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Sample records for actinium 211

  1. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  2. Separation of Actinium 227 from the uranium minerals

    International Nuclear Information System (INIS)

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  3. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  4. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  5. Spectroscopic and computational investigation of actinium coordination chemistry.

    Science.gov (United States)

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  6. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  7. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    International Nuclear Information System (INIS)

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  8. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  9. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    International Nuclear Information System (INIS)

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  10. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  11. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  12. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Science.gov (United States)

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  13. 49 CFR 211.75 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Evidence. 211.75 Section 211.75 Transportation... TRANSPORTATION RULES OF PRACTICE Interim Procedures for the Review of Emergency Orders § 211.75 Evidence. (a) The Federal Rules of Evidence for United States Courts and Magistrates shall be employed as general...

  14. 49 CFR 399.211 - Maintenance.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Maintenance. 399.211 Section 399.211 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY... STANDARDS Step, Handhold, and Deck Requirements for Commercial Motor Vehicles § 399.211 Maintenance....

  15. 12 CFR 741.211 - Advertising.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Advertising. 741.211 Section 741.211 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS REQUIREMENTS FOR... Also Apply to Federally Insured State-Chartered Credit Unions § 741.211 Advertising. Any credit...

  16. 33 CFR 117.211 - Mystic River.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Mystic River. 117.211 Section 117.211 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.211 Mystic River. (a) The draw of the...

  17. 8 CFR 211.5 - Alien commuters.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Alien commuters. 211.5 Section 211.5 Aliens...: IMMIGRANTS; WAIVERS § 211.5 Alien commuters. (a) General. An alien lawfully admitted for permanent residence.... An alien commuter engaged in seasonal work will be presumed to have taken up residence in the...

  18. 22 CFR 21.1 - Policy.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Policy. 21.1 Section 21.1 Foreign Relations DEPARTMENT OF STATE PERSONNEL INDEMNIFICATION OF EMPLOYEES § 21.1 Policy. (a) The Department of State may indemnify an employee for any verdict, judgment, or other monetary award which is rendered against...

  19. 12 CFR 211.42 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Definitions. 211.42 Section 211.42 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Lending Supervision § 211.42 Definitions. For the purposes of...

  20. 5 CFR 211.101 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Purpose. 211.101 Section 211.101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS VETERAN PREFERENCE § 211.101 Purpose. The purpose of this part is to define veterans' preference and the administration of...

  1. 40 CFR 21.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Scope. 21.1 Section 21.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SMALL BUSINESS § 21.1 Scope. This part establishes procedures for the issuance by EPA of the statements, referred to in section 7(g) of the Small Business...

  2. 25 CFR 211.20 - Leasing procedures.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Leasing procedures. 211.20 Section 211.20 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF TRIBAL LANDS FOR MINERAL DEVELOPMENT How To Acquire Leases § 211.20 Leasing procedures. (a) Indian mineral owners may, with...

  3. 47 CFR 53.211 - Audit planning.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Audit planning. 53.211 Section 53.211 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) SPECIAL PROVISIONS CONCERNING BELL OPERATING COMPANIES Separate Affiliate; Safeguards § 53.211 Audit planning....

  4. 7 CFR 3565.211 - Interest credit.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Interest credit. 3565.211 Section 3565.211... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Loan Requirements § 3565.211 Interest credit. (a... assistance in the form of interest credit, to the extent necessary to reduce the agreed-upon rate of...

  5. 14 CFR 417.211 - Debris analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Debris analysis. 417.211 Section 417.211... TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.211 Debris analysis. (a) General. A flight safety analysis must include a debris analysis. For an orbital or suborbital launch, a debris...

  6. 5 CFR 353.211 - Appeal rights.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Appeal rights. 353.211 Section 353.211... UNIFORMED SERVICE OR COMPENSABLE INJURY Uniformed Service § 353.211 Appeal rights. An individual who... pursue to the case. However, National Guard technicians do not have the right to appeal to MSPB a...

  7. 21 CFR 211.137 - Expiration dating.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Expiration dating. 211.137 Section 211.137 Food... § 211.137 Expiration dating. (a) To assure that a drug product meets applicable standards of identity, strength, quality, and purity at the time of use, it shall bear an expiration date determined...

  8. 21 CFR 211.56 - Sanitation.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Sanitation. 211.56 Section 211.56 Food and Drugs... Sanitation. (a) Any building used in the manufacture, processing, packing, or holding of a drug product shall... assigning responsibility for sanitation and describing in sufficient detail the cleaning schedules,...

  9. 21 CFR 211.58 - Maintenance.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Maintenance. 211.58 Section 211.58 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL... Maintenance. Any building used in the manufacture, processing, packing, or holding of a drug product shall...

  10. 27 CFR 24.211 - Formula required.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Formula required. 24.211... OF THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.211 Formula required. The proprietor who desires to produce wine other than standard wine shall first obtain approval of the formula...

  11. 21 CFR 211.176 - Penicillin contamination.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Penicillin contamination. 211.176 Section 211.176... Penicillin contamination. If a reasonable possibility exists that a non-penicillin drug product has been exposed to cross-contamination with penicillin, the non-penicillin drug product shall be tested for...

  12. 14 CFR 91.211 - Supplemental oxygen.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Supplemental oxygen. 91.211 Section 91.211 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC...) At flight altitudes above flight level 250 unless at least a 10-minute supply of supplemental...

  13. 38 CFR 3.211 - Death.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Death. 3.211 Section 3..., Compensation, and Dependency and Indemnity Compensation Evidence Requirements § 3.211 Death. Death should be... community where death occurred. (2) A copy of a coroner's report of death or a verdict of a coroner's...

  14. 33 CFR 136.211 - Compensation allowable.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Compensation allowable. 136.211...) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; CLAIMS PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.211...

  15. 47 CFR 1.211 - Service.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Service. 1.211 Section 1.211 Telecommunication... Service. Except as otherwise expressly provided in this chapter, all pleadings filed in a hearing... counsel, then upon such party. All such papers shall be accompanied by proof of service. For...

  16. 31 CFR 800.211 - Entity.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity. 800.211 Section 800.211 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... separate legal entity) operated by any one of the foregoing as a business undertaking in a...

  17. 21 CFR 211.173 - Laboratory animals.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory animals. 211.173 Section 211.173 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... Laboratory animals. Animals used in testing components, in-process materials, or drug products for...

  18. 49 CFR 1542.211 - Identification systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Identification systems. 1542.211 Section 1542.211... systems. (a) Personnel identification system. The personnel identification system under §§ 1542.201(b)(3... identification media stock and supplies. (iv) Auditing the system at a minimum of once a year or sooner,...

  19. 29 CFR 1952.211 - Developmental schedule.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Developmental schedule. 1952.211 Section 1952.211 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... schedule. (a) Occupational health study accepted and implementation begun July, 1973; (b) Compliance...

  20. 21 CFR 211.65 - Equipment construction.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment construction. 211.65 Section 211.65 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... construction. (a) Equipment shall be constructed so that surfaces that contact components, in-process...

  1. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  2. 48 CFR 211.272 - Alternate preservation, packaging, and packing.

    Science.gov (United States)

    2010-10-01

    ..., packaging, and packing. 211.272 Section 211.272 Federal Acquisition Regulations System DEFENSE ACQUISITION... Requirements Documents 211.272 Alternate preservation, packaging, and packing. Use the provision at 252.211-7004, Alternate Preservation, Packaging, and Packing, in solicitations which include...

  3. 48 CFR 252.211-7003 - Item identification and valuation.

    Science.gov (United States)

    2010-10-01

    ... valuation. 252.211-7003 Section 252.211-7003 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.211-7003 Item identification and valuation. As prescribed in 211.274-6(a), use the following clause: Item Identification and Valuation (AUG 2008) (a) Definitions. As...

  4. 7 CFR 62.211 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURAL COMMODITIES (QUALITY SYSTEMS VERIFICATION PROGRAMS) Quality Systems Verification Programs Definitions Service § 62.211 Appeals. Appeals of adverse decisions under this part, may be made in writing to... of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards,...

  5. 40 CFR 98.211 - Reporting threshold.

    Science.gov (United States)

    2010-07-01

    ...) MANDATORY GREENHOUSE GAS REPORTING Miscellaneous Uses of Carbonate § 98.211 Reporting threshold. You must report GHG emissions from miscellaneous uses of carbonate if your facility uses carbonates as defined...

  6. 29 CFR 1603.211 - Subpoenas.

    Science.gov (United States)

    2010-07-01

    ... STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.211 Subpoenas. (a) Upon written application of any... with 29 CFR 1601.16(c)....

  7. 32 CFR 552.211 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... Installation of Aberdeen Proving Ground, Maryland § 552.211 Purpose. This subpart establishes policies, responsibilities, and procedures for protests, pickeing, and other similar demonstrations on the Aberdeen Proving Ground installation....

  8. CYFRA 21-1: AN OVERVIEW

    OpenAIRE

    Soma Susan Varghese; Madhavan Nirmal; Sunil, P. M.; Jithin Jose

    2013-01-01

    Cytokeratins are group of intermediate filament proteins and based on thetissue expression, cytokeratins are classified into simple epithelial cytokeratin andstratified epithelial cytokeratins. CK expression pattern in the malignant cells areusually retained from the cell of origin, and therefore CK are being used in tumortyping. Cyfra 21-1 is a soluble fragment of cytokeratin 19 is an acid type cytokeratin,with a molecular weight of 40,000d. The assumption is that Cyfra 21-1 is released into...

  9. New method for large scale production of medically applicable Actinium-225 and Radium-223

    International Nuclear Information System (INIS)

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  10. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    International Nuclear Information System (INIS)

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  11. CYFRA 21-1: AN OVERVIEW

    Directory of Open Access Journals (Sweden)

    Soma Susan Varghese

    2013-07-01

    Full Text Available Cytokeratins are group of intermediate filament proteins and based on thetissue expression, cytokeratins are classified into simple epithelial cytokeratin andstratified epithelial cytokeratins. CK expression pattern in the malignant cells areusually retained from the cell of origin, and therefore CK are being used in tumortyping. Cyfra 21-1 is a soluble fragment of cytokeratin 19 is an acid type cytokeratin,with a molecular weight of 40,000d. The assumption is that Cyfra 21-1 is released intothe bloodstream during cell death, and therefore its level correlates very well with thetumour mass, or more specifically with the necrosis in the tumour, which is a functionof the tumour mass. The aim of this article is to review on cyfra 21-1 and its role as adiagnostic and prognostic marker.

  12. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  13. 34 CFR 682.211 - Forbearance.

    Science.gov (United States)

    2010-07-01

    ... endorser in order to prevent the borrower or endorser from defaulting on the borrower's or endorser's... § 682.402(b)(3). (Approved by the Office of Management and Budget under control number 1845-0020... citations affecting § 682.211, see the List of CFR Sections Affected, which appears in the Finding...

  14. 29 CFR 2.11 - General principles.

    Science.gov (United States)

    2010-07-01

    ... Secretary of Labor GENERAL REGULATIONS Audiovisual Coverage of Administrative Hearings § 2.11 General... involve administrative hearings. If such administrative hearings are held, we encourage their audiovisual coverage. (b) Audiovisual coverage shall be excluded in adjudicatory proceedings involving the rights...

  15. 45 CFR 211.15 - Nondiscrimination.

    Science.gov (United States)

    2010-10-01

    ... of any benefits, under the Act. (b) The prohibition in paragraph (a) of this section precludes... ILL NATIONALS OF THE UNITED STATES, RETURNED FROM FOREIGN COUNTRIES § 211.15 Nondiscrimination. (a) No eligible person shall, on the ground of race, color, or national origin, be excluded from participation,...

  16. 14 CFR 67.211 - Cardiovascular.

    Science.gov (United States)

    2010-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN MEDICAL STANDARDS AND CERTIFICATION Second-Class Airman Medical Certificate § 67.211 Cardiovascular. Cardiovascular standards for a second-class medical certificate are no established medical history or clinical diagnosis...

  17. 24 CFR 880.211 - Audit.

    Science.gov (United States)

    2010-04-01

    ... administrator under § 880.505 receiving financial assistance under this part, the audit requirements in 24 CFR... financial assistance under this part, the audit requirements in 24 CFR part 45 shall apply. ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 880.211 Section...

  18. 24 CFR 881.211 - Audit.

    Science.gov (United States)

    2010-04-01

    ... requirements in 24 CFR part 44 shall apply. (b) Where a nonprofit organization is the eligible owner of a project, receiving financial assistance under this part, the audit requirements in 24 CFR part 45 shall... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Audit. 881.211 Section...

  19. 46 CFR 169.211 - Permit to proceed for repair.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Permit to proceed for repair. 169.211 Section 169.211... Inspection and Certification Certificate of Inspection § 169.211 Permit to proceed for repair. (a) The Officer in Charge, Marine Inspection, may issue a permit to proceed to another port for repair, Form...

  20. 21 CFR 211.52 - Washing and toilet facilities.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Washing and toilet facilities. 211.52 Section 211.52 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... § 211.52 Washing and toilet facilities. Adequate washing facilities shall be provided, including hot...

  1. 9 CFR 113.211 - Feline Rhinotracheitis Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... Virus. 113.211 Section 113.211 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.211 Feline Rhinotracheitis Vaccine, Killed Virus....

  2. 40 CFR 211.212 - Compliance audit testing.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Compliance audit testing. 211.212 Section 211.212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE LABELING Hearing Protective Devices § 211.212 Compliance audit testing....

  3. 21 CFR 211.103 - Calculation of yield.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Calculation of yield. 211.103 Section 211.103 Food... § 211.103 Calculation of yield. Actual yields and percentages of theoretical yield shall be determined... the drug product. Such calculations shall either be performed by one person and independently...

  4. 5 CFR 179.211 - Notice of salary offset.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Notice of salary offset. 179.211 Section 179.211 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.211 Notice of salary offset. (a) Upon receipt of...

  5. 48 CFR 852.211-70 - Service data manuals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Service data manuals. 852.211-70 Section 852.211-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 852.211-70 Service data manuals. (a) As prescribed...

  6. 42 CFR 59.211 - Publications and copyright.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Publications and copyright. 59.211 Section 59.211... PLANNING SERVICES Grants for Family Planning Service Training § 59.211 Publications and copyright. Except as may otherwise be provided under the terms and conditions of the award, the grantee may...

  7. 34 CFR 300.211 - Information for SEA.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Information for SEA. 300.211 Section 300.211 Education... DISABILITIES Local Educational Agency Eligibility § 300.211 Information for SEA. The LEA must provide the SEA with information necessary to enable the SEA to carry out its duties under Part B of the Act,...

  8. 20 CFR 211.13 - Payments made after death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Payments made after death. 211.13 Section 211... CREDITABLE RAILROAD COMPENSATION § 211.13 Payments made after death. Payments made by an employer with respect to a deceased employee but paid after the calendar year of the employee's death to the...

  9. 20 CFR 211.2 - Definition of compensation.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Definition of compensation. 211.2 Section 211... CREDITABLE RAILROAD COMPENSATION § 211.2 Definition of compensation. (a) The term compensation means any form... termination allowance paid under section 702 of that Act. Compensation may be paid as money, a commodity,...

  10. 40 CFR 211.103 - Number and gender.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Number and gender. 211.103 Section 211... PRODUCT NOISE LABELING General Provisions § 211.103 Number and gender. In this part, words in the singular will be understood to include the plural, and words in the masculine gender will be understood...

  11. 5 CFR 930.211 - Actions against administrative law judges.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Actions against administrative law judges. 930.211 Section 930.211 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL...) Administrative Law Judge Program § 930.211 Actions against administrative law judges. (a) Procedures. An...

  12. 48 CFR 211.274-3 - Policy for valuation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Policy for valuation. 211.274-3 Section 211.274-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Documents 211.274-3 Policy for valuation. (a) It is DoD policy that contractors shall be required...

  13. 48 CFR 211.274 - Item identification and valuation requirements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Item identification and valuation requirements. 211.274 Section 211.274 Federal Acquisition Regulations System DEFENSE ACQUISITION... Requirements Documents 211.274 Item identification and valuation requirements....

  14. 40 CFR 211.206-1 - Real ear method.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Real ear method. 211.206-1 Section 211... PRODUCT NOISE LABELING Hearing Protective Devices § 211.206-1 Real ear method. (a) The value of sound... “Method for the Measurement of Real-Ear Protection of Hearing Protectors and Physical Attenuation...

  15. Building 211 cyclotron characterization survey report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-30

    The Building 211 Cyclotron Characterization Survey includes an assessment of the radioactive and chemical inventory of materials stored within the facility; an evaluation of the relative distribution of accelerator-produced activation products within various cyclotron components and adjacent structures; measurement of the radiation fields throughout the facility; measurement and assessment of internal and external radioactive surface contamination on various equipment, facility structures, and air-handling systems; and an assessment of lead (Pb) paint and asbestos hazards within the facility.

  16. H2 Velocity Structure in HH 211

    OpenAIRE

    Salas, L.; I. Cruz González; Margarita Rosado

    2003-01-01

    Describimos la estructura en velocidad del chorro molecular HH211 en la línea 2.12 Um del H2. Las observaciones fueron obtenidas con un interferómetro Fabry-Pérot con resolución espectral de 24 km s_1. Se pudo observar que el lóbulo este del chorro está corrido al azul mientras que el del oeste está corrido al rojo. La mayor parte de la radiación se origina en bajas velocidades, en concordancia con la relación flujo-velocidad de Salas & Cruz-González (2002), pero estas bajas ...

  17. 40 CFR 211.111 - Testing by the Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing by the Administrator. 211.111... PROGRAMS PRODUCT NOISE LABELING General Provisions § 211.111 Testing by the Administrator. (a)(1) To determine whether products conform to applicable regulations under this part, the Administrator may...

  18. 49 CFR 211.77 - Appeal to the Administrator.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Appeal to the Administrator. 211.77 Section 211.77... Appeal to the Administrator. (a) Any party aggrieved by the final decision of a presiding officer (other than the Administrator) may appeal to the Administrator. The appeal must be filed within twenty...

  19. 21 CFR 211.130 - Packaging and labeling operations.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Packaging and labeling operations. 211.130 Section... (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Packaging and Labeling Control § 211.130 Packaging and labeling operations. There shall be written procedures designed...

  20. 7 CFR 58.211 - Packaging room for bulk products.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Packaging room for bulk products. 58.211 Section 58... Service 1 Rooms and Compartments § 58.211 Packaging room for bulk products. A separate room or area shall... dust within the packaging room and where needed, a dust collector shall be provided and...

  1. 27 CFR 555.211 - Construction of type 5 magazines.

    Science.gov (United States)

    2010-04-01

    .... (5) Placards. The placards required by Department of Transportation regulations at 49 CFR part 172... magazines. 555.211 Section 555.211 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO... Construction of type 5 magazines. A type 5 magazine is a building, igloo or “Army-type structure”,...

  2. 48 CFR 552.211-87 - Export packing.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Export packing. 552.211-87... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.211-87 Export packing. As prescribed in 511.204(b)(7), insert the following clause: Export Packing (JAN 2010)...

  3. 17 CFR 256.211 - Miscellaneous paid-in capital.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Miscellaneous paid-in capital. 256.211 Section 256.211 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... capital. This account shall include the balance of all other credits for paid-in capital which are...

  4. 21 CFR 211.182 - Equipment cleaning and use log.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Equipment cleaning and use log. 211.182 Section... Reports § 211.182 Equipment cleaning and use log. A written record of major equipment cleaning... individual equipment logs that show the date, time, product, and lot number of each batch processed....

  5. 21 CFR 211.113 - Control of microbiological contamination.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Control of microbiological contamination. 211.113... Process Controls § 211.113 Control of microbiological contamination. (a) Appropriate written procedures... contamination of drug products purporting to be sterile, shall be established and followed. Such...

  6. 49 CFR 1546.211 - Law enforcement personnel.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Law enforcement personnel. 1546.211 Section 1546... § 1546.211 Law enforcement personnel. (a) At airports within the United States not governed by part 1542...) When using a screening system required by § 1546.101(a), (b), or (c), provide for law...

  7. 48 CFR 1552.211-74 - Work assignments.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Work assignments. 1552.211-74 Section 1552.211-74 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CLAUSES... not allow for any change to the terms or conditions of the contract. Where any language in the...

  8. 20 CFR 655.211 - Petition for higher meal charges.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Petition for higher meal charges. 655.211...-H-2A Agricultural Employment § 655.211 Petition for higher meal charges. (a) Until a new amount is... to $6.17 for providing them with three meals per day, if the employer justifies the charge...

  9. 33 CFR 211.22 - Real estate Claims Officers.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Real estate Claims Officers. 211..., DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real Estate Claims § 211.22 Real estate Claims Officers. In each Division Office the...

  10. 33 CFR 211.1 - Real estate defined.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Real estate defined. 211.1... DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real Estate; General § 211.1 Real estate defined. The term real estate as used in this part includes...

  11. 12 CFR 211.11 - Advisory opinions under Regulation K.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Advisory opinions under Regulation K. 211.11... INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Operations of U.S. Banking Organizations § 211.11 Advisory opinions under Regulation K. (a) Request for advisory opinion. Any person may submit a request...

  12. 22 CFR 211.5 - Obligations of cooperating sponsor.

    Science.gov (United States)

    2010-04-01

    ... of approved programs; (ii) Implement income generating, community development, health, nutrition... Section 211.5 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TRANSFER OF FOOD COMMODITIES FOR FOOD USE IN DISASTER RELIEF, ECONOMIC DEVELOPMENT AND OTHER ASSISTANCE § 211.5 Obligations of...

  13. 7 CFR 1220.211 - Powers of the Board.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Powers of the Board. 1220.211 Section 1220.211 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... the Federal Reserve System, or in obligations fully guaranteed as to principal and interest by...

  14. 20 CFR 211.15 - Verification of compensation claimed.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Verification of compensation claimed. 211.15... CREDITABLE RAILROAD COMPENSATION § 211.15 Verification of compensation claimed. Compensation claimed by an... Board before it may be credited. An employee's claim to compensation not credited shall be processed...

  15. 20 CFR 211.14 - Maximum creditable compensation.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Maximum creditable compensation. 211.14... CREDITABLE RAILROAD COMPENSATION § 211.14 Maximum creditable compensation. Maximum creditable compensation... Employment Accounts shall notify each employer of the amount of maximum creditable compensation applicable...

  16. 20 CFR 211.5 - Employee representative compensation.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Employee representative compensation. 211.5... CREDITABLE RAILROAD COMPENSATION § 211.5 Employee representative compensation. All payments made by a railway... office he occupies with such organization are creditable as compensation, including payments made...

  17. 14 CFR 221.211 - Cancellation of suspended matter.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Cancellation of suspended matter. 221.211 Section 221.211 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION... matter. When, pursuant to an order of the Department, the cancellation of rules, fares, charges, or...

  18. 22 CFR 211.4 - Availability and shipment of commodities.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Availability and shipment of commodities. 211.4 Section 211.4 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TRANSFER OF FOOD COMMODITIES FOR FOOD... commodities. (a) Shipment, distribution and use of commodities. Commodities shall be available for...

  19. 14 CFR 171.211 - Maintenance and operations requirements.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Maintenance and operations requirements. 171.211 Section 171.211 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES VHF Marker Beacons §...

  20. 47 CFR 97.211 - Space telecommand station.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Space telecommand station. 97.211 Section 97... AMATEUR RADIO SERVICE Special Operations § 97.211 Space telecommand station. (a) Any amateur station designated by the licensee of a space station is eligible to transmit as a telecommand station for that...

  1. 49 CFR 219.211 - Analysis and follow-up.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Analysis and follow-up. 219.211 Section 219.211 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Analysis and follow-up. (a) The laboratory designated in appendix B to this part undertakes prompt...

  2. 29 CFR 553.211 - Law enforcement activities.

    Science.gov (United States)

    2010-07-01

    ... includes physical training, self-defense, firearm proficiency, criminal and civil law principles... they are elected officials and if they are not subject to the civil service laws of their particular... 29 Labor 3 2010-07-01 2010-07-01 false Law enforcement activities. 553.211 Section 553.211...

  3. 22 CFR 211.6 - Processing, repackaging, and labeling commodities.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Processing, repackaging, and labeling commodities. 211.6 Section 211.6 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT TRANSFER OF FOOD... containers as provided in paragraph (c) of this section, and banners, posters, or similar media which...

  4. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  5. Comparison of (211)At-PRIT and (211)At-RIT of Ovarian Microtumors in a Nude Mouse Model

    DEFF Research Database (Denmark)

    Frost, Sofia H L; Bäck, Tom; Chouin, Nicolas;

    2013-01-01

    Abstract Purpose: Pretargeted radioimmunotherapy (PRIT) against intraperitoneal (i.p.) ovarian microtumors using avidin-conjugated monoclonal antibody MX35 (avidin-MX35) and (211)At-labeled, biotinylated, succinylated poly-l-lysine ((211)At-B-PL(suc)) was compared with conventional radioimmunothe......Abstract Purpose: Pretargeted radioimmunotherapy (PRIT) against intraperitoneal (i.p.) ovarian microtumors using avidin-conjugated monoclonal antibody MX35 (avidin-MX35) and (211)At-labeled, biotinylated, succinylated poly-l-lysine ((211)At-B-PL(suc)) was compared with conventional...... radioimmunotherapy (RIT) using (211)At-labeled MX35 in a nude mouse model. Methods: Mice were inoculated i.p. with 1×10(7) NIH:OVCAR-3 cells. After 3 weeks, they received PRIT (1.0 or 1.5 MBq), RIT (0.9 MBq), or no treatment. Concurrently, 10 additional animals were sacrificed and examined to determine disease...

  6. 48 CFR 252.211-7004 - Alternate preservation, packaging, and packing.

    Science.gov (United States)

    2010-10-01

    ..., packaging, and packing. 252.211-7004 Section 252.211-7004 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.211-7004 Alternate preservation, packaging, and packing. As prescribed in 211.272, use the following provision: Alternate Preservation, Packaging, and Packing (DEC...

  7. 33 CFR 211.24 - Disposition of claims.

    Science.gov (United States)

    2010-07-01

    ... Section 211.24 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real... damages not exceeding $1,000 may be settled by the Division Engineer. If the Division Engineer allows...

  8. 27 CFR 25.211 - Beer returned to brewery.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Beer returned to brewery..., DEPARTMENT OF THE TREASURY LIQUORS BEER Beer Returned to Brewery § 25.211 Beer returned to brewery. (a) General. Beer, produced in the United States, on which the brewer has paid or determined the tax may...

  9. 48 CFR 552.211-75 - Preservation, Packaging and Packing.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Preservation, Packaging....211-75 Preservation, Packaging and Packing. As prescribed in 511.204(b)(2), insert the following clause: Preservation, Packaging, and Packing (FEB 1996) Unless otherwise specified, all items shall...

  10. 30 CFR 250.211 - What must the EP include?

    Science.gov (United States)

    2010-07-01

    ... exploration drilling, well test flaring, installing a well protection structure, and temporary well abandonment. (b) Location. A map showing the surface location and water depth of each proposed well and the....211 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS...

  11. 33 CFR 211.2 - Authority to acquire real estate.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Authority to acquire real estate..., DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Real Estate; General § 211.2 Authority to acquire real estate. (a) Congressional...

  12. 48 CFR 752.211-70 - Language and measurement.

    Science.gov (United States)

    2010-10-01

    ....211-70 Language and measurement. The following clause shall be used in all USAID-direct contracts. Language and Measurement (JUN 1992) (a) The English language shall be used in all written communications... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Language and...

  13. 48 CFR 52.211-18 - Variation in Estimated Quantity.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Variation in Estimated....211-18 Variation in Estimated Quantity. As prescribed in 11.703(c), insert the following clause in... in the estimated quantity of unit-priced items: Variation in Estimated Quantity (APR 1984) If...

  14. 211Po - Comments on Evaluation of Decay Data

    International Nuclear Information System (INIS)

    This evaluation was completed in August 2009. The literature available by December 31st, 2008 was included. Evaluation Procedures: The Limitation of Relative Statistical Weight (LWM) method was applied for averaging numbers throughout this evaluation; this method was implemented by using the computer code LWEIGHT, ver. 4 (designed for Excel, MS Office). The uncertainty assigned to an average value in this evaluation is never lower than the lowest uncertainty of any of the experimental input values. Decay Scheme; 211Po decays 100% by alpha particle emissions, mainly to the ground state of 207Pb. The most recent evaluations of the 211Po nuclear structure and decay data, published in Nuclear Data Sheets, were done by E. Browne (2004) and M.J. Martin (1993). In the present evaluation, the spin, parity and energy of the levels, together with the multipolarities and mixing ratios of the γ-ray transitions, have been adopted from the A=207 ENSDF mass-chain evaluation 1993Ma73.This data evaluation refers only to the decay of the 211Po ground state, and not to the decay of the 211Po metastable state at 1462 keV (with a half-life of 25.2 s)

  15. 48 CFR 1852.211-70 - Packaging, handling, and transportation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Packaging, handling, and... and Clauses 1852.211-70 Packaging, handling, and transportation. As prescribed in 1811.404-70, insert the following clause: Packaging, Handling, and Transportation (SEPT 2005) (a) The Contractor...

  16. 31 CFR 31.211 - Organizational conflicts of interest.

    Science.gov (United States)

    2010-07-01

    ... conflicts of interest. (3) Terminating or refraining from business relationships that give rise to conflicts... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Organizational conflicts of interest... ASSET RELIEF PROGRAM Conflicts of Interest § 31.211 Organizational conflicts of interest. (a)...

  17. 48 CFR 1552.211-76 - Legal analysis.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Legal analysis. 1552.211-76... analysis. As prescribed in 1511.011-76, insert this contract clause when it is determined that the contract involves legal analysis. Legal Analysis (APR 1984) The Contractor shall furnish to the Project Officer...

  18. 40 CFR 86.211-94 - Exhaust gas analytical system.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Exhaust gas analytical system. 86.211... analytical system. The provisions of § 86.111-94 apply to this subpart, except that the NOX analyzer is optional. The exhaust gas analytical system must contain components necessary to determine...

  19. 31 CFR 538.211 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 538... § 538.211 Evasions; attempts; conspiracies. Any transaction by any United States person or within the..., any of the prohibitions set forth in this part is prohibited. Any conspiracy formed for the purpose...

  20. 31 CFR 575.211 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 575... § 575.211 Evasions; attempts; conspiracies. Any transaction for the purpose of, or which has the effect... this part is hereby prohibited. Any conspiracy formed for the purpose of engaging in a...

  1. 22 CFR 211.1 - General purpose and scope; legislation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false General purpose and scope; legislation. 211.1...; legislation. (a) Legislation. The Agricultural Trade Development and Assistance Act of 1954, as amended (Pub...-624, 104 Stat. 3632-65 (1990). The legislation implemented by the regulation in this part (as of...

  2. 27 CFR 26.211 - Warehouse receipts covering distilled spirits.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Warehouse receipts... and Recordkeeping § 26.211 Warehouse receipts covering distilled spirits. The sale of warehouse..., warehouse receipts for distilled spirits stored in warehouses, or elsewhere, must register and keep...

  3. 12 CFR 211.43 - Allocated transfer risk reserve.

    Science.gov (United States)

    2010-01-01

    ... actions taken to restore debt service capability; (3) Prospects for restored asset quality; and (4) Such other factors as the Federal banking agencies may consider relevant to the quality of the asset. (B) The... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Allocated transfer risk reserve. 211.43...

  4. 24 CFR 3286. 211 - Expiration and renewal of installation licenses.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Expiration and renewal of... Licensing in HUD-Administered States § 3286. 211 Expiration and renewal of installation licenses. (a) Expiration. Each installation license issued or renewed under this subpart C will expire 3 years after...

  5. 22 CFR 1203.735-211 - Activities relating to private organizations and politics.

    Science.gov (United States)

    2010-04-01

    ... politics. 1203.735-211 Section 1203.735-211 Foreign Relations UNITED STATES INTERNATIONAL DEVELOPMENT... Employees § 1203.735-211 Activities relating to private organizations and politics. (a) Definition. For the... engage in any form of political activity in any foreign country. (h) Activities relating to U.S....

  6. 40 CFR Appendix A to Part 211 - Compliance Audit Testing Report

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Compliance Audit Testing Report A... ABATEMENT PROGRAMS PRODUCT NOISE LABELING Pt. 211, App. A Appendix A to Part 211—Compliance Audit Testing... conformance with applicable regulations under 40 CFR Part 211, et seq. All the data reported here are true...

  7. 33 CFR 211.78 - Maintenance and conveyance of access roads.

    Science.gov (United States)

    2010-07-01

    ... Site Development and Use § 211.78 Maintenance and conveyance of access roads. The Government will not... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Maintenance and conveyance of access roads. 211.78 Section 211.78 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF...

  8. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  9. 14 CFR 302.211 - Procedures in certificate cases involving initial or continuing fitness.

    Science.gov (United States)

    2010-01-01

    ... initial or continuing fitness. 302.211 Section 302.211 Aeronautics and Space OFFICE OF THE SECRETARY... Disposition of Applications § 302.211 Procedures in certificate cases involving initial or continuing fitness... applicant's fitness to operate. Where such applications propose the operation of scheduled service...

  10. 48 CFR 552.211-89 - Non-manufactured wood packaging material for export.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Non-manufactured wood packaging material for export. 552.211-89 Section 552.211-89 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.211-89...

  11. 48 CFR 1552.211-80 - Data standards for the transmission of laboratory measurement results.

    Science.gov (United States)

    2010-10-01

    ... Texts of Provisions and Clauses 1552.211-80 Data standards for the transmission of laboratory... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Data standards for the transmission of laboratory measurement results. 1552.211-80 Section 1552.211-80 Federal Acquisition...

  12. 48 CFR 552.211-86 - Maximum weight per shipping container.

    Science.gov (United States)

    2010-10-01

    ... shipping container. 552.211-86 Section 552.211-86 Federal Acquisition Regulations System GENERAL SERVICES....211-86 Maximum weight per shipping container. As prescribed in 511.204(b)(6), insert the following clause: Maximum Weight per Shipping Container (JAN 2010) In no instance shall the weight of a...

  13. 46 CFR 14.211 - Posting of copy of shipping articles.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Posting of copy of shipping articles. 14.211 Section 14.211 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN SHIPMENT AND DISCHARGE OF MERCHANT MARINERS Shipment of Merchant Mariners § 14.211 Posting of copy of...

  14. 37 CFR 211.6 - Methods of affixation and placement of mask work notice.

    Science.gov (United States)

    2010-07-01

    ... placement of mask work notice. 211.6 Section 211.6 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES MASK WORK PROTECTION § 211.6 Methods of affixation and placement of mask work notice. (a) General. (1) This section specifies methods of affixation and...

  15. Micromachined cutting blade formed from {211}-oriented silicon

    Energy Technology Data Exchange (ETDEWEB)

    Fleming, James G.; Sniegowski, Jeffry J.; Montague, Stephen

    2003-09-09

    A cutting blade is disclosed fabricated of micromachined silicon. The cutting blade utilizes a monocrystalline silicon substrate having a {211} crystalline orientation to form one or more cutting edges that are defined by the intersection of {211} crystalline planes of silicon with {111} crystalline planes of silicon. This results in a cutting blade which has a shallow cutting-edge angle .theta. of 19.5.degree.. The micromachined cutting blade can be formed using an anisotropic wet etching process which substantially terminates etching upon reaching the {111} crystalline planes of silicon. This allows multiple blades to be batch fabricated on a common substrate and separated for packaging and use. The micromachined cutting blade, which can be mounted to a handle in tension and optionally coated for increased wear resistance and biocompatibility, has multiple applications including eye surgery (LASIK procedure).

  16. Micromachined cutting blade formed from {211}-oriented silicon

    Energy Technology Data Exchange (ETDEWEB)

    Fleming, James G. (Albuquerque, NM); Fleming, legal representative, Carol (Burbank, CA); Sniegowski, Jeffry J. (Tijeras, NM); Montague, Stephen (Albuquerque, NM)

    2011-08-09

    A cutting blade is disclosed fabricated of micromachined silicon. The cutting blade utilizes a monocrystalline silicon substrate having a {211} crystalline orientation to form one or more cutting edges that are defined by the intersection of {211} crystalline planes of silicon with {111} crystalline planes of silicon. This results in a cutting blade which has a shallow cutting-edge angle .theta. of 19.5.degree.. The micromachined cutting blade can be formed using an anisotropic wet etching process which substantially terminates etching upon reaching the {111} crystalline planes of silicon. This allows multiple blades to be batch fabricated on a common substrate and separated for packaging and use. The micromachined cutting blade, which can be mounted to a handle in tension and optionally coated for increased wear resistance and biocompatibility, has multiple applications including eye surgery (LASIK procedure).

  17. Spitzer spectral line mapping of the HH211 outflow

    DEFF Research Database (Denmark)

    Dionatos, Odyssefs; Nisini, Brunella; Cabrit, Sylvie;

    2010-01-01

    Aims: We employ archival Spitzer slit-scan observations of the HH211 outflow in order to investigate its warm gas content, assess the jet mass flux in the form of H2 and probe for the existence of an embedded atomic jet. Methods: Detected molecular and atomic lines are interpreted by means of emi...... uncertainties on jet speed and shock conditions are too large for a definite conclusion....

  18. Phonon spectral densities of Cu surfaces: Application to Cu(211)

    Science.gov (United States)

    Mărinică, M.-C.; Raşeev, G.; Smirnov, K. S.

    2001-05-01

    Power phonon spectra of vicinal stepped surfaces of Cu(211) have been calculated using a molecular dynamics method combined with a semiempirical potential. The potential is based on an analytic form of inverse powers proposed by Finnis and Sinclair with the parametrization of Sutton and Chen. One of the four independent parameters of the potential was rescaled to reproduce the bulk phonon spectrum of Cu while retaining other properties of the bulk Cu close to the experimental values. Using this potential, we calculated the power surface phonon spectra, projection of the spectra at the high-symmetry points of surface Brillouin zone (SBZ), and the mean square displacements (MSD's) of atoms of the Cu(211) surface. The calculated projected phonon spectra at Γ¯ and at two new SBZ points (at X¯ and Y¯) compare favorably with experiment and theory when available. The MSD of the Cu(211) surface is also well reproduced and its temperature dependence shows that anharmonicity of the atomic motion becomes important above 200 K.

  19. 75 FR 33738 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-524 Series and RB211 Trent 500, 700, and 800...

    Science.gov (United States)

    2010-06-15

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... plc (RR) RB211-524 Series and RB211 Trent 500, 700, and 800 Series Turbofan Engines AGENCY:...

  20. Optimisation study of {alpha}-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes

    Energy Technology Data Exchange (ETDEWEB)

    Groppi, F. [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, I-20090 Segrate, Milan (Italy)]. E-mail: flavia.groppi@mi.infn.it; Bonardi, M.L. [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, I-20090 Segrate, Milan (Italy); Birattari, C. [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, I-20090 Segrate, Milan (Italy); Menapace, E. [ENEA, Division for Advanced Physics Technologies, via Don Fiammelli 2, I-40128 Bologna (Italy); Abbas, K. [Institute for Health and Consumer Protection, IHCP, JRC-Ispra, via E. Fermi, I-21020 Varese (Italy); Holzwarth, U. [Institute for Health and Consumer Protection, IHCP, JRC-Ispra, via E. Fermi, I-21020 Varese (Italy); Alfarano, A. [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, I-20090 Segrate, Milan (Italy); Institute for Health and Consumer Protection, IHCP, JRC-Ispra, via E. Fermi, I-21020 Varese (Italy); Morzenti, S. [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, I-20090 Segrate, Milan (Italy); Zona, C. [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, I-20090 Segrate, Milan (Italy); Alfassi, Z.B. [Department of Nuclear Engineering, Ben Gurion University of Negev, Beer-Sheva, Il-84105 (Israel)

    2005-12-01

    The production of no-carrier-added (NCA) {alpha}-emitter {sup 211}At/{sup 211g}Po radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the {sup 209}Bi({alpha},2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the {gamma}-emitter {sup 210}At and its long half-lived {alpha}-emitting daughter {sup 210}Po is optimised and minimised by appropriate choice of energy and energy loss of {alpha} particle beam. The measured excitation functions for production of the main radioisotopic impurity {sup 210}At{yields}{sup 210}Po are compared with theoretical predictions from model calculations performed at ENEA.

  1. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  2. Measurement of the (211)Pb half-life using recoil atoms from (219)Rn decay.

    Science.gov (United States)

    Aitken-Smith, P M; Collins, S M

    2016-04-01

    The radioactive half-life of (211)Pb was measured, by α-particle counting of samples of radiochemically pure (211)Pb in equilibrium with its α-emitting progeny, (211)Bi and (211)Po. The samples were prepared by the collection of (215)Po recoil atoms from the decay of the (219)Rn decay progeny produced from a (223)Ra sample onto stainless steel discs. The radioactive decay of the (211)Pb was measured utilising a 2π proportional counter operating on the α plateau. A half-life of 36.164 (13)min was determined, which is in agreement with currently available literature. A full uncertainty budget is presented. A recommended half-life of T1/2((211)Pb)=36.161 (17)min has been evaluated from the current literature values. PMID:26773817

  3. Clinical significance of serum CYFRA 21-1 in gastric cancer.

    OpenAIRE

    Nakata, B.; Chung, Y. S.; Kato, Y.; Ogawa, M; Ogawa, Y; Inui, A.; Maeda, K; Sawada, T; Sowa, M.

    1996-01-01

    We studied the clinical significance of the soluble cytokeratin 19 fragment detected with monoclonal antibody CYFRA 21-1 in the sera of patients with histologically proven gastric cancer. Sera of 110 patients with gastric cancer were analysed for CYFRA 21-1 levels by a two-step sandwich enzyme immunoassay. There were no significant differences between CYFRA 21-1 levels and the histotype, depth of invasion or vessel invasion. However, CYFRA 21-1 was significantly higher in the presence of peri...

  4. New tumor markers for breast carcinoma is serum CYFRA 21-1%乳腺癌新的肿瘤标志物-CYFRA21-1

    Institute of Scientific and Technical Information of China (English)

    刘志勇; 欧阳忠; 邹小明

    2010-01-01

    目的 探讨CYFRA21-1在乳腺癌中的表达情况及其临床意义.方法 分别检测86例原发性乳腺癌,14例复发性乳腺癌,22例良性乳腺肿瘤,25例正常人群中血清CYFRA21-1、CEA、CA153的表达情况,并检测血清CYFRA21-1含量与临床病理特征、预后及无病生存时间的关系.结果 乳腺良性肿瘤人群与正常人群中CYFRA21-1的差别无统计学意义.CYFRA21-1在Ⅳ期乳腺癌及复发性乳腺癌中的阳性率分别为60%和64.2%,其阳性率高于CA153和CEA.在血运性复发性乳腺癌病例中,其灵敏度较高,为89%.随着TNM分期的增加CYFRA21-1的水平逐渐升高.CYFRA21-1与CEA无统计学关联,与CA153有轻度统计学关联,单因素及多因素分析均显示:CYFRA21-1可作为判断乳腺癌预后的一个独立指标.结论 检测CYFRA21-1水平对检测乳腺癌复发及评估治疗效果有非常大的价值.

  5. IMMUNORADIOMETRICAL MEASUREMENT OF CYTOKERATIN FRAGMENT 21-1 (CYFRA 21-1) IN NORMAL HEALTHY NONPREGNANT AND PREGNANT JAPANESE WOMEN

    OpenAIRE

    稲葉, 憲之; イナバ, ノリユキ; INABA, Noriyuki; 岡嶋, 祐子; オカジマ, ユウコ; Okajima, Yuko; 深沢, 一雄; フカサワ, イチオ; FUKASAWA, Ichio; 太田, 順子; オオタ, ヨリコ; OTA, Yoriko; 田中, 圭; タナカ, キヨシ; Tanaka, Kiyoshi

    1993-01-01

    ヒトサイトケラチン19に対する2種のマウスモノクローナル抗体,KS 19.1とBM 19.21を用いたワンステップサンドイッチ固相法radioimmunoassay (RIA)を使用して,健常日本女性および男性の血中cytokeratin fragment 21-1 (CYFRA 21-1)を測定,正常値およびカットオフ値(平均値+2SD)を検討した。また,月経周期における血中値の変動,さらに妊娠時血中値の変化,および陽性率を妊娠初期,中期,後期に分けて検討した。分娩時,母体血,羊水,臍帯動静脈血,胎盤後貯留血液および産褥3日目の母体血を採取,各検体におけるCYFRA 21-1を測定し,その産生源および血中値半減期についても考察を加えた。著者らはすでにCYFRA 21-1の婦人科悪性腫瘍に対する腫瘍マーカーとしての意義を報告したが,本論文は産婦人科領域における新しいサイトケラチン関連腫瘍マーカーのカットオフ値,月経周期および妊娠・分娩時における血中値変動等,基本的なデータに関する報告である。...

  6. 48 CFR 552.211-92 - Radio Frequency Identification (RFID) using passive tags.

    Science.gov (United States)

    2010-10-01

    ... with 48 CFR clause 252.211-7006. Shipments to GSA Distribution Centers with final destinations to DLA and DoD shall be in compliance to 48 CFR 252.211-7006. Copies may be obtained from http://www.access.gpo.gov/nara/cfr/cfr-table-search.html. (End of clause)...

  7. 22 CFR 211.9 - Liability for loss damage or improper distribution of commodities.

    Science.gov (United States)

    2010-04-01

    ... market price, the f.o.b. or f.a.s. commercial export price of the commodity at the time and place of... for these deposits shall be at the highest rate of exchange legally obtainable on the date of deposit... distribution of commodities. 211.9 Section 211.9 Foreign Relations AGENCY FOR INTERNATIONAL...

  8. 49 CFR 375.211 - Must I have an arbitration program?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Must I have an arbitration program? 375.211... Services to My Customers General Responsibilities § 375.211 Must I have an arbitration program? (a) You must have an arbitration program for individual shippers to resolve disputes about property loss...

  9. 5 CFR 842.211 - Senior Executive Service, Defense Intelligence Senior Executive Service, and Senior Cryptologic...

    Science.gov (United States)

    2010-01-01

    ... Intelligence Senior Executive Service, and Senior Cryptologic Executive Service. 842.211 Section 842.211... Intelligence Senior Executive Service, and Senior Cryptologic Executive Service. (a) A member of the Senior Executive Service, the Defense Intelligence Senior Executive Service, or the Senior Cryptologic...

  10. 48 CFR 952.211-71 - Priorities and allocations for energy programs (contracts).

    Science.gov (United States)

    2010-10-01

    ... Allocations System (DPAS) regulation (15 CFR part 700) in obtaining materials (including equipment), services... for energy programs (contracts). 952.211-71 Section 952.211-71 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions...

  11. 48 CFR 952.211-70 - Priorities and allocations for energy programs (solicitations):

    Science.gov (United States)

    2010-10-01

    ... System (DPAS) regulation (15 CFR part 700) (Contracting Officer check appropriate box.) (End of provision) ... for energy programs (solicitations): 952.211-70 Section 952.211-70 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text...

  12. 12 CFR 211.7 - Voluntary liquidation of Edge and agreement corporations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Voluntary liquidation of Edge and agreement corporations. 211.7 Section 211.7 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL BANKING OPERATIONS (REGULATION K) International Operations of U.S....

  13. 49 CFR 240.211 - Procedures for making the determination on performance skills.

    Science.gov (United States)

    2010-10-01

    ... performance skills. 240.211 Section 240.211 Transportation Other Regulations Relating to Transportation... determination on performance skills. (a) Each railroad, prior to initially certifying or recertifying any person... demonstrated, in accordance with the requirements of § 240.127 of this part, the skills to safely...

  14. 5 CFR 843.211 - Determining when children prevent payment of the unexpended balance.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Determining when children prevent payment of the unexpended balance. 843.211 Section 843.211 Administrative Personnel OFFICE OF PERSONNEL... unexpended balance. Someone entitled to an annuity for purposes of §§ 843.203 and 843.204 includes a...

  15. 40 CFR 211.204-1 - Information content of -primary label.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Information content of -primary label. 211.204-1 Section 211.204-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... content of -primary label. The information to appear on the -primary label must be according -to §...

  16. 12 CFR 211.3 - Foreign branches of U.S. banking organizations.

    Science.gov (United States)

    2010-01-01

    ... CFR part 204). (e) Conditional approval; access to information. The Board may impose such conditions... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Foreign branches of U.S. banking organizations. 211.3 Section 211.3 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL...

  17. 12 CFR 211.23 - Nonbanking activities of foreign banking organizations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Nonbanking activities of foreign banking organizations. 211.23 Section 211.23 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL BANKING OPERATIONS (REGULATION K) Foreign Banking Organizations §...

  18. 12 CFR 211.22 - Interstate banking operations of foreign banking organizations.

    Science.gov (United States)

    2010-01-01

    ... production office in accordance with the provisions in § 208.7 of Regulation H (12 CFR 208.7). ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Interstate banking operations of foreign banking organizations. 211.22 Section 211.22 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF...

  19. 12 CFR 347.211 - Examination of branches of foreign banks.

    Science.gov (United States)

    2010-01-01

    ... composite ROCA supervisory rating (which rates risk management, operational controls, compliance, and asset... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Examination of branches of foreign banks. 347.211 Section 347.211 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND...

  20. 45 CFR 400.211 - Methodology to be used to determine time-eligibility of refugees.

    Science.gov (United States)

    2010-10-01

    ...-eligibility of refugees. 400.211 Section 400.211 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Federal Funding Federal Funding for Expenditures for...

  1. 43 CFR 30.211 - Will the notice be published in a newspaper?

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Will the notice be published in a newspaper? 30.211 Section 30.211 Public Lands: Interior Office of the Secretary of the Interior INDIAN... newspaper? The judge may cause advance notice of hearing to be published in a newspaper of...

  2. On convergence (2,1,...,1-periodic branched continued fraction of the special form

    Directory of Open Access Journals (Sweden)

    D. I. Bodnar

    2016-01-01

    Full Text Available (2,1,...,1-periodic branched continued fraction of the special form is defined. Conditions of convergence are established for 2-periodic continued fraction and (2,1,...,1-periodic branched continued fraction of the special form. Truncation error bounds are estimated for these fractions under additional conditions.

  3. 48 CFR 1552.211-79 - Compliance with EPA Policies for Information Resources Management.

    Science.gov (United States)

    2010-10-01

    ... Policies for Information Resources Management. 1552.211-79 Section 1552.211-79 Federal Acquisition... Information Resources Management (OCT 2000) (a) Definition. Information Resources Management (IRM) is defined... includes both information itself, and the management of information and related resources such as...

  4. Influence of preparation conditions on 211 particle refinement in YBCO bulk superconductors with Ce addition

    Energy Technology Data Exchange (ETDEWEB)

    Diko, Pavel, E-mail: dikos@saske.sk; Volochová, Daniela; Radušovská, Monika; Zmorayová, Katarína; Šefčiková, Martina; Antal, Vitalij; Jurek, Karel; Jirsa, Miloš; Kováč, Jozef

    2013-11-15

    Highlights: •CeO{sub 2} causes coarsening of Y211 particles in nominal composition Y{sub 1.5}Ba{sub 2}Cu{sub 3}O{sub x}. •Y211 particles grow during sintering at 940 °C. •High local density of Y211 particles hinders their growth at sintering stage. •Addition of BaCeO{sub 3} leads to smaller Y211 particles. •Skeleton of Y211 particles prevents pollution of grown samples. -- Abstract: The influence of CeO{sub 2} and BaCeO{sub 3} addition and the influence of processing conditions on Y{sub 2}BaCuO{sub 5} (Y211) particle size and particle distribution in melt-processed YBa{sub 2}Cu{sub 3}O{sub 7}/Y{sub 2}BaCuO{sub 5} (Y123/Y211) bulk superconductors with nominal composition Y{sub 1.5}Ba{sub 2}Cu{sub 3}O{sub x} was investigated. Ce dissolved in the peritectic melt can actively hinder the Y211 particle growth by the Ostwald ripening process at melting stage. At sintering of intensively milled samples, Y211 particles in the charge free of CeO{sub 2} are smaller than Y211 particles formed in the charge with CeO{sub 2} addition and this behaviour can be related to the melt formation around added CeO{sub 2}. The Y211 particle refinement in the mildly milled samples with large Y123 particles in the pressed green bodies is caused by very dense Y211 skeleton resistant to melt formation at the sintering stage. This skeleton is a barrier for pollution of the sample from the substrate and from the seed. BaCeO{sub 3} added instead CeO{sub 2} causes significant Y211 particle refinement also in the samples with homogenously distributed Y211 particles.

  5. 5 CFR 875.211 - What happens if my eligibility status changes after I submit my application?

    Science.gov (United States)

    2010-01-01

    ... provisions of 5 U.S.C. 8412(g), or retire after you submit an application for coverage, but before your... changes after I submit my application? 875.211 Section 875.211 Administrative Personnel OFFICE OF... PROGRAM Eligibility § 875.211 What happens if my eligibility status changes after I submit my...

  6. Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model

    International Nuclear Information System (INIS)

    A paired-label biodistribution was performed in athymic mice bearing SK-N-SH human neuroblastoma xenografts to compare the tissue uptake of meta-[211At]astatobenzylguanidine ([211At]MABG) and [131I]MIBG. Significantly higher (p 211At]MABG was seen in tumor (3.8 ± 0.8% ID/g vs. 3.1 ± 0.7% ID/g at 8 h) compared to [131I]MIBG. Desipramine reduced tumor uptake of [211At] MABG by 43%, suggesting that its accumulation was related to the specific uptake-1 mechanism. Higher uptake of [211At]MABG was also seen in normal tissue targets such as heart (6.0 ± 0.9% ID/g vs. 4.5 ± 0.8% ID/g at 8 h; p 211At]MABG by 1.5-fold while reducing uptake in heart and several other normal tissues. The vesicular uptake inhibitor tetrabenazine reduced heart uptake by 30% without reducing the tumor uptake. These results suggest such strategies might be useful for improving [211At]MABG tumor-to-normal tissue ratios

  7. Preparation and preclinical evaluation of 211At-labelled compounds for α-particle radiotherapy

    International Nuclear Information System (INIS)

    The interest for α-particle emitters in internal radiotherapy is increasing due to improved conjugation chemistry. Experimental work has concentrated on 211At and 212Bi since these to nuclides have radiochemical and physical properties suitable for medical application. In this report it is demonstrated that biologically active 211At-labelled compounds can be prepared within a relatively short time allowing utilization of this 7.2 h α-particle. It is further shown that 211At-TP-3 treatment of human osteosarcoma in vitro gives promising therapeutic ratios. 76 refs., 5 figs., 3 tabs

  8. CYFRA 21-1 serum levels in women with adnexal masses and inflammatory diseases.

    OpenAIRE

    Tempfer, C; Hefler, L; Heinzl, H; Loesch, A.; Gitsch, G; Rumpold, H.; Kainz, C.

    1998-01-01

    The aim of the present study was to evaluate the clinical usefulness of the cytokeratin marker CYFRA 21-1 as a screening marker for ovarian cancer, as a predictive marker in patients with adnexal masses and as a prognostic marker in women suffering from ovarian cancer. In order to determine the specificity of the CYFRA 21-1 test, we have investigated CYFRA 21-1 serum levels in several benign conditions. This retrospective study comprises 37 patients suffering from ovarian cancer FIGO stages I...

