WorldWideScience

Sample records for actinium 208

  1. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  2. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  3. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  4. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Science.gov (United States)

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development.

  5. Rvx 208.

    Science.gov (United States)

    2011-01-01

    RVX 208 (RVX-208; RVX000222) is a first-in-class novel small molecule in development by Resverlogix Corporation for acute coronary syndromes, atherosclerosis and Alzheimer disease. It increases the levels of apolipoprotein A1 and high-density lipoprotein cholesterol, thereby potentially reducing the risk for cardiovascular disease. This review discusses the key development milestones and therapeutic trials of this drug. This summary has been extracted from Wolters Kluwer's R&D Insight drug pipeline database. R&D Insight tracks and evaluates drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch. This is an open access article published under the terms of the Creative Commons License "Attribution-NonCommercial-NoDerivative 3.0" (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits non-commercial use, distribution, and reproduction, provided the original work is properly cited and not altered.

  6. Relativistic small-core pseudopotentials for actinium, thorium, and protactinium.

    Science.gov (United States)

    Weigand, Anna; Cao, Xiaoyan; Hangele, Tim; Dolg, Michael

    2014-04-03

    Small-core pseudopotentials for actinium, thorium, and protactinium have been energy-adjusted to multiconfiguration Dirac-Hartree-Fock reference data based on the Dirac-Coulomb-Breit Hamiltonian and the Fermi nucleus model. Corresponding optimized valence basis sets of polarized valence quadruple-ζ quality are presented. Atomic test calculations for the first four ionization potentials show satisfactory results at both the Hartree-Fock and the multireference averaged coupled-pair functional level. Highly correlated Fock-space coupled cluster calculations demonstrate that the new pseudopotentials yield ionization potentials, which are in excellent agreement with corresponding all-electron results and experimental data. The pseudopotentials and basis sets supplement a similar set previously published for uranium.

  7. Effects of spin-orbit coupling on actinium under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Rubio-Ponce, A.; Rivera, J. [Departamento de Ciencias Basicas, Universidad Autonoma Metropolitana-Azcapotzalco, Mexico (Mexico); Olguin, D. [Departamento de Fi sica, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico (Mexico)

    2015-04-15

    Actinium (Ac) is a radioactive metal and the first element of the actinide series. At ambient conditions Ac crystallizes in the fcc lattice, however, up to date its phase diagram is unknown. In the present work, we have studied the structural and electronic properties of Ac under hydrostatic pressure assuming the fcc structure as well as three hypothetical structures, namely the hcp, bcc, and sc, and for pressures up to 100 GPa. From our calculations, we found only one structural transition allowed, from the fcc to hcp, our calculated pressure was 39.85 GPa. The calculations were performed by means of the full potential linearized augmented plane wave (FLAPW) method and the generalized gradient approximation (GGA) for the exchange-correlation energy, where we have included in our study the spin-orbit coupling which is important for heavy elements. The total energy results were fitted to the third order Birch-Murnaghan's equation of state. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  8. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  9. 208 Duecento Otto

    Institute of Scientific and Technical Information of China (English)

    周静

    2010-01-01

    JIA Boutique Hotels的创办人Yenn Wong从纽约式意大利菜取得灵感,创立了208 Duecento Otto餐厅及酒吧。208 Duecento Otto座落于香港上环荷李活道208号,餐厅亦因此命名。Yenn喜欢发掘新鲜且有启发性的设计元素,因此时常留意世界各地的新设计师。从商业角度出发,

  10. Report for General Research September 18 to December 11, 1950 (Actinium Volume)

    Energy Technology Data Exchange (ETDEWEB)

    Haring, M.M.

    1951-01-15

    The purpose of the research work presented in this volume is to develop a process for the separation and purification of actinium-227 produced by neutron bombardment of radium-226 and to develop methods by which uniform films of actinium metal may be deposited on metallic surfaces. The design work on the cave structure and mechanical equipment used in the actinium separation is proceeding on schedule. As the mechanical design phase is nearing completion the emphasis is being directed toward processing equipment. The process as well as the mechanical equipment has been adapted from the research work of F. T. Hagemann and the Remote Control Group at Argonne National Laboratory. Consequently, one of the first objectives is to become familiary with the chemistry of the process and the operation of the mechanical equipment. Cold runs have been made on the T.T.A. benzene extraction using lanthanum and barium in place of actinium and radium. No difficulty with the operation was observed. The formation of precipitates was one of the difficulties encountered with the process as the precipitates carry radium. It has been found that metals such as nickel cause these precipitates to form and should, therefore, be avoided in the construction of equipment. it was also found that a T.T.A. solution exposed to 0.5 curie of polonium over a period of days develops a precipitate. Some new mechanical features hav eshown promise. The use of copper-coated glassware which will hold together even though the glass is cracked has made it possible to replace custom-built heaters with standard heating mantles. A new graphite, silicone grease mixture appears to hold up in stopcocks handling benzene and, as a result, may eliminate the necessary of entering the cave for regreasing. Tests on the preparation of dense concrete have given results which meet the shielding requirements for the cave. A strippable paint and tape combination has been studied and specified to provide for decontamination of

  11. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  12. Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

    Science.gov (United States)

    Radchenko, V; Engle, J W; Wilson, J J; Maassen, J R; Nortier, F M; Taylor, W A; Birnbaum, E R; Hudston, L A; John, K D; Fassbender, M E

    2015-02-06

    Actinium-225 (t1/2=9.92d) is an α-emitting radionuclide with nuclear properties well-suited for use in targeted alpha therapy (TAT), a powerful treatment method for malignant tumors. Actinium-225 can also be utilized as a generator for (213)Bi (t1/2 45.6 min), which is another valuable candidate for TAT. Actinium-225 can be produced via proton irradiation of thorium metal; however, long-lived (227)Ac (t1/2=21.8a, 99% β(-), 1% α) is co-produced during this process and will impact the quality of the final product. Thus, accurate assays are needed to determine the (225)Ac/(227)Ac ratio, which is dependent on beam energy, irradiation time and target design. Accurate actinium assays, in turn, require efficient separation of actinium isotopes from both the Th matrix and highly radioactive activation by-products, especially radiolanthanides formed from proton-induced fission. In this study, we introduce a novel, selective chromatographic technique for the recovery and purification of actinium isotopes from irradiated Th matrices. A two-step sequence of cation exchange and extraction chromatography was implemented. Radiolanthanides were quantitatively removed from Ac, and no non-Ac radionuclidic impurities were detected in the final Ac fraction. An (225)Ac spike added prior to separation was recovered at ≥ 98%, and Ac decontamination from Th was found to be ≥ 10(6). The purified actinium fraction allowed for highly accurate (227)Ac determination at analytical scales, i.e., at (227)Ac activities of 1-100 kBq (27 nCi to 2.7 μCi). Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  14. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Energy Technology Data Exchange (ETDEWEB)

    Raeder, S., E-mail: s.raeder@gsi.de [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Bastin, B. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Block, M. [Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Institut für Kernchemie, Johannes Gutenberg Universität, 55128 Mainz (Germany); Creemers, P. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Ferrer, R. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fléchard, X. [LPC Caen, ENSICAEN, Université de Caen, CNRS/IN2P3, Caen (France); Franchoo, S. [Institute de Physique Nucléaire (IPN) d’Orsay, 91406 Orsay, Cedex (France); Ghys, L. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); SCK-CEN, Belgian Nuclear Research Center, Boeretang 200, 2400 Mol (Belgium); Gaffney, L.P.; Granados, C. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Heinke, R. [Institut für Physik, Johannes Gutenberg Universität, 55128 Mainz (Germany); Hijazi, L. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); and others

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  15. 8 CFR 208.2 - Jurisdiction

    Science.gov (United States)

    2010-01-01

    ... jurisdiction over credible fear determinations under § 208.30 and reasonable fear determinations under § 208.31... jurisdiction over asylum applications filed by an alien who has been served a Form I-221, Order to Show Cause... reasonable fear determinations referred to the Immigration Court under § 208.31, and credible fear...

  16. 30 CFR 75.208 - Warning devices.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Warning devices. 75.208 Section 75.208 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Roof Support § 75.208 Warning devices. Except during...

  17. 23 CFR 646.208 - Funding.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Funding. 646.208 Section 646.208 Highways FEDERAL...-Highway Projects § 646.208 Funding. (a) Railroad/highway crossing projects may be funded through the Federal-aid funding source appropriate for the involved project. (b) Projects for the elimination...

  18. 23 CFR 633.208 - Maintenance.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Maintenance. 633.208 Section 633.208 Highways FEDERAL... PROVISIONS Federal-Aid Contracts (Appalachian Contracts) § 633.208 Maintenance. Maintenance of all highway... responsibility of the State. The State may arrange for maintenance of such roads or portions thereof,...

  19. 22 CFR 208.920 - Civil judgment.

    Science.gov (United States)

    2010-04-01

    ... creates a civil liability for the complained of wrongful acts, or a final determination of liability under... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Civil judgment. 208.920 Section 208.920 Foreign...) Definitions § 208.920 Civil judgment. Civil judgment means the disposition of a civil action by any court...

  20. 22 CFR 208.1010 - Suspending official.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Suspending official. 208.1010 Section 208.1010 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 208.1010 Suspending official. (a) Suspending official means an agency official...

  1. 12 CFR 208.4 - Capital adequacy.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Capital adequacy. 208.4 Section 208.4 Banks and... Requirements § 208.4 Capital adequacy. (a) Adequacy. A member bank's capital, as defined in appendix A to this...) Standards for evaluating capital adequacy. Standards and guidelines by which the Board evaluates the...

  2. 30 CFR 90.208 - Bimonthly sampling.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Bimonthly sampling. 90.208 Section 90.208... MANDATORY HEALTH STANDARDS-COAL MINERS WHO HAVE EVIDENCE OF THE DEVELOPMENT OF PNEUMOCONIOSIS Sampling Procedures § 90.208 Bimonthly sampling. (a) Each operator shall take one valid respirable dust sample...

  3. 22 CFR 208.1015 - Suspension.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Suspension. 208.1015 Section 208.1015 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 208.1015 Suspension. Suspension is an action taken by a suspending official under subpart G...

  4. 28 CFR 16.208 - Annual report.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Annual report. 16.208 Section 16.208 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.208 Annual report. The Commission shall report annually...

  5. 40 CFR 92.208 - Certification.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Certification. 92.208 Section 92.208... POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Certification Provisions § 92.208 Certification. (a) This... the application for certification, test reports and data acquired from a freshly...

  6. 40 CFR 94.208 - Certification.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Certification. 94.208 Section 94.208... EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES Certification Provisions § 94.208 Certification. (a) If, after a review of the application for certification, test reports and data acquired from an engine...

  7. 40 CFR 90.208 - Certification.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Certification. 90.208 Section 90.208... EMISSIONS FROM NONROAD SPARK-IGNITION ENGINES AT OR BELOW 19 KILOWATTS Certification Averaging, Banking, and Trading Provisions § 90.208 Certification. (a) In the application for certification a manufacturer...

  8. 5 CFR 179.208 - Certification.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Certification. 179.208 Section 179.208... Salary Offset § 179.208 Certification. (a) OPM salary offset coordinator shall provide a certification to... certification must be in writing and must state: (1) That the employee owes the debt; (2) The amount and...

  9. 48 CFR 208.7002 - Assignment authority.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Assignment authority. 208..., DEPARTMENT OF DEFENSE ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Coordinated Acquisition 208.7002 Assignment authority. (a) Under the DoD Coordinated Acquisition Program,...

  10. 31 CFR 545.208 - Exempt transactions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Exempt transactions. 545.208 Section 545.208 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... assist in the creation of information or informational materials; and, with respect to information or...

  11. 44 CFR 208.43 - Rehabilitation.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Rehabilitation. 208.43... Agreements § 208.43 Rehabilitation. DHS will reimburse costs incurred to return System equipment and... Activation. (3) Personnel costs associated with equipment cache rehabilitation. DHS will reimburse...

  12. 40 CFR 86.208-94 - Dynamometer.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Dynamometer. 86.208-94 Section 86.208-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New...

  13. 14 CFR 1274.208 - Intellectual property.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Intellectual property. 1274.208 Section... WITH COMMERCIAL FIRMS Pre-Award Requirements § 1274.208 Intellectual property. (a) Intellectual property rights. A cooperative agreement covers the disposition of rights to intellectual property...

  14. 42 CFR 93.208 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Evidence. 93.208 Section 93.208 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  15. 5 CFR 430.208 - Rating performance.

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    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Rating performance. 430.208 Section 430.208 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERFORMANCE MANAGEMENT Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees §...

  16. 40 CFR 91.208 - Certification.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Certification. 91.208 Section 91.208... Certification. (a) In the application for certification a manufacturer must: (1) Submit a statement that the engines for which certification is requested will not, to the best of the manufacturer's belief, cause...

  17. Dicty_cDB: VHG208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VH (Link to library) VHG208 (Link to dictyBase) - - - Contig-U16299-1 VHG208P (Link to Original site) VHG20...8F 658 VHG208Z 627 VHG208P 1265 - - Show VHG208 Library VH (Link to library) Clone ID VHG20...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VH/VHG2-A/VHG208Q.Seq.d/ Representative seq. ID VHG20...8P (Link to Original site) Representative DNA sequence >VHG208 (VHG208Q) /CSM/VH/VHG2-A/VHG20...s CSM-cDNA Score E Sequences producing significant alignments: (bits) Value VHG208 (VHG208Q) /CSM/VH/VHG2-A/VHG20

  18. 48 CFR 208.7005 - Military interdepartmental purchase requests.

    Science.gov (United States)

    2010-10-01

    ... purchase requests. 208.7005 Section 208.7005 Federal Acquisition Regulations System DEFENSE ACQUISITION... Coordinated Acquisition 208.7005 Military interdepartmental purchase requests. Follow the procedures at— (a) PGI 253.208-1 when using DD Form 448, Military Interdepartmental Purchase Request; and (b) PGI...

  19. Complete electric dipole response in 208Pb

    CERN Document Server

    Tamii, A; von Neumann-Cosel, P; Fujita, Y; Adachi, T; Bertulani, C A; Carter, J; Dozono, M; Fujita, H; Fujita, K; Hatanaka, K; Heilmann, A M; Ishikawa, D; Itoh, M; Ong, H J; Kawabata, T; Kalmykov, Y; Litvinova, E; Matsubara, H; Nakanishi, K; Neveling, R; Okamura, H; Özel-Tashenov, B; Ponomarev, V Yu; Richter, A; Rubio, B; Sakaguchi, H; Sakemi, Y; Sasamoto, Y; Shimbara, Y; Shimizu, Y; Smit, F D; Suzuki, T; Tameshige, Y; Wambach, J; Yamada, R; Yosoi, M; Zenihiro, J

    2011-01-01

    A benchmark experiment on 208Pb shows that polarized proton inelastic scattering at very forward angles including 0{\\deg} is a powerful tool for high-resolution studies of electric dipole (E1) and spin magnetic dipole (M1) modes in nuclei over a broad excitation energy range testing up-to-date nuclear model calculations. The E1 polarizability extracted from the data provides a constraint on the neutron skin thickness in 208Pb and the poorly known density dependence of the symmetry energy, relevant to the description of neutron stars.

  20. 37 CFR 2.208 - Deposit accounts.

    Science.gov (United States)

    2010-07-01

    ... upon receipt of the statement to cover the value of items or services charged to the account and thus... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Fees and Payment of Money in Trademark Cases § 2.208 Deposit accounts. (a) For the convenience of attorneys, and the general public in paying any fees due, in...

  1. 48 CFR 871.208 - Rehabilitation facilities.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Rehabilitation facilities... Vocational Rehabilitation and Employment Service 871.208 Rehabilitation facilities. Charges by rehabilitation facilities for the rehabilitation services provided under 38 U.S.C. Chapter 31 are paid in the same manner as...

  2. 24 CFR 208.112 - Cost.

    Science.gov (United States)

    2010-04-01

    ... MULTIFAMILY SUBSIDIZED PROJECTS § 208.112 Cost. (a) The costs of the electronic transmission of the correctly... electronic transmission, may include current project operating income; an expense item in processing rent... multiple projects may centralize the electronic transmission function. However, owners that contract out or...

  3. 40 CFR 61.208 - Certification requirements.

    Science.gov (United States)

    2010-07-01

    ... Emissions From Phosphogypsum Stacks § 61.208 Certification requirements. (a)(1) The owner or operator of a stack from which phosphogypsum will be removed and distributed in commerce pursuant to § 61.204, § 61.205, or § 61.206 shall prepare a certification document for each quantity of phosphogypsum which...

  4. 27 CFR 46.208 - Unmerchantable articles.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Unmerchantable articles... Tubes Held for Sale on April 1, 2009 Inventories § 46.208 Unmerchantable articles. Articles that the.... However, the dealer must segregate any such unmerchantable articles and include them in a separate...

  5. Epilepsy 208 Cases Clinical Analysis%癫痫208例临床分析

    Institute of Scientific and Technical Information of China (English)

    吴昊

    2013-01-01

    目的 探讨癫痫患者的临床及脑电图(EEG)改变.方法 对208例癫痫患者EEG进行分析.结果 208例癫痫患者EEG轻度异常55例,中度异常109例,重度异常17例.结论 EEG可为癫痫患者的诊断提供重要依据.

  6. 33 CFR 110.208 - Buffalo Harbor, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buffalo Harbor, N.Y. 110.208 Section 110.208 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.208 Buffalo Harbor, N.Y. (a) The anchorage...

  7. 41 CFR 101-27.208 - Inventory analyses.

    Science.gov (United States)

    2010-07-01

    ...-Management of Shelf-Life Materials § 101-27.208 Inventory analyses. (a) An inventory analysis shall be... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Inventory analyses. 101-27.208 Section 101-27.208 Public Contracts and Property Management Federal Property Management...

  8. 5 CFR 630.208 - Reduction in leave credits.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Reduction in leave credits. 630.208 Section 630.208 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS ABSENCE AND LEAVE Definitions and General Provisions for Annual and Sick Leave § 630.208 Reduction in leave...

  9. 10 CFR 590.208 - Small volume exports.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Small volume exports. 590.208 Section 590.208 Energy... WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS Applications for Authorization To Import or Export Natural Gas § 590.208 Small volume exports. Any person may export up to 100,000 cubic feet of natural...

  10. 50 CFR 665.208 - Protected species conservation.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Protected species conservation. 665.208 Section 665.208 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Fisheries § 665.208 Protected species conservation. The Regional Administrator may change the size of...

  11. 44 CFR 208.26 - Accountability for use of funds.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Accountability for use of funds. 208.26 Section 208.26 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... Preparedness Cooperative Agreements § 208.26 Accountability for use of funds. The Sponsoring Agency...

  12. 42 CFR 50.208 - Program or project requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Program or project requirements. 50.208 Section 50.208 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects § 50.208...

  13. 46 CFR 122.208 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Accidents to machinery. 122.208 Section 122.208 Shipping... Voyage Records § 122.208 Accidents to machinery. The owner, managing operator, or master shall report damage to a boiler, unfired pressure vessel, or machinery that renders further use of the item...

  14. 46 CFR 185.208 - Accidents to machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Accidents to machinery. 185.208 Section 185.208 Shipping...) OPERATIONS Marine Casualties and Voyage Records § 185.208 Accidents to machinery. The owner, managing operator, or master shall report damage to a boiler, unfired pressure vessel, or machinery that...

  15. 9 CFR 113.208 - Avian Encephalomyelitis Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ..., Killed Virus. 113.208 Section 113.208 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.208 Avian Encephalomyelitis Vaccine, Killed Virus....

  16. Pygmy dipole resonance in 208Pb

    CERN Document Server

    Poltoratska, I; Tamii, A; Adachi, T; Bertulani, C A; Carter, J; Dozono, M; Fujita, H; Fujita, K; Fujita, Y; Hatanaka, K; Itoh, M; Kawabata, T; Kalmykov, Y; Krumbholz, A M; Litvinova, E; Matsubara, H; Nakanishi, K; Neveling, R; Okamura, H; Ong, H J; Özel-Tashenov, B; Ponomarev, V Yu; Richter, A; Rubio, B; Sakaguchi, H; Sakemi, Y; Sasamoto, Y; Shimbara, Y; Shimizu, Y; Smit, F D; Suzuki, T; Tameshige, Y; Wambach, J; Yosoi, M; Zenihiro, J

    2012-01-01

    Scattering of protons of several hundred MeV is a promising new spectroscopic tool for the study of electric dipole strength in nuclei. A case study of 208Pb shows that at very forward angles J^pi = 1- states are strongly populated via Coulomb excitation. A separation from nuclear excitation of other modes is achieved by a multipole decomposition analysis of the experimental cross sections based on theoretical angular distributions calculated within the quasiparticle-phonon model. The B(E1) transition strength distribution is extracted for excitation energies up to 9 MeV, i.e., in the region of the so-called pygmy dipole resonance (PDR). The Coulomb-nuclear interference shows sensitivity to the underlying structure of the E1 transitions, which allows for the first time an experimental extraction of the strength and energy centroid of the PDR.

  17. 48 CFR 5152.208-9001 - Industrial preparedness planning.

    Science.gov (United States)

    2010-10-01

    ... planning. 5152.208-9001 Section 5152.208-9001 Federal Acquisition Regulations System DEPARTMENT OF THE ARMY... planning. As prescribed at 5108-070(g)(4) insert the following clause in full text in contracts where the contractor is designated a Limited Fee Planned Producer. Industrial Preparedness Planning (XXX 1989) (DEV) (a...

  18. 9 CFR 93.208 - Articles accompanying poultry.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Articles accompanying poultry. 93.208 Section 93.208 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY,...

  19. 20 CFR 802.208 - Contents of notice of appeal.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Contents of notice of appeal. 802.208 Section 802.208 Employees' Benefits BENEFITS REVIEW BOARD, DEPARTMENT OF LABOR RULES OF PRACTICE AND PROCEDURE... notwithstanding, any written communication which reasonably permits identification of the decision from which...

  20. 8 CFR 208.13 - Establishing asylum eligibility.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Establishing asylum eligibility. 208.13... FOR ASYLUM AND WITHHOLDING OF REMOVAL Asylum and Withholding of Removal § 208.13 Establishing asylum eligibility. (a) Burden of proof. The burden of proof is on the applicant for asylum to establish that he...

  1. 27 CFR 555.208 - Construction of type 2 magazines.

    Science.gov (United States)

    2010-04-01

    ... magazines. 555.208 Section 555.208 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO... Construction of type 2 magazines. A type 2 magazine is a box, trailer, semitrailer, or other mobile facility. (a) Outdoor magazines—(1) General. Outdoor magazines are to be bullet-resistant,...

  2. 48 CFR 208.7003-2 - Assignments under coordinated acquisition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Assignments under coordinated acquisition. 208.7003-2 Section 208.7003-2 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES...

  3. 31 CFR 208.5 - Availability of the ETA SM.

    Science.gov (United States)

    2010-07-01

    ... ETAs SM as Treasury's Financial Agent. A Federally-insured financial institution that elects to offer... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Availability of the ETA SM. 208.5... DISBURSEMENTS § 208.5 Availability of the ETA SM. An individual who receives a Federal benefit, wage, salary,...

  4. 42 CFR 438.208 - Coordination and continuity of care.

    Science.gov (United States)

    2010-10-01

    ... Section 438.208 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Improvement Access Standards § 438.208 Coordination and continuity of care. (a) Basic requirement—(1) General... individual with special health care needs, as specified in paragraph (c) of this section. (3) Exception for...

  5. 7 CFR 205.208-205.235 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements §§ 205.208-205.235...

  6. 7 CFR 62.208 - Publication of QSVP assessment status.

    Science.gov (United States)

    2010-01-01

    ... 62.208 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) LIVESTOCK, MEAT, AND OTHER AGRICULTURAL COMMODITIES (QUALITY SYSTEMS VERIFICATION...

  7. Unusual Threshold Anomaly in the 6Li+208Pb System

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chun-Lei; JIA Hui-Ming; WU Zhen-Dong; XU Xin-Xing; BAI Chun-Lin; ZHANG Huan-Qiao; LIN Cheng-Jian; RUAN Ming; LIU Zu-Hua; YANG Feng; WU Xiu-Kun; ZHOU Ping; AN Guang-Peng

    2006-01-01

    @@ The angular distributions of elastic scattering for the 6Li +208Pb system have been measured at several energies around the Coulomb barrier. The parameters of optical potential are extracted by means of a phenomenological optical model analysis. It is found that the real and imaginal potentials show a pronounced energy dependence.The behaviour of the potential at the nearly especially sub-barrier energies in the 6Li+208Pb system is quite different from the results of some previous reports observed in other systems, such as 19 F +208 Pb and 16 O+208 Pb.This unusual threshold phenomenon indicates that breakup channel is strongly coupled with the elastic channel and has obvious effects on optical potential.

  8. Partial Photoneutron Cross Sections for 207,208Pb

    Science.gov (United States)

    Kondo, T.; Utsunomiya, H.; Goriely, S.; Iwamoto, C.; Akimune, H.; Yamagata, T.; Toyokawa, H.; Harada, H.; Kitatani, F.; Lui, Y.-W.; Hilaire, S.; Koning, A. J.

    2014-05-01

    Using linearly-polarized laser-Compton scattering γ-rays, partial E1 and M1 photoneutron cross sections along with total cross sections were determined for 207,208Pb at four energies near neutron threshold by measuring anisotropies in photoneutron emission. Separately, total photoneutron cross sections were measured for 207,208Pb with a high-efficiency 4π neutron detector. The partial cross section measurement provides direct evidence for the presence of pygmy dipole resonance (PDR) in 207,208Pb in the vicinity of neutron threshold. The strength of PDR amounts to 0.32%-0.42% of the Thomas-Reiche-Kuhn sum rule. Several μN2 units of B(M1)↑ strength were observed in 207,208Pb just above neutron threshold, which correspond to M1 cross sections less than 10% of the total photoneutron cross sections.

  9. The interaction of 11Li with 208Pb

    CERN Document Server

    Vinodkumar, A M; Yanez, R; Leonard, M; Yao, L; Bricault, P; Dombsky, M; Kunz, P; Lassen, J; Morton, A C; Ottewell, D; Preddy, D; Trinczek, M

    2012-01-01

    Background: 11Li is one of the most studied halo nuclei. The fusion of 11Li with 208Pb has been the subject of a number of theoretical studies with widely differing predictions, ranging over four orders of magnitude, for the fusion excitation function. Purpose: To measure the excitation function for the 11Li + 208Pb reaction. Methods: A stacked foil/degrader assembly of 208Pb targets was irradiated with a 11Li beam producing center of target beam energies from above barrier to near barrier energies (40 to 29 MeV). The intensity of the 11Li beam (chopped) was 1250 p/s and the beam on-target time was 34 hours. The alpha-decay of the stopped evaporation residues was detected in a alpha-detector array at each beam energy in the beam-off period (the beam was on for <= 5 ns and then off for 170 ns). Results: The 215At evaporation residues were associated with the fusion of 11Li with 208Pb. The 213,214At evaporation residues were formed by the breakup of 11Li into 9Li + 2n, with the 9Li fusing with 208Pb. The 214...

  10. Coulomb Breakup of Nucleus 6 Li on Ion 208Pb

    OpenAIRE

    Irgaziev, B. F.; ERGASHBAEV, H. T.

    1998-01-01

    In the framework of the three-body approach the A(a,bc)A Coulomb breakup has been investigated. The three-body Coulomb dynamic is taken into account to derive the expression for the reaction matrix element. The mechanism of the breakup includes the direct process and the excitation of resonance state of the particle a. The calculation of the triple differential cross section of the 208Pb(6Li, a d)208Pb Coulomb dissociation have been performed in the energy region Ea d < 1MeV. Cal...

  11. 44 CFR 208.36 - Reimbursement for Alert.

    Science.gov (United States)

    2010-10-01

    ... § 208.41 of this part. (4) Food and beverages for Task Force Members and Support Specialists when DHS does not provide meals during the Alert. DHS will limit food and beverage reimbursement to the amount... where such food and beverages were provided, multiplied by the number of personnel who received them....

  12. 7 CFR 1160.208 - Powers of the Board.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order National Fluid Milk Processor Promotion Board § 1160.208 Powers of the Board. The Board shall...

  13. 23 CFR 450.208 - Coordination of planning process activities.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Coordination of planning process activities. 450.208... Coordination of planning process activities. (a) In carrying out the statewide transportation planning process... planning process shall (to the maximum extent practicable) be consistent with the development of applicable...

  14. 40 CFR 761.208 - Use of the manifest.

    Science.gov (United States)

    2010-07-01

    ... paper to certify that the PCB waste covered by the manifest or shipping paper was received. (ii) Note... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.208 Use of the manifest. (a)(1) The generator of PCB waste shall: (i) Sign the manifest certification by hand. (ii) Obtain the handwritten signature of the...

  15. 20 CFR 725.208 - Determination of relationship; child.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of relationship; child. 725.208... Determination of relationship; child. As used in this section, the term “beneficiary” means only a surviving... considered to be the child of a beneficiary if: (a) The courts of the State in which the beneficiary...

  16. 48 CFR 52.208-4 - Vehicle Lease Payments.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Vehicle Lease Payments. 52....208-4 Vehicle Lease Payments. As prescribed in 8.1104(a), insert the following clause in solicitations...: Vehicle Lease Payments (APR 1984) (a) Upon the submission of proper invoices or vouchers, the...

  17. 44 CFR 208.27 - Title to equipment.

    Science.gov (United States)

    2010-10-01

    ... Cooperative Agreements § 208.27 Title to equipment. Title to equipment purchased by a Sponsoring Agency with funds provided under a DHS Preparedness Cooperative Agreement vests in the Sponsoring Agency, provided that DHS reserves the right to transfer title to the Federal Government or a third party that DHS...

  18. 12 CFR 208.50 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ... MEMBERSHIP OF STATE BANKING INSTITUTIONS IN THE FEDERAL RESERVE SYSTEM (REGULATION H) Real Estate Lending and Appraisal Standards § 208.50 Authority, purpose, and scope. (a) Authority. Subpart E of Regulation H (12 CFR... in adopting internal real estate lending policies. The standards applicable to appraisals rendered...

  19. 5 CFR 734.208 - Participation in fundraising.

    Science.gov (United States)

    2010-01-01

    ... Section 734.208 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... require personal solicitations of contributions, such as organizing mail or phone solicitations for... may organize or manage fundraising activities as long as he or she does not violate the above...

  20. Micro-RNA-208a, -208b, and -499 as Biomarkers for Myocardial Damage After Cardiac Surgery in Children.

    Science.gov (United States)

    Bolkier, Yoav; Nevo-Caspi, Yael; Salem, Yishay; Vardi, Amir; Mishali, David; Paret, Gideon

    2016-04-01

    To test the hypothesis that cardiac-enriched micro-RNAs can serve as accurate biomarkers that reflect myocardial injury and to predict the postoperative course following pediatric cardiac surgery. Micro-RNAs have emerged as plasma biomarkers for many pathologic states. We aimed to quantify preoperative and postoperative plasma levels of cardiac-enriched micro-RNA-208a, -208b, and -499 in children undergoing cardiac surgery and to evaluate correlations between their levels, the extent of myocardial damage, and the postoperative clinical course. PICU. Thirty pediatric patients that underwent open heart surgery for the correction of congenital heart defects between January 2012 to July 2013. None. At 12 hours post surgery, the plasma levels of the micro-RNAs increased by 300- to 4,000-fold. At 24 hours, their levels decreased but remained significantly higher than before surgery. Micro-RNA levels were associated with troponin levels, longer cardiopulmonary bypass and aortic crossclamp times, maximal postoperative aspartate aminotransferase levels, and delayed hospital discharge. Circulating micro-RNA-208a, -208b, and -499 are detectable in the plasma of children undergoing cardiac surgery and may serve as novel biomarkers for monitoring and forecasting postoperative myocardial injury and recovery.

  1. 20 CFR 655.208 - Temporary labor certification applications involving fraud or willful misrepresentation.

    Science.gov (United States)

    2010-04-01

    ... involving fraud or willful misrepresentation. 655.208 Section 655.208 Employees' Benefits EMPLOYMENT AND... Temporary labor certification applications involving fraud or willful misrepresentation. (a) If possible fraud or willful misrepresentation involving a temporary labor certification application is discovered...

  2. 5 CFR 792.208 - What is the definition of executive agency?

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What is the definition of executive agency? 792.208 Section 792.208 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL... Legislation and to Whom Does It Apply? § 792.208 What is the definition of executive agency? The term...

  3. 5 CFR 295.208 - Restrictions that apply to released records.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Restrictions that apply to released records. 295.208 Section 295.208 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... LEGAL PROCEEDINGS Requests for Testimony and Production of Documents § 295.208 Restrictions that...

  4. DIRECT PROTON DECAY FROM THE GAMOW-TELLER RESONANCE IN BI-208

    NARCIS (Netherlands)

    AKIMUNE, H; DAITO, [No Value; FUJITA, Y; FUJIWARA, M; GREENFIELD, MB; HARAKEH, MN; INOMATA, T; JANECKE, J; KATORI, K; NAKAYAMA, S; SAKAI, H; SAKEMI, Y; TANAKA, M; YOSOI, M

    1995-01-01

    Spin-isospin excitations in Bi-208 have been investigated using the Pb-208(He-3,t)Bi-208 reaction at and near theta approximate to 0 degrees at E(He-3)=450 MeV. The microscopic structure of the Gamow-Teller resonance (GTR), the isobaric analog state (IAS), and the spin-flip dipole (Delta L = 1) reso

  5. 12 CFR Appendix D-2 to Part 208 - Interagency Guidelines Establishing Information Security Standards

    Science.gov (United States)

    2010-01-01

    ... (REGULATION H) Pt. 208, App. D-2 Appendix D-2 to Part 208—Interagency Guidelines Establishing Information..., collect, store, use, transmit, protect, or dispose of customer information. g. Service provider means any... (OTS). 2 12 CFR part 30, app. B (OCC); 12 CFR part 208, app. D-2 and part 225, app. F (Board); 12 CFR...

  6. Multinucleon transfer reactions in the 40Ar+208Pb system

    Science.gov (United States)

    Mijatović, T.; Szilner, S.; Corradi, L.; Montanari, D.; Pollarolo, G.; Fioretto, E.; Gadea, A.; Goasduff, A.; Malenica, D. Jelavić; Mǎrginean, N.; Milin, M.; Montagnoli, G.; Scarlassara, F.; Soić, N.; Stefanini, A. M.; Ur, C. A.; Valiente-Dobón, J. J.

    2016-12-01

    We measured multinucleon transfer reactions in the 40Ar+208Pb system at an energy close to the Coulomb barrier, by employing the PRISMA magnetic spectrometer. We extracted differential and total cross sections of the different transfer channels, with a careful investigation of the total kinetic energy loss distributions. Comparisons between different systems having the same 208Pb target and with projectiles going from neutron-poor to neutron-rich nuclei, i.e., 40Ca, 58Ni, and 40Ar, as well as between the data and GRAZING calculations have been carried out. The neutron-rich (stable) 40Ar beam allowed us to get access to the channels involving proton pickup, whose behavior in connection with the production of neutron-rich heavy partner has been outlined.

  7. Broad spectrum moderators and advanced reflector filters using 208Pb

    DEFF Research Database (Denmark)

    Schönfeldt, Troels; Batkov, K.; Klinkby, Esben Bryndt

    2015-01-01

    thermalizing property of 208Pb to design a broad spectrum moderator, i.e. a moderator which emits thermal and cold neutrons from the same position. Using 208Pb as a reflector filter material is shown to be slightly less efficient than a conventional beryllium reflector filter. However, when surrounding...... the reflector filter by a cold moderator it is possible to regain the neutrons with wavelengths below the Bragg edge, which are suppressed in the beryllium reflector filter. In both the beryllium and lead case surrounding the reflector filter with a cold moderator increases the cold brightness significantly......Cold and thermal neutrons used in neutrons scattering experiments are produced in nuclear reactors and spallation sources. The neutrons are cooled to thermal or cold temperatures in thermal and cold moderators, respectively. The present study shows that it is possible to exploit the poor...

  8. Azimuthal anisotropy of photon and charged particle emission in Pb-208+Pb-208 collisions at 158 center dot A GeV/c

    NARCIS (Netherlands)

    Aggarwal, MM; Ahammed, Z; Angelis, ALS; Antonenko, [No Value; Arefiev, [No Value; Astakhov, [No Value; Avdeitchikov, [No Value; Awes, TC; Baba, PVKS; Badyal, SK; Bathe, S; Batiounia, B; Bernier, T; Bhatia, VS; Blume, C; Bucher, D; Busching, H; Carlen, L; Chattopadhyay, S; Decowski, MP; Delagrange, H; Donni, P; Majumdar, MRD; Dubey, AK; El Chenawi, K; Enosawa, K; Fokin, S; Frolov, [No Value; Ganti, MS; Garpman, S; Gavrishchuk, O; Geurts, FJM; Ghosh, TK; Glasow, R; Gupta, R; Guskov, B; Gustafsson, H.A.; Gutbrod, HH; Hrivnacova, [No Value; Ippolitov, M; Kalechofsky, H; Kamermans, R; Karadjev, K; Karpio, K; Kolb, BW; Kosarev, [No Value; Koutcheryaev, [No Value; Kugler, A; Kulinich, P; Kurata, M; Lebedev, A; Löhner, H; Luquin, L; Mahapatra, DP; Manko, [No Value; Martin, M; Martinez, G; Maximov, A; Miake, Y; Mishra, GC; Mohanty, B; Mora, MJ; Morrison, D; Moukhanova, T; Mukhopadhyay, DS; Naef, H; Nandi, BK; Nayak, SK; Nayak, TK; Nianine, A; Nikitine, [No Value; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, P; Nystrand, J; Oskarsson, A; Otterlund, [No Value; Peitzmann, T; Peressounko, D; Phatak, SC; Pinganaud, W; Plasil, F; Purschke, ML; Rak, J; Raniwala, R; Raniwala, S; Rao, NK; Retiere, F; Reygers, K; Roland, G; Rosselet, L; Roufanov, [No Value; Roy, C; Rubio, JM; Sambyal, SS; Santo, R; Sato, S; Schlagheck, H; Schutz, Y; Shabratova, G; Shah, TH; Sharma, A; Sibiriak, [No Value; Siemiarczuk, T; Silvermyr, D; Sinha, BC; Slavine, N; Soderstrom, K; Sood, G; Sorensen, SP; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A; Tykarski, L; van der Phjll, EC; van Eijndhoven, N; van Nieuwenhuizen, GJ; Vinogradov, A; Viyogi, YP; Vodopianov, A; Voros, S; Wyslouch, B; Young, GR

    The azimuthal distributions of photons and charged particles with respect to the event plane are investigated as a function of centrality in Pb-208 + Pb-208 collisions at 158 (.) A GeV/c in the WA98 experiment at the CERN SPS. The anisotropy of the azimuthal distributions is characterized using a

  9. Near barrier scattering of 8He on 208Pb

    Directory of Open Access Journals (Sweden)

    Marquínez-Durán G.

    2014-03-01

    Full Text Available The exotic nucleus 8He is investigated by means of the measurement of the angular distributions of the elastic channel and the 6He and 4He fragment yields produced in the collision with a 208Pb target at two energies around the Coulomb barrier, 16 and 22 MeV. The experiment was performed at the GANIL-SPIRAL facility, with the aim of extracting information about the structure of 8He and the relevant reaction mechanisms. In this contribution, details of the experimental setup and preliminary data on elastic cross sections are reported.

  10. Cluster Decay of 208-238Th Isotopes

    Science.gov (United States)

    Oudih, M. R.; Saidi, F.; Fellah, M.; Allal, N. H.

    2015-11-01

    The cluster radioactivity of 208-238Th was studied by using a fission-like model taking interacting potential as the sum of coulomb and proximity potentials. The emission of the particle is considered as a quantum tunneling penetration of the potential barrier in the semi-classical WKB approximation. The released energy is deduced from the new table of atomic mass evaluation (AME12) and from the Finite Range Droplet Model. The obtained decay half-lives are compared with the few available experimental values and those of the effective liquid drop model.

  11. Neutron skin of (208)pb from coherent pion photoproduction.

    Science.gov (United States)

    Tarbert, C M; Watts, D P; Glazier, D I; Aguar, P; Ahrens, J; Annand, J R M; Arends, H J; Beck, R; Bekrenev, V; Boillat, B; Braghieri, A; Branford, D; Briscoe, W J; Brudvik, J; Cherepnya, S; Codling, R; Downie, E J; Foehl, K; Grabmayr, P; Gregor, R; Heid, E; Hornidge, D; Jahn, O; Kashevarov, V L; Knezevic, A; Kondratiev, R; Korolija, M; Kotulla, M; Krambrich, D; Krusche, B; Lang, M; Lisin, V; Livingston, K; Lugert, S; MacGregor, I J D; Manley, D M; Martinez, M; McGeorge, J C; Mekterovic, D; Metag, V; Nefkens, B M K; Nikolaev, A; Novotny, R; Owens, R O; Pedroni, P; Polonski, A; Prakhov, S N; Price, J W; Rosner, G; Rost, M; Rostomyan, T; Schadmand, S; Schumann, S; Sober, D; Starostin, A; Supek, I; Thomas, A; Unverzagt, M; Walcher, Th; Zana, L; Zehr, F

    2014-06-20

    Information on the size and shape of the neutron skin on (208)Pb is extracted from coherent pion photoproduction cross sections measured using the Crystal Ball detector together with the Glasgow tagger at the MAMI electron beam facility. On exploitation of an interpolated fit of a theoretical model to the measured cross sections, the half-height radius and diffuseness of the neutron distribution are found to be c(n)=6.70±0.03(stat.)  fm and a(n)=0.55±0.01(stat.)(-0.03)(+0.02)(sys.)  fm, respectively, corresponding to a neutron skin thickness Δr(np)=0.15±0.03(stat.)(-0.03)(+0.01)(sys.)  fm. The results give the first successful extraction of a neutron skin thickness with an electromagnetic probe and indicate that the skin of (208)Pb has a halo character. The measurement provides valuable new constraints on both the structure of nuclei and the equation of state for neutron-rich matter.

  12. The neutron skin of $^{208}$Pb from coherent pion photoproduction

    CERN Document Server

    Tarbert, C M; Glazier, D I; Aguar, P; Ahrens, J; Annand, J R M; Arends, H J; Beck, R; Bekrenev, V; Boillat, B; Braghieri, A; Branford, D; Briscoe, W J; Brudvik, J; Cherepnya, S; Codling, R; Downie, E J; Foehl, K; Grabmayr, P; Gregor, R; Heid, E; Hornidge, D; Jahn, O; Kashevarov, V L; Knezevic, A; Kondratiev, R; Korolija, M; Kotulla, M; Krambrich, D; Krusche, B; Lang, M; Lisin, V; Livingston, K; Lugert, S; MacGregor, I J D; Manley, D M; Martinez, M; McGeorge, J C; Mekterovic, D; Metag, V; Nefkens, B M K; Nikolaev, A; Novotny, R; Owens, R O; Pedroni, P; Polonski, A; Prakhov, S N; Price, J W; Rosner, G; Rost, M; Rostomyan, T; Schadmand, S; Schumann, S; Sober, D; Starostin, A; Supek, I; Thomas, A; Unverzagt, M; Walcher, Th; Zehr, F

    2013-01-01

    Information on the size and shape of the neutron skin on $^{208}$Pb has been extracted from coherent pion photoproduction cross sections measured using the Crystal Ball together with the Glasgow tagger at the MAMI electron beam facility. Exploiting an interpolated fit of a theoretical model to the measured cross sections the half-height radius and diffuseness of the neutron distribution are found to be 6.77$\\pm 0.03(stat)$ fm and 0.55$\\pm 0.01(stat)$$^{+0.00}_{-0.025}(sys)$ fm respectively, corresponding to a neutron skin thickness $\\Delta r_{np}$=0.19$\\pm 0.03(stat)$$^{+0.00}_{-0.03}(sys)$ fm. The results give the first successful extraction of a neutron skin with an electromagnetic probe and indicate the skin of $^{208}$Pb has a halo character. The measurement provides valuable new constraints on both the structure of nuclei and the equation of state for neutron rich matter.

  13. Direct proton decay and microscopic structure of the spin-dipole resonance in Bi-208

    NARCIS (Netherlands)

    Akimune, H; Daito, [No Value; Fujita, Y; Fujiwara, M; Harakeh, MN; Janecke, J; Yosoi, M

    2000-01-01

    The microscopic structure of the spin-dipole resonance (SDR) at E-x = 21.1 MeV in Bi-208 has been investigated in the Pb-208(He-3,t)Bi-208 reaction at E(He-3) = 450 MeV and very forward scattering angles. Protons emitted due to the decay of the SDR were measured in solid-state detectors in coinciden

  14. Microscopic description of elastic and inelastic proton scattering from 208Pb

    CERN Document Server

    Dupuis, M; Bauge, E; Delaroche, J P; Gogny, D

    2005-01-01

    Information on the equation of state (EOS) of neutron matter may be gained from studies of 208Pb. Descriptions of 208Pb require credible models of structure, taking particular note also of the spectrum. Such may be tested by analyses of scattering data. Herein, we report on such analyses using an RPA model for 208Pb in a folding model of the scattering. No a posteriori adjustment of parameters are needed to obtain excellent agreement with data. From those analyses, the skin thickness of 208Pb is constrained to lie in the range 0.13-0.17 fm.

  15. [The epidemiological and clinical features of 208 patients with trichinosis].

    Science.gov (United States)

    Wang, Z; Cui, J; Jin, X

    1996-06-01

    In order to know the epidemiological and clinical features of trichinosis, the data of 208 patients with trichinosis from 1992 to 1994 were analysed. The results showed that these patients came from 11 districts, and acquired the infection mainly by tasting the raw pork filling for dumplings or ingesting instant-boiled pork or mutton. The incidence of trichinosis is high in winter. Young and middle-aged workers and cadres constituted the majority of the patients and the infection was more common in the males than in females. The main clinical manifestations of trichinosis were prolonged fever, general myalgia, muscle weekness and eosinophilia. Most of the patients had no gastrointestinal symptoms and skin eruption. Eyelid edema was only seen in the early stage. Serological tests were significant value in the diagnosis of trichinosis. The key measures to prevent trichinosis were that meat inspection should be strictly carried out and bad eating habit changed.

  16. Realistic shell model; 132Sn region; 208Pb region

    CERN Document Server

    Covello, A; Gargano, A; Itaco, N

    2008-01-01

    We report on a study of exotic nuclei around doubly magic 132Sn in terms of the shell model employing a realistic effective interaction derived from the CD-Bonn nucleon-nucleon potential. The short-range repulsion of the latter is renormalized by constructing a smooth low-momentum potential, V-low-k, that is used directly as input for the calculation of the effective interaction. In this paper, we focus attention on proton-neutron multiplets in the odd-odd nuclei 134Sb, 136Sb. We show that the behavior of these multiplets is quite similar to that of the analogous multiplets in the counterpart nuclei in the 208Pb region, 210Bi and 212Bi.

  17. Search for the two-phonon octupole vibrational state in {sup 208}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Blumenthal, D.J.; Henning, W.; Janssens, R.V.F. [and others

    1995-08-01

    We performed an experiment to search for the two-phonon octupole vibrational state in {sup 208}Pb. Thick targets of {sup 208}Pb, {sup 209}Bi, {sup 58,64}Ni, and {sup 160}Gd were bombarded with 1305 MeV beams of were bombard {sup 208}Pb supplied by ATLAS. Gamma rays were detected using the Argonne-Notre Dame BGO gamma-ray facility, consisting of 12 Compton-suppressed germanium detectors surrounding an array of 50 BGO scintillators. We identified some 30 known gamma rays from {sup 208}Pb in the spectra gated by the 5{sup -} {yields} 3{sup -} and 3{sup -} {yields} 0{sup +} transitions in {sup 208}Pb. In addition, after unfolding these spectra for Compton response, we observed broad coincident structures in the energy region expected for the 2-phonon states. Furthermore, we confirmed the placement of a 2485 keV line observed previously in {sup 207}Pb and find no evidence consistent with the placement of this line in {sup 208}Pb. We are currently in the process of investigating the origin of the broadened lines observed in the spectra, extracting the excitation probability of states in {sup 208}Pb, and determining the relative probability of mutual excitation and neutron transfer in this reaction. An additional experiment is also being performed to collect much higher statistics germanium-germanium coincidence data for the thick {sup 208}Pb target.

  18. 8 CFR 208.5 - Special duties toward aliens in custody of DHS.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Special duties toward aliens in custody of DHS. 208.5 Section 208.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION... duties toward aliens in custody of DHS. (a) General. When an alien in the custody of DHS requests asylum...

  19. 8 CFR 208.12 - Reliance on information compiled by other sources.

    Science.gov (United States)

    2010-01-01

    ... Reliance on information compiled by other sources. (a) In deciding an asylum application, or in deciding... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Reliance on information compiled by other sources. 208.12 Section 208.12 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION...

  20. 34 CFR 682.208 - Due diligence in servicing a loan.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Due diligence in servicing a loan. 682.208 Section 682.208 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM General...

  1. 48 CFR 3027.208 - Use of patented technology under the North American Free Trade Agreements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Use of patented technology under the North American Free Trade Agreements. 3027.208 Section 3027.208 Federal Acquisition... American Free Trade Agreements. (f) Contracting officers shall ensure compliance. ...

  2. 44 CFR 208.38 - Reimbursement for re-supply and logistics costs incurred during Activation.

    Science.gov (United States)

    2010-10-01

    ... and logistics costs incurred during Activation. 208.38 Section 208.38 Emergency Management and...-supply and logistics costs incurred during Activation. With the exception of emergency procurement... this subpart, DHS will not reimburse costs incurred for re-supply and logistical support during...

  3. 33 CFR 263.24 - Authority for snagging and clearing for flood control (Section 208).

    Science.gov (United States)

    2010-07-01

    ... clearing for flood control (Section 208). 263.24 Section 263.24 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS Flood Control Policy § 263.24 Authority for snagging and clearing for flood control (Section 208). (a)...

  4. 24 CFR 51.208 - Reservation of administrative and legal rights.

    Science.gov (United States)

    2010-04-01

    ... Reservation of administrative and legal rights. Publication of these standards does not constitute a waiver of... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Reservation of administrative and legal rights. 51.208 Section 51.208 Housing and Urban Development Office of the Secretary, Department...

  5. 23 CFR 973.208 - Indian lands pavement management system (PMS).

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Indian lands pavement management system (PMS). 973.208... HIGHWAYS MANAGEMENT SYSTEMS PERTAINING TO THE BUREAU OF INDIAN AFFAIRS AND THE INDIAN RESERVATION ROADS PROGRAM Bureau of Indian Affairs Management Systems § 973.208 Indian lands pavement management system...

  6. 31 CFR Appendix B to Part 208 - Model Disclosure for Use After ETA SM Becomes Available

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Model Disclosure for Use After ETA SM... FEDERAL AGENCY DISBURSEMENTS Pt. 208, App. B Appendix B to Part 208—Model Disclosure for Use After ETA SM... through a basic, low-cost account called an ETA SM. If you receive a Federal benefit, wage, salary,...

  7. 31 CFR Appendix A to Part 208 - Model Disclosure for Use Until ETA SM Becomes Available

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Model Disclosure for Use Until ETA SM... FEDERAL AGENCY DISBURSEMENTS Pt. 208, App. A Appendix A to Part 208—Model Disclosure for Use Until ETA SM... wait for a basic, low-cost account, called an ETA SM, to become available. If you do not have...

  8. 12 CFR 208.3 - Application and conditions for membership in the Federal Reserve System.

    Science.gov (United States)

    2010-01-01

    ... approval. If an applying bank conforms to all the requirements of the Federal Reserve Act and this section... section 21 of the Federal Reserve Act (12 U.S.C. 486), the Board waives the requirement for the submission... the Federal Reserve System. 208.3 Section 208.3 Banks and Banking FEDERAL RESERVE SYSTEM BOARD...

  9. 12 CFR 208.35 - Qualification requirements for transactions in certain securities. [Reserved

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Qualification requirements for transactions in certain securities. 208.35 Section 208.35 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM MEMBERSHIP OF STATE BANKING INSTITUTIONS IN THE FEDERAL RESERVE...

  10. 48 CFR 253.208-2 - DD Form 448-2, Acceptance of MIPR.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 448-2, Acceptance... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.208-2 DD Form 448-2, Acceptance of MIPR. Follow the procedures at PGI 253.208-2 for use of DD Form 448-2....

  11. 42 CFR 57.208 - Health professions student loan promissory note and disclosure requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Health professions student loan promissory note and disclosure requirements. 57.208 Section 57.208 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND... promissory note and disclosure requirements. (a) Promissory note form. Each health professions student loan...

  12. 24 CFR 92.208 - Eligible community housing development organization (CHDO) operating expense and capacity...

    Science.gov (United States)

    2010-04-01

    ... development organization (CHDO) operating expense and capacity building costs. 92.208 Section 92.208 Housing... community housing development organization (CHDO) operating expense and capacity building costs. (a) Up to 5... expenses of community housing development organizations (CHDOs). These funds may not be used to pay...

  13. 21 CFR 208.20 - Content and format of a Medication Guide.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Content and format of a Medication Guide. 208.20... (CONTINUED) DRUGS: GENERAL MEDICATION GUIDES FOR PRESCRIPTION DRUG PRODUCTS General Requirements for a Medication Guide § 208.20 Content and format of a Medication Guide. (a) A Medication Guide shall meet all...

  14. 45 CFR 400.208 - Claims involving family units which include both refugees and nonrefugees.

    Science.gov (United States)

    2010-10-01

    ... refugees and nonrefugees. 400.208 Section 400.208 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Federal Funding Federal Funding for Expenditures for...

  15. 12 CFR 208.43 - Capital measures and capital category definitions.

    Science.gov (United States)

    2010-01-01

    ... definitions. 208.43 Section 208.43 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM MEMBERSHIP OF STATE BANKING INSTITUTIONS IN THE FEDERAL RESERVE SYSTEM (REGULATION H...-based capital ratio; (2) The Tier 1 risk-based capital ratio; and (3) The leverage ratio. (b)...

  16. MicroRNA-208b inhibits human osteosarcoma progression by targeting ROR2.

    Science.gov (United States)

    Jiang, Zhe; Jiang, Chunshan; Yu, Chonglong; Fang, Jinnv

    2017-06-01

    MicroRNAs are widely involved in cancer progression by inhibiting the expression levels of oncogenes or tumor suppressor genes, and dysregulation of microRNAs may contribute to tumorigenesis. Here, we found that overexpressed miR-208b can reduce the proliferation of human osteosarcoma cell lines U-2OS and Saos-2 by arresting cell cycle progression. The in vivo xenograft tumors induced by Saos-2 cells overexpressing miR-208b had smaller size and grew more slowly than those induced by the control cells. The mobility of U-2OS or Saos-2 cells was also downregulated by miR-208b. MiR-208b targeted a site in the 3' untranslated region of receptor tyrosine kinase-like orphan receptor 2. Inhibition of receptor tyrosine kinase-like orphan receptor 2 suppresses osteosarcoma metastasis in vitro. Recovering the expression levels of receptor tyrosine kinase-like orphan receptor 2 in miR-208b-overexpressed U-2OS or Saos-2 cells attenuated the inhibitory effects of miR-208b. In addition, the expression levels of miR-208b are significantly reduced in human osteosarcoma tissue samples compared to normal tissue samples, and miR-208b levels correlated inversely with receptor tyrosine kinase-like orphan receptor 2 levels. On these bases, we identified that miR-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR-208b can regulate the development of osteosarcoma.

