

    Laser ablation coupled with high resolution inductively coupled plasma mass spectrometry (LA-HR-ICPMS) is a powerful tool for in-situ trace element analysis of solid samples on the micron scale. Recent development of the 213 nm (quintupled) Nd-YAG laser has significantly improved upon the more widely used 266 nm laser. In this study we focus on analysis of zoned garnets from the Murphy Marble Belt with a Universal Platform (UP) Merchantek/New Wave 213 nm laser ablation system, coupled with a Finnigan MAT Element2 high resolution ICPMS which is equipped with the fast scanning power supply magnet. Laser ablation parameters included 60 um spots size, 100% energy level, repetition rate of 20Hz and scanning speed of 16-20 um/seconds. Garnets were analyzed for Mg, Rb, Sr, Y, Zr, Nb, Hf and REE and the data used here were obtained by using a line scan across the diameter of the garnet porphyroblasts. Aluminous schist from drill core from the Murphy Marble Belt of the Western Blue Ridge of Georgia contains two generations of garnet, gt I and gt II. Gt II occurs as stand-alone grains and as overgrowths on gt I. Gt I grew in conjunction with development of biotite (bi) schistosity. Gt-bi geothermometry yields 512-531oC for gt I, consistent upper greenschist metamorphism. Growth of gt I was followed by growth of gt II, kyanite (ky), and staurolite (st), in turn followed by growth of sillimanite (si), large muscovite (ms) porphyroclasts, (and gt II?), associated with a high-T mylonitic event in which plagioclase and aggregates of ky+st+bi were converted to porphyroclasts, lying in a medium grained si-ms-bi schistosity. This was followed by a retrograde mylonitic event which partially converted si, ky, st, and large ms to fine grained ms schistosity which is the dominant schistosity in the rocks. Gt II is distinctly higher in CaO and lower in MnO than gt I, suggesting that it grew under high pressure, perhaps resulting from overthrusting which formed the high-T mylonitic

  5. Identification of a microdeletion at 7q21.3 with fluorescence in situ hybridization in a patient with split hand/split foot (ectrodactyly)

    Energy Technology Data Exchange (ETDEWEB)

    Hudgins, L. [Children`s Hospital and Medical Center, Seattle, WA (United States); Massa, H.; Disteche, C. [Univ. of Washington, Seattle, WA (United States)] [and others

    1994-09-01

    Split hand/split foot (SHSF), often referred to as ectrodactyly or lobster claw deformity, is a human developmental disorder characterized by a deep median cleft of the hands and feet, missing digits, and fusion of remaining digits. This anomaly can be seen alone, frequently autosomal dominant, or in association with other abnormalities. One locus for this defect has been localized to chromosome 7q21.3-q22.1. We report a patient with SHSF plus mental retardation, short stature and dysmorphic features who was found to have a microdeletion at this locus detected only with the aid of fluorescence in situ hybridization (FISH). T.H. is a 7 y.o. male who was referred for evaluation of foot anomalies and mild mental retardation. History was remarkable for growth retardation of postnatal onset and hypotonia. Renal ultrasound and audiology evaluation were normal. Physical exam revealed dysplastic ears, micrognathia, long philtrum, high narrow palate, and malformations of the feet consistent with SHSF. Family history was negative for limb abnormalities and mental retardation. A number of patients with SHSF and other anomalies have been found to have deletions involving chromosome 7q21-q22; therefore, high resolution chromosome analysis was performed in T.H. but was inconclusive. Cosmids and yeast artificial chromosomes which we had previously mapped to the SHSF critical region were used as FISH probes and a microdeletion was detected. We were thus able to determine the etiology of this child`s abnormalities and provide accurate genetic counseling, which would not have been possible with standard cytogenetic techniques. This technique also allowed us to further refine the SHSF critical region. This case illustrates the utility of FISH for the rapid identification of suspect microdeletions in SHSF. This approach should also be useful as an expeditious way of defining the critical regions for the location of genes which give rise to other developmental malformations.

  6. Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13 chromosomal translocation in alveolar rhabdomyosarcoma.

    Directory of Open Access Journals (Sweden)

    Qiande Hu

    Full Text Available Alveolar rhabdomyosarcoma (ARMS is an aggressive pediatric cancer of skeletal muscle. More than 70% of ARMS tumors carry balanced t(2;13 chromosomal translocation that leads to the production of two novel fusion genes, PAX3-FKHR and FKHR-PAX3. While the PAX3-FKHR gene has been intensely studied, the reciprocal FKHR-PAX3 gene has rarely been described. We report here the cloning and functional characterization of the FKHR-PAX3 gene as the first step towards a better understanding of its potential impact on ARMS biology. From RH30 ARMS cells, we detected and isolated three versions of FKHR-PAX3 cDNAs whose C-terminal sequences corresponded to PAX3c, PAX3d, and PAX3e isoforms. Unlike the nuclear-specific localization of PAX3-FKHR, the reciprocal FKHR-PAX3 proteins stayed predominantly in the cytoplasm. FKHR-PAX3 potently inhibited myogenesis in both non-transformed myoblast cells and ARMS cells. We showed that FKHR-PAX3 was not a classic oncogene but could act as a facilitator in oncogenic pathways by stabilizing PAX3-FKHR expression, enhancing cell proliferation, clonogenicity, anchorage-independent growth, and matrix adhesion in vitro, and accelerating the onset of tumor formation in xenograft mouse model in vivo. In addition to these pro-oncogenic behaviors, FKHR-PAX3 also negatively affected cell migration and invasion in vitro and lung metastasis in vivo. Taken together, these functional characteristics suggested that FKHR-PAX3 might have a critical role in the early stage of ARMS development.

  7. System for recovery of daughter isotopes from a source material

    Science.gov (United States)

    Tranter, Troy J [Idaho Falls, ID; Todd, Terry A [Aberdeen, ID; Lewis, Leroy C [Idaho Falls, ID; Henscheid, Joseph P [Idaho Falls, ID

    2009-08-04

    A method of separating isotopes from a mixture containing at least two isotopes in a solution is disclosed. A first isotope is precipitated and is collected from the solution. A daughter isotope is generated and collected from the first isotope. The invention includes a method of producing an actinium-225/bismuth-213 product from a material containing thorium-229 and thorium-232. A solution is formed containing nitric acid and the material containing thorium-229 and thorium-232, and iodate is added to form a thorium iodate precipitate. A supernatant is separated from the thorium iodate precipitate and a second volume of nitric acid is added to the thorium iodate precipitate. The thorium iodate precipitate is stored and a decay product comprising actinium-225 and bismuth-213 is generated in the second volume of nitric acid, which is then separated from the thorium iodate precipitate, filtered, and treated using at least one chromatographic procedure. A system for producing an actinium-225/bismuth-213 product is also disclosed.

  8. 21.3.Other Psychosis

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930407 Lymphocyte β-adrenergic receptorfunction in depressed patients.FAN Xiaodong(笵肖冬),et al.Instit Ment Health,Beijing MedUniv,100083.Chin J Neurol & Psychiat 1992;25(6):322—324.Lymphocyte β-adrenergic receptor functionof 20 depressed patients and 18 healthy volun-teers were measured by using radio-ligandbinding technique.It was found that the affinityand sensitivity of this receptor were significantlyhigher in endogenous depressed patients thanthose in normal controls.After the electro-acupuncture-treatment (EAT),lymphocyte β—receptor function decreased in patients whoresponded well to EAT,but still did not reachnormal level.(Authors)

  9. 21.3.Other psychosis

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920199 Quantitative EEG analysis and itsvalue in differential diagnosis of depression:power spectrum and coherence analysis.LIUXiang (刘向),et al.Instit Merit Health,Beijing MedUniv,100083.Chin J Neurol & Psychiat 1991; 24(5): 275-277.Power spectrum and coherence analysis weretaken on 47 depressive patients and 43 normal

  10. IMPACT OF LOCUS 9P21.3 SINGLE NUCLEOTIDE POLYMORPHISMS ON CORONARY ATHEROSCLEROSIS SEVERITY AND LONG-TERM OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENT WITH MYOCARDIAL INFARCTION

    Directory of Open Access Journals (Sweden)

    P. A. Shesternya

    2015-09-01

    Full Text Available Aim. To investigate association between 9p21.3 locus single nucleotide polymorphisms (SNPs and coronary atherosclerosis severity and long-term outcomes after percutaneous coronary intervention (PCI in patients with myocardial infarction (MI.Material and methods. A total of 255 Caucasian patients (211 male, 44 female; aged up to 65 years, on the average 52.56±7.98 years with MI were recruited into the study from 01.01.2009 to 30.06.2010. All participants were included into the study after written informed consent. Genome DNA was extracted from leukocytes of venous blood by the phenol-chloroform extraction method. Two SNPs rs10757278 and rs1333049 (locus 9p21.3 were tested by real-time polymerase chain reaction (PCR according to protocol (probes TaqMan, Applied Biosystems, 7900HT. The coronary angiograms were reviewed by independent angiographers who were blinded to the results of the genotyp- ing (Philips Allura Xper FD10. The total number of lesions, Gensini score and SYNTAX score were derived. Follow-up lasted two years.Results. Locus 9р21.3 genotypes CC rs1333049 and GG rs10757278 demonstrated a direct strong association with severity of coronary atheromatous burden (left main coro- nary artery stenosis, total number of lesions, Gensini score. There are not influence of locus 9p21.3 on mortality, recurrent MI, hospitalization due to unstable angina, repeated PCI, stroke during follow-up period (6, 12, 24 months. Frequency of the genotype СС rs1333049 among patients with recurrent MI was 20% (without recurrent MI — 27.4%; р=0.54; with hospitalization due to unstable angina — 27.5% (without hospitalization — 26.4%; р=0.82; with repeated PCI — 24.0% (without repeated PCI — 27.2%; р=0.97; among died patients — 29.8% (among survived ones — 26.4%; р=0.76. Frequencies of the genotype GG rs10757278 were similar: recurrent MI (yes — 18.8%; no — 26.4%; р=0.49; hospitalization due to unstable angina (yes — 28%; no — 25

  11. IMPACT OF LOCUS 9P21.3 SINGLE NUCLEOTIDE POLYMORPHISMS ON CORONARY ATHEROSCLEROSIS SEVERITY AND LONG-TERM OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENT WITH MYOCARDIAL INFARCTION

    Directory of Open Access Journals (Sweden)

    P. A. Shesternya

    2013-01-01

    Full Text Available Aim. To investigate association between 9p21.3 locus single nucleotide polymorphisms (SNPs and coronary atherosclerosis severity and long-term outcomes after percutaneous coronary intervention (PCI in patients with myocardial infarction (MI.Material and methods. A total of 255 Caucasian patients (211 male, 44 female; aged up to 65 years, on the average 52.56±7.98 years with MI were recruited into the study from 01.01.2009 to 30.06.2010. All participants were included into the study after written informed consent. Genome DNA was extracted from leukocytes of venous blood by the phenol-chloroform extraction method. Two SNPs rs10757278 and rs1333049 (locus 9p21.3 were tested by real-time polymerase chain reaction (PCR according to protocol (probes TaqMan, Applied Biosystems, 7900HT. The coronary angiograms were reviewed by independent angiographers who were blinded to the results of the genotyp- ing (Philips Allura Xper FD10. The total number of lesions, Gensini score and SYNTAX score were derived. Follow-up lasted two years.Results. Locus 9р21.3 genotypes CC rs1333049 and GG rs10757278 demonstrated a direct strong association with severity of coronary atheromatous burden (left main coro- nary artery stenosis, total number of lesions, Gensini score. There are not influence of locus 9p21.3 on mortality, recurrent MI, hospitalization due to unstable angina, repeated PCI, stroke during follow-up period (6, 12, 24 months. Frequency of the genotype СС rs1333049 among patients with recurrent MI was 20% (without recurrent MI — 27.4%; р=0.54; with hospitalization due to unstable angina — 27.5% (without hospitalization — 26.4%; р=0.82; with repeated PCI — 24.0% (without repeated PCI — 27.2%; р=0.97; among died patients — 29.8% (among survived ones — 26.4%; р=0.76. Frequencies of the genotype GG rs10757278 were similar: recurrent MI (yes — 18.8%; no — 26.4%; р=0.49; hospitalization due to unstable angina (yes — 28%; no — 25

  12. Influence of physical properties and chemical composition of sample on formation of aerosol particles generated by nanosecond laser ablation at 213 nm

    Energy Technology Data Exchange (ETDEWEB)

    Hola, Marketa, E-mail: mhola@sci.muni.c [Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno (Czech Republic); Konecna, Veronika [Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno (Czech Republic); Mikuska, Pavel [Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic v.v.i., Veveri 97, 602 00 Brno (Czech Republic); Kaiser, Jozef [Institute of Physical Engineering, Faculty of Mechanical Engineering, Brno University of Technology, Technicka 2896/2, 616 69 Brno (Czech Republic); Kanicky, Viktor [Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno (Czech Republic)

    2010-01-15

    The influence of sample properties and composition on the size and concentration of aerosol particles generated by nanosecond Nd:YAG laser ablation at 213 nm was investigated for three sets of different materials, each containing five specimens with a similar matrix (Co-cemented carbides with a variable content of W and Co, steel samples with minor differences in elemental content and silica glasses with various colors). The concentration of ablated particles (particle number concentration, PNC) was measured in two size ranges (10-250 nm and 0.25-17 mum) using an optical aerosol spectrometer. The shapes and volumes of the ablation craters were obtained by Scanning Electron Microscopy (SEM) and by an optical profilometer, respectively. Additionally, the structure of the laser-generated particles was studied after their collection on a filter using SEM. The results of particle concentration measurements showed a significant dominance of particles smaller than 250 nm in comparison with larger particles, irrespective of the kind of material. Even if the number of particles larger than 0.25 mum is negligible (up to 0.1%), the volume of large particles that left the ablation cell can reach 50% of the whole particle volume depending on the material. Study of the ablation craters and the laser-generated particles showed a various number of particles produced by different ablation mechanisms (particle splashing or condensation), but the similar character of released particles for all materials was observed by SEM after particle collection on the membrane filter. The created aerosol always consisted of two main structures - spherical particles with diameters from tenths to units of micrometers originally ejected from the molten surface layer and mum-sized 'fibres' composed of primary agglomerates with diameters in the range between tens and hundreds of nanometers. The shape and structure of ablation craters were in good agreement with particle concentration

  13. Alteration of interaction between astrocytes and neurons in different stages of diabetes: a nuclear magnetic resonance study using [1-(13)C]glucose and [2-(13)C]acetate.

    Science.gov (United States)

    Wang, Na; Zhao, Liang-Cai; Zheng, Yong-Quan; Dong, Min-Jian; Su, Yongchao; Chen, Wei-Jian; Hu, Zi-Long; Yang, Yun-Jun; Gao, Hong-Chang

    2015-01-01

    Increasing evidence has shown that the brain is a site of diabetic end-organ damage. This study investigates cerebral metabolism and the interactions between astrocytes and neurons at different stages of diabetes to identify the potential pathogenesis of diabetic encephalopathy. [1-(13)C]glucose or [2-(13)C]acetate is infused into 1- and 15-week diabetic rats, the brain extracts of which are analyzed by using (1)H and (13)C magnetic resonance spectroscopy. The (13)C-labeling pattern and enrichment of cerebral metabolites are also investigated. The increased (13)C incorporation in the glutamine, glutamate, and γ-aminobutyric acid carbons from [2-(13)C]acetate suggests that the astrocytic mitochondrial metabolism is enhanced in 1-week diabetic rats. By contrast, the decreased labeling from [1-(13)C]glucose reflected that the neuronal mitochondrial metabolism is impaired. As diabetes developed to 15 weeks, glutamine and glutamate concentrations significantly decreased. The increased labeling of glutamine C4 but unchanged labeling of glutamate C4 from [2-(13)C]acetate suggests decreased astrocyte supply to the neurons. In addition, the enhanced pyruvate recycling pathway manifested by the increased lactate C2 enrichment in 1-week diabetic rats is weakened in 15-week diabetic rats. Our study demonstrates the overall metabolism disturbances, changes in specific metabolic pathways, and interaction between astrocytes and neurons during the onset and development of diabetes. These results contribute to the mechanistic understanding of diabetes pathogenesis and evolution. PMID:25048983

  14. 2,1,3-benzothiadiazole-5,6-dicarboxylic imide - A versatile building block for additive- and annealing-free processing of organic solar cells with effi ciencies exceeding 8%

    KAUST Repository

    Nielsen, Christian Bergenstof

    2014-12-15

    A new photoactive polymer comprising benzo[1,2-b:3,4-b′:5,6-d′]trithiophene and 2,1,3-benzothiadiazole-5,6-dicarboxylic imide is reported. The synthetic design allows for alkyl chains to be introduced on both electron-rich and electron-deficient components, which in turn allows for rapid optimization of the alkyl chain substitution pattern. Consequently, the optimized polymer shows a maximum efficiency of 8.3% in organic photovoltaic devices processed in commercially viable fashion without solvent additives, annealing, or device engineering.

  15. A novel description of a syndrome consisting of 7q21.3 deletion including DYNC1I1 with preserved DLX5/6 without ectrodactyly: a case report

    OpenAIRE

    Ramos-Zaldívar, Héctor M.; Martínez-Irías, Daniel G.; Espinoza-Moreno, Nelson A.; Napky-Rajo, José S.; Bueso-Aguilar, Tulio A.; Reyes-Perdomo, Karla G.; Montes-Gambarelli, Jimena A.; Euceda, Isis M.; Ponce-Barahona, Aldo F.; Gámez-Fernández, Carlos A.; Moncada-Arita, Wilberg A.; Palomo-Bermúdez, Victoria A.; Jiménez-Faraj, Julia E.; Hernández-Padilla, Amanda G.; Olivera, Denys A.

    2016-01-01

    Background Chromosomal region 7q21.3 comprises approximately 5.2 mega base pairs that include genes DLX5/6, SHFM1, and DYNC1I1 associated with split hand/split foot malformation 1. So far, there are reports of eight families with deletion of DYNC1I1 and preserved DLX5/6 associated with ectrodactyly. From these families, only three patients did not present ectrodactyly and, unlike our patient, no other cases have been described as having craniofacial dysmorphology, mitral valve prolapse, kypho...

  16. Report of a consultants' meeting on containment and confinement performance in NPPS with WWER 440/213 and 440/230 reactors

    International Nuclear Information System (INIS)

    The reactors WWER 440 model V-230 being operated in several countries of central and eastern Europe were designed in the 1960-ies assuming that the design basis accident can be limited to a break of a pipe of 100 mm diameter fitted with an orifice of 32 mm diameter. This assumption presently judged to be inadequate according to the international safety requirements, was used to determine the Emergency Core Cooling System. For this size of the break, the spray system of the reactor building was designed to prevent uncontrolled releases to the environment. For larger breaks, till full rupture of one of two pressurizer surge lines of 200 mm diameter each, large flaps were designed to open during the initial pressure peak after the accident and release to the environment large amounts of steam escaping from the broken reactor coolant system (RCS). In view of this initial release of radioactive medium and due to its other unsatisfactory features, the building surrounding the WWER 440/230 reactor is not called a containment, but is said to fulfill a confining function, in short it is termed a confinement. The shortcomings of the WWER 440/230 confinements have been long recognized and the newer model of WWER 440 units, called model V-213, has been provided with an improved building of higher leaktightness and higher strength, containing a complicated system of water trays and air traps designed to condense steam and remove a part of the air from the reactor compartments after large break loss of coolant accident (LB LOCA). For such case, the system provides fast pressure decrease in the containment to subatmospheric values and thus prevents any significant releases of radioactivity to the environment. As the main process is that of steam bubble condensation in water, the system is called bubbler condenser containment. The bubbler condenser containment was the answer to the problem of providing the old WWER 440 model 230 units with a reliable containment without excessive

  17. 住院糖尿病患者的老年综合征调查%Geriatric syndrome:a survey on 213 elderly inpatients with diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    王秋梅; 朱鸣雷; 曾平; 康琳; 葛楠; 曲璇; 刘晓红

    2015-01-01

    Objective To investigate the prevalence of geriatric syndrome in the hospitalized elderly with diabetes mellitus. Methods A total of 213 elderly patients at an age of over 65 years with type 2 diabetes mellitus admitted in our department from July 2012 to September 2014 were enrolled in this study. Each subject was assessed for cognitive impairment, mood, sleep problems, falls risk, urinary incontinence, nutrition risk, and impairment of activity of daily living within 48h after admission. Results The cohort was at an age of (74.7±6.6) years, with a duration of diabetes for (12.4±8.9) years (median 10 years), and with 3 to 27 types of comorbidities. They averagely had (3.3±1.7) geriatric syndrome. Sixty percent of them had polypharmacy, and 40%to 50% had impairment in activities of daily living. The prevalence of cognitive impairment, emotional disorder, chronic pain and high risk of falling was 39.0%, 29.0%, 31.9%and 43.0%, respectively. The incidence of falling risk was higher in the patients with longer disease course [54.8%(course>10 years) vs 37.9%(course≤10 years)]. When compared with the well-controlled diabetic patients (HbA1c ≤7.5%), the poor-controlled patients (HbA1c>7.5%) were found to have longer disease course [(17.7±10.5) vs (10.9±7.7) years], higher risk rate of falling (61.7% vs 38.5%), and higher incidences of sleep disorder (51.1% vs 34.9%), but lower incidence of cognitive impairment (27.6% vs 44.8%; all P<0.05). Conclusion The elderly with diabetes mellitus have high risks of cognitive impairment, emotional disorder, chronic pain and falling risks. We need to make comprehensive geriatric assessment and individualized intervention for them.%目的:探讨住院老年糖尿病患者的老年综合征罹患情况。方法对北京协和医院内科老年病房2012年7月至2014年9月收治的213例≥65岁老年糖尿病患者进行老年综合评估,评估患者的认知、情绪、睡眠障碍、跌倒、尿失禁、营养风险和

  18. Advance in Syntheses of 2,1,3 -Benzothiadiazole conjugated compounds%苯并噻二唑共轭有机分子合成研究进展

    Institute of Scientific and Technical Information of China (English)

    黄旦翔; 夏萌; 彭雄伟; 黎太浩; 程晓红

    2015-01-01

    2,1,3-苯并噻二唑(BTD)共轭有机分子具有优异的光电特性,广泛应用于有机发光二极管、太阳能电池、液晶、荧光探针、光电管等方面。综述了以金属催化的偶联反应为关键步骤的2,1,3-苯并噻二唑(BTD)共轭有机分子的合成方法,包括 Suzuki 偶联反应,Stille 偶合反应,Heck 偶联反应,Sonogashir 偶联反应,Nigishi 偶联反应,Ullmann 偶联反应等。%2,1,3 -Benzothiadiazole conjugated compounds are one of the most active research area in the optoelectronic materials due to their outstanding optical and electrical properties and have great potentials as organic light -emitting diodes,solar cells,liquid crystals,fluorescent sensors and photovoltaic cells ect. This review covers the various synthetic methods reported for 2,1,3 -Benzothiadiazole (BTD)conjugated compounds in recent years.Including Suzuki coupling reaction,Stille coupling reaction,Heck coupling reac-tion ,Sonogashira coupling reaction,Nigishi coupling reaction,Ullmann coupling reaction ect.

  19. A randomised double-blind clinical trial of two yellow fever vaccines prepared with substrains 17DD and 17D-213/77 in children nine-23 months old.

    Science.gov (United States)

    2015-09-01

    This randomised, double-blind, multicentre study with children nine-23 months old evaluated the immunogenicity of yellow fever (YF) vaccines prepared with substrains 17DD and 17D-213/77. YF antibodies were titered before and 30 or more days after vaccination. Seropositivity and seroconversion were analysed according to the maternal serological status and the collaborating centre. A total of 1,966 children were randomised in the municipalities of the states of Mato Grosso do Sul, Minas Gerais and São Paulo and blood samples were collected from 1,714 mothers. Seropositivity was observed in 78.6% of mothers and 8.9% of children before vaccination. After vaccination, seropositivity rates of 81.9% and 83.2%, seroconversion rates of 84.8% and 85.8% and rates of a four-fold increase over the pre-vaccination titre of 77.6% and 81.8% were observed in the 17D-213/77 and 17DD subgroups, respectively. There was no association with maternal immunity. Among children aged 12 months or older, the seroconversion rates of 69% were associated with concomitant vaccination against measles, mumps and rubella. The data were not conclusive regarding the interference of maternal immunity in the immune response to the YF vaccine, but they suggest interference from other vaccines. The failures in seroconversion after vaccination support the recommendation of a booster dose in children within 10 years of the first dose.

  20. A novel strategy to isolate cell-envelope mutants resistant to phage infection: bacteriophage mEp213 requires lipopolysaccharides in addition to FhuA to enter Escherichia coli K-12.

    Science.gov (United States)

    Reyes-Cortés, Ruth; Martínez-Peñafiel, Eva; Martínez-Pérez, Francisco; de la Garza, Mireya; Kameyama, Luis

    2012-12-01

    We have developed a direct and efficient strategy, based on a three-step method, to select bacterial cell-envelope mutants resistant to bacteriophage infection. Escherichia coli K-12 strain W3110 underwent classical transposon mutagenesis followed by replica plating and selection for mutants resistant to infection by coliphage mEp213. To verify that phage resistance was due to mutations in the cell envelope, we transformed host cells with the viral genome using electroporation and selected those in which virions were subsequently detected in the supernatant. Among the nine mutants resistant to coliphage infection that we selected, six were in the fhuA gene, two were mutated in the waaC gene, and one was mutated in the gmhD gene. The latter two gene products are involved in the synthesis of lipopolysaccharide (LPS). The efficiency of plating and adsorption of phage mEp213 was affected in these mutants. We verified that LPS is required for the efficient infection of phage λ as well. We propose that this mutation-and-selection strategy can be used to find host factors involved in the initial steps of phage infection for any cognate pair of phage and bacteria.

  1. 气相色谱/三重四极杆串联质谱法测定牛奶及奶粉中213种农药多残留%Determination of 213 pesticide residues in milk and milk power by gas chromatography-triple quadrupole tandem mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    王敬; 艾连峰; 马育松; 张海超; 李玮; 于猛

    2015-01-01

    On the basis of the optimization of solid phase extraction adsorbent,eluting solvent types and amounts,a gas chromatography-triple quadrupole tandem mass spectrometry( GC-MS/MS)method was established for the determination of 213 pesticide residues in milk and milk power. The samples were extracted by acetonitrile,cleaned-up with an ENVI-Carb/NH2 solid-phase extractant,and determined by GC-MS/MS using external standard method. The linear ranges were from 10 to 1 000 μg/L for 197 pesticides,from 50 to 1 000 μg/L for the other 16 pesticides with the correlation coefficients higher than 0. 99. The limits of detection( LODs, S/N=3)varied over the range of 0. 03 to 7. 59 μg/kg,and limits of quantification( LOQs,S/N=10)ranged from 0. 10 to 21. 94 μg/kg. The average recoveries in different matrices were in the range of 66. 9%-120. 1% with the relative standard deviations( RSDs ) of 1. 23%-17. 6%. This method is simple,rapid,sensitive and reliable for meeting the requirements for the simul-taneous identification and quantification of the multi-residues in milk and milk power.%在系统优化固相萃取吸附剂填料类型、洗脱溶剂种类及体积的基础上,建立了牛奶和奶粉中213种农药残留的气相色谱-三重四极杆串联质谱( GC-MS/MS)方法。试样用乙腈均质提取,采用石墨化炭黑/氨基柱( ENVI-Carb/NH2)净化后,用 GC-MS/MS多反应离子监测(MRM)模式进行检测,外标法定量。结果表明,197种农药在10~1000μg/L,16种农药在50~1000μg/L范围内线性关系良好,相关系数均大于0.99,方法的检出限( S/N=3)为0.03~7.59μg/kg,定量限( S/N=10)为0.10~21.94μg/kg,平均添加回收率为66.9%~120.1%,相对标准偏差( RSD)为1.23%~17.6%。该方法样品处理简单快速,相比其他多残留分析方法净化效果好,灵敏度和选择性高,适用于日常检测工作。

  2. The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study

    Directory of Open Access Journals (Sweden)

    Tracy Russell P

    2011-03-01

    Full Text Available Abstract Background Genetic risk factors might improve prediction of coronary events. Several variants at chromosome 9p21.3 have been widely reported to be associated with coronary heart disease (CHD in prospective and case-control studies. A variant of KIF6 (719Arg has also been reported to be associated with increased risk of CHD in large prospective studies, but not in case-control studies. We asked whether the addition of genetic information (the 9p21.3 or KIF6 variants or a well-established non-genetic risk factor (C-reactive protein [CRP] can improve risk prediction by the Framingham Risk Score (FRS in the Cardiovascular Health Study (CHS--a prospective observational study of risk factors for cardiovascular disease among > 5,000 participants aged 65 or older. Methods Improvement of risk prediction was assessed by change in the area under the receiver-operator characteristic curve (AUC and by net reclassification improvement (NRI. Results Among white participants the FRS was improved by addition of KIF6 719Arg carrier status among men as assessed by the AUC (from 0.581 to 0.596, P = 0.03 but not by NRI (NRI = 0.027, P = 0.32. Adding both CRP and 719Arg carrier status to the FRS improved risk prediction by the AUC (0.608, P = 0.02 and NRI (0.093, P = 0.008 in men, but not women (P ≥ 0.24. Conclusions While none of these risk markers individually or in combination improved risk prediction among women, a combination of KIF6 719Arg carrier status and CRP levels modestly improved risk prediction among white men; although this improvement is not significant after multiple-testing correction. These observations should be investigated in other prospective studies.