  9. Preparation and preclinical evaluation of {sup 211}At-labelled compounds for {alpha}-particle radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, R.H.

    1994-12-31

    The interest for {alpha}-particle emitters in internal radiotherapy is increasing due to improved conjugation chemistry. Experimental work has concentrated on {sup 211}At and {sup 212}Bi since these to nuclides have radiochemical and physical properties suitable for medical application. In this report it is demonstrated that biologically active {sup 211}At-labelled compounds can be prepared within a relatively short time allowing utilization of this 7.2 h {alpha}-particle. It is further shown that {sup 211}At-TP-3 treatment of human osteosarcoma in vitro gives promising therapeutic ratios. 76 refs., 5 figs., 3 tabs.

  10. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  11. Morphological stability of Sm123 superconductor during peritectic solidification from Sm211 + L mixture

    International Nuclear Information System (INIS)

    The interface stability of the Sm 123 superconductor was analyzed in accordance with the constitutional undercooling criterion. As the single-crystal growth of the 123 phase is largely dependent on the growth-interface stability, a quantitative analysis was very much required. From this analysis, it was clarified that the constitutional undercooling must exist in the liquid when the 123 growth interface comes close to a 211 particle during the peritectic solidification. It was also predicted that the larger 211 particle radius, smaller volume fraction of the 211 particles, larger growth rate, or smaller imposed temperature gradient would cause easy occurrence of the constitutional undercooling ahead of the 123 growth interface. Taking into account the nucleation at the L/211 interface just ahead of the 123 growth front due to the constitutional undercooling, the transition of 123 growth from a planar-interface morphology to an equiaxed blocky morphology was investigated quantitatively and qualitatively

  12. CYFRA 21-1 in urine: a diagnostic marker for endometriosis?

    Science.gov (United States)

    Gjavotchanoff, Risto

    2015-01-01

    Diagnostic workup of endometriosis usually involves laparoscopic inspection and histological examination of biopsies. Unequivocal laboratory parameters for this ailment have not been available in routine diagnostic evaluations thus far. In this study, we examined urine concentrations of cytokeratin 19 (CYFRA 21-1), a structural protein specific for epithelia. We performed immunoassays for CYFRA 21-1 in urine samples from women afflicted with endometriosis throughout their menstrual cycle. We observed a significant increase in CYFRA 21-1 concentrations, corrected by creatinine levels, in the late follicular phase as compared with the level in healthy controls. We conclude that cyclically increased CYFRA 21-1 concentrations in urine could serve as a valuable noninvasive diagnostic parameter in the workup of clinically manifesting endometriosis. PMID:25709504

  13. Increases in Serum CYFRA21-1 Concentration during Successful Treatment with Crizotinib

    OpenAIRE

    Kanaji, Nobuhiro; Tadokoro, Akira; Watanabe, Naoki; Inoue, Takuya; Ishii, Tomoya; Dobashi, Hiroaki; Bandoh, Shuji

    2014-01-01

    Case series Patient: — Final Diagnosis: — Symptoms: — Medication: — Clinical Procedure: — Specialty: — Objective: Unexpected drug reaction Background: Increases in tumor marker concentrations usually suggest disease progression. Cases Report: We here describe on 3 patients with non-small cell lung cancer whose serum concentrations of CYFRA21-1 increased in spite of successful treatment with crizotinib. Discontinuation of crizotinib resulted in a rapid decrease in serum CYFRA21-1 concentration...

  14. A Comparison of Classical and H-Type Bovine Spongiform Encephalopathy Associated with E211K Prion Protein Polymorphism in Wild-Type and EK211 Cattle Following Intracranial Inoculation

    Science.gov (United States)

    Moore, S. Jo; West Greenlee, M. Heather; Smith, Jodi D.; Vrentas, Catherine E.; Nicholson, Eric M.; Greenlee, Justin J.

    2016-01-01

    In 2006, a case of H-type bovine spongiform encephalopathy (BSE-H) was diagnosed in a cow that was associated with a heritable polymorphism in the bovine prion protein gene (PRNP) resulting in a lysine for glutamate amino acid substitution at codon 211 (called E211K) of the prion protein. Although the prevalence of this polymorphism is low, cattle carrying the K211 allele may be predisposed to rapid onset of BSE-H when exposed or to the potential development of a genetic BSE. This study was conducted to better understand the relationship between the K211 polymorphism and its effect on BSE phenotype. BSE-H from the US 2006 case was inoculated intracranially (IC) in one PRNP wild-type (EE211) calf and one EK211 calf. In addition, one wild-type calf and one EK211 calf were inoculated IC with brain homogenate from a US 2003 classical BSE case. All cattle developed clinical disease. The survival time of the E211K BSE-H inoculated EK211 calf (10 months) was shorter than the wild-type calf (18 months). This genotype effect was not observed in classical BSE inoculated cattle (both 26 months). Significant changes in retinal function were observed in H-type BSE challenged cattle only. Cattle challenged with the same inoculum showed similar severity and neuroanatomical distribution of vacuolation and disease-associated prion protein deposition in the brain, though differences in neuropathology were observed between E211K BSE-H and classical BSE inoculated animals. Western blot results for brain tissue from challenged animals were consistent with the inoculum strains. This study demonstrates that the phenotype of E211K BSE-H remains stable when transmitted to cattle without the K211 polymorphism, and exhibits a number of features that differ from classical BSE in both wild-type and heterozygous EK211 animals.

  15. CYFRA 21-1 as a tumor marker for squamous cell carcinoma of the esophagus.

    Science.gov (United States)

    Nakamura, T; Ide, H; Eguchi, R; Hayashi, K; Takasaki, K; Watanabe, S

    1998-01-01

    This study assessed the clinical value of CYFRA 21-1 in comparison with squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) in patients with esophageal squamous cell carcinoma. In 112 primary cancer patients, the diagnostic sensitivity of CYFRA 21-1 (33.9%) was superior to SCC-Ag (28.6%), CEA (12.5%), and CA19-9 (6.3%). Levels of CYFRA 21-1 were closely correlated with TNM stage and wee below the cutoff value in all 21 patients with stage I disease. All 38 patients with a CYFRA 21-1 level over the cutoff value among the 80 patients who underwent esophagectomy had lymph node metastases (pN1). A correlation was found between CYFRA 21-1 levels and clinical response in serial measurements of 21 patients who received chemotherapy or chemo radiotherapy. Our findings suggest that CYFRA 21-1 is not useful for diagnosis, but that it is valuable for monitoring the efficacy of therapy.

  16. Production of α-particle emitting 211At using 45 MeV α-beam

    Science.gov (United States)

    Kim, Gyehong; Chun, Kwonsoo; Park, Sung Ho; Kim, Byungil

    2014-06-01

    Among the α-particle emitting radionuclides, 211At is considered to be a promising radionuclide for targeted cancer therapy due to its decay properties. The range of alpha particles produced by the decay of 211At are less than 70 µm in water with a linear energy transfer between 100 and 130 keV µm-1, which are about the maximum relative biological effectiveness for heavy ions. It is important to note that at the present time, only a few of cyclotrons routinely produce 211At. The direct production method is based on the nuclear reactions 209Bi(α,2n)211At. Production of the radionuclide 211At was carried out using the MC-50 cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS). To ensure high beam current, the α-beam was extracted with an initial energy of 45 MeV, which was degraded to obtain the appropriate α-beam energy. The calculations of beam energy degradation were performed utilizing the MCNPX. Alumina-baked targets were prepared by heating the bismuth metal powder onto a circular cavity in a furnace. When using an Eα, av of 29.17 MeV, the very small contribution of 210At confirms the right choice of the irradiation energy to obtain a pure production of 211At isotope.

  17. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  18. The clinical utility of a new tumor marker for lung cancer Cyfra 21-1; Uzytecznosc kliniczna nowego markera raka pluca Cyfra 21-1

    Energy Technology Data Exchange (ETDEWEB)

    Cynowska, B.; Slominski, J.M.; Wolf, H.; Wyrwinski, J.; Skokowski, J.; Kaminski, M. [Katedra i Klinika Chorob Pluc i Gruzlicy, Akademia Medyczna, Gdansk (Poland)

    1997-12-31

    Cytokeratins expressed in epithelial cells from respiratory epithelium are also expressed in situ by lung cancers. The Cyfra 21-1 assay is a newly developed test which measures in serum fragments of cytokeratin 19. The aim of our study was to asses the clinical utility of the protein as a marker for lung cancer. We evaluated this marker in 196 patients with lung cancer , 33 patients with being lung diseases and 60 healthy individuals. Significantly higher levels were observed in patients with lung cancer but there was not difference between histological types of lung cancer. Concentration of Cyfra 21-1 significantly correlated with the stage of disease and the highest levels were found in patients with metastases. Consequently the marker was significantly lower in patients who were operated upon when compared with unresectable ones p,0.0001. In addition we observed a correlation between Cyfra 21-1 concentration and survival time. Cyfra 21-1 as a tumor marker is clinically useful especially for NSCLC. (author) 11 refs, 2 tab

  19. Preoperative CYFRA 21-1 level as a prognostic indicator in resected primary squamous cell lung cancer.

    OpenAIRE

    Niklinski, J.; Furman, M; Burzykowski, T.; Chyczewski, L.; Laudanski, J.; Chyczewska, E; Rapellino, M.

    1996-01-01

    The CYFRA 21-1 assay is a test that has been developed recently for detection of a cytokeratin 19 fragment in serum. A diagnostic role for CYFRA 21-1 has already been proposed. The question of whether this marker is prognostically significant is important in clarifying the role of CYFRA 21-1 in clinical practice. The aim of this study was to evaluate the prognostic significance of elevated preoperative CYFRA 21-1 levels in patients with resected primary squamous-cell lung cancer (SqCC). Serum...

  20. Serum squamous cell carcinoma antigen and CYFRA 21-1 in cervical cancer treatment

    International Nuclear Information System (INIS)

    Purpose: To analyze whether serum squamous cell carcinoma (SCC) antigen and cytokeratin-19 fragments (CYFRA) levels can assist in selecting patients with locally advanced cervical cancer who will benefit from combined treatment or additive surgery. Methods and Materials: Of 114 patients with cervical cancer Stage IB-IV, the first 39 patients received radiotherapy, the following 75 patients received identical radiotherapy plus concomitant chemotherapy (3 cycles of carboplatin and 5-fluorouracil). SCC antigen and CYFRA 21-1 serum levels were measured before treatment, after therapy, and during follow-up. Baseline tumor markers were related to tumor stage and size and clinical outcome. Results: Before treatment, SCC antigen was elevated (>1.9 μg/L) in 60% and CYFRA 21-1 (>2.2 μg/L) in 46% of patients. For all patients, disease-free survival (DFS) was better after combined treatment (67% vs. 43%, p<0.0005). For patients with elevated baseline SCC antigen, DFS was better after combination therapy (67% vs. 27%, p=0.001) which resulted more frequently in a normal SCC antigen (93% vs. 65%, p=0.004). In contrast, in those with a normal baseline CYFRA 21-1, combined therapy resulted in a better DFS (p=0.04). Patients who achieved a normal SCC antigen or CYFRA 21-1 after treatment had a better DFS (respectively 63 vs. 17% and 64 vs. 30%). Elevated SCC antigen posttreatment indicated residual tumor in 11/12 patients (92%), elevated CYFRA 21-1 in 7/10 patients (70%). Forty-seven patients had a tumor recurrence. At recurrence, SCC antigen was raised in 70% and CYFRA 21-1 in 69%. Conclusions: In patients with an elevated pretreatment SCC antigen, SCC antigen normalized more frequently with combined treatment and those patients had a better DFS. Elevated SCC antigen or CYFRA 21-1 levels after treatment completion indicated residual tumor in respectively 92% and 70%. The presence of elevated posttreatment levels of SCC antigen or CYFRA 21-1 indicates the need for additional

  1. CYFRA 21-1 in urine: a diagnostic marker for endometriosis?

    Directory of Open Access Journals (Sweden)

    Gjavotchanoff R

    2015-02-01

    Full Text Available Risto Gjavotchanoff1,2 1Department of Laboratory Medicine, Bodenseelabor, Hörbranz, Austria; 2Institute of Anatomy II, University of Jena, Jena University Hospital, Jena, Germany Abstract: Diagnostic workup of endometriosis usually involves laparoscopic inspection and histological examination of biopsies. Unequivocal laboratory parameters for this ailment have not been available in routine diagnostic evaluations thus far. In this study, we examined urine concentrations of cytokeratin 19 (CYFRA 21-1, a structural protein specific for epithelia. We performed immunoassays for CYFRA 21-1 in urine samples from women afflicted with endometriosis throughout their menstrual cycle. We observed a significant increase in CYFRA 21-1 concentrations, corrected by creatinine levels, in the late follicular phase as compared with the level in healthy controls. We conclude that cyclically increased CYFRA 21-1 concentrations in urine could serve as a valuable noninvasive diagnostic parameter in the workup of clinically manifesting endometriosis. Keywords: biomarkers, menstrual cycle, CYFRA 21-1, immunoassay, noninvasive diagnosis

  2. LABELING McAb 3H11 AND ITS Fab FRAGMENT WITH 211At AND THEIR IMMUNOREACTIVITIES AND INJURY EFFECTS ON HUMAN GASTRIC CANCER CELLS

    Institute of Scientific and Technical Information of China (English)

    刘宁; 罗德元; 等

    1995-01-01

    An antigastric cancer monoclonal antibody,3H11,and its Fab fragment,were labeled using p-(211At)-astatobenzoic acid(pAtBA) intermediate,in the yields of more than 30%.The results of in vitro experiments show that 211 At-3H11 and 211At-3H11 Fab are stable,and have specific immunoreactivities and cytotoxic effects to human gastric cancer cell M85,The cytotoxic effects are dependent on the concentration of 211At-3H11 or 211 At-3H11 Fab and obviously stronger than that of Na211At.

  3. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  4. Preparation and preclinical evaluation of 211At-labelled compounds for α-particle radiotherapy

    International Nuclear Information System (INIS)

    The present work demonstrate that significant therapeutic gain can be achieved with 211At-labelled MoAbs on single tumour cells and microscopic disease. Β-emitters are less effective on microscopic disease because of radiation dispersion, while longer halflives (e.g., 90Y and 131I) allow favourable therapeutic ratios to be reached in larger tumors. 211At-labelled MoAbs may therefore possibly be used in combination with β-emitting RIC in systemically delivered radioimunnotherapy. Larger tumor nodules are then irradiated effectively due to cross-fire of the longer ranged β-particles while the fraction of tumour cells distributed as single cells and micrometastases may be more effectively radiated with 211At-RIC. 76 refs

  5. Appraising nuclear octupole moment contributions to the hyperfine structures in $^{211}$Fr

    CERN Document Server

    Sahoo, B K

    2015-01-01

    Hyperfine structures of $^{211}$Fr due to the interactions of magnetic dipole ($\\mu$), electric quadrupole ($Q$) and magnetic octupole ($\\Omega$) moments with the electrons are investigated using the relativistic coupled-cluster (RCC) theory with an approximation of singles, doubles and important valence triples excitations in the perturbative approach. Validity of our calculations are substantiated by comparing the results with their available experimental values. Its $Q$ value has also been elevated by combining the measured hyperfine structure constant of the $7p \\ ^2P_{3/2}$ state with our improved calculation. Considering the preliminary value of $\\Omega$ from the nuclear shell-model, its contributions to the hyperfine structures up to the $7d \\ ^2D_{5/2}$ low-lying states in $^{211}$Fr are estimated. Energy splittings of the hyperfine transitions in many states have been assessed to find out suitability to carry out their precise measurements so that $\\Omega$ of $^{211}$Fr can be inferred from them unam...

  6. A comparison of classical and H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism in wild type and EK211 cattle following intracranial inoculation

    Science.gov (United States)

    In 2006, a case of H-type bovine spongiform encephalopathy (BSE-H) was diagnosed in a cow that was associated with a heritable polymorphism in the bovine prion protein gene (PRNP) resulting in a lysine for glutamine amino acid substitution at codon 211 (called E211K) of the prion protein. Although t...

  7. Selective growth of CdTe on patterned CdTe/Si(211)

    OpenAIRE

    Seldrum, T.; Bommena, R.; Samain, Louise; Sivananthan, S.; Sporken, R.; Dumont, J.

    2008-01-01

    The authors have studied selective growth of cadmium telluride on Si(211) by molecular beam epitaxy (MBE). Patterned substrates were produced by optical lithography of MBE-grown CdTe/As/Si(211). Photoemission microscopy was used as the main tool to study selective growth. This is very powerful because Si or SiO2 can be very easily distinguished from areas covered with even small amounts of CdTe due to contrast from work function differences. It was found that CdTe grows on CdTe without sticki...

  8. Heteroepitaxy of CdTe on Ge(211)Substrates by Molecular Beam Epitaxy%Ge(211)衬底上分子束外延CdTe薄膜

    Institute of Scientific and Technical Information of China (English)

    李艳辉; 杨春章; 苏栓; 谭英; 高丽华; 赵俊

    2011-01-01

    采用分子束外延在3英寸Ge(211)衬底上生长了10 μm厚的CdTe(211)B薄膜.CdTe表面镜面光亮,3英寸范围厚度平均值9.72 μm,偏差0.3 μm;薄膜晶体质量通过X射线双晶迴摆曲线进行评价,FWHM平均值80.23 arcsec,偏差3.03 arcsec; EPD平均值为4.5×106cm-2.通过研究CdTe薄膜厚度与FWHM和EPD的关系,得到CdTe的理想厚度为8~9 μm.%The 10μm thick CdTe(211)B has been grown by molecular beam epitaxy(MBE) on Ge(211) substrate. The surface morphology of CdTe layers with a diameter of three inches is smooth and mirror-like. The average of thick is 9.72 μm, deviation 0.3 μm; The crystalline quality was measured by an X-ray double-crystal rocking curve, the average is 80.23 arcsec, deviation 3.03 arcsec; The EPD is 4.5 × 106cm -2. We has studied the effects of the thickness onFWHM and EPD for CdTe layer, the optimum thickness of CdTe layer is 8~9 μm.

  9. 23 CFR 633.211 - Implementation of the Clean Air Act and the Federal Water Pollution Control Act.

    Science.gov (United States)

    2010-04-01

    ... Pollution Control Act. Pursuant to regulations of the Environmental Protection Agency (40 CFR part 15) implementing requirements with respect to the Clean Air Act and the Federal Water Pollution Control Act are... Water Pollution Control Act. 633.211 Section 633.211 Highways FEDERAL HIGHWAY ADMINISTRATION,...

  10. 8 CFR 211.3 - Expiration of immigrant visas, reentry permits, refugee travel documents, and Form I-551.

    Science.gov (United States)

    2010-01-01

    ... permits, refugee travel documents, and Form I-551. 211.3 Section 211.3 Aliens and Nationality DEPARTMENT... Expiration of immigrant visas, reentry permits, refugee travel documents, and Form I-551. An immigrant visa, reentry permit, refugee travel document, or Form I-551 shall be regarded as unexpired if the...

  11. 12 CFR 211.601 - Status of certain offices for purposes of the International Banking Act restrictions on...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Status of certain offices for purposes of the International Banking Act restrictions on interstate banking operations. 211.601 Section 211.601 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM INTERNATIONAL...

  12. 21 CFR 211.84 - Testing and approval or rejection of components, drug product containers, and closures.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Testing and approval or rejection of components, drug product containers, and closures. 211.84 Section 211.84 Food and Drugs FOOD AND DRUG... with filth, insect infestation, or other extraneous adulterant shall be examined against...

  13. 25 CFR 211.42 - Annual rentals and expenditures for development on leases other than oil and gas, and geothermal...

    Science.gov (United States)

    2010-04-01

    ... other than oil and gas, and geothermal resources. 211.42 Section 211.42 Indians BUREAU OF INDIAN AFFAIRS... other than oil and gas, and geothermal resources. (a) Unless otherwise authorized by the Secretary, a lease for minerals other than oil, gas and geothermal resources shall provide for a yearly...

  14. 40 CFR 33.211 - What is the process for appealing or challenging an EPA MBE or WBE certification determination?

    Science.gov (United States)

    2010-07-01

    ... challenging an EPA MBE or WBE certification determination? 33.211 Section 33.211 Protection of Environment... process for appealing or challenging an EPA MBE or WBE certification determination? (a) An entity which has been denied MBE or WBE certification by EPA OSDBU under § 33.205 or § 33.209 may appeal...

  15. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  16. Prognostic value of serum cytokeratin 19 fragments (Cyfra 21-1) in patients with non-small cell lung cancer.

    Science.gov (United States)

    Xu, Youtao; Xu, Lei; Qiu, Mantang; Wang, Jie; Zhou, Qing; Xu, Lin; Wang, Jian; Yin, Rong

    2015-01-01

    The role of serum CYFRA 21-1 level in patients with non-small cell lung cancer (NSCLC) remains to be defined. To re-evaluate the impact of serum CYFRA 21-1 in NSCLC survival, we performed this meta-analysis. Databases were searched to identify relevant studies reported after the publication of a meta-analysis in 2004. Totally, 31 studies with 6394 patients were included in this meta-analysis. The pooled Hazard ratios (HRs) indicated that high CYFRA 21-1 level was associated with poor prognosis on overall survival (OS) in patients with NSCLC (HR = 1.60; 95%CI = 1.36-1.89; P CYFRA 21-1 related to PFS was performed and pooled HR was 1.41 (95%CI = 1.19-1.69; P CYFRA 21-1 is a negative prognostic indicator of patients with NSCLC. PMID:25901419

  17. Cytokeratin 19 fragment antigen 21-1 as an independent predictor for definitive chemoradiotherapy sensitivity in esophageal squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    YAN Hong-jiang; WANG Ren-ben; ZHU Kun-li; JIANG Shu-mei; ZHAO Wei; XU Xiao-qing; FENG Rui

    2012-01-01

    Background Patients with esophageal squamous cell carcinoma (ESCC) undergoing definitive chemoradiotherapy (CRT) seem to have a disparity in therapeutic response.The identification of CRT sensitivity-related clinicopathological factors would be helpful for selecting patients most likely to benefit from CRT.Cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and carcinoembryonic antigen (CEA) have been reported as useful tumor markers for esophageal cancer.The aim of this study was to examine the predictive value of CYFRA21-1 in comparison with CEA and other clinicopathological factors in patients with ESCC treated with definitive CRT.Methods Pretreatment serum CYFRA21-1 and CEA levels were measured by immunoradiometric assays.The relationships between pretreatment clinicopathological factors and the efficacy of CRT were analyzed.Overall survival (OS) was estimated by univariate and multivariate analysis.Results The results from a univariate analysis indicated that the efficacy of CRT was significantly associated with the serum levels of CYFRA21-1 and CEA before treatment (P=0.001 and P=0.023,respectively).It also indicated that the efficacy of CRT was significantly associated with the pretreatment tumor location (P=0.041).By Logistic regression analysis,the independent predictive factor associated with efficacy of CRT was CYFRA21-1 (P=0.002).The OS of the patients with high CYFRA 21-1 levels was worse than that of those with low CYFRA21-1 levels (P=0.001).In multivariate analysis,a low level of CYFRA21-1 was the most significant independent predictor of good OS (P=0.007).Conclusions CEA and tumor location may be useful in predicting the sensitivity of ESCC to CRT.CYFRA21-1 may be an independent predictor for definitive CRT sensitivity in ESCC.

  18. Diagnosis Value of the Detection of CYFRA21-1 in Non-small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Jundong GU

    2010-12-01

    Full Text Available Background and objective Cytokeratin-19 fragment (CYFRA21-1 is a soluble protein in serum, and may be a useful circulating tumor marker. The aim of this study is to investigate the diagnostic value of the peripheral blood CYFRA21-1 in non-small cell lung cancer (NSCLC. Methods The levels of peripheral blood CYFRA21-1 were detected in 107 patients with NSCLC and 51 patients with benign pulmonary diseases by enzyme linked immunosorbent assay, and ROC curve was used to analyse the results. Results Singificant difference of peripheral blood CYFRA21-1 levels was detected between the NSCLC group and benign pulmonary disease group (χ2=47.343, P < 0.001. At the threshold of 3.3 ng/mL, sensitivity and specificity of CYFRA21-1 as a serologic marker were 74.77% and 76.47%, respectively for any cancer. ROC curve showed that the under-curve area (AUC of CYFRA21-1 was 0.813 9. There was no significant difference of CYFRA21-1 between subtypes of NSCLC (χ2=0.450, P=0.799. The peripheral blood CYFRA21-1 level was elevated significantly in the patients with extensive disease (IIIb, IV compared with patients with limited disase (I, II, IIIb (χ2=7.057, P=0.008. Conclusion As a tumor marker CYFRA21-1 has relative high sensitivity and specificity for the diagnosis of NSCLC. Elevated peripheral blood CYFRA 21-1 levels were usually indicated extensive disease of NSCLC.

  19. Ground state charmed meson spectra for N_f=2+1+1

    CERN Document Server

    Rae, T D

    2015-01-01

    We present a preliminary study of the charmed meson spectra using the electrically neutral subset of the new Budapest-Marseille-Wuppertal N_f=2+1+1 gauge configurations that utilise the 3-HEX smeared clover action. The analysis is performed with a focus on the hyperfine splitting.

  20. 21 CFR 211.110 - Sampling and testing of in-process materials and drug products.

    Science.gov (United States)

    2010-04-01

    ... PHARMACEUTICALS Production and Process Controls § 211.110 Sampling and testing of in-process materials and drug... production process, e.g., at commencement or completion of significant phases or after storage for long... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Sampling and testing of in-process materials...

  1. 20 CFR 211.12 - Compensation credited for title VII benefits.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Compensation credited for title VII benefits... RETIREMENT ACT CREDITABLE RAILROAD COMPENSATION § 211.12 Compensation credited for title VII benefits. Payments made to an employee under title VII of the Regional Rail Reorganization Act of 1973 are...

  2. 12 CFR 211.45 - Accounting for fees on international loans.

    Science.gov (United States)

    2010-01-01

    ... accordance with generally accepted accounting principles. Interpretations ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Accounting for fees on international loans. 211... Accounting for fees on international loans. (a) Restrictions on fees for restructured international loans....

  3. 25 CFR 211.46 - Inspection of premises, books and accounts.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Inspection of premises, books and accounts. 211.46... premises, books and accounts. Lessees shall allow the Indian mineral owner, the Indian mineral owner's... and submit all related reports required by the lease and applicable regulations. Books and...

  4. Whole genome analysis of Klebsiella pneumoniae T2-1-1 from human oral cavity

    Directory of Open Access Journals (Sweden)

    Kok-Gan Chan

    2016-03-01

    Full Text Available Klebsiella pneumoniae T2-1-1 was isolated from the human tongue debris and subjected to whole genome sequencing on HiSeq platform and annotated on RAST. The nucleotide sequence of this genome was deposited into DDBJ/EMBL/GenBank under the accession JAQL00000000.

  5. 48 CFR 211.274-5 - Policy for assignment of Government-assigned serial numbers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Policy for assignment of... DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Using and Maintaining Requirements Documents 211.274-5 Policy for assignment of...

  6. 30 CFR 77.211-1 - Continuous methane monitoring device; installation and operation; automatic deenergization of...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Continuous methane monitoring device... Installations § 77.211-1 Continuous methane monitoring device; installation and operation; automatic deenergization of electric equipment. Continuous methane monitoring devices shall be set to...

  7. The clinical utility of a new tumor marker for lung cancer Cyfra 21-1

    International Nuclear Information System (INIS)

    Cytokeratins expressed in epithelial cells from respiratory epithelium are also expressed in situ by lung cancers. The Cyfra 21-1 assay is a newly developed test which measures in serum fragments of cytokeratin 19. The aim of our study was to asses the clinical utility of the protein as a marker for lung cancer. We evaluated this marker in 196 patients with lung cancer , 33 patients with being lung diseases and 60 healthy individuals. Significantly higher levels were observed in patients with lung cancer but there was not difference between histological types of lung cancer. Concentration of Cyfra 21-1 significantly correlated with the stage of disease and the highest levels were found in patients with metastases. Consequently the marker was significantly lower in patients who were operated upon when compared with unresectable ones p,0.0001. In addition we observed a correlation between Cyfra 21-1 concentration and survival time. Cyfra 21-1 as a tumor marker is clinically useful especially for NSCLC. (author)

  8. Cyfra 21-1 als Follow-up-Tumormarker bei Patienten mit Plattenepithelkarzinom des Oropharynx

    OpenAIRE

    Alkotyfa, Khaled

    2009-01-01

    Zusammenfassend kann festgestellt werden, dass die Erhebung der Cyfra 21-1- Konzentration im Serum wertvolle Hinweise vor allem hinsichtlich des Vorlegens von Fernmetastasen und Kontrolle des Therapieerfolges sowie des individuellen Krankheitsverlaufes geben kann. Die Resultate der vorliegenden Untersuchung zeigen, dass zum Zeitpunkt der Diagnosestellung keine eindeutige Korrelation zwischen dem Ausmaß der cervikalen Lymphknotenme...

  9. Whole genome analysis of Klebsiella pneumoniae T2-1-1 from human oral cavity.

    Science.gov (United States)

    Chan, Kok-Gan; Yin, Wai-Fong; Chan, Xin-Yue

    2016-03-01

    Klebsiella pneumoniae T2-1-1 was isolated from the human tongue debris and subjected to whole genome sequencing on HiSeq platform and annotated on RAST. The nucleotide sequence of this genome was deposited into DDBJ/EMBL/GenBank under the accession JAQL00000000. PMID:26981378

  10. 33 CFR 211.9 - Applications for leases, easements, licenses, and permits.

    Science.gov (United States)

    2010-07-01

    ... WITH CIVIL WORKS PROJECTS Temporary Use by Others of Civil Works Real Estate § 211.9 Applications for leases, easements, licenses, and permits. Applications for use of Civil Works property should be made to the District Engineer of the district within the boundaries of which the real estate is located....

  11. 20 CFR 10.211 - What are the employer's responsibilities in COP cases?

    Science.gov (United States)

    2010-04-01

    ...' COMPENSATION ACT, AS AMENDED Continuation of Pay Responsibilities § 10.211 What are the employer's responsibilities in COP cases? Once the employer learns of a traumatic injury sustained by an employee, it shall... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false What are the employer's responsibilities...

  12. 76 FR 2605 - Airworthiness Directives; Rolls-Royce plc RB211-Trent 800 Series Turbofan Engines

    Science.gov (United States)

    2011-01-14

    ... Register published on April 11, 2000 (65 FR 19477-78). Discussion The European Aviation Safety Agency (EASA... Order 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR... Directives; Rolls-Royce plc RB211-Trent 800 Series Turbofan Engines AGENCY: Federal Aviation...

  13. 75 FR 15321 - Airworthiness Directives; Rolls-Royce plc RB211-Trent 800 Series Turbofan Engines

    Science.gov (United States)

    2010-03-29

    ... Register on January 5, 2010 (75 FR 264). That NPRM proposed to correct an unsafe condition for the... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant...; AD 2010-06-14] RIN 2120-AA64 Airworthiness Directives; Rolls-Royce plc RB211-Trent 800...

  14. A study of the wiggle morphology of HH 211 through numerical simulations

    Science.gov (United States)

    Moraghan, Anthony; Lee, Chin-Fei; Huang, Po-Sheng; Vaidya, Bhargav

    2016-08-01

    Recent high-resolution, high-sensitivity observations of protostellar jets have shown many to possess deviations to their trajectories. HH 211 is one such example where sub-mm observations with the Submillimeter Array (SMA) have revealed a clear reflection-symmetric wiggle. The most likely explanation is that the HH 211 jet source could be moving as part of a protobinary system. Here, we test this assumption by simulating HH 211 through 3D hydrodynamic jet propagation simulations using the PLUTO code with a molecular chemistry and cooling module, and initial conditions based on an analytical model derived from SMA observations. Our results show the reflection-symmetric wiggle can be recreated through the assumption of a jet source perturbed by binary motion at its base, and that a regular sinusoidal velocity variation in the jet beam can be close to matching the observed knot pattern. However, a more complex model with either additional heating from the protostar, or a shorter period velocity pulsation may be required to account for enhanced emission near the source, and weaker knot emission downstream. Position-velocity diagrams along the pulsed jet beam show a complex structure with detectable signatures of knots and show caution must be exercised when interpreting radial velocity profiles through observations. Finally, we make predictions for future HH 211 observations with Atacama Large Millimeter Array.

  15. 25 CFR 211.47 - Diligence, drainage and prevention of waste.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Diligence, drainage and prevention of waste. 211.47..., drainage and prevention of waste. The lessee shall: (a) Exercise diligence in mining, drilling and... the prevention of waste of oil or gas or other minerals, the entrance of water through wells...

  16. Whole genome analysis of Klebsiella pneumoniae T2-1-1 from human oral cavity

    OpenAIRE

    Kok-Gan Chan; Wai-Fong Yin; Xin-Yue Chan

    2015-01-01

    Klebsiella pneumoniae T2-1-1 was isolated from the human tongue debris and subjected to whole genome sequencing on HiSeq platform and annotated on RAST. The nucleotide sequence of this genome was deposited into DDBJ/EMBL/GenBank under the accession JAQL00000000.

  17. 50 CFR 216.211 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE.... Gulf of Mexico § 216.211 Specified activity and specified geographical region. (a) Regulations in this... Mexico adjacent to the coasts of Texas, Mississippi, Louisiana, Alabama, and Florida. The incidental,...

  18. Improving Student Success in Principles of Accounting 211 with the Integration of Situational Leadership Methods.

    Science.gov (United States)

    Ewell, Paul L.

    2001-01-01

    Looks at the failure rate of students in Accounting 211 in the Virginia Community College System. States that rote teaching styles that do not incorporate interdisciplinary and other diverse methods, do not take into account developing learning skills, and do not encourage active learning are doomed to fail. Makes recommendations for new…

  19. 45 CFR 211.6 - Reception; temporary care, treatment, and assistance.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Reception; temporary care, treatment, and... SERVICES CARE AND TREATMENT OF MENTALLY ILL NATIONALS OF THE UNITED STATES, RETURNED FROM FOREIGN COUNTRIES § 211.6 Reception; temporary care, treatment, and assistance. (a) Reception. The agency will meet...

  20. X-ray Absorption Towards The Einstein Ring Source PKS1830-211

    CERN Document Server

    Mathur, S D; Mathur, Smita; Nair, Sunita

    1997-01-01

    PKS1830-211 is an unusually radio-loud gravitationally lensed quasar. In the radio, the system appears as two compact, dominant features surrounded by relatively extended radio emission which forms an Einstein Ring. As the line of sight to it passes close to our Galactic center, PKS1830-211 has not been detected in wave-bands other than the radio and X-ray so far. Here we present X-ray data of PKS1830-211 observed with ROSAT PSPC. The X-ray spectrum shows that absorption in excess of the Galactic contribution is highly likely, which at the redshift of the lensing galaxy ($z_l=0.886$) corresponds to N$_H=3.5^{+0.6}_{-0.5}\\times 10^{22}$ atoms cm$^{-2}$. The effective optical extinction is large, A$_V$(observed)\\gax5.8. When corrected for this additional extinction, the two point optical to X-ray slope \\aox\\ of PKS1830-211 lies just within the observed range of quasars. It is argued here that both compact images must be covered by the X-ray absorber(s) which we infer to be the lensing galaxy(galaxies). The dust...

  1. Whole genome analysis of Klebsiella pneumoniae T2-1-1 from human oral cavity.

    Science.gov (United States)

    Chan, Kok-Gan; Yin, Wai-Fong; Chan, Xin-Yue

    2016-03-01

    Klebsiella pneumoniae T2-1-1 was isolated from the human tongue debris and subjected to whole genome sequencing on HiSeq platform and annotated on RAST. The nucleotide sequence of this genome was deposited into DDBJ/EMBL/GenBank under the accession JAQL00000000.

  2. Herschel view of the Taurus B211/3 filament and striations: Evidence of filamentary growth?

    CERN Document Server

    Palmeirim, P; Kirk, J; Ward-Thompson, D; Arzoumanian, D; Könyves, V; Didelon, P; Schneider, N; Benedettini, M; Bontemps, S; Di Francesco, J; Elia, D; Griffin, M; Hennemann, M; Hill, T; Martin, P G; Men'shchikov, A; Molinari, S; Motte, F; Nutter, D; Peretto, N; Pezzuto, S; Roy, A; Rygl, K L J; Spinoglio, L; White, G

    2012-01-01

    We present first results from the Herschel Gould Belt survey for the B211/L1495 region in the Taurus molecular cloud. Thanks to their high sensitivity and dynamic range, the Herschel images reveal the structure of the dense, star-forming filament B211 with unprecedented detail, along with the presence of striations perpendicular to the filament and generally oriented along the magnetic field direction as traced by optical polarization vectors. Based on the column density and dust temperature maps derived from the Herschel data, we find that the radial density profile of the B211 filament approaches a power-law behavior {\\rho} {\\propto} r^(-2.0{\\pm}0.4) at large radii and that the temperature profile exhibits a marked drop at small radii. The observed density and temperature profiles of the B211 filament are in good agreement with a theoretical model of a cylindrical filament undergoing gravitational contraction with a polytropic equation of state: P {\\propto} {\\rho}^{\\gamma} and T {\\propto} {\\rho}^({\\gamma}-1...

  3. 42 CFR 137.211 - How does a Self-Governance Tribe learn whether self-governance activities have resulted in...

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false How does a Self-Governance Tribe learn whether self-governance activities have resulted in savings as described in § 137.210. 137.211 Section 137.211 Public... OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Operational Provisions Savings § 137.211 How...

  4. Clinical Usefulness of Serum CYFRA 21-1 in Patients with Colorectal Cancer

    International Nuclear Information System (INIS)

    Among diverse tumor markers, pretreatment evaluation and follow-up detection of recurrence in colorectal cancer are generally evaluated by serum carcinoembryonic antigen (CEA) levels. However, there have been some reports about the low accuracy and high false-positive results of CEA in colorectal cancer. We investigated the clinical utilities of CYFRA 21-1 by comparing CEA and cancer antigen 19-9 (CA 19-9) in pretreatment and recurrent colorectal cancer. Using a solid-phase immunoradiometric assay, serum levels of CYFRA 21-1, CEA and CA 19-9 were analyzed in 132 patients with primary colorectal cancer, 124 healthy controls, 104 patients with benign colorectal disease and 19 patients with recurrent colorectal cancer. We determined three different cutoff values to evaluate the sensitivity of diagnostic performance in pretreatment and recurrent colorectal cancer. CYFRA 21-1 (≥ 1.13 ng/ml) had a sensitivity of 47 %, compared with 37 % for CEA (≥ 3.05 ng/ml) and 32.6 % for CA 19-9 (≥ 23.1 ng/ml) in the initial staging of primary colorectal cancer. Using different cutoff values, CYFRA 21-1 showed higher sensitivity for pretreatment colorectal cancer than CEA and CA 19-9 in adenocarcinoma and adenosquamous carcinoma of this study. A mildly significant correlative relationship was noted between Dukes' stages and three tumor markers (p<0.01). The areas under the receiver operating characteristic curves of CYFRA 21-1, CEA and CA 19-9 were 0.81±0.03, 0.74±0.03 and 0.62 0.04, respectively, for discriminating colorectal cancer patients from patients with benign colorectal disease. In addition, CYFRA 21-1 was determined as the most sensitive tumor marker for evaluating recurrent colorectal cancer for all cutoff values. This study showed that CYFRA 21-1 could be a useful and dependable tumor marker for pretreatment and recurrent colorectal cancer. Further prospective studies on its usefulness with respect to the prognosis and utility of combined tumor markers are needed

  5. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven

  6. Clinical Usefulness of Serum CYFRA 21-1 in Patients with Colorectal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jai Hyuen [Dankook Univ. Medical College, Yongin (Korea, Republic of)

    2013-09-15

    Among diverse tumor markers, pretreatment evaluation and follow-up detection of recurrence in colorectal cancer are generally evaluated by serum carcinoembryonic antigen (CEA) levels. However, there have been some reports about the low accuracy and high false-positive results of CEA in colorectal cancer. We investigated the clinical utilities of CYFRA 21-1 by comparing CEA and cancer antigen 19-9 (CA 19-9) in pretreatment and recurrent colorectal cancer. Using a solid-phase immunoradiometric assay, serum levels of CYFRA 21-1, CEA and CA 19-9 were analyzed in 132 patients with primary colorectal cancer, 124 healthy controls, 104 patients with benign colorectal disease and 19 patients with recurrent colorectal cancer. We determined three different cutoff values to evaluate the sensitivity of diagnostic performance in pretreatment and recurrent colorectal cancer. CYFRA 21-1 (≥ 1.13 ng/ml) had a sensitivity of 47 %, compared with 37 % for CEA (≥ 3.05 ng/ml) and 32.6 % for CA 19-9 (≥ 23.1 ng/ml) in the initial staging of primary colorectal cancer. Using different cutoff values, CYFRA 21-1 showed higher sensitivity for pretreatment colorectal cancer than CEA and CA 19-9 in adenocarcinoma and adenosquamous carcinoma of this study. A mildly significant correlative relationship was noted between Dukes' stages and three tumor markers (p<0.01). The areas under the receiver operating characteristic curves of CYFRA 21-1, CEA and CA 19-9 were 0.81±0.03, 0.74±0.03 and 0.62±0.04, respectively, for discriminating colorectal cancer patients from patients with benign colorectal disease. In addition, CYFRA 21-1 was determined as the most sensitive tumor marker for evaluating recurrent colorectal cancer for all cutoff values. This study showed that CYFRA 21-1 could be a useful and dependable tumor marker for pretreatment and recurrent colorectal cancer. Further prospective studies on its usefulness with respect to the prognosis and utility of combined tumor markers are

  7. Hexavalent chromium removal and bioelectricity generation by Ochrobactrum sp. YC211 under different oxygen conditions.

    Science.gov (United States)

    Chen, Chih-Yu; Cheng, Chiu-Yu; Chen, Ching-Kuo; Hsieh, Min-Chi; Lin, Ssu-Ting; Ho, Kuo-Ying; Li, Jo-Wei; Lin, Chia-Pei; Chung, Ying-Chien

    2016-01-01

    Bioremediation is an environmentally friendly method of reducing heavy metal concentration and toxicity. A chromium-reducing bacterial strain, isolated from the vicinity of an electroplate factory, was identified as Ochrobactrum sp. YC211. The efficiency and capacity per time of Ochrobactrum sp. YC211 for hexavalent chromium (Cr(VI)) removal under anaerobic conditions were superior to those under aerobic conditions. An acceptable removal efficiency (96.5 ± 0.6%) corresponding to 30.2 ± 0.8 mg-Cr (g-dry cell weight-h)(-1) was achieved by Ochrobactrum sp. YC211 at 300 mg L(-1) Cr(VI). A temperature of 30°C and pH 7 were the optimal parameters for Cr(VI) removal. By examining reactivated cells, permeabilized cells, and cell-free extract, we determined that Cr(VI) removal by Ochrobactrum sp. YC211 under anaerobic conditions mainly occurred in the soluble fraction of the cell and can be regarded as an enzymatic reaction. The results also indicated that an Ochrobactrum sp. YC211 microbial fuel cell (MFC) with an anaerobic anode was considerably superior to that with an aerobic anode in bioelectricity generation and Cr(VI) removal. The maximum power density and Cr(VI) removal efficiency of the MFC were 445 ± 3.2 mW m(-2) and 97.2 ± 0.3%, respectively. Additionally, the effects of coexisting ions (Cu(2+), Zn(2+), Ni(2+), SO4(2-), and Cl(-)) in the anolyte on the MFC performance and Cr(VI) removal were nonsignificant (P > 0.05). To our knowledge, this is the first report to compare Cr(VI) removal by different cells and MFC types under aerobic and anaerobic conditions. PMID:26889692

  8. Fine-Needle Aspirate CYFRA 21-1, an Innovative New Marker for Diagnosis of Axillary Lymph Node Metastasis in Breast Cancer Patients

    OpenAIRE

    Choi, Ji Soo; Han, Kyung Hwa; Kim, Eun-Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Kim, Min Jung

    2015-01-01

    Abstract To compare the value of cytokeratin fragment 21-1 (CYFRA 21-1) concentration in the fine-needle biopsy aspirates (fine needle aspirate [FNA] CYFRA 21-1) with cytopathology of fine-needle aspiration biopsy (FNA cytology) and to assess whether CYFRA 21-1 concentrations from ultrasound-guided fine-needle aspiration biopsy (US-FNAB) specimens (FNA CYFRA 21-1) is not inferior to FNA cytology in the diagnosis of axillary lymph node (ALN) metastasis of breast cancer patients. This study rec...

  9. Keratin 19-positive cutaneous squamous cell carcinoma with elevated serum cytokeratin 19 fragment 21-1 level: A case report

    OpenAIRE

    UEDA, MISATO; YASUDA, MICHINORI; SHIBAOKA, YOSHIE; Kurokawa, Ichiro; Kakuno, Ayako; TSUBURA, AIRO

    2016-01-01

    cytokeratin 19 fragment 21-1 (CYFRA21-1) is a marker of lung cancer useful for evaluating clinical diagnosis and prognosis. To the best of our knowledge, there have been no reports of cutaneous squamous cell carcinoma (SCC) with high levels of CYFRA21-1 to date. We herein report a case of a 79-year-old man with a large subcutaneous tumor of the left shoulder, which was diagnosed as primary cutaneous poorly differentiated SCC. The tumor nests were composed of poorly differentiated atypical squ...

  10. Diagnosis Value of the Detection of CYFRA21-1 in Non-small Cell Lung Cancer

    OpenAIRE

    Gu, Jundong; Wang, Xinzhuo; Zhao, Hui; Zhu, Siwei; WEN, YANJUN; Hongrui XU; Li, Li; Chen, Jun; Zhou, Qinghua

    2010-01-01

    Background and objective Cytokeratin-19 fragment (CYFRA21-1) is a soluble protein in serum, and may be a useful circulating tumor marker. The aim of this study is to investigate the diagnostic value of the peripheral blood CYFRA21-1 in non-small cell lung cancer (NSCLC). Methods The levels of peripheral blood CYFRA21-1 were detected in 107 patients with NSCLC and 51 patients with benign pulmonary diseases by enzyme linked immunosorbent assay, and ROC curve was used to analyse the results. Res...

  11. ELECTRONIC PROPERTIES OF InSb(211)A,B SURFACES%InSb(211)A,B表面电子结构特性

    Institute of Scientific and Technical Information of China (English)

    贾瑜; 陈国剑; 马丙现; 胡行; 顾华伟; 李新建

    2000-01-01

    采用散射理论的格林函数方法计算了InSb(211)A,B两类表面的电子结构,分别给出了两类表面的表面投影能带结构,分析了各表面态的轨道特性和色散特性;并在此基础上讨论了两类表面的稳定性;计算结果和实验结果定性的相符合.

  12. Cyfra211DT、CEADT结合影像学早期诊断肺癌复发与转移%Cyfra211, Serum CEA Doubling Time and Early Diagnosis of Recurrence and Metastasis of Lung Cancer Imaging Dynamics

    Institute of Scientific and Technical Information of China (English)

    田荣华; 查云飞

    2013-01-01

    Objective To evaluate serum Cyfra211 ,CEA and their doubling time and imaging on recurrence and metastasis of lung cancer early diagnosis. Methods 152 cases of lung cancer patients,two years into three groups according to the condition, stable group 79 examples,recurrence in 31 cases of group, transfer group 42 cases. All objects half year 2-5 times serum Cy-fra211 determination,CEA,at the same time,CEADT Cyfra211DT calculation. The ROC Curve process ROC curves multivariable analysis,and with the single variable ROC curves for comparison,the track two years imaging findings,assessment Cyfra211 ,CEA and doubling time alone detection and four index united detection and imaging diagnosis lung cancer in dynamic changes the value of recurrence and metastasis. Results Cyfra211DT,CEADT in relapse and metastasis were the best for 136 days,the critical value of 153 days, 143 days, 132 days. Relapse and metastasis group Cyfra211,CEA and serum doubling time and stable group sensitivity and specificity were in significant differences. Conclusion Cyfra211DT and CEADT were better than Cyfra211 and serum CEA,four joint detection with imaging dynamic observation was helpful for early diagnosis of recurrence and metastasis.%目的 评价血清Cyfra211、CEA及其倍增时间与影像学动态变化对肺癌复发与转移的早期诊断价值.方法 152例肺癌患者,2年内按病情分为3组,稳定组79例,复发组31例,转移组42例.所有对象半年内2~5次测定血清Cyfra211、CEA,同时计算Cyfra211 DT、CEADT.采用ROC Curve过程进行多变量ROC曲线分析,并且与各单变量ROC曲线做比较,追踪两年内影像学表现,评价应用Cyfra211、CEA及其倍增时间单独检测和四指标联合检测以及影像学动态变化在诊断肺癌复发与转移中的价值.结果 Cyfra211 DT、CEADT在复发和转移中最佳临界值分别为136 d、153 d,143 d,132 d.复发和转移组血清Cyfra211、CEA及其倍增时间与稳定组中灵敏性和特异

  13. Clinical value of immunoradiometric assay Cyfra 21-1 in diagnosis of patients with lung cancer; Wartosc kliniczna immunoradiometrycznego badania Cyfra 21-1 w diagnozowaniu chorych na raka pluca

    Energy Technology Data Exchange (ETDEWEB)

    Cynowska, B.; Slominski, J.M.; Jassen, E.; Wyrwinski, J.; Skokowski, J.; Roszkiewicz, A. [Akademia Medyczna, Gdansk (Poland)

    1994-12-31

    Cyfra 21-1 is a new immunoradiometric assay which measure concentration of cytokeratin 19 fragments in serum. The serum levels of cytokeratin 19 were measured in 130 patients - 110 with lung cancer and 20 with non-malignant lung diseases. The reference group consisted of 60 healthy volunteers - 30 smokers and 30 non-smokers. Elevated Cyfra 21-1 values were observed mainly in NSCLC. There was not a correlation between cytokeratin 19 serum levels and histologic types of lung cancer. Cyfra 21-1 concentrations generally increased with stage of disease and the highest values were observed in patients with evidence of distant metastases. In SCLC, Cyfra 21-1 did not significantly differ between limited and extensive disease. (author). 12 refs, 1 tab.

  14. Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models

    International Nuclear Information System (INIS)

    We have evaluated SPECT and two planar imaging methods, geometric mean (GM) and buildup factor (BF), for their potential to quantitate in vivo 211At distributions in rat spinal subarachnoid spaces using phantom studies. The use of medium-energy collimators and the small diameter (3 mm) of the subarachnoid space complicate quantitation. Net activities from distributions in various backgrounds were obtained using a large region of interest with background subtraction. Results showed quantitation accuracy within 10% for SPECT and BF in low backgrounds increasing to 25% at higher background levels while GM errors ranged from 20 to 45%. We have also obtained images of [211At]astatide distributions, administered intrathecally, in rats

  15. Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library

    Science.gov (United States)

    Welford, Amanda J; Liu, Manjuan; Richards, Meirion; Brown, Nathan; Lomas, Cara; Tizzard, Graham J.; Pitak, Mateusz B.; Coles, Simon J.; Eccles, Suzanne A.; Raynaud, Florence I.; Collins, Ian

    2016-01-01

    Abstract The 2,11‐cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran‐based compounds designed to augment a typical medicinal chemistry library screen. Ring‐closing metathesis, lactonisation and SmI2‐mediated methods were exemplified and applied to the installation of a third ring to mimic the nine‐membered ring of the 2,11‐cembranoids. The library was assessed for aqueous solubility and permeability, with a chemical‐space analysis performed for comparison to the family of cembranoid natural products and a sample set of a screening library. Preliminary investigations in cancer cells showed that the simpler scaffolds could recapitulate the reported anti‐migratory activity of the natural products. PMID:26929153

  16. Electron transport and cyclotron resonance in (211)-oriented HgTe--CdTe superlattices

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, C.A.; Meyer, J.R.; Wagner, R.J.; Bartoli, F.J. (Naval Research Laboratory, Washington, D. C. 20375 (USA)); Chu, X.; Faurie, J.P. (University of Illinois at Chicago, Chicago, Illinois 60680 (USA)); Ram-Mohan, L.R.; Xie, H. (Worcester Polytechnic Institute, Worcester, Massachusetts 01609 (USA))

    1990-03-01

    We discuss a magnetotransport and magneto-optical investigation of (211)-oriented HgTe--CdTe superlattices. Measurements were performed on seven {ital n}-type samples with well widths in the range 41--125 A and energy gaps between 0 and 128 meV. Both magnetotransport and magneto-optical results give evidence for an additional electron species besides the superlattice electrons and holes usually observed. We show that although these have quasi-two-dimensional character, their mobilities are quite sensitive to the superlattice well thickness. These findings are interpreted in terms of band bending and charge transfer from the CdTe substrate into the superlattice. We also discuss the first theoretical calculations of the band structure for (211)-oriented HgTe--CdTe heterostructures.

  17. Differentialdiagnose beim Lungenkarzinom durch CEA, CYFRA 21-1, NSE und ProGRP

    OpenAIRE

    Gruber, Christine

    2008-01-01

    Es handelt sich um eine bizentrische, retrospektive Studie am Institut für Klinische Chemie am Klinikum Großhadern, München und an der Asklepioslungenfachklinik Gauting. Anhand von insgesamt 2749 Patienten wurde univariat und multivariat analysiert, inwieweit die Tumormarker CEA, CYFRA 21-1, NSE und ProGRP und zusätzlich die Routinelaborparameter eine Hilfestellung sowohl in der Diagnostik und Differentialdiagnostik eines Lungenrundherdes (benigne Lungenerkrankung, primäres Lungenkarzinom, Lu...

  18. Effect of 211At treating pollen and stigma on generative cells and seed setting of rice

    Institute of Scientific and Technical Information of China (English)

    JinJian-Nan; ChenFang; 等

    1998-01-01

    Low specific radioactivity (7.4kBq/ml) 211At treating pollen and stigma can obviously affect morphological structures and physiological functions of pollen,stigma and ovule or embryo sac cells,and cause injury.Results showed that because of the radiation effects the seed setting rate of rice was decreased,and the development of some embryos were affected and others became abnormal.

  19. 76 FR 65997 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-535 Series Turbofan Engines

    Science.gov (United States)

    2011-10-25

    ...-08, Amendment 39-16707 (76 FR 30529, May 26, 2011), and adding the following new AD: Rolls-Royce plc..., Amendment 39-16707 (76 FR 30529, May 26, 2011). (c) Applicability This AD applies to Rolls-Royce plc RB211... (76 FR 30529, May 26, 2011), for all RR RB211-535E4-37, -535E4-B-37, -535E4-B- 75, and...

