WorldWideScience

Sample records for actinium 207

  1. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  2. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  3. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  4. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Science.gov (United States)

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development.

  5. Relativistic small-core pseudopotentials for actinium, thorium, and protactinium.

    Science.gov (United States)

    Weigand, Anna; Cao, Xiaoyan; Hangele, Tim; Dolg, Michael

    2014-04-03

    Small-core pseudopotentials for actinium, thorium, and protactinium have been energy-adjusted to multiconfiguration Dirac-Hartree-Fock reference data based on the Dirac-Coulomb-Breit Hamiltonian and the Fermi nucleus model. Corresponding optimized valence basis sets of polarized valence quadruple-ζ quality are presented. Atomic test calculations for the first four ionization potentials show satisfactory results at both the Hartree-Fock and the multireference averaged coupled-pair functional level. Highly correlated Fock-space coupled cluster calculations demonstrate that the new pseudopotentials yield ionization potentials, which are in excellent agreement with corresponding all-electron results and experimental data. The pseudopotentials and basis sets supplement a similar set previously published for uranium.

  6. Effects of spin-orbit coupling on actinium under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Rubio-Ponce, A.; Rivera, J. [Departamento de Ciencias Basicas, Universidad Autonoma Metropolitana-Azcapotzalco, Mexico (Mexico); Olguin, D. [Departamento de Fi sica, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico (Mexico)

    2015-04-15

    Actinium (Ac) is a radioactive metal and the first element of the actinide series. At ambient conditions Ac crystallizes in the fcc lattice, however, up to date its phase diagram is unknown. In the present work, we have studied the structural and electronic properties of Ac under hydrostatic pressure assuming the fcc structure as well as three hypothetical structures, namely the hcp, bcc, and sc, and for pressures up to 100 GPa. From our calculations, we found only one structural transition allowed, from the fcc to hcp, our calculated pressure was 39.85 GPa. The calculations were performed by means of the full potential linearized augmented plane wave (FLAPW) method and the generalized gradient approximation (GGA) for the exchange-correlation energy, where we have included in our study the spin-orbit coupling which is important for heavy elements. The total energy results were fitted to the third order Birch-Murnaghan's equation of state. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  7. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  8. At R207

    CERN Multimedia

    1976-01-01

    The photo shows the fast electronics racks of the experiment R207 by the CERN-Holland-Manchester Collaboration. R207 aimed at the study of diffraction dissociation and formation at small momentum transfers. Gerjan Bobbink and Alan Rudge stand in front of the racks.

  9. Report for General Research September 18 to December 11, 1950 (Actinium Volume)

    Energy Technology Data Exchange (ETDEWEB)

    Haring, M.M.

    1951-01-15

    The purpose of the research work presented in this volume is to develop a process for the separation and purification of actinium-227 produced by neutron bombardment of radium-226 and to develop methods by which uniform films of actinium metal may be deposited on metallic surfaces. The design work on the cave structure and mechanical equipment used in the actinium separation is proceeding on schedule. As the mechanical design phase is nearing completion the emphasis is being directed toward processing equipment. The process as well as the mechanical equipment has been adapted from the research work of F. T. Hagemann and the Remote Control Group at Argonne National Laboratory. Consequently, one of the first objectives is to become familiary with the chemistry of the process and the operation of the mechanical equipment. Cold runs have been made on the T.T.A. benzene extraction using lanthanum and barium in place of actinium and radium. No difficulty with the operation was observed. The formation of precipitates was one of the difficulties encountered with the process as the precipitates carry radium. It has been found that metals such as nickel cause these precipitates to form and should, therefore, be avoided in the construction of equipment. it was also found that a T.T.A. solution exposed to 0.5 curie of polonium over a period of days develops a precipitate. Some new mechanical features hav eshown promise. The use of copper-coated glassware which will hold together even though the glass is cracked has made it possible to replace custom-built heaters with standard heating mantles. A new graphite, silicone grease mixture appears to hold up in stopcocks handling benzene and, as a result, may eliminate the necessary of entering the cave for regreasing. Tests on the preparation of dense concrete have given results which meet the shielding requirements for the cave. A strippable paint and tape combination has been studied and specified to provide for decontamination of

  10. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  11. At R207

    CERN Multimedia

    1975-01-01

    With R207 the CERN-Holland-Manchester Collaboration studied proton-proton diffraction dissociation at small momentum transfer. This followed, at Intersection 2, the study of correlations associated with high transverse momentum particles by Daresbury-Liverpool-RHEL Collaboration (R205) and of multiplicity and rapidity distributions in diffractive collisions by CERN-Holland-Lancaster-Manchester (R206), and used part of the previous set-up.

  12. At R207

    CERN Multimedia

    1975-01-01

    At the centre, a barrel shaped hodoscope surrounds the beams' crossing point. It was previously used for experiments R205 and R206 which did run in 1974. After their completion in mid 1975 the equipment of R205 was removed, and that of R206 was modified and rearranged to create two small angle spectrometers, one on each side of the intersection, for experiment R207 (diffraction dissociation and formation at small momentum transfer), by the CERN-Holland-Manchester Collaboration. (see also photos 7508109X and 7508113X) Here on the right, Lars Leistam.

  13. Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

    Science.gov (United States)

    Radchenko, V; Engle, J W; Wilson, J J; Maassen, J R; Nortier, F M; Taylor, W A; Birnbaum, E R; Hudston, L A; John, K D; Fassbender, M E

    2015-02-06

    Actinium-225 (t1/2=9.92d) is an α-emitting radionuclide with nuclear properties well-suited for use in targeted alpha therapy (TAT), a powerful treatment method for malignant tumors. Actinium-225 can also be utilized as a generator for (213)Bi (t1/2 45.6 min), which is another valuable candidate for TAT. Actinium-225 can be produced via proton irradiation of thorium metal; however, long-lived (227)Ac (t1/2=21.8a, 99% β(-), 1% α) is co-produced during this process and will impact the quality of the final product. Thus, accurate assays are needed to determine the (225)Ac/(227)Ac ratio, which is dependent on beam energy, irradiation time and target design. Accurate actinium assays, in turn, require efficient separation of actinium isotopes from both the Th matrix and highly radioactive activation by-products, especially radiolanthanides formed from proton-induced fission. In this study, we introduce a novel, selective chromatographic technique for the recovery and purification of actinium isotopes from irradiated Th matrices. A two-step sequence of cation exchange and extraction chromatography was implemented. Radiolanthanides were quantitatively removed from Ac, and no non-Ac radionuclidic impurities were detected in the final Ac fraction. An (225)Ac spike added prior to separation was recovered at ≥ 98%, and Ac decontamination from Th was found to be ≥ 10(6). The purified actinium fraction allowed for highly accurate (227)Ac determination at analytical scales, i.e., at (227)Ac activities of 1-100 kBq (27 nCi to 2.7 μCi). Copyright © 2014 Elsevier B.V. All rights reserved.

  14. 19 CFR 207.105 - Confidentiality.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Confidentiality. 207.105 Section 207.105 Customs... and Committee Proceedings § 207.105 Confidentiality. (a) Protection of proprietary and privileged.... (b) Confidentiality of proceedings. Upon the request of any charged party pursuant to § 207.106 of...

  15. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  16. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Energy Technology Data Exchange (ETDEWEB)

    Raeder, S., E-mail: s.raeder@gsi.de [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Bastin, B. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Block, M. [Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Institut für Kernchemie, Johannes Gutenberg Universität, 55128 Mainz (Germany); Creemers, P. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Ferrer, R. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fléchard, X. [LPC Caen, ENSICAEN, Université de Caen, CNRS/IN2P3, Caen (France); Franchoo, S. [Institute de Physique Nucléaire (IPN) d’Orsay, 91406 Orsay, Cedex (France); Ghys, L. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); SCK-CEN, Belgian Nuclear Research Center, Boeretang 200, 2400 Mol (Belgium); Gaffney, L.P.; Granados, C. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Heinke, R. [Institut für Physik, Johannes Gutenberg Universität, 55128 Mainz (Germany); Hijazi, L. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); and others

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  17. 47 CFR 97.207 - Space station.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Space station. 97.207 Section 97.207... SERVICE Special Operations § 97.207 Space station. (a) Any amateur station may be a space station. A holder of any class operator license may be the control operator of a space station, subject to...

  18. 47 CFR 18.207 - Technical report.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Technical report. 18.207 Section 18.207... Applications and Authorizations § 18.207 Technical report. When required by the Commission a technical report...(s) under which the equipment is or will be marketed. (e) A statement of the rated...

  19. 40 CFR 240.207 - Aesthetics.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Aesthetics. 240.207 Section 240.207 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.207 Aesthetics....

  20. 22 CFR 207.01 - Policy.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Policy. 207.01 Section 207.01 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT INDEMNIFICATION OF EMPLOYEES § 207.01 Policy. (a) A.I.D. may... employees) for any verdict, judgment or other monetary award which is rendered against any such employee...

  1. 5 CFR 630.207 - Travel time.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Travel time. 630.207 Section 630.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS ABSENCE AND LEAVE Definitions and General Provisions for Annual and Sick Leave § 630.207 Travel time. The travel time granted an...

  2. 30 CFR 77.207 - Illumination.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Illumination. 77.207 Section 77.207 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY... Installations § 77.207 Illumination. Illumination sufficient to provide safe working conditions shall...

  3. 19 CFR 207.23 - Prehearing brief.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Prehearing brief. 207.23 Section 207.23 Customs... EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.23 Prehearing brief... days prior to the date of the hearing specified in the notice of scheduling, a prehearing...

  4. 47 CFR 54.207 - Service areas.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Service areas. 54.207 Section 54.207... SERVICE Carriers Eligible for Universal Service Support § 54.207 Service areas. (a) The term service area means a geographic area established by a state commission for the purpose of determining...

  5. 40 CFR 59.207 - Test methods.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Test methods. 59.207 Section 59.207 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Compound Emission Standards for Consumer Products § 59.207 Test methods. Each manufacturer or...

  6. 30 CFR 90.207 - Compliance sampling.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Compliance sampling. 90.207 Section 90.207... MANDATORY HEALTH STANDARDS-COAL MINERS WHO HAVE EVIDENCE OF THE DEVELOPMENT OF PNEUMOCONIOSIS Sampling Procedures § 90.207 Compliance sampling. (a) The operator shall take five valid respirable dust samples...

  7. 49 CFR 393.207 - Suspension systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Suspension systems. 393.207 Section 393.207... NECESSARY FOR SAFE OPERATION Frames, Cab and Body Components, Wheels, Steering, and Suspension Systems § 393.207 Suspension systems. (a) Axles. No axle positioning part shall be cracked, broken, loose or...

  8. 33 CFR 136.207 - Authorized claimants.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Authorized claimants. 136.207 Section 136.207 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.207...

  9. 34 CFR 300.207 - Personnel development.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Personnel development. 300.207 Section 300.207 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... CHILDREN WITH DISABILITIES Local Educational Agency Eligibility § 300.207 Personnel development. The...

  10. 49 CFR 228.207 - Training.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Training. 228.207 Section 228.207 Transportation... TRANSPORTATION HOURS OF SERVICE OF RAILROAD EMPLOYEES Electronic Recordkeeping § 228.207 Training. (a) In general. A railroad, or a contractor or subcontractor to a railroad, shall provide its train...

  11. Dicty_cDB: SLC207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLC207 (Link to dictyBase) - - - - SLC207E (Link to Original site) - - - - - - SLC...207E 637 Show SLC207 Library SL (Link to library) Clone ID SLC207 (Link to dictyBase) At...las ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SL/SLC2-A/SLC...207Q.Seq.d/ Representative seq. ID SLC207E (Link to Original site) R...epresentative DNA sequence >SLC207 (SLC207Q) /CSM/SL/SLC2-A/SLC207Q.Seq.d/ GGTGTACCACAAGTTGAAGTTCCATTTGATGTT

  12. 33 CFR 127.207 - Warning alarms.

    Science.gov (United States)

    2010-07-01

    ...) WATERFRONT FACILITIES WATERFRONT FACILITIES HANDLING LIQUEFIED NATURAL GAS AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Natural Gas Equipment § 127.207 Warning alarms. (a) The...

  13. 40 CFR 86.207-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false 86.207-94 Section 86.207-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty...

  14. 47 CFR 15.207 - Conducted limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Conducted limits. 15.207 Section 15.207... Conducted limits. (a) Except as shown in paragraphs (b) and (c) of this section, for an intentional radiator... to 30 MHz, shall not exceed the limits in the following table, as measured using a 50 μH/50 ohms...

  15. 24 CFR 570.207 - Ineligible activities.

    Science.gov (United States)

    2010-04-01

    ... construction equipment for use as part of a solid waste disposal facility is eligible under § 570.201(c). (ii... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Ineligible activities. 570.207 Section 570.207 Housing and Urban Development Regulations Relating to Housing and Urban Development...

  16. 31 CFR 560.207 - Prohibited investment.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Prohibited investment. 560.207... § 560.207 Prohibited investment. Except as otherwise authorized pursuant to this part, and... investment by a United States person in Iran or in property (including entities) owned or controlled by...

  17. 31 CFR 800.207 - Covered transaction.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Covered transaction. 800.207 Section 800.207 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF..., which could result in control of a U.S. business by a foreign person....

  18. 40 CFR 2.207 - Class determinations.

    Science.gov (United States)

    2010-07-01

    ... Confidentiality of Business Information § 2.207 Class determinations. (a) The General Counsel may make and issue a class determination under this section if he finds that— (1) EPA possesses, or is obtaining, related... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Class determinations. 2.207 Section...

  19. 48 CFR 207.172 - Human research.

    Science.gov (United States)

    2010-10-01

    ... compliance with 32 CFR Part 219, Protection of Human Subjects; and (b) Must have a Human Research Protection... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Human research. 207.172... OF DEFENSE ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Plans 207.172 Human research. Any...

  20. 44 CFR 207.4 - Responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 207.4... HOMELAND SECURITY DISASTER ASSISTANCE MANAGEMENT COSTS § 207.4 Responsibilities. (a) General. This section identifies key responsibilities of FEMA and grantees in carrying out section 324 of the Stafford Act, 42 U.S...

  1. 5 CFR 430.207 - Monitoring performance.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Monitoring performance. 430.207 Section 430.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERFORMANCE MANAGEMENT Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees §...

  2. Dicty_cDB: SSG207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSG207 (Link to dictyBase) ssg207 - - Contig-U15068-1 SSG207E ...(Link to Original site) - - - - - - SSG207E 445 Show SSG207 Library SS (Link to library) Clone ID SSG207 (Li...nk to dictyBase) Atlas ID ssg207 NBRP ID - dictyBase ID - Link to Contig Contig-U15068-1 Original site URL h...ttp://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSG2-A/SSG207Q.Seq.d/ Representative seq. ID SSG20...7E (Link to Original site) Representative DNA sequence >SSG207 (SSG207Q) /CSM/SS/SSG2-A/SSG207Q.Se

  3. 44 CFR 207.2 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... SECURITY DISASTER ASSISTANCE MANAGEMENT COSTS § 207.2 Definitions. Cap means the maximum dollar amount that... section 507 of the Post-Katrina Emergency Management Reform Act of 2006 (Pub. L. 109-295). The term...

  4. 1 CFR 20.7 - Deadline dates.

    Science.gov (United States)

    2010-01-01

    ... Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.7 Deadline dates. The Manual is... Manual. ...

  5. 29 CFR 1603.207 - Intervention.

    Science.gov (United States)

    2010-07-01

    ... STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.207 Intervention. (a) Any person or entity that...

  6. 48 CFR 207.471 - Funding requirements.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF DEFENSE ACQUISITION PLANNING ACQUISITION PLANNING Equipment Lease or Purchase 207.471 Funding requirements. (a) Fund leases in accordance with DoD Financial Management Regulation (FMR) 7000.14-R, Volume 2A, Chapter 1. (b) DoD leases are either capital leases or operating leases. See FMR 7000.14-R, Volume...

  7. 7 CFR 1160.207 - Compensation and reimbursement.

    Science.gov (United States)

    2010-01-01

    ....207 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order National Fluid Milk Processor Promotion Board § 1160.207 Compensation...

  8. 33 CFR 207.370 - Big Fork River, Minn.; logging.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Big Fork River, Minn.; logging. 207.370 Section 207.370 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.370 Big Fork River, Minn.; logging. (a) During the season of navigation, parties engaged in...

  9. 19 CFR 207.5 - Ex parte meetings.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Ex parte meetings. 207.5 Section 207.5 Customs... EXPORTS TO THE UNITED STATES General Provisions § 207.5 Ex parte meetings. There shall be included in the record of each investigation a record of ex parte meetings as required by section 777(a)(3) of the...

  10. 48 CFR 1415.207-71 - Confidentiality of proposal evaluation.

    Science.gov (United States)

    2010-10-01

    ... the Government for evaluation or advice shall be approved in writing by the HCA; (2) Outside... proposal evaluation. 1415.207-71 Section 1415.207-71 Federal Acquisition Regulations System DEPARTMENT OF... Receipt of Proposals and Information 1415.207-71 Confidentiality of proposal evaluation. (a)...

  11. 41 CFR 101-27.207-1 - Agency controls.

    Science.gov (United States)

    2010-07-01

    ...-Management of Shelf-Life Materials § 101-27.207-1 Agency controls. Agencies shall establish the necessary... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Agency controls. 101-27.207-1 Section 101-27.207-1 Public Contracts and Property Management Federal Property Management...

  12. 41 CFR 101-27.207-2 - Inspection.

    Science.gov (United States)

    2010-07-01

    ...-Management of Shelf-Life Materials § 101-27.207-2 Inspection. Type II items remaining in stock immediately... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Inspection. 101-27.207-2 Section 101-27.207-2 Public Contracts and Property Management Federal Property Management Regulations...

  13. 41 CFR 101-27.207 - Control and inspection.

    Science.gov (United States)

    2010-07-01

    ...-Management of Shelf-Life Materials § 101-27.207 Control and inspection. ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Control and inspection. 101-27.207 Section 101-27.207 Public Contracts and Property Management Federal Property Management...

  14. 24 CFR 92.207 - Eligible administrative and planning costs.

    Science.gov (United States)

    2010-04-01

    ... planning costs. 92.207 Section 92.207 Housing and Urban Development Office of the Secretary, Department of... Prohibited Activities § 92.207 Eligible administrative and planning costs. A participating jurisdiction may expend, for payment of reasonable administrative and planning costs of the HOME program and ADDI, an...

  15. 48 CFR 52.207-1 - Notice of Standard Competition.

    Science.gov (United States)

    2010-10-01

    ... Competition. 52.207-1 Section 52.207-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....207-1 Notice of Standard Competition. As prescribed in 7.305(a), insert the following provision: Notice of Standard Competition (MAY 2006) (a) This solicitation is part of a standard competition...

  16. 48 CFR 52.207-2 - Notice of Streamlined Competition.

    Science.gov (United States)

    2010-10-01

    ... Competition. 52.207-2 Section 52.207-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....207-2 Notice of Streamlined Competition. As prescribed in 7.305(b), insert the following provision: Notice of Streamlined Competition (MAY 2006) (a) This solicitation is part of a streamlined...

  17. 49 CFR 1542.207 - Access control systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Access control systems. 1542.207 Section 1542.207..., DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY AIRPORT SECURITY Operations § 1542.207 Access control systems. (a) Secured area. Except as provided in paragraph (b) of this section, the measures...

  18. 10 CFR 207.4 - Confidentiality of energy information.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Confidentiality of energy information. 207.4 Section 207.4 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental Coordination Act of 1974 § 207.4 Confidentiality of energy information....

  19. 21 CFR 207.30 - Updating drug listing information.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Updating drug listing information. 207.30 Section... Procedures for Domestic Drug Establishments § 207.30 Updating drug listing information. (a) After submitting the initial drug listing information, every person who is required to list drugs under § 207.20...

  20. 8 CFR 207.7 - Derivatives of refugees.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Derivatives of refugees. 207.7 Section 207... REFUGEES § 207.7 Derivatives of refugees. (a) Eligibility. A spouse, as defined in section 101(a)(35) of..., shall be granted refugee status if accompanying or following-to-join the principal alien. An...

  1. 33 CFR 207.306 - Missouri River; administration and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Missouri River; administration and navigation. 207.306 Section 207.306 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.306 Missouri River;...

  2. 19 CFR 207.27 - Short life cycle products.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Short life cycle products. 207.27 Section 207.27... SUBSIDIZED EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.27 Short life... scope of the product category into which to classify the short life cycle merchandise identified by the...

  3. 49 CFR 195.207 - Transportation of pipe.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Transportation of pipe. 195.207 Section 195.207... PIPELINE Construction § 195.207 Transportation of pipe. (a) Railroad. In a pipeline operated at a hoop stress of 20 percent or more of SMYS, an operator may not use pipe having an outer diameter to wall...

  4. 49 CFR 1546.207 - Screening of individuals and property.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Screening of individuals and property. 1546.207 Section 1546.207 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY FOREIGN AIR CARRIER SECURITY Operations § 1546.207 Screening...

  5. 5 CFR 295.207 - Restrictions that apply to testimony.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Restrictions that apply to testimony. 295.207 Section 295.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... PROCEEDINGS Requests for Testimony and Production of Documents § 295.207 Restrictions that apply to...

  6. 28 CFR 2.207 - Supervision reports to Commission.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Supervision reports to Commission. 2.207 Section 2.207 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT....207 Supervision reports to Commission. A regular supervision report shall be submitted to...

  7. 42 CFR 50.207 - Sterilization by hysterectomy.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Sterilization by hysterectomy. 50.207 Section 50.207 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects § 50.207...

  8. 27 CFR 46.207 - Articles held in bond.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Articles held in bond. 46.207 Section 46.207 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Tubes Held for Sale on April 1, 2009 Inventories § 46.207 Articles held in bond. If the dealer is...

  9. Resonance capture cross section of 207Pb

    CERN Document Server

    Domingo-Pardo, C; Aerts, G; Alvarez-Pol, H; Alvarez-Velarde, F; Andrzejewski, J; Andriamonje, Samuel A; Assimakopoulos, P A; Audouin, L; Badurek, G; Baumann, P; Becvar, F; Berthoumieux, E; Bisterzo, S; Calviño, F; Cano-Ott, D; Capote, R; Carrapico, C; Chepel, V; Cennini, P; Chiaveri, Enrico; Colonna, N; Cortés, G; Couture, A; Cox, J; Dahlfors, M; David, S; Dillman, I; Dolfini, R; Dridi, W; Durán, I; Eleftheriadis, C; Embid-Segura, M; Ferrant, L; Ferrari, A; Ferreira-Marques, R; Fitzpatrick, L; Frais-Kölbl, H; Fujii, K; Furman, W; Gallino, R; Gonçalves, I; González-Romero, E M; Goverdovski, A; Gramegna, F; Griesmayer, E; Guerrero, C; Gunsing, F; Haas, B; Haight, R; Heil, M; Herrera-Martínez, A; Igashira, M; Isaev, S; Jericha, E; Kadi, Y; Käppeler, F K; Karamanis, D; Karadimos, D; Kerveno, M; Ketlerov, V; Köhler, P; Konovalov, V; Kossionides, E; Krticka, M; Lamboudis, C; Leeb, H; Lindote, A; Lopes, I; Lozano, M; Lukic, S; Marganiec, J; Marrone, S; Mastinu, P; Mengoni, A; Milazzo, P M; Moreau, C; Mosconi, M; Neves, F; Oberhummer, Heinz; Oshima, M; O'Brien, S; Pancin, J; Papachristodoulou, C; Papadopoulos, C; Paradela, C; Patronis, N; Pavlik, A; Pavlopoulos, P; Perrot, L; Plag, R; Plompen, A; Plukis, A; Poch, A; Pretel, C; Quesada, J; Rauscher, T; Reifarth, R; Rosetti, M; Rubbia, Carlo; Rudolf, G; Rullhusen, P; Salgado, J; Sarchiapone, L; Savvidis, I; Stéphan, C; Tagliente, G; Taín, J L; Tassan-Got, L; Tavora, L; Terlizzi, R; Vannini, G; Vaz, P; Ventura, A; Villamarín, D; Vincente6, M C; Vlachoudis, V; Vlastou, R; Voss, F; Walter, S; Wendler, H; Wiescher, M; Wisshak, K

    2006-01-01

    The radiative neutron capture cross section of 207Pb has been measured at the CERN neutron time of flight installation n_TOF using the pulse height weighting technique in the resolved energy region. The measurement has been performed with an optimized setup of two C6D6 scintillation detectors, which allowed us to reduce scattered neutron backgrounds down to a negligible level. Resonance parameters and radiative kernels have been determined for 16 resonances by means of an R-matrix analysis in the neutron energy range from 3 keV to 320 keV. Good agreement with previous measurements was found at low neutron energies, whereas substantial discrepancies appear beyond 45 keV. With the present results, we obtain an s-process contribution of 77(8)% to the solar abundance of 207Pb. This corresponds to an r-process component of 23(8)%, which is important for deriving the U/Th ages of metal poor halo stars.

  10. 10 CFR 611.207 - Small automobile and component manufacturers.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Small automobile and component manufacturers. 611.207... VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.207 Small automobile and component... individuals; and (2) Manufactures automobiles or components of automobiles. (b) Set Aside—Of the amount...

  11. 18 CFR 376.207 - Personnel and fiscal functions.

    Science.gov (United States)

    2010-04-01

    ... functions. 376.207 Section 376.207 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REVISED GENERAL RULES ORGANIZATION, MISSION, AND FUNCTIONS; OPERATIONS... fiscal functions. Subject to modifications or revocation by authority of the Executive Director,...

  12. 15 CFR 280.207 - Answer and demand for hearing.

    Science.gov (United States)

    2010-01-01

    ... this part. (d) English language required. The answer, all other papers, and all documentary evidence... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Answer and demand for hearing. 280.207 Section 280.207 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade...

  13. 21 CFR 207.31 - Additional drug listing information.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Additional drug listing information. 207.31... Procedures for Domestic Drug Establishments § 207.31 Additional drug listing information. (a) In addition to... following information by letter or by Federal Register notice: (1) For a particular prescription drug...

  14. 27 CFR 555.207 - Construction of type 1 magazines.

    Science.gov (United States)

    2010-04-01

    ... magazines. 555.207 Section 555.207 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO... Construction of type 1 magazines. A type 1 magazine is a permanent structure: a building, an igloo or “Army..., theft-resistant, and ventilated. (a) Buildings. All building type magazines are to be constructed...

  15. 8 CFR 207.6 - Control over approved refugee numbers.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Control over approved refugee numbers. 207... ADMISSION OF REFUGEES § 207.6 Control over approved refugee numbers. Current numerical accounting of approved refugees is maintained for each special group designated by the President. As refugee status...

  16. 8 CFR 207.9 - Termination of refugee status.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... district director in whose district the alien is found if the alien was not a refugee within the meaning...

  17. 44 CFR 207.6 - Use of funds.

    Science.gov (United States)

    2010-10-01

    ... SECURITY DISASTER ASSISTANCE MANAGEMENT COSTS § 207.6 Use of funds. (a) The grantee or subgrantee must use management cost funds provided under this part in accordance with § 13.22 of this chapter and only for costs... accordance with § 207.8(f). (b) Indirect costs may not be charged directly to a project or...

  18. 49 CFR 1544.207 - Screening of individuals and property.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Screening of individuals and property. 1544.207 Section 1544.207 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY AIRCRAFT OPERATOR SECURITY: AIR CARRIERS AND COMMERCIAL...

  19. 19 CFR 207.63 - Circulation of draft questionnaires.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

  20. 5 CFR 591.207 - Which areas are COLA areas?

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Which areas are COLA areas? 591.207... ALLOWANCES AND DIFFERENTIALS Cost-of-Living Allowance and Post Differential-Nonforeign Areas Cost-Of-Living Allowances § 591.207 Which areas are COLA areas? OPM has established the following COLA areas: (a) City...

  1. 42 CFR 93.207 - Departmental Appeals Board or DAB.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Departmental Appeals Board or DAB. 93.207 Section 93.207 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH...

  2. 14 CFR 145.207 - Repair station manual.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Repair station manual. 145.207 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.207 Repair station manual. (a) A certificated repair station must prepare and follow a repair station manual acceptable to...

  3. 23 CFR 650.207 - Plans, specifications and estimates.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Plans, specifications and estimates. 650.207 Section 650... § 650.207 Plans, specifications and estimates. (a) Emphasis shall be placed on erosion control in the preparation of plans, specifications and estimates. (b) All reasonable steps shall be taken to insure...

  4. 31 CFR 538.207 - Prohibited performance of contracts.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Prohibited performance of contracts. 538.207 Section 538.207 Money and Finance: Treasury Regulations Relating to Money and Finance... any United States person of any contract, including a financing contract, in support of an industrial...

  5. 5 CFR 532.207 - Time schedule for wage surveys.

    Science.gov (United States)

    2010-01-01

    ... (4) Scheduling relationships with other pay surveys. (e) The Office of Personnel Management may... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Time schedule for wage surveys. 532.207 Section 532.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE...

  6. 5 CFR 1216.207 - Restrictions that apply to testimony.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Restrictions that apply to testimony. 1216.207 Section 1216.207 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND... of the United States (see also 5 CFR 2635.805). (d) The scheduling of an employee's...

  7. 5 CFR 2417.207 - Restrictions that apply to testimony.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Restrictions that apply to testimony. 2417.207 Section 2417.207 Administrative Personnel FEDERAL LABOR RELATIONS AUTHORITY, GENERAL COUNSEL... behalf of the United States (see also 5 CFR 2635.805). (d) The scheduling of an employee's...

  8. 78 FR 40194 - Proposed Information Collection Request of the ETA 207, Nonmonetary Determination Activities...

    Science.gov (United States)

    2013-07-03

    ... Employment and Training Administration Proposed Information Collection Request of the ETA 207, Nonmonetary....Edward@dol.gov . SUPPLEMENTARY INFORMATION: I. Background The ETA 207 Report, Nonmonetary Determination... concerning the proposed extension collection of the ETA 207, Nonmonetary Determinations Activities...

  9. 75 FR 53982 - Proposed Information Collection Request of the ETA 207, Nonmonetary Determination Activities...

    Science.gov (United States)

    2010-09-02

    ... Employment and Training Administration Proposed Information Collection Request of the ETA 207, Nonmonetary... . SUPPLEMENTARY INFORMATION: I. Background: The ETA 207 Report, Nonmonetary Determination Activities, contains... proposed extension collection of the ETA 207, Nonmonetary Determinations Activities Report. Comments...

  10. Partial Photoneutron Cross Sections for 207,208Pb

    Science.gov (United States)

    Kondo, T.; Utsunomiya, H.; Goriely, S.; Iwamoto, C.; Akimune, H.; Yamagata, T.; Toyokawa, H.; Harada, H.; Kitatani, F.; Lui, Y.-W.; Hilaire, S.; Koning, A. J.

    2014-05-01

    Using linearly-polarized laser-Compton scattering γ-rays, partial E1 and M1 photoneutron cross sections along with total cross sections were determined for 207,208Pb at four energies near neutron threshold by measuring anisotropies in photoneutron emission. Separately, total photoneutron cross sections were measured for 207,208Pb with a high-efficiency 4π neutron detector. The partial cross section measurement provides direct evidence for the presence of pygmy dipole resonance (PDR) in 207,208Pb in the vicinity of neutron threshold. The strength of PDR amounts to 0.32%-0.42% of the Thomas-Reiche-Kuhn sum rule. Several μN2 units of B(M1)↑ strength were observed in 207,208Pb just above neutron threshold, which correspond to M1 cross sections less than 10% of the total photoneutron cross sections.

  11. Dust properties of the cometary globule Barnard 207 (LDN 1489)

    Science.gov (United States)

    Togi, Aditya; Witt, Adolf N.; John, Demi St.

    2017-09-01

    Barnard 207 (B207, LDN 1489, LBN 777), also known as the Vulture Head nebula, is a cometary globule in the Taurus-Auriga-Perseus molecular cloud region. B207 is known to host a Class I protostar, IRAS 04016+2610, located at a projected distance of 8400 au from the dense core centre. Using imaging and photometry over a wide wavelength range, from UV to sub-mm, we study the physical properties of B207 and the dust grains contained within. The core density, temperature, and mass are typical of other globules found in the Milky Way interstellar medium (ISM). The increase in the dust albedo with increasing optical wavelengths, along with the detection of coreshine in the near infrared, indicates the presence of larger dust grains in B207. The measured optical, near-, mid- and far-infrared intensities are in agreement with the CMM+AMM and CMM+AMMI dust grain type of The Heterogeneous dust Evolution Model for Interstellar Solids (THEMIS), suggesting mantle formation on the dust grains throughout the globule. We investigate the possibility of turbulence being responsible for diffusing dust grains from the central core to external outer layers of B207. However, in situ formation of large dust grains cannot be excluded. The reduced images (FITS file) in UV and optical bands are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/605/A99

  12. Phenotype abnormality: 207 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 207 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u713i decreased resis...tance in response to organism Plectosphaerella cucumerina ... Plectosphaerella cucumerina ... decreased resistance to ...

  13. 24 CFR 3282.207 - Manufactured home consumer manual requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Manufactured home consumer manual... Inspection and Certification Requirements § 3282.207 Manufactured home consumer manual requirements. (a) The manufacturer shall provide a consumer manual with each manufactured home that enters the first stage...

  14. 8 CFR 207.5 - Waiting lists and priority handling.

    Science.gov (United States)

    2010-01-01

    ... REFUGEES § 207.5 Waiting lists and priority handling. Waiting lists are maintained for each designated refugee group of special humanitarian concern. Each applicant whose application is accepted for filing by... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Waiting lists and priority handling....

  15. 48 CFR 52.207-5 - Option To Purchase Equipment.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Option To Purchase....207-5 Option To Purchase Equipment. As prescribed in 7.404, insert a clause substantially the same as the following: Option To Purchase Equipment (FEB 1995) (a) The Government may purchase the...

  16. 41 CFR 101-39.207 - Reimbursement for services.

    Science.gov (United States)

    2010-07-01

    ... § 101-39.207 Reimbursement for services. (a) GSA Regional Administrators will issue, as appropriate, regional bulletins announcing the GSA vehicle rental rates applicable to their respective regions. (b) The... billed for accidents and incidents as described in § 101-39.406. Agencies may also be charged...

  17. 23 CFR 230.207 - Sources of assistance.

    Science.gov (United States)

    2010-04-01

    ... FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS EXTERNAL PROGRAMS Supportive Services for Minority, Disadvantaged, and Women Business Enterprises § 230.207 Sources of assistance. It is the policy of the FHWA that all potential sources of assistance to minority business enterprises...

  18. 27 CFR 9.207 - Outer Coastal Plain.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Outer Coastal Plain. 9.207... Outer Coastal Plain. (a) Name. The name of the viticultural area described in this section is “Outer Coastal Plain”. For purposes of part 4 of this chapter, “Outer Coastal Plain” is a term of...

  19. 33 CFR 207.270 - Tallahatchie River, Miss., between Batesville and the mouth; logging.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Tallahatchie River, Miss., between Batesville and the mouth; logging. 207.270 Section 207.270 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.270 Tallahatchie River, Miss., between Batesville and...

  20. 31 CFR 515.207 - Entry of vessels engaged in trade with Cuba.

    Science.gov (United States)

    2010-07-01

    ... with Cuba. 515.207 Section 515.207 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Prohibitions § 515.207 Entry of vessels engaged in trade with Cuba. Except as specifically... place in Cuba to engage in the trade of goods or the purchase or provision of services, may enter a...

  1. 48 CFR 915.207-70 - Handling proposals and information during evaluation.

    Science.gov (United States)

    2010-10-01

    ... information during evaluation. 915.207-70 Section 915.207-70 Federal Acquisition Regulations System DEPARTMENT... of Proposals and Information 915.207-70 Handling proposals and information during evaluation. (a... rights in the Government to use or disclose data or information. (f)(1) Normally, evaluations...

  2. 41 CFR 101-27.207-3 - Marking material to show extended shelf life.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Marking material to show extended shelf life. 101-27.207-3 Section 101-27.207-3 Public Contracts and Property Management Federal...-INVENTORY MANAGEMENT 27.2-Management of Shelf-Life Materials § 101-27.207-3 Marking material to show...

  3. 12 CFR 741.207 - Community development revolving loan program for credit unions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Community development revolving loan program for credit unions. 741.207 Section 741.207 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... Unions § 741.207 Community development revolving loan program for credit unions. Any credit union...

  4. 28 CFR 45.3 - Disciplinary proceedings under 18 U.S.C. 207(j).

    Science.gov (United States)

    2010-07-01

    .... 207(j). 45.3 Section 45.3 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) EMPLOYEE RESPONSIBILITIES § 45.3 Disciplinary proceedings under 18 U.S.C. 207(j). (a) Upon a determination by the Assistant... authorized by 18 U.S.C. 207(j), or subjected to other appropriate disciplinary action under that statute....

  5. 33 CFR 207.185 - Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and navigation. 207.185 Section 207.185 Navigation and... § 207.185 Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and...

  6. 33 CFR 207.470 - Sturgeon Bay and Lake Michigan Ship Canal, Wis.; use and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Sturgeon Bay and Lake Michigan Ship Canal, Wis.; use and navigation. 207.470 Section 207.470 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.470 Sturgeon Bay and Lake Michigan Ship Canal, Wis.; use...

  7. 5 CFR 352.207 - Exercise or termination of reemployment rights.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Exercise or termination of reemployment rights. 352.207 Section 352.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... Emergencies § 352.207 Exercise or termination of reemployment rights. (a) Exercise. The time limits for...

  8. 5 CFR 880.207 - Adjustment of accounts after finding of death.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Adjustment of accounts after finding of death. 880.207 Section 880.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL... Procedures § 880.207 Adjustment of accounts after finding of death. After a missing annuitant is...

  9. 49 CFR 238.207 - Link between coupling mechanism and car body.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Link between coupling mechanism and car body. 238.207 Section 238.207 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... Requirements for Tier I Passenger Equipment § 238.207 Link between coupling mechanism and car body....

  10. 23 CFR 636.207 - Is there a limit on short listed firms?

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Is there a limit on short listed firms? 636.207 Section 636.207 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Selection Procedures, Award Criteria § 636.207 Is there a limit on...

  11. Clinical study of FT-207 suppository for head and neck malignancies. Combined use of FT-207 suppository and radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Tomioka, Masashi; Usami, Masami; Sakamoto, Ayako (Mito National Hospital, Ibaraki (Japan))

    1982-08-01

    Futraful suppository 1.5g per day was administered to 33 patients with head and neck malignancies. Among 33 cases which entered into the study, 16 cases were evaluated. Out of 16 evaluable cases, complete responses (CRs) were obtained in 4 cases and partial responses (PRs) in 7 cases. An overall response rate including 4 CRs and 7 PRs was 68.8%. Side effects due to FT-207 suppository were developed in 14 cases out of 33 patients (42.4%) Side effects such as anal pain, anorexia, diarrhea, pigmentation, exanthema and nail change were observed. No severe side effect was encountered.

  12. ESO 207-61: Its Distance and Very Low Luminosity.

    Science.gov (United States)

    Fredrick, L. W.; Ianna, P. A.

    1992-12-01

    A preliminary trigonometric parallax for the very cool star ESO 207--61 places it at a distance of approximately 16 pc, and confirms its suspected low luminosity. From our parallax and published photometry we estimate its visual absolute magnitude to be 19.47, that is about 0.1 mag fainter than LHS 2924. ESO 207-61 (alpha = 7(h) 06(m) , delta = -48deg 56' [1950]) was identified in a faint proper motion star search program by Ruiz, Takamiya, and Roth (ApJ 367, L59, 1991). Its spectrum resembles that of LHS 2924 (M9). Based on the similarity to LHS 2924 they estimated a distance of 15 pc and a visual absolute magnitude of 19.5. The astrometric data is being acquired at Siding Spring Observatory with the 1 meter reflector and GEC 8603 CCD in the I band. This research is supported by the National Science Foundation, Mount Stromlo and Siding Spring Observatories, and the Estate of Leander J. McCormick.

  13. Core excitations across the neutron shell gap in 207Tl

    Directory of Open Access Journals (Sweden)

    E. Wilson

    2015-07-01

    Full Text Available The single closed-neutron-shell, one proton–hole nucleus 207Tl was populated in deep-inelastic collisions of a 208Pb beam with a 208Pb target. The yrast and near-yrast level scheme has been established up to high excitation energy, comprising an octupole phonon state and a large number of core excited states. Based on shell-model calculations, all observed single core excitations were established to arise from the breaking of the N=126 neutron core. While the shell-model calculations correctly predict the ordering of these states, their energies are compressed at high spins. It is concluded that this compression is an intrinsic feature of shell-model calculations using two-body matrix elements developed for the description of two-body states, and that multiple core excitations need to be considered in order to accurately calculate the energy spacings of the predominantly three-quasiparticle states.

  14. 45 CFR 170.207 - Vocabulary standards for representing electronic health information.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Vocabulary standards for representing electronic health information. 170.207 Section 170.207 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION...

  15. 34 CFR 682.207 - Due diligence in disbursing a loan.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Due diligence in disbursing a loan. 682.207 Section 682.207 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM General...

  16. 27 CFR 44.207 - To commercial vessels and aircraft for consumption as supplies.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false To commercial vessels and aircraft for consumption as supplies. 44.207 Section 44.207 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION...

  17. 49 CFR 240.207 - Procedures for making the determination on vision and hearing acuity.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Procedures for making the determination on vision and hearing acuity. 240.207 Section 240.207 Transportation Other Regulations Relating to... making the determination on vision and hearing acuity. (a) Each railroad, prior to initially...

  18. 33 CFR 207.170 - Federal Dam, Oklawaha River, Moss Bluff, Fla.; pool level.

    Science.gov (United States)

    2010-07-01

    ... Bluff, Fla.; pool level. 207.170 Section 207.170 Navigation and Navigable Waters CORPS OF ENGINEERS..., Moss Bluff, Fla.; pool level. (a) The level of the pool shall normally be maintained at elevation 56.5 feet above sea level: Provided, That the level of the pool may be raised to not exceeding 58.5...

  19. 33 CFR 207.60 - Federal Dam, Hudson River, Troy, N.Y.; pool level.

    Science.gov (United States)

    2010-07-01

    ..., N.Y.; pool level. 207.60 Section 207.60 Navigation and Navigable Waters CORPS OF ENGINEERS..., N.Y.; pool level. (a) Whenever the elevation of the pool created by the Federal dam at Troy, N.Y... automatically when the pool level rises to an elevation of +18.5 feet mean sea level, and conform in...

  20. 33 CFR 207.9 - Mystic River, Mass.; dam of Commonwealth of Massachusetts, Metropolitan District Commission.

    Science.gov (United States)

    2010-07-01

    ... Commonwealth of Massachusetts, Metropolitan District Commission. 207.9 Section 207.9 Navigation and Navigable... Mystic River, Mass.; dam of Commonwealth of Massachusetts, Metropolitan District Commission. (a... the locks. Copies may be obtained without charge from the superintendent; the Commonwealth of...

  1. 20 CFR 416.207 - You do not give us permission to contact financial institutions.

    Science.gov (United States)

    2010-04-01

    ... financial institutions. 416.207 Section 416.207 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... institutions. (a) To be eligible for SSI payments you must give us permission to contact any financial institution and request any financial records that financial institution may have about you. You must give...

  2. NMR absolute shielding scale and nuclear magnetic dipole moment of (207)Pb.

    Science.gov (United States)

    Adrjan, Bożena; Makulski, Włodzimierz; Jackowski, Karol; Demissie, Taye B; Ruud, Kenneth; Antušek, Andrej; Jaszuński, Michał

    2016-06-28

    An absolute shielding scale is proposed for (207)Pb nuclear magnetic resonance (NMR) spectroscopy. It is based on ab initio calculations performed on an isolated tetramethyllead Pb(CH3)4 molecule and the assignment of the experimental resonance frequency from the gas-phase NMR spectra of Pb(CH3)4, extrapolated to zero density of the buffer gas to obtain the result for an isolated molecule. The computed (207)Pb shielding constant is 10 790 ppm for the isolated molecule, leading to a shielding of 10799.7 ppm for liquid Pb(CH3)4 which is the accepted reference standard for (207)Pb NMR spectra. The new experimental and theoretical data are used to determine μ((207)Pb), the nuclear magnetic dipole moment of (207)Pb, by applying the standard relationship between NMR frequencies, shielding constants and nuclear moments of two nuclei in the same external magnetic field. Using the gas-phase (207)Pb and (reference) proton results and the theoretical value of the Pb shielding in Pb(CH3)4, we find μ((207)Pb) = 0.59064 μN. The analysis of new experimental and theoretical data obtained for the Pb(2+) ion in water solutions provides similar values of μ((207)Pb), in the range of 0.59000-0.59131 μN.

  3. 49 CFR 375.207 - What items must be in my advertisements?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false What items must be in my advertisements? 375.207... Services to My Customers General Responsibilities § 375.207 What items must be in my advertisements? (a) You and your agents must publish and use only truthful, straightforward, and honest advertisements....

  4. 19 CFR 207.8 - Questionnaires to have the force of subpoenas; subpoena enforcement.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Questionnaires to have the force of subpoenas; subpoena enforcement. 207.8 Section 207.8 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION... Questionnaires to have the force of subpoenas; subpoena enforcement. Any questionnaire issued by the Commission...

  5. 31 CFR 585.207 - Prohibited transportation-related transactions involving the FRY (S&M).

    Science.gov (United States)

    2010-07-01

    ... transactions involving the FRY (S&M). 585.207 Section 585.207 Money and Finance: Treasury Regulations Relating... transactions involving the FRY (S&M). Except as otherwise authorized, the following are prohibited: (a) Any... transportation to or from the FRY (S&M); (b) The provision of transportation to or from the United States by:...

  6. 19 CFR 207.116 - Commission review on its own motion.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Commission review on its own motion. 207.116... and Committee Proceedings § 207.116 Commission review on its own motion. Within forty-five (45) days of the date of service of the initial determination, the Commission on its own initiative shall...

  7. Alpha-Decay of $^{211}Po$ on the 1633 keV $^{207}Pb$ level

    CERN Document Server

    Chumin, V G; Malikov, Sh R; Norseev, Yu V; Samatov, Z K; Fominykh, V I; Cherevatenko, A P; Yurkova, L V

    2000-01-01

    In investigations of gamma-spectrum of ^{211}At and daughter ^{211}Po and ^{207}Bi isotopes a new branch of the alpha-decay on the ^{207}Pb 1633 keV level is discovered. Its intensity is 8.1 cdot 10^{-4} %.

  8. 24 CFR 207.259a - Waiver of title objection; mortgages formerly Commissioner-held.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Waiver of title objection; mortgages formerly Commissioner-held. 207.259a Section 207.259a Housing and Urban Development Regulations... title objection; mortgages formerly Commissioner-held. If the Commissioner sells a mortgage and...

  9. CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma

    Directory of Open Access Journals (Sweden)

    Grzegorz Dyduch

    2017-05-01

    Full Text Available Introduction : Dendritic cells are crucial for cutaneous immune response. Their role in melanoma progression is however a matter of controversy. Material and methods : The number of dendritic cells within epidermis and in peri- and intratumoral location was analyzed using CD207 immunostain in 17 cases of in situ and 25 case of invasive melanoma. Results : Average peritumoral CD207+ cells count was 22.88 for all cases, 17.94 for in situ lesions and 26.24 for invasive cases. Average epidermal CD207+ cells count was 164.47 for all cases, 183.00 for in situ lesions and 150.78 – for invasive cases. In case of invasive melanomas, peritumoral CD207+ cells count was positively correlated with Breslow stage (R = 0.59 mitotic activity within the tumor (R = 0.62. Invasive cases with regression showed higher intratumoral and epidermal CD207+ cells count than the ones without (275.00 vs. 95.32 and 173.20 vs. 148.35 but lower peritumoral CD207+ cells count (17.60 vs. 27.26. Invasive cases with ulceration showed higher intratumoral and peritumoral CD207+ cells count than the ones without ulceration (220.08 vs. 55.67 and 44.17 vs. 9.69. Conclusions : CD207+ cells play a role in both progression and regression of melanoma but their exact role needs further studies.

  10. 9 CFR 113.207 - Encephalomyelitis Vaccine, Eastern, Western, and Venezuelan, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... Venezuelan, Killed Virus, shall be prepared from virus-bearing cell culture fluids. Each serial or subserial... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Encephalomyelitis Vaccine, Eastern, Western, and Venezuelan, Killed Virus. 113.207 Section 113.207 Animals and Animal Products ANIMAL AND...

  11. 33 CFR 207.320 - Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level.

    Science.gov (United States)

    2010-07-01

    ... Locks and Dam, St. Paul and Minneapolis, Minn.; pool level. 207.320 Section 207.320 Navigation and... § 207.320 Mississippi River, Twin City Locks and Dam, St. Paul and Minneapolis, Minn.; pool level. In.... 362-Minn., Ford Motor Co.), this section is prescribed for the control of the pool level created...

  12. 20 CFR 703.207 - Kinds of negotiable securities that may be deposited; conditions of deposit; acceptance of deposits.