  17. Kinematics of the Compact Symmetric Object OQ 208 - revisited

    CERN Document Server

    Wu, Fang; Baan, Willem A; Hong, Xiao-Yu; Stanghellini, Carlo; Frey, Sandor; Xu, Hai-Guang; Liu, Xiang; Wang, Jingying

    2012-01-01

    Aims. A long timeline kinematic study of the archetypal CSO OQ 208 sheds light on the physical properties of the most compact radio sources. Methods. Archival data from the VLBA at 15 GHz over a time span of 13.6 yr are used to investigate the kinematics of the radio source. The flux density monitoring data obtained at the Michigan 26-meter radio telescope are also used as supplementary information. Results. At 8.4 and 15 GHz, the two lobes are resolved into two sub-components, identified as hotspots. A knotty jet is linked with the NE hotspot and traces back toward the geometric center. The core is too weak to be detected. Significant flux density variation is found in the primary hotspots with the maximum level of 62% (NE1) and 19% (SW1). The peak in the flux density of NE1 leads that of SW1 by approximately 5.00 yr, suggesting that the northeast lobe is advancing and the southwest lobe is receding. This light travel difference indicates a radial distance difference between the two hotspots of 1.53 pc, whic...

  18. 47 CFR 95.208 - (R/C Rule 8) How high may I put my antenna?

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false (R/C Rule 8) How high may I put my antenna? 95.208 Section 95.208 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL... § 95.208 (R/C Rule 8) How high may I put my antenna? (a) Antenna means the radiating system...

  19. 22 CFR 208.305 - May I enter into a covered transaction with an excluded or disqualified person?

    Science.gov (United States)

    2010-04-01

    ... excluded or disqualified person? 208.305 Section 208.305 Foreign Relations AGENCY FOR INTERNATIONAL... Regarding Transactions Doing Business with Other Persons § 208.305 May I enter into a covered transaction... transaction with an excluded person, unless the U.S. Agency for International Development grants an...

  20. 22 CFR 208.320 - Must I verify that principals of my covered transactions are eligible to participate?

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Must I verify that principals of my covered transactions are eligible to participate? 208.320 Section 208.320 Foreign Relations AGENCY FOR INTERNATIONAL... Regarding Transactions Doing Business with Other Persons § 208.320 Must I verify that principals of...

  1. 22 CFR 208.205 - Why is it important to know if a particular transaction is a covered transaction?

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Why is it important to know if a particular transaction is a covered transaction? 208.205 Section 208.205 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Covered Transactions § 208.205 Why is...

  2. 20 CFR 652.208 - How are core services and intensive services related to the methods of service delivery described...

    Science.gov (United States)

    2010-04-01

    ... related to the methods of service delivery described in § 652.207(b)(2)? 652.208 Section 652.208... FUNCTIONING OF STATE EMPLOYMENT SERVICES Wagner-Peyser Act Services in a One-Stop Delivery System Environment § 652.208 How are core services and intensive services related to the methods of service...

  3. Anharmonicity of multi-octupole-phonon excitations in $^{208}$Pb: analysis with multi-reference covariant density functional theory and subbarrier fusion of $^{16}$O+$^{208}$Pb

    CERN Document Server

    Yao, J M

    2016-01-01

    We discuss anharmonicity of the multi-octupole-phonon states in $^{208}$Pb based on a covariant density functional theory, by fully taking into account the interplay between the quadrupole and the octupole degrees of freedom. Our results indicate the existence of a large anharmonicity in the transition strengths, even though the excitation energies are similar to those in the harmonic limit. We also show that the quadrupole-shape fluctuation significantly enhances the fragmentation of the two-octupole-phonon states in $^{208}$Pb. Using those transition strengths as inputs to coupled channels calculations, we then discuss the fusion reaction of $^{16}$O+$^{208}$Pb at energies around the Coulomb barrier. We show that the anharmonicity of the octupole vibrational excitation considerably improves previous coupled-channels calculations in the harmonic oscillator limit, significantly reducing the height of the main peak in the fusion barrier distribution.

  4. One-and Two-Neutron Transfer Reactions in 11Be+208Pb and Mechanism of Lowering Fusion Barrier

    Institute of Scientific and Technical Information of China (English)

    WANG Ning; LI Zhu-Xia; WU Xi-Zhen; WANG Nan; SUN Xiu-Quan

    2000-01-01

    We study one-and two-neutron transfer reactions in 11Be+208Pb by using the quantum molecular dynamics model. We find that lowering about 1-2 MeV of the potential barrier of 208Pb for fusion is gained when two neutrons separated from 11Be enter into 208Pb. Whereas no significant change of potential barrier is found when only the halo neutron separated from 11Be enters into 208Pb. The dynamical interplay between suppression and enhancement effects on the fusion probability in reaction 11Be+208Pb stemming from the easy separation of halo neutron and the long extending of neutron distribution is discussed.

  5. Has a thick neutron skin in ${}^{208}$Pb been ruled out?

    CERN Document Server

    Fattoyev, F J

    2013-01-01

    The Lead Radius Experiment (PREX) has provided the first model-independent evidence in favor of a neutron-rich skin in ${}^{208}$Pb. Although the error bars are large, the reported large central value of 0.33\\,fm is particularly intriguing. To test whether such a thick neutron-skin in ${}^{208}$Pb is already incompatible with laboratory experiments or astrophysical observations, we employ relativistic models with neutron-skin thickness in ${}^{208}$Pb ranging from 0.16 to 0.33 fm to compute ground state properties of finite nuclei, their collective monopole and dipole response, and mass-{\\sl vs}-radius relations for neutron stars. No compelling reason was found to rule out models with large neutron skins in ${}^{208}$Pb from the set of observables considered in this work.

  6. 8 CFR 208.22 - Effect on exclusion, deportation, and removal proceedings.

    Science.gov (United States)

    2010-01-01

    ... may not be deported or removed unless his or her asylum status is terminated pursuant to § 208.24. An... deportation, or deferral of removal, may not be deported or removed to the country to which his or...

  7. Broad spectrum moderators and advanced reflector filters using 208Pb

    OpenAIRE

    Schönfeldt, Troels; Batkov, K.; Klinkby, Esben Bryndt; Lauritzen, Bent; F.Mezei; Muhrer, G.; PITCHER, E; Takibayev, A.; Willendrup, Peter Kjær; Zanini, L.

    2015-01-01

    Cold and thermal neutrons used in neutrons scattering experiments are produced in nuclear reactors and spallation sources. The neutrons are cooled to thermal or cold temperatures in thermal and cold moderators, respectively. The present study shows that it is possible to exploit the poor thermalizing property of 208Pb to design a broad spectrum moderator, i.e. a moderator which emits thermal and cold neutrons from the same position. Using 208Pb as a reflector filter material is shown to be sl...

  8. Chaos and Regularity in the Doubly Magic Nucleus 208Pb

    Science.gov (United States)

    Dietz, B.; Heusler, A.; Maier, K. H.; Richter, A.; Brown, B. A.

    2017-01-01

    High-resolution experiments have recently lead to a complete identification (energy, spin, and parity) of 151 nuclear levels up to an excitation energy of Ex=6.20 MeV in 208Pb [Heusler et al., Phys. Rev. C 93, 054321 (2016), 10.1103/PhysRevC.93.054321]. We present a thorough study of the fluctuation properties in the energy spectra of the unprecedented set of nuclear bound states. In a first approach, we group states with the same spin and parity into 14 subspectra, analyze standard statistical measures for short- and long-range correlations, i.e., the nearest-neighbor spacing distribution, the number variance Σ2, the Dyson-Mehta Δ3 statistics, and the novel distribution of the ratios of consecutive spacings of adjacent energy levels in each energy sequence, and then compute their ensemble average. Their comparison with a random matrix ensemble which interpolates between Poisson statistics expected for regular systems and the Gaussian orthogonal ensemble (GOE) predicted for chaotic systems shows that the data are well described by the GOE. In a second approach, following an idea of Rosenzweig and Porter [Phys. Rev. 120, 1698 (1960), 10.1103/PhysRev.120.1698], we consider the complete spectrum composed of the independent subspectra. We analyze their fluctuation properties using the method of Bayesian inference involving a quantitative measure, called the chaoticity parameter f , which also interpolates between Poisson (f =0 ) and GOE statistics (f =1 ). It turns out to be f ≈0.9 . This is so far the closest agreement with a GOE observed in the spectra of bound states in a nucleus. The same analysis is also performed with spectra computed on the basis of shell model calculations with different interactions (surface-delta interaction, Kuo-Brown, Michigan-three-Yukawa). While the simple surface-delta interaction exhibits features typical for nuclear many-body systems with regular dynamics, the other, more realistic interactions yield chaoticity parameters f close

  9. Changes in cardiac specific microRNA-208a level in peripheral blood in ST segment elevation acute myocardial infarction patients

    Institute of Scientific and Technical Information of China (English)

    姚怡

    2013-01-01

    Objective To observe serum cardiac specific microRNA-208a(miR-208a) levels in ST segment elevation acute myocardial infarction(STEAMI) patients,and to explore the role of serum miR-208a levels in the diagnosis of STEAMI. Methods The serum miR-208a concentrations were assessed within 12 hours after STEAMI,while

  10. Scattering of 9Li on 208Pb at energies around the Coulomb barrier

    Directory of Open Access Journals (Sweden)

    Moro A.

    2011-10-01

    Full Text Available In order to study the dynamics of 11Li and 9Li beams in a strong electric field at energies around the Coulomb barrier, we measured at the ISACII-TRIUMF Facility the angular distribution of elastic and inelastic scattering of 11Li+208Pb at 24.2 and 29.7 MeV and 9Li+208Pb at 24, 29.5 and 33 MeV laboratory energies. We present here the first determination of the angular distribution of the cross section of 9Li+208Pb. The results are compared with theoretical calculations using the double-folding São Paulo Potential (SPP for the real part and a for the imaginary part a Woods-Saxon potential. A good overall agreement is obtained.

  11. On the mixing strength in the two lowest 0- states in 208Pb

    CERN Document Server

    Heusler, A; Hertenberger, R; Krücken, R; Riess, F; Von Brentano, P; Wirth, H F

    2006-01-01

    With a resolution of 3 keV, the two lowest 0- states in 208Pb are identified by measurements of the reaction 207Pb(d, p) with the Muenchen Q3D magnetic spectrograph in a region where the average level spacing is 6 keV. Precise relative spectroscopic factors are determined. Matrix elements of the residual interaction among one-particle one-hole configurations in a two-level scheme are derived for the two lowest 0- states in 208Pb. The off-diagonal mixing strength is determined as 105 +-10(experimental) +-40(systematic) keV. Measurements of the reaction 208Pb(p,p') via isobaric analog resonances in 209Bi support the structure information obtained.

  12. Neutron skin of 208Pb, nuclear symmetry energy, and the parity radius experiment

    CERN Document Server

    Roca-Maza, X; Viñas, X; Warda, M

    2011-01-01

    A precise determination of the neutron skin thickness of a heavy nucleus sets a basic constraint on the nuclear symmetry energy. The parity radius experiment (PREX) may achieve it by model-independent parity-violating electron scattering on 208Pb. We investigate parity-violating electron scattering in nuclear mean field approach to allow the accurate extraction of the neutron skin thickness of 208Pb from the parity-violating asymmetry that the experiment measures. We demonstrate a close linear correlation between the parity-violating asymmetry and the neutron skin thickness in successful mean field forces as a best means to constrain the neutron skin of 208Pb from this innovative experiment. The quality of the correlation supports the commissioning of an improved PREX run to measure the parity-violating asymmetry more accurately. We study the consequences for constraining the density slope of the nuclear symmetry energy.

  13. Electrical Conductivity of ε-Iron under Shock Compression up to 208 G Pa

    Institute of Scientific and Technical Information of China (English)

    毕延; 谭华; 经福谦

    2002-01-01

    The electrical conductivity of shock-compressed iron was measured up to 208 GPa by using an improved design in experiment assembly in which the iron sample was encapsulated in a single-crystal sapphire cell. High-pressure shock compressions were generated by the plate impact technique with the two-stage light-gas gun. The measured conductivity ofiron varies from 1.45 × 104 Ω- 1 cm-1 at 101 GPa and 2010 K to 7.65 × 103 Ω-1 cm-1 at 208 GPa and 5220 K. After examining these data together with those reported, we found that the Bloch-Griineisen expression is still valid at high pressures and temperatures, even up to 208GPa and 5220K, at least for ε-iron, which is significant in the field of condensed matter physics and deep interior earth science.

  14. beta. -. gamma. directional correlations in the. beta. -decay of /sup 208/Tl

    Energy Technology Data Exchange (ETDEWEB)

    Rosso, O.A.; Krmpotic, F.; Szybisz, L.

    1984-02-13

    The relevance of the quenching effects induced by charge-exchange collective fields and ..delta..-isobar-hole excitations is discussed in the case of the ..beta..-..gamma.. angular correlations in the decay of /sup 208/Tl to the 5/sup -//sub 1/, 4/sup -//sub 1/ and 5/sup -//sub 2/ levels in /sup 208/Pb. It is found that, although these effects give rise to a large hindrance of the ..beta..-moments, they influence the anisotropy factor only very weakly. Satisfactory agreement between theoretical predictions and experimental data is obtained for all the transitions.

  15. Disentangling the transfer and breakup contributions from the inclusive ^{8}Li+ ^{208}Pb reaction

    CERN Document Server

    Moro, A M; García-Martínez, H; Aguilera, E F; Martínez-Quiroz, E; Gómez-Camacho, J

    2003-01-01

    An analysis of the elastic and one-neutron removal channel for the reaction (^{8})Li+(^{208})Pb reaction at energies around the Coulomb barrier is presented. For the elastic scattering, an optical model analysis of the experimental data is performed. The observed (^{7})Li is interpreted as the superposition of the one-neutron transfer reaction, (^{208})Pb((^{8})Li,(^{7} )Li)(^{209})Pb, and the breakup reaction. The separate contribution of each one of these processes has been calculated within the DWBA formalism. The sum of both contributions explains adequately the experimental angular distribution of (^{7})Li.

  16. miR-208-induced epithelial to mesenchymal transition of pancreatic cancer cells promotes cell metastasis and invasion.

    Science.gov (United States)

    Liu, Anan; Shao, Chenghao; Jin, Gang; Liu, Rui; Hao, Jun; Song, Bin; Ouyang, Liu; Hu, Xiangui

    2014-06-01

    The aim of this study was to investigate the role of miR-208 in the invasion and metastasis of pancreatic cancer cells and the underlying molecular mechanism. miR-208 mimic, miR-208 inhibitor and NC were transfected into pancreatic cancer cell line Bxpc3 using liposome. Transwell invasion and scratch assays were used to test cell migratory and invasive abilities. Western blotting and quantitative PCR methods were used to detect E-cadherin, fibronectin and vimentin protein and mRNA expression in pancreatic cancer cell line BxPC3 after transfection by miR-208 mimic, miR-208 inhibitor and NC. Transwell invasion and scratch assays showed that after overexpressing miR-208, pancreatic cancer cell line BxPC3 exhibited enhanced in vitro migratory and invasive abilities, while after downregulating miR-208 expression, cell migratory and invasive abilities were decreased. Western blotting and quantitative PCR showed that after overexpressing miR-208, expression of E-cadherin, an epithelial cell marker, was decreased and expression of fibronectin and vimentin, interstitial cell markers, was increased in pancreatic cancer cell line BxPC3; however, after inhibiting miR-208, increased E-cadherin expression and decreased fibronectin and vimentin expression were observed in pancreatic cancer cell line BxPC3. After overexpressing miR-208, p-AKT and p-GSK-3β expression was altered by activating AKT/GSK-3β/snail signaling pathway. miR-208 induces epithelial to mesenchymal transition of pancreatic cancer cell line BxPC3 by activating AKT/GSK-3β/snail signaling pathway and thereby promotes cell metastasis and invasion.

  17. 44 CFR 208.34 - Agreements between Sponsoring Agencies and others.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Agreements between Sponsoring... SYSTEM Response Cooperative Agreements § 208.34 Agreements between Sponsoring Agencies and others. Sponsoring Agencies are responsible for executing such agreements with Participating Agencies and Affiliated...

  18. 49 CFR 24.208 - Aliens not lawfully present in the United States.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Aliens not lawfully present in the United States... Requirements § 24.208 Aliens not lawfully present in the United States. (a) Each person seeking relocation... of an individual, that he or she is either a citizen or national of the United States, or an alien...

  19. 8 CFR 208.30 - Credible fear determinations involving stowaways and applicants for admission found inadmissible...

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Credible fear determinations involving... REGULATIONS PROCEDURES FOR ASYLUM AND WITHHOLDING OF REMOVAL Credible Fear of Persecution § 208.30 Credible fear determinations involving stowaways and applicants for admission found inadmissible pursuant to...

  20. 18 CFR 154.208 - Service of tariff filings on customers and other parties.

    Science.gov (United States)

    2010-04-01

    ... SCHEDULES AND TARIFFS Procedures for Changing Tariffs § 154.208 Service of tariff filings on customers and... customers and state regulatory commissions that have made a standing request for such service. (c) Within... section, service upon the designated recipient will be deemed service upon the customer or other party. (e...

  1. Complete Electric Dipole Response and the Neutron Skin in Pb-208

    NARCIS (Netherlands)

    Tamii, A.; Poltoratska, I.; von Neumann-Cosel, P.; Fujita, Y.; Adachi, T.; Bertulani, C. A.; Carter, J.; Dozono, M.; Fujita, H.; Fujita, K.; Hatanaka, K.; Ishikawa, D.; Itoh, M.; Kawabata, T.; Kalmykov, Y.; Krumbholz, A. M.; Litvinova, E.; Matsubara, H.; Nakanishi, K.; Neveling, R.; Okamura, H.; Ong, H. J.; Oezel-Tashenov, B.; Ponomarev, V. Yu.; Richter, A.; Rubio, B.; Sakaguchi, H.; Sakemi, Y.; Sasamoto, Y.; Shimbara, Y.; Shimizu, Y.; Smit, F. D.; Suzuki, T.; Tameshige, Y.; Wambach, J.; Yamada, R.; Yosoi, M.; Zenihiro, J.

    2011-01-01

    A benchmark experiment on Pb-208 shows that polarized proton inelastic scattering at very forward angles including 0 degrees is a powerful tool for high-resolution studies of electric dipole (E1) and spin magnetic dipole (M1) modes in nuclei over a broad excitation energy range to test up-to-date nu

  2. 40 CFR 33.208 - How long does an MBE or WBE certification from EPA last?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false How long does an MBE or WBE... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Certification § 33.208 How long does an MBE or WBE certification from EPA last? Once EPA OSDBU certifies an entity to be an MBE or WBE by placing it on the EPA OSDBU...

  3. 44 CFR 208.63 - Request by DHS for supplemental information.

    Science.gov (United States)

    2010-10-01

    ... RESPONSE SYSTEM Reimbursement Claims and Appeals § 208.63 Request by DHS for supplemental information. (a... request. (b) If DHS makes a request for supplemental information at any stage of the reimbursement and... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Request by DHS for...

  4. 33 CFR 208.22 - Twin Buttes Dam and Reservoir, Middle and South Concho Rivers, Tex.

    Science.gov (United States)

    2010-07-01

    ... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE FLOOD CONTROL REGULATIONS § 208.22 Twin Buttes Dam..., shall operate the Twin Buttes Dam and Reservoir in the interest of flood control as follows: (a... elevation 1,969.1 (top of flood control pool) the flood control discharge facilities shall be operated...

  5. 33 CFR 208.26 - Altus Dam and Reservoir, North Fork Red River, Okla.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE FLOOD CONTROL REGULATIONS § 208.26 Altus Dam and Reservoir... Dam and Reservoir in the interest of flood control as follows: (a) Flood control storage in the reservoir between elevation 1559 (top of conservation pool) and elevation 1562 (top of flood control...

  6. 33 CFR 208.33 - Cheney Dam and Reservoir, North Fork of Ninnescah River, Kans.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE FLOOD CONTROL REGULATIONS § 208.33 Cheney Dam and Reservoir... the Cheney Dam and Reservoir in the interest of flood control as follows: (a) Flood control storage in... 1429.0 (top of the flood control pool), and initially amounts to 80,860 acre-feet. Whenever...

  7. 33 CFR 208.28 - Foss Dam and Reservoir, Washita River, Oklahoma.

    Science.gov (United States)

    2010-07-01

    ... THE ARMY, DEPARTMENT OF DEFENSE FLOOD CONTROL REGULATIONS § 208.28 Foss Dam and Reservoir, Washita... flood control as follows: (a) Whenever the reservoir level is between elevation 1652.0, top of conservation pool, and elevation 1668.6, top of flood control pool, the flood control discharge...

  8. 33 CFR 208.34 - Norman Dam and Lake Thunderbird, Little River, Okla.

    Science.gov (United States)

    2010-07-01

    ... OF THE ARMY, DEPARTMENT OF DEFENSE FLOOD CONTROL REGULATIONS § 208.34 Norman Dam and Lake Thunderbird... Thunderbird in the interest of flood control as follows: (a) Flood control storage in Lake Thunderbird between elevation 1039 (top of the conservation pool) and elevation 1049.4 (top of flood control pool)...

  9. 33 CFR 208.32 - Sanford Dam and Lake Meredith, Canadian River, Tex.

    Science.gov (United States)

    2010-07-01

    ... OF THE ARMY, DEPARTMENT OF DEFENSE FLOOD CONTROL REGULATIONS § 208.32 Sanford Dam and Lake Meredith... Lake Meredith in the interest of flood control as follows: (a) Flood control storage in the reservoir... elevation range, the flood control discharge facilities shall be operated under the direction of...

  10. 33 CFR 208.29 - Arbuckle Dam and Lake of the Arbuckles, Rock Creek, Okla.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE FLOOD CONTROL REGULATIONS § 208.29 Arbuckle Dam and Lake of the... Dam and Lake of the Arbuckles in the interest of flood control as follows: (a) Flood control storage... flood control pool) initially amounts to 36,400 acre-feet. Whenever the lake level is within...

  11. 30 CFR 208.4 - Royalty oil sales to eligible refiners.

    Science.gov (United States)

    2010-07-01

    ... Royalty Oil” required by 30 CFR 208.5. (b) Sale to eligible refiners. (1) Upon a determination by the... of crude oil at equitable prices, the Secretary, at his or her discretion, may elect to take in kind... determined for that oil pursuant to 30 CFR part 206 had the royalties been paid in value rather than taken...

  12. 8 CFR 208.24 - Termination of asylum or withholding of removal or deportation.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Termination of asylum or withholding of... IMMIGRATION REGULATIONS PROCEDURES FOR ASYLUM AND WITHHOLDING OF REMOVAL Asylum and Withholding of Removal § 208.24 Termination of asylum or withholding of removal or deportation. (a) Termination of asylum...

  13. 8 CFR 208.20 - Determining if an asylum application is frivolous.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Determining if an asylum application is... REGULATIONS PROCEDURES FOR ASYLUM AND WITHHOLDING OF REMOVAL Asylum and Withholding of Removal § 208.20 Determining if an asylum application is frivolous. For applications filed on or after April 1, 1997,...

  14. 8 CFR 208.9 - Procedure for interview before an asylum officer.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Procedure for interview before an asylum... REGULATIONS PROCEDURES FOR ASYLUM AND WITHHOLDING OF REMOVAL Asylum and Withholding of Removal § 208.9 Procedure for interview before an asylum officer. (a) The Service shall adjudicate the claim of each...

  15. 7 CFR 761.208 - Target participation rates for socially disadvantaged groups.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Target participation rates for socially disadvantaged... Farm Loan Programs Funds to State Offices § 761.208 Target participation rates for socially disadvantaged groups. (a) General. (1) The Agency establishes target participation rates for providing FO and OL...

  16. 12 CFR 208.22 - Community development and public welfare investments.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Community development and public welfare...) Investments and Loans § 208.22 Community development and public welfare investments. (a) Definitions. For... Reserve Act (12 U.S.C. 338a), or a community development investment under Regulation Y (12 CFR...

  17. New Isomers in the Neutron-Rich Region Beyond 208Pb

    Directory of Open Access Journals (Sweden)

    Gottardo A.

    2014-03-01

    Full Text Available The region of neutron-rich nuclei beyond 208Pb has been very difficult to explore due to its high mass and exoticity. However, recent experimental improvements allowed one to perform a quite extended isomer decay spectroscopy of these nuclei.

  18. 33 CFR 157.208 - Dedicated Clean Ballast Tanks Operations Manual for foreign tank vessels: Submission.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Dedicated Clean Ballast Tanks... MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.208 Dedicated Clean Ballast Tanks Operations Manual for foreign tank...

  19. 14 CFR 302.208 - Petitions for oral presentation or judge's decision.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Petitions for oral presentation or judge's... TRANSPORTATION (AVIATION PROCEEDINGS) PROCEDURAL REGULATIONS RULES OF PRACTICE IN PROCEEDINGS Rules Applicable to... Applications § 302.208 Petitions for oral presentation or judge's decision. (a) Any person may file a...

  20. 48 CFR 315.208 - Submission, modification, revision, and withdrawal of proposals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Submission, modification... and Receipt of Proposals and Information 315.208 Submission, modification, revision, and withdrawal of... Acquisition, if an HCA determines that certain classes of biomedical or behavioral R & D acquisitions...

  1. 48 CFR 253.208-1 - DD Form 448, Military Interdepartmental Purchase Request.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 448, Military... DD Form 448, Military Interdepartmental Purchase Request. Follow the procedures at PGI 253.208-1 for use of DD Form 448....

  2. 18 CFR 1304.208 - Shoreline stabilization on TVA-owned residential access shoreland.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Shoreline stabilization... OF STRUCTURES AND OTHER ALTERATIONS TVA-Owned Residential Access Shoreland § 1304.208 Shoreline... landowners to stabilize eroding shorelines on TVA-owned residential access shoreland. TVA will determine...

  3. 12 CFR 347.208 - Assessment base deductions by insured branch.

    Science.gov (United States)

    2010-01-01

    ... STATEMENTS OF GENERAL POLICY INTERNATIONAL BANKING Foreign Banks § 347.208 Assessment base deductions by insured branch. Deposits in an insured branch to the credit of the foreign bank or any of its offices, branches, agencies, or wholly owned subsidiaries may be deducted from the assessment base of the...

  4. 48 CFR 1852.208-81 - Restrictions on Printing and Duplicating.

    Science.gov (United States)

    2010-10-01

    ... not perform, or procure from any commercial source, any printing in connection with the performance of... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Restrictions on Printing... Provisions and Clauses 1852.208-81 Restrictions on Printing and Duplicating. As prescribed in...

  5. 12 CFR 208.25 - Loans in areas having special flood hazards.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Loans in areas having special flood hazards...) Investments and Loans § 208.25 Loans in areas having special flood hazards. (a) Purpose and scope—(1) Purpose. The purpose of this section is to implement the requirements of the National Flood Insurance Act of...

  6. Elastic scattering of 17O+208Pb at energies near the Coulomb barrier

    Directory of Open Access Journals (Sweden)

    Torresi D.

    2016-01-01

    Full Text Available Within the frame of the commissioning of a new experimental apparatus EXPADES we undertook the measurement of the elastic scattering angular distribution for the system 17O+208Pb at energy around the Coulomb barrier. The reaction dynamics induced by loosely bound Radioactive Ion Beams is currently being extensively studied [4]. In particular the study of the elastic scattering process allows to obtain direct information on the total reaction cross section of the exotic nuclei. In order to understand the effect of the low binding energy on the reaction mechanism it is important to compare radioactive weakly bound nuclei with stable strongly-bound nuclei. In this framework the study of the 17O+208Pb elastic scattering can be considered to be complementary to a previous measurement of the total reaction cross section for the system 17F+208Pb at energies of 86, 90.4 MeV [5, 6]. The data will be compared with those obtained for the neighboring systems 16,18O+208Pb and others available in literature.

  7. Elastic scattering of 17O+208Pb at energies near the Coulomb barrier

    Science.gov (United States)

    Torresi, D.; Strano, E.; Mazzocco, M.; Boiano, A.; Boiano, C.; Di Meo, P.; La Commara, M.; Manea, C.; Nicoletto, M.; Grebosz, J.; Guglielmetti, A.; Molini, P.; Parascandolo, C.; Pierroutsakou, D.; Signorini, C.; Soramel, F.; Toniolo, N.; Filipescu, D.; Gheorghe, A.; Glodariu, T.; Jeong, S.; Kim, Y. H.; Lay, J. A.; Miyatake, H.; Pakou, A.; Sgouros, O.; Soukeras, V.; Stroe, L.; Vitturi, A.; Watanabe, Y.; Zerva, K.

    2016-05-01

    Within the frame of the commissioning of a new experimental apparatus EXPADES we undertook the measurement of the elastic scattering angular distribution for the system 17O+208Pb at energy around the Coulomb barrier. The reaction dynamics induced by loosely bound Radioactive Ion Beams is currently being extensively studied [4]. In particular the study of the elastic scattering process allows to obtain direct information on the total reaction cross section of the exotic nuclei. In order to understand the effect of the low binding energy on the reaction mechanism it is important to compare radioactive weakly bound nuclei with stable strongly-bound nuclei. In this framework the study of the 17O+208Pb elastic scattering can be considered to be complementary to a previous measurement of the total reaction cross section for the system 17F+208Pb at energies of 86, 90.4 MeV [5, 6]. The data will be compared with those obtained for the neighboring systems 16,18O+208Pb and others available in literature.

  8. Charmed mesic nuclei Bound D and over D states with 208Pb

    CERN Document Server

    Tsushima, K; Thomas, A W; Saitô, K; Landau, Rubin H

    1999-01-01

    We show that the $D^-$ meson will inevitably form narrow bound states with $^{208}$Pb. The experimental confirmation and comparison with the $\\bar{D}^0$ and $D^0$ will provide distinctive information on the nature of the interaction between the charmed meson and matter.

  9. 7 CFR 1744.208 - Rural development investments before November 28, 1990.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Rural development investments before November 28... GUARANTEED AND INSURED TELEPHONE LOANS Borrower Investments § 1744.208 Rural development investments before... by RUS as a condition to approving a rural development investment before November 28, 1990,...

  10. 21 CFR 208.24 - Distributing and dispensing a Medication Guide.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Distributing and dispensing a Medication Guide... SERVICES (CONTINUED) DRUGS: GENERAL MEDICATION GUIDES FOR PRESCRIPTION DRUG PRODUCTS General Requirements for a Medication Guide § 208.24 Distributing and dispensing a Medication Guide. (a) The...

  11. 78 FR 22761 - Delegation of Functions Under Sections 404 and 406 of Public Law 112-208

    Science.gov (United States)

    2013-04-16

    ... 404 and 406 of Public Law 112-208 Presidential Determination No. 2013-07 of April 8, 2013..., 2013 Delegation of Functions Under Sections 404 and 406 of Public Law 112-208 Memorandum for the..., I hereby delegate the functions conferred upon the President by sections 404 and 406 of Public...

  12. 9 CFR 381.208 - Poultry products offered for entry and entered to be handled and transported as domestic; entry...

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Poultry products offered for entry and entered to be handled and transported as domestic; entry into official establishments; transportation. 381.208 Section 381.208 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND...

  13. 23 CFR 636.208 - May I use my existing prequalification procedures with design-build contracts?

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false May I use my existing prequalification procedures with design-build contracts? 636.208 Section 636.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Selection Procedures, Award...

  14. Nuclear level densities in 208Bi and 209Po from the neutron spectra in the ( p, n) reactions on 208Pb and 209Bi nuclei

    Science.gov (United States)

    Zhuravlev, B. V.; Lychagin, A. A.; Titarenko, N. N.; Demenkov, V. G.; Trykova, V. I.

    2010-07-01

    The spectra of neutrons from the ( p, n) reactions on the 208Pb and 209Bi nuclei were measured in the proton-energy range 8-11 MeV. These measurements were performed by using a time-of-flight spectrometer of fast neutrons on the basis of the pulsed tandem accelerator EGP-15 of the Institute of Physics and Power Engineering (Obninsk, Russian Federation). A high resolution and stability of the time-of-flight spectrometermade it possible to identify reliably low-lying discrete levels alongwith the continuum section of the neutron spectra. The measured data were analyzed on the basis of the statistical equilibrium and preequilibrium models of nuclear reactions. The respective calculations were performed by using the precise formalism of Hauser-Feshbach statistical theory together with the generalizedmodel of a superfluid nucleus and the back-shifted Fermi gas model for the nuclear-level density. The nuclear-level densities in 208Bi and 209Po were determined along with their energy dependences and model parameters. Our results are discussed together with available experimental data and recommendations of model systematics.

  15. Evaluation of SD-208, a TGF-β-RI Kinase Inhibitor, as an Anticancer Agent in Retinoblastoma.

    Science.gov (United States)

    Fadakar, Puran; Akbari, Abolfazl; Ghassemi, Fariba; Mobini, Gholam Reza; Mohebi, Masoumeh; Bolhassani, Manzar; Abed Khojasteh, Hoda; Heidari, Mansour

    2016-06-01

    Retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. The objective of this study was to investigate the effects of SD-208, TGF-β-RI kinase inhibitor, on the expression of some miRNAs including a miR-17/92 cluster in retinoblastoma cells. Prior to initiate this work, the cell proliferation was studied by Methyl Thiazolyl Tetrazolium (MTT) and bromo-2'-deoxyuridine (BrdU) assays. Then, the expression patterns of four miRNAs (18a, 20a, 22, and 34a) were investigated in the treated SD-208 (0.0, 1, 2 and 3 µM) and untreated Y-79 cells. A remarkable inhibition of the cell proliferation was found in Y-79 cells treated with SD-208 versus untreated cells. Also, the expression changes were observed in miRNAs 18a, 20a, 22 and 34a in response to SD-208 treatment (P<0.05). The findings of the present study suggest that the anti-cancer effect of SD-208 may be exerted due to the regulation of specific miRNAs, at least in this particular retinoblastoma cell line. To the best of the researchers' knowledge, this is the first report demonstrating that the SD-208 could alter the expression of tumor suppressive miRNAs as well as oncomiRs in vitro. In conclusion, the present data suggest that SD-208 could be an alternative agent in retinoblastoma treatment.

  16. 22 CFR 208.310 - What must I do if a Federal agency excludes a person with whom I am already doing business in a...

    Science.gov (United States)

    2010-04-01

    ... person with whom I am already doing business in a covered transaction? 208.310 Section 208.310 Foreign...) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 208.310 What must I do if a Federal agency excludes a person with whom I am already doing business in a covered...

  17. 22 CFR 208.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-04-01

    ...) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 208.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business? Before entering into... at lower tiers with whom I intend to do business? 208.330 Section 208.330 Foreign Relations...

  18. 8 CFR 208.10 - Failure to appear at an interview before an asylum officer or failure to follow requirements for...

    Science.gov (United States)

    2010-01-01

    ... asylum officer or failure to follow requirements for fingerprint processing. 208.10 Section 208.10 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS PROCEDURES FOR ASYLUM AND WITHHOLDING OF REMOVAL Asylum and Withholding of Removal § 208.10 Failure to appear at an interview before...

  19. 5 CFR 843.208 - Notification of current and/or former spouse before payment of unexpended balance to a separated...

    Science.gov (United States)

    2010-01-01

    ... spouse before payment of unexpended balance to a separated employee. 843.208 Section 843.208... EMPLOYEES RETIREMENT SYSTEM-DEATH BENEFITS AND EMPLOYEE REFUNDS One-time Payments § 843.208 Notification of current and/or former spouse before payment of unexpended balance to a separated employee. (a) Payment...

  20. Clinical Analysis of 208 Patients with Fever of Unknown Origin%发热原因待查208例临床分析

    Institute of Scientific and Technical Information of China (English)

    罗百灵; 张立

    2012-01-01

    目的:分析总结208例发热原因待查(fever of unknown origin,FUO)患者的临床特点,指导临床FOU诊断.方法:回顾性分析208例FUO患者的临床表现、相关辅助检查、诊断经过、诊断性治疗等情况.结果:208例FUO患者最后确诊182例,确诊率为87.5%.182例确诊病例中感染性发热98例(53.8%),其中普通细菌感染51例(52.0%),结核感染36例(36.7%);非感染性发热84例(46.2%),其中风湿病57例(67.9%),恶性肿瘤17例(20.2%).结论:感染性发热仍是临床上发热最常见的原因.结核感染、结缔组织病及造血系统恶性肿瘤所致的发热是FUO常见的原因:一些疑似的结核病可积极进行诊断性治疗,并积极病理组织活检以明确诊断.发热原因待查患者中结缔组织病的比例较前有明显提升,结缔组织病合并感染也可引起高热,需引起足够重视,以免误诊.%Objective: To analyze the clinical features of 208 patients which were fever of unknown origin, in order to guide clinical diagnosis of fever of unknown origin. Methods: Retrospective we analyzed for the clinical manifestations, auxiliary examination, diagnostic treatment and process, etc. Result: In the 208 patients, there were 182 patients were diagnosis definitely, the diagnostic rate is 87.5%. Hi these confirmed cases, 98 patients were infectious fever (53.8%).In these infectious fever patients, there were common bacterial infection in 51 cases (52.0%), tuberculosis infection in 36 cases (36.7%); Non-infectious fever in 84 cases (46.2%), including 57 cases of Connective tissue disease (67.9%) and 17 cases of malignancy (20.2%). Conclusions: Infectious fever is also the most common cause of fever of unknown origin. Tuberculosis infection, fever caused by rheumatic diseases and hematopoietic malignancies are common cause of FOU. In order to diagnosis definitely, Some of the suspected TB can be positive diagnostic treatment and do pathologic biopsy, hi the patients of

  1. MicroRNA deep sequencing reveals chamber-specific miR-208 family expression patterns in the human heart.

    Science.gov (United States)

    Kakimoto, Yu; Tanaka, Masayuki; Kamiguchi, Hiroshi; Hayashi, Hideki; Ochiai, Eriko; Osawa, Motoki

    2016-05-15

    Heart chamber-specific mRNA expression patterns have been extensively studied, and dynamic changes have been reported in many cardiovascular diseases. MicroRNAs (miRNAs) are also important regulators of normal cardiac development and functions that generally suppress gene expression at the posttranscriptional level. Recent focus has been placed on circulating miRNAs as potential biomarkers for cardiac disorders. However, miRNA expression levels in human normal hearts have not been thoroughly studied, and chamber-specific miRNA expression signatures in particular remain unclear. We performed miRNA deep sequencing on human paired left atria (LA) and ventricles (LV) under normal physiologic conditions. Among 438 miRNAs, miR-1 was the most abundant in both chambers, representing 21% of the miRNAs in LA and 26% in LV. A total of 25 miRNAs were differentially expressed between LA and LV; 14 were upregulated in LA, and 11 were highly expressed in LV. Notably, the miR-208 family in particular showed prominent chamber specificity; miR-208a-3p and miR-208a-5p were abundant in LA, whereas miR-208b-3p and miR-208b-5p were preferentially expressed in LV. Subsequent real-time polymerase chain reaction analysis validated the predominant expression of miR-208a in LA and miR-208b in LV. Human atrial and ventricular tissues display characteristic miRNA expression signatures under physiological conditions. Notably, miR-208a and miR-208b show significant chamber-specificity as do their host genes, α-MHC and β-MHC, which are mainly expressed in the atria and ventricles, respectively. These findings might also serve to enhance our understanding of cardiac miRNAs and various heart diseases. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping, E-mail: bieping2010@163.com

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  3. Gamow-Teller and dipole strength in the {sup 208}Pb(n,p) reaction

    Energy Technology Data Exchange (ETDEWEB)

    Raywood, K.J.; Long, S.A.; Spicer, B.M.

    1997-06-01

    Earlier date on the {sup 208}Pb(n.p){sup 208}Tl reaction at 198 MeV has been analysed using the multipole decomposition technique, and the contributions tot he spectra from L=0 and 1 transitions determined. The L=0 cross section has been found to be smaller than values given by the calculations of Macfarlane for Gamow-Teller transitions, using three different forms for the population of single particle states about the Fermi energy. Comparison is made with GT-strength values obtained from a more recent mean field calculation of these populations, and with an older nuclear structure calculation of properties of the lead nuclei. the L=1 strength distribution is also reported. 13 refs., 4 figs.

  4. All-Solid-State Multi-wavelength Laser System from 208 to 830 nm

    Institute of Scientific and Technical Information of China (English)

    ZHAO Shang-Hong; CHEN Guo-Fu; ZHAO Wei; WANG Yi-Shan; YU Lian-Jun

    2001-01-01

    Four-wavelength lasers from the near-infrared to deep-ultraviolet range, 532, 830, 415 and 208nm, have been developed in one all-solid-state laser system. The laser system is pumped by a diode-Q-YLF laser at 532nm,a Ti:sapphire laser, and the nonlinear second-harmonic-generation crystals LBO and BBO are used to generate different wavelengths. Maximum average powers (repetition rate 1 kHz) of 1.1 W at 830nm, 380m W at 415nm and 39mW at 208nm are obtained when the pumping power is 3.6 W. The main characteristics of this system are presented.

  5. Coulomb excitation of re-accelerated 208Rn and 206Po beams

    Directory of Open Access Journals (Sweden)

    Grahn T.

    2013-12-01

    Full Text Available In the present study, B(E2; 2+ → 0+ values have been measured in the 208Rn and 206Po nuclei through Coulomb excitation of re-accelerated radioactive beams in inverse kinematics at CERN-ISOLDE. The resulting B(E2; 2+ → 0+ in 208Rn is ∼ 0.08 e2b2. These nuclei lie in, or at the boundary of the region where seniority scheme should persist. However, contributions from collective excitations may be present when moving away from the N = 126 shell closure. To date, surprisingly little is known of the transition probabilities between the low-spin states in this region.

  6. Measurement of the 208Pb(52Cr, n)259Sg Excitation Function

    Energy Technology Data Exchange (ETDEWEB)

    Folden III, C.M.; Dragojevic, I.; Dullmann, Ch.E.; Eichler, R.; Garcia, M.A.; Gates, J.M.; Nelson, S.L.; Sudowe, R.; Gregorich, K.E.; Hoffman, D.C.; Nitsche, H.

    2010-03-19

    The excitation function for the 208Pb(52Cr, n)259Sg reaction has been measured using the Berkeley Gas-filled Separator at the Lawrence Berkeley National Laboratory 88-Inch Cyclotron. The maximum cross section of pb is observed at a center-of-target laboratory-frame energy of 253.0 MeV. In total, 25 decay chains originating from 259Sg were observed and the measured decay properties are in good agreement with previous reports. In addition, a partial excitation function for the 208Pb(52Cr, 2n)258Sg reaction was obtained, and an improved 258Sg half-life of ms was calculated by combining all available experimental data.

  7. Self-consistent Hartree-Fock RPA calculations in 208Pb

    Science.gov (United States)

    Taqi, Ali H.; Ali, Mohammed S.

    2017-07-01

    The nuclear structure of 208Pb is studied in the framework of the self-consistent random phase approximation (SCRPA). The Hartree-Fock mean field and single particle states are used to implement a completely SCRPA with Skyrme-type interactions. The Hamiltonian is diagonalised within a model space using five Skyrme parameter sets, namely LNS, SkI3, SkO, SkP and SLy4. In view of the huge number of the existing Skyrme-force parameterizations, the question remains which of them provide the best description of data. The approach attempts to accurately describe the structure of the spherical even-even nucleus 208Pb. To illustrate our approach, we compared the binding energy, charge density distribution, excitation energy levels scheme with the available experimental data. Moreover, we calculated isoscalar and isovector monopole, dipole, and quadrupole transition densities and strength functions.

  8. Scattering of {sup 8}He on {sup 208}Pb at 22 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Marquinez-Duran, G.; Sanchez-Benitez, A. M.; Martel, I.; Berjillos, R.; Duenas, J. A.; Parkar, V. V. [Depto. de Fisica Aplicada, Universidad de Huelva, 21071 Huelva (Spain); Acosta, L. [Depto. de Fisica Aplicada, Universidad de Huelva, 21071 Huelva, Spain and Laboratori Nazionali del Sud, INFN, Via Santa Sofia 62, 95123, Catania (Italy); Rusek, K. [Heavy Ion Laboratory, University of Warsaw (Poland); Alvarez, M. A. G.; Gomez-Camacho, J. [Centro Nacional de Aceleradores, 41092, Sevilla, Spain and Depto. de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, 41080 Sevilla (Spain); Borge, M. J. G.; Cruz, C.; Cubero, M.; Pesudo, V.; Tengblad, O. [Instituto de Estructura de la Materia, CSIC, 28006 Madrid (Spain); Chbihi, A. [GANIL, CEA and IN2P3-CNRS, B.P. 5027, 14076 Caen cedex (France); Fernandez-Garcia, J. P.; Moro, A. M. [Depto. de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, 41080 Sevilla (Spain); Fernandez-Martinez, B.; Labrador, J. A. [Centro Nacional de Aceleradores, 41092, Sevilla (Spain); and others

    2013-06-10

    The skin nucleus {sup 8}He is investigated by measuring the angular distribution of the elasticly scattered {sup 8}He and the {sup 6,4}He fragments produced in the collision with a {sup 208}Pb target at 22 MeV, just above the Coulomb barrier. The experiment was carried out at SPIRAL/GANIL in 2010. Here we present preliminary results for the elastic scattering.

  9. Influence of Shell on Pre-scission Particle Emission of a Doubly Magic Nucleus 208Pb

    Institute of Scientific and Technical Information of China (English)

    YE Wei

    2004-01-01

    Using Smoluchowski equation, we study the shell effects on the emission of light particles in the fission process of a doubly magic nucleus 208 pb. Calculated results show that shell has a considerable effect on the neutron emission and that shell effect gradually becomes weak with increasing excitation energy. In addition, a dependence of shell effects in the neutron emission on the angular momentum has been found.

  10. Complete identification of states in 208Pb below Ex=6.2 MeV

    Science.gov (United States)

    Heusler, A.; Jolos, R. V.; Faestermann, T.; Hertenberger, R.; Wirth, H.-F.; von Brentano, P.

    2016-05-01

    The Q3D magnetic spectrograph at the Maier-Leibnitz-Laboratorium of the Ludwig-Maximilians-Universität München and the Technische Universität München (Garching, Germany), was used to study the 208Pb(p ,p' ) , 206,207,208Pb (d,p), and 208Pb(d ,d' ) reactions. One hundred fifty-one states at Ex<6.20 MeV in 208Pb are identified and spin and parity assigned. Four states are newly identified and new spins and/or parities are assigned to 25 states. Tentative spin assignments are done to five states at 5.90

  11. Complete Electric and Magnetic Dipole Response of 208Pb from Zero-Degree Inelastic Proton Scattering

    Science.gov (United States)

    von Neumann-Cosel, P.

    2015-11-01

    Small-angle polarized proton scattering including 0° off 208Pb has been studied at the RCNP cyclotron with high energy resolution of the order of 25 keV (FWHM). The complete E1 strength distribution from 5 to 20 MeV could be extracted from the data and is found to agree well with available data. New E1 strength is found in the energy region above threshold inacessible in previous experiments. The total E1 polarizability as well as the properties of the pygmy dipole resonance could be determined with high precision providing important experimental constraints on the neutron skin thickness in 208Pb and the symmetry energy of neutron-rich matter. Additionally, information on the spin-M1 strength in 208Pb was obtained. Assuming dominance of the central spin-isospinflip part of the effective proton-nucleus interaction, the B(M1) transition strength can be derived. It corresponds well with data from electromagnetic probes indicating that the reaction can provide information on the poorly known spin-M1 resonance in heavy nuclei.

  12. The use of TI-208 gamma rays for safeguards, nondestructive-assay (NDA) measurements

    Energy Technology Data Exchange (ETDEWEB)

    Oberer, R. B.; Chiang, L. G.; Norris, M. J.; Gunn, C. A.; Adaline, B. C.

    2009-05-26

    This paper examines two cases where gamma rays from Tl-208, including the 2614keV gamma ray, were used to detect anomalies in waste material. In addition to the characterization of waste for waste acceptance, and compliance with environmental and transportation laws, there is a safeguards element as well. The more sophisticated method of NDA at Y-12 includes a means to detect shielded special nuclear material (SNM). Excess count rates in the 2614keV gamma ray from Tl-208 are an indication of potential shielded HEU in waste as well as other containers. The 2614keV gamma ray is easy to monitor routinely. When a large 2614keV peak is detected, further investigation can be conducted from the gamma spectrum. This paper describes this further investigation in two cases. In one case self-shielded HEU was detected. In the other case the Tl-208 gamma rays came from a piece of Th-232 metal.

  13. Symmetry energy at subsaturation densities and the neutron skin thickness of 208Pb

    CERN Document Server

    Fan, Xiaohua; Zuo, Wei

    2015-01-01

    The mass-dependent symmetry energy coefficients $a_{sym}(A)$ has been extracted by analysing the heavy nuclear mass differences reducing the uncertainties as far as possible in our previous work. Taking advantage of the obtained symmetry energy coefficient $a_{sym}(A)$ and the density profiles obtained by switching off the Coulomb interaction in $^{208}\\text{Pb}$, we calculated the slope parameter $L_{0.11}$ of the symmetry energy at the density of $0.11\\text{fm}^{-3}$. The calculated $L_{0.11}$ ranges from 40.5 MeV to 60.3 MeV. The slope parameter $L_{0.11}$ of the symmetry energy at the density of $0.11\\text{fm}^{-3}$ is also calculated directly with Skyrme interactions for nuclear matter and is found to have a fine linear relation with the neutron skin thickness of $^{208}\\text{Pb}$, which is the difference of the neutron and proton rms radii of the nucleus. With the linear relation the neutron skin thickness $ \\Delta R_{np} $ of $^{208}\\text{Pb}$ is predicted to be 0.15 - 0.21 fm.

  14. Neutron skin of (208)Pb, nuclear symmetry energy, and the parity radius experiment.

    Science.gov (United States)

    Roca-Maza, X; Centelles, M; Viñas, X; Warda, M

    2011-06-24

    A precise determination of the neutron skin Δr(np) of a heavy nucleus sets a basic constraint on the nuclear symmetry energy (Δr(np) is the difference of the neutron and proton rms radii of the nucleus). The parity radius experiment (PREX) may achieve it by electroweak parity-violating electron scattering (PVES) on (208)Pb. We investigate PVES in nuclear mean field approach to allow the accurate extraction of Δr(np) of (208)Pb from the parity-violating asymmetry A(PV) probed in the experiment. We demonstrate a high linear correlation between A(PV) and Δr(np) in successful mean field forces as the best means to constrain the neutron skin of (208)Pb from PREX, without assumptions on the neutron density shape. Continuation of the experiment with higher precision in A(PV) is motivated since the present method can support it to constrain the density slope of the nuclear symmetry energy to new accuracy.

  15. The First Outbreak Caused by Acinetobacter baumannii ST208 and ST195 in China

    Directory of Open Access Journals (Sweden)

    Junyan Qu

    2016-01-01

    Full Text Available This study aimed to analyze the clinical characteristics of patients and molecular mechanisms of the first outbreak mainly caused by sequence types (STs 208 multidrug resistant (MDR Acinetobacter baumannii in China. A total of 10 clinical samples were collected from 5 patients who were involved in the outbreak. Bacterial identification and antibiotic sensitivity tests were performed by the VITEK-2 COMPACT automated system. MICs of tigecycline for clinical isolates were determined using broth microdilution. The clonal relatedness of A. baumannii clinical isolates in our local settings was determinated by pulsed-field gel electrophoresis (PFGE and multilocus sequence typing (MLST. A total of 7 A. baumannii strains were isolated and all were MDR strains; two of them were carbapenem-nonsusceptible strains. blaOXA-23 was the only acquired carbapenemase gene in the isolates. The isolates belonged to a single clonal pulsotype determined by PFGE and two sequences types (STs determined by MLST. The isolates belonged to the globally disseminated clonal complex 92, among which ST195 and ST208 were the most common sequence types (71.43% and 28.57%. The outbreak was successfully controlled by stringent infection control measures, especially improving the hand hygiene compliance and enhancing antimicrobial stewardship. In conclusion, this is the first description of an outbreak caused mainly by A. baumannii of ST208 in China. Infection control measures should be strengthened when infection outbreaks in hospital.

  16. Void effect analysis of Pb-208 of fast reactors with modified CANDLE burn-up scheme

    Science.gov (United States)

    Widiawati, Nina; Su'ud, Zaki

    2015-09-01

    Void effect analysis of Pb-208 as coolant of fast reactors with modified candle burn-up scheme has been conducted. Lead cooled fast reactor (LFR) is one of the fourth-generation reactor designs. The reactor is designed with a thermal power output of 500 MWt. Modified CANDLE burn-up scheme allows the reactor to have long life operation by supplying only natural uranium as fuel cycle input. This scheme introducing discrete region, the fuel is initially put in region 1, after one cycle of 10 years of burn up it is shifted to region 2 and region 1 is filled by fresh natural uranium fuel. The reactor is designed for 100 years with 10 regions arranged axially. The results of neutronic calculation showed that the void coefficients ranged from -0.6695443 % at BOC to -0.5273626 % at EOC for 500 MWt reactor. The void coefficients of Pb-208 more negative than Pb-nat. The results showed that the reactors with Pb-208 coolant have better level of safety than Pb-nat.

  17. Effect of proteases on biofilm formation of the plastic-degrading actinomycete Rhodococcus ruber C208.

    Science.gov (United States)

    Gilan, Irit; Sivan, Alex

    2013-05-01

    In most habitats, the vast majority of microbial populations form biofilms on solid surfaces, whether natural or artificial. These biofilms provide either increased physical support and/or a source of nutrients. Further modifications and development of biofilms are regulated by signal molecules secreted by the cells. Because synthetic polymers are not soluble in aqueous solutions, biofilm-producing bacteria may biodegrade such materials more efficiently than planktonic strains. Bacterial biofilms comprise bacterial cells embedded in self-secreted extracellular polymeric substances (EPS). Revealing the roles of each component of the EPS will enable further insight into biofilm development and the EPS structure-function relationship. A strain of Rhodococcus ruber (C208) displayed high hydrophobicity and formed a dense biofilm on the surface of polyethylene films while utilizing the polyolefin as carbon and energy sources. This study investigated the effects of several proteases on C208 biofilm formation and stability. The proteolysis of C208 biofilm gave conflicting results. Trypsin significantly reduced biofilm formation, and the resultant biofilm appeared monolayered. In contrast, proteinase K enhanced biofilm formation, which was robust and multilayered. Presumably, proteinase K degraded self-secreted proteases or quorum-sensing peptides, which may be involved in biofilm detachment processes, leading to a multilayered, nondispersed biofilm.