  20. Structure, strain, and composition profiling of InAs/GaAs(211)B quantum dot superlattices

    International Nuclear Information System (INIS)

    The morphology, nanostructure, and strain properties of InAs quantum dots (QDs) grown on GaAs(211)B, uncapped or buried, are explored by transmission electron microscopy and related quantitative techniques. Besides the built-in piezoelectric field, other differences of (211) growth compared to (100)-oriented growth are discussed in terms of the (211) surface non-singularity, leading to anisotropic shape of the QDs and local chemical inhomogeneity of the wetting layer. The shape of the uncapped QDs was precisely defined as truncated pyramidal, elongated along the 〈111〉 direction, and bounded by the (110), (100), and (213) facets. Local strain measurements showed that large surface QDs were almost unstrained due to plastic relaxation, exhibiting small residual elastic strain at the interface that gradually diminished toward their apex. Conversely, buried QDs were pseudomorphically grown on GaAs. By postulating a plane stress state, we have established a systematic increase of the local strain from the base toward the apex region of the QDs. Using Vegard's law, their chemical composition profiles were calculated, revealing an indium content gradient along the growth direction and compositional variants among different QDs. Photoluminescence measurements showed variations in emission energy between the QDs and consistency with a graded In-content, which complied with the quantitative strain analysis

  1. Structure, strain, and composition profiling of InAs/GaAs(211)B quantum dot superlattices

    Science.gov (United States)

    Florini, N.; Dimitrakopulos, G. P.; Kioseoglou, J.; Germanis, S.; Katsidis, C.; Hatzopoulos, Z.; Pelekanos, N. T.; Kehagias, Th.

    2016-01-01

    The morphology, nanostructure, and strain properties of InAs quantum dots (QDs) grown on GaAs(211)B, uncapped or buried, are explored by transmission electron microscopy and related quantitative techniques. Besides the built-in piezoelectric field, other differences of (211) growth compared to (100)-oriented growth are discussed in terms of the (211) surface non-singularity, leading to anisotropic shape of the QDs and local chemical inhomogeneity of the wetting layer. The shape of the uncapped QDs was precisely defined as truncated pyramidal, elongated along the direction, and bounded by the {110}, {100}, and {213} facets. Local strain measurements showed that large surface QDs were almost unstrained due to plastic relaxation, exhibiting small residual elastic strain at the interface that gradually diminished toward their apex. Conversely, buried QDs were pseudomorphically grown on GaAs. By postulating a plane stress state, we have established a systematic increase of the local strain from the base toward the apex region of the QDs. Using Vegard's law, their chemical composition profiles were calculated, revealing an indium content gradient along the growth direction and compositional variants among different QDs. Photoluminescence measurements showed variations in emission energy between the QDs and consistency with a graded In-content, which complied with the quantitative strain analysis.

  2. The post-common-envelope, binary central star of the planetary nebula Hen 2-11

    Science.gov (United States)

    Jones, D.; Boffin, H. M. J.; Miszalski, B.; Wesson, R.; Corradi, R. L. M.; Tyndall, A. A.

    2014-02-01

    We present a detailed photometric study of the central star system of the planetary nebula Hen 2-11, selected for study because of its low-ionisation filaments and bipolar morphology - traits which have been strongly linked with central star binarity. Photometric monitoring with NTT-EFOSC2 reveals a highly irradiated, double-eclipsing, post-common-envelope system with a period of 0.609 d. Modelling of the lightcurve indicates that the nebular progenitor is extremely hot, while the secondary in the system is probably a K-type main sequence star. The chemical composition of the nebula is analysed, showing Hen 2-11 to be a medium-excitation non-Type i nebula. A simple photoionisation model is constructed determining abundance ratios of C/O and N/O which would be consistent with the common-envelope cutting short the AGB evolution of the nebular progenitor. The detection of a post-common-envelope binary system at the heart of Hen 2-11 further strengthens the link between binary progeny and the formation of axisymmetric planetary nebulae with patterns of low-ionisation filaments, clearly demonstrating their use as morphological indicators of central star binarity. Extracted 1D spectra, reduced 2D spectra, and table of photometry are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/562/A89

  3. The post-common-envelope, binary central star of the planetary nebula Hen 2-11

    CERN Document Server

    Jones, David; Miszalski, Brent; Wesson, Roger; Corradi, Romano L M; Tyndall, Amy A

    2014-01-01

    We present a detailed photometric study of the central star system of the planetary nebula Hen 2-11, selected for study because of its low-ionisation filaments and bipolar morphology - traits which have been strongly linked with central star binarity. Photometric monitoring with NTT-EFOSC2 reveals a highly irradiated, double-eclipsing, post-common-envelope system with a period of 0.609 d. Modelling of the lightcurve indicates that the nebular progenitor is extremely hot, while the secondary in the system is probably a K-type main sequence star. The chemical composition of the nebula is analysed, showing Hen 2-11 to be a medium-excitation non-Type I nebula. A simple photoionisation model is constructed determining abundance ratios of C/O and N/O which would be consistent with the common-envelope cutting short the AGB evolution of the nebular progenitor. The detection of a post-common-envelope binary system at the heart of Hen 2-11 further strengthens the link between binary progeny and the formation of axisymm...

  4. A study of the wiggle morphology of HH 211 through numerical simulations

    CERN Document Server

    Moraghan, Anthony; Huang, Po-Sheng; Vaidya, Bhargav

    2016-01-01

    Recent high-resolution high-sensitivity observations of protostellar jets have shown many to possess deviations to their trajectories. HH 211 is one such example where sub-mm observations with the SMA have revealed a clear reflection-symmetric wiggle. The most likely explanation is that the HH 211 jet source could be moving as part of a protobinary system. Here we test this assumption by simulating HH 211 through 3D hydrodynamic jet propagation simulations using the PLUTO code with a molecular chemistry and cooling module, and initial conditions based on an analytical model derived from SMA observations. Our results show the reflection-symmetric wiggle can be recreated through the assumption of a jet source perturbed by binary motion at its base, and that a regular sinusoidal velocity variation in the jet beam can be close to matching the observed knot pattern. However, a more complex model with either additional heating from the protostar, or a shorter period velocity pulsation may be required to account for...

  5. Discovery of a new TeV gamma-ray source: VER J0521+211

    CERN Document Server

    Archambault, S; Aune, T; Beilicke, M; Benbow, W; Bird, R; Bouvier, A; Buckley, J H; Bugaev, V; Byrum, K; Cesarini, A; Ciupik, L; Connolly, M P; Cui, W; Errando, M; Falcone, A; Federici, S; Feng, Q; Finley, J P; Fortson, L; Furniss, A; Galante, N; Gall, D; Gillanders, G H; Griffin, S; Grube, J; Gyuk, G; Hanna, D; Holder, J; Hughes, G; Humensky, T B; Kaaret, P; Kertzman, M; Khassen, Y; Kieda, D; Krawczynski, H; Krennrich, F; Kumar, S; Lang, M J; Madhavan, A S; Maier, G; Majumdar, P; McArthur, S; McCann, A; Millis, J; Moriarty, P; Mukherjee, R; de Bhroithe, A O'Faolain; Ong, R A; Otte, A N; Park, N; Perkins, J S; Pohl, M; Popkow, A; Prokoph, H; Quinn, J; Ragan, K; Reyes, L C; Reynolds, P T; Richards, G T; Roache, E; Saxon, D B; Sembroski, G H; Smith, A W; Staszak, D; Telezhinsky, I; Theiling, M; Varlotta, A; Vassiliev, V V; Vincent, S; Wakely, S P; Weekes, T C; Weinstein, A; Welsing, R; Williams, D A; Zitzer, B; Bottcher, M; Fegan, S J; Fortin, P; Halpern, J P; Kovalev, Y Y; Lister, M L; Liu, J; Pushkarev, A B; Smith, P S

    2013-01-01

    We report the detection of a new TeV gamma-ray source, VER J0521+211, based on observations made with the VERITAS imaging atmospheric Cherenkov telescope array. These observations were motivated by the discovery of a cluster of >30GeV photons in the first year of Fermi-LAT observations. VER J0521+211 is relatively bright at TeV energies, with a mean photon flux of 1.93 +/- 0.13_stat +/- 0.78_sys 10^-11 cm-2 s-1 above 0.2 TeV during the period of the VERITAS observations. The source is strongly variable on a daily timescale across all wavebands, from optical to TeV, with a peak flux corresponding to ~0.3 times the steady Crab Nebula flux at TeV energies. Follow-up observations in the optical and X-ray bands classify the newly-discovered TeV source as a BL Lac-type blazar with uncertain redshift, although recent measurements suggest z=0.108. VER J0521+211 exhibits all the defining properties of blazars in radio, optical, X-ray, and gamma-ray wavelengths.

  6. Structure, strain, and composition profiling of InAs/GaAs(211)B quantum dot superlattices

    Energy Technology Data Exchange (ETDEWEB)

    Florini, N.; Dimitrakopulos, G. P.; Kioseoglou, J.; Kehagias, Th., E-mail: kehagias@auth.gr [Physics Department, Aristotle University of Thessaloniki, 54624 Thessaloniki (Greece); Germanis, S.; Pelekanos, N. T. [Department of Materials Science and Technology, University of Crete, P.O. Box 2208, 70013 Heraklion (Greece); Microelectronics Research Group, IESL-FORTH, P.O. Box 1385, 71110 Heraklion (Greece); Katsidis, C. [Department of Materials Science and Technology, University of Crete, P.O. Box 2208, 70013 Heraklion (Greece); Hatzopoulos, Z. [Microelectronics Research Group, IESL-FORTH, P.O. Box 1385, 71110 Heraklion (Greece); Department of Physics, University of Crete, P.O. Box 2208, 70013 Heraklion (Greece)

    2016-01-21

    The morphology, nanostructure, and strain properties of InAs quantum dots (QDs) grown on GaAs(211)B, uncapped or buried, are explored by transmission electron microscopy and related quantitative techniques. Besides the built-in piezoelectric field, other differences of (211) growth compared to (100)-oriented growth are discussed in terms of the (211) surface non-singularity, leading to anisotropic shape of the QDs and local chemical inhomogeneity of the wetting layer. The shape of the uncapped QDs was precisely defined as truncated pyramidal, elongated along the 〈111〉 direction, and bounded by the (110), (100), and (213) facets. Local strain measurements showed that large surface QDs were almost unstrained due to plastic relaxation, exhibiting small residual elastic strain at the interface that gradually diminished toward their apex. Conversely, buried QDs were pseudomorphically grown on GaAs. By postulating a plane stress state, we have established a systematic increase of the local strain from the base toward the apex region of the QDs. Using Vegard's law, their chemical composition profiles were calculated, revealing an indium content gradient along the growth direction and compositional variants among different QDs. Photoluminescence measurements showed variations in emission energy between the QDs and consistency with a graded In-content, which complied with the quantitative strain analysis.

  7. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  8. 尿液CYFRA21-1诊断膀胱癌的Meta分析%Meta analysis of urine CYFRA21-1 in diagnosis of bladder carcinoma

    Institute of Scientific and Technical Information of China (English)

    夏勇; 龙嘉杰; 郭旭光

    2014-01-01

    目的:对尿液细胞角蛋白19-片段(CYFRA21-1)诊断膀胱癌的准确性进行系统评价。方法检索1990~2013年间国外公开发表的关于CYFRA21-1诊断膀胱癌的文献,对纳入的文献进行质量评价并进行Meta分析。结果共有11篇文献纳入,纳入研究对象3395例。CYFRA21-1并发的敏感度和特异性为71%和75%,拟合CYFRA21-1的SROC曲线下面积AUC为0.9082。结论尿液CYFRA21-1在诊断膀胱癌时有较好的准确性,可以作为膀胱癌诊断的辅助检查。%Objective To evaluate the accuracy of diagnostic test of urine CYFRA 21-1 for bladder carcinoma . Methods All the published clinical studies that evaluated the diagnostic value of CYFRA 21-1 in bladder carcinoma from 1990 to 2013 were analyzed .The quality of the tudies which were included evaluated according to the require-ments of Meta-analysis .All the eligible studies will be analyzed by the Meta-analysis .Results Eleven studies were collected and the sample size was 3395 cases .The pooled sensitivity [95% confidence interval (CI)] was 71% (68%to 73% )and the pooled specificity [95% confidence interval (CI)] of CYFRA21-1 was 75% (73% to 77% ) .And the area under SROC (AUC) of CYFRA21-1 was 0 .908 2 .Conclusion CYFRA21-1 is suitiable for the diagnosis of bladder carcinoma .

  9. Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma.

    Science.gov (United States)

    Malhotra, Rewa; Urs, Aadithya B; Chakravarti, Anita; Kumar, Suman; Gupta, V K; Mahajan, Bhawna

    2016-07-01

    Oral squamous cell carcinoma (OSCC) accounts for 90 % of malignant lesions of oral cavity. The study assessed the potential of Cyfra 21-1 as a tumor marker in OSCC. The study included 50 patients of OSCC to evaluate levels of Cyfra 21-1 in serum and saliva by electrochemiluminescent immunoassay (ECLIA) and CK19 messenger RNA (mRNA) expression in tissue by florescent quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR) along with healthy individuals as control. The salivary and serum Cyfra 21-1 levels in patients of OSCC were significantly higher compared to controls (p value Cyfra 21-1, serum Cyfra 21-1, and CK19 mRNA expression and between salivary Cyfra 21-1 and CK19 mRNA expression. Among these, correlation between serum and salivary Cyfra 21-1 was highly significant. Salivary and serum Cyfra 21-1 showed significantly elevated levels in grade II OSCC compared to grade I histopathologically. Elevated levels of salivary Cyfra 21-1 were associated with recurrence in OSCC patients. Reverse operating curve constructed using 3 ng/ml as a cutoff for serum Cyfra 21-1 revealed the sensitivity and specificity to be 88 and 78.2 %, respectively. Using a cutoff value of 8.5 ng/ml for salivary Cyfra 21-1, the sensitivity was found to be 93.8 % and specificity 84.3 %. We advocate salivary Cyfra 21-1 as a better diagnostic marker over serum Cyfra 21-1 as well as a potential marker in the prognosis of OSCC. PMID:26779624

  10. Correlation between Changes in Serum Level of CEA and CYFRA 21-1 and Objective Response of Chemotherapy

    Directory of Open Access Journals (Sweden)

    Xinlin MU

    2009-09-01

    Full Text Available Background and objective Serum levels of tumor markers are associated with tumor metabolism or apoptosis, changes of which after chemotherapy may reflect tumor response to treatment. The aim of this study was to assess the predictive role of changes in serum levels of carcinoembryonic antigen (CEA and cytokeratin 19 fragment (CYFRA 21-1 during chemotherapy in patients with advanced non-small cell lung cancer. Methods Changes in serum levels of CEA and CYFRA 21-1 were investigated retrospectively after one cycle of chemotherapy in 42 patients with advanced NSCLC. Correlations between the changes and radiological objective response were analyzed. Results After two cycles of chemotherapy, radiological objective response rate was 28.6%. At baseline, gender, age, clinical stage, serum levels of CEA and CYFRA 21-1 were not different between patients with objective response (OR and no response (NR. After one cycle of chemotherapy, compared to baseline level, declines in serum levels of CEA and CYFRA 21-1 were observed in patients with OR, but have no statistical significance. In contrast, reduction of CEA and CYFRA 21-1 over baseline after one cycle of chemotherapy showed statistically significant difference between OR and NR. When reduction percentages of CEA and CYFRA 21-1 were used to predict objective response of chemotherapy, the area under the ROC curve (AUC was 0.875 for CEA and 0.919 for CYFRA 21-1. According to the ROC curve, a 22% reduction of CEA yielded a sensitivity of 58.3% and a specificity of 97%, 51% reduction of CYFRA 21-1 with a sensitivity of 83.3% and a specificity of 93.3%. When above reduction percentages were used as cutoffs for prediction of radiological objective response, combination of the CEA and CYFRA 21-1 yielded a sensitivity of 91.7% and a specificity of 86.7%. Conclusion Reduction percentages of CEA and CYFRA 21-1 during chemotherapy could be used to evaluate chemotherapy efficacy in patients with advanced NSCLC. The

  11. 肺鳞癌CEA及CYFRA 21-1和NSE检测的临床意义%Clinical significance of detection of carcinoembryonic antigen, CYFRA 21-1, and neuron-specific enolase in lung squamous cell cancer patients

    Institute of Scientific and Technical Information of China (English)

    崔永; 龚民; 常栋; 吕可洁; 王天佑

    2008-01-01

    目的 研究癌胚抗原(CEA)、细胞角质蛋白(CYFRA21-1)和神经元特异性烯醇化酶(NSE)在肺鳞状细胞癌(SQC)患者血清中的水平与患者TNM分期、可否行手术治疗及预后之间的关系.方法 检测210例SQC患者的血清标本(Ⅰ期20例、Ⅱ期27例、ⅢA期55例、ⅢB期80例、Ⅳ期28例)CEA、CYFRA 21-1和NSE的血清水平.NSE和CYFRA21-1采用放免测定,CEA采用化学发光法测定.结果 CYFRA 21-1升高最为常见.CEA和CYFRA 21-1与TNM分期相关,而NSE与TNM分期无关.CEA和CYFRA 21-1血清水平均值与可手术(1、Ⅱ、ⅢA)和不可手术(ⅢB、Ⅳ期)有相关性(P<0.001).NSE血清水平均值与可否手术差异无显著性.结论 治疗前CYFRA 21-1和NSE的血清浓度与预后有关,可作为SQC患者可否手术的参考指标,并可为SQC预后判断提供重要信息.

  12. IR211X系列驱动器的应用试析%The Application Discussion of The IR211X Series Driver Circuit

    Institute of Scientific and Technical Information of China (English)

    陈昊

    2013-01-01

    IR211X系列是高压,高速功率MOSFET和IGBT驱动器,具有两个独立的高、低输出通道.它采用高度集成的电平转换技术,大大简化了逻辑电路对功率器件的控制要求,同时提高了驱动电路的可靠性.文中介绍了该系列芯片的主要功能及技术参数,并就应用中注意事项进行了分析并给出了相应解决措施.

  13. DNA damage in lymphocytes after irradiation with 211At and 188Re. Quantification by alkaline and neutral comet assay

    International Nuclear Information System (INIS)

    Aim: Ionising radiation produces many types of DNA lesions of different complexity. High linear energy transfer (LET) types of radiation are biological more effective than low LET radiation. In the present work we applied the single cell gel electrophoreses (comet assay) to study the induction of initial DNA damage, efficiency of repair and residual DNA damage in lymphocytes after treatment with 211At and 188Re. Methods: Peripheral blood mononuclear cells (PBMC) were isolated from heparinized blood of healthy donors and irradiated with 211At and 188Re at different doses. The comet assay was performed under alkaline and neutral conditions in order to detect the initial DNA damage and its repair. The measure of damage was% tail DNA (percentage of DNA in the tail). Results: After treatment of cells with 188Re the initial DNA damage (% tail DNA) detected with the alkaline comet assay was higher than the damage measured for 21lAt. The neutral comet assay estimated higher tail intensities for 211At in contrast to 188Re. Compared with the complete repair (10%) after irradiation with 188Re, the radiotoxicity of alpha particles indicated reduced rejoining of DNA strand breaks (60-80% residual damage). Rejoining of DNA damage measured by the neutral comet method detected about 70% unrepaired strand breaks for 211At and 188Re. Conclusions: There are major differences between the repair of strand breaks caused by 188Re and 211At detected by the alkaline comet assay. The DNA-damage induced by the high LET Emitter 211At remains nearly unrepaired detected by both alkaline and neutral comet assay. Represented data following irradiation of lymphocytes with alpha and beta particles demonstrated higher biological effectiveness of 211At by factors of 2.0-2.5. (orig.)

  14. Comparison of CYFRA 21-1, CEA, CA 19-9 and CA 72-4 levels in gastric cancer

    Directory of Open Access Journals (Sweden)

    Gökhan Çakırca

    2013-01-01

    Full Text Available Objective: Gastric cancer is the fourth most common malignancy,and the second most common cause of cancermortality worldwide. The aim of this study was to investigatethe role of biomarkers CYFRA 21-1, CA 19-9, CEA,CA72.4 at diagnosis and throughout the follow-up in patientswith gastric cancer.Methods: 30 patients with gastric cancer diagnosed and31 healthy people as a control group were included in thisstudy. According to the TNM staging system, there were16 patients with stage II and 14 patients with stage III inthe group of patients with gastric cancer. CEA, CA 19-9,CA 72-4 and CYFRA 21-1 levels were studied by elektrochemiluminescenceimmunasay (ECLIA method in theCobas e 601 instrument.Results: Statistically the level of CA 72-4, CA 19-9, CEAand CYFRA 21-1 gastric cancer groups was found significanthigh accaording to healthy control group (p<0.01.Statistically compared with II stage patient group, the levelof CA 19-9, CEA and CYFRA 21-1 of III stage patientgroup was found significant high (p<0.01. The diagnosticcut-off, sensitivity and specificity for CEA were 4.15 ng/mL, 46 % and 96%, respectively; for CA 19-9 were 24.50U/mL, 17 % and 96 %; for CA 72-4 were 2.46 U/mL, 53% and 96% and for CYFRA 21-1 were 3.36 ng/mL, 46%and 100%.Conclusion: Our study demonstrates that the associationof biomarkers CYFRA 21-1, CEA, and CA72.4 providesa valuable contribution in the follow-up of gastriccancer patients.Key words: Gastric cancer, tumor markers, CYFRA 21-1

  15. Diagnostic accuracy of cytokeratin-19 fragment (CYFRA 21-1) for bladder cancer: a systematic review and meta-analysis.

    Science.gov (United States)

    Huang, Yuan-Lan; Chen, Jie; Yan, Wei; Zang, Ding; Qin, Qin; Deng, An-Mei

    2015-05-01

    Previous studies have evaluated the accuracy of serum and urinary measurements of cytokeratin-19 fragment (CYFRA 21-1) for the diagnosis of bladder cancer; however, the results have been inconsistent. The aim of this study was to evaluate the overall accuracy of CYFRA 21-1 for the diagnosis of bladder cancer. We performed a search for English-language publications reporting on the detection of CYFRA21-1 levels for the diagnosis of bladder cancer through November 2, 2014, using public medical databases, including EMBASE, Web of Science, and Medline. The quality of the studies was assessed by revised QUADAS tools. The performance characteristics were pooled and analyzed using a bivariate model. Publication bias was explored with the Deek's test. Sixteen studies, with a total 1,262 bladder-cancer patients and 1,233 non-bladder-cancer patients, were included in the study. The pooled sensitivities for serum and urine CYFRA 21-1 were 0.42 (95 % confidence interval (CI), 0.33-0.51) and 0.82 (95 % CI, 0.70-0.90), respectively. The corresponding specificities were 0.94 (95 % CI, 0.90-0.96) and 0.80 (95 % CI, 0.73-0.86), respectively. The areas under the summary receiver-operating-characteristic curves for serum and urine CYFRA 21-1 were 0.88 (95 % CI, 0.85-0.91) and 0.87 (95 % CI, 0.84-0.90), respectively. The major design deficiencies of the included studies were participant-selection bias, potential review, and verification bias. Therefore, we concluded that both serum and urine CYFRA 21-1 served as efficient indexes for bladder-cancer diagnosis. Additional, well-designed studies should be performed to rigorously evaluate the diagnostic value of CYFRA 21-1 for bladder cancer. PMID:25854170

  16. Detection of serum CYFRA21-1 in patients with urothelial bladder carci-noma%膀胱尿路上皮细胞癌患者血清 CYFRA21-1水平的测定

    Institute of Scientific and Technical Information of China (English)

    孔朝辉; 朱晓博; 范小玲

    2014-01-01

    目的:检测膀胱尿路上皮细胞癌患者血清中CYFRA21-1水平并探讨其临床意义。方法:采用电化学发光免疫分析技术检测57例膀胱尿路上皮细胞癌患者和52例泌尿系统良性疾病患者以及49例健康个体血清CY-FRA21-1水平。结果:膀胱尿路上皮细胞癌患者血清CYFRA21-1水平和阳性率均高于泌尿系统良性疾病患者与健康人群( F/χ2=28.949、15.221,P均<0.05)。膀胱尿路上皮细胞癌病理分级与血清CYFRA21-1水平及阳性率均无关(P均>0.05)。 T3及T3M+期肿瘤较Ta、T1、T2期肿瘤患者血清CYFRA21-1水平及阳性率均升高(F/χ2=2.096、34.232,P均<0.05);与初发肿瘤相比,复发膀胱尿路上皮细胞癌患者血清CYFRA21-1水平及阳性率均升高(t/χ2=3.968、9.541,P均<0.05)。结论:血清CYFRA21-1可以作为膀胱尿路上皮细胞癌的一个可靠的肿瘤标志物,特别是在监测膀胱尿路上皮癌转移或复发时更具优势。%Aim:To study value of serum CYFRA21-1 in urothelial bladder carcinoma and its clinical significance . Methods:Electrochemiluminescence method was used to detect serum CYFRA 21-1 level of 158 patients, including 57 ca-ses with urothelial bladder carcinoma (group 1), 52 cases with benign diseases of the urinary system (group 2), and 49 healthy individuals(group 3).Results: Compared with group 2 and group 3, serum CYFRA21-1 level and positive rate were significantly higher in group 1 (F/χ2 =28.949,15.221,P0.05).The CYFRA21-1 level and positive rate increased significantly in T 3 and T3M+stage compared to Ta, T1 and T2 stage(F/χ2 =2.096,34.232,P<0.05).Compared with primary tumor, serum CYFRA21-1 level and positive rate were significantly increased in recurrent urothelial bladder carcinoma ( t/χ2 =3.968, 9.541,P<0.05).Conclusion:Serum CYFRA21-1 seems to be a marker of urothelial bladder carcinoma .It is useful for monitoring this disease

  17. Clinical analysis of hydroxyapatite orbital implantation after ocular trauma in 211 cases

    Institute of Scientific and Technical Information of China (English)

    LIANG Tao; ZHAO Gui-qiu; MENG Xu-xia; ZHANG Ling-yun

    2006-01-01

    Objective: To evaluate the therapeutic effects and complications of hydroxyapatite (HA) orbital implantation on patients after trauma-related surgeries.Methods: Retrospective analysis was made from 211 cases (211 eyes ) who underwent HA orbital implant placement after trauma-related enucleation or evisceration,including 68 cases of evisceration and primary HA implant placement, 77 cases of enucleation and HA implant placement wrapped with multi-windowed sclera, 66 cases of enucleation and HA implant placement free of wrapping.All the cases were followed up for 1-5 years to observe the therapeutic effects and major complications.Results: Five of 211 cases had wound dehiscence.Ten cases had HA implants exposure, including 1 case suffering severe orbital infection and requiring HA implant removal. The implants exposure incidences by the three surgical methods were from 1.30% to 10.06% and averaged 4.74%. Significant difference was found in late exposure incidence and total incidence from the three methods ( χ2 = 13.372, P < 0.01 and χ2 = 7.540, P < 0.05).Two cases had shrinkage of the lower fornix. Enophthalmos occurred in 1 case treated by method 1 and was corrected by implanting porous polyethylene (Medpor) plate into the bottom of orbit. In 210 cases, the artificial eye moved well and the cosmetic results were satisfactory.Conclusions: Different surgical methods have their own merit and disadvantage. Enucleation and placement of HA implant wrapped with multi-windowed sclera has corroborated fewer complications than others.

  18. Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities.

    Science.gov (United States)

    Brunetti-Pierri, Nicola; Berg, Jonathan S; Scaglia, Fernando; Belmont, John; Bacino, Carlos A; Sahoo, Trilochan; Lalani, Seema R; Graham, Brett; Lee, Brendan; Shinawi, Marwan; Shen, Joseph; Kang, Sung-Hae L; Pursley, Amber; Lotze, Timothy; Kennedy, Gail; Lansky-Shafer, Susan; Weaver, Christine; Roeder, Elizabeth R; Grebe, Theresa A; Arnold, Georgianne L; Hutchison, Terry; Reimschisel, Tyler; Amato, Stephen; Geragthy, Michael T; Innis, Jeffrey W; Obersztyn, Ewa; Nowakowska, Beata; Rosengren, Sally S; Bader, Patricia I; Grange, Dorothy K; Naqvi, Sayed; Garnica, Adolfo D; Bernes, Saunder M; Fong, Chin-To; Summers, Anne; Walters, W David; Lupski, James R; Stankiewicz, Pawel; Cheung, Sau Wai; Patel, Ankita

    2008-12-01

    Chromosome region 1q21.1 contains extensive and complex low-copy repeats, and copy number variants (CNVs) in this region have recently been reported in association with congenital heart defects, developmental delay, schizophrenia and related psychoses. We describe 21 probands with the 1q21.1 microdeletion and 15 probands with the 1q21.1 microduplication. These CNVs were inherited in most of the cases in which parental studies were available. Consistent and statistically significant features of microcephaly and macrocephaly were found in individuals with microdeletion and microduplication, respectively. Notably, a paralog of the HYDIN gene located on 16q22.2 and implicated in autosomal recessive hydrocephalus was inserted into the 1q21.1 region during the evolution of Homo sapiens; we found this locus to be deleted or duplicated in the individuals we studied, making it a probable candidate for the head size abnormalities observed. We propose that recurrent reciprocal microdeletions and microduplications within 1q21.1 represent previously unknown genomic disorders characterized by abnormal head size along with a spectrum of developmental delay, neuropsychiatric abnormalities, dysmorphic features and congenital anomalies. These phenotypes are subject to incomplete penetrance and variable expressivity.

  19. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  20. Effects of Y211 phase contents on the critical current density Jc and microstructural analysis in YBCO bulk superconductors

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    YBCO bulk superconductors were prepared by the solid state reaction and top-seed-melt-textured growth (TSMTG) process. By using the AC susceptibility measurement, the critical transition temperature Tc of samples is 91.5 K for the highest value, and the transition width ?Tc is less than 1 K. The highest magnetization critical current densities Jc achieved 106 A/cm2 under 5 T at 10 K and 1.35?104 A/cm2 under 2 T at 70 K (H//c), respectively. The results combining the SEM observation indicate that doping of Y211 particles is more effective in improving the growth quality of melt-textured YBCO superconductor and in reducing the micro-cracks of specimens. Doping of Y2O3 powder forms the rod-shaped Y211 particles, but doping of Y211 particles directly to matrix materials forms the spherical Y211 particles mainly. Combining the microstructures with Jc measurements shows that the interfaces are most important on flux bundle pinning, in which the gradient of free energy is larger than that of other place between the Y211 particles and the Y123 matrix materials.

  1. Functional design criteria, Project W-211, Initial Tank Retrieval Systems. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Rieck, C.A.

    1995-02-07

    This document provides the technical baseline for retrieval of waste from ten double-shell tanks in the SY, AN, AP, AW, AY, and AZ tank farms. In order to retrieve waste from these tanks, systems are needed to mix the sludge with the supernate and pump the waste mixture from the tank. For 101-SY, the existing mitigation pump will be used to mix the waste and Project W-211 will provide for waste removal. The retrieval scope for the other nine tanks includes both the waste mixing and removal functions.

  2. Update on the 2+1+1 flavor QCD equation of state with HISQ

    CERN Document Server

    Bazavov, A; DeTar, C; Foley, J; Gottlieb, Steven; Heller, U M; Hetrick, J E; Laiho, J; Levkova, L; Osborn, J; Sugar, R; Toussaint, D; Van de Water, R S; Zhou, R

    2013-01-01

    We present recent results on the QCD equation of state with 2+1+1 flavors of highly improved staggered quarks (HISQ). We focus on three sets of ensembles with temporal extent 6, 8 and 10, that reach up to temperatures of 967, 725 and 580 MeV, respectively. The strange and charm quark masses are tuned to the physical values and the light quarks mass is set to one fifth of the strange. This corresponds to a Goldstone pion of about 300 MeV.

  3. Light hadrons from Nf=2+1+1 dynamical twisted mass fermions

    CERN Document Server

    Baron, R; Boucaud, P; Carbonell, J; Deuzeman, A; Drach, V; Farchioni, F; Gimenez, V; Herdoiza, G; Jansen, K; Michael, C; Montvay, I; Pallante, E; Pène, O; Reker, S; Urbach, C; Wagner, M; Wenger, U

    2010-01-01

    We present results of lattice QCD simulations with mass-degenerate up and down and mass-split strange and charm (Nf=2+1+1) dynamical quarks using Wilson twisted mass fermions at maximal twist. The tuning of the strange and charm quark masses is performed at three values of the lattice spacing a~0.06 fm, a~0.08 fm and a~0.09 fm with lattice sizes ranging from L~1.9 fm to L~3.9 fm. We perform a preliminary study of SU(2) chiral perturbation theory by combining our lattice data from these three values of the lattice spacing.

  4. Status of ETMC simulations with Nf=2+1+1 twisted mass fermions

    CERN Document Server

    Baron, R; Deuzeman, A; Drach, V; Farchioni, F; Giménez, V; Herdoiza, G; Jansen, K; Montvay, I; Palao, D; Pallante, E; Pène, O; Reker, S; Scholz, E E; Urbach, C; Wagner, M; Wenger, U

    2008-01-01

    We present the status of runs performed in the twisted mass formalism with $N_{\\rm f}=2+1+1$ flavours of dynamical fermions: a degenerate light doublet and a mass split heavy doublet. The procedure for tuning to maximal twist will be described as well as the current status of the runs using both thin and stout links. Preliminary results for a few observables obtained on ensembles at maximal twist will be given. Finally, a reweighting procedure to tune to maximal twist will be described.

  5. Low lying baryon spectrum with Nf=2+1+1 dynamical twisted quarks

    International Nuclear Information System (INIS)

    We present first results on the octet and decuplet strange baryon spectrum with Nf=2+1+1 twisted mass quarks. We use an Osterwalder Seiler valence strange quark with a mass tuned to the kaon and compare the results with those obtained in the unitary setup. This comparison allows to perform a first study of the lattice artefacts introduced by the mixed action approach. We investigate the effect of the strange and charm quarks in the sea by using two lattice spacings and comparing with preceding Nf=2 twisted mass fermion calculations. (orig.)

  6. Detection of extragalactic CF+ toward PKS1830-211 -- Chemical differentiation in the absorbing gas

    CERN Document Server

    Muller, S; Black, J H; Amano, T

    2016-01-01

    We report the first extragalactic detection of CF+, the fluoromethylidynium ion, in the z=0.89 absorber toward PKS1830-211. We estimate an abundance of ~3E-10 relative to H2 and that ~1% of fluorine is captured in CF+. The absorption line profile of CF+ is found to be markedly different from that of other species observed within the same tuning, and is notably anti-correlated with CH3OH. On the other hand, the CF+ profile resembles that of [C I]. Our results are consistent with expected fluorine chemistry and point to chemical differentiation in the column of absorbing gas.

  7. Yeast Interacting Proteins Database: YLR446W, YLR211C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YLR446W - Putative protein of unknown function with similarity to hexokinases; tran...script is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene... Rows with this bait as bait (2) Rows with this bait as prey (0) YLR211C - Putative protein of unknown funct...ion; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR...as bait (0) 3 4 3 4 0 0 0 0 0 - - - - - 0 0 6 - Show YLR446W Bait ORF YLR446W Bait gene name - Bait descript

  8. Spectroscopy of high spin states in sup(211,212,213)Fr

    International Nuclear Information System (INIS)

    The level structures of 211Fr, 212Fr and 213Fr have been observed to high spins, approx. 28(h/2π) (and excitation energies approx. 8 MeV) using a variety of gamma-ray spectroscopic techniques. The structure of these nuclides is discussed in terms of couplings of single particle states through empirical shell model calculations. Good agreement with experiment is obtained. In 212Fr and 213Fr core-excited configurations are required to explain the properties of the highest states. A number of long lived states were observed in each nucleus some of which decay by by enhanced E3 transitions. The E3 transition strengths are discussed

  9. Low lying baryon spectrum with N{sub f}=2+1+1 dynamical twisted quarks

    Energy Technology Data Exchange (ETDEWEB)

    Drach, Vincent; Jansen, Karl [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Carbonell, Jaume; Papinutto, Mauro [UJF, CNRS/IN2P3, INPG (France). Lab. de Physique Subatomique et de Cosmologie; Alexandrou, Constantia [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics

    2010-12-15

    We present first results on the octet and decuplet strange baryon spectrum with N{sub f}=2+1+1 twisted mass quarks. We use an Osterwalder Seiler valence strange quark with a mass tuned to the kaon and compare the results with those obtained in the unitary setup. This comparison allows to perform a first study of the lattice artefacts introduced by the mixed action approach. We investigate the effect of the strange and charm quarks in the sea by using two lattice spacings and comparing with preceding N{sub f}=2 twisted mass fermion calculations. (orig.)

  10. Nucleon matrix elements with $N_f=2+1+1$ maximally twisted fermions

    CERN Document Server

    Dinter, Simon; Constantinou, Martha; Drach, Vincent; Jansen, Karl; Renner, Dru

    2010-01-01

    We present the first lattice calculation of nucleon matrix elements using four dynamical flavors. We use the $N_f=2+1+1$ maximally twisted mass formulation. The renormalization is performed non-perturbatively in the RI$^\\prime$-MOM scheme and results are given for the vector and axial vector operators with up to one-derivative. Our calculation of the average momentum of the unpolarized non-singlet parton distribution is presented and compared to our previous results obtained from the $N_f=2$ case.

  11. Monitoring of therapy in head and neck patients during the radiotherapy by measurement of Cyfra 21-1; Le Cyfra 21-1 est-il un bon marqueur dans le suivi de patients atteints de cancer ORL?

    Energy Technology Data Exchange (ETDEWEB)

    Pradier, O.; Hille, A.; Schmiberger, H.; Hess, C.F. [Gottingen Universitat, Dept. of Radiotherapy, (Germany)

    2002-02-01

    Purpose. - Cyfra 21-1, measuring serum fragments of cyto-keratin 19, has been found to be related to tumour stage and tumour size in patients with cervical cancer. It could be a promising marker in squamous lung cancer. We evaluated this new marker with carcinoembryonic antigen, (CEA) and squamous cell carcinoma antigen (SCC-Ag) in the monitoring of 27 patients with head and neck cancer. Patients and methods. -The retrospective study group consisted of 27 patients, 17 not suited for surgery and 10 after laser resection. Patients were clinically staged according to the TNM-classification. The mean age of the patients was 53 years (range 37-70 years). Serum levels of each marker were studied in relation to tumour stage and clinical status of the patients during radiotherapy and 6 weeks after the end of the treatment. The clinical performance of the various assays to separate those patients with complete remission from those patients with the presence of tumour was assessed. Results. - Pre-treatment serum Cyfra 21-1, CEA, and SCC-Ag levels were not related to stage of disease and were not found to be predictive of tumour response. The clinical performance of post-treatment serum SCC-Ag levels in predicting the presence of tumour was not better than the Cyfra 21-1 assays. Conclusion. - We could not conclude from this study that Cyfra 21-1 marker is an additional parameter in identifying patients at risk of residual tumour after treatment, recurrent or progressive disease. An elevation of Cyfra 21-1 marker was not detectable in 70% of the cases with macroscopic tumour. Therefore, Cyfra 21-1 is not a reliable parameter for the monitoring of patients with head and.neck cancer during radiotherapy. (authors)

  12. Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of α-particle-emitting 211At-labeled trastuzumab

    International Nuclear Information System (INIS)

    Introduction: Carcinomatous meningitis (CM) is a devastating disease characterized by the dissemination of malignant tumor cells into the subarachnoid space along the brain and spine. Systemic treatment with monoclonal antibody (mAb) trastuzumab can be effective against HER2-positive systemic breast carcinoma but, like other therapies, is ineffective against CM. The goal of this study was to evaluate the therapeutic effect of α-particle emitting 211At-labeled trastuzumab following intrathecal administration in a rat model of breast carcinoma CM. Methods: Athymic rats were injected intrathecally with MCF-7/HER2-18 breast carcinoma cells through a surgically implanted indwelling intrathecal catheter. In Experiment 1, animals received 33 or 66 μCi 211At-labeled trastuzumab, cold trastuzumab or saline. In Experiment 2, animals were inoculated with a lower tumor burden and received 46 or 92 μCi 211At-labeled trastuzumab or saline. In Experiment 3, animals received 28 μCi 211At-labeled trastuzumab, 30 μCi 211At-labeled TPS3.2 control mAb or saline. Histopathological analysis of the neuroaxis was performed at the end of the study. Results: In Experiment 1, median survival increased from 21 days for the saline and cold trastuzumab groups to 45 and 48 days for 33 and 66 μCi 211At-labeled trastuzumab, respectively. In Experiment 2, median survival increased from 23 days for saline controls to 68 and 92 days for 46 and 92 μCi 211At-labeled trastuzumab, respectively. In Experiment 3, median survival increased from 20 days to 29 and 36 days for animals treated with 211At-labeled TPS3.2 and 211At-labeled trastuzumab, respectively. Long-term survivors were observed exclusively in the 211At-trastuzumab-treated groups. Conclusion: Intrathecal 211At-labeled trastuzumab shows promise as a treatment for patients with HER2-positive breast CM.

  13. MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.

    Science.gov (United States)

    Yu, Haizhou; Yang, Weixi

    2016-08-01

    MiR-211 has strong inhibitive effects on melanoma cell growth, invasion and metastasis. However, how it is downregulated and whether other genes are involved its downstream regulation in melanoma are not clear. In this study, we firstly verified the expression of miR-211 in melanoma cell lines and observed that its downregulation is associated with increased DNMT1 expression. By performing qRT-PCR and MSP analysis, we confirmed that DNMT1 is negatively correlated with miR-211 expression and can modulate DNA methylation in the promoter region of miR-211. By performing bioinformatics analysis, we found that RAB22A is a possible target of miR-211, which has two broadly conversed binding sites with miR-211 in the 3'UTR. Following dual luciferase assay, qRT-PCR and western blot analysis confirmed the direct binding between miR-211 and RAB22A and the suppressive effect of miR-211 on RAB22A expression. Knockdown of RAB22A increased epithelial properties and impaired mesenchymal properties of the melanoma cells, suggesting that miR-211 modulates epithelial mesenchymal transition (EMT) of melanoma cells via downregulating RAB22A. In summary, the present study firstly demonstrated that DNMT1 mediated promoter methylation is a mechanism of miRNA suppression in melanoma and revealed a new tumor suppressor role of the miR-211 by targeting RAB22A in melanoma. The DNMT1/miR-211/RAB22A axis provides a novel insight into the pathogenesis of melanoma, particularly in the EMT process. PMID:27237979

  14. Radiopharmaceutical for differential diagnosis of tuberculoma: synthesis of 2-[11C]cyano-isonicotinic acid hydrazide

    International Nuclear Information System (INIS)

    The radiochemical synthesis of 2-[11C]cyano-isonicotinic acid hydrazide was accomplished. Carbon-11 labelled cyano-group was introduced at the 2-position of the pyridine ring of 1-methoxy-4-methoxycarbonyl pyridinium methyl sulfate via a Riessert-Kaufmann type reaction. The reaction was performed on a solid support (silica gel) to yield no-carrier-added methyl 2-[11C]cyano-isonicotinate in (32.4 ± 12%) (EOB) yield. This method is unique for the incorporation of [11C]HCN to base sensitive substrates. The carbon-11 labelled methyl ester was treated with hydrazine hydrate to obtain 2-[11C]cyano-isonicotinic acid hydrazide. The final radiochemical yield was 10% (EOB) and the synthesis time was approximately 35 min. (author)

  15. Proactive screening for health needs in United Way’s 2-1-1 information and referral service

    Science.gov (United States)

    Eddens, Katherine S.; Kreuter, Matthew W.

    2011-01-01

    Cancer disproportionately affects the underserved. United Way 2-1-1 is an information and referral system that links underserved populations to community services. This study explores the feasibility of integrating proactive screening and referral to health services into 2-1-1. A cancer risk assessment was administered to callers (n=297), measuring their need for six cancer control services. A subset of respondents was randomized to receive generic or tailored referrals to needed services. Nearly all participants (85%) needed at least one of the services. Those who received tailored referrals were more likely to make appointments. Future research will explore approaches to address and eliminate health disparities through 2-1-1. PMID:21566702

  16. OH+ and H2O+ absorption toward PKS1830-211

    CERN Document Server

    Muller, S; Black, J H; Beelen, A; Combes, F; Curran, S; Gerin, M; Guelin, M; Henkel, C; Martin, S; Aalto, S; Falgarone, E; Menten, K M; Schilke, P; Wiklind, T; Zwaan, M A

    2016-01-01

    We report the detection of OH+ and H2O+ in the z=0.89 absorber toward the lensed quasar PKS1830-211. The abundance ratio of OH+ and H2O+ is used to quantify the molecular hydrogen fraction (fH2) and the cosmic-ray ionization rate of atomic hydrogen (zH) along two lines of sight, located at ~2 kpc and ~4 kpc to either side of the absorber's center. The molecular fraction decreases outwards, from ~0.04 to ~0.02, comparable to values measured in the Milky Way at similar galactocentric radii. For zH, we find values of ~2x10^-14 s^-1 and ~3x10^-15 s^-1, respectively, which are slightly higher than in the Milky Way at comparable galactocentric radii, possibly due to a higher average star formation activity in the z=0.89 absorber. The ALMA observations of OH+, H2O+, and other hydrides toward PKS1830-211 reveal the multi-phase composition of the absorbing gas. Taking the column density ratios along the southwest and northeast lines of sight as a proxy of molecular fraction, we classify the species ArH+, OH+, H2Cl+, H...

  17. The Dynamics of the Envelope Surrounding the Protostar HH 211-mm

    CERN Document Server

    Tanner, Joel D

    2010-01-01

    We present a study of the structure and dynamics of the dense gas surrounding the HH 211-mm source, using VLA observations of the ammonia (1,1) and (2,2) inversion transitions. We find the envelope around this Class 0 source has an elongated geometry, extending about 104 AU in the direction perpendicular to the well-known HH 211 jet, and exhibits a velocity distribution consistent with rotation along the major axis. Our VLA observations indicate that the envelope is mostly in virial equilibrium. However, comparing our data with results from previous studies it appears that the gas within approximately 0.005 pc of the central protostar is undergoing dynamical collapse. The size of this collapsing radius may constrain the amount of mass that can eventually infall into the forming star. We also find that the envelope is mostly internally heated, most probably by radiation from the central protostar. In addition, we detect evidence of outflow-envelope interaction in the ammonia data. These include a velocity grad...

  18. Fabrication of YBCO coated conductor by TFA-MOD using the '211 process'

    International Nuclear Information System (INIS)

    YBCO film was fabricated by the TFA-MOD method based on the '211 process' in which precursors of Y2Ba1Cu1O x (Y211) and Ba3Cu5O8 powders, instead of Y-, Ba-, and Cu-based acetates, were dissolved in trifluoroacetic acid (TFA) in order to explore its possible application in coated conductors. We evaluated the effects of the humidity and firing temperature on the phase formation, texture formability, and critical temperature (T c) and current (I c) of the YBCO film. We successively synthesized pure YBCO films of which those fired in 12.1-20.0% humidified Ar gas showed the highest critical properties, viz. a T c-zero of 88.6 K and I c of 30 A/cm width. These improvements in the critical properties were attributed to the formation of pure YBCO phase, to the improved density and the large grain size. In addition, we observed that the I c varied significantly with the firing temperature. The variation of the I c with the firing temperature was correlated with the microstructural evolution

  19. Monitoring of therapy in head and neck patients during the radiotherapy by measurement of Cyfra 21-1

    International Nuclear Information System (INIS)

    Purpose. - Cyfra 21-1, measuring serum fragments of cyto-keratin 19, has been found to be related to tumour stage and tumour size in patients with cervical cancer. It could be a promising marker in squamous lung cancer. We evaluated this new marker with carcinoembryonic antigen, (CEA) and squamous cell carcinoma antigen (SCC-Ag) in the monitoring of 27 patients with head and neck cancer. Patients and methods. -The retrospective study group consisted of 27 patients, 17 not suited for surgery and 10 after laser resection. Patients were clinically staged according to the TNM-classification. The mean age of the patients was 53 years (range 37-70 years). Serum levels of each marker were studied in relation to tumour stage and clinical status of the patients during radiotherapy and 6 weeks after the end of the treatment. The clinical performance of the various assays to separate those patients with complete remission from those patients with the presence of tumour was assessed. Results. - Pre-treatment serum Cyfra 21-1, CEA, and SCC-Ag levels were not related to stage of disease and were not found to be predictive of tumour response. The clinical performance of post-treatment serum SCC-Ag levels in predicting the presence of tumour was not better than the Cyfra 21-1 assays. Conclusion. - We could not conclude from this study that Cyfra 21-1 marker is an additional parameter in identifying patients at risk of residual tumour after treatment, recurrent or progressive disease. An elevation of Cyfra 21-1 marker was not detectable in 70% of the cases with macroscopic tumour. Therefore, Cyfra 21-1 is not a reliable parameter for the monitoring of patients with head and.neck cancer during radiotherapy. (authors)

  20. Serum tumor marker CYFRA 21-1 in the diagnostics of squamous cell lung cancer - comparison with CEA

    International Nuclear Information System (INIS)

    The aim of the study was to test the diagnostic value tumor marker CYFRA 21-1 for squamous cell lung cancer (SQCLC) in comparison with carcinoembryonic antigen (CEA). Ninety-one patients were induced in this study: 56 with SQCLC - Group I, 25 with other types of lung cancer - Group II, 10 with benign respiratory tract diseases - Group III. Median CYFRA 21-1 serum concentration (ng/ml) was: in Group I: 4.52 (0.94 - >16), in Group II: 3.58 (1.72 - >16), in Group III: 2.05 (0.99 - 3.41). Median CEA serum concentration (ng/ml) was: in Group I: 4.49 (076- >20), in Group II: 3.32 (1.17 - >20), in Group III: 3.09 (1.84 - 6.37). There was a highly significant difference between the levels of CYFRA 21-1 in group I and Group III (p < 0.001), but there was no statistically significant difference between the levels of CEA in Group I and III. Sensitivity of CYFRA 21-1 by the cut-off 3.33 ng/ml in the diagnostics of SQCLC was 0.68, specificity 0.090, positive predictive value 0.91, negative predictive value 0.65. Sensitivity of CEA by cut-off 4.61 ng/ml was 0.5 by the same specificity 0.90. CYFRA 21-1 has high sensitivity, specificity and positive predictive value in the diagnostics of SQCLC. Sensitivity of CYFRA 21-1 is significantly higher than sensitivity of CEA in this settings. (author)

  1. Tumor marker CYFRA 21-1 in assessment of radiation treatment efficacy at local non-small-cell lung cancer

    International Nuclear Information System (INIS)

    The results of radiation therapy (RT) at various fractionation modes with Etopiside and Cysplatin modification in patients with non-small-cell lung cancer (NSCLC) are analyzed. The objective effect of accelerated RT was accompanied by statistically significant reduction of blood serum CYFRA 21-1 level (an index of proteolytic tumor degradation). It was established that the dynamics of blood serum CYFRA 21-1 expression coincided with the clinical findings and could be used for prognosis and monitoring of chemoradiation therapy efficacy in patients with NSCLC.

  2. CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach

    OpenAIRE

    Gruber, Christine; Hatz, Rudolf; Reinmiedl, Judith; Nagel, Dorothea; Stieber, Petra

    2008-01-01

    We retrospectively studied the single and combined diagnostic value of carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), neuron specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP), which were routinely analysed in patients with lung tumours of unknown origin at the time of admission to hospital. Inclusion criteria were the determination of CEA (AxSYM/Abbott), CYFRA 21-1 (ElecSys/Roche) and NSE (Kryptor/Brahms). We examined 1747 patients, where 1325 suffered f...

  3. Evaluation of a new tumour marker in patients with non-small-cell lung cancer: Cyfra 21.1.

    OpenAIRE

    van der Gaast, A; Schoenmakers, C. H.; Kok, T.C.; Blijenberg, B. G.; Cornillie, F.; Splinter, T A

    1994-01-01

    The Cyfra 21.1 assay is a newly developed test which measures in serum a fragment of cytokeratin 19. We evaluated this marker in 212 patients with non-small-cell lung cancer (NSCLC), predominantly stage 3a-b and 4, and compared it with three other markers: carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC) and tissue polypeptide antigen (TPA). Sensitivities for Cyfra 21.1, TPA, CEA and SCC (using cut-off levels corresponding to a 95% specificity for benign lung diseases) we...

  4. Hydrodeoxygenation of Phenol to Benzene and Cyclohexane on Rh(111) and Rh(211) Surfaces: Insights from Density Functional Theory

    DEFF Research Database (Denmark)

    Garcia-Pintos, Delfina; Voss, Johannes; Jensen, Anker Degn;

    2016-01-01

    Herein we describe the C-O cleavage of phenol and cyclohexanol over Rh (111) and Rh (211) surfaces using density functional theory calculations. Our analysis is complemented by a microkinetic model of the reactions, which indicates that the C-O bond cleavage of cyclohexanol is easier than...... that of phenol and that Rh (211) is more active than Rh (111) for both reactions. This indicates that phenol will react mainly following a pathway of initial hydrogenation to cyclohexanol followed by hydrodeoxygenation to cyclohexane. We show that there is a general relationship between the transition state...

  5. Synthesis of trapezohedral indium oxide nanoparticles with high-index {211} facets and high gas sensing activity.

    Science.gov (United States)

    Han, Xiguang; Han, Xiao; Sun, Linqiang; Gao, Shengguang; Li, Liang; Kuang, Qin; Xie, Zhaoxiong; Wang, Chao

    2015-06-14

    Nanocrystals with high-index facets usually exhibit higher catalytic activities than those with only low-index facets. Trapezohedron-shaped (TS) In2O3 particles with exposed high-index {211} facets were successfully synthesized in an oleic acid (OA) and trioctylamine (TOA) system. It has been demonstrated that the gas sensing activity of TS In2O3 particles with exposed high-index {211} facets is higher than that of octahedron-shaped In2O3 particles with exposed low-index {111} facets.

  6. Low lying yrast states in 210 Rn and 211Rn and the competition between neutron-hole and proton excitations

    International Nuclear Information System (INIS)

    The γ-decay and nuclear structure of low lying yrast and near yrast levels in 210Rn and 211Rn have been investigated. The cascade from the yrast 6+ state in 210Rn branches to two close lying 4+ states, deduced to be complete mixtures of the 4+ states arising from the proton configuration, and from the neutron-hole intruder configuration. The influence of this proton, neutron-hole interaction on the yrast cascades in 211Rn and 206Rn, 208Rn is discussed

  7. 33 CFR 211.6 - Rights which may be granted by the Secretary of the Army in river and harbor and flood control...

    Science.gov (United States)

    2010-07-01

    ... the Secretary of the Army in river and harbor and flood control property. 211.6 Section 211.6... and flood control property. (a) Leases. (1) The Secretary of the Army is authorized, whenever he shall deem it to be advantageous to the Government, to lease such real property under the control of...

  8. Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

    Science.gov (United States)

    He, Xiaolie; Zhu, Yanjing; Wang, Mei; Jing, Guoxin; Zhu, Rongrong; Wang, Shilong

    2016-01-01

    Major depression is a complex neuropsychiatric disorder with few treatment approaches. The use of nontargeted antidepressants induced many side effects with their low efficacy. A more precise targeting strategy is to develop nanotechnology-based drug delivery systems; hence, we employed solid lipid nanoparticles (SLNs) to encapsulate HU-211 and curcumin (Cur). The antidepressant effects of the dual-drug nanoparticles (Cur/SLNs-HU-211) for major depression treatment were investigated in corticosterone-induced cellular and animal models of major depression. Cur/SLNs-HU-211 can effectively protect PC12 cells from corticosterone-induced apoptosis and can release more dopamine, which may be associated with the higher uptake of Cur/SLNs-HU-211 shown by cellular uptake behavior analysis. Additionally, Cur/SLNs-HU-211 significantly reduced the immobility time in forced swim test, enhanced fall latency in rotarod test, and improved the level of dopamine in mice blood. Cur/SLNs-HU-211 can deliver more Cur to the brain and thus produce a significant increase in neurotransmitters level in brain tissue, especially in the hippocampus and striatum. The results of Western blot and immunofluorescence revealed that Cur/SLNs-HU-211 can significantly enhance the expression of CB1, p-MEK1, and p-ERK1/2. Our study suggests that Cur/SLNs-HU-211 may have great potential for major depression treatment. PMID:27757031

  9. 41 CFR 301-71.211 - Is there a minimum amount the late payment fee must exceed before we will pay it?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Is there a minimum amount the late payment fee must exceed before we will pay it? 301-71.211 Section 301-71.211 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY...