    Science.gov (United States)

    2010-04-01

    ... amount fixed by the Office under the regulations in this part shall deposit any negotiable securities... deposited; conditions of deposit; acceptance of deposits. 703.207 Section 703.207 Employees' Benefits... AND RELATED STATUTES INSURANCE REGULATIONS Insurance Carrier Security Deposit Requirements § 703.207...

  13. 33 CFR 207.476 - The Inland Route-lock in Crooked River, Alanson, Mich.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... § 207.476 The Inland Route—lock in Crooked River, Alanson, Mich.; use, administration, and navigation... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false The Inland Route-lock in Crooked River, Alanson, Mich.; use, administration, and navigation. 207.476 Section 207.476 Navigation...

  14. 33 CFR 207.260 - Yazoo Diversion Canal, Vicksburg, Miss., from its mouth at Kleinston Landing to Fisher Street...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Yazoo Diversion Canal, Vicksburg, Miss., from its mouth at Kleinston Landing to Fisher Street; navigation. 207.260 Section 207.260 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.260 Yazoo Diversion...

  15. 23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

    Science.gov (United States)

    2010-04-01

    ... technology transfer work programs? 420.207 Section 420.207 Highways FEDERAL HIGHWAY ADMINISTRATION..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a...

  16. 20 CFR 30.207 - How does a claimant prove a diagnosis of a beryllium disease covered under Part B?

    Science.gov (United States)

    2010-04-01

    ... beryllium disease covered under Part B? 30.207 Section 30.207 Employees' Benefits OFFICE OF WORKERS... Beryllium Illness Under Part B of Eeoicpa § 30.207 How does a claimant prove a diagnosis of a beryllium... employee developed a covered beryllium illness. Proof that the employee developed a covered...

  17. CD207在白癜风发病机制中的作用研究%The role of CD207 in the pathogenesis of vitiligo

    Institute of Scientific and Technical Information of China (English)

    徐武生; 张江安; 于建斌; 刘冬冬; 李税琪; 郑良娟; 王绘霞

    2014-01-01

    目的:观察白癜风皮损中CD207的表达,探讨白癜风的免疫发病机制。方法采用免疫组织化学法检测12例节段型白癜风、25例寻常型白癜风和10例正常皮肤组织中CD207的表达水平,并比较其差异性。结果节段型白癜风组、寻常型白癜风组表皮内CD207表达分别为(61.2±10.9)和(64.3±12.5)个/mm,均高于正常对照组(52.4±10.3)个/mm,差异有统计学意义(P﹤0.05)。节段型白癜风组与寻常型白癜风组相比,CD207表达差异无统计学意义( P﹥0.05)。结论节段型白癜风、寻常型白癜风皮损组织中CD207的表达高于正常对照组,提示其发病机制与朗格汉斯细胞参与的细胞免疫反应有关。%Objective To observe the expression of CD207 in the lesions of vitiligo and the immune pathogenesis of vitiligo. Meth-ods The CD207 expression level was detected by immunohistochemistry in 12 patients with segmental vitiligo,25 patients with vitiligo vulgaris and 10 normal skin tissues,and the results were compared. Re-sults The expression of CD207 in segmental vitiligo group and vitiligo vulgaris group was(61. 2 ± 10. 9) and(64. 3 ± 12. 5)count/mm respectively,(52. 4 ± 10. 3)count/mm in control group. The differences were statistically significant( P﹤0. 05 ). Conclusions The expression of CD207 in the lesions of seg-mental vitiligo and vitiligo vulgaris is higher than that in the normal control group,indicating that the mechanism of vitiligo is associated with the cellular immunity response which langerhans cell was in-volved.

  18. [Immunophenotypes in 207 pediatric patients with ALL and theirs correlation with cytogenetics and clinical features].

    Science.gov (United States)

    Tong, Hai-Xia; Wang, Qiu-Shi; Lu, Chun-Wei; Wang, Hong; Liu, Zhuo-Gang

    2011-06-01

    The objective of this study was to investigate the immunophenotypic subtype profiles of 207 pediatric patients with acute lymphoblastic leukemia (ALL) and its correlation with cytogenetics and clinical features. 207 children with ALL were immunophenotyped by four color flow cytometry using a panel of monoclonal antibodies. 207 patients were enrolled in this study, out of which 146 cases were subjected to karyotype analysis by R-banding technology. The results showed that 11.6% out of 207 children with ALL were identified as T-ALL, 88.4% as B-ALL. Myeloid antigen (MyAg) expression was documented in 42.5% out of 207 cases analyzed and CD13 was the most commonly expressed MyAg (31.4%). No difference was observed in the expression of MyAg between the groups of patients with T-ALL (41.7%) and B-ALL (42.6%). Abnormal karyotypes were detected in 84 out of 146 (57.5%) children. The clinical and biological characteristics of ALL patients between MyAg(+) and MyAg(-) groups showed that higher percentage of patients with high WBC count (> 50 × 10(9)/L) and higher CD34 positivity were found to be correlated with MyAg(+) ALL. It is concluded that immunophenotype analysis is useful for ALL diagnosis and classification, and the immunophenotypes are in relevance to the abnormal cytogenetic changes as well as clinical features in childhood ALL.

  19. 27 CFR 19.207 - Alternate use of distilled spirits plant and volatile fruit-flavor concentrate premises.

    Science.gov (United States)

    2010-04-01

    ... spirits plant and volatile fruit-flavor concentrate premises. 19.207 Section 19.207 Alcohol, Tobacco... use of distilled spirits plant and volatile fruit-flavor concentrate premises. If a proprietor of...-flavor concentrate plant or vice-a-versa, the proprietor must comply with the requirements of §§ 18.39...

  20. 45 CFR 46.207 - Research not otherwise approvable which presents an opportunity to understand, prevent, or...

    Science.gov (United States)

    2010-10-01

    ...: science, medicine, ethics, law) and following opportunity for public review and comment, including a... of pregnant women, fetuses, or neonates. 46.207 Section 46.207 Public Welfare DEPARTMENT OF HEALTH... 45 Public Welfare 1 2010-10-01 2010-10-01 false Research not otherwise approvable which presents...

  1. 33 CFR 207.169 - Oklawaha River, navigation lock and dam at Moss Bluff, Fla.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Oklawaha River, navigation lock and dam at Moss Bluff, Fla.; use, administration, and navigation. 207.169 Section 207.169 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE...

  2. 33 CFR 207.275 - McClellan-Kerr Arkansas River navigation system: use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false McClellan-Kerr Arkansas River navigation system: use, administration, and navigation. 207.275 Section 207.275 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS §...

  3. 33 CFR 207.380 - Red Lake River, Minn.; logging regulations for portion of river above Thief River Falls.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Red Lake River, Minn.; logging regulations for portion of river above Thief River Falls. 207.380 Section 207.380 Navigation and Navigable... Red Lake River, Minn.; logging regulations for portion of river above Thief River Falls. (a)...

  4. 40 CFR 33.207 - Can an entity reapply to EPA for MBE or WBE certification?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Can an entity reapply to EPA for MBE or... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Certification § 33.207 Can an entity reapply to EPA for MBE or WBE certification? An entity which has been denied MBE or WBE certification may reapply for certification at...

  5. Study of 207Tl126 Produced in Deep-Inelastic Reactions

    Directory of Open Access Journals (Sweden)

    Wilson E.

    2014-03-01

    Full Text Available Deep-inelastic collisions of a 208Pb beam on a 208Pb target were performed using the ATLAS accelerator at Argonne National Laboratory. The Gammasphere detector array was used for the detection of prompt and delayed gamma-rays of the reaction products.207Tl is one proton away from the 208Pb doubly-magic nucleus. Its low-energy level structure is dominated by the single proton-hole states πs1/2−1, πd3/2−1 and πh11/2−1. The 11/2− state is isomeric with T1/2 = 1.33(11 s. The reaction partner of 207Tl is 209Bi, which has arelatively well established level scheme compared to 207Tl. Cross-coincidences between these two nuclei were used to confirm or establish levels above the 11/2− isomeric state in 207Tl. These states are obtained via breaking of the neutron core. Angular correlation analysis was performed on known transitions in 208Pb, proving the applicability of this method for multipolarity assignment.

  6. 48 CFR 52.207-3 - Right of First Refusal of Employment.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Right of First Refusal of....207-3 Right of First Refusal of Employment. As prescribed in 7.305(c), insert the following clause: Right of First Refusal of Employment (MAY 2006) (a) The Contractor shall give Government personnel...

  7. 21 CFR 207.25 - Information required in registration and drug listing.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Information required in registration and drug... DISTRIBUTION Procedures for Domestic Drug Establishments § 207.25 Information required in registration and drug...) provides that information required by the act be furnished as follows: (1) A list of drugs, including...

  8. 42 CFR 441.207 - Drugs and devices and termination of ectopic pregnancies.

    Science.gov (United States)

    2010-10-01

    ... APPLICABLE TO SPECIFIC SERVICES Abortions § 441.207 Drugs and devices and termination of ectopic pregnancies... and for medical procedures necessary for the termination of an ectopic pregnancy. ... 42 Public Health 4 2010-10-01 2010-10-01 false Drugs and devices and termination of...

  9. 46 CFR 308.207 - War risk protection and indemnity insurance policy.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false War risk protection and indemnity insurance policy. 308... OPERATIONS WAR RISK INSURANCE War Risk Protection and Indemnity Insurance § 308.207 War risk protection and indemnity insurance policy. The standard form of war risk protection and indemnity insurance policy, Form...

  10. 49 CFR 399.207 - Truck and truck-tractor access requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Truck and truck-tractor access requirements. 399... Vehicles § 399.207 Truck and truck-tractor access requirements. (a) General rule. Any person entering or exiting the cab or accessing the rear portion of a high profile COE truck or truck-tractor shall...

  11. 49 CFR 377.207 - Effect of mailing freight bills or payments.

    Science.gov (United States)

    2010-10-01

    ... Common Carriers, and Household Goods Freight Forwarders § 377.207 Effect of mailing freight bills or payments. (a) Presentation of freight bills by mail. When carriers present freight bills by mail, the time... 49 Transportation 5 2010-10-01 2010-10-01 false Effect of mailing freight bills or payments. 377...

  12. 50 CFR 648.207 - Herring Research Set-Aside (RSA).

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Herring Research Set-Aside (RSA). 648.207... during the interim years and decides to publish a second RFP. Proposals to fund research that would start..., researchers must provide the Council and NMFS with a report of research findings, which must include:...

  13. 13 CFR 105.207 - Politically motivated activities with respect to the Minority Small Business Program.

    Science.gov (United States)

    2010-01-01

    ... Assistance SMALL BUSINESS ADMINISTRATION STANDARDS OF CONDUCT AND EMPLOYEE RESTRICTIONS AND RESPONSIBILITIES Restrictions and Responsibilities Related to Sba Employees and Former Employees § 105.207 Politically motivated... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Politically motivated...

  14. 10 CFR 207.3 - Method of collecting energy information under ESECA.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Method of collecting energy information under ESECA. 207.3... than ESECA or that such energy information should, as a matter of discretion, be collected under the... verifying the accuracy of any energy information requested, acquired, or collected by the DOE,...

  15. 7 CFR 330.207 - Permits for movement of organisms issued by other agencies.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Permits for movement of organisms issued by other...; GENERAL; PLANT PESTS; SOIL, STONE, AND QUARRY PRODUCTS; GARBAGE Movement of Plant Pests § 330.207 Permits for movement of organisms issued by other agencies. Inspectors shall recognize permits for...

  16. 21 CFR 207.35 - Notification of registrant; drug establishment registration number and drug listing number.

    Science.gov (United States)

    2010-04-01

    ... LISTING OF DRUGS IN COMMERCIAL DISTRIBUTION Procedures for Domestic Drug Establishments § 207.35... appear on all drug labels and in other drug labeling, including the label of any prescription drug... prescription drug products). (ii) The NDC number shall be preceded by the prefix “NDC” or “N” when it is...

  17. 40 CFR 61.207 - Radium-226 sampling and measurement procedures.

    Science.gov (United States)

    2010-07-01

    ... for Radon Emissions From Phosphogypsum Stacks § 61.207 Radium-226 sampling and measurement procedures. (a) Before removing phosphogypsum from a stack for distribution in commerce pursuant to § 61.204, or § 61.206, the owner or operator of a phosphogypsum stack shall measure the average...

  18. Core breaking and octupole low-spin states in $^{207}$ Tl

    CERN Multimedia

    We propose to study the low-spin level structure of the $^{207}$Tl nucleus populated by the $\\beta$- decay of $^{207}$Hg. While $^{207}$Tl is a single-proton hole nucleus, the majority of the observed states will have a three-particle structure thus requiring the breaking of the neutron or proton core, or a collective octupole phonon coupled to the single proton hole. Thus information will be obtained on the single particle orbitals in the vicinity of the N=126 and Z=82 magic numbers, and on the size of the shell gap. The results will be used to improve the predictive power of the shell model for more exotic nuclei as we move to lighter N=126 nuclei.The experiment will use the ISOLDE Decay station, and will take advantage of the $^{207}$Hg beam from the molten lead target. A test on the feasibility to produce an $^{208}$Hg beam from the same target, with the aim to study the $\\beta$-decay into $^{208}$Tl, could be performed at the same time.

  19. 42 CFR 438.207 - Assurances of adequate capacity and services.

    Science.gov (United States)

    2010-10-01

    ... HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE Quality Assessment and Performance Improvement Access Standards § 438.207 Assurances of adequate capacity and services. (a) Basic rule. The State... that is sufficient in number, mix, and geographic distribution to meet the needs of the anticipated...

  20. Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters.

    Science.gov (United States)

    Nakano, K; Todo, T; Chijiiwa, K; Tanaka, M

    2001-04-01

    Gallbladder cancer is an extremely difficult disease to cure once metastases occur. In this paper, we explored the potential of G207, an oncolytic, replication-competent herpes simplex virus type 1 mutant, as a new therapeutic means for gallbladder cancer. Gallbladder carcinoma cell lines (four human and one hamster) showed nearly total cell killing within 72 h of G207 infection at a m.o.i. of 0.25 to 2.5 in vitro. The susceptibility to G207 cytopathic activity correlated with the infection efficiency demonstrated by lacZ expression. Intraneoplastic inoculation of G207 (1 x 10(7) pfu) in immunocompetent hamsters bearing established subcutaneous KIGB-5 tumors caused a significant inhibition of tumor growth and prolongation of survival. Repeated inoculations (three times with 4-day intervals) were significantly more efficacious than a single inoculation. In hamsters with bilateral subcutaneous KIGB-5 tumors, inoculation of one tumor alone with G207 caused regression or growth reduction of uninoculated tumors as well as inoculated tumors. In athymic mice, however, the anti-tumor effect was largely reduced in inoculated tumors and completely abolished in remote tumors, suggesting large contribution of T-cell-mediated immune responses to both local and systemic anti-tumor effect of G207. These results indicate that G207 may be useful as a new strategy for gallbladder cancer treatment.

  1. Analisis Film Horor Indonesia Produksi Tahun 2014 (Studi Kasus: Mall Klender dan Kamar 207

    Directory of Open Access Journals (Sweden)

    Dedi Sukatno Sembiring Meliala

    2016-02-01

    Full Text Available Abstrak Film horor erat kaitannya dengan tokoh antagonis yang menimbulkan ketakutan pada penonton dalam bentuk makhluk supranatural seperti hantu, roh jahat dan sebagainya. Karakteristik film dengan genre horor membuat penonton terbawa suasana dengan alur ceritanya yang menakutkan. Namun, beberapa dari film horor Indonesia menyajikan adegan-adegan yang kurang sopan bahkan tergolong asusila atau porno. Untuk itu, penelitian ini ingin melihat apakah terdapat konten pornografi pada film Mall Klender dan Kamar 207 yang merupakan film horor Indonesia terlaris di tahun 2014. Analisis dilakukan dengan melihat pandangan dan penilaian 30 responden dengan karakteristik yaitu penonton film horor Indonesia yang berusia 20-40 tahun. Berdasarkan hasil analisis, tidak didapatkan konten pornografi pada film Mall Klender dan Kamar 207. Adegan-adegan yang terindikasi sebagai konten pornografi ternyata masih dapat diterima oleh penonton sebagai adegan yang berada dalam batas kewajaran dan mendukung pembawaan suasana dan kesan dalam cerita yang disampaikan. Kata Kunci: film horror Indonesia, analisis konten, pornografi Abstract The horror film is closely related to the antagonist that causes fear for audience in the form of supernatural creatures such as ghosts, demons and so on. Characteristic of the horor film is to make the audience carried away with the scary plot. However, some of the existing Indonesian horror film presents scenes that classified as obscene or pornographic. Therefore, this study wanted to see if there are any pornographic content on the film Klender Mall and Room 207 is the best-selling Indonesian horror movie in 2014. The analysis was done by looking at the view and assessment of 30 respondents which are Indonesian horror movie goers aged 20-40 years. Based on the analysis, there is no founding of pornographic content on the film Klender Mall and Room 207. The scenes that indicated as pornographic content was still acceptable by the audience

  2. LOW-METALLICITY YOUNG CLUSTERS IN THE OUTER GALAXY. I. Sh 2-207

    Energy Technology Data Exchange (ETDEWEB)

    Yasui, Chikako [Department of Astronomy, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kobayashi, Naoto; Izumi, Natsuko [Institute of Astronomy, School of Science, University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Tokunaga, Alan T. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Saito, Masao, E-mail: ck.yasui@astron.s.u-tokyo.ac.jp [Nobeyama Radio Observatory, 462-2 Nobeyama, Minamimaki-mura, Minamisaku-gun, Nagano 384-1305 (Japan)

    2016-03-15

    To study star formation in low-metallicity environments ([M/H] ∼ −1 dex), we obtained deep near-infrared (NIR) images of Sh 2-207 (S207), which is an H ii region in the outer Galaxy with a spectroscopically determined metallicity of [O/H] ≃ −0.8 dex. We identified a young cluster in the western region of S207 with a limiting magnitude of K{sub S} = 19.0 mag (10σ) that corresponds to a mass detection limit of ≲0.1 M{sub ⊙} and enables the comparison of star-forming properties under low metallicity with those of the solar neighborhood. From the fitting of the K-band luminosity function (KLF), the age and distance of the S207 cluster are estimated at 2–3 Myr and ∼4 kpc, respectively. The estimated age is consistent with the suggestion of small extinctions of stars in the cluster (A{sub V} ∼ 3 mag) and the non-detection of molecular clouds. The reasonably good fit between the observed KLF and the model KLF suggests that the underlying initial mass function (IMF) of the cluster down to the detection limit is not significantly different from the typical IMFs in the solar metallicity. From the fraction of stars with NIR excesses, a low disk fraction (<10%) in the cluster with a relatively young age is suggested, as we had previously proposed.

  3. 大豆根际促生菌Sneb207对不同种类线虫毒性的研究%Virulence Difference of Plant Growth Promoting Rhizobacteria Sneb207 to Different Nematodes

    Institute of Scientific and Technical Information of China (English)

    孙华; 段玉玺; 陈立杰; 王媛媛

    2009-01-01

    从大豆根瘤中分离到1株根际促生菌Sneb207,经鉴定为巨大芽孢杆菌(Bacillus megaterium).室内测定结果表明:其发酵产物对豆苗生长促生效果显著,发酵液灭菌后仍具有促生活性,具有广泛的应用价值.用该菌发酵液测定了对各种线虫的作用,结果表明毒力作用具有差异,大小顺序分别为大豆胞囊线虫、北方根结线虫、水稻干尖线虫和腐烂茎线虫.不同浓度发酵液对大豆胞囊线虫均有较好的防治作用,与无菌水对照处理有显著差异.说明细菌菌株Sneb207是控制大豆胞囊线虫病且促进大豆生长的有效因子.%Strain Sneb207 was isolated from soybean nodule and identified as Bacillus megaterium. It is proved the fermentation filtrate, even the sterilized fermentation filtrate of Sneb207 could promote soybean seedlings growth significantly. The virulence effect of Sneb207 fermentation filtrate to different nematodes was tested. The result indicated Sneb207 had poisonous effect to nematodes. And significant virulence to different nematodes was detected,the sequence of virulence from high to lower was Heterodera glycines, Meloidogyne hapla, Aphelenchiodes besseyi, Ditylenchus destructor. The virulence of different concentrations of Sneb207 fermentation filtrate to Heterodera glycines was also tested. It proved bacteria Sneb207 was an effective biological agent to control soybean cyst nematode (SCN) and promote soybean growth.

  4. OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in Acinetobacter pittii from Spain.

    Science.gov (United States)

    Cayô, Rodrigo; Merino, María; Ruiz Del Castillo, Belén; Cano, María Eliecer; Calvo, Jorge; Bou, Germán; Martínez-Martínez, Luis

    2014-08-01

    A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel bla(OXA-207) gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin.

  5. [Effect of solcoseryl and combined therapy of solcoseryl and FT-207 for mice bearing meth-A tumor].

    Science.gov (United States)

    Iwasa, H; Mimura, K; Ohsaki, Y; Kanabe, S; Hiraide, H; Mizoguchi, O; Tamaki, K; Kurokawa, T; Hatsuse, K; Kadota, T; Ezoe, I; Tsuru, S; Zinnaka, Y

    1983-02-01

    The effects of a combined chemotherapy of solcoseryl and FT-207 on tumor growth, delayed hypersensitivity and cell population of the spleen were studied using inbred BALB/c mice. Meth-A tumor cells (2 X 10(6] were inoculated into the back of 5 to 6 week old BALB/c male mouse. Animals were divided into three groups: Solcoseryl group, in which 0.04 mg of solcoseryl was injected intravenously three times before inoculation and four times after inoculation; Combined group, in which 1.2 mg of FT-207 and 0.04 mg of solcoseryl were injected intravenously four times after inoculation; FT-207 group, in which 1.2 mg of FT-207 was injected four times after inoculation, with out solcoseryl administration. Following results were obtained: Solcoseryl group showed enhanced immunity and tumor suppression; Decreased immunity due to FT-207 was recovered by administration of solcoseryl but no tumor suppression was observed and, Decreased T-cell population of spleen due to FT-207 was recovered by administration of solcoseryl. These facts suggested that solcoseryl was useful because of making recovery possible from decreased immunity due to chemotherapy.

  6. Lead 207, 208 (n, xn gamma) reactions for neutron energies up to 200 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Pavlik, A.; Vonach, H. [Univ. Wien (Austria). Inst. fuer Radiumforschung und Kernphysik; Chadwick, M.B.; Haight, R.C.; Nelson, R.O.; Wender, S.A.; Young, P.G. [Los Alamos National Lab., NM (United States)

    1994-07-01

    High-resolution {gamma}-ray spectra from the interaction of neutrons in the energy range from 3 to 200 MeV with {sup 207,208}Pb were measured with the white neutron source at the WNR facility at Los Alamos National Laboratory. From these data, excitation functions for prominent {gamma} transitions in {sup 200,202,204,206,207,208}Pb were derived from threshold to 200 MeV incident neutron energy. These {gamma}-production cross sections represent formation cross sections for excited states of the residual nuclei. The results are compared with the predictions of nuclear reaction calculations based on the exciton model for precompound emission, the Hauser-Feshbach theory for compound nuclear decay, and coupled channels calculations to account for direct excitation of collective levels. Good agreement was obtained over the entire energy range covered in the experiment with reasonable model parameters. The results demonstrate that multiple preequilibrium emission has to be taken into account above about 40 MeV, and that the level density model of Ignatyuk should be used instead of the Gilbert-Cameron and back-shifted Fermi-gas models if excitation energies exceed about 30 MeV.

  7. Parameters influencing Agrobacterium-mediated transformation system in safflower genotypes AKS-207 and PKV Pink.

    Science.gov (United States)

    Dhumale, Dipti Raghunath; Shingote, Prashant Raghunath; Dudhare, Mahendra Shankarrao; Jadhav, Pravin Vishwanath; Kale, Prashant Bhaskar

    2016-12-01

    Shoot regeneration in safflower (Carthamus tinctorius 'AKS 207' and 'PKV Pink') genetically transformed using Agrobacterium was used for assessing various constraints to the efficiency of transformation including infection period, virulence induction medium, co-cultivation period, bacterial titre, selection regime, and the natural phenolic compound acetosyringone. Transformation frequency was promising with 8-10-day-old cotyledonary leaf explants. Therefore, explants of that age cultured on Agrobacterium minimal medium (AB) containing 100 µM acetosyringone were infected with Agrobacterium (cell titre 0.5 OD600nm) for 15 min followed by 48 h of co-cultivation on kanamycin-enriched medium (50 mg/L). Transformation of the shoots was confirmed using β-glucuronidase (GUS) histochemical assay and polymerase chain reaction (PCR). With the transformation protocol thus optimized, the transformation frequency as determined using GUS assays was 54.0 % for AKS 207 and 47.6 % for PKV Pink. The corresponding figures using PCR were 27.0 and 33.3 %. The transformed shoots required 10-14 weeks of culture initiation but produced very few roots.

  8. Measurement of the L/K electron capture ratio of the {sup 207}Bi decay to the 1633 keV level of {sup 207}Pb with a BGO scintillating bolometer

    Energy Technology Data Exchange (ETDEWEB)

    Coron, N.; Gironnet, J.; Marcillac, P. de; Martinez, M.; Redon, T.; Torres, L. [Universite Paris-Sud 11 et CNRS (UMR 8617), Institut d' Astrophysique Spatiale, Orsay (France); Cuesta, C.; Garcia, E.; Ginestra, C.; Ortigoza, Y.; Pobes, C.; Puimedon, J.; Salinas, A.; Sarsa, M.L. [Universidad de Zaragoza, Grupo de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Watrin, A. [Universidad de Zaragoza, Grupo de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Universite Louis Pasteur, Ecole nationale superieure de physique de Strasbourg (ENSPS), Illkirch (France)

    2012-06-15

    The ROSEBUD Collaboration has dedicated several underground runs to study different types of bolometers, mainly for the search of dark matter. Some of these runs, profiting from the good energy resolution of one bolometer of BGO and the ultra-low background of the underground laboratory of Canfranc (LSC), allowed the measurement of the L/K electron capture ratio of the {sup 207}Bi decay to the 1633 keV level of {sup 207}Pb. This paper constitutes the first published measurement of this magnitude. (orig.)

  9. Interactions of 160 GeV/Nucleon $^{207}$Pb Nuclei in Emulsion Chambers with Copper and Lead Targets

    CERN Multimedia

    2002-01-01

    % EMU13 \\\\ \\\\ Nuclear emulsions will be used as targets and trackers to investigate the interactions of $^{207}$Pb nuclei in emulsion, copper and lead targets; specifically (i) the pseudorapidity distributions of charged particles including analysis of particle fluctuations in pseudorapidity and azimuthal angle distributions, (ii) the transverse momentum distribution of $\\alpha$ fragments from the projectile nucleus. \\\\ \\\\Several emulsion chambers with different geometry and targets will be exposed to the $^{207}$Pb beam. Each chamber will be irradiated with the beam of low density $^{207}$Pb ions (several hundred per cm$^2$). Interactions with small impact parameter, characterized by high multiplicity and disruption of the projectile nucleus will be found with high efficiency. Measurements in the emulsion will include the number and emission angles of charged particles produced and the emission angles of $\\alpha$ fragments from the projectile nucleus.

  10. 31 CFR 363.207 - Can I transfer my marketable Treasury security from my TreasuryDirect ® account to another...

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Can I transfer my marketable Treasury security from my TreasuryDirect ® account to another TreasuryDirect account? 363.207 Section 363.207 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE,...

  11. 33 CFR 207.170b - Apopka-Beauclair Navigation Lock in Apopka-Beauclair Canal in Lake County, Fla.; use...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Apopka-Beauclair Navigation Lock in Apopka-Beauclair Canal in Lake County, Fla.; use, administration, and navigation. 207.170b Section 207.170b Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS §...

  12. A novel microtubule inhibitor 4SC-207 with anti-proliferative activity in taxane-resistant cells.

    Directory of Open Access Journals (Sweden)

    Elena Bausch

    Full Text Available Microtubule inhibitors are invaluable tools in cancer chemotherapy: taxanes and vinca alkaloids have been successfully used in the clinic over the past thirty years against a broad range of tumors. However, two factors have limited the effectiveness of microtubule inhibitors: toxicity and resistance. In particular, the latter is highly unpredictable, variable from patient to patient and is believed to be the cause of treatment failure in most cases of metastatic cancers. For these reasons, there is an increasing demand for new microtubule inhibitors that can overcome resistance mechanisms and that, at the same time, have reduced side effects. Here we present a novel microtubule inhibitor, 4SC-207, which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. In summary, our results suggest that 4SC-207 may be a potential anti-cancer agent.

  13. 代谢综合征207例患者健康管理的对比分析%Health management and metabolic syndrome in 207 employees

    Institute of Scientific and Technical Information of China (English)

    夏燕妮; 姜海伟; 李晨; 翟莎

    2011-01-01

    Objective To analyze the effects of health management of metabolic syndrome on the control of related risk factors. Methods A total of 430 patients diagnosed with metabolic syndrome in 2008completed questionnaire and before randomly assigned to the health management group ( n = 207 ) and the control group (n=223). One year later, all the participants were investigated for the risk factors of food intake, cigarette smoking, alcohol consumption, staying-up and emotion, and the changes of body mass index ( BMI), blood pressure ( BP), triglyceride (TG), high-density lipoprotein cholesterol (HDL) and fasting blood glucose (FBG). Student's t test and x2 test were used for data analysis. Results For the health management group, the incidence of high-salt, high-fat and high-sugar intake, overtake of food, lack of physical exercises,staying-up and alcohol drinking was significantly decreased at 1 year (P < 0. 05 ), when compared with baseline and the control group ( both P < 0. 05 ). For the health management group, BMI,systolic blood pressure (SBP),TG and FBG was improved at 1 year (P<0. 05). In comparison with the control group, BMI, SBP, diastolic blood pressure (DBP),TG and FBG of the management group were significantly improved (P < 0. 05 ). Conclusions Patients with metabolic syndrome may have better treatment compliance after receiving systematized and individualized health management.%目的 通过对武汉市某单位职工代谢综合征的健康管理效果观察,对比分析健康管理对于相关危险因素的发生率及代谢综合征相关指标的影响.方法 将2008年某单位体检中诊断为代谢综合征430例患者,通过问卷调查收集的健康信息进行健康风险因素分析;通过随机分组将207例自愿参与健康管理者作为管理组,管理组给予系统化的健康管理,其余223例作为对照组,仅给予一般性的健康指导及建议,一年后通过再次体检及问卷调查结果对比分析饮食、吸烟

  14. Analysis of 207 Cases of Medication Errors in Outpatient Department of Our Hospital%我院门诊207例用药错误分析

    Institute of Scientific and Technical Information of China (English)

    王璐; 董艳; 李彤; 周庆梅; 杜广清

    2016-01-01

    目的:为临床合理用药提供参考。方法:对我院2014年10月-2015年9月门诊药房报告的用药错误(ME)案例进行分析,包括ME分级、分类、发生原因、发生和发现ME的人员情况及构成比。结果:207例报告中无A级错误,B级错误199例,C级错误8例,无D~I级错误。其中,医师处方错误162例(78.26%),药师调剂错误45例(21.74%),排名前3位的医师处方错误依次为用法用量不当(42.59%)、给药途径不当(40.74%)和溶剂不适宜(5.56%);排名前3位的药师调剂错误依次为品种错误(40.00%)、规格错误(28.89%)和数量错误(24.44%)。医师处方错误的原因主要是信息系统不完善(56.17%)和医师不了解药物信息(43.83%);药师调剂错误的主要原因是药品一品多规(35.56%)、名称相似(28.89%)和人员疲劳(26.67%)。发现ME的人员中,药师、护士和患者或家属占比分别为97.58%、1.45%和0.97%。结论:进一步加强医院信息化建设,同时加强医师和药师的在岗培训,可以在一定程度上减少ME的发生。%OBJECTIVE:To provide reference for clinical rational drug use. METHODS:Medication error(ME)cases report-ed from outpatient department from Oct. 2014 to Sept. 2015 in our hospital were analyzed,including ME category,classification, cause and proportion of persons who triggered or detected ME. RESULTS:Among 207 reports,there was no case of category A, 199 cases of category B,8 cases of category C,no of categories D-I. Among them,162 cases occurred in the links of prescrip-tions by doctors (78.26%),45 cases (21.74%) occurred in the links of dispensing prescriptions by pharmacists,the top 3 ME were improper usage(42.59%),improper administration route(40.74%)and inappropriate solvent(5.56%);the top 3 dispensing errors were variety error(40.00%),specification error(28.89%)and number errors(24.44%). The main

  15. CD1c-related DCs that express CD207/langerin, but are distinguishable from Langerhans cells, are consistently present in human tonsils

    Directory of Open Access Journals (Sweden)

    Anne eDe Monte

    2016-05-01

    Full Text Available Several subsets of dendritic cells (DCs are present in the oropharyngeal tonsillar tissues and are thought to behave as major actors in development and regulation of immunity by acting as a first line of recognition for airborne and alimentary antigens. We previously discovered in human adult tonsils infected with Epstein-Barr Virus (EBV a subset of DCs that expressed langerin/CD207, a lectin usually recognized as a hallmark of epidermal Langerhans cells (LCs. In the present study, we analyzed the content of several child and adult tonsils in order to characterize in more detail the phenotype of these tonsillar CD207-expressing DCs (tCD207 DCs and to compare it with that of other human DC subsets. We showed that all the human tonsils studied (n=12 contained significant proportions of tCD207 DCs among tonsillar cells expressing HLA-DR. Moreover, the presence of tCD207 DCs in tonsils from young children free of EBV infection indicated that these cells could be established early in the tonsil independently of EBV infection. We also showed that tCD207 DCs, that were found mainly located within the tonsillar lymphoid stroma, were distinguishable from LCs by the level of expression of CD1a and EpCAM, and also from human inflammatory DCs (infDCs by the lack of CD1a, CD206 and CD14 expression. Detailed analysis of cell surface DC markers showed that tCD207 DCs were unrelated to CD141+ DCs or macrophages, but defined a subtype of tonsillar DCs closely related to myeloid resident CD1c DCs. Since it was established that blood CD1c myeloid DCs exhibit plasticity and are capable of expressing CD207 notably in the presence of inflammatory cytokines, it is tempting to speculate that CD207+ CD1c+ DCs may play a specific immune role.

  16. CD1c-Related DCs that Express CD207/Langerin, but Are Distinguishable from Langerhans Cells, Are Consistently Present in Human Tonsils.

    Science.gov (United States)

    De Monte, Anne; Olivieri, Charles-Vivien; Vitale, Sébastien; Bailleux, Sonanda; Castillo, Laurent; Giordanengo, Valérie; Maryanski, Janet L; Segura, Elodie; Doglio, Alain

    2016-01-01

    Several subsets of dendritic cells (DCs) are present in the oropharyngeal tonsillar tissues and are thought to behave as major actors in development and regulation of immunity by acting as a first line of recognition for airborne and alimentary antigens. We previously discovered in human adult tonsils infected with Epstein-Barr virus (EBV), a subset of DCs that expressed langerin/CD207, a lectin usually recognized as a hallmark of epidermal Langerhans cells (LCs). In the present study, we analyzed the content of several child and adult tonsils in order to characterize in more detail the phenotype of these tonsillar CD207-expressing DCs (tCD207 DCs) and to compare it with that of other human DC subsets. We showed that all the human tonsils studied (n = 12) contained significant proportions of tCD207 DCs among tonsillar cells expressing HLA-DR. Moreover, the presence of tCD207 DCs in tonsils from young children free of EBV infection indicated that these cells could be established early in the tonsil independently of EBV infection. We also showed that tCD207 DCs, that were found mainly located within the tonsillar lymphoid stroma, were distinguishable from LCs by the level of expression of CD1a and EpCAM, and also from human inflammatory DCs by the lack of CD1a, CD206, and CD14 expression. Detailed analysis of cell surface DC markers showed that tCD207 DCs were unrelated to CD141(+) DCs or macrophages, but defined a subtype of tonsillar DCs closely related to myeloid resident CD1c DCs. Since it was established that blood CD1c myeloid DCs exhibit plasticity and are capable of expressing CD207 notably in the presence of inflammatory cytokines, it is tempting to speculate that CD207(+) CD1c(+) DCs may play a specific immune role.

  17. Update of the BIPM comparison BIPM.RI(II)-K1.Bi-207 of activity measurements of the radionuclide 207Bi to include the 2010 result of the LNE-LNHB (France)

    Science.gov (United States)

    Michotte, C.; Ratel, G.; Courte, S.; Bobin, C.; Moune, M.

    2015-01-01

    In 2010, the Laboratoire National de Métrologie et d'Essais-Laboratoire National Henri Becquerel (LNE-LNHB) submitted one sample of known activity of 207Bi to the International Reference System for activity comparison at the Bureau International des Poids et Mesures, with comparison identifier BIPM.RI(II)-K1.Bi-207. The value of the activity submitted was about 180 kBq. There is now one result in the BIPM.RI(II)-K1.Bi-207 comparison. The key comparison reference value (KCRV) has been evaluated for the first time using the LNE-LNHB result and a PTB result dating 1982. The degree of equivalence between the LNE-LNHB equivalent activity measured in the SIR and the KCRV has been calculated and is reported. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  18. Draft Genome Sequences of the Antimicrobial Producers Pseudomonas sp. TAA207 and Pseudomonas sp. TAD18 Isolated from Antarctic Sediments

    Science.gov (United States)

    Presta, Luana; Inzucchi, Ilaria; Bosi, Emanuele; Fondi, Marco; Perrin, Elena; Maida, Isabel; Miceli, Elisangela; Tutino, Maria Luisa; Lo Giudice, Angelina; de Pascale, Donatella

    2016-01-01

    We report here the draft genome sequence of the Pseudomonas sp. TAA207 and Pseudomonas sp. TAD18 strains, isolated from Antarctic sediments during a summer campaign near coastal areas of Terra Nova Bay (Antarctica). Genome sequence knowledge allowed the identification of genes associated with the production of bioactive compounds and antibiotic resistance. Furthermore, it will be instrumental for comparative genomics and the fulfillment of both basic and application-oriented investigations. PMID:27469957

  19. G 207-9 and LP 133-144: light-curve analysis and asteroseismology of two ZZ Ceti stars

    Science.gov (United States)

    Bognár, Zs.; Paparó, M.; Molnár, L.; Pápics, P. I.; Plachy, E.; Verebélyi, E.; Sódor, Á.

    2016-10-01

    G 207-9 and LP 133-144 are two rarely observed ZZ Ceti stars located in the middle and close to the blue edge of the ZZ Ceti instability domain, respectively. We aimed to observe them at least during one observing season at Konkoly Observatory with the purpose of extending the list of known pulsation modes for asteroseismic investigations and detect any significant changes in their pulsational behaviour. We determined five and three new normal modes of G 207-9 and LP 133-144, respectively. In LP 133-144, our frequency analysis also revealed that at least at three modes there are actually triplets with frequency separations of ˜ 4 μHz. The rotational period of LP 133-144 based on the triplets is ≃42 h. The preliminary asteroseismic fits of G 207-9 predict Teff = 12 000 or 12 400 K and M_{ast }=0.855-0.870 M_{⊙} values for the effective temperature and mass of the star, depending on the assumptions on the spherical degree (l) values of the modes. These results are in agreement with the spectroscopic determinations. In the case of LP 133-144, the best-fitting models prefer Teff = 11 800 K in effective temperature and M* ≥ 0.71 M⊙ stellar masses, which are more than 0.1 M⊙ larger than the spectroscopic value.

  20. DNP-enhanced ultrawideline (207)Pb solid-state NMR spectroscopy: an application to cultural heritage science.

    Science.gov (United States)

    Kobayashi, Takeshi; Perras, Frédéric A; Murphy, Anna; Yao, Yao; Catalano, Jaclyn; Centeno, Silvia A; Dybowski, Cecil; Zumbulyadis, Nicholas; Pruski, Marek

    2017-03-14

    Dynamic nuclear polarization (DNP) is used to enhance the (ultra)wideline (207)Pb solid-state NMR spectra of lead compounds of relevance in the preservation of cultural heritage objects. The DNP SSNMR experiments enabled, for the first time, the detection of the basic lead carbonate phase of the lead white pigment by (207)Pb SSNMR spectroscopy. Variable-temperature experiments revealed that the short T'2 relaxation time of the basic lead carbonate phase hinders the acquisition of the NMR signal at room temperature. We additionally observe that the DNP enhancement is twice as large for lead palmitate (a lead soap, which is a degradation product implicated in the visible deterioration of lead-based oil paintings), than it is for the basic lead carbonate. This enhancement has allowed us to detect the formation of a lead soap in an aged paint film by (207)Pb SSNMR spectroscopy; which may aid in the detection of deterioration products in smaller samples removed from works of art.

  1. A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin.

    Science.gov (United States)

    Doctrow, Susan R; Lopez, Argelia; Schock, Ashley M; Duncan, Nathan E; Jourdan, Megan M; Olasz, Edit B; Moulder, John E; Fish, Brian L; Mäder, Marylou; Lazar, Jozef; Lazarova, Zelmira

    2013-04-01

    In the event of a radionuclear attack or nuclear accident, the skin would be the first barrier exposed to radiation, though skin injury can progress over days to years following exposure. Chronic oxidative stress has been implicated as being a potential contributor to the progression of delayed radiation-induced injury to skin and other organs. To examine the causative role of oxidative stress in delayed radiation-induced skin injury, including impaired wound healing, we tested a synthetic superoxide dismutase (SOD)/catalase mimetic, EUK-207, in a rat model of combined skin irradiation and wound injury. Administered systemically, beginning 48 hours after irradiation, EUK-207 mitigated radiation dermatitis, suppressed indicators of tissue oxidative stress, and enhanced wound healing. Evaluation of gene expression in irradiated skin at 30 days after exposure revealed a significant upregulation of several key genes involved in detoxication of reactive oxygen and nitrogen species. This gene expression pattern was primarily reversed by EUK-207 therapy. These results demonstrate that oxidative stress has a critical role in the progression of radiation-induced skin injury, and that the injury can be mitigated by appropriate antioxidant compounds administered 48 hours after exposure.

  2. G 207-9 and LP 133-144: light curve analysis and asteroseismology of two ZZ Ceti stars

    CERN Document Server

    Bognár, Zs; Molnár, L; Pápics, P I; Plachy, E; Verebélyi, E; Sódor, Á

    2016-01-01

    G 207-9 and LP 133-144 are two rarely observed ZZ Ceti stars located in the middle and close to the blue edge of the ZZ Ceti instability domain, respectively. We aimed to observe them at least during one observing season at Konkoly Observatory with the purpose of extending the list of known pulsation modes for asteroseismic investigations and detect any significant changes in their pulsational behaviour. We determined five and three new normal modes of G 207-9 and LP 133-144, respectively. In LP 133-144, our frequency analysis also revealed that at least at three modes there are actually triplets with frequency separations of ~4 microHz. The rotational period of LP 133-144 based on the triplets is ~42 h. The preliminary asteroseismic fits of G 207-9 predict Teff=12 000 or 12 400 K and M*=0.855-0.870 MSun values for the effective temperature and mass of the star, depending on the assumptions on the spherical degree (l) values of the modes. These results are in agreement with the spectroscopic determinations. I...

  3. Candida Osteomyelitis: Analysis of 207 Pediatric and Adult Cases (1970–2011)

    Science.gov (United States)

    Gamaletsou, Maria N.; Kontoyiannis, Dimitrios P.; Sipsas, Nikolaos V.; Moriyama, Brad; Alexander, Elizabeth; Roilides, Emmanuel; Brause, Barry; Walsh, Thomas J.

    2012-01-01

    Background. The epidemiology, pathogenesis, clinical manifestations, management, and outcome of Candida osteomyelitis are not well understood. Methods. Cases of Candida osteomyelitis from 1970 through 2011 were reviewed. Underlying conditions, microbiology, mechanisms of infection, clinical manifestations, antifungal therapy, and outcome were studied in 207 evaluable cases. Results. Median age was 30 years (range, ≤ 1 month to 88 years) with a >2:1 male:female ratio. Most patients (90%) were not neutropenic. Localizing pain, tenderness, and/or edema were present in 90% of patients. Mechanisms of bone infection followed a pattern of hematogenous dissemination (67%), direct inoculation (25%), and contiguous infection (9%). Coinciding with hematogenous infection, most patients had ≥2 infected bones. When analyzed by age, the most common distribution of infected sites for adults was vertebra (odds ratio [OR], 0.09; 95% confidence interval [CI], .04–.25), rib, and sternum; for pediatric patients (≤18 years) the pattern was femur (OR, 20.6; 95% CI, 8.4–48.1), humerus, then vertebra/ribs. Non-albicans Candida species caused 35% of cases. Bacteria were recovered concomitantly from 12% of cases, underscoring the need for biopsy and/or culture. Candida septic arthritis occurred concomitantly in 21%. Combined surgery and antifungal therapy were used in 48% of cases. The overall complete response rate of Candida osteomyelitis of 32% reflects the difficulty in treating this infection. Relapsed infection, possibly related to inadequate duration of therapy, occurred among 32% who ultimately achieved complete response. Conclusions. Candida osteomyelitis is being reported with increasing frequency. Localizing symptoms are usually present. Vertebrae are the most common sites in adults vs femora in children. Timely diagnosis of Candida osteomyelitis with extended courses of 6–12 months of antifungal therapy, and surgical intervention, when indicated, may improve

  4. Caracterización de tres nuevas variedades de vignas (‘IPA 206’ e ‘IPA 207’ y ‘Guariba’ en Cuba.

    Directory of Open Access Journals (Sweden)

    Yadelys Figueroa Aguila

    2012-07-01

    Full Text Available RESUMEN La investigación se desarrolló sobre un suelo Pardo mullido medianamente lavado con las variedades de vignas (‘IPA 206’, ‘IPA 207’ y ‘Guariba’ de reciente introducción en nuestro país. Tiene como principal objetivo caracterizar las variedades (‘IPA 206, ‘IPA 207’ y ‘Guariba’ bajo nuestras condiciones climáticas. Teniendo como principales resultados que se logró incluir en el registro de variedades según la caracterización desarrollada por nuestro instituto utilizando dos épocas de siembra, el hábitos de crecimiento indeterminado con vainas distribuidas por toda la planta se destaca en las variedades ‘IPA 206’ e ‘IPA 207’, mientras que en la ‘Guariba’ es determinado encontrándose estas distribuidas por encima de la planta, en cuanto al rendimiento, la variedad ‘IPA 207’ es superiores que la obtenida por la ‘'PA 206’ y ‘Guariba’, el peso de 1000 semillas en las variedades ‘Guariba’ y ‘IPA 206’ son superiores al peso de la ‘IPA 207’, la variedad ‘Guariba’ es económicamente más rentable que las ‘IPA 206’ y ‘IPA 207’ por emplear un número de cosechas muy inferior a las antes mencionadas. Puede sembrarse durante todas las épocas del año, pero lo más aconsejable es en época de frío para la obtención de semilla y el verano para la producción donde es más productiva y puede sustituir al fríjol común. Tolera estrés hídrico y régimen de abundantes lluvias, excepto en el momento de la cosecha y no admite el encharcamiento. Characterization of three new varieties vignas (' IPA 206' and ' IPA 207' y 'Guariba' in Cuba. ABSTRACT The research was conducted on a fairly soft Brown soil washing vignas varieties ('IPA 206', 'IPA 207' and 'Guariba' recently introduced in our country. Its main objective is to characterize varieties ('IPA 206,' IPA 207 'and' Guariba ' under our climatic conditions. Having as main results achieved include in the record as the

  5. Retrospective Cohort Study of 207 Cases of Osteochondritis Dissecans of the Knee

    Science.gov (United States)

    Green, Daniel W.; Arbucci, John; Silberman, Jason; Luderowski, Eva; Uppstrom, Tyler J.; Nguyen, Joseph; Tuca, Maria

    2016-01-01

    Objectives: Describe the clinical characteristics, image findings, and outcomes of patients with juvenile osteochondritis dissecans (JOCD) of the knee. To our knowledge, this is the largest single-surgeon cohort of JOCD patients. Methods: Retrospective cohort study of knee JOCD patients assessed by a single pediatric orthopaedic surgeon at a tertiary care center between 2005-2015. All diagnoses were confirmed by magnetic resonance imaging (MRI). Patients with patellar dislocations or osteochondral fractures were excluded. Demographic data, sports played, comorbidities, surgical procedures, and clinical data were extracted from charts. Images were analyzed to identify the location and size of lesions. Chi-square or Fisher’s exact tests were used to compare discrete variables, and Mann-Whitney U and Kruskal Wallis tests to compare continuous variables between groups. P-values of <0.05 were considered significant. Results: Sample consisted of 180 patients (207 knees), 124 boys and 56 girls. Average age at diagnosis was 12.8 years (7.5-17.5). Majority were active in sports (80.8%), primary soccer (36.7%) and basketball (29.4%). JOCD was present bilaterally in 27 patients (15%), 14 knees had bifocal OCD (6.8%), and only 1 patient had bifocal lesions in both knees. Most common location was medial femoral condyle (56.3%) followed by lateral femoral condyle (23.1%), trochlea (11.4%), patella (9%), and tibia (0.5%). In the sagittal view, most common location was the middle third of the condyles (48.7%). Surgery was performed in 72 knees (34.8%), with an average age at surgery of 14.1 years (9.3-18.1). Bilateral JOCD was present in 13 surgical patients (18.8%), but only 3 patients had bilateral surgery. Two operative patients had bifocal JOCD (2.7%) and surgery on both lesions. Location distribution did not differ between surgical and non-surgical lesions. The average normalized area of non-surgical JOCD lesions was 6.8 (0.1-18), whereas surgical lesions averaged a

  6. Outcome of oral dysplasia: a retrospective hospital-based study of 207 patients with a long follow-up.

    Science.gov (United States)

    Arduino, Paolo G; Surace, Antonio; Carbone, Mario; Elia, Alessandra; Massolini, Gianluca; Gandolfo, Sergio; Broccoletti, Roberto

    2009-07-01

    The aim of this retrospective hospital-based study was to review and evaluate the long-term outcome of patients with oral epithelial dysplasia (OED), with or without surgical intervention, to identify factors affecting clinical course and malignant evolution. Patients with a follow-up of at least 12 months were included. Data collected were statistically analyzed. The mean age was 63.58 years for women (n = 100) and 64.17 years for men (n = 107). One hundred and thirty-five of the patients had lesions with histopathological features of mild OED, 50 had moderate OED and 22 had severe OED. Gender and risk factors seemed not to be related with the development of OED. One hundred and thirty-three patients underwent active treatment. During the period considered, 39.4% of the 207 lesions disappeared; 19.66% remained stable and 33.7% of the total cases showed a new dysplastic event after treatment. Fifteen (7.24%) out of 207 developed a squamous cell carcinoma during follow-up. Our data showed that speckled lesions are more often associated with high histological grade. The risk of malignant development does not seem to be predictable. Surrounded by the limitations of the retrospective designs, we have showed that there is no eminent benefit of surgical intervention of OED in preventing recurrences and malignant development.