  18. Safety Analysis of Pb-208 Cooled 800 MWt Modified CANDLE Reactors

    Science.gov (United States)

    Su'ud, Zaki; Widiawati, Nina; Sekimoto, H.; Artoto, A.

    2017-01-01

    Safely analysis of 800MWt Pb-208 cooled fast reactors with natural Uranium as fuel cycle input employing axial-radial combined Modiified CANDLE burnup scheme has been performed. The analysis of unprotected loss of flow(ULOF) and unprotected rod run-out transient overpower (UTOP) are discussed. Some simulations for 800 MWt Pb-208 cooled fast reactors has been performed and the results show that the reactor can anticipate complete pumping failure inherently by reducing power through reactivity feedback and remove the rest of heat through natural circulations. Compared to the Pb-nat cooled long life Fast Reactors, Pb-208 cooled reactors have smaller Doppler but higher coolant density reactivity coefficient. In the UTOP accident case the analysis has been performed against external reactivity up to 0.003dk/k. And for ULOHS case it is assumed that the secondary cooling system has broken. During all accident the cladding temperature is the most critical. Especially for the case of UTOP accident. In addition the steam generator design has also consider excess power which may reach 50% extra during severe UTOP case..

  19. Analysis on the Rehabilitation Demand of 208 Lushan Earthquake Victims%208例芦山地震伤员康复需求分析

    Institute of Scientific and Technical Information of China (English)

    刘思佳; 谢薇; 何成奇; 屈云; 李莎莎

    2013-01-01

    目的 调查并分析芦山地震伤员的创伤类型、功能受限情况,以及伤员的康复需求.方法 采用地震伤员康复需求调查表调查四川大学华西医院收治的208例芦山地震伤员的康复需求.结果 208例被调查伤员的创伤类型以骨折居首(138例),其次为复合伤、软组织损伤、肺挫伤和截肢.绝大部分伤员的运动功能、平衡功能、日常生活活动能力出现障碍,80%以上患者出现疼痛,少部分人出现感觉异常、呼吸障碍.大量患者需要康复辅具及住院治疗.结论 芦山地震伤员的创伤类型及功能受限情况决定了患者所需康复辅具,结合伤员对康复的要求,可为伤员“量身定制”康复治疗方案.康复医学的早期介入极有益于地震伤员的康复.%Objective To investigate the injury types,dysfunction situation and rehabilitation deamnd of the Lushan earthquake victims.Methods The rehabilitation demand of 208 Lushan earthquake victims in the West China Hospital of Sichuan University were investigated using a questionnaire.Results Bone fractures accounted for the largest proportion of injury types,followed by combined injuries,soft tissue injuries,pulmonary contusion,and amputation.Most victims suffered from the motor dysfunction,balance disorder and restrictions in activities of daily living.More than 80% of victims had pain.A few victims had paresthesia and respiratory disorder.Most victims needed rehabilitation assistant devices and hospitalization treatment.Conclusion The injury types and dysfunction situation of Lushan earthquake victims are associated with the demand of rehabilitation assistant device.The tailored rehabilitation regimen can be made in combination with victim's rehabilitation demand.The early intervention of rehabilitation medicine is extremely beneficial to the recovery of earthquake victims.

  20. A consistent four-body CDCC model of low-energy reactions: Application to 9Be + 208Pb

    CERN Document Server

    Hussein, M S; Canto, L F

    2015-01-01

    We investigate the $^9$Be + $^{208}$Pb elastic scattering, breakup and fusion at energies around the Coulomb barrier. The three processes are described simultaneously, with identical conditions of calculations. The $^{9}$Be nucleus is defined in an $\\alpha + \\alpha$ + n three-body model, using the hyperspherical coordinate method. We first analyze spectroscopic properties of $^9$Be, and show that the model provides a fairly good description of the low-lying states. The scattering with $^{208}$Pb is then studied with the Continuum Discretized Coupled Channel (CDCC) method, where the $\\alpha+\\alpha$ + n continuum is approximated by a discrete number of pseudostates. Optical potentials for the $\\alpha$+ $^{208}$Pb and n+ $^{208}$Pb systems are taken from the literature. We present elastic-scattering and fusion cross sections at different energies.

  1. A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.

    Science.gov (United States)

    Jahagirdar, Ravi; Zhang, Haiyan; Azhar, Salman; Tobin, Jennifer; Attwell, Sarah; Yu, Raymond; Wu, Jin; McLure, Kevin G; Hansen, Henrik C; Wagner, Gregory S; Young, Peter R; Srivastava, Rai Ajit K; Wong, Norman C W; Johansson, Jan

    2014-09-01

    Despite the benefit of statins in reducing cardiovascular risk, a sizable proportion of patients still remain at risk. Since HDL reduces CVD risk through a process that involves formation of pre-beta particles that facilitates the removal of cholesterol from the lipid-laden macrophages in the arteries, inducing pre-beta particles, may reduce the risk of CVD. A novel BET bromodomain antagonist, RVX-208, was reported to raise apoA-I and increase preβ-HDL particles in non-human primates and humans. In the present study, we investigated the effect of RVX-208 on aortic lesion formation in hyperlipidemic apoE(-/-) mice. Oral treatments of apoE(-/-) mice with 150 mg/kg b.i.d RVX-208 for 12 weeks significantly reduced aortic lesion formation, accompanied by 2-fold increases in the levels of circulating HDL-C, and ∼50% decreases in LDL-C, although no significant changes in plasma apoA-I were observed. Circulating adhesion molecules as well as cytokines also showed significant reduction. Haptoglobin, a proinflammatory protein, known to bind with HDL/apoA-I, decreased >2.5-fold in the RVX-208 treated group. With a therapeutic dosing regimen in which mice were fed Western diet for 10 weeks to develop lesions followed by switching to a low fat diet and concurrent treatment with RVX-208 for 14 weeks, RVX-208 similarly reduced lesion formation by 39% in the whole aorta without significant changes in the plasma lipid parameters. RVX-208 significantly reduced the proinflammatory cytokines IP-10, MIP1(®) and MDC. These results show that the antiatherogenic activity of BET inhibitor, RVX-208, occurs via a combination of lipid changes and anti-inflammatory activities.

  2. SOME RECENT RESULTS ON NEUTRON DECAY OF PB-208 EXCITED TO ENERGIES IN THE 14 TO 25 MEV RANGE

    NARCIS (Netherlands)

    CHMIELEWSKA, D; VANDENBERG, AM; BLUMENFELD, Y; ALAMANOS, N; AUGER, F; BLOMGREN, J; BORDEWIJK, J; BRANDENBURG, S; FRASCARIA, N; GILLIBERT, A; NILSSON, L; OLSSON, N; ROUSSELCHOMAZ, P; ROYNETTE, JC; SCARPACI, JA; SUOMIJARVI, T; TURCOTTE, R; VANDERWOUDE, A; van der Woude, Adriaan

    1994-01-01

    First results of an (Pb(O, O'n)Pb)-Pb-208-O-17-O-17-Pb-207 experiment at 84 MeV/n, designed to study the neutron decay of the Giant Dipole Resonance and the region above, is presented. Direct decay up to an excitation energy of 25 MeV in Pb-208 has been observed. The direct decay branch in the GDR e

  3. 208例手足口病临床分析%Analysis of 208 Cases of Hand Foot and Mouth Disease

    Institute of Scientific and Technical Information of China (English)

    肖敏

    2014-01-01

    目的分析我院手足口病的临床特点、治疗方法及预防措施。方法采集我院2008年5月~2011年12月住院的手足口病患儿208例进行临床分析。结果手足口病多发于<3岁儿童,多发生于5~7月份,临床以手、足、口、臀等部位皮肤、粘膜的斑丘疹或疱疹为主要特征。所有病例均治愈出院。结论手足口病大多临床表现症状轻,预后良好。少数患儿病情进展快,出现重症病例。早发现、早诊断、早隔离、早治疗是防治手足口病的关键。%Objective Clinical characteristics, treatment and prevention of hand foot and mouth disease. Methods Col ected from May to 2011 December in our hospital in 2008 HFMD patients clinical analysis of 208 cases. Results Foot and mouth disease often occurred in children under 3 years old, occurs in 5 to July, clinical by the hand, foot, mouth, but ocks and other parts of skin, mucous membrane spot papula or herpes as the main feature. Al patients were cured and discharged. Conclusion Hand foot and mouth disease are symptoms of light, the prognosis is good. A few children with the disease progress quickly, severe cases. Early discovery, early diagnosis, early isolation, early treatment is the key to prevention of hand foot and mouth disease.

  4. Dynamical Cluster-decay Model (DCM) applied to 9Li+208Pb reaction

    Science.gov (United States)

    Kaur, Arshdeep; Hemdeep; Kaushal, Pooja; Behera, Bivash R.; Gupta, Raj K.

    2017-10-01

    The decay mechanism of 217At* formed in 9Li+208Pb reaction is studied within the dynamical cluster-decay model (DCM) at various center-of-mass energies. The aim is to see the behavior of a light neutron-rich radioactive beam on a doubly-magic target nucleus for the (total) fusion cross section σfus and the individual decay channel cross sections. Experimentally, only the isotopic yield of heavy mass residues 211-214At * [equivalently, the light-particles (LPs) evaporation residue cross sections σxn for x = 3- 6 neutrons emission] are measured, with the fusion-fission (ff) component σff taken zero. For a fixed neck-length parameter ΔR, the only parameter in the DCM, we are able to fit σfus =∑x=16σxn almost exactly for 9Li on 208Pb at all E c . m .'s. However, the observed individual decay channels (3n-6n) are very poorly fitted, with unobserved channels (1n, 2n) and σff strongly over-estimated. Different ΔR values, meaning thereby different reaction time scales, are required to fit individually both the observed and unobserved evaporation residue channels (1n-6n) and σff, but then the compound nucleus (CN) contribution σCN is very small (< 1%), and the non-compound nucleus (nCN) decay cross section σnCN contributes the most towards total σfus (=σCN +σnCN). Thus, the 9Li induced reaction on doubly-magic 208Pb is more of a quasi-fission-like nCN decay, which is further analyzed in terms of the statistical CN formation probability PCN and CN survival probability Psurv. For the reaction under study, PCN < < 1 and Psurv → 1, in particular at above barrier energies.

  5. Surface Diffuseness Anomaly in 16O+208pb Quasi-elastic Scattering at Backward Angle

    Institute of Scientific and Technical Information of China (English)

    JIA Hui-Ming; XU Xin-Xing; BAI Chun-Lin; YU Ning; LIN Cheng-Jian; ZHANG Huan-Qiao; LIU Zu-Hua; YANG Feng; JIA Fei; ZHANG Chun-Lei; AN Guang-Peng; WU Zhen-Dong

    2008-01-01

    @@ The quasi-elastic scattering excitation function of the doubly magic 16O+208pb system at a backward angle is measured at sub-barrier energies with high precision. The diffuseness parameters extracted from both the single-channel and the coupled-channels calculations give almost the same value α = 0.76±0.04 fm. The results show that the coupling effect is negligible for the spherical system. The obtained value is smaller than the extracted value from the fusion excitation function, but larger than the value of α = 0.63 fm, which is from the systematic analysis of elastic scattering data.

  6. Excitation of Giant Monopole Resonance in $^{208}$Pb and $^{116}$Sn Using Inelastic Deuteron Scattering

    CERN Document Server

    Patel, D; Itoh, M; Akimune, H; Berg, G P A; Fujiwara, M; Harakeh, M N; Iwamoto, C; Kawabata, T; Kawase, K; Matta, J T; Murakami, T; Okamoto, A; Sako, T; Schlax, K W; Takahashi, K; White, M; Yosoi, M

    2014-01-01

    The excitation of the isoscalar giant monopole resonance (ISGMR) in $^{116}$Sn and $^{208}$Pb has been investigated using small-angle (including $0^\\circ$) inelastic scattering of 100 MeV/u deuteron and multipole-decomposition analysis (MDA). The extracted strength distributions agree well with those from inelastic scattering of 100 MeV/u $\\alpha$ particles. These measurements establish deuteron inelastic scattering at E$_d \\sim$ 100 MeV/u as a suitable probe for extraction of the ISGMR strength with MDA, making feasible the investigation of this resonance in radioactive isotopes in inverse kinematics.

  7. Effect of Tensor Correlations on Gamow-Teller States in 90Zr and 208Pb

    CERN Document Server

    Bai, C L; Zhang, H Q; Zhang, X Z; Colò, G; Xu, F R

    2008-01-01

    The tensor terms of the Skyrme effective interaction are included in the self-consistent Hartree-Fock plus Random Phase Approximation (HF+RPA) model. The Gamow-Teller (GT) strength function of 90Zr and 208Pb are calculated with and without the tensor terms. The main peaks are moved downwards by about 2 MeV when including the tensor contribution. About 10% of the non-energy weighted sum rule is shifted to the excitation energy region above 30 MeV by the RPA tensor correlations. The contribution of the tensor terms to the energy weighted sum rule is given analytically, and compared to the outcome of RPA.

  8. Study of the cross section determination with the PRISMA spectrometer: The 40Ar + 208Pb case

    Science.gov (United States)

    Mijatović, T.; Szilner, S.; Corradi, L.; Montanari, D.; Pollarolo, G.; Fioretto, E.; Gadea, A.; Goasduff, A.; Jelavić Malenica, D.; Mărginean, N.; Montagnoli, G.; Scarlassara, F.; Soić, N.; Stefanini, A. M.; Ur, C. A.; Valiente-Dobón, J. J.

    2016-04-01

    The PRISMA spectrometer's response function was successfully applied to match three angular and magnetic settings over a wide angular range for measurements of quasi-elastic reactions in 40Ar + 208Pb . The absolute scale of cross sections has been obtained by using the Rutherford cross section at the forward angles and the information from the energy distributions measured with the spectrometer without and with coincidences with the CLARA γ-array. The semi-classical model GRAZING has been used to test the unfolding procedure and for comparison with the corrected cross sections.

  9. Neutron skins of 208Pb and 48Ca from pionic probes

    Science.gov (United States)

    Friedman, E.

    2012-12-01

    The neutron skin of 208Pb has received considerable attention in recent years. A variety of strongly-interacting probes depict a rather consistent picture but pionic probes have not been referred to in this context. We present here neutron-skin values from pionic atoms and from total reaction cross sections of π+ between 0.7 and 2 GeV/c which fit well into the picture. In addition we show that a neutron-skin for 48Ca can be obtained from existing data on pionic atoms and the result agrees with pion scattering experiments and with the scattering of α particles.

  10. The pairing correlation study in the {sup 40}Ar+{sup 208}Pb reaction

    Energy Technology Data Exchange (ETDEWEB)

    Mijatović, T., E-mail: tea.mijatovic@irb.hr; Szilner, S.; Malenica, D. Jelavić; Prepolec, L.; Soić, N.; Tokić, V. [Ruđer Bošković Institute, Zagreb (Croatia); Corradi, L.; Fioretto, E.; Goasduff, A.; Stefanini, A. M.; Dobón, J. J. Valiente [INFN - Laboratori Nazionali di Legnaro, Legnaro (Italy); Montanari, D.; Courtin, S.; Haas, F. [IPHC, CNRS/IN2P3 and Université de Strasbourg, Strasbourg (France); Gadea, A. [IFIC, CSIC-Universidad de Valencia, Valencia (Spain); Montagnoli, G.; Scarlassara, F.; Ur, C. A. [INFN and Università di Padova, Padova (Italy); Pollarolo, G. [INFN and Università di Torino, Torino (Italy)

    2015-10-15

    The multinucleon transfer reaction {sup 40}Ar+{sup 208}Pb has been measured at E{sub lab} = 260 MeV with the large solid angle magnetic spectrometer PRISMA. Mass and charge yields, differential and total cross sections, total kinetic energy loss distributions of different channels were simultaneously studied. Angular distributions were measured in a wide angular range by matching three different angular settings of the spectrometer. Absolute cross sections were obtained after the response function of the spectrometer was evaluated. These cross sections for different transfer channels allow the discussion of the role played by nucleon-nucleon correlations.

  11. Measurement of the Neutron Radius of 208Pb Through Parity-Violation in Electron Scattering

    CERN Document Server

    Abrahamyan, S; Albataineh, H; Aniol, K; Armstrong, D S; Armstrong, W; Averett, T; Babineau, B; Barbieri, A; Bellini, V; Beminiwattha, R; Benesch, J; Benmokhtar, F; Bielarski, T; Boeglin, W; Camsonne, A; Canan, M; Carter, P; Cates, G D; Chen, C; Chen, J -P; Hen, O; Cusanno, F; Dalton, M M; De Leo, R; de Jager, K; Deconinck, W; Decowski, P; Deng, X; Deur, A; Dutta, D; Etile, A; Flay, D; Franklin, G B; Friend, M; Frullani, S; Fuchey, E; Garibaldi, F; Gasser, E; Gilman, R; Giusa, A; Glamazdin, A; Gomez, J; Grames, J; Gu, C; Hansen, O; Hansknecht, J; Higinbotham, D W; Holmes, R S; Holmstrom, T; Horowitz, C J; Hoskins, J; Huang, J; Hyde, C E; Itard, F; Jen, C -M; Jensen, E; Jin, G; Johnston, S; Kelleher, A; Kliakhandler, K; King, P M; Kowalski, S; Kumar, K S; Leacock, J; Leckey, J; Lee, J H; LeRose, J J; Lindgren, R; Liyanage, N; Lubinsky, N; Mammei, J; Mammoliti, F; Margaziotis, D J; Markowitz, P; McCreary, A; McNulty, D; Mercado, L; Meziani, Z -E; Michaels, R W; Mihovilovic, M; Muangma, N; Muñoz-Camacho, C; Nanda, S; Nelyubin, V; Nuruzzaman, N; Oh, Y; Palmer, A; Parno, D; Paschke, K D; Phillips, S K; Poelker, B; Pomatsalyuk, R; Posik, M; Puckett, A J R; Quinn, B; Rakhman, A; Reimer, P E; Riordan, S; Rogan, P; Ron, G; Russo, G; Saenboonruang, K; Saha, A; Sawatzky, B; Shahinyan, A; Silwal, R; Sirca, S; Slifer, K; Solvignon, P; Souder, P A; Sperduto, M L; Subedi, R; Suleiman, R; Sulkosky, V; Sutera, C M; Tobias, W A; Troth, W; Urciuoli, G M; Waidyawansa, B; Wang, D; Wexler, J; Wilson, R; Wojtsekhowski, B; Yan, X; Yao, H; Ye, Y; Ye, Z; Yim, V; Zana, L; Zhan, X; Zhang, J; Zhang, Y; Zheng, X; Zhu, P

    2012-01-01

    We report the first measurement of the parity-violating asymmetry A_PV in the elastic scattering of polarized electrons from 208Pb. A_PV is sensitive to the radius of the neutron distribution (Rn). The result A_PV = 0.656 \\pm 0.060 (stat) \\pm 0.013 (syst) corresponds to a difference between the radii of the neutron and proton distributions Rn - Rp = 0.33 +0.16 -0.18 fm and provides the first electroweak observation of the neutron skin which is expected in a heavy, neutron-rich nucleus.

  12. Evaluation of SD-208, a TGF-β-RI Kinase Inhibitor, as an Anticancer Agent in Retinoblastoma

    Directory of Open Access Journals (Sweden)

    Puran Fadakar

    2016-06-01

    Full Text Available Retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. The objective of this study was to investigate the effects of SD-208, TGF-β-RI kinase inhibitor, on the expression of some miRNAs including a miR-17/92 cluster in retinoblastoma cells. Prior to initiate this work, the cell proliferation was studied by Methyl Thiazolyl Tetrazolium (MTT and bromo-2′-deoxyuridine (BrdU assays. Then, the expression patterns of four miRNAs (18a, 20a, 22, and 34a were investigated in the treated SD-208 (0.0, 1, 2 and 3 µM and untreated Y-79 cells. A remarkable inhibition of the cell proliferation was found in Y-79 cells treated with SD-208 versus untreated cells. Also, the expression changes were observed in miRNAs 18a, 20a, 22 and 34a in response to SD-208 treatment (P<0.05. The findings of the present study suggest that the anti-cancer effect of SD-208 may be exerted due to the regulation of specific miRNAs, at least in this particular retinoblastoma cell line. To the best of the researchers’ knowledge, this is the first report demonstrating that the SD-208 could alter the expression of tumor suppressive miRNAs as well as oncomiRs in vitro. In conclusion, the present data suggest that SD-208 could be an alternative agent in retinoblastoma treatment.

  13. Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p.

    Directory of Open Access Journals (Sweden)

    Chen Bian

    Full Text Available Luteolin (LUT, a kind of flavonoid which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. Recent researches have suggested that LUT can carry out cardioprotective effects during ischemia/reperfusion (I/R. However, there have no reports on whether LUT can exert protective effects against myocardial I/R injury through the actions of specific microRNAs (miRs. The purpose of this study was to determine which miRs and target genes LUT exerted such function through.Expression of various miRs in perfused rat hearts was detected using a gene chip. Target genes were predicted with TargetScan, MiRDB and MiRanda. Anoxia/reoxygenation was used to simulate I/R. Cells were transfected by miR-208b-3p mimic, inhibitor and small interfering RNA of Ets1 (avian erythroblastosis virus E26 (v ets oncogene homolog 1. MiR-208b-3p and Ets1 mRNA were quantified by real-time quantitative polymerase chain reaction. The percentage of apoptotic cells was detected by annexin V-fluorescein isothiocyanate/propidium iodide dyeing and flow cytometry. The protein expression levels of cleaved caspase-3, Bcl-2, Bax, and Ets1 were examined by western blot analysis. A luciferase reporter assay was used to verify the combination between miR-208b-3p and the 3'-untranslated region of Ets1.LUT pretreatment reduced miR-208b-3p expression in myocardial tissue, as compared to the I/R group. And LUT decreased miR-208b-3p expression and apoptosis caused by I/R. However, overexpression of miR-208b-3p further aggravated the changes caused by I/R and blocked all the effects of LUT. Knockdown of miR-208b-3p expression also attenuated apoptosis, while knockdown of Ets1 promoted apoptosis. Further, the luciferase reporter assay showed that miR-208b-3p could inhibit Ets1 expression.LUT pretreatment conveys anti-apoptotic effects after myocardial I/R injury by decreasing miR-208b-3p and increasing Ets1 expression levels.

  14. DNA variation in myoMIRs of the 1, 133, and 208 families in hypertrophic cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Ana I. Corao

    2011-08-01

    Full Text Available MicroRNAs (miRNAs are small RNAs that bind to mRNAs and regulate gene expression. MyoMirs are miRNAs implicated in cardiogenesis. Some MyoMirs have been found deregulated in hearts from patients with left ventricular hypertrophy (LVH. DNA variants at these miRNAs could contribute to the risk of developing hypertrophic cardiomyopathy (HCM. To test this hypothesis we used single strand conformation analysis and direct sequencing to search for DNA variants in the mir-208a, miR-208b, miR-133a-1, miR-133a-2, miR-133b, miR-1-1, and miR-1-2 genes in patients with HCM (n=245, LVH secondary to hypertension (n=120, and healthy controls (n=250. We found several nucleotide variants. Genotyping of patients and healthy controls showed significantly associations between a 133a-1 polymorphism and HCM and a 133b polymorphism and hypertensive- LVH. We concluded that rare variants in these mature miRNAs would be rarely found among HCM patients, but miR-133a-1 and 133b polymorphisms could contribute to the risk of developing cardiac hypertrophy.

  15. The role of doubly magic {sup 208}Pb and its neighbour nuclei in cluster radioactivity

    Energy Technology Data Exchange (ETDEWEB)

    Santhosh, K.P.; Priyanka, B. [Kannur University, School of Pure and Applied Physics, Payyanur (India)

    2013-06-15

    Using the Coulomb and proximity potential model (CPPM) we have investigated the cluster decays of the isotopes {sup 212-240}Pa, {sup 219-245}Np, {sup 228-246}Pu, {sup 230-249}Am and {sup 232-252}Cm leading to doubly magic {sup 208}Pb and its neighboring nuclei, which are not experimentally detected but which may be detectable in the future. It is found that most of the decays are favourable for experimental measurements (i.e., T{sub 1/2}<10{sup 30} s) and this observation will serve as a guide to future experiments. Our study reveals the role of doubly magic {sup 208}Pb daughter nuclei and near doubly magic nuclei in the cluster decay process. In order to make a comparison with CPPM we also calculated the logarithmic half-lives using the Universal formula for the cluster decay (UNIV) by Poenaru et al., the Universal Decay Law (UDL) and the Scaling Law of Horoi et al., and they are found to be in good agreement. The Geiger-Nuttall plots of log{sub 10}(T{sub 1/2}) versus Q{sup -1/2} for various clusters from different isotopes of heavy parent nuclei have been studied and are found to be linear. (orig.)

  16. Lead 207, 208 (n, xn gamma) reactions for neutron energies up to 200 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Pavlik, A.; Vonach, H. [Univ. Wien (Austria). Inst. fuer Radiumforschung und Kernphysik; Chadwick, M.B.; Haight, R.C.; Nelson, R.O.; Wender, S.A.; Young, P.G. [Los Alamos National Lab., NM (United States)

    1994-07-01

    High-resolution {gamma}-ray spectra from the interaction of neutrons in the energy range from 3 to 200 MeV with {sup 207,208}Pb were measured with the white neutron source at the WNR facility at Los Alamos National Laboratory. From these data, excitation functions for prominent {gamma} transitions in {sup 200,202,204,206,207,208}Pb were derived from threshold to 200 MeV incident neutron energy. These {gamma}-production cross sections represent formation cross sections for excited states of the residual nuclei. The results are compared with the predictions of nuclear reaction calculations based on the exciton model for precompound emission, the Hauser-Feshbach theory for compound nuclear decay, and coupled channels calculations to account for direct excitation of collective levels. Good agreement was obtained over the entire energy range covered in the experiment with reasonable model parameters. The results demonstrate that multiple preequilibrium emission has to be taken into account above about 40 MeV, and that the level density model of Ignatyuk should be used instead of the Gilbert-Cameron and back-shifted Fermi-gas models if excitation energies exceed about 30 MeV.

  17. Examination of experimental evidence of chaos in the bound states of 208Pb

    Science.gov (United States)

    Muñoz, L.; Molina, R. A.; Gómez, J. M. G.; Heusler, A.

    2017-01-01

    We study the spectral fluctuations of the 208Pb nucleus using the complete experimental spectrum of 151 states up to excitation energies of 6.20 MeV recently identified at the Maier-Leibnitz Laboratorium at Garching, Germany. For natural parity states the results are very close to the predictions of random matrix theory (RMT) for the nearest-neighbor spacing distribution. A quantitative estimate of the agreement is given by the Brody parameter ω , which takes the value ω =0 for regular systems and ω ≃1 for chaotic systems. We obtain ω =0.85 which is, to our knowledge, the closest value to chaos ever observed in experimental bound states of nuclei. By contrast, the results for unnatural parity states are far from RMT behavior. We interpret these results as a consequence of the strength of the residual interaction in 208Pb, which, according to experimental data, is much stronger for natural than for unnatural parity states. In addition, our results show that chaotic and nonchaotic nuclear states coexist in the same energy region of the spectrum.

  18. Atomic mass measurements of short-lived nuclides around the doubly-magic $^{208}$Pb

    CERN Document Server

    Weber, C; Beck, D; Blaum, K; Bollen, G; Herfurth, F; Kellerbauer, A G; Kluge, H -J; Lunney, D; Schwarz, S

    2008-01-01

    Accurate atomic mass measurements of neutron-deficient and neutron-rich nuclides around the doubly-magic $^{208}$Pb and of neutron-rich cesium isotopes were performed with the Penning trap mass spectrometer ISOLTRAP at ISOLDE/CERN. The masses of $^{145,147}$Cs, $^{181,183}$Tl, $^{186}$Tl$^{m}$, $^{187}$Tl, $^{196}$Tl$^{m}$, $^{205}$Tl, $^{197}$Pb$^{m}$, $^{208}$Pb, $^{190-197}$Bi, $^{209,215,216}$Bi, $^{203,205,229}$Fr, and $^{214,229,230}$Ra were determined. The obtained relative mass uncertainty in the range of $2 \\times 10^{-7}$ to $2 \\times 10^{-8}$ is not only required for safe identification of isomeric states but also allows mapping the detailed structure of the mass surface. A mass adjustment procedure was carried out and the results included into the Atomic Mass Evaluation. The resulting separation energies are discussed and the mass spectrometric and laser spectroscopic data are examined for possible correlations.

  19. Measurement of 208Pb(n ,γ )209Pb Maxwellian averaged neutron capture cross section

    Science.gov (United States)

    Weissman, L.; Tessler, M.; Arenshtam, A.; Eliyahu, I.; Halfon, S.; Guerrero, C.; Kaizer, B.; Kijel, D.; Kreisel, A.; Palchan, T.; Paul, M.; Perry, A.; Schimel, G.; Silverman, I.; Shor, A.; Tamim, N.; Vaintraub, S.

    2017-07-01

    The doubly magic 208Pb nucleus is a bottleneck at the termination of the s -process path due to its very low neutron capture cross section. This cross section is also important for the decomposition of s , r processes and U/Th radiogenic decay contributions to the Pb-Bi solar abundances. The 208Pb(n ,γ )209Pb cross section was measured at the Soreq Applied Research Accelerator Facility Phase I using an intense quasi-Maxwellian neutron source produced by irradiation of the liquid-lithium target with a 1.5-mA continuous-wave proton beam at 1.94 MeV. The cross section was measured by counting the β activity from the irradiated lead target. The measurement allowed us to evaluate the Maxwellian averaged cross section (MACS) at 30 keV obtaining a value of 0.33(2) mb. This has been compared with the earlier activation and time-of-flight measurements found in the literature. The MACS cross-sectional value of the 63Cu(n ,γ )64Cu reaction was determined in the same experiment and is compared to a recent published value.

  20. Freqüência de dermatoses infecciosas em 208 pacientes transplantados renais

    Directory of Open Access Journals (Sweden)

    Vettorato Gérson

    2003-01-01

    Full Text Available FUNDAMENTOS: Nos pacientes transplantados renais, a imunossupressão crônica acarreta maior suscetibilidade às dermatoses infecciosas. OBJETIVOS: avaliar a freqüência de dermatoses infecciosas em 208 pacientes transplantados renais no período de 12 meses e verificar a relação entre sua ocorrência e o período de tempo transcorrido desde o transplante. MÉTODO: 208 transplantados renais de uma população de 720 pacientes foram submetidos a exame dermatológico no período de um ano, tendo sido realizados exames anatomopatológico micológico, bacteriológico e/ou cultural das lesões suspeitas. RESULTADOS: a freqüência de dermatoses infecciosas nessa população foi de 89,4%. As infecções fúngicas, virais, bacterianas e parasitárias mais freqüentes foram pitiríase versicolor (17,8%, verruga vulgar (32,2%, foliculite (4,3% e escabiose (3,8%. CONCLUSÃO: as dermatoses infecciosas são freqüentes nos pacientes transplantados renais, e sua ocorrência aumenta progressivamente conforme o tempo transcorrido a partir do transplante, sendo importante o acompanhamento dermatológico desses pacientes.

  1. Measurement of the Parity Violating Asymmetry in Elastic Electron Scattering off 208Pb

    Energy Technology Data Exchange (ETDEWEB)

    Wexler, Jonathan [Univ. of Massachusetts, Amherst, MA (United States)

    2014-09-01

    The Lead Radius Experiment (PREX) was carried out in order to provide a model-independent measurement of the RMS radius √<$2\\atop{n}$> of the neutron distribution in the 208Pb nucleus. The parity-violating scattering asymmetry for longitudinally polarized 1.06 GeV electrons from an unpolarized 208Pb target was measured at Q2 = 0.00880 GeV2. This measurement was performed by the PREX collaboration in Hall A at Jefferson Laboratory in Newport News, VA, between March and June, 2010. The electron detectors used in this measurement were designed and fabricated by University of Massachusetts-Amherst and Smith College. The resulting parity-violating asymmetry was measured as APV = 656±60(stat.)±14(sys.) ppb. This asymmetry extrapolates to a difference in radii between the nuclear neutron and proton distributions of √<$2\\atop{n}$>-√<$2\\atop{p}$>=0.33$+0.16\\atop{-0.18}$ fm.

  2. P208泵预热油浆管线泄漏原因与对策%The leakage reason and countermeasure of P208 pump oil warm-up pipeline

    Institute of Scientific and Technical Information of China (English)

    王元华; 王家祥; 奚蔚; 秦玉尧; 萧前

    2001-01-01

    The “L”“T” type joints of P208 pump oil warm-up pipeline were scoured by the vortexing,and the evorsion led to crack in weld.The leakage reason and countermeasure were discussed.%分析了炼油装置P208泵预热油浆管线L、T型接头的涡流冲蚀导致焊缝开裂泄漏的原因,提出了工艺结构改进措施。

  3. Collective 2{sup +}{sub 1} excitations in {sup 206}Po and {sup 208,210}Rn

    Energy Technology Data Exchange (ETDEWEB)

    Grahn, T.; Auranen, K.; Herzan, A.; Jakobsson, U.; Julin, R.; Konki, J.; Peura, P.; Rahkila, P.; Stolze, S. [Department of Physics, University of Jyvaskyla (Finland); Helsinki Institute of Physics, Helsinki (Finland); Pakarinen, J. [Department of Physics, University of Jyvaskyla (Finland); Helsinki Institute of Physics, Helsinki (Finland); CERN-ISOLDE, PH Department, CERN, Geneva (Switzerland); Jokiniemi, L.; Suhonen, J. [Department of Physics, University of Jyvaskyla (Finland); Albers, M.; Blazhev, A.; Lewandowski, L.; Moschner, K.; Pfeiffer, M.; Radeck, D.; Reiter, P.; Rudiger, M.; Seidlitz, M.; Siebeck, B.; Steinbach, T.; Thoele, P.; Warr, N.; Vogt, A. [Universitaet zu Koeln, Institut fuer Kernphysik, Koeln (Germany); Bauer, C.; Boenig, S.; Kroell, T.; Thuerauf, M. [TU Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Bernards, C. [Yale University, Wright Nuclear Structure Laboratory, New Haven, CT (United States); Butler, P.A. [University of Liverpool, Department of Physics, Oliver Lodge Laboratory, Liverpool (United Kingdom); Damyanova, A. [Universite de Geneve (Switzerland); Coster, T. de; Witte, H. de; Elseviers, J.; Huyse, M.; Kesteloot, N.; Reynders, K.; Sambi, S.; Wrzosek-Lipska, K. [Department of Physics, Instituut voor Kern- en Stralingsfysica, Leuven (Belgium); Gaffney, L.P. [University of Liverpool, Department of Physics, Oliver Lodge Laboratory, Liverpool (United Kingdom); Department of Physics, Instituut voor Kern- en Stralingsfysica, Leuven (Belgium); University of the West of Scotland, School of Engineering, Paisley (United Kingdom); Rapisarda, E.; Duppen, P. van [Department of Physics, Instituut voor Kern- en Stralingsfysica, Leuven (Belgium); CERN-ISOLDE, PH Department, CERN, Geneva (Switzerland); Salsac, M.D.; Zielinska, M. [CEA-Saclay, Gif-sur-Yvette (France); Scheck, M. [TU Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); University of the West of Scotland, School of Engineering, Paisley (United Kingdom); Venhart, M.; Veselsky, M. [Slovak Academy of Sciences, Institute of Physics, Bratislava 45 (Slovakia); Vermeulen, M.J. [University of York, Department of Physics, York (United Kingdom); Werner, V. [TU Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany); Yale University, Wright Nuclear Structure Laboratory, New Haven, CT (United States)

    2016-11-15

    In the present study, B(E2; 2{sup +}{sub 1} → 0{sup +}{sub 1}) values have been measured in the {sup 208,210}Rn and {sup 206}Po nuclei through Coulomb excitation of re-accelerated radioactive beams in inverse kinematics at CERN-ISOLDE. These nuclei have been proposed to lie in, or at the boundary of the region where the seniority scheme should persist. However, contributions from collective excitations are likely to be present when moving away from the N = 126 closed shell. Such an effect is confirmed by the observed increased collectivity of the 2{sup +}{sub 1} → 0{sup +}{sub 1} transitions. Experimental results have been interpreted with the aid of theoretical studies carried out within the BCS-based QRPA framework. (orig.)

  4. Fragmentation of spin-dipole strength in {sup 90}Zr and {sup 208}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Marketin, T., E-mail: marketin@phy.hr [GSI Helmholtzzentrum fuer Schwerionenforschung, Planckstrasse 1, D-64291 Darmstadt (Germany); Physics Department, Faculty of Science, University of Zagreb, 10000 Zagreb (Croatia); Litvinova, E. [ExtreMe Matter Institute EMMI and Research Division, GSI Helmholtzzentrum fuer Schwerionenforschung, Planckstrasse 1, D-64291 Darmstadt (Germany); Vretenar, D. [Physics Department, Faculty of Science, University of Zagreb, 10000 Zagreb (Croatia); Ring, P. [Physik-Department der Technischen Universitaet Muenchen, D-85748 Garching (Germany)

    2012-01-05

    An extension of time-dependent covariant density functional theory that includes particle-vibration coupling is applied to the charge-exchange channel. Spin-dipole excitation spectra are calculated an compared to available data for {sup 90}Zr and {sup 208}Pb. A significant fragmentation is found for all three angular-momentum components of the spin-dipole strength as a result of particle-vibration coupling, as well as a shift of a portion of the strength to higher energy. A high-energy tail is formed in the strength distribution that linearly decreases with energy. Using a model-independent sum rule, the corresponding neutron skin thickness is estimated and shown to be consistent with values obtained at the mean-field level.

  5. Shell-model calculations in 132Sn and 208Pb regions with low-momentum interactions

    CERN Document Server

    Gargano, A; Covello, A; Itaco, N

    2009-01-01

    We discuss shell-model calculations based on the use of low-momentum interactions derived from the free-space nucleon-nucleon potential. A main feature of this approach is the construction of a smooth potential, V-low-k, defined within a given momentum cutoff. As a practical application of the theoretical framework, we present some selected results of our current study of nuclei around doubly magic 132Sn and 208Pb which have been obtained starting from the CD-Bonn potential. Focusing attention on the similarity between the spectroscopy of these two regions, we show that it emerges quite naturally from our effective interactions without use of any adjustable parameter.

  6. LANDSAT supports data needs for EPA 208 planning. [water quality control and waste treatment management

    Science.gov (United States)

    1979-01-01

    Excerpts from federal legislation and regulations mandating areawide waster treatment management as a means of restoring and maintaining the integrity of the nation's water are presented along with requirements for grants to the states for water quality planning, management, and implementation. Experiences using LANDSAT to identify nonpoint sources of water pollution as well as land/use/land cover features in South Dakota, Kentucky, Georgia, New Jersey, and Texas are described. Present activities suggest that this type of remote sensing is an efficient, effective tool for areawide water quality planning. Interaction with cognizant federal, state, and local government personnel involved in EPA section 208 planning activities can guide the development of new capabilities and enhance their utility and prospect for use.

  7. Random matrix analysis of the monopole strength distribution in $^{208}$Pb

    CERN Document Server

    Severyukhin, A P; Arsenyev, N N; Nazmitdinov, R G; Pichugin, K N

    2016-01-01

    We study statistical properties of the $0^+$ spectrum of $^{208}$Pb in the energy region $E_x\\leq20$ MeV. We use the Skyrme interaction SLy4 as our model Hamiltonian to create a single-particle spectrum and to analyze excited states. The finite-rank separable approximation for the particle-hole interaction enables us to perform the calculations in large configuration spaces. We show that while the position of the monopole resonance centroid is determined by one phonon excitations of $0^+$, the phonon-phonon coupling is crucial for the description of a strength distribution of the $0^+$ spectrum. In fact, this coupling has an impact on the spectral rigidity $\\Delta_3(L)$ which is shifted towards the random matrix limit of the Gaussian orthogonal ensembles.

  8. Challenging nuclear structure models through a microscopic description of proton inelastic scattering off 208Pb

    Science.gov (United States)

    Dupuis, M.; Karataglidis, S.; Bauge, E.; Delaroche, J.-P.; Gogny, D.

    2008-07-01

    Differential cross sections from fully microscopic calculations of inelastic proton scattering off 208Pb are compared to experimental scattering data for incident proton energies between 65 and 201 MeV. The required nucleon-nucleus interactions were formed by folding nuclear structure information with a reliable nucleon-nucleon effective interaction that has no adjustable parameter. The absence of phenomenological normalisation in our approach offers the possibility to interpret with confidence the calculated results in terms of the quality of the underlying nuclear structure description: a feature that had been reserved, until recently, to the electron probe. We have used this method to investigate the effect of long range correlations embedded in excited states on calculated inelastic observables and demonstrate the sensitivity of nucleon scattering predictions to details of the nuclear structure.

  9. Search for resonant nu production at $\\sqrt{s}$ = 183 to 208 GeV

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alderweireld, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Berntzon, L; Bertrand, D; Besançon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Brückman, P; Brunet, J M; Bugge, L; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F R; Chapkin, M M; Charpentier, P; Checchia, P; Chierici, R; Chliapnikov, P V; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, G; Costa, M J; Crawley, B; Crennell, D J; Cuevas-Maestro, J; D'Hondt, J; Da Silva, W; Dalmau, J; De Maria, N; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Min, A; Della Ricca, G; Di Ciaccio, Lucia; Di Simone, A; Doroba, K; Drees, J; Dris, M; Eigen, G; Ekelöf, T J C; Ellert, M; Elsing, M; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Feindt, M; Fernández, J; Ferrer, A; Ferro, F; Flagmeyer, U; Föth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J A; Gandelman, M; García, C; Gavillet, P; Gazis, E N; Geralis, T; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Hansen, J; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Herr, H; Hoffman, J; Holmgren, S O; Holt, P J; Houlden, M A; Hultqvist, K; Jackson, J N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, P D; Johansson, E K; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E C; Kernel, G; Kersevan, Borut P; Kiiskinen, A P; King, B T; Kjaer, N J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kuznetsov, O; Krumshtein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; López, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, M; Mazzucato, F; McNulty, R; Meroni, C; Meyer, W T; Migliore, E; Mitaroff, W A; Mjörnmark, U; Moa, T; Moch, M; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Müller, U; Münich, K; Mulders, M; Mundim, L M; Murray, W; Muryn, B; Myatt, Gerald; Myklebust, T; Nassiakou, M; Navarria, Francesco Luigi; Nawrocki, K; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, Risto; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V F; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Prorok, Dariusz; Pukhaeva, N; Pullia, Antonio; Rames, J; Ramler, L; Read, A; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, R N; Richard, F; Rídky, J; Rivero, M; Rodríguez, D; Romero, A; Ronchese, P; Rosenberg, E I; Roudeau, Patrick; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovskii, A; Salmi, L; Salt, J; Savoy-Navarro, A; Schwickerath, U; Segar, A; Sekulin, R L; Siebel, M; Sissakian, A N; Smadja, G; Smirnova, O G; Sokolov, A; Sopczak, A; Sosnowski, R; Spassoff, Tz; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Timmermans, J; Tkatchev, L G; Tobin, M; Todorovova, S; Tomaradze, A G; Tomé, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M L; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; van Dam, P; Van Eldik, J; Van Lysebetten, A; Van Vulpen, I B; Vegni, G; Veloso, F; Venus, W A; Verbeure, F; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O P; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zimin, N I; Zinchenko, A I; Zupan, M

    2003-01-01

    Searches for resonant nu production in e/sup +/e/sup -/ collisions under the assumption that R-parity is not conserved and that the dominant R-parity violating coupling is lambda /sub 121/or lambda /sub 131/ used data recorded by DELPHI in 1997 to 2000 at centre-of- mass energies of 183 to 208 GeV. No deviation from the standard model was observed. Upper limits are given for the lambda /sub lambda 121/ and lambda /sub 131/ couplings as a function of the sneutrino mass and total width. The limits are especially stringent for sneutrino masses equal to the centre-of-mass energies with the highest integrated luminosities recorded.

  10. Search for deeply bound pionic states in 208Pb via radiative atomic capture of negative pions

    Science.gov (United States)

    Raywood, K. J.; Lange, J. B.; Jones, G.; Pavan, M.; Sevior, M. E.; Hutcheon, D. A.; Olin, A.; Ottewell, D.; Yen, S.; Lee, S. J.; Sim, K. S.; Altman, A.; Friedman, E.; Trudel, A.

    1997-05-01

    A search for narrow, deeply bound pionic atom states via atomic radiative capture of negative pions in a target of 208Pb was carried out for pion kinetic energies of 20 and 25 MeV. Although no clear signature of any such gamma ray emission could be observed in the data, fits of the gamma ray spectra between the energies of 12 and 42 MeV involving a quadratic background together with a pair of peaks (1s, 2p) whose relative intensity was taken from theory yielded an overall strength for the peaks which are consistent (to a 67% confidence level) with radiative capture whose integrated cross section is 20.0 +/- 10.0 μb/sr at 90° for 20 MeV incident pions. A lower probability (40% confidence level) result was obtained when the fit was carried out without the peaks included, just the continuum background.

  11. Collective 2+ 1 excitations in 206Po and 208,210Rn

    Science.gov (United States)

    Grahn, T.; Pakarinen, J.; Jokiniemi, L.; Albers, M.; Auranen, K.; Bauer, C.; Bernards, C.; Blazhev, A.; Butler, P. A.; Bönig, S.; Damyanova, A.; De Coster, T.; De Witte, H.; Elseviers, J.; Gaffney, L. P.; Huyse, M.; Herzáň, A.; Jakobsson, U.; Julin, R.; Kesteloot, N.; Konki, J.; Kröll, Th.; Lewandowski, L.; Moschner, K.; Peura, P.; Pfeiffer, M.; Radeck, D.; Rahkila, P.; Rapisarda, E.; Reiter, P.; Reynders, K.; Rudiger, M.; Salsac, M.-D.; Sambi, S.; Scheck, M.; Seidlitz, M.; Siebeck, B.; Steinbach, T.; Stolze, S.; Suhonen, J.; Thoele, P.; Thürauf, M.; Warr, N.; Van Duppen, P.; Venhart, M.; Vermeulen, M. J.; Werner, V.; Veselsky, M.; Vogt, A.; Wrzosek-Lipska, K.; Zielińska, M.

    2016-11-01

    In the present study, B(E2; 2+1→ 0+1) values have been measured in the 208,210Rn and 206Po nuclei through Coulomb excitation of re-accelerated radioactive beams in inverse kinematics at CERN-ISOLDE. These nuclei have been proposed to lie in, or at the boundary of the region where the seniority scheme should persist. However, contributions from collective excitations are likely to be present when moving away from the N=126 closed shell. Such an effect is confirmed by the observed increased collectivity of the 2+1→ 0+1 transitions. Experimental results have been interpreted with the aid of theoretical studies carried out within the BCS-based QRPA framework.

  12. Monopole giant resonance in $^{100-132}$Sn, $^{144}$Sm and $^{208}$Pb

    CERN Document Server

    Kvasil, J; Repko, A; Reinhard, P -G; Nesterenko, V O; Kleinig, W

    2014-01-01

    The isoscalar giant monopole resonance (GMR) in spherical nuclei $^{100-132}$Sn, $^{144}$Sm, and $^{208}$Pb is investigated within the Skyrme random-phase-approximation (RPA) for a variety of Skyrme forces and different pairing options. The calculated GMR strength functions are directly compared to the available experimental distributions. It is shown that, in accordance to results of other groups, description of GMR in Sn and heavier Sm/Pb nuclei needs different values of the nuclear incompressibilty, $K \\approx$ 200 or 230 MeV, respectively. Thus none from the used Skyrme forces is able to describe GMR in these nuclei simultaneously. The GMR peak energy in open-shell $^{120}$Sn is found to depend on the isoscalar effective mass, which might be partly used for a solution of the above problem. Some important aspects of the problem (discrepancies of available experimental data, proper treatment of the volume and surface compression in finite nuclei, etc) are briefly discussed.

  13. Dynamic adsorption and desorption characteristics of D208 macroporous resin to heparin sodium%D208大孔径树脂对肝素钠动态吸附与解吸特性研究

    Institute of Scientific and Technical Information of China (English)

    葛庆丰; 周雷; 于海; 王捷; 汪志君

    2011-01-01

    Based on preliminary tests, D208 macroporous resin was optimized to extract heparin sodium. Dynamic adsorption and desorption characteristics of D208 macroporous resin for heparin sodium was studied to determine the best process condition for getting most heparin sodium. The results indicated that the best adsorption effect could be obtained at 2 mL · min-1 of adsorption flow rate, 6 mg · mL-1 of sample content and pH 8. 5 condition, and the optimum desorption condition was 5 bed volume 3 mol · L-1 sodium chloride solution as elution solveni, and 1 mL · min-1 of desorption flow rate, and the best desorption effect was achieved.%在前期试验基础上,以优选出的D208大孔径树脂提取、分离肝素钠,通过对D208大孔径树脂不同条件下动态吸附与解吸特性的研究,确定D208大孔径树脂提取、分离肝素钠的最佳工艺条件.结果表明:吸附流速为2 mL· min-1,上样浓度为6 mg·mL-1,上样溶液pH值为8.5,树脂对肝素钠的吸附效果最佳.用5倍柱床体积3 mol·L-1氯化钠溶液为洗脱液,洗脱速度为1 mL· min-1,洗脱效果最佳.

  14. 22 CFR 208.325 - What happens if I do business with an excluded person in a covered transaction?

    Science.gov (United States)

    2010-04-01

    ... Regarding Transactions Doing Business with Other Persons § 208.325 What happens if I do business with an excluded person in a covered transaction? If as a participant you knowingly do business with an excluded... 22 Foreign Relations 1 2010-04-01 2010-04-01 false What happens if I do business with an...

  15. 5 CFR 2640.302 - Waivers issued pursuant to 18 U.S.C. 208(b)(3).

    Science.gov (United States)

    2010-01-01

    ... ETHICS INTERPRETATION, EXEMPTIONS AND WAIVER GUIDANCE CONCERNING 18 U.S.C. 208 (ACTS AFFECTING A PERSONAL.... The agency's determination must be based on a certification that the need for the employee's services... on the committee; (5) The dollar value of the disqualifying financial interest, if it is known or can...

  16. 8 CFR 208.31 - Reasonable fear of persecution or torture determinations involving aliens ordered removed under...

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Reasonable fear of persecution or torture... HOMELAND SECURITY IMMIGRATION REGULATIONS PROCEDURES FOR ASYLUM AND WITHHOLDING OF REMOVAL Credible Fear of Persecution § 208.31 Reasonable fear of persecution or torture determinations involving aliens ordered removed...

  17. 5 CFR 2640.301 - Waivers issued pursuant to 18 U.S.C. 208(b)(1).

    Science.gov (United States)

    2010-01-01

    ... ETHICS INTERPRETATION, EXEMPTIONS AND WAIVER GUIDANCE CONCERNING 18 U.S.C. 208 (ACTS AFFECTING A PERSONAL..., job offer, or enhancement of a spouse's employment); (2) The identity of the person whose financial... employee; (3) The dollar value of the disqualifying financial interest, if it is known or can be...

  18. 12 CFR Appendix B to Part 208 - Capital Adequacy Guidelines for State Member Banks: Tier 1 Leverage Measure

    Science.gov (United States)

    2010-01-01

    ... well above the minimum levels. Moreover, higher capital ratios may be required for any banking... Banks: Tier 1 Leverage Measure B Appendix B to Part 208 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM MEMBERSHIP OF STATE BANKING INSTITUTIONS IN THE...

  19. 33 CFR 208.19 - Marshall Ford Dam and Reservoir (Mansfield Dam and Lake Travis), Colorado River, Tex.

    Science.gov (United States)

    2010-07-01

    ... CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE FLOOD CONTROL REGULATIONS § 208.19... and Reservoir in the interest of flood control as follows: (a) Water Control Plan—(1) General..., flood control, stream regulation, generation of power, irrigation, water supply, and recreation uses....

  20. An investigation of the influence of the pairing correlations on the properties of the isobar analog resonances in = 208 nuclei

    Indian Academy of Sciences (India)

    A Küçükbursa; D I Salamov; T Babacan; H A Aygör

    2004-11-01

    Within the quasi-particle random phase approximation (QRPA), the method of the self-consistent determination of the isovector effective interaction which restores a broken isotopic symmetry for the nuclear part of the Hamiltonian is given. The effect of the pairing correlations between nucleons on the following quantities were investigated for the = 208 nuclei: energies of the isobar analog 0+ states, the isospin admixtures in the ground state of the even–even nuclei, and the differential cross-section for the 208Pb(3He,)208Bi reaction at E(3He) = 450 MeV. Both couplings of the excitation branches with z = 0 ± 1, and the analog state with isovector monopole resonance (IVMR) in the quasi-particle representation were taken into account in our calculations. As a result of these calculations, it was seen that the pairing correlations between nucleons have no considerable effect on the = 23 isospin admixture in the ground state of the 208Pb nucleus, and they cause partially an increase in the isospin impurity of the isobar analog resonance (IAR). It was also established that these correlations have changed the isospin structure of the IAR states, and shifted the energies of the IVMR states to the higher values.

  1. Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes

    DEFF Research Database (Denmark)

    Siebel, Andrew L; Trinh, Si Khiang; Formosa, Melissa F

    2016-01-01

    AIMS: High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I) can modulate glucose metabolism through multiple mechanisms. This study determined the effects of a novel bromodomain and extra-terminal (BET) inhibitor (RVX-208) and putative apoA-I inducer on lipid species contained within HDL...

  2. 11Li Breakup on 208Pb at Energies Around the Coulomb Barrier

    DEFF Research Database (Denmark)

    Fernández-García, J.P.; Cubero, M.; Rodríguez-Gallardo, M.

    2013-01-01

    The inclusive breakup for the 11Li+208Pb reaction at energies around the Coulomb barrier has been measured for the first time. A sizable yield of 9Li following the 11Li dissociation has been observed, even at energies well below the Coulomb barrier. Using the first-order semiclassical perturbatio...

  3. 18 CFR 292.208 - Special requirements for hydroelectric small power production facilities located at a new dam or...

    Science.gov (United States)

    2010-04-01

    ... for hydroelectric small power production facilities located at a new dam or diversion. 292.208 Section... requirements for hydroelectric small power production facilities located at a new dam or diversion. (a) A... means of a new dam or diversion (as that term is defined in § 292.202(p)) is a qualifying facility...

  4. 22 CFR 208.445 - What action may I take if a primary tier participant knowingly does business with an excluded or...

    Science.gov (United States)

    2010-04-01

    ... participant knowingly does business with an excluded or disqualified person? 208.445 Section 208.445 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT... participant knowingly does business with an excluded or disqualified person? If a participant knowingly...

  5. 22 CFR 208.315 - May I use the services of an excluded person as a principal under a covered transaction?

    Science.gov (United States)

    2010-04-01

    ... INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 208.315 May I use the services of an... transaction unless the U.S. Agency for International Development grants an exception under § 208.120....

  6. 31 CFR 585.208 - Prohibited overflights, takeoffs and landings of aircraft en route to or from the FRY (S&M).