  10. Epidemiology analysis of 211 hospitallized patients with acute renal failure%211例急性肾功能衰竭的流行病学分析

    Institute of Scientific and Technical Information of China (English)

    王悦; 崔专; 范敏华

    2005-01-01

    目的探讨急性肾功能衰竭(acute renal failure,ARF)流行病学和预后变化及其相关因素.方法收集北京大学第三医院近10年出院病例中含有ARF诊断的患者的临床资料,重新确认诊断后,分析流行病学、预后及其相关因素变化.结果共搜集并确认ARF 211例,占同期出院患者的1.2‰,近5年呈增高趋势.医院获得性ARF在2000年后显著增高(P<0.05),尤其ICU患者的ARF发病率增加1.07倍.患者病亡率高达37.91%,并有继续增高的趋势,其中医院获得性ARF显著高于社区获得性ARF(P<0.01).结论近10年来,住院患者中ARF比率呈增加趋势,而预后无明显改善,医院获得性ARF发生率增加是主要原因.

  11. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  12. Fine-needle aspirate CYFRA 21-1, an innovative new marker for diagnosis of axillary lymph node metastasis in breast cancer patients.

    Science.gov (United States)

    Choi, Ji Soo; Han, Kyung Hwa; Kim, Eun-Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Kim, Min Jung

    2015-05-01

    To compare the value of cytokeratin fragment 21-1 (CYFRA 21-1) concentration in the fine-needle biopsy aspirates (fine needle aspirate [FNA] CYFRA 21-1) with cytopathology of fine-needle aspiration biopsy (FNA cytology) and to assess whether CYFRA 21-1 concentrations from ultrasound-guided fine-needle aspiration biopsy (US-FNAB) specimens (FNA CYFRA 21-1) is not inferior to FNA cytology in the diagnosis of axillary lymph node (ALN) metastasis of breast cancer patients.This study received institutional review board approval, and written informed consent was obtained from all patients. US-FNAB was performed in 373 ALNs from 358 patients with invasive breast cancer. Concentrations of CYFRA 21-1 were measured from washouts of the syringe used during US-FNAB (FNA CYFRA 21-1), and ALN metastasis was determined using a cutoff value of 1.93 ng/mL. FNA cytology, intraoperative sentinel lymph node biopsy, and surgical pathology results were reviewed and analyzed. The noninferiority margin for the difference in accuracies between FNA cytology and FNA CYFRA 21-1 was set as 5%.Among 373 ALNs, 136 (36.5%) were benign, and 237 (63.5%) were metastatic. The mean FNA CYFRA 21-1 was significantly higher in metastatic ALNs compared to that in benign ALNs (P = 0.001). For the diagnosis of ALN metastasis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FNA CYFRA 21-1 (cutoff value 1.93 ng/mL) were not significantly different from those of FNA cytology (P > 0.05). FNA CYFRA 21-1 reached statistical noninferiority to FNA cytology in terms of diagnostic accuracy for ALN metastasis. Of the 20 ALNs (8 metastasis, 12 benign) that showed insufficient results on FNA cytology, FNA CYFRA 21-1 accurately diagnosed 15 ALNs (4 metastasis, 11 benign).The diagnostic performance of FNA CYFRA 21-1 is comparable with that of FNA cytology for breast cancer ALN metastasis. Our results indicate that FNA CYFRA 21-1, using an US-FNAB specimen

  13. 211”高校图书馆信息系统管理的关键问题%Key Issues of Information System Management in"211"Academic Libraries

    Institute of Scientific and Technical Information of China (English)

    肖鹏; 陈定权

    2014-01-01

    文章基于图书馆领域的关键问题研究模式,以“211”高校图书馆为调研样本,统计分析出高校图书馆信息系统管理的以“纸本资源与电子资源的深度整合”为首的十大关键问题,对“211”高校图书馆信息主管的工作重点进行了探讨,并对未来3到5年的高校信息化发展战略提出了策略性建议。%Based on the key issues research pat ern in library science, an empirical study is conducted on the information system management of Project 211 Academic Library. The study founds the result of top ten key issues headed by"Deep integration of paper resources and electronic resources,"discusses four kinds of job duties of information manager, and gives some suggestions to strategic planning of Project 211 Academic Library in 3 to 5 years.

  14. Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

    Energy Technology Data Exchange (ETDEWEB)

    Orozco, Johnnie J.; Back, Tom; Kenoyer, Aimee L.; Balkin, Ethan R.; Hamlin, Donald K.; Wilbur, D. Scott; Fisher, Darrell R.; Frayo, Shani; Hylarides, Mark; Green, Damian J.; Gopal, Ajay K.; Press, Oliver W.; Pagel, John M.

    2013-05-15

    Anti-CD45 Radioimmunotherapy using an Alpha-Emitting Radionuclide 211At Combined with Bone Marrow Transplantation Prolongs Survival in a Disseminated Murine Leukemia Model ABSTRACT Despite aggressive chemotherapy combined with hematopoietic cell transplant (HCT), many patients with acute myeloid leukemia (AML) relapse. Radioimmunotherapy (RIT) using antibodies (Ab) labeled primarily with beta-emitting radionuclides has been explored to reduce relapse.

  15. Closure report for Corrective Action Unit 211, Area 15 EPA Farm waste sites, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    This Closure Report summarizes the corrective actions which were completed at the Corrective Action Sites within Corrective Action Unit 211 Area 15 Farm Waste Sties at the Nevada Test Site. Current site descriptions, observations and identification of wastes removed are included on FFACO Corrective Action Site housekeeping closure verification forms

  16. Thick target yield measurement of {sup 211}At through the nuclear reaction {sup 209}Bi({alpha}, 2n)

    Energy Technology Data Exchange (ETDEWEB)

    Alfarano, A [Institute for Health and Consumer Protection, IHCP, Joint Research Centre, via E. Fermi 1, 21020 Ispra, Varese (Italy); Abbas, K [Institute for Health and Consumer Protection, IHCP, Joint Research Centre, via E. Fermi 1, 21020 Ispra, Varese (Italy); Holzwarth, U [Institute for Health and Consumer Protection, IHCP, Joint Research Centre, via E. Fermi 1, 21020 Ispra, Varese (Italy); Bonardi, M [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, 20090 Segrate, Milan (Italy); Groppi, F [Universita degli Studi di Milano and INFN-Milano, LASA, Radiochemistry Laboratory, via F.lli Cervi 201, 20090 Segrate, Milan (Italy); Alfassi, Z [Department of Nuclear Engineering, Ben Gurion University, 84105 Beer Sheva (Israel); Menapace, E [ENEA, Applied Physics Division, Bologna (Italy); Gibson, P N [Institute for Health and Consumer Protection, IHCP, Joint Research Centre, via E. Fermi 1, 21020 Ispra, Varese (Italy)

    2006-05-15

    Radionuclide Therapy (RNT) and Radioimmunotherapy (RIT) are potentially of great interest for cancer therapy. In many therapeutic applications alpha emitters should be much more effective than already-approved beta emitters due to the short range and high linear energy transfer of alpha particles. {sup 213}Bi is an important alpha emitter already used in clinical trials but the half-life of this radioisotope is short (46 minutes) and so its use is limited for certain therapies. {sup 211}At is potentially very interesting for medical purposes because of its longer half-life of 7.2 hours, and suitable decay scheme. We have studied the cyclotron-based production of {sup 211}At via the reaction {sup 209}Bi({alpha}, 2n), this production route probably being the most promising in the long term. The energy dependence of thick target yields and the reaction cross sections for the production of {sup 211}At and {sup 210}At were determined and found to be in good agreement with literature. The best energy to produce {sup 211}At is 28-29 MeV. The possible production of the undesired, highly radiotoxic, and long-lived alpha-emitting {sup 210}Po (138.38 days), which is produced from decay of {sup 210}At, is also discussed.

  17. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  18. The Arabidopsis AP2/ERF Transcription Factor RAP2.11 Modulates Plant Response to Low-Potassium Conditions

    Institute of Scientific and Technical Information of China (English)

    Min Jung Kim; Daniel Ruzicka; Ryoung Shin; Daniel P.Schachtman

    2012-01-01

    Plants respond to low-nutrient conditions through metabolic and morphology changes that increase their ability to survive and grow.The transcription factor RAP2.11 was identified as a component in the response to low potassium through regulation of the high-affinity K+ uptake transporter AtHAK5 and other components of the lowpotassium signal transduction pathway.RAP2.11 was identified through the activation tagging of Arabidopsis lines that contained a luciferase marker driven by the AtHAK5 promoter that is normally only induced by low potassium.This factor bound to a GCC-box of the AtHAK5 promoter in vitro and in vivo.Transcript profiling revealed that a large number of genes were up-regulated in roots by RAP2.11 overexpression.Many regulated genes were identified to be in functional categories that are important in low-K+ signaling.These categories included ethylene signaling,reactive oxygen species production,and calcium signaling.Promoter regions of the up-regulated genes were enriched in the GCCGGC motif also contained in the AtHAK5 promoter.These results suggest that RAP2.11 regulates AtHAK5 expression under low-K+ conditions and also contributes to a coordinated response to low-potassium conditions through the regulation of other genes in the low-K+ signaling cascade.

  19. 76 FR 40217 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-524 Series Turbofan Engines

    Science.gov (United States)

    2011-07-08

    ... Register published on April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or...; AD 2011-13-01] RIN 2120-AA64 Airworthiness Directives; Rolls-Royce plc (RR) RB211-524 Series...

  20. 77 FR 10355 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-Trent 800 Series Turbofan Engines

    Science.gov (United States)

    2012-02-22

    ... (68 FR 49344, August 18, 2003) and adding the following new AD: 2012-04-01 Rolls-Royce plc: Amendment... (68 FR 49344, August 18, 2003). (c) Applicability This AD applies to Rolls-Royce plc (RR) RB211-Trent...) 2003-16- 18, amendment 39-13271 (68 FR 49344, August 18, 2003). That AD applies to the...

  1. Renormalization constants for $N_{\\rm f}=2+1+1$ twisted mass QCD

    CERN Document Server

    Blossier, Benoit; Guichon, Pierre; Morénas, Vincent; Pène, Olivier; Rodríguez-Quintero, Jose; Zafeiropoulos, Savvas

    2014-01-01

    We summarize recent non-perturbative results obtained for the renormalization constants computed in the RI'-MOM scheme for $N_{\\rm f}=2+1+1$ twisted mass QCD. Our implementation employs the Iwasaki gauge action and four dynamical degenerate twisted mass fermions. Renormalization constants for scalar, pseudo-scalar, vector and axial operators, as well as the quark propagator renormalization, are computed at three different values of the lattice spacing, two different volumes and several values of the twisted mass. Our method allows for a precise cross-check of the running, because of the particular proper treatment of the hypercubic artifacts. Preliminary results for twist-2 operators are also presented.

  2. First results of ETMC simulations with Nf=2+1+1 maximally twisted mass fermions

    CERN Document Server

    Baron, R; Boucaud, P; Deuzeman, A; Drach, V; Farchioni, F; Gimenez, V; Herdoiza, G; Jansen, K; Michael, C; Montvay, I; Palao, D; Pallante, E; Pène, O; Reker, S; Urbach, C; Wagner, M; Wenger, U

    2009-01-01

    We present first results from runs performed with Nf=2+1+1 flavours of dynamical twisted mass fermions at maximal twist: a degenerate light doublet and a mass split heavy doublet. An overview of the input parameters and tuning status of our ensembles is given, together with a comparison with results obtained with Nf=2 flavours. The problem of extracting the mass of the K- and D-mesons is discussed, and the tuning of the strange and charm quark masses examined. Finally we compare two methods of extracting the lattice spacings to check the consistency of our data and we present some first results of ChiPT fits in the light meson sector.

  3. Properties of pseudoscalar flavour-singlet mesons from 2+1+1 twisted mass lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Cichy, Krzysztof [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Poznan Univ. (Poland). Faculty of Physics; Drach, Vincent; Garcia Ramos, Elena; Jansen, Karl [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Michael, Chris [Liverpool Univ. (United Kingdom). Dept. of Mathematical Sciences; Ottnad, Konstantin; Urbach, Carsten; Zimmermann, Falk [Bonn Univ. (Germany). Inst. fuer Strahlen- und Kernphysik

    2012-11-15

    We study properties of pseudoscalar flavour-singlet mesons from Wilson twisted mass lattice QCD with N{sub f}=2+1+1 dynamical quark flavors. Results for masses are presented at three values of the lattice spacing and light quark masses corresponding to values of the pion mass from 230 MeV to 500 MeV. We briefly discuss scaling effects and the light and strange quark mass dependence of M{sub {eta}}. In addition we present an exploratory study using Osterwalder-Seiler type strange and charm valence quarks. This approach avoids some of the complications of the twisted mass heavy doublet. We present first results for matching valence and unitary actions and a comparison of statistical uncertainties.

  4. Plan for the Initiation of HA-211 Furnace Operations at the Plutonium Finishing Plan (PFP)

    International Nuclear Information System (INIS)

    This plan provides a phased approach authorizing the use of three additional muffle furnaces for thermal stabilization. Achievement of Thermal Stabilization mission elements require the installation and startup of three additional muffle furnaces for the thermal stabilization of plutonium and plutonium bearing materials at the Plutonium Finishing Plant (PFP). The release to operate these additional furnaces will require an Activity Based Startup Review. The conduct of the Activity Based Startup Review (ABSR) was approved by Fluor Daniel Hanford on October 15, 1999. This plan has been developed with the objective of identifying those activities needed to guide the controlled startup of five furnaces from authorization to unrestricted operations by adding the HA-211 furnaces in an orderly and safe manner after the approval to Startup has been given

  5. CYFRA 21-1与头颈部鳞癌(综述)

    Institute of Scientific and Technical Information of China (English)

    闵钟云; 李顺玉; 郭星

    2002-01-01

    CYFRA 21-1是细胞角蛋白19可溶性片段,有特异性抗体KS19.1和BM19.21,在头颈部鳞癌检测中特异性高,其水平随临床分期的进展而增高,与淋巴结及远处转移、局部复发均有关;其敏感性优于SCCAg、CEA,结合其它标记物检测,敏感性提高,对头颈部鳞癌的早期诊断,疗效评估,预后监测等均有意义.

  6. Baryon spectrum using Nf=2+1+1 ensembles of twisted mass fermions

    CERN Document Server

    Alexandrou, C; Hadjiyiannakou, K; Jansen, K; Kallidonis, C; Koutsou, G

    2014-01-01

    We present results on the masses of the low-lying baryons using ten ensembles of gauge configurations with $N_f =2+1+1$ dynamical twisted mass fermions, at three values of the lattice spacing, spanning a pion mass range from about 210 MeV to about 430 MeV. The strange and charm quark masses are tuned to approximately their physical values. We examine isospin symmetry breaking effects on the baryon mass and the dependence on the lattice spacing. After taking the continuum limit we use chiral perturbation theory to extrapolate to the physical vlaue of the pion mass for all forty baryons. We provide predictions for the masses of doubly and triply charmed baryons that have not yet been measured experimentally.

  7. Project Execution Plan for Project W-211 Initial Tank Retrieval Systems (ITRS)

    International Nuclear Information System (INIS)

    This Project Execution Plan documents the methodology for managing Project W-211. Project W-211, Initial Tank Retrieval Systems (ITRS), is a fiscal year 1994 Major Systems Acquisition that will provide systems for retrieval of radioactive wastes from selected double-shell tanks (DST). The contents of these tanks are a combination of supernatant liquids and settled solids. To retrieve waste from the tanks, it is first necessary to mix the liquid and solids prior to transferring the slurry to alternative storage or treatment facilities. The ITRS will provide systems to mobilize the settled solids and transfer the wastes out of the tanks. In so doing, ITRS provides feed for the future waste treatment plant, allows for consolidation of tank solids to manage space within existing DST storage capacity, and supports continued safe storage of tank waste. The ITRS scope has been revised to include waste retrieval systems for tanks AP-102, AP-104, AN-102, AN-103, AN-104, AN-105, AY-102, AZ-102, and SY-102. This current tank selection and sequence provides retrieval systems supporting the River Protection Project (RF'P) Waste Treatment Facility and sustains the ability to provide final remediation of several watch list DSTs via treatment. The ITRS is configured to support changing program needs, as constrained by available budget, by maintaining the flexibility for exchanging tanks requiring mixer pump-based retrieval systems and shifting the retrieval sequence. Preliminary design was configured such that an adequate basis exists for initiating Title II design of a mixer pump-based retrieval system for any DST. This Project Execution Plan (PEP), derived from the predecessor Project Management Plan, documents the methodology for managing the ITRS, formalizes organizational responsibilities and interfaces, and identifies project requirements such as change control, design verification, systems engineering, and human factors engineering

  8. Clinical value of CYFRA 21-1, HER-2/ neu and NSE in differential diagnosis of pleural effusion%CYFRA 21-1,HER-2/neu及NSE在胸腔积液鉴别诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    林桦; 丘世飏; 孙圣华

    2010-01-01

    目的:探讨肿瘤标志物细胞角蛋白片段抗原21-1(CYFRA 21-1)、人体表皮生长因子受体-2(HER-2/neu)和神经元烯醇化酶(NSE)对良、恶性胸水鉴别诊断的临床应用价值.方法:分别用放射免疫法及ELISA法,定量检测62例恶性及48例良性胸腔积液患者血清和胸腔积液中CYFRA 21-1、HER-2/neu和NSE的含量.通过受试者工作特征(ROC)曲线分析各指标的临床性能,并确定其截断点(cut off value).结果:恶性胸水患者血清及胸水中CYFRA 21-1、HER-2/neu和NSE的含量均显著高于良性胸水患者(P<0.01).胸腔积液中CYFRA 21-1、HER-2/neu和NSE的含量明显高于血清(P<0.01或0.05).各指标的截断点分别为:血清NSE为11.40 μg/,L,胸腔积液NSE为16.47 μg/L;血清CYFRA 21-1为4.94 μg/L,胸腔积液CYFRA 21-1为7.70 μg/L;血清HER-2/neu为2.50 μg/L,胸腔积液HER-2/neu为3.50 μg/L.单独检测血清和胸腔积液CYFRA 21-1、HER-2/neu和NSE的ROC曲线下面积,分别为0.852、0.932,0.867、0.887和0.773、0.846,两两联合检测町使ROC曲线下面积增大,3项指标联合检测的ROC曲线下面积高达0.999.结论:检测胸水中的CYFRA 21-1、HER-2/neu和NSE,对良、恶性胸水的鉴别诊断具有一定的临床意义.运用ROC曲线分析可确定各项检测指标的截断点,科学地服务于临床.单个指标的检测有一定的局限性,只有综合利用多项检测指标对患者作出诊断,才能提高诊断的准确性.

  9. In vitro experimental {sup 211}At-anti-CD33 antibody therapy of leukaemia cells overcomes cellular resistance seen in vivo against gemtuzumab ozogamicin

    Energy Technology Data Exchange (ETDEWEB)

    Petrich, Thorsten; Korkmaz, Zekiye; Krull, Doris; Meyer, Geerd J.; Knapp, Wolfram H. [Hanover University School of Medicine, Department of Nuclear Medicine, Hanover (Germany); Froemke, Cornelia [Hanover University School of Medicine, Department of Biometry, Hanover (Germany)

    2010-05-15

    Monoclonal anti-CD33 antibodies conjugated with toxic calicheamicin derivative (gemtuzumab ozogamicin, GO) are a novel therapy option for acute myeloid leukaemia (AML). Key prognostic factors for patients with AML are high CD33 expression on the leukaemic cells and the ability to overcome mechanisms of resistance to cytotoxic chemotherapies, including drug efflux or other mechanisms decreasing apoptosis. Alpha particle-emitting radionuclides overwhelm such anti-apoptotic mechanisms by producing numerous DNA double-stranded breaks (DSBs) accompanied by decreased DNA repair. We labelled anti-CD33 antibodies with the alpha-emitter {sup 211}At and compared survival of leukaemic HL-60 and K-562 cells treated with the {sup 211}At-labelled antibodies, GO or unlabelled antibodies as controls. We also measured caspase-3/7 activity, DNA fragmentation and necrosis in HL-60 cells after treatment with the different antibodies or with free {sup 211}At. The mean labelling ratio of {sup 211}At-labelled antibodies was 1:1,090 {+-} 364 (range: 1:738-1:1,722) in comparison to 2-3:1 for GO. Tumour cell binding of {sup 211}At-anti-CD33 was high in the presence of abundant CD33 expression and could be specifically blocked by unlabelled anti-CD33. {sup 211}At-anti-CD33 decreased survival significantly more than did GO at comparable dilution (1:1,000). No significant differences in induction of apoptosis or necrosis or DNA DSB or in decreased survival were observed after {sup 211}At-anti-CD33 (1:1,090) versus GO (1:1) treatment. Our results suggest that {sup 211}At is a promising, highly cytotoxic radioimmunotherapy in CD33-positive leukaemia and kills tumour cells more efficiently than does calicheamicin-conjugated antibody. Labelling techniques leading to higher chemical yield and specific activities must be developed to increase {sup 211}At-anti-CD33 therapeutic effects. (orig.)

  10. Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

    Directory of Open Access Journals (Sweden)

    He XL

    2016-10-01

    Full Text Available Xiaolie He,* Yanjing Zhu,* Mei Wang, Guoxin Jing, Rongrong Zhu, Shilong Wang Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Major depression is a complex neuropsychiatric disorder with few treatment approaches. The use of nontargeted antidepressants induced many side effects with their low efficacy. A more precise targeting strategy is to develop nanotechnology-based drug delivery systems; hence, we employed solid lipid nanoparticles (SLNs to encapsulate HU-211 and curcumin (Cur. The antidepressant effects of the dual-drug nanoparticles (Cur/SLNs-HU-211 for major depression treatment were investigated in corticosterone-induced cellular and animal models of major depression. Cur/SLNs-HU-211 can effectively protect PC12 cells from corticosterone-induced apoptosis and can release more dopamine, which may be associated with the higher uptake of Cur/SLNs-HU-211 shown by cellular uptake behavior analysis. Additionally, Cur/SLNs-HU-211 significantly reduced the immobility time in forced swim test, enhanced fall latency in rotarod test, and improved the level of dopamine in mice blood. Cur/SLNs-HU-211 can deliver more Cur to the brain and thus produce a significant increase in neurotransmitters level in brain tissue, especially in the hippocampus and striatum. The results of Western blot and immunofluorescence revealed that Cur/SLNs-HU-211 can significantly enhance the expression of CB1, p-MEK1, and p-ERK1/2. Our study suggests that Cur/SLNs-HU-211 may have great potential for major depression treatment. Keywords: major depression, curcumin, HU-211, solid lipid nanoparticles, dopamine

  11. “985”“211”高校分类的法学思考%The Legal Thinking on College Classification of “985” and “211

    Institute of Scientific and Technical Information of China (English)

    吴玉姣

    2015-01-01

    法律视域下的“985”“211”高校分类,致使教育资源分配等方面存在不公平现象,而且通过实证分析发现选调生招考中“985”“211”高校门槛的设置造成了就业歧视后果的产生。这些不仅有违法理上的公平原则,且与《宪法》之平等原则、《劳动法》之禁止就业歧视条款、《就业促进法》有关就业公平的规定以及《公务员法》平等竞争、择优录取的办法等法律规范相冲突。质言之,“985”“211”高校分类背离了当时设立的初衷,理应被废除。%From the legal perspective , the university classification of “985” and “211” not only leads unfair educational resource allocation , but also causes discrimination in employment because it can be seen that there is a threshold setting of “985” and “211”universities in the recruitment of the selected graduates through empirical analysis . These phenomena violate the principle of fairness on illegal reason . In addition , they also conflict with the legal norms , such as the principle of equality in the Constitution , the prohibiting discrimination in employment terms of the Labor Law , the relevant provisions of the employment equity of the Employment Promotion Law , and the equal competition and the contest mobility of the Civil Servant Law . In a word , the university classification of “985” and “211”deviates from the original intention of the establishment and it should be abolished .

  12. Erzeugung und Folgechemie von Bicyclo[2.1.1]hex-1-ylhalogen- und Bicyclo[2.2.1]hept-1-ylhalogencarbenen

    OpenAIRE

    Dorok, Sascha

    2003-01-01

    Der Zugang zu 1,4-disubstituierten Bicyclo[2.1.1]hexanen konnte verbessert werden. Ausgehend von Cyclopentan-1,3-dicarbonsäuredimethylester konnte Bicyclo[2.1.1]hexan-1,4-dicarbonsäuredimethylester mit Ausbeuten bis zu 58% synthetisiert werden. Hierbei wurde das Bis-Enolat des Diesters in einem Eintopf-Verfahren mit Diiodmethan zweifach alkyliert. Diese Methode zeigt eine hohe Empfindlichkeit gegenüber Veränderungen verschiedener Parameter. Das Verhalten von bicyclo[2.1.1]hexyl-substituierte...

  13. Preoperative CYFRA 21-1 levels as a prognostic factor in c-stage I non-small cell lung cancer

    OpenAIRE

    Suzuki, Hisashi; Ishikawa, Shigemi; Satoh, Hiroaki; Ishikawa, Hiroichi; SAKAI, MITSUAKI; Yamamoto, Tatsuo; Onizuka, Masataka; Sakakibara, Yuzuru

    2007-01-01

    Objective: The clinical importance of preoperative CYFRA 21-1 measurement in early-stage non-small cell lung cancer (NSCLC) is still unclear. The aim of this study is to clarify the prognostic value of preoperative CYFRA 21-1 levels in clinical stage (c-stage) I NSCLC. Methods: The records of 101 c-stage I NSCLC patients who had undergone complete resection were analyzed to correlate preoperative CYFRA 21-1 levels to both the pathologic factors of resected specimens and postoperative outcomes...

  14. A Survey on the E- resource Construction of University Libraries in"211 Project"%“211工程”高校图书馆电子资源网页建设调查

    Institute of Scientific and Technical Information of China (English)

    蒋鸿标

    2011-01-01

    According to the survey on the web pages of 30 libraries of "211 project", the paper puts forward some solutions to the problems of web page designing, column setting, standard of database classification and the list of databases, etc.%对“211工程”高校图书馆中的30所进行网页调查,就其电子资源建设中的网页设计、类目设置、数据库分类标准、数据库列表等方面存在的问题,提出解决办法。

  15. InSb(111)、(211)及(110)晶面腐蚀极性研究%Effect of the polarity of InSb (111),(211) and (110) planes on etching

    Institute of Scientific and Technical Information of China (English)

    马攀; 陈湘伟; 司俊杰

    2009-01-01

    极性是InSb晶体结构的一种属性,文中研究了这种极性对InSb晶片湿法腐蚀的影响,并对这种极性产生的原因进行了分析.结果表明,对于工艺中常用的CP4腐蚀液,(111)及(211)晶面腐蚀时表现出极性,(111)A面平均腐蚀速率为2.2 μm/s,(111)B面的平均腐蚀速率为3.6 μm/s;(211)A面的平均腐蚀速率为3 μm/s,(211)B面的平均腐蚀速率为4.8 μm/s;而(110)晶面在腐蚀时未表现出极性效应,只存在一种腐蚀速率为4 μm/s.

  16. Observation of a narrow structure in the pp elastic scattering at Tkin = 2.11 GeV

    International Nuclear Information System (INIS)

    The angular dependences of the pp elastic scattering analyzing power, spin correlation, depolarization transfer were measured in the angular range from 60 degrees to 97 degrees CM at 14 energies between 1.96 and 2 .23 GeV. At fixed angles two maxima were observed in the analyzing Power energy dependence, both below and above 2.11 GeV. Furthermore a rapid decrease Of the spin correlation Parameter at 90 degrees CM occurs around this energy. The observables allow determination of the absolute values of three nonvanishing pp amplitudes at 90 degrees. The energy dependence of the spin-single amplitude shows a shoulder centered at 2.11 GeV, while the spin-triplet amplitudes are decreasing functions of energy snowing no evidence of structure. All experimental data are listed in tables and their energy dependences are shown in figures

  17. Growth conditions and properties of Y123/Y211 and Y123/Y2O3 bulks

    Science.gov (United States)

    Radušovská, M.; Volochová, D.; Antal, V.; Piovarči, S.; Diko, P.

    2016-03-01

    The single-grain YBCO samples were prepared by TSMG process. Two nominal compositions: 1 mol.Y123 + 0.25 mol.Y2O3 + 1.0 wt.% CeO2 (Y123/Y2O3) or 70 wt.% Y-123 + 30 wt.% Y-211 (Y123/Y211) and 1.0 wt.% CeO2 and two different types of substrates were tested. It is shown that the growth rate in both systems is influenced by segregation of CuO in to the nonsolidified part of the sample what causes stop of isothermal growth. Measured melt losses are lower for ZrO2 substrate than for Y2O3/Yb2O3 substrate what influence final microstructure of prepared bulk superconductors.

  18. Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of {alpha}-particle-emitting {sup 211}At-labeled trastuzumab

    Energy Technology Data Exchange (ETDEWEB)

    Boskovitz, Abraham; McLendon, Roger E.; Okamura, Tatsunori [Department of Pathology, Duke University Medical Center, Durham, NC 27710 (United States); Sampson, John H. [Department of Surgery, Duke University Medical Center, Durham, NC 27710 (United States); Bigner, Darell D. [Department of Pathology, Duke University Medical Center, Durham, NC 27710 (United States); Zalutsky, Michael R. [Department of Radiology, Duke University Medical Center, Durham, NC 27710 (United States)], E-mail: zalut001@mc.duke.edu

    2009-08-15

    Introduction: Carcinomatous meningitis (CM) is a devastating disease characterized by the dissemination of malignant tumor cells into the subarachnoid space along the brain and spine. Systemic treatment with monoclonal antibody (mAb) trastuzumab can be effective against HER2-positive systemic breast carcinoma but, like other therapies, is ineffective against CM. The goal of this study was to evaluate the therapeutic effect of {alpha}-particle emitting {sup 211}At-labeled trastuzumab following intrathecal administration in a rat model of breast carcinoma CM. Methods: Athymic rats were injected intrathecally with MCF-7/HER2-18 breast carcinoma cells through a surgically implanted indwelling intrathecal catheter. In Experiment 1, animals received 33 or 66 {mu}Ci {sup 211}At-labeled trastuzumab, cold trastuzumab or saline. In Experiment 2, animals were inoculated with a lower tumor burden and received 46 or 92 {mu}Ci {sup 211}At-labeled trastuzumab or saline. In Experiment 3, animals received 28 {mu}Ci {sup 211}At-labeled trastuzumab, 30 {mu}Ci {sup 211}At-labeled TPS3.2 control mAb or saline. Histopathological analysis of the neuroaxis was performed at the end of the study. Results: In Experiment 1, median survival increased from 21 days for the saline and cold trastuzumab groups to 45 and 48 days for 33 and 66 {mu}Ci {sup 211}At-labeled trastuzumab, respectively. In Experiment 2, median survival increased from 23 days for saline controls to 68 and 92 days for 46 and 92 {mu}Ci {sup 211}At-labeled trastuzumab, respectively. In Experiment 3, median survival increased from 20 days to 29 and 36 days for animals treated with {sup 211}At-labeled TPS3.2 and {sup 211}At-labeled trastuzumab, respectively. Long-term survivors were observed exclusively in the {sup 211}At-trastuzumab-treated groups. Conclusion: Intrathecal {sup 211}At-labeled trastuzumab shows promise as a treatment for patients with HER2-positive breast CM.

  19. Assessment of confounding factors affecting the tumor markers SMRP, CA125, and CYFRA21-1 in serum

    OpenAIRE

    Daniel Gilbert Weber; Georg Johnen; Dirk Taeger; Anne Weber; Isabelle Mercedes Gross; Beate Pesch; Thomas Kraus; Thomas Brüning; Monika Gube

    2010-01-01

    The purpose of this analysis was to evaluate if serum levels of potential tumor markers for the diagnosis of malignant mesothelioma and lung cancer are affected by confounding factors in a surveillance cohort of workers formerly exposed to asbestos. SMRP, CA125, and CYFRA21-1 concentrations were determined in about 1,700 serum samples from 627 workers formerly exposed to asbestos. The impact of factors that could modify the concentrations of the tumor markers was examined with linear mixed mo...

  20. CYFRA 21-1 in non-small cell lung cancer--standardisation and application during diagnosis

    OpenAIRE

    Pavićević, Radomir; Bubanović, Gordana; Franjević, Ana; Stančić-Rokotov, Dinko; Samaržija, Miroslav

    2008-01-01

    There is no ideal tumour marker at present. The clinical application of CYFRA 21-1 is possible once a thorough standardisation process is carried out. Standardisation is achieved by determining the reference range in asymptomatic population, benign and malignant lung diseases, and benign and malignant diseases of other organs. Furthermore, it depends on knowledge of research population characteristics, patient medical histories and individual diagnostic procedure results, the size...

  1. Engineer/constructor description of work for Tank 241-SY-102 retrieval system, project W-211, initial tank retrieval systems

    International Nuclear Information System (INIS)

    This document provides a description of work for the design and construction of a waste retrieval system for Tank 241-SY-102. The description of work includes a working estimate and schedule, as well as a narrative description and sketches of the waste retrieval system. The working estimate and schedule are within the established baselines for the Tank 241-SY-102 retrieval system. The technical baseline is provided in Functional Design Criteria, WHC-SD-W211-FDC-001, Revision 2

  2. Engineer/constructor description of work for Tank 241-SY-102 retrieval system, project W-211, initial tank retrieval systems

    Energy Technology Data Exchange (ETDEWEB)

    Rieck, C.A. [Westinghouse Hanford Co., Richland, WA (United States)

    1996-02-01

    This document provides a description of work for the design and construction of a waste retrieval system for Tank 241-SY-102. The description of work includes a working estimate and schedule, as well as a narrative description and sketches of the waste retrieval system. The working estimate and schedule are within the established baselines for the Tank 241-SY-102 retrieval system. The technical baseline is provided in Functional Design Criteria, WHC-SD-W211-FDC-001, Revision 2.

  3. Diagnostic Significance of Combining Telomerase Activity with CYFRA21-1 Level in Differentiating Malignant Pleural Effusion Caused by Lung Cancer from Benign Pleural Effusio

    OpenAIRE

    Li, Hongmei; Junhua FU; Yuande XIU; Zhou, Qinghua

    2010-01-01

    Background and objective Telomerase and CYFRA21-1 may be positively expressed in malignant pleural effusion, but the sensitivity and specificity of single tumor marker were low. The aim of this study is to investigate the diagnostic value of combining determination of telomerase activity and CYFRA21-1 levels in differentiating benign from malignant pleural effusion caused by lung cancer. Methods 80 patients with malignant and 50 patients with benign pleural effusion were enrolled into this st...

  4. Cyfra 21-1 as a serum tumor marker for follow up of patients with laryngeal and hypopharyngeal squamous cell carcinoma

    OpenAIRE

    Al-Shagahin, Hani

    2010-01-01

    AIM: To evaluate the importance and potential of Cyfra21-1 as a tumor marker (TM) for follow-up of patients with squamous cell carcinoma (SCC) in laryngeal and hypopharyngeal cancer. PATIENTS AND METHODS: Cyfra21-1 serum levels of 50 patients with laryngeal and hypopharyngeal SCC were evaluated by ECLIA assay. Statistical analysis was performed using Kruskal-Wallis and Jonckheere-Terpstra tests. RESULTS: There was no significant c...

  5. Cytokeratin 19-fragments (CYFRA 21-1) as a novel serum biomarker for response and survival in patients with advanced pancreatic cancer

    OpenAIRE

    Boeck, S.; Wittwer, C; Heinemann, V; Haas, M.; Kern, C; Stieber, P; Nagel, D; Holdenrieder, S

    2013-01-01

    Background: CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. Methods: Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measurements of CYFRA 21-1, carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (assessed by Elecsys 2010, Roche Diagnostics) during palliative first-line chemotherapy we...

  6. 流式荧光法在检测肺癌患者血清cyfra 21-1中的应用

    Institute of Scientific and Technical Information of China (English)

    徐阳(飚); 吴传勇; 吴京; 娄加陶

    2012-01-01

    目的 探讨流式荧光法检测血清cyfra 21-1的临床应用价值.方法 比较流式荧光法与电化学发光法检测血清cyfra21-1水平的相关性,设定本实验室流式荧光法检测血清cyfra 21-1诊断肺癌的cut off值并进行评价.结果 流式荧光法检测血清cyfra 21-1水平结果与电化学发光法显著相关(r=0.989,P<0.05);流式荧光法检测血清cyfra 21-1的cut off值为5.36ng/mL,高于厂商提供的值5.0 ng/mL;肺癌患者血清cyfra 21-1阳性率为66.0%,其中鳞癌为77.8%,腺癌69.7%、小细胞癌19.2%.Ⅲ、Ⅳ期肺癌患者血清cyfra 21-1水平显著高于Ⅰ、Ⅱ期,P均<0.05.结论 流式荧光法检测血清cyfra 21-1对非小细胞肺癌有一定的辅助诊断价值.

  7. Variations in Serum CEA and CYFRA21-1 Levels Before and After Surgery Facilitate Prognosis of Non-small Cell Lung Cancer Patients

    OpenAIRE

    Xinchun DUAN; Cui, Yong; Gong, Min; Tian, Feng; Guan SHI; Wu, Bingqun; Liu, Mingliang; Jiayun GUO; Kong, Yuanyuan

    2015-01-01

    Background and objective Serum carcinoembryonic antigen (CEA) and the soluble fragment of cytokeratin 19 (CYFRA21-1) are important tumor markers (TMs) in the preoperative examination of patients with non-small cell lung cancer (NSCLC). However, the prognostic role of these markers in NSCLC patients remains controversial. The aim of the study was to investigate the clinical significance of serum CEA variances and CYFRA21-1 levels for the prognosis of NSCLC patients following surgery. Methods T...

  8. 5 CFR 892.211 - What options are available to me if I go on a period of leave without pay (LWOP) or other types...

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What options are available to me if I go on a period of leave without pay (LWOP) or other types of non-pay status? 892.211 Section 892.211... What options are available to me if I go on a period of leave without pay (LWOP) or other types of...

  9. Axial, Scalar and Tensor Charges of the Nucleon from 2+1+1-flavor Lattice QCD

    CERN Document Server

    Bhattacharya, Tanmoy; Cohen, Saul; Gupta, Rajan; Lin, Huey-Wen; Yoon, Boram

    2016-01-01

    We present results for the isovector axial, scalar and tensor charges $g^{u-d}_A$, $g^{u-d}_S$ and $g^{u-d}_T$ of the nucleon needed to probe the Standard Model and novel physics. The axial charge is a fundamental parameter describing the weak interactions of nucleons. The scalar and tensor charges probe novel interactions at the TeV scale in neutron and nuclear $\\beta$-decays, and the flavor-diagonal tensor charges $g^{u}_T$, $g^{d}_T$ and $g^{s}_T$ are needed to quantify the contribution of the quark electric dipole moment (EDM) to the neutron EDM. The lattice-QCD calculations were done using nine ensembles of gauge configurations generated by the MILC Collaboration using the HISQ action with 2+1+1 dynamical flavors. These ensembles span three lattice spacings $a \\approx 0.06, 0.09$ and $0.12$ fm and light-quark masses corresponding to the pion masses $M_\\pi \\approx$ 135, 225 and 315 MeV. High-statistics estimates on five ensembles using the all-mode-averaging method allow us to quantify all systematic unce...

  10. Evaluation of a new tumor marker, CYFRA 21-1, in patients with primary lung cancer

    International Nuclear Information System (INIS)

    We measured the level of serum CYFRA 21-1 (CYFRA) in 38 primary lung cancer patients (21 adenocarcinomas (ACs), 12 squamous cell carcinomas (SqCCs) and 5 small cell carcinomas (SmCCs)) before undergoing therapy using a 'CYFRA immunoradiometric assay kit'. We thus determined the CYFRA cut-off level to be 1.7 ng/ml. We also measured both the carcinoembryonic antigen (CEA), and the squamous cell carcinoma antigen (SCC) levels. The positive rate for CYFRA in patients with lung cancer was 71% and such positivity was related to their histology (SqCCs, SmCCs 100%; ACs 48%). The level of CYFRA was significantly higher in SqCCs than in either ACs or SmCCs. No significant differences were observed in the serum CYFRA value among the various clinical stages. In addition, no significant correlation was seen between CYFRA and SCC, or between CYFRA and CEA. Among the various clinical stages of SqCCs, the positive rate of CYFRA was higher in the early clinical stages than in SCC. Our findings therefore support the usefulness of CYFRA as a marker of SqCCs. (author)

  11. ART: Surveying the Local Universe at 2-11 keV

    Science.gov (United States)

    O'Dell, S. L.; Ramsey, B. D.; Adams, M. L.; Brandt, W. N.; Bubarev, M. V.; Hassinger, G.; Pravlinski, M.; Predehl, P.; Romaine, S. E.; Swartz, D. A.; Urry, C. M.; Vikhlinin, A.; Weisskopf, M. C.

    2008-01-01

    The Astronomical Rontgen Telescope (ART) is a medium-energy x-ray telescope system proposed for the Russian-led mission Spectrum Rontgen-Gamma (SRG). Optimized for performance over the 2-11-keV band, ART complements the softer response of the SRG prime instrument-the German eROSITA x-ray telescope system. The anticipated number of ART detections is 50,000-with 1,000 heavily-obscured (N(sub H)> 3x10(exp 23)/sq cm) AGN-in the SRG 4-year all-sky survey, plus a comparable number in deeper wide-field (500 deg(sup 2) total) surveys. ART's surveys will provide a minimally-biased, nearly-complete census of the local Universe in the medium-energy x-ray band (including Fe-K lines), at CCD spectral resolution. During long (approx.100-ks) pointed observations, ART can obtain statistically significant spectral data up to about 15 keY for bright sources and medium-energy x-ray continuum and Fe-K-line spectra of AGN detected with the contemporaneous NuSTAR hard-x-ray mission.

  12. Evaluation of a new tumor marker, CYFRA 21-1, in patients with primary lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Tsuyoshi; Ichiya, Yuichi; Kuwabara, Yasuo [Kyushu Univ., Fukuoka (Japan). Faculty of Medicine] [and others

    1996-04-01

    We measured the level of serum CYFRA 21-1 (CYFRA) in 38 primary lung cancer patients (21 adenocarcinomas (ACs), 12 squamous cell carcinomas (SqCCs) and 5 small cell carcinomas (SmCCs)) before undergoing therapy using a `CYFRA immunoradiometric assay kit`. We thus determined the CYFRA cut-off level to be 1.7 ng/ml. We also measured both the carcinoembryonic antigen (CEA), and the squamous cell carcinoma antigen (SCC) levels. The positive rate for CYFRA in patients with lung cancer was 71% and such positivity was related to their histology (SqCCs, SmCCs 100%; ACs 48%). The level of CYFRA was significantly higher in SqCCs than in either ACs or SmCCs. No significant differences were observed in the serum CYFRA value among the various clinical stages. In addition, no significant correlation was seen between CYFRA and SCC, or between CYFRA and CEA. Among the various clinical stages of SqCCs, the positive rate of CYFRA was higher in the early clinical stages than in SCC. Our findings therefore support the usefulness of CYFRA as a marker of SqCCs. (author).

  13. The Neutron Electric Dipole Moment using $N_f{=}2{+}1{+}1$ twisted mass fermions

    CERN Document Server

    Alexandrou, C; Constantinou, M; Hadjiyiannakou, K; Jansen, K; Koutsou, G; Ottnad, K; Petschlies, M

    2015-01-01

    We evaluate the neutron electric dipole moment $\\vert\\vec{d}_N\\vert$ using lattice QCD techniques. The gauge configurations analysed are produced by the European Twisted Mass Collaboration using $N_f{=}2{+}1{+}1$ twisted mass fermions at one value of the lattice spacing of $a \\simeq 0.082 \\ {\\rm fm}$ and a light quark mass corresponding to $m_{\\pi} \\simeq 373 \\ {\\rm MeV}$. Our approach to extract the neutron electric dipole moment is based on the calculation of the $CP$-odd electromagnetic form factor $F_3(Q^2)$ for small values of the vacuum angle $\\theta$ in the limit of zero Euclidean momentum transfer $Q^2$. The limit $Q^2 \\to 0$ is realised either by adopting a parameterization of the momentum dependence of $F_3(Q^2)$ and performing a fit, or by employing new position space methods, which involve the elimination of the kinematical momentum factor in front of $F_3(Q^2)$. The computation in the presence of a $CP$-violating term requires the evaluation of the topological charge ${\\cal Q}$. This is computed ...

  14. Overexpression of a maize SNF-related protein kinase gene, ZmSnRK2.11, reduces salt and drought tolerance in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    ZHANG Fan; CHEN Xun-ji; WANG Jian-hua; ZHENG Jun

    2015-01-01

    Sucrose non-fermenting-1 related protein kinase 2 (SnRK2) is a unique family of protein kinases associated with abiotic stress signal transduction in plants. In this study, a maize SnRK2 gene ZmSnRK2.11 was cloned and characterized. The results showed that ZmSnRK2.11 is up-regulated by high-salinity and dehydration treatment, and it is expressed mainly in maize mature leaf. A transient expression assay using onion epidermal cel s revealed that ZmSnRK2.11-GFP fusion proteins are localized to both the nucleus and cytoplasm. Overexpressing-ZmSnRK2.11 in Arabidopsis resulted in salt and drought sensitivity phenotypes that exhibited an increased rate of water loss, reduced relative water content, delayed stoma closure, accumulated less free proline content and increased malondialdehyde (MDA) content relative to the phenotypes observed in wild-type (WT) control. Furthermore, overexpression of ZmSnRK2.11 up-regulated the expression of the genes ABI1 and ABI2 and decreased the expression of DREB2A and P5CS1. Taken together, our results suggest that ZmSnRK2.11 is a possible negative regulator involved in the salt and drought stress signal transduction pathways in plants.

  15. Study of a new tumor marker, CYFRA 21-1, in squamous cell carcinoma of the cervix, and comparison with squamous cell carcinoma antigen

    International Nuclear Information System (INIS)

    The diagnosis value of a new tumor marker, CYFRA 21-1, was studied in the blood samples collected from 22 controls, and 87 pre-treatment patients with squamous cell carcinoma of the cervix. Sensitivity and specificity of CYFRA 21-1 was was compared with those of squamous cell carcinoma antigen (SCC) measured in the sera of the same patients. Serum CYFRA 21-1 levels were higher in patients with squamous cell carcinoma than in controls (p < 0.05), and correlated with FIGO stage (Stage IIb-IV vs. Stage Ib-IIa, p = 0.0477). Using 2.5 ng/ml as cut-off value, elevated CYFRA 21-1 levels were found in 13.6% of controls, 34.8% of patients with Stage Ib-IIa squamous cell carcinoma of the cervix, and 63.5% of patients with Stage IIb-IV squamous cell carcinoma of the cervix. However, there was less sensitivity and specificity of CYFRA 21-1 than those of SCC in detecting squamous cell carcinoma of the cervix. CYFRA 21-1 may not be a better tumor marker than SCC for squamous cell carcinoma of the cervix. (author)

  16. The near-infrared excitation of the HH 211 protostellar outflow

    Science.gov (United States)

    O'Connell, B.; Smith, M. D.; Froebrich, D.; Davis, C. J.; Eislöffel, J.

    2005-02-01

    The protostellar outflow HH 211 is of considerable interest since it is extremely young and highly collimated. Here, we explore the outflow through imaging and spectroscopy in the near-infrared to determine if there are further diagnostic signatures of youth. We confirm the detection of a near-infrared continuum of unknown origin. We propose that it is emitted by the driving millimeter source, escapes the core through tunnels, and illuminates features aligning the outflow. Narrow-band flux measurements of these features contain an unusually large amount of continuum emission. [FeII] emission at 1.644 μm has been detected and is restricted to isolated condensations. However, the characteristics of vibrational excitation of molecular hydrogen resemble those of older molecular outflows. We attempt to model the ordered structure of the western outflow as a series of shocks, finding that bow shocks with J-type dissociative apices and C-type flanks are consistent. Moreover, essentially the same conditions are predicted for all three bows except for a systematic reduction in speed and density with distance from the driving source. We find increased K-band extinctions in the bright regions as high as 2.9 mag and suggest that the bow shocks become visible where the outflow impacts on dense clumps of cloud material. We propose that the outflow is carved out by episodes of pulsating jets. The jets, driven by central explosive events, are responsible for excavating a central tunnel through which radiation temporarily penetrates. Based in part on observations collected at the German-Spanish Astronomical Center, Calar Alto, operated jointly by Max-Planck Institut für Astronomie and Instituto de Astrofísica de Andalucía (CSIC). Observations were also obtained with The United Kingdom Infrared Telescope, which is operated by the Joint Astronomy Centre on behalf of the UK Particle Physics and Astronomy Research Council.

  17. Fabrication of YBCO film approached by the '211 process' in the TFA-MOD method

    International Nuclear Information System (INIS)

    We fabricated YBCO film using a new approach to the TFA-MOD method. In the fabrication process, Y2Ba1Cu1Ox and Ba3Cu5O8 powders were used as precursors (the so called '211 process'), instead of Y-, Ba-, and Cu-based acetates, and dissolved in trifluoroacetic acid followed by calcining and firing heat treatment. Consequently, we successfully synthesized YBCO film and evaluated the phase formation, texture evolution, and critical properties as a function of the calcining and firing temperature and humidity, in order to explore its possible application in coated conductor fabrication. The films were calcined at 430-460 deg. C and then fired at 750-800 deg. C in a 0-20% humidified Ar-O2 atmosphere. We observed that the amount of BaF2 phase was effectively reduced and that a sharp and strong biaxial texture formed under a humidified atmosphere, leading to increased critical properties. In addition, we found that the microstructure varied significantly with the firing temperature; the grains grew further, the film became denser, and the degree of texture and phase purity varied as the firing temperature increased. For the film fired at 775 deg. C after calcining at 460 deg. C, the critical current was found to be 39 A cm-1 width (the corresponding critical current density is 2.0 MA cm-2), which was probably attributable to such factors as the enhanced phase purity and out-of-plane texture, the moderate film density and grain size, and the crack-free surface

  18. Project Management Plan for Initial Tank Retrieval Systems, Project W-211

    International Nuclear Information System (INIS)

    Project W-211, Initial Tank Retrieval Systems (ITRS), is a fiscal year 1994 Major Systems Acquisition that will provide systems for retrieval of radioactive wastes from selected double-shell tanks (DST). The contents of these tanks are a combination of supernatant liquids and settled solids. To retrieve waste from the tanks, it is first necessary to mix the liquid and solids prior to transferring the slurry to alternative storage or treatment facilities. The ITRS will provide systems to mobilize the settled solids and transfer the wastes out of the tanks. In so doing, ITRS provides feed for future processing plants, allows for consolidation of tank solids to manage space within existing DST storage capacity, and supports continued safe storage of tank waste. The ITRS scope has been revised to include waste retrieval systems for tanks AP-102, AP-104, AP-108, AN-103, AN-104, AN-105, AY-102, AZ-102, and SY-102. This current tank selection and sequence provides retrieval systems supporting the Privatized waste processing plant and sustains the ability to provide final remediation of several watch list DSTs via treatment. The ITRS is configured to support changing program needs, as constrained by available budget, by maintaining the flexibility for exchanging tanks requiring mixer pump-based retrieval systems and shifting the retrieval sequence. Preliminary design was configured such that an adequate basis exists for initiating Title II design of a mixer pump based retrieval system for any DST. This Project Management Plan (PMP) documents the methodology for managing the ITRS, formalizes organizational responsibilities and interfaces, and identifies project requirements such as change control, design verification, systems engineering, and human factors engineering

  19. Development of MBE II-VI Epilayers on GaAs(211)B

    Science.gov (United States)

    Jacobs, R. N.; Nozaki, C.; Almeida, L. A.; Jaime-Vasquez, M.; Lennon, C.; Markunas, J. K.; Benson, D.; Smith, P.; Zhao, W. F.; Smith, D. J.; Billman, C.; Arias, J.; Pellegrino, J.

    2012-10-01

    Large-area, low-cost substrates are envisioned for next-generation HgCdTe infrared focal-plane arrays (IRFPA). Si, GaAs, Ge, and InSb have been previously examined as potential candidates. Fabrication of IRFPAs based on these substrates is limited by fundamental materials properties that potentially lead to lower detector performance and operability. Lattice and thermal mismatch between the substrate and epilayer are just two of several material factors that must be considered. We have reviewed these factors in the context of more recent data, and determined it worthwhile to revisit the use of GaAs substrates for epitaxial growth of HgCdTe. Our study starts with an evaluation of the surface quality (epireadiness) of commercially available (211) B-oriented GaAs substrates. Molecular beam epitaxial growth of CdTe buffer layers and subsequent HgCdTe absorber layers are performed in separate vacuum-interconnected chambers. The importance of optimization of the CdTe buffer layer growth for high-quality HgCdTe is detailed through surface morphology and x-ray studies. x-Ray diffraction rocking-curve full-width at half-maximum values as low as 52 arcsec have been obtained. Long-wave infrared Hg1- x Cd x Te ( x = 0.23) has been grown on these buffer layers, producing cross-hatch-dominated surface morphologies, with dislocation densities as low as ˜3 × 106 cm-2. We have also obtained (for optimized layers), 80-K Hall-effect n-type carrier concentration and electron mobility of approximately ~1.5 × 1015 cm-3 and 1 × 105 cm2 V-1 s-1, respectively. Finally, we briefly compare GaAs and Si in light of our preliminary investigation.

  20. Neutron electric dipole moment using N{sub f}=2+1+1 twisted mass fermions

    Energy Technology Data Exchange (ETDEWEB)

    Alexandrou, C.; Athenodorou, A.; Constantinou, M.; Hadjiyiannakou, K. [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics; The Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Jansen, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Koutsou, G. [The Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Ottnad, K. [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics; Bonn Univ. (Germany). Helmholtz-Institut fuer Strahlen- und Kernphysik; Bonn Univ. (Germany). Bethe Center for Theoretical Physics; Petschlies, M. [The Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Bonn Univ. (Germany). Helmholtz-Institut fuer Strahlen- und Kernphysik; Bonn Univ. (Germany). Bethe Center for Theoretical Physics

    2016-03-15

    We evaluate the neutron electric dipole moment vertical stroke vector d{sub N} vertical stroke using lattice QCD techniques. The gauge configurations analyzed are produced by the European Twisted Mass Collaboration using N{sub f}=2+1+1 twisted mass fermions at one value of the lattice spacing of a ≅0.082 fm and a light quark mass corresponding to m{sub π}≅373 MeV. Our approach to extract the neutron electric dipole moment is based on the calculation of the CP-odd electromagnetic form factor F{sub 3}(Q{sup 2}) for small values of the vacuum angle θ in the limit of zero Euclidean momentum transfer Q{sup 2}. The limit Q{sup 2}→0 is realized either by adopting a parameterization of the momentum dependence of F{sub 3}(Q{sup 2}) and performing a fit, or by employing new position space methods, which involve the elimination of the kinematical momentum factor in front of F{sub 3}(Q{sup 2}). The computation in the presence of a CP-violating term requires the evaluation of the topological charge Q. This is computed by applying the cooling technique and the gradient flow with three different actions, namely the Wilson, the Symanzik tree-level improved and the Iwasaki action. We demonstrate that cooling and gradient flow give equivalent results for the neutron electric dipole moment. Our analysis yields a value of vertical stroke vector d{sub N} vertical stroke =0.045(6)(1) anti θ e.fm for the ensemble with m{sub π}=373 MeV considered.