  7. Neutron particle-hole electric dipole states in /sup 206/ /sup 207/ /sup 208/Pb. [16. 2 to 17. 8 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Dickey, P.A.

    1979-01-01

    Inelastic proton scattering on /sup 206/Pb, /sup 207/Pb, and /sup 208/Pb through isobaric analog resonances was used to study neutron particle-hole excitations with large ground-state gamma branches in these Pb isotopes. Relative (p,p') cross sections at 90/sup 0/ are extracted for structures selectively excited on the d/sub 5/2/, s/sub 1/2/, and d/sub 3/2/-g/sub 7/2/ resonances. Interpretation of excitations in /sup 206/Pb and /sup 207/Pb in terms of coupling to states in /sup 208/Pb is discussed. Branching ratios for 1/sup -/ states in /sup 208/Pb at 4.84, 5.29, 5.94, and 6.31 MeV and the 1/2/sup +/ state in /sup 207/Pb at 4.63 MeV are deduced. 15 figures, 4 tables.

  8. Clinical data analysis of onychomycosis in 207 inpatients with diabetes%糖尿病住院患者207例甲真菌病临床调查研究

    Institute of Scientific and Technical Information of China (English)

    范娟; 卜晓琳; 胡晓莉; 蒋建华; 张际晨

    2016-01-01

    目的:调查研究糖尿病住院患者合并甲真菌病的患病率、临床分型及菌种构成。方法以2014年6-12月207例我院糖尿病住院患者为研究对象,调查分析糖尿病住院患者甲真菌病的患病率、临床分型及菌种构成等。结果207例糖尿病住院患者甲真菌病的临床分型为远端侧位甲下型(42.9%)、全甲毁损型(38.1%)、近端甲下型(14.3%)、浅表白色型(4.8%);糖尿病住院患甲真菌病的患病率为10.1%;致病菌主要为皮肤癣菌和酵母菌。结论糖尿病患者甲真菌病的发病率高于普通人群的平均发病率,临床分型以远端侧位甲下型为主,病原菌主要是皮肤癣菌和酵母菌。%Objective To investigate and analyze the incidence of onychomycosis coupled with diabetes in the inpatients, the clinical classification of the disease and species composition.Methods Two hundred and seven patients with diabetes admitted into our hospital from June 2014 to December 2014, were used as the research objects.The incidence of onychomycosis, the clinical classifica-tion of the disease and species composition were investigated and analyzed in the inpatients coupled with diabetes.Results The clinical classifications of onychomycosis in 207 inpatients coupled with diabetes were DLSO (accounting for 42.9%), TDO (accounting for 38.1%), PSO (accounting for 14.3%) and SWO (accounting for 4.8%).The incidence of onychomycosis in diabetic inpatients was 10.1%, with the main pathogens of the disease being dermatophyte and yeast.Conclusion The incidence of onychomycosis in diabetic inpatients was higher than that of the general population.Clinical classification of the disease was chiefly DLSO, with pathogens being dermatophyte and yeast.

  9. 标致207 1.6 THP Feline MINI Cooper Pepper 铃木雨燕 1.6 VVT Sport三小无猜

    Institute of Scientific and Technical Information of China (English)

    孟培

    2007-01-01

    @@ 207,不仅是它的名字,也是它的速度(更准确地说是206.958公里/小时).本次测试中,标致207稍稍胜出其它两个对手,它的发动机源于宝马公司,功率是三款车中最强的一个,舒适度也相对高出另两款轿车(双区自动空调),不过最后还是和铃木雨燕运动款打成了平手;

  10. 206Pb-230Th-234U-238U and 207Pb-235U geochronology of Quaternary opal, Yucca Mountain, Nevada

    Science.gov (United States)

    Neymark, Leonid A.; Amelin, Yuri V.; Paces, James B.

    2000-01-01

    U–Th–Pb isotopic systems have been studied in submillimeter-thick outermost layers of Quaternary opal occurring in calcite–silica fracture and cavity coatings within Tertiary tuffs at Yucca Mountain, Nevada, USA. These coatings preserve a record of paleohydrologic conditions at this site, which is being evaluated as a potential high-level nuclear waste repository. The opal precipitated from groundwater is variably enriched in 234U (measured 234U/238U activity ratio 1.124–6.179) and has high U (30–313 ppm), low Th (0.008–3.7 ppm), and low common Pb concentrations (measured 206Pb/204Pb up to 11,370). It has been demonstrated that the laboratory acid treatment used in this study to clean sample surfaces and to remove adherent calcite, did not disturb U–Th–Pb isotopic systems in opal. The opal ages calculated from 206Pb∗/238U and 207Pb∗/235U ratios display strong reverse discordance because of excess radiogenic 206Pb∗ derived from the elevated initial 234U. The data are best interpreted using projections of a new four-dimensional concordia diagram defined by 206Pb∗/238U, 207Pb∗/235U, 234U/238Uactivity, and 230Th/238Uactivity. Ages and initial 234U/238U activity ratios have been calculated using different projections of this diagram and tested for concordance. The data are discordant, that is observed 207Pb∗/235U ages of 170 ± 32 (2σ) to 1772 ± 40 ka are systematically older than 230Th/U ages of 34.1 ± 0.6 to 452 ± 32 ka. The age discordance is not a result of migration of uranium and its decay products under the open system conditions, but a consequence of noninstantaneous growth of opal. Combined U–Pb and 230Th/U ages support the model of slow mineral deposition at the rates of millimeters per million years resulting in layering on a scale too fine for mechanical sampling. In this case, U–Pb ages provide more accurate estimates of the average age for mixed multiage samples than 230Th/U ages, because ages based on shorter

  11. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  12. Isolation of Actinium from Neutron-irradiated Thorium-I

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Isolation of Actinium from Neutron-irradiated Thorium-I¥YangWeifan;YuanShuanggui;MuWantong;ZhangXueqian;LiZhongweiandZhaoLili...

  13. 20 CFR 10.207 - May an employee who returns to work, then stops work again due to the effects of the injury...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false May an employee who returns to work, then... Eligibility for Cop § 10.207 May an employee who returns to work, then stops work again due to the effects of the injury, receive COP? If the employee recovers from disability and returns to work, then...

  14. 40 CFR 600.207-08 - Calculation and use of vehicle-specific 5-cycle-based fuel economy values for vehicle...

    Science.gov (United States)

    2010-07-01

    .... (b) If only one equivalent petroleum-based fuel economy value exists for an electric configuration...-cycle fuel economy for that configuration. (c) If more than one equivalent petroleum-based 5-cycle fuel...-specific 5-cycle-based fuel economy values for vehicle configurations. 600.207-08 Section...

  15. 33 CFR 207.170d - Taylor Creek, navigation lock (S-193) across the entrance to Taylor Creek at Lake Okeechobee...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Taylor Creek, navigation lock (S-193) across the entrance to Taylor Creek at Lake Okeechobee, Okeechobee, Fla.; use, administration..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.170d Taylor Creek, navigation...

  16. Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients.

    Science.gov (United States)

    Hirai, Kelly Emi; Aarão, Tinara Leila de Sousa; Silva, Luciana Mota; de Sousa, Jorge Rodrigues; de Souza, Juarez; Dias, Leonidas Braga; Carneiro, Francisca Regina Oliveira; Fuzii, Hellen Thais; Quaresma, Juarez Antonio Simões

    2016-02-01

    The clinical course of infection with Mycobacterium leprae varies widely and depends on the pattern of the host immune response. Dendritic cells play an important role in the activation of the innate and adaptive immune system and seem to be essential for the development of the disease. To analyze the presence of epidermal dendritic cells (CD1a and CD207), plasmacytoid dendritic cells (CD123) and dermal dendrocytes (factor XIIIa) in lesion fragments of leprosy patients, skin samples from 30 patients were studied. These samples were submitted to immunohistochemistry against CD1a, CD207, FXIIIa, and CD123. The results showed a larger number of Langerhans cells, detected with the CD1a or CD207 marker, dermal dendrocytes and plasmacytoid dendritic cells in patients with the tuberculoid form. A positive correlation was observed between the Langerhans cell markers CD1a and CD207 in both the tuberculoid and lepromatous forms, and between Langerhans cells and dermal dendrocytes in samples with the tuberculoid form. The present results indicate the existence of a larger number of dendritic cells in patients at the resistant pole of the disease (tuberculoid) and suggest that the different dendritic cells studied play a role, favoring an efficient immune response against infection with M. leprae.

  17. Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide.

    Science.gov (United States)

    Wallis, Robert S; Jakubiec, Wesley; Mitton-Fry, Mark; Ladutko, Lynn; Campbell, Sheldon; Paige, Darcy; Silvia, Annette; Miller, Paul F

    2012-01-01

    There presently is no rapid method to assess the bactericidal activity of new regimens for tuberculosis. This study examined PNU-100480, TMC207, PA-824, SQ109, and pyrazinamide, singly and in various combinations, against intracellular M. tuberculosis, using whole blood culture (WBA). The addition of 1,25-dihydroxy vitamin D facilitated detection of the activity of TMC207 in the 3-day cultures. Pyrazinamide failed to show significant activity against a PZA-resistant strain (M. bovis BCG), and was not further considered. Low, mid, and high therapeutic concentrations of each remaining drug were tested individually and in a paired checkerboard fashion. Observed bactericidal activity was compared to that predicted by the sum of the effects of individual drugs. Combinations of PNU-100480, TMC207, and SQ109 were fully additive, whereas those including PA-824 were less than additive or antagonistic. The cumulative activities of 2, 3, and 4 drug combinations were predicted based on the observed concentration-activity relationship, published pharmacokinetic data, and, for PNU-100480, published WBA data after oral dosing. The most active regimens, including PNU-100480, TMC207, and SQ109, were predicted to have cumulative activity comparable to standard TB therapy. Further testing of regimens including these compounds is warranted. Measurement of whole blood bactericidal activity can accelerate the development of novel TB regimens.

  18. Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid, TMC207, PA-824, SQ109, and pyrazinamide.

    Directory of Open Access Journals (Sweden)

    Robert S Wallis

    Full Text Available There presently is no rapid method to assess the bactericidal activity of new regimens for tuberculosis. This study examined PNU-100480, TMC207, PA-824, SQ109, and pyrazinamide, singly and in various combinations, against intracellular M. tuberculosis, using whole blood culture (WBA. The addition of 1,25-dihydroxy vitamin D facilitated detection of the activity of TMC207 in the 3-day cultures. Pyrazinamide failed to show significant activity against a PZA-resistant strain (M. bovis BCG, and was not further considered. Low, mid, and high therapeutic concentrations of each remaining drug were tested individually and in a paired checkerboard fashion. Observed bactericidal activity was compared to that predicted by the sum of the effects of individual drugs. Combinations of PNU-100480, TMC207, and SQ109 were fully additive, whereas those including PA-824 were less than additive or antagonistic. The cumulative activities of 2, 3, and 4 drug combinations were predicted based on the observed concentration-activity relationship, published pharmacokinetic data, and, for PNU-100480, published WBA data after oral dosing. The most active regimens, including PNU-100480, TMC207, and SQ109, were predicted to have cumulative activity comparable to standard TB therapy. Further testing of regimens including these compounds is warranted. Measurement of whole blood bactericidal activity can accelerate the development of novel TB regimens.

  19. 13 CFR 126.207 - May a qualified HUBZone SBC have offices or facilities in another HUBZone or outside a HUBZone?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false May a qualified HUBZone SBC have... Assistance SMALL BUSINESS ADMINISTRATION HUBZONE PROGRAM Requirements to be a Qualified HUBZone SBC § 126.207 May a qualified HUBZone SBC have offices or facilities in another HUBZone or outside a HUBZone?...

  20. 20 CFR 661.207 - How does the State Board meet its requirement to conduct business in an open manner under the...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How does the State Board meet its requirement... State Governance Provisions § 661.207 How does the State Board meet its requirement to conduct business..., on a regular basis through open meetings, information about the activities of the State Board....

  1. Extended disease-free interval of 6 years in a recurrent glioblastoma multiforme patient treated with G207 oncolytic viral therapy

    Directory of Open Access Journals (Sweden)

    Whisenhunt Jr TR

    2015-01-01

    Full Text Available Thomas R Whisenhunt Jr, Kiran F Rajneesh, James R Hackney, James M Markert Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA Background: Glioblastoma multiforme (GBM is a relentless primary central nervous system malignancy that remains resistant to conventional therapy despite major advances in clinical neurooncology. This report details the case of a patient who had failed conventional treatment for recurrent GBM and was ultimately treated with a genetically engineered herpes simplex virus (HSV type 1 vector, G207. Methods: Case report detailing the outcomes of one patient enrolled into the gene therapy arm of the Neurovir G207 protocol whereby stereotactic injection of 120 µL G207 viral suspension containing 1×107 plaque-forming units (or active viral particles was made into the enhancing region of the tumor. Results: In this patient, despite aggressive surgical resection, adjuvant radiotherapy and chemotherapy, tumor progression occurred. However, with G207 oncolytic therapy and brief exposures to second and third treatments, this patient had an extended survival time of 7.5 years and a 6-year apparent disease-free interval, an extraordinarily unusual finding in the pretemozolomide era. Conclusion: With minimal adjunctive chemotherapy, including one course of temozolomide, one course of procarbazine, and four cycles of irinotecan, the patient survived over 7 years before the next recurrence. Addition of G207 to this patient’s traditional therapy may have been the critical treatment producing her prolonged survival. This report demonstrates the potential for long-term response to a one-time treatment with oncolytic HSV and encourages continued research on oncolytic viral therapy for GBM. Keywords: oncolytic virotherapy, malignant glioma, tumor, herpes simplex, HSV-1, immunotherapy

  2. First direct observation of bound-state beta-decay. Measurements of branching and lifetime of {sup 207}Tl{sup 81+} fragments

    Energy Technology Data Exchange (ETDEWEB)

    Boutin, D.

    2005-08-01

    The first experimental observation of bound-state beta-decay showed, that due solely to the electron stripping, a stable nuclide, e.g. {sup 163}Dy, became unstable. Also a drastic modification of the half-life of bare {sup 187}Re, from 4.12(2) x 10{sup 10} years down to 32.9(20) years, could be observed. It was mainly due to the possibility for the mother nuclide to decay into a previously inaccessible nuclear level of the daughter nuclide. It was proposed to study a nuclide where this decay mode was competing with continuum-state beta-decay, in order to measure their respective branchings. The ratio {beta}{sub b}/{beta}{sub c} could also be evaluated for the first time. {sup 207}Tl was chosen due to its high atomic number, and Q-value of about 1.4 MeV, small enough to enhance the {beta}{sub b} probability and large enough to allow the use of time-resolved Schottky Mass Spectrometry (SMS) to study the evolution of mother and bound-state beta-decay daughter ions. The decay properties of the ground state and isomeric state of {sup 207}Tl{sup 81+} have been investigated at the GSI accelerator facility in two separate experiments. For the first time {beta}-decay where the electron could go either to a bound state (atomic orbitals) and lead to {sup 207}Pb{sup 81+} as a daughter nuclide, or to a continuum state and lead to {sup 207}Pb{sup 82+}, has been observed. The respective branchings of these two processes could be measured as well. The deduced total nuclear half-life of 255(17) s for {sup 207}Tl{sup 81+}, was slightly modified with respect to the half-life of the neutral atom of 286(2) s. It was nevertheless in very good agreement with calculations based on the assumption that the beta-decay was following an allowed type of transition. The branching {beta}{sub b}/{beta}{sub c}=0.192(20), was also in very good agreement with the same calculations. The application of stochastic precooling allowed to observe in addition the 1348 keV short-lived isomeric state of {sup

  3. Electronic inhomogeneity and Ag:Sb imbalance of Ag1-yPb18/207Sb1+zTe20 high-performance thermoelectrics elucidated by 125Te and 207Pb NMR

    Energy Technology Data Exchange (ETDEWEB)

    Levin, E.M.; Cook, B.A.; Ahn, K.; Kanatzidis, M.G.; Schmidt-Rohr, K.

    2009-09-22

    Using magic-angle spinning {sup 125}Te and {sup 207}Pb NMR, we have discovered the presence of two phases of approximately tenfold different free-electron concentration, n, in high-performance thermoelectrics Ag{sub 1?y}Pb{sub 18}Sb{sub 1+z}Te{sub 20} (LAST-18), proven by pairs of Knight-shifted NMR peaks and biexponential spin-lattice relaxation. The ratio of the phases is typically 2:1 with n {approx} 2 x 10{sup 19} cm{sup -3} and 0.2 x 10{sup 19} cm{sup -3}, respectively, determined from the spin-lattice relaxation times. {sup 125}Te NMR spectra show that both phases contain similar concentrations of Sb. The low-n component is assigned to Ag-rich regions with Ag-Sb pairing (but not AgSbTe{sub 2}), the dominant high-n component to PbTe:Sb resulting from the excess of Sb relative to Ag. The electronic inhomogeneity observed here must be considered in the search for a better understanding of high-performance thermoelectric materials.

  4. Draft genome sequence of a multidrug-resistant New Delhi metallo-β-lactamase NDM-1-producing Acinetobacter pittii sequence type 207 isolate from China.

    Science.gov (United States)

    Wang, Jianfeng; Wu, Liyan; Xu, Liqun; Chen, Yu; Chen, Yan

    2016-09-01

    The increasing emergence of carbapenem-resistant Acinetobacter spp. worldwide has resulted in the limited availability of effective antimicrobial agents and has become a major public health concern. In this study, the draft genome sequence of Acinetobacter pittii TCM292 belonging to sequence type 207 (ST207), a multidrug-resistant (MDR) isolate harbouring the New Delhi metallo-β-lactamase blaNDM-1 gene, was determined using an Illumina HiSeq™ 2000 platform. The genome sequence was analysed by bioinformatics methods. The A. pittii TCM292 genome size was estimated to be 3791758bp with 3486 predicted coding regions. These data might facilitate further understanding of the specific genomic features of MDR A. pittii in China.

  5. A Study of $b\\overline{b}$ Production in $e^{+}e^{-}$ Collisions at $\\sqrt{s}$ = 130-207 GeV

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P.P; Amaldi, U; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W-D; Arnoud, Y; Ask, S; Asman, B; Augustin, J.E; Augustinus, A; Baillon, P; Ballestrero, A; Bambade, P; Barbier, R; Bardin, D; Barker, G.J; Baroncelli, A; Battaglia, M; Baubillier, M; Becks, K-H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N; Benvenuti, A; Berat, C; Berggren, M; Bertrand, D; Besancon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P.S.L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T.J.V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Bruckman, P; Brunet, J.M; Buschbeck, B; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F; Chapkin, M; Charpentier, Ph; Checchia, P; Chierici, R; Chliapnikov, P; Chudoba, J; Chung, S.U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M.J; Crennell, D; Cuevas, J; D'Hondt, J; da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; De Boer, W; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; de Paula, L; Di Ciaccio, L; Di Simone, A; Doroba, K; Drees, J; Eigen, G; Ekelof, T; Ellert, M; Elsing, M; Espirito Santo, M.C; Fanourakis, G; Fassouliotis, D; Feindt, M; Fernandez, J; Ferrer, A; Ferro, F; Flagmeyer, U; Foeth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J; Gandelman, M; Garcia, C; Gavillet, Ph; Gazis, E; Gokieli, R; Golob, B; Gomez-Ceballos, G; Goncalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Hoffman, J; Holmgren, S-O; Holt, P.J; Houlden, M.A; Jackson, J.N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E.K; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E; Kernel, G; Kersevan, B.P; Kerzel, U; King, B.T; Kjaer, N.J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kouznetsov, O; Krumstein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J.H; Lopez, J.M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Marechal, B; Margoni, M; Marin, J-C; Mariotti, C; Markou, A; Martinez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Migliore, E; Mitaroff, W; Mjoernmark, U; Moa, T; Moch, M; Monig, Klaus; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Mueller, U; Muenich, K; Mulders, M; Mundim, L; Murray, W; Muryn, B; Myatt, G; Myklebust, T; Nassiakou, M; Navarria, F; Nawrocki, K; Nemecek, S; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V; Olshevski, A; Onofre, A; Orava, R; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J.P; Palka, H; Papadopoulou, Th.D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M.E; Polok, G; Pozdniakov, V; Pukhaeva, N; Pullia, A; Radojicic, D; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P; Richard, F; Ridky, J; Rivero, M; Rodriguez, D; Romero, A; Ronchese, P; Roudeau, P; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovsky, A; Salmi, L; Salt, J; Sander, C; Savoy-Navarro, A; Schwickerath, U; Sekulin, R; Siebel, M; Sisakian, A; Smadja, G; Smirnova, O; Sokolov, A; Sopczak, A; Sosnowski, R; Spassov, T; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli, T; Tegenfeldt, F; Timmermans, J; Tkatchev, L; Tobin, M; Todorovova, S; Tome, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M-L; Tyapkin, I.A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; Van Dam, P; Van Eldik, J; van Remortel, N; Van Vulpen, I; Vegni, G; Veloso, F; Venus, W; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A.J; Weiser, C; Wicke, D; Wickens, J; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O; Zalewska, A; Zalewski, P; Zavrtanik, D; Zhuravlov, V; Zimin, N I; Zintchenko, A; Zupan, M

    2009-01-01

    Measurements are presented of R_b, the ratio of the b bbar cross-section to the q qbar cross-section in e+e- collisions, and the forward-backward asymmetry A^b_FB at twelve energy points in the range sqrt(s) = 130-207 GeV. These results are found to be consistent with the Standard Model expectations. The measurements are used to set limits on new physics scenarios involving contact interactions.

  6. CD1c-related DCs that express CD207/langerin, but are distinguishable from Langerhans cells, are consistently present in human tonsils

    OpenAIRE

    Anne eDe Monte; Charles-Vivien eOLIVIERI; Sebastien eVITALE; Sonanda eBAILLEUX; Laurent eCASTILLO; Valerie eGIORDANENGO; Maryanski, Janet L.; Elodie eSegura; Alain eDOGLIO

    2016-01-01

    Several subsets of dendritic cells (DCs) are present in the oropharyngeal tonsillar tissues and are thought to behave as major actors in development and regulation of immunity by acting as a first line of recognition for airborne and alimentary antigens. We previously discovered in human adult tonsils infected with Epstein-Barr Virus (EBV) a subset of DCs that expressed langerin/CD207, a lectin usually recognized as a hallmark of epidermal Langerhans cells (LCs). In the present study, we anal...

  7. CD1c-Related DCs that Express CD207/Langerin, but Are Distinguishable from Langerhans Cells, Are Consistently Present in Human Tonsils

    OpenAIRE

    De Monte, Anne; Olivieri, Charles-Vivien; Vitale, Sébastien; Bailleux, Sonanda; Castillo, Laurent; Giordanengo, Valérie; Maryanski, Janet L.; Segura, Elodie; Doglio, Alain

    2016-01-01

    Several subsets of dendritic cells (DCs) are present in the oropharyngeal tonsillar tissues and are thought to behave as major actors in development and regulation of immunity by acting as a first line of recognition for airborne and alimentary antigens. We previously discovered in human adult tonsils infected with Epstein–Barr virus (EBV), a subset of DCs that expressed langerin/CD207, a lectin usually recognized as a hallmark of epidermal Langerhans cells (LCs). In the present study, we ana...

  8. Tree rings as Pb pollution archives? A comparison of 206Pb/207Pb isotope ratios in pine and other environmental media.

    Science.gov (United States)

    Bindler, Richard; Renberg, Ingemar; Klaminder, Jonatan; Emteryd, Ove

    2004-02-05

    Tree rings, if validated as an environmental archive for pollution, would provide a convenient, geographically widespread archive for studying the temporal and spatial distribution of atmospheric pollutants. We collected tree-ring records from Scots pine (Pinus sylvestris L.), ranging in age from 100 to 300 years and from one spruce (Picea abies), from sites in southern and northern Sweden and analyzed their stable lead isotopic composition (206Pb/207Pb). These results are compared to the Pb isotopic composition in soil profiles from each of the sites and temporal changes in the 206Pb/207Pb ratio in peat and lake sediment deposits in Sweden. The mineral soils at each site are characterized by high 206Pb/207Pb ratios (> 1.35), while the ratios in the mor layer are low (1.14-1.16) and characterized by atmospheric lead pollution. The 206Pb/207Pb ratios of the tree rings, typically approximately 1.18-1.20, indicate a significant (10-30%) contribution of Pb derived from the underlying mineral soil. While peat and lake sediment records show that the 206Pb/207Pb ratio of atmospheric deposition has varied over time, with a pronounced trough between approximately 1930 and 1990, the tree rings show no similar trend. Further comparison of published Pb isotope data from other tree-ring records with time series from peat bogs and herbarium samples also shows poor agreement, and indicates that tree rings always contain a mixture of pollution Pb and Pb from the underlying mineral soil. The majority of Pb in the wood is derived from atmospheric pollution either directly, through aerial interception, or indirectly, through uptake from the large pool of accumulated pollution Pb in the soil. Since the Pb isotope ratios of the wood indicate that some natural Pb is taken up into the tree, then it must also be concluded that some fraction of the pollution Pb in the wood is likewise taken up from the forest soil. Based on the Pb isotope analyses, we can only conclude that dendrochemical

  9. 204 - 207 Suleiman

    African Journals Online (AJOL)

    DR. AMIN

    2011-12-02

    Dec 2, 2011 ... 100 g seed treatment exhibited a mean number of eggs laid / 20 seeds as 17.7 ... stomach poison since the weevils feed directly on the grains (Adedire and .... weevil, Callosobruchus analis F. Pakistan. Journal of Entomology ...

  10. Clinical characteristics of 207 measles cases with etiological diagnosis%经病原学确诊的207例儿童麻疹临床特征分析

    Institute of Scientific and Technical Information of China (English)

    黄辉; 邓莉; 郑崇光; 邓洁; 陈冬梅; 钱渊

    2012-01-01

    Objectives To understand the influence of measles vaccination on clinical manifestations of measles in children, different characteristics of measles in infants and children in order to improve early diagnosis of measles by analyzing the characteristics of measles cases with laboratory confirmed etiological data. Methods Clinical data were collected from children who visited the Department of Outpatient Infectious Diseases and hospitalized with clinical diagnosis of measles and confirmed by measles specific IgM and measles virus N gene fragment from January 2002 to December 2010. Measles specific IgM antibodies were tested using serum samples with ELISA. Measles virus N gene fragment was amplified from specimens of throat swabs and fresh urine by reverse transcription-polymerase chain reaction ( RT-PCR ). Analyses were performed in vaccinated and unvaccinated cased separately. Results ① In total, 207 cases of measles in children with etiological diagnosis were analyzed, including 123 males and 84 females, 53 vaccinated and 154 unvaccinated. Age distribution ranged from 0 to 15 years, including 69 cases ( 33. 3% ) of younger than 8 months ( who had not reached the age for primary measles vaccination ), and 45 cases ( 21. 7% ) of younger than 1 year of age. ②Cases with Beijing local residency was more common in vaccinated group than that in unvaccinated group. The peak incidence was found in April for all cases in two groups. 15.4% ( 24/154 ) cases with known exposure history in measles unvaccinated group and in unvaccinated group and 16. 9% ( 9/53 ) in measles vaccinated group, with no significant difference between two groups. ③The proportions of measles with symptoms of mucosa spots ( Koplik spots ) and cough were significantly lower in vaccinated group than in unvaccinated group while the other symptoms had no significant difference betweentwo groups. ④ Of 154 unvaccinated cases, 97 were younger than 1 and 57 older than 1 year old. Symptoms of eyes was

  11. Completion Report for Well ER-20-7: Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Restoration

    2010-04-28

    Well ER-20-7 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The well was drilled in June 2009 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to further investigate migration of radionuclides from the nearby, up-gradient TYBO and BENHAM underground nuclear tests, which originally was discovered at Well Cluster ER-20-5. This well also provided detailed hydrogeologic information in the Tertiary volcanic section that will reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model. The main 44.45-centimeter hole was drilled to a depth of 681.8 meters and cased with 33.97-centimeter casing to 671.7 meters. The hole diameter was then decreased to 31.12 centimeters, and the well was drilled to total depth of 894.9 meters. The completion string, set to the depth of 890.0 meters, consists of 14.13-centimeter stainless-steel casing hanging from 19.37-centimeter carbon-steel casing. The 14.13-centimeter stainless-steel casing has one continuous slotted interval open to the Topopah Spring aquifer. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 meters, sidewall core samples from 20 depth intervals, various geophysical logs, water quality (primarily tritium) measurements, and water level measurements. The well penetrated 894.9 meters of Tertiary volcanic rock, including two saturated welded-tuff aquifers. A fluid level measurement was obtained during open-hole geophysical well logging for the upper, Tiva Canyon, aquifer at the depth of 615.7 meters on June 19, 2009. The fluid level measured in the open hole on June 27, 2009,after the total depth was reached and the upper aquifer was cased off, was also at the depth of 615.7 meters. Preliminary field measurements indicated 1

  12. Lead fluxes and 206Pb/207Pb isotope ratios in rime and snow collected at remote mountain-top locations (Czech Republic, Central Europe): Patterns and sources

    Science.gov (United States)

    Cimova, Nikoleta; Novak, Martin; Chrastny, Vladislav; Curik, Jan; Veselovsky, Frantisek; Blaha, Vladimir; Prechova, Eva; Pasava, Jan; Houskova, Marie; Bohdalkova, Leona; Stepanova, Marketa; Mikova, Jitka; Krachler, Michael; Komarek, Arnost

    2016-10-01

    During three winter seasons (2009-2011), Pb concentrations were measured in precipitation at 10 high-elevation sites in the Czech Republic, close to the borders with Austria, Germany, Poland, and Slovakia. Soluble and insoluble Pb forms were quantified in snow (vertical deposition), and rime (horizontal deposition). The objective was to compare Pb input fluxes into ecosystems via vertical and horizontal deposition, and to identify the residual Pb pollution sources in an era of rapidly decreasing industrial pollution. Lead soluble in diluted HNO3 made up 96% of total Pb deposition, with the remaining 4% Pb bound mainly in silicates. Three times higher concentrations of soluble Pb in rime than in snow, and 2.5 times higher concentrations of insoluble Pb in rime than in snow were associated with slightly different Pb isotope ratios. On average, the 206Pb/207Pb ratios in rime were higher than those in snow. Higher mean 206Pb/207Pb ratios of insoluble Pb (1.175) than in soluble Pb (1.165) may indicate an increasing role of geogenic Pb in recent atmospheric deposition. A distinct reversal to more radiogenic 206Pb/207Pb ratios in snow and rime in 2010, compared to literature data from rain-fed Sphagnum peatlands (1800-2000 A.D.), documented a recent decrease in anthropogenic Pb in the atmosphere of Central Europe. Since the early 1980s, Pb concentrations in snow decreased 18 times in the rural south of the Czech Republic, but only twice in the industrial north of the Czech Republic. Isotope signatures indicated that Pb in today's atmospheric deposition is mainly derived from Mesozoic ores mined/processed in Poland and coal combustion in the Czech Republic and Poland.

  13. Structure-Activity Relationship of Synthetic Variants of the Milk-Derived Antimicrobial Peptide αs2-Casein f(183–207)

    Science.gov (United States)

    Begley, Máire; Clifford, Tanya; Deasy, Thérèse; Considine, Kiera; Hill, Colin

    2013-01-01

    Template-based studies on antimicrobial peptide (AMP) derivatives obtained through manipulation of the amino acid sequence are helpful to identify properties or residues that are important for biological activity. The present study sheds light on the importance of specific amino acids of the milk-derived αs2-casein f(183–207) peptide to its antibacterial activity against the food-borne pathogens Listeria monocytogenes and Cronobacter sakazakii. Trimming of the peptide revealed that residues at the C-terminal end of the peptide are important for activity. Removal of the last 5 amino acids at the C-terminal end and replacement of the Arg at position 23 of the peptide sequence by an Ala residue significantly decreased activity. These findings suggest that Arg23 is very important for optimal activity of the peptide. Substitution of the also positively charged Lys residues at positions 15 and 17 of the αs2-casein f(183–207) peptide also caused a significant reduction of the effectiveness against C. sakazakii, which points toward the importance of the positive charge of the peptide for its biological activity. Indeed, simultaneous replacement of various positively charged amino acids was linked to a loss of bactericidal activity. On the other hand, replacement of Pro residues at positions 14 and 20 resulted in a significantly increased antibacterial potency, and hydrophobic end tagging of αs2-casein f(193–203) and αs2-casein f(197–207) peptides with multiple Trp or Phe residues significantly increased their potency against L. monocytogenes. Finally, the effect of pH (4.5 to 7.4), temperature (4°C to 37°C), and addition of sodium and calcium salts (1% to 3%) on the activity of the 15-amino-acid αs2-casein f(193–207) peptide was also determined, and its biological activity was shown to be completely abolished in high-saline environments. PMID:23793637

  14. Immunophenotypes in 207 Pediatric Patients with ALL and Theirs Correlation with Cytogenetics and Clinical Features%207例儿童急性淋巴细胞白血病免疫表型与细胞遗传学及临床特征的相关性

    Institute of Scientific and Technical Information of China (English)

    佟海侠; 王秋实; 陆春伟; 王弘; 刘卓刚

    2011-01-01

    本研究检测207例儿童急性淋巴细胞白血病(ALL)患者的免疫表型,探讨其与细胞遗传学改变和临床特征的关系.应用流式细胞术及-组系列相关单克隆抗体对207例儿童ALL患者骨髓进行4色免疫表型分析,用染色体R显带技术对其中的146例进行核型分析.结果显示,207例儿童ALL患者中,11.6%为T-ALL,88.4%为B-ALL.42.5%ALL患者表达髓系抗原(MyAg),CD13是ALL中最常见的MyAg(31.4%).髓系抗原阳性率在T-ALL(41.7%)与B-ALL(42.6%)两组间未见统计学差异.可供核型分析的146例中核型异常者84例(57.5%).MyAg+ALL与MyAg-ALL患者临床和生物学特征分析表明,MyAg+ALL组白细胞计数高(>50×109/L)的患者比例及CD34+患者比例均高于MyAg-ALL组.结论:免疫表型对ALL的诊断与分型至关重要,免疫表型与患者的异常核型改变及临床特征关系密切.%The objective of this study was to investigate the immunophenotypic subtype profiles of 207 pediatric patients with acute lymphoblastic leukemia (ALL) and its correlation with cytogenetics and clinical features. 207 children with ALL were immunophenotyped by four color flow cytometry using a panel of monoclonal antibodies. 207 patients were enrolled in this study, out of which 146 cases were subjected to karyotype analysis by R-banding technology. The results showed that 11.6% out of 207 children with ALL were identified as T-ALL, 88.4% as B-ALL. Myeloid antigen (MyAg) expression was documented in 42.5% out of 207 cases analyzed and CD13 was the most commonly expressed MyAg (31.4%). No difference was observed in the expression of MyAg between the groups of patients with T-ALL (41.7%) and B-ALL (42.6%). Abnormal karyotypes were detected in 84 out of 146 (57.5%) children. The clinical and biological characteristics of ALL patients between MyAg + and MyAg- groups showed that higher percentage of patients with high WBC count ( >50 × 109/L) and higher CD34 positivity were found to be

  15. Ti02-K2Cr207协同体系测定染料.浓度实验条件的正交优化

    Institute of Scientific and Technical Information of China (English)

    张一平

    2013-01-01

    采用纳米Ti02-K2Cr207协同体系光催化氧化,分光光度法测定染料浓度.通过正交实验设计,研究pH值、TiO2用量、K2Cr2O,初始浓度、反应温度、紫外光照时间等因素对染料消解的影响.实验结果表明,各因素的影响程度从大到小依次为pH值〉K2Cr2O7浓度〉rriO:用量〉反应温度〉紫外光照时间;最佳消解条件为pH=1.0,TiO2用量为1.0g·L-1,K2Cr207初始浓度为10mmol·L-1,反应温度为90℃,紫外光照时间为12min.

  16. Performance Analysis of Wavelet Channel Coding in COST207-based Channel Models on Simulated Radio-over-Fiber Systems at the W-Band

    DEFF Research Database (Denmark)

    Cavalcante, Lucas Costa Pereira; Silveira, Luiz F. Q.; Rommel, Simon

    2016-01-01

    Millimeter wave communications based on photonic technologies have gained increased attention to provide optic fiber-like capacity in wireless environments. However, the new hybrid fiber-wireless channel represents new challenges in terms of signal transmission performance analysis. Traditionally......, such systems use diversity schemes in combination with digital signal processing (DSP) techniques to overcome effects such as fading and inter-symbol interference (ISI). Wavelet Channel Coding (WCC) has emerged as a technique to minimize the fading effects of wireless channels, which is a mayor challenge...... in systems operating in the millimeter wave regime. This work takes the WCC one step beyond by performance evaluation in terms of bit error probability, over time-varying, frequency-selective multipath Rayleigh fading channels. The adopted propagation model follows the COST207 norm, the main international...

  17. Physiological studies of environmental pollutants. Progress report, September 1, 1975--May 31, 1976. [/sup 210/Po, /sup 203/Pb, /sup 201/Tl, /sup 207/Bi, /sup 65/Zn

    Energy Technology Data Exchange (ETDEWEB)

    Lengemann, F W; Wentworth, R A

    1976-01-01

    In the past year we have looked at the transfer of some members of the actinide decay series into milk of goats. These were /sup 210/Po, /sup 203/Pb, /sup 201/Tl and /sup 207/Bi. All of these appeared in milk after oral ingestion but at levels less than 1 percent per liter. In addition we have looked at the transfer of /sup 65/Zn into milk of goats after oral and I.V. doses; the experiments are incomplete at this time. In controlled temperature studies it was found that 6.6 times as much radioiodine was secreted into milk when goats were at 33/sup 0/ as opposed to 5/sup 0/C. When radioiodine is put into the mammary gland the transfer from milk to body is rapid; more rapid than is the case for /sup 65/Zn. The analysis of these data indicate the need for a model capable of handling expansion of a compartment.

  18. Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa.

    Science.gov (United States)

    Braña, Alfredo F; Sarmiento-Vizcaíno, Aida; Osset, Miguel; Pérez-Victoria, Ignacio; Martín, Jesús; de Pedro, Nuria; de la Cruz, Mercedes; Díaz, Caridad; Vicente, Francisca; Reyes, Fernando; García, Luis A; Blanco, Gloria

    2017-05-19

    The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.

  19. Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa

    Science.gov (United States)

    Braña, Alfredo F.; Sarmiento-Vizcaíno, Aida; Osset, Miguel; Pérez-Victoria, Ignacio; Martín, Jesús; de Pedro, Nuria; de la Cruz, Mercedes; Díaz, Caridad; Vicente, Francisca; Reyes, Fernando; García, Luis A.; Blanco, Gloria

    2017-01-01

    The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus. PMID:28534807

  20. Excitation functions of residual nuclei production from 40–2600 MeV proton-irradiated 206,207,208,natPb and 209Bi

    Indian Academy of Sciences (India)

    Yu E Titarenko; V F Batyaev; V M Zhivun; V O Kudryashov; K A Lipatov; A V Ignatyuk; S G Mashnik

    2007-02-01

    The work is aimed at experimental determination of the independent and cumulative yields of radioactive residual nuclei produced in intermediate-energy proton-irradiated thin targets made of highly isotopic enriched and natural lead (206,207,208,natPb) and 209Bi. 5972 radioactive product nuclide yields have been measured in 55 thin targets induced by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6 and 2.6 GeV protons extracted from the ITEP U-10 proton synchrotron. The measured data have been compared with data obtained at other laboratories as well as with theoretical simulations by seven codes. We found that the predictive power of the tested codes is different but is satisfactory for most of the nuclides in the spallation region, though none of the codes agree well with the data in the whole mass region of product nuclides and all should be improved further.

  1. Análisis de parámetros influyentes en el diseño de columnas esbeltas según la NC 207:2003.

    Directory of Open Access Journals (Sweden)

    Limnavel Pestana Morejón

    2016-01-01

    Full Text Available Las Columnas son elementos sometidos a la acción combinada de momento y carga axial, su principal objetivo es sostener en altura los elementos que conforman los entrepisos y cubiertas. Estas son elementos lineares, donde una de sus dimensiones es muy superior a las restantes, trayendo consigo deformaciones de segundo orden producto al pandeo. Las normativas vigentes, en diferentes regiones, traducen este efecto en una amplificación de las solicitaciones, basados en diferentes métodos, con el fin de simplificar los cálculos, obteniendo según éstas, resultados muy veraces. No siendo el caso de la normativa vigente en Cuba, lo que ha llevado a proyectistas a recurrir a otras normativas o a programas computacionales. En la presente investigación se realiza un análisis de los parámetros influyentes en el diseño de columnas esbeltas según la NC 207:2003 “Requisitos generales para el diseño y construcción de estructuras de hormigón.

  2. Reproducibility of Retinol Binding Protein 4 and Omentin-1 Measurements over a Four Months Period: A Reliability Study in a Cohort of 207 Apparently Healthy Participants.

    Directory of Open Access Journals (Sweden)

    Clemens Wittenbecher

    Full Text Available The reliability of single time point measurements of the novel adipokines retinol-binding protein 4 and omentin-1 in the blood has not been evaluated in large samples yet. The present study aimed to assess the amount of biological variation of these two adipokines within individuals. The study sample comprised 207 participants (124 women and 83 men from Potsdam (Germany and surrounding areas, with an average age of 56.5 years (SD 4.2. Blood samples were collected from each participant twice, approximately four months apart. Using enzyme linked immunosorbent assays, the concentrations of retinol-binding protein 4 and omentin-1 were determined in EDTA plasma. As indicators of reliability, intraclass correlation coefficients (ICCs were calculated from the repeated biomarker measurements. The ICCs for repeated retinol-binding protein 4 and omentin-1 measurements were 0.77 (95% CI 0.71, 0.82 and 0.83 (95% CI 0.78, 0.87, respectively, indicating for both adipokines excellent reliability. ICCs were stable across strata according to sex, age, BMI, and blood pressure. Thus, for epidemiological studies it seems reasonable to rely on concentrations of retinol-binding protein 4 and omentin-1 in samples from a single time point if repeated measurements are not available.

  3. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-7, ER-20-8 #2, and ER-EC-11, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Greg Ruskauff

    2011-12-01

    This report analyzes the following data collected from ER-20-7, ER-20-8 No.2, and ER-EC-11 during WDT operations: (1) Chemical indicators of well development (Section 2.0); (2) Static hydraulic head (Section 3.0); (3) Radiochemistry and geochemistry (Section 4.0); (4) Drawdown observed at locations distal to the pumping well (Section 5.0); and (5) Drilling water production, flow logs, and temperature logs (Section 6.0). The new data are further considered with respect to existing data as to how they enhance or change interpretations of groundwater flow and transport, and an interim small-scale conceptual model is also developed and compared to Phase I concepts. The purpose of well development is to remove drilling fluids and drilling-associated fines from the formation adjacent to a well so samples reflecting ambient groundwater water quality can be collected, and to restore hydraulic properties near the well bore. Drilling fluids can contaminate environmental samples from the well, resulting in nonrepresentative measurements. Both drilling fluids and preexisting fines in the formation adjacent to the well can impede the flow of water from the formation to the well, creating artifacts in hydraulic response data measured in the well.

  4. A Summary of High-yielding Cultivation Demonstration of Promising Super Hybrid Rice Combination GD-1S/RB207%超级杂交稻苗头组合GD-1S/RB207高产示范小结

    Institute of Scientific and Technical Information of China (English)

    黄青宴; 何志华; 何志霞; 欧云芳

    2006-01-01

    GD-1S/RB207是国家杂交水稻工程技术研究中心选育的超级杂交稻苗头新组合,2004年在湖南汝城小面积示范,单产13.16 t/hm2,2005年示范7.1 hm2,验收产量12.59 t/hm2.介绍了2005年的示范表现和主要栽培措施,分析了产量没有达到13.5 t/hm2预期目标的原因,提出了该组合高产栽培示范应注意的技术措施.

  5. 49 CFR 571.207 - Standard No. 207; Seating systems.

    Science.gov (United States)

    2010-10-01

    ... minimize the possibility of their failure by forces acting on them as a result of vehicle impact. S2... than a school bus; a passenger seat on a school bus with a GVWR greater than 4,536 kilograms (10,000 pounds); and, a passenger seat on a school bus with a GVWR less than or equal to 4,536 kg...

  6. Adane 207-213.pmd

    African Journals Online (AJOL)

    Prof. Adipala Ekwamu

    viruses will inevitably increase in the process of variety ... plants using antibodies for six viruses or strains known to infect the crop in ... monoclonal antibodies specific to east African. (Kenyan) and West ..... Characterization of viruses of pepper ...

  7. Sports injury and illness incidence in the Rio de Janeiro 2016 Olympic Summer Games: A prospective study of 11274 athletes from 207 countries.

    Science.gov (United States)

    Soligard, Torbjørn; Steffen, Kathrin; Palmer, Debbie; Alonso, Juan Manuel; Bahr, Roald; Lopes, Alexandre Dias; Dvorak, Jiri; Grant, Marie-Elaine; Meeuwisse, Willem; Mountjoy, Margo; Pena Costa, Leonardo Oliveira; Salmina, Natalia; Budgett, Richard; Engebretsen, Lars

    2017-09-01

    To describe the pattern of injuries and illnesses sustained during the Games of the XXXI Olympiad, hosted by Rio de Janeiro from 5 to 21 August 2016. We recorded the daily incidence of athlete injuries and illnesses (1) through the reporting of all National Olympic Committee (NOC) medical teams and (2) in the polyclinic and medical venues by the Rio 2016 medical staff. In total, 11 274 athletes (5089 women, 45%; 6185 men, 55%) from 207 NOCs participated in the study. NOC and Rio 2016 medical staff reported 1101 injuries and 651 illnesses, equalling 9.8 injuries and 5.4 illnesses per 100 athletes over the 17-day period. Altogether, 8% of the athletes incurred at least one injury and 5% at least one illness. The injury incidence was highest in BMX cycling (38% of the athletes injured), boxing (30%), mountain bike cycling (24%), taekwondo (24%), water polo (19%) and rugby (19%), and lowest in canoe slalom, rowing, shooting, archery, swimming, golf and table tennis (0%-3%). Of the 1101 injuries recorded, 40% and 20% were estimated to lead to ≥1 and >7 days of absence from sport, respectively. Women suffered 40% more illnesses than men. Illness was generally less common than injury, with the highest incidence recorded in diving (12%), open-water marathon (12%), sailing (12%), canoe slalom (11%), equestrian (11%) and synchronised swimming (10%). Illnesses were also less severe; 18% were expected to result in time loss. Of the illnesses, 47% affected the respiratory system and 21% the gastrointestinal system. The anticipated problem of infections in the Rio Olympic Games did not materialise, as the proportion of athletes with infectious diseases mirrored that of recent Olympic Games (3%). Overall, 8% of the athletes incurred at least one injury during the Olympic Games, and 5% an illness, which is slightly lower than in the Olympic Summer Games of 2008 and 2012. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All

  8. micrOMEGAs 2.0.7: a program to calculate the relic density of dark matter in a generic model

    Science.gov (United States)

    Bélanger, G.; Boudjema, F.; Pukhov, A.; Semenov, A.