    Science.gov (United States)

    2010-07-01

    ... landings of aircraft en route to or from the FRY (S&M). 585.208 Section 585.208 Money and Finance: Treasury..., takeoffs and landings of aircraft en route to or from the FRY (S&M). Except as otherwise authorized, no... off from the territory of the FRY (S&M). See also: Special Federal Aviation Regulation (SFAR) No....

  7. Comprehensive Identification and Bread-Making Quality Evaluation of Common Wheat Somatic Variation Line AS208 on Glutenin Composition.

    Science.gov (United States)

    Liu, Huiyun; Wang, Ke; Xiao, Lele; Wang, Shunli; Du, Lipu; Cao, Xinyou; Zhang, Xiaoxiang; Zhou, Yang; Yan, Yueming; Ye, Xingguo

    2016-01-01

    High molecular weight glutenin subunits (HMW-GSs) are important seed storage proteins in wheat (Triticum aestivum) that determine wheat dough elasticity and processing quality. Clarification of the defined effectiveness of HMW-GSs is very important to breeding efforts aimed at improving wheat quality. To date, there have no report on the expression silencing and quality effects of 1Bx20 and 1By20 at the Glu-B1 locus in wheat. A wheat somatic variation line, AS208, in which both 1Bx20 and 1By20 at Glu-B1 locus were silenced, was developed recently in our laboratory. Evaluation of agronomic traits and seed storage proteins by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and reversed-phase high performance liquid chromatography (RP-HPLC) indicated that AS208 was highly similar to its parental cultivar Lunxuan987 (LX987), with the exception that the composition and expression of HMW-GSs was altered. The 1Bx20 and 1By20 in AS208 were further identified to be missing by polymerase chain reaction (PCR) and quantitative real-time RT-PCR (qRT-PCR) assays. Based on the PCR results for HMW-GS genes and their promoters in AS208 compared with LX987, 1Bx20 and 1By20 were speculated to be deleted in AS208 during in vitro culture. Quality analysis of this line with Mixograph, Farinograph, and Extensograph instruments, as well as analysis of bread-making quality traits, demonstrated that the lack of the genes encoding 1Bx20 and 1By20 caused various negative effects on dough processing and bread-making quality traits, including falling number, dough stability time, mixing tolerance index, crude protein values, wet gluten content, bread size, and internal cell structure. AS208 can potentially be used in the functional dissection of other HMW-GSs as a plant material with desirable genetic background, and in biscuit making industry as a high-quality weak gluten wheat source.

  8. Effect of cadmium on the bioelement composition of Nostoc UAM208: Interaction with calcium

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Pinas, F.; Mateo, P.; Bonilla, I. [Universidad Autonoma de Madrid (Spain)

    1997-04-01

    Heavy metals may cause effects on the cyanobacterial cell including possible damage to the membranes and leakage from cells resulting in the loss or reduction of essential bioelements. There are many reports in the literature concerning morphological, biochemical and physiological changes caused by cadmium in cyanobacteria, but data on the influence of cadmium on the ion balance of the cell dealing with the interactive effect of cadmium and calcium are limited. Calcium has been found to exert a protective role against heavy metal toxicity in a variety of organisms, We previously reported that calcium is able to counteract the toxic effect of cadmium towards growth, photosynthesis, nitrogenase activity and pigment content of the cyanobacterium Nostoc UAM208. In the present study, we analyzed the content of essential ions, as affected by cadmium treatment, to search for possible mechanisms of heavy metal damage and toxicity in Nostoc. We also studied whether calcium enrichment (1.1 mM final concentration) has any influence on the heavy metal effect on those ionic contents. 13 refs., 2 figs.

  9. The $^{136}$Xe + $^{208}$Pb reaction: A test of models of multi-nucleon transfer reactions

    CERN Document Server

    Barrett, J S; Loveland, W; Zhu, S; Ayangeakaa, A D; Carpenter, M P; Greene, J P; Janssens, R V F; Lauritsen, T; McCutchan, E A; Sonzogni, A A; Chiara, C J; Harker, J L; Walters, W B

    2015-01-01

    The yields of over 200 projectile-like fragments (PLFs) and target-like fragments (TLFs) from the interaction of (E$_{c.m.}$=450 MeV) $^{136}$Xe with a thick target of $^{208}$Pb were measured using Gammasphere and off-line $\\gamma$-ray spectroscopy, giving a comprehensive picture of the production cross sections in this reaction.The measured yields were compared to predictions of the GRAZING model and the predictions of Zagrebaev and Greiner using a quantitative metric, the theory evaluation factor, {\\bf tef}. The GRAZING model predictions are adequate for describing the yields of nuclei near the target or projectile but grossly underestimate the yields of all other products. The predictions of Zagrebaev and Greiner correctly describe the magnitude and maxima of the observed TLF transfer cross sections for a wide range of transfers ($\\Delta$Z = -8 to $\\Delta$Z = +2). However for $\\Delta$Z =+4, the observed position of the maximum in the distribution is four neutrons richer than the predicted maximum. The pre...

  10. New high spin states and isomers in the {sup 208}Pb and {sup 207}Pb nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Broda, R.; Wrzesinski, J.; Pawlat, T. [and others

    1996-12-31

    The two most prominent examples of the heavy doubly closed shell (DCS) nuclei, {sup 208}Pb and {sup 132}Sn, are not accessible by conventional heavy-ion fusion processes populating high-spin states. This experimental difficulty obscured for a long time the investigation of yrast high-spin states in both DCS and neighboring nuclei and consequently restricted the study of the shell model in its most attractive regions. Recent technical development of multidetector gamma arrays opened new ways to exploit more complex nuclear processes which populate the nuclei of interest with suitable yields for gamma spectroscopy and involve population of moderately high spin states. This new possibility extended the range of accessible spin values and is a promising way to reach new yrast states. Some of these states are expected to be of high configurational purity and can be a source of important shell model parameters which possibly can be used later to check the validity of the spherical shell model description at yet higher spin and higher excitation energy. The nuclei in the closest vicinity of {sup 132}Sn are produced in spontaneous fission and states with spin values up to I=14 can be reached in fission gamma spectroscopy studies with the presently achieved sensitivity of gamma arrays. New results on yrast states in the {sup 134}Te and {sup 135}I nuclei populated in fission of the {sup 248}Cm presented at this conference illustrate such application of the resolving power offered by modern gamma techniques.

  11. Electric dipole excitation of {sup 208}Pb by polarized electron impact

    Energy Technology Data Exchange (ETDEWEB)

    Jakubassa-Amundsen, D.H. [University of Munich, Mathematics Institute, Munich (Germany); Ponomarev, V.Yu. [Technische Universitaet Darmstadt, Institut fuer Kernphysik, Darmstadt (Germany)

    2016-03-15

    The cross sections and spin asymmetries for the excitation of 1{sup -} states in {sup 208}Pb by transversely polarized electrons with collision energy of 30-180MeV have been examined within the DWBA scattering formalism. As examples, we have considered a low-lying 1{sup -} state and also states belonging to the pygmy dipole and giant dipole resonances. The structure of these states and their corresponding transition charge and current densities have been taken from an RPA calculation within the quasiparticle phonon model. The complex-plane rotation method has been applied to achieve the convergence of the radial DWBA integrals for backward scattering. We have studied the behaviour of the cross sections and spin asymmetries as a function of electron energy and scattering angle. The role of the longitudinal and transversal contributions to the excitation has been thoroughly studied. We conclude that the spin asymmetry S, related to unpolarized outgoing electrons, is mostly well below 1% even at the backward scattering angles and its measurement provides a challenge for future experiments with polarized electrons. (orig.)

  12. Dipole response in 208Pb within a self-consistent multiphonon approach

    CERN Document Server

    Knapp, F; Vesely, P; Andreozzi, F; De Gregorio, G; Porrino, A

    2015-01-01

    Background: The electric dipole strength detected around the particle threshold and commonly associated to the pygmy dipole resonance offers a unique information on neutron skin and symmetry energy, and is of astrophysical interest. The nature of such a resonance is still under debate. Purpose: We intend to describe the giant and pygmy resonances in 208 Pb by enhancing their fragmentation with respect to the random-phase approximation. Method: We adopt the equation of motion phonon method to perform a fully self-consistent calculation in a space spanned by one-phonon and two-phonon basis states using an optimized chiral two-body potential. A phenomenological density dependent term, derived from a contact three-body force, is added in order to get single-particle spectra more realistic than the ones obtained by using the chiral potential only. The calculation takes into full account the Pauli principle and is free of spurious center of mass admixtures. Results: We obtain a fair description of the giant resonan...

  13. Elastic Neutron Scattering at 96 MeV from {sup 12}C and {sup 208}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Klug, J.; Blomgren, J.; Atac, A. [and others

    2003-04-01

    A facility for detection of scattered neutrons in the energy interval 50-130 MeV, SCANDAL (SCAttered Nucleon Detection AssembLy), has recently been installed at the 20-180 MeV neutron beam line of the The Svedberg Laboratory, Uppsala. Elastic neutron scattering from {sup 12}C and {sup 208}Pb has been studied at 96 MeV in the 10-70 deg interval. The achieved energy resolution, 3.7 MeV, is about an order of magnitude better than for any previous experiment above 65 MeV incident energy. The present experiment represents the highest neutron energy where the ground state has been resolved from the first excited state in neutron scattering. A novel method for normalization of the absolute scale of the cross section has been used. The estimated uncertainty, 3 %, is unprecedented for a neutron-induced differential cross section measurement on a nuclear target. The results are compared with modern optical model predictions, based on phenomenology or microscopic nuclear theory.

  14. Long Acting Single Injection Caudal Anesthesia—1,208 Obstetrical Deliveries with Mepivacaine

    Science.gov (United States)

    Gunther, Ronald E.; Harer, W. Benson

    1966-01-01

    Long acting, single injection caudal anesthesia with mepivacaine was studied in 1,208 obstetrical cases. A 1 per cent solution was used in 671 patients and compared with a 1.5 per cent concentration in 537. No remarkable differences were found between the two groups. The 1 per cent solution provided relief of labor discomfort for from 60 to 180 minutes with an average of 110 minutes. In contrast, the 1.5 per cent solution provided an average of 115 minutes with a range of 80 to 210 minutes. A total volume of 30 ml of anesthetic agent yielded anesthesia to a level of the tenth thoracic vertebra or higher in 91 per cent of patients. Significant alterations in blood pressure were uncommon. About 1 per cent of patients required a vasopressor because of a drop in systolic blood pressure below 80 mm of mercury. Another 8 per cent had a drop of over 20 points in systolic pressure but from high enough levels that they did not require a vasopressor. Toxic effects similar to those of lidocaine were found in slightly more than 1 per cent of cases. This anesthesia requires a higher incidence of operative intervention for delivery. PMID:5980717

  15. 208国道司庄二号大桥病害分析及加固措施%Diseases analysis and reinforcement measures Sizhuang No. 2 big bridge of 208 national highway

    Institute of Scientific and Technical Information of China (English)

    胡芳

    2012-01-01

    在分析208国道司庄二号大桥病害情况的基础上,列举了病害产生原因,通过验算分析提出了桥梁维修加固措施,并根据加固设计进行了加固效果验算,结果表明:加固后提高了新增两铰拱的抗弯承载能力,满足了规范要求。%On the basis of analysing on diseases situations of Sizhuang No. 2 big bridge of 208 national highway, this paper listed the diseases causes, through the checking analysis proposed bridge repair and reinforcement measures, and according to the reinforcement design made rein-forcement checking calculation, the results showed that after reinforcement increased the bending bearing capacity of additional two hinged arch, met the requirements of specification.

  16. Study of the {sup 40}Ar + {sup 208}Pb reaction using the {sup 40}Ar Piave-ALPI test beam and the Prisma-Clara set-up

    Energy Technology Data Exchange (ETDEWEB)

    Stefanini, A.M.; Marginean, N.; Corradi, L. [INFN, Laboratori Nazionali di Legnaro Padova (Italy)] (and others)

    2005-07-01

    The study of few- and multi-nucleon transfer reactions in the system {sup 40}Ar + {sup 208}Pb may offer interesting results, also in the comparison with what we obtained in the recent study of {sup 40}Ca + {sup 208}Pb where clear evidences of simultaneous nucleon pair transfer have been found. Moreover, the case of {sup 40}Ar + {sup 208}Pb is attractive from the point of view of the possibility of populating neutron-rich nuclei in the sulphur-silicon region with non-negligible cross sections, for nuclear structure studies.

  17. Residue excitation functions from complete fusion of [sup 16]O with [sup 197]Au and [sup 208]Pb

    Energy Technology Data Exchange (ETDEWEB)

    Brinkmann, K.; Caraley, A.L.; Fineman, B.J.; Gan, N.; Velkovska, J.; McGrath, R.L. (Physics Department, State University of New York at Stony Brook, Stony Brook, New York 11794 (United States))

    1994-07-01

    Evaporation residue excitation functions and [alpha]-multiplicities from complete fusion of [sup 16]O with [sup 197]Au and [sup 208]Pb have been measured from the fusion threshold up to 140 MeV incident energy. The data allow the conclusion that strongly overdamped motion cannot be dominant at energies in the vicinity of the fusion barrier below [ital E][sup *][approx]50 MeV. At excitation energies above 50 MeV the residue cross section for [sup 16]O+[sup 208]Pb is much greater than predicted from the statistical model with conventional parametrizations. The enhancement is not explained by incorporating dynamical effects into the analysis. An alternative suggestion based on deexcitation-chain dependent fission barriers is discussed.

  18. Microstructure and microhardness of CLAM steel irradiated up to 20.8 dpa in STIP-V

    Science.gov (United States)

    Peng, Lei; Ge, Hongen; Dai, Yong; Huang, Qunying; Ye, Minyou

    2016-01-01

    Specimens of China low activation martensitic (CLAM) steel were irradiated in the fifth experiment of SINQ target irradiation program (STIP-V) up to 20.8 dpa/1564 appm He. Microhardness measurements and transmission electron microscope (TEM) observations have been performed to investigate irradiation induced hardening effects. The results of CLAM steel specimens show similar trend in microhardness and microstructure changes with irradiation dose, compared to F82H/Optimax-A steels irradiated in STIP-I/II. Defects and helium bubbles were observed in all specimens, even at a very low dose of 5.4 dpa. For defects and bubbles, the mean size and number density increased with increasing irradiation dose to 13 dpa, and then the mean size increased and number density decreased with the increasing irradiation dose to 20.8 dpa.

  19. Theoretical study of the similarity between nuclei with four valence nucleons in A = 208, 132 and 68 regions

    Energy Technology Data Exchange (ETDEWEB)

    Benmicia, N.; Benrachi, F. [Laboratoire de Physique Mathematique et Subatomique, Majister, Mentouri University, Constantine (Algeria)

    2012-06-27

    One of the most interesting topics in nuclear structure is the study of nuclei near the limits of particle stability. Much attention is currently being focused on nuclei with few valence nucleons around Z= 28, 50 and 82, in particular the 68Ni, 132Sn and 208Pb neighbors. We are interested of the even-even isobars 72Ni, 72Ge and 72Zn in 68Ni region, 136Sn, 136Xe and 136Te in 132Sn region, 212Pb, 212Rn and 212Po in 208Pb region. The calculation of energies spectra using the effective interactions JUN45M, CW{Delta}5082 and KHP shows a good agreement with the available experimental data for the energie levels and their sequences. We have extended the existed similarity between lead and tin regions to the Nickel region.

  20. Isospin Character of Low-Lying Pygmy Dipole States in Pb208 via Inelastic Scattering of O17 Ions

    Science.gov (United States)

    Crespi, F. C. L.; Bracco, A.; Nicolini, R.; Mengoni, D.; Pellegri, L.; Lanza, E. G.; Leoni, S.; Maj, A.; Kmiecik, M.; Avigo, R.; Benzoni, G.; Blasi, N.; Boiano, C.; Bottoni, S.; Brambilla, S.; Camera, F.; Ceruti, S.; Giaz, A.; Million, B.; Morales, A. I.; Vandone, V.; Wieland, O.; Bednarczyk, P.; Ciemała, M.; Grebosz, J.; Krzysiek, M.; Mazurek, K.; Zieblinski, M.; Bazzacco, D.; Bellato, M.; Birkenbach, B.; Bortolato, D.; Calore, E.; Cederwall, B.; Charles, L.; de Angelis, G.; Désesquelles, P.; Eberth, J.; Farnea, E.; Gadea, A.; Görgen, A.; Gottardo, A.; Isocrate, R.; Jolie, J.; Jungclaus, A.; Karkour, N.; Korten, W.; Menegazzo, R.; Michelagnoli, C.; Molini, P.; Napoli, D. R.; Pullia, A.; Recchia, F.; Reiter, P.; Rosso, D.; Sahin, E.; Salsac, M. D.; Siebeck, B.; Siem, S.; Simpson, J.; Söderström, P.-A.; Stezowski, O.; Theisen, Ch.; Ur, C.; Valiente-Dobón, J. J.

    2014-07-01

    The properties of pygmy dipole states in Pb208 were investigated using the Pb208(O17, O17'γ) reaction at 340 MeV and measuring the γ decay with high resolution with the AGATA demonstrator array. Cross sections and angular distributions of the emitted γ rays and of the scattered particles were measured. The results are compared with (γ, γ') and (p, p') data. The data analysis with the distorted wave Born approximation approach gives a good description of the elastic scattering and of the inelastic excitation of the 2+ and 3- states. For the dipole transitions a form factor obtained by folding a microscopically calculated transition density was used for the first time. This has allowed us to extract the isoscalar component of the 1- excited states from 4 to 8 MeV.

  1. Isospin character of low-lying pygmy dipole states in 208Pb via inelastic scattering of 17O ions.

    Science.gov (United States)

    Crespi, F C L; Bracco, A; Nicolini, R; Mengoni, D; Pellegri, L; Lanza, E G; Leoni, S; Maj, A; Kmiecik, M; Avigo, R; Benzoni, G; Blasi, N; Boiano, C; Bottoni, S; Brambilla, S; Camera, F; Ceruti, S; Giaz, A; Million, B; Morales, A I; Vandone, V; Wieland, O; Bednarczyk, P; Ciemała, M; Grebosz, J; Krzysiek, M; Mazurek, K; Zieblinski, M; Bazzacco, D; Bellato, M; Birkenbach, B; Bortolato, D; Calore, E; Cederwall, B; Charles, L; de Angelis, G; Désesquelles, P; Eberth, J; Farnea, E; Gadea, A; Görgen, A; Gottardo, A; Isocrate, R; Jolie, J; Jungclaus, A; Karkour, N; Korten, W; Menegazzo, R; Michelagnoli, C; Molini, P; Napoli, D R; Pullia, A; Recchia, F; Reiter, P; Rosso, D; Sahin, E; Salsac, M D; Siebeck, B; Siem, S; Simpson, J; Söderström, P-A; Stezowski, O; Theisen, Ch; Ur, C; Valiente-Dobón, J J

    2014-07-04

    The properties of pygmy dipole states in 208Pb were investigated using the 208Pb(17O, 17O'γ) reaction at 340 MeV and measuring the γ decay with high resolution with the AGATA demonstrator array. Cross sections and angular distributions of the emitted γ rays and of the scattered particles were measured. The results are compared with (γ, γ') and (p, p') data. The data analysis with the distorted wave Born approximation approach gives a good description of the elastic scattering and of the inelastic excitation of the 2+ and 3- states. For the dipole transitions a form factor obtained by folding a microscopically calculated transition density was used for the first time. This has allowed us to extract the isoscalar component of the 1- excited states from 4 to 8 MeV.

  2. Total fission cross section of {sup 181}Ta and {sup 208}Pb induced by protons at relativistic energies

    Energy Technology Data Exchange (ETDEWEB)

    Ayyad, Y.; Benlliure, J.; Casarejos, E. [Group GENP, Dpto. Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Schmidt, K. H. [GSI, Planckstrasse 1, 64941, Darmstadt (Germany); Jurado, B. [Universite Bordeaux I, CNRS/IN2 P3, CENBG, BP 120, F-33175 Gradignan (France); Kelic-Heil, A. [GSI, Planckstrasse 1, 64941, Darmstadt (Germany); Pol, H. A. [Group GENP, Dpto. Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Ricciardi, M. V.; Pleskac, R. [GSI, Planckstrasse 1, 64941, Darmstadt (Germany); Enqvist, T. [CUPP Project, P.O. Box 22, FI-86801, Pyhsalmi (Finland); Rejmund, F. [Grand Accelerateur National D Ions Lourds, BP 55027, F-14076 Caen Cedex 05 (France); Giot, L. [Subatech - Ecole des Mines de Nantes (France); Henzl, V. [Massachusetts Inst. of Technology, 77, Massachusetts Ave, Cambridge, MA 02139 (United States); Lukic, S. [Karlsruhe Inst. of Technology, D-76021 Karlsruhe (Germany); Ngoc, S. N. [Dept. of Nuclear Physics, Inst. of Physics, National Centre for Natural Science and Technology, NgiaDo-TuLiem, Hanoi (Viet Nam); Boudard, A. [DSM/IRFU/CEA, 91191 Gif-sur-Ivette (France); Universite Louis Pasteur, Strasbourg (France); Leray, S. [DSM/IRFU/CEA, 91191 Gif-sur-Ivette (France); Fernandez, M. [Entro de Investigaciones Energticas Medioambientales Y Tecnolgicas, Madrid (Spain); Kurtukian, T. [Universite Bordeaux I, CNRS/IN2 P3, CENBG, BP 120, F-33175 Gradignan (France); Nadtochy, P. [Omsk State Univ., Dept. of Theoretical Physics, RU-644077 Omsk (Russian Federation); Schmitt, C. [Grand Accelerateur National D' Ions Lourds, BP 55027, F-14076 Caen Cedex 05 (France); Henzlova, D. [Los Alamos National Laboratory, Safeguards Science and Technology Group N-1, Los Alamos, NM 87545 (United States); Paradela, C. [Group GENP, Dpto. Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Bacquias, A. [DSM/IRFU/CEA, 91191 Gif-sur-Ivette (France); Universite Louis Pasteur, Strasbourg (France); Loureiro, D. P. [Group GENP, Dpto. Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Foehr, V. [GSI, Planckstrasse 1, 64941, Darmstadt (Germany); Tarrio, D. [Group GENP, Dpto. Fisica de Particulas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela (Spain); Kezzar, K. [DSM/IRFU/CEA, 91191 Gif-sur-Ivette (France)

    2011-07-01

    Total fission cross section induced by protons in {sup 181}Ta and {sup 208}Pb at energies in the range of 300 to 1000 A MeV have been measured at GSI (Germany) using the inverse kinematics technique. A dedicated setup with high efficiency made it possible to determine these cross sections with high accuracy. The new data seed light in the controversial results obtained so far and contribute to the understanding of the fission process at high excitation energies. (authors)

  3. Probing Shell Correction at High Spin by Neutron Emission of Doubly Magic Nuclei 208pb and 132Sn

    Institute of Scientific and Technical Information of China (English)

    YEWei

    2005-01-01

    Shell effects in particle emission for two doubly magic nuclei 132Sn and 208pb were studied in the framework of Smoluchowski equation taking into account temperature and spin-dependent shell correction. It is shown that the shelle ffects in the emission of pre-scission neutrons are sensitive to the spin dependence of the shell correction at a moderate excitation energy. Therefore, we propose to use neutron multiplicity as an observable to probe the shell correction at high spins.

  4. Probing Shell Correction at High Spin by Neutron Emission of Doubly Magic Nuclei 208pb and 132Sn

    Institute of Scientific and Technical Information of China (English)

    YE Wei

    2005-01-01

    Shell effects in particle emission for two doubly magic nuclei 132 Sn and 208 Pb were studied in the framework of Smoluchowski equation taking into account temperature and spin-dependent shell correction. It is shown that the shell effects in the enission of pre-scission neutrons are sensitive to the spin dependence of the shell correction at a moderate excitation energy. Therefore, we propose to use neutron multiplicity as an observable to probe the shell correction at high spins.

  5. α particle particle production in the scattering of He-6 by Pb-208 at energies around the Coulomb barrier

    OpenAIRE

    Escrig, Diego; Sánchez Benítez, Ángel Miguel; Moro, A. M.; González Álvarez, Marcos A.; Andrés, M. V.; Angulo, C.; García Borge, María José; Cabrera Caño, Jesús; Cherubini, S.; Damaret, P.; Espino, José Manuel; Figuera, P.; Freer, M.; García Ramos, José Enrique; Gómez Camacho, Joaquín

    2007-01-01

    New experimental data from the scattering of 6He + 208Pb at energies around and below the Coulomb barrier are presented. The yield of breakup products coming from projectile fragmentation is dominated by a strong group of α particles. The energy and angular distribution of this group have been analyzed and compared with theoretical calculations. This analysis indicates that the α particles emitted at backward angles in this reaction are mainly due to two-neutron transfer to weakly bound state...

  6. Transverse energy production in {sup 208}Pb+Pb collisions at 158 GeV per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Alber, T.; Appelshaeuser, H.; Baechler, J.; Bartke, J.; Bialkowska, H.; Bieser, F.; Bloomer, M.A.; Blyth, C.O.; Bock, R.; Bormann, C.; Brady, F.P.; Brockmann, R.; Buncic, P.; Caines, H.L.; Cebra, D.; Chan, P.; Cooper, G.E.; Cramer, J.G.; Cramer, P.B.; Csato, P.; Derado, I.; Dunn, J.; Eckardt, V.; Eckhardt, F.; Euler, S.; Ferguson, M.I.; Fischer, H.G.; Fodor, Z.; Foka, P.; Freund, P.; Fuchs, M.; Gal, J.; Gazdzicki, M.; Gladysz, E.; Grebieszkow, J.; Guenther, J.; Harris, J.W.; Heck, W.; Hegyi, S.; Hill, L.A.; Huang, I.; Howe, M.A.; Igo, G.; Irmscher, D.; Jacobs, P.; Jones, P.G.; Kadija, K.; Kecskemeti, J.; Kowalski, M.; Kuehmichel, A.; Lasiuk, B.; Margetis, S.; Mitchell, J.W.; Mock, A.; Nelson, J.M.; Odyniec, G.; Palinkas, J.; Palla, G.; Panagiotou, A.D.; Petridis, A.; Piper, A.; Poskanzer, A.M.; Prindle, D.J.; Puehlhofer, F.; Rauch, W.; Renfordt, R.; Retyk, W.; Ritter, H.G.; Roehrich, D.; Rudolph, H.; Runge, K.; Sandoval, A.; Sann, H.; Schaefer, E.; Schmitz, N.; Schoenfelder, S.; Seyboth, P.; Seyerlein, J.; Sikler, F.; Skrzypczak, E.; Stock, R.; Stroebele, H.; Szentpetery, I.; Sziklai, J.; Toy, M.; Trainor, T.A.; Trentalange, S.; Vassiliou, M.; Vesztergombi, G.; Vranic, D.; Wenig, S.; Whitten, C.; Wienold, T.; Wood, L.; Zimanyi, J.; Zhu, X.; Zybert, R. [Department of Physics, University of Athens, Athens (Greece)]|[Lawrence Berkeley Laboratory, University of California, Berkeley California (United States)]|[Birmingham University, Birmingham (United Kingdom)]|[Institute of Physics, Budapest (Hungary)]|[CERN, Geneva (Switzerland)]|[Institute of Nuclear Physics, Cracow (Poland)]|[Gesellschaft fuer Schwerionenforschung (GSI), Darmstadt (Germany)]|[University of California at Davis, Davis California (United States)]|[Fachbereich Physik der Universitaet, Frankfurt (Germany)]|[Fachbereich Physik der Universitaet, Freiburg (Germany)]|[University of California at Los Angeles, Los Angeles California (United States)

    1995-11-20

    Measurements of the forward and the transverse energy in 158 GeV per nucleon {sup 208}Pb+Pb collisions are presented. A total transverse energy of about 1 TeV is created in central collisions. An energy density of about 3GeV/fm{sup 3} is estimated for near head-on collisions. Only statistical fluctuations are seen in the ratio of electromagnetic to hadronic transverse energy. {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.

  7. Search for single top production via FCNC at LEP at $\\sqrt{s}$ = 189-208 GeV

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alderweireld, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Berntzon, L; Bertrand, D; Besançon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Brückman, P; Brunet, J M; Bugge, L; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F R; Chapkin, M M; Charpentier, P; Checchia, P; Chierici, R; Shlyapnikov, P; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M J; Crawley, B; Crennell, D J; Cuevas-Maestro, J; D'Hondt, J; Dalmau, J; Da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L S; Di Ciaccio, Lucia; Di Simone, A; Doroba, K; Drees, J; Dris, M; Eigen, G; Ekelöf, T J C; Ellert, M; Elsing, M; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Feindt, M; Fernández, J; Ferrer, A; Ferro, F; Flagmeyer, U; Föth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J A; Gandelman, M; García, C; Gavillet, P; Gazis, E N; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Herr, H; Hoffman, J; Holmgren, S O; Holt, P J; Houlden, M A; Hultqvist, K; Jackson, J N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E K; Johansson, P D; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E C; Kernel, G; Kersevan, Borut P; Kerzel, U; Kiiskinen, A P; King, B T; Kjaer, N J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kuznetsov, O; Krumshtein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; López, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Meyer, W T; Migliore, E; Mitaroff, W A; Mjörnmark, U; Moa, T; Moch, M; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Müller, U; Münich, K; Mulders, M; Mundim, L M; Murray, W; Muryn, B; Myatt, G; Myklebust, T; Nassiakou, M; Navarria, Francesco Luigi; Nawrocki, K; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, R; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V F; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Pozdnyakov, V; Pukhaeva, N; Pullia, Antonio; Rames, J; Ramler, L; Read, A; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P B; Richard, F; Rídky, J; Rivero, M; Rodríguez, D; Romero, A; Ronchese, P; Rosenberg, E I; Roudeau, Patrick; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovskii, A; Salmi, L; Salt, J; Savoy-Navarro, A; Schwickerath, U; Segar, A; Sekulin, R L; Siebel, M; Sissakian, A N; Smadja, G; Smirnova, O G; Sokolov, A; Sopczak, A; Sosnowski, R; Spassoff, Tz; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Timmermans, J; Tkatchev, L G; Tobin, M; Todorovova, S; Tomé, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M L; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; van Dam, P; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I B; Vegni, G; Veloso, F; Venus, W A; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O P; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zhuravlov, V; Zimin, N I; Zinchenko, A I; Zupan, M

    2004-01-01

    A search for single top production (e+e- -> t cbar) via Flavour Changing Neutral Currents (FCNC) was performed using the data taken by the DELPHI detector at LEP2. The data analysed have been accumulated at centre-of-mass energies ranging from 189 to 208 GeV. Limits at 95% confidence level were obtained on the anomalous coupling parameters kappa_gamma and kappa_Z.

  8. Study of the elastic scattering of 6He on 208Pb at energies around the Coulomb barrier

    OpenAIRE

    Sanchez-Benitez, A M; Escrig, D.; Alvarez, M. A.; Andres, M. V.; Angulo, Carmen; Borge, M. J. G.; J. Cabrera; Cherubini, F.; Demaret, P; Espino, J. M.; Figuera, P.; Freer, Martin; Garcia-Ramos, J. E.; Gomez-Camacho, J.; Gulino, M.

    2008-01-01

    The elastic scattering of 6He on 208Pb has been measured at laboratory energies of 14, 16, 18 and 22 MeV. These data were analyzed using phenomenological Woods- Saxon form factors and optical model calculations. A semiclassical polarization po- tential was used to study the e ect of the Coulomb dipole polarizability. Evidence for long range absorption, partially arising from Coulomb dipole polarizability, is reported. The energy variation of the optical potential was found to b...

  9. alpha-particle production in the scattering of 6He by 208Pb at energies around the Coulomb barrier

    OpenAIRE

    Escrig, D.; Sanchez-Benitez, A M; Moro, A. M.; Alvarez, M. A. G.; Andres, M. V.; Angulo, C.; Borge, M. J. G.; J. Cabrera; Cherubini, S.; Demaret, P; Espino, J. M.; Figuera, P.; Freer, M.; Garcia-Ramos, J. E.; Gomez-Camacho, J.

    2007-01-01

    New experimental data from the scattering of 6He+208Pb at energies around and below the Coulomb barrier are presented. The yield of breakup products coming from projectile fragmentation is dominated by a strong group of $\\alpha$ particles. The energy and angular distributions of this group have been analyzed and compared with theoretical calculations. This analysis indicates that the $\\alpha$ particles emitted at backward angles in this reaction are mainly due to two-neutron transfer to weakl...

  10. Elastic scattering of the halo nucleus {sup 6}He from {sup 208}Pb above the Coulomb barrier

    Energy Technology Data Exchange (ETDEWEB)

    Kakuee, O.R.; Rahighi, J.; Sanchez-Benitez, A.M.; Andres, M.V.; Cherubini, S.; Davinson, T.; Galster, W.; Gomez-Camacho, J. E-mail: gomez@nucle.us.es; Laird, A.M.; Lamehi-Rachti, M.; Martel, I.; Shotter, A.C.; Smith, W.B.; Vervier, J.; Woods, P.J

    2003-12-15

    Elastic scattering of {sup 6}He at E{sub lab}=27 MeV with {sup 208}Pb has been measured in the angular range of 6 deg.-72 deg.in the laboratory system employing LEDA and LAMP detection systems. Optical Model calculations have been performed using dynamic polarisation potential. The role of Coulomb dipole polarizability has been investigated. Large values of the imaginary diffuseness parameter are required in order to fit the data.

  11. cDNA microarray detection of 208 lung cancer-related genes in seven samples of lung squamous cell carcinoma%肺鳞癌组织中208个肺癌相关基因的表达

    Institute of Scientific and Technical Information of China (English)

    范保星; 孙敬芬; 解立新; 陈良安; 刘又宁; 王升启; 吴德昌

    2003-01-01

    AIM:To investigate the differences in the expressions of lung cancer- related genes in seven tissue specimens of lung squamous cell carcinoma by means of cDNA microarray technique,so as to provide molecular information for the treatment and prognostic assessment of the patients. METHODS:The total RNA of 7 lung squamous cell carcinomas tissues samples was extracted, reverse transcripted and fluorescent- labeled to be used as probes through LD- PCR.Hybridization of the probes with the cDNA chip that contained 208 lung cancer- related genes was performed,the results analyzed using imagene software. RESULTS: The 7 samples share a similarity ranging from 60.65% to 82.69% in the expressions of 208 lung cancer- related genes. CONCLUSION:It is identified for the first time that the gene expression profiles might differ in certain aspect among different lung squamous cell carcinomas,a fact that justifies more individualized diagnosis and treatment of the cancer patients.%目的 :病理学上诊断同样为肺鳞癌的患者,其治疗疗效和愈后往往存在一定差异,本研究利用本实验室制作的 208个肺癌相关基因芯片,探讨了 7例肺鳞癌组织中基因表达的异质性,试图为患者的治疗和预后提供分子依据. 方法 :提取 7例男性肺鳞癌患者(年龄在 55~ 65岁之间)癌组织的总 RNA并用 LD- PCR标记成探针,然后与含有 208个肺癌相关基因的 cDNA Microarray杂交,芯片用 ImaGene软件分析和处理数据. 结果 :7例肺鳞癌组织之间 208个肺癌相关基因表达的相似性在 60.65% ~ 82.69%之间. 结论 :本研究首次对肺鳞癌患者不同个体之间基因的表达进行研究并发现存在一定的差异,提示应注意癌症患者的个体化诊断和治疗.

  12. Gamma strength function and level densities of $^{208}$Pb from forward-angle proton scattering at 295 MeV

    CERN Document Server

    Bassauer, S; Tamii, A

    2016-01-01

    Gamma strength functions (GSFs) and level densities (LDs) are essential ingredients of statistical nuclear reaction theory with many applications in astrophysics, reactor design, and waste transmutation. The aim of the present work is a test of systematic parametrizations of the GSF recommended by the RIPL-3 data base for the case of $^{208}$Pb. The upward GSF and LDs in $^{208}$Pb are compared to gamma decay data from an Oslo-type experiment to examine the validity of the Brink-Axel (BA) hypothesis. The E1 and M1 parts of the total GSF are determined from high-resolution forward angle inelastic proton scattering data taken at 295 MeV at RCNP, Osaka, Japan. Total LDs in $^{208}$Pb are derived from $1^-$ LDs extracted with a fluctuation analysis in the energy region of the isovector giant dipole resonance. The E1 GSF is compared to parametrizations recommended by the RIPL-3 data base showing systematic deficiencies of all models in the energy region around neutron threshold. The new data for the poorly known s...

  13. Study of shell evolution around the doubly magic $^{208}$Pb via a multinucleon transfer reaction with an unstable beam

    CERN Multimedia

    This proposal aims at the study of the neutron-rich region around the doubly-magic nucleus $^{208}$Pb populated via a multinucleon transfer reaction. An unstable $^{94}$Rb beam will be delivered by HIE-ISOLDE at 5.5 MeV$\\cdot$u onto a $^{208}$Pb 13.0 mg/cm$^{2}$ target. The $\\gamma$- rays will be recorded by the MINIBALL $\\gamma$-ray spectrometer. The aim of the experiment is twofold: \\\\ \\\\ i) firstly it will represent the proof of principle that multinucleon transfer reactions with neutron-rich unstable beams is efficient to populate neutron-rich heavy binary partners and represents a competitive method to cold fragmentation \\\\ ii) secondly we aim at populating medium- to high-spin states in $^{212;214}$Pb and $^{208;210}$Hg to elucidate the existence of the 16$^{+}$ isomer in the lead isotopes and at the same time to disentangle the puzzling case of a very low energy 3$^{-}$ state in $^{210}$Hg not described by any nuclear model. \\\\ \\\\ The experimental results will be compared with large-scale shell-model ...

  14. ATRAGEREA MINORILOR LA ACTIVITATE CRIMINALĂ: MODALITATE NORMATIVĂ DE EXPRIMARE A FAPTEI PREJUDICIABILE CONSEMNATE LA ART.208 CP RM

    Directory of Open Access Journals (Sweden)

    Stanislav COPEŢCHI

    2015-11-01

    Full Text Available În cadrul studiului întreprins este supusă investigaţiei atragerea minorilor la activitate criminală, în calitate de faptă prejudiciabilă alternativă prevăzută la art.208 CP RM. Se argumentează că atragerea minorilor la activitate criminală trebuie delimitată de instigarea minorilor la săvârşirea infracţiunilor, ceea ce nu de fiecare dată are loc în practica judiciară. Sunt elucidate modalităţile faptice de exprimare a faptei de atragere a minorilor la activitate criminală.ATRACT MINORS IN CRIMINAL ACTIVITY: NORMATIVE WAY OF EXPRESSION PREJUDICIAL ACT STIPULATED IN ART.208 PC RM Within the undertaken study is being investigated act of attracting minors in criminal activity, as an alternative prejudicial act provided for in art.208 PC RM. It is argued that attract minors in criminal activity must be delimited by instigation of minors to commit crimes, which does not always take place in the judicial practice.

  15. Evaluation of antitumor activity of a TGF-beta receptor I inhibitor (SD-208) on human colon adenocarcinoma.

    Science.gov (United States)

    Akbari, Abolfazl; Amanpour, Saeid; Muhammadnejad, Samad; Ghahremani, Mohammad Hossein; Ghaffari, Seyed Hamidollah; Dehpour, Ahmad Reza; Mobini, Gholam Reza; Shidfar, Fatemeh; Abastabar, Mahdi; Khoshzaban, Ahad; Faghihloo, Ebrahim; Karimi, Abbas; Heidari, Mansour

    2014-06-05

    Transforming growth factor-β (TGF-β) pathway is involved in primary tumor progression and in promoting metastasis in a considerable proportion of human cancers such as colorectal cancer (CRC). Therefore, blockage of TGF-β pathway signaling via an inhibitor could be a valuable tool in CRC treatment. To evaluate the efficacy of systemic targeting of the TGF-β pathway for therapeutic effects on CRC, we investigated the effects of a TGβRI (TGF-β receptor 1) or TβRI kinase inhibitor, SD-208, on SW-48, colon adenocarcinoma cells. In this work, in vitro cell proliferation was studied by methyl thiazolyl tetrazolium (MTT) and bromo-2'-deoxyuridine (BrdU) assays. Also, the histopathological and immunohistochemical evaluations were conducted by hematoxylin and eosin, and Ki-67 and CD34 markers were stained, respectively. Our results showed no significant reduction in cell proliferation and vessel formation (170 ± 70 and 165 ± 70, P > 0.05) in treated SW-48 cells with SD-208 compared to controls. Our data suggested that SD-208 could not significantly reduce tumor growth and angiogenesis in human colorectal cancer model at least using SW-48 cells.

  16. Radiogenic Lead with Dominant Content of 208Pb: New Coolant and Neutron Moderator for Innovative Nuclear Facilities

    Directory of Open Access Journals (Sweden)

    A. N. Shmelev

    2011-01-01

    Full Text Available As a rule materials of small atomic weight (light and heavy water, graphite, and so on are used as neutron moderators and reflectors. A new very heavy atomic weight moderator is proposed—radiogenic lead consisting mainly of isotope 208Pb. It is characterized by extremely low neutron radiative capture cross-section (0.23 mbarn for thermal neutrons, i.e., less than that for graphite and deuterium and highest albedo of thermal neutrons. It is evaluated that the use of radiogenic lead makes it possible to slow down the chain fission reaction on prompt neutrons in a fast reactor. This can increase safety of the fast reactors and reduce as well requirements pertaining to the fuel fabrication technology. Radiogenic lead with high 208Pb content as a liquid-metal coolant of fast reactors helps to achieve a favorable (negative reactivity coefficient on coolant temperature. It is noteworthy that radiogenic lead with high 208Pb content may be extracted from thorium (as well as thorium-uranium ores without isotope separation. This has been confirmed experimentally by the investigations performed at San Paulo University, Brazil.

  17. Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients.

    Science.gov (United States)

    Rostomyan, Liliya; Daly, Adrian F; Petrossians, Patrick; Nachev, Emil; Lila, Anurag R; Lecoq, Anne-Lise; Lecumberri, Beatriz; Trivellin, Giampaolo; Salvatori, Roberto; Moraitis, Andreas G; Holdaway, Ian; Kranenburg-van Klaveren, Dianne J; Chiara Zatelli, Maria; Palacios, Nuria; Nozieres, Cecile; Zacharin, Margaret; Ebeling, Tapani; Ojaniemi, Marja; Rozhinskaya, Liudmila; Verrua, Elisa; Jaffrain-Rea, Marie-Lise; Filipponi, Silvia; Gusakova, Daria; Pronin, Vyacheslav; Bertherat, Jerome; Belaya, Zhanna; Ilovayskaya, Irena; Sahnoun-Fathallah, Mona; Sievers, Caroline; Stalla, Gunter K; Castermans, Emilie; Caberg, Jean-Hubert; Sorkina, Ekaterina; Auriemma, Renata Simona; Mittal, Sachin; Kareva, Maria; Lysy, Philippe A; Emy, Philippe; De Menis, Ernesto; Choong, Catherine S; Mantovani, Giovanna; Bours, Vincent; De Herder, Wouter; Brue, Thierry; Barlier, Anne; Neggers, Sebastian J C M M; Zacharieva, Sabina; Chanson, Philippe; Shah, Nalini Samir; Stratakis, Constantine A; Naves, Luciana A; Beckers, Albert

    2015-10-01

    Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients. We included 208 patients (163 males; 78.4%) with growth hormone excess and a current/previous abnormal growth velocity for age or final height >2 s.d. above country normal means. The median onset of rapid growth was 13 years and occurred significantly earlier in females than in males; pituitary adenomas were diagnosed earlier in females than males (15.8 vs 21.5 years respectively). Adenomas were ≥10 mm (i.e., macroadenomas) in 84%, of which extrasellar extension occurred in 77% and invasion in 54%. GH/IGF1 control was achieved in 39% during long-term follow-up. Final height was greater in younger onset patients, with larger tumors and higher GH levels. Later disease control was associated with a greater difference from mid-parental height (r=0.23, P=0.02). AIP mutations occurred in 29%; microduplication at Xq26.3 - X-linked acrogigantism (X-LAG) - occurred in two familial isolated pituitary adenoma kindreds and in ten sporadic patients. Tumor size was not different in X-LAG, AIP mutated and genetically negative patient groups. AIP-mutated and X-LAG patients were significantly younger at onset and diagnosis, but disease control was worse in genetically negative cases. Pituitary gigantism patients are characterized by male predominance and large tumors that are difficult to control. Treatment delay increases final height and symptom burden. AIP mutations and X-LAG explain many cases, but no genetic etiology is seen in >50% of cases.

  18. Dipole response in 208Pb within a self-consistent multiphonon approach

    Science.gov (United States)

    Knapp, F.; Lo Iudice, N.; Veselý, P.; Andreozzi, F.; De Gregorio, G.; Porrino, A.

    2015-11-01

    Background: The electric dipole strength detected around the particle threshold and commonly associated with the pygmy dipole resonance offers unique information on neutron skin and symmetry energy, and is of astrophysical interest. The nature of such a resonance is still under debate. Purpose: We intend to describe the giant and pygmy resonances in 208Pb by enhancing their fragmentation with respect to the random-phase approximation. Method: We adopt the equation of motion phonon method to perform a fully self-consistent calculation in a space spanned by one-phonon and two-phonon basis states using an optimized chiral two-body potential. A phenomenological density-dependent term, derived from a contact three-body force, is added to get single-particle spectra more realistic than the ones obtained by using the chiral potential only. The calculation takes into full account the Pauli principle and is free of spurious center-of-mass admixtures. Results: We obtain a fair description of the giant resonance and obtain a dense low-lying spectrum in qualitative agreement with the experimental data. The transition densities as well as the phonon and particle-hole composition of the most strongly excited states support the pygmy nature of the low-lying resonance. Finally, we obtain realistic values for the dipole polarizability and the neutron skin radius. Conclusions: The results emphasize the role of the two-phonon states in enhancing the fragmentation of the strength in the giant resonance region and at low energy, consistently with experiments. For a more detailed agreement with the data, the calculation suggests the inclusion of the three-phonon states as well as a fine tuning of the single-particle spectrum to be obtained by a refinement of the nuclear potential.

  19. MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1.

    Science.gov (United States)

    Sun, Xin; Jiang, Shiwen; Liu, Jian; Wang, Huangzhen; Zhang, Yiwen; Tang, Shou-Ching; Wang, Jichang; Du, Ning; Xu, Chongwen; Wang, Chenguang; Qin, Sida; Zhang, Jia; Liu, Dapeng; Zhang, Yunfeng; Li, Xiaojun; Wang, Jiansheng; Dong, Jun; Wang, Xin; Xu, Shaohua; Tao, Zhen; Xu, Fei; Zhou, Jie; Wang, Tao; Ren, Hong

    2015-10-20

    MiR-208a stimulates cardiomyocyte hypertrophy, fibrosis and β-MHC (β-myosin heavy chain) expression, being involved in cardiovascular diseases. Although miR-208a is known to play a role in cardiovascular diseases, its role in cancer and cancer stem cells (CSCs) remains uncertain. We identified an inverse relationship between miR-208a and let-7a in breast cancer specimens, and found that SOX2, β-catenin and LIN28 are highly expressed in patients with advanced breast cancer opposed to lesser grades. Further, we isolated ALDH1+ CSCs from ZR75-1 and MDA-MB-231 (MM-231) breast cancer cell lines to test the role of miR-208a in breast CSCs (BrCSCs). Our studies showed that overexpression of miR-208a in these cells strongly promoted the proportion of ALDH1+ BrCSCs and continuously stimulated the self-renewal ability of BrCSCs. By using siRNAs of SOX2 and/or β-catenin, we found that miR-208a increased LIN28 through stimulation of both SOX2 and β-catenin. The knockdown of either SOX2 or β-catenin only partially attenuated the functions of miR-208a. Let-7a expression was strongly inhibited in miR-208a overexpressed cancer cells, which was achieved by miR-208a induction of LIN28, and the restoration of let-7a significantly inhibited the miR-208a induction of the number of ALDH1+ cells, inhibiting the propagations of BrCSCs. In let-7a overexpressed ZR75-1 and MM-231 cells, DICER1 activity was significantly inhibited with decreased miR-208a. Let-7a failed to decrease miR-208a expression in ZR75-1 and MM-231 cells with DICER1 knockdown. Our research revealed the mechanisms through which miR-208a functioned in breast cancer and BrCSCs, and identified the miR-208a-SOX2/β-catenin-LIN28-let-7a-DICER1 regulatory feedback loop in regulations of stem cells renewal.

  20. γ strength function and level density of 208Pb from forward-angle proton scattering at 295 MeV

    Science.gov (United States)

    Bassauer, S.; von Neumann-Cosel, P.; Tamii, A.

    2016-11-01

    Background: γ strength functions (GSFs) and level densities (LDs) are essential ingredients of statistical nuclear reaction theory with many applications in astrophysics, reactor design, and waste transmutation. Purpose: The aim of the present work is a test of systematic parametrizations of the GSF recommended by the RIPL-3 database for the case of 208Pb. The upward GSF and LD in 208Pb are compared to γ decay data from an Oslo-type experiment to examine the validity of the Brink-Axel (BA) hypothesis. Methods: The E 1 and M1 parts of the total GSF are determined from high-resolution forward angle inelastic proton scattering data taken at 295 MeV at the Research Center for Nuclear Physics (RCNP), Osaka, Japan. The total LD in 208Pb is derived from the 1- LD extracted with a fluctuation analysis in the energy region of the isovector giant dipole resonance. Results: The E 1 GSF is compared to parametrizations recommended by the RIPL-3 database showing systematic deficiencies of all models in the energy region around neutron threshold. The new data for the poorly known spin-flip M 1 resonance call for a substantial revision of the model suggested in RIPL-3. The total GSF derived from the present data is larger in the PDR energy region than the Oslo data but the strong fluctuations due to the low LD resulting from the double shell closure of 208Pb prevent a conclusion on a possible violation of the BA hypothesis. Using the parameters suggested by RIPL-3 for a description of the LD in 208Pb with the back-shifted Fermi gas model, remarkable agreement between the two experiments spanning a wide excitation energy range is obtained. Conclusions: Systematic parametrizations of the E 1 and M 1 GSF parts need to be reconsidered at low excitation energies. The good agreement of the LD provides an independent confirmation of the approach underlying the decomposition of GSF and LD in Oslo-type experiments.

  1. Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried Cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Xu Yan

    2016-09-01

    Full Text Available Background/Aims: Ginsenoside Rb1 (GS-Rb1 is one of the most important active pharmacological extracts of the Traditional Chinese Medicine ginseng, with extensive evidence of its cardioprotective properties. Mir-208 has been shown to act as a biomarker of acute myocardial infarction in vivo studies including man. However the impact of miR-208 on the protective effect of GS-Rb1 in hypoxia/ischemia injured cardiomyocytes remains unclear. The current study aims to investigate the target gene of miR-208 and the impact on the protective effect of GS-Rb1 in hypoxia/ischemia (H/I injuried cardiomyocytes. Materials and Methods: Primary cultures of neonatal rat cardiomyocytes (NRCMs was subjected to the H/I conditions with or without GS-Rb1. Cell viability was calculated by MTT assay and confirmed by flow cytometry analysis. Mir-208 was then detected by qRT-PCR. Luciferase reporter assay was carried out to detect the target gene of Mir-208. Then the NRCMs were transfected with miR-208 mimics and inhibitors to evaluate the impact on cardioprotective properties of Rb1. Results: The miR-208 expression level was clearly upregulated in the H/I treated NRCMs accompanied by the percentage of the apoptotic cells which could be reversed by GS-Rb1 pretreatment. The nemo-like kinase (NLK mRNA and protein expression levels were decreased in H/I group measured by RT-PCR and western blotting. Luciferase activity assay was then carried out to identify that NLK may be a direct target of mir-208. MTT assay showed that miR-208 inhibitor slightly decreased the protective effect of Rb1 on the H/I impaired NRCMs. However, results showed no statistical difference. Conclusions: These findings proved that NLK was a direct target of mir-208 and miR-208 act indirectly during Rb1 protecting H/I impaired NRCMs and further researches were needed to explore the relationship that microRNAs and other signal pathways in the protective effect of GS-Rb1 on the hypoxia/ischemia injuries in

  2. microRNA-208a in an early stage myocardial infarction rat model and the effect on cAMP-PKA signaling pathway.

    Science.gov (United States)

    Feng, Gao; Yan, Zhang; Li, Chuanchuan; Hou, Yuemei

    2016-08-01

    The expression level of microRNA-208a (miR-208a) in a rat model with myocardial infarction and the effect of cAMP-PKA signaling pathway in early stage of myocardial infarction in rats were investigated. The early myocardial infarction model was established in 12 male Sprague-Dawley rats by ligation of the anterior descending coronary artery, and 12 rats were selected as the control group (sham operation group). Reverse-transcription quantitative PCR was conducted to detect the expression levels of miR-208a in the myocardium of and the expression levels of miR‑208a in the serum of rats in the two groups. Western blot analysis was used to evaluate the expression levels of cAMP-PKA protein in the rat tissues in the two groups. After stimulating high levels of miR‑208a expression in human myocardial cells (HCM), western blot analysis was used to detect the cAMP-PKA protein levels. The expression levels of miR‑208a in myocardial tissues in rats with myocardial infarction were significantly higher than those in the control group, and the difference was statistically significant (PcAMP-PKA protein in myocardial tissue in rats with chronic myocardial infarction was also significantly higher. Transfection of human myocardial cells with miR‑208a analogue significantly increased the cAMP-PKA protein levels in human myocardial cells. In conclusion, the over-expression of miR-208a in myocardial infarction tissue and the high levels of this miRNA in the serum, may be involved in the process of myocardial infarction by influencing the cAMP-PKA signaling pathway in myocardial cells.

  3. Neutron scattering from 208Pb at 30.4 and 40.0 MeV and isospin dependence of the nucleon optical potential

    CERN Document Server

    DeVito, R P; Austin, Sam M; Berg, U E P; Loc, Bui Minh

    2012-01-01

    Analysis of data involving nuclei far from stability often requires optical potential (OP) for neutron scattering. Since neutron data is seldom available, while proton scattering data is more abundant, it is useful to have estimates of the difference of the neutron and proton optical potentials. This information is contained in the isospin dependence of the nucleon OP. Here we attempt to provide it for the nucleon-208Pb system. The goal of this paper is to obtain accurate n+208Pb scattering data, and use it, together with existing p+208Pb and 208Pb(p,n)208$Bi*_{IAS} data, to obtain an accurate estimate of the isospin dependence of the nucleon OP at energies in the 30-60 MeV range. Cross sections for n+208Pb scattering were measured at 30.4 and 40.0 MeV, with a typical relative (normalization) accuracy of 2-4% (3%). An angular range of 15 to 130 degrees was covered using the beam-swinger time of flight system at Michigan State University. These data were analyzed by a consistent optical model study of the neut...