  1. 血清CEA和CYFRA 21-1对非小细胞肺癌的诊断价值

    Institute of Scientific and Technical Information of China (English)

    高文静; 黎灼滔; 钟方毅; 曾淑敏

    2014-01-01

    目的:研究血清癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA 21-1)对非小细胞肺癌的诊断价值。方法随机筛选广东省东莞市莞城医院住院患者血清标本,将35例非小细胞肺癌患者作为观察组,35例良性肺部疾病患者作为对照组,对两组患者的血清CEA和CYFRA 21-1进行电化学免疫检测。结果观察组患者的血清CEA和CYFRA 21-1两种指标的平均水平明显高于对照组,其中观察组CEA指标为(17.15±6.28)μg/L、CYFRA 21-1指标为(14.07±8.64)μg/L;对照组CEA指标为(3.51±1.17)μg/L、CYFRA 21-1指标为(2.61±2.184)μg/L。CYFRA 21-1对非小细胞肺癌的敏感性较高,而CEA对该病的特异性较高,两种指标联合诊断的敏感性明显增高,其中关于敏感度的检测,CEA检测为10例(28.57%),CYFRA 21-1检测为24例(68.57%),两者联合检测为29例(82.86%);关于特异性的检测,CEA检测为34例(97.14%),CYFRA 21-1检测为27例(77.14%),两者联合检测为21例(60.00%)差异均有统计学意义(均P<0.05)。结论 CEA和CYFRA 21-1联合检测用于非小细胞肺癌,具有较好的敏感性及特异性,可为临床诊断提供参考。%Objective To explore the diagnostic value of carcinoembryonic antigen and Cytokeratin 19 fragment in serum for non-small cell lung cancer (NSCLC). Methods 35 cases of patients with NSCLC were as observation group and 35 cases of person with benign lung disease were as control group. CEA and CYFRA 21-1 in serum of two groups were detected with ECLIA. Results CEA and CYFRA 21-1 in observation group was obviously higher than that in control group, CEA showed higher speciifcity and CYFRA 21-1 showed higher susceptibility for NSCLC, the CEA combined with CYFRA 21-1 showed higher susceptibility. The above-mentioned date showed signiifcant difference(P<0.05). Conclusion The CEA combined with CYFRA 21-1 used for NSCLC are good susceptibility and

  2. High preoperative and postoperative levels of carcinoembryonic antigen and CYFRA 21-1 indicate poor prognosis in patients with pathological Stage I nonsmall cell lung cancer

    Directory of Open Access Journals (Sweden)

    X Duan

    2015-01-01

    Full Text Available BACKGROUND: Serum carcinoembryonic antigen (CEA and the soluble fragment of cytokeratin 19 (CYFRA 21-1 are supposed to have a prognostic role in patients with nonsmall cell lung cancer (NSCLC after surgery, but it has not been used as an adjunct to the tumor-node-metastasis (TNM staging system to provide therapy options for patients with pathological Stage I NSCLC. This study was designed to investigate the effect of serum levels of CEA and CYFRA 21-1 before and after surgery on the prognosis of patients with Stage I NSCLC. MATERIALS AND METHODS: A retrospective review was performed regarding the medical records and follow-ups of 169 patients with Stage I NSCLC before and after surgery. The patients were divided into three groups based on levels of serum CEA and CYFRA 21-1 before and after surgery: (1 continuously normal-level groups (CEA [NN] and CYFRA 21-1 [NN] groups; (2 declined to normal-level groups (CEA [HN] and CYFRA 21-1 [HN] groups; and (3 continuously high-level groups (CEA [HH] and CYFRA 21-1 [HH] groups. Survival analysis was conducted using the Kaplan-Meier method for each group. The Chi-square or Fisher exact test was employed to compare clinical and pathologic factors at the level of P < 0.05. The prognostic factor was evaluated by the Cox proportional hazards model. RESULTS: Compared with the continuously normal-level groups, the CEA [HN] group was significantly correlated to tumor size (P = 0.011, and the CYFRA 21-1 [HN] group was significantly correlated to tumor type and pathological TNM in addition to tumor size. Five-year survivals were significantly lower (P = 0.004 in the CEA [HH] group (67.3% and the CEA [HN] group (86.5% than in the CEA [NN] group (85.7% and were significantly lower (P < 0.001 in the CYFRA 21-1 [HH] group (47.2% and the CYFRA 21-1 [HN] group (70.1% than in the CYFRA 21-1 [NN] group (90.1%. Multivariate analysis demonstrated that tumor size (21-50 mm, CEA [HH], and CYFRA 21-1 [HH] were independent

  3. Clinical value of CEA and CYFRA 21-1 for the differentiation of benign and malignant pleural effusion by Meta analysis

    International Nuclear Information System (INIS)

    Objective: Pleural effusion is a common clinical complication caused by many benign or malignant diseases. Many published papers presented that tumor-marker assays, such as carcinoembryonic antigen (CEA) and cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1), played a vital role on the benign and malignant differentiation. This study aimed to reviewe currently available published papers to evaluate the clinical value of these two markers for the differentiation of benign and malignant pleural effusion. Methods: All published data of pleural effusion CEA and CYFRA 21-1 for the differentiation studies from year 1996 to 2007 were reviewed. By methodological qualities and Q test, 19 papers were selected into this study. The overall diagnostic sensitivity, specificity, and area under curve (AUC) from receiver operating characteristic (ROC) curve were adopted to compare the value of pleural effusion CEA and CYFRA 21-1 for benign and malignant differentiation used Z test. Results: There were 3228 subjects included in this Meta-analysis. The sensitivity and specificity [95% confidence interval (CI)] of CEA were 45.9% (43.2%-48.5%) and 97.0% (96.0%-97.8%), and of CYFRA 21-1, 47.3% (44.0%-50.6%) and 91.8% (89.5%-93.7%). AUC of CEA and CYFRA 21-1 were 0.7691 and 0.8213 respectively (Z=0.45, P>0.05). Conclusion: Both CEA and CYFRA 21-1 are useful for the differentiation of benign and malignant pleural effusion. (authors)

  4. 血清TAM、SCC和CYFRA 21-1联合检测在食管鳞癌诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    刘玉含; 刘红春

    2014-01-01

    目的 探讨血清TAM、SCC和CYFRA 21-1联合检测在食管鳞癌诊断中的价值.方法 分别采用生化比色法和化学发光法分别检测48例食管鳞癌患者、53例慢性食管炎患者和50例健康对照者血清中TAM、SCC和CYFRA 21-1水平.结果 食管鳞癌组血清TAM、SCC和CYFRA 21-1水平均高于慢性食管炎疾病组和健康对照组(P<0.05).食管炎组血清TAM水平高于健康对照组(P<0.05),而CYFRA 21-1和SCC水平在两组间比较,差异无统计学意义(P>0.05).TAM、SCC和CYFRA 21-1联合检测的敏感性明显高于TAM、SCC和CYFRA 21-1单独检测(P<0.05),但特异性比较无统计学意义(P>0.05).结论 TAM、SCC和CYFRA 21-1水平在食管鳞癌患者中明显升高,三者联合检测有利于提高食管鳞癌诊断的敏感性.

  5. Comparison Study of Cyfra 21-1, Carcinoembryonic Antigen and Telomerase Activity between Non Small Cell and Small Cell Lung Cancer Patients

    Directory of Open Access Journals (Sweden)

    B. Alani

    2008-10-01

    Full Text Available Introduction & Objective: The roles of tumor markers in the prognosis and diagnosis of lung cancer is under investigation. The aim of this study was to examine correlation between serum levels of Carcinoembryonic Antigen (CEA and Cyfra 21-1 with telomerase activity on biopsy samples in patients with lung cancer and controls.Materials & Methods: We studied 50 malignant lung cancer patients (mean age 68.3±13.8 years and 20 normal individuals (mean age 64.9±11.4 years. Serum levels of Cyfra21-1 and CEA were measured with available enzyme immunoassay kits. Telomerase activity was measured by TRAP assay based on PCR-ELISA in lung tumor biopsy. To compare quantitative means of the two groups, t-independent and Man-Whitney analysis were applied.Results: The mean serum levels of CEA and Cyfra21-1 concentration together telomerase activity of biopsy samples in lung cancer patients were significantly higher than controls. There were a strong correlation between Cyfra21-1 and CEA, Telomerase and CEA and Telomerase and Cyfra21-1 in patient group. In patients with small cell carcinoma, the mean serum levels of Cyfra21-1 and CEA were significantly higher than non small cell carcinoma patients. Telomerase activities in biopsy samples of small cell carcinoma were significantly lower than non small cell carcinoma patients.Conclusion: It is speculated that based on this findings, telomerase activity in biopsy samples for small cell carcinoma patients and serum levels of Cyfra 21-1 and CEA are the most useful tumor markers for diagnosis of squamous and adenocarcinoma of non small cell cancers respectively.

  6. Diagnostic Significance of Combining Telomerase Activity with CYFRA21-1 Level in Differentiating Malignant Pleural Effusion Caused by Lung Cancer from Benign Pleural Effusio

    Directory of Open Access Journals (Sweden)

    Hongmei LI

    2010-06-01

    Full Text Available Background and objective Telomerase and CYFRA21-1 may be positively expressed in malignant pleural effusion, but the sensitivity and specificity of single tumor marker were low. The aim of this study is to investigate the diagnostic value of combining determination of telomerase activity and CYFRA21-1 levels in differentiating benign from malignant pleural effusion caused by lung cancer. Methods 80 patients with malignant and 50 patients with benign pleural effusion were enrolled into this study. The telomerase activity in pleural effusion was tested by means of telomeric repeat amplification protocal-PCR-ELISA (TRAP-PCR-ELISA and CYFRA21-1 levels were tested by the EIA method. All the results were analyzed by the statistical method. Results The levels of telomerase and CYFRA21-1 in malignant pleural effusion was significantly higher than that in benign one (t =17.252 and t =13.951, P<0.001. The sensitivity of telomerase activity testing for diagnosing malignant pleural effusion was 71.3%; the specificity was 86.0% and the overall accuracy was 76.9%. The sensitivity of CYFRA 21-1 testing was 60.0%, the specificity was 78.0% and the overall accuracy was 66.9%. The sensitivity of the combined testing was 90.0%, the specificity was 76.0% and the overall accuracy was 86.9%. The sensitivity and the overall accuracy of combined testing were higher than those of telomerase and CYFRA21-1 testing single(χ2=9.002 and χ2=19.201, P<0.01; χ2=4.389 and χ2=14.647, P<0.05. Conclusion The combined testing of telomerase with CYFRA21-1 can increase the sensitivity and overall accuracy of differential diagnosis of benign and malignant pleural effusion diagnosis.

  7. YT211系列硫醇甲基锡热稳定剂在硬质聚氯乙烯加工中的应用%Application of YT211 Series Methyltin Mercaptide Heat Stabilizers in Rigid PVC Processing

    Institute of Scientific and Technical Information of China (English)

    易强顺

    2016-01-01

    测试了YT1211系列硫醇甲基锡热稳定剂在聚氯乙烯(PVC)加工过程中的动态热稳定性能和流变性能.结果表明,与181型硫醇甲基锡相比,YT211具有较好的动态热稳定性能和加改善工功能,尤其适宜于高端硬质PVC制品的加工.

  8. Assessment of Serum TSGF, NSE and CYFRA-21-1 in Lung Cancer%TSGF、NSE和CYFRA-21-1联合检测在肺癌诊治中的应用

    Institute of Scientific and Technical Information of China (English)

    李有武; 夏永祥; 王卫文

    2003-01-01

    目的:探讨TSGF、NSE和CYFRA-21-13种血清肿瘤标志物单独及联合检测在肺癌诊断、手术治疗效果评价及转移复发监测中的应用价值;方法:显色法测定TSGF、酶联免疫吸附法测定NSE和放射免疫法测定CYFRA-21-1,共测定50例健康成人及36例不同分型的肺癌患者的血清标本,并对其中24例患者进行了术后3个月~2年的随访监测.结果:健康人组TSGF为53.7±5.7U/mL,NSE为2.7±0.7ng/mL,CYFRA-21-1为1.4±0.8μg/mL.肺癌患者各型3项血清肿瘤标志物中的任何一项均较健康人组有显著增高(P<0.05),其敏感性与病理分型相关.术前TSGF为76.4±7.6U/mL,NSE为15.2±6.1ng/mL,CYFRA-21-1为11.2±8.6μg/m,术后3项肿瘤标志物检测的数值较术前的明显下降(P<0.05);而当术后转移复发时明显增高,与术前差异无显著意义(P>0.05).3项血清肿瘤标志物经组合后,敏感性显著提高.结论:TSGF、NSE和CYFRA-21-1对肺癌的诊断、疗效判断及转移或复发监测有意义.TSGF、CYFRA-21-1二者联合检测可作为鳞癌诊治的首选标志.TSGF、NSE二者联合检测可作为小细胞性肺癌首选指标.

  9. CyFRA21-1 the expression in patients with bladder cancer research%CyFRA21-1在膀胱癌患者中的表达研究

    Institute of Scientific and Technical Information of China (English)

    王兴亮; 宋明山

    2012-01-01

    目的 研究尿细胞角蛋白CYFRA 2l-1在膀胱癌中的表达.方法 选择我院2011年12月至2012年5月32例经病理确诊的膀胱癌作为观察组,32例膀胱良性病变患者作为良性组,同时选择同期健康体检者32例为对照组,均取晨尿,对3组CYFRA 21-l进行检测,对CYFRA 21-l表达进行研究,同时对观察组患者不同病理分期、治疗前后CYFRA 2l-1变化情况进行观察.结果 观察组为(29.52±18.33)ng/ml,良性组为(4.47±2.33)ng/ml,观察组CYFRA21-1大大高于良性组与对照组,对照组CYFRA21-1高于正常组,组间比较差异具有显著性,有统计学意义(P<0.05),浅表性膀胱癌CYFRA21-1检测值为(8.49±2.21)ng/ml,大大低于浸润性膀胱癌,两组比较差异具有显著性,有统计学意义(P<0.05),经手术、膀胱灌洗、放疗、化疗等治疗后,浅表性膀胱癌组CYFRA21-1下降明显,接近临界值,与治疗前比较差异具有显著性,有统计学意义(P<0.05),浸润性膀胱癌患者治疗后较治疗前略有下降,但下降幅度不大.结论 尿CYFRA 2l-l检测对膀胱癌的诊断及预后判定均有较高的临床价值.

  10. The translocation t(2;11)(p21;q23) without MLL gene rearrangement--a possible marker of good prognosis in myelodysplastic syndrome patients.

    Science.gov (United States)

    Dvorak, Pavel; Lysak, Daniel; Vokurka, Samuel; Michalova, Kyra; Sarova, Iveta; Jonasova, Anna; Hruba, Martina; Rykovska, Anna; Subrt, Ivan

    2014-06-01

    The translocation t(2;11)(p21;q23) is associated with de novo myelodysplastic syndromes (MDS) and has an overall frequency of approximately 1%. The outcome of MDS patients with this translocation is not clear until now, because most of the clinical data addressing the t(2;11)(p21;q23) has been collected without investigating the status of the mixed lineage leukemia (MLL) gene. In this report, we present seven new patients with MDS diagnosis and the t(2;11)(p21;q23) in bone marrow cells; all of them without MLL gene rearrangement. They were found in two databases consisting of 1185 patients of two Czech institutions. These patients tended to be younger and showed a strong male predominance. A cytological and histological assessment of bone marrow at diagnosis revealed only mild MDS with marked dysplasia in megakaryopoiesis. Similar to other primary abnormalities in MDS (e.g. deletion of 11q), the t(2;11)(p21;q23) was frequently associated with deletion of 5q. Our results stress the common clinicopathological features of this entity and indicate that the t(2;11)(p21;q23) may be associated with a good prognosis for MDS patients (median survival 72 months).

  11. South-East Asia bovine populations and the Japanese cattle breeds do not harbour the E211K variant of the PRNP

    Directory of Open Access Journals (Sweden)

    George Msalya

    2014-02-01

    Full Text Available An important outcome of intensive worldwide Bovine spongiform encephalopathy (BSE obtained with the surveillance by The National Creutzfeldt-Jakob Disease Surveillance Unit (http://www.cjd.ed.ac.uk/figures. htm, has been the detection of atypical BSE in cattle. The discovery of a prion protein gene (PRNP E211K variant in an atypical BSE case is particularly remarkable because it is analogous to the most common pathogenic mutation in humans (E200K, which causes hereditary Creutzfeldt-Jakob disease (CJD. Knowledge of the distribution and frequency of PRNP E211K variants in cattle populations is critical for understanding and managing atypical BSE. This study was carried out to investigate the prevalence of the E211K variant in the South-East Asia bovine populations and in the Japanese cattle breeds. It was discovered that E211K variant was monomorphic for a G allele and the GG genotype in the 745 animals analyzed in this study. Therefore, neither the Bos indicus nor the Bos taurus animals analyzed are presently known to harbor the 211K variant predicting that the number of carriers for this variant will also be vanishingly low.

  12. Computing K and D meson masses with N{sub f}=2+1+1 twisted mass lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Baron, Remi [CEA, Centre de Saclay, 91 - Gif-sur-Yvette (France). IRFU/Service de Physique Nucleaire; Blossier, Benoit; Boucaud, Philippe [Paris XI Univ., 91 - Orsay (FR). Lab. de Physique Theorique] (and others)

    2010-05-15

    We discuss the computation of the mass of the K and D mesons within the framework of N{sub f}=2+1+1 twisted mass lattice QCD from a technical point of view. These quantities are essential, already at the level of generating gauge configurations, being obvious candidates to tune the strange and charm quark masses to their physical values. In particular, we address the problems related to the twisted mass flavor and parity symmetry breaking, which arise when considering a non-degenerate (c,s) doublet. We propose and verify the consistency of three methods to extract the K and D meson masses in this framework. (orig.)

  13. Computing K and D meson masses with N_f = 2+1+1 twisted mass lattice QCD

    CERN Document Server

    Baron, Remi; Carbonell, Jaume; Drach, Vincent; Farchioni, Federico; Herdoiza, Gregorio; Jansen, Karl; Michael, Chris; Montvay, Istvan; Pallante, Elisabetta; Pene, Olivier; Reker, Siebren; Urbach, Carsten; Wagner, Marc; Wenger, Urs

    2010-01-01

    We discuss the computation of the mass of the K and D mesons within the framework of N_f = 2+1+1 twisted mass lattice QCD from a technical point of view. These quantities are essential, already at the level of generating gauge configurations, being obvious candidates to tune the strange and charm quark masses to their physical values. In particular, we address the problems related to the twisted mass flavor and parity symmetry breaking, which arise when considering a non-degenerate (c,s) doublet. We propose and verify the consistency of three methods to extract the K and D meson masses in this framework.

  14. Measurement of cytokeratin 19 fragments as a marker of lung cancer by CYFRA 21-1 enzyme immunoassay.

    OpenAIRE

    Takada, M; Masuda, N.; Matsuura, E.; Kusunoki, Y; Matui, K.; Nakagawa, K.; Yana, T.; Tuyuguchi, I.; Oohata, I.; Fukuoka, M

    1995-01-01

    Soluble cytokeratin fragment 19 levels were measured with an enzyme immunoassay method developed by Boehringer Mannheim (Enzymun-Test CYFRA 21-1) in the serum of 185 patients with lung cancer [149 with non-small-cell lung cancer (NSCLC) and 36 with small-cell lung cancer (SCLC)] and 97 patients with benign lung diseases in order to determine its clinical usefulness in the diagnosis of lung cancer and follow-up of treatment. We used the cut-off value of 3.5 ng ml-1, established by the Japan CY...

  15. 联合检测血清Cyfra 21-1、CK19-2G2在非小细胞肺癌患者中的诊断%Clinical diagnostic value of combined detection of serum Cyfra 21-1 and CK19-2G2 in patients with non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    廖长征; 徐文莉; 魏晟潇; 许瑞环; 刘紫菱; 罗艺

    2014-01-01

    目的::探讨联合检测血清Cyfra 21-1、CK19-2G2在非小细胞肺癌患者中的诊断。方法:采用化学发光免疫法检测92例非小细胞肺癌患者、83例肺部良性疾病患者和90例健康体检者血清Cyfra 21-1、CK19-2G2的浓度,并判断两者的相关性。比较单独与联合检测Cyfra21-1、CK19-2G2对于诊断非小细胞肺癌的灵敏度和特异性。结果:非小细胞肺癌组血清Cyfra 21-1、CK19-2G2水平显著高于肺部良性疾病组和健康对照组( P<0.01);非小细胞肺癌患者血清Cyfra 21-1与CK19-2G2水平呈正相关性( P<0.05)。两者联合诊断非小细胞肺癌的灵敏度为82.7%、特异性为78%。结论:Cyfra 21-1、CK19-2G2是有效的诊断非小细胞肺癌的肿瘤标志物。血清Cyfra 21-1、CK19-2G2水平在非小细胞肺癌的诊断中有临床应用价值,两者联合检测的灵敏度和特异性高。%Objective:To investigate the clinical diagnostic value of the combined detection of serum Cyfra 21-1 and CK19-2G2 in patients with the non-small cell lung cancer ( NSCLC ) . Methods:The levels of serum Cyfra 21-1 and CK19-2G2 in 92 cases of NSCLC,83 of benign lung diseases and 90 of healthy controls were detected by chemiluminescent immunoassay. And the correlation between Cyfra 21-1 and CK19-2G2 was evaluated.Moreover,the sensitivity and specificity of combined detection of serum Cyfra 21-1 and CK19-2G2 for of the diagnosis of the NSCLC was compared with detection of either alone.Results:The Cyfra 21-1 and CK19-2G2 levels in serum of the NSCLC patients were significantly higher than those with benign lung disease and healthy controls (P<0.01).The Cyfra 21-1 and CK19-2G2 levels of the NSCLC patients were positively correlated (P<0. 05).Combined detection of both biomarkers in NSCLC yielded a sensitivity of 82.7% and a specificity of 78%. Conclusions:Cyfra 21-1 and CK19-2G2 are effective tumor markers for the diagnosis of NSCLC. With high sensitivity and specificity of

  16. Clinical diagnostic value of combined detection of serum Cyfra 21-1 and CK19-2G2 in patients with non-small cell lung cancer%联合检测血清Cyfra 21-1、CK19-2G2在非小细胞肺癌患者中的诊断

    Institute of Scientific and Technical Information of China (English)

    廖长征; 徐文莉; 魏晟潇; 许瑞环; 刘紫菱; 罗艺

    2014-01-01

    Objective:To investigate the clinical diagnostic value of the combined detection of serum Cyfra 21-1 and CK19-2G2 in patients with the non-small cell lung cancer ( NSCLC ) . Methods:The levels of serum Cyfra 21-1 and CK19-2G2 in 92 cases of NSCLC,83 of benign lung diseases and 90 of healthy controls were detected by chemiluminescent immunoassay. And the correlation between Cyfra 21-1 and CK19-2G2 was evaluated.Moreover,the sensitivity and specificity of combined detection of serum Cyfra 21-1 and CK19-2G2 for of the diagnosis of the NSCLC was compared with detection of either alone.Results:The Cyfra 21-1 and CK19-2G2 levels in serum of the NSCLC patients were significantly higher than those with benign lung disease and healthy controls (P<0.01).The Cyfra 21-1 and CK19-2G2 levels of the NSCLC patients were positively correlated (P<0. 05).Combined detection of both biomarkers in NSCLC yielded a sensitivity of 82.7% and a specificity of 78%. Conclusions:Cyfra 21-1 and CK19-2G2 are effective tumor markers for the diagnosis of NSCLC. With high sensitivity and specificity of the combined detection,serum Cyfra 21-1 and CK19-2G2 levels are clinically useful in the diagnosis of NSCLC.%目的::探讨联合检测血清Cyfra 21-1、CK19-2G2在非小细胞肺癌患者中的诊断。方法:采用化学发光免疫法检测92例非小细胞肺癌患者、83例肺部良性疾病患者和90例健康体检者血清Cyfra 21-1、CK19-2G2的浓度,并判断两者的相关性。比较单独与联合检测Cyfra21-1、CK19-2G2对于诊断非小细胞肺癌的灵敏度和特异性。结果:非小细胞肺癌组血清Cyfra 21-1、CK19-2G2水平显著高于肺部良性疾病组和健康对照组( P<0.01);非小细胞肺癌患者血清Cyfra 21-1与CK19-2G2水平呈正相关性( P<0.05)。两者联合诊断非小细胞肺癌的灵敏度为82.7%、特异性为78%。结论:Cyfra 21-1、CK19-2G2是有效的诊断非小细胞肺癌的肿瘤标志物。血清Cyfra 21-1、CK19-2G2

  17. Clinical significance of combined determination of several tumor markers (including CYFRA21-1, NSE, CA-50 and CEA) in patients with pulmonary cancer

    International Nuclear Information System (INIS)

    Objective: To enhance the diagnosis of pulmonary cancer by determination of optimal combinations of various tumor markers. Methods: Serum CYFRA21-1, NSE, CA-50 (with RIA) and CEA (with CLIA) contents were determined in 107 patients with various types of pulmonary cancers, 66 patients with various benign pulmonary diseases and 59 controls. Results: It was revealed that CYFRA21-1 determination was most sensitive for detection of squamous cell carcinoma. The same was true for CEA in the detection of adenocarcinoma. NSE determination was very specific for small cell carcinoma. Combined determinations of either CYFRA21-l + NSE or CYFRA21-1 + NSE + CEA were excellent for general screening. Conclusion: Combined determination of these tumor markers could be applied expediently as supplementary diagnostic measure for pulmonary malignancies. (authors)

  18. Surface roughness estimation of MBE grown CdTe/GaAs(211)B by ex-situ spectroscopic ellipsometry

    Science.gov (United States)

    Karakaya, Merve; Bilgilisoy, Elif; Arı, Ozan; Selamet, Yusuf

    2016-07-01

    Spectroscopic ellipsometry (SE) ranging from 1.24 eV to 5.05 eV is used to obtain the film thickness and optical properties of high index (211) CdTe films. A three-layer optical model (oxide/CdTe/GaAs) was chosen for the ex-situ ellipsometric data analysis. Surface roughness cannot be determined by the optical model if oxide is included. We show that roughness can be accurately estimated, without any optical model, by utilizing the correlation between SE data (namely the imaginary part of the dielectric function, or phase angle, ψ) and atomic force microscopy (AFM) roughness. and ψ values at 3.31 eV, which corresponds to E1 critical transition energy of CdTe band structure, are chosen for the correlation since E1 gives higher resolution than the other critical transition energies. On the other hand, due to the anisotropic characteristic of (211) oriented CdTe surfaces, SE data ( and ψ) shows varieties for different azimuthal angle measurements. For this reason, in order to estimate the surface roughness by considering these correlations, it is shown that SE measurements need to be taken at the same surface azimuthal angle. Estimating surface roughness in this manner is an accurate way to eliminate cumbersome surface roughness measurement by AFM.

  19. De novo interstitial direct duplication of Xq21.1q25 associated with skewed X-inactivation pattern.

    Science.gov (United States)

    Tachdjian, G; Aboura, A; Benkhalifa, M; Creveaux, I; Foix-Hélias, L; Gadisseux, J F; Boespflug-Tanguy, O; Mohammed, M; Labrune, P

    2004-12-15

    Genotype-phenotype correlation in women with an abnormal phenotype associated with a duplication of the long arm of the X chromosome remains unclear. We report on prenatal diagnosis and follow-up of a girl with an Xq duplication and dysmorphic features. The abnormal phenotype included growth retardation, hypotonia, and nystagmus. In order to improve the resolution of the cytogenetic analysis, we used both conventional and array-based comparative genomic hybridization to perform a global molecular cytogenetic analysis of the genome. These molecular cytogenetic analyses showed a direct duplication Xq21.1 --> q25 without other chromosomal abnormalities. This duplication was originating from the paternal X chromosome. Moreover, a skewed X-inactivation pattern was observed leading to a partial functional disomy of the chromosomal region Xq21.1q25. This report and review of the literature suggest that functional disomy for chromosome X could explain the abnormal phenotype. In prenatal diagnosis, this can have implication for patient management and genetic counseling.

  20. Gamma-ray flaring activity from the gravitationally lensed blazar PKS 1830-211 observed by Fermi LAT

    CERN Document Server

    Abdo, A A; Ajello, M; Allafort, A; Amin, M A; Baldini, L; Barbiellini, G; Bastieri, D; Bechtol, K; Bellazzini, R; Blandford, R D; Bonamente, E; Borgland, A W; Bregeon, J; Brigida, M; Buehler, R; Bulmash, D; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Cavazzuti, E; Cecchi, C; Charles, E; Cheung, C C; Chiang, J; Chiaro, G; Ciprini, S; Claus, R; Cohen-Tanugi, J; Conrad, J; Corbet, R H D; Cutini, S; D'Ammando, F; de Angelis, A; de Palma, F; Dermer, C D; Drell, P S; Drlica-Wagner, A; Favuzzi, C; Finke, J; Focke, W B; Fukazawa, Y; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Giglietto, N; Giordano, F; Giroletti, M; Glanzman, T; Grenier, I A; Grove, J E; Guiriec, S; Hadasch, D; Hayashida, M; Hays, E; Hughes, R E; Inoue, Y; Jackson, M S; Jogler, T; Jòhannesson, G; Johnson, A S; Kamae, T; Knödlseder, J; Kuss, M; Lande, J; Larsson, S; Latronico, L; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Mazziotta, M N; Mehault, J; Michelson, P F; Mizuno, T; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nemmen, R; Nuss, E; Ohno, M; Ohsugi, T; Paneque, D; Perkins, J S; Pesce-Rollins, M; Piron, F; Pivato, G; Porter, T A; Rainò, S; Rando, R; Razzano, M; Reimer, A; Reimer, O; Reyes, L C; Ritz, S; Romoli, C; Roth, M; Parkinson, P M Saz; Sgrò, C; Siskind, E J; Spandre, G; Spinelli, P; Takahashi, H; Takeuchi, Y; Tanaka, T; Thayer, J G; Thayer, J B; Thompson, D J; Tibaldo, L; Tinivella, M; Torres, D F; Tosti, G; Troja, E; Tronconi, V; Usher, T L; Vandenbroucke, J; Vasileiou, V; Vianello, G; Vitale, V; Waite, A P; Werner, M; Winer, B L; Wood, K S

    2014-01-01

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the highly dust-absorbed, reddened, and MeV-peaked flat spectrum radio quasar PKS 1830-211 (z=2.507). Its apparent isotropic gamma-ray luminosity (E>100 MeV) averaged over $\\sim$ 3 years of observations and peaking on 2010 October 14/15 at 2.9 X 10^{50} erg s^{-1}, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time delayed variability to follow about 25 days after a primary flare, with flux about a factor 1.5 less. Two large gamma-ray flares of PKS 1830-211 have been detected by the LAT in the considered period and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the gamma rays flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program ...

  1. A Multi-Epoch SMA Study of the HH 211 Protostellar Jet: Jet Motion and Knot Formation

    CERN Document Server

    Jhan, Kai-Syun

    2015-01-01

    HH 211 is a highly collimated jet with a chain of well-defined knots, powered by a nearby young Class 0 protostar. We have used 4 epochs (2004, 2008, 2010, and 2013) of Submillimeter Array (SMA) archive data to study the properties of the HH 211 jet in SiO (J=8-7). The jet shows similar reflection-symmetric wiggle structures in all epochs. The wiggle structures can all be fitted by an orbiting jet source model that includes a position shift due to proper motion of the jet, indicating that the wiggle propagates along the jet axis. Thus, this suggests the wiggle is indeed due to an orbital motion of the jet source. Proper motions of the knots are measured by using the peak positions of the knots in four epochs, and they are roughly the same and independent of the distance from the central source. The mean proper motion of the knots is $\\sim$ 0.087 arcsec per year, resulting in a transverse velocity of $\\sim$ 114 km s$^{-1}$, about 30\\% lower than that measured before. Knots BK2 and BK3 have a well-defined linea...

  2. Diagnostic value of CYFRA 21-1 and CEA for predicting lymph node metastasis in operable lung cancer.

    Science.gov (United States)

    Chen, Feng; Yan, Cui-E; Li, Jia; Han, Xiao-Hong; Wang, Hai; Qi, Jun

    2015-01-01

    Tumour markers are used extensively for the management of lung cancer, including diagnosis, evaluating effectiveness of treatments, monitoring recurrence after therapy and for predicting prognosis. However, there exists a knowledge gap regarding potential quantitative correlations between tumour marker levels and the extents of lymph node involvement in primary lung cancer. The current study is comprised of 139 lung cancer patients scheduled to undergo surgical operation. Of the 139 patients, 107 were subsequently diagnosed with lung cancer without lymph node involvement and 32 were diagnosed with malignant disease with lymph node involvement by histological examination. Preoperative tumour marker levels were quantified in each patient. The median tumour marker levels were statistically higher in lung cancer patients with malignant lymph nodes than in those who suffered either benign lung disease or carcinoma in situ (Kruskal-Wallistest; P = 0.001). Tumour marker levels were significantly correlated with clinical stage (ANOVA; P = 0.009). When examined as a dichotomous variable (CYFRA 21-1 ≤ 5.0 and CEA ≤ 5.0 group and CYFRA 21-1 > 5.0 or CEA > 5.0 group), elevated tumour marker levels correlated strongly with the presence of positive lymph nodes (χ(2) test; P = 0.000). This correlation suggests that the tumour marker levels are clinical predictors for the malignant involvement of lymph nodes in operable lung cancer patients. PMID:26309663

  3. An ab initio study of niobium(n=2-11)clusters:structure,stability and magnetism

    Institute of Scientific and Technical Information of China (English)

    Ren Feng-Zhu; Wang Yuan-Xu; Zhang Guang-Biao; Wei Shu-Ke; Luo You-Hua

    2009-01-01

    The ground-state configurations of the Nbn(n2-11)clusters are studied through the first-principles calculations.It is found that niobium clusters(n=2-11)tend to form compact structures with low symmetry.The clusters with 4,8 and 10 atoms axe found to be magic and have relatively large highest occupied-lowest unoccupied molecular orbital(HOMO-LUMO)gaps.The Nbn clusters possess low magnetic moments,which exhibit an odd-even oscillational character.The analyses of calculated electronic density and population of the lowest-energy niobium clusters for n=2,3,5,7,9,11 show that the total magnetic moments of Nbn originate mainly from a few Nb atoms with longer spacings between them in most cases,while thcy are located on two Nb atoms for n=2,3,5.The total magnetic moments come mainly from the 4d local moments but with the exception of the Nb5 cluster.

  4. Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after Administration.

    Directory of Open Access Journals (Sweden)

    Nils Rudqvist

    Full Text Available 211At-labeled radiopharmaceuticals are potentially useful for tumor therapy. However, a limitation has been the preferential accumulation of released 211At in the thyroid gland, which is a critical organ for such therapy. The aim of this study was to determine the effect of absorbed dose, dose-rate, and time after 211At exposure on genome-wide transcriptional expression in mouse thyroid gland.BALB/c mice were i.v. injected with 1.7, 7.5 or 100 kBq 211At. Animals injected with 1.7 kBq were killed after 1, 6, or 168 h with mean thyroid absorbed doses of 0.023, 0.32, and 1.8 Gy, respectively. Animals injected with 7.5 and 100 kBq were killed after 6 and 1 h, respectively; mean thyroid absorbed dose was 1.4 Gy. Total RNA was extracted from pooled thyroids and the Illumina RNA microarray platform was used to determine mRNA levels. Differentially expressed transcripts and enriched GO terms were determined with adjusted p-value 1.5, and p-value <0.05, respectively.In total, 1232 differentially expressed transcripts were detected after 211At administration, demonstrating a profound effect on gene regulation. The number of regulated transcripts increased with higher initial dose-rate/absorbed dose at 1 or 6 h. However, the number of regulated transcripts decreased with mean absorbed dose/time after 1.7 kBq 211At administration. Furthermore, similar regulation profiles were seen for groups administered 1.7 kBq. Interestingly, few previously proposed radiation responsive genes were detected in the present study. Regulation of immunological processes were prevalent at 1, 6, and 168 h after 1.7 kBq administration (0.023, 0.32, 1.8 Gy.

  5. Disease monitoring by the tumour maskers Cyfra 21.1 and TPA in patients with non-small cell lung cancer

    OpenAIRE

    van der Gaast, Ate; Kok, Tjebbe; Kho, Marcia; Blijenberg, Bert; Splinter, Ted

    1995-01-01

    textabstractWe evaluated the use of two tumour markers Cyfra 21.1 and tissue polypeptide antigen (TPA) for disease monitoring. Assessment of response to WHO criteria was compared to response assessment according to changes in the tumour marker levels. The criteria defined for marker response were a 65% decrease for a partial response and a 40% increase for progressive disease. When response evaluations with a positive lead time were included, 72% of 115 evaluations for Cyfra 21.1 and 59% of 1...

  6. Fine-Needle Aspirates CYFRA 21-1 is a Useful Tumor Marker for Detecting Axillary Lymph Node Metastasis in Breast Cancer Patients

    OpenAIRE

    Jung Hyun Yoon; Kyung Hwa Han; Eun-Kyung Kim; Hee Jung Moon; Min Jung Kim; Young Joo Suh; Ji Soo Choi; Byeong-Woo Park

    2013-01-01

    INTRODUCTION: To assess whether the value of CYFRA21-1 in the aspirates of ultrasonography-guided fine-needle aspiration biopsy (US-FNAB) can contribute to improving the performances of US-FNAB in the diagnosis of axillary lymph node (LN) metastasis in breast cancer patients. METHODS: US-FNAB was performed in 156 axillary LNs in 152 breast cancer patients (mean age: 51.4 years, range: 17-92 years). Concentrations of CYFRA21-1 were measured from washouts of the syringe used during US-FNAB. Tum...

  7. Preoperative CYFRA 21-1 and CEA as Prognostic Factors in Patients with Stage I Non-Small Cell Lung Cancer

    OpenAIRE

    Blankenburg, Florian; Hatz, Rudolf; Nagel, Dorothea; Ankerst, Donna Pauler; Reinmiedl, Judith; Gruber, Christine; Seidel, Dietrich; Stieber, Petra

    2008-01-01

    Objective: To validate the prognostic value of preoperative levels of CYFRA 21-1, CEA and the corresponding tumor marker index (TMI) in patients with stage I non-small cell lung cancer (NSCLC). Methods: Two hundred forty stage I NSCLC patients (80 in pT1 and 160 in pT2; 100 squamous cell carcinomas, 91 adenocarcinomas, 32 large-cell carcinomas, 17 with other histologies; 171 males and 69 females) who had complete resection (R0) between 1986 and 2004 were included in the analysis. CYFRA 21-1 a...

  8. The prognostic value of the tumour marker Cyfra 21-1 in carcinoma of head and neck and its role in early detection of recurrent disease

    OpenAIRE

    Doweck, I.; Barak, M; Uri, N; Greenberg, E

    2000-01-01

    This study examines a new tumour marker, Cyfra 21-1, as a prognostic marker in predicting the survival of H&N cancer patients, and its correlation with clinical outcome during prolonged follow up of these patients. The study included 67 patients with primary detection of carcinoma of H&N. The survival of these patients was evaluated in correlation with the disease stage and Cyfra 21-1 levels at initial diagnosis. 38 patients were followed clinically and with serial assays for at least 12 mont...

  9. Fine-needle aspirates CYFRA 21-1 is a useful tumor marker for detecting axillary lymph node metastasis in breast cancer patients.

    Directory of Open Access Journals (Sweden)

    Jung Hyun Yoon

    Full Text Available INTRODUCTION: To assess whether the value of CYFRA21-1 in the aspirates of ultrasonography-guided fine-needle aspiration biopsy (US-FNAB can contribute to improving the performances of US-FNAB in the diagnosis of axillary lymph node (LN metastasis in breast cancer patients. METHODS: US-FNAB was performed in 156 axillary LNs in 152 breast cancer patients (mean age: 51.4 years, range: 17-92 years. Concentrations of CYFRA21-1 were measured from washouts of the syringe used during US-FNAB. Tumor marker concentrations, US-FNAB, intraoperative sentinel node biopsy (SNB, and surgical pathology results were reviewed and analyzed. For comparison, the values of CEA and CA15-3 were also measured from washouts. RESULTS: Among the 156 LNs, 75 (48.1% were benign, and 81 (51.9% were metastases. Mean concentrations of CYFRA21-1 were significantly higher in metastasis compared to benign LNs (P<0.001. US-FNAB combined to CYFRA21-1 showed significantly higher sensitivity, NPV, and accuracy compared to US-FNAB alone (all values P<0.05. All diagnostic indices of US-FNAB combined to CYFRA21-1 were significantly higher compared to US-FNAB combined with CEA or CA15-3 (all P<0.001. Of the 28 metastatic LNs which showed metastasis on SNB, CYFRA21-1 showed higher positive rate of 75.0% (CEA or CA15-3∶60.7%, P = 0.076. CONCLUSION: Measuring CYFRA 21-1 concentrations from US-FNAB aspirates improves sensitivity, NPV, and accuracy of US-FNAB alone, and may contribute to reducing up to 75.0% of unnecessary intraoperative SNB. Compared to CEA or CA15-3, CYFRA21-1 shows significantly higher performances when combined to US-FNAB in the preoperative diagnosis of LN metastasis in breast cancer patients.

  10. 血清p53抗体联合CEA、CYFRA21-1检测在肺癌诊断中的价值%Role of combined detection of serum anti-p53 antibody with CEA and CYFRA21-1 in the diagnosis of lung cancer

    Institute of Scientific and Technical Information of China (English)

    杜紫燕; 余勇; 张增利; 李凌云; 邢玉斐; 施敏骅

    2013-01-01

    目的 探讨联合检测肺癌患者血清p53抗体与癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)辅助肺癌诊断的可行性.方法 在57例肺癌(肺癌组)和40例肺部良性疾病患者(对照组),采用ELISA法检测血清p53抗体,采用电化学发光免疫分析法检测血清CEA和CYFRA21-1.结果 肺癌组血清p53抗体、CEA和CYFRA21-1水平均高于对照组(P<0.05).p53抗体、CEA、CYFRA21-1曲线下面积(AUC)分别为0.770、0.814、0.779.p53抗体、CEA和CYFRA21-1的诊断界点分别为1.150 U/ml、3.095 ng/ml、3.240 ng/ml,敏感性分别为45.61%、66.67%、68.42%,特异性分别为87.50%、87.50%、85.00%.三项联合检测的AUC为0.902,敏感性为89.47%,特异性为100%.CEA与CYFAR21-1呈正相关(r=0.555,P<0.05).结论 血清p53抗体为独立的肺癌生物标记物,与CEA、CYFRA21-1联合检测有助于提高肺癌诊断水平.%Objective To explore the value of combined detection of serum anti-p53 antibody with carcinoembryonic antigen(CEA) and CYFRA21-1 in the diagnosis of lung cancer. Methods In 57 patients with lung cancer (group A) and 40 patients with benign pulmonary diseases (group B), serum levels of anti-p53 antibody, CEA and CYFRA 21-1 were measured by ELISA and electro-chemiluminescence immunoassay. Results Serum levels of anti-p53 antibody, CEA and CYFRA21-1 were higher in group A than those in group B(P<0. 05). The values of receiver operating characteristic area under the curve(AUC) for anti-p53 antibody,CEA and CYFRA 21-1 were 0. 770, 0. 814 and 0. 779, respectively. The cutoff levels of anti-p53 antibody, CEA and CYFRA 21-1 were 1. 150 U/ml,3. 095 ng/ml and 3. 240 ng/ml, respectively. The sensitivities of those markers for lung cancer detection were 45. 61%,66. 67%, 68. 42%, while the specificities were 87. 50%, 87. 50% and 85. 00% respectively. The value of AUC, sensitivity and specificity were 0. 90, 89. 47% and 100%, respectively,when combined detection of the three markers was

  11. Prognostic value on detection of Cyfra 21-1 concentration in serum from primary oral squamous cell carcinoma patients%口腔鳞癌首诊患者血清Cyfra 21-1检测的预后评价价值

    Institute of Scientific and Technical Information of China (English)

    钟来平; 郑家伟; 张志愿; 张陈平; 陈万涛; 竺涵光

    2007-01-01

    目的:探讨在口腔鳞癌首诊患者中检测血清Cyfra 21-1含量的预后价值.方法:收集56例正常人和107例口腔鳞癌首诊患者的治疗前血清样本,采用ELISA方法检测血清中Cyfra 21-1的含量,跟踪随访12~57个月,采用SPSS10.0统计软件包进行相关分析.结果:口腔鳞癌首诊患者治疗前血清Cyfra 21-1含量为(1.14±1.19)μg/L,显著高于对照组的(0.40±0.16)μg/L(P=0.001);其检测敏感度和特异度分别为55.1%和96.4%.结合跟踪随访,肿瘤复发和死亡的患者,治疗前血清Cyfra 21-1含量显著高于肿瘤不复发(P=0.026)和存活(P=0.001)的患者,血清Cyfra 21-1含量越高,患者生存率越低,生存时间越短(P=0.003).结论:口腔鳞癌患者血清Cyfra 21-1含量显著升高,并且与预后相关.检测血清Cyfra 21-1含量对口腔鳞癌患者具有一定的临床应用价值.

  12. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  13. Construction of University Collections among Universities of "211 Project" and Guangdong Province%“211”及广东省高校文库建设调查与分析

    Institute of Scientific and Technical Information of China (English)

    罗莹

    2012-01-01

    统计“211”高校以及广东省高校文库(含机构知识库)的建设情况,分析特色个案,认为本校原创智力产品的收集和开发利用尚未成为高校图书馆普遍、常规的工作。提出要建立既有国际通用功能又有中国文化传承特色的机构知识库群落(或者联盟平台),而现有的数字文库可以成为机构知识库建设的资源基础。基于免费、共享理念的机构知识库有利于打破国内学术资源被部分数据商垄断的困境,值得从国家到高校自上而下的高度重视和行政推动。%After statistical analysis on the current construction situation of university collections (with institutional repositories) among "211 Project" universities and those in Guangdong Province with some typical cases, the author believes that the collections and applications of the original intellectual productions in universities haven' t been the routines of university libraries, and proposes to build up internationally functional and Chinese cultural institutional repository communities (or a platform for university unions), and the built digital university collections could be resources of institutional repositories. The institutional repositories with "free and share" ideas are in favor of breaking the predicament that the domestic academic resources are monopolized by part of the data vendors, and deserve high attentions and administrative promotions from nation to universities.

  14. Clinical value of CEA and CYFRA21-1 for the differentiation of benign and malignant pleural effusion by Meta analysis%CEA和CYFRA 21-1测定鉴别胸腔积液良恶性的Meta分析

    Institute of Scientific and Technical Information of China (English)

    顾平; 陈虞梅; 黄钢; 朱翠英; 袁济民

    2008-01-01

    目的 用Meta分析方法系统评价近10年来癌胚抗原(CEA)和细胞角蛋白19片段抗原21-1(CYFRA 21-1)在鉴别良恶性胸腔积液中的价值,并进一步比较两者在诊断效能上的差异.方法 收集1996年1月-2007年1月间国内外公开发表的关于CEA和CYFRA 21-1鉴别良恶性胸腔积液的文献,对纳入文献进行方法学质量评估后,运用Q检验评价数据的异质性,合并其灵敏度和特异性,用两者综合受试者工作特征(SROC)曲线下面积(AUC)评价和比较(Z检验)CEA和CYFRA 21-1鉴别良恶性胸腔积液的效能.结果 共有19篇文献纳入,研究对象3228例.CEA汇总的灵敏度和特异性[95%可信区间(CI)]为45.9%(43.2%~48.5%)和97.0%(96.0%~97.8%), CYFRA 21-1汇总的灵敏度和特异性(95%CI)为47.3%(44.0%~50.6%)和91.8%(89.5%~93.7%),其结果均存在明显的异质性(P<0.05).CEA和CYFRA 21-1的AUC分别为0.7691和0.8213,Z检验比较两者AUC差异无统计学意义(Z=0.45,P>0.05).结论 CEA和CYFRA 21-1在诊断良恶性胸腔积液时均具有较好的准确性.%Objective Pleural effusion is a common clinical complication caused by many benign or malignant diseases. Many published papers presented that tumor-marker assays, such as carcinoembryonic antigen (CEA) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), played a vital role on the benign and malignant differentiation. This study aimed to reviewe currently available published papers to evaluate the clinical value of those two markers for the differentiation of benign and malignant pleural effusion. Methods All published data of pleural effusion CEA and CYFRA21-1 for the differentiation studies from year 1996 to 2007 were reviewed. By methodological qualities and Q test, 19 papers were selected into this study. The overall diagnostic sensitivity, specificity, and area under curve (AUC) from receiver operating characteristic (ROC) curve were adopted to compare the value of pleural effusion CEA and CYFRA21-1 for

  15. Relation between Prognosis and CYFRA21-1 Level in the Peripheral Blood of Patients with Advanced Lung Cancer%外周血CYFRA21-1水平与晚期肺癌预后的关系分析

    Institute of Scientific and Technical Information of China (English)

    张旭峰; 郭志强; 王征

    2015-01-01

    目的 探讨晚期肺癌患者治疗前后外周血CYFRA21-1水平与其预后的关系. 方法 选择晚期肺癌患者148例,采用电化学发光免疫法对所得样本的血清CYFR21-1水平进行检测,将CYFRA21-1水平升高患者纳入高水平组81例,未升高患者纳入低水平组67例. 结果 化疗前与化疗2个周期时,高水平组患者CYFR21-1水平均显著高于低水平组患者,而经过化疗,高水平组患者的CYFR21-1水平明显下降,差异具有统计学意义(P<0.05);并且经过化疗后,低水平组患者的近期治疗有效率以及1年生存率和生存质量评分均显著高于高水平组患者,差异均具有统计学意义(P<0.05). 结论 血清CYFRA21-1的水平可以作为评价晚期非小细胞肺癌患者化疗的疗效指标,也能够对患者的生存期及预后进行评价.%Objective To investigate the relationship between peripheral blood CYFRA21-1 level and prognosis in pa-tients with advanced lung cancer.Methods Serum CYFR21-1 level in 148 advanced lung cancer patients was detected by elec-trochemiluminescence immunoassay,81 cases with elevated CYFRA21-1 was the high level group,67 cases without increase of CYFRA21-1 was the low level group.Results Before chemotherapy and 2 cycles after chemotherapy,CYFR21-1 level of the high level group was significantly higher than that of the low level group,and after chemotherapy,CYFR21-1 level of the high level group decreased significantly,the difference was statistically significant (P<0.05);and after chemotherapy,recent treatment effi-ciency,1-year survival rate and quality of life scores of the low level group were significantly higher than that of the high level group,the differences were statistically significant (P<0.05).Conclusion Serum CYFRA21-1 level could be used as indica-tors of efficacy evaluation of chemotherapy in patients with advanced non-small cell lung cancer,it can also evaluate the survival and prognosis of the patients.

  16. [Phenotypic variability of the 1q21.1 microdeletion syndrome in members of the same family: relevance of detection of neuropsychiatric disorders for diagnosis of genetic syndromes].

    Science.gov (United States)

    Natera-De Benito, Daniel; Vidal-Esteban, Arantxa; Sanchez-Del Pozo, Jaime; Moreno-Garcia, Marta; Suela-Rubio, Javier; Cruz-Rojo, Jaime; Rivero-Martin, María José

    2015-12-16

    Introduccion. El sindrome de microdelecion 1q21.1 esta causado por una delecion recurrente de aproximadamente 800 kb que incluye al menos siete genes y se asocia a un fenotipo variable. Esta variacion en el numero de copias patogenica puede aparecer de novo o ser heredada de uno de los progenitores. La presencia de trastornos psiquiatricos se ha descrito en muchos de los casos publicados, pero se desconoce su prevalencia exacta. Objetivo. Exponer la variabilidad fenotipica de los individuos que presentan una microdelecion 1q21.1. Casos clinicos. Se incluyen cuatro individuos portadores de una delecion de 1,74 Mb en 1q21.1, todos miembros de la misma familia. El estudio genetico del caso indice se llevo a cabo mediante array de hibridacion genomica comparada, y el del resto de familiares mediante hibridacion in situ fluorescente, con una sonda especifica para la region delecionada. Los individuos presentan un fenotipo heterogeneo, y es comun a todos ellos la presencia de alteraciones psiquiatricas o del comportamiento, con un claro predominio de la presencia de trastornos relacionados con las dificultades para el control de impulsos en sus diferentes subtipos. Conclusiones. El sindrome de microdelecion 1q21.1 es fenotipicamente heterogeneo, incluso entre los miembros de una misma familia. Destaca la presencia de alteraciones psiquiatricas o del comportamiento como rasgo comun en todos los pacientes que presentamos. Existen formas paucisintomaticas en las que el individuo portador de la delecion presenta exclusivamente alteraciones psiquiatricas.

  17. miR-211 is a pro-survival micro-RNA that regulates chop expression in a PERK-dependent manner

    Science.gov (United States)

    Chitnis, Nilesh; Pytel, Dariusz; Bobrovnikova-Marjon, Ekaterina; Pant, Dhruv; Zheng, Hui; Maas, Nancy; Frederick, Brian; Kushner, Jake A.; Chodosh, Lewis A.; Koumenis, Constantinos; Fuchs, Serge Y.; Diehl, J. Alan

    2012-01-01

    Micro-RNAs typically function at the level of post-transcriptional gene silencing within the cytoplasm; however increasing evidence suggests that they may also function in nuclear, Argonaut containing complexes, to directly repress target gene transcription. We have investigated the role of micro-RNAs in mediating endoplasmic reticulum (ER) stress responses. ER stress triggers the activation of three signaling molecules: Ire-1α/β, PERK and ATF6 whose function is to facilitate adaption to the ensuing stress. We demonstrate that PERK induces miR-211, which in turn attenuates stress-dependent expression of the pro-apoptotic transcription factor chop/gadd153. MiR-211 directly targets the proximal chop/gadd153 promoter where it increases histone methylation and represses chop expression. Maximal chop accumulation ultimately correlates with miR-211 down regulation. Our data suggests a model where PERK-dependent miR-211 induction prevents premature chop accumulation and thereby provides a window of opportunity for the cell to re-establish homeostasis prior to apoptotic commitment. PMID:23022383

  18. Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Elgström, Erika; Bäck, Tom;

    2014-01-01

    for small, established tumors. A combination of such radionuclides may be successful in regimens of radioimmunotherapy. In this study, rats were treated by sequential administration of first a 177Lu-labeled antibody, followed by a 211At-labeled antibody 25 days later. METHODS: Rats bearing solid colon...