    2007-12-01

    micrOMEGAs2.0.7 is a code which calculates the relic density of a stable massive particle in an arbitrary model. The underlying assumption is that there is a conservation law like R-parity in supersymmetry which guarantees the stability of the lightest odd particle. The new physics model must be incorporated in the notation of CalcHEP, a package for the automatic generation of squared matrix elements. Once this is done, all annihilation and coannihilation channels are included automatically in any model. Cross-sections at v=0, relevant for indirect detection of dark matter, are also computed automatically. The package includes three sample models: the minimal supersymmetric standard model (MSSM), the MSSM with complex phases and the NMSSM. Extension to other models, including non supersymmetric models, is described. Program summaryTitle of program:micrOMEGAs2.0.7 Catalogue identifier:ADQR_v2_1 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADQR_v2_1.html Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Licensing provisions:Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.:216 529 No. of bytes in distributed program, including test data, etc.:1 848 816 Distribution format:tar.gz Programming language used:C and Fortran Computer:PC, Alpha, Mac, Sun Operating system:UNIX (Linux, OSF1, SunOS, Darwin, Cygwin) RAM:17 MB depending on the number of processes required Classification:1.9, 11.6 Catalogue identifier of previous version:ADQR_v2_0 Journal version of previous version:Comput. Phys. Comm. 176 (2007) 367 Does the new version supersede the previous version?:Yes Nature of problem:Calculation of the relic density of the lightest stable particle in a generic new model of particle physics. Solution method:In numerically solving the evolution equation for the density of dark matter, relativistic formulae for the thermal average are used. All tree

  9. Distribution of electron density in BaPb{sub 1-x}Bi{sub x}O{sub 3} evidenced by {sup 207}Pb and {sup 17}O NMR

    Energy Technology Data Exchange (ETDEWEB)

    Trokiner, Arlette; Piskunov, Yuri; Gerashenko, Alexander; Pogudin, Anton; Mikhalev, Konstantin; Yakubovsky, Andrey; Verkhovskii, Stanislav

    2004-08-01

    The inhomogeneous magnetic broadening of the {sup 17}O and {sup 207}Pb NMR spectra resulting from a distribution of the Knight shifts was studied in the metallic phase of BaPb{sub 1-x}Bi{sub x}O{sub 3} oxides (0{<=}x{<=}0.33). It was shown that Bi atoms, which are randomly incorporated in the parent BaPbO{sub 3}, give rise to an increased spin density of carriers within the two first cation shells. The percolative overlap of these areas is expected for superconducting compositions (x>0.1)

  10. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  11. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  12. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  13. The release of dissolved actinium to the ocean: A global comparison of different end-members

    Science.gov (United States)

    Geibert, W.; Charette, M.; Kim, G.; Moore, W.S.; Street, J.; Young, M.; Paytan, A.

    2008-01-01

    The measurement of short-lived 223Ra often involves a second measurement for supported activities, which represents 227Ac in the sample. Here we exploit this fact, presenting a set of 284 values on the oceanic distribution of 227Ac, which was collected when analyzing water samples for short-lived radium isotopes by the radium delayed coincidence counting system. The present work compiles 227Ac data from coastal regions all over the northern hemisphere, including values from ground water, from estuaries and lagoons, and from marine end-members. Deep-sea samples from a continental slope off Puerto Rico and from an active vent site near Hawaii complete the overview of 227Ac near its potential sources. The average 227Ac activities of nearshore marine end-members range from 0.4??dpm m- 3 at the Gulf of Mexico to 3.0??dpm m- 3 in the coastal waters of the Korean Strait. In analogy to 228Ra, we find the extension of adjacent shelf regions to play a substantial role for 227Ac activities, although less pronounced than for radium, due to its weaker shelf source. Based on previously published values, we calculate an open ocean 227Ac inventory of 1.35 * 1018??dpm 227Acex in the ocean, which corresponds to 37??moles, or 8.4??kg. This implies a flux of 127??dpm m-2 y- 1 from the deep-sea floor. For the shelf regions, we obtain a global inventory of 227Ac of 4.5 * 1015??dpm, which cannot be converted directly into a flux value, as the regional loss term of 227Ac to the open ocean would have to be included. Ac has so far been considered to behave similarly to Ra in the marine environment, with the exception of a strong Ac source in the deep-sea due to 231Paex. Here, we present evidence of geochemical differences between Ac, which is retained in a warm vent system, and Ra, which is readily released [Moore, W.S., Ussler, W. and Paull, C.K., 2008-this issue. Short-lived radium isotopes in the Hawaiian margin: Evidence for large fluid fluxes through the Puna Ridge. Marine Chemistry]. Another potential mechanism of producing deviations in 227Ac/228Ra and daughter isotope ratios from the expected production value of lithogenic material is observed at reducing environments, where enrichment in uranium may occur. The presented data here may serve as a reference for including 227Ac in circulation models, and the overview provides values for some end-members that contribute to the global Ac distribution. ?? 2007 Elsevier B.V. All rights reserved.

  14. Stable (206Pb, 207Pb, 208Pb) and radioactive (210Pb) lead isotopes in 1 year of growth of Sphagnum moss from four ombrotrophic bogs in southern Germany: Geochemical significance and environmental implications

    Science.gov (United States)

    Shotyk, William; Kempter, Heike; Krachler, Michael; Zaccone, Claudio

    2015-08-01

    The surfaces of Sphagnum carpets were marked with plastic mesh and 1 year later the production of plant matter was harvested in four ombrotrophic bogs from two regions of southern Germany: Upper Bavaria (Oberbayern, OB) and the Northern Black Forest (Nordschwarzwald, NBF). Radioactive, 210Pb was determined in solid samples using ultralow background gamma spectrometry while total Pb concentrations and stable isotopes (206Pb, 207Pb, 208Pb) were determined in acid digests using ICP-SMS. Up to 12 samples (40 × 40 cm) were collected per site, and 6-10 sites investigated per bog. The greatest variations within a given sampling site were in the range 212-532 Bq kg-1 for 210Pb activity, whereas 206Pb/207Pb and 208Pb/206Pb varied less than 1%. The median values of all parameters for the sites (6-10 per bog) were not significantly different. The median activities of 210Pb (Bq kg-1) in the mosses collected from the bogs in NBF (HO = 372 ± 56, n = 55; WI = 342 ± 58, n = 93) were slightly less from those in OB (GS = 394 ± 50, n = 55; KL = 425 ± 58, n = 24). However, the mosses in the NBF bogs exhibited much greater productivity (187-202 g m-2 a-1) compared to those of OB (71-91 g m-2 a-1), and this has a profound impact on the accumulation rates of 210Pb (Bq m-2 a-1), with the bogs in the NBF yielding fluxes (HO = 73 ± 30; WI = 65 ± 20) which are twice those of OB (GS = 29 ± 11; KL = 40 ± 13). Using the air concentrations of 210Pb measured at Schauinsland (SIL) in the southern Black Forest and average annual precipitation, the atmospheric fluxes of 210Pb at SIL (340 Bq m-2 a-1) exceeds the corresponding values obtained from the mosses by a factor of five, providing the first quantitative estimate of the net retention efficiency of 210Pb by Sphagnum. When the 210Pb activities of all moss samples are combined (n = 227), a significant decrease with increasing plant production rate is observed; in contrast, total Pb concentrations show the opposite trend. The contrasting

  15. Multijet-Produktion in der $e^+e^--$Annihilation von $\\sqrt{s}=$89 GeV bis 207 GeV Messung der starken Kopplung $\\alpha_s$ aus der Vierjetrate

    CERN Document Server

    Flagmeyer, Uwe

    2001-01-01

    Hadronic events from the data collected with the DELPHI detector at LEP within an energy range from 89 GeV to 207 GeV are selected and their jet rates are determined. The measurement of jet rates give no indication for an excess of multi jet events at high energies. The four jet rate is compared to next to leading order calculations. Studies on the influence of the renormalisation scale μ are performed confirming previous DELPHI results on optimised scales. Applying scale optimisation methods allows a precise measurement of the strong coupling αs from LEP1 data. The final result is obtained by the CAMBRIDGE algorithm: = 0:1175 ± 0:0010(exp:) ± 0:0017(hadr:) ± 0:0007(scale) . The comparison of αs as measured at the Z and at higher energies gives access to the energy dependence (running) of the strong coupling. The logarithmic energy slope, again obtained from Cambridge, is measured to be = 1:14 ± 0:25(stat:) ± 0:25(sys:) , while the QCD prediction for this quantity is 1.28. The results in are in good ...

  16. Geochemistry and 207Pb/ 206Pb zircon ages of granitoids from the southern portion of the Tamboril-Santa Quitéria granitic-migmatitic complex, Ceará Central Domain, Borborema Province (NE Brazil)

    Science.gov (United States)

    de Araujo, Carlos E. G.; Costa, Felipe G.; Pinéo, Tercyo R. G.; Cavalcante, José C.; Moura, Candido A. V.

    2012-02-01

    The Tamboril-Santa Quitéria Complex is an important Neoproterozoic granitic-migmatitic unit from the Ceará Central Domain that developed from ca. 650 to 610 Ma. In general the granitoids range in composition from diorite to granite with predominance (up to 85%) of granitic to monzogranitic composition with biotite as the main mafic AFM phase. Geochemical and 207Pb/ 206Pb evaporation zircon geochronology studies were applied in a group of these abundant monzogranitic rocks from the region of Novo Oriente in the southern portion of the Ceará Central Domain. In this area the granitoids are weakly peraluminous biotite granitoids and deformed biotite granitoids of high-K calc-alkaline and ferroan composition, which we interpreted as primary magmas (segregated diatexites) derived from the partial melting of crustal material. The close temporal relation of this magmatism with local eclogitic and regional high temperature metamorphism in Ceará Central Domain point out to an orogenic setting, arguably emplaced during the collisional stage. Subordinate coeval juvenile mantle incursions are also present. This crustally derived magmatism is the primary product of the continental thickening that resulted from the collision between the rocks represented by the Amazonian-West African craton (São Luiz cratonic fragment) to the northwest and the Paleoproterozoic-Archean basement of the Borborema Province to the southeast along the Transbrasiliano tectonic corridor.

  17. Rb-Sr and single - zircon grain 207Pb / 206Pb chronology of the Monesterio granodiorite and related migmatites. Evidence of a Late Cambrian melting event in the Ossa-Morena Zone, Iberian Massif

    Directory of Open Access Journals (Sweden)

    Bea, F.

    1999-04-01

    Full Text Available The Monesterio granodiorite, a small granodioritic body placed in a migmatitic complex in the SW of the Olivenza-Monesterio antiform, is a key plutonic body to understanding the relationships among the magmatism, metamorphism, and deformation in the Ossa-Morena Zone, SW Iberian Massif. We dated the granodiorite with the single zircon stepwise-evaporation 207Pb/206Pb method, and the related migmatization event with the Rb-Sr method on leucosomes. Our results indicate that the Monesterio granodiorite crystallised at 510 ± 7 Ma and its protolith had a component with Upper Proterozoic zircons with a minimum age of 1696 Ma. Leucosomes give a Rb-Sr age of 511 ± 40 Ma (MSWD =1,7 with initial 87Sr/86Sr =0.70914 ± 0.00048. The lower initial 87Sr/86Sr of the granodiorite and its calc-alkaline chemistry precludes it from having derived from the same protolith as the migmatites. The existence of different magmatic bodies in the Ossa-Morena Zone with ages clustering around 500-510 Ma reveals the existence of a significant melting event during the Late Cambrian that involved protoliths with very different geochemical and isotopic signatures.La granodiorita de Monesterio es un pequeño cuerpo emplazado en un complejo migmatítico en el SO del antiforme Olivenza-Monesterio, importante para entender las relaciones entre magmatismo, metamorfismo y deformación en la Zona de Ossa-Morena. Se ha datado la granodiorita por el método de evaporación secuencial de 207Pb/206Pb en cristal único de circón y los leucosomes de las migmatitas circundantes por el método Rb-Sr. Los datos indican una edad de cristalización de la granodiorita de 510 ± 4 Ma y un posible protolito Proterozoico Superior con una edad mínima de ∼1.700 Ma, obtenida a partir de núcleos heredados de los circones analizados. Los leucosomes dan una edad Rb-Sr de 511 ± 40 Ma, con una relación 87Sr/86Sr=0,70914 ± 0,00048. La relación inicial de 87Sr/86Sr en la granodiorita (

  18. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  19. 12 CFR 207.3 - CRA communications.

    Science.gov (United States)

    2010-01-01

    ... communication. A CRA communication is any of the following— (1) Any written or oral comment or testimony... contacts with a Federal banking agency. An oral or written communication with a Federal banking agency is... communication; (ii) More than 3 years before the parties entered into the agreement, in the case of any...

  20. 77 FR 207 - National Mentoring Month, 2012

    Science.gov (United States)

    2012-01-03

    ... with positive role models, foster leadership skills, and put them on the path to success in school and... with a mentor. Last January, we partnered with businesses across America to launch the Corporate... hereby proclaim January 2012 as National Mentoring Month. I call upon public officials, business and...

  1. 40 CFR 262.207 - Training.

    Science.gov (United States)

    2010-07-01

    ..., but not limited to: (1) Instruction by the professor or laboratory manager before or during an experiment; or (2) Formal classroom training; or (3) Electronic/written training; or (4) On-the-job...

  2. 50 CFR 223.207 - Approved TEDs.

    Science.gov (United States)

    2010-10-01

    ... than 4 inches (10.2 cm) from the frame and may not extend past the frame. A horizontal brace bar to... the TED frame must not exceed 4 inches (10.2 cm). (5) Direction of bars. The deflector bars must run... bottom bars and two of the top bars, including the frame, may run from side to side of the TED....

  3. 14 CFR 67.207 - Mental.

    Science.gov (United States)

    2010-01-01

    ... person is dependent on a substance, other than tobacco or ordinary xanthine-containing (e.g., caffeine... concentration, or a refusal to submit to a drug or alcohol test required by the U.S. Department...

  4. 207-A retention basins system design description

    Energy Technology Data Exchange (ETDEWEB)

    Wahlquist, R.A.

    1994-09-29

    The 242-A Evaporator is a waste treatment facility designed to reduce liquid waste volumes currently stored in the Hanford Area double shell Waste Storage Tanks. The evaporator uses evaporative concentration to achieve this volume reduction, returning the concentrated slurry to the double-shell tanks for storage. The process effluent is transferred to various retention/treatment facilities for eventual release to the environment. The process utilizes an evaporator vessel and various supporting systems for heating, evaporating, and condensing low-heat-generating liquid waste produced it the Hanford Site. The process reduces the total volume of the liquid waste requiring storage in a double shell tank, making it more manageable for current storage as well as for future treatment and disposal. The main components of the 242-A Evaporator are the Reboiler, Vapor-Liquid Separator, Recirculation Pump and Pump Loop, Slurry System, Condenser System, Steam Jet Vacuum System, Condensate Collection Tank, and Ion Exchange System.

  5. 14 CFR 417.207 - Trajectory analysis.

    Science.gov (United States)

    2010-01-01

    ... potential three-sigma trajectory dispersions about the nominal trajectory. (2) A fuel exhaustion trajectory...) Trajectory model. A final trajectory analysis must use a six-degree of freedom trajectory model to...

  6. 7 CFR 62.207 - Official assessment.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) LIVESTOCK, MEAT, AND OTHER AGRICULTURAL COMMODITIES (QUALITY SYSTEMS VERIFICATION PROGRAMS) Quality Systems Verification...

  7. 20.7 Peripheral nerve disease

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930394 A1—10 year follow—up study of 82cases of methamidophos induced delayedpolyneuropathy.Z1HENG Rongyuan (郑荣远),etal.Neurol Dept,Wenzhou Med Coll.325000.Chin J Industr Hyg & Occupat Dis 1992;10(6):344—347.A1—10 year follow—up study of 82 cases ofmethamidophos induced delayed polyneuropathywas reported.82 cases were classified into threetypes:motor (36.6%),sensory—motor (61%)and Guillain-Barre syndrome (2.4%).As awhole,the sensory disturbances disappearedwithin 2—3 months;the autonomic nerve func-tional disorder vanished within 3—6 months;

  8. 30 CFR 75.207 - Pillar recovery.

    Science.gov (United States)

    2010-07-01

    ... practicable; and (ii) Across each opening leading into an area where full or partial pillar extraction has... conducted in the following manner, unless otherwise specified in the roof control plan: (a) Full and partial... the roadway shall not exceed 14 feet. (d) During open-end pillar extraction, at least 2 rows...

  9. 43 CFR 17.207 - Notification.

    Science.gov (United States)

    2010-10-01

    ... vision or hearing, the mentally retarded, the learning disabled, and any other disability that impairs.... (a) A recipient that employs fifteen or more people shall take appropriate initial and continuing...

  10. 21 CFR 207.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... otherwise provided. (2) Advertising and labeling include the promotional material described in § 202.1(l) (1... to the ultimate consumer. (9) Representative sampling of advertisements means typical advertising... promotional claims used for the drug, e.g., if more than one medical journal advertisement is used but...

  11. GPCR Interaction: 207 [GRIPDB[Archive

    Lifescience Database Archive (English)

    Full Text Available Information about hetero oligomer between Glucagon-like peptide receptor type 2 (GLP2) and secr...etin (SecR), and interfaces of GLP2 B Glucagon-like peptide Type 2 GLP2 C Secretin ... SecR Experi

  12. 19 CFR 207.100 - Sanctions.

    Science.gov (United States)

    2010-04-01

    ... the Commission; (5) In the case of an attorney, accountant, or other professional, referral of the facts underlying the prohibited act to the ethics panel or other disciplinary body of the appropriate professional association or licensing authority; (6) When appropriate, referral of the facts underlying...

  13. 24 CFR 1003.207 - Ineligible activities.

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT COMMUNITY DEVELOPMENT BLOCK GRANTS FOR INDIAN TRIBES AND ALASKA NATIVE VILLAGES Eligible... under the provisions of §§ 1003.201 through 1003.206 is ineligible to be assisted with ICDBG funds. This... following activities may not be assisted with ICDBG funds: (1) Buildings or portions thereof used for the...

  14. 40 CFR 20.7 - General policies.

    Science.gov (United States)

    2010-07-01

    ... and abatement of water pollution are: To enhance the quality and value of our water resources; to... condition of surface and underground waters; and to conserve such waters for public water supplies, propagation of fish and aquatic life and wildlife, recreational purposes, and agricultural, industrial, and...

  15. Reference: 207 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available generated Arabidopsis transgenic lines showing various albino patterns caused by IspH transgene-induced gen...he late dark period (4-6 h). The expression patterns of DXS and IspG are similar to that of IspH, indicating

  16. BDML Metadata: 207 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available Ce_KK_P002 BDML file for quantitative information about nuclear division dynamics o...bic.riken.jp/data/source/Ce_KK_P002/RNAi_T12D8.7_070220_01.zip http://ssbd.qbic.riken.jp/data/bdml.../Ce_KK_P002/RNAi_T12D8.7_070220_01.bdml0.18.xml http://ssbd.qbic.riken.jp/data/pdpml/Ce_KK_P002.pdpml0.06.xml

  17. 7 CFR 1786.207 - Prepayment premium.

    Science.gov (United States)

    2010-01-01

    ... discounted at a rate equal to the then current cost of funds to the Department of the Treasury for... interest rate on the loan were equal to the then current cost of funds to the Department of the...

  18. 47 CFR 20.7 - Mobile services.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES COMMERCIAL MOBILE RADIO... meeting the definition of commercial mobile radio service in § 20.3, such as the resale of commercial... chapter), including fixed operations that support the mobile systems, but excluding Rural Radio...

  19. 14 CFR 25.207 - Stall warning.

    Science.gov (United States)

    2010-01-01

    ... sufficient margin to prevent inadvertent stalling with the flaps and landing gear in any normal position must... the pilot to prevent stalling (as defined in § 25.201(d)) when the pilot starts a recovery maneuver... non-icing and icing conditions to allow the pilot to prevent stalling when the pilot starts a...

  20. 30 CFR 20.7 - Specific requirements.

    Science.gov (United States)

    2010-07-01

    ...-contained and not so readily portable as the first class. (a) Class 1. Class 1 includes hand lamps, signal... dry cells. (b) Class 2. Class 2 includes lamps such as the pneumatic-electric types and large...

  1. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  2. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  3. Comment on "207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the Central Anatolian crust, Turkey" - Boztug, D., Tichomirowa, M. & Bombach, K., 2007, JAES 31, 71-86

    Science.gov (United States)

    Göncüoglu, M. Cemal

    A continent-oceanic island arc collision model was proposed as a new geodynamic scenario for the evolution of the Cretaceous Central Anatolian granitoids in the Central Anatolian crystalline complex (CACC) by Boztug et al. (2007b) [Boztug, D., Tichomirowa, M., Bombach, K., 2007b. 207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the central Anatolian crust, Turkey. Journal of Asian Earth Sciences 31, 71-86]. The key aspects of this model include an intra-oceanic subduction in the Neotethyan Izmir-Ankara Ocean, formation of an island arc and its subsequent collision with the northern margin of the Tauride-Anatolide Platform. The identical scenario was initially proposed by Göncüoglu et al. (1992) [Göncüoglu, M.C., Erler, A., Toprak, V., Yalınız, K., Olgun, E., Rojay, B., 1992. Geology of the western Central Anatolian Massif, Part II: Central Areas. TPAO Report No: 3155, 76 p] . Moreover, the weighted mean values of the reported 207Pb-206Pb single-zircon evaporation ages by Boztug et al. (2007b) [Boztug, D., Tichomirowa, M., Bombach, K., 2007b. 207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the central Anatolian crust: Turkey. Journal of Asian Earth Sciences 31, 71-86] from A-type granitoids in the CACC seem to be miscalculated and contrast with the field data.

  4. U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar geochronology of granite-greenstone terrains of Gaviao Block: implications for the Proterozoic and Archean evolution of Sao Francisco Craton, Brazil; Geocronologia U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar dos terrenos granito-greenstone do Bloco do Gaviao: implicacoes para a evolucao arqueana e proterozoica do craton do Sao Francisco, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Leal, Luiz Rogerio Bastos

    1998-07-01

    The Gaviao Block (GB) in the northern portion of the Sao Francisco Craton-Northeast of Brazil, constitutes one of the oldest Archean fragments of the South American Platform Archean crust. GB underwent several events of juvenile accretion and reworking of continental crust along its evolutionary history, notably between the Archean and the Paleoproterozoic. {sup 207}Pb/{sup 206}Pb isotopic analyses were carried out in two zircons populations from strongly migmatized TTG terranes found in the proximity of Brumado: the first population (7 crystals) is taken as representative of the crystallization period of the TTG terranes at 3300 {+-} 45 Ma; the second (2 crystals) represents the age of the first even of metamorphism/migmatization at 2910 {+-} 10 Ma. {sup 207} Pb/{sup 206} Pb analyses in zircons from an outcrop of non-migmatized TTG in the area yielded a 3202 {+-} 15 Ma age (4 crystals), interpreted to be the crystallization period of the gneiss protolith. Sm/Nd analyses on the TTG rocks of the Brumado region yielded T{sub DM} model ages varying between 3.26 and 3.36 Ga and {epsilon}{sub Nd}{sup (t)} between -3.5 and +0.7. These data suggest the occurrence of juvenile accretions to the continental crust during the Archean, with differential involvement of crustal materials. The geochemical data of rare earth elements corresponding to the TTG terranes revealed moderate LRRE contents (La{sub N}=83,5), low HREE contents (La{sub N}=2,5) and a fairly fractionated pattern (La/Yb){sub N}=34, besides lack of negative Eu anomaly, showing that these rocks have similar compositions to those TTG terranes of cratonic continents, as well as some Archean rocks from CSF (e.g. Sete Voltas, Boa Vista). Finally, the youngest ages present in GB rocks (ca. 1.2-0.45 Ga) represent the role played by tectono thermal events, which produced partial or total rejuvenation of the Rb/Sr and K/Ar isotopic systems during the Espinhaco and Brasiliano cycles. In particular, K/Ar ages illustrate the

  5. 农村留守中小学生问题行为及家庭影响因素分析%Study of problem behavior and their families influencing factors of 207 rural left-behind primary and secondary students

    Institute of Scientific and Technical Information of China (English)

    张雪琴; 龙永梅; 张哲; 何兰英; 邱晓娜; 王静进

    2011-01-01

    目的 了解农村留守中小学生的问题行为及家庭影响因素,为特殊群体的身心健康教育提供决策依据.方法 采用Conners儿童行为量表及白编家庭情况调查问卷,对207名小学和初中的留守学生进行调查.结果 留守中小学生的问题行为检出率为15.46%,其中品行问题检出率最高;留守中小学生的问题行为较非留守中小学生严重,其品行问题、多动、不注意-被动得分高于非留守中小学生;抚养人类别、文化程度及父母外出时间是影响留守中小学生的重要因素.结论 正常、温暖、有序的家庭环境是孩子健康成长的保证.农村留守中小学生的父母、抚养人、学校及社会应群策群力,减少中小学生行为问题的发生.%Objective To understand the problem behaviors and the influencing factors from their families of rural left-behind primary and secondary students, and to provide evidence for their mental health education. Methods Conners Child Behavior Scale, and self-compiled questionnaires to the families were used to investigate 207 elementary and junior high school students. Results The problem behavior detection rate of left-behind primary and secondary students was 15.46%, the highest detection rate were behavioral problems; the behavioral problems of home-left primary and secondary students were worse than non-left-behind students. Score of conduct problems, hyperactivity, no attention-passive were higher than score of non-left-behind students. Class and educational level of caregivers and how long their parents go out was an important affecting factor. Conclusion Normal ,warm, orderly family environment is to ensure the healthy growth of each child. Parents, caregivers, schools and society should work together to reduce home-left primary and secondary students' behavior problems.

  6. Discussion of 'Geomorphology, internal structure, and successive development of a glacier foreland in the semiarid Chilean Andes (Cerro Tapado, upper Elqui Valley, 30°08‧ S, 69°55‧ W.)', by S. Monnier, C. Kinnard, A. Surazakov and W. Bossy, Geomorphology 207 (2014), 126-140

    Science.gov (United States)

    Nobes, David C.

    2015-12-01

    Recently, Monnier et al. (2014, Geomorphology 207, 126-140) suggested that diffraction events with air-wave velocities along profile CD were caused by an air-filled void at depth within one of the glaciers of the Cerro Tapado, Chile. This is not physically possible. The velocity at which radar travels to and from the scattering feature that causes a diffraction is at the velocity that surrounds and overlies the scatterer. Thus, their air-wave velocity features are on the surface of the glacier, not at depth. Their three-layer model for profile CD, therefore, is more appropriately a two-layer model, with a lower density layer, with more air and debris, overlying a denser layer, likely corresponding to the firn-ice transition. In addition, they carried out common mid-point (CMP) velocity profiles. While it is encouraging that they have made such an attempt, the results will be affected significantly by the surface and subsurface topography, truncated beds, unconformities, etc., because CMP profiles inherently assume flat-lying surface and subsurface boundaries. The CMP results, while useful, must therefore be treated with caution and assumed to be highly inaccurate and only be used as general guides to vertical velocity variations.

  7. Residual nuclide formation in 206,207,208,nat-Pb and 209-Bi induced by 0.04-2.6 GeV Protons as well as in 56-Fe induced by 0.3-2.6 GeV Protons

    CERN Document Server

    Titarenko, Yu E; Titarenko, A Yu; Butko, M A; Pavlov, K V; Tikhonov, R S; Florya, S N; Mashnik, S G; Ignatyuk, A V; Gudowski, W

    2007-01-01

    5972 independent and cumulative yields of radioactive residuals nuclei have been measured in 55 thin 206,207,208,nat-Pb and 209-Bi targets irradiated by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6, and 2.6 GeV protons. Besides, 219 yields have been measured in 0.3, 0.5, 0.75, 1.0, 1.5, and 2.6 GeV proton-irradiated 56-Fe target. The protons were extracted from the ITEP U-10 synchrotron. The measured data are compared with experimental results obtained elsewhere and with theoretical calculations by LAHET, MCNPX, CEM03, LAQGSM03, CASCADE, CASCADO, and LAHETO codes. The predictive power was found to be different for each of the codes tested, but was satisfactory on the whole in the case of spallation products. At the same time, none of the codes can de-scribe well the product yields throughout the whole product mass range, and all codes must be further improved.

  8. 38 CFR 3.207 - Void or annulled marriage.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Void or annulled marriage... Void or annulled marriage. Proof that a marriage was void or has been annulled should consist of: (a... marriage void, together with such other evidence as may be required for a determination. (b) Annulled....

  9. 48 CFR 415.207 - Handling proposals and information.

    Science.gov (United States)

    2010-10-01

    ... Proposals RFP Offeror 1. To the best of my knowledge and belief, no conflict of interest exists that may... purposes of the Freedom of Information Act (5 U.S.C. 552). (d) The contracting officer shall attach a cover...

  10. Dicty_cDB: VFO207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 598422. 1197 0.0 1 ( BD092935 ) Methods and compositions for synthesis of long ch... 1197 0.0 1 ( BD082645 ) Methods and composition...s for synthesis of long ch... 1197 0.0 1 ( BD082630 ) Methods and composition

  11. 207 EFFECTS OF HOT AND COLD WATER PRE- TREATMENTS ...

    African Journals Online (AJOL)

    JOURNAL OF RESEARCH IN FORESTRY, WILDLIFE AND ENVIRONMENT. VOLUME 2 ... dormancy, these methods include hot water. (FAO .... ASSET Journal Series A, 2: 29-36. FAO 1990. Arabic Gum, FAO Food and. Nutrition. Food and ...

  12. 40 CFR 6.207 - Environmental impact statements.

    Science.gov (United States)

    2010-07-01

    ... as wetlands, significant agricultural lands, aquifer recharge zones, coastal zones, barrier islands... with a population greater than 100,000. (ii) Expansions of existing wastewater treatment facilities... distribution of population including altering the character of existing residential areas. (4) An EIS must be...

  13. 14 CFR 125.207 - Emergency equipment requirements.

    Science.gov (United States)

    2010-01-01

    ... equipment: (1) One approved first aid kit for treatment of injuries likely to occur in flight or in a minor... crewmembers. (2) A crash axe carried so as to be accessible to the crew but inaccessible to passengers during...

  14. Dicty_cDB: SHI207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available f query: 148 length of database: 80,480,566 effective HSP length: 17 effective length of query: 131 effective... length of database: 78,821,179 effective search space: 10325574449 effective se...er of sequences better than 10.0: 0 length of query: 148 length of database: 61,296,806,322 effective HSP length: 22 effective... length of query: 126 effective length of database: 60,048,944,916 effective search space: 7566167059416 effective

  15. 48 CFR 5.207 - Preparation and transmittal of synopses.

    Science.gov (United States)

    2010-10-01

    ... Architect-Engineer projects and other projects for which the supply or service codes are insufficient... Agreements, 52.225-23, Required Use of American Iron, Steel, and Manufactured Goods—Buy American...

  16. 33 CFR 110.207 - Cleveland Harbor, Ohio.

    Science.gov (United States)

    2010-07-01

    ... opposite Cleveland East Entrance Light to a due north line passing through the flashing white light on the... Breakwater from Cleveland West Breakwater Light. (2) East anchorage. The southeasterly portion of the East... and distances from Cleveland East Pierhead Light: 38°30′, 2,050 feet; 68°, 2,050 feet; 57°, 7,050...

  17. 47 CFR 90.207 - Types of emissions.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND... telecommand. E—Voice. N—No transmitted information. W—Combination of the above. (b) Authorizations to use A3E, F3E, or G3E emission also include the use of emissions for tone signals or signaling devices...

  18. Dicty_cDB: VHQ207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available date 2002.10.25 Translated Amino Acid sequence fkriyfggrsgegfhnngihlwvsrs*glg*lslirllghwieseggfntsdfigrkgsg ...istnvcrrsyakc*ry*iwcklwfq*n *iliastsrw*fkm*i*itrintsfrwcssc*kk Frame B: fkriyfggrsgegfhnngihlwvsrs*glg*lslirllghwiese

  19. Processing and Testing Re2Si207 Matrix Composites (Preprint)

    Science.gov (United States)

    2012-07-01

    using the Archimedes method. 2.3. Indentation and Characterization The hardnesses of the sintered pellets were measured by Vickers indentation at...J. Mechanical Properties and Atomistic Deformation Mechanism of g-Y2Si2O7 from First- Principles Investigations. Acta mat. 55, 6019-6026 (2007). 10

  20. 7 CFR 1280.207 - Term of office.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Lamb Promotion, Research, and...

  1. 40 CFR 180.207 - Trifluralin; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... Alfalfa, forage 3.0 Alfalfa, hay 2.0 Almond, hulls 0.05 Asparagus 0.05 Barley, grain 0.05 Barley, hay 0.05 Barley, straw 0.05 Bean, mung, sprouts 2.0 Carrot, roots 1.0 Celery 0.05 Corn, field, forage 0.05 Corn..., group 8 0.05 Vegetable, leaves of root and tuber, group 2 0.05 Vegetable, legume, group 6 0.05...

  2. 49 CFR 212.207 - Signal and train control inspector.

    Science.gov (United States)

    2010-10-01

    ... Signal Systems (49 CFR part 236), to make reports of those inspections, and to recommend the institution... knowledge of signal and train control systems, maintenance practices, test and inspection techniques; (2... standards accepted in the industry; and (ii) The Rules, Standards and Instructions for Railroad...

  3. 47 CFR 73.207 - Minimum distance separation between stations.

    Science.gov (United States)

    2010-10-01

    ... kW ERP and 100 meters antenna HAAT (or equivalent lower ERP and higher antenna HAAT based on a class... which have been notified internationally as Class A are limited to a maximum of 3.0 kW ERP at 100 meters... internationally as Class AA are limited to a maximum of 6.0 kW ERP at 100 meters HAAT, or the equivalent; (iii) U...

  4. 48 CFR 207.170-3 - Policy and procedures.

    Science.gov (United States)

    2010-10-01

    ... $6 million unless the acquisition strategy includes— (1) The results of market research; (2... justified. (i) Market research may indicate that consolidation of contract requirements is necessary and justified if the benefits of the acquisition strategy substantially exceed the benefits of each of...

  5. 33 CFR 135.207 - Insurance as evidence.

    Science.gov (United States)

    2010-07-01

    ... of the policy coverage, by any person for claims under the Act against the owner or operator; and (2...) Confirmation of insurance may be accepted from an insurance broker that is acceptable to the Fund...

  6. 37 CFR 2.207 - Methods of payment.

    Science.gov (United States)

    2010-07-01

    ... cancel the credit until collection is made. Checks and money orders must be made payable to the Director... by mail will be at the risk of the sender, and letters containing money should be registered with the... credit card, except for replenishing a deposit account. Payment of a fee by credit card must specify...

  7. MO-AB-207-04: ACR Update in Mammography

    Energy Technology Data Exchange (ETDEWEB)

    Berns, E. [University of Colorado Health Science (United States)

    2015-06-15

    A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

  8. Dicty_cDB: SSK207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ce *sklwfipl*lq*ilyyg*wlssmfilkwycticmwspnlcsttimckg*klstmcfstk trq*lw*qil***tsmc*krtrl*mysktsyl*DQKMRTSQVCI...sstcrstt--- Frame C: *sklwfipl*lq*ilyyg*wlssmfilkwycticmwspnlcsttimckg*klstmcfstk

  9. 29 CFR 825.207 - Substitution of paid leave.

    Science.gov (United States)

    2010-07-01

    ... leave supplement workers' compensation benefits, such as in the case where workers' compensation only.... As of the date workers' compensation benefits cease, the substitution provision becomes applicable... leave pursuant to a disability benefit plan is not unpaid, the provision for substitution of the...

  10. 33 CFR 207.750 - Puget Sound Area, Wash.

    Science.gov (United States)

    2010-07-01

    ... vessel against the currents to be met within the lock chamber. The use of wire rope for tie-up by vessels... written permission to pass is provided by the District Engineer. Sufficient written data and drawings... securely fastened to the hull of the vessel to prevent their rolling overboard into the lock chamber and...

  11. 5 CFR 843.207 - Agent of next of kin.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-DEATH BENEFITS AND EMPLOYEE REFUNDS One-time Payments § 843... the unexpended balance or accrued benefit may designate the one who made the claim to act as...

  12. Dicty_cDB: VHM207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lignments: (bits) Value AC116963_42( AC116963 |pid:none) Dictyostelium discoideum chromoso...... 167 2e-40 AC117075_64( AC117075 |pid:none) Dictyostelium discoideum chromoso... 155 1e-36 AC116...960_61( AC116960 |pid:none) Dictyostelium discoideum chromoso... 154 1e-36 AC116982_41( AC116982 |pid:none) ...Dictyostelium discoideum chromoso... 152 9e-36 AC117081_43( AC117081 |pid:none) D...ictyostelium discoideum chromoso... 144 3e-33 AC116956_34( AC116956 |pid:none) Dictyostelium discoideum chromoso...

  13. MO-AB-207-02: ACR Update in MR

    Energy Technology Data Exchange (ETDEWEB)

    Price, R. [Vanderbilt Medical Center (United States)

    2015-06-15

    A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

  14. MO-AB-207-01: ACR Update in CT

    Energy Technology Data Exchange (ETDEWEB)

    McNitt-Gray, M. [UCLA School of Medicine (United States)

    2015-06-15

    A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

  15. TU-EF-207-00: Advances in Breast Imaging

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  16. 18 CFR 157.207 - General reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL... specified in § 157.217(b); (g) For each change in customer name authorized under § 157.218, the...

  17. Dicty_cDB: SLA207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available S 379 of Saccharomyces exiguus. 101 1e-46 4 AL408145 |AL408145.1 T7 end of clone AV0AA006G11 of library AV0A...A from strain CBS 379 of Saccharomyces exiguus. 101 5e-46 4 AZ932350 |AZ932350.1

  18. Viis minutit võitu 207 miljoni eest / Hannes Luts

    Index Scriptorium Estoniae

    Luts, Hannes

    2011-01-01

    Summaga, mis kulub Kose-Mäo teelõigu rajamiseks, saaks rekonstrueerida enamiku Tallinna-Tartu raudteest kiirusele 160 km/h, parem rongiliiklus võib oluliselt vähendada sama suuna maanteeliiklust. Teedemaksu kehtestamisest

  19. 21 CFR 207.10 - Exemptions for establishments.

    Science.gov (United States)

    2010-04-01

    ...) DRUGS: GENERAL REGISTRATION OF PRODUCERS OF DRUGS AND LISTING OF DRUGS IN COMMERCIAL DISTRIBUTION... regulating dispensing of prescription drugs and that do not manufacture or process drugs for sale other than... drugs at retail. The supplying of prescription drugs by these pharmacies to a practitioner licensed...

  20. WE-A-207-01: Memorial Lecturer

    Energy Technology Data Exchange (ETDEWEB)

    Muller-Runkel, R [St. Margaret Mercy Healthcare Centers, Hammond, IN (United States)

    2015-06-15

    The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed.

  1. 33 CFR 207.460 - Fox River, Wis.

    Science.gov (United States)

    2010-07-01

    ... operating schedules at least 10 days in advance of such dates. (2) Authority of lockmaster. The movement of... shall be raced or crowded alongside another vessel, or be moved at such speed as will cause...

  2. RCT: Module 2.07, Respiratory Protection, Course 8773

    Energy Technology Data Exchange (ETDEWEB)

    Hillmer, Kurt T. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-10

    Internal dosimetry controls require the use of engineering controls to prevent the internal deposition of radioactive and nonradiological contaminants. However, when engineering and administrative controls are not available or feasible, respiratory protection may be necessary. The radiation control technician (RCT) should know and apply the considerations used in determining the respiratory protection equipment that is most appropriate for the job. The inappropriate use of or the use of the wrong respiratory protection equipment may result in undesirable health effects. This course will prepare the student with the skills necessary for RCT qualification by passing quizzes, tests, and the RCT Comprehensive Phase 1, Unit 2 Examination (TEST 27566) and will provide in-the-field skills.

  3. Dicty_cDB: VFA207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 0.005 1 AB022770 |AB022770.1 Human rotavirus mRNA for NSP2, complete cds. 52 0.005 1 X57944 |X57944.1 Human rotavirus...clone RP11-291E21 from 4, complete sequence. 42 0.011 5 Z21640 |Z21640.1 Bovine rotavirus (Strain RF) mRNA f

  4. 24 CFR 941.207 - Displacement, relocation, and acquisition.

    Science.gov (United States)

    2010-04-01

    ...) The terms and conditions under which the tenant may lease and occupy a suitable, decent, safe, and... CFR part 24, subpart B. With respect to the Turnkey method of development (see 24 CFR 941.102(b)), 49... shall be issued a notice offering the tenant the opportunity to enter into a lease to continue in...

  5. Translating cultural transition in Kgebetli Moele’s Room 207

    Directory of Open Access Journals (Sweden)

    S.S. Ibinga

    2010-07-01

    Full Text Available This article deals with the issue of cultural translation in a postapartheid text through the analysis of language, setting and discourse to highlight cultural transition in a society where socio-political mutations elicit new literary codes and symbols. The discussion is developed around concepts such as gender and ethnic identity or citizenship in a geographical environment where multi- and transcultural identities are endlessly being contested. The concept of translation is explored to show how Moele’s text represents cultural transition within a postapartheid urban context by analysing the authorial transposition of everyday experience into the textual fabric. The article also examines how the narrative voice negotiates across the current multicultural divide in order to highlight cultural change both in South African literature and in society as a whole. This article addresses in the discussion the controversial debate raised by Michael Titlestad’s (2007 review of the book published in the “Sunday times” on 25 March in which the critic evinces a negative reception of the book. This is used as a point of departure in order to explore a wide range of possibilities that fiction can offer by means of textual representation of the daily experience of black people in a postapartheid urban context.

  6. [Comorbidity in 207 cannabis users in a specific outpatient setting].

    Science.gov (United States)

    Guillem, E; Arbabzadeh-Bouchez, S; Vorspan, F; Bellivier, F

    2015-06-01

    Health care seeking for a problematic use of cannabis is in progress in France. The aim is to assess the addictive and psychiatric comorbidity in cannabis users seen in the specific setting at the Lariboisière hospital. Two hundred and seven cannabis users were included from January 2004 to December 2009. Twelve-month and lifetime diagnosis of abuse and dependence (cannabis, alcohol, cocaine/crack) (DSM-IV), current and lifetime mood disorders, anxiety disorders, eating disorders and psychotic disorders were assessed (Mini-International Neuropsychiatric Interview). Logistic regression analyses identified adjusted odds ratios associated with the gender and the health care seeking (P=0.01). One hundred and forty-seven men (71%) and 60 women (29%), 29.3±8.6 years (15.2-51.6 years). Most of the outpatients ask for health care themselves (59.7%), whereas 19.4% are asked to seek health care by relatives (19.4%) or because of an academic, health or justice injunction (20.4%). In total, 49.3% of the outpatients are single, 35.7% are cohabitating, 9.3% are married and 6.3% are separated/divorced. About 20.4% of the outpatients are students, 35.7% have a professional activity, 19% are jobless, 2.4% are impaired, 0.5% are retired, at home and 12.1% do not have an official income. Twelve-month and lifetime prevalence of abuse/dependence are: cannabis (10.1/82.1% and 8.7/88.4%), alcohol (9.7/8.7% and 19.3/18.8%), cocaine/crack (2.4/3.4% and 4.8/11.6%). The mean duration of cannabis dependence for the current dependent users is 8.4±5.8 years. The mean number of "joints" during the last 6 months is 6±4.3, the mean amount of cannabis per week is 12.5±11.3g. About 51.3% of the dependent users report externalized and/or internalized disorders at school during childhood and adolescence. In total, 19.4% of the dependent users have a suicide attempt history and 18.9% have a psychiatric hospitalisation history, more frequently women (Pdepressive disorder (MDD) (29.1% and 57.1%); current dysthymia (20.3%); hypomania (1.9 and 6.7%); mania (2.9 and 12.8%). Females have more frequently than males current and lifetime MDD (Pcannabis abuse OR=1.1 [1.04-1.17] (P=0.002). Adjusted odds ratios associated with personal health care seeking compared to a non personal motivated health care seeking are the numbers of criteria of 12-month cannabis dependence OR=1.26 [1.06-1.51] (P=0.009) and age OR=1.07 [1.03-1.12] (P=0.002). Our survey confirms the high mood and anxiety disorders comorbidity in cannabis dependent users seen in a specific setting and underlines the need to evaluate those disorders. Copyright © 2014 L’Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.

  7. 48 CFR 207.106 - Additional requirements for major systems.

    Science.gov (United States)

    2010-10-01

    ... performance-based logistics arrangements as well as to weapon systems and subsystems that are to be supported... are appropriate) throughout the program life cycle as a means to improve contractor performance; and... qualified sources in sourcing decisions as a part of past performance evaluations. (4) Whenever a...

  8. 33 CFR 207.800 - Collection of navigation statistics.

    Science.gov (United States)

    2010-07-01

    ... Orleans area dock for unloading. Company A, as barge owner, reports entire movements from Minneapolis to the unloading dock in New Orleans. Company B does not report any barge movement. (b) Implementation of... vessels shall be reported, including but not limited to: Dry cargo ship and tanker moves, loaded and empty...

  9. Coupling of Uranium and Thorium Series Isotope Systematics for Age Determination of Late Pleistocene Zircons using LA-ICP-MS

    Science.gov (United States)

    Sakata, S.; Hirakawa, S.; Iwano, H.; Danhara, T.; Hirata, T.

    2014-12-01

    Zircon U-Th-Pb dating method is one of the most important tools for estimating the duration of magmatism by means of coupling of uranium, actinium and thorium decay series. Using U-Pb dating method, its reliability is principally guaranteed by the concordance between 238U-206Pb and 235U-207Pb ages. In case of dating Quaternary zircons, however, the initial disequilibrium effect on 230Th and 231Pa should be considered. On the other hands, 232Th-208Pb dating method can be a simple but powerful approach for investigating the age of crystallization because of negligible influence from initial disequilibrium effect. We have developed a new correction model for accurate U-Pb dating of the young zircon samples by taking into consideration of initial disequilibrium and a U-Pb vs Th-Pb concordia diagram for reliable age calibration was successfully established. Hence, the U-Th-Pb dating method can be applied to various zircons ranging from Hadean (4,600 Ma) to Quaternary (~50 ka) ages, and this suggests that further detailed information concerning the thermal history of the geological sequences can be made by the coupling of U-Th-Pb, fission track and Ar-Ar ages. In this presentation, we will show an example of U-Th-Pb dating for zircon samples from Sambe Volcano (3 to 100 ka), southwest Japan and the present dating technique using LA-ICP-MS.

  10. Estudo retrospectivo de 207 casos de tumores mamários em gatas A retrospective study of 207 cases of mammary tumors in queens

    Directory of Open Access Journals (Sweden)

    Monique Togni

    2013-03-01

    Full Text Available Este estudo teve como objetivos determinar os tumores mais prevalentes em gatos e relacionar os tumores mamários a alguns de seus fatores prognósticos. Os arquivos do Laboratório de Patologia Veterinária (LPV da Universidade Federal de Santa Maria (UFSM foram revisados e um total de 1.427 protocolos de biopsias e necropsias de felinos, entre 2000 e 2011, foi encontrado. Com base nas informações dos arquivos, foi estabelecida a relação entre os tumores e alguns fatores como sexo, idade, raça, estado reprodutivo, uso de contraceptivos, número e localização das glândulas afetadas, ulcerações, tamanho do neoplasma, metástases distantes e para os linfonodos. Assim, observou-se que os tumores de mama foram o segundo diagnóstico mais prevalente, após os tumores de pele. Todos os gatos com tumores mamários eram fêmeas, sendo os sem raça definida e os idosos os mais afetados. Os neoplasmas malignos foram diagnosticados com maior frequência, seguidos pelos tumores não neoplásicos e pelos neoplasmas benignos. Os tumores menores eram, na sua maioria, carcinomas. Ulcerações estavam presentes não só em neoplasmas malignos, mas também em alterações não neoplásicas. Metástases distantes foram encontradas principalmente nos pulmões e na pele.This study aimed to determine the most prevalent mammary tumors in cats and associate them to some prognostic factors. The files from the Laboratório de Patologia Veterinária (LPV of the Universidade Federal de Santa Maria (UFSM were reviewed, and 1.427 feline biopsies and autopsy protocols between the years 2000 and 2011 were found. Based on the information retrieved from the files, a relationship was established among the tumors and some prognostic factors such as sex, age, breed, reproductive status, use of contraceptives, number and location of affected glands, ulcers, size of the neoplasm, distant metastases, and affected lymph nodes. Thus, it was observed that mammary cancer is the second most prevalent diagnosis, following skin tumors. All cats with mammary tumors were female, being the elderly and mixed breed the most affected. Malignant neoplasms were the most frequently diagnosed, followed by non-neoplastic tumors, and benign neoplasms. Smaller tumors were mostly carcinomas. Ulcerations were present not only in malignant neoplasms but also in non-neoplastic changes. Distant metastases were found mainly to the lungs and skin.

  11. India's Information Technology Sector: What Contribution to Broader Economic Development? OECD Development Centre Working Paper, No. 207 (Formerly Technical Paper No. 207)

    Science.gov (United States)

    Singh, Nirvikar

    2003-01-01

    What contribution can information technology (IT) make to India's overall economic development? This paper provides an analytical framework centred around the concepts of comparative advantage, complementarities, and innovation. There is strong evidence that India has a strong and sustainable comparative advantage in software development and…

  12. 41 CFR 101-42.207 - Transfer of hazardous materials and certain categories of property.