  4. Eicosanoids mediate sHSP 20.8 gene response to biotic stress in larvae of the Chinese oak silkworm Antheraea pernyi.

    Science.gov (United States)

    Zhang, Cong-Fen; Dai, Li-Shang; Wang, Lei; Qian, Cen; Wei, Guo-Qing; Li, Jun; Zhu, Bao-Jian; Liu, Chao-Liang

    2015-05-10

    Small heat shock proteins (sHSPs) can regulate protein folding and protect cells from stress. To investigate the role of sHSPs in the silk-producing insect Antheraea pernyi (A. pernyi; Lepidoptera: Saturniidae), cDNA encoding HSP20.8 in A. pernyi, termed Ap-sHSP20.8, was identified as a 564 bp ORF. The translated amino acid sequence encoded 187 residues with a calculated molecular mass of 20.8 kDa and an isoelectronic point (pI) of 5.98; the sequence showed homology to sHSP chaperone proteins from other insects. Ap-sHSP20.8 mRNA transcript expression was abundant in the midgut and fat body and found to be both constitutive and inducible by infectious stimuli. Therefore, Ap-sHSP20.8 may play important roles in A. pernyi immune responses under biotic stress. Furthermore, we found that eicosanoids could mediate the induction of Ap-sHSP20.8 in the fat body and midgut. Our findings show that sHSPs may be promising molecules to target in order to cripple immunity in insect pests.

  5. Preterm Premature Rupture of Membranes in Late Incomplete Pregnancy:Clinical Records of 208 Cases%妊娠晚期未足月胎膜早破208例临床分析

    Institute of Scientific and Technical Information of China (English)

    宋美兰; 贾艳艳

    2011-01-01

    目的 探讨妊娠晚期未足月胎膜早破患者的治疗及妊娠结局.方法 对2006年1月~2010年12月在河南省商丘市妇幼保健院住院分娩的208例妊娠晚期未足月胎膜早破患者的临床资料进行回顾性分析.结果 生殖道炎症和胎位异常是胎膜早破发生的主要诱因,但大部分患者原因不明;妊娠晚期未足月胎膜早破患者经保胎治疗75.48%(157/208)的患者于48 h后分娩,为应用糖皮质激素促胎肺成熟争取了时间;25.48%(53/208)的患者以剖宫产结束妊娠,主要手术指征为骨盆因素及胎儿窘迫,因未足月胎儿相对较小,大部分患者可阴道分娩;胎龄28~31周的早产儿因发育不成熟等因素死亡率较高.结论 妊娠晚期未足月胎膜早破的发生对孕产妇和围产儿的影响较大.胎膜早破与胎位异常、生殖道感染等关系密切,胎膜早破的分娩时机及分娩方式的选择原则上应根据胎儿所处危险的大小来决定,抗生素和糖皮质激素的应用可改善新生儿的结局.%Objective To study the treatment and the pregnancy outcome of patients with preterm premature rupture of membranes(PPROM)in late pregnancy. Methods The clinic data of 208 cases of PPROM in late pregnancy were retrospectively analyzed. Results The genital tract inflammation and abnormal fetal position were the major cause of PPROM, but most patients had unknown reasons. 75.48% of the third trimester patients with PPROM(157/208)gave birth after 48 h,and were given glucocorticoids treatment to promote fetal lung maturation, 25.48 % ( 53/208) patients received cesarean section for termination of pregnancy. Most patients were subjected to vaginal delivery. The fetuses with 28 to 31 weeks gestational age had a higher mortality. Conclusion PPROM in the late pregnancy has a great impact on pregnant women and infants. Fetal anomalies and reproductive tract infections are closely related to PPROM. The delivery timing and mode of delivery

  6. 4L-20/8空气压缩机智能化控制技术及应用实践%The Intelligent Control Technology and Practical Application of the 4L-20/8 Air Compressor

    Institute of Scientific and Technical Information of China (English)

    苏震; 刘秋杰

    2013-01-01

    The article analysis the 4L-20/8 air compressor operation condition,made the practical air and the compressed air dynamic matching,realized the motor speed stepless adjustment,stop the motor under no-load running,and made gas production as improved conditions for intelligent control of air compressors.Intelligent control method use the computer-controlled management system,using a set of intelligent control systems to drive multiple 4L-20/8 air compressor to achieve a drag and more control,and install a pressure sensor in the tank pressure pipe,then control the regulation of air compressors.The success of the intelligent control transformation of the 4L-20/8 air compressor system is very important and has a broad application prospect,which provides a new means for enterprises to save energy and improve economic efficiency for the type of energy to run the air compressor.%通过分析4L-20/8空气压缩机的运行工况,使用气量与压气量动态匹配,实现电动机转速无级调节,防止电动机在空载下运行,并将用产气量作为改进空气压缩机智能化控制的条件。智能化控制方法利用微机控制管理系统,用一套智能化控制系统驱动多台4L-20/8空气压缩机,进行一拖多控制,在储气罐的压力管道上安装压力传感器,实现对空气压缩机的控制与调节。通过对4L-20/8空气压缩机进行智能化控制,可以降低能源消耗,减少设备的维修保养工作量,从而实现空气压缩机无人值守自动运行。该系统改造的成功,为此类型空气压缩机的节能运行提供了新手段,对于企业节能降耗,提高企业经济效益有重要意义,有广阔的推广应用前景。

  7. 208例上消化道出血患者的病因分析及胃镜诊断体会%Analysis of etiology and endoscopic diagnosis in 208 cases of upper gastrointestinal bleeding

    Institute of Scientific and Technical Information of China (English)

    谢艳英; 韩敏

    2012-01-01

    Objective To investigate the causes of 208 cases of upper gastrointestinal bleeding and evaluate the value of gastroscopy on the diagnosis. Methods Retrospectively analyzed 208 cases of upper gastrointestinal bleeding received gastroscopy in our hospital from Jun. 2010 to Jun. 2012. Results Peptic ulcer was a major cause of upper gastrointestinal bleeding in different age groups, the rate of peptic ulcer bleeding in young-middle-aged group (42.4% ) was higher than that in elderly group (27.7%, P <0. 05). Gastrointestinal tumor was a common cause of upper gastrointestinal bleeding in the elderly, the rate of gastrointestinal tumor bleeding in elderly group (23. 7% ) was higher than that in the young-middle-aged group (7. 6%, P < 0. 01). The correct diagnosis rate by emergency gastroscopy was 97. 5% , higher than that in the non-emergency gastroscopy (87.5% , P<0.05). Conclusion Peptic ulcer is the main cause of upper gastrointestinal bleeding. Emergency gastroscopy can be the primary method on the diagnosis of upper gastrointestinal bleeding.%目的 对208例上消化道出血患者的病因进行分析,探讨胃镜的诊断价值.方法 回顾性分析我院2010年6月-2012年6月收治的208例上消化道出血患者胃镜诊断结果.结果 消化性溃疡是不同年龄组上消化道出血的主要病因,中青年组消化性溃疡出血比率(42.4%)高于老年组(27.7%,P<0.05).消化道肿瘤在老年组上消化道出血中所占的比例为23.7%,明显高于中青年组的7.6%(P<0.01),是老年人上消化道出血的常见原因.急诊胃镜组病因检出率为97.5%,高于非急诊胃镜组的87.5%(P<0.05).结论 上消化道出血的病因较多,以消化性溃疡最为常见.胃镜对上消化道出血病因诊断有较高价值,可作为首选方法.

  8. The roles of bacterial biofilm and oxidizing enzymes in the biodegradation of plastic by the bacterium Rhodococcus ruber (C208)

    Science.gov (United States)

    Sivan, A.; Gilan, I.; Santo, M.

    2011-12-01

    Synthetic polymers such as polyethylene are amongst the most durable plastic materials and, therefore are resistant to natural biodegradation resulting in their accumulation in the environment posing a global hazard. We have carried out a two-step enrichment procedure aimed at the isolation of polyethylene-degrading bacteria from soil. The initial enrichment was carried out in soil and the second, in a liquid mineral medium supplemented with linear low-density polyethylene (LDPE; MW 191,000) as the sole carbon source. UV-photooxidation may enhance biodegradation by the formation of carbonyl residues that can be utilized by microorganisms. This screening gave rise to several bacterial strains that were capable of degrading polyethylene. One of these strains (C208), identified as the actinomycete Rhodococcus ruber, colonized the polyethylene producing a biofilm which eventually lead to the degradation of the polyethylene. Adherence and colonization of planktonic C208 cells to the polyethylene surface occurred within minutes from exposure to the polyolefin. This resulted in formation of an initial biofilm that differentiated into cell-aggregation-forming microcolonies. Further organization yielded three-dimensional sessile structures as the mature biofilm. The ratio between the population densities, of the biofilm and planktonic, was about 60:1, indicating a high preference for the biofilm mode of growth. Analysis of the extra-cellular polymeric substances (EPS) in the biofilm of C208 revealed that the polysaccharides level was up to 2.5 folds higher than that of the protein. Surprisingly, the EPS also contained DNA that is actively excreted from live bacterial cells. This is supported by the reduction in biofilm content (but not in viability) following addition, of DNase 1 and RNAse A. The biofilm showed a high viability even after 60 days of incubation in a carbon free medium. This durability of the biofilm, can be attributed to biodegradation of polyethylene. A

  9. Measurement of the Neutron Radius of 208Pb Through Parity Violation in Electron Scattering

    Energy Technology Data Exchange (ETDEWEB)

    Saenboonruang, Kiadtisak [Univ. of Virginia, Charlottesville, VA (United States)

    2013-05-01

    In contrast to the nuclear charge densities, which have been accurately measured with electron scattering, the knowledge of neutron densities still lack precision. Previous model-dependent hadron experiments suggest the difference between the neutron radius, Rn, of a heavy nucleus and the proton radius, Rp, to be in the order of several percent. To accurately obtain the difference, Rn-Rp, which is essentially a neutron skin, the Jefferson Lab Lead (208Pb) Radius Experiment (PREX) measured the parity-violating electroweak asymmetry in the elastic scattering of polarized electrons from 208Pb at an energy of 1.06 GeV and a scattering angle of 5° . Since Z0 boson couples mainly to neutrons, this asymmetry provides a clean measurement of Rn with respect to Rp. PREX was conducted at the Jefferson lab experimental Hall A, from March to June 2010. The experiment collected a final data sample of 2x 107 helicity-window quadruplets. The measured parity-violating electroweak asymmetry APV = 0.656 ± 0.060 (stat) ± 0.014 (syst) ppm corresponds to a difference between the radii of the neutron and proton distributions, Rn-Rp = 0.33+0.16-0.18 fm and provides the first electroweak observation of the neutron skin as expected in a heavy, neutron-rich nucleus. The value of the neutron radius of 208Pb has important implications for models of nuclear structure and their application in atomic physics and astrophysics such as atomic parity non-conservation (PNC) and neutron stars.

  10. [Transfection of hypertrophic cardiac myocytes in vitro with (99)Tc(m)-labeled antisense miR208b oligonucleotide].

    Science.gov (United States)

    Wang, Jing; Feng, Huijuan; Ou, Yangwei; Sun, Yungang; Wu, Juqing; Chen, Pan

    2015-08-01

    To test the efficiency of transfecting (99)Tc(m)-labeled anti-miR208b oligonucleotide into early hypertrophic cardiac myocytes in vitro. The anti-oligonucleotide targeting miR208b (AMO) was synthesized and modified with LNA followed by conjugation with N-hydroxysuccinimidyl S-acetyl-meraptoacetyl triglycine (NHS-MAG3) and radiolabeling with (99)Tc(m). NHS-MAG3-LNA-AMO and labeled AMO were purified with Sep-Pak C18 column chromatography, and the former was examined for UV absorption at the 260 nm using Gene Quant DNA/RNA calculator. The labeling efficiency, radiochemical purity, stability and molecular hybridization activity were analyzed. An angiotensin II-induced cell model of hypertrophic cardiac myocytes was transfected with (99)Tc(m)-NHS-MAG3-LNA-AMO via liposome, and the relative expression of miRNA208b and retention ratio of the labeled AMO in early hypertrophic cells were determined. The labeling efficiency and radiochemical purity of the labeled AMO after purification exceeded 84% and 86%, respectively. The radio- chemical purities of the labeled AMO incubated in serum and normal saline for 12 h were both higher than 80%, and the labeled AMO showed a capacity to hybridize with the target gene. In the hypertrophic model of cardiac myocytes, the retention ratio of labeled AMO at 6 h was higher than 20%. The (99)Tc(m)-labeled antisense probe can be efficiently transfected into hypertrophic cardiac myocytes in vitro, which provides an experimental basis for subsequent radionuclide imaging studies.

  11. Arginine 199 and leucine 208 have key roles in the control of adenosine A2A receptor signalling function.

    Directory of Open Access Journals (Sweden)

    Nicolas Bertheleme

    Full Text Available One successful approach to obtaining high-resolution crystal structures of G-protein coupled receptors is the introduction of thermostabilising mutations within the receptor. This technique allows the generation of receptor constructs stabilised into different conformations suitable for structural studies. Previously, we functionally characterised a number of mutants of the adenosine A2A receptor, thermostabilised either in an agonist or antagonist conformation, using a yeast cell growth assay and demonstrated that there is a correlation between thermostability and loss of constitutive activity. Here we report the functional characterisation of 30 mutants intermediate between the Rag23 (agonist conformation mutant and the wild-type receptor using the same yeast signalling assay with the aim of gaining greater insight into the role individual amino acids have in receptor function. The data showed that R199 and L208 have important roles in receptor function; substituting either of these residues for alanine abolishes constitutive activity. In addition, the R199A mutation markedly reduces receptor potency while L208A reduces receptor efficacy. A184L and L272A mutations also reduce constitutive activity and potency although to a lesser extent than the R199A and L208A. In contrast, the F79A mutation increases constitutive activity, potency and efficacy of the receptor. These findings shed new light on the role individual residues have on stability of the receptor and also provide some clues as to the regions of the protein responsible for constitutive activity. Furthermore, the available adenosine A2A receptor structures have allowed us to put our findings into a structural context.

  12. Study of the elastic scattering of {sup 6}He on {sup 208}Pb at energies around the Coulomb barrier

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Benitez, A.M. [Departamento de Fisica Aplicada, Universidad de Huelva, E-21071 Huelva (Spain); Centre de Recherches du Cyclotron, Universite Catholique de Louvain, B-1348 Louvain-la-Neuve (Belgium); Escrig, D. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); Alvarez, M.A.G.; Andres, M.V. [Departamento de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, E-41080 Sevilla (Spain); Angulo, C. [Centre de Recherches du Cyclotron, Universite Catholique de Louvain, B-1348 Louvain-la-Neuve (Belgium); Borge, M.J.G. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); Cabrera, J. [Centre de Recherches du Cyclotron, Universite Catholique de Louvain, B-1348 Louvain-la-Neuve (Belgium); Cherubini, S. [INFN Laboratori Nazionali del Sud, I-95123 Catania (Italy); Demaret, P. [Centre de Recherches du Cyclotron, Universite Catholique de Louvain, B-1348 Louvain-la-Neuve (Belgium); Espino, J.M. [Dept. de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, E-41080 Sevilla (Spain); Figuera, P. [INFN Laboratori Nazionali del Sud, I-95123 Catania (Italy); Freer, M. [School of Physics and Astronomy, University of Birmingham, B15 2TT Birmingham (United Kingdom); Garcia-Ramos, J.E. [Departamento de Fisica Aplicada, Universidad de Huelva, E-21071 Huelva (Spain); Gomez-Camacho, J. [Dept. de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, E-41080 Sevilla (Spain); Gulino, M. [INFN Laboratori Nazionali del Sud, I-95123 Catania (Italy); Kakuee, O.R. [Van der Graaff Laboratory, Nuclear Research Centre, AEOI, PO Box 14155-1339, Tehran (Iran, Islamic Republic of); Martel, I. [Dept. de Fisica Aplicada, Universidad de Huelva, E-21071 Huelva (Spain)], E-mail: imartel@uhu.es; Metelko, C. [School of Physics and Astronomy, University of Birmingham, B15 2TT Birmingham (United Kingdom); Moro, A.M. [Dept. de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, E-41080 Sevilla (Spain)] (and others)

    2008-04-15

    The elastic scattering of {sup 6}He on {sup 208}Pb has been measured at laboratory energies of 14, 16, 18 and 22 MeV. These data were analyzed using phenomenological Woods-Saxon form factors and optical model calculations. A semiclassical polarization potential was used to study the effect of the Coulomb dipole polarizability. Evidence for long range absorption, partially arising from Coulomb dipole polarizability, is reported. The energy variation of the optical potential was found to be consistent with the dispersion relations which connect the real and imaginary parts of the potential.

  13. Doubly magic 208Pb: High-spin states, isomers, and E 3 collectivity in the yrast decay

    Science.gov (United States)

    Broda, R.; Janssens, R. V. F.; Iskra, Ł. W.; Wrzesinski, J.; Fornal, B.; Carpenter, M. P.; Chiara, C. J.; Cieplicka-Oryńczak, N.; Hoffman, C. R.; Kondev, F. G.; Królas, W.; Lauritsen, T.; Podolyak, Zs.; Seweryniak, D.; Shand, C. M.; Szpak, B.; Walters, W. B.; Zhu, S.; Brown, B. A.

    2017-06-01

    Yrast and near-yrast levels up to spin values in excess of I =30 ℏ have been delineated in the doubly magic 208Pb nucleus following deep-inelastic reactions involving 208Pb targets and, mostly, 430-MeV 48Ca and 1440-MeV 208Pb beams. The level scheme was established up to an excitation energy of 16.4 MeV, based on multifold γ-ray coincidence relationships measured with the Gammasphere array. Below the well-known, 0.5-μs 10+ isomer, ten new transitions were added to earlier work. The delineation of the higher parts of the level sequence benefited from analyses involving a number of prompt- and delayed-coincidence conditions. Three new isomeric states were established along the yrast line with Iπ=20- (10 342 keV), 23+ (11 361 keV), and 28- (13 675 keV), and respective half-lives of 22(3), 12.7(2), and 60(6) ns. Gamma transitions were also identified preceding in time the 28- isomer; however, only a few could be placed in the level scheme and no firm spin-parity quantum numbers could be proposed. In contrast, for most states below this 28- isomer, firm spin-parity values were assigned, based on total electron-conversion coefficients, deduced for low-energy (work remains particularly challenging to explain. Large-scale shell-model calculations were performed with two approaches, a first one where the 1, 2, and 3 particle-hole excitations do not mix with one another, and another more complex one, in which such mixing takes place. The calculated levels were compared with the data and a general agreement is observed for most of the 208Pb level scheme. At the highest spins and energies, however, the correspondence between theory and experiment is less satisfactory and the experimental yrast line appears to be more regular than the calculated one. This regularity is notable when the level energies are plotted versus the I (I +1 ) product and the observed, nearly linear, behavior was considered within a simple "rotational" interpretation. Within this approximate picture

  14. Study of the γ decay of high-lying states in 208Pb via inelastic scattering of 17O ions

    Directory of Open Access Journals (Sweden)

    Crespi F.C.L.

    2014-03-01

    Full Text Available A measurement of the high-lying states in 208Pb has been made using 17O beams at 20 MeV/u. The gamma decay following inelastic excitation was measured with the detector system AGATA Demonstrator based on segmented HPGe detectors, coupled to an array of large volume LaBr3:Ce scintillators and to an array of Si detectors. Preliminary results in comparison with (γ,γ’ data, for states in the 5-8 MeV energy interval, are presented.

  15. Response function of the magnetic spectrometer PRISMA for the multinucleon transfer reaction {sup 40}Ar+{sup 208}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Mijatovic, T.; Szilner, S.; Corradi, L.; Courtin, S.; Farnea, E.; Fioretto, E.; Gadea, A.; Goasduff, A.; Haas, F.; Jelavic-Malenica, D.; Lunardi, S.; Mengoni, D.; Montagnoli, G.; Montanari, D.; Pollarolo, G.; Recchia, F.; Sahin, E.; Scarlassara, F.; Soic, N.; Stefanini, A. M. [Ruder Boskovic Institute, Zagreb (Croatia); INFN, Laboratori Nazionali di Legnaro, Legnaro (Italy); IPHC, CNRS-IN2P3, Universite de Strasbourg, Strasbourg (France); and others

    2012-10-20

    Multinucleon transfer reaction {sup 40}Ar+{sup 208}Pb has been investigated with the PRISMA-CLARA experimental setup in LNL, INFN, Italy. The experimental differential cross sections have been obtained for different transfer channels by measuring more than {Delta}{theta}{sub lab} = 20 Degree-Sign covered by three angular settings of PRISMA. Results have been compared with the semiclassical calculation GRAZING. Since the understanding of the reaction mechanism depends strongly on the determination of absolute cross section, effect of transport of ions through PRISMA has been studied via a Monte Carlo simulation code.

  16. Study of the cross section determination with the PRISMA spectrometer: The {sup 40}Ar + {sup 208}Pb case

    Energy Technology Data Exchange (ETDEWEB)

    Mijatovic, T.; Szilner, S.; Jelavic Malenica, D.; Soic, N. [Ruder Boskovic Institute, Zagreb (Croatia); Corradi, L.; Fioretto, E.; Goasduff, A.; Stefanini, A.M.; Valiente-Dobon, J.J. [INFN, Laboratori Nazionali di Legnaro, Legnaro (Italy); Montanari, D.; Montagnoli, G.; Scarlassara, F. [Padova Univ. (Italy); INFN, Padova (Italy); Pollarolo, G. [Torino Univ. (Italy); INFN, Torino (Italy); Gadea, A. [CSIC-Universidad de Valencia, IFIC, Valencia (Spain); Marginean, N.; Ur, C.A. [Horia Hulubei National Institute of Physics and Nuclear Engineering, Bucharest-Magurele (Romania)

    2016-04-15

    The PRISMA spectrometer's response function was successfully applied to match three angular and magnetic settings over a wide angular range for measurements of quasi-elastic reactions in {sup 40}Ar + {sup 208}Pb. The absolute scale of cross sections has been obtained by using the Rutherford cross section at the forward angles and the information from the energy distributions measured with the spectrometer without and with coincidences with the CLARA γ-array. The semi-classical model GRAZING has been used to test the unfolding procedure and for comparison with the corrected cross sections. (orig.)

  17. Excitation of giant monopole resonance in {sup 208}Pb and {sup 116}Sn using inelastic deuteron scattering

    Energy Technology Data Exchange (ETDEWEB)

    Patel, D.; Garg, U. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Joint Institute for Nuclear Astrophysics, University of Notre Dame, Notre Dame, IN 46556 (United States); Itoh, M. [Cyclotron and Radioisotope Center, Tohoku University, Sendai 980-8578 (Japan); Akimune, H. [Department of Physics, Konan University, Kobe 568-8501 (Japan); Berg, G.P.A. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Joint Institute for Nuclear Astrophysics, University of Notre Dame, Notre Dame, IN 46556 (United States); Fujiwara, M. [Research Center for Nuclear Physics, Osaka University, Osaka 567-0047 (Japan); Harakeh, M.N. [Kernfysisch Versneller Instituut, University of Groningen, 9747 AA Groningen (Netherlands); GANIL, CEA/DSM-CNRS/IN2P3, 14076 Caen (France); Iwamoto, C. [Department of Physics, Konan University, Kobe 568-8501 (Japan); Kawabata, T. [Division of Physics and Astronomy, Kyoto University, Kyoto 606-8502 (Japan); Kawase, K. [Japan Atomic Energy Agency, Kyoto 619-0215 (Japan); Matta, J.T. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Joint Institute for Nuclear Astrophysics, University of Notre Dame, Notre Dame, IN 46556 (United States); Murakami, T. [Division of Physics and Astronomy, Kyoto University, Kyoto 606-8502 (Japan); Okamoto, A. [Department of Physics, Konan University, Kobe 568-8501 (Japan); Sako, T. [Japan Atomic Energy Agency, Kyoto 619-0215 (Japan); Schlax, K.W. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Takahashi, F. [Research Center for Nuclear Physics, Osaka University, Osaka 567-0047 (Japan); White, M. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Yosoi, M. [Research Center for Nuclear Physics, Osaka University, Osaka 567-0047 (Japan)

    2014-07-30

    The excitation of the isoscalar giant monopole resonance (ISGMR) in {sup 208}Pb and {sup 116}Sn has been investigated using small-angle (including 0°) inelastic scattering of 100 MeV/u deuteron and multipole-decomposition analysis (MDA). The extracted strength distributions agree well with those from inelastic scattering of 100 MeV/u α particles. These measurements establish deuteron inelastic scattering at E{sub d}∼100 MeV/u as a suitable probe for extraction of the ISGMR strength with MDA, making feasible the investigation of this resonance in radioactive isotopes in inverse kinematics.

  18. Can three-neutron forces be constrained by empirical information on the neutron skin of 48Ca and 208Pb?

    CERN Document Server

    Sammarruca, Francesca

    2016-01-01

    We calculate the neutron matter equation of state from two-neutron forces up to ?fifth order of the chiral expansion and investigate the order-by-order convergence of the predictions. Based on these equations of state, we derive the binding energies and the neutron and proton density distributions in 208Pb and 48Ca, with particular attention to the neutron skins. Anticipating future experiments which will provide reliable information on the weak charge density in nuclei, we discuss the theoretical uncertainties and the possibility of constraining the size of three-neutron forces in neutron matter.

  19. Study of the γ decay of high-lying states in 208Pb via inelastic scattering of 17O ions

    Science.gov (United States)

    Crespi, F. C. L.; Kmiecik, M.; Bracco, A.; Leoni, S.; Maj, A.; Benzoni, G.; Blasi, N.; Boiano, C.; Bottoni, S.; Brambilla, S.; Camera, F.; Ceruti, S.; Giaz, A.; Million, B.; Morales, A. I.; Nicolini, R.; Pellegri, L.; Riboldi, S.; Vandone, V.; Wieland, O.; Bednarczyk, P.; Ciemala, M.; Grebosz, J.; Krzysiek, M.; Mazurek, K.; Zieblinski, M.; Bazzacco, D.; Bellato, M.; Birkenbach, B.; Bortolato, D.; Calore, E.; De Angelis, G.; Farnea, E.; Gadea, A.; Görgen, A.; Gottardo, A.; Isocrate, R.; Lenzi, S.; Lunardi, S.; Mengoni, D.; Michelagnoli, C.; Molini, P.; Napoli, D. R.; Recchia, F.; Sahin, E.; Siebeck, B.; Siem, S.; Ur, C.; Valiente Dobon, J. J.

    2014-03-01

    A measurement of the high-lying states in 208Pb has been made using 17O beams at 20 MeV/u. The gamma decay following inelastic excitation was measured with the detector system AGATA Demonstrator based on segmented HPGe detectors, coupled to an array of large volume LaBr3:Ce scintillators and to an array of Si detectors. Preliminary results in comparison with (γ,γ') data, for states in the 5-8 MeV energy interval, are presented.

  20. Quantum molecular dynamics approach to estimate spallation yield from + 208Pb reaction at 800 MeV

    Indian Academy of Sciences (India)

    P K Sarkar; Maitreyee Nandy

    2003-10-01

    The spallation yield of neutrons and other mass fragments produced in 800 MeV proton induced reaction on 208Pb have been calculated in the framework of quantum molecular dynamics (QMD) model. The energy spectra and angular distribution have been calculated. Also, multiplicity distributions of the emitted neutrons and kinetic energy carried away by them have been estimated and compared with the available experimental data. The agreement is satisfactory. A major contribution to the neutron emission comes from statistical decay of the fragments. For mass and charge distributions of spallation productsthe QMD process gives rise to target-like and projectile-like fragments only.

  1. Long range absorption in the scattering of He-6 on Pb-208 and Au-197 at 27-MeV

    OpenAIRE

    Kakuee, O. R.; Alvarez, M. A. G.; Andres, M. V.; Cherubini, S.; Davinson, T.; Di Pietro, A.; Galster, W.; Gomez-Camacho, J.; Laird, A M; Lamehi-Rachti, M.; Martel, I.; Moro, A. M.; Rahighi, J.; Sanchez-Benitez, A M; Shotter, A.C.

    2005-01-01

    Quasi-elastic scattering of 6He at E_lab=27 MeV from 197Au has been measured in the angular range of 6-72 degrees in the laboratory system employing LEDA and LAMP detection systems. These data, along with previously analysed data of 6He + 208Pb at the same energy, are analyzed using Optical Model calculations. The role of Coulomb dipole polarizability has been investigated. Large imaginary diffuseness parameters are required to fit the data. This result is an evidence for lo...

  2. Long range absorption in the scattering of 6He on 208Pb and 197Au at 27 MeV

    CERN Document Server

    Kakuee, O R; Andrés, M V; Cherubini, S; Davinson, T; Pietro, A D; Galster, W; Gómez-Camacho, J; Laird, A M; Lamehi-Rachti, M; Martel, I; Moro, A M; Rahighi, J; Sanchez-Benitez, A M; Shotter, A C; Smith, W B; Vervier, J; Woods, P J

    2006-01-01

    Quasi-elastic scattering of 6He at E_lab=27 MeV from 197Au has been measured in the angular range of 6-72 degrees in the laboratory system employing LEDA and LAMP detection systems. These data, along with previously analysed data of 6He + 208Pb at the same energy, are analyzed using Optical Model calculations. The role of Coulomb dipole polarizability has been investigated. Large imaginary diffuseness parameters are required to fit the data. This result is an evidence for long range absorption mechanisms in 6He induced reactions.

  3. $\\alpha$-particle production in the scattering of 6He by 208Pb at energies around the Coulomb barrier

    CERN Document Server

    Escrig, D; Moro, A M; Alvarez, M A G; Andrés, M V; Angulo, C; García-Borge, M J; Cabrera, J; Cherubini, S; Demaret, P; Espino, J M; Figuera, P; Freer, M; García-Ramos, J E; Gómez-Camacho, J; Gulino, M; Kakuee, O R; Martel, I; Metelko, C; Pérez-Bernal, F; Rahighi, J; Rusek, K; Smirnov, D; Tengblad, O; Ziman, V

    2007-01-01

    New experimental data from the scattering of 6He+208Pb at energies around and below the Coulomb barrier are presented. The yield of breakup products coming from projectile fragmentation is dominated by a strong group of $\\alpha$ particles. The energy and angular distributions of this group have been analyzed and compared with theoretical calculations. This analysis indicates that the $\\alpha$ particles emitted at backward angles in this reaction are mainly due to two-neutron transfer to weakly bound states of the final nucleus.

  4. Fusion calculations for 40Ca+40Ca, 48Ca+48Ca, 40Ca+48Ca and p+208Pb systems

    Science.gov (United States)

    Gao, Jie; Zhang, Haifei; Bao, Xiaojun; Li, Junqing; Zhang, Hongfei

    2014-09-01

    The fusion cross sections of calcium isotopes and proton induced fusion have been calculated in terms of a coupled-channels formulation. Results indicated that there are big differences between the two fusion types. In the calculations of calcium isotopes fusion, the pair-transfer coupling has been applied in addition to the vibrational coupling, the combined effects showed that pair-transfer has played a significant role in the fusion process for the asymmetric 40Ca+48Ca system. The result of proton induced fusion for p+208Pb system successfully presents the fusion oscillation, which agrees with the experimental data rather well.

  5. Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF-β receptor I kinase inhibitor (SD-208

    Directory of Open Access Journals (Sweden)

    Abolfazl Akbari

    2015-09-01

    Full Text Available Objective(s:Transforming growth factor-β(TGF-β is involved in colorectal cancer (CRC. The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell line was treated with 0.5, 1 and 2 μM concentrations of SD-208. Then, the xenograft model of colon cancer was established by subcutaneous inoculation of SW-48 cell line into the nude mice. The animals were treated with SD-208 for three weeks. A quantitative real-time PCR was carried out for expression level analysis of selected oncogenic (miR-21, 31, 20a and 135b and suppressor-miRNAs (let7-g, miR-133b, 145 and 200c. Data were analyzed using the 2-∆∆CT method through student’s t-test via the GraphPad Prism software. Results: Our results revealed that SD-208 could significantly down-regulate the expression of one key onco-miRNA, miR-135b, in either SW-48 colon cells (P=0.006 or tumors orthotopically implanted in nude mice (P=0.018. Our in silico study also predicted that SD-208 could modulate the expression of potential downstream tumor suppressor targets of the miR135b. Conclusion: Our data provide novel evidence that anticancer effects of SD-208 (and likely other TGF-β inhibitors may be owing to their ability to regulate miRNAs expression.

  6. Down-regulation of miR-135b in colon adenocarcinoma induced by a TGF-β receptor I kinase inhibitor (SD-208).

    Science.gov (United States)

    Akbari, Abolfazl; Ghahremani, Mohammad Hossein; Mobini, Gholam Reza; Abastabar, Mahdi; Akhtari, Javad; Bolhassani, Manzar; Heidari, Mansour

    2015-09-01

    Transforming growth factor-β (TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell line was treated with 0.5, 1 and 2 μM concentrations of SD-208. Then, the xenograft model of colon cancer was established by subcutaneous inoculation of SW-48 cell line into the nude mice. The animals were treated with SD-208 for three weeks. A quantitative real-time PCR was carried out for expression level analysis of selected oncogenic (miR-21, 31, 20a and 135b) and suppressor-miRNAs (let7-g, miR-133b, 145 and 200c). Data were analyzed using the 2-∆∆CT method through student's t-test via the GraphPad Prism software. Our results revealed that SD-208 could significantly down-regulate the expression of one key onco-miRNA, miR-135b, in either SW-48 colon cells (P=0.006) or tumors orthotopically implanted in nude mice (P=0.018). Our in silico study also predicted that SD-208 could modulate the expression of potential downstream tumor suppressor targets of the miR135b. Our data provide novel evidence that anticancer effects of SD-208 (and likely other TGF-β inhibitors) may be owing to their ability to regulate miRNAs expression.

  7. Identification of the metabolite and cytochrome P450 isoenzymes involved in the rat liver microsomal metabolism of TM208%TM208在大鼠肝微粒体中代谢产物与细胞色素P450亚型代谢酶鉴别研究

    Institute of Scientific and Technical Information of China (English)

    孔德涛; 凌笑梅; 韩方斌; 龚京莉; 葛泽梅; 李润涛; 崔景荣

    2008-01-01

    在大鼠肝微粒体的体外代谢中研究作用于TM208的细胞色素P450亚型代谢酶.以不含细胞色素P450化学抑制剂的样品为对照,研究不同细胞色素P450亚型选择性化学抑制剂对TM208代谢转化率的影响.CYP2D和CYP2B的选择性抑制剂对TM208的代谢表现出浓度依赖性较强抑制作用,CYP1A的选择性抑制剂对TM208的代谢表现出一定抑制作用.CYP3A的选择性抑制剂对TM208的代谢没有表现出明显的抑制作用.TM208在大鼠肝微粒体体外代谢中主要通过CYP2D和CYP2B两种细胞色素P450亚型代谢酶参与代谢.%To identify the metabolite and CYP450 isoforms involved in rat liver microsomal metabolism of TM2O8.The present study investigated the metabolism of TM208 and the effects of selective CYP450 inhibitors on the metabolism of TM208 in rat liver microsomes.Various specific inhibitors of CYP were used to identify the isoforms of CYP involved in the metabolism of TM208.The inhibitor of CYP2D and that of CYP2B had strong inhibitory effects on TM208 metabolism in a concentration-dependant manner,the inhibitor of CYPIA had a modest inhibitory effect,and the inhibitor of CYP3A seemed not to have an obvious inhibitory effect on TM208 metabolism.TM208 might mainly be metabolized by CYP2D and CYP2B in rat liver microsomes.

  8. Constraints on the Neutron Skin and the Symmetry Energy from the Anti-analog Giant Dipole Resonance in 208Pb

    CERN Document Server

    Cao, L G; Colo', G; Sagawa, H

    2015-01-01

    We investigate the impact of the neutron-skin thickness Delta(R) on the energy difference between the anti-analog giant dipole resonance (AGDR), E(AGDR), and the isobaric analog state (IAS), E(IAS), in a heavy nucleus such as 208Pb. For guidance, we first develop a simple and analytic, yet physical, approach based on the Droplet Model that linearly connects the energy difference E(AGDR)-E(IAS) with Delta(R). To test this correlation on more fundamental grounds, we employ a family of systematically varied Skyrme energy density functionals where variations on the value of the symmetry energy at saturation density J are explored. The calculations have been performed within the fully self consistent Hartree-Fock (HF) plus charge-exchange random phase approximation (RPA) framework. We confirm the linear correlation within our microscopic apporach and, by comparing our results with available experimental data in 208Pb, we find that our analysis is consistent with Delta(R) = 0.204 \\pm 0.009 fm, J = 31.4 \\pm 0.5 MeV ...

  9. Tl-208, Pb-212, Bi-212, Ra-226 and Ac-228 adsorption onto polyhydroxyethylmethacrylate-bentonite composite

    Energy Technology Data Exchange (ETDEWEB)

    Akkaya, Recep [Cumhuriyet University, Chemistry Department, 58140 Sivas (Turkey); Ulusoy, Ulvi, E-mail: ulusoy@cumhuriyet.edu.tr [Cumhuriyet University, Chemistry Department, 58140 Sivas (Turkey)

    2012-02-01

    The adsorption of naturally occurring radionuclides ({sup 208}Tl{sup +}, {sup 212}Pb{sup 2+}, {sup 226}Ra{sup 2+}, {sup 212}Bi{sup 3+} and {sup 228}Ac{sup 3+}) onto Polyhydroxyethylmethacrylate-bentonite (PHEMA-B) composite was investigated. Experimentally obtained isotherms were evaluated with reference to Langmuir, Freundlich and Dubinin-Radushkevich (DR) models. The adsorption isotherms were L type of Giles classification proving that PHEMA-B had a high affinity adsorbent for the studied radionuclides. The Langmuir adsorption capacities (X{sub L}) were in the order of {sup 226}Ra (2.8 MBq kg{sup -1})>{sup 212}Bi (0.4 MBq kg{sup -1})>{sup 212}Pb (0.3 MBq kg{sup -1})>{sup 228}Ac and {sup 208}Tl (0.2 MBq kg{sup -1}). The adsorption process was physical via complex formation after proton exchanger for which the adsorption energies obtained from DR model was evidence. The enthalpy and entropy changes were positive and the negative free enthalpy change was proof for the spontaneity of adsorption. The reusability tests for PHEMA-B for five uses demonstrated that the adsorbent could be reused after complete recovery of the loaded radionuclide ions by 1 M HCl. The chemical structure of the composite did not change after the reuses and storage foregoing.

  10. Study of the γ decay of high-lying states in 208Pb via inelastic scattering of 17O ions

    Directory of Open Access Journals (Sweden)

    Crespi F.C.L.

    2012-12-01

    Full Text Available High-lying states in 208Pb nucleus were populated via inelastic scattering of a 17O beam at bombarding energy of 20 MeV/u. Their subsequent gamma decay was measured with the detector system AGATA Demonstrator based on HPGe detectors, coupled to an array of large volume LaBr3:Ce scintillators. Preliminary results in comparison with (γ,γ′ data, for states in the 5–8 MeV energy interval, seem to indicate that in that region the states belong to two different groups one with a isoscalar character and the other with a isovector nature. This is similar to what was observed in other stable nuclei with (α,α′γ experiments. The multipolarity of the observed gamma transitions is determined with remarkable sensitivity thanks to angular distribution measurements. Data aiming at studying the neutron decay of the Giant Quadrupole Resonance in the 208Pb by the high resolution measurement of the following gamma decay are also presented in their preliminary form.

  11. Tl-208, Pb-212, Bi-212, Ra-226 and Ac-228 adsorption onto polyhydroxyethylmethacrylate-bentonite composite

    Science.gov (United States)

    Akkaya, Recep; Ulusoy, Ulvi

    2012-02-01

    The adsorption of naturally occurring radionuclides ( 208Tl +, 212Pb 2+, 226Ra 2+, 212Bi 3+ and 228Ac 3+) onto Polyhydroxyethylmethacrylate-bentonite (PHEMA-B) composite was investigated. Experimentally obtained isotherms were evaluated with reference to Langmuir, Freundlich and Dubinin-Radushkevich (DR) models. The adsorption isotherms were L type of Giles classification proving that PHEMA-B had a high affinity adsorbent for the studied radionuclides. The Langmuir adsorption capacities ( XL) were in the order of 226Ra (2.8 MBq kg -1)> 212Bi (0.4 MBq kg -1)> 212Pb (0.3 MBq kg -1)> 228Ac and 208Tl (0.2 MBq kg -1). The adsorption process was physical via complex formation after proton exchanger for which the adsorption energies obtained from DR model was evidence. The enthalpy and entropy changes were positive and the negative free enthalpy change was proof for the spontaneity of adsorption. The reusability tests for PHEMA-B for five uses demonstrated that the adsorbent could be reused after complete recovery of the loaded radionuclide ions by 1 M HCl. The chemical structure of the composite did not change after the reuses and storage foregoing.

  12. Note on neutron scattering and the optical model near A = 208. [0. 6 to 1. 0 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Guenther, P.; Havel, D.; Smith, A.

    1976-09-01

    Elastic neutron scattering cross sections of /sup 206/Pb, /sup 207/Pb, /sup 208/Pb and /sup 209/Bi are measured at incident neutron energy intervals of approx. 25 keV from 0.6 to 1.0 MeV with resolutions of approx. 25 keV. Optical model parameters are obtained from the energy-averaged experimental results for each of the isotopes. The observed elastic-neutron-scattering distributions and derived parameters for the lead isotopes (doubly magic or neutron holes in the closed shell) tend to differ from those of /sup 209/Bi (doubly closed shell plus a proton). These potentials, derived in the approx. spherical region of A approximately 208, are extrapolated for the analysis of total and scattering cross sections of /sup 238/U introducing only a small N-Z/A dependence and the known deformation of /sup 238/U. Good descriptions of /sup 238/U total cross sections are obtained from a few hundred keV to 10.0 MeV and the prediction of measured scattering distributions in the low MeV region are as suitable as frequently reported with other specially developed potentials.

  13. Analysis of oligomeric transition of silkworm small heat shock protein sHSP20.8 using high hydrostatic pressure native PAGE

    Science.gov (United States)

    Fujisawa, Tetsuro; Ueda, Toshifumi; Kameyama, Keiichi; Aso, Yoichi; Ishiguro, Ryo

    2013-06-01

    The small heat shock proteins (sHSPs) solubilize thermo-denatured proteins without adenosine triphosphate energy consumption to facilitate protein refolding. sHSP20.8 is one of the silkworm (Bombyx mori) sHSPs having only one cystein in the N-terminal domain: Cys43. We report a simple measurement of oligomeric transition of sHSP20.8 using high hydrostatic pressure native polyacrylamide gel electrophoresis (high hydrostatic pressure (HP) native polyacrylamide gel electrophoresis (PAGE)). At ambient pressure under oxydative condition, the native PAGE of thermal transition of sHSP20.8 oligomer displayed a cooperative association. In contrast, HP native PAGE clearly demonstrated that sHSP20.8 dissociated at 80 MPa and 25°C, and the resultant molecular species gradually reassociated with time under that condition. In addition, the reassociation process was suppressed in the presence of the reductant. These results are consistent with the idea that sHSP20.8 oligomer temporally dissociates at the first thermo-sensing step and reassociates with the oxidation of Cys43.

  14. Quasielastic and fission total cross sections for /sup 16/O on /sup 181/Ta and /sup 208/Pb. [80 to 102 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Videbaek, F.; Goldstein, R.B.; Grodzins, L.; Steadman, S.G.; Belote, T.A.; Garrett, J.D.

    1976-01-01

    The total quasielastic (inelastic plus few nucleon transfer) and fission cross sections were measured for /sup 16/O + /sup 208/Pb at incident energies of 80, 83, 88, 90, 96, and 102 MeV and for /sup 16/O + /sup 181/Ta at incident energies of 83, 90 and 96 MeV. The total quasielastic cross sections account for about 50 percent of the total /sup 16/O + /sup 208/Pb reaction cross section at the lowest incident energy which is near the Coulomb barrier. At the highest incident energy the /sup 16/O + /sup 208/Pb quasielastic cross section still accounts for 25 percent of the total cross section. The measured ratio of quasielastic to total cross section for /sup 16/0 + /sup 181/Ta is less than for /sup 16/O + /sup 208/Pb; however, in the case of the /sup 181/Ta target the inelastic transitions to the low lying levels in /sup 181/Ta were not resolved from elastic scattering. Within the uncertainties of the measurements the sum of the measured quasielastic and fission cross sections for /sup 16/O on /sup 208/Pb accounts for the total reaction cross section, indicating that the probability of fission of the /sup 224/Th compound and Th daughter systems is large. In contrast for /sup 16/O + /sup 181/Ta (/sup 197/Tl compound system) the fission and quasielastic channels account for only a small fraction of the total reaction cross section.

  15. Neutron particle-hole electric dipole states in /sup 206/ /sup 207/ /sup 208/Pb. [16. 2 to 17. 8 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Dickey, P.A.

    1979-01-01

    Inelastic proton scattering on /sup 206/Pb, /sup 207/Pb, and /sup 208/Pb through isobaric analog resonances was used to study neutron particle-hole excitations with large ground-state gamma branches in these Pb isotopes. Relative (p,p') cross sections at 90/sup 0/ are extracted for structures selectively excited on the d/sub 5/2/, s/sub 1/2/, and d/sub 3/2/-g/sub 7/2/ resonances. Interpretation of excitations in /sup 206/Pb and /sup 207/Pb in terms of coupling to states in /sup 208/Pb is discussed. Branching ratios for 1/sup -/ states in /sup 208/Pb at 4.84, 5.29, 5.94, and 6.31 MeV and the 1/2/sup +/ state in /sup 207/Pb at 4.63 MeV are deduced. 15 figures, 4 tables.

  16. Multinucleon transfer in O,1816,19F+208Pb reactions at energies near the fusion barrier

    Science.gov (United States)

    Rafferty, D. C.; Dasgupta, M.; Hinde, D. J.; Simenel, C.; Simpson, E. C.; Williams, E.; Carter, I. P.; Cook, K. J.; Luong, D. H.; McNeil, S. D.; Ramachandran, K.; Vo-Phuoc, K.; Wakhle, A.

    2016-08-01

    Background: Nuclear reactions are complex, involving collisions between composite systems where many-body dynamics determines outcomes. Successful models have been developed to explain particular reaction outcomes in distinct energy and mass regimes, but a unifying picture remains elusive. The irreversible transfer of kinetic energy from the relative motion of the collision partners to their internal states, as is known to occur in deep inelastic collisions, has yet to be successfully incorporated explicitly into fully quantal reaction models. The influence of these processes on fusion is not yet quantitatively understood. Purpose: To investigate the population of high excitation energies in transfer reactions at sub-barrier energies, which are precursors to deep inelastic processes, and their dependence on the internuclear separation. Methods: Transfer probabilities and excitation energy spectra have been measured in collisions of O,1816,19F+208Pb , at various energies below and around the fusion barrier, by detecting the backscattered projectile-like fragments in a Δ E -E telescope. Results: The relative yields of different transfer outcomes are strongly driven by Q values, but change with the internuclear separation. In 16O+208Pb , single nucleon transfer dominates, with a strong contribution from -2 p transfer close to the Coulomb barrier, though this channel becomes less significant in relation to the -2 p 2 n transfer channel at larger separations. For 18O+208Pb , the -2 p 2 n channel is the dominant charge transfer mode at all separations. In the reactions with 19F,-3 p 2 n transfer is significant close to the barrier, but falls off rapidly with energy. Multinucleon transfer processes are shown to lead to high excitation energies (up to ˜15 MeV), which is distinct from single nucleon transfer modes which predominantly populate states at low excitation energy. Conclusions: Kinetic energy is transferred into internal excitations following transfer, with this

  17. (. pi. sup +- ,. pi. sup +- prime N) reactions on sup 12 C and sup 208 Pb near the giant resonance region

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Sung Hoon.

    1990-05-01

    Angular distributions for the {sup 12}C({pi}{sup {plus minus}}, {pi}{sup {plus minus}}{prime} p) and {sup 208}Pb({pi}{sup {plus minus}}, {pi}{sup {plus minus}}{prime} p or n) reactions near the giant resonance region have been measured at T{sub {pi}} = 180 MeV, and found different between {pi}{sup +} and {pi}{sup {minus}} data. This observation is interpreted as evidence for different excitation mechanisms dominating the {pi}{sup {minus}}-nucleus and {pi}{sup +}-nucleus interactions in the giant resonance region of these targets. A comparison with the single-nucleon knock-out distorted-wave impulse approximation calculations shows, even though these calculations underestimate ({pi}{sup {plus minus}}, {pi}{sup {plus minus}}{prime} N) data for both targets, the dominance of direct process for ({pi}{sup +}, {pi}{sup {plus}}{prime} p) or ({pi}{sup {minus}}, {pi}{sup {minus}}{prime} n) in contrast to ({pi}{sup {minus}}, {pi}{sup {minus}}{prime} p) or ({pi}{sup +}, {pi}{sup +}{prime} n). In the ({pi}{sup +}, {pi}{sup +}{prime} p) reaction proton-proton hole states are excited directly and appear to have a large probability for direct decay with escape width, whereas in ({pi}{sup {minus}}, {pi}{sup {minus}}{prime} p) the preferentially excited neutron-neutron hole doorway states couple to resonance states and decay with spreading width. This interpretation led us to suggest that the ratio of cross-sections for inelastic scattering to the giant resonance region should be written in terms of an incoherent sum of cross-sections to neutron and proton doorway states. In a heavy nucleus such as {sup 208}Pb, neutron and proton doorway states. In a heavy nucleus such as {sup 208}Pb, neutron and proton doorway states contribute incoherently because the different decay processes do not populate the same final states of the residual nucleus.

  18. Evaporation residue cross sections from complete fusion of {sup 16}O with {sup 197}Au, {sup 208}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Brinkmann, K.T.; Caraley, A.L.; Fineman, B.J. [and others

    1993-04-01

    Fusion-evaporation excitation functions for complete fusion of {sup 16}O with {sup 197}Au and {sup 208}Pb have been measured from the barrier up to excitation energies of about 100 MeV. Using the pulsed {sup 16}O beam from the Stony Brook LINAC, the very slow evaporation residues (ER`s) were separated in an electrostatic deflector system and identified in an array of three surface barrier detectors by their time of flight and energy. While the ER cross sections in the vicinity of the fusion barrier allow the extraction of important statistical model parameters such as fission barrier heights, data at higher excitation energies can yield insight into processes beyond the statistical model regime. The results will be discussed with respect to both aspects.

  19. Extending and refining the mass surface around $^{208}$Pb by high-precision Penning-trap mass spectrometry with ISOLTRAP

    CERN Multimedia

    Herfurth, F; Stora, T; Blaum, K; Beck, D; Kowalska, M; Schwarz, S; Stanja, J; Herlert, A J; Yamaguchi, T

    We propose high-precision mass spectrometry of nuclides around the doubly magic $^{208}$Pb. On the neutron-rich side, we aim to extend the knowledge of Fr, At, Hg, and Au masses to study the robustness of the N = 126 shell closure and to provide mass data necessary for modeling the rapid-neutron-capture process. On the proton-rich side, we aim at high-resolution mass spectrometry of selected Au, At, and Fr isotopes to verify the predicted existence of very low-lying isomeric states. The proposal will make use of newly-available laser-ionization schemes for Au and At. Finally, the recently implemented multi-reflection time-of-flight mass separator for auxiliary isobaric purification now allows measurements which were not feasible before.

  20. Water jet dissection in neurosurgery: an update after 208 procedures with special reference to surgical technique and complications.

    Science.gov (United States)

    Keiner, Doerthe; Gaab, Michael R; Backhaus, Vanessa; Piek, Juergen; Oertel, Joachim

    2010-12-01

    Water jet dissection represents a promising technique for precise brain tissue dissection with preservation of blood vessels. In the past, the water jet dissector has been used for various pathologies. A detailed report of the surgical technique is lacking. The authors present their results after 208 procedures with a special focus on surgical technique, intraoperative suitability, advantages, and disadvantages. Between March 1997 and April 2009, 208 patients with various intracranial neurosurgical pathologies were operated on with the water jet dissector. Handling of the device and its usefulness and extent of application were assessed. The pressures encountered, potential risks, and complications were documented. The patients were followed 1 to 24 months postoperatively. A detailed presentation of the surgical technique is given. Differences and limitations of the water jet dissection device in the various pathologies were evaluated. The water jet dissector was intensively used in 127 procedures (61.1%), intermittently used in 56 procedures (26.9%), and scarcely used in 25 procedures (12%). The device was considered to be very helpful in 166 procedures (79.8%) and helpful to some extent in 33 procedures (15.9%). In 8 (3.8%) procedures, it was not helpful, and in 1 procedure (0.5%), the usefulness was not documented by the surgeon. The water jet dissector can be applied easily and very safely. Precise tissue dissection with preservation of blood vessels and no greater risk of complications are possible. However, the clinical consequences of the described qualities need to be demonstrated in a randomized clinical trial.

  1. 22 CFR 208.300 - What must I do before I enter into a covered transaction with another person at the next lower tier?

    Science.gov (United States)

    2010-04-01

    ... INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 208.300 What must I do before I enter... to do business is not excluded or disqualified. You do this by: (a) Checking the EPLS; or...

  2. Reaction cross sections for protons on {sup 12}C, {sup 40}Ca, {sup 90}Zr and {sup 208}Pb at energies between 80 and 180 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Auce, A.; Ingemarsson, A.; Johansson, R. [and others

    2005-04-01

    Results of reaction cross section measurements on {sup 12}C, {sup 40}Ca, {sup 90}Zr and {sup 208}Pb at incident proton energies between 80 and 180 MeV and for {sup 58}Ni at 81 MeV are presented. The experimental procedure is described and the results are compared with earlier measurements and predictions using macroscopic and microscopic models.

  3. EXCITATION OF GIANT-RESONANCES IN PB-208, SN-120, ZR-90 AND NI-60 BY 84 MEV/NUCLEON O-17 IONS

    NARCIS (Netherlands)

    NETO, RL; ROUSSELCHOMAZ, P; ROCHAIS, L; ALAMANOS, N; AUGER, F; GASTEBOIS, J; GILLIBERT, A; LACEY, R; MICZAIKA, A; PIERROUTSAKOU, D; BARRETTE, J; MARK, SK; TURCOTTE, R; BLUMENFELD, Y; FRASCARIA, N; GARRON, JP; ROYNETTE, JC; SCARPACI, JA; SUOMIJARVI, T; VANDERWOUDE, A; VANDENBERG, AM

    1993-01-01

    Elastic and inelastic scattering of 1435 MeV 170 ions on Pb-208, Sn-120, Zr-90 and Ni-60 have been measured. Hindrance in the excitation of the first 3- states is observed. Parameters of the isoscalar giant monopole and quadrupole resonances are obtained. The quadrupole resonance exhausts approximat

  4. Proton-induced fission at 190 MeV of W-nat, Au-197, Pb-nat, Pb-208, and Th-232

    NARCIS (Netherlands)

    Duijvestijn, MC; Koning, AJ; Beijers, JPM; Gastal, M; van Klinken, J; Ostendorf, RW

    1999-01-01

    Proton-induced fission at 190 MeV of W-nat, Au-197, Pb-nat, Pb-208, and Th-232 is studied by means of an innovative method based on activation analysis. The fission-product mass distribution is reconstructed from the fission-product yields, which are obtained from off-line observed gamma-ray spectra

  5. Isomeric Ratios For Nuclei With Z=62-67 And A=142-152 Produced In The Relativistic Fragmentation Of Pb-208

    OpenAIRE

    Myalski, S.; Maj, A.; Podolyak, Zs; Becker, F.; Bednarczyk, P.(The Niewodniczanski Institute of Nuclear Physics, Krakow, Poland); Benzoni, G.; Blank, B.; Brandau, C; Bruce, A.M.; Caceres, L.; Camera, F.; Catford, W.N.; Cullen, I. J.; Dombradi, Zs.; Doornenbal, P.