  3. Reply to “Reply to comments on defining biominerals and organominerals: Direct and indirect indicators of life [Perry et al., Sedimentary Geology, 201, 157–179]” by R.S. Perry and M.A. Sephton: [Sedimentary Geology 213 (2009) 156

    OpenAIRE

    Défarge, Christian; Gautret, Pascale; Reitner, Joachim; Trichet, Jean

    2010-01-01

    International audience This is a reply to R.S. Perry and M.A. Sephton's “Reply to comments on defining biominerals and organominerals: direct and indirect indicators of life [Perry et al., Sedimentary Geology, 201, 157–179]” [Sedimentary Geology 213 (2009) 156].

  4. 汶川地震中国道 G213左侧某典型高山河谷场地地震滑坡响应分析%ANALYSIS OF LANDSLIDE RESPONSES OF A TYPICAL HIGH HILL-RIVER VALLEY FIELD NEAR NATIONAL ROAD G213 DURING WENCHUAN EARTHQUAKE

    Institute of Scientific and Technical Information of China (English)

    杨长卫; 张建经

    2013-01-01

      以国道 G213左侧一处包含河谷地形的高陡边坡为原型,采用新型离散元计算方法——基于连续模型的离散元方法(CDEM),对高烈度地震作用下高陡边坡上的堆积体滑坡由变形累计到破坏滑动的全过程进行模拟,并结合振动台试验结果,对该高陡边坡上堆积体的地震滑坡响应进行研究。研究结果表明,在地震力和重力作用下,堆积体顶部先出现应力集中,造成堆积体沿基岩–堆积体结构面后缘产生变形,进而造成该处出现拉伸、剪切破坏点,之后随着地震动的持续,基岩–堆积体结构面上的剪切破坏点逐渐向堆积体中前部的锁固段扩展,同时伴随着堆积体表面拉伸破坏点的增加,最终造成锁固段发生渐进性破坏,堆积体从剪出口滑出形成滑坡。滑塌发生的时间与地震动峰值加速度到达的时间同步或稍微有所滞后。在高陡边坡地形中,以输入地震波为基准,不论是坡面还是坡体内,不同位置的峰值加速度沿坡高均有所放大,表现为竖向峰值加速度的放大效应>水平峰值加速度的放大效应,坡面峰值加速度的放大效应>坡体内峰值加速度的放大效应。在河谷地形中,以输入波为基准,不论是河床还是河岸两侧的斜坡,不同位置的峰值加速度沿高程均具有不同程度的放大;河谷对加速度放大效应的影响具有一定范围,且在该范围内水平加速度的放大效应>竖向加速度的放大效应,与坡面处加速度的放大效应刚好相反;加速度的放大效应具有一定的方向性,且该方向性与河岸两侧斜坡的坡度有关;加速度放大效应在河谷底部的分布具有不均匀性,距离河岸越近,加速度放大效应越强烈。%  A high steep hill with river valley near National Road G213 is used as a prototype. A full process from initial deformation to sliding of the

  5. 慢性胰腺炎CT影像解剖学分型及其临床意义%CT imaging-anatomy type of total 213 chronic pancreatitis and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    陈盛; 王卫东; 汪华侨

    2011-01-01

    Objective To explore CT imaging-anatomy type of chronic pancreatitis and their clinical significance based on the CT characteristics of chronic pancreatitis. Methods In total 213 cases of chronic pancreatitis patiernts , 156 males and 57 females, with an average age of 48.0±11.5 years old and an average hospital day of 18.4±9.2 days were enrolles in the study.History of bile duct disease and acute pancreatitis were positive in 68 patients (32%) and 36 patients (17%) respectively. Non contrast enhanced and contrast enhanced CT scans were performed (with range from liver to kidney artery level). Results 69 cases (32.4%) showed whole pancreas atrophic. Pancreatic pseudocyst was shown in 3lcases (14.5%). Pancreatic duct occlusion or dilated can be seen in 56 cases ( 26.3%). 18 cases (8.5%) for the mass type , showed local soft tissue samples of pancreatic tumors and 39 cases (18.3%) were mixed. appearance of dilated pancreatic duct or bile duct with pancreatic mass or pseudocyst etc.Conclusion The CT manifestations of chronic pancreatitis can be classified into 5 types: atrophy type, pancreatic pseudocyst type, pancreatic duct occlusion or dilatation type, mass type and mixed hybrid type. The classification had certain significance for the differential diagnosis and the etiological analysis of chronic pancreatitis.%目的 根据慢性胰腺炎CT表现的不同,探讨慢性胰腺炎的CT影像解剖学分型及分型的意义.方法收集1996年1月至2009年1月入住我院经临床或手术证实的213例慢性胰腺炎患者,其中男性156例,女性57例,平均年龄为(48.0±11.5)岁;平均住院天数(18.4±9.2)d;胆系疾病68例(32%),反复发作急性胰腺炎36例(17%).常规肝胆脾胰平扫加增强(肝至肾动脉水平).结果 213例慢性胰腺炎患者中,有69例(32.4%)表现为全胰腺萎缩型,31例(14.5%)表现为假性囊肿型,56例(26.3%)表现为胰管闭塞或扩张,18例(8.5%)表现局限性胰腺

  6. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    International Nuclear Information System (INIS)

    A technique of selenium purification from 232Th, 238U, 226,228Ra, 227Ac and 40K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  7. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  8. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  9. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  10. Linear free energy relationship applied to trivalent cations with lanthanum and actinium oxide and hydroxide structure

    International Nuclear Information System (INIS)

    Linear free energy relationships for trivalent cations with crystalline M2O3 and, M(OH)3 phases of lanthanides and actinides were developed from known thermodynamic properties of the aqueous trivalent cations, modifying the Sverjensky and Molling equation. The linear free energy relationship for trivalent cations is as ΔGf,MvX0=aMvXΔGn,M3+0+bMvX+βMvXrM3+, where the coefficients aMvX, bMvX, and βMvX characterize a particular structural family of MvX, rM3+ is the ionic radius of M3+ cation, ΔGf,MvX0 is the standard Gibbs free energy of formation of MvX and ΔGn,M3+0 is the standard non-solvation free energy of the cation. The coefficients for the oxide family are: aMvX=0.2705, bMvX=-1984.75 (kJ/mol), and βMvX=197.24 (kJ/molnm). The coefficients for the hydroxide family are: aMvX=0.1587, bMvX=-1474.09 (kJ/mol), and βMvX=791.70 (kJ/molnm).

  11. Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications

    OpenAIRE

    Kovatsch, Matthias; Lanter, Martin; Duquennoy, Simon

    2012-01-01

    Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that pr...

  12. Reflection asymmetry in odd-A and odd-odd actinium nuclei

    International Nuclear Information System (INIS)

    Theoretical calculations and measurements indicate that octupole correlations are at a maximum in the ground states of the odd-proton nuclei Ac and Pa. It has been expected that odd-odd nuclei should have even larger amount of octupole-octupole correlations. We have recently made measurements on the structure of 224Ac. Although spin and parity assignments could not be made, two bands starting at 354.1 and 360.0 keV have properties characteristic of reflection asymmetric shape. These two bands have very similar rotational constants and also similar alpha decay rates, which suggest similarity between the wavefunctions of these bands. These signatures provide evidence for octupole correlations in these nuclides

  13. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    OpenAIRE

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  14. The Treatment of EEG Biofeedback in 213 Cases of Childhood Attention Deficit Hyperactivity Disorder%脑电生物反馈治疗儿童注意缺陷多动障碍

    Institute of Scientific and Technical Information of China (English)

    张传杰; 刘丽娟; 赵峰; 李敬风

    2011-01-01

    目的:研究脑电生物反馈训练治疗儿童注意缺陷多动障碍(ADHD)的效果.方法:用VBFB3000脑电生物反馈诊疗系统对213例ADHD患儿进行治疗,采用视听整合测试报告(IVA-TP)评估其疗效.结果:治愈85例(39.9%),显效80例(37.6%),好转37例(17.3%),总有效率达94.8%.训练1疗程与2疗程疗效比较,除混合型疗效差异无统计学意义外(P>0.05),其它均有统计学意义(P0.05)外,其它型疗效差异均有统计学意义(P<0.05).结论:脑电生物反馈训练用于儿童ADHD治疗可行.%Objective To study the effects of EEG biofeedback training on treatment of childhood attention deficit hyperactivity disorder(ADHD).Methods Totally 213 cases of children diagnosed as ADHD were taken VBFB3000 EEG biofeedback training clinic system for 30 minutes each time, and 2 times every week.Every group children were taken 1 to 3 treatment courses,respectively.The report of audio-visual integration test (IVA-TP) was used for assessing the efficacy of EEG biofeedback training.Results The total effective rate was 94.8% ,among which 85 cases were healed(39.9% ) ,80 cases were in effect(37.6% ) ,37 cases were improved( 17.3% ).Compared the treament effects between training for 1 course and 2 courses,two of three ADHD types were significant difference excluding the mixing type ( P < 0.05) ;while compared the treament effects between training for 2 courses and 3 courses,two of three ADHD types were significant difference excluding the hyperactivity-impulse type(P < 0.05).Conclusion The EEG biofeedback training could be effectively used for ADHD treatment in children.

  15. NE-213-scintillator-based neutron detection system for diagnostic measurements of energy spectra for neutrons having energies greater than or equal to 0.8 MeV created during plasma operations at the Princeton Tokamak Fusion Test Reactor

    International Nuclear Information System (INIS)

    A system for making diagnostic measurements of the energy spectra of greater than or equal to 0.8-MeV neutrons produced during plasma operations of the Princeton Tokamak Fusion Test Reactor (TFTR) has been fabricated and tested and is presently in operation in the TFTR Test Cell Basement. The system consists of two separate detectors, each made up of cells containing liquid NE-213 scintillator attached permanently to RCA-8850 photomultiplier tubes. Pulses obtained from each photomultiplier system are amplified and electronically analyzed to identify and separate those pulses due to neutron-induced events in the detector from those due to photon-induced events in the detector. Signals from each detector are routed to two separate Analog-to-Digital Converters, and the resulting digitized information, representing: (1) the raw neutron-spectrum data; and (2) the raw photon-spectrum data, are transmited to the CICADA data-acquisition computer system of the TFTR. Software programs have been installed on the CICADA system to analyze the raw data to provide moderate-resolution recreations of the energy spectrum of the neutron and photon fluences incident on the detector during the operation of the TFTR. A complete description of, as well as the operation of, the hardware and software is given in this report

  16. Review of the methods used for leak rate measurements for WWER-440/230 confinements and WWER-440/213 containments. A publication of the extrabudgetary programme on the safety of WWER and RBMK nuclear power plants

    International Nuclear Information System (INIS)

    Program was initiated by IAEA in 1990 with the aim to assist the countries of Central and Eastern Europe and former Soviet Union in evaluating the safety of their first generation WWER-440/230 nuclear power plants. The main objectives were: to identify major design and operational safety issues; to establish international consensus on priorities for safety improvements; and to provide assistance in the review of the competence and and adequacy of safety improvement programs. The scope was extended in 1992 ro include RBMK, WWER-440/312 and WWER-1000 plants in operation and under construction. One of the characteristic features od confinements in WWER-440/213 reactors is their comparatively high leakage rate, ranging from several hundred per cent per day upwards, which is lower than those of WWER-440/230 but in both types of containments the task of leakage rate determination presents complex problems which do not appear in western type units. This report contains the requirements for containment leak rate testing and for integral test in the countries operating WWER reactors and comparison with the requirements in force in USA, Germany and France. It describes the leak rate testing principles and leak rate extrapolation methods, discusses in detail the differences in leakage rate definitions due to significant leakages in WWER containments and explains their consequences. The procedures for structural integrity tests of WWER-440 containments are described and recommendations given

  17. Modification, biological evaluation and 3D QSAR studies of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-ylphenol derivatives as inhibitors of B-Raf kinase.

    Directory of Open Access Journals (Sweden)

    Yu-Shun Yang

    Full Text Available A series of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-ylphenol derivatives (C1-C24 have been synthesized. The B-Raf inhibitory activity and anti-proliferation activity of these compounds have been tested. Compound C6 displayed the most potent biological activity against B-RafV600E (IC50 = 0.15 µM and WM266.4 human melanoma cell line (GI50 = 1.75 µM, being comparable with the positive control (Vemurafenib and Erlotinib and more potent than our previous best compounds. The docking simulation was performed to analyze the probable binding models and poses while the QSAR model was built to check the previous work as well as to introduce new directions. This work aimed at seeking more potent inhibitors as well as discussing some previous findings. As a result, the introduction of ortho-hydroxyl group on 4,5-dihydro-1H-pyrazole skeleton did reinforce the anti-tumor activity while enlarging the group on N-1 of pyrazoline was also helpful.

  18. Paleomagnetism of Basaltic Lava Flows in Coreholes ICPP 213, ICPP-214, ICPP-215, and USGS 128 Near the Vadose Zone Research Park, Idaho Nuclear Technology and Engineering Center, Idaho National Engineering and Environmental Laboratory, Idaho

    Science.gov (United States)

    Champion, Duane E.; Herman, Theodore C.

    2003-01-01

    A paleomagnetic study was conducted on basalt from 41 lava flows represented in about 2,300 ft of core from coreholes ICPP-213, ICPP-214, ICPP-215, and USGS 128. These wells are in the area of the Idaho Nuclear Technology and Engineering Center (INTEC) Vadose Zone Research Park within the Idaho National Engineering and Environmental Laboratory (INEEL). Paleomagnetic measurements were made on 508 samples from the four coreholes, which are compared to each other, and to surface outcrop paleomagnetic data. In general, subhorizontal lines of correlation exist between sediment layers and between basalt layers in the area of the new percolation ponds. Some of the basalt flows and flow sequences are strongly correlative at different depth intervals and represent important stratigraphic unifying elements. Some units pinch out, or thicken or thin even over short separation distances of about 1,500 ft. A more distant correlation of more than 1 mile to corehole USGS 128 is possible for several of the basalt flows, but at greater depth. This is probably due to the broad subsidence of the eastern Snake River Plain centered along its topographic axis located to the south of INEEL. This study shows this most clearly in the oldest portions of the cored sections that have differentially subsided the greatest amount.

  19. The Clinical Analysis of Turner syndrome%先天性卵巢发育不良综合征的临床分析(附213例报告)

    Institute of Scientific and Technical Information of China (English)

    江静; 付曼芬; 王伟; 陈凤生; 王德芬

    2003-01-01

    目的探讨先天性卵巢发育不良综合征(Turner)综合征的终身高、生长激素水平、学历和性发育的变化.方法 213例Turner综合征进行了染色体检查,57例生长激素激发试验,41例随访了学历和性发育.结果染色体核型分4组,第1组45,X,78例;第2组嵌合型60例;第3组X染色体结构畸变69例;第4组伴有Y染色体6例.终身高(139.1±8.3)cm.生长激素完全缺乏16例,部分缺乏30例,正常11例.随访41例中,学历大部分在初中、技校和中专,17例有不同程度的性发育,24例无性发育.结论 Turner征患者终身高明显低于正常人群,生长激素分泌低下,学习能力降低,性发育不全.

  20. Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors.

    Science.gov (United States)

    Yuan, Gengyang; Jones, Graham B; Vasdev, Neil; Liang, Steven H

    2016-10-01

    To prompt the development of (18)F-labeled positron emission tomography (PET) tracers for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, we have prepared (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile ([(18)F]8). The radiosynthesis was achieved by a one-pot two-step method that utilized a spirocyclic hypervalent iodine(III) mediated radiofluorination to prepare the (18)F-labeled 1-bromo-3-fluorobenzene ([(18)F]15) intermediate with K(18)F. A subsequent copper(I) iodide mediated coupling reaction was carried out with 2-(2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile (10) to [(18)F]8 in 10±2% uncorrected radiochemical yield relative to starting (18)F-fluoride with >99% radiochemical purity and 29.6±7.4Gbq/μmol specific activity at the time of injection. PET imaging studies with the title radiotracer in normal mice demonstrated good brain uptake (peak standardized uptake value (SUV)=2.3±0.1) and warrants further in vivo validation.

  1. A Genome Wide Study of Copy Number Variation Associated with Nasopharyngeal Carcinoma in Malaysian Chinese Identifies CNVs at 11q14.3 and 6p21.3 as Candidate Loci.

    Directory of Open Access Journals (Sweden)

    Joyce Siew Yong Low

    Full Text Available Nasopharyngeal carcinoma (NPC is a neoplasm of the epithelial lining of the nasopharynx. Despite various reports linking genomic variants to NPC predisposition, very few reports were done on copy number variations (CNV. CNV is an inherent structural variation that has been found to be involved in cancer predisposition.A discovery cohort of Malaysian Chinese descent (NPC patients, n = 140; Healthy controls, n = 256 were genotyped using Illumina® HumanOmniExpress BeadChip. PennCNV and cnvPartition calling algorithms were applied for CNV calling. Taqman CNV assays and digital PCR were used to validate CNV calls and replicate candidate copy number variant region (CNVR associations in a follow-up Malaysian Chinese (NPC cases, n = 465; and Healthy controls, n = 677 and Malay cohort (NPC cases, n = 114; Healthy controls, n = 124.Six putative CNVRs overlapping GRM5, MICA/HCP5/HCG26, LILRB3/LILRA6, DPY19L2, RNase3/RNase2 and GOLPH3 genes were jointly identified by PennCNV and cnvPartition. CNVs overlapping GRM5 and MICA/HCP5/HCG26 were subjected to further validation by Taqman CNV assays and digital PCR. Combined analysis in Malaysian Chinese cohort revealed a strong association at CNVR on chromosome 11q14.3 (Pcombined = 1.54x10-5; odds ratio (OR = 7.27; 95% CI = 2.96-17.88 overlapping GRM5 and a suggestive association at CNVR on chromosome 6p21.3 (Pcombined = 1.29x10-3; OR = 4.21; 95% CI = 1.75-10.11 overlapping MICA/HCP5/HCG26 genes.Our results demonstrated the association of CNVs towards NPC susceptibility, implicating a possible role of CNVs in NPC development.

  2. A Genome Wide Study of Copy Number Variation Associated with Nasopharyngeal Carcinoma in Malaysian Chinese Identifies CNVs at 11q14.3 and 6p21.3 as Candidate Loci

    Science.gov (United States)

    Low, Joyce Siew Yong; Chin, Yoon Ming; Mushiroda, Taisei; Kubo, Michiaki; Govindasamy, Gopala Krishnan; Pua, Kin Choo; Yap, Yoke Yeow; Yap, Lee Fah; Subramaniam, Selva Kumar; Ong, Cheng Ai; Tan, Tee Yong; Khoo, Alan Soo Beng; Ng, Ching Ching

    2016-01-01

    Background Nasopharyngeal carcinoma (NPC) is a neoplasm of the epithelial lining of the nasopharynx. Despite various reports linking genomic variants to NPC predisposition, very few reports were done on copy number variations (CNV). CNV is an inherent structural variation that has been found to be involved in cancer predisposition. Methods A discovery cohort of Malaysian Chinese descent (NPC patients, n = 140; Healthy controls, n = 256) were genotyped using Illumina® HumanOmniExpress BeadChip. PennCNV and cnvPartition calling algorithms were applied for CNV calling. Taqman CNV assays and digital PCR were used to validate CNV calls and replicate candidate copy number variant region (CNVR) associations in a follow-up Malaysian Chinese (NPC cases, n = 465; and Healthy controls, n = 677) and Malay cohort (NPC cases, n = 114; Healthy controls, n = 124). Results Six putative CNVRs overlapping GRM5, MICA/HCP5/HCG26, LILRB3/LILRA6, DPY19L2, RNase3/RNase2 and GOLPH3 genes were jointly identified by PennCNV and cnvPartition. CNVs overlapping GRM5 and MICA/HCP5/HCG26 were subjected to further validation by Taqman CNV assays and digital PCR. Combined analysis in Malaysian Chinese cohort revealed a strong association at CNVR on chromosome 11q14.3 (Pcombined = 1.54x10-5; odds ratio (OR) = 7.27; 95% CI = 2.96–17.88) overlapping GRM5 and a suggestive association at CNVR on chromosome 6p21.3 (Pcombined = 1.29x10-3; OR = 4.21; 95% CI = 1.75–10.11) overlapping MICA/HCP5/HCG26 genes. Conclusion Our results demonstrated the association of CNVs towards NPC susceptibility, implicating a possible role of CNVs in NPC development. PMID:26730743

  3. Fungal Planet description sheets: 154-213.

    Science.gov (United States)

    Crous, P W; Wingfield, M J; Guarro, J; Cheewangkoon, R; van der Bank, M; Swart, W J; Stchigel, A M; Cano-Lira, J F; Roux, J; Madrid, H; Damm, U; Wood, A R; Shuttleworth, L A; Hodges, C S; Munster, M; de Jesús Yáñez-Morales, M; Zúñiga-Estrada, L; Cruywagen, E M; de Hoog, G S; Silvera, C; Najafzadeh, J; Davison, E M; Davison, P J N; Barrett, M D; Barrett, R L; Manamgoda, D S; Minnis, A M; Kleczewski, N M; Flory, S L; Castlebury, L A; Clay, K; Hyde, K D; Maússe-Sitoe, S N D; Chen, Shuaifei; Lechat, C; Hairaud, M; Lesage-Meessen, L; Pawłowska, J; Wilk, M; Sliwińska-Wyrzychowska, A; Mętrak, M; Wrzosek, M; Pavlic-Zupanc, D; Maleme, H M; Slippers, B; Mac Cormack, W P; Archuby, D I; Grünwald, N J; Tellería, M T; Dueñas, M; Martín, M P; Marincowitz, S; de Beer, Z W; Perez, C A; Gené, J; Marin-Felix, Y; Groenewald, J Z

    2013-12-01

    Novel species of microfungi described in the present study include the following from South Africa: Camarosporium aloes, Phaeococcomyces aloes and Phoma aloes from Aloe, C. psoraleae, Diaporthe psoraleae and D. psoraleae-pinnatae from Psoralea, Colletotrichum euphorbiae from Euphorbia, Coniothyrium prosopidis and Peyronellaea prosopidis from Prosopis, Diaporthe cassines from Cassine, D. diospyricola from Diospyros, Diaporthe maytenicola from Maytenus, Harknessia proteae from Protea, Neofusicoccum ursorum and N. cryptoaustrale from Eucalyptus, Ochrocladosporium adansoniae from Adansonia, Pilidium pseudoconcavum from Greyia radlkoferi, Stagonospora pseudopaludosa from Phragmites and Toxicocladosporium ficiniae from Ficinia. Several species were also described from Thailand, namely: Chaetopsina pini and C. pinicola from Pinus spp., Myrmecridium thailandicum from reed litter, Passalora pseudotithoniae from Tithonia, Pallidocercospora ventilago from Ventilago, Pyricularia bothriochloae from Bothriochloa and Sphaerulina rhododendricola from Rhododendron. Novelties from Spain include Cladophialophora multiseptata, Knufia tsunedae and Pleuroascus rectipilus from soil and Cyphellophora catalaunica from river sediments. Species from the USA include Bipolaris drechsleri from Microstegium, Calonectria blephiliae from Blephilia, Kellermania macrospora (epitype) and K. pseudoyuccigena from Yucca. Three new species are described from Mexico, namely Neophaeosphaeria agaves and K. agaves from Agave and Phytophthora ipomoeae from Ipomoea. Other African species include Calonectria mossambicensis from Eucalyptus (Mozambique), Harzia cameroonensis from an unknown creeper (Cameroon), Mastigosporella anisophylleae from Anisophyllea (Zambia) and Teratosphaeria terminaliae from Terminalia (Zimbabwe). Species from Europe include Auxarthron longisporum from forest soil (Portugal), Discosia pseudoartocreas from Tilia (Austria), Paraconiothyrium polonense and P. lycopodinum from Lycopodium (Poland) and Stachybotrys oleronensis from Iris (France). Two species of Chrysosporium are described from Antarctica, namely C. magnasporum and C. oceanitesii. Finally, Licea xanthospora is described from Australia, Hypochnicium huinayensis from Chile and Custingophora blanchettei from Uruguay. Novel genera of Ascomycetes include Neomycosphaerella from Pseudopentameris macrantha (South Africa), and Paramycosphaerella from Brachystegia sp. (Zimbabwe). Novel hyphomycete genera include Pseudocatenomycopsis from Rothmannia (Zambia), Neopseudocercospora from Terminalia (Zambia) and Neodeightoniella from Phragmites (South Africa), while Dimorphiopsis from Brachystegia (Zambia) represents a novel coelomycetous genus. Furthermore, Alanphillipsia is introduced as a new genus in the Botryosphaeriaceae with four species, A. aloes, A. aloeigena and A. aloetica from Aloe spp. and A. euphorbiae from Euphorbia sp. (South Africa). A new combination is also proposed for Brachysporium torulosum (Deightoniella black tip of banana) as Corynespora torulosa. Morphological and culture characteristics along with ITS DNA barcodes are provided for all taxa. PMID:24761043

  4. Fungal Planet description sheets: 154-213

    OpenAIRE

    Crous, P.W.; Wingfield, M.J.; Guarro, J; Cheewangkoon, R.; Bank, van der, M.; Swart, W J; Stchigel, A. M.; Cano-Lira, J.F.; Roux, J.; Madrid, H.; Damm, U.; Wood, A. R.; Shuttleworth, L.A.; Hodges, C.S.; Munster, M.

    2013-01-01

    Novel species of microfungi described in the present study include the following from South Africa: Camarosporium aloes, Phaeococcomyces aloes and Phoma aloes from Aloe, C. psoraleae, Diaporthe psoraleae and D. psoraleae-pinnatae from Psoralea, Colletotrichum euphorbiae from Euphorbia, Coniothyrium prosopidis and Peyronellaea prosopidis from Prosopis, Diaporthe cassines from Cassine, D. diospyricola from Diospyros, Diaporthe maytenicola from Maytenus, Harknessia proteae from Protea, Neofusico...

  5. 14 CFR 61.213 - Eligibility requirements.