  19. Thrombocytopenia-absent radius (TAR) syndrome: a clinical genetic series of 14 further cases. impact of the associated 1q21.1 deletion on the genetic counselling.

    Science.gov (United States)

    Houeijeh, Ali; Andrieux, Joris; Saugier-Veber, Pascale; David, Albert; Goldenberg, Alice; Bonneau, Dominique; Fouassier, Marc; Journel, Hubert; Martinovic, Jelana; Escande, Fabienne; Devisme, Louise; Bisiaux, Sophie; Chaffiotte, Caroline; Baux, Mathilde; Kerckaert, Jean-Pierre; Holder-Espinasse, Muriel; Manouvrier-Hanu, Sylvie

    2011-01-01

    Thrombocytopenia-absent radius Syndrome (TAR) is a rare congenital malformation syndrome of complicated transmission. 1q21.1 deletion is necessary but not sufficient for its expression. We report the result of a French multicentric clinical study, and we emphasized on the role of the associated 1q21.1 deletion in the diagnosis and the genetic counselling of our patients. We gathered information on 14 patients presenting with TAR syndrome and referred for genetic counselling in six different university hospitals (8 foetuses, 1 child and 5 adults). Clinical or pathology details, as well as skeletal X-rays were analyzed. Genetic studies were performed by Array-CGH, and Quantitative Multiplex PCR. We demonstrated the very variable phenotypes of TAR syndrome. Female:male ratio was ∼2:1. All patients presented with bilateral radial aplasia/hypoplasia with preserved thumbs. Phocomelia and lower limb anomalies were present in 28% of the cases. We reported the first case of cystic hygroma on affected foetus. 1q21.1 deletions ranging from 330 to 1100 kb were identified in all affected patients. Most of them were inherited from one healthy parent (80%). The identification of a 1q21.1 deletion allowed confirmation of TAR syndrome diagnosis, particularly in foetuses and in atypical phenotypes. Additionally, it allowed accurate genetic counselling, especially when it occurred de novo. These findings allowed discussing the diagnostic criteria and management towards TAR syndrome.

  20. 76 FR 20229 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-Trent 768-60 and Trent 772-60 Turbofan Engines

    Science.gov (United States)

    2011-04-12

    ... (63 FR 49416, September 16, 1998). We must receive any comments on this AD by May 27, 2011. ADDRESSES... 39-10754 (63 FR 49416, September 16, 1998), for RR RB211-Trent 700 series turbofan engines. That AD... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in...

  1. CYFRA21-1、NSE、CA125、CEA联合检测在肺癌诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    梁华刚; 傅昭然

    2010-01-01

    目的 评价外周血细胞角蛋白19片段(CYFRA 21-1)、神经特异性烯醇化酶(NSE)、糖类抗原(CA125)和癌胚抗原(CEA)联合检测对肺癌的临床诊断价值.方法 采用化学免疫发光法测定100例肺癌(肺癌组)、50例良性肺部疾病(良性组)患者和50例健康人(对照组)外周血中的CYFRA21-1、NSE、CA125、CEA.结果 肺癌组CYFRA21-1、NSE、CA125、CEA阳性率分别为57% 、28%、54%、58%,良性组分别为8%、10%、12%、18%,对照组分别为6%、8%、6%、8%.4项联合检测灵敏性、特异性和准确性分别为72.0%、90.0%、78.0%.结论 血清CYFRA21-1、NSE、CA125、CEA联合检测有利于肺癌的临床诊断.

  2. Predictive and prognostic value of serum CEA and CYFRA21-1 in patients with advanced non-small cell lung cancer%非小细胞肺癌患者血清CEA和CYFRA21-1检测预测疗效及预后价值的探讨

    Institute of Scientific and Technical Information of China (English)

    胡晓晔; 吴海鹰; 黄河; 戴文清; 彭晋; 万小云

    2008-01-01

    目的:评价晚期非小细胞肺癌(NSCLC)化疗后血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)水平的下降在预测疗效及预后中的价值.方法:82例接受一线化疗的晚期NSCLC患者,于化疗前及第2个周期后分别以电化学发光免疫测定法检测血清CEA、CYFRA21-1的水平,同时行影像学检查评价客观疗效以及进行生存随访.通过建立ROC曲线,评估CEA、CYFRA21-1下降率在评价化疗疗效上的价值.结果:第2个周期后影像学方法评价的客观有效率为35%(29/82).以CEA、CYFRA21-1下降率评价的有效率分别为57%(47/82)、48%(39/82).影像学方法评价的客观有效率与CEA、CYFRA21-1评价的有效率差异有统计学意义,P=0.03.中位生存时间11个月.单因素分析显示体能评分(PS评分)、基线乳酸脱氢酶(LDH)水平及CYFRA21-1下降率与生存有显著相关性.经多因素分析显示,基线LDH(P=0.009)、CYFRA21-1下降率(P=0.02)是影响晚期NSCLC生存的独立预后因素.结论:晚期NSCLC化疗后血清CEA及CYFRA 21-1下降率是反映化疗疗效的可靠指标.血清CYFRA 21-1在化疗期间下降明显者提示预后较好.

  3. The diagnostic and prognostic significance on detection of Cyfra 21-1 in head and neck squamous cell carcinoma patients%Cyfra 21-1肿瘤标志物在头颈鳞癌诊断和预后评价中的作用

    Institute of Scientific and Technical Information of China (English)

    钟来平; 刘炜; 赵士芳; 陈关福

    2004-01-01

    Cyfra 21-1是近年来发现的一种细胞角蛋白19的可溶性片段,随着细胞发生癌变,癌细胞可以释放Cyfra21-1进入循环系统而被检测出来,因此越来越被广大临床医师所重视,包括头颈部外科医师也越来越重视Cyfra21-1在头颈部鳞状细胞癌中的临床应用价值.目前Cyfra 21-1被认为可作为判断头颈鳞癌患者预后的肿瘤标志物之一,但对头颈鳞癌的早期诊断价值尚存在争议.本文就Cyfra 21-1的特点以及在头颈部鳞状细胞癌中的临床应用新进展进行综述.

  4. [A case of advanced gastric cancer showing high serum CYFRA21-1 level responding to chemotherapy with S-1].

    Science.gov (United States)

    Hara, Akihito; Watanabe, Hiroaki

    2008-12-01

    The patient was a 75-year-old man whose complaint was back pain and appetite loss. He was diagnosed with unresectable advanced gastric cancer due to multiple liver metastases and direct invasion of pancreas and spleen. He underwent gastrostomy because of esophageal stenosis, and we administered S-1 80 mg/body(4 weeks administration and 2 weeks rest)to the patient through a gastrostogavage tube. On blood examination, the serum level of CYFRA21- 1 was significantly high, while those of CEA and CA19-9 were within normal ranges. After the first course of this chemotherapy, the serum CYFRA21-1 level significantly decreased with reduction of the cancer. After the second course, it sensitively increased before image views detected the progression of the cancer. This case shows that CYFRA21- 1 could be a useful tumor marker of advanced gastric cancer.

  5. [Thymoma with extensive coagulative necrosis and high serum level of CYFRA 21-1; report of a case].

    Science.gov (United States)

    Himuro, Naoya; Minakata, Takao; Oshima, Yutaka; Tomita, Yuri; Kataoka, Daisuke; Kadokura, Mitsutaka

    2014-12-01

    A 73-year-old woman complained of right chest discomfort. Chest X-ray during the follow-up for rheumatoid arthritis showed a mediastinal tumor. Chest computed tomography (CT) and magnetic resonance imaging (MRI) showed a 65-mm tumor in the right anterior mediastinum. A blood test showed high serum levels of CYFRA 21-1(29.8 ng/ml), white blood cells( WBC 10,800/µl), and C-reactive protein(CRP 16.1 mg/dl). Subsequently, inflammatory reactions improved, and the thymic tumor was resected. Histopathologically, the tumor was a type B2 thymoma with extensive coagulative necrosis. After resection, the serum CYFRA 21-1 level returned to the normal range. PMID:25434553

  6. GAMMA-RAY FLARING ACTIVITY FROM THE GRAVITATIONALLY LENSED BLAZAR PKS 1830–211 OBSERVED BY Fermi LAT

    Energy Technology Data Exchange (ETDEWEB)

    Abdo, A. A. [Center for Earth Observing and Space Research, College of Science, George Mason University, Fairfax, VA 22030 (United States); Ackermann, M.; Buehler, R. [Deutsches Elektronen Synchrotron DESY, D-15738 Zeuthen (Germany); Ajello, M. [Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720-7450 (United States); Allafort, A.; Bechtol, K.; Blandford, R. D.; Borgland, A. W.; Caliandro, G. A.; Cameron, R. A. [W. W. Hansen Experimental Physics Laboratory, Kavli Institute for Particle Astrophysics and Cosmology, Department of Physics and SLAC National Accelerator Laboratory, Stanford University, Stanford, CA 94305 (United States); Amin, M. A. [Kavli Institute for Cosmology and Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom); Baldini, L.; Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Barbiellini, G. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, I-34127 Trieste (Italy); Bastieri, D.; Buson, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Padova, I-35131 Padova (Italy); Bonamente, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Perugia, I-06123 Perugia (Italy); Bregeon, J. [Laboratoire Univers et Particules de Montpellier, Université Montpellier 2, CNRS/IN2P3, Montpellier (France); Brigida, M. [Dipartimento di Fisica " M. Merlin" dell' Università e del Politecnico di Bari, I-70126 Bari (Italy); Bulmash, D., E-mail: sara.buson@pd.infn.it, E-mail: stefano.ciprini@asdc.asi.it, E-mail: justin.finke@nrl.navy.mil, E-mail: dammando@ira.inaf.it, E-mail: stefano.ciprini@asdc.asi.it, E-mail: sara.buson@pd.infn.it, E-mail: justin.finke@nrl.navy.mil, E-mail: dammando@ira.inaf.it [Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02138 (United States); and others

    2015-02-01

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830–211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ∼3 years of observations and peaking on 2010 October 14/15 at 2.9 × 10{sup 50} erg s{sup –1}, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare, with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830–211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.

  7. Role of SV40 Integration Site at Chromosomal Interval 1q21.1 in Immortalized CRL2504 Cells

    Science.gov (United States)

    Liu, Jinglan; Kaur, Gurpreet; Zhawar, Vikramjit K.; Zimonjic, Drazen B.; Popescu, Nicholas C.; Kandpal, Raj P.; Athwal, Raghbir S.

    2009-01-01

    We have applied a functional gene transfer strategy to demonstrate the importance of viral integration site in cellular immortalization. The large tumor antigen of SV40 is capable of extending the cellular life span by sequestering tumor suppressor proteins pRB and p53 in virus-transformed human cells. Although SV40-LT is essential, it is not sufficient for cellular immortalization, suggesting that additional alterations in cellular genes are required to attain infinite proliferation. We demonstrate here that the disruption of human chromosomal interval at 1q21.1, by SV40 integration, can be an essential step for cellular immortalization. The transfer of a 150Kb bacterial artificial chromosome (BAC) clone, RP364B14, corresponding to viral integration site in CRL2504 cells, reverted their immortal phenotype. Interestingly, the BAC transfer clones of CRL-2504 cells displayed characteristics of either senescence as shown by β-galactosidase activity or apoptosis as revealed by positive staining with M30 cytoDeath antibody. The SV40 integration at 1q21.1, in the vicinity of epidermal differentiation complex genes, resulted in the down-regulation of the filaggrin (FLG) gene that is part of the epidermal differentiation complex. FLG gene expression was restored to its normal levels in BAC transfer senescent and apoptotic clones. Our results suggest that the disruption of native genomic sequence by SV40 may alter expression of genes involved in senescence and apoptosis by modulating chromatin structure. These studies imply that identification of genes located in the vicinity of viral integration sites in human cancers may be helpful in developing new diagnostic and therapeutic strategies. PMID:19789346

  8. Gamma-Ray Flaring Activity from the Gravitationally Lensed Blazar PKS 1830-211 Observed by Fermi LAT

    Science.gov (United States)

    Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Amin, M. A.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bonamente, E.; Borgland, A. W.; Bregeon, J.; Brigida, M.; Buehler, R.; Bulmash, D.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Cheung, C. C.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Corbet, R. H. D.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Drell, P. S.; Drlica-Wagner, A.; Favuzzi, C.; Finke, J.; Focke, W. B.; Fukazawa, Y.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Grenier, I. A.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Hayashida, M.; Hays, E.; Hughes, R. E.; Inoue, Y.; Jackson, M. S.; Jogler, T.; Jóhannesson, G.; Johnson, A. S.; Kamae, T.; Knödlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Mazziotta, M. N.; Mehault, J.; Michelson, P. F.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nemmen, R.; Nuss, E.; Ohno, M.; Ohsugi, T.; Paneque, D.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Reyes, L. C.; Ritz, S.; Romoli, C.; Roth, M.; Saz Parkinson, P. M.; Sgrò, C.; Siskind, E. J.; Spandre, G.; Spinelli, P.; Takahashi, H.; Takeuchi, Y.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Tronconi, V.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Werner, M.; Winer, B. L.; Wood, K. S.

    2015-02-01

    The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830-211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ~3 years of observations and peaking on 2010 October 14/15 at 2.9 × 1050 erg s-1, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare, with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830-211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.

  9. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  10. Decreased levels of serum cytokeratin 19 fragment CYFRA 21-1 predict objective response to chemotherapy in patients with non-small cell lung cancer.

    Science.gov (United States)

    Pang, Li; Wang, Jing; Jiang, Yanwen; Chen, Liangan

    2013-08-01

    Diagnostic tools capable of predicting early responses to chemotherapy are required to improve the individual management of cancer patients. The present study aimed to evaluate the prognostic significance of the serum tumor markers CYFRA 21-1, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), carbohydrate antigen (CA) 125, and CA 19-9 for predicting responses to different chemotherapy regimens in patients with non-small cell lung cancer (NSCLC). A total of 276 patients with postoperative stage I-IV NSCLC were retrospectively reviewed. The five tumor markers were measured before and after at least two cycles of chemotherapy using an electrochemiluminescent assay. Multivariate analysis revealed that performance status, age, postoperative stage and surgery were significantly associated with the response to chemotherapy. High baseline CYFRA 21-1 and CA 19-9 levels were associated with poor effectiveness of chemotherapy. Significant reductions in CYFRA 21-1 levels were associated with a positive response to various chemotherapy regimens. CEA, CA 125 and CA 19-9 expression was only associated with a positive response in patients receiving paclitaxel, docetaxel, pemetrexed and the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). NSE expression was only associated with a positive response to gemcitabine. Receiver operating characteristic (ROC) curve analysis indicated that CYFRA 21-1 is the most sensitive of the tumor markers in predicting the response to chemotherapy. Serum CYFRA 21-1 is a useful surrogate marker for predicting the response to different chemotherapy regimens used to treat NSCLC and is a more sensitive marker than CEA, CA125, CA19-9 and NSE. PMID:24137188

  11. CEA、NSE、CYFRA 21-1、Pro-GRP联合检测对肺癌诊断、预后判断的价值

    Institute of Scientific and Technical Information of China (English)

    陈平; 曾红梅

    2013-01-01

    目的:探讨CEA、NSE、CYFRA 21-1、Pro-GRP联合检测对肺癌诊断、预后判断的价值。方法选择肺癌患者90例(肺癌组)、肺部良性病变90例(良性组)及同期健康体检者90例(健康组),全部患者均空腹采集静脉血,检测血CEA、NSE、CYFRA 21-1、Pro-GRP水平,并进行组间比较。结果肺癌组患者血CEA、NSE、CYFRA 21-1、Pro-GRP水平明显高于良性组和健康组,差异有统计学意义(P<0.05)。不同肺癌分期患者血CEA、NSE、CYFRA 21-1、Pro-GRP水平比较差异显著(P<0.05),随着肺癌分期的进展,各指标水平均明显增加。结论 CEA、NSE、CYFRA 21-1、Pro-GRP联合检测对肺癌诊断有重要价值,其水平越高,肺癌分期越晚,患者预后越差,值得临床重视。

  12. 联检NSE、CYFRA21-1、D-二聚体、Fib在肺癌患者中的临床意义%Clinical significance of the combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen for the patients with lung cancer

    Institute of Scientific and Technical Information of China (English)

    谢颖; 贾张军; 张云生

    2014-01-01

    Objective To discuss the clinical significance of the combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen for lung cancer patients. Methods The levels of serum NSE and CYFRA21-1 were detected by electrochemical analysis in 256 lung cancer patients, 200 patients with benign lung diseases and 200 health subjects. The levels of plasma D-Dimer and Fibrinogen were detected by immunoturbidimetric assays. The relationship of NSE, CYFRA21-1, D-Dimer and Fibrinogen levels with the clinical stages of lung cancer was analyzed by statistics. Results The levels of NSE, CYFRA21-1, D-Dimer and Fibrinogen in patients with lung cancer were significantly higher than those in patients with benign lung diseases and healthy controls(PCYFRA21-1 > D-Dimer > Fibrinogen.CYFRA21-1 showed the highest sensitivity(69.0%) in squamous cellcarcinoma, and NSE showed the highest sensitivity(68.4%%) in smal celllung cancer. The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen might significantly improve the sensitivity for the diagnosis of lung cancer. The combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen showed the highest sensitivity(89.8%).NSE,CYFRA21-1, D-Dimer, Fibrinogen were positively related to the clinical stages of lung cancer. With the increasing of clinical stages, the levels of NSE,CYFRA21-1, D-Dimer, Fibrinogen in Ⅲ/Ⅳ stage were significantly higher than those in Ⅰ/Ⅱ stage(correlation coefficie nt(r)=0.315,0.425,0.669,0.523,). Conclusions The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen has an important clinical significance in the clinical diagnosis, differentiation, monitor and clinical stage of lung cancer.%联合检测神经元特异烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、D-二聚体(D-D)、Fib(纤维蛋白原),探讨其在肺癌患者中的临床意义。方法肺癌组(256例)、肺良性疾病组(200例)和正常对照组(200例)的血清NSE、CYFRA21-1水平采用电化学发光分析法检测,血

  13. Clinical significance in squamous cell lung cancer patients with serum CYFRA21-1 and SCC by ROC curve and cut-off theory%肺鳞癌患者血清CYFRA21-1和SCC检测及ROC曲线和截断点的理论分析

    Institute of Scientific and Technical Information of China (English)

    刘磊; 刘彬; 朱莉莉; 张薇

    2012-01-01

    目的:探讨血清细胞角蛋白19片段(CYFRA21-1)抗原和鳞癌抗原(SCC)对肺鳞癌的临床意义.方法:将研究对象分组,试验组为102例肺鳞癌患者,对照组为53例良性肺病患者.分别采用电化学发光法和酶联免疫法检测血清CYFRA21-1及SCC,测定值用t检验,率比较用x2检验.接受者工作特征(ROC)曲线及截断点选择理论评估CYFRA21-1及SCC的临床价值.结果:肺鳞癌组与良性肺病组CYFRA21-1和SCC水平差异有统计学意义;CYFRA21-1以3.3 ng/mL、SCC以1.5 ng/mL为诊断临界点,CYFRA21-1诊断肺鳞癌敏感性为57.84%,特异性为92.45%,准确性为69.68%,ROC曲线下面积为0.788;SCC诊断肺鳞癌敏感性为33.33%,特异性为92.45%,准确性为53.55%,ROC曲线下面积为0.691;CYFRA21-1诊断肺鳞癌最佳截断点为2.485或2.365 ng/mL,对应敏感性和特异性分别为65.7%、92.5%和67.6%、90.6%;SCC诊断肺鳞癌最佳截断点为0.55 ng/mL,对应敏感性和特异性分别为72.5%和62.3%.随肺鳞癌分期增高,CYFRA21-1和SCC浓度增高差异有统计学意义,CYFRA21-1敏感性增高差异有统计学意义,SCC敏感性无明显变化.结论:CYFRA21-1对肺鳞癌的诊断具有较高的临床价值,而SCC对肺鳞癌的诊断价值较低.%OBJECTIVE: To make further efforts and investigate the clinical significance of cytokeratin fragment 19 (CYFRA21-l)and squamous cell carcinoma antigen(SCC) of serum tumor markers (TM) in the diagnosis of squamous cell lung cancer patients. METHODS: The subjects were divided into two groups: the squamous cell lung cancer group (102 patients) and the benign lung disease group(53 patients). The electric chemisty irradiance was used to examine blood serum CYFRA21-1 and SCC was examined by ELISA. The results were examined by z-test, and the rate comparison were examined by Chi-square test. Receiver operator characteristic curve and cut-off choice theory were used to value the results. RESULTS: Significant

  14. CYFRA 21-1肿瘤标志物在宫颈鳞癌诊断和放疗疗效评价中的作用%The value of serum CYFRA 21-1 in cervical cancer patients treated with radiation therapy

    Institute of Scientific and Technical Information of China (English)

    邓湘; 修霞; 王德昌; 侯秀玉; 李高峰

    2007-01-01

    目的 探讨CYFRA21-1肿瘤标志物在宫颈鳞癌诊断和放疗疗效评价中的作用.方法 采用化学发光法检测68例宫颈鳞癌患者放疗前后血清中CYFRA21-1和常用肿瘤标志物鳞癌细胞相关性抗原SCC-Ag水平.结果 治疗前,CYFRA21-1检测阳性率52.9%,并随肿瘤分期而增加;放疗后,血清中CYFRA21-1检测水平明显下降,除2例放疗存在肿瘤转移的患者外,均达到正常水平;CYFRA21-1检测阳性率与SCC-Ag的相比,后者高于前者(P<0.05),但二者检测水平之间存在显著的相关性(相关系数r=0.65).结论 CYFRA21-1检测对宫颈鳞癌患者,特别是一些SCC-Ag检测结果正常的宫颈鳞癌患者的诊断预后和转归判断及放射治疗效果的评价具有重要价值.

  15. The CT Findings and the Peak SUV on PET/CT according to the Levels of Cyfra 21-1 and CEA in Patients with Non-Small Cell Lung Carcinoma

    International Nuclear Information System (INIS)

    We wanted to evaluate the CT findings and the peak SUV according to the levels of cyfra 21-1 and CEA in patients with non-small cell lung carcinoma (NSCLC). We evaluated the TNM staging, cell types, the CT findings and peak SUV of the NSCLC in 234 patients with NSCLC according to the tumor marker levels. The correlations of the CT findings and the peak SUV with the tumor markers were evaluated in 35 patients with stage I disease. The sensitivities of the combined tumor markers cyfra 21-1 and CEA in the NSCLC for each TNM staging (I-IV) were 48.5%, 66.7%, 78.3% and 84.3%, respectively (p<0.05). Cyfra 21-1 was more sensitive for squamous cell carcinoma and CEA was more sensitive for adenocarcinoma. The tumor size, tumor necrosis and peak SUV were greater in the NSCLC with an elevated cyfra 21-1 level than that in the NSCLC without an elevated cyfra 21-1 level (p<0.05). For stage I disease, the level of cyfra 21-1 was linearly correlated with the tumor size (r=0.54) and the peak SUV (r=0.46), and the level of CEA was high in the spiculated masses (p<0.05). The NSCLC with an elevated cyfra 21-1 level shows larger, more frequently necrosis and a higher peak SUV than the NSCLC without an elevated Cyfra 21-1 level. For stage 1 disease, the tumor size and peak SUV correlate with the level of cyfra 21-1, and spiculated masses show an elevated level of CEA

  16. The CT Findings and the Peak SUV on PET/CT according to the Levels of Cyfra 21-1 and CEA in Patients with Non-Small Cell Lung Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Jou, Sung Shick; Kim, Young Tong; Han, Jong Kyu; Kim, Hyung Hwan [Soonchunhyang University Cheonan Hospital, Cheonan (Korea, Republic of); Park, Jeong Mi; Park, Jai Soung [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of); Hwang, Jung Hwa [Soonchunhyang University Hospital, Seoul (Korea, Republic of)

    2009-10-15

    We wanted to evaluate the CT findings and the peak SUV according to the levels of cyfra 21-1 and CEA in patients with non-small cell lung carcinoma (NSCLC). We evaluated the TNM staging, cell types, the CT findings and peak SUV of the NSCLC in 234 patients with NSCLC according to the tumor marker levels. The correlations of the CT findings and the peak SUV with the tumor markers were evaluated in 35 patients with stage I disease. The sensitivities of the combined tumor markers cyfra 21-1 and CEA in the NSCLC for each TNM staging (I-IV) were 48.5%, 66.7%, 78.3% and 84.3%, respectively (p<0.05). Cyfra 21-1 was more sensitive for squamous cell carcinoma and CEA was more sensitive for adenocarcinoma. The tumor size, tumor necrosis and peak SUV were greater in the NSCLC with an elevated cyfra 21-1 level than that in the NSCLC without an elevated cyfra 21-1 level (p<0.05). For stage I disease, the level of cyfra 21-1 was linearly correlated with the tumor size (r=0.54) and the peak SUV (r=0.46), and the level of CEA was high in the spiculated masses (p<0.05). The NSCLC with an elevated cyfra 21-1 level shows larger, more frequently necrosis and a higher peak SUV than the NSCLC without an elevated Cyfra 21-1 level. For stage 1 disease, the tumor size and peak SUV correlate with the level of cyfra 21-1, and spiculated masses show an elevated level of CEA.

  17. 血清CYFRA21-1、NSE和CEA在肺癌诊断和评估预后中的临床价值%Clinical value of serum CYFRA 21-1, NSE and CEA in the diagnosis and prognosis of lung cancer

    Institute of Scientific and Technical Information of China (English)

    上官红; 肖伟; 董亮; 李玉; 田辉; 郑天郢

    2010-01-01

    目的 探讨血清肿瘤标志物细胞角蛋白片段21-1(CYFRA 21-1)、神经元特异性烯醇化酶(NSE)和癌胚抗原(CEA)在肺癌的早期诊断、肿瘤发展预测和预后判断方面的作用.方法 采用全自动电化学发光法对68例肺癌患者(肺癌组)、36例肺部良性病变患者(肺良性病组)和28例健康志愿者(健康组)进行血清CYFRA 21-1、NSE和CEA水平的检测,并分析CYFRA 21-1、NSE和CEA与肺癌TNM分期的相关性;采用Kaplan-Meier曲线分析患者生存期与CYFRA21-1、NSE和CEA水平的关系.结果 与肺良性病组和健康组相比,肺癌组血清CYFRA21-1、NSE和CEA水平明显升高(P<0.01),非小细胞肺癌的CYFRA21-1敏感度最高(78.72%),小细胞肺癌NSE敏感度最高(91.23%),与TMN分期呈明显正相关性(P<0.01),与生存期呈明显负相关性(P<0.01).结论 肺癌患者血清中CYFRA21-1、NSE和CEA水平均明显升高,提示该三项指标有望成为肺癌早期诊断、肿瘤发展预测和预后判断的重要生物学指标.

  18. A novel unbalanced de novo translocation der(5t(4;5(q26;q21.1 in adult T-cell precursor lymphoblastic leukemia

    Directory of Open Access Journals (Sweden)

    Kjeldsen Eigil

    2012-05-01

    Full Text Available Abstract We here describe a novel unbalanced de novo translocation der(5t(4;5(q26;q21.1 in a 39-year-old male diagnosed with acute T-cell lymphoblastic leukemia. Bone marrow (BM was massively infiltrated with 85 % highly proliferative polymorphic T-cell precursors. Immunologically, the malignant cells stained positive for CD7, CD34, intracytoplasmic CD3+, TdT + and negative for CD3 and CD5. G-banded chromosome analysis of BM cells showed the normal karyotype 46,XY[25] whereas BAC-based aCGH analysis revealed partial gain of 4q and partial loss of 5q. Multicolor karyotyping confirmed the presence of an unbalanced der(5t(4;5 as the sole structural abnormality. Subsequent high-resolution oligonucleotide-based aCGH analysis showed that the der(5t(4;5(q26;q21.1 resulted in partial trisomy of 4q26qter (117,719,015-190,613,014 and partial monosomy of 5q21.1qter (100,425,442-180,857,866 and that there was no indication of any gene disruptions resulting from the breakages. Interphase FISH analysis using BAC-based specific probes for 4q26 and 5q21.1 confirmed the breakpoints and revealed approximately 80 % abnormal cells accordingly. At 4q26 the MIR1973 gene is located centromeric to the breakpoint in the copy number neutral region and the TRAM1L1 gene is located within the gained region. At 5q21.1 the genes ST8SIA4 and MIR548p are located centromeric to the breakpoint and no known genes up to approximately 1 Mb telomeric to the breakpoint in the copy number loss region. Interestingly, only the gene ST8SIA4 at 5q21.1 have been implicated in T-cell regulation as it encodes one of the key enzymes for polysialysation of surface proteins on dendritic cells which are important regulators for T-cell proliferation. The der(5t(4;5 is thought to play a crucial role in the pathogenesis of acute T-ALL due to either gain of 4q, the loss of 5q, or deregulation of genes in proximity to the breakpoints.

  19. Computation of the chiral condensate using N{sub f}=2 and N{sub f}=2+1+1 dynamical flavors of twisted mass fermions

    Energy Technology Data Exchange (ETDEWEB)

    Cichy, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Poznan Univ. (Poland). Faculty of Physics; Garcia-Ramos, E. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Humboldt-Universitaet, Berlin (Germany); Jansen, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Shindler, A. [Forschungszentrum Juelich (Germany). IAS; Forschungszentrum Juelich (Germany). IKP; Forschungszentrum Juelich (Germany). JCHP; Collaboration: European Twisted Mass Collaboration

    2013-12-15

    We apply the spectral projector method, recently introduced by Giusti and Luescher, to compute the chiral condensate using N{sub f}=2 and N{sub f}=2+1+1 dynamical flavors of maximally twisted mass fermions. We present our results for several quark masses at three different lattice spacings which allows us to perform the chiral and continuum extrapolations. In addition we report our analysis on the O(a) improvement of the chiral condensate for twisted mass fermions. We also study the effect of the dynamical strange and charm quarks by comparing our results for N{sub f}=2 and N{sub f}=2+1+1 dynamical flavors.

  20. Myelodysplastic syndrome with a t(2;11)(p21;q23-24) and translocation breakpoint close to miR-125b-1.

    Science.gov (United States)

    Thorsen, Jim; Aamot, Hege Vangstein; Roberto, Roberta; Tjønnfjord, Geir E; Micci, Francesca; Heim, Sverre

    2012-10-01

    The upregulation of oncogenes and the formation of fusion genes are commonly observed in hematological malignancies with recurring balanced translocations. However, in some malignancies exhibiting balanced chromosomal rearrangements, neither oncogene deregulation nor generation of fusion genes appears to be involved, suggesting that other mechanisms are at play. In the rare myelodysplastic syndrome (MDS) containing a t(2;11)(p21;q23-24) translocation, breakpoints near a microRNA locus, miR-125b-1, in 11q24 have been suggested to be pathogenetically involved. Here we report the detailed mapping and sequencing of the breakpoint located only 2 kilobases from miR-125b-1 in an MDS patient with a t(2;11)(p21;q23-24).

  1. $K$ and $D$ oscillations in the Standard Model and its extensions from $N_f=2+1+1$ Twisted Mass LQCD

    CERN Document Server

    Carrasco, Nuria; Frezzotti, Roberto; Giménez, Vicent; Lubicz, Vittorio; Rossi, Giancarlo; Sanfilippo, Francesco; Tarantino, Cecilia

    2013-01-01

    We present the first $N_f=2+1+1$ results for the matrix elements of the operators describing neutral $K$ and $D$ mixing in the Standard Model and its extensions. The combination of maximally twisted sea quarks and Osterwalder-Seiler valence quarks ensures $\\mathcal{O}(a)$-improvement and continuum like renormalization pattern. We have used the $N_f=2+1+1$ dynamical quark gauge configurations generated by ETMC. Simulations include three lattice spacings in the interval $[0.06:0.09]$ fm and pseudoscalar meson masses in the range $[230:500]$ MeV. Our results are extrapolated to the continuum limit and to the physical quark masses. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme.

  2. Effect of radiotherapy on serum SCC, CEA, CRFRA21-1, TAG72, CA199 and lymphocyte subsets in patients with esophageal squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    Sha Sha; Bo Yu; Zhong-Qin Shu; Xiao-Wei Gu; Wei-Dong Mao; Lin-Yun Xia; Jian-Jun Qin

    2016-01-01

    Objective:To study the effect of radiotherapy on serum SCC, CEA, CRFRA21-1, TAG72, CA199 and lymphocyte subsets in patients with esophageal squamous cell carcinoma. Methods: A total of 60 patients with esophageal squamous cell carcinoma in our hospital from January 2013 to January 2016 were selected as experiment group and 40 healthy subjects were selected as control group. Patients in experiment group were treated with 6MV X-ray radiation therapy. Serum SCC, CEA, CRFRA21-1, TAG72, CA199 and the cell percentage of peripheral blood CD4+, CD8+ were compared in control group and the experimental group before and after 1 month radiotherapy.Results:Before treatment, the levels of serum SCC, CEA and CRFRA21-1 in the experimental group were significantly higher than those in the control group (P0.05). Before treatment, the cell percentage of peripheral blood CD4+, CD8+ and the ratio of CD4+/CD8+ in experimental group was significantly lower than that of the control group, the percentage of peripheral blood CD8+ in the experimental group was significantly higher than that in the control group (P0.05), and in the experimental group, the proportion of CD4+ cells and the tatio of CD4+/CD8+in peripheral blood was significantly lower than that of the control group, the proportion of CD8+ was significantly higher than that of the control group (P<0.05).Conclusions: Radiotherapy can significantly reduce the serum SCC, CEA, CRFRA21-1, TAG72 and CA199 levels of the patients with esophageal squamous cell carcinoma, but have less influence on the T lymphocyte subsets.

  3. Decreased levels of serum cytokeratin 19 fragment CYFRA 21-1 predict objective response to chemotherapy in patients with non-small cell lung cancer

    OpenAIRE

    Pang, Li; Jing WANG; Jiang, Yanwen; Chen, Liangan

    2013-01-01

    Diagnostic tools capable of predicting early responses to chemotherapy are required to improve the individual management of cancer patients. The present study aimed to evaluate the prognostic significance of the serum tumor markers CYFRA 21-1, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), carbohydrate antigen (CA) 125, and CA 19-9 for predicting responses to different chemotherapy regimens in patients with non-small cell lung cancer (NSCLC). A total of 276 patients with posto...

  4. Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/oropharyngeal squamous cell carcinoma

    OpenAIRE

    Yang, Kai

    2016-01-01

    Chuanshu Yuan, Kai Yang, Hong Tang, Dan Chen Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Background: At present, the research on serum tumor markers in the early diagnosis of malignant tumors has aroused widespread concern. The aim of this study was to investigate the diagnostic values of serum tumor markers cytokeratin 19 fragment (Cyfra21-1), squamous cell carcinoma antigen (SC...

  5. Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/oropharyngeal squamous cell carcinoma

    OpenAIRE

    Yuan CS; Yang K; Tang H; Chen D

    2016-01-01

    Chuanshu Yuan, Kai Yang, Hong Tang, Dan Chen Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Background: At present, the research on serum tumor markers in the early diagnosis of malignant tumors has aroused widespread concern. The aim of this study was to investigate the diagnostic values of serum tumor markers cytokeratin 19 fragment (Cyfra21-1), squamous cell carcinoma antigen (SCCAg)...

  6. Control of Y-211 content in bulk YBCO superconductors fabricated by a buffer-aided, top seeded infiltration and growth melt process

    Science.gov (United States)

    Namburi, Devendra K.; Shi, Yunhua; Palmer, Kysen G.; Dennis, Anthony R.; Durrell, John H.; Cardwell, David A.

    2016-03-01

    Bulk (RE)-Ba-Cu-O ((RE)BCO, where RE stands for rare-earth), single grain superconductors can trap magnetic fields of several tesla at low temperatures and therefore can function potentially as high field magnets. Although top seeded melt growth (TSMG) is an established process for fabricating relatively high quality single grains of (RE)BCO for high field applications, this technique suffers from inherent problems such as sample shrinkage, a large intrinsic porosity and the presence of (RE)2BaCuO5 (RE-211)-free regions in the single grain microstructure. Seeded infiltration and growth (SIG), therefore, has emerged as a practical alternative to TSMG that overcomes many of these problems. Until now, however, the superconducting properties of bulk materials processed by SIG have been inferior to those fabricated using the TSMG technique. In this study, we identify that the inferior properties of SIG processed bulk superconductors are related to the presence of a relatively large Y-211 content (˜41.8%) in the single grain microstructure. Controlling the RE-211 content in SIG bulk samples is particularly challenging because it is difficult to regulate the entry of the liquid phase into the solid RE-211 preform during the infiltration process. In an attempt to solve this issue, we have investigated the effect of careful control of both the infiltration temperature and the quantity of liquid phase powder present in the sample preforms prior to processing. We conclude that careful control of the infiltration temperature is the most promising of these two process variables. Using this knowledge, we have fabricated successfully a YBCO bulk single grain using the SIG process of diameter 25 mm that exhibits a trapped field of 0.69 T at 77 K, which is the largest value reported to date for a sample fabricated by the SIG technique.

  7. CEA 、NSE、 Cyfra21-1在良恶性胸腔积液诊断中的意义

    Institute of Scientific and Technical Information of China (English)

    刘娟

    2015-01-01

    目的:探讨CEA、NSE、Cyfra 21-1在良恶性胸腔积液诊断中的意义.方法:收集已确诊的胸腔积液病例83例,分成良性积液组(40例)和恶性积液组(43例),分别检测两组胸腔积液中CEA、NSE、Cyfra 21-1的水平,并进行组间统计学分析.结果:恶性积液组CEA水平和阳性率与良性积液组比较,差异有统计学意义(P<0.05);恶性积液组Cyfra 21-1水平与良性积液组比较,差异有统计学意义(P<0.05),但阳性率比较差异无统计学意义(P>0.05).恶性积液组NSE水平和阳性率与良性积液组比较,差异无统计学意义(P>0.05).结论:CEA检测在良恶性胸腔积液诊断中有重要意义,NSE、Cyfra 21-1检测在良恶性胸腔积液鉴别诊断中特异性不高.

  8. 头颈鳞状细胞癌患者CYFRA 21-1的检测及其临床意义

    Institute of Scientific and Technical Information of China (English)

    邓燕飞; 陈平; 林永志; 乐家振; 庄佩耘; 邬晓力; 余明强; 杨海斌; 洪拥军; 高明华

    2002-01-01

    @@ 为明确CYFRA 21-1(CYFRA)在头颈鳞状细胞癌(以下简称鳞癌)中的临床应用价值,我们运用电化学发光免疫分析技术(electrochemiluminescent immunoassay, ECLIA)检测头颈鳞癌患者CYFRA的血清水平,并分析其临床意义.

  9. 慈菇对CCl4致大鼠肝纤维化血清cyfra21-1和CEA影响的探讨%The Effect of Sagittaria Agittifolia on Changes of Cyfra21-1 and CEA in Rats of CCl4 Experimental Liver Fibrosis

    Institute of Scientific and Technical Information of China (English)

    吴小南; 汪家梨; 盛健; 黄建宏

    2001-01-01

    目的探讨慈菇对CCl4致大鼠肝纤维化的干预作用.方法对5月龄Wistar大鼠,用CCl4染毒致大鼠形成肝组织纤维化,以ELISA法和放射免疫分析法检测大鼠血清cyfra21-1和CEA的浓度的变化,并观察慈菇的干预效果.结果染毒组大鼠cyfra21-1和CEA明显高于对照组,慈菇可减轻CCl4致大鼠肝纤维化程度并减少cyfra21-1和CEA的产生.结论大鼠肝纤维化后血清cyfra21-1和CEA升高,提示慈菇干预作用的机理值得深入探讨.

  10. 头颈鳞状细胞癌患者血清Cyfra21-1检测的临床意义%Clinical significance of Cyfra21-1 in patients with squamous cell carcinoma of the head and neck

    Institute of Scientific and Technical Information of China (English)

    徐先发; 谭静

    2011-01-01

    OBJECTIVE To evaluate the clinical significance of Cyfra 21-1 in patients with head and neck squamous cell carcinoma (HNSCC) . METHODS Before and after treatment, the serum concentration of Cyfra 21-1 was measured by ELISA assay in 60 patients with HNSCC, 40 patients with benign tumors of the thyroid. Also 20 healthy adults were included in this reseach as controls. Statistical analysis was performed using SPSS11.5 statistical package. RESULTS Serum levels of Cyfra21-1 were (6.49±2.90) ng/ml in preoperative patients with HNSCC, (3.39 ±1.45) ng/ml in postoperative patients with HNSCC, (2.01 ± 0.83) ng/ml in preoperative patients with benign tumors of the thyroid, (1.98±0.85) ng/ml in postoperative patients with benign tumors of the thyroid and (1.90 ± 0.69) ng/ml in control group, respectively. Serum levels of Cyfra21-1 in preoperative patients with HNSCC were significantly higher than those of benign tumors of the thyroid (t=4.69, P0.05) .After operation, levels of Cyfra21-1 in HNSCC decreased significantly (t=3.57, P0.05).The serum concentrations of Cyfra 21-1 in preoperative patients with HNSCC were statistically correlated with the T-stage of the disease(t=2.35, P0.05) or gender (t=1.32, P>0.05) . In 4 patients with local tumor recurrence during follow-up, serum Cyfra21-1 levels showed a significant increase compared with the levels after surgery. At the cutoff value of 3.69 ng/ml, the diagnostic sensitivity and specificity of Cyfra 21-1 for HNSCC were 80.0% and 91.7%, respectively. CONCLUSION CYFRA 21-1 can be used as an useful tumor marker of HNSCC in diagnosis,evaluation of therapeutic effect, monitoring of tumorrecurrence and the prognosis.%目的 探讨血清Cyfra21-1在头颈鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)中的临床意义.方法 采用双抗体夹心ELISA法对随机选取的60例HNSCC患者,40例甲状腺良性肿瘤患者,20名健康对照组进行血清Cyfra2l-1检测.应用SPSS 11.5统计软

  11. 血清CYFRA21-1、NSE和CEA对晚期非小细胞肺癌NP方案化疗疗效的预测价值%Predictive and Therapeutic Value of CYFRA 21-1、NSE and CEA for Non-small Cell lung Cancer with NP Chemotherapy

    Institute of Scientific and Technical Information of China (English)

    葛春艳; 王岩静; 刘家驹; 李梅

    2012-01-01

    目的:探讨血清肿瘤标志物CYFRA 21-1、NSE和CEA对晚期非小细胞肺癌化疗疗效的预测价值.方法:选取60例经病理证实的初治晚期非小细胞肺癌患者,予NP方案(盖诺 +顺铂)一线化疗,于治疗开始前及化疗两周期后抽取患者外周静脉血,采用ELISA法检测患者血清CEA、NSE和CYFRA 21-1的浓度.结果:NP方案化疗前后血清CYFRA 21-1、NSE和CEA的表达水平均明显降低,P<0.05有统计学意义.结论:血清CYFRA 21-1、NSE和CEA的表达水平可以作为晚期肺癌评价疗效和监测复发的理想选择.

  12. LTA ,CEA,NSE,Cyfra 21-1 对肺癌诊断价值的探讨%Diagnostic Value of Non-small-cell Lung tumor Antigen (LTA),Carcinoembryonic Anitigen (CEA), Neuron-specific Enolase (NSE)and Cytokeratin Fragment 19(Cyfra21-1) in Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    周彩存; 谈立松

    2001-01-01

    目的探讨LTA、CEA、NSE和Cyfra21-1对肺癌诊断价值.方法清晨空腹抽取临床确诊肺癌患者124例、转移性肺癌9例和良性肺部疾病34例患者静脉血7ml,分别用放射免疫法和乳胶凝集试验法,检测血清中上述癌性标志物水平.结果:LTA、CEA、NSE和Cyfra21-1,在肺癌的阳性率分别为60%、8%、31%和43%;特异性分别为88%、100%、84%和97%,CEA和Cyfra21-1较高;阳性率和敏感性组间差异有统计学意义.LTA对肺癌细胞类型和是否手术无诊断意义.结论LTA对肺癌具有一定的诊断价值,但特异性差于Cyfra21-1;多种癌性标志物同时检测有助提高阳性率.

  13. The value of CYFRA 21-1 in diagnosis of non-small cell lung cancer with pleural effusion%CYFRA 21-1对非小细胞肺癌胸腔积液的诊断价值

    Institute of Scientific and Technical Information of China (English)

    唐华平; 李双保; 魏涛; 葛云洁; 孙美红

    2000-01-01

    目的探讨非小细胞肺癌标记物(CYFRA 21-1)对非小细胞肺癌(NSCLC)胸腔积液的诊断价值.方法用放免法测定了非小细胞肺癌,小细胞肺癌(SCLC)及结核性胸膜炎的胸腔积液CYFRA 21-1水平.结果非小细胞肺癌胸腔积液的CYFRA 21-1水平,无论细胞学阳性或阴性,均显著高于小细胞肺癌及结核性胸膜炎的胸腔积液组(P<0.01).结论检测胸腔积液CYFRA 21-1对非小细胞肺癌胸腔积液的诊断有重要价值.

  14. Clinical value of CEA, NSE and CYFRA21-1 combined detection in differential diagnosis of lung cancer%血清肿瘤标志物CEA、NSE、CYFRA21-1联合检测在肺癌鉴别诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    左建新; 刘阳; 周乃康

    2006-01-01

    目的:研究肺癌及肺部良性疾病患者血清CEA、NSE、CYFRA21-1的水平,探讨其在肺癌鉴别诊断中的价值.方法:检测122例肺癌和37例良性肺病患者血清中CEA、NSE、CYFRA21-1的水平.结果:肺癌组CEA、NSE、CYFRA21-1测定值明显高于肺良性病变组(P<0.05), 3项联合检测的灵敏度为51.64%,明显优于单项检测.3项肿瘤标记物测定水平和灵敏度与病理类型有关;血CEA以腺癌最高;血NSE以小细胞肺癌最高;血CYFRA 21-1以鳞癌最高.结论: 3项肿瘤标记物联合检测有利于肺癌的鉴别诊断.

  15. CEA与CYFRA-21-1联合检测恶性胸腔积液对肺部恶性肿瘤的临床意义

    Institute of Scientific and Technical Information of China (English)

    聂宇波

    2005-01-01

    良恶性胸液鉴别较为困难,癌胚抗原(CEA)、细胞角蛋白K19的片段(CYFRA21-1)都是意义较明确的肿瘤标志物.本文联合检测胸液CEA与CYFRA21-1,旨在探讨其对良恶性胸液的鉴别诊断价值.

  16. A novel form of distal hereditary motor neuronopathy maps to chromosome 9p21.1-p12.

    Science.gov (United States)

    Christodoulou, K; Zamba, E; Tsingis, M; Mubaidin, A; Horani, K; Abu-Sheik, S; El-Khateeb, M; Kyriacou, K; Kyriakides, T; Al-Qudah, A K; Middleton, L

    2000-12-01

    Distal hereditary motor neuronopathies (dHMNs) form a heterogeneous group of rare disorders characterized by distal weakness and wasting in the limbs with no significant sensory involvement. Harding has classified dHMNs into seven categories based on clinical and genetic criteria. We report a novel form of autosomal recessive dHMN in 7 consanguineous families located in the Jerash region of Jordan. Onset of the disease is between 6 and 10 years of age and is characterized by weakness and atrophy of the lower limbs associated with pyramidal features. Within 2 years, symptoms progress to the upper limbs. Neurophysiological studies typically show normal conduction velocities, reduced compound motor action potential amplitudes, normal sensory nerve action potentials, and chronic neurogenic changes on needle electromyography. No significant abnormalities are seen on sural nerve biopsy. We call this novel form of dHMN Jerash hereditary motor neuronopathy. We studied the families at the molecular genetic level and mapped the Jerash hereditary motor neuronopathy gene to an approximately 0.54-cM region on chromosome 9p21.1-p12, flanked by microsatellite polymorphic marker loci D9S1845 and D9S1791. A maximum LOD score of 19.80 at theta = 0.001 was obtained between the disease and locus D9S1878. PMID:11117544

  17. Up, down, strange and charm quark masses with Nf=2+1+1 twisted mass lattice QCD

    Directory of Open Access Journals (Sweden)

    N. Carrasco

    2014-10-01

    Full Text Available We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf=2+1+1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210–450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI′-MOM method. The results for the quark masses converted to the MS¯ scheme are: mud(2 GeV=3.70(17 MeV, ms(2 GeV=99.6(4.3 MeV and mc(mc=1.348(46 GeV. We obtain also the quark mass ratios ms/mud=26.66(32 and mc/ms=11.62(16. By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate mu/md=0.470(56, leading to mu=2.36(24 MeV and md=5.03(26 MeV.

  18. The electric dipole moment of the neutron from $N_f=2+1+1$ twisted mass fermions

    CERN Document Server

    Alexandrou, Constantia; Constantinou, Martha; Hadjiyiannakou, Kyriakos; Jansen, Karl; Koutsou, Giannis; Ottnad, Konstantin; Petschlies, Marcus

    2015-01-01

    We extract the neutron electric dipole moment (nEDM) $ \\vert \\vec{d}_n \\vert $ on configurations produced with $N_f=2+1+1$ twisted mass fermions with lattice spacing of $a \\simeq 0.082$ fm and a light quark mass that corresponds to $M_{\\pi} \\simeq 373$ MeV. We do so by evaluating the $CP$-odd form factor $F_3$ for small values of the $CP$-violation parameter $\\theta$ in the limit of zero momentum transfer. This limit is extracted using the usual parametrization but in addition position space methods. The topological charge is computed via cooling and gradient flow using the Wilson, Symanzik tree-level improved and Iwasaki actions for smoothing. We obtain consistent results for all choices of smoothing procedures and methods to extract $F_3$ at zero momentum transfer. For the ensemble analyzed we find a value of nEDM of $\\vert \\vec{d}_n \\vert / \\theta = -0.045(6)(1) {\\rm e} \\cdot {\\rm fm}$.

  19. The effect of film thickness on critical properties of YBCO film fabricated by TFA-MOD using 211-process

    International Nuclear Information System (INIS)

    YBCO films were fabricated by the TFA-MOD method using the '211-process', and the effects of the film thickness on phase formation, microstructure, texture evolution, and critical properties were evaluated. Various film thicknesses ranging from 0.41 μm to 2.14 μm were obtained by repeating the dip coating and calcining processes one to five times. The critical properties varied significantly with the film thickness. The Ic increased from 35 to 105 A/cm-width with increasing the film thickness from 0.41 μm to 1.17 μm. On the other hand, the corresponding Jc remained almost constant in the range of 0.76-0.90 MA/cm2. With further increases in thickness, these values decreased drastically, which was attributed to the degraded microstructure, i.e., the formation of BaF2 and a-axis grains and degraded texture and surface morphology arising from the insufficient heat treatment time. It is believed that the optimum thickness for improving both the Ic and Jc values is approximately 1.17 μm

  20. An ALMA Early Science survey of molecular absorption lines toward PKS1830-211 -- Analysis of the absorption profiles

    CERN Document Server

    Muller, S; Guelin, M; Gerin, M; Aalto, S; Beelen, A; Black, J H; Curran, S J; Darling, J; Dinh-V-Trung,; Garcia-Burillo, S; Henkel, C; Horellou, C; Martin, S; Marti-Vidal, I; Menten, K M; Murphy, M T; Ott, J; Wiklind, T; Zwaan, M A

    2014-01-01

    We present the first results of an ALMA spectral survey of strong absorption lines for common interstellar species in the z=0.89 molecular absorber toward the lensed blazar PKS1830-211. The dataset brings essential information on the structure and composition of the absorbing gas in the foreground galaxy. In particular, we find absorption over large velocity intervals (gtrsim 100 km/s) toward both lensed images of the blazar. This suggests either that the galaxy inclination is intermediate and that we sample velocity gradients or streaming motions in the disk plane, that the molecular gas has a large vertical distribution or extraplanar components, or that the absorber is not a simple spiral galaxy but might be a merger system. The number of detected species is now reaching a total of 42 different species plus 14 different rare isotopologues toward the SW image, and 14 species toward the NE line-of-sight. The abundances of CH, H2O, HCO+, HCN, and NH3 relative to H2 are found to be comparable to those in the G...

  1. Pinning properties of Y211 added cold top-seeded YBCO grown on Y2O3 layer

    Science.gov (United States)

    Çakır, Bakiye; Duman, Şeyda; Aydıner, Alev

    2016-04-01

    In this study, samples having different composition were prepared with the cold top seeding-melt-growth (TSMG) process by using Nd123 seed. Y2O3 buffer layer was placed to bottom of the pellets consist of Y123: Y211 powder mixtures. Two samples were fabricated in stoichiometric ratios of 1:0 and 1:0.4 labeled as Y0 and Y40, respectively. The Tc onset values of Y0 and Y40 were found to be 93.4 and 93.6 K at 0 T, respectively. The dependence of the effective activation energy U of the flux pinning on the magnetic field and temperature of the sample were determined using the Arrhenius activation energy law from the resistivity curves. The magnetization measurements were performed using a vibrating sample magnetometer (VSM) at 30, 50 and 77 K. The critical current densities (J c) for Y0 and Y40 samples were determined to be 5.1×103 and 3.7×103 A/cm2 at 77 K in 0 T, respectively. The normalized pinning force density versus the reduced field was examined at different temperatures to determine the pinning mechanism.

  2. Congenital transmission of Trypanosoma cruzi in central Brazil. A study of 1,211 individuals born to infected mothers.

    Science.gov (United States)

    Luquetti, Alejandro O; Tavares, Suelene Brito do Nascimento; Siriano, Liliane da Rocha; Oliveira, Rozângela Amaral de; Campos, Dayse Elizabeth; de Morais, Cicilio Alves; de Oliveira, Enio Chaves

    2015-05-01

    Transmission of Trypanosoma cruzi during pregnancy is estimated to occur in less than 20% of infected mothers; however, the etiopathogenesis is not completely understood. The Centre for Studies on Chagas Disease provides confirmation of T. cruzi infection for individuals living in central Brazil. In this retrospective hospital-based study, all requests for diagnosis of T. cruzi infection in individuals less than 21 years old from 1994-2014 were searched. We end with 1,211 individuals and their respective infected mothers. Congenital transmission of infection was confirmed in 24 individuals (2%) in central Brazil, an area where the main T. cruzi lineage circulating in humans is TcII. This low prevalence of congenital Chagas disease is discussed in relation to recent findings in the south region of Brazil, where TcV is the main lineage and congenital transmission has a higher prevalence (approximately 5%), similar to frequencies reported in Argentina, Paraguay and Bolivia. This is the first report to show geographical differences in the rates of congenital transmission of T. cruzi and the relationship between the prevalence of congenital transmission and the type of Tc prevalent in each region.

  3. Polyhydroquinone-graphene composite as new redox species for sensitive electrochemical detection of cytokeratins antigen 21-1.