    2009-01-01

    Isomeric states in nuclei with Z = 62-67 and A = 142-152 produced in the fragmentation of the relativistic (1 GeV/nucleon) Pb-208 beam were investigated. Isomeric ratios were determined for 10 isomeric states. Significant differences between theoretical and experimental values were observed.

  6. 41 CFR 302-9.208 - If I retain my POV at my post of duty after conditions change to make use of the POV no longer in...

    Science.gov (United States)

    2010-07-01

    ... 302-9.208 Public Contracts and Property Management Federal Travel Regulation System RELOCATION... Government, may I transport it at Government expense from the post of duty at a later date? Yes, your agency... destination, provided you otherwise meet all conditions for transporting a POV....

  7. "You Have to Adapt Because You Have No Other Choice": The Stories of Strength and Resilience of 208 Homeless Youth in New York City and Toronto

    Science.gov (United States)

    Kidd, Sean A.; Davidson, Larry

    2007-01-01

    Presented in this paper are the results of a qualitative analysis of the narratives of 208 homeless youth interviewed on streets and in agencies in New York City and Toronto. The interviews focused on the participants' stories about their struggles to survive and negotiate meaningful and healthy lives in coming to the streets, living on the…

  8. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  9. Isolation of Actinium from Neutron-irradiated Thorium-I

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Isolation of Actinium from Neutron-irradiated Thorium-I¥YangWeifan;YuanShuanggui;MuWantong;ZhangXueqian;LiZhongweiandZhaoLili...

  10. Study of electrostatic discharges under separate and combined radiation of CMG and K-208 glass by electrons and protons

    Science.gov (United States)

    Khasanshin, Rashid; Novikov, Lev

    2016-07-01

    It is known that irradiation of low-conductive dielectric by charged particles which track lengths do not excess the sample dimensions results in formation of areas with high density charge. The field induced by the accumulated charge can initiate the electrostatic discharge between the charge location area and surface of the dielectric. The study of electrostatic discharges in low-conductive dielectrics under radiation is essential both from a scientific point of view and for the solution of applied problems. In particular, interaction of a spacecraft with ambient plasma causes accumulation of electric charges on its surface producing, as a consequence, electric potential between the spacecraft surface and the plasma. Initiation conditions and features of evolution of electrostatic discharges on surface of K-208 glass used as the protective covering of spacecraft solar arrays, under combined irradiation by electrons and protons in vacuum were studied in this work. Energies of electrons and protons were 20-40 keV and 20 keV respectively. The particles beam current was varied within 1.5 ÷ 200 nA. Surfaces of irradiated samples were studied by AFM methods. It was shown that changes of sample morphology due to radiation are determined by radiation annealing of defects in the near-surface layer of the glass, mass transfer processes accompanying by forming various structures on its surface and electrostatic discharges, surface modification having depended on radiation type and intensity. It was ascertained that microprotrusions either presenting on glass surface due to the process of its fabrication or appeared at the early stage of irradiation promotes discharge development. Changes of glass surface morphology due to radiation, as was shown, are stipulated both radiation annealing and electrostatic discharges, surface modification having depended on radiation type and intensity. The observed differences in the development of discharges in the K-208 and CMG glass are

  11. microRNA-208在急性心肌梗死患者外周血中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    史万青; 高明珠; 韩志君

    2015-01-01

    目的:通过分析micro RNA-208在急性心肌梗死(acute myocardial infarction,AMI)患者外周血中含量的变化,探讨micro RNA-208在AMI疾病进展中的作用。方法:连续性收集2013年1月~2013年12月滁州市第一人民医院心血管内科和急诊科收治的急性心肌梗死(AMI)患者42例,不稳定心绞痛(unstable angina,UA)患者22例,健康体检志愿者20名,荧光定量PCR测定外周血micro RNA-208的含量,电化学发光法检测血浆c Tn I和CK-MB的水平。AMI组患者根据不同冠脉病变支数和接受急诊经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗进行分组,对比各组患者外周血micro RNA-208水平的差异。结果:AMI患者外周血micro RNA-208的水平显著高于UA组和健康对照组,差异具有统计学意义(P〈0.01),AMI患者外周血micro RNA-208的水平与血清CTn I含量呈正相关(r=0.700,P=0.000)。24例行冠状动脉造影术的AMI组患者中,micro RNA-208的表达在两支及三支病变中高于单支病变(P〈0.01),17例成功接受急诊PCI治疗的AMI患者,其症状发作后的24h血浆micro RNA-208水平较入院即刻时明显降低(P〈0.01)。结论:心肌细胞特异性的micro RNA-208在心肌梗死后外周血含量明显升高,随着血管狭窄严重程度的升高其浓度也显著变化,可以作为辅助监测急性心肌梗死的敏感的生物学指标。

  12. Diversities in the properties of neutron stars at a fixed neutron-skin thickness in $^{208}$Pb nucleus

    CERN Document Server

    Alam, N; Agrawal, B K

    2015-01-01

    We study the diversities in the properties of the neutron stars arising due to the different choices for the cross-coupling between various mesons which governs the density dependence of the nuclear symmetry energy in the extended relativistic mean-field(RMF) model. For this purpose, we obtain two different families of the extended RMF model corresponding to different non-linear cross-coupling term in the isovector part of the effective Lagrangian density. The lowest order contributions for the $\\delta$ mesons are also included. The different models within the same family are so obtained that they yield wide variation in the value of neutron-skin thickness in the $^{208}$Pb nucleus. These models are employed to compute the neutron star properties such as, core-crust transition density, radius and red shift at canonical mass ($1.4M_{\\odot}$), tidal polarizability parameter, and threshold mass required for the enhanced cooling through direct Urca process. Most of the neutron star properties considered are signi...

  13. Search for deeply bound pionic states in {sup 208}Pb via radiative atomic capture of negative pions

    Energy Technology Data Exchange (ETDEWEB)

    Raywood, K.J.; Lange, J.B.; Jones, G.; Pavan, M. [Department of Physics, University of British Columbia, Vancouver, British Columbia, V6T 1Z1 (CANADA); Sevior, M.E. [School of Physics, University of Melbourne, Parkville Victoria, 3052 (Australia); Hutcheon, D.A.; Olin, A.; Ottewell, D.; Yen, S. [TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia, V6T 2A3 (CANADA); Lee, S.J.; Sim, K.S. [Department of Physics, Korea University, Seoul 136-701 (Korea); Altman, A. [Direx Medical Services, P.O. Box 4190, Petah-Tikva, 41920 (Israel); Friedman, E. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel); Trudel, A. [Simon Fraser University, Burnaby, British Columbia, V5A 1S6 (CANADA)

    1997-05-01

    A search for narrow, deeply bound pionic atom states via atomic radiative capture of negative pions in a target of {sup 208}Pb was carried out for pion kinetic energies of 20 and 25 MeV. Although no clear signature of any such gamma ray emission could be observed in the data, fits of the gamma ray spectra between the energies of 12 and 42 MeV involving a quadratic background together with a pair of peaks (1s, 2p) whose relative intensity was taken from theory yielded an overall strength for the peaks which are consistent (to a 67{percent} confidence level) with radiative capture whose integrated cross section is 20.0 {plus_minus} 10.0 {mu}b/sr at 90{degree} for 20 MeV incident pions. A lower probability (40{percent} confidence level) result was obtained when the fit was carried out without the peaks included, just the continuum background. {copyright} {ital 1997} {ital The American Physical Society}

  14. Proliferative effect of ammodytin L from the venom of Vipera ammodytes on 208F rat fibroblasts in culture.

    Science.gov (United States)

    Rufini, S; Cesaroni, M P; Balestro, N; Luly, P

    1996-12-01

    Ammodytin L, purified from the venom of Vipera ammodytes, triggers a rapid and dramatic lytic process in myotubes in vitro, as well as in differentiated muscle cells in vivo, through a mechanism that is not well understood. Despite its great sequence similarity to phospholipase A2, it is devoid of any enzyme activity. Data on artificial membranes demonstrating a direct interaction between this toxin and the hydrophobic core of the lipid bilayer suggest that the toxin also acts on the lipid microenvironment in cell membranes. Recent experiments on living cells do not confirm this hypothesis, and a more intricate mechanism is proposed. In vitro, ammodytin L has necrotic effects only in well-differentiated myogenic cells, whereas other cell types such as platelets, red blood cells and lymphocytes show neither morphological nor functional alterations. In this work we demonstrate that rat 208F fibroblasts in culture after ammodytin L challenge increase [3H]thymidine incorporation, indicating that this toxin has a myogenic effect. Moreover, ammodytin L increases intracellular Ca2+ by acting on intracellular stores probably by activating a phosphatidylinositol-specific phospholipase C. Preincubation of the cells with ammodytin L did not prevent the massive Ca2+ release evoked by bradykinin, a phenomenon observed when fibroblasts were incubated with both thapsigargin and ionomycin. Heparin, an agent that inhibits the necrotic effect of the myotoxin in myotubes, also reduces the effect of ammodytin L on DNA synthesis. Heparin inhibits only the late sustained increase in intracellular Ca2+ induced by the toxin.

  15. miR-208a在大鼠心肌缺血再灌注损伤及缺血后处理中的表达及其作用%Expression and mechanism of miR-208a in rat myocardial ischemia reperfusion injury and ischemic postconditioning

    Institute of Scientific and Technical Information of China (English)

    陈耽; 李骊华

    2015-01-01

    目的:探讨miR-208a及α-肌球蛋白重链(α-myosin heavy chain,a-MHC)、β-肌球蛋白重链(β-myosin heavy chain,β-MHC)在大鼠心肌缺血再灌注损伤(ischemia reperfusion injury,IR)及缺血后处理(ischemic postconditioning,IPO)中的表达变化及其作用.方法:取SD大鼠,使用改良垫扎球囊法建立IR模型,随机分为3组(每组6只),Sham组、IR组、IPO组.检测各组血流动力学指标;real-time PCR检测miR-208a、α-MHC、β-MHC基因表达;Western blot检测α-MHC、β-MHC蛋白含量.结果:与IR组相比,IPO能明显降低左室舒张末期容积(left ventricular end diastolic volume,LVEDV)和左室收缩末期容积(left yen-tricular end systolic volume,LVESV),增加左室射血分数(left ventricular ejection fraction,LVEF)和左室短轴缩短率(left ventricular fraction shorting,LVFS),改善心功能.miR-208a表达水平在IR组明显增加,IPO组明显降低.β-MHC表达在IR组明显上调,IPO组明显下调,且基因和蛋白表达水平一致.α-MHC基因和蛋白表达水平在3组无明显差异.结论:miR-208a和β-MHC在缺血再灌注组明显增加,缺血后处理能使miR-208a和β-MHC表达下降,并在一定程度上改善心功能.%Objective:To observe the expression changes of miR-208a in rat acute myocardium ischemia reperfusion injury (IR) and ischemic postconditioning,to investigate the probable mechanism of miR-208a in the protection of ischemic postconditioning.Methods:Sprague-Dawley rats were randomly assigned into 3 groups:sham operation group,ischemia reperfusion group and ischemic postconditioning group.The hemodynamic values and cardiac function were analyzed by echocardiography.The gene expression of miR-208a,α-MHC,and β-MHC was detected by real-time PCR.Western blot was used to assess the protein expression of α-MHC and β-MHC in the area at risk at the end of reperfusion.Results:Postconditioning in vivo rats reduced the hemodynamic values of left ventricular end diastolic volume (LVEDV

  16. The i11/2 f5/2 and i11/2 p3/2 neutron particle-hole multiplets in 208Pb

    CERN Document Server

    Heusler, A; Graw, G; Hertenberger, R; Jolie, J; Krücken, R; Pietralla, N; Riess, F; Von Brentano, P; Wirth, H F

    2006-01-01

    Inelastic proton scattering via isobaric analog resonances allows to derive rather complete information about neutron particle-hole states. We applied this method to the doubly-magic nucleus 208Pb by measuring angular distributions of 208Pb(p, p') on top of the isobaric analog resonances in 209Bi with the Q3D magnetic spectrograph at M\\"unchen. We identify the six states of the i11/2 f5/2 multiplet and the four states of the i11/2 p3/2 multiplet in the energy range 4.6 MeV < Ex < 5.3 MeV. Firm spin assignments for the ten states are given, some of them new. Additional measurements of the reaction 207Pb(d, p) confirm the fragmented i11/2 p1/2 multiplet.

  17. Performance of transonic fan stage with weight flow per unit annulus area of 208 kilograms per second per square meter (42.6 (lb/sec)/sq ft)

    Science.gov (United States)

    Urasek, D. C.; Kovich, G.; Moore, R. D.

    1973-01-01

    Performance was obtained for a 50-cm-diameter compressor designed for a high weight flow per unit annulus area of 208 (kg/sec)/sq m. Peak efficiency values of 0.83 and 0.79 were obtained for the rotor and stage, respectively. The stall margin for the stage was 23 percent, based on equivalent weight flow and total-pressure ratio at peak efficiency and stall.

  18. Study of collisions of the radioactive {sup 24}Ne beam at 7.9 MeV/u on {sup 208}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Benzoni, G. [INFN sezione di Milano, Milano (Italy); Azaiez, F.; Franchoo, S.; Verney, D. [IPN, IN2P3-CNRS, Orsay Cedex (France); Stefan, G.I. [IPN, IN2P3-CNRS, Orsay Cedex (France); GANIL, B. P. 55027, Caen Cedex 5 (France); Battacharyya, S.; France, G. de; Grevy, S.; Ibrahim, F.; Mukherjee, G. [GANIL, B. P. 55027, Caen Cedex 5 (France); Borcea, R. [Horia Hulubei National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Bracco, A.; Leoni, S.; Montanari, D. [INFN sezione di Milano, Milano (Italy); Universita degli Studi di Milano, Milano (Italy); Corradi, L.; Fioretto, E. [INFN-Laboratori Nazionali di Legnaro (Italy); Curien, D. [IN2P3-CNRS et Universite Louis Pasteur, IPHC, Strasbourg Cedex 2 (France); Dombradi, Zs.; Sohler, D. [Institute of Nuclear Research of the Hungarian Academy of Sciences, P.O. Box 51, Debrecen (Hungary); Pollarolo, G. [Universita di Torino (Italy); INFN sezione di Torino, Dipartimento di fisica Teorica, Torino (Italy); Redon, N. [IN2P3-CNRS et Universite Claude Bernard, IPNL, Villeurbanne Cedex (France); Regan, P.H. [University of Surrey, Department of Physics, Guildford (United Kingdom); Schmitt, C. [GANIL, B. P. 55027, Caen Cedex 5 (France); IN2P3-CNRS et Universite Claude Bernard, IPNL, Villeurbanne Cedex (France); Sletten, G. [University of Copenhagen, Niels Bohr Institute, Copenhagen (Denmark); Stanoiu, M. [IPN, IN2P3-CNRS, Orsay Cedex (France); Horia Hulubei National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Szilner, S. [Ruder Boskovic Institute, Zagreb (Croatia)

    2010-09-15

    Cross-sections of the main reaction channels for the collision {sup 24}Ne+{sup 208}Pb at 7.9MeV/u were studied using the radioactive ion beam delivered by the SPIRAL facility and the VAMOS-EXOGAM experimental set-up. Angular distributions for the elastic and inelastic channels were extracted, together with distributions for the +1n and -1p channels. A comprehensive description of the present data is made within the GRAZING model approach. (orig.)

  19. Relevance of single-particle and collective excitations in zirconium isotopes populated by neutron transfer reactions in the {sup 90}Zr+{sup 208}Pb system

    Energy Technology Data Exchange (ETDEWEB)

    Pajtler, M. Varga, E-mail: maja.varga@fizika.unios.hr [Department of Physics, University of Osijek, Trg Ljudevita Gaja 6, 31000 Osijek (Croatia); Szilner, S.; Malenica, D. Jelavić; Mijatović, T.; Soić, N. [Ruer Bošković Institute, HR-10001, Zagreb (Croatia); Corradi, L.; Angelis, G. de; Fioretto, E.; Montanari, D.; Stefanini, A. M.; Valiente-Dobón, J. J. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, I-35020 Legnaro (Italy); Gadea, A. [IFIC, CSIC-Universidad de Valencia, E-46071 Valencia (Spain); Haas, F. [Institut Pluridisciplinaire Hubert Curien, CNRS-IN2P3 and Université de Strasbourg, F-67037 Strasbourg (France); Lunardi, S.; Mengoni, D.; Montagnoli, G.; Recchia, F.; Scarlassara, F. [Dipartimento di Fisica, Universitá di Padova, and Istituto Nazionale di Fisica Nucleare, I-35131 Padova (Italy); Märginean, N. [Horia Hulubei National Institute of Physics and Nuclear Engineering, RO-077125 Bucharest-Magurele (Romania); Pollarolo, G. [Dipartimento di Fisica Teorica, Universitá di Torino,and Istituto Nazionale di Fisica Nucleare, I-10125 Torino (Italy); and others

    2015-10-15

    Multineutron transfer reaction {sup 90}Zr+{sup 208}Pb has been studied at the energy close to the Coulomb barrier energy by using the PRISMA + CLARA set-up. In this fragment-γ coincidence measurement, the selective properties of the reaction mechanism in the population of the specific states have been discussed. Based on the observed γ transitions of neutron transfer channels, namely {sup 89–94}Zr isotopes, their level schemes have been constructed and updated.

  20. The power of two: Assessing the impact of a second measurement of the weak-charge form factor of 208Pb

    CERN Document Server

    Piekarewicz, J; Giuliani, P; Chicken, E

    2016-01-01

    [Background] Besides its intrinsic value as a fundamental nuclear-structure observable, the weak-charge density of 208Pb - a quantity that is closely related to its neutron distribution - is of fundamental importance in constraining the equation of state of neutron-rich matter. [Purpose] To assess the impact that a second electroweak measurement of the weak-charge form factor of 208Pb may have on the determination of its overall weak-charge density. [Methods] Using the two putative experimental values of the form factor, together with a simple implementation of Bayes' theorem, we calibrate a theoretically sound - yet surprisingly little known - symmetrized Fermi function, that is characterized by a density and form factor that are both known exactly in closed form. [Results] Using the charge form factor of 208Pb as a proxy for its weak-charge form factor, we demonstrate that using only two experimental points to calibrate the symmetrized Fermi function is sufficient to accurately reproduce the experimental ch...

  1. Complete genome sequence of Acinetobacter baumannii XH386 (ST208, a multi-drug resistant bacteria isolated from pediatric hospital in China

    Directory of Open Access Journals (Sweden)

    Youhong Fang

    2016-03-01

    Full Text Available Acinetobacter baumannii is an important bacterium that emerged as a significant nosocomial pathogen worldwide. The rise of A. baumannii was due to its multi-drug resistance (MDR, while it was difficult to treat multi-drug resistant A. baumannii with antibiotics, especially in pediatric patients for the therapeutic options with antibiotics were quite limited in pediatric patients. A. baumannii ST208 was identified as predominant sequence type of carbapenem resistant A. baumannii in the United States and China. As we knew, there was no complete genome sequence reproted for A. baumannii ST208, although several whole genome shotgun sequences had been reported. Here, we sequenced the 4087-kilobase (kb chromosome and 112-kb plasmid of A. baumannii XH386 (ST208, which was isolated from a pediatric hospital in China. The genome of A. baumannii XH386 contained 3968 protein-coding genes and 94 RNA-only encoding genes. Genomic analysis and Minimum inhibitory concentration assay showed that A. baumannii XH386 was multi-drug resistant strain, which showed resistance to most of antibiotics, except for tigecycline. The data may be accessed via the GenBank accession number CP010779 and CP010780.

  2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Ai ds (CEF); Scientific Opinion on Flavouring Group Evaluation 208 (FGE.208): Consideration of genotoxicity data on representatives for 10 alicyclic aldehydes with the α , β - unsaturation in ring / side - chain

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Lund, Pia

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of one flavouring substance from subgroup 2.2 of FGE.19 in the Flavouring Group Evaluation 208. The Flavour Industry has provided a...

  3. Comment: 208 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available main CDC(Centers for Disease Control and Prevention)のimage libraryから(Public Domain) http://phil.cdc.gov/phil/home.asp bando 2010/02/15 14:45:35 2010/02/15 14:48:55 ...

  4. Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients.

    Science.gov (United States)

    Betancor, Gilberto; Nevot, María; Mendieta, Jesús; Gómez-Puertas, Paulino; Martínez, Miguel A; Menéndez-Arias, Luis

    2014-06-01

    Thymidine analogue resistance mutations (TAMs) in HIV-1 reverse transcriptase (RT) associate in two clusters: (i) TAM1 (M41L, L210W and T215Y) and TAM2 (D67N, K70R, K219E/Q, and sometimes T215F). The amino acid substitution H208Y shows increased prevalence in patients treated with nucleoside analogues and is frequently associated with TAM1 mutations. We studied the molecular mechanism favoring the selection of H208Y in the presence of zidovudine, tenofovir and other nucleoside RT inhibitors (NRTIs). NRTI susceptibility was not affected by the addition of H208Y in phenotypic assays carried out in MT-4 cells using recombinant HIV-1 containing wild-type (subtype B, BH10), H208Y, M41L/L210W/T215Y or M41L/H208Y/L210W/T215Y RTs. However, enzymatic studies carried out with purified RTs revealed that in the presence of M41L/L210W/T215Y, H208Y increases the RT's ability to unblock and extend primers terminated with zidovudine, tenofovir and in a lesser extent, stavudine. These effects were observed with DNA/DNA complexes (but not with RNA/DNA) and resulted from the higher ATP-dependent excision activity of the M41L/H208Y/L210W/T215Y RT compared with the M41L/L210W/T215Y mutant. The increased rescue efficiency of the M41L/H208Y/L210W/T215Y RT was observed in the presence of ATP but not with GTP or ITP. Molecular dynamics studies predict an alteration of the stacking interactions between Tyr(215) and the adenine ring of ATP due to long-distance effects caused by tighter packaging of Tyr(208) and Trp(212). These studies provide a mechanistic explanation for the association of TAM-1 and H208Y mutations in viral isolates from patients treated with NRTIs. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. {alpha}-particle production in the scattering of {sup 6}He by {sup 208}Pb at energies around the Coulomb barrier

    Energy Technology Data Exchange (ETDEWEB)

    Escrig, D. [Instituto de Estructura de la Materia, CSIC, E-28006 Madrid (Spain); Sanchez-Benitez, A.M. [Departamento de Fisica Aplicada, Universidad de Huelva, E-21071 Huelva (Spain); Institut de Physique Nucleaire and Centre de Recherches du Cyclotron, Universite catholique de Louvain, B-1348 Louvain-la-Neuve (Belgium); Moro, A.M. [Departamento de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, Apdo. 1065, E-41080 Sevilla (Spain)]. E-mail: moro@us.es (and others)

    2007-08-01

    New experimental data from the scattering of {sup 6}He + {sup 208}Pb at energies around and below the Coulomb barrier are presented. The yield of breakup products coming from projectile fragmentation is dominated by a strong group of {alpha} particles. The energy and angular distribution of this group have been analyzed and compared with theoretical calculations. This analysis indicates that the {alpha} particles emitted at backward angles in this reaction are mainly due to two-neutron transfer to weakly bound states of the final nucleus.

  6. Selective properties of neutron transfer reactions in the {sup 90}Zr + {sup 208}Pb system for the population of excited states in zirconium isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Varga Pajtler, M., E-mail: mvarga@fizika.unios.hr [Department of Physics, University of Osijek, HR-31000 Osijek (Croatia); Szilner, S. [Rudjer Bošković Institute, HR-10001 Zagreb (Croatia); Corradi, L.; Angelis, G. de; Fioretto, E. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, I-35020 Legnaro (Italy); Gadea, A. [IFIC, CSIC-Universidad de Valencia, E-46071 Valencia (Spain); Haas, F. [Institut Pluridisciplinaire Hubert Curien, CNRS-IN2P3 and Université de Strasbourg, F-67037 Strasbourg (France); Lunardi, S. [Dipartimento di Fisica, Universitá di Padova, and Istituto Nazionale di Fisica Nucleare, I-35131 Padova (Italy); Jelavić Malenica, D. [Rudjer Bošković Institute, HR-10001 Zagreb (Croatia); Mărginean, N. [Horia Hulubei National Institute of Physics and Nuclear Engineering, RO-077125 Bucharest-Magurele (Romania); Mengoni, D. [Dipartimento di Fisica, Universitá di Padova, and Istituto Nazionale di Fisica Nucleare, I-35131 Padova (Italy); Mijatović, T. [Rudjer Bošković Institute, HR-10001 Zagreb (Croatia); Montagnoli, G. [Dipartimento di Fisica, Universitá di Padova, and Istituto Nazionale di Fisica Nucleare, I-35131 Padova (Italy); Montanari, D. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, I-35020 Legnaro (Italy); Pollarolo, G. [Dipartimento di Fisica Teorica, Universitá di Torino, and Istituto Nazionale di Fisica Nucleare, I-10125 Torino (Italy); and others

    2015-09-15

    Nuclei produced via multineutron transfer channels have been studied in {sup 90}Zr + {sup 208}Pb close to the Coulomb barrier energy in a fragment-γ coincident measurement employing the PRISMA magnetic spectrometer coupled to the CLARA γ-array. The selective properties of the reaction mechanism have been discussed in terms of states and their strength excited in the neutron transfer channels leading to {sup 89–94}Zr isotopes. A strong population of yrast states, with energies up to ∼7.5 MeV has been observed.

  7. Selective properties of neutron transfer reactions in the 90Zr + 208Pb system for the population of excited states in zirconium isotopes

    Science.gov (United States)

    Varga Pajtler, M.; Szilner, S.; Corradi, L.; de Angelis, G.; Fioretto, E.; Gadea, A.; Haas, F.; Lunardi, S.; Jelavić Malenica, D.; Mărginean, N.; Mengoni, D.; Mijatović, T.; Montagnoli, G.; Montanari, D.; Pollarolo, G.; Recchia, F.; Salsac, M.-D.; Scarlassara, F.; Soić, N.; Stefanini, A. M.; Ur, C. A.; Valiente-Dobón, J. J.

    2015-09-01

    Nuclei produced via multineutron transfer channels have been studied in 90Zr + 208Pb close to the Coulomb barrier energy in a fragment-γ coincident measurement employing the PRISMA magnetic spectrometer coupled to the CLARA γ-array. The selective properties of the reaction mechanism have been discussed in terms of states and their strength excited in the neutron transfer channels leading to 89-94Zr isotopes. A strong population of yrast states, with energies up to ∼7.5 MeV has been observed.

  8. In vitro screening of reversible and time-dependent inhibition on CYP3A by TM208 and TM209 in rat liver microsomes

    OpenAIRE

    Miaoran Ning; Liang Li; Jian Li; Zaiquan Li; Runtao Li; Tianyan Zhou; Wei Lu

    2012-01-01

    TM208 and TM209, dithiocarbamate derivatives with potential anti-cancer effects, were evaluated in reversible and time-dependent cytochrome P450 (CYP) 3A inhibition assays in rat liver microsomes using testosterone as probe substrate. Both compounds were found to be weak reversible inhibitors and moderate mechanism-based inhibitors of rat CYP3A. For reversible inhibition on rat CYP3A, the Ki values of competitive inhibition model were 12.10±1.75 and 13.94±1.31 μM, respectively. For time-depen...

  9. Testing the Mutually Enhanced Magicity Effect in Nuclear Incompressibility via the Giant Monopole Resonance in the $^{204,206,208}$Pb Isotopes

    CERN Document Server

    Patel, D; Fujiwara, M; Adachi, T; Akimune, H; Berg, G P A; Harakeh, M N; Itoh, M; Iwamoto, C; Long, A; Matta, J T; Murakami, T; Okamoto, A; Sault, K; Talwar, R; Uchida, M; Yosoi, M

    2013-01-01

    Using inelastic $\\alpha$-scattering at extremely forward angles, including $0^\\circ$, the strength distributions of the isoscalar giant monopole resonance (ISGMR) have been measured in the $^{204,206,208}$Pb isotopes in order to examine the proposed mutually enhanced magicity (MEM) effect on the nuclear incompressibility. The MEM effect had been suggested as a likely explanation of the "softness" of nuclear incompressibility observed in the ISGMR measurements in the Sn and Cd isotopes. Our experimental results rule out any manifestation of the MEM effect in nuclear incompressibility and leave the question of the softness of the open-shell nuclei unresolved still.

  10. Doorway-state analysis of the fine structure in the giant quadrupole resonance in 208Pb observed in inelastic electron scatteredrefid="FN1">†

    Science.gov (United States)

    Winchenbach, J.; Pingel, K.; Holzwarth, G.; Kühner, G.; Richter, A.

    1983-11-01

    The fine structure observed in high resolution inelastic electron scattering data obtained at DALINAC for 208Pb in the excitation energy range of the giant quadrupole resonance (GQR) has been analysed under the assumption that the measured strongly fragmented E2 strength distribution is due to the coupling of one or two doorway states to a large number of more complicated states. The coupling matrix elements derived from the analysis allow the determination of the escape and spreading widths Γ ↑ and Γ ↓, the excitation energies Ed, the energy shifts ΔEd, and their energy dependence, for the underlying doorways.

  11. Dominant winter-time mesospheric wave signatures over a low latitude station, Hawaii (20.8°N): An investigation

    Indian Academy of Sciences (India)

    A Taori; M Taylor

    2010-06-01

    We utilize mesospheric O2 airglow emission intensity and temperature data collected during January–February 2003 on 17 consecutive nights from Maui, Hawaii (20.8°N, 156.2°W) to study the dominant and long period wave features at mesospheric altitudes. Apart from large day-to-day variability, it is found that nocturnal data for the period under consideration was dominated by a terdiurnal tide-like wave. Together, a quasi 5-day wave is also noticed with significant amplitude.

  12. Completion Report for Wells ER-20-8 and ER-20-8#2 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Management

    2011-02-28

    Wells ER-20-8 and ER-20-8#2 were drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The holes were drilled in July and August 2009, as part of the Pahute Mesa Phase II drilling program. The primary purpose of these wells was to provide detailed hydrogeologic information in the Tertiary volcanic section that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic framework model. They may also be used as long-term monitoring wells.

  13. Searches for supersymmetric particles in $e^{+} e^{-}$ collisions up to 208 GeV and interpretation of the results within the MSSM

    CERN Document Server

    Abdallah, J.; Adam, W.; Adzic, P.; Albrecht, T.; Alderweireld, T.; Alemany-Fernandez, R.; Allmendinger, T.; Allport, P.P.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.D.; Arnoud, Y.; Ask, S.; Asman, B.; Augustin, J.E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barbier, R.; Bardin, D.; Barker, G.J.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.H.; Begalli, M.; Behrmann, A.; Ben-Haim, E.; Benekos, N.; Benvenuti, A.; Berat, C.; Berggren, M.; Berntzon, L.; Bertrand, D.; Besancon, M.; Besson, N.; Bloch, D.; Blom, M.; Bluj, M.; Bonesini, M.; Boonekamp, M.; Booth, P.S.L.; Borisov, G.; Botner, O.; Bouquet, B.; Bowcock, T.J.V.; Boyko, I.; Bracko, M.; Brenner, R.; Brodet, E.; Bruckman, P.; Brunet, J.M.; Bugge, L.; Buschmann, P.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Castro, Nuno Filipe; Cavallo, F.; Chapkin, M.; Charpentier, P.; Checchia, P.; Chierici, R.; Chliapnikov, P.; Chudoba, J.; Chung, S.U.; Cieslik, K.; Collins, P.; Contri, R.; Cosme, G.; Cossutti, F.; Costa, M.J.; Crawley, B.; Crennell, D.; Cuevas, J.; D'Hondt, J.; Dalmau, J.; da Silva, T.; Da Silva, W.; Della Ricca, G.; De Angelis, A.; De Boer, W.; De Clercq, C.; De Lotto, B.; De Maria, N.; De Min, A.; de Paula, L.; Di Ciaccio, L.; Di Simone, A.; Doroba, K.; Drees, J.; Dris, M.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Espirito Santo, M.C.; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferro, F.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fulda-Quenzer, F.; Fuster, J.; Gandelman, M.; Garcia, C.; Gavillet, P.; Gazis, Evangelos; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hallgren, A.; Hamacher, K.; Hamilton, K.; Hansen, J.; Haug, S.; Hauler, F.; Hedberg, V.; Hennecke, M.; Herr, H.; Hoffman, J.; Holmgren, S.O.; Holt, P.J.; Houlden, M.A.; Hultqvist, K.; Jackson, John Neil; Jarlskog, G.; Jarry, P.; Jeans, D.; Johansson, Erik Karl; Johansson, P.D.; Jonsson, P.; Joram, C.; Jungermann, L.; Kapusta, Frederic; Katsanevas, S.; Katsoufis, E.; Kernel, G.; Kersevan, B.P.; Kiiskinen, A.; King, B.T.; Kjaer, N.J.; Kluit, P.; Kokkinias, P.; Kourkoumelis, C.; Kouznetsov, O.; Krumstein, Z.; Kucharczyk, M.; Lamsa, J.; Leder, G.; Ledroit, Fabienne; Leinonen, L.; Leitner, R.; Lemonne, J.; Lepeltier, V.; Lesiak, T.; Liebig, W.; Liko, D.; Lipniacka, A.; Lopes, J.H.; Lopez, J.M.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Malek, A.; Maltezos, S.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Mazzucato, F.; Mazzucato, M.; McNulty, R.; Meroni, C.; Meyer, W.T.; Migliore, E.; Mitaroff, W.; Mjoernmark, U.; Moa, T.; Moch, M.; Monig, Klaus; Monge, R.; Montenegro, J.; Moraes, D.; Moreno, S.; Morettini, P.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.; Murray, W.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.; Nawrocki, K.; Nicolaidou, R.; Nikolenko, M.; Oblakowska-Mucha, A.; Obraztsov, V.; Olshevski, A.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Palacios, J.P.; Palka, H.; Papadopoulou, T.D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Peralta, L.; Perepelitsa, V.; Perrotta, A.; Petrolini, A.; Piedra, J.; Pieri, L.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M.E.; Polok, G.; Poropat, P.; Pozdniakov, V.; Pukhaeva, N.; Pullia, A.; Rames, J.; Ramler, L.; Read, Alexander L.; Rebecchi, P.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.; Richard, F.; Ridky, J.; Rivero, M.; Rodriguez, D.; Romero, A.; Ronchese, P.; Rosenberg, E.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ryabtchikov, D.; Sadovsky, A.; Salmi, L.; Salt, J.; Savoy-Navarro, A.; Schwickerath, U.; Segar, A.; Sekulin, R.; Siebel, M.; Sisakian, A.; Smadja, G.; Smirnova, O.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Stanitzki, M.; Stocchi, A.; Strauss, J.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Szumlak, T.; Tabarelli, T.; Taffard, A.C.; Tegenfeldt, F.; Timmermans, Jan; Tkatchev, L.; Tobin, M.; Todorovova, S.; Tome, B.; Tonazzo, A.; Tortosa, P.; Travnicek, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.L.; Tyapkin, I.A.; Tyapkin, P.; Tzamarias, S.; Uvarov, V.; Valenti, G.; Van Dam, Piet; Van Eldik, J.; Van Lysebetten, A.; van Remortel, N.; Van Vulpen, I.; Vegni, G.; Veloso, F.; Venus, W.; Verbeure, F.; Verdier, P.; Verzi, V.; Vilanova, D.; Vitale, L.; Vrba, V.; Wahlen, H.; Washbrook, A.J.; Weiser, C.; Wicke, D.; Wickens, J.; Wilkinson, G.; Winter, M.; Witek, M.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zhuravlov, V.; Zimine, N.I.; Zintchenko, A.; Zupan, M.

    2004-01-01

    DELPHI data collected at centre-of-mass energies up to 208 GeV have been analysed to search for charginos, neutralinos and sfermions in the framework of the Minimal Supersymmetric Standard Model (MSSM) with R-parity conservation. No evidence for a signal was found in any of the channels. The results of each search were used to derive limits on production cross-sections and particle masses. In addition, the combined result of all searches excludes regions in the parameter space of the constrained MSSM, leading to limits on the mass of the Lightest Supersymmetric Particle and other supersymmetric particles.

  14. Long range absorption in the scattering of {sup 6}He on {sup 208}Pb and {sup 197}Au at 27 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Kakuee, O.R. [Van De Graaf Laboratory, Nuclear Research Centre, AEOI, P.O. Box 14155-1339, Tehran (Iran, Islamic Republic of)]|[Departamento de Fisica Atomica, Molecular y Nuclear, Apartado 1065, Universidad de Sevilla, E-41080 Sevilla (Spain); Alvarez, M.A.G. [Departamento de Fisica Atomica, Molecular y Nuclear, Apartado 1065, Universidad de Sevilla, E-41080 Sevilla (Spain); Andres, M.V. [Departamento de Fisica Atomica, Molecular y Nuclear, Apartado 1065, Universidad de Sevilla, E-41080 Sevilla (Spain); Cherubini, S. [Department de Physique Nucleaire, Universite Catholique, Louvain-la-Neuve (Belgium)]|[Institut fuer Experimentalphysik III, Ruhr-Universitaet Bochum (Germany); Davinson, T.; Di Pietro, A.; Laird, A.M.; Shotter, A.C.; Smith, W.B.; Woods, P.J. [Department of Physics and Astronomy, Edinburgh University, EH9 3JZ (United Kingdom); Galster, W. [Department de Physique Nucleaire, Universite Catholique, Louvain-la-Neuve (Belgium); Gomez-Camacho, J. [Departamento de Fisica Atomica, Molecular y Nuclear, Apartado 1065, Universidad de Sevilla, E-41080 Sevilla (Spain)]. E-mail: gomez@us.es; Lamehi-Rachti, M. [Van De Graaf Laboratory, Nuclear Research Centre, AEOI, P.O. Box 14155-1339, Tehran (Iran, Islamic Republic of); Martel, I. [Departamento de Fisica Aplicada, Universidad de Huelva, E-21819 Huelva (Spain); Moro, A.M. [Departamento de Fisica Atomica, Molecular y Nuclear, Apartado 1065, Universidad de Sevilla, E-41080 Sevilla (Spain); Rahighi, J. [Van De Graaf Laboratory, Nuclear Research Centre, AEOI, P.O. Box 14155-1339, Tehran (Iran, Islamic Republic of)]|[Department of Physics and Astronomy, Edinburgh University, EH9 3JZ (United Kingdom); Sanchez-Benitez, A.M. [Departamento de Fisica Aplicada, Universidad de Huelva, E-21819 Huelva (Spain); Vervier, J. [Department de Physique Nucleaire, Universite Catholique, Louvain-la-Neuve (Belgium)

    2006-02-06

    Quasi-elastic scattering of {sup 6}He at E{sub lab}=27 MeV from {sup 197}Au has been measured in the angular range of 6{sup o}-72{sup o} in the laboratory system employing LEDA and LAMP detection systems. These data, along previously analysed data of {sup 6}He+{sup 208}Pb at the same energy, are analysed using optical model calculations. The role of Coulomb dipole polarizability has been investigated. Large imaginary diffuseness parameters are required to fit the data. This result is an evidence for long range absorption mechanisms in {sup 6}He induced reactions.

  15. Pion-nucleus elastic scattering on $^{12}C$, $^{40}Ca$, $^{90}Zr$, and $^{208}Pb$ at 400 and 500 MeV

    CERN Document Server

    Kahrimanis, G; Chen, C M; Clark, B C; Dhuga, K S; Ernst, D J; Faucett, J A; Fortune, H T; Hama, S; Hussein, A; Jiang, M F; Johnson, K W; Kerr, L K; Mathews, S; McGill, J A; Moore, C F; Mordechai, S; Morris, C L; O'Donnell, J; Snell, M; Rawool-Sullivan, M; Ray, L; Whitley, C; Williams, A L; Kahrimanis, George; Burleson, George; Dhuga, Kalvir; Hussein, Ahmed; Mathews, Scott; Gill, John Mc; Mordechai, Shaul; Morris, Christopher L.; Donnell, John O'; Snell, Mike; Rawool-Sullivan, Mohini; Whitley, Charles; Williams, Allen L.

    1997-01-01

    Pion-nucleus elastic scattering at energies above the Delta(1232) resonance is studied using both pi+ and pi- beams on 12C, 40Ca, 90Zr, and 208Pb. The present data provide an opportunity to study the interaction of pions with nuclei at energies where second-order corrections to impulse approximation calculations should be small. The results are compared with other data sets at similar energies, and with four different first-order impulse approximation calculations. Significant disagreement exists between the calculations and the data from this experiment.

  16. Search for supersymmetric particles assuming R-parity non-conservation in $e^+e^-$ collisions at $\\sqrt{s}$ = 192 to 208 GeV

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alderweireld, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barbier, R; Bardin, Dimitri Yuri; Barker, G J; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Berntzon, L; Bertrand, D; Besançon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Brückman, P; Brunet, J M; Bugge, L; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F R; Chapkin, M M; Charpentier, P; Checchia, P; Chierici, R; Shlyapnikov, P; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M J; Crennell, D J; Cuevas-Maestro, J; D'Hondt, J; Dalmau, J; Da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L S; Di Ciaccio, L; Di Simone, A; Doroba, K; Drees, J; Dris, M; Eigen, G; Ekelöf, T J C; Ellert, M; Elsing, M; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Feindt, M; Fernández, J; Ferrer, A; Ferro, F; Flagmeyer, U; Föth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J A; Gandelman, M; García, C; Gavillet, P; Gazis, E N; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Herr, H; Hoffman, J; Holmgren, S O; Holt, P J; Houlden, M A; Hultqvist, K; Jackson, J N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E K; Johansson, P D; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E C; Kernel, G; Kersevan, B P; Kerzel, U; Kiiskinen, A P; King, B T; Kjaer, N J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kuznetsov, O; Krumshtein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; López, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Migliore, E; Mitaroff, W A; Mjörnmark, U; Moa, T; Moch, M; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Müller, U; Münich, K; Mulders, M; Mundim, L; Murray, W; Muryn, B; Myatt, G; Myklebust, T; Nassiakou, M; Navarria, Francesco Luigi; Nawrocki, K; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, R; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V F; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Pozdnyakov, V; Pukhaeva, N; Pullia, Antonio; Rames, J; Read, A; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P B; Richard, F; Rídky, J; Rivero, M; Rodríguez, D; Romero, A; Ronchese, P; Roudeau, P; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovskii, A; Salmi, L; Salt, J; Sander, C; Savoy-Navarro, A; Schwickerath, U; Segar, A; Sekulin, R L; Siebel, M; Sissakian, A N; Smadja, G; Smirnova, O G; Sokolov, A; Sopczak, A; Sosnowski, R; Spassoff, Tz; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Timmermans, J; Tkatchev, L G; Tobin, M; Todorovova, S; Tomé, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M L; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; van Dam, P; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I; Vegni, G; Veloso, F; Venus, W A; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O P; Zalewska-Bak, A; Zalewski, P; Zavrtanik, D; Zhuravlov, V; Zimin, N I; Zintchenko, A; Zupan, M

    2004-01-01

    Searches for pair-production of supersymmetric particles under the assumption of non-conservation of R-parity with a dominant LLEbar or UbarDbarDbar term have been performed using the data collected by the DELPHI experiment at LEP in e+e- collisions at centre-of-mass energies from 192 up to 208 GeV. No excess of data above Standard Model expectations was observed. The results were used to constrain the MSSM parameter space and to derive limits on the masses of supersymmetric particles.

  17. 冠心病患者血清同型半胱氨酸、miR-1、miR-126和 miR-208的相关性分析%Correlation analysis of Hcy,miR-1,miR-126 and miR-208 in coronary heart disease patients

    Institute of Scientific and Technical Information of China (English)

    金洁; 王俊; 王磊; 蔡晓敏; 王立军; 宫剑滨

    2014-01-01

    Objective To study the correlation between miRNA (miR-1,miR-126,miR-208) and homocysteine (Hcy) con-bining on the severity of stenosis of coronary artery .Methods One hundred and two patients undergoing quantitative coronary angiogra -phy were involved in this study .Patients were categorized into control group and coronary artery disease ( CAD) group.The concentra-tion of Hcy and miRNA (miR-1,miR-126,miR-208) were measured.The severity scale of coronary artery stenosis was quantitatively assessed according to coronary angiography by Gensini score .The correlation analysis and linear regression were used to show the asso-ciation of Hcy,miRNA (miR-1,miR-126 and miR-208) and Gensini score.Results The concentration of Hcy and miRNA (miR-1, miR-126 and miR-208) were higher in CAD group than those in control group .In the correlation analysis ,Gensini score was positively associated with Hcy,miR-1 and miR-126 (r=0.575,0.649,and 0.499,P<0.01) and the positive correlation between them remained significant after revising partial correlation analysis (r'=0.693,0.621,and 0.532,P<0.05).Hcy was influenced by miR-1 and miR-126 both in the Spearson correlation analysis (r=0.513,0.56,P<0.01) and partial correlation analysis (r'=0.599,0.614,P<0.05),but not by miR-208.Conclusion Hcy,miRNA (miR-1,miR-126 and miR-208) are independent risk factor for coronary heart disease and are increased along with stenosis of coronary arteries .%目的:结合冠状动脉狭窄程度,探讨冠心病患者血清同型半胱氨酸( Hcy)与微小RNA( miR-1、miR-126及miR-208)之间的相互关系。方法选取行冠脉造影术的患者共102名,根据造影结果分为对照组和观察组,检测Hcy、miR-1、miR-126及miR-208水平,同时对冠脉造影结果进行评价并计算Gensini积分,应用相关及线性回归分析Hcy、miRNA( miR-1、miR-126、miR-208)以及Gensini积分的相互关系。结果观察组血清Hcy、miRNA(miR-1、miR-126、miR-208)水平均

  18. 脑血管病患者208例实行康复护理%The recovery nursing methods on the brain blood vessel diseases patient

    Institute of Scientific and Technical Information of China (English)

    瞿红

    2000-01-01

    目的:探讨脑血管病实行康复护理,对脑血管后遗症偏瘫,功能障碍患者恢复的影响。方法:将208例脑血管病后遗症患者,实行康复护理措施,实施被动运动和主动运动,进行了肌力和活动能力测定。结果:经过6个月的康复护理,患者的肌力和活动能力明显好转。结论:康复护理对脑血管病后遗症患者的恢复功能,具有重要的意义。%Objective:To discuss the effects on the disorder with the recover nursing methods on the patients with the sequels of cere brovascular hemiparalysis.Methods:For 208 cases of the cerebrovascular sequelae's patients were practised with recoveryy nursing,the possessively motion and actively motion,compassed their muscle energy and motivate ability.Results:Passing through six month period of recoveryy nursing,the patient's muscle energy and action ability has been become better.Conclusion :The recover nursing has an important meaning to relieve sequelae of cerebrovascular.

  19. Accelerator driven neutron source design via beryllium target and (208)Pb moderator for boron neutron capture therapy in alternative treatment strategy by Monte Carlo method.

    Science.gov (United States)

    Khorshidi, Abdollah

    2017-01-01

    The reactor has increased its area of application into medicine especially boron neutron capture therapy (BNCT); however, accelerator-driven neutron sources can be used for therapy purposes. The present study aimed to discuss an alternative method in BNCT functions by a small cyclotron with low current protons based on Karaj cyclotron in Iran. An epithermal neutron spectrum generator was simulated with 30 MeV proton energy for BNCT purposes. A low current of 300 μA of the proton beam in spallation target concept via 9Be target was accomplished to model neutron spectrum using 208Pb moderator around the target. The graphite reflector and dual layer collimator were planned to prevent and collimate the neutrons produced from proton interactions. Neutron yield per proton, energy distribution, flux, and dose components in the simulated head phantom were estimated by MCNPX code. The neutron beam quality was investigated by diverse filters thicknesses. The maximum epithermal flux transpired using Fluental, Fe, Li, and Bi filters with thicknesses of 7.4, 3, 0.5, and 4 cm, respectively; as well as the epithermal to thermal neutron flux ratio was 161. Results demonstrated that the induced neutrons from a low energy and low current proton may be effective in tumor therapy using 208Pb moderator with average lethargy and also graphite reflector with low absorption cross section to keep the generated neutrons. Combination of spallation-based BNCT and proton therapy can be especially effective, if a high beam intensity cyclotron becomes available.

  20. Neutron-skin thickness of 208Pb, and symmetry-energy constraints from the study of the anti-analog giant dipole resonance

    CERN Document Server

    Krasznahorkay, A; Csige, L; Eriksen, T K; Giacoppo, F; Görgen, A; Hagen, T W; Harakeh, M N; Julin, R; Koehler, P; Paar, N; Siem, S; Stuhl, L; Tornyi, T; Vretenar, D

    2013-01-01

    The 208Pb(p,ngamma p)207Pb reaction at a beam energy of 30 MeV has been used to excite the anti-analog of the giant dipole resonance (AGDR) and to measure its gamma-decay of to the isobaric analog state. The energy of the transition has also been calculated with the self-consistent relativistic random-phase approximation (RRPA), and found to be linearly correlated to the predicted value of the neutron-skin thickness (DR_pn). By comparing the theoretical results with the measured transition energy, the value of 0.190 +- 0.028 fm has been determined for DR_pn of 208Pb, in agreement with previous experimental results. The AGDR excitation energy has also been used to calculate the symmetry energy at saturation (J=32.7+- 0.6 MeV) and the slope of the symmetry energy (L=49.7 +- 4.4 MeV), resulting in more stringent constraints than most of the previous studies.

  1. Grazing-induced changes in muscle microRNA-206 and -208b expression in association with myogenic gene expression in cattle.

    Science.gov (United States)

    Horikawa, Akihiko; Ogasawara, Hideki; Okada, Kaito; Kobayashi, Misato; Muroya, Susumu; Hojito, Masayuki

    2015-11-01

    To investigate the roles of microRNAs (miRNAs) in muscle type conversion, the effects of 4 months of grazing on the expression levels of miRNAs and mRNAs associated with skeletal muscle development were analyzed by quantitative RT-PCR using the Biceps femoris muscle of Japanese Shorthorn cattle. After 4 months of grazing, the expression of muscle fiber type-associated miR-208b was higher in the grazed cattle than in the housed. In concordance with the pattern in miR-208b expression, the expression of MyoD, a myogenic regulatory factor associated with the shifting of muscle property to the fast type, was lower in the grazed cattle after 4 months of grazing than in the housed cattle. In addition, the expression of MyHC-2x (a fast type) was higher in the housed cattle than in the grazed, after 4 months of grazing. During the grazing period, miR-206 expression decreased in the housed cattle, whereas expression in the grazed cattle did not change, but rather remained higher than that of the housed cattle even at 3 months after the grazing ended. These miRNAs including miR-206 persisting with muscles of grazed cattle may be associated with regulation of muscle gene expression during skeletal muscle adaptation to grazing.

  2. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-8 and ER-20-4, Nevada National Security Site, Nye County, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Greg Ruskauff and Sam Marutzky

    2012-09-01

    Wells ER-20-4 and ER-20-8 were drilled during fiscal year (FY) 2009 and FY 2010 (NNSA/NSO, 2011a and b). The closest underground nuclear test detonations to the area of investigation are TYBO (U-20y), BELMONT (U-20as), MOLBO (U-20ag), BENHAM (U-20c), and HOYA (U-20 be) (Figure 1-1). The TYBO, MOLBO, and BENHAM detonations had working points located below the regional water table. The BELMONT and HOYA detonation working points were located just above the water table, and the cavity for these detonations are calculated to extend below the water table (Pawloski et al., 2002). The broad purpose of Wells ER-20-4 and ER-20-8 is to determine the extent of radionuclide-contaminated groundwater, the geologic formations, groundwater geochemistry as an indicator of age and origin, and the water-bearing properties and hydraulic conditions that influence radionuclide migration. Well development and testing is performed to determine the hydraulic properties at the well and between other wells, and to obtain groundwater samples at the well that are representative of the formation at the well. The area location, wells, underground nuclear detonations, and other features are shown in Figure 1-1. Hydrostratigraphic cross sections A-A’, B-B’, C-C’, and D-D’ are shown in Figures 1-2 through 1-5, respectively.

  3. In vitro screening of reversible and time-dependent inhibition on CYP3A by TM208 and TM209 in rat liver microsomes

    Directory of Open Access Journals (Sweden)

    Miaoran Ning

    2012-04-01

    Full Text Available TM208 and TM209, dithiocarbamate derivatives with potential anti-cancer effects, were evaluated in reversible and time-dependent cytochrome P450 (CYP 3A inhibition assays in rat liver microsomes using testosterone as probe substrate. Both compounds were found to be weak reversible inhibitors and moderate mechanism-based inhibitors of rat CYP3A. For reversible inhibition on rat CYP3A, the Ki values of competitive inhibition model were 12.10±1.75 and 13.94±1.31 μM, respectively. For time-dependent inhibition, the inactivation constants (Kl were 31.93±12.64 and 32.91±15.58 μM, respectively, and the maximum inactivation rates (kinact were 0.03497±0.0069 and 0.07259±0.0172 min−1 respectively. These findings would provide useful in vitro information for future in vivo DDI studies on TM208 or TM209.

  4. Final evaluation report for Westinghouse Hanford Company, WRAP-1,208 liter waste drum, docket 94-35-7A, type A packaging

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, D.L., Westinghouse Hanford

    1996-06-12

    This report documents the U.S. Department of Transportation Specification 7A Type A (DOT-7A) compliance test results of the Westinghouse Hanford Company, Waste Receiving and Processing Facility, Module 1 (WRAP-1) Drum. The WRAP-1 Drum was tested for DOE-HQ in August 1994, by Los Alamos National Laboratory, under docket number 94-35-7A. Additionally, comparison and evaluation of the approved, as-tested packaging configuration was performed by WHC in September 1995. The WRAP-1 Drum was evaluated against the performance of the DOT-17C, 208 1 (55-gal) steel drums tested and evaluated under dockets 89-13-7A/90-18-7A and 94-37-7A.

  5. Study of two- and multi-particle correlations in 12C+24Mg and 12C+208Pb reactions at E=35 AMeV

    Directory of Open Access Journals (Sweden)

    Quattrocchi L.

    2016-01-01

    Full Text Available Two and multi particle correlations from the decay of sources produced in 12C+24Mg and 12C+208Pb collisions at E=35 AMeV have been studied by using the forward part (1° < θlab < 30° of the CHIMERA multi-detector. Correlations and invariant mass spectroscopy are used to explore simultaneous and sequential decays of resonances in light isotopes with Z∼3-6, produced in peripheral collisions via the break-up of excited quasi-projectiles. Among them we mention 5Li, 6Li, 6Be, 8Be and the astrophysically important state in 12C decaying into three alpha particles. Results and future perspectives at the INFN-LNS will be presented.