    Science.gov (United States)

    2010-07-01

    ..., in block 13c or as an addendum, or an MSDS or HMIS data. In the absence of an MSDS, the HMIS data which fulfills the MSDS requirements must be attached if the receiving activity does not have the HMIS..., storage, or use of the item. If available, an MSDS or a citation or copy of the HMIS data must be filed...

  13. 49 CFR 180.207 - Requirements for requalification of UN pressure receptacles.

    Science.gov (United States)

    2010-10-01

    ... beyond its 15-years authorized service life. A pressure receptacle with a specified service life may not be refilled and offered for transportation after its authorized service life has expired unless... must be a water jacket volumetric expansion test suitable for the determination of the cylinder...

  14. 48 CFR 705.207 - Preparation and transmittal of certain synopses.

    Science.gov (United States)

    2010-10-01

    ... INTERNATIONAL DEVELOPMENT ACQUISITION PLANNING PUBLICIZING CONTRACT ACTIONS Synopsis of Proposed Contract... notify USAID's Office of Small and Disadvantaged Business Utilization (OSDBU) at least seven business days before publicizing a solicitation in the Commerce Business Daily for an acquisition: (a) Which...

  15. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (207b-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  16. MO-AB-207-00: ACR Update in MR, CT, Nuclear Medicine, and Mammography

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

  17. MO-AB-207-03: ACR Update in Nuclear Medicine

    Energy Technology Data Exchange (ETDEWEB)

    Harkness, B. [Henry Ford Hospital System (United States)

    2015-06-15

    A goal of an imaging accreditation program is to ensure adequate image quality, verify appropriate staff qualifications, and to assure patient and personnel safety. Currently, more than 35,000 facilities in 10 modalities have been accredited by the American College of Radiology (ACR), making the ACR program one of the most prolific accreditation options in the U.S. In addition, ACR is one of the accepted accreditations required by some state laws, CMS/MIPPA insurance and others. Familiarity with the ACR accreditation process is therefore essential to clinical diagnostic medical physicists. Maintaining sufficient knowledge of the ACR program must include keeping up-to-date as the various modality requirements are refined to better serve the goals of the program and to accommodate newer technologies and practices. This session consists of presentations from authorities in four ACR accreditation modality programs, including magnetic resonance imaging, computed tomography, nuclear medicine, and mammography. Each speaker will discuss the general components of the modality program and address any recent changes to the requirements. Learning Objectives: To understand the requirements of the ACR MR Accreditation program. The discussion will include accreditation of whole-body general purpose magnets, dedicated extremity systems well as breast MRI accreditation. Anticipated updates to the ACR MRI Quality Control Manual will also be reviewed. To understand the requirements of the ACR CT accreditation program, including updates to the QC manual as well as updates through the FAQ process. To understand the requirements of the ACR nuclear medicine accreditation program, and the role of the physicist in annual equipment surveys and the set up and supervision of the routine QC program. To understand the current ACR MAP Accreditation requirement and present the concepts and structure of the forthcoming ACR Digital Mammography QC Manual and Program.

  18. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (207a-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  19. Creative Accounting Model for Increasing Banking Industries’ Competitive Advantage in Indonesia (P.197-207)

    OpenAIRE

    Supriyati Supriyati; Erida Herlina

    2017-01-01

    Bank Indonesia demands that the national banks should improve their transparency of financial condition and performance for public in line with the development of their products and activities. Furthermore, the banks’ financial statements of Bank Indonesia have become the basis for determining the status of their soundness. In fact, they tend to practice earnings management in order that they can meet the criteria required by Bank Indonesia. For internal purposes, the initiative of earning ma...

  20. The K-Pg Event-Bed at ODP 207 Reloaded: Search for the Meteoritic Component

    Science.gov (United States)

    Deutsch, A.; Vollmer, C.; Tagle, R.; Salge, T.; Hansen, B.; Ott, U.; Hoppe, P.; Berndt, J.

    2013-09-01

    We report on the search for traces of the Chicxulub bolide in the K-Pg bed drilled in the western tropical Atlantic, using advanced separation techniques and microanalytical tools with high spatial resolution.

  1. WE-D-207-01: Background and Clinical Implementation of a Screening Program

    Energy Technology Data Exchange (ETDEWEB)

    Aberle, D. [UCLA, Los Angeles, CA (United States)

    2015-06-15

    In the United States, Lung Cancer is responsible for more cancer deaths than the next four cancers combined. In addition, the 5 year survival rate for lung cancer patients has not improved over the past 40 to 50 years. To combat this deadly disease, in 2002 the National Cancer Institute launched a very large Randomized Control Trial called the National Lung Screening Trial (NLST). This trial would randomize subjects who had substantial risk of lung cancer (due to age and smoking history) into either a Chest X-ray arm or a low dose CT arm. In November 2010, the National Cancer Institute announced that the NLST had demonstrated 20% fewer lung cancer deaths among those who were screened with low-dose CT than with chest X-ray. In December 2013, the US Preventive Services Task Force recommended the use of Lung Cancer Screening using low dose CT and a little over a year later (Feb. 2015), CMS announced that Medicare would also cover Lung Cancer Screening using low dose CT. Thus private and public insurers are required to provide Lung Cancer Screening programs using CT to the appropriate population(s). The purpose of this Symposium is to inform medical physicists and prepare them to support the implementation of Lung Screening programs. This Symposium will focus on the clinical aspects of lung cancer screening, requirements of a screening registry for systematically capturing and tracking screening patients and results (such as required Medicare data elements) as well as the role of the medical physicist in screening programs, including the development of low dose CT screening protocols. Learning Objectives: To understand the clinical basis and clinical components of a lung cancer screening program, including eligibility criteria and other requirements. To understand the data collection requirements, workflow, and informatics infrastructure needed to support the tracking and reporting components of a screening program. To understand the role of the medical physicist in implementing Lung Cancer Screening protocols for CT, including utilizing resources such as the AAPM Protocols and the ACR Designated Lung Screening Center program. UCLA Department of Radiology has an Institutional research agreement with Siemens Healthcare; Dr. McNitt-Gray has been a recipient of Research Support from Siemens Healthcare in the past. Dr. Aberle has been a Member of Advisory Boards for the LUNGevity Foundation (2011-present) and Siemens Medical Solutions. (2013)

  2. WE-B-207-00: CT Lung Cancer Screening Part 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    The US National Lung Screening Trial (NLST) was a multi-center randomized, controlled trial comparing a low-dose CT (LDCT) to posterior-anterior (PA) chest x-ray (CXR) in screening older, current and former heavy smokers for early detection of lung cancer. Recruitment was launched in September 2002 and ended in April 2004 when 53,454 participants had been randomized at 33 screening sites in equal proportions. Funded by the National Cancer Institute this trial demonstrated that LDCT screening reduced lung cancer mortality. The US Preventive Services Task Force (USPSTF) cited NLST findings and conclusions in its deliberations and analysis of lung cancer screening. Under the 2010 Patient Protection and Affordable Care Act, the USPSTF favorable recommendation regarding lung cancer CT screening assisted in obtaining third-party payers coverage for screening. The objective of this session is to provide an introduction to the NLST and the trial findings, in addition to a comprehensive review of the dosimetry investigations and assessments completed using individual NLST participant CT and CXR examinations. Session presentations will review and discuss the findings of two independent assessments, a CXR assessment and the findings of a CT investigation calculating individual organ dosimetry values. The CXR assessment reviewed a total of 73,733 chest x-ray exams that were performed on 92 chest imaging systems of which 66,157 participant examinations were used. The CT organ dosimetry investigation collected scan parameters from 23,773 CT examinations; a subset of the 75,133 CT examinations performed using 97 multi-detector CT scanners. Organ dose conversion coefficients were calculated using a Monte Carlo code. An experimentally-validated CT scanner simulation was coupled with 193 adult hybrid computational phantoms representing the height and weight of the current U.S. population. The dose to selected organs was calculated using the organ dose library and the abstracted scan parameters. This session will review the results and summarize the individualized doses to major organs and the mean effective dose and CTDIvol estimate for 66,157 PA chest and 23,773 CT examinations respectively, using size-dependent computational phantoms coupled with Monte Carlo calculations. Learning Objectives: Review and summarize relevant NLST findings and conclusions. Understand the scope and scale of the NLST specific to participant dosimetry. Provide a comprehensive review of NLST participant dosimetry assessments. Summarize the results of an investigation providing individualized organ dose estimates for NLST participant cohorts.

  3. WE-D-207-02: Capturing Data Elements and the Role of Imaging Informatics

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, W. [University of California, Los Angeles (United States)

    2015-06-15

    In the United States, Lung Cancer is responsible for more cancer deaths than the next four cancers combined. In addition, the 5 year survival rate for lung cancer patients has not improved over the past 40 to 50 years. To combat this deadly disease, in 2002 the National Cancer Institute launched a very large Randomized Control Trial called the National Lung Screening Trial (NLST). This trial would randomize subjects who had substantial risk of lung cancer (due to age and smoking history) into either a Chest X-ray arm or a low dose CT arm. In November 2010, the National Cancer Institute announced that the NLST had demonstrated 20% fewer lung cancer deaths among those who were screened with low-dose CT than with chest X-ray. In December 2013, the US Preventive Services Task Force recommended the use of Lung Cancer Screening using low dose CT and a little over a year later (Feb. 2015), CMS announced that Medicare would also cover Lung Cancer Screening using low dose CT. Thus private and public insurers are required to provide Lung Cancer Screening programs using CT to the appropriate population(s). The purpose of this Symposium is to inform medical physicists and prepare them to support the implementation of Lung Screening programs. This Symposium will focus on the clinical aspects of lung cancer screening, requirements of a screening registry for systematically capturing and tracking screening patients and results (such as required Medicare data elements) as well as the role of the medical physicist in screening programs, including the development of low dose CT screening protocols. Learning Objectives: To understand the clinical basis and clinical components of a lung cancer screening program, including eligibility criteria and other requirements. To understand the data collection requirements, workflow, and informatics infrastructure needed to support the tracking and reporting components of a screening program. To understand the role of the medical physicist in implementing Lung Cancer Screening protocols for CT, including utilizing resources such as the AAPM Protocols and the ACR Designated Lung Screening Center program. UCLA Department of Radiology has an Institutional research agreement with Siemens Healthcare; Dr. McNitt-Gray has been a recipient of Research Support from Siemens Healthcare in the past. Dr. Aberle has been a Member of Advisory Boards for the LUNGevity Foundation (2011-present) and Siemens Medical Solutions. (2013)

  4. WE-D-207-00: CT Lung Cancer Screening and the Medical Physicist: Moving Forward

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    In the United States, Lung Cancer is responsible for more cancer deaths than the next four cancers combined. In addition, the 5 year survival rate for lung cancer patients has not improved over the past 40 to 50 years. To combat this deadly disease, in 2002 the National Cancer Institute launched a very large Randomized Control Trial called the National Lung Screening Trial (NLST). This trial would randomize subjects who had substantial risk of lung cancer (due to age and smoking history) into either a Chest X-ray arm or a low dose CT arm. In November 2010, the National Cancer Institute announced that the NLST had demonstrated 20% fewer lung cancer deaths among those who were screened with low-dose CT than with chest X-ray. In December 2013, the US Preventive Services Task Force recommended the use of Lung Cancer Screening using low dose CT and a little over a year later (Feb. 2015), CMS announced that Medicare would also cover Lung Cancer Screening using low dose CT. Thus private and public insurers are required to provide Lung Cancer Screening programs using CT to the appropriate population(s). The purpose of this Symposium is to inform medical physicists and prepare them to support the implementation of Lung Screening programs. This Symposium will focus on the clinical aspects of lung cancer screening, requirements of a screening registry for systematically capturing and tracking screening patients and results (such as required Medicare data elements) as well as the role of the medical physicist in screening programs, including the development of low dose CT screening protocols. Learning Objectives: To understand the clinical basis and clinical components of a lung cancer screening program, including eligibility criteria and other requirements. To understand the data collection requirements, workflow, and informatics infrastructure needed to support the tracking and reporting components of a screening program. To understand the role of the medical physicist in implementing Lung Cancer Screening protocols for CT, including utilizing resources such as the AAPM Protocols and the ACR Designated Lung Screening Center program. UCLA Department of Radiology has an Institutional research agreement with Siemens Healthcare; Dr. McNitt-Gray has been a recipient of Research Support from Siemens Healthcare in the past. Dr. Aberle has been a Member of Advisory Boards for the LUNGevity Foundation (2011-present) and Siemens Medical Solutions. (2013)

  5. 49 CFR 232.207 - Class IA brake tests-1,000-mile inspection.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Class IA brake tests-1,000-mile inspection. 232... Class IA brake tests—1,000-mile inspection. (a) Except as provided in § 232.213, each train shall receive a Class IA brake test performed by a qualified person, as defined in § 232.5, at a location...

  6. 76 FR 5518 - Federal Housing Administration (FHA): Refinancing an Existing Cooperative Under Section 207...

    Science.gov (United States)

    2011-02-01

    ... facing a credit crunch. Lenders' efforts to increase capital reserves and loan committee efforts to... significant effect on a substantial number of small entities, HUD specifically invites comments regarding any...) (UMRA) establishes requirements for federal agencies to assess the effects of their regulatory...

  7. 18 CFR 1304.207 - Channel excavation on TVA-owned residential access shoreland.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Channel excavation on... Resources TENNESSEE VALLEY AUTHORITY APPROVAL OF CONSTRUCTION IN THE TENNESSEE RIVER SYSTEM AND REGULATION... excavation on TVA-owned residential access shoreland. (a) Excavation of individual boat channels shall be...

  8. 30 CFR 250.207 - What ancillary activities may I conduct?

    Science.gov (United States)

    2010-07-01

    ..., geotechnical, archaeological, biological, physical oceanographic, meteorological, socioeconomic, or other surveys; or (c) Studies that model potential oil and hazardous substance spills, drilling muds...

  9. WE-H-207B-02: MR-Driven RT Planning.

    Science.gov (United States)

    Cao, M

    2016-06-01

    In recent years, steady progress has been made towards the implementation of MRI in external beam radiation therapy for processes ranging from treatment simulation to in-room guidance. Novel procedures relying mostly on MR data are currently implemented in the clinic. This session will cover topics such as (a) commissioning and quality control of the MR in-room imagers and simulators specific to RT, (b) treatment planning requirements, constraints and challenges when dealing with various MR data, (c) quantification of organ motion with an emphasis on treatment delivery guidance, and (d) MR-driven strategies for adaptive RT workflows. The content of the session was chosen to address both educational and practical key aspects of MR guidance.

  10. 7 CFR 205.207 - Wild-crop harvesting practice standard.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling..., labeled, or represented as organic must be harvested from a designated area that has had no...

  11. 19 CFR 207.93 - Protection of proprietary information during panel and committee proceedings.

    Science.gov (United States)

    2010-04-01

    ... Government of Mexico who the Canadian Minister of Trade or the Mexican Secretary of Economia, as the case may... Economia, as the case may be, has notified the Commission Secretary that such person requires access....

  12. 34 CFR 668.207 - Preventing evasion of the consequences of cohort default rates.

    Science.gov (United States)

    2010-07-01

    ... indirectly— (1) Holds or held a managerial role; or (2) Has or had the ability to affect substantially the... change; and (3) There is a commonality of ownership or management between you and the ineligible... management. For the purposes of this section, a commonality of ownership or management exists if, at each...

  13. MO-DE-207-04: Imaging educational program on solutions to common pediatric imaging challenges

    Energy Technology Data Exchange (ETDEWEB)

    Krishnamurthy, R. [Texas Children’s Hospital: Pediatric MRI Quality, Artifacts, and Safety (United States)

    2015-06-15

    This imaging educational program will focus on solutions to common pediatric imaging challenges. The speakers will present collective knowledge on best practices in pediatric imaging from their experience at dedicated children’s hospitals. The educational program will begin with a detailed discussion of the optimal configuration of fluoroscopes for general pediatric procedures. Following this introduction will be a focused discussion on the utility of Dual Energy CT for imaging children. The third lecture will address the substantial challenge of obtaining consistent image post -processing in pediatric digital radiography. The fourth and final lecture will address best practices in pediatric MRI including a discussion of ancillary methods to reduce sedation and anesthesia rates. Learning Objectives: To learn techniques for optimizing radiation dose and image quality in pediatric fluoroscopy To become familiar with the unique challenges and applications of Dual Energy CT in pediatric imaging To learn solutions for consistent post-processing quality in pediatric digital radiography To understand the key components of an effective MRI safety and quality program for the pediatric practice.

  14. 7 CFR 1486.207 - What is the Technical Issues Resolution Fund?

    Science.gov (United States)

    2010-01-01

    ... strategic areas of longer term interest. Funding decisions are determined primarily through a review process... CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS EMERGING MARKETS...

  15. Substitute potting compounds for Sylgard 93-120. Process Development Endeavor Nos. 203 and 207

    Energy Technology Data Exchange (ETDEWEB)

    Flowers, G.L.; Switzer, S.T.

    1979-07-01

    The report deals with the development of substitute potting compounds to replace the no longer available Dow Corning 93-120. Three different approaches to formulate a substitute, two of which were successful are presented. The efforts discussed are a part of a laarger project to better understand the silicone potting compound technology and to formulate substitutes for specific materials which have been discontinued by Dow Corning.

  16. Estudo retrospectivo de 207 casos de tumores mamários em gatas

    Directory of Open Access Journals (Sweden)

    Monique Togni

    2013-03-01

    Full Text Available Este estudo teve como objetivos determinar os tumores mais prevalentes em gatos e relacionar os tumores mamários a alguns de seus fatores prognósticos. Os arquivos do Laboratório de Patologia Veterinária (LPV da Universidade Federal de Santa Maria (UFSM foram revisados e um total de 1.427 protocolos de biopsias e necropsias de felinos, entre 2000 e 2011, foi encontrado. Com base nas informações dos arquivos, foi estabelecida a relação entre os tumores e alguns fatores como sexo, idade, raça, estado reprodutivo, uso de contraceptivos, número e localização das glândulas afetadas, ulcerações, tamanho do neoplasma, metástases distantes e para os linfonodos. Assim, observou-se que os tumores de mama foram o segundo diagnóstico mais prevalente, após os tumores de pele. Todos os gatos com tumores mamários eram fêmeas, sendo os sem raça definida e os idosos os mais afetados. Os neoplasmas malignos foram diagnosticados com maior frequência, seguidos pelos tumores não neoplásicos e pelos neoplasmas benignos. Os tumores menores eram, na sua maioria, carcinomas. Ulcerações estavam presentes não só em neoplasmas malignos, mas também em alterações não neoplásicas. Metástases distantes foram encontradas principalmente nos pulmões e na pele.

  17. Magnetic properties of R2Mn207 pyrochlore rare-earth solid solutions

    OpenAIRE

    Imamura, N.; Karppinen, Maarit; Yamauchi, H.; Goodenough, J. B.

    2010-01-01

    Three (R,R′)2Mn2O7 ferromagnetic pyrochlore systems were studied to investigate the role of the R3+ ionic size versus 4f moment on the magnetic properties of the Mn2O7 sublattice. The Curie temperature TC=18±1 K for R=Y and Lu remained nearly constant for (Y1−xLux)2Mn2O7 but the magnetization data show characteristics of spin-glass behavior in low magnetic fields, and at 5 T, the magnetization fails to reach the expected 3 μB/Mn4+ found by 0.5 T in Tl2Mn2O7 and In2Mn2O7. A frustrated, minor a...

  18. TU-G-207-01: CT Imaging Using Energy-Sensitive Photon-Counting Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Taguchi, K. [Johns Hopkins University (United States)

    2015-06-15

    Last few years has witnessed the development of novel of X-ray imaging modalities, such as spectral CT, phase contrast CT, and X-ray acoustic/fluorescence/luminescence imaging. This symposium will present the recent advances of these emerging X-ray imaging modalities and update the attendees with knowledge in various related topics, including X-ray photon-counting detectors, X-ray physics underlying the emerging applications beyond the traditional X-ray imaging, image reconstruction for the novel modalities, characterization and evaluation of the systems, and their practical implications. In addition, the concept and practical aspects of X-ray activatable targeted nanoparticles for molecular X-ray imaging will be discussed in the context of X-ray fluorescence and luminescence CT. Learning Objectives: Present background knowledge of various emerging X-ray imaging techniques, such as spectral CT, phase contrast CT and X-ray fluorescence/luminescence CT. Discuss the practical need, technical aspects and current status of the emerging X-ray imaging modalities. Describe utility and future impact of the new generation of X-ray imaging applications.

  19. 5 CFR 536.207 - Loss of eligibility for grade retention.

    Science.gov (United States)

    2010-01-01

    ... before the commencement of the 2-year period of grade retention: (1) The employee has a break in service... terminate the benefits of grade retention; or (6) The employee moves to a position not under a covered pay... reasonable offer for grade retention purposes; or (2) The employee fails to enroll in, or to comply with...

  20. New high spin states and isomers in the {sup 208}Pb and {sup 207}Pb nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Broda, R.; Wrzesinski, J.; Pawlat, T. [and others

    1996-12-31

    The two most prominent examples of the heavy doubly closed shell (DCS) nuclei, {sup 208}Pb and {sup 132}Sn, are not accessible by conventional heavy-ion fusion processes populating high-spin states. This experimental difficulty obscured for a long time the investigation of yrast high-spin states in both DCS and neighboring nuclei and consequently restricted the study of the shell model in its most attractive regions. Recent technical development of multidetector gamma arrays opened new ways to exploit more complex nuclear processes which populate the nuclei of interest with suitable yields for gamma spectroscopy and involve population of moderately high spin states. This new possibility extended the range of accessible spin values and is a promising way to reach new yrast states. Some of these states are expected to be of high configurational purity and can be a source of important shell model parameters which possibly can be used later to check the validity of the spherical shell model description at yet higher spin and higher excitation energy. The nuclei in the closest vicinity of {sup 132}Sn are produced in spontaneous fission and states with spin values up to I=14 can be reached in fission gamma spectroscopy studies with the presently achieved sensitivity of gamma arrays. New results on yrast states in the {sup 134}Te and {sup 135}I nuclei populated in fission of the {sup 248}Cm presented at this conference illustrate such application of the resolving power offered by modern gamma techniques.

  1. WE-FG-207A-02: Why We Need Breast CT? - Clinical Perspective.

    Science.gov (United States)

    O'Connell, A

    2016-06-01

    Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar "densities", making lesion detection more difficult. We ideally need 3-D imaging for imaging the 3-D breast. MRI is 3-D, whole breast ultrasound is 3-D, digital breast tomosynthesis is called 3-D but is really "pseudo 3-D" due to poor resolution along the depth-direction. Also, and importantly, we need to be able to administer intravenous contrast agents for optimal imaging, similar to other organ systems in the body. Dedicated breast CT allows for 3-D imaging of the uncompressed breast. In current designs, the patient is positioned prone on the table and the breast is pendant through an aperture and the scan takes approximately 10 seconds [O'Connell et al., AJR 195: 496-509, 2010]. Almost on the heels of the invention of CT itself, work began on the development of dedicated breast CT. These early breast CT systems were used in clinical trials and the results from comparative performance evaluation of breast CT and mammography for 1625 subjects were reported in 1980 [Chang et al., Cancer 46: 939-46, 1980]. However, the technological limitations at that time stymied clinical translation for decades. Subsequent to the landmark article in 2001 [Boone et al., Radiology 221: 657-67, 2001] that demonstrated the potential feasibility in terms of radiation dose, multiple research groups are actively investigating dedicated breast CT. The development of large-area flat-panel detectors with field-of-view sufficient to image the entire breast in each projection enabled development of flat-panel cone-beam breast CT. More recently, the availability of complimentary metal-oxide semiconductor (CMOS) detectors with lower system noise and finer pixel pitch, combined with the development of x-ray tubes with focal spot dimensions similar to mammography systems, has shown improved spatial resolution and could improve visualization of microcalcifications. These technological developments promise clinical translation of low-dose cone-beam breast CT. Dedicated photon-counting breast CT (pcBCT) systems represent a novel detector design, which provide high spatial resolution (∼ 100µm) and low mean glandular dose (MGD). The CdTe-based direct conversion detector technology was previously evaluated and confirmed by simulations and basic experiments on laboratory setups [Kalender et al., Eur Radiol 22: 1-8, 2012]. Measurements of dose, technical image quality parameters, and surgical specimens on a pcBCT scanner have been completed. Comparative evaluation of surgical specimens showed that pcBCT outperformed mammography and digital breast tomosynthesis with respect to 3D spatial resolution, detectability of calcifications, and soft tissue delineation. Major barriers to widespread clinical use of BCT relate to radiation dose, imaging of microcalcifications, and adequate coverage of breast tissue near the chest wall. Adequate chest wall coverage is also technically challenging but recent progress in x-ray tube, detector and table design now enables full breast coverage in the majority of patients. At this time, BCT has been deemed to be suitable for diagnostic imaging but not yet for screening. The mean glandular dose (MGD) from BCT has been reported to be between 5.7 to 27.8 mGy, and this range is comparable to, and within the range of, the MGD of 2.6 to 31.6 mGy in diagnostic mammography. In diagnostic studies, the median MGD from BCT and mammography were 12.6 and 11.1 mGy

  2. WE-FG-207A-01: Introduction to Dedicated Breast CT - Early Studies.

    Science.gov (United States)

    Vedantham, S

    2016-06-01

    Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar "densities", making lesion detection more difficult. We ideally need 3-D imaging for imaging the 3-D breast. MRI is 3-D, whole breast ultrasound is 3-D, digital breast tomosynthesis is called 3-D but is really "pseudo 3-D" due to poor resolution along the depth-direction. Also, and importantly, we need to be able to administer intravenous contrast agents for optimal imaging, similar to other organ systems in the body. Dedicated breast CT allows for 3-D imaging of the uncompressed breast. In current designs, the patient is positioned prone on the table and the breast is pendant through an aperture and the scan takes approximately 10 seconds [O'Connell et al., AJR 195: 496-509, 2010]. Almost on the heels of the invention of CT itself, work began on the development of dedicated breast CT. These early breast CT systems were used in clinical trials and the results from comparative performance evaluation of breast CT and mammography for 1625 subjects were reported in 1980 [Chang et al., Cancer 46: 939-46, 1980]. However, the technological limitations at that time stymied clinical translation for decades. Subsequent to the landmark article in 2001 [Boone et al., Radiology 221: 657-67, 2001] that demonstrated the potential feasibility in terms of radiation dose, multiple research groups are actively investigating dedicated breast CT. The development of large-area flat-panel detectors with field-of-view sufficient to image the entire breast in each projection enabled development of flat-panel cone-beam breast CT. More recently, the availability of complimentary metal-oxide semiconductor (CMOS) detectors with lower system noise and finer pixel pitch, combined with the development of x-ray tubes with focal spot dimensions similar to mammography systems, has shown improved spatial resolution and could improve visualization of microcalcifications. These technological developments promise clinical translation of low-dose cone-beam breast CT. Dedicated photon-counting breast CT (pcBCT) systems represent a novel detector design, which provide high spatial resolution (∼ 100µm) and low mean glandular dose (MGD). The CdTe-based direct conversion detector technology was previously evaluated and confirmed by simulations and basic experiments on laboratory setups [Kalender et al., Eur Radiol 22: 1-8, 2012]. Measurements of dose, technical image quality parameters, and surgical specimens on a pcBCT scanner have been completed. Comparative evaluation of surgical specimens showed that pcBCT outperformed mammography and digital breast tomosynthesis with respect to 3D spatial resolution, detectability of calcifications, and soft tissue delineation. Major barriers to widespread clinical use of BCT relate to radiation dose, imaging of microcalcifications, and adequate coverage of breast tissue near the chest wall. Adequate chest wall coverage is also technically challenging but recent progress in x-ray tube, detector and table design now enables full breast coverage in the majority of patients. At this time, BCT has been deemed to be suitable for diagnostic imaging but not yet for screening. The mean glandular dose (MGD) from BCT has been reported to be between 5.7 to 27.8 mGy, and this range is comparable to, and within the range of, the MGD of 2.6 to 31.6 mGy in diagnostic mammography. In diagnostic studies, the median MGD from BCT and mammography were 12.6 and 11.1 mGy

  3. WE-FG-207A-00: Advances in Dedicated Breast CT.

    Science.gov (United States)

    Vedantham, Srinivasan; Molloi, Sabee

    2016-06-01

    Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar "densities", making lesion detection more difficult. We ideally need 3-D imaging for imaging the 3-D breast. MRI is 3-D, whole breast ultrasound is 3-D, digital breast tomosynthesis is called 3-D but is really "pseudo 3-D" due to poor resolution along the depth-direction. Also, and importantly, we need to be able to administer intravenous contrast agents for optimal imaging, similar to other organ systems in the body. Dedicated breast CT allows for 3-D imaging of the uncompressed breast. In current designs, the patient is positioned prone on the table and the breast is pendant through an aperture and the scan takes approximately 10 seconds [O'Connell et al., AJR 195: 496-509, 2010]. Almost on the heels of the invention of CT itself, work began on the development of dedicated breast CT. These early breast CT systems were used in clinical trials and the results from comparative performance evaluation of breast CT and mammography for 1625 subjects were reported in 1980 [Chang et al., Cancer 46: 939-46, 1980]. However, the technological limitations at that time stymied clinical translation for decades. Subsequent to the landmark article in 2001 [Boone et al., Radiology 221: 657-67, 2001] that demonstrated the potential feasibility in terms of radiation dose, multiple research groups are actively investigating dedicated breast CT. The development of large-area flat-panel detectors with field-of-view sufficient to image the entire breast in each projection enabled development of flat-panel cone-beam breast CT. More recently, the availability of complimentary metal-oxide semiconductor (CMOS) detectors with lower system noise and finer pixel pitch, combined with the development of x-ray tubes with focal spot dimensions similar to mammography systems, has shown improved spatial resolution and could improve visualization of microcalcifications. These technological developments promise clinical translation of low-dose cone-beam breast CT. Dedicated photon-counting breast CT (pcBCT) systems represent a novel detector design, which provide high spatial resolution (∼ 100µm) and low mean glandular dose (MGD). The CdTe-based direct conversion detector technology was previously evaluated and confirmed by simulations and basic experiments on laboratory setups [Kalender et al., Eur Radiol 22: 1-8, 2012]. Measurements of dose, technical image quality parameters, and surgical specimens on a pcBCT scanner have been completed. Comparative evaluation of surgical specimens showed that pcBCT outperformed mammography and digital breast tomosynthesis with respect to 3D spatial resolution, detectability of calcifications, and soft tissue delineation. Major barriers to widespread clinical use of BCT relate to radiation dose, imaging of microcalcifications, and adequate coverage of breast tissue near the chest wall. Adequate chest wall coverage is also technically challenging but recent progress in x-ray tube, detector and table design now enables full breast coverage in the majority of patients. At this time, BCT has been deemed to be suitable for diagnostic imaging but not yet for screening. The mean glandular dose (MGD) from BCT has been reported to be between 5.7 to 27.8 mGy, and this range is comparable to, and within the range of, the MGD of 2.6 to 31.6 mGy in diagnostic mammography. In diagnostic studies, the median MGD from BCT and mammography were 12.6 and 11.1 mGy

  4. WE-FG-207A-04: Performance Characteristics of Photon-Counting Breast CT.

    Science.gov (United States)

    Kalender, W

    2016-06-01

    Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar "densities", making lesion detection more difficult. We ideally need 3-D imaging for imaging the 3-D breast. MRI is 3-D, whole breast ultrasound is 3-D, digital breast tomosynthesis is called 3-D but is really "pseudo 3-D" due to poor resolution along the depth-direction. Also, and importantly, we need to be able to administer intravenous contrast agents for optimal imaging, similar to other organ systems in the body. Dedicated breast CT allows for 3-D imaging of the uncompressed breast. In current designs, the patient is positioned prone on the table and the breast is pendant through an aperture and the scan takes approximately 10 seconds [O'Connell et al., AJR 195: 496-509, 2010]. Almost on the heels of the invention of CT itself, work began on the development of dedicated breast CT. These early breast CT systems were used in clinical trials and the results from comparative performance evaluation of breast CT and mammography for 1625 subjects were reported in 1980 [Chang et al., Cancer 46: 939-46, 1980]. However, the technological limitations at that time stymied clinical translation for decades. Subsequent to the landmark article in 2001 [Boone et al., Radiology 221: 657-67, 2001] that demonstrated the potential feasibility in terms of radiation dose, multiple research groups are actively investigating dedicated breast CT. The development of large-area flat-panel detectors with field-of-view sufficient to image the entire breast in each projection enabled development of flat-panel cone-beam breast CT. More recently, the availability of complimentary metal-oxide semiconductor (CMOS) detectors with lower system noise and finer pixel pitch, combined with the development of x-ray tubes with focal spot dimensions similar to mammography systems, has shown improved spatial resolution and could improve visualization of microcalcifications. These technological developments promise clinical translation of low-dose cone-beam breast CT. Dedicated photon-counting breast CT (pcBCT) systems represent a novel detector design, which provide high spatial resolution (∼ 100µm) and low mean glandular dose (MGD). The CdTe-based direct conversion detector technology was previously evaluated and confirmed by simulations and basic experiments on laboratory setups [Kalender et al., Eur Radiol 22: 1-8, 2012]. Measurements of dose, technical image quality parameters, and surgical specimens on a pcBCT scanner have been completed. Comparative evaluation of surgical specimens showed that pcBCT outperformed mammography and digital breast tomosynthesis with respect to 3D spatial resolution, detectability of calcifications, and soft tissue delineation. Major barriers to widespread clinical use of BCT relate to radiation dose, imaging of microcalcifications, and adequate coverage of breast tissue near the chest wall. Adequate chest wall coverage is also technically challenging but recent progress in x-ray tube, detector and table design now enables full breast coverage in the majority of patients. At this time, BCT has been deemed to be suitable for diagnostic imaging but not yet for screening. The mean glandular dose (MGD) from BCT has been reported to be between 5.7 to 27.8 mGy, and this range is comparable to, and within the range of, the MGD of 2.6 to 31.6 mGy in diagnostic mammography. In diagnostic studies, the median MGD from BCT and mammography were 12.6 and 11.1 mGy

  5. 40 CFR 600.207-93 - Calculation of fuel economy values for a model type.

    Science.gov (United States)

    2010-07-01

    ... base level. (7) For alcohol dual fuel automobiles and natural gas dual fuel automobiles the procedures... combined fuel economy values from the tests performed using gasoline or diesel test fuel. (ii) Calculate... economy values for the model type. (5) For alcohol dual fuel automobiles and natural gas dual fuel...

  6. WE-DE-207A-04: Advances in Radiological Neuro-Endovascular Interventional Imaging.

    Science.gov (United States)

    Rudin, S

    2016-06-01

    1. Parallels in the evolution of x-ray angiographic systems and devices used for minimally invasive endovascular therapy Charles Strother - DSA, invented by Dr. Charles Mistretta at UW-Madison, was the technology which enabled the development of minimally invasive endovascular procedures. As DSA became widely available and the potential benefits for accessing the cerebral vasculature from an endovascular approach began to be apparent, industry began efforts to develop tools for use in these procedures. Along with development of catheters, embolic materials, pushable coils and the GDC coils there was simultaneous development and improvement of 2D DSA image quality and the introduction of 3D DSA. Together, these advances resulted in an enormous expansion in the scope and numbers of minimally invasive endovascular procedures. The introduction of flat detectors for c-arm angiographic systems in 2002 provided the possibility of the angiographic suite becoming not just a location for vascular imaging where physiological assessments might also be performed. Over the last decade algorithmic and hardware advances have been sufficient to now realize this potential in clinical practice. The selection of patients for endovascular treatments is enhanced by this dual capability. Along with these advances has been a steady reduction in the radiation exposure required so that today, vascular and soft tissue images may be obtained with equal or in many cases less radiation exposure than is the case for comparable images obtained with multi-detector CT.

  7. 207梅尼埃病的基因学研究进展

    Institute of Scientific and Technical Information of China (English)

    孙燕; 刘博; 戴海江

    2003-01-01

    梅尼埃病(MD)病因至今不明.随着基因分析技术的进步,MD的基因学研究受到了越来越多的关注.目前MD的基因学研究主要围绕着人类白细胞抗原,水通道蛋白和COCH基因展开.本文主要就上述基因的特征以及与MD的相关研究进行综述.

  8. DE0823$-$49 is a juvenile binary brown dwarf at 20.7 pc

    CERN Document Server

    Sahlmann, J; Martín, E L; Lazorenko, P F; Gagliuffi, D C Bardalez; Mayor, M; Ségransan, D; Queloz, D; Udry, S

    2015-01-01

    Astrometric monitoring of the nearby early-L dwarf DE0823$-$49 has revealed a low-mass companion in a 248-day orbit that was announced in an earlier work. Here, we present new astrometric and spectroscopic observations that allow us to characterise the system in detail. The optical spectrum shows LiI-absorption indicative of a young age and/or substellar mass for the primary component. The near-infrared spectrum is best reproduced by a binary system of brown dwarfs with spectral types of L1.5 $+$ L5.5 and effective temperatures of $2150\\pm100$ K and $1670\\pm140$ K. To conform with the photocentric orbit size measured with astrometry and the current understanding of substellar evolution, the system must have an age in the 80--500 Myr range. Evolutionary models predict component masses in the ranges of $M_1\\simeq0.028-0.063\\,M_\\odot$ and $M_2\\simeq0.018-0.045\\,M_\\odot$ with a mass ratio of $q\\simeq0.64-0.74$. Multi-epoch radial velocity measurements unambiguously establish the three-dimensional orbit of the sys...

  9. DE0823-49 is a juvenile binary brown dwarf at 20.7 pc

    Science.gov (United States)

    Sahlmann, J.; Burgasser, A. J.; Martín, E. L.; Lazorenko, P. F.; Bardalez Gagliuffi, D. C.; Mayor, M.; Ségransan, D.; Queloz, D.; Udry, S.

    2015-07-01

    Astrometric monitoring of the nearby early-L dwarf DE0823-49 has revealed a low-mass companion in a 248-day orbit that was announced in an earlier work. Here, we present new astrometric and spectroscopic observations that allow us to characterise the system in detail. The optical spectrum shows Li i-absorption indicative of a young age and/or substellar mass for the primary component. The near-infrared spectrum is best reproduced by a binary system of brown dwarfs with spectral types of L1.5 + L5.5 and effective temperatures of 2150 ± 100 K and 1670 ± 140 K. To conform with the photocentric orbit size measured with astrometry and the current understanding of substellar evolution, the system must have an age in the 80-500 Myr range. Evolutionary models predict component masses in the ranges of M1 ≃ 0.028-0.063 M⊙ and M2 ≃ 0.018-0.045 M⊙ with a mass ratio of q ≃ 0.64-0.74. Multi-epoch radial velocity measurements unambiguously establish the three-dimensional orbit of the system and allow us to investigate its kinematic properties. DE0823-49 emerges as a rare example of a nearby brown dwarf binary with orbit, component properties, and age that are characterised well. It is a juvenile resident of the solar neighbourhood, but does not appear to belong to a known young association or moving group. Based on observations made with ESO telescopes at the La Silla Paranal Observatory under programme IDs 086.C-0680, 088.C-0679, 090.C-0786, and 092.C-0202.

  10. 33 CFR 207.340 - Reservoirs at headwaters of the Mississippi River; use and administration.

    Science.gov (United States)

    2010-07-01

    ..., the dams, dikes or their appurtenances, or to prevent damage to lands or structures above or below the... appurtenances, its dikes and embankments; and should floating bodies lying above or below a dam constitute at... to remove them immediately. (g) Trespass. No one shall trespass on any reservoir dam,...

  11. 19 CFR 207.7 - Limited disclosure of certain business proprietary information under administrative protective...

    Science.gov (United States)

    2010-04-01

    ... an attorney, accountant, or other professional, referral to the ethics panel of the appropriate professional association; (4) Such other administrative sanctions as the Commission determines to...

  12. TU-AB-207A-01: Image Acquisition Physics and Hardware.

    Science.gov (United States)

    Li, B

    2016-06-01

    Practicing medical physicists are often time charged with the tasks of evaluating and troubleshooting complex image quality issues related to CT scanners. This course will equip them with a solid and practical understanding of common CT imaging chain and its major components with emphasis on acquisition physics and hardware, reconstruction, artifacts, image quality, dose, and advanced clinical applications. The core objective is to explain the effects of these major system components on the image quality. This course will not focus on the rapid-changing advanced technologies given the two-hour time limit, but the fundamental principles discussed in this course may facilitate better understanding of those more complicated technologies. The course will begin with an overview of CT acquisition physics and geometry. X-ray tube and CT detector are important acquisition hardware critical to the overall image quality. Each of these two subsystems consists of several major components. An in-depth description of the function and failure modes of these components will be provided. Examples of artifacts related to these failure modes will be presented: off-focal radiation, tube arcing, heel effect, oil bubble, offset drift effect, cross-talk effect, and bad pixels. The fundamentals of CT image reconstruction will first be discussed on an intuitive level. Approaches that do not require rigorous derivation of mathematical formulations will be presented. This is followed by a detailed derivation of the Fourier slice theorem: the foundation of the FBP algorithm. FBP for parallel-beam, fan-beam, and cone-beam geometries will be discussed. To address the issue of radiation dose related to x-ray CT, recent advances in iterative reconstruction, their advantages, and clinical applications will also be described. Because of the nature of fundamental physics and mathematics, limitations in data acquisition, and non-ideal conditions of major system components, image artifact often arise in the reconstructed images. Because of the limited scope of this course, only major imaging artifacts, their appearance, and possible mitigation and corrections will be discussed. Assessment of the performance of a CT scanner is a complicated subject. Procedures to measure common image quality metrics such as high contrast spatial resolution, low contrast detectability, and slice profile will be described. The reason why these metrics used for FBP may not be sufficient for statistical iterative reconstruction will be explained. Optimizing radiation dose requires comprehension of CT dose metrics. This course will briefly describe various dose metrics, and interaction with acquisition parameters and patient habitus. CT is among the most frequently used imaging tools due to its superior image quality, easy to operate, and a broad range of applications. This course will present several interesting CT applications such as a mobile CT unit on an ambulance for stroke patients, low dose lung cancer screening, and single heartbeat cardiac CT.

  13. 47 CFR 95.207 - (R/C Rule 7) On what channels may I operate?

    Science.gov (United States)

    2010-10-01

    ... caused to the remote control of industrial equipment operating on the same or adjacent frequencies or to... RADIO SERVICES PERSONAL RADIO SERVICES Radio Control (R/C) Radio Service How to Operate An R/c Station... of an aircraft) or a model surface craft device (any small imitation of a boat, car or vehicle...

  14. Tank 241-T-105, cores 205 and 207 analytical results for the final report

    Energy Technology Data Exchange (ETDEWEB)

    Esch, R. A.

    1997-10-21

    This document is the final laboratory report for tank 241-T-105 push mode core segments collected between June 24, 1997 and June 30, 1997. The segments were subsampled and analyzed in accordance with the {ital Tank Push Mode Core Sampling and Analysis Plan} (TSAP) (Field,1997), the {ital Tank Safety Screening Data Quality Objective} (Safety DQO) (Dukelow, et al., 1995) and {ital Tank 241-T-105 Sample Analysis} (memo) (Field, 1997a). The analytical results are included in Table 1. None of the subsamples submitted for the differential scanning calorimetry (DSC) analysis or total alpha activity (AT) exceeded the notification limits as stated in the TSAP (Field, 1997). The statistical results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems (TWRS) Technical Basis Group in accordance with the Memorandum of Understanding (Schreiber, 1997) and not considered in this report.

  15. 12 CFR 303.207 - Restricted activities for critically undercapitalized institutions.

    Science.gov (United States)

    2010-01-01

    ... necessary to carry out any other requirement of any law, regulation, or order; (4) Make any material change... Federal Reserve Act (12 U.S.C. 371c(b)); (6) Pay excessive compensation or bonuses. Part 364 of this... liabilities at a rate that would increase the institution's weighted average cost of funds to a level...

  16. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (207a-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  17. 精致生活——东风标致207两厢

    Institute of Scientific and Technical Information of China (English)

    吴中元; 丛军(摄影)

    2009-01-01

    一直想要一种精致的生活,但这样的精致究竟要如何实现,自己却又说不清楚。是在疲惫的午间休息时间抱一个超大杯的Starbucks吗?抑或是不时去法式餐厅体会红酒中单宁留在口中微微发涩的感觉?

  18. 76 FR 207 - Intent To Prepare an Environmental Impact Statement for Proposed Transit Improvements to the...

    Science.gov (United States)

    2011-01-03

    ... Rogers Avenue and removing Jarvis station. Modernization 3-Track Alternative: This alternative would... Rogers Avenue and remove Jarvis station. Possible Effects The purpose of this Tier 1 EIS process is...

  19. TU-CD-207-11: Patient-Driven Automatic Exposure Control for Dedicated Breast CT

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez, A; Gazi, P [Biomedical Engineering Graduate Group, University of California Davis, Davis, CA (United States); Department of Radiology, UC Davis Medical Center, Sacramento, CA (United States); Seibert, J; Boone, J [Department of Radiology, UC Davis Medical Center, Sacramento, CA (United States); Department of Biomedical Engineering, University of California Davis, Davis, CA (United States)

    2015-06-15

    Purpose: To implement automatic exposure control (AEC) in dedicated breast CT (bCT) on a patient-specific basis using only the pre-scan scout views. Methods: Using a large cohort (N=153) of bCT data sets, the breast effective diameter (D) and width in orthogonal planes (Wa,Wb) were calculated from the reconstructed bCT image and pre-scan scout views, respectively. D, Wa, and Wb were measured at the breast center-of-mass (COM), making use of the known geometry of our bCT system. These data were then fit to a second-order polynomial “D=F(Wa,Wb)” in a least squares sense in order to provide a functional form for determining the breast diameter. The coefficient of determination (R{sup 2}) and mean percent error between the measured breast diameter and fit breast diameter were used to evaluate the overall robustness of the polynomial fit. Lastly, previously-reported bCT technique factors derived from Monte Carlo simulations were used to determine the tube current required for each breast diameter in order to match two-view mammographic dose levels. Results: F(Wa,Wb) provided fitted breast diameters in agreement with the measured breast diameters resulting in R{sup 2} values ranging from 0.908 to 0.929 and mean percent errors ranging from 3.2% to 3.7%. For all 153 bCT data sets used in this study, the fitted breast diameters ranged from 7.9 cm to 15.7 cm corresponding to tube current values ranging from 0.6 mA to 4.9 mA in order to deliver the same dose as two-view mammography in a 50% glandular breast with a 80 kV x-ray beam and 16.6 second scan time. Conclusion: The present work provides a robust framework for AEC in dedicated bCT using only the width measurements derived from the two orthogonal pre-scan scout views. Future work will investigate how these automatically chosen exposure levels affect the quality of the reconstructed image.

  20. TU-EF-207-02: Spectral Mammography Based on Photon Counting Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Molloi, S. [University of California (United States)

    2015-06-15

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  1. TU-EF-207-04: Advances in Detector Technology for Breast Tomosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, W. [SUNY Stony Brook (United States)

    2015-06-15

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  2. TU-EF-207-01: Introductory Remarks on Recent Advances in Breast Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Karellas, A. [University of Massachusetts Medical School (United States)

    2015-06-15

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  3. TU-CD-207-01: Characterization of Breast Tissue Composition Using Spectral Mammography

    Energy Technology Data Exchange (ETDEWEB)

    Ding, H; Cho, H; Kumar, N; Sennung, D; Ng, A Lam; Molloi, S [Department of radiological scicens, University of California, Irvine, CA (United States)

    2015-06-15

    Purpose: To investigate the feasibility of characterizing the chemical composition of breast tissue, in terms of water and lipid, by using spectral mammography in simulation and postmortem studies. Methods: Analytical simulations were performed to obtain low- and high-energy signals of breast tissue based on previously reported water, lipid, and protein contents. Dual-energy decomposition was used to characterize the simulated breast tissue into water and lipid basis materials and the measured water density was compared to the known value. In experimental studies, postmortem breasts were imaged with a spectral mammography system based on a scanning multi-slit Si strip photon-counting detector. Low- and high-energy images were acquired simultaneously from a single exposure by sorting the recorded photons into the corresponding energy bins. Dual-energy material decomposition of the low- and high-energy images yielded individual pixel measurements of breast tissue composition in terms of water and lipid thicknesses. After imaging, each postmortem breast was chemically decomposed into water, lipid and protein. The water density calculated from chemical analysis was used as the reference gold standard. Correlation of the water density measurements between spectral mammography and chemical analysis was analyzed using linear regression. Results: Both simulation and postmortem studies showed good linear correlation between the decomposed water thickness using spectral mammography and chemical analysis. The slope of the linear fitting function in the simulation and postmortem studies were 1.15 and 1.21, respectively. Conclusion: The results indicate that breast tissue composition, in terms of water and lipid, can be accurately measured using spectral mammography. Quantitative breast tissue composition can potentially be used to stratify patients according to their breast cancer risk.

  4. TU-EF-207-05: Dedicated Cone-beam Breast CT

    Energy Technology Data Exchange (ETDEWEB)

    Vedantham, S. [Univ. of Massachusetts Medical School (United States)

    2015-06-15

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  5. 33 CFR 207.50 - Hudson River Lock at Troy, N.Y.; navigation.