    Science.gov (United States)

    2010-01-01

    ...) Be at least 18 years of age; (2) Be able to read, write, speak, and understand the English language... fundamentals of instructing to include— (i) The learning process; (ii) Elements of effective teaching;...

  6. 22 CFR 213.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... withholdings; health insurance premiums; retirement contributions; and life insurance premiums. (j) Employee... garnishment orders) in accordance with 5 CFR parts 581 and 582. Among the legally required deductions that... (Title 26, United States Code) and deductions described in 5 CFR 581.105 (b) through (f)....

  7. SU-B-213-01: Introduction

    International Nuclear Information System (INIS)

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP

  8. 47 CFR 90.213 - Frequency stability.

    Science.gov (United States)

    2010-10-01

    ... maintained within 50 Hz of the authorized carrier frequency. 3 Travelers information station transmitters... 25-50 20 20 50 72-76 5 50 150-174 5,11 5 6 5 4,6 50 216-220 1.0 1.0 220-222 12 0.1 1.5 1.5 421-512 7... must have a frequency stability of 50 ppm except for equipment used in the Public Safety Pool where...

  9. Fungal Planet description sheets: 154–213

    NARCIS (Netherlands)

    Crous, P.W.; Wingfield, M.J.; Guarro, J.; Cheewangkoon, R.; Bank, van der M.; Swart, W.J.; Stchigel, A.M.; Cano-Lira, J.F.; Roux, J.; Madrid, H.; Damm, U.; Wood, A.R.; Shuttleworth, L.A.; Hodges, C.S.; Munster, M.; Jesús Yáñez-Morales, de M.; Zúñiga-Estrada, L.; Cruywagen, E.M.; Hoog, de G.S.; Silvera, C.; Najafzadeh, J.; Davison, E.M.; Davison, P.J.N.; Barrett, M.D.; Barrett, R.L.; Manamgoda, D.S.; Minnis, A.M.; Kleczewski, N.M.; Flory, S.L.; Castlebury, L.A.; Clay, K.; Hyde, K.D.; Maússe-Sitoe, S.N.D.; Chen, S.; Lechat, C.; Hairaud, M.; Lesage-Meessen, L.; Pawlowska, J.; Wilk, M.; Sliwinska-Wyrzychowska, A.; Metrak, M.; Wrzosek, M.; Pavlic-Zupanc, D.; Maleme, H.M.; Slippers, B.; Mac Cormack, W.P.; Archuby, D.I.; Grünwald, N.J.; Tellería, M.T.; Dueñas, M.; Martín, M.P.; Marincowitz, S.; Beer, de Z.W.; Perez, C.A.; Gené, J.; Marin-Felix, Y.; Groenewald, J.Z.

    2013-01-01

    Novel species of microfungi described in the present study include the following from South Africa: Camarosporium aloes, Phaeococcomyces aloes and Phoma aloes from Aloe, C. psoraleae, Diaporthe psoraleae and D. psoraleae-pinnatae from Psoralea, Colletotrichum euphorbiae from Euphorbia, Coniothyrium

  10. 12 CFR 213.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... does not include a lease that meets the definition of a credit sale in Regulation Z (12 CFR 226.2(a... Truth in Lending Act. (b) Advertisement means a commercial message in any medium that directly or... personal property by a natural person primarily for personal, family, or household purposes, for a...

  11. 50 CFR 21.3 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... means the Army, Navy, Air Force, Marine Corps, Coast Guard, and the National Guard of any State. Bred in... viable” when its ability to maintain its genetic diversity, to reproduce, and to function effectively...

  12. 49 CFR 213.337 - Defective rails.

    Science.gov (United States)

    2010-10-01

    ... through it. A crack or rust streak may show under the head close to the web or pieces may be split off the... weld means a field or plant weld containing any discontinuities or pockets, exceeding 5 percent of...

  13. 49 CFR 213.113 - Defective rails.

    Science.gov (United States)

    2010-10-01

    ... head, and extending into or through it. A crack or rust streak may show under the head close to the web... reported as separate defects. (14) Defective weld means a field or plant weld containing...

  14. 22 CFR 213.5 - Fraud claims.

    Science.gov (United States)

    2010-04-01

    ... of the debtor or any party having an interest in the claim to the USAID Office of Inspector General... the Department of Justice (DOJ), and/or returning it to the CFO for further action. (b) The CFO will... presentation of a false claim or misrepresentation on the part of the debtor or any party having an interest...

  15. 49 CFR 180.213 - Requalification markings.

    Science.gov (United States)

    2010-10-01

    ... provided that— (A) Permission is obtained from the cylinder owner; (B) The minimum wall thickness is... the letters “AE” for acoustic emission or “UE” for ultrasonic examination. (9) For designation of...

  16. 19 CFR 213.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ..., partnership, corporation, joint venture, trade or other association, cooperative, group of workers, or... 1974 (19 U.S.C. 2411 et seq., relating to relief from foreign import restrictions and export subsidies... trade law relating to relief from foreign import restrictions and export subsidies is administered...

  17. Effects of Electromagnetic Fields on Fish and Invertebrates: Task 2.1.3: Effects on Aquatic Organisms - Fiscal Year 2011 Progress Report - Environmental Effects of Marine and Hydrokinetic Energy

    Energy Technology Data Exchange (ETDEWEB)

    Woodruff, Dana L.; Schultz, Irvin R.; Marshall, Kathryn E.; Ward, Jeffrey A.; Cullinan, Valerie I.

    2012-05-01

    This fiscal year (FY) 2011 progress report (Task 2.1.3 Effects on Aquatic Organisms, Subtask 2.3.1.1 Electromagnetic Fields) describes studies conducted by PNNL as part of the DOE Wind and Water Power Program to examine the potential effects of electromagnetic fields (EMF) from marine and hydrokinetic devices on aquatic organisms, including freshwater and marine fish and marine invertebrates. In this report, we provide a description of the methods and results of experiments conducted in FY 2010-FY 2011 to evaluate potential responses of selected aquatic organisms. Preliminary EMF laboratory experiments during FY 2010 and 2011 entailed exposures with representative fish and invertebrate species including juvenile coho salmon (Oncorhynchus kisutch), Atlantic halibut (Hippoglossus hippoglossus), California halibut (Paralicthys californicus), rainbow trout (Oncorhynchus mykiss), and Dungeness crab (Metacarcinus magister). These species were selected for their ecological, commercial, and/or recreational importance, as well as their potential to encounter an MHK device or transmission cable during part or all of their life cycle. Based on previous studies, acute effects such as mortality were not expected to occur from EMF exposures. Therefore, our measurement endpoints focused on behavioral responses (e.g., detection of EMF, interference with feeding behavior, avoidance or attraction to EMF), developmental changes (i.e., growth and survival from egg or larval stage to juvenile), and exposure markers indicative of physiological responses to stress. EMF intensities during the various tests ranged from 0.1 to 3 millitesla, representing a range of upper bounding conditions reported in the literature. Experiments to date have shown there is little evidence to indicate distinct or extreme behavioral responses in the presence of elevated EMF for the species tested. Several developmental and physiological responses were observed in the fish exposures, although most were not

  18. RISKAUDIT Report no. 7, Vol. 1: Safety evaluation of VVER 440/213 and VVER 1000/320 reactors in Rovno NPP Units 1, 2 and 3. Final Report by AIB-Vincotte Nuclear, CIEMAT, ANPA, GRS, IPSN, AEA-T

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-07-15

    The Riskaudit 7 report has been made by a group of independent experts from Western European countries representing technical organizations specialized in the support of regulatory bodies of those countries. It represents a preliminary estimation of the Ukrainian WWER B 213 and B 320 reactors, based on the example of Rovno NPP, analysed with a Western practice. The first part of the document covers the following aspects of the report: core design and fuel management; pressurized components; electrical supply; instrumentation and control; containment; internal events; site conditions and external events.

  19. RISKAUDIT Report no. 7, Vol. 2: Safety evaluation of VVER 440/213 and VVER 1000/320 reactors in Rovno NPP Units 1, 2 and 3. Final Report by AIB-Vincotte Nuclear, CIEMAT, ANPA, GRS, IPSN, AEA-T

    International Nuclear Information System (INIS)

    The Riskaudit 7 report has been made by a group of independent experts from Western European countries representing technical organizations specialized in the support of regulatory bodies of those countries. It represents a preliminary estimation of the Ukrainian WWER B 213 and B 320 reactors, based on the example of Rovno NPP, analysed with a Western practice. The second part of the document covers the following aspects of the report: accident analysis; systems analysis; plant operation; operating experience feedback; radio protection and health; probabilistic safety assessment; summary and future plans

  20. RISKAUDIT Report no. 7, Vol. 1: Safety evaluation of VVER 440/213 and VVER 1000/320 reactors in Rovno NPP Units 1, 2 and 3. Final Report by AIB-Vincotte Nuclear, CIEMAT, ANPA, GRS, IPSN, AEA-T

    International Nuclear Information System (INIS)

    The Riskaudit 7 report has been made by a group of independent experts from Western European countries representing technical organizations specialized in the support of regulatory bodies of those countries. It represents a preliminary estimation of the Ukrainian WWER B 213 and B 320 reactors, based on the example of Rovno NPP, analysed with a Western practice. The first part of the document covers the following aspects of the report: core design and fuel management; pressurized components; electrical supply; instrumentation and control; containment; internal events; site conditions and external events

  1. RISKAUDIT Report no. 7, Vol. 2: Safety evaluation of VVER 440/213 and VVER 1000/320 reactors in Rovno NPP Units 1, 2 and 3. Final Report by AIB-Vincotte Nuclear, CIEMAT, ANPA, GRS, IPSN, AEA-T

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-07-15

    The Riskaudit 7 report has been made by a group of independent experts from Western European countries representing technical organizations specialized in the support of regulatory bodies of those countries. It represents a preliminary estimation of the Ukrainian WWER B 213 and B 320 reactors, based on the example of Rovno NPP, analysed with a Western practice. The second part of the document covers the following aspects of the report: accident analysis; systems analysis; plant operation; operating experience feedback; radio protection and health; probabilistic safety assessment; summary and future plans.

  2. Rolls-Royce successful modernization of safety-critical Instrumentation and Control (I and C) equipment at the Dukovany VVER 440/213 Nuclear Power Plant, based on SPINLINE 3 platform

    International Nuclear Information System (INIS)

    Rolls-Royce has provided on-time delivery of a substantial safety-critical I and C overhaul for four Nuclear reactors operated by Czech Republic utility, CEZ a.s. This nine-year project is considered to be one of the largest I and C modernization projects in the world. The Dukovany VVER 440 I and C modernization project and its key success factors are profiled in this paper. The project is in the final stages with the last unit to be completed in 2009. Beginning in September 2000, the project is in compliance with the initial schedule. Rolls-Royce has been designing and manufacturing I and C solutions dedicated to the implementation of safety and safety-related functions in nuclear power plants (NPPs) for more than 30 years. Though the early solutions were non-software-based, since 1984 software-based solutions for safety I and C functions have been deployed in operating NPPs across France and 15 other countries. The Rolls-Royce platform is suitable for implementation of safety I and C functions in new NPPs, as well as in the modernization of safety equipment in existing plants. CEZ a.s. is a major electricity supplier for the national grid. At Dukovany, CEZ a.s. operates four units of VVER-440/213-type reactors producing one quarter of CEZ a.s. electricity production. The first of these units was connected to the grid in 1985. Since the year 2000, the nine-year modernization program has been underway at Dukovany, at a cost of more than 200 million Euros. The equipment replacement was implemented during regular, planned outages of the original equipment and systems. After an international bidding phase, CEZ a.s. awarded a contract to Skoda JS for general engineering and project management. Individual subcontracts were then signed between Skoda JS and a consortium between Rolls-Royce and Areva for modernization of the safety systems, including the Reactor Protection System (RPS), the Reactor Control System (RCS), and the Post-Accident Monitoring System (PAMS). Two

  3. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  4. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  5. A novel acquired cryptic three-way translocation t(2;11;5)(p21.3;q13.5;q23.2) with a submicroscopic deletion at 11p14.3 in an adult with hypereosinophilic syndrome.

    Science.gov (United States)

    Kjeldsen, Eigil

    2015-08-01

    Hypereosinophilic syndrome (HES) is a clinically and pathologically heterogeneous disease entity. It is characterized by persistent eosinophilia and organ damage after excluding other causes. Clonal eosinophilia is distinguished from idiopathic eosinophilia by the presence of histologic, cytogenetic, or molecular evidence of an underlying malignancy. There are two distinct subcategories of clonal eosinophilia: chronic eosinophilic leukemia, not otherwise specified and myeloid/lymphoid neoplasms with eosinophilia and mutations involving platelet-derived growth factor receptor α/β or fibroblast growth factor receptor 1. More than 50% of HES are without knowledge of underlying pathogenic molecular pathways. Here we examined a HES patient by oligo-based aCGH analysis and molecular cytogenetic methods. Examination for the common eosinophilia-related cytogenetic abnormalities involving the genes PDGFRA, PDGFRB, and FGFR1 together with BCR-ABL fusion gene was negative. Cytogenetic analysis and multi-color FISH analysis revealed a novel cryptic three-way translocation t(2;11;5)(p21.3;q13.5;q23.2). By oaCGH analysis we could not find any copy number changes related to the cytogenetic breakpoints but instead detected a 0.9Mb submicroscopic deletion at 11p14.3. The deleted region involved the 5'-upstream sequences and exons 1-4 of the LUZP2 gene, which encodes a leucine zipper protein. Analysis of surrogate germ-line cells revealed a normal result showing that the detected chromosomal aberrations were acquired. This is the first report on a HES patient associated with a novel complex three-way translocation t(2;11;5)(p21.3;q13.5;q23.2) and a submicroscopic deletion in chromosome band 11p14.3. The study also demonstrates the benefits of oligo-based aCGH analysis in detecting hidden disease related chromosomal abnormalities. The present findings provide additional clues to unravel important molecular pathways in HES to obtain the full spectrum of acquired chromosomal and

  6. 优质抗寒红茶新品种——潇湘红21—3选育研究报告%The Breeding of New Anti-cold Black Tea Cultivar--Xiao Xiang Hong 21-3

    Institute of Scientific and Technical Information of China (English)

    李赛君; 郑红发; 罗意; 康彦凯; 董丽娟

    2012-01-01

    江华苦茶是我省茶树珍贵资源,产于南岭山脉,制红茶香气浓郁,滋味浓强,冷后呈乳状,叶底红亮,红碎茶达二套样水平。抗寒性强,耐-9℃低温,可在长江中下游茶区种植。我所上世纪八十年代初在江华苦茶性状分离圃中进行优中选优,通过系统选育程序,选育出优质抗寒红茶新品种——潇湘红21—3(后简称21—3)。%Jianghua Bitter Tea is a rare breeding resource, which grows in Nanling Mountains of Hunan. The black tea made by Jianghua Bitter Tea is strong in flavor and taste, the brewing would cool down, and the brewed leaf is red and bright. Its Black Broken Tea quality can reach the level of 2nd Samples. It can stand cold above -9 ℃, and grows in the lower Yangtze Region. Hunan Tea Research Institute had conducted breeding of Jianghua Bitter Tea in 1980's. Based on the work, anti-cold black tea cultivar Xiao Xiang Hong 21-3 was invented.

  7. Determination of l-tryptophan and l-kynurenine derivatized with (R)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole by LC-MS/MS on a triazole-bonded column and their quantification in human serum.

    Science.gov (United States)

    Takahashi, Shuuhei; Iizuka, Hideaki; Kuwabara, Ryousuke; Naito, Yoko; Sakamoto, Tatsuya; Miyagi, Aya; Onozato, Mayu; Ichiba, Hideaki; Fukushima, Takeshi

    2016-09-01

    The concentrations of l-tryptophan (Trp) and the metabolite l-kynurenine (KYN) can be used to evaluate the in-vivo activity of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO). As such, a novel method involving derivatization of l-Trp and l-KYN with (R)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole (DBD-PyNCS) and separation by high-performance liquid chromatography (HPLC) with tandem mass spectrometric (MS/MS) detection on a triazole-bonded column (Cosmosil HILIC®) was developed to determine their concentrations. The optimized mobile phase, CH3 CN/10 mm ammonium formate in H2 O (pH 5.0) (90:10, v/v) eluted isocratically, resulted in satisfactory separation and MS/MS detection of the analytes. The detection limits of l-Trp and l-KYN were approximately 50 and 4.0 pm, respectively. The column temperature affected the retention behaviour of the Trp and KYN derivatives, with increased column temperatures leading to increased capacity factors; positive enthalpy changes were revealed by van't Hoff plot analyses. Using the proposed LC-MS/MS method, l-Trp and l-KYN were successfully determined in 10 μL human serum using 1-methyl-l-Trp as an internal standard. The precision and recovery of l-Trp were in the ranges 2.85-9.29 and 95.8-113%, respectively, while those of l-KYN were 2.51-16.0 and 80.8-98.2%, respectively. The proposed LC-MS/MS method will be useful for evaluating the in vivo activity of IDO or TDO. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26910189

  8. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  9. 46 CFR 10.213 - National Driver Register.

    Science.gov (United States)

    2010-10-01

    ... pending the completion of the evaluation and delivery by the individual of the underlying State records... rehabilitation or counseling group, such as Alcoholics Anonymous or Narcotics Anonymous; (3) Character...

  10. 29 CFR 825.213 - Employer recovery of benefit costs.

    Science.gov (United States)

    2010-07-01

    ... employee's spouse is unexpectedly transferred to a job location more than 75 miles from the employee's... through deduction from any sums due to the employee (e.g., unpaid wages, vacation pay, profit sharing,...

  11. 50 CFR 226.213 - Critical habitat for Johnson's seagrass.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Critical habitat for Johnson's seagrass... Critical habitat for Johnson's seagrass. Critical habitat is designated to include substrate and water in... Johnson's seagrass. (a) A portion of the Indian River, Florida, north of Sebastian Inlet Channel,...

  12. 18 CFR 157.213 - Underground storage field facilities.

    Science.gov (United States)

    2010-04-01

    ... pressure, reservoir and buffer boundaries, and certificated capacity remain unchanged—and provided compliance with environmental and safety provisions is not affected. The certificate holder must not alter... pressure, reservoir and buffer boundaries, and certificated capacity remain unchanged—and...

  13. 40 CFR 180.213 - Simazine; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... Cherry 0.25 Corn, field, forage 0.20 Corn, field, grain 0.20 Corn, field, stover 0.25 Corn, pop, grain 0.20 Corn, pop, stover 0.25 Corn, sweet, forage 0.20 Corn, sweet, kernel plus cob with husks removed 0.25 Corn, sweet, stover 0.25 Cranberry 0.25 Currant 0.25 Egg 0.03 Goat, meat 0.03 Goat,...

  14. 46 CFR 109.213 - Emergency training and drills.

    Science.gov (United States)

    2010-10-01

    ... instruction using the on board training aids. Additionally, members of the crew or industrial personnel.... Abandonment training material must be on board each unit. The training material must consist either of a... to each person on board the unit. If audiovisual training aids are used, they must be...

  15. 12 CFR 213.3 - General disclosure requirements.

    Science.gov (United States)

    2010-01-01

    ... consumer consent and other applicable provisions of the Electronic Signatures in Global and National... scheduled payments may be different because a scheduled date is not a business day; (3) That months...

  16. 76 FR 213 - National Environmental Policy Act Implementing Procedures

    Science.gov (United States)

    2011-01-03

    ... FR 68720) seeking suggestions from interested parties. Eleven entities responded to the Request for... appear in appendix B) address: Stormwater runoff control; lead-based paint removal; recycling stations...-10 acres of land might not be considered ``small'' in an urban environment. In some...

  17. 49 CFR 213.57 - Curves; elevation and speed limitations.

    Science.gov (United States)

    2010-10-01

    ..., including schematic diagrams of the suspension systems and the location of the center of gravity above top... maintenance of the suspension system for the particular class of equipment; and (iv) Identification of line... an instrumented car having dynamic response characteristics that are representative of...

  18. 20 CFR 410.213 - Duration of entitlement; child.

    Science.gov (United States)

    2010-04-01

    ... first occurs: (1) The child dies; (2) The child marries; (3) The child attains age 18 and, (i) Is not... the month in which he attains age 18; (4) If the child's entitlement is based on his status as a... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Duration of entitlement; child....

  19. 49 CFR 213.110 - Gage restraint measurement systems.

    Science.gov (United States)

    2010-10-01

    ...). c=Coefficient of friction between rail/tie which is assigned a nominal value of (0.4). V=Actual... correlation between measurements made on the ground and those recorded by the instrumentation with respect to... the PTLF. PLG24 58 inches GWR 0.75 inches 1 Definitions for the GRMS parameters referenced in...

  20. 38 CFR 3.213 - Change of status affecting entitlement.

    Science.gov (United States)

    2010-07-01

    ...; (iv) Of divorce or death of a spouse. (b) Date not reported. If the month and year of the event is not... of receipt of a new claim. (c) Contradictory information. Where there is reason to believe that...

  1. 40 CFR 21.3 - Submission of applications.

    Science.gov (United States)

    2010-07-01

    ...) Additionally, if the applicant has received from a State Water Pollution Control Agency a permit issued by the...., 70 Dallas, TX 75201 Arkansas, Louisiana, New Mexico, Oklahoma, and Texas. VII Regional Administrator... assumed by the State may be obtained from either the appropriate Regional Administrator or the State...

  2. SU-B-213-03: Evaluation of Graduate Programs

    International Nuclear Information System (INIS)

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP

  3. SU-B-213-04: Evaluation of Residency Programs

    International Nuclear Information System (INIS)

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP

  4. SU-B-213-07: Panel Discussion

    International Nuclear Information System (INIS)

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP

  5. SU-B-213-02: Development of CAMPEP Standards

    International Nuclear Information System (INIS)

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP

  6. 49 CFR 213.333 - Automated vehicle inspection systems.

    Science.gov (United States)

    2010-10-01

    ... inspections to continuously compare loaded track gage to unloaded gage under a known loading condition. The... with a minimum cut-off frequency of 25 Hz. The sample rate for wheel force data shall be at least 250... feet away from the contact point of wheels carrying a vertical load of no less than 10,000 pounds...

  7. Dicty_cDB: VSD213 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available NCE, 1 ordered piece. 46 0.95 1 BQ476622 |BQ476622.1 curculio3e06.g Curculio glandium cDNA Curculio glandium cDNA clone curculio...3e06 3', mRNA sequence. 46 0.95 1 BQ476340 |BQ476340.1 curculio3e06.b Curculio glandium ...cDNA Curculio glandium cDNA clone curculio3e06 5', mRNA sequence. 46 0.95 1 AP004

  8. Dicty_cDB: AFA213 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available te sequence, segment 1/2. 60 1e-08 4 BM493927 |BM493927.1 NXLV_071_F02_F NXLV (Nsf Xylem Late wood Vertical)... Pinus taeda cDNA clone NXLV_071_F02 5', mRNA sequence. 50 5e-08 2 BQ634402 |BQ634402.1 NXRV068_E06_F NXRV (Nsf Xylem Root wood Verti...cal) Pinus taeda cDNA clone NXRV068_E06 5', mRNA sequence. 50 6e-08 2 BI416760 |BI4

  9. 19 CFR 10.213 - Articles eligible for preferential treatment.

    Science.gov (United States)

    2010-04-01

    ... limit published in the Federal Register pursuant to U.S. Note 2, Subchapter XIX, Chapter 98, HTSUS; (5... the articles, subject to the applicable quantitative limit published in the Federal Register pursuant... States; (10) A handloomed, handmade, or folklore article of a beneficiary country or countries that...

  10. Stabilised electromagnetic levitation at 2-13 MHz

    Science.gov (United States)

    Danley, T. J.; Schiffman, R. A.; Weber, J. K. R.; Krishnan, S.; Rey, C. A.; Bruno, P. A.; Nordine, P. C.

    1991-01-01

    SEL, the Stabilised Electromagnetic Levitator, has been developed to exploit the unique design opportunities available in containerless microgravity experiments. Efficiency and versatility are obtained with multiple coils driven by individual broadband amplifiers whose phase and frequency are controlled. The heating and positioning fields are decoupled. Specimen translation, spin, and for liquids, shape may be adjusted. An open coil structure provides access for optical and diagnostic probes. Results of experiments with a prototype device are discussed. Levitating and heating materials on earth were demonstrated at frequencies up to 13 MHz.

  11. 2-(1,3-Benzoxazol-2-ylsulfanyl-1-phenylethanone

    Directory of Open Access Journals (Sweden)

    Hossein Loghmani-Khouzani

    2009-09-01

    Full Text Available In the title compound, C15H11NO2S, a new thio-benzoxazole derivative, the dihedral angle between the benzoxazole ring and the phenyl ring is 9.91 (9°. An interesting feature of the crystal structure is the short C...S [3.4858 (17 Å] contact, which is shorter than the sum of the van der Waals radii of these atoms. In the crystal structure, molecules are linked together by zigzag intermolecular C—H...N interactions into a column along the a axis. The crystal structure is further stabilized by intermolecular π–π interactions [centroid–centroid = 3.8048 (10 Å].

  12. 2-(1,3-Benzoxazol-2-ylguanidinium chloride

    Directory of Open Access Journals (Sweden)

    Shaaban K. Mohamed

    2011-11-01

    Full Text Available The non-H atoms of the cation of the title salt, C8H9N4O+·Cl−, are approximately co-planar (r.m.s. deviation = 0.024 Å with one amino group forming an intramolecular hydrogen bond to the tertiary N atom of the benzoxazole fused-ring system. The cations and anions are linked by cyclic R21(6 N—H...Cl hydrogen-bonding associations, generating linear chains running along the a-axis direction.

  13. 48 CFR 52.213-1 - Fast Payment Procedure.

    Science.gov (United States)

    2010-10-01

    ....” Invoices not prominently marked “FAST PAY” via manual or electronic means may be accepted by the payment... (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52... carrier. (2) Notwithstanding any other provision of the contract, order, or blanket purchase...

  14. Dicty_cDB: VFI213 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |CF828170.1 UCRCR01_01C19_f Clementine Mandarin Albedo at Rind Separation cDNA L....1 UCRCR01_05N10_r Clementine Mandarin Albedo at Rind Separation cDNA Library Citrus reticulata cDNA clone C...R_CEa05N10, mRNA sequence. 54 0.004 1 CF828247 |CF828247.1 UCRCR01_01E19_f Clementine Mandarin Albedo at Rind Separation

  15. 5 CFR 213.3202 - Entire executive civil service.

    Science.gov (United States)

    2010-01-01

    ... performance appraisal program established under an approved performance appraisal system. (iv) Service... officials in FCIP administration, such as human resources staff, budget and finance staff, career counselors... determining financial need. An agency wishing to use the Department of Health and Human Services'...

  16. External hazards in PSA program for VVER 440/213

    International Nuclear Information System (INIS)

    The basic PSA study for the Dukovany NPP was completed in 1995. Since then a Living PSA program has come into force. All the PSA related activities are undertaken under the umbrella called Living PSA. They include support of risk management, data collection and information transfer, maintenance and improvement of PSA models. To support regulatory decision making the full scope PSA is under development. External hazards identified are: earthquake initiators, aircraft crushes and extreme rainfalls. Seismic PSA is not scheduled for near future, but team is being build up and a test example of seismic event impact is being modelled for trial evaluation

  17. 14 CFR 67.213 - General medical condition.

    Science.gov (United States)

    2010-01-01

    ... established medical history or clinical diagnosis of diabetes mellitus that requires insulin or any other... that the Federal Air Surgeon, based on the case history and appropriate, qualified medical judgment... the Federal Air Surgeon, based on the case history and appropriate, qualified medical...

  18. 2-(1,3-Benzothiazol-2-yliminomethyl-2-naphthol

    Directory of Open Access Journals (Sweden)

    Khadija O. Badahdaha

    2009-04-01

    Full Text Available In the title molecule, C18H12N2OS, the dihedral angle between the two fused-ring systems is 7.2 (1°. The hydroxy group forms an intramolecular hydrogen bond with the imino group.