    Science.gov (United States)

    Wang, Huiqiang; Rong, Qinfeng; Ma, Zhanfang

    2016-01-01

    Polyhydroquinone-graphene composite as a new redox species was synthesized simply by a microwave-assisted one-pot method through oxidative polymerization of hydroquinone by graphene oxide, which exhibited excellent electrochemical redox activity at 0.124 V and can remarkably promote electron transfer. The as-prepared composite was used as immunosensing substrate in a label-free electrochemical immunosensor for the detection of cytokeratins antigen 21-1, a kind of biomarker of lung cancer. The proposed immunosensor showed wide liner range from 10 pg mL(-1) to 200 ng mL(-1) with a detection limit 2.3 pg mL(-1), and displayed a good stability and selectivity. In addition, this method has been used for the analysis of human serum sample, and the detection results showed good consistence with those of ELISA. The present substrate can be easily extended to other polymer-based nanocomposites. PMID:27464571

  4. The electric dipole moment of the neutron from N{sub f}=2+1+1 twisted mass fermions

    Energy Technology Data Exchange (ETDEWEB)

    Alexandrou, C.; Athenodorou, A.; Constantinou, M. [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics; Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Hadjiyiannakou, K. [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics; Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; George Washington Univ., Washington, DC (United States). Dept. of Physics; Jansen, K. [DESY Zeuthen (Germany). NIC; Koutsou, G. [Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Ottnad, K. [Cyprus Univ., Nicosia (Cyprus). Dept. of Physics; Bonn Univ. (Germany). Helmholtz-Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics; Petschlies, M. [Cyprus Institute, Nicosia (Cyprus). Computation-based Science and Technology Research Center; Bonn Univ. (Germany). Helmholtz-Institut fuer Strahlen- und Kernphysik and Bethe Center for Theoretical Physics

    2015-11-15

    We extract the neutron electric dipole moment (nEDM) vertical stroke vector d{sub n} vertical stroke on configurations produced with N{sub f}=2+1+1 twisted mass fermions with lattice spacing of a ≅0.082 fm and a light quark mass that corresponds to M{sub π} ≅ 373 MeV. We do so by evaluating the CP-odd form factor F{sub 3} for small values of the CP-violation parameter θ in the limit of zero momentum transfer. This limit is extracted using the usual parametrization but in addition position space methods. The topological charge is computed via cooling and gradient flow using the Wilson, Symanzik tree-level improved and Iwasaki actions for smoothing. We obtain consistent results for all choices of smoothing procedures and methods to extract F{sub 3} at zero momentum transfer. For the ensemble analyzed we find a value of nEDM of vertical stroke vector d{sub n} vertical stroke /θ=0.045(6)(1) e.fm.

  5. THE VALUE OF TELOMERASE ACTIVITY AND LEVEL OF CYFRA 21-1 IN DIFFERENTIAL DIAGNOSIS BETWEEN BENIGN AND MALIGNANT PLEURAL EFFUSION%端粒酶和CYFRA 21-1对良恶性胸腔积液的鉴别价值

    Institute of Scientific and Technical Information of China (English)

    李红梅; 于壮; 顾华丽; 胡晓晓

    2010-01-01

    目的 研究端粒酶和细胞角蛋白19片段(CYFRA 21-1)测定对鉴别良、恶性胸腔积液的价值.方法 采用端粒重复序列扩增-酶联免疫吸附实验法(TRAP-PCR-ELISA)和酶免疫分析法(EIA),分别测定80例恶性胸腔积液和50例良性胸腔积液中的端粒酶活性和CYFRA 21-1水平.结果 胸腔积液中端粒酶活性和CYFRA 21-1的阳性率在恶性胸腔积液组分别为77.5%(62/80)和60.0%(48/80),在良性胸腔积液组分别为6.0%(3/50)和22.0%(11/50),两组比较差异有显著性(χ2=62.921、17.925,P均<0.001).端粒酶活性测定诊断恶性胸腔积液的灵敏度为77.5%(62/80),特异度为94.0%(47/50);CYFRA 21-1诊断的灵敏度60.0% (48/80),特异度78.0%(39/50),两组比较差异有显著性(χ2=4.103、5.316,P<0.05).两者联合检测的灵敏度为90.0%(72/80),特异度为82.0%(41/50),联合检测的灵敏度高于端粒酶和CYFRA 21-1单项检测(χ2=4.592、19.201,P<0.05、0.001).结论 端粒酶和CYFRA 21-1测定对鉴别良恶性胸腔积液均有一定的价值,其中端粒酶测定的灵敏度和特异度较CYFRA 21-1高,两者联合测定可提高诊断准确率.

  6. Analysis in patients of the Hospital A.C. Camargo of two tumors markers: CA-72.4 and CYFRA-21.1

    International Nuclear Information System (INIS)

    The behavior of two tumor markers, CA-72.4 and CYFRA-19.9 was analysed in patients of the Hospital A.C. Camargo. The measurement of CA-272.4 serum levels was performed by an automated chemo luminescence assay in 49 patients and proved useful in the two groups analyzed, patients with esophageal tumors and with gastric tumors. In both cases, there was an increase in sensitivity when measurements of this marker was added to that of carcinoembryonic antigen (CEA) and of CA-19.9. The most sensitive associations were of CA-72.4 and CA-19.9 for esophageal tumors and of CA-72.4 and CEA for the gastric tumors. The maker CYFRA-21.1 was analyzed by a radioimmunoassay in 102 normal blood donors and in 20 patients with lung cancer. Among these, CYFRA-21.1 was altered in 55% of the cases. Therefore, CYFRA-21.1 could be considered, as the neuron-specific enolase (NSE), very useful tool for the follow-up lung cancer patients. (author)

  7. Synthesis and biological evaluation in mice of (2-[11C]methoxy)-6',7'-dihydrorotenol, a second generation rotenoid for marking mitochondrial complex I activity

    International Nuclear Information System (INIS)

    Evidence has accumulated suggesting that impairment of the function of the complexes of the mitochondrial respiratory chain might be involved in the pathology of neurological diseases including Parkinson's and Huntington's diseases. Recently we reported the synthesis of (2-[11C]methoxy)rotenone ([11C]ROT) as a tool for in vivo studies of complex I. In an effort to develop a complex I imaging radiotracer which might be easier to synthesize and less likely to be metabolized, we prepared (2-[11C]methoxy)-6',7'-dihydrorotenol ([11C]DHROT). The radiotracer was synthesized by [11C]methylation of 2-O-desmethyl-6',7'-dihydrorotenol under basic [11C]alkylation conditions. (2-[11C]Methoxy)-6',7'-dihydrorotenol was produced in 30-35% radiochemical yields (decay corrected), with synthesis times shorter than 35 min. Radiochemical purities were over 95% and specific activities averaged 1000 Ci/mmol. The brain distributions of [11C]ROT and [11C]DHROT were investigated in mice after intravenous injections. For both radiotracers, distribution of radioactivity was similar in all brain regions examined. However, significantly higher uptake was observed with [11C]DHROT than with [11C]ROT, indicating that the alterations introduced in the structure of rotenone during the design of [11C]DHROT resulted in a tracer with greater brain barrier permeability

  8. The missense Thr211Pro mutation in the factor X activation peptide of a bleeding patient causes molecular defect in the clotting cascade.

    Science.gov (United States)

    Ding, Qiulan; Shen, Yiping; Yang, Likui; Wang, Xuefeng; Rezaie, Alireza R

    2013-07-01

    Factor X (FX) is a vitamin K-dependent coagulation zymogen, which upon activation to factor Xa assembles into the prothrombinase complex to activate prothrombin to thrombin. FX can be activated by either factor VIIa-tissue factor or factor IXa-factor VIIIa in extrinsic and intrinsic pathways, respectively. In this study, we identified a bleeding patient with moderate FX deficiency who exhibits a clotting defect only in the intrinsic pathway. Exome sequencing revealed that the patient carries a novel homozygous missense mutation that results in substitution of Thr211 with Pro in the activation peptide of FX. Thr211 is the site of an O-linked glycosylation in the activation peptide of FX. We postulated that the lack of this post-translational modification specifically impacts the activation of FX by intrinsic Xase, thereby impairing thrombin generation in the subject. To test this hypothesis, we expressed both wild-type FX and FX containing this mutation in mammalian cells and following the purification of the zymogens to homogeneity characterized their properties in both purified and plasma-based assay systems. Analysis of the results suggests that Thr211 to Pro substitution renders the FX mutant a poor substrate for both physiological activators, however, at physiological concentration of the substrate, the clotting defect manifest itself only in the intrinsic pathway, thus explaining the bleeding phenotype for the patient carrying this mutation. PMID:23677006

  9. CEA、NSE和CYFRA21-1三项联合检测在肺癌诊断中的临床价值

    Institute of Scientific and Technical Information of China (English)

    蔡锦洪

    2012-01-01

    目的 探讨血清肿瘤标志物CEA、NSE、CYFRA 21-1 在肺癌诊断中的价值.方法 选择62 例已确诊肺癌患者,62 例良性肺部疾病者以及62 例健康人,对这三组人群肿瘤标志物进行检测,包括:癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白21-1 片段(CYFRA21-1)等.结果 肺癌组的肿瘤标志物检测结果 与肺部良性疾病组和健康人群组不同,差异具有统计学意义(P < 0.05).结论 多种血清肿瘤标志物联合检测能有效地对肺癌患者及时作出诊断,可明显提高肺癌诊断的阳性率.

  10. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    Directory of Open Access Journals (Sweden)

    Isabella Coimbra Wagner

    2007-04-01

    Full Text Available OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA, fragmento da citoqueratina 19 (CYFRA21-1 e antígeno glicosídico associado a tumor 15-3 (CA 15-3 em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi realizada por eletroquimioluminescência. A sensibilidade foi determinada sob a condição de que a especificidade fosse > 90%. RESULTADOS: Foram diagnosticados 36 casos malignos (42,4%, 30 benignos (35,3%; em 19 pacientes (22,3%, o diagnóstico foi inconclusivo. Nos casos malignos, os valores de CEA e CYFRA21-1 foram maiores no líquido pleural do que no sangue, fato não observado para o CA 15-3. Nos casos benignos, os valores do CYFRA21-1 foram maiores no líquido pleural do que no soro, enquanto que para o CEA e o CA 15-3, ocorreu o oposto. Todos os marcadores apresentaram diferença significativa entre os casos malignos e benignos, em líquido pleural e soro. Foi encontrada sensibilidade para CEA, CYFRA21-1 e CA 15-3 no líquido pleural de 69,4%, 69,4% e 66,7%, respectivamente e quando associados, foi 80,6%. No soro, a sensibilidade foi 57,1, 71,4 e 48,6% para CEA, CYFRA21-1 e CA 15-3, respectivamente, e quando associados, foi 77%. CONCLUSÃO: Os resultados sugerem que a utilização desses marcadores pode ser útil na diferenciação entre derrames pleurais malignos e benignos.OBJECTIVE: To determine the levels of the tumor markers carcinoembryonic antigen (CEA, cytokeratin 19 fragment (CYFRA21-1 and carbohydrate antigen 15-3 (CA 15-3 in the blood and pleural fluid of patients with benign or malignant pleural effusion, evaluating the sensitivity of each marker in these fluids. METHODS: We prospectively evaluated 85 patients with pleural effusion. The

  11. 血清CK19-2G2、CYFRA 21-1和CA-125联合检测在肺癌诊断中的应用%Value of serum CK19-2G2,CYFRA 21-1 and CA-125 detecting in lung cancer diagnosis

    Institute of Scientific and Technical Information of China (English)

    刘杰; 李道堂; 陈彦卿; 李涛

    2009-01-01

    目的 探讨血清CK19-2G2、CYFRA 21-1、CA-125联合检测对肺癌的诊断价值.方法 采用放射免疫法检测了110例肺癌患者、70例肺部良性疾病患者及30例健康体检者的血清CK19-2G2、CYFRA 21-1和CA-125.结果 肺癌组血清CK19-2G2、CYFRA 21-1和CA-125水平及阳性检出率显著高于正常对照组和肺部良性疾病组(P均<0.01).CK19-2G2、CYFRA 21-1在肺鳞癌中呈高表达,CA-125在肺腺癌中呈高表达.三者联合检测肺癌的灵敏度为84.5%,特异性为77%.结论 血清CK19-2G2、CYFRA 21-1、CA-125水平在肺癌的诊断中有应用价值.三者联合检测诊断肺癌灵敏度高.

  12. High-throughput microRNA (miRNAs arrays unravel the prognostic role of MiR-211 in pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Elisa Giovannetti

    Full Text Available BACKGROUND: Only a subset of radically resected pancreatic ductal adenocarcinoma (PDAC patients benefit from chemotherapy, and identification of prognostic factors is warranted. Recently miRNAs emerged as diagnostic biomarkers and innovative therapeutic targets, while high-throughput arrays are opening new opportunities to evaluate whether they can predict clinical outcome. The present study evaluated whether comprehensive miRNA expression profiling correlated with overall survival (OS in resected PDAC patients. METHODOLOGY/PRINCIPAL FINDINGS: High-resolution miRNA profiles were obtained with the Toray's 3D-Gene™-miRNA-chip, detecting more than 1200 human miRNAs. RNA was successfully isolated from paraffin-embedded primary tumors of 19 out of 26 stage-pT3N1 homogeneously treated patients (adjuvant gemcitabine 1000 mg/m(2/day, days-1/8/15, every 28 days, carefully selected according to their outcome (OS30 months (N = 6, i.e. short/long-OS. Highly stringent statistics included t-test, distance matrix with Spearman-ranked correlation, and iterative approaches. Unsupervised hierarchical analysis revealed that PDACs clustered according to their short/long-OS classification, while the feature selection algorithm RELIEF identified the top 4 discriminating miRNAs between the two groups. These miRNAs target more than 1500 transcripts, including 169 targeted by two or more. MiR-211 emerged as the best discriminating miRNA, with significantly higher expression in long- vs. short-OS patients. The expression of this miRNA was subsequently assessed by quantitative-PCR in an independent cohort of laser-microdissected PDACs from 60 resected patients treated with the same gemcitabine regimen. Patients with low miR-211 expression according to median value had a significantly shorter median OS (14.8, 95%CI = 13.1-16.5, vs. 25.7 months, 95%CI = 16.2-35.1, log-rank-P = 0.004. Multivariate analysis demonstrated that low miR-211 expression was an

  13. Utility of squamous cell carcinoma antigen, carcinoembryonic antigen, Cyfra 21-1 and neuron specific enolase in lung cancer diagnosis: a prospective study from China

    Institute of Scientific and Technical Information of China (English)

    SONG Wei-an; LIU Xi; TIAN Xiao-dong; WANG Wei; LIANG Chao-yang; ZHANG Tao; GUO Jun-tang; PENG Yang-hong; ZHOU Nai-kang

    2011-01-01

    Background Early detection and diagnosis is urgent for the sake of effective treatment strategy for lung cancer.However,a convenient,economical and relatively precise method is not available.We here report a prospective study to find the possible value of the combined use of four popular tumor markers in the early diagnosis of lung cancer among patients with suspicious nodules in the lung.Methods Six hundred and sixty inpatients with suspicious nodules in the lung were divided into a lung cancer group and a benign pulmonary tumor group according to post-operative histological examinations.Serum levels of four tumor markers including squamous cell carcinoma antigen (SCC),carcinoembryonic antigen (CEA),Cyfra 21-1 and neuron specific enolase (NSE) were assayed for each patient.Receiver operating characteristic (ROC) curves were constructed for each tumor marker.The power of lung cancer diagnosis of each tumor marker,as well as a combination of them were analyzed and compared.Results The serum levels (median,range) of SCC,CEA,Cyfra 21-1 and NSE were 0.44 (0.01-35.70) ng/ml,2.49(0.30-26.78) ng/ml,2.30 (0.82-73.33) ng/ml and 10.54 (0.10-56.41) ng/ml respectively in lung cancer group,and were 0.32 (0.01-0.90) ng/ml,1.60 (0.20-8.93) ng/ml,1.41 (0.72-4.82) ng/ml and 9.36 (6.56-24.24) ng/ml respectively in the benign pulmonary tumor group.The difference in each tumor marker between the two groups was significant (P <0.05).The ROCs of SCC,CEA,Cyfra 21-1 and NSE were 0.702 (95% CI,0.654-0.751),0.611 (95% CI,0.563-0.659),0.650(95% CI,0.601-0.700) and 0.598 (95% CI,0.542-0.654) respectively,indicating very low power of these four tumor markers.When a combination of SCC,CEA,Cyfra 21-1 and NSE were employed,the diagnosis power was strengthened.Conclusion SCC,CEA,Cyfra 21-1 and NSE are valuable in the early diagnosis of lung cancer among suspicious nodules in the lung,especially when they were assayed together for one patient.

  14. Assessing novel prognostic serum biomarkers in advanced pancreatic cancer: the role of CYFRA 21-1, serum amyloid A, haptoglobin, and 25-OH vitamin D3.

    Science.gov (United States)

    Haas, Michael; Kern, Christoph; Kruger, Stephan; Michl, Marlies; Modest, Dominik P; Giessen, Clemens; Schulz, Christoph; von Einem, Jobst C; Ormanns, Steffen; Laubender, Rüdiger P; Holdenrieder, Stefan; Heinemann, Volker; Boeck, Stefan

    2015-04-01

    The present prospective single-center study investigated the prognostic role of novel serum biomarkers in advanced pancreatic cancer (PC). Patients (pts) with locally advanced or metastatic PC treated with first-line palliative chemotherapy were included. Among others, the serum markers CYFRA 21-1, haptoglobin, serum-amyloid A (SAA), and 25-OH vitamin D3 were determined at baseline and categorized by pre-defined cut-offs [median values (MV), upper limits of normal (ULN), lower limits of normal (LLN), or the natural logarithm (ln)] and correlated with overall survival (OS). Among the 59 pts included, pre-treatment CYFRA 21-1 levels showed a strong correlation with OS independent of the applied cut-off (MV 4.9 ng/ml-14.2 vs. 4.2 months, HR 0.18, p = 0.001; ULN 3.3 ng/ml-14.2 vs. 4.4 months, HR 0.28, p = 0.003; [ln] CYFRA 21-1-HR 0.77, p = 0.013). Lower values of haptoglobin were additionally associated with an improvement in OS (categorized by LLN of 2.05 g/l-10.4 vs. 5.5 months, HR 0.46, p = 0.023; [ln] haptoglobin-HR 0.51, p = 0.036). Pts with baseline SAA values below the MV of 22 mg/l also had a prolonged OS (10.4 vs. 5.0 months, HR 0.47, p = 0.036). For 25-OH vitamin D3 levels, no significant correlation with OS was found. In multivariate analyses, pre-treatment CYFRA 21-1 levels (categorized by MV-HR 0.15, p = 0.032) as well as [ln] haptoglobin (HR 0.30, p = 0.006) retained their independent prognostic significance for OS. CYFRA 21-1, haptoglobin, and SAA might provide useful prognostic information in advanced PC. An external multicenter validation of these results is necessary. PMID:25472579

  15. 我国“211工程”大学高层领导群体特征的履历分析%Curriculum Vitae Analysis on the Leadership Characteristics in China’s“211 Project”Universities

    Institute of Scientific and Technical Information of China (English)

    高八民

    2015-01-01

    The article analyzed the group characteristics of 567 high-level leaders in 112 China’s“211 Pro-ject”universities based on their curriculum vitae. And the results show:(1)on demographic,the age of the senior leaders in the universities is about 55 years old,and most of them are male and Han nationality. It seems that the higher of the university level,the older of its leader. And there is still the“glass ceiling”phenomenon-the female leaders are difficult promoted in the universities,but no ethnic discrimination. (2)On academic,compared with the administrative leaders and the vice leaders,the party leaders and the principal leaders should have higher edu-cational background,professional qualifications and international level. And compared with the person who comes from other academic backgrounds,it seems that those who from science background have more opportunities to be a senior leader.(3)On working position,the higher of the university level,the richer working experiences that the senior leaders have. And the party leaders have more abundant working experience respect to the executive leaders. By the way,most of the principal leaders have the outside-system working experience and are from the external se-lection. But on the whole,internal promotion is still the main way for a leader.%以我国112所“211工程”大学的567名高层领导的履历资料为基础,对大学高层领导的群体特征进行实证分析,结果显示:(1)在人口统计学特征上,我国大学高层领导以55岁左右的汉族男性为主,越是高水平的大学,其高层领导越可能是年长者,女性难以晋升的“玻璃天花板”现象依然存在,但不存在民族歧视;(2)在学术特征上,行政领导相对于党委领导、正职领导相对于副职领导,无论是学历、职称还是国际化水平上都有着更高的要求,且理工科背景出身相比其他背景来说,担任高层领导的机会更大;(3)

  16. Correlation between Changes in Serum Level of CEA and CYFRA 21-1 and Objective Response of Chemotherapy%血清CEA、CYFRA21-1的变化与化疗客观疗效的相关性

    Institute of Scientific and Technical Information of China (English)

    穆新林; 高占成; 叶阮健

    2009-01-01

    背景与目的 血清肿瘤标志物浓度反映肿瘤的代谢或凋亡情况,化疗后肿瘤标志物的变化有可能反映化疗的客观疗效.研究目的在于评价化疗期间血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA 21-1)的变化对预测晚期NSCLC化疗疗效的价值.方法 回顾性分析42例晚期非小细胞肺癌患者化疗1周期后血清CEA、CYFRA 21-1的变化,并分析其与影像学评价的化疗客观疗效的相关性.结果 化疗2周期后,客观有效率为28.6%.化疗前,血清CEA、CYFRA 21-1水平在化疗有效组(objective response,OR)和无效组(no response,NR)间没有差别.化疗1周期后,CEA、CYFRA 21-1下降比例在OR和NR两组间有差异.用化疗后CEA、CYFRA 21-1下降比例预测化疗的客观疗效,CEA、CYFRA21-1 ROC曲线下面积分别为0.875和0.919.治疗后CEA下降比例为22%时,预测化疗客观疗效的敏感性为58.3%,特异性为97%;CYFRA 21-1下降比例为51%时,敏感性为83.3%.特异性为93.3%;以下降比例为界值,联合CEA和CYFRA21-1检测结果,可以将预测客观疗效的敏感性提高到91.7%,特异性为86.7%.结论 CEA、CYFRA 21-1化疗后下降比例可以用于评价晚期非小细胞肺癌化疗疗效,但其下降比例的界值仍需进一步研究.

  17. Up, down, strange and charm quark masses with N{sub f}=2+1+1 twisted mass lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Carrasco, N. [INFN, Sezione di Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); Deuzeman, A. [Albert Einstein Center for Fundamental Physics, Institute for Theoretical Physics, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Dimopoulos, P. [Centro Fermi – Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Compendio del Viminale, Piazza del Viminale 1, I-00184 Rome (Italy); Dipartimento di Fisica, Università di Roma “Tor Vergata”, Via della Ricerca Scientifica 1, I-00133 Rome (Italy); Frezzotti, R. [Dipartimento di Fisica, Università di Roma “Tor Vergata”, Via della Ricerca Scientifica 1, I-00133 Rome (Italy); INFN, Sezione di “Tor Vergata”, Via della Ricerca Scientifica 1, I-00133 Rome (Italy); Giménez, V. [Departament de Física Teòrica and IFIC, Univ. de València – CSIC, Dr. Moliner 50, E-46100 València (Spain); Herdoiza, G. [PRISMA Cluster of Excellence, Institut für Kernphysik, Johannes Gutenberg-Universität, D-55099 Mainz (Germany); Lami, P.; Lubicz, V. [Dipartimento di Matematica e Fisica, Università Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); INFN, Sezione di Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); Palao, D. [Goethe-Universität, Institut für Theoretische Physik, Max-von-Laue-Straße 1, D-60438 Frankfurt am Main (Germany); and others

    2014-10-15

    We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with N{sub f}=2+1+1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210–450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI′-MOM method. The results for the quark masses converted to the MS{sup ¯} scheme are: m{sub ud}(2 GeV)=3.70(17) MeV, m{sub s}(2 GeV)=99.6(4.3) MeV and m{sub c}(m{sub c})=1.348(46) GeV. We obtain also the quark mass ratios m{sub s}/m{sub ud}=26.66(32) and m{sub c}/m{sub s}=11.62(16). By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate m{sub u}/m{sub d}=0.470(56), leading to m{sub u}=2.36(24) MeV and m{sub d}=5.03(26) MeV.

  18. 肿瘤 M2-PK、CEA、SCC、NSE 和 CYFRA21-1在人肺癌诊断中的比较%Comparison of tumor M2-PK, CEA, SCC, NSE and CYFRA21-1 in diagnosis of lung cancer

    Institute of Scientific and Technical Information of China (English)

    魏枫华; 齐川; 李满元

    2014-01-01

    Objective:To compare differences of tumor M2-PK, CEA, SCC, NSE and CYFRA21-1 in diagnosis of lung canc-er. Methods:142 cases with newly diagnosed lung cancer was recruited in the study. M2-PK was detected by an ELISA method. Re-sults: Through comparing tumor markers of human lung cancer with different histologic types, it found that M2-PK had a higher sensi-tivity (57% ) than those of CEA (38% ) and CYFRA 21-1 (43% ). In non-small cell lung cancer (NSCLC), M2-PK (59% ), CEA (39% ) and CYFRA21-1 (56% ) were more sensitive than others. However, for small cell lung cancer, NSE was more sensitive than the other tumor markers. Conclusions: M2-PK can be a better marker for the diagnosis of lung cancer.%目的:为了比较 M2-PK、CEA、CYFRA21-1、NSE 和 SCC 在人肺癌诊断中的差异。方法:142例新诊断的肺癌患者被纳入本次研究,M2-PK 是用一个灵敏的 ELISA 试剂盒来检测的。结果:通过比较不同组织类型人肺癌的肿瘤标志物,发现 M2-PK 灵敏度(灵敏度57%)比 CEA(灵敏度38%)和 CYFRA 21-1(灵敏度43%)高。在非小细胞肺癌中 M2-PK(灵敏度59%),CEA(灵敏度39%),CYFRA21-1(灵敏度56%)的灵敏度普遍较高。对于小细胞肺癌来说,NSE 比其他标志物更敏感。结论:M2-PK 可以作为检测肺癌的标志物。

  19. 肿瘤 M2-PK、CEA、SCC、NSE 和 CYFRA21-1在人肺癌诊断中的比较%Comparison of tumor M2-PK, CEA, SCC, NSE and CYFRA21-1 in diagnosis of lung cancer

    Institute of Scientific and Technical Information of China (English)

    魏枫华; 齐川; 李满元

    2014-01-01

    目的:为了比较 M2-PK、CEA、CYFRA21-1、NSE 和 SCC 在人肺癌诊断中的差异。方法:142例新诊断的肺癌患者被纳入本次研究,M2-PK 是用一个灵敏的 ELISA 试剂盒来检测的。结果:通过比较不同组织类型人肺癌的肿瘤标志物,发现 M2-PK 灵敏度(灵敏度57%)比 CEA(灵敏度38%)和 CYFRA 21-1(灵敏度43%)高。在非小细胞肺癌中 M2-PK(灵敏度59%),CEA(灵敏度39%),CYFRA21-1(灵敏度56%)的灵敏度普遍较高。对于小细胞肺癌来说,NSE 比其他标志物更敏感。结论:M2-PK 可以作为检测肺癌的标志物。%Objective:To compare differences of tumor M2-PK, CEA, SCC, NSE and CYFRA21-1 in diagnosis of lung canc-er. Methods:142 cases with newly diagnosed lung cancer was recruited in the study. M2-PK was detected by an ELISA method. Re-sults: Through comparing tumor markers of human lung cancer with different histologic types, it found that M2-PK had a higher sensi-tivity (57% ) than those of CEA (38% ) and CYFRA 21-1 (43% ). In non-small cell lung cancer (NSCLC), M2-PK (59% ), CEA (39% ) and CYFRA21-1 (56% ) were more sensitive than others. However, for small cell lung cancer, NSE was more sensitive than the other tumor markers. Conclusions: M2-PK can be a better marker for the diagnosis of lung cancer.

  20. Correlation between cyfra 21-1 concentration in saliva and CK19 expression in tissues from oral squamous cell carcinoma patients%口腔鳞癌患者唾液cyfra 21-1含量与癌组织CK19表达的相关性研究

    Institute of Scientific and Technical Information of China (English)

    钟来平; 张志愿; 胡宇华; 王丽珍; 李江; 陈万涛; 张陈平

    2010-01-01

    目的:检测口腔鳞癌患者唾液中cyfra 21-1含量、组织中CK19蛋白质表达和基因转录水平,探讨其相互关系.方法:对30例口腔鳞癌患者和30例正常人的唾液采用ELISA法检测cyfra 21-1含量,其中6例口腔鳞癌患者的癌组织和癌旁组织分别采用免疫组织化学和实时定量RT-PCR法检测CK19蛋白质表达强度和CK19mRNA水平,采用SPSS10.0软件包进行统计学分析.结果:口腔鳞癌患者唾液cyfra 21-1含量为(85.95±78.00)μg/L,显著高于对照组的(42.27±40.84)μg/L;口腔鳞癌癌组织CK19蛋白质表达强度和CK19mRNA水平显著高于癌旁组织.CK19mRNA水平与CK19蛋白质表达强度呈显著正相关,癌组织CK19蛋白质与唾液cyfra 21-1含量也显著相关.结论:口腔鳞癌患者唾液cyfra 21-1含量和组织CK19蛋白表达及基因转录水平显著升高,组织CK19表达升高,对唾液cyfra 21-1含量的上升起着重要作用.

  1. The value of combined detection of serum SCCA,CYFRA21-1 and CEA in diagnosis of lung cancer%血清SCCA、CYFRA21-1、CEA联合检测在肺癌诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    王小芳; 罗玲

    2013-01-01

    目的 评价血清鳞状细胞癌抗原(SCCA)、细胞角蛋白片段21-1(CYFRA21-1)、癌胚抗原(CEA)联合检测在肺癌诊断中的价值.方法 选择重庆市肿瘤研究所2008年1~4月住院患者共63例,收集所有患者血清检测SCCA、CYFRA21-1及CEA.其中肺癌44例,肺部良性病变者19例,肺癌患者中小细胞肺癌5例、鳞癌17例、腺癌15例,未定型肺癌7例,所有肺癌患者均为病理确诊.结果 肺癌组SCCA、CYFRA21-1、CEA水平均高于肺部良性病变组(P<0.01),在不同病理类型中,3种指标升高的程度不等,SCCA 及CYFRA21-1水平在鳞癌组最高,CEA水平在腺癌组最高,与其他组比较差异有统计学意义(P<0.01).结论 血清SCCA、CYFRA21-1、CEA检测在肺癌的诊断、病理类型的推断中具有重要意义,而联合检测更有助于肺癌的诊断.%Objective To evaluate the clinical value of combined determination of tumor markers including serum squamous cell carcinoma antigen(SCCA) ,cytokeratin 19 fragment(CYFRA21-l) , carcino-embryonic antigen(CKA) in diagnosis of lung cancer. Methods 63 cases including 44 cases of lung cancer and 19 benign lesion were collected from inpatients registered in our hospital from January to April in 2008. The lung cancer were pathologically diagnosed including 5 cases of small cell lung cancer, 17 cases of squamous cell carcinoma ,15 cases of adenocarcinoma,and 7 undecided type lung cancer. All cases were bronchoalveolar lavaged and bronchoalveolar lavage fluid were collected to prepare for detect SCCA, CYFRA21-1, CEA. Results The levels of the 3 tumor markers measured in serum were higher in lung cancer group than those in benign lung disease group(P<0. 01). The tumor markers increased to different degrees among the patients in various pathological classifications. The levels of SCCA ,CYFRA21-1 measured in serum were higher in squamous cell carcinoma group, and the levels of CEA were higher in adenocarcinoma group(P< 0. 01). Conclusion The

  2. Statistical Analysis on the Published Papers about Animal Husbandry and Veterinary in Five 211 Agricultural Universities Based on WOS%基于WOS的畜牧兽医学科发文统计分析——以5所211农业院校为例

    Institute of Scientific and Technical Information of China (English)

    王芹

    2012-01-01

    Based on the WOS (Web of Science), the published papers about animal husbandry and veterinary of five 211 agricultural universities in the past ten years were statistically analyzed. A case study of Northwest A&F University was carried out to expose the research status and problems of China animal husbandry and veterinary disciplines.%基于WOS(Web of Science,全球获取学术信息的主要数据库),对我国5所211农业院校的畜牧兽医学科近10年的发文进行统计分析,并以西北农林科大学为例进行了详细分析,展现了我国畜牧兽医学科领域的科研现状与问题.

  3. Diagnostic performance of CD66c in lung adenocarcinoma-associated malignant pleural effusion: comparison with CEA, CA 19-9, and CYFRA 21-1.

    Science.gov (United States)

    Son, Seung-Myoung; Han, Hye-Suk; An, Jin Young; Choe, Kang Hyeon; Lee, Ki Man; Lee, Ki Hyeong; Kim, So-Seul; Lee, Yong-Moon; Lee, Ho-Chang; Song, Hyung Geun; Lee, Ok-Jun

    2015-02-01

    Various tumour markers have been evaluated in malignant pleural effusions, but not CD66c. This study evaluated the diagnostic ability of CD66c in lung adenocarcinoma-associated malignant pleural effusions (LA-MPEs) and compared it with other known tumour markers. Forty-seven cases of LA-MPE and 52 cases of benign pleural effusions were collected. The levels of CD66c, CEA, CA 19-9, and CYFRA 21-1 were measured by enzyme immunoassay. The expression of CD66c, CEA, and CA 19-9 in cell blocks was measured by immunocytochemistry. CEA had the best diagnostic values, with a sensitivity of 87.2% and specificity of 92.3%. Both CD66c and CA 19-9 showed the highest specificity of 98.1%, with sensitivities of 63.8% and 55.3%, respectively. CYFRA 21-1 had a sensitivity of 83.0% and specificity of 76.9%. CEA combined with CA 19-9 reached a sensitivity of 91.5% and a specificity of 98.1%. The sensitivities of immunocytochemical staining for CD66c, CEA, and CA 19-9 were 72.5%, 75%, and 40%, respectively. CD66c showed a diagnostic performance comparable to CYFRA 21-1 and CA 19-9 by enzyme immunoassay. Immunocytochemical study showed that CD66c and CEA were more sensitive than CA19-9. Both studies support CD66c as a potential tumour marker to differentiate LA-MPE from benign effusions. PMID:25551300

  4. Spatial analysis of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (Sea-Nine 211) concentrations and probabilistic risk to marine organisms in Hiroshima Bay, Japan

    International Nuclear Information System (INIS)

    We analyzed the spatial distribution of an antifouling biocide, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (Sea-Nine 211) in the surface water and sediments of Hiroshima Bay, Japan to determine the extent of contamination by this biocide. A quantitative estimate of the environmental concentration distribution (ECD) and species sensitivity distributions (SSDs) for marine organisms were derived by using a Bayesian statistical model to carry out a probabilistic ecological risk analysis, such as calculation of the expected potentially affected fraction (EPAF). The spatial distribution analysis supported the notion that Sea-Nine 211 is used mainly for treatment of ship hulls in Japan. The calculated EPAF suggests that approximately up to a maximum of 0.45% of marine species are influenced by the toxicity of Sea-Nine 211 in Hiroshima Bay. In addition, estimation of the ecological risk with a conventional risk quotient method indicated that the risk was a cause for concern in Hiroshima Bay. - Highlights: • Spatial distribution analysis exhibits the dynamics of Sea-Nine 211 in Hiroshima Bay. • Probabilistic ecological risk of the biocide was estimated with a Bayesian approach. • Approximately up to 0.45% of marine species were possibly influenced by the toxicity. • The risk analysis concludes that Sea-Nine 211 should be a priority for further work. - Spatial distribution of an antifouling biocide and quantification of its ecological risk were elucidated

  5. 细胞角蛋白21-1与转移生长因子-β1联合检测诊断良恶性腹水的意义

    Institute of Scientific and Technical Information of China (English)

    何坤; 沈流燕; 罗强

    2010-01-01

    目的 评价细胞角蛋白21-1(CYFRA21-1)与转移生长因子-β1(TGF-β1)联合检测诊断良恶性腹水的意义.方法 选取82例腹水患者,采用酶联免疫吸附试验检测其腹水中CYFRA21-1与TGF-β1水平.结果 肝癌组患者腹水中CYFRA 21-1明显高于结核性腹膜炎和弥漫性腹膜炎患者,差异有统计学意义(P<0.05);肝癌组患者腹水中TGF-β1明显高于结核性腹膜炎患者,差异有统计学意义(P<0.05).结论 CYFRA21-1与TGF-β1联合检测对诊断癌性腹水和结核性腹膜炎具有实际临床意义.

  6. RI/MOM renormalization constants (N_f=4) and the strong coupling constant (N_f=2+1+1) from twisted-mass QCD

    CERN Document Server

    Blossier, B; Brinet, M; De Soto, F; Du, X; Gravina, M; Liu, Z; Morenas, V; Pène, O; Petrov, K; Rodríguez-Quintero, J

    2011-01-01

    We study RI/MOM renormalization constants of bilinear quark operators for $N_f=4$ and the strong coupling constant for $N_f=2+1+1$ using Wilson twisted-mass fermions. We use the "egalitarian" method to remove H(4) hypercubic artifacts non-perturbatively, which enables us to study physical quantities in a wide range of momenta. We then apply OPE in studying the running behavior of $Z_q$ and $\\alpha_s$, from which we are able to extract the Landau gauge dimension-two gluon condensate $$ which is of phenomenological interest.

  7. Diagnostic value of Cyfra21-1, SCC and CEA for differentiation of early-stage NSCLC from benign lung disease

    OpenAIRE

    Chen, Feng; Wang, Xiu-Ying; Han, Xiao-Hong; Wang, Hai; Qi, Jun

    2015-01-01

    Non-small cell lung cancer (NSCLC), which account for the most of lung carcinoma, is sometimes difficult to differentiate from benign lung diseases presented with nodular shadow in imaging scan. There is a need to find another non-invasive way to diagnosis early-stage NSCLC. To examine the potential diagnostic value of SCC, CFYRA 21-1 and CEA for the differentiation of early-stage NCSCL from benign lung diseases, we analyzed serum levels of tumor markers in 278 patients, including 248 patient...

  8. Hadron-Hadron Interactions from $N_f=2+1+1$ Lattice QCD: isospin-2 $\\pi\\pi$ scattering length

    CERN Document Server

    Helmes, C; Knippschild, B; Liu, C; Liu, J; Liu, L; Urbach, C; Ueding, M; Wang, Z; Werner, M

    2015-01-01

    We present results for the $I=2$ $\\pi\\pi$ scattering length using $N_f=2+1+1$ twisted mass lattice QCD for three values of the lattice spacing and a range of pion mass values. Due to the use of Laplacian Heaviside smearing our statistical errors are reduced compared to previous lattice studies. A detailed investigation of systematic effects such as discretisation effects, volume effects, and pollution of excited and thermal states is performed. After extrapolation to the physical point using chiral perturbation theory at NLO we obtain $M_\\pi a_0=-0.0442(2)_\\mathrm{stat}(^{+4}_{-0})_\\mathrm{sys}$.

  9. 影像学征象结合血清PCT、CYFRA21-1对孤立性肺结节的评估%Evaluation of Solitary Pulmonary Nodule with Imaging Features and Serum PCT and CYFRA21-1

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    Objective To explore the correlation between dual-source computed tomography (DSCT) features of solitary pulmonary nodule (SPN) and the expression of serum Procalcitonin (PCT) and CYFRA21-1, and the benign and malignancy decision as well. Meth-ods A retrospective analysis was made to the clinical data of 30 patients with SPN surgically treated in our hospital from Jan., 2009 to Dec., 2011; all the patients received DSCT examination and serum PCT and CYFRA21-1 detection and the results were studied for the correlation analysis and SPN benign and malignancy evaluation. Results Chest DSCT showed out a high specificity, sensitivity and ac-curacy for clinical diagnosis of the benign lesions: hamartoma and pulmonary tuberculoma, and alveolar cell carcinoma as well (P0.05); PCT showed out a high specificity, sensitivity and accuracy for clinical diagnosis of pulmonary infection (P0.05);而PCT对肺部感染的诊断临床特异性、敏感性、准确度均较高(P <0.05);CYFRA21-1血清表达对恶性病变诊断的临床特异性、敏感性、准确度均较高(P <0.05)。结论 PCT 及 CYFRA21-1血清标本检测对胸部 DSCT 难以鉴别的肺部感染和恶性肿瘤具有一定的帮助,为SPN的诊断提供了新的依据。

  10. 血清CEA、NSE及CYFRA21-1联合检测对肺癌的诊断价值%Diagnostic Value of Combined Detection of Serum CEA,NSE and CYFRA 21-1 in Patients with Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    何雨洁; 郭思慧; 胡继青; 袁辉; 徐诚; 张成席

    2010-01-01

    为探讨血清CEA、NSE及CYFRA21-1对不同组织类型肺癌的诊断价值, 对95例肺癌患者(其中鳞癌38例,腺癌41例,小细胞肺癌16例)和45例肺部良性病变患者(对照组), 用电化学发光免疫分析法检测血清CEA、NSE及CYFRA 21-1.结果表明, CEA在腺癌中阳性率最高(52.2%), NSE在小细胞肺癌的阳性率为69.7%, CYFRA 21-1在鳞癌及腺癌的阳性率分别为57.3%、46.7%.三项联合检测在鳞癌、腺癌及小细胞肺癌中的阳性率分别为71.3%、89.9%及72.8%.CEA、NSE及CYFRA 21-1在不同的肺癌病理类型有不同的表达,单项标志物对肿瘤的诊断价值有限,而且某些良性疾病也可以升高.三项标志物联合检测可提高肺癌诊断的敏感性和特异性.

  11. Analysis in patients of the Hospital A.C. Camargo of two tumors markers: CA-72.4 and CYFRA-21.1; Analise em pacientes do Hospital A.C. Camargo de dois marcadores tumorais: CA-72.4 e CYFRA-21.1

    Energy Technology Data Exchange (ETDEWEB)

    Barbuto, Jose Alexandre Marzagao; Oda, Emilia Emiko; Oliveira, Ricardo Manoel de [Fundacao Antonio Prudente, Sao Paulo, SP (Brazil). Hospital A.C. Camargo

    1995-03-01

    The behavior of two tumor markers, CA-72.4 and CYFRA-19.9 was analysed in patients of the Hospital A.C. Camargo. The measurement of CA-272.4 serum levels was performed by an automated chemo luminescence assay in 49 patients and proved useful in the two groups analyzed, patients with esophageal tumors and with gastric tumors. In both cases, there was an increase in sensitivity when measurements of this marker was added to that of carcinoembryonic antigen (CEA) and of CA-19.9. The most sensitive associations were of CA-72.4 and CA-19.9 for esophageal tumors and of CA-72.4 and CEA for the gastric tumors. The maker CYFRA-21.1 was analyzed by a radioimmunoassay in 102 normal blood donors and in 20 patients with lung cancer. Among these, CYFRA-21.1 was altered in 55% of the cases. Therefore, CYFRA-21.1 could be considered, as the neuron-specific enolase (NSE), very useful tool for the follow-up lung cancer patients. (author) 6 refs., 3 figs., 3 tabs.

  12. CYFRA21-1、CEA、NSE和CA125联合检测在非小细胞肺癌中的诊断价值%The Diagnostic Value of Combined Detection of CYFRA21-1,CEA,NSE and CA125 in Non Small Cell Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    邢国燕; 赵树波

    2016-01-01

    Objective:To discuss the diagnostic value of combined detection of CYFRA21-1,CEA, NSE and CA125 in non small cell lung cancer.Method:92 cases of NSCLC and 95 cases of lung benign lesions from January 2010 to June 2015 in our hospital were selected as the research objects,92 cases of NSCLC were divided into 42 cases of lung squamous cell carcinoma group and 50 cases of lung adenocarcinoma group according to the different pathological types.The levels of CYFRA21-1, CEA, NSE and CA125 in all patients were measured by electrochemical luminescence method.Result:The CYFRA21-1,CEA,NSE and CA125 in NSCLC group were significantly higher than those in benign lung disease group,the differences were statistically significant (P<0.05).The sensitivity and specificity of CYFRA21-1 were respectively 71.40% and 89.10% in lung squamous cell carcinoma group,the sensitivity and specificity of CEA were respectively 60.00% and 84.30% in lung adenocarcinoma group.The sensitivity of CYFRA21-1 in the diagnosis of NSCLC was 46.53%,specificity was 85.26%.The sensitivity of CEA in the diagnosis of NSCLC was 42.58%,specificity was 81.05%.The sensitivity of NSE in the diagnosis of NSCLC was 57.43%,specificity was 76.85%.The sensitivity of CA125 in the diagnosis of NSCLC was 48.51%,specificity was 66.32%.Combined determination of the four parameters sensitivity was 93.26%,specificity was 98.25%.Conclusion:CYFRA21-1,CEA,CA125 and NSE have certain value for the early detection and diagnosis of NSCLC,and the combined detection of the four has obvious complementarity, which can significantly improve the diagnostic rate of NSCLC.%目的:探讨细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、糖类抗原125(CA125)联合检测在非小细胞肺癌(NSCLC)中的诊断价值。方法:选取2010年1月-2015年6月本院收治的NSCLC患者92例和肺部良性病变患者95例作为研究对象,92例NSCLC患者根据病理类

  13. 尿细胞角蛋白CYFRA 21-1浓度检测对膀胱移行细胞癌的诊断价值%The Diagnose Value of the CYFRA21-1 in Urine in Bladder Transitional Cell Carcinoma

    Institute of Scientific and Technical Information of China (English)

    周莉莉; 高云朝

    2008-01-01

    目的 探讨检测尿细胞角蛋白CYFRA 21-1在诊断膀胱移行细胞癌中的价值.方法 检测膀胱移行细胞癌患者与膀胱良性病变患者及健康对照组尿CYFRA 21-l的值,比较各组间的差异.结果 移行细胞组尿CYFRA21-1浓度显著高于良性病变组及健康对照组,差异有高度统计学意义(P0.05);在移行细胞癌组中转移患者与未转移患者比较,差异亦有高度统计学意义(P<0.01).结论 尿CYFRA 21-1检测对诊断膀胱癌及其转移有一定的临床价值.

  14. Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the {alpha}-emitting radionuclides {sup 212}Bi or {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Wesley, Jon N.; McGee, Edwin C.; Garmestani, Kayhan; Brechbiel, Martin W.; Yordanov, Alexander T.; Wu Chuanchu; Gansow, Otto A.; Eckelman, William C.; Bacher, John D.; Flynn, Michael; Goldman, Carolyn K.; MacLin, Melvin; Schwartz, Uwe P.; Jackson-White, Terri; Phillip, Celeste M.; Decker, Jean; Waldmann, Thomas A. E-mail: tawald@helix.nih.gov

    2004-04-01

    To exploit the fact that IL-2 receptors are expressed by T-cells responding to foreign antigens but not by resting T-cells, humanized anti-Tac (HAT) armed with alpha-emitting radionuclides {sup 212}Bi and {sup 211}At was evaluated in a cynomolgus cardiac allograft model. Control graft survival was 8.2{+-} 0.5 days compared with 14.0{+-}1.3 days (p<0.01) survival for monkeys treated with {sup 212}Bi labeled HAT and 26.7{+-}2.4 days survival (p<0.001 versus controls) with {sup 211}At labeled HAT. Thus, {sup 211}At labeled HAT may have application in organ transplantation and in treatment of IL-2 receptor expressing T-cell leukemia.

  15. Value of tumor markers in differential diagnosis of malignant hydrothorax%CEA、CYFRA 21-1对肺非小细胞性恶性胸腔积液诊断价值的研究

    Institute of Scientific and Technical Information of China (English)

    张益辉; 王泽球; 张庆文

    2007-01-01

    目的 观察胸水及血清CEA、CYFRA21-1测定值对非小细胞性恶性胸腔积液的诊断价值.方法 测定本院145例胸腔积液病人的血清及胸水CEA、CYFRA21-1,按良恶性分为两组,并行统计分析.结果 胸水及血清CEA、CYFRA21-1测定值,在两组之间有非常显著差异.结论 血及胸水肿瘤标记物测定可作为胸腔积液病人检测的一个常规项目,对恶性胸腔积液有较高的诊断价值.

  16. The diagnostic value for combination of 4 serum tumor markers CEA ,NSE, CYFRA21-1 and SCC-Ag in lung cancer%CEA、NSE、CYFRA21-1、SCC-Ag在肺癌诊断中的价值研究

    Institute of Scientific and Technical Information of China (English)

    叶雅丽; 闫李侠; 阮荣华

    2012-01-01

      Objective :To investigate the clinical diagnosis value in lung cancer to combine four serum tumor marker CEA ,NSE, CYFRA21-1 and SCC-Ag .Methods : To analyze retrospectively the diagnosis sensitivity of CYFRA21-1 ,CEA ,NSE and SCC in 115 cases with lung cancer,58 with being lung diseases and 90 healthy controls .Results : The serum tumor marker levels in the lung cancergroup were significantly higher than those in benign lung disease group and control group (P<0.01);These four TM combinations may be more sensitive in the diagnosis of lung cancer(P <0.05) .Conclusion : Combination of four serum tumor marker CEA ,NSE, CYFRA21-1 and SCC-Ag markers can increase the clinical diagnosis value in lung cancer .%  目的探讨血清肿瘤标志物癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、鳞状上皮细胞癌抗原(SCC-Ag)单独或联合检测对肺癌的诊断价值.方法测定115例肺癌患者、58例肺良性疾病患者及健康对照者90例四种血清肿瘤标志物的含量水平,并计算各项目阳性率.结果肺癌组4项肿瘤标志物水平显著高于健康组和肺良性疾病组及健康对照组(P<0.01);4项标志物联合检测对肺癌的敏感性和准确性均高于单项检测(P<0.05).结论 CEA、NSE 、CYFRA21-1、SCC-Ag 4项肿瘤标志物对肺癌的诊断具有较大的辅助诊断价值,联合检测可提高检出率.

  17. 血清CEA,CA125,NSE,CYFRA21-1联合检测对肺癌的诊断价值%Diagnostic Value of Combined Determination of Serum Tumor Markers (CEA, CA 125, NSE, CYFRA 21-1 ) Levels in Patients with Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    黄芳; 耿燕; 李婷婷; 张西英

    2008-01-01

    目的 探讨血清癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白片段21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)联合检测对肺癌的诊断价值.方法 采用电化学发光法对78例肺癌(其中鳞癌30例,腺癌28例,小细胞癌20例)、45例肺部良性病患者和36例健康人血清进行分析.结果 肺癌患者血清4种肿瘤标志物含量明显高于肺部良性疾病组(P<0.05)和健康对照组(P<0.01).肺癌组经病理分型后,NSE在小细胞肺癌中的水平明显高于其他类型的肺癌(P<0.05);CYFRA21-1的水平在鳞癌中升高尤为明显(P<0.05);CEA的水平在腺癌中显著升高(P<0.05).4种肿瘤标志物单项检测时,特异度较高(82.22%~95.56%),但敏感度不是很高(38.46%~56.41%).联合检测后,可提高肺癌的阳性检出率(64.10%).结论 CEA,CA125,NSE和CYFRA21-1对肺癌有一定的辅助诊断价值,且CEA,NSE和CYFRA21-1对不同组织类型肺癌均有一定诊断价值,联合检测可提高对肺癌的阳性诊断.

  18. Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude mice

    DEFF Research Database (Denmark)

    Back, T.; Haraldsson, B.; Hultborn, R;

    2009-01-01

    manifested late. Examination of the kidney sections showed histologic changes that were overall subdued. Following alpha-RIT with (211)At-MX35-F(ab')(2) at levels close to the dose limit of severe myelotoxicity, the effects found on renal function were relatively small, with only minor to moderate reductions......Besides bone marrow, the kidneys are often dose-limiting organs in internal radiotherapy. The effects of high-linear energy transfer (LET) radiation on the kidneys after alpha-radioimmunotherapy (alpha-RIT) with the alpha-particle emitter, (211)At, were studied in nude mice by serial measurements...... and animals bearing subcutaneous xenografts of the human ovarian cancer cell line, OVCAR-3, were used. The animals received approximately 0.4, 0.8, or 1.2 MBq in one, two, or three fractions. The mean absorbed doses to the kidneys ranged from 1.5 to 15 Gy. The renal function was studied by serial GFR...

  19. Ring-widths of the above tree-line shrub Rhododendron reveal the change of minimum winter temperature over the past 211 years in Southwestern China

    Science.gov (United States)

    Bi, Yingfeng; Xu, Jianchu; Yang, Jinchao; Li, Zongshan; Gebrekirstos, Aster; Liang, Eryuan; Zhang, Shibao; Yang, Yang; Yang, Yongping; Yang, Xuefei

    2016-08-01

    Changes in minimum winter temperature (MWT) and their potential effects on plant growth and development have been gaining increased scientific attention. To better understand these changes across long temporal scales, the present study used dendroclimatological techniques to assess variations in MWT in Southwestern China. Using data from Rhododendron species distributed in areas above the tree-line, a regional composite chronology was generated for a 341-year period. Based on the significant negative correlation between MWT values and ring-width, the most reliable parts of this chronological data were then used to reconstruct MWT values for the past 211 years. This reconstructed MWT series showed decadal to multi-decadal fluctuations. Three distinct cold periods prevailed during 1823-1858, 1882-1891 and 1922-1965, while four warm intervals occurred in 1800-1822, 1858-1881, 1892-1921 and 1966-2011. Our reconstructed MWT reveals a warming trend over the most recent eight decades, which is in agreement with instrumental observations. However, the MWT values and rate of warming over the past seven decades did not exceed those found in the reconstructed temperature data for the past 211 years. Spatial correlations reveal that the MWT in Southwest China is strongly associated with regional temperatures in the Eastern and Central Himalaya, Northern China, and the Indian Peninsula. Larger scale climate oscillations of the Western Pacific and Northern Indian Ocean as well as the North Atlantic Oscillation probably influenced the region's temperature in the past.

  20. The kinetic temperature of a molecular cloud at redshift 0.9: Ammonia in the gravitational lens PKS1830-211

    CERN Document Server

    Henkel, C; Menten, K M; Ott, J

    2008-01-01

    Using the Green Bank Telescope (GBT), we have detected the (J,K) = (1,1) to (10,10) ammonia inversion lines, up to 1030 K above the ground state, in a face-on spiral galaxy viewed against the radio continuum of the lensed background source PKS 1830-211. The ammonia absorption lines, seen at redshift 0.886, appear to be optically thin with absolute peak flux densities up to 2.5 percent of the total continuum of the background source. Measured intensities are consistent with a kinetic temperature of 80 K for 80-90 percent of the ammonia column. The remaining gas is warmer, reaching at least 600 K. Column density and fractional abundance are of order (5-10) x 10^14 cm^-2 and (1.5-3.0) x 10^-8. Similarities with a hot ammonia absorption component observed toward the Sgr B2 region close to the Galactic center may suggest that the Sgr B2 component also originates from warm diffuse low-density molecular gas. The warm ammonia column observed toward PKS 1830-211 is unique in the sense that it originates in a spiral ar...

  1. Final Report for research grant entitled "Development of Reagents for Application of At-211 and Bi-213 to Targeted Radiotherapy of Cancer"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant was a one-year extension of another grant with the same title (DE-FG03-98ER62572). The objective of the studies was to continue in vivo evaluation of reagents to determine which changes in structure were most favorable for in vivo use. The focus of our studies was development and optimization of reagents for pretargeting alpha-emitting radionuclides At-211 or Bi-213 to cancer cells. Testing of the reagents was conducted in vitro and in animal model systems. During the funding period, all three specific aims set out in the proposed studies were worked on, and some additional studies directed at development of a method for direct labeling of proteins with At-211 were investigated. We evaluated reagents in two different approaches in 'two step' pretargeting protocols. These approaches are: (1) delivery of the radionuclide on recombinant streptavidin to bind with pretargeted biotinylated monoclonal antibody (mAb), and alternatively, (2) delivery of the radionuclide on a biotin derivative to bind with pretargeted antibody-streptavidin conjugates. The two approaches were investigated as it was unclear which will be superior for the short half-lived alpha-emitting radionuclides.