    Science.gov (United States)

    2010-07-01

    ... navigating the lock or not. No one shall cause any movement of any vessel, boat, or other floating thing in... paragraph. If the traffic is crowded in both directions; up and down lockages will usually be...

  6. 33 CFR 207.441 - St. Marys Falls Canal and Locks, Mich.; security.

    Science.gov (United States)

    2010-07-01

    ... channel within the limits of the lock piers either above or below the lock, in the direction of the tank.... Tank vessels to which this paragraph (b)(4)(ii) applies include those vessels carrying fuel oil... gate to the vessel. Luggage will be subject to inspection. (ii) Debarking. The vessel master...

  7. 33 CFR 207.20 - Cape Cod Canal, Mass.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... sex, race, creed, color or national origin. No lessee, licensee, or concessionaire providing a service... national origin in the conduct of operations under the lease, license or concession contract. (2) Motor.... (i) No person shall bring or have horses in camping, picnic, swimming beaches or developed recreation...

  8. Creative Accounting Model for Increasing Banking Industries’ Competitive Advantage in Indonesia (P.197-207

    Directory of Open Access Journals (Sweden)

    Supriyati Supriyati

    2017-01-01

    Full Text Available Bank Indonesia demands that the national banks should improve their transparency of financial condition and performance for public in line with the development of their products and activities. Furthermore, the banks’ financial statements of Bank Indonesia have become the basis for determining the status of their soundness. In fact, they tend to practice earnings management in order that they can meet the criteria required by Bank Indonesia. For internal purposes, the initiative of earning management has a positive impact on the performance of management. However, for the users of financial statements, it may differ, for example for the value of company, length of time the financial audit, and other aspects of tax evasion by the banks. This study tries to find out 1 the effect of GCG on Earnings Management, 2 the effect of earning management on Company value, the Audit Report Lag, and Taxation, and 3 the effect of Audit Report Lag on Corporate Value and Taxation. This is a quantitative research with the data collected from the bank financial statements, GCG implementation report, and the banks’ annual reports of 2003-2013. There were 41 banks taken using purposive sampling, as listed on the Indonesia Stock Exchange. The results showed that the implementation of GCG affects the occurrence of earning management. Accounting policy flexibility through earning management is expected to affect the length of the audit process and the accuracy of the financial statements presentation on public side. This research is expected to provide managerial implications in order to consider the possibility of earnings management practices in the banking industry. In the long term, earning management is expected to improve the banks’ competitiveness through an increase in the value of the company. Explicitly, earning management also affects the tax avoidance; therefore, the banks intend to pay lower taxes without breaking the existing legislation Taxation Provisions.Keywords: Good Corporate Governance (GCG, earning management, Audit Report lag, Company value, and tax avoidance

  9. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (207b-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  10. SU-C-207B-02: Maximal Noise Reduction Filter with Anatomical Structures Preservation

    Energy Technology Data Exchange (ETDEWEB)

    Maitree, R; Guzman, G; Chundury, A; Roach, M; Yang, D [Washington University School of Medicine, St Louis, MO (United States)

    2016-06-15

    Purpose: All medical images contain noise, which can result in an undesirable appearance and can reduce the visibility of anatomical details. There are varieties of techniques utilized to reduce noise such as increasing the image acquisition time and using post-processing noise reduction algorithms. However, these techniques are increasing the imaging time and cost or reducing tissue contrast and effective spatial resolution which are useful diagnosis information. The three main focuses in this study are: 1) to develop a novel approach that can adaptively and maximally reduce noise while preserving valuable details of anatomical structures, 2) to evaluate the effectiveness of available noise reduction algorithms in comparison to the proposed algorithm, and 3) to demonstrate that the proposed noise reduction approach can be used clinically. Methods: To achieve a maximal noise reduction without destroying the anatomical details, the proposed approach automatically estimated the local image noise strength levels and detected the anatomical structures, i.e. tissue boundaries. Such information was used to adaptively adjust strength of the noise reduction filter. The proposed algorithm was tested on 34 repeating swine head datasets and 54 patients MRI and CT images. The performance was quantitatively evaluated by image quality metrics and manually validated for clinical usages by two radiation oncologists and one radiologist. Results: Qualitative measurements on repeated swine head images demonstrated that the proposed algorithm efficiently removed noise while preserving the structures and tissues boundaries. In comparisons, the proposed algorithm obtained competitive noise reduction performance and outperformed other filters in preserving anatomical structures. Assessments from the manual validation indicate that the proposed noise reduction algorithm is quite adequate for some clinical usages. Conclusion: According to both clinical evaluation (human expert ranking) and qualitative assessment, the proposed approach has superior noise reduction and anatomical structures preservation capabilities over existing noise removal methods. Senior Author Dr. Deshan Yang received research funding form ViewRay and Varian.

  11. Comparative genomic analysis of secondary metabolite biosynthetic gene clusters in 207 isolates of Fusarium

    Science.gov (United States)

    Fusarium species are known for their ability to produce secondary metabolites (SMs), including plant hormones, pigments, mycotoxins, and other compounds with potential agricultural, pharmaceutical, and biotechnological impact. Understanding the distribution of SM biosynthetic gene clusters across th...

  12. 33 CFR 207.440 - St. Marys Falls Canal and Locks, Mich.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false St. Marys Falls Canal and Locks.... Marys Falls Canal and Locks, Mich.; use, administration, and navigation. (a) The use, administration... by radiotelephone to the Corps of Engineers Chief Lockmaster at St. Marys Falls Canal dispatch...

  13. 49 CFR 236.207 - Electric lock on hand-operated switch; control.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Electric lock on hand-operated switch; control... switch; control. Electric lock on hand-operated switch shall be controlled so that it cannot be unlocked until control circuits of signals governing movements over such switch have been opened. Approach...

  14. 24 CFR 982.207 - Waiting list: Local preferences in admission to program.

    Science.gov (United States)

    2010-04-01

    ... crime of violence (as defined in 18 U.S.C. 16). (b) Particular local preferences—(1) Residency..., color, ethnic origin, gender, religion, disability, or age of any member of an applicant family. (iv) A...) Preference for victims of domestic violence. The PHA should consider whether to adopt a local preference...

  15. PS2-07: The Association of Cyberbullying with Cardiovascular Health in Adolescents: A Preliminary Analysis

    Science.gov (United States)

    Cassidy-Bushrow, Andrea; Johnson, Dayna; Joseph, Christine

    2011-01-01

    Background/Aims With increasing access to the internet and other technology, adolescents may become victims of online harassment, referred to as cyberbullying. Cyberbullying may cause worry, fear, and distress among youth, all which increase cardiovascular disease (CVD) risk in adults. To our knowledge, no study has examined the potential association of cyberbullying with CVD risk factors in adolescents. We examined the association of cyberbullying with overweight/obesity and elevated blood pressure (BP) among healthy adolescents. Methods Adolescents age 14–17 years and parent/guardian were invited to a research visit between November, 2009 and present. Height, weight, and BP were measured by trained staff and internet experiences quantified by questionnaire. Race was defined as African-American or other race. Cyberbullying was defined as self-report in the past year of being worried or threatened because of being bothered or harassed online or of being embarrassed by others online. Overweight/ obesity was defined as BMI >=85th percentile for gender and age. Elevated BP was defined as a SBP or DBP >=90th percentile for gender, age and height. Logistic regression models were fit to estimate the association of cyberbulling with overweight/obesity or elevated BP. Results As of October, 2010, 190 adolescents with complete data have been recruited into the study. Mean age was 16.5±1.0 years; 76 (40%) were male and 112 (59.0%) were African-American. Mean BMI of adolescents was 24.2±6.4 kg/m^2 and mean SBP and DBP were 117.7±11.3 mmHg and 63.9±7.1mmHg, respectively; 62 (32.6%) were classified as overweight/obese and 28 (14.7%) had an elevated BP. A total of 29 (15.3%) adolescents reported being cyberbullied; older adolescents (P=0.061) were more likely and African-Americans (P=0.040) were less likely to report being cyberbullied. Gender was not associated with cyberbullying (P=0.143). Cyberbullying was not associated with overweight/obesity (P=0.951) or elevated BP (P=0.701), after adjustment for other risk factors. Conclusions CVD risk factors in youth track into adulthood, thus early-life experiences represent important and potentially modifiable predictors of adult disease. In this study, self-reported experiences of cyberbullying were not associated with being overweight/obese or with elevated BP. Continued study of psychosocial risk factors, including cyberbullying, with adolescent CVD health is warranted.

  16. 207株肺炎克雷伯菌临床分布及耐药性分析%Clinical distribution and drug resistance analysis of 207 Klebsiella pneumoniae strains

    Institute of Scientific and Technical Information of China (English)

    龙绍芬; 黎铁斌

    2012-01-01

    目的 分析临床分离肺炎克雷伯菌对抗菌药物的耐药性.方法 对临床分离肺炎克雷伯菌用纸片扩散法(K-B)或微量稀释法对16种抗菌药物进行药物敏感试验.结果 产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌59株,对头孢曲松、头孢呋辛、头孢噻肟、头孢哌酮、头孢噻吩、复方新诺明、美洛西林有很高的耐药率,分别是91.53%、91.53%、100.00%、100.00%、93.22%、72.88%和91.53%,甚至出现多重耐药菌株.结论 产ESBLs肺炎克雷伯菌耐药情况非常严重,应加强医院感染监测和控制措施.%Objective To analyse the drug resistance of Klebsiella pneumoniae. Methods the disk diffusion method (KB) or mi cro dilution method (MIC) was used to detect the resistance rates of Klebsiella pneumoniae clinical isolates to 16 kinds of antibacte rial drugs. Results There were 59 strains of Klebsiella pneumoniae producing extended spectrum |3 lactamase (ESBLs) ,and they had high resistance rates to ceftriaxone(91. 53%) ,cefuroxime(91. 53%) , cefotaxime(100. 00%) ,cefoperazone(100. 00%) ,cepha lothin(93. 22%) ,co trimoxazole(72. 88%) ,mezlocillin(91. 53%) respectively. There are even multi drug resistant strains were de tected. Conclusion The drug resistance of ESBLs producing Klebsiella pneumoniae is very serious. The hospital infection surveil lance and control measures should be strengthen.

  17. SU-E-T-207: Comparison of Integrated Tissue Air Ratio (ITAR) to Traditional TAR for Kilovoltage Pencil-Beams

    Energy Technology Data Exchange (ETDEWEB)

    Hanlon, J; Koruga, I; Chell, E; Pintaske, R [Oraya Therapeutics Inc, Newark, CA (United States)

    2015-06-15

    Purpose: Clinically viable depth dose determination in kilovoltage pencil-beams is a great challenge that resulted in a published dosimetry method called ITAR, which involves measurement of air kerma and attenuation with a detector in a low scatter environment coupled with MCNP scatter calculations. The objective of this work is to compare ITAR to traditional TAR using inherently water-proof microchambers that have only recently become commercially available. Methods: An Exradin A26 microchamber was centered 150 mm from a 100 kVp x-ray source with 2 mm aluminum HVL. Depth dose in water from 16 to 24 mm in 2 mm increments was determined by: (1) placing blocks of Plastic Water LR near the source to minimize scatter and using previously published conversion coefficients [ITAR method] and (2) submerging the detector in a water tank with 2 mm thick Plastic Water LR walls and jogging the tank with motor controllers while keeping the detector position fixed [traditional TAR method]. Each method was repeated four to five times. For each repetition, dose was measured free in-air to normalize the data for exponential regression. Results: Traditional TAR indicated higher depth dose than ITAR; differences ranged from 2.1% at 24 mm depth to 2.5% at 16 mm depth. However, the results of traditional TAR did not include a correction for Pq,cham because it is unknown for this detector type in these conditions. It is estimated that the component of Pq,cham due to the effect of water displacement alone is ∼0.94, but Pq,cham is likely several percent larger than 0.94 due to the energy dependency of the microchamber in the presence of low energy scatter that is not present during in-air calibration. Conclusion: The ITAR method remains preferable for clinical depth dose determination in kilovoltage pencil-beams due to Pq,cham being unknown for suitable detectors in relevant conditions. All four of the authors are either current full time employees, which include stock option grants, or consultants of Oraya Therapeutics Inc.

  18. Disruption of the langerin/CD207 Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function

    Science.gov (United States)

    Kissenpfennig, Adrien; Aït-Yahia, Smina; Clair-Moninot, Valérie; Stössel, Hella; Badell, Edgar; Bordat, Yann; Pooley, Joanne L.; Lang, Thierry; Prina, Eric; Coste, Isabelle; Gresser, Olivia; Renno, Toufic; Winter, Nathalie; Milon, Geneviève; Shortman, Ken; Romani, Nikolaus; Lebecque, Serge; Malissen, Bernard; Saeland, Sem; Douillard, Patrice

    2005-01-01

    Langerin is a C-type lectin expressed by a subset of dendritic leukocytes, the Langerhans cells (LC). Langerin is a cell surface receptor that induces the formation of an LC-specific organelle, the Birbeck granule (BG). We generated a langerin−/− mouse on a C57BL/6 background which did not display any macroscopic aberrant development. In the absence of langerin, LC were detected in normal numbers in the epidermis but the cells lacked BG. LC of langerin−/− mice did not present other phenotypic alterations compared to wild-type littermates. Functionally, the langerin−/− LC were able to capture antigen, to migrate towards skin draining lymph nodes, and to undergo phenotypic maturation. In addition, langerin−/− mice were not impaired in their capacity to process native OVA protein for I-Ab-restricted presentation to CD4+ T lymphocytes or for H-2Kb-restricted cross-presentation to CD8+ T lymphocytes. langerin−/− mice inoculated with mannosylated or skin-tropic microorganisms did not display an altered pathogen susceptibility. Finally, chemical mutagenesis resulted in a similar rate of skin tumor development in langerin−/− and wild-type mice. Overall, our data indicate that langerin and BG are dispensable for a number of LC functions. The langerin−/− C57BL/6 mouse should be a valuable model for further functional exploration of langerin and the role of BG. PMID:15601833

  19. 33 CFR 207.420 - Chicago River, Ill.; Sanitary District controlling works, and the use, administration, and...

    Science.gov (United States)

    2010-07-01

    ... floating thing in the lock or approaches except by or under the direction of the lockmaster or his.... (8) Lockage of pleasure boats. The lockage of pleasure boats, house boats or like craft shall...

  20. Oahu Hyperspectral Imagery 2000 (207a-0613-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  1. Oahu Hyperspectral Imagery 2000 (207a-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  2. Oahu Hyperspectral Imagery 2000 (207b-0613-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  3. Sodium oxide and uranium oxide aerosol experiments: NSPP Tests 106-108 and Tests 204-207, data record report

    Energy Technology Data Exchange (ETDEWEB)

    Adams, R.E.; Kress, T.S.; Tobias, M.L.

    1981-03-01

    This data record report describes three sodium oxide aerosol tests and four uranium oxide aerosol tests conducted in the Nuclear Safety Pilot Plant project at Oak Ridge National Laboratory. The goal of this project is to establish the validity (or level of conservatism) of the aerosol behavioral code, HAARM-3, and follow-on codes under development at the Battelle Columbus Laboratories for the US Nuclear Regulatory Commission. Descriptions of the seven tests with tables and graphs summarizing the results are included. 92 figs.

  4. WE-FG-207A-03: Low-Dose Cone-Beam Breast CT: Physics and Technology Development.

    Science.gov (United States)

    Boone, J

    2016-06-01

    Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar "densities", making lesion detection more difficult. We ideally need 3-D imaging for imaging the 3-D breast. MRI is 3-D, whole breast ultrasound is 3-D, digital breast tomosynthesis is called 3-D but is really "pseudo 3-D" due to poor resolution along the depth-direction. Also, and importantly, we need to be able to administer intravenous contrast agents for optimal imaging, similar to other organ systems in the body. Dedicated breast CT allows for 3-D imaging of the uncompressed breast. In current designs, the patient is positioned prone on the table and the breast is pendant through an aperture and the scan takes approximately 10 seconds [O'Connell et al., AJR 195: 496-509, 2010]. Almost on the heels of the invention of CT itself, work began on the development of dedicated breast CT. These early breast CT systems were used in clinical trials and the results from comparative performance evaluation of breast CT and mammography for 1625 subjects were reported in 1980 [Chang et al., Cancer 46: 939-46, 1980]. However, the technological limitations at that time stymied clinical translation for decades. Subsequent to the landmark article in 2001 [Boone et al., Radiology 221: 657-67, 2001] that demonstrated the potential feasibility in terms of radiation dose, multiple research groups are actively investigating dedicated breast CT. The development of large-area flat-panel detectors with field-of-view sufficient to image the entire breast in each projection enabled development of flat-panel cone-beam breast CT. More recently, the availability of complimentary metal-oxide semiconductor (CMOS) detectors with lower system noise and finer pixel pitch, combined with the development of x-ray tubes with focal spot dimensions similar to mammography systems, has shown improved spatial resolution and could improve visualization of microcalcifications. These technological developments promise clinical translation of low-dose cone-beam breast CT. Dedicated photon-counting breast CT (pcBCT) systems represent a novel detector design, which provide high spatial resolution (∼ 100µm) and low mean glandular dose (MGD). The CdTe-based direct conversion detector technology was previously evaluated and confirmed by simulations and basic experiments on laboratory setups [Kalender et al., Eur Radiol 22: 1-8, 2012]. Measurements of dose, technical image quality parameters, and surgical specimens on a pcBCT scanner have been completed. Comparative evaluation of surgical specimens showed that pcBCT outperformed mammography and digital breast tomosynthesis with respect to 3D spatial resolution, detectability of calcifications, and soft tissue delineation. Major barriers to widespread clinical use of BCT relate to radiation dose, imaging of microcalcifications, and adequate coverage of breast tissue near the chest wall. Adequate chest wall coverage is also technically challenging but recent progress in x-ray tube, detector and table design now enables full breast coverage in the majority of patients. At this time, BCT has been deemed to be suitable for diagnostic imaging but not yet for screening. The mean glandular dose (MGD) from BCT has been reported to be between 5.7 to 27.8 mGy, and this range is comparable to, and within the range of, the MGD of 2.6 to 31.6 mGy in diagnostic mammography. In diagnostic studies, the median MGD from BCT and mammography were 12.6 and 11.1 mGy

  5. SU-D-207-04: GPU-Based 4D Cone-Beam CT Reconstruction Using Adaptive Meshing Method

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Z; Gu, X; Iyengar, P; Mao, W; Wang, J [UT Southwestern Medical Center, Dallas, TX (United States); Guo, X [University of Texas at Dallas, Richardson, TX (United States)

    2015-06-15

    Purpose: Due to the limited number of projections at each phase, the image quality of a four-dimensional cone-beam CT (4D-CBCT) is often degraded, which decreases the accuracy of subsequent motion modeling. One of the promising methods is the simultaneous motion estimation and image reconstruction (SMEIR) approach. The objective of this work is to enhance the computational speed of the SMEIR algorithm using adaptive feature-based tetrahedral meshing and GPU-based parallelization. Methods: The first step is to generate the tetrahedral mesh based on the features of a reference phase 4D-CBCT, so that the deformation can be well captured and accurately diffused from the mesh vertices to voxels of the image volume. After the mesh generation, the updated motion model and other phases of 4D-CBCT can be obtained by matching the 4D-CBCT projection images at each phase with the corresponding forward projections of the deformed reference phase of 4D-CBCT. The entire process of this 4D-CBCT reconstruction method is implemented on GPU, resulting in significantly increasing the computational efficiency due to its tremendous parallel computing ability. Results: A 4D XCAT digital phantom was used to test the proposed mesh-based image reconstruction algorithm. The image Result shows both bone structures and inside of the lung are well-preserved and the tumor position can be well captured. Compared to the previous voxel-based CPU implementation of SMEIR, the proposed method is about 157 times faster for reconstructing a 10 -phase 4D-CBCT with dimension 256×256×150. Conclusion: The GPU-based parallel 4D CBCT reconstruction method uses the feature-based mesh for estimating motion model and demonstrates equivalent image Result with previous voxel-based SMEIR approach, with significantly improved computational speed.

  6. SU-C-207-01: Four-Dimensional Inverse Geometry Computed Tomography: Concept and Its Validation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K; Kim, D; Kim, T; Kang, S; Cho, M; Shin, D; Suh, T [The Catholic University of Korea, Seoul (Korea, Republic of)

    2015-06-15

    Purpose: In past few years, the inverse geometry computed tomography (IGCT) system has been developed to overcome shortcomings of a conventional computed tomography (CT) system such as scatter problem induced from large detector size and cone-beam artifact. In this study, we intend to present a concept of a four-dimensional (4D) IGCT system that has positive aspects above all with temporal resolution for dynamic studies and reduction of motion artifact. Methods: Contrary to conventional CT system, projection data at a certain angle in IGCT was a group of fractionated narrow cone-beam projection data, projection group (PG), acquired from multi-source array which have extremely short time gap of sequential operation between each of sources. At this, for 4D IGCT imaging, time-related data acquisition parameters were determined by combining multi-source scanning time for collecting one PG with conventional 4D CBCT data acquisition sequence. Over a gantry rotation, acquired PGs from multi-source array were tagged time and angle for 4D image reconstruction. Acquired PGs were sorted into 10 phase and image reconstructions were independently performed at each phase. Image reconstruction algorithm based upon filtered-backprojection was used in this study. Results: The 4D IGCT had uniform image without cone-beam artifact on the contrary to 4D CBCT image. In addition, the 4D IGCT images of each phase had no significant artifact induced from motion compared with 3D CT. Conclusion: The 4D IGCT image seems to give relatively accurate dynamic information of patient anatomy based on the results were more endurable than 3D CT about motion artifact. From this, it will be useful for dynamic study and respiratory-correlated radiation therapy. This work was supported by the Industrial R&D program of MOTIE/KEIT [10048997, Development of the core technology for integrated therapy devices based on real-time MRI guided tumor tracking] and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning.

  7. TU-CD-207-04: Radiation Exposure Comparisons of CESM with 2D FFDM and 3D Tomosynthesis Mammography

    Energy Technology Data Exchange (ETDEWEB)

    James, J; Boltz, T; Pavlicek, W [Mayo Clinic Arizona, Scottsdale, AZ (United States)

    2015-06-15

    Purpose: While mammography is considered the standard for front-line breast cancer screening, image sensitivity and specificity can be affected by factors like dense breast tissue. Contrast-enhanced spectral mammography (CESM) shows promising initial results for dense breasts but comes at the cost of increased dose compared with full-field-digital-mammography (FFDM). The goal of this study is to quantitatively assess the dose increase of CESM in comparison with 2D-FFDM and 3D-Tomo at varying breast thickness. Methods: The experiments were conducted on a Hologic-Selenia-Dimensions system that performed 2D-FFDM, 3D-Tomo and CESM (high and low energies) on regular (50/50) and dense (70/30) breast tissue-mimicking phantoms. Both the phantoms had 6, 1-cm thick slabs (total thickness 6cm), compressed at 20-lbs using an 18×24 paddle. A single exposure was performed for each of the 3 mammo techniques with the following settings: AEC-Auto; Focal Spot-Large; kVp-Auto; mAs- Auto, Target/Filter combination-Auto; AEC Sensor/Exposure compensation Step-2/0. Average glandular dose (AGD) in mGy was obtained and compared as a function of breast thickness (1 – 6 cm) for both the phantom types. Results: The study shows that dose from the total CESM from 50/50 phantom at a breast thickness of a) 4.5 cm was 37.5% higher than 2D-FFDM and 30% higher than 3D-Tomo, b) 6 cm was 36.2% higher than 2D-FFDM and 41% higher than 3D-Tomo. For a dense breast tissue of 70/30 phantom, it was found that CESM dose at a breast thickness of: a) 4.5 cm was 33.3% higher than 2D-FFDM and 28.8% higher than 3D-Tomo, b) 6 cm was 35.4% higher than 2D-FFDM and 48.0% higher than 3D-Tomo. The overall CESM dose for the dense breast phantom was 12.5% higher at 4.5cm and 35% higher at 6 cm compared to the 50/50 phantom. Conclusion: This quantitative comparison study showed that CESM technique has an increased radiation dose compared to conventional 2D-FFDM and 3D-Tomo.

  8. WE-D-207-03: CT Protocols for Screening and the ACR Designated Lung Screening Program

    Energy Technology Data Exchange (ETDEWEB)

    McNitt-Gray, M. [UCLA School of Medicine (United States)

    2015-06-15

    In the United States, Lung Cancer is responsible for more cancer deaths than the next four cancers combined. In addition, the 5 year survival rate for lung cancer patients has not improved over the past 40 to 50 years. To combat this deadly disease, in 2002 the National Cancer Institute launched a very large Randomized Control Trial called the National Lung Screening Trial (NLST). This trial would randomize subjects who had substantial risk of lung cancer (due to age and smoking history) into either a Chest X-ray arm or a low dose CT arm. In November 2010, the National Cancer Institute announced that the NLST had demonstrated 20% fewer lung cancer deaths among those who were screened with low-dose CT than with chest X-ray. In December 2013, the US Preventive Services Task Force recommended the use of Lung Cancer Screening using low dose CT and a little over a year later (Feb. 2015), CMS announced that Medicare would also cover Lung Cancer Screening using low dose CT. Thus private and public insurers are required to provide Lung Cancer Screening programs using CT to the appropriate population(s). The purpose of this Symposium is to inform medical physicists and prepare them to support the implementation of Lung Screening programs. This Symposium will focus on the clinical aspects of lung cancer screening, requirements of a screening registry for systematically capturing and tracking screening patients and results (such as required Medicare data elements) as well as the role of the medical physicist in screening programs, including the development of low dose CT screening protocols. Learning Objectives: To understand the clinical basis and clinical components of a lung cancer screening program, including eligibility criteria and other requirements. To understand the data collection requirements, workflow, and informatics infrastructure needed to support the tracking and reporting components of a screening program. To understand the role of the medical physicist in implementing Lung Cancer Screening protocols for CT, including utilizing resources such as the AAPM Protocols and the ACR Designated Lung Screening Center program. UCLA Department of Radiology has an Institutional research agreement with Siemens Healthcare; Dr. McNitt-Gray has been a recipient of Research Support from Siemens Healthcare in the past. Dr. Aberle has been a Member of Advisory Boards for the LUNGevity Foundation (2011-present) and Siemens Medical Solutions. (2013)

  9. 5 CFR 1304.4608 - Administrative Enforcement Procedures (18 U.S.C. 207(j); 5 CFR 737.27).

    Science.gov (United States)

    2010-01-01

    ... MANAGEMENT AND BUDGET ADMINISTRATIVE PROCEDURES POST EMPLOYMENT CONFLICT OF INTEREST § 1304.4608... Office of General Counsel, OMB, shows that the information concerning a possible violation does not... allegations that may be damaging to his reputation. (i) Hearing rights. The hearing shall include, as a...

  10. 5 CFR Appendix B to Part 2641 - Agency Components for Purposes of 18 U.S.C. 207(c)

    Science.gov (United States)

    2010-01-01

    ... Service (effective March 6, 2008). National Telecommunications and Information Administration. United.... Community Relations Service. Criminal Division. Drug Enforcement Administration. Environment and Natural... Public Debt. Comptroller of the Currency. Financial Crimes Enforcement Center (FinCEN) (effective...

  11. 33 CFR 207.590 - Black Rock Canal and Lock at Buffalo, N.Y.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Black Rock Canal and Lock at... Black Rock Canal and Lock at Buffalo, N.Y.; use, administration, and navigation. (a) The term “canal” when used in this section will mean all of the Black Rock Waterway, including Black Rock Lock, and...

  12. 5 CFR 2641.207 - One-year restriction on any former private sector assignee under the Information Technology...

    Science.gov (United States)

    2010-01-01

    ... private sector assignee under the Information Technology Exchange Program representing, aiding, counseling... assignee under the Information Technology Exchange Program representing, aiding, counseling or assisting in... the Information Technology Exchange Program, 5 U.S.C. chapter 37, no former assignee shall...

  13. SU-F-207-14: Low Contrast Detectability (LCD) at Different Diagnostic Reference Levels for Adult Abdominal CT Procedures

    Energy Technology Data Exchange (ETDEWEB)

    Mahmood, U; Erdi, Y [Mem Sloan-Kettering Cancer Ctr, New York, NY (United States)

    2015-06-15

    Purpose Using diagnostic reference levels (DRL) to optimize CT protocols has potential to reduce radiation dose and meet regulatory requirements. However, DRL’s tend to be misconstrued as dose limits, are typically designed for specific patient populations, and are assumed to have acceptable image quality (AIQ) associated with them. To determine the image quality that is associated with established DRL’s for adult abdominal CT studies, a LCD phantom study was employed. Methods: A CT phantom (CIRS) containing three columns of 7 spherical targets, ranging from 10mm to 2.4 mm, that are 5, 10, and 20 HU below the background (HUBB) matrix was scanned with a GE HD750 64 slice scanner. The phantom was scanned at the NEXT 2006 25th CTDIvol of 12 mGy, the NCRP 172 achievable dose (AD) CTDIvol of 17 mGy and 75th CTDIvol of 25 mGy and at the ACR recommended CTDIvol of 25 mGy. It was also scanned at a CTDIvol 20% greater than the AD at 20 mGy and the ACR maximum threshold of 30 mGy. Results: At the NEXT 2006 25th percentile CTDIvol of 12 mGy, a 6.3 mm low contrast lesion was detectable in the 20 HUBB; 6.3 mm in the 10 HUBB and 10 mm in the 5 HUBB column. Increasing the CTDIvol to the NCRP 172 AD of 17 mGy, an additional 4.8 mm lesion was visualized in the 20 HUBB column. At 20 mGy, an additional 4.8 mm lesion was detectable in the 10 HUBB column. No further lesions were visible between 20 and 30 mGy. However, conspicuity of all lesions increased with each additional step up in CTDI. Conclusion: Optimizing radiation dose to achieve AIQ is a critical aspect of any dose optimization committee. Hence, judicious monitoring of radiation exposure to patients has to be balanced with diagnostic image quality.

  14. SU-D-207-01: Markerless Respiratory Motion Tracking with Contrast Enhanced Thoracic Cone Beam CT Projections

    Energy Technology Data Exchange (ETDEWEB)

    Chao, M; Yuan, Y; Rosenzweig, K; Lo, Y [The Mount Sinai Medical Center, New York, NY (United States); Brousmiche, S [Ion Beam Application, Louvain-la-neuve (Belgium)

    2015-06-15

    Purpose: To develop a novel technique to enhance the image contrast of clinical cone beam CT projections and extract respiratory signals based on anatomical motion using the modified Amsterdam Shroud (AS) method to benefit image guided radiation therapy. Methods: Thoracic cone beam CT projections acquired prior to treatment were preprocessed to increase their contrast for better respiratory signal extraction. Air intensity on raw images was firstly estimated and then applied to correct the projections to generate new attenuation images that were subsequently improved with deeper anatomy feature enhancement through taking logarithm operation, derivative along superior-inferior direction, respectively. All pixels on individual post-processed two dimensional images were horizontally summed to one column and all projections were combined side by side to create an AS image from which patient’s respiratory signal was extracted. The impact of gantry rotation on the breathing signal rendering was also investigated. Ten projection image sets from five lung cancer patients acquired with the Varian Onboard Imager on 21iX Clinac (Varian Medical Systems, Palo Alto, CA) were employed to assess the proposed technique. Results: Application of the air correction on raw projections showed that more than an order of magnitude of contrast enhancement was achievable. The typical contrast on the raw projections is around 0.02 while that on attenuation images could greater than 0.5. Clear and stable breathing signal can be reliably extracted from the new images while the uncorrected projection sets failed to yield clear signals most of the time. Conclusion: Anatomy feature plays a key role in yielding breathing signal from the projection images using the AS technique. The air correction process facilitated the contrast enhancement significantly and attenuation images thus obtained provides a practical solution to obtaining markerless breathing motion tracking.

  15. 33 CFR 207.180 - All waterways tributary to the Gulf of Mexico (except the Mississippi River, its tributaries...

    Science.gov (United States)

    2010-07-01

    ... navigation. (ii) From sunrise to sunset. Large discs, identical in color and number to the light signals... displayed at all locks as follows: (i) From sunset to sunrise. One green light shall indicate the lock...

  16. 33 CFR 207.718 - Navigation locks and approach channels, Columbia and Snake Rivers, Oreg. and Wash.

    Science.gov (United States)

    2010-07-01

    ... Ice Harbor, WUJ 43 Lower Monumental, WUJ 44 Little Goose, or WUJ 45 Lower Granite, at least one-half... chamber water level depth is 15 feet except at Ice Harbor where it is 14 feet and at Bonneville where it... appurtenance thereto, or machinery for operating the gates, or the walls protecting the banks of the...

  17. 33 CFR 207.680 - Willamette River, Oreg.; use, administration, and navigation of canal and locks at Willamette...

    Science.gov (United States)

    2010-07-01

    ... canal and locks and the grounds and public property pertaining thereto. He shall see that all laws... have aboard an adequate number of suitable fenders of timber, rubber, or rope which are to be placed... recognized by law as a trespass. (e) Definitions. Except as otherwise provided in paragraph (b)(6) of...

  18. WE-FG-207A-05: Dedicated Breast CT as a Diagnostic Imaging Tool: Physics and Clinical Feasibility.

    Science.gov (United States)

    Karellas, A

    2016-06-01

    Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar "densities", making lesion detection more difficult. We ideally need 3-D imaging for imaging the 3-D breast. MRI is 3-D, whole breast ultrasound is 3-D, digital breast tomosynthesis is called 3-D but is really "pseudo 3-D" due to poor resolution along the depth-direction. Also, and importantly, we need to be able to administer intravenous contrast agents for optimal imaging, similar to other organ systems in the body. Dedicated breast CT allows for 3-D imaging of the uncompressed breast. In current designs, the patient is positioned prone on the table and the breast is pendant through an aperture and the scan takes approximately 10 seconds [O'Connell et al., AJR 195: 496-509, 2010]. Almost on the heels of the invention of CT itself, work began on the development of dedicated breast CT. These early breast CT systems were used in clinical trials and the results from comparative performance evaluation of breast CT and mammography for 1625 subjects were reported in 1980 [Chang et al., Cancer 46: 939-46, 1980]. However, the technological limitations at that time stymied clinical translation for decades. Subsequent to the landmark article in 2001 [Boone et al., Radiology 221: 657-67, 2001] that demonstrated the potential feasibility in terms of radiation dose, multiple research groups are actively investigating dedicated breast CT. The development of large-area flat-panel detectors with field-of-view sufficient to image the entire breast in each projection enabled development of flat-panel cone-beam breast CT. More recently, the availability of complimentary metal-oxide semiconductor (CMOS) detectors with lower system noise and finer pixel pitch, combined with the development of x-ray tubes with focal spot dimensions similar to mammography systems, has shown improved spatial resolution and could improve visualization of microcalcifications. These technological developments promise clinical translation of low-dose cone-beam breast CT. Dedicated photon-counting breast CT (pcBCT) systems represent a novel detector design, which provide high spatial resolution (∼ 100µm) and low mean glandular dose (MGD). The CdTe-based direct conversion detector technology was previously evaluated and confirmed by simulations and basic experiments on laboratory setups [Kalender et al., Eur Radiol 22: 1-8, 2012]. Measurements of dose, technical image quality parameters, and surgical specimens on a pcBCT scanner have been completed. Comparative evaluation of surgical specimens showed that pcBCT outperformed mammography and digital breast tomosynthesis with respect to 3D spatial resolution, detectability of calcifications, and soft tissue delineation. Major barriers to widespread clinical use of BCT relate to radiation dose, imaging of microcalcifications, and adequate coverage of breast tissue near the chest wall. Adequate chest wall coverage is also technically challenging but recent progress in x-ray tube, detector and table design now enables full breast coverage in the majority of patients. At this time, BCT has been deemed to be suitable for diagnostic imaging but not yet for screening. The mean glandular dose (MGD) from BCT has been reported to be between 5.7 to 27.8 mGy, and this range is comparable to, and within the range of, the MGD of 2.6 to 31.6 mGy in diagnostic mammography. In diagnostic studies, the median MGD from BCT and mammography were 12.6 and 11.1 mGy

  19. Oahu Hyperspectral Imagery 2000 (207b-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  20. SU-C-207A-01: A Novel Maximum Likelihood Method for High-Resolution Proton Radiography/proton CT

    Energy Technology Data Exchange (ETDEWEB)

    Collins-Fekete, C [Universite Laval, Quebec, Quebec (Canada); Centre Hospitalier University de Quebec, Quebec, QC (Canada); Mass General Hospital (United States); Harvard Medical, Boston MA (United States); Schulte, R [Loma Linda University, Loma Linda, CA (United States); Beaulieu, L [Universite Laval, Quebec, Quebec (Canada); Centre Hospitalier University de Quebec, Quebec, QC (Canada); Seco, J [Mass General Hospital (United States); Harvard Medical, Boston MA (United States); Department of Medical Physics in Radiooncology, DKFZ German Cancer Research Center, Heidelberg (Germany)

    2016-06-15

    Purpose: Multiple Coulomb scattering is the largest contributor to blurring in proton imaging. Here we tested a maximum likelihood least squares estimator (MLLSE) to improve the spatial resolution of proton radiography (pRad) and proton computed tomography (pCT). Methods: The object is discretized into voxels and the average relative stopping power through voxel columns defined from the source to the detector pixels is optimized such that it maximizes the likelihood of the proton energy loss. The length spent by individual protons in each column is calculated through an optimized cubic spline estimate. pRad images were first produced using Geant4 simulations. An anthropomorphic head phantom and the Catphan line-pair module for 3-D spatial resolution were studied and resulting images were analyzed. Both parallel and conical beam have been investigated for simulated pRad acquisition. Then, experimental data of a pediatric head phantom (CIRS) were acquired using a recently completed experimental pCT scanner. Specific filters were applied on proton angle and energy loss data to remove proton histories that underwent nuclear interactions. The MTF10% (lp/mm) was used to evaluate and compare spatial resolution. Results: Numerical simulations showed improvement in the pRad spatial resolution for the parallel (2.75 to 6.71 lp/cm) and conical beam (3.08 to 5.83 lp/cm) reconstructed with the MLLSE compared to averaging detector pixel signals. For full tomographic reconstruction, the improved pRad were used as input into a simultaneous algebraic reconstruction algorithm. The Catphan pCT reconstruction based on the MLLSE-enhanced projection showed spatial resolution improvement for the parallel (2.83 to 5.86 lp/cm) and conical beam (3.03 to 5.15 lp/cm). The anthropomorphic head pCT displayed important contrast gains in high-gradient regions. Experimental results also demonstrated significant improvement in spatial resolution of the pediatric head radiography. Conclusion: The proposed MLLSE shows promising potential to increase the spatial resolution (up to 244%) in proton imaging.

  1. WE-EF-207-05: Monte Carlo Dosimetry for a Dedicated Cone-Beam CT Head Scanner

    Energy Technology Data Exchange (ETDEWEB)

    Sisniega, A; Zbijewski, W; Xu, J; Dang, H; Stayman, J W; Aygun, N; Koliatsos, V E; Siewerdsen, J H [Johns Hopkins University, Balitmore, MD (United States); Wang, X; Foos, D H [Carestream Health, Rochester, NY (United States)

    2015-06-15

    Purpose: Cone-Beam CT (CBCT) is an attractive platform for point-of-care imaging of traumatic brain injury and intracranial hemorrhage. This work implements and evaluates a fast Monte-Carlo (MC) dose estimation engine for development of a dedicated head CBCT scanner, optimization of acquisition protocols, geometry, bowtie filter designs, and patient-specific dosimetry. Methods: Dose scoring with a GPU-based MC CBCT simulator was validated on an imaging bench using a modified 16 cm CTDI phantom with 7 ion chamber shafts along the central ray for 80–100 kVp (+2 mm Al, +0.2 mm Cu). Dose distributions were computed in a segmented CBCT reconstruction of an anthropomorphic head phantom with 4×10{sup 5} tracked photons per scan (5 min runtime). Circular orbits with angular span ranging from short scan (180° + fan angle) to full rotation (360°) were considered for fixed total mAs per scan. Two aluminum filters were investigated: aggressive bowtie, and moderate bowtie (matched to 16 cm and 32 cm water cylinder, respectively). Results: MC dose estimates showed strong agreement with measurements (RMSE<0.001 mGy/mAs). A moderate (aggressive) bowtie reduced the dose, per total mAs, by 20% (30%) at the center of the head, by 40% (50%) at the eye lens, and by 70% (80%) at the posterior skin entrance. For the no bowtie configuration, a short scan reduced the eye lens dose by 62% (from 0.08 mGy/mAs to 0.03 mGy/mAs) compared to full scan, although the dose to spinal bone marrow increased by 40%. For both bowties, the short scan resulted in a similar 40% increase in bone marrow dose, but the reduction in the eye lens was more pronounced: 70% (90%) for the moderate (aggressive) bowtie. Conclusions: Dose maps obtained with validated MC simulation demonstrated dose reduction in sensitive structures (eye lens and bone marrow) through combination of short-scan trajectories and bowtie filters. Xiaohui Wang and David Foos are employees of Carestream Health.

  2. Draft assembly of elite inbred line PH207 provides insights into genomic and transcriptome diversity in maize

    Science.gov (United States)

    Intense artificial selection over the last 100 years has produced elite maize (Zea mays) inbred lines that combine to produce high-yielding hybrids. To further our understanding of how genome and transcriptome variation contribute to the production of high-yielding hybrids, we generated a draft geno...

  3. SU-F-207-06: CT-Based Assessment of Tumor Volume in Malignant Pleural Mesothelioma

    Energy Technology Data Exchange (ETDEWEB)

    Qayyum, F; Armato, S; Straus, C; Husain, A; Vigneswaran, W; Kindler, H [The University of Chicago, Chicago, IL (United States)

    2015-06-15

    Purpose: To determine the potential utility of computed tomography (CT) scans in the assessment of physical tumor bulk in malignant pleural mesothelioma patients. Methods: Twenty-eight patients with malignant pleural mesothelioma were used for this study. A CT scan was acquired for each patient prior to surgical resection of the tumor (median time between scan and surgery: 27 days). After surgery, the ex-vivo tumor volume was measured by a pathologist using a water displacement method. Separately, a radiologist identified and outlined the tumor boundary on each CT section that demonstrated tumor. These outlines then were analyzed to determine the total volume of disease present, the number of sections with outlines, and the mean volume of disease per outlined section. Subsets of the initial patient cohort were defined based on these parameters, i.e. cases with at least 30 sections of disease with a mean disease volume of at least 3mL per section. For each subset, the R- squared correlation between CT-based tumor volume and physical ex-vivo tumor volume was calculated. Results: The full cohort of 28 patients yielded a modest correlation between CT-based tumor volume and the ex-vivo tumor volume with an R-squared value of 0.66. In general, as the mean tumor volume per section increased, the correlation of CT-based volume with the physical tumor volume improved substantially. For example, when cases with at least 40 CT sections presenting a mean of at least 2mL of disease per section were evaluated (n=20) the R-squared correlation increased to 0.79. Conclusion: While image-based volumetry for mesothelioma may not generally capture physical tumor volume as accurately as one might expect, there exists a set of conditions in which CT-based volume is highly correlated with the physical tumor volume. SGA receives royalties and licensing fees through the University of Chicago for computer-aided diagnosis technology.

  4. SU-C-207B-04: Automated Segmentation of Pectoral Muscle in MR Images of Dense Breasts

    Energy Technology Data Exchange (ETDEWEB)

    Verburg, E; Waard, SN de; Veldhuis, WB; Gils, CH van; Gilhuijs, KGA [University Medical Center Utrecht, Utrecht (Netherlands)

    2016-06-15

    Purpose: To develop and evaluate a fully automated method for segmentation of the pectoral muscle boundary in Magnetic Resonance Imaging (MRI) of dense breasts. Methods: Segmentation of the pectoral muscle is an important part of automatic breast image analysis methods. Current methods for segmenting the pectoral muscle in breast MRI have difficulties delineating the muscle border correctly in breasts with a large proportion of fibroglandular tissue (i.e., dense breasts). Hence, an automated method based on dynamic programming was developed, incorporating heuristics aimed at shape, location and gradient features.To assess the method, the pectoral muscle was segmented in 91 randomly selected participants (mean age 56.6 years, range 49.5–75.2 years) from a large MRI screening trial in women with dense breasts (ACR BI-RADS category 4). Each MR dataset consisted of 178 or 179 T1-weighted images with voxel size 0.64 × 0.64 × 1.00 mm3. All images (n=16,287) were reviewed and scored by a radiologist. In contrast to volume overlap coefficients, such as DICE, the radiologist detected deviations in the segmented muscle border and determined whether the result would impact the ability to accurately determine the volume of fibroglandular tissue and detection of breast lesions. Results: According to the radiologist’s scores, 95.5% of the slices did not mask breast tissue in such way that it could affect detection of breast lesions or volume measurements. In 13.1% of the slices a deviation in the segmented muscle border was present which would not impact breast lesion detection. In 70 datasets (78%) at least 95% of the slices were segmented in such a way it would not affect detection of breast lesions, and in 60 (66%) datasets this was 100%. Conclusion: Dynamic programming with dedicated heuristics shows promising potential to segment the pectoral muscle in women with dense breasts.

  5. SU-C-207B-05: Tissue Segmentation of Computed Tomography Images Using a Random Forest Algorithm: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Polan, D [University of Michigan, Ann Arbor, MI (United States); Brady, S; Kaufman, R [St. Jude Children’s Research Hospital, Memphis, TN (United States)

    2016-06-15

    Purpose: Develop an automated Random Forest algorithm for tissue segmentation of CT examinations. Methods: Seven materials were classified for segmentation: background, lung/internal gas, fat, muscle, solid organ parenchyma, blood/contrast, and bone using Matlab and the Trainable Weka Segmentation (TWS) plugin of FIJI. The following classifier feature filters of TWS were investigated: minimum, maximum, mean, and variance each evaluated over a pixel radius of 2n, (n = 0–4). Also noise reduction and edge preserving filters, Gaussian, bilateral, Kuwahara, and anisotropic diffusion, were evaluated. The algorithm used 200 trees with 2 features per node. A training data set was established using an anonymized patient’s (male, 20 yr, 72 kg) chest-abdomen-pelvis CT examination. To establish segmentation ground truth, the training data were manually segmented using Eclipse planning software, and an intra-observer reproducibility test was conducted. Six additional patient data sets were segmented based on classifier data generated from the training data. Accuracy of segmentation was determined by calculating the Dice similarity coefficient (DSC) between manual and auto segmented images. Results: The optimized autosegmentation algorithm resulted in 16 features calculated using maximum, mean, variance, and Gaussian blur filters with kernel radii of 1, 2, and 4 pixels, in addition to the original CT number, and Kuwahara filter (linear kernel of 19 pixels). Ground truth had a DSC of 0.94 (range: 0.90–0.99) for adult and 0.92 (range: 0.85–0.99) for pediatric data sets across all seven segmentation classes. The automated algorithm produced segmentation with an average DSC of 0.85 ± 0.04 (range: 0.81–1.00) for the adult patients, and 0.86 ± 0.03 (range: 0.80–0.99) for the pediatric patients. Conclusion: The TWS Random Forest auto-segmentation algorithm was optimized for CT environment, and able to segment seven material classes over a range of body habitus and CT protocol parameters with an average DSC of 0.86 ± 0.04 (range: 0.80–0.99).

  6. SU-D-207A-01: Female Pelvic Synthetic CT Generation Based On Joint Shape and Intensity Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Liu, L; Jolly, S; Cao, Y; Vineberg, K; Fessler, J; Balter, J [University Michigan, Ann Arbor, MI (United States)

    2016-06-15

    Purpose: To develop a method for generating female pelvic synthetic CT (MRCT) images from a single MR scan and evaluate its utility in radiotherapy. Methods: Under IRB-approval, an imaging sequence (T1-VIBE-Dixon) was acquired for 10 patients. This sequence yields 3 useful image volumes of different contrast (“in-phase” T1-weighted, fat and water). A previously published pelvic bone shape model was used to generate a rough bone mask for each patient. A modified fuzzy c-means classification was performed on the multi spectral MR data, with a regularization term that utilizes the prior knowledge provided by the bone mask and addresses the intensity overlap between different tissue types. A weighted sum of classification probabilities with attenuation values yielded MRCT volumes. The mean absolute error (MAE) between MRCT and real CT on various regions was calculated following deformable alignment (Velocity). Intensity modulated Treatment plans based on actual CT and MRCT were made and compared. Results: The average/standard deviation of MAE across 10 patients was 10.1/6.7 HU for muscle, 6.7/4.6 HU for fat, 136.9/53.5 HU for bony tissues under 850 HU (97% of total bone volume), 188.9/119.3 HU for bony tissues above 850 HU and 17.3/13.3 HU for intrapelvic soft tissues. Calculated doses were comparable for plans generated on CT and calculated using MRCT densities or vice versa, with differences in PTV D99% (mean/σ) of (–0.1/0.2 Gy) and (0.3/0.2 Gy), PTV D0.5cc of (–0.3/0.2 Gy) and (–0.4/1.7 Gy). OAR differences were similarly small for comparable structures, with differences in bowel V50Gy of (–0.3/0.2%) and (0.0/0.2%), femur V30Gy of (0.7/1.2%) and (0.2/1.2%), sacrum V20GY of (0.0/0.1%) and (–0.1/1.1%) and mean pelvic V20Gy of (0.0/0.1%) and (0.6/1.8%). Conclusion: MRCT based on a single imaging sequence in the female pelvis is feasible, with acceptably small variations in attenuation estimates and calculated doses to target and critical organs. Work supported by NIHR01EB016079.