  19. 27 CFR 40.213 - Tobacco products labeled for export.

    Science.gov (United States)

    2010-04-01

    ... of the product. For the purposes of this section, “repackaging” shall mean the removal of the tobacco product from its original package bearing the export marks and placement of the product in a new...

  20. 24 CFR 213.260 - Allowable methods of premium payment.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Allowable methods of premium... Allowable methods of premium payment. Premiums shall be payable in cash or in debentures at par plus accrued interest. All premiums are payable in advance and no refund can be made of any portion thereof except...

  1. Determination of D-serine in human serum by LC-MS/MS using a triazole-bonded column after pre-column derivatization with (S)-4-(3-isothiocyanatopyrrolidin-1-yl)-7- (N, N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole.

    Science.gov (United States)

    Sakamoto, Tatsuya; Kuwabara, Ryousuke; Takahashi, Shuhei; Onozato, Mayu; Ichiba, Hideaki; Iizuka, Hideaki; Fukushima, Takeshi

    2016-01-01

    An LC-MS/MS-based method for determining D-serine (Ser), an endogenous co-agonist of the N-methyl-D-aspartate receptor, in human serum, was developed and validated using a triazole-bonded silica-packed column after pre-column fluorescence derivatization with a chiral labeling reagent, (S)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole. Enantiomeric separation of the D- and L-Ser derivatives occurred in the triazole-bonded column (R s: 1.85) with CH3CN/100 mM HCO2NH4 in H2O (95.5:4.5) as the mobile phase with isocratic elution. The ln(capacity factor of D-Ser) in the van't Hoff plot gradually decreased with the inverse of temperature, suggesting enhanced hydrophilic interactions with the triazole-bonded stationary phase with increasing column temperature, owing to decrease in the partition coefficient to the mobile phase. Multiple reaction monitoring (m/z 457.10 > 409.00) by triple quadrupole mass spectrometry was used for quantifying D-Ser in human serum. The presence of D-Ser in the serum was confirmed by treatment with commercial D-amino acid oxidase. A linear calibration curve was constructed in the D-Ser concentration range of 0.5-5.0 μM (r (2) = 0.999, n = 3) using D-homoserine as the internal standard. The precision and recovery values were adequate for quantification. The detection limit for D-Ser was 1.1 fmol/injection (signal-to-noise ratio = 3), owing to the high CH3CN content in the mobile phase. The proposed LC-MS/MS method showed few fluctuations in the retention times of D- and L-Ser, and R s was stable until the 40th injection of serum without column washing, and thus can be useful for D-Ser determination in human serum in clinical research.

  2. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    International Nuclear Information System (INIS)

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  3. TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

    Energy Technology Data Exchange (ETDEWEB)

    Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

    2004-10-06

    As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

  4. Quantitative analysis of microstructure deformation in creep fenomena of ferritic SA-213 T22 and austenitic SA-213 TP304H material

    Science.gov (United States)

    Mulyana, Cukup; Taufik, Ahmad; Gunawan, Agus Yodi; Siregar, Rustam Efendi

    2013-09-01

    The failure of critical component of fossil fired power plant that operated in creep range (high stress, high temperature and in the long term) depends on its microstructure characteristics. Ferritic low carbon steel (2.25Cr-1Mo) and Austenitic stainless alloy (18Cr-8Ni) are used as a boiler tube in the secondary superheater outlet header to deliver steam before entering the turbin. The tube failure is occurred in a form of rupture, resulting trip that disrupts the continuity of the electrical generation. The research in quantification of the microstructure deformation has been done in predicting the remaining life of the tube through interrupted accelerated creep test. For Austenitic Stainless Alloy (18Cr-8Ni), creep test was done in 550°C with the stress 424.5 MPa and for Ferritic Low Carbon Steel (2.25Cr-1Mo) in 570°C with the stress 189 MPa. The interrupted accelerated creep test was done by stopping the observation in condition 60%, 70%, 80% and 90% of remaining life, the creep test fracture was done before. Then the micro hardness test, photo micro, SEM and EDS were obtained from those samples. Refer to ASTM E122, microstructure parameters were calculated. The results indicated that there are a consistency of decreasing their grain diameters, increasing their grain size numbers, micro hardness, and the length of crack or void number per unit area with the decreasing of remaining life. While morphology of grain (stated in parameter α=LV/LH) relatively constant for austenitic. However, for ferritic the change of morphology revealed significantly. Fracture mode propagation of ferritic material is growth with voids transgranular and intergranular crack, and for austenitic material the fracture growth with intergranular creep fracture void and wedge crack. In this research, it was proposed a formulation of mathematical model for creep behavior corresponding their curve fitting resulted for the primary, secondary and tertiary in accelerated creep test. In addition, it was also developed a new method for predicting the remaining life using quantification of microstructure and using expansion of parameter Larson Miller from Taylor series for critical component in high temperature in industry. It was found that the proposed method was easier to be applied in field with the results more accurate then Larson Miller Method.

  5. Study on laser atomic spectroscopy

    International Nuclear Information System (INIS)

    Laser atomic spectroscopic study on actinium element has been performed in many areas of spectroscopy. The study on characteristic of atomic vapor has been proceeded for copper atom and the spatial density distribution of copper vapor is measured. This experimental data has been compared with the theoretically calculated data. In spectroscopic experiment, the first and second excited states for actinium element are identified and the most efficient ionization scheme for actinium element is identified. In addition, the corrosion problem for filament material due to the heating of the actinium element has been studied. (Author)

  6. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  7. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  8. Characterization of neutron detector combined with NE213 and CaF{sub 2}(Eu)

    Energy Technology Data Exchange (ETDEWEB)

    Takada, Masashi; Nakamura, Takashi [Tohoku Univ., Sendai (Japan). Cyclotron and Radioisotope Center; Sibata, Tokushi

    1996-07-01

    In this work, the property of the n-{gamma} discrimination and the response functions of the developed phoswich detector were measured with gamma rays from radioactive sources and neutrons from a Be+Cu target bombarded by protons from the RIKEN ring cyclotron at the Institute of Physical and Chemical Research. The measured response functions were compared with Monte Carlo calculations. We also tested to measure a small amount of neutrons under the intense charged-particles mixed field which was realized in the RIKEN ring cyclotron for the space application. (J.P.N.)

  9. 49 CFR 213.307 - Class of track: operating speed limits.

    Science.gov (United States)

    2010-10-01

    ... hazardous material, as defined at 49 CFR 171.8, except as provided in Column 9A of the Hazardous Materials Table (49 CFR 172.101) for movement in the same train as a passenger-carrying vehicle or in Column 9B of... 49 Transportation 4 2010-10-01 2010-10-01 false Class of track: operating speed limits....

  10. Genotype-phenotype correlation in 13q13.3-q21.3 deletion.

    Science.gov (United States)

    Tosca, Lucie; Brisset, Sophie; Petit, François M; Metay, Corinne; Latour, Stéphanie; Lautier, Benoît; Lebas, Axel; Druart, Luc; Picone, Olivier; Mas, Anne-Elisabeth; Prévot, Sophie; Tardieu, Marc; Goossens, Michel; Tachdjian, Gérard

    2011-01-01

    Pure interstitial deletions of the long arm of chromosome 13 are correlated with variable phenotypes according to the size and the location of the deleted region. Deletions involving the 13q13q21 region are rare. In order to establish interstitial 13q genotype-phenotype correlation, we used high resolution 244K oligonucleotide array in addition to conventional karyotype and molecular (fluorescent in situ hybridization, microsatellite markers analysis) techniques in two independent probands carrying a deletion 13q13 to 13q21. First patient was a 3-year-old girl with mental retardation and dysmorphy carrying a 13q13.3q21.31 de novo deletion diagnosed post-natally. The second one was a fetus with de novo del(13)(q14q21.2) associated with first trimester increased nuchal translucency. We showed that specific dysmorphic features (macrocephaly, high forehead, hypertelorism, large nose, large and malformed ears and retrognathia) were correlated to the common 13q14q21 chromosomal segment. Physical examination revealed overgrowth with global measurement up to the 95th percentile in both probands. This is the second description of overgrowth in patients carrying a 13q deletion. Haploinsufficiency of common candidates genes such as CKAP2, SUGT1, LECT1, DCLK1 and SMAD9, involved in cell division and bone development, is a possible mechanism that could explain overgrowth in both patients. This study underlines also that cytogenetic analysis could be performed in patients with overgrowth.

  11. {2-[(1,3-Benzothiazol-2-ylmethoxy]-5-fluorophenyl}(4-chlorophenylmethanone

    Directory of Open Access Journals (Sweden)

    K. N. Venugopala

    2013-07-01

    Full Text Available The asymmetric unit of the title compound, C21H13ClFNO2S, contains two independent molecules with similar conformations. In the molecules, the thiazole ring is essentially planar [maximum atomic deviations = 0.014 (4 and 0.023 (5 Å] and is oriented with respect to the fluorophenyl ring and chlorophenyl rings at 9.96 (18 and 70.39 (18° in one molecule and at 7.50 (18 and 68.43 (18° in the other; the dihedral angles between the fluorophenyl and chlorophenyl rings are 64.9 (2 and 64.6 (2°, respectively. Intermolecular C—H...O and C—H...F hydrogen bonds stabilize the three-dimensional supramolecular architecture. Weak C—H...π and π–π interactions [centroid–centroid distance = 3.877 (3 Å] lead to a criss-cross molecular packing along the c axis.

  12. Calibration of ground-based lidar instrument WLS7-213

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Courtney, Michael

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertaint......This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement...... uncertainties provided by measurement standard and corresponding lidar wind speed indications with associated measurement uncertainties. The lidar calibration concerns the 10 minute mean wind speed measurements. The comparison of the lidar measurements of the wind direction with that from wind vanes...

  13. An Experimental Study of Thermal Fatigue on ASTM A 213 Grade T-23 Steel Tube

    OpenAIRE

    Jinu, G. R.; P.Sathiya; Ravichandran, G; Rathinam, A.

    2009-01-01

    Super heater tubes are subjected to alternate heating and cooling in power plants causes crack and eventually fail. This phenomenon is termed as thermal fatigue. In this paper, a laboratory simulation for reproducing thermal fatigue phenomenon is developed to determine the number of cycles of failure occurs in super heater tubes. Thermal fatigue tests are conducted in Non-Destructive Tested T23 base and SMAW welded tubes separately. The tubes are subjected to thermal cycles from 800∘C (accele...

  14. Comparison of thermal fatigue behaviour of ASTM A 213 grade T-92 base and weld tubes

    International Nuclear Information System (INIS)

    Super-heater tubes are subjected to alternate heating and cooling in power plants causing them to crack and eventually fail. This phenomenon is referred to as 'thermal fatigue.' In this paper, a laboratory simulation for reproducing the thermal fatigue phenomenon is developed to determine the number of cycles necessary before failure occurs in super-heater tubes. The temperature and strain distributions along the specimen were computed theoretically using ANSYS software for the applied temperature condition. The thermal fatigue test was conducted for both base and shielded metal arc (SMA) welded tubes separately and both passed in the non-destructive tests. These tubes were subjected to thermal cycles from 800 .deg. C (accelerated temperature) to room temperature. Oxy-acetylene heating setup was utilized as a heating source, and a water bath was utilized for quenching purposes. The tests were carried out until open cracks were identified. Surface cracks were identified in the base and weld tubes after 90 and 60 cycles respectively. This study reveals that heating and cooling cause thermal fatigue, initiate cracks in the tubes

  15. 9 CFR 93.213 - Appearance of disease among poultry in quarantine.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Appearance of disease among poultry in..., DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY...

  16. CALiPER Report 21.3: Cost-Effectiveness of Linear (T8) LED Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Naomi J.; Perrin, Tess E.; Royer, Michael P.

    2014-05-27

    Meeting performance expectations is important for driving adoption of linear LED lamps, but cost-effectiveness may be an overriding factor in many cases. Linear LED lamps cost more initially than fluorescent lamps, but energy and maintenance savings may mean that the life-cycle cost is lower. This report details a series of life-cycle cost simulations that compared a two-lamp troffer using LED lamps (38 W total power draw) or fluorescent lamps (51 W total power draw) over a 10-year study period. Variables included LED system cost ($40, $80, or $120), annual operating hours (2,000 hours or 4,000 hours), LED installation time (15 minutes or 30 minutes), and melded electricity rate ($0.06/kWh, $0.12/kWh, $0.18/kWh, or $0.24/kWh). A full factorial of simulations allows users to interpolate between these values to aid in making rough estimates of economic feasibility for their own projects. In general, while their initial cost premium remains high, linear LED lamps are more likely to be cost-effective when electric utility rates are higher than average and hours of operation are long, and if their installation time is shorter.

  17. CALiPER Report 21.3. Cost Effectiveness of Linear (T8) LED Lamps

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-05-01

    Meeting performance expectations is important for driving adoption of linear LED lamps, but cost-effectiveness may be an overriding factor in many cases. Linear LED lamps cost more initially than fluorescent lamps, but energy and maintenance savings may mean that the life-cycle cost is lower. This report details a series of life-cycle cost simulations that compared a two-lamp troffer using LED lamps (38 W total power draw) or fluorescent lamps (51 W total power draw) over a 10-year study period. Variables included LED system cost ($40, $80, or $120), annual operating hours (2,000 hours or 4,000 hours), LED installation time (15 minutes or 30 minutes), and melded electricity rate ($0.06/kWh, $0.12/kWh, $0.18/kWh, or $0.24/kWh). A full factorial of simulations allows users to interpolate between these values to aid in making rough estimates of economic feasibility for their own projects. In general, while their initial cost premium remains high, linear LED lamps are more likely to be cost-effective when electric utility rates are higher than average and hours of operation are long, and if their installation time is shorter.

  18. 24 CFR 213.277 - Right and liability under the Cooperative Management Housing Insurance Fund.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Right and liability under the...-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES COOPERATIVE HOUSING MORTGAGE INSURANCE...

  19. 48 CFR 1852.213-70 - Offeror Representations and Certifications-Other Than Commercial Items.

    Science.gov (United States)

    2010-10-01

    ... (persons with origins from Burma, Thailand, Malaysia, Indonesia, Singapore, Brunei, Japan, China, Taiwan... entitled “Buy American Act-Supplies.” (2) Foreign End Products: Line Item No. and Country of Origin (3) The...—Israeli Trade Act: NAFTA Country or Israeli End Products: Line Item No. and Country of Origin (iii)...

  20. SU-C-213-06: Dosimetric Verification of 3D Printed Electron Bolus

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, K; Corbett, M; Pelletier, C; Huang, Z; Feng, Y; Jung, J [East Carolina Univ, Greenville, NC (United States)

    2015-06-15

    Purpose: To determine the dosimetric effect of 3D printed bolus in an anthropomorphic phantom. Methods: Conformable bolus material was generated for an anthropomorphic phantom from a DICOM volume. The bolus generated was a uniform expansion of 5mm applied to the nose region of the phantom, as this is a difficult area to uniformly apply bolus clinically. A Printrbot metal 3D Printer using PLA plastic generated the bolus. A 9MeV anterior beam with a 5cm cone was used to deliver dose to the nose of the phantom. TLD measurements were compared to predicted values at the phantom surface. Film planes were analyzed for the printed bolus, a standard 5mm bolus sheet placed on the phantom, and the phantom with no bolus applied to determine depth and dose distributions. Results: TLDs measured within 2.5% of predicted value for the 3D bolus. Film demonstrated a more uniform dose distribution in the nostril region for the 3d printed bolus than the standard bolus. This difference is caused by the air gap created around the nostrils by the standard bolus, creating a secondary build-up region. Both demonstrated a 50% central axis dose shift of 5mm relative to the no bolus film. HU for the bolus calculated the PLA electron density to be ∼1.1g/cc. Physical density was measured to be 1.3g/cc overall. Conclusion: 3D printed PLA bolus demonstrates improved dosimetric performance to standard bolus for electron beams with complex phantom geometry.

  1. 2-[1-(3-Amino­phenyl­imino)­eth­yl]phenol

    OpenAIRE

    Blagus, Anita; Kaitner, Branko

    2011-01-01

    The title compound, C14H14N2O, exists as the enol–imine tautomer. A strong intra­molecular hydrogen bond between O and N atoms forms a six-membered ring with an S(6) graph-set motif, which is approximately coplanar with the phenol ring, the inter­planar angle being 3.4 (3)°. In the crystal, inter­molecular C—H⋯O hydrogen bonds and N—H⋯π inter­actions link the mol­ecules into infinite chains along [100].

  2. SU-B-213-05: Development of ABR Certification Standards

    International Nuclear Information System (INIS)

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP

  3. Analysis of a buried pipeline at WWER-440/213 Paks NPP

    International Nuclear Information System (INIS)

    According to regulations, all safety structures of a NPP must be designed to withstand loads induced by earthquakes. This applies to safety related underground piping systems. These structures are typically embedded in about 2-3 m of layered soil, and sometimes protected by concrete slabs resting on the ground surface. A rigorous solution for the dynamic response of such a structure would require accounting for nonlinear and three dimensional effects. A non-linear analysis is possible by using specialized computer codes and material models to account for non-linear behaviour of the soil. The aim of this paper was to reanalyze the pipeline of Paks NPP in order to demonstrate its dynamic behaviour interacting with the soil and the connected buildings as well as to determine the dynamic responses and the stresses in typical regions of the pipeline. To perform the numerical analysis a three dimensional finite element code (SSASSI/S) based on 'flexible volume method' was applied

  4. 77 FR 213 - United States Savings Bonds, Series EE and I

    Science.gov (United States)

    2012-01-04

    ... savings bonds, effective January 1, 2012. (See 76 FR 66,855 (Oct. 28, 2011)). In order to allow investors... Parts 351, 359, and 363 United States Savings Bonds, Series EE and I AGENCY: Bureau of the Public Debt... Series EE and Series I savings bonds a person may acquire each year. DATES: Effective January 4,...

  5. Crystal structure of 2-(1,3-dioxoindan-2-ylisoquinoline-1,3,4-trione

    Directory of Open Access Journals (Sweden)

    Raza Murad Ghalib

    2015-01-01

    Full Text Available In the title isoquinoline-1,3,4-trione derivative, C18H9NO5, the five-membered ring of the indane fragment adopts an envelope conformation with the nitrogen-substituted C atom being the flap. The planes of the indane benzene ring and the isoquinoline-1,3,4-trione ring make a dihedral angle of 82.06 (6°. In the crystal, molecules are linked into chains extending along the bc plane via C—H...O hydrogen-bonding interactions, enclosing R22(8 and R22(10 loops. The chains are further connected by π–π stacking interations, with centroid-to-centroid distances of 3.9050 (7 Å, forming layers parallel to the b axis.

  6. 49 CFR 212.213 - Motive power and equipment (MP&E) inspector.

    Science.gov (United States)

    2010-10-01

    ...), Safety Glazing Standards (49 CFR part 223), Locomotive Safety Standards (49 CFR part 229), Safety Appliance Standards (49 CFR part 231), and Power Brake Standards (49 CFR part 232), to make reports of those... Standards, Locomotive Safety Standards, Safety Appliance Standards and Power Brake Standards. (3)...

  7. 49 CFR 213.119 - Continuous welded rail (CWR); plan contents.

    Science.gov (United States)

    2010-10-01

    ... following items: (i) Loose, bent, or missing joint bolts; (ii) Rail end batter or mismatch that contributes... amount and length of rail end batter or ramp on each rail end; the amount of tread mismatch; the...

  8. Pre-perihelion observations of Comet Halley at 2-13 microns

    Science.gov (United States)

    Lynch, David K.; Russell, Ray W.; Retig, David A.; Rice, Carl J.; Young, Robert M.

    1986-01-01

    Between Nov. 8, 1985 and Jan. 13, 1986 comet Halley brightness was obtained as a function of time at 2.3, 3.6, 4.6, and 10.3 microns. Brightness outbursts were noted, an especially significant one beginning Jan. 10, 1986 and persisting for several days during which the IR brightness more than doubled. The heliocentric brightness indices for 2.3, 3.6, 4.6, and 10.3 microns are -5.7, -7.1, -8.5, and -6.2, respectively. Comet Halley's absolute magnitudes at these wavelengths are 7.3, 4.4, 2.8, and -1.8. The 4.6 to 10.3 micron color temperature dependence on heliocentric distance (R) is slightly less steep than the Rsup -1/2 expected theoretically. The albedo of the comet is 8% to 9%. Based on spectral differences between outbursts on Nov. 8, 1985 and Jan. 10 to 13, 1986, it is concluded that the comet displays composition inhomogeneities.

  9. WO21.3 Direct Drive Reentrant Cone Targets for Fast Ignition

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, R B; Nikroo, A; Hill, D; Smith, J N Jr.; Hatchett, S P; Stoeckl, C; Bonino, M J; Sangster, T C; Shiraga, H; Fujioka, S; Tanaka, K A

    2003-08-23

    Targets designed for fast ignition must have clear access for the ignitor laser to the compressed core. This is provided in current concepts by embedding a reentrant cone in the shell, the tip of the cone close to the center of the shell. We have designed a gas-tight direct-drive FI target as the first step in developing a FI ignition target, and have studied its implosion dynamics at Omega with back-lit and self-emission framing cameras. A step in the cone surface, and Al on the shell was required to make the assembly gas-tight; these assemblies withstood >10 atm and had a typical pressure half-life of 2-6 hrs. The implosion of these targets was substantially different from that of previous indirect drive targets; there was much less vaporization of the Au cone, much clearer structure in the collapsing shells, and a possibility that the hot core could escape around the cone rather than punch in its tip. Additionally self-emission images show the heating of the core gas, and its effect on the cone tip. These results will be compared to simulations.

  10. Yeast Interacting Proteins Database: YGL213C, YBR059C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ription Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin...Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; invol...ved in endocytosis and actin cytoskeleton organization Rows with this prey as prey (3) Rows with this prey a

  11. SU-B-213-06: Development of ABR Examination Questions

    International Nuclear Information System (INIS)

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP

  12. 48 CFR 213.270 - Use of the Governmentwide commercial purchase card.

    Science.gov (United States)

    2010-10-01

    ... exception for an electronic commerce/electronic data interchange system or operational requirement that... Medical Electronic Catalog Program are two examples where use of the purchase card may not be...

  13. 5 CFR 532.213 - Industries included in regular appropriated fund wage surveys.

    Science.gov (United States)

    2010-01-01

    ... transportation except taxi and limousine service (NAICS 4853). 487 (except 4872) Scenic and sightseeing transportation except scenic and sightseeing transportation, water (NAICS 4872). 488 (except 4883 and 4884... support activities for road transportation (NAICS 4884). 492 Couriers and messengers. 493 Warehousing...

  14. 49 CFR 40.213 - What training requirements must STTs and BATs meet?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What training requirements must STTs and BATs meet... requirements must STTs and BATs meet? To be permitted to act as a BAT or STT in the DOT alcohol testing program...). (1) Qualification training must be in accordance with the DOT Model BAT or STT Course, as...

  15. 8 CFR 213a.4 - Actions for reimbursement, public notice, and congressional reports.

    Science.gov (United States)

    2010-01-01

    ..., or joint sponsor, by personal service, as defined by 8 CFR 103.5a(a)(2), except that the person... obtain the sponsored immigrant's current immigration or citizenship status or the name, social security... immigrant wants to seek reimbursement from a sponsor, household member, or joint sponsor, the...

  16. SU-C-213-03: Custom 3D Printed Boluses for Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, B; Yang, M; Yan, Y; Rahimi, A; Chopra, R; Jiang, S [UT Southwestern Medical Center, Dallas, TX (United States)

    2015-06-15

    Purpose: To develop a clinical workflow and to commission the process of creating custom 3d printed boluses for radiation therapy. Methods: We designed a workflow to create custom boluses using a commercial 3D printer. Contours of several patients were deformably mapped to phantoms where the test bolus contours were designed. Treatment plans were created on the phantoms following our institutional planning guideline. The DICOM file of the bolus contours were then converted to stereoLithography (stl) file for the 3d printer. The boluses were printed on a commercial 3D printer using polylactic acid (PLA) material. Custom printing parameters were optimized in order to meet the requirement of bolus composition. The workflow was tested on multiple anatomical sites such as skull, nose and chest wall. The size of boluses varies from 6×9cm2 to 12×25cm2. To commission the process, basic CT and dose properties of the printing materials were measured in photon and electron beams and compared against water and soft superflab bolus. Phantoms were then scanned to confirm the placement of custom boluses. Finally dose distributions with rescanned CTs were compared with those computer-generated boluses. Results: The relative electron density(1.08±0.006) of the printed boluses resemble those of liquid tap water(1.04±0.004). The dosimetric properties resemble those of liquid tap water(1.04±0.004). The dosimetric properties were measured at dmax with an ion chamber in electron and photon open beams. Compared with solid water and soft bolus, the output difference was within 1% for the 3D printer material. The printed boluses fit well to the phantom surfaces on CT scans. The dose distribution and DVH based on the printed boluses match well with those based on TPS generated boluses. Conclusion: 3d printing provides a cost effective and convenient solution for patient-specific boluses in radiation therapy.

  17. SU-C-213-03: Custom 3D Printed Boluses for Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: To develop a clinical workflow and to commission the process of creating custom 3d printed boluses for radiation therapy. Methods: We designed a workflow to create custom boluses using a commercial 3D printer. Contours of several patients were deformably mapped to phantoms where the test bolus contours were designed. Treatment plans were created on the phantoms following our institutional planning guideline. The DICOM file of the bolus contours were then converted to stereoLithography (stl) file for the 3d printer. The boluses were printed on a commercial 3D printer using polylactic acid (PLA) material. Custom printing parameters were optimized in order to meet the requirement of bolus composition. The workflow was tested on multiple anatomical sites such as skull, nose and chest wall. The size of boluses varies from 6×9cm2 to 12×25cm2. To commission the process, basic CT and dose properties of the printing materials were measured in photon and electron beams and compared against water and soft superflab bolus. Phantoms were then scanned to confirm the placement of custom boluses. Finally dose distributions with rescanned CTs were compared with those computer-generated boluses. Results: The relative electron density(1.08±0.006) of the printed boluses resemble those of liquid tap water(1.04±0.004). The dosimetric properties resemble those of liquid tap water(1.04±0.004). The dosimetric properties were measured at dmax with an ion chamber in electron and photon open beams. Compared with solid water and soft bolus, the output difference was within 1% for the 3D printer material. The printed boluses fit well to the phantom surfaces on CT scans. The dose distribution and DVH based on the printed boluses match well with those based on TPS generated boluses. Conclusion: 3d printing provides a cost effective and convenient solution for patient-specific boluses in radiation therapy

  18. High energy phenomena around collapsed stars; Proceedings of the NATO Advanced Study Institute, Cargese, France, Sept. 2-13, 1985

    Science.gov (United States)

    Pacini, F.

    Recent studies of high-energy phenomena around collapsed stars are reported. The topics considered include: stellar evolution and the formation of binary systems, observations of supernovae, the dynamics of supernova envelopes, stellar collapse and supernova explosions, comparison of white dwarfs and neutron stars, observations of pulsars, energetic radiation from magnetized neutron stars, neutron stars as cosmic hadron physical laboratories, recent developments on the Crab Nebula, and the association between supernova remnants and pulsars. Also addressed are: progenitors and products of supernovae, plerions in theory and practice, binary origin of pulsar velocities, black holes and gamma-ray sources in the Galaxy, cosmic gamma ray bursts, propagation and origin of Galactic cosmic rays, information on the boundary layer of quasi-periodic oscillations in the Galactic bulge sources using power spectra, and the 35-day cycle of Her X-1.