  6. Mapping the boundaries of the seniority regime and collective motion: Coulomb excitation studies of N = 122 isotones $^{206}$Po and $^{208}$Rn

    CERN Multimedia

    Butler, P; Voulot, D; Rahkila, P J; Darby, I G; Grahn, T; Bree, N C F; Julin, R J; Diriken, J V J; Jenkins, D G; Kroell, T; Huyse, M L

    In regions near magic nuclei, seniority can be regarded as a good quantum number. In the N = 122 isotones above the Z = 82 shell closure relative high-$\\textit{j}\\,$ single-particle proton orbitals dominate the structure and thus levels up to $\\textit{I}$ = 2$\\textit{j}$ - 1 could, in principle, be understood within the seniority scheme. While B(E2) values usually increase within the band with increasing $\\textit{I}$, the seniority scheme can lead to a contrasting result. The present proposal addresses this phenomenon through the measurements of previously unknown B(E2; 0$^{+}\\rightarrow$ 2$^{+}$) values in $^{206}$Po and $^{208}$Rn. The proposed Coulomb excitation measurements of radioactive beams will be carried out at the REX-ISOLDE facility using the MINIBALL $\\gamma$-ray spectrometer.

  7. Measurement of hadron and lepton-pair production in $e^{+}e^{-}$ collisions at $\\sqrt{s} = 192 - 208 GeV$ at LEP

    CERN Document Server

    Achard, P; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Anderhub, H; Andreev, V P; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, G; Baksay, L; Baldew, S V; Banerjee, S; Banerjee, S W; Barczyk, A; Barillère, R; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biglietti, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, G J; Böhm, A; Boldizsar, L; Borgia, B; Bottai, S; Bourilkov, D; Bourquin, M; Braccini, S; Branson, J G; Brochu, F; Burger, J D; Burger, W J; Cai, X D; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A; Casaus, J; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada, M; Chamizo-Llatas, M; Chang, Y H; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, L; Cindolo, F; Clare, I; Clare, R; Coignet, G; Colino, N; Costantini, S; de la Cruz, B; Cucciarelli, S; De Asmundis, R; Deglon, P; Debreczeni, J; Degré, A; Dehmelt, K; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Dionisi, C; Dittmar, M; Doria, A; Dova, M T; Duchesneau, D; Duda, M; Echenard, B; Eline, A; El-Hage, A; El-Mamouni, H; Engler, A; Eppling, F J; Extermann, P; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, M; Ferguson, T; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, F; Fisher, P H; Fisher, W; Forconi, G; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gentile, S; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hirschfelder, J; Hofer, H; Hohlmann, M; Holzner, G; Hou, S R; Jin, B N; Jindal, P; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kaur, M; Kienzle-Focacci, M N; Kim, J K; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Kopal, M; Koutsenko, V F; Kraber, M; Krämer, R W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Le Goff, J M; Leiste, R; Levtchenko, M; Levchenko, P M; Li, C; Likhoded, S; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Luci, C; Luminari, L; Lustermann, W; Ma, W G; Malgeri, L; Malinin, A; Maña, C; Mans, J; Martin, J P; Marzano, F; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Muanza, G S; Muijs, A J M; Musy, M; Nagy, S; Natale, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nisati, A; Novák, T; Nowak, H; Ofierzynski, R A; Organtini, G; Pal, I; Palomares, C; Paolucci, P; Paramatti, R; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, F; Pedace, M; Pensotti, S; Perret-Gallix, D; Piccolo, D; Pierella, F; Pieri, M; Pioppi, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Pothier, J; Prokofev, D; Prokofiev, D O; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A V; Razis, P; Rembeczki, S; Ren, D; Rescigno, M; Reucroft, S; Riemann, S; Riles, K; Roe, B P; Romero, L; Rosca, A; Rosemann, C; Rosenbleck, C; Rosier-Lees, S; Roth, S; Rubio, J A; Ruggiero, G; Rykaczewski, H; Sakharov, A; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Schäfer, C; Shchegelskii, V; Schopper, Herwig Franz; Schotanus, D J; Sciacca, C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A; Son, D; Souga, C; Spillantini, P; Steuer, M; Stickland, D P; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S; Suter, H; Swain, J D; Szillási, Z; Tang, X W; Tarjan, P; Tauscher, L; Taylor, L; Tellili, B; Teyssier, D; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Ulbricht, J; Valente, E; Van de Walle, R T; Vásquez, R; Vesztergombi, G; Vetlitskii, I; Viertel, G; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Wadhwa, M; Wang, Q; Wang, X L; Wang, Z M; Weber, M; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhao, J; Zhu, G Y; Zhu, R Y; Zhuang, H L; Zichichi, A; Zimmermann, B; Zöller, M

    2006-01-01

    Hadron production and lepton-pair production in e+e- collisions are studied with data collected with the L3 detector at LEP at centre-of-mass energies sqrt{s}=192-208GeV. Using a total integrated luminosity of 453/pb, 36057 hadronic events and 12863 lepton-pair events are selected. The cross sections for hadron production and lepton-pair production are measured for the full sample and for events where no high-energy initial-state-radiation photon is emitted prior to the collisions. Lepton-pair events are further investigated and forward-backward asymmetries are measured. Finally, the differential cross sections for electron-positron pair-production is determined as a function of the scattering angle. An overall good agreement is found with Standard Model predictions.

  8. Long-term Bone Remodeling in HA-coated Stems: A Radiographic Review of 208 Total Hip Arthroplasties (THAs) with 15 to 20 Years Follow-up.

    Science.gov (United States)

    Boldt, Jens G; Cartillier, Jean-Claude; Machenaud, Alain; Vidalain, Jean-Pierre

    2015-11-01

    We present a prospective study focused on radiographic long-term outcomes and bone remodeling at a mean of 17.0 years (range: 15 to 20) in 208 cementless fully HA-coated femoral stems (Corail, DePuy International Ltd, Leeds, UK). Total hip replacements in this study were performed by three members of the surgeon design group between 1986 and 1991. Radiographic evaluation focused on periprosthetic osteolysis, bone remodeling, osseous integration, subsidence, metaphyseal or diaphyseal load transfer, and femoral stress shielding. The radiographs were digitized and examined with contrast-enhancing software for analysis of the trabecular architecture. Radiographic signs of aseptic stem loosening were visible in two cases (1%). Three stems (1.4%) showed metaphyseal periprosthetic osteolysis in four of seven Gruen zones associated with eccentric polyethylene wear awaiting metaphyseal bone grafting and cup liner exchange. One stem (0.5%) was revised due to infection. No stem altered in varus or valgus alignment more than two degrees, and mean subsidence was 0.1 mm (range: 0 to 2 mm) after a mean of 17.0 years. A total of 5 stems (2.4%) required or are awaiting revision surgery. Trabecular orientation and micro-anatomy suggested main proximal load-transfer patterns in all except 3 cases (98.6%). Combined metaphyseal and diaphyseal osseointegration and bone remodeling were visible in 100 stems (48%). Diaphyseal stress shielding and cortical thickening were observed in 3 stems (1.4%). Other radiographic features are discussed in depth. This long-term study of 208 fully HA-coated Corail stems showed satisfactory osseointegration and fixation in 203 cases (97.6%) after a mean of 17.0 years follow-up. Stem failures were associated with extreme eccentric polyethylene wear.

  9. 复方氟米松软膏联合液氮冷冻治疗疥疮结节208例疗效观察%Treatment effect observation of 208 patients with scabies tubercle treated with Compound Flumetasone Ointment combined with liquid nitrogen cryotherapy

    Institute of Scientific and Technical Information of China (English)

    刘诗; 张东兴; 赖洪涛; 姚明珠; 曾远娟

    2013-01-01

    Objective: To observe the clinical treatment effects of Compound Flumetasone Ointment Combined with liquid nitrogen cryotherapy on scabies tubercle. Methods: 410 patients with scabies tubercle in section for outpatients in our department were col ected and randomly divided into two groups, the control group and the observation group. 202 patients in the control group were treated with Compound Flumetasone Ointment, and 208 patients in the observation group were treated with Compound Flumetasone Ointment combined with liquid nitrogen cryotherapy. The treatment effects in the two groups were observed. Results: The total effective rate in the observation group with 208 patients was 94.71%, and the total effective rate in the control group with 202 patients was 87.50%. There were significances in respect to total effective rate in the two groups (p<0.05). Conclusion: Significant treatment effects could be achieved in clinical application for the treatment of Compound Flumetasone Ointment Combined with liquid nitrogen cryotherapy, which have better treatment effects than that of single treatment with Compound Flumetasone Ointment or liquid nitrogen cryotherapy.%目的观察复方氟米松软膏联合液氮冷冻治疗疥疮结节的临床疗效。方法选取我科门诊的410例疥疮结节患者,随机分成2组,对照组202例采用外涂复方氟米松软膏治疗,观察组208例在对照组基础上加用液氮冷冻治疗,对两组治疗效果进行观察分析。结果观察组208例患者中,总有效率为94.71%;对照组200例患者中,总有效率为87.50%。两组总有效率相比具有显著性(p<0.05)。结论使用复方氟米松软膏联合液氮冷冻治疗可在临床上收到显著的疗效,比单一治疗方法效果更好。

  10. 两个γTrp208Leu杂合突变导致的遗传性低纤维蛋白原血症家系表型和基因型分析%Analysis of phenotype and genotype in two Chinese pedigrees with inherited hypoifbrinogenemia caused by γTrp208Leu

    Institute of Scientific and Technical Information of China (English)

    杨丽红; 郝秀萍; 丁红香; 金艳慧; 江明华; 王明山

    2015-01-01

    目的:对由同一突变位点导致的两个遗传性低纤维蛋白原血症家系进行临床表型和基因型分析,探讨其分子发病机制。方法:检测两个家系所有成员的血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤溶酶原活性(PLG:C)和纤维蛋白(原)降解产物(FDPs),分别采用Clauss法与免疫比浊法测定血浆纤维蛋白原活性(Fg:C)和抗原(Fg:Ag)水平。提取DNA,PCR扩增Fg的FGA、FGB和FGG基因所有外显子和侧翼序列,PCR产物纯化后测序进行基因分析。采用Swiss-Model和PIC软件对突变位点进行蛋白模型和氨基酸相互作用的分析。结果:两家系先证者PT、APTT以及纤溶指标(PLG:C和FDPs)均在正常范围内,TT轻度延长;Fg:C明显降低,分别为0.49 g/L和0.63 g/L;Fg:Ag同步下降,分别为0.64 g/L和0.77 g/L。先证者A的奶奶和父亲,先证者B的母亲、阿姨和表弟,Fg:C和Fg:Ag均有不同程度降低。基因分析发现2例先证者FGG基因第7号外显子5792位发生G>T杂合错义突变,导致Fg γD结构域的208位色氨酸突变为亮氨酸(γTrp208Leu)。模型分析显示γTrp208Leu突变破坏了Trp208与Thr314间的天然氢键连接,并使该位点氨基酸侧链变短,空间构型改变,使突变蛋白稳定性下降。结论:纤维蛋白原FGG基因γTrp208Leu杂合错义突变是导致该两个遗传性低纤维蛋白原血症的原因。%Objective: To analyze the phenotype and genotype of two Chinese pedigrees with inherited hypoifbrinogenemiaidentify by the same mutation.Methods: Laboratory tests, including prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), plasminogen activity (PLG:C), and ifbrinogen degradation products (FDPs) were detected in two pedigrees. The activity and antigen plasma ifbrinogen (Fg:C, Fg:Ag) were analyzed by Clauss and

  11. Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves’ Disease Study

    Directory of Open Access Journals (Sweden)

    Peter Laurberg

    2014-01-01

    Full Text Available Background. Graves’ disease may have a number of clinical manifestations with varying degrees of activity that may not always run in parallel. Objectives. To study associations between serum levels of TSH-receptor autoantibodies and the three main manifestations of Graves’ disease (hyperthyroidism, goiter, and presence of orbitopathy at the time of diagnosis of hyperthyroidism. Methods. We describe a cohort of 208 patients with newly diagnosed Graves’ hyperthyroidism. Patients were enrolled in a multiphase study of antithyroid drug therapy of Graves’ hyperthyroidism, entitled “Remission Induction and Sustenance in Graves’ Disease (RISG.” Patients were systematically tested for degree of biochemical hyperthyroidism, enlarged thyroid volume by ultrasonography, and the presence of orbitopathy. Results. Positive correlations were found between the levels of TSH-receptor autoantibodies in serum and the three manifestations of Graves’ disease: severeness of hyperthyroidism, presence of enlarged thyroid, and presence of orbitopathy, as well as between the different types of manifestations. Only around half of patients had enlarged thyroid gland at the time of diagnosis of hyperthyroidism, whereas 25–30% had orbitopathy. Conclusions. A positive but rather weak correlation was found between TSH-receptor antibodies in serum and the major clinical manifestation of Graves’ disease. Only half of the patients had an enlarged thyroid gland at the time of diagnosis.

  12. Excitation functions of residual nuclei production from 40–2600 MeV proton-irradiated 206,207,208,natPb and 209Bi

    Indian Academy of Sciences (India)

    Yu E Titarenko; V F Batyaev; V M Zhivun; V O Kudryashov; K A Lipatov; A V Ignatyuk; S G Mashnik

    2007-02-01

    The work is aimed at experimental determination of the independent and cumulative yields of radioactive residual nuclei produced in intermediate-energy proton-irradiated thin targets made of highly isotopic enriched and natural lead (206,207,208,natPb) and 209Bi. 5972 radioactive product nuclide yields have been measured in 55 thin targets induced by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6 and 2.6 GeV protons extracted from the ITEP U-10 proton synchrotron. The measured data have been compared with data obtained at other laboratories as well as with theoretical simulations by seven codes. We found that the predictive power of the tested codes is different but is satisfactory for most of the nuclides in the spallation region, though none of the codes agree well with the data in the whole mass region of product nuclides and all should be improved further.

  13. Urea Cycle Defects: Early-Onset Disease Associated with A208T Mutation in OTC Gene—Expanding the Clinical Phenotype

    Science.gov (United States)

    Sánchez, Ana Isabel; Rincón, Alejandra; García, Mary

    2017-01-01

    Ornithine transcarbamylase deficiency (OMIM: 311250) is the most common disorder of urea cycle disorders, accounting for nearly 50% of all cases. We report a case of a two-month- old male patient, who attends our medical genetics consultation because of low citrulline levels and elevated glutamine to citrulline ratio detected by expanded newborn screening with tandem mass spectrometry. He is an asymptomatic male with a normal physical examination and appropriate neurodevelopmental milestones. The patient has a family history of one older brother who died at 18 months old from severe and sudden hyperammonemia and a maternal aunt who suddenly died at two years old. He had high plasma ammonium concentration and a confirmed OTC mutation (p.A208T). Usually, this mutation causes OTC deficiency of late onset in adult males. However, this report raises awareness about mutations previously described as a late-onset causing disease, which can cause severe hyperammonemia and high risk of dying at an early age. PMID:28261508

  14. Reaction 48Ca+208Pb: the capture-fission cross-sections and the mass-energy distributions of fragments above and deep below the Coulomb barrier

    CERN Document Server

    Prokhorova, E V; Itkis, M G; Kondratev, N A; Kozulin, E M; Krupa, L; Oganessian, Yu T; Pashkevich, V V; Pokrovsky, I V; Rusanov, A Ya; Oganessian, Yu.Ts.

    2003-01-01

    The capture-fission cross-sections in an energy range of 206-242 MeV of 48Ca-projectiles and mass-energy distributions (MEDs) of reaction products in an energy range of 211-242 MeV have been measured in the 48Ca+208Pb reaction using the double-arm time-of-flight spectrometer CORSET. The MEDs of fragments for heated fission were shown to consist of two components. One component, which is due to classical fusion-fission, is associated with the symmetric fission of the 256No compound nucleus. The other component, which appears as ''shoulders'', is associated with the quasi-fission process and can be named ''quasi-fission shoulders''. Those quasi-fission shoulders enclose light fragments whose masses are 60-90 a.m.u. The total kinetic energy (TKE) of the fragments that belong to the shoulders is higher than the value expected for a classical fusion-fission process. We have come to the conclusion that in quasi-fission, spherical shells with Z=28 and N=50 play a great role. It has also been demonstrated that the pr...

  15. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-7, ER-20-8 #2, and ER-EC-11, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Greg Ruskauff

    2011-12-01

    This report analyzes the following data collected from ER-20-7, ER-20-8 No.2, and ER-EC-11 during WDT operations: (1) Chemical indicators of well development (Section 2.0); (2) Static hydraulic head (Section 3.0); (3) Radiochemistry and geochemistry (Section 4.0); (4) Drawdown observed at locations distal to the pumping well (Section 5.0); and (5) Drilling water production, flow logs, and temperature logs (Section 6.0). The new data are further considered with respect to existing data as to how they enhance or change interpretations of groundwater flow and transport, and an interim small-scale conceptual model is also developed and compared to Phase I concepts. The purpose of well development is to remove drilling fluids and drilling-associated fines from the formation adjacent to a well so samples reflecting ambient groundwater water quality can be collected, and to restore hydraulic properties near the well bore. Drilling fluids can contaminate environmental samples from the well, resulting in nonrepresentative measurements. Both drilling fluids and preexisting fines in the formation adjacent to the well can impede the flow of water from the formation to the well, creating artifacts in hydraulic response data measured in the well.

  16. The same mutation Glu208Lys in the GJB1 gene was detected in 2 families with X-linked Charcot-Marie-Tooth Disease%在两个X连锁显性腓骨肌萎缩症家系中发现同一GJB1基因突变Glu208Lys

    Institute of Scientific and Technical Information of China (English)

    宋书娟; 闫明; 王小竹; 章远志; 邹俊华; 钟南

    2007-01-01

    在两个X连锁显性腓骨肌萎缩症(Charcot-Marie-Tooth disease,CMT)家系中进行了GJB1基因的突变分析.提取基因组DNA,PCR(polymerase chain reaction)反应扩增GJBl基因编码序列,进行单链构象多态性(singlestrand conformational polymorphism,SSCP)分析,对有差异SSCP带型的PCR产物进行测序,结果在两家系中发现同一GJBl基因c.622G→A(GIu208Lys)突变.所发现的突变位点在国内尚未报道.

  17. Analysis of 208 case of labor induction of mid-term pregnant women by Taking Mifepristone and Misoprostol%米非司酮配伍米索前列醇用于中期妊娠引产208例分析

    Institute of Scientific and Technical Information of China (English)

    张先艳; 梁莉; 沙志萍

    2002-01-01

    目的:探讨对13~20周中期妊娠的孕妇用米非司酮配伍米索前列醇引产的效果.方法:对208例妊娠13~20周的孕妇采用空腹口服米非司酮加服米索前列醇.结果:胎儿及胎盘自然排出者199例,成功率95.7%.结论:此方法引产成功率高、并发症少,安全有效,产妇痛苦明显减轻.

  18. Study of elastic pion scattering from /sup 9/Be, /sup 28/Si, /sup 58/Ni, and /sup 208/Pb at 162 MeV. [Total and differential cross sections, scattering yields, scattering amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Devereux, M.J.

    1979-05-01

    Elastic pion scattering from /sup 9/Be, /sup 28/Si, /sup 58/Ni, and /sup 208/Pb at 162 MeV is analyzed and compared with an optical model theory which incorporates a pion--nucleon range. Excellent fits to the data are obtained in all but one case. The fitted values of the pion--nucleon range, as well as other fitted values are listed. 108 references.

  19. Isomeric ratios for nuclei with Z=62-67 and A=142-152 produced in the relativistic fragmentation of 208Pb

    Energy Technology Data Exchange (ETDEWEB)

    Myalski, Szymon; Maj, Adam [IFJ PAN, Krakow (Poland); Podolyak, Zsolt [Dept. of Physics, Univ. of Surrey, Guildford (United Kingdom)

    2009-07-01

    We have investigated isomeric states in a number of nuclei with Z=62-67 and A=142-152, produced by the fragmentation of the relativistic(1 GeV/u) {sup 208}Pb beam from the SIS-18 synchrotron of the GSI facility on a {sup 9}Be target, and selected by the FRagment Separator(FRS). The selected nuclei of interest were implanted into the stopper, a block of plastic 7mm thick. The gamma-rays from the decay of isomeric states in the implanted nuclei were measured by the high purity germanium array, RISING. In total 22 nuclides were detected, isomeric states were observed in 9 of them:19{sup -} in {sup 152}Ho, 31/2{sup +} in {sup 153}Ho, 27{sup +} in {sup 148}Tb, 10{sup +}in {sup 144}Gd, 49/2{sup +}in {sup 147}Gd, 11/2{sup -} in {sup 143}Eu, 8{sup -} in {sup 144}Eu, 11/2{sup -} in {sup 145}Eu, 10{sup +} in {sup 142}Sm and 7{sup -} in {sup 142}Sm. Of special interest is the 27{sup +} state in {sup 148}Tb, the highest spin populated through the fragmentation reaction until present day. The aim of this work was the extraction of isomeric ratios(R) for these isomeric states. The R is the number of ions populated in a given isomeric state compared to the total number of ions populated for the selected nuclide. The R can provide information about the production reaction and nuclear structure. It was evaluated based on flight time, half-life, in-flight losses and by considering the finite measurement time. Results were compared with theoretical predictions, calculated using an abrasion-ablation approach.

  20. Performance of potential non-crop or wild species under OECD 208 testing guideline study conditions for terrestrial non-target plants.

    Science.gov (United States)

    Pallett, Ken; Cole, Jon; Oberwalder, Christian; Porch, John

    2007-02-01

    The inclusion of 52 potential non-crop or wild species in new OECD guidelines for terrestrial non-target plant (TNTP) testing led to a ring test conducted by four laboratories experienced in regulatory testing. Species selected had shown potential to meet validity criteria of emergence for TNTP studies in a previous evaluation of the 52 species. OECD 208 guideline conditions were applied, with and without seed pretreatments recommended to enhance germination. These species were Abutilon theophrasti (L.) Medic., Avena fatua L., Fallopia convolvulus (L.) Adans., Galium aparine L., Ipomoea hederacea (L.) Jacq. and Veronica persica Poir. Only I. hederacea met the validity criterion of 70% emergence in all laboratories and showed a low variability in biomass. Of the other species, none led to 70% emergence in all four laboratories. The recommended pretreatments did not have a major impact on emergence. Biomass was also investigated with A. theophrasti, A. fatua, Centaurea cyanus L., I. hederacea and Rumex crispus L. Variability of biomass, a key parameter in TNTP regulatory studies, exceeded normal biomass variability of crop species used for TNTP studies. The addition of a thin layer of quartz sand to the soil surface resulted in improved emergence of C. cyanus, G. aparine and V. persica; however, such a procedure, while routine in screening studies to improve germination, is a deviation from the TNTP guidelines. These initial studies indicate that some species could meet the emergence criteria for TNTP testing. However, there is a need for further studies on seed source, seed quality and conditions for uniform emergence before their use in routine regulatory testing.

  1. Commissioning of the STAR test section for experimental simulation of loss of coolant accident using the EC-208 instrumented fuel assembly of the IEA-R1 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Maprelian, Eduardo; Torres, Walmir M.; Prado, Adelk C.; Umbehaun, Pedro E.; Franca, Renato L.; Santos, Samuel C.; Macedo, Luiz A.; Sabundjian, Gaiane, E-mail: emaprel@ipen.br, E-mail: wmtorres@ipen.br, E-mail: acprado@ipen.br, E-mail: umbehaun@ipen.br, E-mail: rlfranca@ipen.br, E-mail: samuelcs@ipen.br, E-mail: lamacedo@ipen.br, E-mail: gdjian@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SO (Brazil)

    2015-07-01

    The three basic safety functions of Research Reactors (RR) are the safe shutdown of the reactor, the proper cooling of the decay heat of the fuel elements and the confinement of radioactive materials. Compared to Nuclear Power Reactors, RR power release is small, yet its three safety functions must be met to ensure the integrity of the reactor. During a loss of coolant accident (LOCA) in pool type RR, partial or complete loss of pool water may occur, with consequent partial or complete uncovering of the fuel assemblies. In such an accident, the decay heat removal safety function must not be compromised. The Test Section for Experimental Simulation of Loss of Coolant Accident (STAR) is in commissioning phase. This test section will provide experimental data on partial and total uncovering of the EC-208 instrumented fuel assembly (IFA) irradiated in the IEA-R1. Experimental results will be useful in validation of computer codes for RR safety analysis, particularly on heat removal efficiency aspects (safety function) in accident conditions. STAR comprises a base on which is installed the IFA, the cylindrical stainless steel hull, the compressed air system for the test section emptying and refilling, and the instrumentation for temperature and level measurements. The commissioning tests or pre-operational check, consist of several preliminary tests to verify experimental procedures, the difficulties during assembling of STAR in the pool, the difficulties in control the emptying and refilling velocities, as well as, the repeatability capacity, tests of equipment, valves and systems and tests of instrumentation and data acquisition system. Safety, accuracy and easiness of operation will be checked. (author)

  2. Allanite from the El Muerto Pegmatite, Oaxaca, Mexico: A Potential New Standard for 232Th-208Pb Dating by LA-ICP-MS

    Science.gov (United States)

    Price, J.; Crowley, J. L.; Solari, L.; Prol-Ledesma, R.

    2012-12-01

    Allanite dating may be important to studies addressing tectonomagmatic evolution, provenance of monocyclic sediment, and mineral weathering. Obtaining accurate allanite ages by SIMS has been challenging and time-consuming due to the mineral's extreme chemical variability which often prevents finding adequately matrix-matched standards. Isotopic measurements by LA-ICP-MS minimize the need for standards of nearly identical composition to the unknown allanite being analyzed, and it is done relatively rapidly. Dating by LA-ICP-MS requires high quality standards for isotopic fractionation corrections. However, readily accessible and well characterized allanite standards are scarce. We investigated gemstone allanite from the El Muerto pegmatite, Oaxaca, Mexico, as a potential new geochronology standard for 232Th-208Pb allanite dating by LA-ICP-MS. Compositional homogeneity was thoroughly investigated by scanning and backscatter electron microscopy, cathodoluminescence, quantitative and qualitative energy dispersive x-ray spectroscopy, electron microprobe, and LA-ICP-MS. The possibility of metamictization was investigated by extensive X-ray diffraction analyses. The El Muerto allanite was U-Pb dated by ID-TIMS, with common Pb ratios determined from cogenetic K-feldspar by ID-TIMS and LA-MC-ICP-MS. Future work includes Th-Pb dating by ID-TIMS. The samples investigated are homogeneous with respect to major and trace elements. Major element compositional results are generally in agreement with published values, and no metamictization was identified despite the allanite being nearly 1 Ga. The only limitation of the El Muerto allanite is that it contains small, generally <100 μm, scarce inclusions of quartz, calciothorite, albite, calcite, and biotite. However, these grains are easily recognized and avoided during LA-ICP-MS analyses. Based on these results, the El Muerto allanite has the potential to serve as a standard for LA-ICP-MS dating.

  3. AMENDAMENTELE OPERATE ÎN CODUL CONTRAVENȚIONAL PRIN LEGEA NR. 208/2016: IMPLICAȚII JURIDICO-PENALE

    Directory of Open Access Journals (Sweden)

    Sergiu BRÎNZA

    2017-07-01

    Full Text Available Scopul investigației de față îl constituie analiza implicațiilor juridico-penale ale amendamentelor operate prin Legea nr.208/2016. Analiza efectuată arată că modificarea operată în alin.(6 art.16 din Codul contravențional a îndepărtat în plan terminologic Codul contravențional de Codul penal. Din aceleași considerente, este inoportună modificarea alin.(4 art.17 din Codul contravențional. În același timp, se prezintă ca oportună modificarea art.18 din Codul contravențional. De asemenea, se justifică modificarea cu caracter de precizare a art.541 din Codul contravențional. La fel, este salutară modificarea alin.(1 și (2 art.96, art.97, alin.(1 și (2 art.971, art.972, art.99-103, art.149, alin.(2 art.155 și a art.243 din Codul contravențional. Totuși, acestea nu sunt singurele norme contravenționale care se află într-o relație de comple­men­­taritate cu anumite norme penale. De aceea, legiuitorul ar trebui să dea dovadă de mai multă consecvență și să abordeze uniform ipotezele similare care vizează complementaritatea dintre ilicitul penal și ilicitul contravențional. Este oportună completarea dispoziției alin.(10 art.157 din Codul contravențional, în final, cu textul „ , dacă fapta nu constituie infrac­țiune,”. Aceasta va permite delimitarea mai precisă a faptei contravenționale prevăzute de această normă de unele infrac­țiuni. Se justifică completarea Codului contravențional cu art.1991-19912, 2201-2205. Aceste norme au completat lista de norme contravenționale care sunt complementare față de art.263 CP RM. Este oportună excluderea sintagmei „încalcă normele morale,” din dispoziția art.354 din Codul contravențional.THE AMENDMENTS MADE TO THE CONTRAVENTION CODE BY LAW NO.208/2016: JURIDICAL-PENAL CONSIDERATIONSThe purpose of the investigation is to analyze the juridical-penal considerations of the amendments made by Law No.208/2016. As a result of the analysis there

  4. Evaluation and analysis of rationality of cefoxitin sodium for injection in 208 patients in our hospital%我院208例患者使用注射用头孢西丁钠的合理性评价与分析

    Institute of Scientific and Technical Information of China (English)

    梁建翁

    2015-01-01

    目的了解惠州市第六人民医院住院患者使用注射用头孢西丁钠的情况, 为头孢西丁钠的临床合理使用与管理提供参考.方法采用回顾性调查方法, 调取普外科、妇科、产科、呼吸科、骨科、五官科、手外科7个科室使用头孢西丁钠的出院患者有效病历208例, 并参考相关标准评价注射用头孢西丁钠临床应用的合理性.结果有效病历中内科治疗用药38例, 外科围手术期预防用药26例, 外科治疗用药144例, 不符合给药剂量的有20例, 不符合时间标准者22例, 不符合适应证标准者15例.注射用头孢西丁钠临床使用合理性的综合判断结果为用药合理者168例, 不合理40例.结论本院注射用头孢西丁钠的临床使用情况基本合理, 但还需加强管理.%ObjectiveTo understand application of cefoxitin sodium for injection in patients of Huizhou city the sixth people's hospital, in order to provide reference for clinical rational use and management of cefoxitin sodium.MethodsA retrospective analysis was made on 208 effective cases receiving cefoxitin sodium in departments of general surgery, gynecology, obstetrics, respiration, orthopaedics, and hand surgery. Rationality of cefoxitin sodium for injection in clinical application was evaluated by relevant standard.ResultsThere were 38 cases of drug therapy in internal medicine, 26 cases of perioperative drug prevention in surgery, 144 cases of drug therapy in surgery, 20 cases of unqualified drug dose, 22 cases of unqualified drug time, and 15 cases of unqualified indication standard. The comprehensive judgment result of clinical rationality of cefoxitin sodium for injection included 168 rational administration cases and 40 irrational cases.ConclusionApplication of cefoxitin sodium for injection is basically rational in our hospital, which it is necessary for strengthened management.

  5. Observation on the therapeutic effect of Budesonide combined with Terbutaline inhalation via oxygen-driven atomization in treatment of 208 children capillarity bronchitis and nursing care%布地奈德联合特布他林气动雾化吸入治疗小儿毛细支气管炎208例疗效观察与护理

    Institute of Scientific and Technical Information of China (English)

    张家秀

    2012-01-01

    目的:探讨布地奈德联合特布他林气动雾化吸入治疗小儿毛细支气管炎的疗效与护理方法.方法:将312例毛细支气管炎患儿随机分为治疗组208例和对照组104例,对照组采用抗感染、止咳、平喘、化痰等综合性治疗,治疗组在此基础上加用布地奈德联合特布他林雾化液气动雾化吸入,比较两组疗效.结果:治疗组显效率高于对照组(P<0.05),喘憋及哮鸣音消失时间、住院时间短于对照组(P<0.01).结论:布地奈德联合特布他林气动雾化治疗毛细支气管炎能缩短病程,减轻患儿痛苦,减少并发症发生.%Objective: To investigate the therapeutic effect of Budesonide combined with Terbutaline inhalation via oxygen - driven at-omization in treatment of children capillarity bronchitis and nursing methods. Methods: 312 children patients with capillarity bronchitis were randomly divided into a treatment group( n = 208 )and a control group( n = 104 ). The comprehensive treatment like anti - infection, reliving cough and asthma and resolving phlegm was given to the patients in the control group and the patients in the treatment group received extra treatment with Budesonide combined with Terbutaline inhalation via oxygen - driven atomization based on the comprehensive treatment. The therapeutic effect was compared between the two groups. Results: The therapeutic effect in the treatment group was more efficient than the control group( P<0. 05 ); the disappearance time of breathlessness, wheezing and hospitalization time was shorter in the treatment group than the control group( P <0. 01 ). Conclusion: Budesonide combined with Terbutaline inhalation via oxygen - driven atomization in treatment of children capillarity bronchitis can shorten the course of disease, relieve childrens sufferings and reduce the occurrence of complications.

  6. Solution of the Skyrme Hartree Fock Bogolyubov equations in the Cartesian deformed harmonic-oscillator basis. (V) HFODD(v2.08k)

    Science.gov (United States)

    Dobaczewski, J.; Olbratowski, P.

    2005-05-01

    We describe the new version (v2.08k) of the code HFODD which solves the nuclear Skyrme-Hartree-Fock or Skyrme-Hartree-Fock-Bogolyubov problem by using the Cartesian deformed harmonic-oscillator basis. Similarly as in the previous version (v2.08i), all symmetries can be broken, which allows for calculations with angular frequency and angular momentum tilted with respect to the mass distribution. In the new version, three minor errors have been corrected. New Version Program SummaryTitle of program: HFODD; version: 2.08k Catalogue number: ADVA Catalogue number of previous version: ADTO (Comput. Phys. Comm. 158 (2004) 158) Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADVA Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Does the new version supersede the previous one: yes Computers on which this or another recent version has been tested: SG Power Challenge L, Pentium-II, Pentium-III, AMD-Athlon Operating systems under which the program has been tested: UNIX, LINUX, Windows-2000 Programming language used: Fortran Memory required to execute with typical data: 10M words No. of bits in a word: 64 No. of lines in distributed program, including test data, etc.: 52 631 No. of bytes in distributed program, including test data, etc.: 266 885 Distribution format:tar.gz Nature of physical problem: The nuclear mean-field and an analysis of its symmetries in realistic cases are the main ingredients of a description of nuclear states. Within the Local Density Approximation, or for a zero-range velocity-dependent Skyrme interaction, the nuclear mean-field is local and velocity dependent. The locality allows for an effective and fast solution of the self-consistent Hartree-Fock equations, even for heavy nuclei, and for various nucleonic ( n-particle n-hole) configurations, deformations, excitation energies, or angular momenta. Similar Local Density Approximation in the particle-particle channel, which is equivalent to using a zero

  7. Measurement of isotopic cross sections of the fission fragments produced in 500 AMeV {sup 208}Pb + p reaction; Etude de la production des fragments de fission issus de la reaction {sup 208}Pb + p a 500 AMeV

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Dominguez, B

    2003-03-01

    The aim of this work is the study of the fission fragments produced in the spallation reaction {sup 208}Pb + p at 500 AMeV. The fission fragments from Z=23 up to Z=59 have been detected and identified by using the inverse kinematics technique with the high-resolution spectrometer FRS. The production cross sections and the recoil velocities of 430 nuclei have been measured. The measured data have been compared with previous data. The isotopic distributions show a high precision. However, the absolute value of the fission cross section is higher than expected. From the experimental data the characteristics of the average fissioning system have been reconstructed (Z{sub fis}, A{sub fis}, E*{sub fis}). In addition, the number of post-fission neutrons emitted from the fission fragments, v{sub post}, has been determined by using a new method. The experimental data have been compared to the two-steps models describing the spallation reaction. The impact of the model parameters on the observables has been analysed and the reasons Leading to the observed differences between the codes are also presented. This analyse shows a good agreement with the INCL4+ABLA code. (author)

  8. Recovery of radiogenic lead-208 from a residue of thorium and rare earths obtained during the operation of a thorium purification pilot plant; Separacao e recuperacao de chumbo-208 dos residuos de torio terras raras gerados na unidade piloto de purificacao de nitrato de torio

    Energy Technology Data Exchange (ETDEWEB)

    Seneda, Jose Antonio

    2006-07-01

    Brazil has a long tradition in thorium technology, from mineral dressing (monazite) to the nuclear grade thorium compounds. The estimate reserves are 1200,000. ton of ThO{sub 2}. As a consequence from the work of thorium purification pilot plant at Instituto de Pesquisas Energeticas e Nucleares-CNEN/IPEN-SP, about 25 ton of a sludge containing thorium and rare earths was accumulated. It comes as a raffinate and washing solutions from thorium solvent extraction. This sludge, a crude hydroxide named RETOTER contains thorium, rare earths and minor impurities including the radiogenic lead-208, with abundance 88.34 %. This work discusses the results of the studies and main parameters for its recovery by anionic ion exchange technique in the hydrochloric system. The isotope abundance of this lead was analyzed by high resolution mass spectrometer (ICPMS) and thermoionic mass spectrometer (TIMS) and the data was used to calculate the thermal neutron capture cross section. The value of {sigma}{gamma}{sup 0} = 14.6{+-}0.7 mb was found, quite different from the {sigma}{gamma}{sup 0} = 174.2 {+-} 7.0 mb measure cross section for the natural lead. Preliminary study for the thorium and rare earths separation and recovery was discussed as well. (author)

  9. 机用ProTaper镍钛器械治疗1208例患牙的临床体会%Root canal treatment by ProTaper nickel-titanium rotary instruments in 1 208 cases

    Institute of Scientific and Technical Information of China (English)

    谢素娟; 徐芳

    2012-01-01

    目的:观察使用机用ProTaper镍钛器械进行根管治疗的疗效.方法:收集作者2007-07~2009-07使用ProTaper镍钛器械做根管治疗的1 208例患牙,进行术后X线观察及疗效分析.结果:1 208例患牙中,862例牙髓病变治疗成功率98%,346例根尖周病患者治疗成功率93.3%.结论:机用ProTaper镍钛器械预备根管省时、省力,并能较好的保持根管原有形态,大大减少了根管治疗术后并发症,在根管治疗上有较明显优势.%Objective: To observe the effects of ProTaper nickel-titanium rotary instruments in dental root canal therapy. Methods: Root canal therapy was conducted in 1 208 cases during 2007. 07 - 2009. 07 by ProTaper nickel-titanium rotary instruments, The effects were evaluated by clinical observation and postoperative X-ray examination. Results: In the 1208 cases, 862 cases (98% ) with pulp disease and 346 cases(93.3%) with periapical disease were treated successfully. Conclusion; ProTaper nickel-titanium rotary instruments were effective in dental canal therapy.

  10. Study of tracking detector of NEMO3 experiment - simulation of the measurement of the ultra low {sup 208}Tl radioactivity in the source foils used as neutrinoless double beta decay emitters in NEMO3 experiment; Etude du detecteur de traces de l'experience NEMO3. Simulation de la mesure de l'ultra-faible radioactivite en {sup 208}Tl des sources de l'experience NEMO3 candidates a la double desintegration {beta} sans emission de neutrino

    Energy Technology Data Exchange (ETDEWEB)

    Errahmane, K

    2001-04-01

    The purpose of NEMO3 experiment is the research of the neutrinoless double beta decay. This low energy process can sign the massive and Majorana nature of neutrino. This experiment, with a very low radioactive background and containing 10 kg of enriched isotopes, studies mainly {sup 100}Mo. Installed at the Frejus underground laboratory, NEMO3 is a cylindrical detector, which consists in very thin central source foils, in a tracking detector made up of vertical drift cells operating in Geiger mode, in a calorimeter and in a suitable shielding. This thesis is divided in two different parts. The first part is a full study of the features of the tracking detector. With a prototype composed of 9 drift cells, we characterised the longitudinal and transverse reconstruction of position of the ionisation created by a LASER. With the first 3 modules under operation, we used radioactive external neutron sources to measure the transverse resolution of ionisation position in a drift cell for high energy electrons. To study the vertex reconstruction on the source foil, sources of {sup 207}Bi, which produced conversion electrons, were used inside the 3 modules. The second part of this thesis, we show, with simulations, that we can measure, with NEMO3 detector itself, the ultra low level of contamination in {sup 208}Tl of the source foil, which comes from the natural radioactive chain of thorium. Using electron-photons channels, we can obtain the {sup 208}Tl activity in the sources. With an analysis on the energy and on the time of flight of particles, NEMO3 is able to reach a sensitivity of 20{mu}Bq/kg after only 2 months of measurement. This sensitivity is the maximum {sup 208}Tl activity, which we accepted for the sources in the NEMO3 proposal. (author)

  11. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  12. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  13. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  14. The release of dissolved actinium to the ocean: A global comparison of different end-members

    Science.gov (United States)

    Geibert, W.; Charette, M.; Kim, G.; Moore, W.S.; Street, J.; Young, M.; Paytan, A.

    2008-01-01

    The measurement of short-lived 223Ra often involves a second measurement for supported activities, which represents 227Ac in the sample. Here we exploit this fact, presenting a set of 284 values on the oceanic distribution of 227Ac, which was collected when analyzing water samples for short-lived radium isotopes by the radium delayed coincidence counting system. The present work compiles 227Ac data from coastal regions all over the northern hemisphere, including values from ground water, from estuaries and lagoons, and from marine end-members. Deep-sea samples from a continental slope off Puerto Rico and from an active vent site near Hawaii complete the overview of 227Ac near its potential sources. The average 227Ac activities of nearshore marine end-members range from 0.4??dpm m- 3 at the Gulf of Mexico to 3.0??dpm m- 3 in the coastal waters of the Korean Strait. In analogy to 228Ra, we find the extension of adjacent shelf regions to play a substantial role for 227Ac activities, although less pronounced than for radium, due to its weaker shelf source. Based on previously published values, we calculate an open ocean 227Ac inventory of 1.35 * 1018??dpm 227Acex in the ocean, which corresponds to 37??moles, or 8.4??kg. This implies a flux of 127??dpm m-2 y- 1 from the deep-sea floor. For the shelf regions, we obtain a global inventory of 227Ac of 4.5 * 1015??dpm, which cannot be converted directly into a flux value, as the regional loss term of 227Ac to the open ocean would have to be included. Ac has so far been considered to behave similarly to Ra in the marine environment, with the exception of a strong Ac source in the deep-sea due to 231Paex. Here, we present evidence of geochemical differences between Ac, which is retained in a warm vent system, and Ra, which is readily released [Moore, W.S., Ussler, W. and Paull, C.K., 2008-this issue. Short-lived radium isotopes in the Hawaiian margin: Evidence for large fluid fluxes through the Puna Ridge. Marine Chemistry]. Another potential mechanism of producing deviations in 227Ac/228Ra and daughter isotope ratios from the expected production value of lithogenic material is observed at reducing environments, where enrichment in uranium may occur. The presented data here may serve as a reference for including 227Ac in circulation models, and the overview provides values for some end-members that contribute to the global Ac distribution. ?? 2007 Elsevier B.V. All rights reserved.

  15. Experimental Cross Sections for Reactions of Heavy Ions and 208Pb, 209Bi, 238U, and 248Cm Targets

    Energy Technology Data Exchange (ETDEWEB)

    Patin, Joshua Barnes [Univ. of California, Berkeley, CA (United States)

    2002-01-01

    The study of the reactions between heavy ions and 208Pb, 209Bi, 238U, and 248Cm Cm targets was performed to look at the differences between the cross sections of hot and cold fusion reactions. Experimental cross sections were compared with predictions from statistical computer codes to evaluate the effectiveness of the computer code in predicting production cross sections. Hot fusion reactions were studied with the MG system, catcher foil techniques and the Berkeley Gas-filled Separator (BGS). 3n- and 4n-exit channel production cross sections were obtained for the 238U(18O,xn)256-xFm, 238U(22Ne,xn)260-xNo, and 248Cm(15N,xn)263-xLr reactions and are similar to previous experimental results. The experimental cross sections were accurately modeled by the predictions of the HIVAP code using the Reisdorf and Schaedel parameters and are consistent with the existing systematics of 4n exit channel reaction products. Cold fusion reactions were examined using the BGS. The 48Pb(238Ca,xn)256-xNo, 208Pb(50Ti,xn)258-xRf, 208Pb(51V,xn)259-xDb, 50Bi(238Ti,xn)259-xDb, and 209Bi(51V,xn)260-xSg reactions were studied. The experimental production cross sections are in agreement with the results observed in previous experiments. It was necessary to slightly alter the Reisdorf and Schaedel parameters for use in the HIVAP code in order to more accurately model the experimental data. The cold fusion experimental results are in agreement with current 1n- and 2n-exit channel systematics.

  16. Preresidue'' light charged particles from [sup 28]Si+[sup 165]Ho, [sup 16]O+[sup 197]Au, and [sup 16]O+[sup 208]Pb fusion

    Energy Technology Data Exchange (ETDEWEB)

    Fineman, B.J.; Brinkmann, K.; Caraley, A.L.; Gan, N.; McGrath, R.L.; Velkovska, J. (Physics Department, State University of New York at Stony Brook, Stony Brook, New York 11794 (United States))

    1994-10-01

    Proton and [alpha]-particle spectral shapes and multiplicities have been measured in coincidence with evaporation residues from 145 to 220 MeV [sup 28]Si+[sup 165]Ho and 115 and 140 MeV [sup 16]O+[sup 197]Au,[sup 208]Pb fusion reactions. Evaporation residues were separated using an electrostatic deflector and detected with large area surface barrier detectors. Light charged particles were detected at forward and backward angles with 14 single NaI detectors. In the context of the statistical model, the charged particle spectra provide information about the shapes and level densities of the emitting systems. Deformed emitters are inferred, and to a varying degree, an energy-dependent level density parameter is compatible with the data in each of the three cases. Implications for current fusion and fission dynamics studies are discussed.

  17. Solidification structure of C{sub 2.08}Cr{sub 25.43}Si{sub 1.19}Mn{sub 0.43}Fe{sub 70.87} powders fabricated by high pressure gas atomization

    Energy Technology Data Exchange (ETDEWEB)

    Dai Yongxiang; Yang Min; Song Changjiang [Shanghai Key Laboratory of Modern Metallurgy and Materials Processing, Shanghai University, Shanghai (China); Han, Qingyou [Mechanical Engineering Technology Department, Purdue University (United States); Zhai Qijie, E-mail: qjzhai@shu.edu.cn [Shanghai Key Laboratory of Modern Metallurgy and Materials Processing, Shanghai University, Shanghai (China)

    2010-01-15

    Powders of hypoeutectic high chromium white cast iron (C{sub 2.08}Cr{sub 25.43}Si{sub 1.19}Mn{sub 0.43}Fe{sub 70.87}) were produced by high pressure gas atomization. The microstructure of the powders was characterized using light microscopy, scanning electron microscopy and X-ray diffraction. The results showed that the as-atomized powders were mainly composed of austenite and M{sub 7}C{sub 3} (M = Fe, Cr) type carbide, and became ferrite and carbide after annealing. With the decrease of the powder diameter, the number of austenite grains, primary dendrite length and second dendrite arm spacing were decreased. The relationship between cooling rate and microstructure was also determined.

  18. Étude du détecteur de traces de l'expérience NEMO3. Simulation de la mesure de l'ultra-faible radioactivité en ${208}^TL$ des sources de l'expérience NEMO3 candidates à la double désintégration $\\beta$ sans émission de neutrino

    CERN Document Server

    Errahmane, K

    2001-01-01

    Étude du détecteur de traces de l'expérience NEMO3. Simulation de la mesure de l'ultra-faible radioactivité en ${208}^TL$ des sources de l'expérience NEMO3 candidates à la double désintégration $\\beta$ sans émission de neutrino

  19. The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database.

    Science.gov (United States)

    Sasaki, Y F; Sekihashi, K; Izumiyama, F; Nishidate, E; Saga, A; Ishida, K; Tsuda, S

    2000-11-01

    The comet assay is a microgel electrophoresis technique for detecting DNA damage at the level of the single cell. When this technique is applied to detect genotoxicity in experimental animals, the most important advantage is that DNA lesions can be measured in any organ, regardless of the extent of mitotic activity. The purpose of this article is to summarize the in vivo genotoxicity in eight organs of the mouse of 208 chemicals selected from International Agency for Research on Cancer (IARC) Groups 1, 2A, 2B, 3, and 4, and from the U.S. National Toxicology Program (NTP) Carcinogenicity Database, and to discuss the utility of the comet assay in genetic toxicology. Alkylating agents, amides, aromatic amines, azo compounds, cyclic nitro compounds, hydrazines, halides having reactive halogens, and polycyclic aromatic hydrocarbons were chemicals showing high positive effects in this assay. The responses detected reflected the ability of this assay to detect the fragmentation of DNA molecules produced by DNA single strand breaks induced chemically and those derived from alkali-labile sites developed from alkylated bases and bulky base adducts. The mouse or rat organs exhibiting increased levels of DNA damage were not necessarily the target organs for carcinogenicity. It was rare, in contrast, for the target organs not to show DNA damage. Therefore, organ-specific genotoxicity was necessary but not sufficient for the prediction of organ-specific carcinogenicity. It would be expected that DNA crosslinkers would be difficult to detect by this assay, because of the resulting inhibition of DNA unwinding. The proportion of 10 DNA crosslinkers that was positive, however, was high in the gastrointestinal mucosa, stomach, and colon, but less than 50% in the liver and lung. It was interesting that the genotoxicity of DNA crosslinkers could be detected in the gastrointestinal organs even though the agents were administered intraperitoneally. Chemical carcinogens can be classified

  20. Multi-step processes in the (d, t) and (d, {sup 3}He) reactions on {sup 116}Sn and {sup 208}Pb targets at E{sub d} = 200 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Langevin-Joliot, H.; Van de Wiele, J.; Guillot, J. [Institut de Physique Nucleaire, IN2P3/CNRS, 91 - Orsay (France); Koning, A.J. [Nuclear Research and Consultancy Group NRG, NL (Netherlands)

    2000-07-01

    The role of multi-step processes in the reactions {sup 116}Sn(d,t), {sup 208}Pb(d,t) and {sup 116}Sn(d,{sup 3}He), previously studied at E{sub d} = 200 MeV at forward angles and for relatively low energy transfers, has been investigated. We have performed for the first time multi-step calculations taking into account systematically collective excitations in the second and higher order step inelastic transitions. A calculation code based on the Feshbach, Kerman and Koonin model has been modified to handle explicitly these collective excitations, most important in the forward angle domain. One step double differential pick-up cross sections were built from finite range distorted wave results spread in energy using known or estimated hole state characteristics. It is shown that two-step cross sections calculated using the above method compare rather well with those deduced via coupled channel calculations for the same collective excitations. The multi-step calculations performed up to 6 steps reproduce reasonably well the {sup 115}Sn, {sup 207}Pb and {sup 115}In experimental spectra measured up to E{sub x}{approx}- 40 MeV and 15 deg. The relative contributions of steps of increasing order to pick-up cross sections at E{sub d} = 200 MeV and 150 MeV are discussed. (authors)

  1. {open_quotes}Pre-residue{close_quotes} light charged particles from {sup 28}Si+{sup 165}Ho and {sup 16}O+{sup 197}Au, {sup 208}Pb fusion

    Energy Technology Data Exchange (ETDEWEB)

    Fineman, B.J.; Brinkmann, K.T.; Caraley, A.L.; Gan, N.; McGrath, R.L.; Velkovska, J.

    1993-10-01

    Proton and alpha particle spectral shapes and multiplicities have been measured in coincidence with evaporation residues from {sup 28}Si+{sup 165}Ho and {sup 16}O + {sup 197}Au, {sup 208}Pb fusion reactions. Our experiments used 145 to 220 MeV {sup 28}Si and 115 and 140 MeV {sup 16}O beams produced with the Stony Brook LINAC. ER`s were separated using an electrostatic deflector and detected with large area surface barrier detectors. Light charged particles were detected at forward and backward angles with fourteen single NaI detectors. In the context of the statistical model, charged particle spectra yield information about emission barriers and compound nucleus equilibrium level densities. These are significant ingredients in calculations determining fission timescales from other observables such as pre-scission neutron multiplicities or fusion-evaporation excitation functions. Results will also be compared to analyses of pre-scission charged particles from similar systems which required barrier reductions to describe measured spectra.

  2. [Comparison of the performances of gas chromatography-quadrupole time of flight mass spectrometry and gas chromatography-tandem mass spectrometry in rapid screening and confirmation of 208 pesticide residues in fruits and vegetables].

    Science.gov (United States)

    Cao, Xinyue; Pang, Guofang; Jin, Linghe; Kang, Jian; Hu, Xueyan; Chang, Qiaoying; Wang, Minglin; Fan, Chunlin

    2015-04-01

    The performances of gas chromatography-tandem mass spectrometry (GC-MS/MS) and gas chromatography quadrupole time of flight mass spectrometry (GC-QTOF/MS) for the determination of 208 pesticide residues in fruit and vegetable samples, including apple, orange, tomato and cucumber, were compared comprehensively. Based on the differences of the two instruments, their respective characteristics and scopes of application in the detection of the pesticide residues were presented, which provided the reference for the analysis of pesticide residues. The performance parameters of the two instruments, such as overall recoveries, precisions, limits of detection, linear ranges, identification points and matrix effects, were evaluated according to a designed experiment. At three spiked levels (5.0, 10.0 and 20.0 µg/kg), the average recoveries for the majority of pesticides (93.0%) ranged from 70% to 120% in the four matrices with relative standard deviations below 20%. The limits of detection for most of the pesticides by GC-MS/MS and GC-Q-TOF/MS were less than 5.0 µg/kg. Compared with GC-QTOF/MS, GC-MS/MS showed relatively lower limits of detection and wider linear ranges, and its performance was more satisfactory in accurate quantitative analysis due to its superior sensitivity. On the other hand, GC-QTOF/MS provided accurate mass measurement, which was proved to be an efficient analytical tool on the rapid screening and confirmation of a large number of pesticides and non-target compounds.