  7. SU-F-207-01: Comparison of Beam Characteristics and Organ Dose From Four Commercial Multidetector Computed Tomography Scanners

    Energy Technology Data Exchange (ETDEWEB)

    Ohno, T; Araki, F [Kumamoto University, Kumamoto, Kumamoto (Japan)

    2015-06-15

    Purpose: To compare dosimetric properties and patient organ doses from four commercial multidetector CT (MDCT) using Monte Carlo (MC) simulation based on the absorbed dose measured using a Farmer chamber and cylindrical water phantoms according to AAPM TG-111. Methods: Four commercial MDCT were modeled using the GMctdospp (IMPS, Germany) based on the EGSnrc user code. The incident photon spectrum and bowtie filter for MC simulations were determined so that calculated values of aluminum half-value layer (Al-HVL) and off-center ratio (OCR) profile in air agreed with measured values. The MC dose was calibrated from absorbed dose measurements using a Farmer chamber and cylindrical water phantoms. The dose distributions of head, chest, and abdominal scan were calculated using patient CT images and mean organ doses were evaluated from dose volume histograms. Results: The HVLs at 120 kVp of Brilliance, LightSpeed, Aquilion, and SOMATOM were 9.1, 7.5, 7.2, and 8.7 mm, respectively. The calculated Al-HVLs agreed with measurements within 0.3%. The calculated and measured OCR profiles agreed within 5%. For adult head scans, mean doses for eye lens from Brilliance, LightSpeed, Aquilion, and SOMATOM were 21.7, 38.5, 47.2 and 28.4 mGy, respectively. For chest scans, mean doses for lung from Brilliance, LightSpeed, Aquilion, and SOMATOM were 21.1, 26.1, 35.3 and 24.0 mGy, respectively. For adult abdominal scans, the mean doses for liver from Brilliance, LightSpeed, Aquilion, and SOMATOM were 16.5, 21.3, 22.7, and 18.0 mGy, respectively. The absorbed doses increased with decreasing Al-HVL. The organ doses from Aquilion were two greater than those from Brilliance in head scan. Conclusion: MC dose distributions based on absorbed dose measurement in cylindrical water phantom are useful to evaluate individual patient organ doses.

  8. TU-CD-207-02: Quantification of Breast Lesion Compositions Using Low-Dose Spectral Mammography: A Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Cho, H; Ding, H; Sennung, D; Kumar, N; Molloi, S [Department of Radiological Sciences, University of California, Irvine, CA (United States)

    2015-06-15

    Purpose: To investigate the feasibility of measuring breast lesion composition with spectral mammography using physical phantoms and bovine tissue. Methods: Phantom images were acquired with a spectral mammography system with a silicon-strip based photon-counting detector. Plastic water and adipose-equivalent phantoms were used to calibrate the system for dual-energy material decomposition. The calibration phantom was constructed in range of 2–8 cm thickness and water densities in the range of 0% to 100%. A non-linear rational fitting function was used to calibrate the imaging system. The phantom studies were performed with uniform background phantom and non-uniform background phantom. The breast lesion phantoms (2 cm in diameter and 0.5 cm in thickness) were made with water densities ranging from 0 to 100%. The lesion phantoms were placed in different positions and depths on the phantoms to investigate the accuracy of the measurement under various conditions. The plastic water content of the lesion was measured by subtracting the total decomposed plastic water signal from a surrounding 2.5 mm thick border outside the lesion. In addition, bovine tissue samples composed of 80 % lean were imaged as background for the simulated lesion phantoms. Results: The thickness of measured and known water contents was compared. The rootmean-square (RMS) errors in water thickness measurements were 0.01 cm for the uniform background phantom, 0.04 cm for non-uniform background phantom, and 0.03 cm for 80% lean bovine tissue background. Conclusion: The results indicate that the proposed technique using spectral mammography can be used to accurately characterize breast lesion compositions.

  9. TU-EF-207-03: Advances in Stationary Breast Tomosynthesis Using Distributed X-Ray Sources

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, O. [The University of North Carolina at Chapel Hill (United States)

    2015-06-15

    Breast imaging technology is advancing on several fronts. In digital mammography, the major technological trend has been on optimization of approaches for performing combined mammography and tomosynthesis using the same system. In parallel, photon-counting slot-scan mammography is now in clinical use and more efforts are directed towards further development of this approach for spectral imaging. Spectral imaging refers to simultaneous acquisition of two or more energy-windowed images. Depending on the detector and associated electronics, there are a number of ways this can be accomplished. Spectral mammography using photon-counting detectors can suppress electronic noise and importantly, it enables decomposition of the image into various material compositions of interest facilitating quantitative imaging. Spectral imaging can be particularly important in intravenously injected contrast mammography and eventually tomosynthesis. The various approaches and applications of spectral mammography are discussed. Digital breast tomosynthesis relies on the mechanical movement of the x-ray tube to acquire a number of projections in a predefined arc, typically from 9 to 25 projections over a scan angle of +/−7.5 to 25 degrees depending on the particular system. The mechanical x-ray tube motion requires relatively long acquisition time, typically between 3.7 to 25 seconds depending on the system. Moreover, mechanical scanning may have an effect on the spatial resolution due to internal x-ray filament or external mechanical vibrations. New x-ray source arrays have been developed and they are aimed at replacing the scanned x-ray tube for improved acquisition time and potentially for higher spatial resolution. The potential advantages and challenges of this approach are described. Combination of digital mammography and tomosynthesis in a single system places increased demands on certain functional aspects of the detector and overall performance, particularly in the tomosynthesis mode due to lower photon fluence per projection. This may require fast-frame acquisition and symmetric or asymmetric pixel binning in some systems. Recent studies investigated the performance of increased conversion layer thickness for contrast-enhanced imaging of the breast in dual-energy acquisition mode. In other direct conversion detectors operating in the avalanche mode, sensitivities close to the single photon response are also explored for mammography and breast tomosynthesis. The potential advantages and challenges of this approach are described. Dedicated breast CT brings x-ray imaging of the breast to true tomographic 3D imaging. It can eliminate the tissue superposition problem and does not require physical compression of the breast. Using cone beam geometry and a flat-panel detector, several hundred projections are acquired and reconstructed to near isotropic voxels. Multiplanar reconstruction facilitates viewing the breast volume in any desired orientation. Ongoing clinical studies, the current state-of-the art, and research to advance the technology are described. Learning Objectives: To understand the ongoing developments in x-ray imaging of the breast To understand the approaches and applications of spectral mammography To understand the potential advantages of distributed x-ray source arrays for digital breast tomosynthesis To understand the ongoing developments in detector technology for digital mammography and breast tomosynthesis To understand the current state-of-the-art for dedicated cone-beam breast CT and research to advance the technology. Research collaboration with Koning Corporation.

  10. TU-CD-207-08: Intrinsic Image Quality Comparison of Synthesized 2-D and FFDM Images

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, J; Wells, J; Samei, E [Clinical Imaging Physics Group, Duke University Medical Center, Durham, NC (United States)

    2015-06-15

    Purpose: With the combined interest of managing patient dose, maintaining or improving image quality, and maintaining or improving the diagnostic utility of mammographic data, this study aims to compare the intrinsic image quality of Hologic’s synthesized 2-D (C-View) and 2-D FFDM images in terms of resolution, contrast, and noise. Methods: This study utilized a novel 3-D printed anthropomorphic breast phantom in addition to the American College of Radiology (ACR) mammography accreditation phantom. Analysis of the 3-D anthropomorphic phantom included visual assessment of resolution and analysis of the normalized noise power spectrum. Analysis of the ACR phantom included both visual inspection and objective automated analysis using in-house software. The software incorporates image- and object-specific CNR visibility thresholds which account for image characteristics such as noise texture which affect object visualization. T- test statistical analysis was also performed on ACR phantom scores. Results: The spatial resolution of C-View images is markedly lower (at least 50% worse) than that of FFDM. And while this is generally associated with the benefit of reduced relative noise magnitude, the noise in C-View images tends to have a more mottled (predominantly low-frequency) texture. In general, for high contrast objects, C-View provides superior visualization over FFDM; however this benefit diminishes for low contrast objects and is applicable only to objects that are sufficiently larger than the spatial resolution threshold. Based on both observer and automated ACR phantom analysis, between 50–70% of C-View images failed to meet ACR minimum accreditation requirements – primarily due to insufficient (unbroken) fiber visibility. Conclusion: Compared to FFDM, C-View offers better depiction of objects of certain size and contrast, but provides poorer overall resolution and noise properties. Based on these findings, the utilization of C-View images in the clinical setting requires careful consideration, especially if considering the discontinuation of FFDM imaging.

  11. Physical therapy in relation to gait and balance in elderly women - doi:10.5020/18061230.2011.p207

    Directory of Open Access Journals (Sweden)

    Anniele Martins Silva

    2012-01-01

    Full Text Available Objective: To determine if there is a benefit of physical therapy intervention in relation to balance and gait in the elderly. Methods: An interventional study held in 2009 in Caruaru-PE, Brazil, evaluated elderly women aged 60 and 82 years, randomly divided into two groups, control and intervention, undergoing physical therapy assessment (posture, balance and mobility through Timed Get Up and Go Test scorings- TUG, analysis of socio-demographic profile (age, sex, history of falls, fear of falling, physical activity, smoking and drinking and physical therapy intervention for 10 weeks. Statistical analysis included chi-square test, Fisher’s exact and ANOVA. Results: We found that the risk of falls was more evident in the control group (p <0.05 regarding to the scores and rankings obtained in the TUG test. After the intervention, no participant in the experimental group reported fear of falling, and no longer reported the presence of pain. Conclusion: Physical therapy achieved through stretching exercises and training of balance and strength brought benefits to both the balance and the gait of the studied sample.

  12. 207 EFFICIENT GENERATION OF MYOSTATIN PROMOTER MUTATIONS IN BOVINE EMBRYOS USING THE CRISPR/Cas9 SYSTEM.

    Science.gov (United States)

    Pinzon, C A; Snyder, M; Pryor, J; Thompson, B; Golding, M; Long, C

    2016-01-01

    The myostatin gene or growth differentiation factor 8 is a member of the transforming growth factor-β superfamily that acts as a negative regulator of muscle growth. Mutations inactivating this gene occur naturally in Piedmontese and Belgian Blue cattle breeds, resulting in a dramatic increase in muscle mass, albeit with unwanted consequences of increased dystocia and decreased fertility. Modulation of muscle mass increase without the unwanted effects would be of great value for improving livestock growth and economic value of livestock. The objective of our work was to use the CRISPR-Cas9 genetic engineering tool to generate deletions of different elements in the myostatin promoter in order to decrease the level of expression and obtain an attenuated phenotype without the detrimental consequences of an inactivating mutation. To achieve this objective 4 different small guide RNA (sgRNA) targeting the promoter near the mutation were designed with PAM positions from transcription starting site of -1577, -689, -555, and -116. These sgRNA were cloned individually into the Cas9 plasmids (px461, and px462; Addgene®). These plasmids allow for a dual puromycin resistance (px462) and green fluorescent protein (px461) selection. We first tested the functionality of these sgRNA in vitro by co-transfecting bovine fetal fibroblasts with a combination of both plasmids (Set 1=sgRNA 1-4; Set 2=sgRNA 2-3). Cells were exposed to puromycin (0.2µgmL(-1)) for 72h, then single and mixed colonies positive for green fluorescent protein expression were separated for propagation. The DNA was extracted for PCR amplification of the targeted region. Multiple deletions and a few insertion events were observed after PCR, bands were cloned into TOPO® vector (Thermo Fisher Scientific, Waltham, MA, USA) and sequenced. Sequencing results confirmed the PCR products as insertions or deletions in the myostatin promoter region. We proceeded to modify the myostatin promoter directly in bovine zygotes. For this, IVF-derived zygotes were randomly assigned to 3 different treatment groups Set 1, Set 2, or Null (no sgRNA) for microinjections. Each zygote was injected with ~100 pL of trophectoderm buffer containing 50ngµL(-1) of total sgRNA, 10ngµL(-1) of Cas9 mRNA, and 30ngµL(-1) of Cas9 protein with 1mgmL(-1) of fluorescent dextran. Day 7 post-IVF blastocysts were lysed and DNA was extracted for PCR amplification of the target region. In Set 1, 16 of 19 embryos (94.12%) were successfully edited, whereas in Set 2 there were 11 of 17 embryos (64.7%) edited. In both sets of sgRNA there was a high degree of mosaicism, with only 1 embryo demonstrating a homozygous deletion. In conclusion, CRISPR/Cas9 acts over the course of the first few cleavage divisions Further research is necessary to refine the CRISPR/Cas9 system for inducing genetic mutations in bovine embryos.

  13. 33 CFR 207.640 - Sacramento Deep Water Ship Channel Barge Lock and Approach Canals; use, administration, and...

    Science.gov (United States)

    2010-07-01

    ... movement and position of all water traffic while at or near the locks and in the barge canals. (2... be raced or crowded alongside another in the barge canals. When entering the barge canals and...

  14. WE-G-207-05: Relationship Between CT Image Quality, Segmentation Performance, and Quantitative Image Feature Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J; Nishikawa, R [University of Pittsburgh, Pittsburgh, PA (United States); Reiser, I [The University of Chicago, Chicago, IL (United States); Boone, J [UC Davis Medical Center, Sacramento, CA (United States)

    2015-06-15

    Purpose: Segmentation quality can affect quantitative image feature analysis. The objective of this study is to examine the relationship between computed tomography (CT) image quality, segmentation performance, and quantitative image feature analysis. Methods: A total of 90 pathology proven breast lesions in 87 dedicated breast CT images were considered. An iterative image reconstruction (IIR) algorithm was used to obtain CT images with different quality. With different combinations of 4 variables in the algorithm, this study obtained a total of 28 different qualities of CT images. Two imaging tasks/objectives were considered: 1) segmentation and 2) classification of the lesion as benign or malignant. Twenty-three image features were extracted after segmentation using a semi-automated algorithm and 5 of them were selected via a feature selection technique. Logistic regression was trained and tested using leave-one-out-cross-validation and its area under the ROC curve (AUC) was recorded. The standard deviation of a homogeneous portion and the gradient of a parenchymal portion of an example breast were used as an estimate of image noise and sharpness. The DICE coefficient was computed using a radiologist’s drawing on the lesion. Mean DICE and AUC were used as performance metrics for each of the 28 reconstructions. The relationship between segmentation and classification performance under different reconstructions were compared. Distributions (median, 95% confidence interval) of DICE and AUC for each reconstruction were also compared. Results: Moderate correlation (Pearson’s rho = 0.43, p-value = 0.02) between DICE and AUC values was found. However, the variation between DICE and AUC values for each reconstruction increased as the image sharpness increased. There was a combination of IIR parameters that resulted in the best segmentation with the worst classification performance. Conclusion: There are certain images that yield better segmentation or classification performance. The best segmentation Result does not necessarily lead to the best classification Result. This work has been supported in part by grants from the NIH R21-EB015053. R Nishikawa is receives royalties form Hologic, Inc.

  15. 33 CFR 207.300 - Ohio River, Mississippi River above Cairo, Ill., and their tributaries; use, administration, and...

    Science.gov (United States)

    2010-07-01

    ... District Engineer and market by signs and/or flashing red lights installed in conspicuous and appropriate... or habitations; terrestrial growth such as trees and bushes; and man-made amenities that may be...-hand side (facing downstream) of the river and a black can-type buoy for such structures located on...

  16. Vol. 4(1), S/No 13, January, 2015:207-223 ISSN: 2225-8590 (Print ...

    African Journals Online (AJOL)

    DR Nneka

    2015-01-13

    Jan 13, 2015 ... Issues on the Gagging of Nigerian Press with Obnoxious Laws .... during the military rule in Nigeria through the use of obnoxious decrees. ... functionaries and the instruments of control were: heavy taxation, repressive laws,.

  17. 33 CFR 207.160 - All waterways tributary to the Atlantic Ocean south of Chesapeake Bay and all waterways tributary...

    Science.gov (United States)

    2010-07-01

    ..., bridges, piers, fences, trees, houses, shops or any other property of the United States pertaining to the..., house boats or like craft shall be expedited by locking them through with commercial craft (other than... by written permit from the District Engineer. (8) The building, assembling, or breaking up of a...

  18. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Science.gov (United States)

    2010-01-01

    ... Category 1(TBq) Category 1(Ci) Category 2(TBq) Category 2(Ci) Actinium-227 20 540 0.2 5.4 Americium-241 60... 2 54 Strontium-90 1,000 27,000 10 270 Thorium-228 20 540 0.2 5.4 Thorium-229 20 540 0.2 5.4...

  19. I. The metabolic properties of plutonium and allied materials

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  20. Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.

    Science.gov (United States)

    Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R; Wai, Chien M

    1999-09-01

    A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

  1. WE-EF-207-01: FEATURED PRESENTATION and BEST IN PHYSICS (IMAGING): Task-Driven Imaging for Cone-Beam CT in Interventional Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Gang, G; Stayman, J; Ouadah, S; Siewerdsen, J [Johns Hopkins University, Baltimore, MD (United States); Ehtiati, T [Siemens Healthcare AX Division, Erlangen, DE (Germany)

    2015-06-15

    Purpose: This work introduces a task-driven imaging framework that utilizes a patient-specific anatomical model, mathematical definition of the imaging task, and a model of the imaging system to prospectively design acquisition and reconstruction techniques that maximize task-based imaging performance. Utility of the framework is demonstrated in the joint optimization of tube current modulation and view-dependent reconstruction kernel in filtered-backprojection reconstruction and non-circular orbit design in model-based reconstruction. Methods: The system model is based on a cascaded systems analysis of cone-beam CT capable of predicting the spatially varying noise and resolution characteristics as a function of the anatomical model and a wide range of imaging parameters. Detectability index for a non-prewhitening observer model is used as the objective function in a task-driven optimization. The combination of tube current and reconstruction kernel modulation profiles were identified through an alternating optimization algorithm where tube current was updated analytically followed by a gradient-based optimization of reconstruction kernel. The non-circular orbit is first parameterized as a linear combination of bases functions and the coefficients were then optimized using an evolutionary algorithm. The task-driven strategy was compared with conventional acquisitions without modulation, using automatic exposure control, and in a circular orbit. Results: The task-driven strategy outperformed conventional techniques in all tasks investigated, improving the detectability of a spherical lesion detection task by an average of 50% in the interior of a pelvis phantom. The non-circular orbit design successfully mitigated photon starvation effects arising from a dense embolization coil in a head phantom, improving the conspicuity of an intracranial hemorrhage proximal to the coil. Conclusion: The task-driven imaging framework leverages a knowledge of the imaging task within a patient-specific anatomical model to optimize image acquisition and reconstruction techniques, thereby improving imaging performance beyond that achievable with conventional approaches. 2R01-CA-112163; R01-EB-017226; U01-EB-018758; Siemens Healthcare (Forcheim, Germany)

  2. SU-F-207-07: Dual-Energy Computed Tomography Detection Limit of Various Radiopaque Contrast Agents That Can Be Infused Within Absorbable Inferior Vena Cava Filters

    Energy Technology Data Exchange (ETDEWEB)

    Melancon, A; Jacobsen, M; Salatan, F; Jones, A; Cody, D; Nute, J; Melancon, M [U.T.M.D Anderson Cancer Center, Houston, TX (United States)

    2015-06-15

    Purpose: Absorbable IVC filters are shown to be safe and efficacious in preventing pulmonary embolism. These absorbable filters disappear from the body after their required duration, alleviating costly removal procedures and downstream complications. Monitoring the positioning and integrity of absorbable devices using dual-energy computed tomography (DECT) would improve treatment efficacy. The purpose of this study is to determine the limit of detection and the energy dependence of DECT for various contrast agents that may be infused within the IVC filters including gold nanoparticles (AuNP) having diameters of 2 and 4 nm. Methods: All imaging studies were performed on a GE Discovery CT750 system in Gemstone Spectral Imaging (GSI) mode. Plastic vials containing the contrast agent solutions of water and blood were placed in a water bath, and images were acquired with the GSI-5 preset. The images were reformatted into the coronal plane and 5mm diameter ROIs were placed within each solution on a GE Advantage Workstation. Monoenergetic reconstructions were generated from 40 – 140 keV. Results: Mass attenuation (contrast per unit density) for AuNPs was greater than iron, but less than barium and iodine. Contrast was 10.2 (± 3.6) HU for 4 nm AuNP at 0.72 mg/ml and 12.1 (± 4.2) for 2 nm AuNP at 0.31 mg/ml at 70 keV suggesting reasonable chance of visualization at these concentrations for 70 keV reconstruction. The contrast as a function of CT energy is similar in both water and blood. Iodine is most dependent, followed closely by barium and iron, and trailed by a large margin by the AuNP. This was unexpected given Au’s large atomic number and the predominance of photoelectric effect at low energy. Conclusion: Infusion of IVC filters with AuNP is feasible. Discrimination of AuNP-infused IVC filters from surrounding anatomy warrants further investigation.

  3. WE-DE-207A-02: Advances in Cone Beam CT Anatomical and Functional Imaging in Angio-Suite to Enable One-Stop-Shop Stroke Imaging Workflow.

    Science.gov (United States)

    Chen, G

    2016-06-01

    1. Parallels in the evolution of x-ray angiographic systems and devices used for minimally invasive endovascular therapy Charles Strother - DSA, invented by Dr. Charles Mistretta at UW-Madison, was the technology which enabled the development of minimally invasive endovascular procedures. As DSA became widely available and the potential benefits for accessing the cerebral vasculature from an endovascular approach began to be apparent, industry began efforts to develop tools for use in these procedures. Along with development of catheters, embolic materials, pushable coils and the GDC coils there was simultaneous development and improvement of 2D DSA image quality and the introduction of 3D DSA. Together, these advances resulted in an enormous expansion in the scope and numbers of minimally invasive endovascular procedures. The introduction of flat detectors for c-arm angiographic systems in 2002 provided the possibility of the angiographic suite becoming not just a location for vascular imaging where physiological assessments might also be performed. Over the last decade algorithmic and hardware advances have been sufficient to now realize this potential in clinical practice. The selection of patients for endovascular treatments is enhanced by this dual capability. Along with these advances has been a steady reduction in the radiation exposure required so that today, vascular and soft tissue images may be obtained with equal or in many cases less radiation exposure than is the case for comparable images obtained with multi-detector CT.

  4. SU-C-207-04: Reconstruction Artifact Reduction in X-Ray Cone Beam CT Using a Treatment Couch Model

    Energy Technology Data Exchange (ETDEWEB)

    Lasio, G; Hu, E; Zhou, J; Lee, M; Yi, B [University of Maryland School of Medicine, Baltimore, MD (United States)

    2015-06-15

    Purpose: to mitigate artifacts induced by the presence of the RT treatment couch in on-board CBCT and improve image quality Methods: a model of a Varian IGRT couch is constructed using a CBCT scan of the couch in air. The model is used to generate a set of forward projections (FP) of the treatment couch at specified gantry angles. The model couch forward projections are then used to process CBCT scan projections which contain the couch in addition to the scan object (Catphan phantom), in order to remove the attenuation component of the couch at any given gantry angle. Prior to pre-processing with the model FP, the Catphan projection data is normalized to an air scan with bowtie filter. The filtered Catphan projections are used to reconstruct the CBCT with an in-house FDK algorithm. The artifact reduction in the processed CBCT scan is assessed visually, and the image quality improvement is measured with the CNR over a few selected ROIs of the Catphan modules. Results: Sufficient match between the forward projected data and the x-ray projections is achieved to allow filtering in attenuation space. Visual improvement of the couch induced artifacts is achieved, with a moderate expense of CNR. Conclusion: Couch model-based correction of CBCT projection data has a potential for qualitative improvement of clinical CBCT scans, without requiring position specific correction data. The technique could be used to produce models of other artifact inducing devices, such as immobilization boards, and reduce their impact on patient CBCT images.

  5. SU-D-207-03: Development of 4D-CBCT Imaging System with Dual Source KV X-Ray Tubes

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, M; Ishihara, Y; Matsuo, Y; Ueki, N; Iizuka, Y; Mizowaki, T; Hiraoka, M [Kyoto University Hospital, Kyoto, Kyoto (Japan)

    2015-06-15

    Purpose: The purposes of this work are to develop 4D-CBCT imaging system with orthogonal dual source kV X-ray tubes, and to determine the imaging doses from 4D-CBCT scans. Methods: Dual source kV X-ray tubes were used for the 4D-CBCT imaging. The maximum CBCT field of view was 200 mm in diameter and 150 mm in length, and the imaging parameters were 110 kV, 160 mA and 5 ms. The rotational angle was 105°, the rotational speed of the gantry was 1.5°/s, the gantry rotation time was 70 s, and the image acquisition interval was 0.3°. The observed amplitude of infrared marker motion during respiration was used to sort each image into eight respiratory phase bins. The EGSnrc/BEAMnrc and EGSnrc/DOSXYZnrc packages were used to simulate kV X-ray dose distributions of 4D-CBCT imaging. The kV X-ray dose distributions were calculated for 9 lung cancer patients based on the planning CT images with dose calculation grid size of 2.5 x 2.5 x 2.5 mm. The dose covering a 2-cc volume of skin (D2cc), defined as the inner 5 mm of the skin surface with the exception of bone structure, was assessed. Results: A moving object was well identified on 4D-CBCT images in a phantom study. Given a gantry rotational angle of 105° and the configuration of kV X-ray imaging subsystems, both kV X-ray fields overlapped at a part of skin surface. The D2cc for the 4D-CBCT scans was in the range 73.8–105.4 mGy. Linear correlation coefficient between the 1000 minus averaged SSD during CBCT scanning and D2cc was −0.65 (with a slope of −0.17) for the 4D-CBCT scans. Conclusion: We have developed 4D-CBCT imaging system with dual source kV X-ray tubes. The total imaging dose with 4D-CBCT scans was up to 105.4 mGy.

  6. SU-C-207-06: In Vivo Quantification of Gold Nanoparticles Using K-Edge Imaging Via Spectrum Shaping by Gold Filter

    Energy Technology Data Exchange (ETDEWEB)

    Chen, H; Cormack, R; Bhagwat, M; Berbeco, R [Brigham and Women’s Hospital, Boston, MA (United States)

    2015-06-15

    Purpose: Gold nanoparticles (AuNP) are multifunctional platforms ideal for drug delivery, targeted imaging and radiosensitization. We have investigated quantitative imaging of AuNPs using on board imager (OBI) cone beam computed tomography (CBCT). To this end, we also present, for the first time, a novel method for k-edge imaging of AuNP by filter-based spectral shaping. Methods: We used a digital 25 cm diameter water phantom, embedded with 3 cm spheres filled with AuNPs of different concentrations (0 mg/ml – 16 mg/ml). A poly-energetic X-ray spectrum of 140 kVp from a conventional X-ray tube is shaped by balanced K-edge filters to create an excess of photons right above the K-edge of gold at 80.7 keV. The filters consist of gold, tin, copper and aluminum foils. The phantom with appropriately assigned attenuation coefficients is forward projected onto a detector for each energy bin and then integrated. FKD reconstruction is performed on the integrated projections. Scatter, detector efficiency and noise are included. Results: We found that subtracting the results of two filter sets (Filter A:127 µm gold foil with 254 µm tin, 330 µm copper and 1 mm aluminum, and Filter B: 635 µm tin with 264 µm copper and 1 mm aluminum), provides substantial image contrast. The resulting filtered spectra match well below 80.7 keV, while maintaining sufficient X-ray quanta just above that. Voxel intensities of AuNP containing spheres increase linearly with AuNP concentration. K-edge imaging provides 18% more sensitivity than the tin filter alone, and 38% more sensitivity than the gold filter alone. Conclusion: We have shown that it is feasible to quantitatively detect AuNP distributions in a patient-sized phantom using clinical CBCT and K-edge spectral shaping.

  7. SU-C-207-05: A Comparative Study of Noise-Reduction Algorithms for Low-Dose Cone-Beam Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Mukherjee, S; Yao, W [St. Jude Children’s Research Hospital, Memphis, TN (United States)

    2015-06-15

    Purpose: To study different noise-reduction algorithms and to improve the image quality of low dose cone beam CT for patient positioning in radiation therapy. Methods: In low-dose cone-beam CT, the reconstructed image is contaminated with excessive quantum noise. In this study, three well-developed noise reduction algorithms namely, a) penalized weighted least square (PWLS) method, b) split-Bregman total variation (TV) method, and c) compressed sensing (CS) method were studied and applied to the images of a computer–simulated “Shepp-Logan” phantom and a physical CATPHAN phantom. Up to 20% additive Gaussian noise was added to the Shepp-Logan phantom. The CATPHAN phantom was scanned by a Varian OBI system with 100 kVp, 4 ms and 20 mA. For comparing the performance of these algorithms, peak signal-to-noise ratio (PSNR) of the denoised images was computed. Results: The algorithms were shown to have the potential in reducing the noise level for low-dose CBCT images. For Shepp-Logan phantom, an improvement of PSNR of 2 dB, 3.1 dB and 4 dB was observed using PWLS, TV and CS respectively, while for CATPHAN, the improvement was 1.2 dB, 1.8 dB and 2.1 dB, respectively. Conclusion: Penalized weighted least square, total variation and compressed sensing methods were studied and compared for reducing the noise on a simulated phantom and a physical phantom scanned by low-dose CBCT. The techniques have shown promising results for noise reduction in terms of PSNR improvement. However, reducing the noise without compromising the smoothness and resolution of the image needs more extensive research.

  8. SU-C-207-02: A Method to Estimate the Average Planar Dose From a C-Arm CBCT Acquisition

    Energy Technology Data Exchange (ETDEWEB)

    Supanich, MP [Rush University Medical Center, Chicago, IL (United States)

    2015-06-15

    Purpose: The planar average dose in a C-arm Cone Beam CT (CBCT) acquisition had been estimated in the past by averaging the four peripheral dose measurements in a CTDI phantom and then using the standard 2/3rds peripheral and 1/3 central CTDIw method (hereafter referred to as Dw). The accuracy of this assumption has not been investigated and the purpose of this work is to test the presumed relationship. Methods: Dose measurements were made in the central plane of two consecutively placed 16cm CTDI phantoms using a 0.6cc ionization chamber at each of the 4 peripheral dose bores and in the central dose bore for a C-arm CBCT protocol. The same setup was scanned with a circular cut-out of radiosensitive gafchromic film positioned between the two phantoms to capture the planar dose distribution. Calibration curves for color pixel value after scanning were generated from film strips irradiated at different known dose levels. The planar average dose for red and green pixel values was calculated by summing the dose values in the irradiated circular film cut out. Dw was calculated using the ionization chamber measurements and film dose values at the location of each of the dose bores. Results: The planar average dose using both the red and green pixel color calibration curves were within 10% agreement of the planar average dose estimated using the Dw method of film dose values at the bore locations. Additionally, an average of the planar average doses calculated using the red and green calibration curves differed from the ionization chamber Dw estimate by only 5%. Conclusion: The method of calculating the planar average dose at the central plane of a C-arm CBCT non-360 rotation by calculating Dw from peripheral and central dose bore measurements is a reasonable approach to estimating the planar average dose. Research Grant, Siemens AG.

  9. SU-D-207-05: Real-Time Intrafractional Motion Tracking During VMAT Delivery Using a Conventional Elekta CBCT System

    Energy Technology Data Exchange (ETDEWEB)

    Park, Yang-Kyun; Sharp, Gregory C.; Gierga, David P.; Winey, Brian A. [Massachusetts General Hospital, Boston, MA (United States); Ye, Sung-Joon [Seoul National University, Seoul (Korea, Republic of)

    2015-06-15

    Purpose: Real-time kV projection streaming capability has become recently available for Elekta XVI version 5.0. This study aims to investigate the feasibility and accuracy of real-time fiducial marker tracking during CBCT acquisition with or without simultaneous VMAT delivery using a conventional Elekta linear accelerator. Methods: A client computer was connected to an on-board kV imaging system computer, and receives and processes projection images immediately after image acquisition. In-house marker tracking software based on FFT normalized cross-correlation was developed and installed in the client computer. Three gold fiducial markers with 3 mm length were implanted in a pelvis-shaped phantom with 36 cm width. The phantom was placed on a programmable motion platform oscillating in anterior-posterior and superior-inferior directions simultaneously. The marker motion was tracked in real-time for (1) a kV-only CBCT scan with treatment beam off and (2) a kV CBCT scan during a 6-MV VMAT delivery. The exposure parameters per projection were 120 kVp and 1.6 mAs. Tracking accuracy was assessed by comparing superior-inferior positions between the programmed and tracked trajectories. Results: The projection images were successfully transferred to the client computer at a frequency of about 5 Hz. In the kV-only scan, highly accurate marker tracking was achieved over the entire range of cone-beam projection angles (detection rate / tracking error were 100.0% / 0.6±0.5 mm). In the kV-VMAT scan, MV-scatter degraded image quality, particularly for lateral projections passing through the thickest part of the phantom (kV source angle ranging 70°-110° and 250°-290°), resulting in a reduced detection rate (90.5%). If the lateral projections are excluded, tracking performance was comparable to the kV-only case (detection rate / tracking error were 100.0% / 0.8±0.5 mm). Conclusion: Our phantom study demonstrated a promising Result for real-time motion tracking using a conventional Elekta linear accelerator. MV-scatter suppression is needed to improve tracking accuracy during MV delivery. This research is funded by Motion Management Research Grant from Elekta.

  10. SU-D-207-07: Implementation of Full/half Bowtie Filter Model in a Commercial Treatment Planning System for Kilovoltage X-Ray Imaging Dose Estimation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S [Advocate Lutheran General Hospital, Park Ridge, IL (United States); Alaei, P [Univ Minnesota, Minneapolis, MN (United States)

    2015-06-15

    Purpose: To implement full/half bowtie filter models in a commercial treatment planning system (TPS) to calculate kilovoltage (kV) x-ray imaging dose of Varian On-Board Imager (OBI) cone beam CT (CBCT) system. Methods: Full/half bowtie filters of Varian OBI were created as compensator models in Pinnacle TPS (version 9.6) using Matlab software (version 2011a). The profiles of both bowtie filters were acquired from the manufacturer, imported into the Matlab system and hard coded in binary file format. A Pinnacle script was written to import each bowtie filter data into a Pinnacle treatment plan as a compensator. A kV x-ray beam model without including the compensator model was commissioned per each bowtie filter setting based on percent depth dose and lateral profile data acquired from Monte Carlo simulations. To validate the bowtie filter models, a rectangular water phantom was generated in the planning system and an anterior/posterior beam with each bowtie filter was created. Using the Pinnacle script, each bowtie filter compensator was added to the treatment plan. Lateral profile at the depth of 3cm and percent depth dose were measured using an ion chamber and compared with the data extracted from the treatment plans. Results: The kV x-ray beams for both full and half bowtie filter have been modeled in a commercial TPS. The difference of lateral and depth dose profiles between dose calculations and ion chamber measurements were within 6%. Conclusion: Both full/half bowtie filter models provide reasonable results in kV x-ray dose calculations in the water phantom. This study demonstrates the possibility of using a model-based treatment planning system to calculate the kV imaging dose for both full and half bowtie filter modes. Further study is to be performed to evaluate the models in clinical situations.

  11. Mathis Wackernagel y William Rees, Nuestra huella ecológica: Reduciendo el impacto humano sobre la Tierra, IEP/Lom Ediciones, Santiago 2001, 207 p.

    OpenAIRE

    2012-01-01

    Monitoreando el sobregiro No es una buena práctica vivir con la cuenta sobregirada. Esto lo sabe todo buen empresario y dueña de casa. Si no, pregúntenle a quienes han visto sus casas y bienes embargados. Una escena dolorosa que se repite muy frecuentemente en nuestro país. Sin embargo, corremos un riesgo mayor que ese al sobregirar la cuenta ecológica del país, según un informe reciente de la Academia de Ciencias de Estados Unidos. Mathis Wackernagel, el director de la Fundación Redefining P...

  12. WE-B-207-02: CT Lung Cancer Screening and the Medical Physicist: A Dosimetry Summary of CT Participants in the National Lung Cancer Screening Trial (NLST)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, C. [National Cancer Institute (United States)

    2015-06-15

    The US National Lung Screening Trial (NLST) was a multi-center randomized, controlled trial comparing a low-dose CT (LDCT) to posterior-anterior (PA) chest x-ray (CXR) in screening older, current and former heavy smokers for early detection of lung cancer. Recruitment was launched in September 2002 and ended in April 2004 when 53,454 participants had been randomized at 33 screening sites in equal proportions. Funded by the National Cancer Institute this trial demonstrated that LDCT screening reduced lung cancer mortality. The US Preventive Services Task Force (USPSTF) cited NLST findings and conclusions in its deliberations and analysis of lung cancer screening. Under the 2010 Patient Protection and Affordable Care Act, the USPSTF favorable recommendation regarding lung cancer CT screening assisted in obtaining third-party payers coverage for screening. The objective of this session is to provide an introduction to the NLST and the trial findings, in addition to a comprehensive review of the dosimetry investigations and assessments completed using individual NLST participant CT and CXR examinations. Session presentations will review and discuss the findings of two independent assessments, a CXR assessment and the findings of a CT investigation calculating individual organ dosimetry values. The CXR assessment reviewed a total of 73,733 chest x-ray exams that were performed on 92 chest imaging systems of which 66,157 participant examinations were used. The CT organ dosimetry investigation collected scan parameters from 23,773 CT examinations; a subset of the 75,133 CT examinations performed using 97 multi-detector CT scanners. Organ dose conversion coefficients were calculated using a Monte Carlo code. An experimentally-validated CT scanner simulation was coupled with 193 adult hybrid computational phantoms representing the height and weight of the current U.S. population. The dose to selected organs was calculated using the organ dose library and the abstracted scan parameters. This session will review the results and summarize the individualized doses to major organs and the mean effective dose and CTDIvol estimate for 66,157 PA chest and 23,773 CT examinations respectively, using size-dependent computational phantoms coupled with Monte Carlo calculations. Learning Objectives: Review and summarize relevant NLST findings and conclusions. Understand the scope and scale of the NLST specific to participant dosimetry. Provide a comprehensive review of NLST participant dosimetry assessments. Summarize the results of an investigation providing individualized organ dose estimates for NLST participant cohorts.

  13. WE-B-207-01: CT Lung Cancer Screening and the Medical Physicist: Background, Findings and Participant Dosimetry Summary of the National Lung Screening Trial (NLST)

    Energy Technology Data Exchange (ETDEWEB)

    Kruger, R. [Marshfield Clinic, Marshfield, WI (United States)

    2015-06-15

    The US National Lung Screening Trial (NLST) was a multi-center randomized, controlled trial comparing a low-dose CT (LDCT) to posterior-anterior (PA) chest x-ray (CXR) in screening older, current and former heavy smokers for early detection of lung cancer. Recruitment was launched in September 2002 and ended in April 2004 when 53,454 participants had been randomized at 33 screening sites in equal proportions. Funded by the National Cancer Institute this trial demonstrated that LDCT screening reduced lung cancer mortality. The US Preventive Services Task Force (USPSTF) cited NLST findings and conclusions in its deliberations and analysis of lung cancer screening. Under the 2010 Patient Protection and Affordable Care Act, the USPSTF favorable recommendation regarding lung cancer CT screening assisted in obtaining third-party payers coverage for screening. The objective of this session is to provide an introduction to the NLST and the trial findings, in addition to a comprehensive review of the dosimetry investigations and assessments completed using individual NLST participant CT and CXR examinations. Session presentations will review and discuss the findings of two independent assessments, a CXR assessment and the findings of a CT investigation calculating individual organ dosimetry values. The CXR assessment reviewed a total of 73,733 chest x-ray exams that were performed on 92 chest imaging systems of which 66,157 participant examinations were used. The CT organ dosimetry investigation collected scan parameters from 23,773 CT examinations; a subset of the 75,133 CT examinations performed using 97 multi-detector CT scanners. Organ dose conversion coefficients were calculated using a Monte Carlo code. An experimentally-validated CT scanner simulation was coupled with 193 adult hybrid computational phantoms representing the height and weight of the current U.S. population. The dose to selected organs was calculated using the organ dose library and the abstracted scan parameters. This session will review the results and summarize the individualized doses to major organs and the mean effective dose and CTDIvol estimate for 66,157 PA chest and 23,773 CT examinations respectively, using size-dependent computational phantoms coupled with Monte Carlo calculations. Learning Objectives: Review and summarize relevant NLST findings and conclusions. Understand the scope and scale of the NLST specific to participant dosimetry. Provide a comprehensive review of NLST participant dosimetry assessments. Summarize the results of an investigation providing individualized organ dose estimates for NLST participant cohorts.

  14. SU-D-207B-04: Morphological Features of MRI as a Correlate of Capsular Contracture in Breast Cancer Patients with Implant-Based Reconstructions

    Energy Technology Data Exchange (ETDEWEB)

    Tyagi, N; Sutton, E; Hunt, M; Apte, A; Zhang, J; Oh, J; Mechalakos, J; Mehrara, B; Matros, E; Ho, A [Mem Sloan-Kettering Cancer Ctr, New York, NY (United States)

    2016-06-15

    Purpose: Capsular contracture (CC) is a serious complication in patients receiving implant-based reconstruction for breast cancer. The goal of this study was to identify image-based correlates of CC using MRI imaging in breast cancer patients who received both MRI and clinical evaluation following reconstructive surgery. Methods: We analyzed a retrospective dataset of 50 patients who had both a diagnostic MR and a plastic surgeon’s evaluations of CC score (Baker’s score) within a six month period following mastectomy and reconstructive surgery. T2w sagittal MRIs (TR/TE = 3500/102 ms, slice thickness = 4 mm) were used for morphological shape features (roundness, eccentricity, solidity, extent and ratio-length) and histogram features (median, skewness and kurtosis) of the implant and the pectoralis muscle overlying the implant. Implant and pectoralis muscles were segmented in 3D using Computation Environment for Radiological Research (CERR) and shape and histogram features were calculated as a function of Baker’s score. Results: Shape features such as roundness and eccentricity were statistically significant in differentiating grade 1 and grade 2 (p = 0.009; p = 0.06) as well as grade 1 and grade 3 CC (p = 0.001; p = 0.006). Solidity and extent were statistically significant in differentiating grade 1 and grade 3 CC (p = 0.04; p = 0.04). Ratio-length was statistically significant in differentiating all grades of CC except grade 2 and grade 3 that showed borderline significance (p = 0.06). The muscle thickness, median intensity and kurtosis were significant in differentiating between grade 1 and grade 3 (p = 0.02), grade 1 and grade 2 (p = 0.03) and grade 1 and grade 3 (p = 0.01) respectively. Conclusion: Morphological shape features described on MR images were associated with the severity of CC. MRI may be important in objectively evaluating outcomes in breast cancer patients who undergo implant reconstruction.

  15. A study of b anti b production in e{sup +}e{sup -} collisions at {radical}(s)=130 -207 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Abdallah, J.; Antilogus, P.; Augustin, J.E.; Baubillier, M.; Berggren, M.; Da Silva, W.; Kapusta, F.; Savoy-Navarro, A. [Univ. Paris VI et VII, LPNHE, IN2P3-CNRS, Paris Cedex 05 (France); Abreu, P.; Andringa, S.; Anjos, N.; Castro, N.; Espirito Santo, M.C.; Goncalves, P.; Moreno, S.; Onofre, A.; Peralta, L.; Pimenta, M.; Tome, B.; Veloso, F. [LIP, IST, FCUL, Lisboa Codex (Portugal); Adam, W.; Buschbeck, B.; Leder, G.; Liko, D.; MacNaughton, J.; Mandl, F.; Mitaroff, W.; Strauss, J. [Oesterr. Akad. d. Wissensch., Institut fuer Hochenergiephysik, Vienna (Austria); Adzic, P.; Fanourakis, G.; Kokkinias, P.; Loukas, D.; Markou, A.; Mastroyiannopoulos, N.; Nassiakou, M.; Tzamarias, S.; Zupan, M. [N.C.S.R. Demokritos, Institute of Nuclear Physics, P.O. Box 60228, Athens (Greece); Albrecht, T.; Allmendinger, T.; Apel, W.D.; Boer, W. de; Feindt, M.; Haag, C.; Hauler, F.; Hennecke, M.; Jungermann, L.; Kerzel, U.; Moch, M.; Rehn, J.; Sander, C.; Stanitzki, M.; Weiser, C. [Universitaet Karlsruhe, Institut fuer Experimentelle Kernphysik, Postfach 6980, Karlsruhe (Germany); Alemany-Fernandez, R.; Ask, S.; Augustinus, A.; Baillon, P.; Battaglia, M.; Camporesi, T.; Carena, F.; Charpentier, P.; Chierici, R.; Chudoba, J.; Chung, S.U.; Collins, P.; Elsing, M.; Foeth, H.; Gavillet, P.; Holt, P.J.; Joram, C.; Kjaer, N.J.; Marin, J.C.; Mariotti, C.; Pape, L.; Parzefall, U.; Piotto, E.; Poireau, V.; Rebecchi, P.; Schwickerath, U.; Spassov, T.; Treille, D.; Van Eldik, J.; Van Vulpen, I.; Wicke, D. [CERN, Geneva 23 (Switzerland); Allport, P.P.; Booth, P.S.L.; Bowcock, T.J.V.; Houlden, M.A.; Jackson, J.N.; King, B.T.; Mc Nulty, R.; Palacios, J.P.; Tobin, M.; Washbrook, A.J. [University of Liverpool, Department of Physics, P.O. Box 147, Liverpool (United Kingdom); Amaldi, U.; Bonesini, M.; Calvi, M.; Matteuzzi, C.; Paganoni, M.; Pullia, A.; Tabarelli, T.; Tonazzo, A. [Univ. di Milano-Bicocca (Italy); INFN-MILANO, Dipartimento di Fisica, Milan (Italy)] [and others

    2009-03-15

    Measurements are presented of R{sub b}, the ratio of the b anti b cross-section to the q anti q cross-section in e{sup +}e{sup -} collisions, and the forward-backward asymmetry A{sub FB}{sup b} at twelve energy points in the range {radical}(s)=130-07 GeV. These results are found to be consistent with the Standard Model expectations. The measurements are used to set limits on new physics scenarios involving contact interactions. (orig.) 2.

  16. WE-G-207-02: Full Sequential Projection Onto Convex Sets (FS-POCS) for X-Ray CT Reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Liu, L; Han, Y [Tianjin University, Tianjin (China); Jin, M [University of Texas at Arlington, Arlington, TX (United States)

    2015-06-15

    Purpose: To develop an iterative reconstruction method for X-ray CT, in which the reconstruction can quickly converge to the desired solution with much reduced projection views. Methods: The reconstruction is formulated as a convex feasibility problem, i.e. the solution is an intersection of three convex sets: 1) data fidelity (DF) set – the L2 norm of the difference of observed projections and those from the reconstructed image is no greater than an error bound; 2) non-negativity of image voxels (NN) set; and 3) piecewise constant (PC) set - the total variation (TV) of the reconstructed image is no greater than an upper bound. The solution can be found by applying projection onto convex sets (POCS) sequentially for these three convex sets. Specifically, the algebraic reconstruction technique and setting negative voxels as zero are used for projection onto the DF and NN sets, respectively, while the projection onto the PC set is achieved by solving a standard Rudin, Osher, and Fatemi (ROF) model. The proposed method is named as full sequential POCS (FS-POCS), which is tested using the Shepp-Logan phantom and the Catphan600 phantom and compared with two similar algorithms, TV-POCS and CP-TV. Results: Using the Shepp-Logan phantom, the root mean square error (RMSE) of reconstructed images changing along with the number of iterations is used as the convergence measurement. In general, FS- POCS converges faster than TV-POCS and CP-TV, especially with fewer projection views. FS-POCS can also achieve accurate reconstruction of cone-beam CT of the Catphan600 phantom using only 54 views, comparable to that of FDK using 364 views. Conclusion: We developed an efficient iterative reconstruction for sparse-view CT using full sequential POCS. The simulation and physical phantom data demonstrated the computational efficiency and effectiveness of FS-POCS.