  19. Poly[tetrakis[μ2-1,3-bis(4-pyridylpropane-κ2N:N′]dichloridobis(phenylacetatodimanganese(II

    Directory of Open Access Journals (Sweden)

    Wei Xu

    2010-03-01

    Full Text Available In the title compound, [Mn2(C8H7O22Cl2(C13H14N24]n, the two MnII atoms lie on inversion centers and are connected by the N-heterocyclic ligands into a wave-like lamellar framework structure. One MnII atom is covalently bonded to two Cl atoms and the other to two benzylacetate anions; both Mn atoms show distorted octahedral coordinations.

  20. Integrated safety assessment report, Haddam Neck Plant (Docket No. 50-213): Integrated Safety Assessment Program: Draft report

    International Nuclear Information System (INIS)

    The operating history of the plant from 1967 through 1984 was reviewed and analyzed. The findings of the review identified trends and symptoms in the operating data that can be used as tools in the resolution and prioritization of the Haddam Neck safety issues. The review included evaluation of data collected on plant availability and capacity factors, forced shutdowns, power reductions, reportable events, and environmental considerations. The methodology used is also discussed. Data and information is presented in appendices. Haddam Neck Plant has generally been operated in a safe and orderly manner, with a trend that shows continuous improvement. Perturbations to this trend were correlated to an extensive turbine refit, post-effects of an extended operating run, and effects of efforts applied in response to TMI. Three specific symptoms of continuing safety related problems were recurrence of loss of offsite power events, control rod drive failures, and charging pump failures. 24 refs., 21 figs., 11 tabs

  1. [Nebraska 4-H Wheat Science School Enrichment Project, Teacher/Leader Guides 213-222 and 227.

    Science.gov (United States)

    Nebraska Univ., Lincoln. Inst. of Agriculture and Natural Resources.

    Through the 4-H Wheat Science project, students learn the importance of wheat from the complete process of growing wheat to the final product of bread. The curriculum is designed to include hands-on experiences in science, consumer education, nutrition, production economics, vocabulary, and applied mathematics. Teachers can select those units out…

  2. SU-D-213-02: Characterization of the Effect of a New Commercial Transmission Detector On Radiotherapy Beams

    International Nuclear Information System (INIS)

    Purpose: To evaluate the influence of a new commercial transmission detector on radiotherapy beams of various energies. Methods: A transmission detector designed for online treatment monitoring was characterized on a TrueBeam STx linear accelerator with 6MV, 6FFF, 10MV, and 10FFF beams. Measurements of beam characteristics including percentage depth doses (PDDs), inplane and crossplane off-axis profiles at different depths, transmission factors, and skin dose were acquired at field sizes of 3×3cm, 5×5m, 10×10cm, and 20×20cm at 100cm and 80cm source-to-surface distance (SSD). All measurements were taken with and without the transmission detector in the path of the beam. A CC04 chamber was used for all profile and transmission factor measurements. Skin dose was assessed at 100cm, 90cm, and 80cm SSD and using a variety of detectors (Roos and Markus parallel-plate chambers, and OSLD). Results: The PDDs showed small differences between the unperturbed and perturbed beams for both 100cm and 80cm SSD (≤4mm dmax difference and <1.2% average profile difference). The differences were larger for the flattened beams and at larger field sizes. The off-axis profiles showed similar trends. The penumbras looked similar with and without the transmission detector. Comparisons in the central 80% of the profile showed a maximum average (maximum) profile difference between all field sizes of 0.756% (1.535%) and 0.739% (3.682%) for 100cm and 80cm SSD, respectively. The average measured skin dose at 100cm (80cm) SSD for 10×10cm field size was <4% (<35%) dose increase for all energies. For 20×20cm field size, this value increased to <10% (≤45%). Conclusion: The transmission detector has minimal effect on the clinically relevant radiotherapy beams for IMRT and VMAT (field sizes 10×10cm and less). For larger field sizes, some perturbations are observable which would need to be assessed for clinical impact. The authors of this publication has research support from IBA Dosimetry

  3. 2-(1,3-Dioxoisoindolin-2-ylacetic acid–N′-[(E-2-methoxybenzylidene]pyridine-4-carbohydrazide (1/1

    Directory of Open Access Journals (Sweden)

    Shaaban K. Mohamed

    2012-08-01

    Full Text Available In the title 1:1 cocrystal, C10H7NO4·C14H13N3O2, molecules are linked by intermolecular C—H...O, N—H...O and O—H...N hydrogen bonds, forming a three-dimensional network. In addition, π–π stacking interactions [with centroid–centroid distances of 3.5723 (19 and 3.6158 (18 Å] are observed.

  4. SU-C-213-02: Characterizing 3D Printing in the Fabrication of Variable Density Phantoms

    International Nuclear Information System (INIS)

    Purpose: In this work, we present characterization, process flow, quality control and application of 3D fabricated low density phantoms for radiotherapy quality assurance. Methods: A Rostock delta 3D printer using polystyrene filament of diameter 1.75 mm was used to print geometric volumes of 2×2×1 cm3 of varying densities. The variable densities of 0.1 to 0.75 g/cm 3 were created by modulating the infill. A computed tomography (CT) scan was performed to establish an infill-density calibration curve as well as characterize the quality of the print such as uniformity and the infill pattern. The time required to print these volumes was also recorded. Using the calibration, two low density cones (0.19, 0.52 g/cm3) were printed and benchmarked against commercially available phantoms. The dosimetric validation of the low density scaling of Anisotropic Analytical Algorithm (AAA) was performed by using a 0.5 g/cm3 slab of 10×10×2.4 cm3 with EBT3 GafChromic film. The gamma analysis at 3%/3mm criteria were compared for the measured and computed dose planes. Results: Analysis of the volume of air pockets in the infill resulted in a reasonable uniformity for densities 0.4 to 0.75 g/cm3. Printed phantoms with densities below 0.4 g/cm3 exhibited a higher ratio of air to polystyrene resulting in large non-uniformity. Compared to the commercial inserts, good agreement was observed only for the printed 0.52 g/cm3 cone. Dosimetric comparison for a printed low density volume placed in-between layers of solid water resulted in >95% gamma agreement between AAA calculated dose planes and measured EBT3 films for a 6MV 5×5 cm2 clinical beam. The comparison showed disagreement in the penumbra region. Conclusion: In conclusion, 3D printing technology opens the door to desktop fabrication of variable density phantoms at economical prices in an efficient manner for the quality assurance needs of a small clinic

  5. Orthorectification and Mosaicking of Color Aerial Photography for the Main Eight Hawaiian Islands: Oahu (213-214e-0516)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Habitat maps of the main Hawaiian Islands were created by visual interpretation of aerial photos and hyperspectral imagery using the Habitat Digitizer extension....

  6. Integrated plant safety assessment: systematic evaluation program. Haddam Neck Plant, Connecticut Yankee Atomic Power Company. Docket No. 50-213

    International Nuclear Information System (INIS)

    The Systematic Evaluation Program was initiated in February 1977 by the US Nuclear Regulatory Commission to review the designs of older operating nuclear reactor plants to confirm and document their safety. The review provides: (1) an assessment of how these plants compare with current licensing safety requirements relating to selected issues, (2) a basis for deciding on how these differences should be resolved in an integrated plant review, and (3) a documented evaluation of plant safety. This report documents the review of Haddam Neck Plant, operated by Connecticut Yankee Atomic Power Company. The Haddam Neck Plant is one of 10 plants reviewed under Phase II of this program. This report indicates how 137 topics selected for review under Phase I of the program were addressed. Equipment and procedural changes have been identified as a result of the review

  7. 49 CFR 1546.213 - Access to cargo: Security threat assessments for cargo personnel in the United States.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Access to cargo: Security threat assessments for...: Security threat assessments for cargo personnel in the United States. This section applies in the United...— (1) Each individual must successfully complete a security threat assessment or comparable...

  8. Severe accident management development program for VVER-1000 and VVER-440/213 based on the westinghouse owners group approach

    International Nuclear Information System (INIS)

    The development of the Westinghouse Owners Group Severe Accident Management Guidelines (WOG SAMG) between 1991 and 1994 was initiated in response to the U.S. Nuclear Regulatory Commission (NRC) requirement for addressing the regulatory severe accident concerns. Hence, the WOG SAMG is designed to interface with other existing procedures at the plant and is used in accident sequences that have progressed to the point where these other procedures are not applicable any longer, i.e. following core damage. The primary purpose of the WOG SAMG is to reach a controlled stable state, which can be declared when fission product releases are controlled, challenges to the confinement fission product boundary have been mitigated, and adequate heat removal is provided to the core and the containment. Although the WOG SAMG is a generic severe accident management guidance developed for use by the entirety of the operating Westinghouse PWR plants, provisions have been made in their development to address specific features of individual plants such as confinement type and the feasibility of reactor cavity flooding. Similarly, the generic SAMG does not address unique plant features and equipment, but rather allows for consideration of plant specific features and strategies. This adaptable approach has led to several SAMG development programs for VVER-1000 and VVER-440 type of power plants, under Westinghouse' s lead. The first of these programs carried out to completion was for Temelin NPP - VVER-1000 - in the first quarter of 2003. Other ongoing programs aim at providing a similar work for VVER-440 design, namely Dukovany, Mochovce and Bohunice NPPs. The challenge of adapting the existing generic WOG material to plants other than PWRs mainly arises for VVER-440 because of important differences in confinement design, making it more vulnerable to ex-vessel phenomena such as hydrogen burn. Also, for both eastern designs, cavity flooding strategy requires special consideration and adaptation on a case by case basis. The purpose of this paper is to provide some insights on how SAMG programs can be implemented for VVER-1000 and VVER-440 type of plants based on the WOG SAMG generic approach, and identifies areas of technical concerns encountered in the process. Solutions are proposed based on the experience of past and ongoing programs. (author)

  9. Echtzeitdetektion von Punktmutationen mit DNA-Chips am Beispiel des SULT1A1*213-SNP

    OpenAIRE

    Gajovic-Eichelmann, Nenad; Griep, Andrea; Ehrentreich-Förster, Eva; Bier, Frank F

    2001-01-01

    Der Identifizierung von Punktmutationen im menschlichen Genom kommt eine hohe Bedeutung zu. Die Entdeckung einer Vielzahl von SNPs ('single nucleotide polymorphisms'), also Mutationen einzelner Basen, die definitionsgemäß bei mehr als 1% der Bevölkerung auftreten, und die Erkenntnis, dass SNPs die Nebenwirkungen von Medikamenten determinieren können, führte zu der Vision einer 'personalisierten Medizin': Der Patient erhält nach einer Genotypisierung das für ihn verträglichste Medikament versc...

  10. Pre-operational integrated pressure tests at EMO NPP (VVER 440/V 213) and options for their experimental utilization

    International Nuclear Information System (INIS)

    Pre-operational integrated leakage rate and structural integrity tests for the Mochovce NPP are discussed. A programme is presented of experiments proposed during these tests, to be used in investigations of the following phenomena: water drop entrainment from the water pool into the air trap; hydraulic resistance and leaktightness of check valve DN 500; performance of valves DN 250; response of bubble condenser walls to loading; phenomenology of the whole process and verification of some partial analytical and experimental procedures. (Z.S.) 2 figs

  11. Dietary Iron Intake and Serum Ferritin Concentration in 213 Patients Homozygous for the HFEC282Y Hemochromatosis Mutation

    Directory of Open Access Journals (Sweden)

    Victor R Gordeuk

    2012-01-01

    Full Text Available BACKGROUND: HFEC282Y homozygotes have an increased risk for developing increased iron stores and related disorders. It is controversial whether dietary iron restrictions should be recommended to such individuals.

  12. Oahu Photomosaic 2000 (213-214e-0516) - Orthorectification and Mosaicing of Color Aerial Photography Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Habitat maps of the main Hawaiian Islands were created by visual interpretation of aerial photos and hyperspectral imagery using the Habitat Digitizer extension....

  13. 2-(1,3-Benzothia­zol-2-yl)-6-eth­oxy­phenol

    OpenAIRE

    Lakshmanan, D.; Raj, R. Madhan; Selvakumar, R; Bakthadoss, M.; Murugavel, S.

    2011-01-01

    In the title compound, C15H13NO2S, the benzothia­zole unit is essentially planar [maximum deviation = −0.0099 (5) Å for the S atom] and is oriented at a dihedral angle of 4.8 (5)° with respect to the benzene ring. An intra­molecular O—H⋯N hydrogen bond generates an S(6) ring motif. The crystal packing is stabilized by C—H⋯π inter­actions.

  14. SU-C-213-02: Characterizing 3D Printing in the Fabrication of Variable Density Phantoms

    Energy Technology Data Exchange (ETDEWEB)

    Madamesila, J; McGeachy, P; Villarreal-Barajas, J; Khan, R [The University of Calgary, Calgary, AB (Canada)

    2015-06-15

    Purpose: In this work, we present characterization, process flow, quality control and application of 3D fabricated low density phantoms for radiotherapy quality assurance. Methods: A Rostock delta 3D printer using polystyrene filament of diameter 1.75 mm was used to print geometric volumes of 2×2×1 cm{sup 3} of varying densities. The variable densities of 0.1 to 0.75 g/cm {sup 3} were created by modulating the infill. A computed tomography (CT) scan was performed to establish an infill-density calibration curve as well as characterize the quality of the print such as uniformity and the infill pattern. The time required to print these volumes was also recorded. Using the calibration, two low density cones (0.19, 0.52 g/cm{sup 3}) were printed and benchmarked against commercially available phantoms. The dosimetric validation of the low density scaling of Anisotropic Analytical Algorithm (AAA) was performed by using a 0.5 g/cm{sup 3} slab of 10×10×2.4 cm{sup 3} with EBT3 GafChromic film. The gamma analysis at 3%/3mm criteria were compared for the measured and computed dose planes. Results: Analysis of the volume of air pockets in the infill resulted in a reasonable uniformity for densities 0.4 to 0.75 g/cm{sup 3}. Printed phantoms with densities below 0.4 g/cm{sup 3} exhibited a higher ratio of air to polystyrene resulting in large non-uniformity. Compared to the commercial inserts, good agreement was observed only for the printed 0.52 g/cm{sup 3} cone. Dosimetric comparison for a printed low density volume placed in-between layers of solid water resulted in >95% gamma agreement between AAA calculated dose planes and measured EBT3 films for a 6MV 5×5 cm{sup 2} clinical beam. The comparison showed disagreement in the penumbra region. Conclusion: In conclusion, 3D printing technology opens the door to desktop fabrication of variable density phantoms at economical prices in an efficient manner for the quality assurance needs of a small clinic.

  15. 普罗帕酮转复阵发性室上性心动过速213

    Institute of Scientific and Technical Information of China (English)

    谢宏炯; 李克力

    2007-01-01

    阵发性室上性心动过速(paroxysmal suprarventricuar tachycardia,PSVT)是门诊、急诊中最常见的快速型心律失常,自2000年至2005年,笔者将舒城县人民医院门、急诊中遇到的绝大部分PSVT患,占同期该类就诊者95%,以普罗帕酮作为首选药进行复律治疗,获得良好疗效,现报道如下。

  16. Integrated safety assessment report, Haddam Neck Plant (Docket No. 50-213): Integrated Safety Assessment Program: Draft report

    International Nuclear Information System (INIS)

    The integrated assessment is conducted on a plant-specific basis to evaluate all licensing actions, licensee initiated plant improvements and selected unresolved generic/safety issues to establish implementation schedules for each item. Procedures allow for a periodic updating of the schedules to account for licensing issues that arise in the future. The Haddam Neck Plant is one of two plants being reviewed under the pilot program. This report indicates how 82 topics selected for review were addressed, and presents the staff's recommendations regarding the corrective actions to resolve the 82 topics and other actions to enhance plant safety. 135 refs., 4 figs., 5 tabs

  17. SU-D-213-07: Initial Characterization of a Gel Patch Dosimeter for in Vivo Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Matrosic, C; Culberson, W; Rosen, B; Madsen, E; Frank, G; Bednarz, B [Univ of Wisc Madison, Madison, WI (United States)

    2015-06-15

    Purpose: In vivo dosimetry, despite being the most direct method for monitoring the dose delivered during radiation therapy and being recommended by several national and international organizations (AAPM, ICRU, NACP), is underutilized in the clinic due to issues associated with dose sensitivity, feasibility, and cost. Given the increasing complexity of radiation therapy modern treatments, there is a compelling need for a robust, affordable in vivo dosimetry option. In this work we present the initial characterization of a novel gel patch in vivo dosimeter. Methods: DEFGEL (6%T) was used to make 1-cm thick small cylindrical patch dosimeters. The optical density of each dosimeter was read before and after irradiation by an in-house laser densitometer. The dosimeters were irradiated using a Varian Clinac EX linac. Three separate batches of gel patches were used to create dose response curves and evaluate repeatability. The development time of the dosimeter was also evaluated. Results: The dose response of the dosimeter was found to be linear from a range of approximately 1-Gy to 20-Gy, which is a larger window of linearity compared to other in vivo dosimeters. At doses below 1-Gy, the cumulative uncertainties were on the order of the measured data. When compared, the three batches demonstrated repeatability from 1-Gy to approximately 13-Gy, with some variation at higher doses. For doses of >8-Gy, the dosimeter reached full optical density after 4-hours, whereas low doses developed within an hour. Conclusion: Initial results indicate that the gel patch dosimeter is a reliable and simple way to measure a large range of doses, including high doses such as those delivered during hypofractionated treatments (e.g. SBRT or MR-guided radiotherapy). The simple fabrication method for the dosimeter and the use of a laser densitometer would allow for the dosimeter to used and read in-house, cheaply and easily.

  18. SU-D-213-02: Characterization of the Effect of a New Commercial Transmission Detector On Radiotherapy Beams

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, J; Morin, O [University of California San Francisco, San Francisco, CA (United States)

    2015-06-15

    Purpose: To evaluate the influence of a new commercial transmission detector on radiotherapy beams of various energies. Methods: A transmission detector designed for online treatment monitoring was characterized on a TrueBeam STx linear accelerator with 6MV, 6FFF, 10MV, and 10FFF beams. Measurements of beam characteristics including percentage depth doses (PDDs), inplane and crossplane off-axis profiles at different depths, transmission factors, and skin dose were acquired at field sizes of 3×3cm, 5×5m, 10×10cm, and 20×20cm at 100cm and 80cm source-to-surface distance (SSD). All measurements were taken with and without the transmission detector in the path of the beam. A CC04 chamber was used for all profile and transmission factor measurements. Skin dose was assessed at 100cm, 90cm, and 80cm SSD and using a variety of detectors (Roos and Markus parallel-plate chambers, and OSLD). Results: The PDDs showed small differences between the unperturbed and perturbed beams for both 100cm and 80cm SSD (≤4mm dmax difference and <1.2% average profile difference). The differences were larger for the flattened beams and at larger field sizes. The off-axis profiles showed similar trends. The penumbras looked similar with and without the transmission detector. Comparisons in the central 80% of the profile showed a maximum average (maximum) profile difference between all field sizes of 0.756% (1.535%) and 0.739% (3.682%) for 100cm and 80cm SSD, respectively. The average measured skin dose at 100cm (80cm) SSD for 10×10cm field size was <4% (<35%) dose increase for all energies. For 20×20cm field size, this value increased to <10% (≤45%). Conclusion: The transmission detector has minimal effect on the clinically relevant radiotherapy beams for IMRT and VMAT (field sizes 10×10cm and less). For larger field sizes, some perturbations are observable which would need to be assessed for clinical impact. The authors of this publication has research support from IBA Dosimetry.

  19. Chromosome 1p21.3 microdeletions comprising DPYD and MIR137 are associated with intellectual disability

    NARCIS (Netherlands)

    Willemsen, M.H.; Valles, A.; Kirkels, L.A.; Mastebroek, M.; Olde Loohuis, N.; Kos, A.; Wissink-Lindhout, W.M.; Brouwer, A.P.M. de; Nillesen, W.M.; Pfundt, R.; Holder-Espinasse, M.; Vallee, L.; Andrieux, J.; Coppens-Hofman, M.C.; Rensen, H.; Hamel, B.C.J.; Bokhoven, H. van; Aschrafi, A.; Kleefstra, T.

    2011-01-01

    Background MicroRNAs (miRNAs) are non-coding gene transcripts involved in post-transcriptional regulation of genes. Recent studies identified miRNAs as important regulators of learning and memory in model organisms. So far, no mutations in specific miRNA genes have been associated with impaired cogn

  20. catena-Poly[[diaquacalcium]bis[μ-2-(1,3-dioxoisoindolin-2-ylacetato]-κ3O,O′:O;κ3O:O,O′

    Directory of Open Access Journals (Sweden)

    Moazzam H. Bhatti

    2011-08-01

    Full Text Available In the title complex, [Ca(C10H6NO42(H2O2]n, the CaII atom lies on a twofold rotation axis and adopts a dodecahedral geometry. The CaII atom is octacoordinated by two O atoms from two water molecules and six O atoms from four acetate ligands. Each acetate acts as a tridentate ligand bridging two CaII atoms, resulting in a chain running along the c axis. O—H...O and C—H...O hydrogen bonds connect the chains into a two-dimensional network parallel to [011]. π–π interactions between adjacent isoindoline-1,3-dione rings [centroid–centroid distance = 3.4096 (11 Å] further consolidate the structure. One of the carboxylate O atoms is disordered over two sites in a 0.879 (12:0.121 (12 ratio.

  1. 20 CFR 645.213 - Who may be served as an individual in the “other eligibles” (30 percent) provision?

    Science.gov (United States)

    2010-04-01

    ... pregnancy, or having a poor work history. States, in consultation with the operating entity, may designate... section 475(4) under part E of the Social Security Act, or (c)(1) Is a custodial parent with income below..., exclusive of unemployment compensation, child support payments, and old-age and survivors benefits...

  2. In vitro screening for synergism of high-linear energy transfer Bi-213-radiotherapy with other therapeutic agents for the treatment of B-Cell chronic lymphocytic leukemia

    NARCIS (Netherlands)

    Vandenbulcke, Katia; Thierens, Hubert; De Vos, Filip; Philippe, Jan; Offner, Fritz; Janssens, Ann; Apostolidis, Christos; Morgenstern, Alfred; Bacher, Klaus; de Gelder, Virginie; Dierckx, Rudi A.; Slegers, Guido

    2006-01-01

    Background: External beam radiotherapy and beta-radioimmunotherapy (RIT) are effective treatments for lymphoid malignancies. The development of RIT with alpha-emitters is attractive, owing to the high (LET) nature and short path length of alpha particles allowing for higher tumor cell kill and lower

  3. 47 CFR 25.213 - Inter-Service coordination requirements for the 1.6/2.4 GHz mobile-satellite service.

    Science.gov (United States)

    2010-10-01

    ...) A beacon-actuated protection zone may be used in lieu of fixed protection zones in the 1610.6-1613.8... ESMU on the specifics of beacon operations. (viii) Additional radio astronomy sites, not located...

  4. Integrated Plant Safety Assessment: Systematic Evaluation Program. Haddam Neck Plant, Connecticut Yankee Atomic Power Company, Docket No. 50-213. Final report

    International Nuclear Information System (INIS)

    The Systematic Evaluation Progam was initiated in February 1977 by the US Nuclear Regulatory Commission review the designs of older operating nuclear reactor plants to confirm and document their safety. The review provides: (1) an assessment of how these plants compare with curent licensing safety requirements relating to selected issues, (2) a basis for deciding on how these differences should be resolved in an integrated plant review, and (3) a documented evaluation of plant safety. This report documents the review of Haddam Neck Plant, operated by Connecticut Yankee Atomic Power Company. The Haddam Neck Plant is one of 10 plants reviewed under Phase II of this program. This report indicates how 137 topics selected for review under Phase I of the program were addressed. Equipment and procedural changes have been identified as a result of the review

  5. NRC review of Electric Power Research Institute`s advanced light water reactor utility requirements document. Passive plant designs, chapters 2-13, project number 669

    Energy Technology Data Exchange (ETDEWEB)

    1994-08-01

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the {open_quotes}Advanced Light Water Reactor [ALWR] Utility Requirements Document{close_quotes}, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume I, {open_quotes}ALWR Policy and Summary of Top-Tier Requirements{close_quotes}, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, {open_quotes}NRC Review of Electric Power Research Institute`s Advanced Light Water Reactor Utility Requirements Document - Program Summary{close_quotes}, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff`s review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  6. SU-C-213-04: Application of Depth Sensing and 3D-Printing Technique for Total Body Irradiation (TBI) Patient Measurement and Treatment Planning

    International Nuclear Information System (INIS)

    Purpose: To develop and validate an innovative method of using depth sensing cameras and 3D printing techniques for Total Body Irradiation (TBI) treatment planning and compensator fabrication. Methods: A tablet with motion tracking cameras and integrated depth sensing was used to scan a RANDOTM phantom arranged in a TBI treatment booth to detect and store the 3D surface in a point cloud (PC) format. The accuracy of the detected surface was evaluated by comparison to extracted measurements from CT scan images. The thickness, source to surface distance and off-axis distance of the phantom at different body section was measured for TBI treatment planning. A 2D map containing a detailed compensator design was calculated to achieve uniform dose distribution throughout the phantom. The compensator was fabricated using a 3D printer, silicone molding and tungsten powder. In vivo dosimetry measurements were performed using optically stimulated luminescent detectors (OSLDs). Results: The whole scan of the anthropomorphic phantom took approximately 30 seconds. The mean error for thickness measurements at each section of phantom compare to CT was 0.44 ± 0.268 cm. These errors resulted in approximately 2% dose error calculation and 0.4 mm tungsten thickness deviation for the compensator design. The accuracy of 3D compensator printing was within 0.2 mm. In vivo measurements for an end-to-end test showed the overall dose difference was within 3%. Conclusion: Motion cameras and depth sensing techniques proved to be an accurate and efficient tool for TBI patient measurement and treatment planning. 3D printing technique improved the efficiency and accuracy of the compensator production and ensured a more accurate treatment delivery

  7. The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the natural occurring R213G substitution

    DEFF Research Database (Denmark)

    Gottfredsen, Randi Heidemann; Goldstrohm, David; Hartney, John;

    2014-01-01

    and associated with the cell surface via the extracellular matrix (ECM)-binding region. Upon cellular activation induced by lipopolysaccharide, EC-SOD is relocated and detected both in the cell culture medium and in lipid raft structures. Although the secreted material presented a significantly reduced ligand...