  3. Cloning and expression profiles analysis of a small heat shock protein 20. 8 gene in Actiasselene(Lepidoptera:Saturniidae)%柳蚕小热休克蛋白20.8基因的克隆与表达分析

    Institute of Scientific and Technical Information of China (English)

    钱岑; 王芳; 李胜; 刘朝良

    2015-01-01

    小热休克蛋白(SHSPs)是从细菌到哺乳动物中广泛存在的一类热应急蛋白质,可调控蛋白的折叠和保护有机体免受外界压力。克隆获得了一个柳蚕shsp的开放阅读框(ORF)序列。该基因cDNA序列全长561 bp,编码了一个由186个氨基酸组成的蛋白。预测蛋白分子质量20.8 ku,等电点为5.98,故命名为As-SHSP 20.8。序列分析和进化树构建结果表明, As-shsp20.8与已知的昆虫shsps家族具有很高的同源性,且与家蚕的shsp20.8聚在同一进化分支上。实时荧光定量PCR (RT-qPCR)结果表明, As-shsp20.8在柳蚕的各组织中均有分布,但在脂肪体中表达量最高;且As-shsp20.8可被大肠杆菌和白僵菌诱导高表达,推测其可能参与了柳蚕的免疫反应。同时,利用pET-28a (+)载体对As-shsp 20.8进行了原核表达,并对重组表达蛋白进行了纯化和抗体制备。将为进一步探索As-SHSP 20.8的免疫功能奠定前期基础。%Small heat shock proteins (SHSPs) are a type of heat emergency proteins widely existing from bacteria to mammals. They can regulate the protein folding and protect the organism from external pressure. Here, a shspcDNAs was firstly isolated from Actias selene (Lepidoptera:Saturniidae). It contained 561 nucleotides with a putative open reading frame (ORF) encoding 186 amino acid residues. The predicted molecular weight and isoelectric point (pI) of this SHSP were 20. 8 ku and 5. 98, respectively, so named As-SHSP 20. 8. Amino acid sequence and phylogenetic analysis among A.seleneand other insects represented that these shsps had high homology, and As-shsp 20. 8 existed in one evolutionary branching with Bombyxmori’s. Results of real time quantitative PCR (RT-qPCR) showed that As-shsp20. 8 can be detected in all tissues we selected, and expressed the highest in fat body. In addition, As-shsp 20. 8 can be induced by Escherichiacoliand Beauveriabassiana, which indicated that it may be involved in the immune

  4. Karlheinz Jetter: Leben und Arbeiten mit behinderten und gefährdeten Säuglingen und Kleinkindern. Mit Beiträgen von Franziska Grob, Wolfgang Praschak, Manfred Pretis, Franz Schönberger und Jan Weisser. Neu herausgegeben von Franziska Grob / Wolfgang Praschak / Jan Weisser. Berlin: epubli (acta empirica – nomade zwei) 2013 (208 S.) [Rezension

    OpenAIRE

    Albers, Timm

    2013-01-01

    Rezension von: Karlheinz Jetter: Leben und Arbeiten mit behinderten und gefährdeten Säuglingen und Kleinkindern. Mit Beiträgen von Franziska Grob, Wolfgang Praschak, Manfred Pretis, Franz Schönberger und Jan Weisser. Neu herausgegeben von Franziska Grob / Wolfgang Praschak / Jan Weisser. Berlin: epubli (acta empirica – nomade zwei) 2013 (208 S.; ISBN 978-3-8442-4115-0)

  5. Stable (206Pb, 207Pb, 208Pb) and radioactive (210Pb) lead isotopes in 1 year of growth of Sphagnum moss from four ombrotrophic bogs in southern Germany: Geochemical significance and environmental implications

    Science.gov (United States)

    Shotyk, William; Kempter, Heike; Krachler, Michael; Zaccone, Claudio

    2015-08-01

    The surfaces of Sphagnum carpets were marked with plastic mesh and 1 year later the production of plant matter was harvested in four ombrotrophic bogs from two regions of southern Germany: Upper Bavaria (Oberbayern, OB) and the Northern Black Forest (Nordschwarzwald, NBF). Radioactive, 210Pb was determined in solid samples using ultralow background gamma spectrometry while total Pb concentrations and stable isotopes (206Pb, 207Pb, 208Pb) were determined in acid digests using ICP-SMS. Up to 12 samples (40 × 40 cm) were collected per site, and 6-10 sites investigated per bog. The greatest variations within a given sampling site were in the range 212-532 Bq kg-1 for 210Pb activity, whereas 206Pb/207Pb and 208Pb/206Pb varied less than 1%. The median values of all parameters for the sites (6-10 per bog) were not significantly different. The median activities of 210Pb (Bq kg-1) in the mosses collected from the bogs in NBF (HO = 372 ± 56, n = 55; WI = 342 ± 58, n = 93) were slightly less from those in OB (GS = 394 ± 50, n = 55; KL = 425 ± 58, n = 24). However, the mosses in the NBF bogs exhibited much greater productivity (187-202 g m-2 a-1) compared to those of OB (71-91 g m-2 a-1), and this has a profound impact on the accumulation rates of 210Pb (Bq m-2 a-1), with the bogs in the NBF yielding fluxes (HO = 73 ± 30; WI = 65 ± 20) which are twice those of OB (GS = 29 ± 11; KL = 40 ± 13). Using the air concentrations of 210Pb measured at Schauinsland (SIL) in the southern Black Forest and average annual precipitation, the atmospheric fluxes of 210Pb at SIL (340 Bq m-2 a-1) exceeds the corresponding values obtained from the mosses by a factor of five, providing the first quantitative estimate of the net retention efficiency of 210Pb by Sphagnum. When the 210Pb activities of all moss samples are combined (n = 227), a significant decrease with increasing plant production rate is observed; in contrast, total Pb concentrations show the opposite trend. The contrasting

  6. The flow dynamics of an extremely large volume pyroclastic flow, the 2.08-Ma Cerro Galán Ignimbrite, NW Argentina, and comparison with other flow types

    Science.gov (United States)

    Cas, Ray A.F.; Wright, Heather M.; Folkes, Christopher B.; Lesti, Chiara; Porreca, Massimiliano; Giordano, Guido; Viramonte, Jose G.

    2011-01-01

    The 2.08-Ma Cerro Galán Ignimbrite (CGI) represents a >630-km3 dense rock equivalent (VEI 8) eruption from the long-lived Cerro Galán magma system (∼6 Ma). It is a crystal-rich (35–60%), pumice (multiple depositional units, often separated by pyroclastic surge deposits. The CGI preserves a widespread sub-horizontal fabric, defined by aligned elongate pumice and lithic clasts, and minerals (e.g. biotite). A sub-horizontal anisotropy of magnetic susceptibility fabric is defined by minute magnetic minerals in all localities where it has been analysed. The CGI is poor in both vent-derived (‘accessory’) lithics and locally derived lithics from the ground surface (‘accidental’) lithics. Locally derived lithics are small (order to explain the contemporaneous maintenance of high particle concentration, high sedimentation rate at the depositional boundary layer and a high level of mobility, it is also proposed that the flow(s) was continuously supplied at a high mass feeding rate. It is also proposed that internal gas pressure within the flow, directed downwards onto the substrate over which the flow was passing, reduced the friction between the flow and the substrate and also enhanced its mobility. The pervasive sub-horizontal fabric of aligned pumice, lithic and even biotite crystals indicates a consistent horizontal shear force existed during transport and deposition in the basal granular flow, consistent with the existence of a laminar, shearing, granular flow regime during the final stages of transport and deposition.

  7. Evaluation of the effect of TM208 on the activity of five cytochrome P450 enzymes using on-line solid-phase extraction HPLC-DAD: a cocktail approach.

    Science.gov (United States)

    Lin, Wensi; Zhang, Jianmei; Ling, Xiaomei; Yu, Ning; Li, Jing; Yang, Haisong; Li, Runtao; Cui, Jingrong

    2013-04-01

    A rapid, simple, and sensitive on-line solid-phase extraction HPLC-DAD method for simultaneous evaluation of the activity of five CYP450 isoforms (CYP1A2, CYP2C19, CYP2D6, CYP2E1 and CYP3A4) in vivo has been developed and validated. The five specific probe substrates include caffeine (1A2), metoprolol (2D6), dapsone (3A4), omeprazole (2C19) and chlorzoxazone (2E1). Automated pre-purification of plasma and enrichment of analytes were performed using a C18 on-line solid-phase extraction cartridge. After being eluted from the cartridge, the analytes and the internal standard antipyrine were separated on a C18 RP analytical column and analyzed by DAD. The method was validated to quantify the concentration ranges of 0.05-50.0 μg/ml for dapsone and omeprazole, 0.1-50.0 μg/ml for caffeine and 0.2-50.0 μg/ml for metoprolol and chlorzoxazone. The linearity (R(2)) for all analytes tested was exceeded 0.99. The intra-day precision ranged from 0.29 to 13% and the inter-day precision ranged from 5.0 to 15%, respectively. The intra-day and inter-day accuracy were between 86.7% and 113.6%. The extraction recoveries were in the range 82.8-109.9% for all the analytes and internal standard antipyrine. This method was successfully applied to evaluate the effects of TM208 on rat five CYP450 isoforms.

  8. Shell model states around $^{208}Pb$

    CERN Document Server

    Liendo, J A; Gómez, R; Caussyn, D D

    2015-01-01

    The experimental binding energies of single-particle and single-hole neutron states belonging to neutron shells that extend from N = 126 to 184 and 82 to 126 respectively, have been reproduced by solving Schr\\"{o}edinger's equation with a potential containing the traditional Woods-Saxon (WS) plus spin-orbit (SO) potential [1-6], and a superficial term proportional to the derivative of a Woods-Saxon like potential. The agreement between theory and experiment has been achieved by varying the strength of the superficial potential for each state studied, until the theoretical binding energy matches the corresponding measured value. Our results indicate the existence of a explicit relationship between the strength of the superficial potential and the orbital angular momentum quantum number $\\ell$ of the state. This dependence has been used to make reasonable predictions for the excitation energy centroids of states located inside and outside the neutron shells investigated. Comparisons are made with results report...

  9. 48 CFR 1552.208-70 - Printing.

    Science.gov (United States)

    2010-10-01

    ...) In compliance with EPA Order 2200.4a, EPA Publication Review Procedure, the Office of Communications, Education, and Media Relations is responsible for the review of materials generated under a contract published or issued by the Agency under a contract intended for release to the public. (c) Affirmative...

  10. 5 CFR 551.208 - Learned professionals.

    Science.gov (United States)

    2010-01-01

    ..., theories, concepts, methods, and techniques; a creative and artistic sense; and an understanding and skill... contracts or other legal documents; drafting, preparing formal comments, or otherwise making substantive... position with a positive educational requirement and requiring the application of accounting theories...

  11. 30 CFR 208.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Petroleum Allocation Act, 15 U.S.C. 751 et seq., except that the time period for determination contained in... other oil on a volume or equivalent value basis. Fair market value means the value of oil—(1) Computed... only be made if substantial amounts of royalty oil are turned back. Refined petroleum product...

  12. 42 CFR 457.208 - Judicial review.

    Science.gov (United States)

    2010-10-01

    ...) The State must file a petition for review with the U.S. Court of Appeals for the circuit in which the... court files a copy of the petition with the Administrator, the Administrator files in the court the record of the proceedings on which the determination was based. (c) Court action. (1) The court is...

  13. 22 CFR 208.905 - Affiliate.

    Science.gov (United States)

    2010-04-01

    .... The ways we use to determine control include, but are not limited to— (a) Interlocking management or... use of employees; or (e) A business entity which has been organized following the exclusion of a person which has the same or similar management, ownership, or principal employees as the excluded person....

  14. 50 CFR 223.208 - Corals.

    Science.gov (United States)

    2010-10-01

    ...) Attempt to do, solicit another to do, or cause to be done, any of the foregoing. (b) Affirmative defense... Protection Act,16 U.S.C. 19jj 16 U.S.C. 668dd-668ee (National Wildlife Refuge System) DOI National Wildlife Refuge System Administration Act,16 U.S.C. 668 FLORIDA: The Board of Trustees of the Internal Improvement...

  15. 8 CFR 208.1 - General.

    Science.gov (United States)

    2010-01-01

    ... International Affairs shall ensure that asylum officers receive special training in international human rights law, nonadversarial interview techniques, and other relevant national and international refugee laws... information on human rights conditions. ...

  16. 31 CFR 208.4 - Waivers.

    Science.gov (United States)

    2010-07-01

    ... compelling urgency that the Government would be seriously injured unless payment is made by a method other than electronic funds transfer; or, where there is only one source for goods or services and the Government would be seriously injured unless payment is made by a method other than electronic funds transfer. ...

  17. 48 CFR 3452.208-70 - Printing.

    Science.gov (United States)

    2010-10-01

    ... less than 5,000 production units of any one page, or less than 25,000 production units in the aggregate of multiple pages, shall not be deemed to be printing. A production unit is defined as one...

  18. 7 CFR 1280.208 - Compensation.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Lamb Promotion, Research, and...

  19. 12 CFR 208.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... checks, or lends money. A branch may include a temporary, seasonal, or mobile facility that meets these... deposits, paying checks, or borrowing money (such as an office established by the bank that...

  20. 24 CFR 880.208 - Financing.

    Science.gov (United States)

    2010-04-01

    ...-backed securities issued by the mortgagee of the Section 8 project, will be subject to 24 CFR part 811... associations, pension funds, insurance companies or other financial institutions; (2) Mortgage insurance programs under the National Housing Act; (3) Mortgage and loan programs of the Farmers' Home Administration...

  1. 24 CFR 881.208 - Financing.

    Science.gov (United States)

    2010-04-01

    ..., the proceeds of the sale of which are to be used to purchase GNMA mortgage-backed securities issued by... loan associations, pension funds, insurance companies or other financial institutions; (2) Mortgage... pledge, or offer as security for any loan or obligation, an Agreement, Contract or ACC entered into...

  2. GPCR Interaction: 208 [GRIPDB[Archive

    Lifescience Database Archive (English)

    Full Text Available Information about hetero oligomer between secretin receptor (SecR) and growth horm...one releasing hormone (GHRH), and interfaces of SecR C Secretin ... SecR C Growth hormone releasing hormone ... GH

  3. 12 CFR 208.77 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... capital levels required to be well capitalized under the capital adequacy regulations or guidelines... Federal Deposit Insurance Act (12 U.S.C. 1813). (c) Capital-related definitions. (1) The terms “Tier 1 capital”, “tangible equity”, “risk-weighted assets” and “total assets” have the meanings given those...

  4. 20.8.Spinal cord disorder

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920190 Significance of DMCT in diagnosisof syringomyelia—an analysis of 19 cases.ZHANG Yanfang (张彦芳),et al.Neurol Dept,1stHosp,Beijing Med Univ.100034.Chin J Neuroland Psychiat 1991; 24 (4): 237-239.We compared and analysed the results of three

  5. 48 CFR 208.7301 - Definitions.

    Science.gov (United States)

    2010-10-01

    ...) means the Defense Logistics Agency field activity located at 700 Robbins Avenue, Philadelphia, PA 19111... responsible for the storage and issue of such material. Refined precious metal means recovered silver, gold...

  6. SNG-log in borehole Ermelund-208

    DEFF Research Database (Denmark)

    Korsbech, Uffe C C

    1996-01-01

    A Spectral Natural Gamma-ray log has been run in a borehole in Ermelunden. The vertical distribution of Th, U, and K is similar to that observed in neighbouring boreholes. A new measuring and data processing technique was used and the probes own background signal was determined. Surprisingly a si......-rays are emitted and detected by the probe. The intensity of cosmic radiation varies with depth, and, therefore, slightly influences the accuracy of the thorium concentration determination.......A Spectral Natural Gamma-ray log has been run in a borehole in Ermelunden. The vertical distribution of Th, U, and K is similar to that observed in neighbouring boreholes. A new measuring and data processing technique was used and the probes own background signal was determined. Surprisingly...

  7. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Directory of Open Access Journals (Sweden)

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  8. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  9. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  10. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  11. 宁夏208例胃癌危险因素的病例对照研究%A Case - Control Study on Risk Factors of Gastric Carcinoma in Ningxia

    Institute of Scientific and Technical Information of China (English)

    高瑞萍; 杨力

    2011-01-01

    目的 探讨宁夏地区胃癌高发的相关危险因素,找出可以干预的一些相关因素.方法 以2008年5月至2008年10月经胃镜检出并经病理确诊的胃癌208例作为研究对象,按1∶2频数匹配原则选取同性别、年龄(相差±5岁)、同一民族、同一居住地的慢性浅表性胃炎416例,进行问卷调查,进行条件Logistic回归分析.结果 多因素条件Logistic回归分析结果显示宁夏地区胃癌发病与幽门螺杆菌感染(OR=4.454,95% CI=2.763 ~7.180)、胃癌家族史(OR=3.574,95% CI=1.909~6.689)、食用腌渍食品(OR=2.485,95% CI=1.574~3.922)和饮井水或窖水(OR=1.914,95% CI=1.216 ~3.014)密切相关.结论 宁夏地区胃癌高发危险因素包括幽门螺杆菌感染、胃癌家族史、经常食用腌渍食品、饮井水或窖水,因此改善饮水条件、防治幽门螺杆菌感染、改变当地居民的生活方式及进行健康宣教对降低胃癌的发生至关重要.%Objective To explore the relationship between personality characteristics and their parental stress in parents of children with autism so as toprovide a theoretical basis for carrying out psychological intervention and support. Methods 34 parents of children with autism and 68 parents of normal children were investigated with Parenting Stress Index Short Form (PSI /SF) and Eysenck Personality Questionnaire (EPQ). Results Parents of children with autism experienced a significantly higher level in the total score of parenting stress and three subscale score (P <0. 001) than their normal counterparts did. In terms of personality, parental distress was significantly negatively correlated with extraversion ( r = -0.500,P=0.003 ) and was significantly positively correlated with neuroticism ( r =0.423 ,P =0.013 ) ; total parenting stress was significantly negatively correlated with extraversion ( r = -0.421,P=0.013) and significantly positively correlated with neuroticism (r =0.434,P =0.010) in parents of children

  12. High frequency (208 GHz) determination of the cubic spin Zeeman term for the U{sup 3+} ion in the dilute magnetic semiconductor crystals of Pb{sub 1−x}U{sub x}Te and Pb{sub 1−x}U{sub x}Se at 5 K by electron paramagnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Misra, Sushil K., E-mail: skmisra@alcor.concordia.ca; Michaels, Adam

    2015-03-15

    A high-frequency (208 GHz) Electron Paramagnetic Resonance (EPR) study on the U{sup 3+} ion (5f{sup 3}, {sup 4}I{sub 9/2}, S=3/2) embedded with 3% concentration in the dilute magnetic semiconductor crystals of PbTe and PbSe, each characterized by cubic symmetry, has been performed at ∼5 K, especially in view to determine the value of the Zeeman cubic spin term parameter u, and the site symmetry of the U{sup 3+} ion (radius 0.089 nm), substituting for the Pb{sup 2+} ion (radius 0.119 nm). The experimental spectra reveal the presence of only one set of EPR lines from U{sup 3+} ions in these host crystals, exhibiting cubic symmetry, whose magnetic axes are oriented along the crystal axes. The spin-Hamiltonian parameters are for both crystals: g=1.9811, u=-0.0257. - Highlights: • EPR studies of U{sup 3+} ion done at 208 GHz at 5 K embedded in PbTe and PbSe crystals. • Site symmetry at U{sup 3+} ion is determined to be cubic from EPR data. • Zeeman cubic spin term parameter u=-0.0257 determined for both crystals. • g=1.9811 Determined for both crystals.

  13. 49 CFR 571.208 - Standard No. 208; Occupant crash protection.

    Science.gov (United States)

    2010-10-01

    ... through S4.2.6.2 of this standard, an inflatable restraint system means an air bag that is activated in a... active and passive restraint systems. S3. Application. (a) This standard applies to passenger cars... cars. S4.1.1Passenger cars manufactured from January 1, 1972, to August 31, 1973. Each passenger car...

  14. ATRAGEREA MINORILOR LA ACTIVITATE CRIMINALĂ SAU DETERMINAREA LOR LA SĂVÂRŞIREA UNOR FAPTE IMORALE (art.208 CP RM vs PRINCIPIUL NEADMITERII TRAGERII LA RĂSPUNDERE PENALĂ DE DOUĂ ORI PENTRU UNA ŞI ACEEAŞI FAPTĂ

    Directory of Open Access Journals (Sweden)

    Stanislav COPEŢCHI

    2016-03-01

    Full Text Available În cadrul studiului întreprins este supusă investigaţiei problema privind stabilirea coraportului între principiul nead­mi­terii tragerii la răspundere penală de două sau mai multe ori pentru una şi aceeaşi faptă şi infracţiunea de atragere a minorilor la activitate criminală sau de determinare a lor la săvârşirea unor fapte imorale. Se ajunge la concluzia că nu se încalcă principiul dreptului penal stipulat la alin.(2 art.7 CP RM atunci când făptuitorul este tras la răspundere penală pentru fapta prevăzută la art.208 CP RM, precum şi pentru instigare la infracţiunea concretă comisă de minor, în ipoteza în care persoana adultă instigă la săvârşirea infracţiunii un minor care este pasibil de a fi supus răspunderii penale şi care de sine stătător comite infracţiunea. ATTRACT MINORS IN CRIMINAL ACTIVITY OR THEIR DETERMINATION TO COMMIT IMMORAL ACTS (art.208 PC RM vs. PRINCIPLE OF AVOINDING CRIMINAL RESPONSABILITY TWICE FOR THE SAME FACTWithin the undertaken study it is being investigated the problem on establishing the correlation between the principle of avoiding criminal responsibility for two or more times for the same act and offence of attract minors in criminal activity or their determination to commit immoral acts. It is concluded that is not violated principle of criminal law stipulated in par.(2 Article 7 PC RM when the offender is held to criminal responsibility for the act stipulated in Article 208 PC RM and for instigation to the concrete offense, committed by minor, in the event that adult person instigate to commit an offence a minor, who is liable to be subjected to criminal liability and that alone commit the offence. 

  15. Residual nuclide formation in 206,207,208,nat-Pb and 209-Bi induced by 0.04-2.6 GeV Protons as well as in 56-Fe induced by 0.3-2.6 GeV Protons

    CERN Document Server

    Titarenko, Yu E; Titarenko, A Yu; Butko, M A; Pavlov, K V; Tikhonov, R S; Florya, S N; Mashnik, S G; Ignatyuk, A V; Gudowski, W

    2007-01-01

    5972 independent and cumulative yields of radioactive residuals nuclei have been measured in 55 thin 206,207,208,nat-Pb and 209-Bi targets irradiated by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6, and 2.6 GeV protons. Besides, 219 yields have been measured in 0.3, 0.5, 0.75, 1.0, 1.5, and 2.6 GeV proton-irradiated 56-Fe target. The protons were extracted from the ITEP U-10 synchrotron. The measured data are compared with experimental results obtained elsewhere and with theoretical calculations by LAHET, MCNPX, CEM03, LAQGSM03, CASCADE, CASCADO, and LAHETO codes. The predictive power was found to be different for each of the codes tested, but was satisfactory on the whole in the case of spallation products. At the same time, none of the codes can de-scribe well the product yields throughout the whole product mass range, and all codes must be further improved.

  16. Contribution to construction and setup of a detection system for the focal plan of the BBS spectrometer. Application to study of the neutron emission decay of the resonant states populated by the reaction ({sup 4}He,{sup 3}He) at 42 MeV/u in nuclei {sup 208}Pb and {sup 209}Pb; Contribution a la construction et a la mise au point d'un systeme de detection pour le plan focal du spectrometre BBS. Application a l'etude de la decroissance par emission de neutrons d'etats resonants peuples par la reaction ({sup 4}He,{sup 3}He) a 42 MeV/u dans les noyaux {sup 208}Pb et {sup 209}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Plankl-Chabib, Elke [Inst. de Physique Nucleaire, Paris-11 Univ., 91 - Orsay (France)

    1999-06-11

    In order to realizean experimental program dedicated to nuclear structure studies we have conceived and constructed at IPN Orsay a detection system for the focal plane of the magnetic spectrometer BBS, installed at the cryogenic cyclotron AGOR of the laboratory KVI (The Netherlands). Two detection units, consisting each of two localization plans of the Cathode Strip Chamber (CSC) type, measure the position and angle of particle trajectory. This information is used for the determination of the reaction parameters at the target by a backtracking procedure. The identification of the reaction products is done by the measurement of their time-of-flight and energy loss. For light ions this task is assumed by plastic scintillators, and for heavy ions by a parallel plan detector (PPAC) and an ionization chamber. This detection system is well adapted to the requirements given by the detection of a large range of ions (protons to {sup 36}Ar at energies of several tenths of MeV/nucleon) as well as the big acceptance, the small dispersion and the aberration of the BBS. The results of the test show the good performances of the detection system. In a first experiment the focal plane detection system was coupled to the neutron multidetector EVEN in order to study the decay of resonant high spin states at high excitation energies by the ({sup 4}He, {sup 3}He) reaction on {sup 207}Pb and {sup 208}Pb targets. The transfer spectra, inclusive and in coincidence, of the nuclei {sup 208}Pb and {sup 209}Pb show a striking resemblance except for an excitation energy shift which is due to the hole in the last neutron shell of {sup 207}Pb. The resonances at l 8 and l = 9 are clearly populated, in agreement with the predictions of the Bonaccorso-Brink model. A sizeable fraction of the decay of the l = 8 resonance is direct, but at excitation energies higher than 15 MeV (in {sup 208}Pb) the decay is mostly statistical.

  17. 12 CFR 208.5 - Dividends and other distributions.

    Science.gov (United States)

    2010-01-01

    ...'s perpetual preferred stock and related surplus, common stock and surplus, and minority interest in... shareholders of each class of stock outstanding. (2) A member bank may not permit any portion of its permanent... the shareholders of each class of stock outstanding. (3) If a member bank has capital surplus...

  18. 24 CFR 570.208 - Criteria for national objectives.

    Science.gov (United States)

    2010-04-01

    ..., illiterate adults, persons living with AIDS, and migrant farm workers; or (B) Require information on family... are low- and moderate-income: abused children, battered spouses, elderly persons, adults meeting...

  19. 22 CFR 208.50 - How is this part written?

    Science.gov (United States)

    2010-04-01

    ... Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION... for the general public and business community to use. The section headings and text, often in the form...” always is the U.S. Agency for International Development. (c) The “Covered Transactions” diagram in...

  20. One-Stop Career Centers. ERIC Digest No. 208.

    Science.gov (United States)

    Imel, Susan

    Since the introduction of one-stop employment systems, many states have attempted to merge traditional employment and training services to provide consolidated programs and easier customer access to services. The Workforce Investment Act (WIA), passed in 1998, requires the formation of locally based one-stop service delivery systems to deliver…

  1. 44 CFR 208.6 - System resource reports.

    Science.gov (United States)

    2010-10-01

    ... request reports from any System resource relating to its activities as part of the System. (b) Reports to... OF HOMELAND SECURITY DISASTER ASSISTANCE NATIONAL URBAN SEARCH AND RESCUE RESPONSE SYSTEM General...

  2. 44 CFR 208.12 - Maximum Pay Rate Table.

    Science.gov (United States)

    2010-10-01

    ... reimbursement and Backfill, for the System Member's actual compensation or the actual compensation of the... OF HOMELAND SECURITY DISASTER ASSISTANCE NATIONAL URBAN SEARCH AND RESCUE RESPONSE SYSTEM General...

  3. Dicty_cDB: SSJ208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CATA sequence update 1998. 1. 7 Translated Amino Acid sequence ---nlgers*dpivasreick...s*kgck*krlfrsy**sy*ilc *i*cnfkiyal*lnffkkkkknxiyis Frame C: ---nlgers*dpivasreickf*VLIPQRVCRCMVHQVLVRHCVLVPL

  4. Electromagnetic Dissociation of Target Nuclei by $^{208}$Pb Projectiles

    CERN Multimedia

    Petridis, A; Wohn, F K

    2002-01-01

    % NA53 \\\\ \\\\ The purpose of this experiment is to study the process of electromagnetic dissociation (ED) that occurs at impact parameters large enough so that there is no nuclear interaction. In these cases strong electromagnetic fields are produced for a short time at the nucleus. For large charges and ultrarelativistic energies, the intense electromagnetic pulse produces cross-sections much larger than the total hadronic cross-section. These effects place significant constraints on the storage times of the heavy ion beams planned for RHIC and LHC.\\\\ \\\\In this experiment we measure the cross-sections for the one- and two-neutron removal processes resulting from the interaction of 160 and 40~GeV/nucleon Pb beams on Au and Co targets. Thin Au targets were bombarded in the beam line of the NA50 experiment. Gamma rays from the residual nuclides produced in the bombardment were measured to determine the saturation activities of $^{196}$Au and $^{195}$Au resulting from ED of the Au target. This along with cross-se...

  5. Dicty_cDB: VHE208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available MX**tilvilvnlldvh sivxtpngtcdnntgnctchnehfgngceftqcplycstpngtcdinsgictcdnehign gceikfieckhkcstkhgicdndsgnckc...ftqcplycstpngtcdinsgictcdnehign gceikfieckhkcstkhgicdndsgnckcdtqtkgltceesrlliesld

  6. 27 CFR 9.208 - Snake River Valley.

    Science.gov (United States)

    2010-04-01

    ... viticultural area is located in Ada, Adams, Boise, Canyon, Elmore, Gem, Gooding, Jerome, Owyhee, Payette, Twin... clockwise rotation on the Vale map, proceeding northerly east of Owyhee Ridge and Long Draw to north of Lake Owyhee, southwesterly and southerly south of Lake Owyhee onto the Mahogany Mountain map,...

  7. 24 CFR 3280.208 - Smoke alarm requirements.

    Science.gov (United States)

    2010-04-01

    ... locations: (i) To protect both the living area and kitchen space. Manufacturers are encouraged to locate the alarm in the living area remote from the kitchen and cooking appliances. A smoke alarm located within 20... when a home is equipped or designed for future installation of a roof-mounted evaporative cooler...

  8. Dicty_cDB: VSC208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available quence update 2000. 9.22 Translated Amino Acid sequence VGRTMVVHADQDDLGKGGKPDSLTTGAAGARLGCGVIGVSQ*isn*nktllnike...fklk*npvkykrstpfl ll Frame B: VGRTMVVHADQDDLGKGGKPDSLTTGAAGARLGCGVIGVSQ*isn*nktllnike

  9. 12 CFR 208.62 - Suspicious activity reports.

    Science.gov (United States)

    2010-01-01

    ... transaction related to a money laundering activity or a violation of the Bank Secrecy Act. This section... or more that involve potential money laundering or violations of the Bank Secrecy Act. Any...

  10. 12 CFR 208.61 - Bank security procedures.

    Science.gov (United States)

    2010-01-01

    ... persons committing crimes against the institution and that will preserve evidence that may aid in their... illuminating, during the hours of darkness, the area around the vault, if the vault is visible from outside the... security officer determines to be appropriate, taking into consideration: the incidence of crimes...

  11. 5 CFR 536.208 - Termination of grade retention.

    Science.gov (United States)

    2010-01-01

    ... grade retention benefits (except that, if an employee's election specifically provides that the... grade retention terminates under this section, the employee's rate of basic pay must be set in... CFR part 531, subpart B, for GS positions). An employee is not entitled to pay retention under subpart...

  12. 12 CFR 208.51 - Real estate lending standards.

    Science.gov (United States)

    2010-01-01

    ... portfolio diversification standards; (ii) Prudent underwriting standards, including loan-to-value limits... portfolio; and (iv) Documentation, approval, and reporting requirements to monitor compliance with the bank...

  13. 19 CFR 351.208 - Suspension of investigation.

    Science.gov (United States)

    2010-04-01

    ... foreign government agree to modify their behavior so as to eliminate dumping or subsidization or the...) Definition of “substantially all.” Under section 704 and section 734 of the Act, exporters that account for... merchandise or a representative consumer organization, as described in section 777(h) of the Act, and...

  14. 12 CFR 208.101 - Obligations concerning institutional customers.

    Science.gov (United States)

    2010-01-01

    ... that the customer is not capable of making independent investment decisions in general. In other cases... independent judgement if the customer's investment decision will be based on its own independent assessment of... decision-making authority to an agent, such as an investment advisor or a bank trust department,...

  15. Dicty_cDB: CHR208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nce. 42 2.9 4 AC154462 |AC154462.2 Mus musculus BAC clone RP24-165F12 from chromosome 14, complete sequence. 42 6.9 2 AL713919 |AL713...919.11 Mouse DNA sequence from clone RP23-41F14 on chrom

  16. Dicty_cDB: AHB208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 312837 tomato root during/after fruit set, Cornell University Lycopersicon esculentum cDNA clone cLEX14G21 5...i aconitase mRNA, partial cds. 58 6e-11 3 AI775579 |AI775579.1 EST256679 tomato resistant, Cornell...1 EST311828 tomato root during/after fruit set, Cornell University Lycopersicon esculentum cDNA clone cLEX10

  17. [Endotracheal tube for laryngeal CO2 laser microsurgery. 208 cases].

    Science.gov (United States)

    Brille, P; Milhaud, A; Starobinsky, E; Postel, J P; Buffet, J P; Vaquette, C; Boudin, G; Daelman, F; Lemoine, E

    1985-07-06

    To suppress the risk inherent in laryngeal microsurgery performed with a CO2 laser beam, the authors suggest to use a reinforced silicone endotracheal tube, the cuff of which is protected by a silicone plus aluminium powder shield. The resistance of silicone to fire is augmented during laser shots by a nitrogen flow on the upper side of the shield at the rates of 2 l/min in patients breathing air and 30 l/min in patients give oxygen.

  18. 44 CFR 208.46 - Title to equipment.

    Science.gov (United States)

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE NATIONAL URBAN SEARCH AND RESCUE RESPONSE SYSTEM Response Cooperative... provided under a DHS Response Cooperative Agreement vests in the Sponsoring Agency, provided that DHS reserves the right to transfer title to the Federal Government or a third party that DHS may name, under...

  19. 8 CFR 208.4 - Filing the application.

    Science.gov (United States)

    2010-01-01

    ... interview, or an immigration judge, in a hearing, shall review the application and give the applicant the... application, the loss of the spousal or parent-child relationship to the principal applicant through marriage... incapacity of the applicant's legal representative or a member of the applicant's immediate family. (6) Safe...

  20. RCT: Module 2.08, Radiological Source Control, Course 8774

    Energy Technology Data Exchange (ETDEWEB)

    Hillmer, Kurt T. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-10

    radioactive source is material used for its emitted radiation. Sources are sealed or unsealed and are classified as accountable or exempt. Radioactive sources are used for response checks, functional checks, and the calibration of instruments and monitors to traceable standards. To ensure the safety and welfare of all personnel, it is important to maintain control of radioactive sources to minimize the potential for the spread of contamination, unnecessary exposure to personnel, loss or theft, and improper disposal. This course will prepare the student with the skills necessary for RCT qualification by passing quizzes, tests, and the RCT Comprehensive Phase 1, Unit 2 Examination (TEST 27566) and will provide in-the-field skills.

  1. 12 CFR 208.84 - What you must disclose.

    Science.gov (United States)

    2010-01-01

    ... mail within 3 business days beginning on the first business day after the sale, excluding Sundays and..., provided you mail it to the consumer within three days beginning the first business day after the... Signatures in Global and National Commerce Act (12 U.S.C. 7001(c)), you may provide the written...

  2. 48 CFR 2452.208-71 - Reproduction of reports.

    Science.gov (United States)

    2010-10-01

    ... Printing and Binding Regulations, printing of reports, data, or other written material, if required herein... one set, size 81/2 by 11 inches or less, printed on one side only and in one color. All copy... for reproduction by photo offset methods) shall become the property of the Government and shall...

  3. 12 CFR 208.42 - Notice of capital category.

    Science.gov (United States)

    2010-01-01

    ... member bank shall be deemed to be within a given capital category for purposes of section 38 of the FDI... Board to the bank of its capital category for purposes of section 38 of the FDI Act and this subpart...

  4. 34 CFR 300.208 - Permissive use of funds.

    Science.gov (United States)

    2010-07-01

    ... a regular class or other education-related setting to a child with a disability in accordance with... accordance with § 300.226. (3) High cost special education and related services. To establish and implement... consortium of which the LEA is a part, to pay for high cost special education and related services. (b...

  5. 40 CFR 59.208 - Charcoal lighter material testing protocol.

    Science.gov (United States)

    2010-07-01

    ... monoxide, carbon dioxide, methane, and non-methane organic carbon are analyzed by the TCA and TCA/Flame... . (WARNING: If the stack is vented into the building enclosure, caution must be taken to avoid carbon... scanning chart recorder, Omega strip recorder with a Strawberry Tree Data Acquisition System, or...

  6. 28 CFR 42.208 - Notice of noncompliance.

    Science.gov (United States)

    2010-07-01

    ... Act (APA) if: (1) The agency gives all interested parties opportunity for— (i) The submission and... consistent with the APA, it shall presume the APA procedures were applied, and send notification under §...

  7. 47 CFR 25.208 - Power flux density limits.

    Science.gov (United States)

    2010-10-01

    ... Region 2, the single-entry equivalent power-flux density, in the space-to-Earth direction, (EPFDdown), at... in Region 1 and 12.2-12.7 GHz in Region 2, the aggregate equivalent power-flux density, in the space... power flux density levels defined below. (1) In the region of the contiguous United States,...

  8. 12 CFR 208.81 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... retail sales practices, solicitations, advertising, or offers of any insurance product or annuity to a... STATE BANKING INSTITUTIONS IN THE FEDERAL RESERVE SYSTEM (REGULATION H) Consumer Protection in Sales of...

  9. 208 External Degree Programme Graduates' Perception of Students ...

    African Journals Online (AJOL)

    Nekky Umera

    1988-03-02

    Mar 2, 1988 ... However, humanities graduates rated learning materials less favourably compared to ... Science, Commerce and Architecture (Young, 1976). Interest in ... accommodation and teaching space (University of Nairobi Students'. Handbook, 1986). .... The study utilized the survey research design. This is a type ...

  10. Dicty_cDB: SFJ208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available _1( AF454831 |pid:none) Apriona germari cathepsin D mRNA, ... 181 2e-90 AB078420_...D-like... 194 3e-97 EF000001_1( EF000001 |pid:none) Fasciola hepatica cathepsin D-like... 188 7e-95 AF454831

  11. Dicty_cDB: SSA208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available l Frames) Frame A: ---dyftthcqsnpvcaq*msykcly*vcvdlsvtflmlpiqinsllpnilqtnvlfk*h ql*qihllalikllhmhsvligvefvks...xqxxkiiwhfqvqf*ifqxkiklnk*lnk linkknkiktfli*k* Translated Amino Acid sequence (Al

  12. Dicty_cDB: SSM208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ore E Sequences producing significant alignments: (bits) Value N CF211492 |CF211492.1 CAB20007_Ia_Ra_H10 Cab...ernet Sauvignon Flower bloom - CAB2 Vitis vinifera cDNA clone CAB20007_Ia_Ra_H10 3', mRNA sequence. 64 1e-15

  13. Centrality dependence of charged-neutral particle fluctuations in 158A (GeVPb)-Pb-208+Pb-208 collisions

    NARCIS (Netherlands)

    Aggarwal, MM; Ahammed, Z; Angelis, ALS; Antonenko, [No Value; Arefiev, [No Value; Astakhov, [No Value; Avdeitchikov, [No Value; Awes, TC; Baba, PVKS; Badyal, SK; Bathe, S; Batiounia, B; Bernier, T; Bhalla, KB; Bhatia, VS; Blume, C; Bucher, D; Busching, H; Carlen, L; Chattopadhyay, S; Decowski, MP; Delagrange, H; Donni, P; Majumdar, MRD; El Chenawi, K; Dubey, AK; Enosawa, K; Fokin, S; Frolov, [No Value; Ganti, MS; Garpman, S; Gavrishchuk, O; Geurts, FJM; Ghosh, TK; Glasow, R; Guskov, B; Gustafsson, H.A.; Gutbrod, HH; Hrivnacova, [No Value; Ippolitov, M; Kalechofsky, H; Karadjev, K; Karpio, K; Kolb, BW; Kosarev, [No Value; Koutcheryaev, [No Value; Kugler, A; Kulinich, P; Kurata, M; Lebedev, A; Lohner, H; Luquin, L; Mahapatra, DP; Manko, [No Value; Martin, M; Martinez, G; Maximov, A; Miake, Y; Mishra, GC; Mohanty, B; Mora, MJ; Morrison, D; Mukhanova, T; Mukhopadhyay, DS; Naef, H; Nandi, BK; Nayak, SK; Nayak, TK; Nianine, A; Nikitine, [No Value; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, P; Nystrand, J; Oskarsson, A; Otterlund, [No Value; Peitzmann, T; Peressounko, D; Petracek, [No Value; Pinganaud, W; Plasil, F; Purschke, ML; Rak, J; Raniwala, R; Raniwala, S; Rao, NK; Retiere, F; Reygers, K; Roland, G; Rosselet, L; Roufanov, [No Value; Roy, C; Rubio, JM; Sambyal, SS; Santo, R; Sato, S; Schlagheck, H; Schutz, Y; Shabratova, G; Shah, TH; Sibiriak, [No Value; Siemiarczuk, T; Silvermyr, D; Sinha, BC; Slavine, N; Soderstrom, K; Sood, G; Sorensen, SP; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A.; Tykarski, L; von der Pijll, EC; von Eijndhoven, N; von Nieuwenhuizen, GJ; Vinogradov, A; Viyogi, YP; Vodopianov, A; Voros, S; Wyslouch, B; Young, GR

    Results on the study of localized fluctuations in the multiplicity of charged particles and photons produced in 158A GeV/c Pb+Pb collisions are presented for varying centralities. The charged versus neutral particle multiplicity correlations in common phase space regions of varying azimuthal sizes

  14. May-July Temperature Variability Since 1801 Inferred from Tree Rings of Pinus tabulaeformis of Helan Mountains in China%树轮记录的贺兰山北部近208年5-7月温度变化

    Institute of Scientific and Technical Information of China (English)

    陈峰; 袁玉江; 魏文寿; 张同文; 张瑞波; 喻树龙; 范子昂; 李杨; 尚华明

    2011-01-01

    reconstructed temperature has 3 warm periods, including 1801-1812, 1940-1953, and 1994-2008. The rising of temperature series in the 2000s is the fastest and indicates that temperature in the 2000s has been warmer than any other period since 1801. The reconstructed temperature during the last 208a has significant period cycles of 120 years (95%), 8. 1 years (95%), 6.5 years (90%), 3.2 years (95%), 2.9 years (95%), and 2. 1 years (99%). Many low density values are forced by volcanic eruptions. Comparison shows volcanic eruptions have no systematic relationship with this reconstruction data, but they are correlated with the regional characteristics of the temperature and forcing data. Detailed analysis, however, suggests a cooling of several years following primarily tropical events with a volcanic eruption index (VEI). Examples include Tambora in Indonesia (1815) , Co-siguina in Nicaragua(1935), Chikurachki in Kurilels(1853), Sheveluch in Kamchatka(1854), Krakatu in Java(1883), Okataina in New Zealand(1886), Santa Maria in Guatemala(1902), Ksudach in Kamchatka (1907), Katmai in Alaska(1912), Bezymianny in Kamchatka (1956), Agung in Indonesia (1963), St Helens in US(1980), El Chichon in Mexico(1982), and Pinatubo in Philippines(199l). The mean of 28 low values after volcanic eruption in reconstructed temperature series is 26. 9℃, which is 0. 5℃ lower than the average over the 1801-2008. The earlywood density of Helan Mountains has good relations with the earlywood densities of Shimen Mountains and Changling Mountains in Gansu.

  15. Coupling of Uranium and Thorium Series Isotope Systematics for Age Determination of Late Pleistocene Zircons using LA-ICP-MS

    Science.gov (United States)

    Sakata, S.; Hirakawa, S.; Iwano, H.; Danhara, T.; Hirata, T.

    2014-12-01

    Zircon U-Th-Pb dating method is one of the most important tools for estimating the duration of magmatism by means of coupling of uranium, actinium and thorium decay series. Using U-Pb dating method, its reliability is principally guaranteed by the concordance between 238U-206Pb and 235U-207Pb ages. In case of dating Quaternary zircons, however, the initial disequilibrium effect on 230Th and 231Pa should be considered. On the other hands, 232Th-208Pb dating method can be a simple but powerful approach for investigating the age of crystallization because of negligible influence from initial disequilibrium effect. We have developed a new correction model for accurate U-Pb dating of the young zircon samples by taking into consideration of initial disequilibrium and a U-Pb vs Th-Pb concordia diagram for reliable age calibration was successfully established. Hence, the U-Th-Pb dating method can be applied to various zircons ranging from Hadean (4,600 Ma) to Quaternary (~50 ka) ages, and this suggests that further detailed information concerning the thermal history of the geological sequences can be made by the coupling of U-Th-Pb, fission track and Ar-Ar ages. In this presentation, we will show an example of U-Th-Pb dating for zircon samples from Sambe Volcano (3 to 100 ka), southwest Japan and the present dating technique using LA-ICP-MS.

  16. Mission SL-4 (AS 208/CM 118/IMU 34)G and N error analysis (Skylab 4)

    Science.gov (United States)

    Helfant, S. B.

    1973-01-01

    Data on the gyro and navigation system performance and operation for the command module are presented. Each reported failure was analyzed with respect to its likelihood of occurence in flight and its impact on the mission.

  17. 42 CFR 412.208 - Puerto Rico rates for Federal fiscal year 1988.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Puerto Rico rates for Federal fiscal year 1988. 412... rates for Federal fiscal year 1988. (a) General rule. CMS determines the Puerto Rico adjusted DRG... Federal fiscal year 1988 for a prospective payment hospital. These rates are determined as described...

  18. Isotopic Trends of Fusion Probability in Reactions with Zn Isotopes Bombarding 208Pb

    Institute of Scientific and Technical Information of China (English)

    LiWenfei; XuHushan; ZuoWei; JiaFei; LiJunqing

    2003-01-01

    where σc is the effective capture cross section for the transition of the colliding nuclei over the entrance Coulomob arrier, Wsur is the survival probability of the compound nucleus. In the DNS model, the compound nucleus is reached by a series of transfers of nuclcons from the light nucleus to the heavy one. Thc dynamics of the DNS is considered as a diffusion process in the mass asymmetry degree of freedom η=(A1 - A2)/(A1 + A2) (A1 and A2 are the mass numbers of the DNS nuclei), PCN is the complete fusion probability, here it is calculated by solving the Master equation numcrically[2]. The fusion barrier Bfus in η supplies a hindrance for fusion.

  19. 33 CFR 208.10 - Local flood protection works; maintenance and operation of structures and facilities.

    Science.gov (United States)

    2010-07-01

    ... underneath the wall. Floating plant or boats will not be allowed to lie against or tie up to the wall. Should... ordinary leakage are functioning properly. Boats or floating plant shall not be allowed to tie up to... of flood waters, the pumping station shall be thoroughly cleaned, pump house sumps flushed,...

  20. 5 CFR 591.208 - How does OPM establish COLA rates?

    Science.gov (United States)

    2010-01-01

    ... differences as indexes. (a) OPM computes price indexes for various categories of consumer expenditures. (b) OPM combines the price indexes using Consumer expenditure weights to produce an overall price index... uses employment weights to combine overall price indexes by survey area for COLA areas. The COLA......

  1. 12 CFR Appendix C to Part 208 - Interagency Guidelines for Real Estate Lending Policies

    Science.gov (United States)

    2010-01-01

    ... or property: • Requirements for feasibility studies and sensitivity and risk analyses (e.g... total of such loans approaches these levels. 2 For the state member banks, the term “total capital... capital loans, where the lender does not rely principally on real estate as security and the extension...

  2. 44 CFR 208.5 - Authority of the Assistant Administrator for the Disaster Operations Directorate.

    Science.gov (United States)

    2010-10-01

    ... Disaster Operations Directorate. (a) Participation in activities of the System. The Assistant Administrator is responsible for determining participation in the System and any activity thereof, including but... FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE NATIONAL URBAN...

  3. 44 CFR 208.9 - Agreements between Sponsoring Agencies and Participating Agencies.

    Science.gov (United States)

    2010-10-01

    .... Every agreement between a Sponsoring Agency and a Participating Agency regarding the System must include... EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE NATIONAL URBAN SEARCH AND...

  4. 44 CFR 208.23 - Allowable costs under Preparedness Cooperative Agreements.

    Science.gov (United States)

    2010-10-01

    ... Members to possess at the time of entry into the System. For instance, DHS will not pay for a medical... EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE NATIONAL URBAN SEARCH AND...

  5. 44 CFR 208.3 - Authority for the National US&R Response System.

    Science.gov (United States)

    2010-10-01

    .... The Federal Emergency Management Agency established and operated the System under the authority of... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE NATIONAL URBAN SEARCH AND RESCUE... agency with responsibility for Emergency Support Function 9, Urban Search and Rescue. ...

  6. Multiple Trait Covariance Association Test Identifies Gene Ontology Categories Associated with Chill Coma Recovery Time in Drosophila melanogaster /631/208/721 /631/208/721 /631/208/729/743 /631/208/729/743 /119 /45 /45/43 article

    DEFF Research Database (Denmark)

    Sørensen, Izel Fourie; Edwards, Stefan M.; Rohde, Palle Duun

    2017-01-01

    features, here defined by gene ontology (GO) terms, enriched for causal variants affecting a quantitative trait in a population with low degree of relatedness. Different set test approaches were compared using simulated data illustrating the impact of trait- and genomic feature-specific factors...

  7. 18 CFR 281.208 - Calculation of essential agricultural requirements and attributable priority 2 entitlements.

    Science.gov (United States)

    2010-04-01

    ... the essential agricultural user has installed capability to use for essential agricultural uses. (2... by the Secretary of Agriculture and calculated in accordance with 7 CFR 2900.4; less (B) Alternative fuel volumes (determined under § 281.304). (ii) Definitions. Current requirements as used in 7 CFR...

  8. 7 CFR 1430.208 - Payment rate and dairy operation payment.

    Science.gov (United States)

    2010-01-01

    ... the months that the Boston Class I milk price under the applicable milk marketing order is equal to or... the feed components of the estimated price of 16 percent Mixed Dairy Feed per pound noted on page 33... be made to dairy operations when the Boston Class I milk price under the applicable Federal milk...

  9. 23 CFR 970.208 - Federal lands pavement management system (PMS).

    Science.gov (United States)

    2010-04-01

    ..., surface type, or other criteria the NPS deems appropriate. (c) The PMS shall be designed to fit the NPS... type, functional classification, and shoulder information; (ii) A history of project dates and types of... long term budget forecasting; and (E) Recommends optimal allocation of limited funds by developing a...

  10. Bis(trimethylphenylammonium hexa[bromido/chlorido(0.792/0.208]stannate(IV

    Directory of Open Access Journals (Sweden)

    Kong Mun Lo

    2010-04-01

    Full Text Available In the title molecular salt, [C6H5(CH33N]2[SnBr4.75Cl1.25], the SnIV atom (site symmetry overline{1} adopts an octahedral coordination geometry. The Br and Cl atoms are disordered over three sites in 0.7415 (13:0.2585 (14, 0.8514 (14:0.1486 (14 and 0.7821 (14:0.2179 (14 ratios.

  11. Surface Erosion of GaN Bombarded by Highly Charged 208Pbq+-Ions

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li-Qing; ZHANG Chong-Hong; YANG Yi-Tao; YAO Cun-Feng; LI Bing-Sheng; JIN Yun-Fan; SUN You-Mei; SONG Shu-Jian

    2008-01-01

    Surface change of gallium nitride specimens after bombardment by highly charged Pbq+-ions (q=25, 35) at room temperature is studied by means of atomic force microscopy. The experimental results reveal that the surface of GaN specimens is significantly etched and erased. An unambiguous step-up is observed. The erosion depth not only strongly depends on the charge state of ions, but also is related to the incident angle of Pbq+ -ions and the ion dose. The erosion depth of the specimens in 60°incidence (tilted incidence) is significantly deeper than that of the normal incidence. The erosion behaviour of specimens has little dependence on the kinetic energy of ion (E,k=360, 700keV). On the other hand, surface roughness of the irradiated area is obviously decreased due to erosion compared with the un-irradiated area. A flat terrace is formed.

  12. 45 CFR 680.20 - Exemptions under 18 U.S.C. 208(b).

    Science.gov (United States)

    2010-10-01

    ... Government: (1) Noncorporate bonds; (2) Shares in a well-diversified money market or mutual fund; (3) Stocks... that amount to: (1) Less than 5 percent of the total portfolio of investments of the owning institution...

  13. 8 CFR 208.15 - Definition of “firm resettlement.”

    Science.gov (United States)

    2010-01-01

    ... the country live; the type of housing, whether permanent or temporary, made available to the refugee; the types and extent of employment available to the refugee; and the extent to which the refugee received permission to hold property and to enjoy other rights and privileges, such as travel documentation...

  14. 8 CFR 208.14 - Approval, denial, referral, or dismissal of application.

    Science.gov (United States)

    2010-01-01

    ... applicant who qualifies as a refugee under section 101(a)(42) of the Act. (b) Approval by an asylum officer... an applicant who qualifies as a refugee under section 101(a)(42) of the Act, and whose identity has... his or her right to an interview or an adjudication by an asylum officer, the asylum officer shall...

  15. 22 CFR 208.760 - How long may my suspension last?

    Science.gov (United States)

    2010-04-01

    ... months. (b) The suspending official may extend the 12 month limit under paragraph (a) of this section for... responsible prosecuting official requests an extension in writing. In no event may a suspension exceed 18 months without initiating proceedings under paragraph (a) of this section. (c) The suspending official...

  16. No. 208-Guidelines for the Management of Herpes Simplex Virus in Pregnancy.

    Science.gov (United States)

    Money, Deborah M; Steben, Marc

    2017-08-01

    To provide recommendations for the management of genital herpes infection in women who want to get pregnant or are pregnant and for the management of genital herpes in pregnancy and strategies to prevent transmission to the infant. More effective management of complications of genital herpes in pregnancy and prevention of transmission of genital herpes from mother to infant. Medline was searched for articles published in French or English related to genital herpes and pregnancy. Additional articles were identified through the references of these articles. All study types and recommendation reports were reviewed. Recommendations were made according to the guidelines developed by the Canadian Task Force on Preventive Health Care. VALIDATION: These guidelines have been reviewed and approved by the Infectious Diseases Committee of the SOGC. The Society of Obstetricians and Gynaecologists of Canada. Copyright © 2017. Published by Elsevier Inc.

  17. 18 CFR 157.208 - Construction, acquisition, operation, replacement, and miscellaneous rearrangement of facilities.

    Science.gov (United States)

    2010-04-01

    ... in column 1 of Table I, under paragraph (d) of this section, or if the project is required to restore... of the certificate holder's system affected by the proposal; (6) The estimated cost and method of... certificate holder shall file in the manner prescribed in §§ 157.6(a) and 385.2011 of this chapter as part...

  18. 37 CFR 41.208 - Content of substantive and responsive motions.

    Science.gov (United States)

    2010-07-01

    ...) Raise a threshold issue, (2) Seek to change the scope of the definition of the interfering subject... to practice in patent cases 11.6, 11.9 B Breach of trust 10.23 Business transactions or relations....10 I Illegal conduct involving moral turpitude 10.23 Illegal fees for services 10.36...

  19. Gene expression studies in cells from primary ciliary dyskinesia patients identify 208 potential ciliary genes

    NARCIS (Netherlands)

    Geremek, Maciej; Bruinenberg, Marcel; Zietkiewicz, Ewa; Pogorzelski, Andrzej; Wijmenga, Cisca; Witt, Michal

    Cilia are small cellular projections that either act as sensors (primary cilia) or propel fluid over the epithelia of various organs (motile cilia). The organellum has gained much attention lately because of its involvement in a group of human diseases called ciliopathies. Primary ciliary dyskinesia

  20. 8 CFR 208.21 - Admission of the asylee's spouse and children.

    Science.gov (United States)

    2010-01-01

    ...-to-join the asylee. The child's mother, if not the principal asylee, shall not be eligible to accompany or follow-to-join the principal asylee unless the child's mother was the principal asylee's spouse... and, in the case of a child, while the child is under 21 years of age and unmarried, provided...