  2. Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1

    Science.gov (United States)

    LeMaire, Scott A; McDonald, Merry-Lynn N; Guo, Dong-chuan; Russell, Ludivine; Miller, Charles C; Johnson, Ralph J; Bekheirnia, Mir Reza; Franco, Luis M; Nguyen, Mary; Pyeritz, Reed E; Bavaria, Joseph E; Devereux, Richard; Maslen, Cheryl; Holmes, Kathryn W; Eagle, Kim; Body, Simon C; Seidman, Christine; Seidman, J G; Isselbacher, Eric M; Bray, Molly; Coselli, Joseph S; Estrera, Anthony L; Safi, Hazim J; Belmont, John W; Leal, Suzanne M; Milewicz, Dianna M

    2011-01-01

    Although thoracic aortic aneurysms and dissections (TAAD) can be inherited as a single-gene disorder, the genetic predisposition in the majority of affected people is poorly understood. In a multistage genome-wide association study (GWAS), we compared 765 individuals who had sporadic TAAD (STAAD) with 874 controls and identified common SNPs at a 15q21.1 locus that were associated with STAAD, with odds ratios of 1.6–1.8 that achieved genome-wide significance. We followed up 107 SNPs associated with STAAD with P < 1 × 10−5 in the region, in two separate STAAD cohorts. The associated SNPs fall into a large region of linkage disequilibrium encompassing FBN1, which encodes fibrillin-1. FBN1 mutations cause Marfan syndrome, whose major cardiovascular complication is TAAD. This study shows that common genetic variants at 15q21.1 that probably act via FBN1 are associated with STAAD, suggesting a common pathogenesis of aortic disease in Marfan syndrome and STAAD. PMID:21909107

  3. Two novel epistatic mutations (E1:K211E and E2:V264A) in structural proteins of Chikungunya virus enhance fitness in Aedes aegypti.

    Science.gov (United States)

    Agarwal, Ankita; Sharma, Ajay Kumar; Sukumaran, D; Parida, Manmohan; Dash, Paban Kumar

    2016-10-01

    Expansion of CHIKV outbreaks with appearance of novel mutations are reported from many parts of the world. Two novel mutations viz. E1:K211E and E2:V264A in background of E1:226A are recently identified from Aedes aegypti dominated areas of India. In this study, the role of these mutations in modulation of infectivity, dissemination and transmission by two different Aedes species was studied. Mutations were sequentially constructed in CHIKV genome and female Ae. aegypti and Aedes albopictus mosquitoes were orally infected with eight different CHIKV mutants. Double mutant virus containing E1:K211E and E2:V264A mutations in background of E1:226A revealed remarkably higher fitness for Ae. aegypti, as indicated by significant increase in virus infectivity (13 fold), dissemination (15 fold) and transmission (62 fold) compared to parental E1:226A virus. These results indicate that adaptive mutations in CHIKV are leading to efficient CHIKV circulation in Ae. aegypti endemic areas, contributing and sustaining the major CHIKV outbreaks. PMID:27423270

  4. K^0-\\bar{K}^0 mixing in the Standard Model from Nf=2+1+1 Twisted Mass Lattice QCD

    CERN Document Server

    Carrasco, N; Dimopoulos, P; Frezzotti, R; Palao, D; Rossi, G C; Lubicz, V; Papinutto, M; Sanfilippo, F; Simula, S

    2011-01-01

    We present preliminary results at {\\beta} = 1.95 (a = 0.077 fm) on the first unquenched N_f=2+1+1 lattice computation of the B_K parameter which controls the neutral kaon oscillations in the Standard Model. Using N_f=2+1+1 maximally twisted sea quarks and Osterwalder-Seiler valence quarks we achieve O(a) improvement and a continuum-like renormalization pattern for the four-fermion operator. Our results are extrapolated/interpolated to the physical light/strange quark mass but not yet to the continuum limit. The computation of the relevant renormalization constants is performed non perturbatively in the RI'-MOM scheme using dedicated simulations with N_f=4 degenerate sea quark flavours produced by the ETM collaboration. We get B_K^{RGI} (a = 0.077) = 0.747(18), which when compared to our previous unquenched N_f=2 determination and most of the existing results, suggests a rather weak B_K^{RGI} dependence on the number of dynamical flavours. We are at the moment analysing lattice data at two additional {\\beta} v...

  5. 联合检测血清CEA、CYFRA21-1、NSE在肺癌诊断、分期、分型中的意义%Clinical Values of Combined Serum CEA,CYFRA21-1 and NSE Detection in Diagnosis,Staging and Predicting Pathologic Typing of Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    徐恩赐; 王利利; 周菊英

    2012-01-01

    目的 探讨血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)在肺癌诊断、临床分期以及病理分型中的作用.方法 采用化学发光法、放射免疫分析法和酶联免疫吸附法分别检测114 例肺癌患者和89例肺部良性疾病患者血清CEA、CYFRA21-1、NSE水平.结果 肺癌组血清CEA、CYFRA21-1、NSE含量明显高于肺良性疾病组(P<0.05);CEA、CYFRA21-1及NSE诊断肺癌的ROC曲线下面积分别是0.60、0.85、0.82;联合检测对肺癌诊断的灵敏度明显高于任何单一检测(P<0.05);Ⅰ+Ⅱ期肺癌组血清CEA含量明显高于肺良性疾病组(P<0.05);CEA 在腺癌组含量明显高于鳞癌组(P<0.05);NSE在小细胞肺癌组含量明显高于鳞癌组和腺癌组(P<0.05);血清CEA在Ⅰ、Ⅱ、Ⅲ期非小细胞肺癌组含量明显低于Ⅳ期(P<0.05);CYFRA21-1在Ⅰ、Ⅱ期非小细胞肺癌组含量明显低于Ⅲ、Ⅳ期(P<0.05).结论 CEA对肺癌的早期诊断有一定意义;血清CEA对腺癌的灵敏度最佳,NSE对小细胞肺癌的灵敏度最佳;早期肺癌血清CEA、CYFRA21-1水平明显低于晚期肺癌;三种肿瘤标志物联合检测可明显提高肺癌诊断的敏感性,对肺癌的临床诊断、病理分型、临床分期具有重要的临床意义.%Objective To evaluate the value of combined serum carcinoembryonic antigen(CEA),cytokeratin fragment 19(CYFRA21-1) and neuron-specific enolase(NSE) detection for diagnosis,staging and predicting of pathologic types in patients with pulmonary carcinoma.Methods The levels of CEA,CYFRA21-1 and NSE were measured in 114 patients with pulmonary carcinoma and 89 patients with pulmonary benign lesion,using chemoluminescence,RIA and ELISA methods respectively.Results The concentrations of CEA,CYFRA21-1 and NSE in the cancer patients group were obviously higher than those in benign lung diseases group(P < 0.05). In single index the ROC area of serum CEA,CYFRA21-1 and NSE was 0

  6. CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer%Cyfra21-1对进展期非小细胞肺癌一线化疗疗效的早期预测作用

    Institute of Scientific and Technical Information of China (English)

    Kashif Iqbal; Yuan Chen; Mengxian Zhang; Qian Chu

    2007-01-01

    Objective:In an era of ever evolving,promising new therapies for advanced non small celllung cancer(NSCLC),early predictors of response to therapy.are needed.We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response.Methods:29 consecutive.previously untreated.patients of advanced non small cell lung cancer,with measurable disease On CT scan were evaluated.All patients were treated with conventional systemic chemotherapy,although the choice of chemotherapy was left to the discretion of the treating physicians.Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy.CYFRA 21-1 was measured with an electrochemlluminescense immunoassay on an automatic analyzer (Elecsys 2000;Roche Diagnostics).Response was evaluated using Response evaluation criteria in solid tumors (RECIST)criteria.Result:10 patients had partial response,9 patients had stable disease and 9 had progressive disease.None of the patients had complete response.21/29(72%)patients had an elevated baseline value of CYFRA 21-1.62%patients(18/29)had a decrease in CYFRA21-1 after 1 cycle of chemotherapy.The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not.The average reduction was statistically significant(P=0.002;95%CI,from 0.8369 to 3.49464;t test).8 out of 10(80%)patients with partial response had a reduction in their 2nd reading of.CYFRA (P=0.019:95%CI,from 0.81965 to 7.20035;t test)which was significant.We also observed that 6/9 (66%)patients whose disease remains stable also had a decrease in their subsequent reading(P=0.0106;95%CI.from-0.44942 to 3.82720;t test),though it was not significant statistically.Although 5 out of 9(55%)patients,who had an increase in their CYFRA 21-1 level,had progressive disease,but it was not statistically significant(P=0.537;95%CI,from-1.20021 to 2.13354;t test).14 out of

  7. Prognostic value of CYFRA 21-1 and CEA in patients with undifferentiated nasopharyngeal carcinoma before and after radiotherapy%鼻咽未分化癌患者放疗前后血清人细胞角蛋白21-1片段和癌胚抗原水平与预后的关系

    Institute of Scientific and Technical Information of China (English)

    朱婉琦; 孙新东; 谢鹏; 孔莉; 于金明

    2011-01-01

    Objective The purpose of this study was to evaluate the potential of CYFRA 21-1 (CYFRA) and CEA as a prognostic marker in patients with undifferentiated nasopharyngeal carcinoma ( NPC). Methods From March 2004 to February 2008, 62 patients with newly diagnosed, undifferentiated NPC were treated in our department. Their clinocopathological data were analyzed retrospectively. All patients received intensity-modulated radiotherapy using 6 MV X-rays, and serum CYFRA and CEA before and after radiotherapy were assayed. The association among the long-term follow-up results and age, sex, smoke, TNM stage, chemotherapy, CEA, CYFRA and the changes in any direction of serum CYFRA and CEA were determined. Results Patients with low pre-RT level ( ≤ 2. 49μg/L) of CYFRA had a significantly better overall survival ( OS) than patients with high level ( > 2. 49 μg/L,OR = 8. 555, P = 0.029). N classification and T classification were positively associated with the prediction of progression free survival ( OR = 4. 054, P = 0. 001; OR = 3. 873, P = 0. 001 ). But there was no significant association between the rest predictors (age, sex, CEA, post-RT CYFRA, chemotherapy and a radiation-induced decrease in serum markers) and the survival or recurrence rate by multivariate analysis. Conclusions The results of the present study show that pre-RT serum CYFRA level is a valuable factor for predicting long-term survival in patients with undifferentiated nasopharyngeal carcinoma. More aggressive treatment may be given to those patients with a high serum CYFRA level.%目的 研究鼻咽未分化癌患者放疗前后血清人细胞角蛋白21-1片段(CFRA21-1)和癌胚抗原(CEA)水平与预后的关系.方法 回顾性分析2004年5月至2008年2月月随访资料完整、并经病理学确诊为无远处转移的62例鼻咽未分化癌患者的临床资料.所有患者均采用6MV X线调强放疗,分析放疗前后CYFBA21-1及CEA水平与患者预后的关系.结果 放疗前CYFRA21-1

  8. Diagnostic Value of CYFRA 21-1, CEA, CA 19-9, CA 15-3,and CA 125 Assays in Pleural Effusions: Analysis of 116 Cases and Review of the Literature%CYFRA 21-1、CEA、CA 19-9,CA 15-3和CA 125在胸水中的诊断价值:116例分析及文献复习

    Institute of Scientific and Technical Information of China (English)

    侯著法

    2007-01-01

    目的 评估CYFRA 21-1、CEA、CA 19-9,CA 15-3和CA 125在胸水中的诊断价值.方法 收集116例患者胸水,测定CYFRA 21-1、CEA、CA 19-9,CA 15-3和CA 125在其胸水中的含量;在美国MEDLINE系统中检索近15年相关文献.结果 所有肿瘤标记物在恶性胸水中的含量均高于良性胸水.CEA的准确度最高,达85.3%;CA 15-3、CYFRA 21-1和CA19-9的准确度相似,分别为71.5%,72.4%,71.5%;CA125准确度最低,仅40.5%.联合检测其准确度不高于单一指标CEA.Logistic回归分析显示对恶性胸水的预测最有统计学意义的指标是CA 15-和CYFRA 21-1.文献复习显示CEA,CA 15-3和CYFRA 21-1诊断价值最佳.结论 胸水CEA检测具有最高的准确度,其他肿瘤标记物,特别是CA 15-3和CYFRA 21-1可作为备选标记物.

  9. 肺癌患者血清中CK19-2G2和Cyfra21-1的测定及其对肺癌的诊断价值%Detection of serum CK19-2G2 and Cyfra21-1 protein and comparison of their diagnostic value for lung cancer

    Institute of Scientific and Technical Information of China (English)

    高佳; 王海; 齐军

    2008-01-01

    Objective To evaluate and compare the value of serum CK19-2G2 and Cyfra21-1 in diagnosis of lung cancer. Methods The serum concentration of CK19-2G2 and Cyfra21-1 was detected in 104 patients with lung cancer, 71 with benign lung diseases and 105 healthy volunteers. The value of the two parameters in the diagnosis of lung cancer was evaluated with ROC curve analysis. The mean level of CK19-2G2 in the three groups was compared with that of Cyfra21-1 by Mann-Whitney U test, and the correlation between these two parameters was calculated using Pearson coefficient correlation test. Results The mean serum CK19-2G2 concentration in the lung cancer group was 2.87 mU/ml, significantly higher than that in the group with benign lung diseases ( 1.02 mU/ml) and healthy volunteer group ( 0. 01 mU/ml) ( P = 0.000). The serum concentration of CK19-2G2 was positively correlated with that of Cyfra21-1, with a Pearson coefficient correlation of 0. 543. Furthermore, the mean serum CK19-2G2 level in squamous cell carcinoma group (8.35 mU/ml) was significantly higher than that in the other pathologic groups (P < 0.05). Conclusion CK19-2G2, with a higher specificity, may be a better tumor marker than CK19-2G2 in respect of specificity for non-small cell lung cancer (NSCLC), especially for squamous lung carcinoma, and deserves further study.%目的 测定肺癌患者血清中细胞角蛋白19(CK19)降解片段CK19-2G2的浓度,并评价其对肺癌的诊断价值.方法 采用CK19-2G2和Cyfr21-1的检测试剂盒,分别检测104例肺癌患者、7l例肺部炎症患者和105例健康体检者的血清标本,采用Pearson相关分析判断二者的相关性.运用受试者工作特性曲线(ROC)分析CKl9-2G2和Cyfra21-1的检测效能,并确定CK19-2G2诊断肺癌的临界值.比较CK19-2G2和Cyfra21-1诊断肺癌的灵敏度和准确率.结果 肺癌组、肺部炎症组和健康对照组血清CK19-2G2的中位浓度分别为2.87、1.02和0.01 mU/ml,肺癌组显著高于肺部炎

  10. 外周血Cyfra21-1、NSE和Ferritin联合检测对肺癌的诊断价值%Significance of Combined Detection of Serum Cyfra21-1 and NSE and Ferritin in Diagnosis of Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    吴兴平; 陈浩; 刘晓华; 曾秋耀; 戴淑琴

    2010-01-01

    目的 评价外周血细胞角蛋白19片段(Cyfra21-1)、神经元特异性烯醇化酶(NSE)和铁蛋白(Ferritin)联合检测对肺癌的诊断价值.方法 采用电化学发光免疫分析法测定168例肺癌患者、60例良性肺部疾病患者和50例健康体检者外周血的Cyfra21-1、NSE和Ferritin的水平.采用t检验和x2检验进行数据统计分析.结果 肺癌组Cyfra21-1、NSE、Ferritin的水平及阳性率[分别为(15.5±10.1)ng/ml与70.2%,(39.6±13.1)ng/ml与39.9%,(1323.5±861.4)ng/ml与64.9%]明显高于良性肺部疾病组[分别为(9.4±5.6)ng/ml与25.0%,(23.6±8.2)ng/ml与18.3%,(642.4±234.6)ng/ml与34.7%]和健康对照组[分别为(5.9±1.2)ng/ml与10.0%.(18.3±1.8)ng/ml与10.0%,(544.6±135.4)ng/ml与16..结论 %](P<0.01).随着临床分期逐渐升高,cyfra21-1、NSE、Ferritin的阳性率和水平也有不同程度升高.就组织类型而言,Cyfra21-1检测阳性率和表达水平以鳞癌较高.NSE的阳性率和表达水平以小细胞癌最高,而Ferritin的阳性率和表达水平则差异不显著.三项联合检测灵敏度达91.1%,与二项或单项比较差异有统计学意义(P<0.05).结论 外周血Cyfra21-1、NSE和Ferritin联合检测可提高肺癌检出率及对肺癌组织类型鉴别诊断具有重要临床意义.

  11. 玻璃体腔注射大麻素 HU-211治疗鼠青光眼视神经损伤的研究%Clinical study on intravitreal injection of cannabinoid HU - 211 for optic nerve damage in glaucoma rats

    Institute of Scientific and Technical Information of China (English)

    刘慧峰; 何媛; 贾俊; 姬明利; 席进伟

    2014-01-01

    目的:评价玻璃体腔内注射大麻素 HU-211对大鼠青光眼模型视神经的保护作用,为青光眼视神经损伤治疗提供实验依据。  方法:采用电凝巩膜表面静脉法制作大鼠青光眼模型18眼,随机分为3组:A 组分别隔日一次玻璃体腔注射1mg/0.1mL大麻素 HU-211,B 组隔日一次玻璃体腔注射0.1mL 生理盐水,C 组为高眼压组。随机选6只对侧眼为空白对照组,每日观察眼压变化情况,用药4wk 后处死大鼠,视网膜冰冻切片,HE 染色通过视网膜神经元的密度变化评估大鼠慢性高眼压模型视网膜神经元的损伤程度。  结果: B 组的凋亡程度及 RGC 的损伤程度明显高于 A组,差异有统计学意义( P0.05)。  结论:玻璃体腔注射大麻素(HU-211)对大鼠青光眼模型视神经视网膜有明显的保护作用。%To evaluate the protective effects of intravitreal injection of cannabinoid HU - 211 for optic nerve in glaucoma rats, providing the experimental evidence in the treatment of glaucoma optic nerve injury. ●METHODS: Glaucoma rats (18 eyes) were modeled by electric coagulation sclera surface vein and randomized into 3 groups, group A received intravitreal injection of 1mg/ 0. 1mL cannabinoid HU - 211 every other day respectively; group B was given intravitreal injection of 0. 1mL water every other day, group C was high intraocular pressure (lOP) group, 6 eyes were randomly selected for blank control group ( group D). lOP was observed every day. The rats were sacrificed after treatment 4wk, froze retina section, HE stain. The density fluctuation of retinal ganglion cell ( RGC ) neurons assessment the optic nerve of rat model with chronic high lOP glaucoma were measured. ●RESULTS: The apoptosis and damage degree of RGC in group B was obviously higher than that in group A, with statistically significant difference (P0. 05). ●CONCLUSlON: lntravitreal injection of cannabinoid HU-211 shows obvious protective effect

  12. Clinical significance of CYFRA21-1 and CEA in the early prognosis of patients with locally advanced non-small cell lung cancer%CYFRA21-1和CEA对局部晚期非小细胞肺癌患者早期预后的意义

    Institute of Scientific and Technical Information of China (English)

    张丽娜; 么建立; 郝殿晋; 李洪臣; 王术艺; 张庆波

    2013-01-01

    Objective: To investigate the value of evaluation indicators of carcinoembryonic antigen (CEA) and cy-tokeratin 19 fragment( CYFRA21 - 1) as short - term efficacy in patients with advanced non - small cell lung cancer (NSCLC). Methods: The level of serum CEA and CYFRA21 - 1 were detected by electrochemoluminescence immu-noassay in 85 patients with locally advanced non - small cell lung cancer. All statistical analyses were done with software of SPSS14.0. Results:The level of CYFRA21 - 1 and CEA was associated with the therapeutic effect. The level of CEA and CYFRA21 - 1 of patients achieving partial remission (PR) or complete remission ( CR) after treatment were decreased significantly; On the contrary, the level of CEA and CYFRA21 - 1 of patients achieving SD or PD were basically stable or increased. In a multivariate analysis , the level of CEA and CYFRA21 - 1 after one cycle of chemotherapy were confirmed as independent prognostic factors for therapeutic effect. Conclusion; The level of CY-FRA21 - 1 and CEA are associated with the therapeutic effect. Patients may get better prognosis with the decreasing of serum tumor marker level. The level of CEA and CYFRA21 - 1 after one cycle of chemotherapy are confirmed as independent prognostic factors for therapeutic effect.%目的:研究癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA21-1)作为晚期非小细胞肺癌(NSCLC)短期疗效评价指标的价值.方法:采用电化学发光法测定85例初治的局部晚期NSCLC患者化疗前后血清中CEA、CYFRA21-1的水平,所有统计应用SPSS14.0统计软件进行分析.结果:化疗前CEA、CYFRA21-1在治疗有效组(CR+ PR)和无效组(SD+ PD)的分布无显著性差异.二者的水平在治疗有效组的化疗后明显低于化疗前,比较有显著性差异;在无效组化疗后的表达水平高于化疗前,但比较无显著性差异.多因素分析显示化疗前低水平的血清CEA、CYFRA21-1是近期疗效的保护性因素,化疗

  13. Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

    NARCIS (Netherlands)

    M. Bousquet (Marina); C. Quelen (Cathy); R. Rosati (Roberto); V.M.D. Mas; R.L. Starza (Roberta); C. Bastard (Christian); E. Lippert (Eric); P. Talmant (Pascaline); M. Lafage-Pochitaloff (Marina); D. Leroux (Dominique); C. Gervais (Carine); F. Viguié (Franck); J.L. Lai; C. Terre (Christine); H.B. Beverloo (Berna); C. Sambani (Costantina); A. Hagemeijer (Anne); P. Marynen (Peter); G. Delsol (Georges); N. Dastugue (Nicole); C. Mecucci (Cristina); P. Brousset (Pierre)

    2008-01-01

    textabstractMost chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we ha

  14. The bicyclo[2.1.1]hexan-2-one system: a new probe for the experimental and computational study of electronic effects in pi-facial selectivity in nucleophilic additions

    OpenAIRE

    Mehta, Goverdhan; Singh, Robindro S; Gagliardini, Vanessa; Priyakumar, Deva U; Sastry, Narahari G.

    2001-01-01

    The remotely substituted 5-exo-bicyclo[2.1.1]hexan-2-one system is introduced as a new probe to study long range electronic effects on pi-face selectivity during hydride reduction and a systematic computational study demonstrates good predictability at the semi-empirical level.

  15. HO-1、CYFRA21-1对食管癌的诊断价值以及对放化疗疗效的评估

    Institute of Scientific and Technical Information of China (English)

    黄金娜; 王献伟; 王爱玲

    2014-01-01

    目的:通过联检血红素加氧酶-1(HO-1)及细胞角蛋白19片段( CYFRA21-1)的含量,观察其对食管癌患者的临床诊断价值以及对放化疗疗效预后价值。方法124例食管癌患者、28例正常人血清样品用酶免疫分析系统测定HO-1及CYFRA21-1的含量。结果与正常人血清相比,食管癌患者血清HO-1及CYFRA21-1含量明显升高,两项标志物阳性检出率分别为29@.0%和39.5%,两者联检阳性率为51.6%。并且随着食管癌疾病进程的增加, HO-1以及CYFRA 21-1的阳性率随之增高。食管癌患者血清HO-1、CYFRA21-1含量在放化疗后与治疗前相比差异有统计学意义( P <0.05)。结论 HO-1与CYFRA21-1测定对食管癌患者疾病进展诊断具有一定的临床价值,两者联合检测不仅可提高食管癌鳞癌的阳性诊断率,对食管癌患者的放化疗疗效、预后也具有重要价值。 CYFRA21-1可能是一个明确的独立预测因子针对食管癌放疗敏感性。

  16. 联合检测血清Cyfra21-1、CK19-2G2在非小细胞肺癌患者中的诊断

    Institute of Scientific and Technical Information of China (English)

    廖长征; 徐文莉; 魏晟潇; 许瑞环; 刘紫菱; 罗艺

    2014-01-01

    目的:探讨联合检测血清Cyfra 21-1、CK19-2G2在非小细胞肺癌患者中的诊断。方法:采用化学发光免疫法检测92例非小细胞肺癌患者、83例肺部良性疾病患者和90例健康体检者血清Cyfra 21-1、CK19-2G2的浓度,并判断两者的相关性。比较单独与联合检测Cyfra21-1、CK19-2G2对于诊断非小细胞肺癌的灵敏度和特异性。结果:非小细胞肺癌组血清Cyfra 21-1、CK19-2G2水平显著高于肺部良性疾病组和健康对照组(P〈0.01);非小细胞肺癌患者血清Cyfra 21-1与CK19-2G2水平呈正相关性(P〈0.05)。两者联合诊断非小细胞肺癌的灵敏度为82.7%、特异性为78%。结论:Cyfra 21-1、CK19-2G2是有效的诊断非小细胞肺癌的肿瘤标志物。血清Cyfra 21-1、CK19-2G2水平在非小细胞肺癌的诊断中有临床应用价值,两者联合检测的灵敏度和特异性高。

  17. Safety experience with bosentan in 146 children 2-11 years old with pulmonary arterial hypertension: results from the European Postmarketing Surveillance program

    DEFF Research Database (Denmark)

    Beghetti, M.; Hoeper, M.M.; Kiely, D.G.;

    2008-01-01

    The oral dual endothelin receptor antagonist bosentan has been shown to improve the short- and medium-term course of adult pulmonary arterial hypertension (PAH); however, data from clinical studies in children are limited. This analysis investigated the safety profile of bosentan in pediatric...... patients in a European, prospective, noninterventional, Internet-based postmarketing surveillance database (Tracleer PMS). Pediatric patients (aged 2-11 y) were compared with patients aged > or =12 y. Over a 30-mo period, 4994 patients, including 146 bosentan-naive pediatric patients (51.4% males), were...... captured in the database. Predominant etiologies in children were idiopathic PAH (40.4%) and PAH related to congenital heart disease (45.2%). The majority of children were in New York Heart Association functional class II (28.1%) or III (50.7%), and median exposure to bosentan was 29.1 wk. Elevated...

  18. A new locus for autosomal recessive non-syndromic mental retardation maps to 1p21.1-p13.3.

    Science.gov (United States)

    Uyguner, O; Kayserili, H; Li, Y; Karaman, B; Nürnberg, G; Hennies, Hc; Becker, C; Nürnberg, P; Başaran, S; Apak, M Y; Wollnik, B

    2007-03-01

    Autosomal recessive inheritance of non-syndromic mental retardation (ARNSMR) may account for approximately 25% of all patients with non-specific mental retardation (NSMR). Although many X-linked genes have been identified as a cause of NSMR, only three autosomal genes are known to cause ARNSMR. We present here a large consanguineous Turkish family with four mentally retarded individuals from different branches of the family. Clinical tests showed cognitive impairment but no neurological, skeletal, and biochemical involvements. Genome-wide mapping using Human Mapping 10K Array showed a single positive locus with a parametric LOD score of 4.92 in a region on chromosome 1p21.1-p13.3. Further analyses using polymorphic microsatellite markers defined a 6.6-Mb critical region containing approximately 130 known genes. This locus is the fourth one linked to ARNSMR.

  19. Mapping of the thermal neutron distribution in the lead block assembly of the PS-211 experiment at CERN, using thermoluminescence and nuclear track detectors

    CERN Document Server

    Savvidis, E; Kitis, G

    2002-01-01

    The main purpose of the TARC (transmutation by adiabatic resonance crossing) experiment (PS-211), was to demonstrate the possibility to destroy efficiently long-lived fission fragments (LLFF) in accelerator driven systems (ADS). The experimental set-up which consisted of a lead block with dimensions 3.3 * 3.3 * 3 m/sup 3/, was installed in a CERN proton synchrotron (PS) beam line. The proton beam at 2.5 GeV/c and 3.5 GeV/c, was incident in the centre of the lead block assembly producing neutrons via spallation reactions. Neutron flux measurements are presented in the lead block assembly using thermoluminescence and nuclear track detectors. The results are in good agreement with Monte Carlo calculations as well as with the results of the other methods used in the framework of the TARC experiment. (5 refs).

  20. Detection of chloronium and measurement of the 35Cl/37Cl isotopic ratio at z=0.89 toward PKS1830-211

    CERN Document Server

    Muller, S; Guelin, M; Henkel, C; Combes, F; Gerin, M; Aalto, S; Beelen, A; Darling, J; Horellou, C; Martin, S; Menten, K M; Dinh-V-Trung,; Zwaan, M A

    2014-01-01

    We report the first extragalactic detection of chloronium (H2Cl+), in the z=0.89 absorber in front of the lensed blazar PKS1830-211. The ion is detected through its 1_11-0_00 line along two independent lines of sight toward the North-East and South-West images of the blazar. The relative abundance of H2Cl+ is significantly higher (by a factor ~7) in the NE line of sight, which has a lower H2/H fraction, indicating that H2Cl+ preferably traces the diffuse gas component. From the ratio of the H2^35Cl+ and H2^37Cl+ absorptions toward the SW image, we measure a 35Cl/37Cl isotopic ratio of 3.1 (-0.2; +0.3) at z=0.89, similar to that observed in the Galaxy and the solar system.

  1. Absorbed Doses and Risk Estimates of (211)At-MX35 F(ab')2 in Intraperitoneal Therapy of Ovarian Cancer Patients

    DEFF Research Database (Denmark)

    Cederkrantz, Elin; Andersson, Håkan; Bernhardt, Peter;

    2015-01-01

    , intraperitoneal (i.p.) targeted α therapy has been proposed as an adjuvant treatment for minimal residual disease after successful primary treatment. In the present study, we calculated absorbed and relative biological effect (RBE)-weighted (equivalent) doses in relevant normal tissues and estimated the effective...... of the infused therapy solution. RESULTS: The urinary bladder, thyroid, and kidneys (1.9, 1.8, and 1.7 mGy per MBq/L) received the 3 highest estimated absorbed doses. When the tissue-weighting factors were applied, the largest contributors to the effective dose were the lungs, stomach, and urinary bladder. Using...... 100 MBq/L, organ equivalent doses were less than 10% of the estimated tolerance dose. CONCLUSION: Intraperitoneal (211)At-MX35 F(ab')2 treatment is potentially a well-tolerated therapy for locally confined microscopic ovarian cancer. Absorbed doses to normal organs are low, but because the effective...

  2. Mapping of the thermal neutron distribution in the lead block assembly of the PS-211 experiment at CERN, using thermoluminescence and nuclear track detectors.

    Science.gov (United States)

    Savvidis, E; Eleftheriadis, C A; Kitis, G

    2002-01-01

    The main purpose of the TARC (Transmutation by Adiabatic Resonance Crossing) experiment (PS-211), was to demonstrate the possibility to destroy efficiently Long-Lived Fission Fragments (LLFF) in Accelerator Driven Systems (ADS). The experimental set-up which consisted of a lead block with dimensions 3.3 x 3.3 x 3 m3, was installed in a CERN Proton Synchrotron (PS) beam line. The proton beam at 2.5 GeV/c and 3.5 GeV/c, was incident in the centre of the lead block assembly producing neutrons via spallation reactions. In this study, neutron flux measurements are presented in the lead block assembly using thermoluminescence and nuclear track detectors. The results are in good agreement with Monte Carlo calculations as well as with the results of the other methods used in the framework of the TARC experiment.

  3. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    OpenAIRE

    Isabella Coimbra Wagner; Murilo José de Barros Guimarães; Lilian Karine Neves da Silva; Francisco Montenegro de Melo; Maria Tereza Cartaxo Muniz

    2007-01-01

    OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA), fragmento da citoqueratina 19 (CYFRA21-1) e antígeno glicosídico associado a tumor 15-3 (CA 15-3) em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi real...

  4. 新しい腫瘍マーカー,Cytokeratin Fragment 21-1 (CYFRA 21-1)の婦人科悪性腫瘍における有用性 : TPA及びCA 125と比較して

    OpenAIRE

    稲葉, 憲之; 深澤, 一雄; 岡嶋, 祐子; 太田, 順子; 岩崎, 秀昭; 松井, 英雄; 高見澤, 裕吉; イナバ, ノリユキ; フカサワ, イチオ; オカジマ, ユウコ; オオタ, ヨリコ; イワサキ, ヒデアキ; マツイ, ヒデオ; タカミザワ, ヒロヨシ; INABA, Noriyuki

    1992-01-01

    本年開発された新しいサイトケラチン関連腫瘍マーカー,CYFRA 21-1の臨床的有用性を婦人科悪性腫瘍において始めて検討し,婦人科において最も汎用されているTPAやCA125を感度及び特異度共に凌駕する成績を得た。

  5. Cavity residue leucine 95 and channel residues glutamine 204, aspartic acid 211, and phenylalanine 269 of toluene o-xylene monooxygenase influence catalysis.

    Science.gov (United States)

    Kurt, Cansu; Sönmez, Burcu; Vardar, Nurcan; Yanık-Yıldırım, K Cansu; Vardar-Schara, Gönül

    2016-09-01

    Structural analysis of toluene-o-xylene monooxygenase (ToMO) hydroxylase revealed the presence of three hydrophobic cavities, a channel, and a pore leading from the protein surface to the active site. Here, saturation mutagenesis was used to investigate the catalytic roles of alpha-subunit (TouA) second cavity residue L95 and TouA channel residues Q204, D211, and F269. By testing the substrates toluene, phenol, nitrobenzene, and/or naphthalene, these positions were found to influence the catalytic activity of ToMO. Several regiospecific variants were identified from TouA positions Q204, F269, and L95. For example, TouA variant Q204H had the regiospecificity of nitrobenzene changed significantly from 30 to 61 % p-nitrophenol. Interestingly, a combination of mutations at Q204H and A106V altered the regiospecificity of nitrobenzene back to 27 % p-nitrophenol. TouA variants F269Y, F269P, Q204E, and L95D improved the meta-hydroxylating capability of nitrobenzene by producing 87, 85, 82, and 77 % m-nitrophenol, respectively. For naphthalene oxidation, TouA variants F269V, Q204A, Q204S/S222N, and F269T had the regiospecificity changed from 16 to 9, 10, 23, and 25 % 2-naphthol, respectively. Here, two additional TouA residues, S222 and A106, were also identified that may have important roles in catalysis. Most of the isolated variants from D211 remained active, whereas having a hydrophobic residue at this position appeared to diminish the catalytic activity toward naphthalene. The mutational effects on the ToMO regiospecificity described here suggest that it is possible to further fine tune and engineer the reactivity of multicomponent diiron monooxygenases toward different substrates at positions that are relatively distant from the active site. PMID:27311562

  6. 我国“211”高校图书馆随书光盘网上服务力评价研究

    Institute of Scientific and Technical Information of China (English)

    孙明华

    2011-01-01

    The book-attached CD-ROM online services power can demonstrate its service level and abilities. The evaluation of the book-attached CDROM online services power consists of four aspects, including system design, system function, reaources organization and reveal, sustainable develop ment, which can be the basis for establishing an evaluation indicator system and a fuzzy comprehensive evaluation model. This paper conducts an empir ical study of the part of the "211" university library and provides suggestions, so as to promote the book-attached CD-ROM network management in the university library.%随书光盘网上服务力是图书馆服务水平与能力的直接体现,随书光盘网上服务力评价内容主要包括系统设计、系统功能、资源组织与揭示、可持续发展等方面,以此可构建高校图书馆随书光盘网上服务力评价指标体系与模糊综合评价模型,本文对部分“211”高校图书馆随书光盘网上服务力进行实证研究并提出建议,以期促进高校图书馆随书光盘的网络化管理。

  7. 影响中国"211工程"大学综合实力的关键因素研究

    Institute of Scientific and Technical Information of China (English)

    李思思

    2016-01-01

    近些年来,国内高等教育方面的专家和学者们一直致力于大学综合实力的影响因素等方面的研究,提出了一系列高等教育评价指标体系,然而因为各评价指标体系中指标及其权重的差异,其评价结果也各异.通过对大学综合实力内涵的探究,总结归纳前人的研究成果,找出可能影响我国"211工程"大学综合实力的关捷因素;并以结构方程法为主要分析工具,构建了大学综合实力评价模型;最后通过SmartPLS软件对样本数据进行分析,验证了影响我国"211工程"大学综合实力的十大关键因素:生师比、教授占教师总数的比例、教师平均学术水平、在校生总数、在校研究生与本科生比、生源质量、图书总量、硕士点数量、博士点数量和国家重点学科数.

  8. 211 undergraduate college students volunteer service under the vision of ideological and political education work%思想政治教育工作视野下的211本科院校大学生志愿服务

    Institute of Scientific and Technical Information of China (English)

    宝月

    2015-01-01

    大学生志愿服务是思想政治教育的重要载体,能够使学生在服务社会的过程中,提升社会责任感,并提高自身素养。然而当前211高校的志愿服务组织存在管理松散、资金缺乏等现实问题,本文着力探讨提高大学生志愿服务组织管理水平、加强人员培训等有效措施,以提升大学生志愿服务活动的思想政治教育价值。%College students’ volunteer service is the important carrier of ideological and political education, to make students in the process of social service, improve social responsibility, and improve their quality. However, the current management loose 211 colleges and universities of voluntary service organizations, the practical problems such as lacking funds etc, this article emphatically discussed to improve the college students volunteer service organization management level, strengthen personnel training and effective measures, to improve the ideological and political education of college students volunteer service activities.

  9. Serum SCCA,Cyfra21-1,EGFR and CyclinD1 levels in patients with oral and maxillofacial malignancy%口腔颌面部恶性肿瘤患者血清中SCCA、Cyfra21-1、EGFR、CyclinD1含量的检测

    Institute of Scientific and Technical Information of China (English)

    冯晓宇; 邢汝东; 鲁大鹏; 李建华; 李金忠; 李华; 韩正学

    2009-01-01

    目的 检测口腔颌面部恶性肿瘤患者血清中鳞状细胞癌相关抗原(SCCA)、细胞角蛋白19可溶性片段(Cyfra 21-1)、表皮生长因子受体(EGFR)和细胞周期素D1(Cyclin D1)的含量,探讨它们的联合检测对口腔颌面部恶性肿瘤的诊断价值,以及与肿瘤临床分期、病理分级和淋巴结转移的关系,并观察手术前后这四种物质的含量变化.方法 选择住院治疗的口腔颌面部恶性肿瘤患者92例,正常对照组72例,肿瘤患者于术前取空腹静脉血2ml,对其中20例患者于术后1周再次取空腹静脉血2ml,正常对照组于常规体检时取空腹静脉血2ml.酶联免疫吸附法测定所有标本血清中SCCA、Cyfra 21-1、EGFR、Cyclin D1的含量.结果 口腔颌面部恶性肿瘤患者术前血清中SCCA、EGFR、Cyclin D1的含量明显高于正常对照组,而Cyfra21-1的含量与对照组相比无显著差异.患者术后1周血清中SCCA的含量明显降低,而Cyfra 21-1、EGFR、Cyclin D1的含量与术前相比无显著差异.肿瘤患者术前血清中SCCA、Cyfra 21-1、EGFR、Cyclin D1的含量与肿瘤的临床分期、分化及淋巴结转移无关.单独检测SCCA、EGFR、Cyclin D1时,EGFR对肿瘤诊断的灵敏度、特异性和准确性最高;SCCA、EGFR、Cyclin D1任意两种联合检测时,EGFR与Cyclin D1联合对肿瘤诊断的灵敏度、特异性和准确性最高,其次是SCCA与EGFR联合;SCCA、EGFR和Cyclin D1三者联合检测的灵敏度、特异性和准确性与EGFR、Cyclin D1联合检测相同.结论 EGFR与Cyclin D1联合检测可提高对口腔颌面部恶性肿瘤诊断的灵敏度、特异性和准确性,对口腔颌面部恶性肿瘤有辅助诊断价值.SCCA可能对治疗效果的监测有参考意义.

  10. Diagnostic Value of Single and Combined Determination of Serum TPS Cyfra21-1 and Ferritin in patients with NSCLC%血清肿瘤标记物对非小细胞肺癌的诊断价值

    Institute of Scientific and Technical Information of China (English)

    刘广军; 谢宗涛

    2012-01-01

    Objective: To investigate the diagnostic value of single and combined determination of serum tissue polypeptide specific antigen( TPS ), cytokeratin 19 fragment(Cyfra21-1 ) and ferritin in patients with non-small cell lung cancer( NSCLC ). Method: The levels of serum TPS were detected in 108 patients with NSCLC and 86 cases of healthy adults by enzyme-linked immunosorbent assay( ELASA ),and the levels of Cyfra21-1 and ferritin were detected by electrochemiluminescence. Result: The serum levels and positive rates of the three tumor markers in lung cancer group were significantly higher than those in healthy adults( P <0. 01 ). TPS showed higher sensitivity than the other two tumor markers in the diagnosis of pulmonary ade-nocarcinoma( P<0. 05 );The serum levels and positive rates of Cyfra21-1 in squamous carcinoma group were significantly higher than those in adenocarcinoma group( P<0. 01 ). TPS showed the highest sensitivity and Cyfra21-1 showed the highest sensitivity in single tumor marker detection; Their combined detection could reduce the specificity to a certain extent,but could significantly improve the sensitivity and the accuracy( P< 0. 01 ). Conclusion: The single and combined detection TPS,cyfra21-l and ferritin has high clinical value in the diagnosis of NSCLC and the differentiation of pathology types.%目的 探讨血清组织多肽特异性抗原( TPS)、细胞角蛋白19片段(Cyfra21-1)和铁蛋白(Ferritin)单项及联合检测对非小细胞肺癌的诊断价值.方法 采用酶联免疫吸附(ELISA)法测定108例NSCLC患者和86例健康人的血清中TPS水平,同时用电化学发光法测定Cyfra21-1和Ferritin水平.结果 肺癌组三项血清肿瘤标记物水平及阳性率均显著高于健康对照组(P<0.01).TPS诊断肺腺癌的敏感性优于其他两项肿瘤标记物(P<0.05);Cyfra21-1在鳞癌组血清浓度及阳性率明显高于腺癌组(P<0.01).三项肿瘤标记物单项检测时,TPS的敏感性最高,Cyfra21-1的特异性

  11. Detection of HF Toward PKS 1830–211, Search for Interstellar H2F+, and Laboratory Study of H2F+ and H2Cl+ Dissociative Recombination

    Science.gov (United States)

    Kawaguchi, K.; Muller, S.; Black, J. H.; Amano, T.; Matsushima, F.; Fujimori, R.; Okabayahsi, Y.; Nagahiro, H.; Miyamoto, Y.; Tang, J.

    2016-05-01

    We report extragalactic observations of two fluorine-bearing species, hydrogen fluoride (HF) and fluoronium (H2F+), in the z = 0.89 absorber in front of the lensed blazar PKS 1830‑211 with the Atacama Large Millimeter/submillimeter Array. HF was detected toward both southwest and northeast images of the blazar, with column densities >3.4 × 1014 cm‑2 and 0.18 × 1014 cm‑2, respectively. H2F+ was not detected, down to an upper limit (3σ) of 8.8 × 1011 cm‑2 and an abundance ratio of [H2F+]/[HF] ≤slant 1/386. We also searched for H2F+ toward the Galactic sources NGC 6334 I and W51C, and toward Galactic center clouds with the Herschel HIFI spectrometer.6 The upper limit on the column density was derived to be 2.5 × 1011 cm‑2 in NGC 6334 I, which is 1/68 of that for H2Cl+. In constrast, the ortho transition of H2Cl+ is detected toward PKS 1830–211. To understand the small abundance of interstellar H2F+, we carried out laboratory experiments to determine the rate constants for the ion–electron recombination reaction by infrared time-resolved spectroscopy. The constants determined are k e (209 K) = (1.1+/- 0.3)× {10}-7 cm3 s‑1 and (0.46+/- 0.05)× {10}-7 cm3 s‑1 for H2F+ and H2Cl+, respectively. The difference in the dissociative recombination rates between H2F+ and H2Cl+ by a factor ∼2 and the cosmic abundance ratio [F]/[Cl] ≈ 1/6 are not enough to explain the much smaller abundance of H2F+. The difference in the formation mechanism of H2F+ and H2Cl+ in interstellar space would be a major factor in the small abundance of H2F+.

  12. 血清细胞角蛋白19片段抗原21-1及鳞状细胞癌抗原在子宫颈癌肺转移患者中的表达及其意义%Expression and prognostic value of cytokeratin 19 fragment antigen 21-1 and squamous cell carcinoma antigen in cervical cancer patients with lung metastasis

    Institute of Scientific and Technical Information of China (English)

    郭开峰; 缪继东

    2016-01-01

    Objective To investigate expression of cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients with lung metastasis before treatment and their prognostic value. Methods The pretreatment serum expression levels of SCC-Ag and CYFRA21-1 of 72 cervical cancer patients with lung metastasis were measured. Survival rate analysis and Cox proportional hazard model were performed to evaluate the prognostic significance of two pretreatment variables. Results The media survival time (MST) of 72 patients was 14 months, and 38 (52.8 %) patients with pulmonary metastasis occurred in 1 year of treatment. The pretreatment serum SCC-Ag and CYFRA21-1 levels in the patients with tumor diameter over 4 cm or with squamous cell carcinoma were higher than those in the other patients (all P3.3 mg/L) was higher than that in the negative group (13 months vs 19 months, P1.5 mg/L) was also higher than that in the negative group (14 months vs 21 months, P<0.05). The result of Cox regression analysis showed that the tumor diameter (OR = 11.6, P = 0.01), pretreatment serum SCC-Ag (OR= 4.2, P= 0.01) and CYFRA21-1 (OR= 8.2, P= 0.05) levels were independent prognostic factors of overall survival. Conclusion Pretreatment CYFRA 21-1 and SCC-Ag levels may be considered as useful prognostic indicators for cervical cancer patients with lung metastasis.%目的:探讨治疗前血清细胞角蛋白19片段抗原21-1(CYFRA21-1)和鳞状细胞癌抗原(SCC-Ag)表达水平在子宫颈癌肺转移患者预后评估中的价值。方法检测72例子宫颈癌肺转移患者治疗前血清CYFRA21-1及SCC-Ag水平,采用生存分析、Cox回归方法分析两项指标对于治疗后患者预后的预测价值。结果72例子宫颈癌肺转移患者中位生存时间为14个月,其中38例(52.8%)肺转移发生在治疗1年内。肿瘤直径>4 cm及病理类型为鳞状细胞癌的患者血清CYFRA21-1、SCC

  13. Radiotoxicity of systemically administered [211At]astatide in B6C3F1 and BALB/C (NU/NU) mice: A long-term survival study with histologic analysis

    International Nuclear Information System (INIS)

    Purpose: The present study undertook to establish the dose (LD) of systemically administered (via tail vein) sodium [211At]astatide that would kill 10% (LD10) of exposed animals in two mouse models and to evaluate the resulting histologic lesions. Methods and Materials: Three dose escalation experiments were carried out using groups of 10 3- to 4-week-old, 20 ± 2 g B6C3F1 mice, and one dose escalation experiment was carried out with groups of 10 4- to 6-week-old, 22 ± 2 g BALB/c (nu/nu) mice. All animals were weighed daily and checked twice daily for general health; autopsies were performed within 12 h of death. Results: The LD10 (95% confidence interval) level of free [211At]astatide at 360 days was 15.1 μCi (5.2-19.1 μCi) in B6C3F1 mice and was associated with a 37.8% weight difference from saline controls (p 10 at 360 days was 7.7 μCi (0-14.2 μCi), while a dose of 10 μCi (0.42 μCi g-1) was associated with a 9.44% weight difference vs. saline controls (p 211At]astatide activity levels were associated with severe bone marrow depression, testicular atrophy, focal alopecia, and nuclear atypia of the epidermoid mucosa of the fore-stomach in the B6C3F1 mice; at activity levels approximating LD10 at 360 days, mild changes in the heart, liver, stomach, and spleen were observed. For BALB/c (nu/nu) mice, administration of 10 μCi was associated at autopsy with mild histologic lesions in the heart, stomach, liver, and spleen. Conclusions: These studies provide a basis for the design of further investigations of [211At]-labeled compounds as therapeutic agents.

  14. The Johnson Space Center Management Information Systems (JSCMIS). 1: Requirements Definition and Design Specifications for Versions 2.1 and 2.1.1. 2: Documented Test Scenario Environments. 3: Security Design and Specifications

    Science.gov (United States)

    1986-01-01

    The Johnson Space Center Management Information System (JSCMIS) is an interface to computer data bases at NASA Johnson which allows an authorized user to browse and retrieve information from a variety of sources with minimum effort. This issue gives requirements definition and design specifications for versions 2.1 and 2.1.1, along with documented test scenario environments, and security object design and specifications.

  15. Clinical Value of Serum HMGB1 Levels in Early Detection of Recurrent Squamous Cell Carcinoma of Uterine Cervix: Comparison with Serum SCCA, CYFRA21-1, and CEA Levels

    OpenAIRE

    Sheng, Xiugui; Du, Xuelian; Zhang, Xiaoling; Li, Dapeng; Lu, Chunhua; Li, Qinshui; Ma, Zhifang; Song, Quqing; Wang, Cong

    2009-01-01

    Aim To evaluate the clinical value of serum high mobility group box chromosomal protein 1 (HMGB1) levels in making the early diagnosis of recurrent cervical squamous cell carcinomas (CSCC) and compare it with the value of serum squamous cell carcinoma antigen (SCCA), cytokeratin fragment (CYFRA) 21-1, and carcinoembryonic antigen (CEA) levels. Methods Immunohistochemical staining of tissue from 64 patients with recurrent CSCCs, 72 patients with non-recurrent carcinoma,...

  16. Two cases of partial trisomy 8p and partial monosomy 21q in a family with a reciprocal translocation (8;21)(p21.1;q22.3).

    OpenAIRE

    Plomp, A.S.; Engelen, J.J.; Albrechts, J C; de Die-Smulders, C E; Hamers, A J

    1998-01-01

    We report on two mentally retarded adults with an unbalanced karyotype resulting from a familial balanced translocation between chromosomes 8 and 21, t(8;21)(p21.1;q22.3). This translocation has not been reported before. Both patients had partial trisomy 8p and partial monosomy 21q. Fluorescence in situ hybridisation (FISH) was used to determine the chromosomal breakpoints more precisely. The first patient showed mild mental retardation and facial dysmorphism, slightly resembling the earlier ...

  17. 76 FR 70336 - Airworthiness Directives; Rolls-Royce plc RB211-524G2-19; -524G2-T-19; -524G3-19; -524G3-T-19...

    Science.gov (United States)

    2011-11-14

    ... April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United States Code... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... plc RB211-524G2-19; -524G2- T-19; -524G3-19; -524G3-T-19; 524H2-19; -524H2-T-19; -524H-36; and -...

  18. Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.

    Science.gov (United States)

    Norton, Elizabeth B; Lawson, Louise B; Freytag, Lucy C; Clements, John D

    2011-04-01

    Despite the fact that the adjuvant properties of the heat-labile enterotoxins of Escherichia coli (LT) and Vibrio cholerae (CT) have been known for more than 20 years, there are no available oral vaccines containing these molecules as adjuvants, primarily because they are both very potent enterotoxins. A number of attempts with various degrees of success have been made to reduce or eliminate the enterotoxicity of LT and CT so they can safely be used as oral adjuvants or immunogens. In this report we characterize the structural, enzymatic, enterotoxic, and adjuvant properties of a novel mutant of LT, designated LT(R192G/L211A), or dmLT. dmLT was not sensitive to trypsin activation, had reduced enzymatic activity for induction of cyclic AMP in Caco-2 cells, and exhibited no enterotoxicity in the patent mouse assay. Importantly, dmLT retained the ability to function as an oral adjuvant for a coadministered antigen (tetanus toxoid) and to elicit anti-LT antibodies. In vitro and in vivo data suggest that the reduced enterotoxicity of this molecule compared to native LT or the single mutant, LT(R192G), is a consequence of increased sensitivity to proteolysis and rapid intracellular degradation in mammalian cells. In conclusion, dmLT is a safe and powerful detoxified enterotoxin with the potential to function as a mucosal adjuvant for coadministered antigens and to elicit anti-LT antibodies without undesirable side effects. PMID:21288994

  19. ‘The woman was deceived and became a sinner’ – a literary-theological investigation of 1 Timothy 2:11–15

    Directory of Open Access Journals (Sweden)

    Abiola I. Mbamalu

    2014-02-01

    Full Text Available In 1 Timothy 2:11–15 women are forbidden to teach and have authority over men in the church. The ground for this instruction is the creation account in Genesis 2 that asserts the priority of Adam over Eve in the order of creation. The second reason for the instruction is the deception of Eve according to the account of the Fall in Genesis 3. This pericope has elicited arguments between advocates of egalitarianism and complementarianism revolving over the issues of grammar, the context of the Ephesian church with regard to false teachings and the comparison of this text with the other writings of Paul, for those that subscribe to the authorship of Paul. The contention of this article is that verse 15 provides a major clue as to how this text should be understood. In addition, the author’s rhetoric in this text is interrogated with regard to the text’s own internal literary and theological logic. In this regard, the author is found to be inconsistent in his outlook, for the grace that was poured out abundantly on him: a blasphemer, a persecutor and a violent man and on account of his ignorance andunbelief (1 Tm 1:12–16 is apparently, being denied women on account of Eve’s deception.

  20. Silver(Ⅰ) Coordination Polymers of 2,11-Dithia[3.3]paracyclophane and in situ Silver(Ⅰ) Perfluoro-dicarboxylates

    Institute of Scientific and Technical Information of China (English)

    LIU,Shuqin; ZHANG,Xiongfu; WANG,Huilong; MENG,Changgong; MOU,Wensheng

    2009-01-01

    Coordination polymers of 2,11-dithia[3.3]paracyclopane (dtpcp) with in situ silver(Ⅰ) perfluoro-dicarboxylates characterized by single crystal X-ray analysis are described.Their structures were found to strongly depend on the dicarboxylates.With disilver(Ⅰ) tetrafluoro-succinate [(CF2)n(COOAg)2,n=2],a ID chain of [Aga(dtpcp)3(C2F4(CO2)2)2]·2CH3OH (1) forms in which two silver(Ⅰ) ions link with two dtpcp ligands to afford a four-numbered ring and disilver(Ⅰ) tetrafluoro-succinates link such rings.Changing the silver salt to disilver(Ⅰ) hexafluoroglutarate [(CF2),(COOAg)2,n=3]produces a 3D structure with composition of [Ag2(dtpcp)(C3F6(CO2)2)](2),in which the disilver(Ⅰ) hexafluoroglutarates connect with each other to form a 1D S-shape chain and dtpcp ligands bridge such chains to give a 3D internet.With disilver(Ⅰ) octafluoroadipate [(CF2)n(COOAg)2,n=4],2D porous sheets of [Ag2(dtpcp)2(C4F8(CO2)2)]·2mesitylene (3) are formed.In polymer 3 four dtpcp and two octafluoroadipates are linked together by silver(Ⅰ) ions to give a cavity in which two guest mesitylene molecules are located.