  8. Associated factors to the occurrence of motorcycle accident in the perception of hospitalized motorcyclist - doi:10.5020/18061230.2010.p213

    Directory of Open Access Journals (Sweden)

    Augediva Maria Jucá Pordeus

    2012-01-01

    Full Text Available Objective: To describe the social demographic characteristics of injured motorcyclists admitted into an emergency hospital and their perception about the accident. Methods: A cross-sectional study conducted between October and December 2007 with a sample of 209 patients who were victims of motorcycle accidents. A form was applied for data collection and the data were submitted to frequency analysis. The studied variables comprised social demographic data; conditions of the accident; the use of alcohol and the perception of the victim in relation to the accident. Results: Out of 209 interviewed patients, 183 (88% were male, 88 (42% were aged 21 to 30 years; 147 (65.9% were from different counties of the accident site, 89 (53.9% were not licensed riders; 93 (56.3% did not wear a helmet and 113 (54.4% reported drinking alcohol before the accident. Regarding the perception of the victims about the cause of the accident, 90 (43% highlighted the inappropriate behavior of their own rider. Conclusion: The study revealed that among injured motorcyclists, prevailed males, young and single, who did not wear helmet at the time of the accident, who were not legally qualified to drive a motorcycle and who recognize as the main cause of these accidents their own inadequate behavior

  9. NRC review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document - Evolutionary plant designs, Chapters 2--13, Project No. 669

    International Nuclear Information System (INIS)

    The staff of the US Nuclear Regulatory Commission has prepared Volume 2 (Parts 1 and 2) of a safety evaluation report (SER), ''NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document -- Evolutionary Plant Designs,'' to document the results of its review of the Electric Power Research Institute's ''Advanced Light Water Reactor Utility Requirements Document.'' This SER gives the results of the staff's review of Volume II of the Requirements Document for evolutionary plant designs, which consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant (approximately 1300 megawatts-electric)

  10. Status of ITER task T213 collaborative irradiation screening experiment on Cu/SS joints in the Russian Federation SM-2-reactor

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, D.J. [Pacific Northwest National Lab., Richland, WA (United States); Fabritsiev, S.A. [D.V. Efremov Inst., St. Petersburg (Russian Federation); Pokrovsky, A.S. [SRIAR, Dimitrovgrad (Russian Federation); Zinkle, S.J. [Oak Ridge National Lab., TN (United States)] [and others

    1996-04-01

    Specimen fabrication is underway for an irradiation screening experiment planned to start in January 1996 in the SM-2 reactor in Dimitrovgrad, Russia. The purpose of the experiment is to evaluate the effects of neutron irradiation at ITER-relevant temperatures on the bond integrity performance of Cu/SS and Be/Cu joints, as well as to further investigate the base metal properties of irradiated copper alloys. Specimens from each of the four ITER parties (U.S., EU, japan, and RF) will be irradiated to a dose of {approx}0.2 dpa at two different temperatures, 150 and 300{degrees}C. The specimens will consist of Cu/SS and Be/Cu joints in several different geometries, as well as a large number of specimens from the base materials. Fracture toughness data on base metal and Cu/SS bonded specimens will be obtained from specimens supplied by the U.S. Due to lack of material, the Be/Cu specimens supplied by the U.S will only be irradiated as TEM disks.

  11. �Return to the Lord your God, for he is gracious and compassionate...� (Jl 2:13. A prophetic perspective on reconciliation and restoration

    Directory of Open Access Journals (Sweden)

    W J Wessels

    2005-10-01

    Full Text Available In this article the Old Testament prophetic literature will be the focus of discussion with regard to the matter of restoring broken relationships, be it between God and humans or between humans as such. The relationship between Yahweh and his people was formally established by means of a covenant. The presentation of the prophetic material is done with a narrow focus on the issues of reconciliation and restoration. Prophets and prophetic� texts are selected with the mentioned focus in mind and presented as the results of research done on the chosen texts. It is therefore done with a real awareness of the complexity of the prophetic material and the historical embedding of prophetic material. A detailed discussion of introductory and theological issues are therefore not presented, but taken into account. What result in this paper is a focussed presentation on the mentioned topics in some of the prophetic material. Although the word reconciliation is not an Old Testament concept, it is clear that the idea of re-establishment and renewal of� the relationship between God and people was ever present. The prophets had the duty to address the reasons for damage to this covenant relationship and to warn the people of the consequences if they continue to disobey the stipulations and ethical demands of this relationship. The prophets not only served as witnesses of the efforts of Yahweh to reconcile with his people, but also as instruments to bring it about.�

  12. SU-B-213-00: Education Council Symposium: Accreditation and Certification: Establishing Educational Standards and Evaluating Candidates Based on these Standards

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP.

  13. (E-4-[7-(2,3-Dihydrothieno[3,4-b][1,4]dioxin-5-yl-2,1,3-benzothiadiazol-4-yl]-2-[(neopentyliminomethyl]phenol

    Directory of Open Access Journals (Sweden)

    Lauren A. Mitchell

    2014-08-01

    Full Text Available In the title molecule, C24H23N3O3S2, the benzothiadiazole ring system is essentially planar, with an r.m.s. deviation of 0.020 (8 Å. The thiophene and hydroxy-substitiuted rings form dihedral angles of 23.43 (9 and 35.45 (9°, respectively, with the benzothiadiazole ring system. An intramolecular O—H...N hydrogen bond is observed. In the crystal, weak C—H...O hydrogen bonds and π–π stacking interactions [centroid–centroid distance = 3.880 (3 Å] link molecules into chains along [100]. In addition, there are short S...S contacts [3.532 (3 Å] which link these chains, forming a two-dimensional network parallel to (010.

  14. SU-D-213-04: Accounting for Volume Averaging and Material Composition Effects in An Ionization Chamber Array for Patient Specific QA

    Energy Technology Data Exchange (ETDEWEB)

    Fugal, M; McDonald, D; Jacqmin, D; Koch, N; Ellis, A; Peng, J; Ashenafi, M; Vanek, K [Medical University of South Carolina, Charleston, SC (United States)

    2015-06-15

    Purpose: This study explores novel methods to address two significant challenges affecting measurement of patient-specific quality assurance (QA) with IBA’s Matrixx Evolution™ ionization chamber array. First, dose calculation algorithms often struggle to accurately determine dose to the chamber array due to CT artifact and algorithm limitations. Second, finite chamber size and volume averaging effects cause additional deviation from the calculated dose. Methods: QA measurements were taken with the Matrixx positioned on the treatment table in a solid-water Multi-Cube™ phantom. To reduce the effect of CT artifact, the Matrixx CT image set was masked with appropriate materials and densities. Individual ionization chambers were masked as air, while the high-z electronic backplane and remaining solid-water material were masked as aluminum and water, respectively. Dose calculation was done using Varian’s Acuros XB™ (V11) algorithm, which is capable of predicting dose more accurately in non-biologic materials due to its consideration of each material’s atomic properties. Finally, the exported TPS dose was processed using an in-house algorithm (MATLAB) to assign the volume averaged TPS dose to each element of a corresponding 2-D matrix. This matrix was used for comparison with the measured dose. Square fields at regularly-spaced gantry angles, as well as selected patient plans were analyzed. Results: Analyzed plans showed improved agreement, with the average gamma passing rate increasing from 94 to 98%. Correction factors necessary for chamber angular dependence were reduced by 67% compared to factors measured previously, indicating that previously measured factors corrected for dose calculation errors in addition to true chamber angular dependence. Conclusion: By comparing volume averaged dose, calculated with a capable dose engine, on a phantom masked with correct materials and densities, QA results obtained with the Matrixx Evolution™ can be significantly improved. In addition, necessary correction factors are reduced, allowing for more reliable and meaningful patient-specific QA measurements.

  15. SU-C-213-05: Evaluation of a Composite Copper-Plastic Material for a 3D Printed Radiation Therapy Bolus

    Energy Technology Data Exchange (ETDEWEB)

    Vitzthum, L; Ehler, E; Sterling, D; Reynolds, T; Higgins, P; Dusenbery, K [University of Minnesota, Minneapolis, MN (United States)

    2015-06-15

    Purpose: To evaluate a novel 3D printed bolus fabricated from a copper-plastic composite as a thin flexible, custom fitting device that can replicate doses achieved with conventional bolus techniques. Methods: Two models of bolus were created on a 3D printer using a composite copper-PLA/PHA. Firstly, boluses were constructed at thicknesses of 0.4, 0.6 and 0.8 mm. Relative dose measurements were performed under the bolus with an Attix Chamber as well as with radiochromic film. Results were compared to superficial Attix Chamber measurements in a water equivalent material to determine the dosimetric water equivalence of the copper-PLA/PHA plastic. Secondly, CT images of a RANDO phantom were used to create a custom fitting bolus across the anterolateral scalp. Surface dose with the bolus placed on the RANDO phantom was measured with radiochromic film at tangential angles with 6, 10, 10 flattening filter free (FFF) and 18 MV photon beams. Results: Mean surface doses for 6, 10, 10FFF and 18 MV were measured as a percent of Dmax for the flat bolus devices of each thickness. The 0.4 mm thickness bolus was determined to be near equivalent to 2.5 mm depth in water for all four energies. Surface doses ranged from 59–63% without bolus and 85–90% with the custom 0.4 mm copper-plastic bolus relative to the prescribed dose for an oblique tangential beam arrangement on the RANDO phantom. Conclusion: Sub-millimeter thickness, 3D printed composite copper-PLA/PHA bolus can provide a build-up effect equivalent to conventional bolus. At this thickness, the 3D printed bolus allows a level of flexure that may provide more patient comfort than current 3D printing materials used in bolus fabrication while still retaining the CT based custom patient shape. Funding provided by an intra-department grant of the University of Minnesota Department of Radiation Oncology.

  16. SU-C-213-04: Application of Depth Sensing and 3D-Printing Technique for Total Body Irradiation (TBI) Patient Measurement and Treatment Planning

    Energy Technology Data Exchange (ETDEWEB)

    Lee, M; Suh, T [Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of); Research Institute of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of); Han, B; Xing, L [Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, CA (United States); Jenkins, C [Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, CA (United States); Department of Mechanical Engineering, Stanford University, Palo Alto, CA (United States)

    2015-06-15

    Purpose: To develop and validate an innovative method of using depth sensing cameras and 3D printing techniques for Total Body Irradiation (TBI) treatment planning and compensator fabrication. Methods: A tablet with motion tracking cameras and integrated depth sensing was used to scan a RANDOTM phantom arranged in a TBI treatment booth to detect and store the 3D surface in a point cloud (PC) format. The accuracy of the detected surface was evaluated by comparison to extracted measurements from CT scan images. The thickness, source to surface distance and off-axis distance of the phantom at different body section was measured for TBI treatment planning. A 2D map containing a detailed compensator design was calculated to achieve uniform dose distribution throughout the phantom. The compensator was fabricated using a 3D printer, silicone molding and tungsten powder. In vivo dosimetry measurements were performed using optically stimulated luminescent detectors (OSLDs). Results: The whole scan of the anthropomorphic phantom took approximately 30 seconds. The mean error for thickness measurements at each section of phantom compare to CT was 0.44 ± 0.268 cm. These errors resulted in approximately 2% dose error calculation and 0.4 mm tungsten thickness deviation for the compensator design. The accuracy of 3D compensator printing was within 0.2 mm. In vivo measurements for an end-to-end test showed the overall dose difference was within 3%. Conclusion: Motion cameras and depth sensing techniques proved to be an accurate and efficient tool for TBI patient measurement and treatment planning. 3D printing technique improved the efficiency and accuracy of the compensator production and ensured a more accurate treatment delivery.

  17. Lifestyle and the importance of health education in the cardiac rehabilitation after myocardial revascularization surgery - doi:10.5020/18061230.2007.p213

    Directory of Open Access Journals (Sweden)

    Denise Gonçaleves Moura Pinheiro

    2012-01-01

    Full Text Available In the treatment of ischemic cardiopathy, the prevention has a main role and the modifications in the lifestyle are indispensable for the good prognosis of the disease. The goal of the study was to describe the lifestyle regarding the prevalence of cardiovascular risk factors, such as smoking, alcohol consumption, dietary habits and sedentary behaviors before myocardial revascularization surgery and during the period of cardiac rehabilitation in a private institution that did not comprise structured health education activities. This was a retrospective, observational study, with a qualitative approach, held with 50 patients submitted to cardiac rehabilitation (36 men and 14 women; age 61±12.74 years. The data were collected from clinical records of the pre-cardiac rehabilitation evaluation which consisted of clinical data and information referring to the patients’ lifestyle. Amongst the most prevalent co-morbidities in the sample, there were: the hypertension (n=24; 48%, the diabetes mellitus (n=18; 36% and dyslipidemias (n=17; 34%. A high rate of smoke cessation (100% and 58% of sedentary behaviors (n=29 was observed after the cardiac surgery. This same number (n=29; 58% referred to have adhered to changes in dietary habits after the myocardial acute infarct. There was also an increase in the prevalence of alcohol consumption (n=21; 42% after myocardial revascularization. We conclude with this research that a cardiac rehabilitation program should provide to their patients, health education actions, for a necessary and real change in lifestyle habits, with the presence of a multidisciplinary team.

  18. Targeted alpha-therapy using [Bi-213]anti-CD20 as novel treatment option for radio- and chemoresistant non-Hodgkin lymphoma cells

    OpenAIRE

    Roscher, Mareike; Hormann, Inis; Leib, Oliver; Marx, Sebastian; Moreno, Josue; Miltner, Erich; Friesen, Claudia

    2013-01-01

    Radioimmunotherapy (RIT) is an emerging treatment option for non-Hodgkin lymphoma (NHL) producing higher overall response and complete remission rates compared with unlabelled antibodies. However, the majority of patients treated with conventional or myeloablative doses of radiolabelled antibodies relapse. The development of RIT with alpha-emitters is attractive for a variety of cancers because of the high linear energy transfer (LET) and short path length of alpha-radiation in human tissue, ...

  19. Caloric Intake from Fast Food among Children and Adolescents in the United States, 2011-2012. NCHS Data Brief. Number 213

    Science.gov (United States)

    Vikraman, Sundeep; Fryar, Cheryl D.; Ogden, Cynthia L.

    2015-01-01

    Consumption of fast food has been linked to weight gain in adults. Fast food has also been associated with higher caloric intake and poorer diet quality in children and adolescents. From 1994 through 2006, caloric intake from fast food increased from 10% to 13% among children aged 2-18 years. This report presents the most recent data on the…

  20. Low cycle fatigue behaviour of neutron irradiated copper alloys at 250 and 350 deg. C. (ITER R and D Task no. T213)[International Thermonuclear Experimental Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Singh, B.N.; Stubbins, J.F. [Illinois Univ., Dept. of Nuclear Engineering, Illinois (United States); Toft, P

    2000-03-15

    The fatigue behaviour of a dispersion strengthened and a precipitation hardened copper alloys was investigated with and without irradiation exposure. Fatigue specimens of these alloys were irradiated with fission neutrons in the DR-3 reactor at Risoe with a flux of {approx}2.5 x 10{sup 17} n/m{sup 2}s (E> 1 MeV) to influence levels of 1.0 - 1.5 x 10{sup 24} n/m{sup 2} (E> 1 MeV) at 250 and 350 deg. C. These irradiations were carried out in temperature controlled rigs where the irradiation temperature was monitored and controlled continuously throughout the whole irradiation experiment. Both unirradiated and irradiated specimens were fatigue tested in vacuum at the irradiation temperatures of 250 and 350 deg. C in a strain controlled mode with a loading frequency of 0.5Hz. Post-fatigue microstructures were examined using transmission electron microscopy and the fracture surfaces were investigated using scanning electron microscope. The present investigations demonstrated that the fatigue life decreases with increasing temperature and that the exposure to neutron irradiation causes further degradation in fatigue life at both temperatures. These results are discussed in terms of the observed post-fatigue microstructures and the fracture surface morphology. Finally, the main conclusions and their implications are summarised. (au)

  1. SU-D-213-04: Accounting for Volume Averaging and Material Composition Effects in An Ionization Chamber Array for Patient Specific QA

    International Nuclear Information System (INIS)

    Purpose: This study explores novel methods to address two significant challenges affecting measurement of patient-specific quality assurance (QA) with IBA’s Matrixx Evolution™ ionization chamber array. First, dose calculation algorithms often struggle to accurately determine dose to the chamber array due to CT artifact and algorithm limitations. Second, finite chamber size and volume averaging effects cause additional deviation from the calculated dose. Methods: QA measurements were taken with the Matrixx positioned on the treatment table in a solid-water Multi-Cube™ phantom. To reduce the effect of CT artifact, the Matrixx CT image set was masked with appropriate materials and densities. Individual ionization chambers were masked as air, while the high-z electronic backplane and remaining solid-water material were masked as aluminum and water, respectively. Dose calculation was done using Varian’s Acuros XB™ (V11) algorithm, which is capable of predicting dose more accurately in non-biologic materials due to its consideration of each material’s atomic properties. Finally, the exported TPS dose was processed using an in-house algorithm (MATLAB) to assign the volume averaged TPS dose to each element of a corresponding 2-D matrix. This matrix was used for comparison with the measured dose. Square fields at regularly-spaced gantry angles, as well as selected patient plans were analyzed. Results: Analyzed plans showed improved agreement, with the average gamma passing rate increasing from 94 to 98%. Correction factors necessary for chamber angular dependence were reduced by 67% compared to factors measured previously, indicating that previously measured factors corrected for dose calculation errors in addition to true chamber angular dependence. Conclusion: By comparing volume averaged dose, calculated with a capable dose engine, on a phantom masked with correct materials and densities, QA results obtained with the Matrixx Evolution™ can be significantly improved. In addition, necessary correction factors are reduced, allowing for more reliable and meaningful patient-specific QA measurements

  2. Radio observations of the TeV source HESS J1943+213: a new case of a pulsar wind nebula?

    CERN Document Server

    Gabanyi, K E; Giacani, E; Paragi, Z; Pidopryhora, Y; Frey, S

    2011-01-01

    Recently, the H.E.S.S. Collaboration discovered a very high energy gamma-ray point source close to the Galactic plane. They offered three possible explanations for the nature of the source: a gamma-ray binary, a pulsar wind nebula, or a BL Lac object. They concluded that the observations favoured an extreme BL Lac object interpretation. We investigated the nature of the radio source reported as the counterpart of the very high energy gamma-ray source. We performed high-resolution radio interferometric observations with the European Very Long Baseline Interferometry Network at a frequency of 1.6 GHz on 2011 May 18. We also reanalysed archival 1.4-GHz radio continuum and HI spectral line data taken with the Very Large Array. The accurate position of the radio source, as observed with EVN, is ~ 4" off from the one obtained in the NRAO VLA Sky Survey. The new position is in excellent agreement with that of the proposed X-ray counterpart of the TeV source. From HI absorption data, a distance of about 11.5 +/- 1.5 ...

  3. 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis

    Directory of Open Access Journals (Sweden)

    Zhao Lijing

    2012-11-01

    Full Text Available Abstract Background Recent studies have indicated that the nuclear RNA-binding protein RBM5 has the ability to modulate apoptosis and suppress tumor growth. The aim of this study is to investigate the expression of RBM5 in human prostate cancer and its mechanism of tumor suppression. Methods The expression of RBM5 protein in cancerous prostatic tissues and normal tissues was examined by IHC. PC-3 cell line was used to determine the apoptotic function of RBM5 in vitro. PC-3 cells were transiently transfected with pcDNA3.1-RBM5. Cell viability was determined by MTT assay. Rhodamine 123 staining and Annexin V analysis were performed to observe the apoptotic activity of PC-3 cells overexpressing RBM5. Expression of apoptosis-related genes was assessed by western blot. Results The expression of RBM5 protein was significantly decreased in cancerous prostatic tissues compared to the normal tissues. PC-3 cells overexpressing RBM5 showed not only significant growth inhibition compared with the vector controls, but also dysfunction of mitochondrial membrane potential and increased apoptotic activity. To further define RBM5 function in apoptotic pathways, we investigated differential expression profiles of various BH3-only proteins including Bid, Bad, and Bim, and apoptosis regulatory proteins include P53, cleaved caspase9, and cleaved caspase3. We found that the expression of both BH3-only proteins and apoptosis regulatory proteins was increased in RBM5 transfected cells. Conclusion The expression of RBM5 protein was significantly decreased in cancerous prostatic tissues, which suggests that RBM5 plays an important role in the pathogenesis of prostate cancer. RBM5 may induce the apoptosis of prostate cancer PC-3 cells by modulating the mitochondrial apoptotic pathway, and thus RBM5 might be a promising target for gene therapy on prostate cancer.

  4. NRC review of Electric Power Research Institute's advanced light water reactor utility requirements document. Passive plant designs, chapters 2-13, project number 669

    International Nuclear Information System (INIS)

    The Electric Power Research Institute (EPRI) is preparing a compendium of technical requirements, referred to as the open-quotes Advanced Light Water Reactor [ALWR] Utility Requirements Documentclose quotes, that is acceptable to the design of an ALWR power plant. When completed, this document is intended to be a comprehensive statement of utility requirements for the design, construction, and performance of an ALWR power plant for the 1990s and beyond. The Requirements Document consists of three volumes. Volume I, open-quotes ALWR Policy and Summary of Top-Tier Requirementsclose quotes, is a management-level synopsis of the Requirements Document, including the design objectives and philosophy, the overall physical configuration and features of a future nuclear plant design, and the steps necessary to take the proposed ALWR design criteria beyond the conceptual design state to a completed, functioning power plant. Volume II consists of 13 chapters and contains utility design requirements for an evolutionary nuclear power plant [approximately 1350 megawatts-electric (MWe)]. Volume III contains utility design requirements for nuclear plants for which passive features will be used in their designs (approximately 600 MWe). In April 1992, the staff of the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, issued Volume 1 and Volume 2 (Parts 1 and 2) of its safety evaluation report (SER) to document the results of its review of Volumes 1 and 2 of the Requirements Document. Volume 1, open-quotes NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document - Program Summaryclose quotes, provided a discussion of the overall purpose and scope of the Requirements Document, the background of the staff's review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review

  5. SU-B-213-00: Education Council Symposium: Accreditation and Certification: Establishing Educational Standards and Evaluating Candidates Based on these Standards

    International Nuclear Information System (INIS)

    The North American medical physics community validates the education received by medical physicists and the clinical qualifications for medical physicists through accreditation of educational programs and certification of medical physicists. Medical physics educational programs (graduate education and residency education) are accredited by the Commission on Accreditation of Medical Physics Education Programs (CAMPEP), whereas medical physicists are certified by several organizations, the most familiar of which is the American Board of Radiology (ABR). In order for an educational program to become accredited or a medical physicist to become certified, the applicant must meet certain specified standards set by the appropriate organization. In this Symposium, representatives from both CAMPEP and the ABR will describe the process by which standards are established as well as the process by which qualifications of candidates for accreditation or certification are shown to be compliant with these standards. The Symposium will conclude with a panel discussion. Learning Objectives: Recognize the difference between accreditation of an educational program and certification of an individual Identify the two organizations primarily responsible for these tasks Describe the development of educational standards Describe the process by which examination questions are developed GS is Executive Secretary of CAMPEP

  6. SU-D-213-03: Towards An Optimized 3D Scintillation Dosimetry Tool for Quality Assurance of Dynamic Radiotherapy Techniques

    Energy Technology Data Exchange (ETDEWEB)

    Rilling, M [Département de physique, de génie physique et d’optique, Université Laval, Quebec City, QC (Canada); Centre de Recherche sur le Cancer, Hôtel-Dieu de Québec, Quebec City, QC (Canada); Département de radio-oncologie, CHU de Québec, Quebec City, QC (Canada); Center for Optics, Photonics and Lasers, Université Laval, Quebec City, QC, CA (Canada); Goulet, M [Département de radio-oncologie, CHU de Québec, Quebec City, QC (Canada); Thibault, S [Département de physique, de génie physique et d’optique, Université Laval, Quebec City, QC (Canada); Center for Optics, Photonics and Lasers, Université Laval, Quebec City, QC, CA (Canada); Archambault, L [Département de physique, de génie physique et d’optique, Université Laval, Quebec City, QC (Canada); Centre de Recherche sur le Cancer, Hôtel-Dieu de Québec, Quebec City, QC (Canada); Département de radio-oncologie, CHU de Québec, Quebec City, QC (Canada)

    2015-06-15

    Purpose: The purpose of this work is to simulate a multi-focus plenoptic camera used as the measuring device in a real-time three-dimensional scintillation dosimeter. Simulating and optimizing this realistic optical system will bridge the technological gap between concept validation and a clinically viable tool that can provide highly efficient, accurate and precise measurements for dynamic radiotherapy techniques. Methods: The experimental prototype, previously developed for proof of concept purposes, uses an off-the-shelf multi-focus plenoptic camera. With an array of interleaved microlenses of different focal lengths, this camera records spatial and angular information of light emitted by a plastic scintillator volume. The three distinct microlens focal lengths were determined experimentally for use as baseline parameters by measuring image-to-object magnification for different distances in object space. A simulated plenoptic system was implemented using the non-sequential ray tracing software Zemax: this tool allows complete simulation of multiple optical paths by modeling interactions at interfaces such as scatter, diffraction, reflection and refraction. The active sensor was modeled based on the camera manufacturer specifications by a 2048×2048, 5 µm-pixel pitch sensor. Planar light sources, simulating the plastic scintillator volume, were employed for ray tracing simulations. Results: The microlens focal lengths were determined to be 384, 327 and 290 µm. A realistic multi-focus plenoptic system, with independently defined and optimizable specifications, was fully simulated. A f/2.9 and 54 mm-focal length Double Gauss objective was modeled as the system’s main lens. A three-focal length hexagonal microlens array of 250-µm thickness was designed, acting as an image-relay system between the main lens and sensor. Conclusion: Simulation of a fully modeled multi-focus plenoptic camera enables the decoupled optimization of the main lens and microlens specifications. This work leads the way to improving the 3D dosimeter’s achievable resolution, efficiency and build for providing a quality assurance tool fully meeting clinical needs. M.R. is financially supported by a Master’s Canada Graduate Scholarship from the NSERC. This research is also supported by the NSERC Industrial Research Chair in Optical Design.

  7. SU-C-213-01: 3D Printed Patient Specific Phantom Composed of Bone and Soft Tissue Substitute Plastics for Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ehler, E; Sterling, D; Higgins, P [University of Minnesota, Minneapolis, MN (United States)

    2015-06-15

    Purpose: 3D printed phantoms constructed of multiple tissue approximating materials could be useful in both clinical and research aspects of radiotherapy. This work describes a 3D printed phantom constructed with tissue substitute plastics for both bone and soft tissue; air cavities were included as well. Methods: 3D models of an anonymized nasopharynx patient were generated for air cavities, soft tissues, and bone, which were segmented by Hounsfield Unit (HU) thresholds. HU thresholds were chosen to define air-to-soft tissue boundaries of 0.65 g/cc and soft tissue-to-bone boundaries of 1.18 g/cc based on clinical HU to density tables. After evaluation of several composite plastics, a bone tissue substitute was identified as an acceptable material for typical radiotherapy x-ray energies, composed of iron and PLA plastic. PET plastic was determined to be an acceptable soft tissue substitute. 3D printing was performed on a consumer grade dual extrusion fused deposition model 3D printer. Results: MVCT scans of the 3D printed heterogeneous phantom were acquired. Rigid image registration of the patient and the 3D printed phantom scans was performed. The average physical density of the soft tissue and bone regions was 1.02 ± 0.08 g/cc and 1.39 ± 0.14 g/cc, respectively, for the patient kVCT scan. In the 3D printed phantom MVCT scan, the average density of the soft tissue and bone was 1.01 ± 0.09 g/cc and 1.44 ± 0.12 g/cc, respectively. Conclusion: A patient specific phantom, constructed of heterogeneous tissue substitute materials was constructed by 3D printing. MVCT of the 3D printed phantom showed realistic tissue densities were recreated by the 3D printing materials. Funding provided by intra-department grant by University of Minnesota Department of Radiation Oncology.

  8. PMK-2, the First Integral Thermal-Hydraulics Tests for the Safety Evaluation of VVER-440/213 Nuclear Power Plants

    Directory of Open Access Journals (Sweden)

    Gy. Ézsöl

    2012-01-01

    Full Text Available The PMK-2 facility is a full-pressure thermal-hydraulic model of the primary and partly the secondary circuit of the VVER-type units of Paks NPP. The facility was the first integral-type facility for VVERs. The PMK-2 was followed later by the PACTEL (for VVER-440, the ISB, and PSB for VVER-1000. Since the startup of the facility in 1985, 55 experiments have been performed primarily in international frameworks with the participation of experts from 29 European and overseas countries forming a scientific school to better understand VVER system behaviour and reach a high level of modelling of accident sequences. The ATHLET, CATHARE, and RELAP5 codes have been validated including both qualitative and quantitative assessments. The former was almost exclusively applied to the early phase of validation by integral experiments, while the quantitative assessments have been performed by the Fast Fourier Transform Based Method. Paper gives comprehensive information on the design features of PMK-2 facility with a special respect to the representativeness of phenomena, the experiments performed, and the results of the validation of ATHLET, CATHARE, and RELAP5 codes. Safety significance of the PMK-2 projects is also discussed.

  9. SU-D-213-05: Design, Evaluation and First Applications of a Off-Site State-Of-The-Art 3D Dosimetry System

    International Nuclear Information System (INIS)

    Purpose: To design, construct and commission a prototype in-house three dimensional (3D) dose verification system for stereotatic body radiotherapy (SBRT) verification at an off-site partner institution. To investigate the potential of this system to achieve sufficient performance (1mm resolution, 3% noise, within 3% of true dose reading) for SBRT verification. Methods: The system was designed utilizing a parallel ray geometry instigated by precision telecentric lenses and an LED 630nm light source. Using a radiochromic dosimeter, a 3D dosimetric comparison with our gold-standard system and treatment planning software (Eclipse) was done for a four-field box treatment, under gamma passing criteria of 3%/3mm/10% dose threshold. Post off-site installation, deviations in the system’s dose readout performance was assessed by rescanning the four-field box irradiated dosimeter and using line-profiles to compare on-site and off-site mean and noise levels in four distinct dose regions. As a final step, an end-to-end test of the system was completed at the off-site location, including CT-simulation, irradiation of the dosimeter and a 3D dosimetric comparison of the planned (Pinnacle3) to delivered dose for a spinal SBRT treatment(12 Gy per fraction). Results: The noise level in the high and medium dose regions of the four field box treatment was relatively 5% pre and post installation. This reflects the reduction in positional uncertainty through the new design. This At 1mm dose voxels, the gamma pass rates(3%,3mm) for our in-house gold standard system and the off-site system were comparable at 95.8% and 93.2% respectively. Conclusion: This work will describe the end-to-end process and results of designing, installing, and commissioning a state-of-the-art 3D dosimetry system created for verification of advanced radiation treatments including spinal radiosurgery

  10. Improved HPLC-ECD analysis of mitomycin C, porfiromycin, VP 16-213 and VM 26 by implantation of software filters.

    Science.gov (United States)

    Ploegmakers, H H; Mertens, M J; van Oort, W J

    1987-01-01

    In high performance liquid chromatography with electrochemical detection (HPLC/ECD) much attention has been paid to the performance of the applied detection system with respect to reliability and sensitivity. In general, insufficient attention has been paid to relatively easy to implant devices for improved collection and handling of detection signals. Four models of software filtering are studied and compared with hardware filtering. In the investigated chromatographic-electrochemical system, off-line parabolic filtering after on-line averaging of sixteen measurements proved to be the system of first choice, with respect to execution time, noise level, signal to noise ratio, peak height and resolution. PMID:3126702

  11. SU-C-213-05: Evaluation of a Composite Copper-Plastic Material for a 3D Printed Radiation Therapy Bolus

    International Nuclear Information System (INIS)

    Purpose: To evaluate a novel 3D printed bolus fabricated from a copper-plastic composite as a thin flexible, custom fitting device that can replicate doses achieved with conventional bolus techniques. Methods: Two models of bolus were created on a 3D printer using a composite copper-PLA/PHA. Firstly, boluses were constructed at thicknesses of 0.4, 0.6 and 0.8 mm. Relative dose measurements were performed under the bolus with an Attix Chamber as well as with radiochromic film. Results were compared to superficial Attix Chamber measurements in a water equivalent material to determine the dosimetric water equivalence of the copper-PLA/PHA plastic. Secondly, CT images of a RANDO phantom were used to create a custom fitting bolus across the anterolateral scalp. Surface dose with the bolus placed on the RANDO phantom was measured with radiochromic film at tangential angles with 6, 10, 10 flattening filter free (FFF) and 18 MV photon beams. Results: Mean surface doses for 6, 10, 10FFF and 18 MV were measured as a percent of Dmax for the flat bolus devices of each thickness. The 0.4 mm thickness bolus was determined to be near equivalent to 2.5 mm depth in water for all four energies. Surface doses ranged from 59–63% without bolus and 85–90% with the custom 0.4 mm copper-plastic bolus relative to the prescribed dose for an oblique tangential beam arrangement on the RANDO phantom. Conclusion: Sub-millimeter thickness, 3D printed composite copper-PLA/PHA bolus can provide a build-up effect equivalent to conventional bolus. At this thickness, the 3D printed bolus allows a level of flexure that may provide more patient comfort than current 3D printing materials used in bolus fabrication while still retaining the CT based custom patient shape. Funding provided by an intra-department grant of the University of Minnesota Department of Radiation Oncology

  12. SU-C-213-01: 3D Printed Patient Specific Phantom Composed of Bone and Soft Tissue Substitute Plastics for Radiation Therapy

    International Nuclear Information System (INIS)

    Purpose: 3D printed phantoms constructed of multiple tissue approximating materials could be useful in both clinical and research aspects of radiotherapy. This work describes a 3D printed phantom constructed with tissue substitute plastics for both bone and soft tissue; air cavities were included as well. Methods: 3D models of an anonymized nasopharynx patient were generated for air cavities, soft tissues, and bone, which were segmented by Hounsfield Unit (HU) thresholds. HU thresholds were chosen to define air-to-soft tissue boundaries of 0.65 g/cc and soft tissue-to-bone boundaries of 1.18 g/cc based on clinical HU to density tables. After evaluation of several composite plastics, a bone tissue substitute was identified as an acceptable material for typical radiotherapy x-ray energies, composed of iron and PLA plastic. PET plastic was determined to be an acceptable soft tissue substitute. 3D printing was performed on a consumer grade dual extrusion fused deposition model 3D printer. Results: MVCT scans of the 3D printed heterogeneous phantom were acquired. Rigid image registration of the patient and the 3D printed phantom scans was performed. The average physical density of the soft tissue and bone regions was 1.02 ± 0.08 g/cc and 1.39 ± 0.14 g/cc, respectively, for the patient kVCT scan. In the 3D printed phantom MVCT scan, the average density of the soft tissue and bone was 1.01 ± 0.09 g/cc and 1.44 ± 0.12 g/cc, respectively. Conclusion: A patient specific phantom, constructed of heterogeneous tissue substitute materials was constructed by 3D printing. MVCT of the 3D printed phantom showed realistic tissue densities were recreated by the 3D printing materials. Funding provided by intra-department grant by University of Minnesota Department of Radiation Oncology

  13. HP213Cr无缝钢管的研制开发%R & D of HP2 13Cr Seamless Steel Pipe

    Institute of Scientific and Technical Information of China (English)

    康喜唐; 聂飞

    2015-01-01

    从成分设计、冶炼、径锻、挤压及热处理工艺流程等方面,详细介绍了采用“热挤压+调质热处理”工艺生产HP2 13Cr无缝钢管的方法.实物性能检测结果表明:该工艺生产的HP2 13Cr无缝钢管力学性能及金相组织控制较好,完全满足ISO 13680∶2010标准要求,在高含CO2、H2S酸性环境中均为轻度腐蚀,耐蚀性好.

  14. 用H2/13CO2呼吸试验检测乳糖不耐受者呼气成分的研究%Study on the expired gas of subjects with lactose intolerance by using H2/13CO2 breath test

    Institute of Scientific and Technical Information of China (English)

    钟燕; R.J.Vonk

    2002-01-01

    为了找出能反映乳糖在肠道内分解吸收程度的良好指标,本研究根据乳糖负荷试验结果对筛选出的成人乳糖吸收不良者、轻度及重度乳糖不耐受者,研究乳糖不耐受症状与呼气成分之间的关系.在给予13C-乳糖25g之后,收集6小时的呼气样本,分别采用气相色谱法和气相同位素质谱法测定各时间点呼气中的H2浓度和13CO2含量并计算其累积呼出量;通过问卷调查摄入乳糖后12小时内出现的不适症状及其严重程度.结果显示:乳糖不耐受组呼气H2浓度升高达到峰值时间较吸收不良组快,且峰值显著高于吸收不良组(P<0.01);6小时累积H2呼出量显著高于吸收不良组(P<0.01);口-结肠转运时间(OCTT)与不耐受症状评分呈负相关(r=-0.705,P<0.01);各时间点13CO2的呼出量以及6小时累积呼出量在乳糖不耐受组和吸收不良组之间无显著性差异.提示呼气中H2浓度与不耐受症状的严重程度有相关关系,可以反映出乳糖在小肠内的吸收程度;口-结肠转运时间与乳糖不耐受症状之间有一定相关关系;而呼气13CO2的含量与不耐受症状之间未显示出相关关系.

  15. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    . Moreover, the Panel reconsidered the available data on p-mentha-1,4(8)-dien-3-one [FL-no: 07.127], based on new data on the structurally related substance pulegone, and concluded that additional genotoxicity data are needed to rule out the concern for genotoxicity of p-mentha-1,4(8)-dien-3-one [FL-no: 07.127]....

  16. 治疗仪联合川参通局部注药治疗前列腺增生症213例报道%Study on Clinical Effect of Method of the Treatment Instrument combined with Partial Injection of Chuanshentong Treatment for Benign Prostatic Hyperplasia Report of 213 Cases

    Institute of Scientific and Technical Information of China (English)

    邢子龙

    2012-01-01

      Objective To Study on clinical effect and drug delivery method of method of the treatment instrument combined with partial injection of chuan shen tong treatment for benign prostatic hyperplasia Methods Method of the treatment instrument massage prostate through rectum combined with partial injection of Chinese Native Medicine in perineum directly with the number 5 needle. Results The prostate volume is reduced, the total efficiency of 94.6%. Conclusion The treatment instrument combined with partial injection of chuan shen tong treatment for benign prostatic hyperplasia is a major breakthrough, worthy of clinical use.%  目的探讨治疗仪联合川参通局部注药治疗前列腺增生症的给药方法及临床疗效.方法治疗仪经肛门直肠按摩联合会阴部直接用5号特制针头注射中药制剂.结果前列腺体积缩小,总有效率94.6%.结论治疗仪联合川参通局部注药是治疗前列腺增生症的重大突破,直得临床推广使用.

  17. Corrosión por depósitos salinos de los aceros SA213-T22 y SA213-TP347H en presencia de una mezcla 80%V2O5-20%Na2SO4-20%Na2SO4

    OpenAIRE

    Romero, M. A.; Malo, J. M.; Gaona, C.; Martínez-Villafañe, A.; Almeraya, F.

    1998-01-01

    Many hot corrosion problems in industrial and utility boilers are caused by molten salts. The corrosion processes which occur in salts are of an electrochemical nature, and so they can be studied using electrochemical test methods. In this research, electrochemical techniques in molten salt systems have been used for the measurements of molten corrosion processes. Electrochemical test methods are described here for a salt mixture of 80%V2O5-20%Na2SO4 at 540-680°C. To establish better the elec...

  18. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Science.gov (United States)

    2010-01-01

    ... Category 1(TBq) Category 1(Ci) Category 2(TBq) Category 2(Ci) Actinium-227 20 540 0.2 5.4 Americium-241 60... 2 54 Strontium-90 1,000 27,000 10 270 Thorium-228 20 540 0.2 5.4 Thorium-229 20 540 0.2 5.4...

  19. I. The metabolic properties of plutonium and allied materials

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  20. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  1. Protein (Cyanobacteria): 88129 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available Synechococcus sp. JA-2-3B'a(2-13) MQSMAESRDPDTPPQDRRRLIREVAGWLAMLGVLIPGLQRFYMGHQRWGWGYLVAGLMVFVPSIPLQILSYGVRALCLLEGLWILTMSNADFDFRFNRELIELEWTSVEGREARDPEQQLESLLKQGLITRAEYEERRRQIRKIS ...

  2. Protein (Cyanobacteria): 85747 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available Synechococcus sp. JA-2-3B'a(2-13) MFRRVQRECIRIGSGRISLFCSASATMTPEQEQWLIQAIQELKASQRELQASQRELQAAQQELRLVQQNQQVLIQELREGQAMLAQFFRESMDRFDERTRAIERRTEAVERRTEALERRTDQMAEEMREIRQEIRDLRRDFLERR ...

  3. Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons

    DEFF Research Database (Denmark)

    Brekke, Eva Marie; Walls, Anne Byriel; Schousboe, Arne;

    2012-01-01

    of (13)C-labeled glucose via the PPP does not appear to contribute to the production of releasable lactate, it contributes to labeling of tricarboxylic acid (TCA) cycle intermediates and related amino acids. Based on glutamate isotopomers, it was calculated that PPP activity accounts for ~6% of glucose...

  4. HAZARD CHARACTERISTICS OF THE DEBRIS FLOWS AT THE MAOJIAWAN TUNNEL GULLIES ALONG DUWEN ROAD%G213都汶路毛家湾隧道口沟泥石流灾害特征分析

    Institute of Scientific and Technical Information of China (English)

    杨金川; 王毅; 周勇

    2013-01-01

    毛家湾隧道口沟于2010年8月14日和2011年7月3日两次暴发泥石流.在描述其运动和堆积特征的基础上,从主沟和支沟堆积物特征、地形条件及运动参数计算方面,分析形成这些特征的原因,并提出该泥石流沟的演变趋势.

  5. The "RA" Expeditions: The Archaeological and Anthropological Background. The "RA" Expeditions: The Coriolis Effect. The "RA" Expeditions: The Papyrus Reed. Learning Experiences for Coastal and Oceanic Awareness Studies, Nos. 211, 212, 213. [Project COAST].

    Science.gov (United States)

    Delaware Univ., Newark. Coll. of Education.

    Included are three units related to coastal and oceanic awareness. These are: (1) The "RA" Expeditions: The Archaeological and Anthropological Background; (2) The "RA" Expeditions: The Coriolis Effect; and (3) The "RA" Expeditions: The Papyrus Reed. Each of the three units are designed for students in grades 6-12. Each unit contains teacher…

  6. « The Sasanian Relashionship with South Arabia: Literary, Epigraphic and Oral Historical Perspectives ». Arabian Archaeology and Epigraphy 37, fasc. 2, 2008, p. 197-213.

    OpenAIRE

    Cuny, Julien

    2013-01-01

    L’A. offre un compendium de trois types de sources différentes concernant l’histoire de l’intervention, de la présence ou de l’impact du pouvoir sassanide en Arabie : les sources littéraires (essentiellement arabo-persanes mais aussi romano-byzantines) ; les quelques inscriptions disponibles, une lapidaire himyarite, et une documentationsigillographique mais qui ne se réfère pas explicitement à l’Arabie; ainsi que la tradition orale omanaise. Néanmoins, le propos de l’A. ne se limite pas à l’...

  7. Review of Recent Literature Relevant to the Environmental Effects of Marine and Hydrokinetic Energy Devices; Task 2.1.3: Effects on Aquatic Organisms - Fiscal Year 2012 Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Kropp, Roy K.

    2013-01-01

    A literature search was conducted by using the Web of Science® databases component of the ISI Web of KnowledgeSM to identify recent articles that would be useful to help assess the potential environmental effects of renewable energy development in the ocean, with emphasis on seabirds and fish. Several relatively recent general review articles that included possible effects on seabirds and fish were examined to begin the search process. From these articles, several general topics of potential environmental effects on seabirds and fish were derived. These topics were used as the primary search factors. Additional sources were identified by cross-checking the Web of Science databases for articles that cited the review articles. It also became clear that the potential effects frequently w

  8. Hyperspectral surface materials map of quadrangles 3666 and 3766, Balkh (219), Mazar-e Sharif (220), Qarqin (213), and Hazara Toghai (214) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Science.gov (United States)

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  9. Hyperspectral surface materials map of quadrangles 3666 and 3766, Balkh (219), Mazar-e Sharif (220), Qarqin (213), and Hazara Toghai (214) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    Science.gov (United States)

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  10. SU-C-213-07: Fabrication and Testing of a 3D-Printed Small Animal Rectal Cooling Device to Evaluate Local Hypothermia as a Radioprotector During Prostate SBRT

    Energy Technology Data Exchange (ETDEWEB)

    Hrycushko, B; Chopra, R; Futch, C; Bing, C; Wodzak, M; Stojadinovic, S; Jiang, S; Medin, P [UT Southwestern Medical Center, Dallas, TX (United States)

    2015-06-15

    Purpose: The protective effects of induced or even accidental hypothermia on the human body are widespread with several medical uses currently under active research. In vitro experiments using human cell lines have shown hypothermia provides a radioprotective effect that becomes more pronounced at large, single-fraction doses common to SBRT treatments. Relevant to prostate SBRT, this work details the fabrication and testing of a 3D-printed cooling device to facilitate the investigation of the radioprotective effect of local hypothermia on the rat rectum. Methods: A 3cm long, two-channel rectal cooling device was designed in SOLIDWORKS CAD for 3D printing. The water intake nozzle is connected to a 1mm diameter brass pipe from which water flows and circulates back around to the exit nozzle. Both nozzles are connected by plastic tubing to a water chiller pump. Following leak-proof testing, fiber optic temperature probes were used to evaluate the temperature over time when placed adjacent to the cooling device within a rat rectum. MRI thermometry characterized the relative temperature distribution in concentric ROIs surrounding the probe. CBCT images from a small-animal irradiator were evaluated for imaging artifacts which could affect Monte Carlo dose calculations during treatment planning. Results: The rectal temperature adjacent to the cooling device decreased from body temperature (37°C) to 15°C in 10–20 minutes from device insertion. Rectal temperature was maintained at 15±3°C during active cooling. MRI thermometry tests revealed a steep temperature gradient with increasing distance from the cooling device, with the desired temperature range maintained within the surrounding few millimeters. Conclusion: A 3D printed rectal cooling device was fabricated for the purpose of inducing local hypothermia in rat rectums. Rectal cooling capabilities were characterized in-vivo to facilitate an investigation of the radioprotective effect of hypothermia for late rectal toxicity following a single large dose of radiation. Funding support provided by RSNA research seed grant.

  11. Gavilán, M. (2006), La transformación de la orientación vocacional. Hacia un nuevo paradigma : Rosario: Editorial Homo Sapiens (213 páginas)

    OpenAIRE

    Müller, Marina

    2007-01-01

    El libro desarrolla una teoría comprensiva y explicativa bien sistematizada, que recurre de continuo a la apoyatura empírica brindada por numerosas investigaciones realizadas por la autora y su equipo de trabajo, en la Universidad Nacional de La Plata. Contribuye a la construcción teórica del dilatado espacio de la orientación, en el cual se entrecruzan diversos saberes inter y transdisciplinarios, y diversos campos de conocimientos, reflexiones y prácticas: la educación, la salud mental, ...

  12. SU-C-213-07: Fabrication and Testing of a 3D-Printed Small Animal Rectal Cooling Device to Evaluate Local Hypothermia as a Radioprotector During Prostate SBRT

    International Nuclear Information System (INIS)

    Purpose: The protective effects of induced or even accidental hypothermia on the human body are widespread with several medical uses currently under active research. In vitro experiments using human cell lines have shown hypothermia provides a radioprotective effect that becomes more pronounced at large, single-fraction doses common to SBRT treatments. Relevant to prostate SBRT, this work details the fabrication and testing of a 3D-printed cooling device to facilitate the investigation of the radioprotective effect of local hypothermia on the rat rectum. Methods: A 3cm long, two-channel rectal cooling device was designed in SOLIDWORKS CAD for 3D printing. The water intake nozzle is connected to a 1mm diameter brass pipe from which water flows and circulates back around to the exit nozzle. Both nozzles are connected by plastic tubing to a water chiller pump. Following leak-proof testing, fiber optic temperature probes were used to evaluate the temperature over time when placed adjacent to the cooling device within a rat rectum. MRI thermometry characterized the relative temperature distribution in concentric ROIs surrounding the probe. CBCT images from a small-animal irradiator were evaluated for imaging artifacts which could affect Monte Carlo dose calculations during treatment planning. Results: The rectal temperature adjacent to the cooling device decreased from body temperature (37°C) to 15°C in 10–20 minutes from device insertion. Rectal temperature was maintained at 15±3°C during active cooling. MRI thermometry tests revealed a steep temperature gradient with increasing distance from the cooling device, with the desired temperature range maintained within the surrounding few millimeters. Conclusion: A 3D printed rectal cooling device was fabricated for the purpose of inducing local hypothermia in rat rectums. Rectal cooling capabilities were characterized in-vivo to facilitate an investigation of the radioprotective effect of hypothermia for late rectal toxicity following a single large dose of radiation. Funding support provided by RSNA research seed grant

  13. Poder sem solidariedade: Foucault e o Colégio Apostólico (Powers without solidarity: Foucault and the Apostolic College - DOI: 10.5752/P.2175-5841.2013v11n29p213

    Directory of Open Access Journals (Sweden)

    Luiz Alexandre Rossi

    2013-03-01

    Full Text Available “Poder sem solidariedade” tem como objetivo abordar um texto emblemático do Novo Testamento, isto é, Marcos 10,32-45 com as ferramentas teóricas da teologia bíblica e da teoria foucaultiana a respeito do poder. A metodologia utilizada é de ordem bibliográfica, a partir do diálogo com textos específicos que exploram o texto de Marcos, a sociedade mediterrânea do primeiro século e textos específicos de Foucault sobre o poder. Percebe-se conclusivamente que ao mesmo tempo em que os discípulos de Jesus procuram reproduzir as relações de poder, Jesus propõe um contra-discurso a fim de vislumbrar o poder como solidariedade a favor da comunidade. A intervenção de Jesus introduzirá um discurso de renúncia à aspiração ao poder assim como uma opção fundamental pelo serviço e pela solidariedade. Diante de dois modelos de concepção e prática do poder veremos uma proposta de inversão dos valores que vigoravam em uma sociedade marcada visceralmente pelas ambições. O jogo do poder também estava presente na comunidade de Jesus e seus discípulos procuravam reproduzir aquilo que já era comum ao tecido social. Palavras-chave: Poder. Autoridade. Cristianismo. Sociedade. Domínio. Abstract “Powers without solidarity” aims to address an emblematic text of the New Testament - Mark 10.32-45 - by using the theoretical tools of biblical theology and Foucault's theory about power. The methodology used is bibliographic out of a dialogue with specific texts that explore the text of Mark, the first-century Mediterranean society and specific texts by Foucault on power. It can be conclusively seen that while the disciples of Jesus seek to reproduce power relations, Jesus proposes a counter-discourse in order to view the power as solidarity in benefit of his community. Jesus´ intervention will introduce a speech that disclaims the aspiration to power and offers a fundamental option for service and solidarity. Given these two models of conception and practice of power, we can see a proposal that reverses the values ​​that prevailed in a society viscerally marked by ambition. The power game was also present in Jesus´ community and his disciples tried to reproduce what was already common to the social culture. Keywords: Power. Authority.  Christianity.  Society. Domain. 

  14. Zircon U–Pb dating by 213 nm Nd. YAG laser ablation inductively coupled plasma mass spectrometry. Optimization of the analytical condition to use NIST SRM 610 for Pb/U fractionation correction

    International Nuclear Information System (INIS)

    We carried out an optimization of analytical parameters for U–Pb zircon dating by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) using a NIST SRM 610 glass. As a result, we obtained the following optimum analytical parameters: laser energy: 11.7 J/cm2, repetition rate: 10 Hz, pre-ablation time: 8 sec, integration time: 10 sec and crater diameter: 25 μm. The average 206Pb/238U ratio of the NIST SRM 610 glass normalized by a 91500 zircon standard under the conditions mentioned above was 0.2236±0.0044 (1σ, N : 87). The median value of this result matches with that of the literature value within range of the analytical precision. Furthermore, the 206Pb/238U weighted mean ages of the Plešovice, OD-3 and Fish Canyon Tuff zircons, having the proposed 206Pb/238U ages of 335.48±0.95 Ma (95% conf., N : 38, MSWD : 1.1), 33.25±0.38 Ma (95% conf., N : 23, MSWD : 1.5), 28.56±0.49 Ma (95% conf., N : 34, MSWD : 5.1), respectively, were measured, normalized by the NIST SRM 610 glass standard. The results were consistent within 1% error range of the recommended values. These results suggest that the matrix effect can be reduced to less than analytical precision on materials with different physical properties under well-optimized analytical conditions. (author)

  15. Laser-assisted ionization in the He(21,3S)+He(1 1S) system: Nonparticipation of the two-step process via the 2 1P level

    International Nuclear Information System (INIS)

    A specific experiment demonstrates unambiguously that the He+ ion signal coming from single collisions between a He*(2 1,3S) beam on a He(11S) target in the presence of a laser field cannot be produced by the two-step process involving 2 1S→2 1P collisional excitation followed by 21P photoionization. This evidence gives support to the conclusion that the laser-assisted collision is the ionizing mechanism

  16. Poly[bis(μ2-1,3-phenylenediamine-κ2N:N′di-μ-thiocyanato-κ2N:S;κ2S:N-cadmium

    Directory of Open Access Journals (Sweden)

    Thierry Roisnel

    2013-12-01

    Full Text Available The structure of the title polymeric compound, [Cd(SCN2(C6H8N22]n, exhibits a two-dimensional staircase-like structure parallel to (010 in which the CdII atom lies on a twofold rotation axis and has a distorted octahedral CdS2N4 geometry involving four μ-1,3-(SCN group donors and two N-atom donors from 1,3-phenylenediamine ligands, which also have twofold symmetry. The major contributions to the cohesion and the stability of this two-dimensional polymeric structure are the covalent Cd—S,N bonds and one weak intralayer N—H...S hydrogen bond.

  17. Expressões teóricas dos processos de libertação: novos paradigmas http://dx.doi.org/10.15601/1983-7631/rt.v6n11p213-228

    Directory of Open Access Journals (Sweden)

    Manuel Alfonso Díaz Muñoz

    2013-11-01

    Full Text Available O objeto deste artigo é descrever os eixos comuns às três expressões teóricas dos processos de libertação e apontar os novos paradigmas propostos perante os desafios que a contemporaneidade apresenta com a ajuda dos autores mais representativos de cada área: na teologia, Gustavo Gutiérrez; na filosofia, Enrique Dussel; na pedagogia, Paulo Freire. A análise dos novos paradigmas é feita a partir de James Cone (raça e cultura, Wanda Deifelt (gênero, Leonardo Boff (ecologia, Hans Küng (diálogo e paz e Sturla Stalsett (globalização. O resultado é um artigo que pretende fundamentar os pressupostos de uma reflexão teológica/pedagógica libertadora contemporânea.

  18. Blind pre-analysis of the main building complex WWER-440/213 Paks for comparison of analytical and experimental results obtained by explosive testing (task 7a of workplan 95/96)

    International Nuclear Information System (INIS)

    Within the research programme on Benchmark studies of seismic analysis of WWER type reactors the blind pre-analysis must be prepared for the main building complex of Paks NPP, based on given excitations derived from explosion tests. The aim of the investigation was to validate different idealization concepts (mathematical models for the idealization of the structures and the soil) as well as investigation procedures (time domain and frequency domain analysis) and finally the software tools by comparing dynamic properties (eigenfrequencies, eigenmodes, modal values) and structural response results (time histories and response spectra). This report contains results of the blind pre-analysis performed by using three dimensional idealization of the main building complex (reactor building, turbine house, galleries) by means of time and frequency domian calculation procedures

  19. Measurement of the resonance parameters of the chi(1)(1**3P(1)) and chi(2)(1**3P(2)) states of charmonium formed in antiproton-proton annihilations

    Energy Technology Data Exchange (ETDEWEB)

    Andreotti, M.; Bagnasco, S.; Baldini, W.; Bettoni, D.; Borreani, G.; Buzzo, A.; Calabrese, R.; Cester, R.; Cibinetto, G.; Dalpiaz, P.; Garzoglio, G.; Gollwitzer, K.E.; Graham, M.; Hu, M.; Joffe, D.; Kasper, J.; Lasio, G.; Lo Vetere, M.; Luppi, E.; Macri, M.; Mandelkern, M.; /Fermilab /INFN, Ferrara /Ferrara U. /INFN, Genoa /Genoa U. /UC, Irvine

    2005-03-01

    The authors have studied the {sup 3}P{sub J} ({chi}{sub e}) states of charmonium in formation by antiproton-proton annihilations in experiment E835 at the Fermilab Antiproton Source. The authors report new measurements of the mass, width, and B({chi}{sub cJ} {yields} {bar p}p) x {Lambda}({chi}{sub eJ} {yields} J/{psi} + anything) for the {chi}{sub c1} and {chi}{sub c2} by means of the inclusive reaction {bar p}p {yields} {chi}{sub cJ} {yields} J/{psi} + anything {yields} (e{sup +}e{sup -}) + anything. Using the subsample of events where {chi}{sub cJ} {yields} {gamma} + J/{psi} {yields} {gamma} + (e{sup +}e{sup -}) is fully reconstructed, we derive B({chi}{sub cJ} {yields} {bar p}p) x {Lambda}({chi}{sub cJ} {yields} J/{psi} + {gamma}). They summarize the results of the E760 (updated) and E835 measurements of mass, width and B({chi}{sub cJ} {yields} {bar p}p){Lambda}({chi}{sub cJ} {yields} J/{psi} + {gamma}) (J = 0,1,2) and discuss the significance of these measurements.

  20. Effects of Electromagnetic Fields on Fish and Invertebrates Task 2.1.3: Effects on Aquatic Organisms Fiscal Year 2012 Progress Report Environmental Effects of Marine and Hydrokinetic Energy

    Energy Technology Data Exchange (ETDEWEB)

    Woodruff, Dana L.; Cullinan, Valerie I.; Copping, Andrea E.; Marshall, Kathryn E.

    2013-05-20

    Energy generated by the world’s oceans and rivers offers the potential to make substantial contributions to the domestic and global renewable energy supply. However, the marine and hydrokinetic (MHK) energy industry faces challenges related to siting, permitting, construction, and operation of pilotand commercial-scale facilities. One of the challenges is to understand the potential effects to marine organisms from electromagnetic fields, which are produced as a by-product of transmitting power from offshore to onshore locations through underwater transmission cables. This report documents the progress of the third year of research (fiscal year 2012) to investigate environmental issues associated with marine and hydrokinetic energy (MHK) generation. This work was conducted by Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy’s (DOE’s) Office of Energy Efficiency and Renewable Energy (EERE) Wind and Water Technologies Office. The report addresses the effects of electromagnetic fields (EMFs) on selected marine species where significant knowledge gaps exist. The species studied this fiscal year included one fish and two crustacean species: the Atlantic halibut (Hippoglossus hippoglossus), Dungeness crab (Metacarcinus magister), and American lobster (Homarus americanus).

  1. Review of Recent Literature Relevant to the Environmental Effects of Marine and Hydrokinetic Energy Devices Task 2.1.3: Effects on Aquatic Organisms – Fiscal Year 2011 Progress Report Environmental Effects of Marine and Hydrokinetic Energy

    Energy Technology Data Exchange (ETDEWEB)

    Kropp, Roy K.

    2011-09-30

    A literature search was conducted by using the Web of Science® Databases component of the ISI Web of KnowledgeSM to identify recent articles that would be useful to help assess the potential environmental effects of renewable energy development in the ocean, with emphasis on marine mammals, seabirds, and fish. Several relatively recent general review articles that included possible effects of marine renewable energy devices on marine mammals and seabirds were examined to begin the search process (e.g., Boehlert et al. 2008; Thompson et al. 2008; Simas et al. 2009). From these articles, several general topics of potential environmental effects on marine mammals, seabirds, and fish were derived. These topics were used as the primary search factors. Searches were conducted with reference to the potential effects of offshore wind farms and MHK devices on marine mammals, seabirds, and fish. Additional sources were identified by cross-checking the Web of Science databases for articles that cited the review articles. It also became clear that often the potential effects were offered as hypotheses that often were not supported by the presentation of appropriate documentation. Therefore, the search was refined and focused on trying to obtain the necessary information to support or challenge a proposed potential effect to a specific concern. One of the expressed concerns regarding MHK devices is that placing wave parks in coastal waters could compromise the migration patterns of whales. Disruption of the annual migration of the gray whale (Eschrichtius robustus), which swims at least 30,000 km on its round trip from breeding grounds in Baja California to feeding areas in the Bering Sea, is of particular concern. Among the hypothesized effects on the migrating gray whales are increased predation risk by constricting migration corridor to between array and shore or by forcing the whales to swim into deeper waters, increased metabolic energy costs and delays in reaching the destinations, and interrupting feeding by blocking access to benthic areas under arrays. The literature search focused on identifying published studies that could provide information to evaluate these concerns. The results were developed into a case study that evaluated the potential effects of the placement of wave parks in coastal waters along the migration route of the gray whale. Wave parks and other MHK arrays may have additional effects on gray whales and other marine mammals, including entanglement in mooring lines and interference with communications among other effects, that were not included in this case study. The case study results were rewritten into a simpler form that would be suitable for placement on a web blog

  2. Investigation for determining the retention properties of rock over the ASSE II mine for dissolved radionuclides

    International Nuclear Information System (INIS)

    For a model consideration of groundwater movement and the associated transport of dissolved substance in deep groundwater, the retention properties of the ASSE II mine for radionuclides dissolved in water were determined. A series of properties of rocks were examined and described for this purpose. Apart from the chemical, mineralogical and petrophysical characteristics of the rocks, the retention was determined by 3 different methods and stated in the form of distribution coefficients for specific elements. A comparison of the results of vibration and diffusion experiments gave good agreement, while the results in through column experiments only reached the same order of magnitude after an expensive determination with the aid of a place concentration distribution. The distribution coefficients for the elements carbon, selenium, strontium, technetium, iodine, caesium, lead, radium, actinium, proto-actinium, uranium, neptunium, plutonium, americium and curium are listed and collected for model rock packages. (orig./HP)

  3. LASL experience in decontamination of the environment

    International Nuclear Information System (INIS)

    This discussion represents one part of a major effort in soil decontamination at the Los Alamos site. A contaminated industrial waste line in the Los Alamos townsite was removed, and a plutonium incineration facility, and a filter building contaminated with actinium-227 were dismantled. The former plutonium handling facility has been decontaminated, and canyons and an old firing site contaminated with strontium-90 have been surveyed

  4. Sorption studies of radioelements on geological materials

    OpenAIRE

    Berry, J. A; 油井 三和; 北村 暁

    2007-01-01

    Batch sorption experiments have been carried out to study the sorption of uranium, technetium, curium, neptunium, actinium, protactinium, polonium, americium and plutonium onto bentonite, granodiorite and tuff. Mathematical modelling using the HARPHRQ program and the HATCHES database was carried out to predict the speciation of uranium and technetium in the equilibrated seawater, and neptunium, americium and plutonium in the rock equilibrated water. Review of the literature for thermodynamic ...

  5. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  6. The discoveries of uranium 237 and symmetric fission — From the archival papers of Nishina and Kimura

    OpenAIRE

    IKEDA, Nagao

    2011-01-01

    Shortly before the Second World War time, Nishina reported on a series of prominent nuclear physical and radiochemical studies in collaboration with Kimura. They artificially produced 231Th, a member of the natural actinium series of nuclides, by bombarding thorium with fast neutrons. This resulted in the discovery of 237U, a new isotope of uranium, by bombarding uranium with fast neutrons, and confirmed that 237U disintegrates into element 93 with a mass number of 237. They also identified t...

  7. Protein (Cyanobacteria): 438681 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available 8 Synechococcus sp. JA-2-3B'a(2-13) MNDLLFEPTSERPSLAEIRRLSPAALAYLGDAIYELHVRRQRLFPPDRLERYHQQVVRRVRGSAQAKLLLALLPHLNPEEQEIVRWGRNGCGRPPRHLPLADYQNASGLETVLGYLYLANPERLRHILALTDVLAETLGEWEG ...

  8. NCBI nr-aa BLAST: CBRC-DNOV-01-2696 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-2696 ref|XP_722121.1| CTA213 antisense protein [Candida albicans SC531...4] ref|XP_721961.1| CTA213 antisense protein [Candida albicans SC5314] gb|EAL03183.1| CTA213 antisense prote...in [Candida albicans SC5314] gb|EAL03347.1| CTA213 antisense protein [Candida albicans SC5314] XP_722121.1 0.24 33% ...

  9. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    P. Bernot

    2005-07-13

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with {sup 231}Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or

  10. Genetically Low Antioxidant Protection and Risk of Cardiovascular Disease and Heart Failure in Diabetic Subjects

    DEFF Research Database (Denmark)

    Kobylecki, Camilla J; Afzal, Shoaib; Nordestgaard, Børge G

    2015-01-01

    BACKGROUND: Hyperglycemia-induced oxidative stress is one mechanism believed to underlie diabetic vascular disease. We tested the hypothesis that diabetic subjects heterozygous for extracellular superoxide dismutase (SOD3) R213G, which entails lower antioxidant capacity in tissues, have increased...... risk of cardiovascular disease and heart failure. METHODS: We used the prospective Copenhagen General Population Study and Copenhagen City Heart Study and genotyped 95,871 individuals for the rs1799895 R213G variation in the SOD3 gene, of which 4498 had diabetes. We used national hospitalization...... and death registers to assess cardiovascular disease and heart failure. FINDINGS: Out of 95,871 individuals, we identified 93,521 R213G non-carriers (213RR, 97.5%), 2336 heterozygotes (213RG, 2.4%) and 14 homozygotes (213GG, 0.01%). In diabetic subjects, the hazard ratio for cardiovascular disease in R213G...

  11. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  12. Dietary exposure to benzoates (E210-E213), parabens (E214-E219), nitrites (E249-E250), nitrates (E251-E252), BHA (E320), BHT (E321) and aspartame (E951) in children less than 3 years old in France.

    Science.gov (United States)

    Mancini, F R; Paul, D; Gauvreau, J; Volatier, J L; Vin, K; Hulin, M

    2015-01-01

    This study aimed to estimate the exposure to seven additives (benzoates, parabens, nitrites, nitrates, BHA, BHT and aspartame) in children aged less than 3 years old in France. A conservative approach, combining individual consumption data with maximum permitted levels, was carried out for all the additives. More refined estimates using occurrence data obtained from products' labels (collected by the French Observatory of Food Quality) were conducted for those additives that exceeded the acceptable daily intake (ADI). Information on additives' occurrence was obtained from the food labels. When the ADI was still exceeded, the exposure estimate was further refined using measured concentration data, if available. When using the maximum permitted level (MPL), the ADI was exceeded for benzoates (1.94 mg kg(-1) bw day(-1)), nitrites (0.09 mg kg(-1) bw day(-1)) and BHA (0.39 mg kg(-1) bw day(-1)) in 25%, 54% and 20% of the entire study population respectively. The main food contributors identified with this approach were current foods as these additives are not authorised in specific infant food: vegetable soups and broths for both benzoates and BHA, delicatessen and meat for nitrites. The exposure estimate was significantly reduced when using occurrence data, but in the upper-bound scenario the ADI was still exceeded significantly by the age group 13-36 months for benzoates (2%) and BHA (1%), and by the age group 7-12 months (16%) and 13-36 months (58%) for nitrites. Measured concentration data were available exclusively for nitrites and the results obtained using these data showed that the nitrites' intake was below the ADI for all the population considered in this study. These results suggest that refinement of exposure, based on the assessment of food levels, is needed to estimate the exposure of children to BHA and benzoates for which the risk of exceeding the ADI cannot be excluded when using occurrence data. PMID:25686474

  13. Aerial Photography and Imagery, Ortho-Corrected, This data set includes georectified, 4 -band digital orthophotos for 213.7 square miles of the Blackwater National Wildlife Refuge and Fishing Bay WMA in Dorchester County, MD., Published in 2010, 1:2400 (1in=200ft) scale, Eastern Shore Regional GIS Cooperative.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Aerial Photography and Imagery, Ortho-Corrected dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of...

  14. Dietary exposure to benzoates (E210-E213), parabens (E214-E219), nitrites (E249-E250), nitrates (E251-E252), BHA (E320), BHT (E321) and aspartame (E951) in children less than 3 years old in France.

    Science.gov (United States)

    Mancini, F R; Paul, D; Gauvreau, J; Volatier, J L; Vin, K; Hulin, M

    2015-01-01

    This study aimed to estimate the exposure to seven additives (benzoates, parabens, nitrites, nitrates, BHA, BHT and aspartame) in children aged less than 3 years old in France. A conservative approach, combining individual consumption data with maximum permitted levels, was carried out for all the additives. More refined estimates using occurrence data obtained from products' labels (collected by the French Observatory of Food Quality) were conducted for those additives that exceeded the acceptable daily intake (ADI). Information on additives' occurrence was obtained from the food labels. When the ADI was still exceeded, the exposure estimate was further refined using measured concentration data, if available. When using the maximum permitted level (MPL), the ADI was exceeded for benzoates (1.94 mg kg(-1) bw day(-1)), nitrites (0.09 mg kg(-1) bw day(-1)) and BHA (0.39 mg kg(-1) bw day(-1)) in 25%, 54% and 20% of the entire study population respectively. The main food contributors identified with this approach were current foods as these additives are not authorised in specific infant food: vegetable soups and broths for both benzoates and BHA, delicatessen and meat for nitrites. The exposure estimate was significantly reduced when using occurrence data, but in the upper-bound scenario the ADI was still exceeded significantly by the age group 13-36 months for benzoates (2%) and BHA (1%), and by the age group 7-12 months (16%) and 13-36 months (58%) for nitrites. Measured concentration data were available exclusively for nitrites and the results obtained using these data showed that the nitrites' intake was below the ADI for all the population considered in this study. These results suggest that refinement of exposure, based on the assessment of food levels, is needed to estimate the exposure of children to BHA and benzoates for which the risk of exceeding the ADI cannot be excluded when using occurrence data.

  15. Low background counting of 222Rn, 220Rn and 219Rn with electrostatic counters

    Science.gov (United States)

    Mong, Brian; EXO-200 Collaboration; nEXO Collaboration

    2014-09-01

    The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. Supported by NSERC Project Grants ``Search for Double Beta Decay with EXO.''

  16. Purification of cerium, neodymium and gadolinium for low background experiments

    Science.gov (United States)

    Boiko, R. S.; Barabash, A. S.; Belli, P.; Bernabei, R.; Cappella, F.; Cerulli, R.; Danevich, F. A.; Incicchitti, A.; Laubenstein, M.; Mokina, V. M.; Nisi, S.; Poda, D. V.; Polischuk, O. G.; Tretyak, V. I.

    2014-01-01

    Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search), 136Ce (2β+ candidate with one of the highest Q2β). The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides) was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  17. Mixed valency of the RE and Ac ions in solid states

    International Nuclear Information System (INIS)

    Full text: This review is devoted to consideration of the methods and results of the theoretical and experimental investigations of the electronic state of the rare earths and actinium ions in the separate compound. The methods of the high resolution X ray spectroscopy were used for our consideration. Energy of the X ray lines of the rare earths and actinium ions in free state and solid states was study carefully. Valency shifts of X Ray lines under change of electronic state of nf - ions in different oxide, fluoride and chloride compounds were determined for K -, L- and M - lines for these ions with accuracy near 10 -100 MeV. We studied the electronic state of nf- ions which is changed from '+2' to '+4' and determined the concentration of ions in different electronic state. Relative error for theoretical energy of the most lines for HFP - approach in comparison with experiment is less than 0.5%, and deviation for concentration is less than 5%

  18. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Directory of Open Access Journals (Sweden)

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  19. A study of uranium and thorium migration at the Koongarra uranium deposit with application to actinide transport from nuclear waste repositories

    International Nuclear Information System (INIS)

    One way to gain confidence in modelling possible radionuclide releases is to study natural systems which are similar to components of the multibarrier waste repository. Several such analogues are currently under study and these provide useful data about radionuclide behaviour in the natural environment. One such system is the Koongarra uranium deposit in the Northern Territory. In this dissertation, the migration of actinides, primarily uranium and thorium, has been studied as an analogue for the behaviour of transuranics in the far-field of a waste repository. The major findings of this study are: 1. the main process retarding uranium migration in the dispersion fan at Koongarra is sorption, which suppresses dissolved uranium concentrations well below solubility limits, with ferrihydrite being a major sorbing phase; 2. thorium is extremely immobile, with very low dissolved concentrations and corresponding high distribution ratios for 230Th. Overall, it is estimated that colloids are relatively unimportant in Koongarra groundwater. Uranium migrates mostly as dissolved species, whereas thorium and actinium are mostly adsorbed to larger, relatively immobile particles and the stationary phase. However, of the small amount of 230Th that passes through a 1μm filter, a significant proportion is associated with colloidal particles. Actinium appears to be slightly more mobile than thorium and is associated with colloids to a greater extent, although generally present in low concentrations. These results support the possibility of colloidal transport of trivalent and tetravalent actinides in the vicinity of a nuclear waste repository. 112 refs., 23 tabs., 32 figs

  20. Purification of cerium, neodymium and gadolinium for low background experiments

    Directory of Open Access Journals (Sweden)

    Boiko R.S.

    2014-01-01

    Full Text Available Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search, 136Ce (2β+ candidate with one of the highest Q2β. The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  1. Mid-section of a can-annular gas turbine engine with a radial air flow discharged from the compressor section

    Energy Technology Data Exchange (ETDEWEB)

    Little, David A.; McQuiggan, Gerard; Wasdell, David L.

    2016-10-25

    A midframe portion (213) of a gas turbine engine (210) is presented, and includes a compressor section (212) configured to discharge an air flow (211) directed in a radial direction from an outlet of the compressor section (212). Additionally, the midframe portion (213) includes a manifold (214) to directly couple the air flow (211) from the compressor section (212) outlet to an inlet of a respective combustor head (218) of the midframe portion (213).

  2. EST Table: FS745241 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS745241 E_FL_bmmt_30L24_R_0 10/09/28 90 %/213 aa ref|NP_001036841.1| Annexin IX is...oform A [Bombyx mori] dbj|BAA92809.1| annexin IX-A [Bombyx mori] 10/09/08 73 %/213 aa FBpp0280989|DpseGA1909...1|gene:ANXB9 10/09/10 61 %/213 aa gnl|Amel|GB16448-PA 10/09/10 73 %/213 aa gi|91092420|ref|XP_967931.1| PREDICTED: similar to Annexin IX CG5730-PC [Tribolium castaneum] FS780436 bmmt ...

  3. A new sisorid catfish of the genus Gagata Bleeker from India

    NARCIS (Netherlands)

    Tilak, R.

    1970-01-01

    CONTENTS Introduction .................. 207 Description................... 207 Sexual dimorphism................. 211 Relationships .................. 211 A key to the species of the allied genera, Gagata Bleeker etc....... 213 Acknowledgements................. 215 References................... 215

  4. Analysis of High-temperature Boiler Tube Failure for T91 &T22

    Institute of Scientific and Technical Information of China (English)

    SHU Guo-gang; DING Hui; ZHAO Yan-fen; XUE Fei; ZHAO Ling-song; ZHANG Lu; LIU Jiang-nan; WANG Zheng-pin

    2004-01-01

    The tube failures took place frequently in the superheater of 2x600MW units in a power plant. According to the condition of tube failures, the mechanical property and microstructure on running and failed tubes were tested and evaluated. The chemical composition and structure phase of inner oxide scale and deposit inside of the tubes were examined.The fractured surfaces of failed tube samples were observed. And the material examination was performed for original tube steels SA213-T91 and SA213-T22. The results show that raw materials of SA213-T91 and SA213-T22 tube in superheater are qualified. Besides, the characteristics of the SA213-T91 and SA213-T22 tube failure are typical short-term overheated rupture. The rupture temperature is located between two phase Ac1 ~ Ac3 of the two steels. It is recognized that putting SA213-T22 tubes in operation under the condition of long-term over heating causes the rupture of SA213-T91 and SA213-T22.

  5. DMPD: Regulation of innate immunity by suppressor of cytokine signaling (SOCS)proteins. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available oteins. Dalpke A, Heeg K, Bartz H, Baetz A. Immunobiology. 2008;213(3-4):225-35. Epub 2007 Nov 28. (.png) (....ignaling (SOCS)proteins. Authors Dalpke A, Heeg K, Bartz H, Baetz A. Publication Immunobiology. 2008;213(3-4

  6. Application of Kalman filter to short-term tide level prediction by Yen, P.-H., Jan, C.-D., Lee, Y.-P. and Lee, H.-F. (J. Waterway Port Coast. Ocean Eng. 122(5); 1996; pp 226-231: Discussion

    Digital Repository Service at National Institute of Oceanography (India)

    Mandal, S.; Chandramohan, P

    stream_size 2 stream_content_type text/plain stream_name J_Waterway_Port_Coast_Eng_124_213.pdf.txt stream_source_info J_Waterway_Port_Coast_Eng_124_213.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  7. 48 CFR 908.7107 - Alcohol.

    Science.gov (United States)

    2010-10-01

    ... agencies, are set forth in 26 CFR 213.141-213.146. Copies of excerpts from these regulations may be secured... control of a Federal agency may be obtained by following the procedure set forth in FPMR 41 CFR 101-48.1 ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Alcohol. 908.7107...

  8. Drug: D09791 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available fragile X syndrome and autism prodrug, active substance: Baclofen [DR:D00241] GABA-B receptor agonist [HSA:...D09791 Drug Arbaclofen (USAN) C10H12ClNO2 213.0557 213.6608 D09791.gif Treatment of

  9. 16 CFR 1130.1 - Purpose, scope, and effective date.

    Science.gov (United States)

    2010-01-01

    ... Safety Administration (NHTSA) at 49 CFR 571.213, or to products that comprise a travel system, and are sold with a child restraint system that is covered by the NHTSA registration program at 49 CFR 571.213... hook-on chairs; bath seats; gates and other enclosures for confining a child; play yards;...

  10. Readiness of the Mochovce NPP for unit 1 start-up with regards to meeting the requirements for increased safety

    International Nuclear Information System (INIS)

    A safety and reliability of operation of NPP type VVER 440/213, differences between Mochovce NPP and other VVER 440/213 NPPs contributing to the safety improvement, organization of the completion works of Mochovce NPP units 1 and technical condition of the installations are discussed

  11. 8 CFR 1240.49 - Ancillary matters, applications.

    Science.gov (United States)

    2010-01-01

    ... 249 of the Act. The application shall be subject to the requirements of 8 CFR parts 1240, 1245, and... the Act shall be made to the director in accordance with 8 CFR part 1216. In conjunction with any..., in accordance with the provisions of section 213A of the Act and 8 CFR part 213a. In...

  12. Experiment list: SRX211432 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 67.3,66 GSM1054753: SNT2 4hrs DMSO RapExpt Input; Saccharomyces cerevisiae; ChIP-Seq source_name=S. cerevisi...ae Snt2-13Myc strain || yeast strain=Snt2-13Myc || treatment=DMSO || hours treatment=4 || antibody=no antibo

  13. EST Table: FY000484 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY000484 bmov2f18 11/11/04 74 %/213 aa ref|XP_970542.1| PREDICTED: similar to brix ...1/11/04 74 %/213 aa gi|91090402|ref|XP_970542.1| PREDICTED: similar to brix domain-containing protein 2 [Tribolium castaneum] FS911686 bmov ...

  14. Drug: D01277 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01277 Drug Droxidopa (JP16/INN); Dops (TN) C9H11NO5 213.0637 213.1873 D01277.gif Antiparkins...onian [DS:H00057] Therapeutic category: 1169 precursor of Norepinephrine [DR:D00076] map07057 Antiparkins...d sensory organs 11 Agents affecting central nervous system 116 Antiparkinsonian

  15. 77 FR 27437 - Lightweight Thermal Paper From the People's Republic of China: Rescission of Countervailing Duty...

    Science.gov (United States)

    2012-05-10

    ... Administrative Review, 76 FR 67413 (November 1, 2011). On November 30, 2011, in accordance with 19 CFR 351.213(b... FR 82268 (December 30, 2011). Rescission of Administrative Review Pursuant to 19 CFR 351.213(d)(1... International Trade Administration Lightweight Thermal Paper From the People's Republic of China: Rescission...

  16. Drug: D05454 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05454 Drug Phenmetrazine hydrochloride (USP); Preludin (TN) C11H15NO. HCl 213.092 213.7038 D05454.gif Anore...xic Same as: C07433 CAS: 1707-14-8 PubChem: 47207123 LigandBox: D05454 NIKKAJI: J47

  17. Fast neutron spectrometry with organic scintillators applied to magnetic fusion experiments

    CERN Document Server

    Kaschuck, Y A; Trykov, L A; Semenov, V P

    2002-01-01

    Neutron spectrometry with NE213 liquid scintillators is commonly used in thermonuclear fusion experiments to measure the 2.45 and 14.1 MeV neutron flux. We present the unfolded neutron spectrum, which was accumulated during several ohmic deuterium plasma discharges in the Frascati Tokamak Upgrade using a 2''x2'' NE213 scintillator. In this paper, we review the application of organic scintillator neutron spectrometers to tokamaks, focusing in particular on the comparison between NE213 and stilbene scintillators. Various aspects of the calibration technique and neutron spectra unfolding procedure are considered in the context of their application for fusion neutron spectrometry. Testing and calibration measurements have been carried out using D-D and D-T neutron generator facilities with both NE213 and stilbene scintillators. The main result from these measurements is that stilbene scintillator has better neutron energy resolution than NE213. Our stilbene detector could be used for the determination of the ion ...

  18. Radionuclide interactions with marine sediments

    International Nuclear Information System (INIS)

    A critical review of the literature on the subject of the interactions of radionuclides with marine sediments has been carried out. On the basis of the information available, an attempt has been made to give ranges and 'best estimates' for the distribution ratios between seawater and sediments. These estimates have been based on an understanding of the sediment seawater system and the porewater chemistry and mineralogy. Field measurements, laboratory measurements and estimates based on stable-element geochemical data are all taken into account. Laboratory measurements include distribution-ratio and diffusion-coefficient determinations. The elements reviewed are carbon, chlorine, calcium, nickel, selenium, strontium, zirconium, niobium, technetium, tin, iodine, caesium, lead, radium, actinium, thorium, protactinium, uranium, neptunium, plutonium, americium and curium. (author)

  19. Proposed training program for construction personnel involved in remedial action work at sites contaminated by naturally occurring radionuclides

    International Nuclear Information System (INIS)

    Many sites used during the early days of the US atomic energy program are contaminated with radionuclides of the primordial decay chains (uranium, thorium, and actinium series). This contamination consists of residues resulting from refining and processing uranium and thorium. Preparation of these sites for release to unrestricted private use will involve the assistance of construction workers, many of whom have limited knowledge of the hazards associated with radioactive materials. Therefore, there is a need to educate these workers in the fundamentals of radioactive material handling to minimize exposures and possible spread of contamination. This training should disseminate relevant information at an appropriate educational level and should instill a cautious, common-sense attitude toward the handling of radioactive materials. The training should emphasize basic information concerning environmental radiation within a context of relative risk. A multi-media format, including colorful visual aids, demonstration, and discussion, should be used to maximize motivation and retention. A detailed, proposed training program design is presented

  20. JAEA thermodynamic database for performance assessment of geological disposal of high-level and TRU wastes. Refinement of thermodynamic data for trivalent actinoids and samarium

    International Nuclear Information System (INIS)

    Within the scope of the JAEA thermodynamic database project for performance assessment of geological disposal of high-level radioactive and TRU wastes, the refinement of the thermodynamic data for the inorganic compounds and complexes of trivalent actinoids (actinium(III), plutonium(III), americium(III) and curium(III)) and samarium(III) was carried out. Refinement of thermodynamic data for these elements was based on the thermodynamic database for americium published by the Nuclear Energy Agency in the Organisation for Economic Co-operation and Development (OECD/NEA). Based on the similarity of chemical properties among trivalent actinoids and samarium, complementary thermodynamic data for their species expected under the geological disposal conditions were selected to complete the thermodynamic data set for the performance assessment of geological disposal of radioactive wastes. (author)