  17. NEUTRON DECAY OF THE EXCITATION-ENERGY REGION UP TO 60 MEV, EXCITED BY HEAVY-ION SCATTERING .1. PB-207

    NARCIS (Netherlands)

    VANDENBERG, AM; CHMIELEWSKA, D; BORDEWIJK, JA; BRANDENBURG, S; VANDERWOUDE, A; BLUMENFELD, Y; FRASCARIA, N; ROYNETTE, JC; SCARPACI, JA; SUOMIJARVI, T; ALAMANOS, N; AUGER, F; GILLIBERT, A; ROUSSELCHOMAZ, P; BLOMGREN, J; NILSSON, L; OLSSON, N; TURCOTTE, R

    1994-01-01

    The neutron decay of the continuum in Pb-208, excited by small-angle inelastic scattering of 84 MeV/nucleon O-17 ions in the range from 1.5-degrees, to 4.5-degrees, has been measured. Statistical decay was found to dominate the excitation-energy interval studied, up to 60 MeV. In the excitation-ener

  18. SU-C-207-03: Optimization of a Collimator-Based Sparse Sampling Technique for Low-Dose Cone-Beam CT

    Energy Technology Data Exchange (ETDEWEB)

    Lee, T; Cho, S [KAIST, Daejon (Korea, Republic of); Kim, I; Han, B [EB Tech Co., Ltd., Daejeon (Korea, Republic of)

    2015-06-15

    Purpose: In computed tomography (CT) imaging, radiation dose delivered to the patient is one of the major concerns. Sparse-view CT takes projections at sparser view angles and provides a viable option to reducing dose. However, a fast power switching of an X-ray tube, which is needed for the sparse-view sampling, can be challenging in many CT systems. We have earlier proposed a many-view under-sampling (MVUS) technique as an alternative to sparse-view CT. In this study, we investigated the effects of collimator parameters on the image quality and aimed to optimize the collimator design. Methods: We used a bench-top circular cone-beam CT system together with a CatPhan600 phantom, and took 1440 projections from a single rotation. The multi-slit collimator made of tungsten was mounted on the X-ray source for beam blocking. For image reconstruction, we used a total-variation minimization (TV) algorithm and modified the backprojection step so that only the measured data through the collimator slits are to be used in the computation. The number of slits and the reciprocation frequency have been varied and the effects of them on the image quality were investigated. We also analyzed the sampling efficiency: the sampling density and data incoherence in each case. We tested three sets of slits with their number of 6, 12 and 18, each at reciprocation frequencies of 10, 30, 50 and 70 Hz/ro. Results: Consistent results in the image quality have been produced with the sampling efficiency, and the optimum condition was found to be using 12 slits at 30 Hz/ro. As image quality indices, we used the CNR and the detectability. Conclusion: We conducted an experiment with a moving multi-slit collimator to realize a sparse-sampled cone-beam CT. Effects of collimator parameters on the image quality have been systematically investigated, and the optimum condition has been reached.

  19. Preparation and Comparison of the Photoelectronic Properties of Sr2Nb207 and Ba0.5Sr0.5Nb2O6.

    Science.gov (United States)

    1979-08-20

    eV, but a flat-band potential of 0.1 V vs SCE at a pH of 13.3. Hence, the gain of utilizing a larger portion of the solar spectrum obtained from the...as a tetragonally distorted perovskite , ( 3) whereas Sr2Nb2O7 was reported to be orthorhombic (4). - 1...glass cell with a quartz window, and a current amplifier as nreviously described (8). The electrolyte, 0.2 M sodium acetate (pH 8.3), was purged of

  20. Análisis de parámetros influyentes en el diseño de columnas esbeltas según la NC 207:2003.

    OpenAIRE

    Limnavel Pestana Morejón; Carlos Rodríguez García

    2016-01-01

    Las Columnas son elementos sometidos a la acción combinada de momento y carga axial, su principal objetivo es sostener en altura los elementos que conforman los entrepisos y cubiertas. Estas son elementos lineares, donde una de sus dimensiones es muy superior a las restantes, trayendo consigo deformaciones de segundo orden producto al pandeo. Las normativas vigentes, en diferentes regiones, traducen este efecto en una amplificación de las solicitaciones, basados en diferentes métodos, con el ...

  1. TU-CD-207-03: Time Evolution of Texture Parameters of Subtracted Images Obtained by Contrast-Enhanced Digital Mammography (CEDM)

    Energy Technology Data Exchange (ETDEWEB)

    Mateos, M-J; Brandan, M-E [Instituto de Fisica, Universidad Nacional Autonom de Mexico, Mexico, Distrito Federal (Mexico); Gastelum, A; Marquez, J [Centro de Ciencias Aplicadas y Desarrollo Tecnologico Universidad Nacional Autonoma de Mexico, Mexico, Distrito Federal (Mexico)

    2015-06-15

    Purpose: To evaluate the time evolution of texture parameters, based on the gray level co-occurrence matrix (GLCM), in subtracted images of 17 patients (10 malignant and 7 benign) subjected to contrast-enhanced digital mammography (CEDM). The goal is to determine the sensitivity of texture to iodine uptake at the lesion, and its correlation (or lack of) with mean-pixel-value (MPV). Methods: Acquisition of clinical images followed a single-energy CEDM protocol using Rh/Rh/48 kV plus external 0.5 cm Al from a Senographe DS unit. Prior to the iodine-based contrast medium (CM) administration a mask image was acquired; four CM images were obtained 1, 2, 3, and 5 minutes after CM injection. Temporal series were obtained by logarithmic subtraction of registered CM minus mask images.Regions of interest (ROI) for the lesion were drawn by a radiologist and the texture was analyzed. GLCM was evaluated at a 3 pixel distance, 0° angle, and 64 gray-levels. Pixels identified as registration errors were excluded from the computation. 17 texture parameters were chosen, classified according to similarity into 7 groups, and analyzed. Results: In all cases the texture parameters within a group have similar dynamic behavior. Two texture groups (associated to cluster and sum mean) show a strong correlation with MPV; their average correlation coefficient (ACC) is r{sup 2}=0.90. Other two groups (contrast, homogeneity) remain constant with time, that is, a low-sensitivity to CM uptake. Three groups (regularity, lacunarity and diagonal moment) are sensitive to CM uptake but less correlated with MPV; their ACC is r{sup 2}=0.78. Conclusion: This analysis has shown that, at least groups associated to regularity, lacunarity and diagonal moment offer dynamical information additional to the mean pixel value due to the presence of CM at the lesion. The next step will be the analysis in terms of the lesion pathology. Authors thank PAPIIT-IN105813 for support. Consejo Nacional de Ciencia Y Tecnologia, PAPIIT-IN105813.

  2. [207-POS]: Termination of pregnancy for hypertensive disorders prior to fetal viability in the Netherlands: A retrospective cohort study in 10 Dutch tertiary care centers

    NARCIS (Netherlands)

    Eerden, L. van; Zeeman, G.G.; Christiaens, G.C.; Vandenbussche, F.P.; Oei, S.G.; Scheepers, H.C.J.; Eyck, J. van; Middledorp, J.M.; Pajkrt, E.; Duvekot, J.J.; Groot, C.J. de; Bolte, A.C.

    2015-01-01

    OBJECTIVES: To ascertain the incidence and demographic data of TOP for hypertensive disorders at the limits of fetal viability. METHODS: We conducted a retrospective cohort study. All terminations for hypertensive disorders between 2000 and 2009 in the ten Dutch tertiary care centers with a gestatio

  3. CENER/NREL Collaboration in Testing Facility and Code Development: Cooperative Research and Development Final Report, CRADA Number CRD-06-207

    Energy Technology Data Exchange (ETDEWEB)

    Moriarty, P.

    2014-11-01

    Under the funds-in CRADA agreement, NREL and CENER will collaborate in the areas of blade and drivetrain testing facility development and code development. The project shall include NREL assisting in the review and instruction necessary to assist in commissioning the new CENER blade test and drivetrain test facilities. In addition, training will be provided by allowing CENER testing staff to observe testing and operating procedures at the NREL blade test and drivetrain test facilities. CENER and NREL will exchange blade and drivetrain facility and equipment design and performance information. The project shall also include exchanging expertise in code development and data to validate numerous computational codes.

  4. 206/207Pb and Radiocarbon: An Unlikely Pair for Identifying the Source and Delivery Time of Ocean Advection in the South China Sea

    Science.gov (United States)

    Switzer, A.; Goodkin, N.; Bolton, A.; Chen, M.; Druffel, E. R. M.; Boyle, E. A.

    2015-12-01

    Two independent studies were undertaken to use anthropogenic emissions to investigate natural systems using a massive Porites coral taken from off the coast of Vietnam (12ο12'49.90"N, 109 ο18'17.51"E). Annual uptake of bomb radiocarbon (14CO2) was measured to investigate the impact of coastal upwelling; while Pb/Ca levels and Pb isotopes were measured to investigate oceanic infiltration of anthropogenic Pb. Both records reveal a signal of sub-surface seawater advection from the tropical North Pacific to the South China Sea (SCS) providing independent evidence for the source and delivery time of the upwelled water off the coast of Vietnam. The radiocarbon record, extending from 1900-1986 at ~annual resolution, shows a post-bomb peak lower and broader than those found from other corals in the SCS and Japan, but higher than those found in the Makassar Strait in Indonesia. The Makassar coral experiences three water masses: the South Equatorial Current (SEC), upwelled and SCS water. The SEC has a relatively low radiocarbon content. However, water in the SCS does not mix with SEC water that enters the Indonesia Seas via the Halmahera as the main throughflow is from north to south. Hence, the upwelling signature must be from the North Equatorial Current that enters from the Luzon strait at depth. Leaded gasoline was phased-out between 1997 and 2000 in most Asian countries, however unlike other regional records, the Pb/Ca of the coral continued to increase until 2004 indicating a non-atmospheric source of Pb to the region. Both records indicate the source of upwelled water from the tropical North Pacific at roughly ~100-200 meters with a transport time of >2-5 years. This water is carried westward, via the Luzon Strait and into the South China Sea, where is it upwelled during the summer months. A higher resolution study of this coral combined with other coral records from the region could further narrow the location and timing of the advection and upwelling.

  5. The knowledge of pregnant teenagers on Speech Therapy related to maternal-infant health care - doi:10.5020/18061230.2007.p207

    Directory of Open Access Journals (Sweden)

    Daniela Carvalho Neves

    2012-01-01

    Full Text Available This study had as its objective to investigate the knowledge of pregnant teenagers on Speech Therapy related to maternal-infant health care. A qualitative analysis was made based on a thematic investigation of the subject matter. Ten pregnant teenagers with chronological age between ten and nineteen years old joined in the survey. They found themselves around the fifth and ninth months of gestation age, being attended at the Center of Pregnant TeenagersAttention Care at Fortaleza General Hospital. The collection of data involved the application of a semi-structured interview broaching topics that could identify what the pregnant teenagers knew about Speech Therapy and maternal-infant care. Education interventions, related to Speech Therapy health promotion, were also accomplished. The results pointed out that the pregnant teenagers’ level of knowledge on aspects such as: food transition and utensils, oral habits, language stimulation and hearing loss detection, was still incipient and unsatisfactory. It is concluded that the knowledge of the pregnant teenagers on Speech Therapy related to maternal-infant health care was unsatisfactory, which demonstrates the importance of education interventions related to human communication health care for this studied sample.

  6. The knowledge of pregnant teenagers on Speech Therapy related to maternal-infant health care - doi:10.5020/18061230.2007.p207

    OpenAIRE

    Daniela Carvalho Neves; Aline Maria de Araújo Aguiar; Izabella Santos Nogueira de Andrade

    2012-01-01

    This study had as its objective to investigate the knowledge of pregnant teenagers on Speech Therapy related to maternal-infant health care. A qualitative analysis was made based on a thematic investigation of the subject matter. Ten pregnant teenagers with chronological age between ten and nineteen years old joined in the survey. They found themselves around the fifth and ninth months of gestation age, being attended at the Center of Pregnant TeenagersAttention Care at Fortaleza General H...

  7. SU-D-207-06: Clinical Validations of Shading Correction for Cone-Beam CT Using Planning CT as a Prior

    Energy Technology Data Exchange (ETDEWEB)

    Tsui, T; Zhu, L [Georgia Institute of Technology, Atlanta, GA (Georgia); Wei, J [Landauer Medical Physics, Newnan, GA (United States)

    2015-06-15

    Purpose: Current cone-beam CT (CBCT) images contain severe shading artifacts mainly due to scatter, hindering their quantitative use in current radiation therapy. We have previously proposed an effective shading correction method for CBCT using planning CT (pCT) as prior knowledge. In this work, we investigate the method robustness via statistical analyses on studies of a large patient group and compare the performance with that of a state-of-the-art method implemented on the current commercial radiation therapy machine -- the Varian Truebeam system. Methods: Since radiotherapy patients routinely undergo multiple-detector CT (MDCT) scans in the planning procedure, we use the high-quality pCT as “free” prior knowledge for CBCT image improvement. The CBCT image with no correction is first spatially registered with the pCT. Primary CBCT projections are estimated via forward projections of the registered image. The low frequency errors in the projections, which stem from mainly scatter, are estimated by filtering the difference between original line integral and the estimated scatter projections. The corrected CBCT image is then reconstructed from the scatter corrected projections. The proposed method is evaluated on 40 cancer patients. Results: On all patient images, we compare errors on CT number, spatial non-uniformity (SNU) and image contrast, using pCT as the ground truth. T-tests show that our algorithm improves over the Varian method on CBCT accuracies of CT number and SNU with 90% confident. The average CT number error is reduced from 54.8 HU on the Varian method to 40.9 HU, and the SNU error is reduced from 7.7% to 3.8%. There is no obvious improvement on image contrast. Conclusion: Large-group patient studies show that the proposed pCT-based algorithm outperforms the Varian method of the Truebeam system on CBCT shading correction, by providing CBCT images with higher CT number accuracy and greater image uniformity.

  8. 207. Terapia de resincronización cardíaca en la práctica clínica diaria. seguimiento a medio plazo

    Directory of Open Access Journals (Sweden)

    N. Miranda

    2012-04-01

    Conclusiones: La TRC es una terapia eficaz en el tratamiento de los pacientes con insuficiencia cardíaca refractaria al tratamiento convencional en nuestro medio. Es fundamental una correcta selección de los pacientes que van a ser sometidos a dicha terapia con vistas a mejorar la efectividad de ésta.

  9. WE-A-207-00: In Memoriam of Jacques Ovadia - Reinvigorating Scientific Excellence: Electron Beam Therapy - Past, Present and Future

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed.

  10. SU-D-207A-04: Use of Gradient Echo Plural Contrast Imaging (GEPCI) in MR-Guided Radiation Therapy: A Feasibility Study Targeting Brain Treatment

    Energy Technology Data Exchange (ETDEWEB)

    Cai, B; Rao, Y; Tsien, C; Huang, J; Green, O; Mutic, S; Gach, H [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States); Wen, J; Yablonskiy, D [Department of Radiology, Washington University School of Medicine, St Louis, MO (United States)

    2016-06-15

    Purpose: To implement the Gradient Echo Plural Contrast Imaging(GEPCI) technique in MRI-simulation for radiation therapy and assess the feasibility of using GEPCI images with advanced inhomogeneity correction in MRI-guided radiotherapy for brain treatment. Methods: An optimized multigradient-echo GRE sequence (TR=50ms;TE1=4ms;delta-TE=4ms;flip angle=300,11 Echoes) was developed to generate both structural (T1w and T2*w) and functional MRIs (field and susceptibility maps) from a single acquisition. One healthy subject (Subject1) and one post-surgical brain cancer patient (Subject2) were scanned on a Philips Ingenia 1.5T MRI used for radiation therapy simulation. Another healthy subject (Subject3) was scanned on a 0.35T MRI-guided radiotherapy (MR-IGRT) system (ViewRay). A voxel spread function (VSF) was used to correct the B0 inhomogeneities caused by surgical cavities and edema for Subject2. GEPCI images and standard radiotherapy planning MRIs for this patient were compared focusing the delineation of radiotherapy target region. Results: GEPCI brain images were successfully derived from all three subjects with scan times of <7 minutes. The images derived for Subjects1&2 demonstrated that GEPCI can be applied and combined into radiotherapy MRI simulation. Despite low field, T1-weighted and R2* images were successfully reconstructed for Subject3 and were satisfactory for contour and target delineation. The R2* distribution of grey matter (center=12,FWHM=4.5) and white matter (center=14.6, FWHM=2) demonstrated the feasibility for tissue segmentation and quantification. The voxel spread function(VSF) corrected surgical site related inhomogeneities for Subject2. R2* and quantitative susceptibility map(QSM) images for Subject2 can be used to quantitatively assess the brain structure response to radiation over the treatment course. Conclusion: We implemented the GEPCI technique in MRI-simulation and in MR-IGRT system for radiation therapy. The images demonstrated that it is feasible to adopt this technique in radiotherapy for structural delineation. The preliminary data also enable the opportunity for quantitative assessment of radiation response of the target region and normal tissue.

  11. TU-CD-207-09: Analysis of the 3-D Shape of Patients’ Breast for Breast Imaging and Surgery Planning

    Energy Technology Data Exchange (ETDEWEB)

    Agasthya, G; Sechopoulos, I [Emory University, Atlanta, GA (United States)

    2015-06-15

    Purpose: Develop a method to accurately capture the 3-D shape of patients’ external breast surface before and during breast compression for mammography/tomosynthesis. Methods: During this IRB-approved, HIPAA-compliant study, 50 women were recruited to undergo 3-D breast surface imaging during breast compression and imaging for the cranio-caudal (CC) view on a digital mammography/breast tomosynthesis system. Digital projectors and cameras mounted on tripods were used to acquire 3-D surface images of the breast, in three conditions: (a) positioned on the support paddle before compression, (b) during compression by the compression paddle and (c) the anterior-posterior view with the breast in its natural, unsupported position. The breast was compressed to standard full compression with the compression paddle and a tomosynthesis image was acquired simultaneously with the 3-D surface. The 3-D surface curvature and deformation with respect to the uncompressed surface was analyzed using contours. The 3-D surfaces were voxelized to capture breast shape in a format that can be manipulated for further analysis. Results: A protocol was developed to accurately capture the 3-D shape of patients’ breast before and during compression for mammography. Using a pair of 3-D scanners, the 50 patient breasts were scanned in three conditions, resulting in accurate representations of the breast surfaces. The surfaces were post processed, analyzed using contours and voxelized, with 1 mm{sup 3} voxels, converting the breast shape into a format that can be easily modified as required. Conclusion: Accurate characterization of the breast curvature and shape for the generation of 3-D models is possible. These models can be used for various applications such as improving breast dosimetry, accurate scatter estimation, conducting virtual clinical trials and validating compression algorithms. Ioannis Sechopoulos is consultant for Fuji Medical Systems USA.

  12. TU-CD-207-12: Impact of Anatomical Noise On Detection Performance of Microcalcifications in Multi-Contrast Breast Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, J; Ge, Y; Li, K; Chen, G [University of Wisconsin, Madison, WI (United States)

    2015-06-15

    Purpose: The anatomical noise power spectra (NPS) for differential phase contrast (DPC) and dark field (DF) imaging have recently been characterized using a power-law model with two parameters, alpha and beta, an innovative extension to the methodology used in x-ray attenuation based breast imaging such as mammography, DBT, or cone-beam CT. Beta values of 3.6, 2.6, and 1.3 have been measured for absorption, DPC, and DF respectively for cadaver breasts imaged in the coronal plane; these dramatic differences should be reflected in their detection performance. The purpose of this study was to determine the impact of anatomical noise on breast calcification detection and compare the detection performance of the three contrast mechanisms of a multi-contrast x-ray imaging system. Methods: In our studies, a calcification image object was segmented out of the multi-contrast images of a cadaver breast specimen. 50 measured total NPS were measured from breast cadavers directly. The ideal model observer detectability was calculated for a range of doses (5–100%) and a range of calcification sizes (diameter = 0.25–2.5 mm). Results: Overall we found the highest average detectability corresponded to DPC imaging (7.4 for 1 mm calc.), with DF the next highest (3.8 for 1 mm calc.), and absorption the lowest (3.2 for 1 mm calc.). However, absorption imaging also showed the slowest dependence on dose of the three modalities due to the significant anatomical noise. DPC showed a peak detectability for calcifications ∼1.25 mm in diameter, DF showed a peak for calcifications around 0.75 mm in diameter, and absorption imaging had no such peak in the range explored. Conclusion: Understanding imaging performance for DPC and DF is critical to transition these modalities to the clinic. The results presented here offer new insight into how these modalities complement absorption imaging to maximize the likelihood of detecting early breast cancers. J. Garrett, Y. Ge, K. Li: Nothing to disclose. G.-H. Chen: Research funded, GE Healthcare; Research funded, Siemens AX.

  13. Reprint of "The role of cytoskeleton in the regulation of vascular endothelial barrier function" [Microvascular Research 76 (2008) 202-207].

    Science.gov (United States)

    Bogatcheva, Natalia V; Verin, Alexander D

    2009-01-01

    The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential.

  14. 33 CFR 207.249 - Ouachita and Black Rivers, Ark. and La., Mile 0.0 to Mile 338.0 (Camden, Ark.) above the mouth of...

    Science.gov (United States)

    2010-07-01

    ... other lockages, then separate lockages shall be made. Dangerous cargoes are described in 46 CFR part 146... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Ouachita and Black Rivers, Ark. and La., Mile 0.0 to Mile 338.0 (Camden, Ark.) above the mouth of the Black River; the Red River,...

  15. The Beaverdam Group: Archaeological Investigations at 9EB92, 9EB207, 9EB208 and 9EB219 Richard B. Russell Multiple Resource Area, Elbert County, Georgia.

    Science.gov (United States)

    1984-01-01

    36 Laboratory Methods ........... .................. ..... .. 37 -- Lithic Analysis ................................... 37...historic activity. The majority of the historic items were expended shotgun shells and discarded cans. Lithic Analysis The majority of artifacts...recovered from the Beaverdam Group sites consists of lithic material, most of which is crudely worked. Lithic analysis proceeded on the basis of two

  16. WE-EF-207-04: An Inter-Projection Sensor Fusion (IPSF) Approach to Estimate Missing Projection Signal in Synchronized Moving Grid (SMOG) System

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, H; Kong, V; Jin, J [Georgia Regents University Cancer Center, Augusta, GA (Georgia); Ren, L; Zhang, Y; Giles, W [Duke University Medical Center, Durham, NC (United States)

    2015-06-15

    Purpose: A synchronized moving grid (SMOG) has been proposed to reduce scatter and lag artifacts in cone beam computed tomography (CBCT). However, information is missing in each projection because certain areas are blocked by the grid. A previous solution to this issue is acquiring 2 complimentary projections at each position, which increases scanning time. This study reports our first Result using an inter-projection sensor fusion (IPSF) method to estimate missing projection in our prototype SMOG-based CBCT system. Methods: An in-house SMOG assembling with a 1:1 grid of 3 mm gap has been installed in a CBCT benchtop. The grid moves back and forth in a 3-mm amplitude and up-to 20-Hz frequency. A control program in LabView synchronizes the grid motion with the platform rotation and x-ray firing so that the grid patterns for any two neighboring projections are complimentary. A Catphan was scanned with 360 projections. After scatter correction, the IPSF algorithm was applied to estimate missing signal for each projection using the information from the 2 neighboring projections. Feldkamp-Davis-Kress (FDK) algorithm was applied to reconstruct CBCT images. The CBCTs were compared to those reconstructed using normal projections without applying the SMOG system. Results: The SMOG-IPSF method may reduce image dose by half due to the blocked radiation by the grid. The method almost completely removed scatter related artifacts, such as the cupping artifacts. The evaluation of line pair patterns in the CatPhan suggested that the spatial resolution degradation was minimal. Conclusion: The SMOG-IPSF is promising in reducing scatter artifacts and improving image quality while reducing radiation dose.

  17. WE-EF-207-08: Improve Cone Beam CT Using a Synchronized Moving Grid, An Inter-Projection Sensor Fusion and a Probability Total Variation Reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, H; Kong, V; Jin, J [Georgia Regents University Cancer Center, Augusta, GA (Georgia); Ren, L; Zhang, Y; Giles, W [Duke University Medical Center, Durham, NC (United States)

    2015-06-15

    Purpose: To present a cone beam computed tomography (CBCT) system, which uses a synchronized moving grid (SMOG) to reduce and correct scatter, an inter-projection sensor fusion (IPSF) algorithm to estimate the missing information blocked by the grid, and a probability total variation (pTV) algorithm to reconstruct the CBCT image. Methods: A prototype SMOG-equipped CBCT system was developed, and was used to acquire gridded projections with complimentary grid patterns in two neighboring projections. Scatter was reduced by the grid, and the remaining scatter was corrected by measuring it under the grid. An IPSF algorithm was used to estimate the missing information in a projection from data in its 2 neighboring projections. Feldkamp-Davis-Kress (FDK) algorithm was used to reconstruct the initial CBCT image using projections after IPSF processing for pTV. A probability map was generated depending on the confidence of estimation in IPSF for the regions of missing data and penumbra. pTV was finally used to reconstruct the CBCT image for a Catphan, and was compared to conventional CBCT image without using SMOG, images without using IPSF (SMOG + FDK and SMOG + mask-TV), and image without using pTV (SMOG + IPSF + FDK). Results: The conventional CBCT without using SMOG shows apparent scatter-induced cup artifacts. The approaches with SMOG but without IPSF show severe (SMOG + FDK) or additional (SMOG + TV) artifacts, possibly due to using projections of missing data. The 2 approaches with SMOG + IPSF removes the cup artifacts, and the pTV approach is superior than the FDK by substantially reducing the noise. Using the SMOG also reduces half of the imaging dose. Conclusion: The proposed technique is promising in improving CBCT image quality while reducing imaging dose.

  18. SU-F-207-02: Use of Postmortem Subjects for Subjective Image Quality Assessment in Abdominal CT Protocols with Iterative Reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Mench, A [Salem Hospital, Salem, OR (United States); Lipnharski, I; Carranza, C; Lamoureux, R; Smajdor, L; Cormack, B; Mohammed, T; Rill, L; Arreola, M [University of Florida, Gainesville, FL (United States); Sinclair, L [Oregon Health & Science University, Portland, OR (United States)

    2015-06-15

    Purpose: New radiation dose reduction technologies are emerging constantly in the medical imaging field. The latest of these technologies, iterative reconstruction (IR) in CT, presents the ability to reduce dose significantly and hence provides great opportunity for CT protocol optimization. However, without effective analysis of image quality, the reduction in radiation exposure becomes irrelevant. This work explores the use of postmortem subjects as an image quality assessment medium for protocol optimizations in abdominal CT. Methods: Three female postmortem subjects were scanned using the Abdomen-Pelvis (AP) protocol at reduced minimum tube current and target noise index (SD) settings of 12.5, 17.5, 20.0, and 25.0. Images were reconstructed using two strengths of iterative reconstruction. Radiologists and radiology residents from several subspecialties were asked to evaluate 8 AP image sets including the current facility default scan protocol and 7 scans with the parameters varied as listed above. Images were viewed in the soft tissue window and scored on a 3-point scale as acceptable, borderline acceptable, and unacceptable for diagnosis. The facility default AP scan was identified to the reviewer while the 7 remaining AP scans were randomized and de-identified of acquisition and reconstruction details. The observers were also asked to comment on the subjective image quality criteria they used for scoring images. This included visibility of specific anatomical structures and tissue textures. Results: Radiologists scored images as acceptable or borderline acceptable for target noise index settings of up to 20. Due to the postmortem subjects’ close representation of living human anatomy, readers were able to evaluate images as they would those of actual patients. Conclusion: Postmortem subjects have already been proven useful for direct CT organ dose measurements. This work illustrates the validity of their use for the crucial evaluation of image quality during CT protocol optimization, especially when investigating the effects of new technologies.

  19. UGT2B17 genotype and the pharmacokinetic serum profile of testosterone during substitution therapy with testosterone undecanoate. A retrospective experience from 207 men with hypogonadism

    DEFF Research Database (Denmark)

    Bang, Anne Kirstine; Jørgensen, Niels; Rajpert-De Meyts, Ewa

    2013-01-01

    Background: Testosterone (T) is mainly excreted in the urine as testosterone glucuronide (TG). This glucuronidation is partly dependent on the UGT2B17 genotype, and TG excretion is therefore lower in men having the UGT2B17 deletion. However, the possible influence of UGT2B17 genotype on serum T...... during androgen therapy is unknown. We retrospectively investigated the possible association between the UGT2B17 gene polymorphism and serum T levels in hypogonadal men during Testosterone undecanoate (TU) substitution therapy. Subjects and Methods: Two hundred and seven patients treated with TU (Nebido......(®)) were genotyped by quantitative polymerase chain reaction for the UGT2B17 deletion polymorphism. All were given 1000 mg TU per injection at 0, 6, and 18 weeks. Blood samples were taken 2 and 6 weeks after the first and second injection, prior to the third injection, and after 2-3 years of treatment. We...

  20. Non-Destructive Assessment of Concrete Structures Reliability and Limits of Single and Combined Techniques State-of-the-Art Report of the RILEM Technical Committee 207-INR

    CERN Document Server

    2012-01-01

    This book gives information on non destructive techniques for assessment of concrete structures. It synthesizes the best of international knowledge about what techniques can be used for assessing material properties (strength) and structural properties (geometry, defects...). It describes how the techniques can be used so as to answer a series of usual questions, highlighting their capabilities and limits, and providing advices for a better use of techniques. It also focuses on possible combinations of techniques so as to improve the assessment. It is based on many illustrative examples and give in each case references to standards and guidelines.

  1. Semente residual do urucum na alimentação de poedeiras comerciais: desempenho e características dos ovos - DOI: 10.4025/actascianimsci.v29i2.207 Annato seed byproduct used as a source of pigment in laying hen diets - DOI: 10.4025/actascianimsci.v29i2.207

    Directory of Open Access Journals (Sweden)

    Rafaele Ferreira Moreira

    2007-11-01

    Full Text Available O experimento foi conduzido para avaliar o efeito da inclusão da semente residual de urucum (SRU sobre o desempenho e qualidade dos ovos de poedeiras comerciais alimentadas com rações contendo sorgo. Cento e quarenta e quatro poedeiras comerciais foram distribuídas em um delineamento inteiramente ao acaso com seis tratamentos e seis repetições de quatro aves. Os tratamentos consistiram em uma ração � base de milho e, as demais, � base de sorgo com a inclusão de 0,0; 0,5; 1,0;1,5 e 2,0% de SRU. As variáveis: consumo de ração, percentagem de postura, peso e massa de ovo, conversão alimentar, percentagem de gema, albúmem e casca e unidades Haugh não foram afetadas significativamente pelos níveis de inclusão de SRU. Entretanto, a pigmentação da gema aumentou linearmente com o aumento de SRU na ração. A inclusão de 2% de SRU em rações contendo sorgo foi capaz de pigmentar as gemas em, aproximadamente, 61,4% da pigmentação obtida em rações compostas por milho.This experiment was conducted to evaluate the effect of inclusion of annatto (Bixa orellana L. seed byproduct (ASB in diets with sorghum on laying hens performance and eggs characteristics. A hundred and forty-four laying hens were randomly allotted to six treatments and six replications with four birds each. Treatments consisted of one diet based on corn and the five others based on sorghum with the inclusion of 0.0; 0.5; 1.0; 1.5 and 2.0% of ASB. Feed intake, egg production, egg weight, egg mass, feed conversion, yolk, albumen and shell percentages and Haugh units were not affected by the inclusion levels of ASB. However, yolk colour increased linearly as ASB increased in diet. The inclusion of 2% of annatto seed byproduct on laying hens diets based on sorghum improves egg yolk colour nearly 61.4% of that obtained with birds fed diet based on yellow corn.

  2. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  3. Behaviour of uranium series radionuclides in surface water (Crouzille, Limousin). Geochemical implications; Comportement des radionucleides des familles de l'uranium dans les eaux superficielles du site de la Crouzille (Limousin): implications geochimiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-06-15

    Understanding natural radionuclides behaviour in surface water is a required step to achieve uranium mine rehabilitation and preserve water quality. The first objective of this thesis is to determine which are the radionuclides sources in a drinking water reservoir. The second objective is to improve the knowledge about the behaviour of uranium series radionuclides, especially actinium. The investigated site is a brook (Sagnes, Limousin, France) which floods a peat bog contaminated by a former uranium mine and which empties into the Crouzille lake. It allows studying radionuclides transport in surface water and radionuclides retention through organic substance or water reservoir. Radionuclides distribution in particulate, colloidal and dissolved phases is determined thanks to ultra-filtrations. Gamma spectrometry allows measuring almost all natural radionuclides with only two counting stages. However, low activities of {sup 235}U series radionuclides impose the use of very low background well-type Ge detectors, such as those of the Underground Laboratory of Modane (France). Firstly, this study shows that no or few radionuclides are released by the Sagnes peat bog, although its radioactivity is important. Secondly, it provides details on the behaviour of uranium series radionuclides in surface water. More specifically, it provides the first indications of actinium solubility in surface water. Actinium's behaviour is very close to uranium's even if it is a little less soluble. (author)

  4. The Distinct Behavior of Sedimentary Target Rocks During the Chicxulub Impact Event: Observations at Proximal and Distal Ejecta Deposits at K-Pg Sites El Guayal, La Lajilla, and Drill Cores UNAM-7 and ODP 207

    Science.gov (United States)

    Salge, T.; Goran, D.; Schulte, P.; Deutsch, A.

    2013-08-01

    EDS/EBSD analysis indicate melting and dissociation of carbonates and sulfates. Reformation of calcite would cause a prolongued release of thermal energy that may have initiated a delayed vapor release. It could force the gas driven ejecta transport.

  5. Multibeam collection for KN207-01: Multibeam data collected aboard Knorr from 2012-04-21 to 2012-05-04, departing from Woods Hole, MA and returning to St. George's, Bermuda

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  6. Multibeam collection for KN207-02: Multibeam data collected aboard Knorr from 2012-05-09 to 2012-06-11, departing from St. George's, Bermuda and returning to Ponta Delgada, Azores

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  7. SU-D-207A-07: The Effects of Inter-Cycle Respiratory Motion Variation On Dose Accumulation in Single Fraction MR-Guided SBRT Treatment of Renal Cell Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Stemkens, B; Glitzner, M; Kontaxis, C; Prins, F; Crijns, SPM; Kerkmeijer, L; Lagendijk, J; Berg, CAT van den; Tijssen, RHN [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands); Denis de Senneville, B [Imaging Division, University Medical Center Utrecht, Utrecht (Netherlands); IMB, UMR 5251 CNRS/University of Bordeaux (France)

    2016-06-15

    Purpose: To assess the dose deposition in simulated single-fraction MR-Linac treatments of renal cell carcinoma, when inter-cycle respiratory motion variation is taken into account using online MRI. Methods: Three motion characterization methods, with increasing complexity, were compared to evaluate the effect of inter-cycle motion variation and drifts on the accumulated dose for an SBRT kidney MR-Linac treatment: 1) STATIC, in which static anatomy was assumed, 2) AVG-RESP, in which 4D-MRI phase-volumes were time-weighted, based on the respiratory phase and 3) PCA, in which 3D volumes were generated using a PCA-model, enabling the detection of inter-cycle variations and drifts. An experimental ITV-based kidney treatment was simulated in a 1.5T magnetic field on three volunteer datasets. For each volunteer a retrospectively sorted 4D-MRI (ten respiratory phases) and fast 2D cine-MR images (temporal resolution = 476ms) were acquired to simulate MR-imaging during radiation. For each method, the high spatio-temporal resolution 3D volumes were non-rigidly registered to obtain deformation vector fields (DVFs). Using the DVFs, pseudo-CTs (generated from the 4D-MRI) were deformed and the dose was accumulated for the entire treatment. The accuracies of all methods were independently determined using an additional, orthogonal 2D-MRI slice. Results: Motion was most accurately estimated using the PCA method, which correctly estimated drifts and inter-cycle variations (RMSE=3.2, 2.2, 1.1mm on average for STATIC, AVG-RESP and PCA, compared to the 2DMRI slice). Dose-volume parameters on the ITV showed moderate changes (D99=35.2, 32.5, 33.8Gy for STATIC, AVG-RESP and PCA). AVG-RESP showed distinct hot/cold spots outside the ITV margin, which were more distributed for the PCA scenario, since inter-cycle variations were not modeled by the AVG-RESP method. Conclusion: Dose differences were observed when inter-cycle variations were taken into account. The increased inter-cycle randomness in motion as captured by the PCA model mitigates the local (erroneous) hotspots estimated by the AVG-RESP method.

  8. WE-G-207-06: 3D Fluoroscopic Image Generation From Patient-Specific 4DCBCT-Based Motion Models Derived From Physical Phantom and Clinical Patient Images

    Energy Technology Data Exchange (ETDEWEB)

    Dhou, S; Cai, W; Hurwitz, M; Rottmann, J; Myronakis, M; Cifter, F; Berbeco, R; Lewis, J [Brigham and Women’s Hospital, Boston, MA (United States); Williams, C [Harvard Medical School, Cambridge, MA (United States); Mishra, P [Varian Medical Systems, Palo Alto, CA (United States); Ionascu, D [William Beaumont Hospital, Royal Oak, MI (United States)

    2015-06-15

    Purpose: Respiratory-correlated cone-beam CT (4DCBCT) images acquired immediately prior to treatment have the potential to represent patient motion patterns and anatomy during treatment, including both intra- and inter-fractional changes. We develop a method to generate patient-specific motion models based on 4DCBCT images acquired with existing clinical equipment and used to generate time varying volumetric images (3D fluoroscopic images) representing motion during treatment delivery. Methods: Motion models are derived by deformably registering each 4DCBCT phase to a reference phase, and performing principal component analysis (PCA) on the resulting displacement vector fields. 3D fluoroscopic images are estimated by optimizing the resulting PCA coefficients iteratively through comparison of the cone-beam projections simulating kV treatment imaging and digitally reconstructed radiographs generated from the motion model. Patient and physical phantom datasets are used to evaluate the method in terms of tumor localization error compared to manually defined ground truth positions. Results: 4DCBCT-based motion models were derived and used to generate 3D fluoroscopic images at treatment time. For the patient datasets, the average tumor localization error and the 95th percentile were 1.57 and 3.13 respectively in subsets of four patient datasets. For the physical phantom datasets, the average tumor localization error and the 95th percentile were 1.14 and 2.78 respectively in two datasets. 4DCBCT motion models are shown to perform well in the context of generating 3D fluoroscopic images due to their ability to reproduce anatomical changes at treatment time. Conclusion: This study showed the feasibility of deriving 4DCBCT-based motion models and using them to generate 3D fluoroscopic images at treatment time in real clinical settings. 4DCBCT-based motion models were found to account for the 3D non-rigid motion of the patient anatomy during treatment and have the potential to localize tumor and other patient anatomical structures at treatment time even when inter-fractional changes occur. This project was supported, in part, through a Master Research Agreement with Varian Medical Systems, Inc., Palo Alto, CA. The project was also supported, in part, by Award Number R21CA156068 from the National Cancer Institute.

  9. WE-G-207-03: Mask Guided Image Reconstruction (MGIR): A Novel Method for Ultra-Low-Dose 3D and Enhanced 4D Cone-Beam Computer-Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Park, C; Zhang, H; Chen, Y; Fan, Q; Kahler, D; Li, J; Liu, C; Lu, B [Univ Florida, Gainesville, FL (United States)

    2015-06-15

    Purpose: Recently, compressed sensing (CS) based iterative reconstruction (IR) method is receiving attentions to reconstruct high quality cone beam computed tomography (CBCT) images using sparsely sampled or noisy projections. The aim of this study is to develop a novel baseline algorithm called Mask Guided Image Reconstruction (MGIR), which can provide superior image quality for both low-dose 3DCBCT and 4DCBCT under single mathematical framework. Methods: In MGIR, the unknown CBCT volume was mathematically modeled as a combination of two regions where anatomical structures are 1) within the priori-defined mask and 2) outside the mask. Then we update each part of images alternatively thorough solving minimization problems based on CS type IR. For low-dose 3DCBCT, the former region is defined as the anatomically complex region where it is focused to preserve edge information while latter region is defined as contrast uniform, and hence aggressively updated to remove noise/artifact. In 4DCBCT, the regions are separated as the common static part and moving part. Then, static volume and moving volumes were updated with global and phase sorted projection respectively, to optimize the image quality of both moving and static part simultaneously. Results: Examination of MGIR algorithm showed that high quality of both low-dose 3DCBCT and 4DCBCT images can be reconstructed without compromising the image resolution and imaging dose or scanning time respectively. For low-dose 3DCBCT, a clinical viable and high resolution head-and-neck image can be obtained while cutting the dose by 83%. In 4DCBCT, excellent quality 4DCBCT images could be reconstructed while requiring no more projection data and imaging dose than a typical clinical 3DCBCT scan. Conclusion: The results shown that the image quality of MGIR was superior compared to other published CS based IR algorithms for both 4DCBCT and low-dose 3DCBCT. This makes our MGIR algorithm potentially useful in various on-line clinical applications. Provisional Patent: UF#15476; WGS Ref. No. U1198.70067US00.

  10. EVALUACIÓN DE LA MATERIA ORGÁNICA EN EL RÍO FRÍO SOPORTADA EN EL QUAL2K Versión 2.07

    Directory of Open Access Journals (Sweden)

    JORGE VIRGILIO RIVERA GUTIRREZ

    2011-01-01

    Full Text Available El presente artículo estudia el comportamiento de la materia orgánica como carga contaminante en la zona más impactada del río Frío ubicada al sur occidente del Departamento de Santander. El modelamiento condiciona una calibración para minimizar el error paramétrico de las variables que soportan la degradación de la carga orgánica. La información del sistema hidrogeométrico, oxígeno disuelto, carbono, nitrógeno, patógenos y variables meteorológicas son necesarias para el modelamiento. El error paramétrico es calculado aplicando el algoritmo de Monte Carlo y la probabilidad de incertidumbre generalizada, GLUE, sigla inglesa que signifi ca (Generalized Likelihood Uncertainty Estimation. Los parámetros o tasas cinéticas presentan un coefi ciente de determinación (R2 promedio de 0.88 y las variables 0.92. El estudio de la simulación muestra como 61.9 ton.d-1 de carga orgánica vertidas por 38,3000 habitantes de Floridablanca y Bucaramanga, acumulan en el río 16.85 ton.d-1 generando cambios en el balance del oxígeno disuelto como resultado del aumento del carbono y nitrógeno orgánico.

  11. Precambrian crustal evolution and Cretaceous–Palaeogene faulting in West Greenland: 207Pb-206Pb dating of magnetite, monazite and allanite in the central and northern Nagssugtoqidian orogen, West Greenland

    Directory of Open Access Journals (Sweden)

    Frei, Robert

    2006-12-01

    Full Text Available Pb-isotopic data for magnetite from amphibolites in the Nagssugtoqidian orogen, central West Greenland, have been used to trace their source characteristics and the timing of metamorphism. Analyses of the magnetite define a Pb-Pb isochron age of 1726 ± 7 Ma. The magnetite is metamorphic in origin, and the 1726 Ma age is interpreted as a cooling age through the closing temperature of magnetite at ~600°C. Some of the amphibolites in this study come from the Naternaq supracrustal rocks in the northern Nagssugtoqidian orogen, which host the Naternaq sulphide deposit and may be part ofthe Nordre Strømfjord supracrustal suite, which was deposited at around 1950 Ma ago.Pb-isotopic signatures of magnetite from the Arfersiorfik quartz diorite in the central Nagssugtoqidian orogen are compatible with published whole-rock Pb-isotopic data from this suite; previous work has shown that it is a product of subduction-related calc-alkaline magmatism between 1920 and 1870 Ma. Intrusion of pegmatites occurred at around 1800 Ma in both the central and the northernparts of the orogen. Pegmatite ages have been determined by Pb stepwise leaching analyses of allanite and monazite, and source characteristics of Pb point to an origin of the pegmatites by melting of the surrounding late Archaean and Palaeoproterozoic country rocks. Hydrothermal activity took place after pegmatite emplacement and continued below the closure temperature of magnetite at 1800–1650 Ma. Because of the relatively inert and refractory nature of magnetite, Pb-isotopic measurements from this mineral may be of help to understand the metamorphic evolution of geologicallycomplex terrains.

  12. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    P. Bernot

    2005-07-13

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with {sup 231}Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or

  13. Transition wavelengths and unresolved transition array statistics of ions with Z = 72-89

    Energy Technology Data Exchange (ETDEWEB)

    Kilbane, D, E-mail: Deirdre.Kilbane@ucd.ie [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland)

    2011-08-28

    Potential extreme ultraviolet and soft x-ray radiation sources have been identified, using the flexible atomic code (FAC), as emission peaks arising from the 4d-4f and 4p-4d transitions in Pd-like to Rb-like ions of hafnium through actinium. The effects of configuration interaction are investigated and for increasing nuclear charge, these strong emitters are seen to separate and move to shorter wavelengths. Each source is characterized using the unresolved transition array model. They are proposed to complement the currently used nitrogen and argon sources in the 'water window', and as possible successors to tin in next-generation lithography.

  14. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  15. Analysis of the Yrast Bands with q-Deformed Moment of Inertia

    Institute of Scientific and Technical Information of China (English)

    FANG Xiang-Zheng; RUAN Tu-Nan

    2001-01-01

    The rigid-rotor with a q-deformed moment of inertia is introduced to describe the nuclear rotational spectra. With the representations of quantum algebra, the normal deformed and superdeformed bands are naturally differentiated by softness. The yrast normal deformed bands in rare earth and actinium regions, as well as the yrast superdeformed bands in A-190 and 150 regions are investigated. The calculated results agree with experimental data qualitatively well, and the values of the parameters are physically reasonable. This indicates that the fixed deformation, the stretching effect and the many body statistics effect are three possible dominant factors to govern nuclear rotational bands.

  16. Protein (Viridiplantae): 405344 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available 3 ... 424551:133 ... 424574:133 ... 4107:133 49274:207 4081:207 ... PREDICTED: sister chromatid cohesion protein PDS5-like Solanum lycopersicum MEALVADGLLRHCDMDLKVSVASCISEIMRITAPDQPYKDSILKC

  17. Purification of cerium, neodymium and gadolinium for low background experiments

    Directory of Open Access Journals (Sweden)

    Boiko R.S.

    2014-01-01

    Full Text Available Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search, 136Ce (2β+ candidate with one of the highest Q2β. The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  18. Large scale accelerator production of (225)Ac: Effective cross sections for 78-192MeV protons incident on (232)Th targets.

    Science.gov (United States)

    Griswold, J R; Medvedev, D G; Engle, J W; Copping, R; Fitzsimmons, J M; Radchenko, V; Cooley, J C; Fassbender, M E; Denton, D L; Murphy, K E; Owens, A C; Birnbaum, E R; John, K D; Nortier, F M; Stracener, D W; Heilbronn, L H; Mausner, L F; Mirzadeh, S

    2016-12-01

    Actinium-225 and (213)Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of (225)Ac. The high-energy proton spallation reaction on natural thorium metal targets has been utilized to produce millicurie quantities of (225)Ac. The results of sixteen irradiation experiments of thorium metal at beam energies between 78 and 192MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL). Excitation functions for actinium and thorium isotopes, as well as for some of the fission products, are presented. The cross sections for production of (225)Ac range from 3.6 to 16.7mb in the incident proton energy range of 78-192MeV. Based on these data, production of curie quantities of (225)Ac is possible by irradiating a 5.0gcm(-2 232)Th target for 10 days in either BNL or LANL proton irradiation facilities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Directory of Open Access Journals (Sweden)

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  20. Scholars in International Relations Cite Books More Frequently than Journals: More Research is Needed to Better Understand Research Behaviour and Use. A Review of: Zhang, Li. ʺCitation Analysis for Collection Development: A Study of International Relations Journal Literature.ʺ Library Collections, Acquisitions, and Technical Services 31.3‐4 (2007: 195‐207.

    Directory of Open Access Journals (Sweden)

    Megan von Isenburg

    2009-09-01

    Full Text Available Objective – To determine primary type, format, language and subject category of research materials used by U.S. scholars of international relations. Also, to investigate whether research method, qualitative or quantitative, can be correlated with the type and age of sources that scholars use.Design – Citation analysis.Setting – Research articles published in three journals on international relations with high impact factors: International Organization, International Studies Quarterly, and World Politics.Subjects – A random sample of cited references taken from the 410 full‐length research articles published in these journals from 2000 to 2005. Cited references of articles written by authors of foreign institutions (i.e., non‐American institutions, as well as cited references of editorial and research notes, comments, responses, and review essays were excluded.Methods – Cited references were exported from ISI’s Social Science Citation Index (SSCI to MS Excel spreadsheets for analysis. Data was verified against original reference lists. Citations were numbered and identified by source format, place of publication (foreign or domestic, age, and language used, if other than English. The author used a random number generator to select a random sample of 651 from a total of 29,862 citations. Citations were randomly drawn from each journal according to the proportion of the journals’ citations to the total. These citations were analyzed by material type and language. The author also used the Library of Congress Classification Outline to identify the subject category of each book and journal citation in the sample. A separate sampling method was used to investigate if there is a relationship between research methodology and citation behaviour. Each of the original 410 articles was categorized according to research method: quantitative, qualitative or a combination of the two. Two articles representing qualitative research and two representing quantitative research were randomly selected from each of the three journals for each of the six years. Subsequently, five citations from each of the resulting pool of 72 articles were randomly selected to create a sample of 360 citations. These citations were analyzed by material type and age of source.Main Results – Analysis of the citation data showed that books (including monographs, edited books, book chapters and dictionaries made up 48.2% of the total citations; journals (including scholarly and non‐scholarly titles made up 38.4% of the citations; and government publications made up 4.5% of the citations. Electronic resources, which primarily refer to Web sites and digital collections in this study, represented 1.7% of the citations. Other sources of citations included magazines (1.1%, newspapers (1.1%, working papers (1.1%, theses (0.9%, conference papers not yet published as articles (0.6%, and a miscellaneous category, which included items such as committee minutes, radio broadcasts, unpublished materials and personal communications (2.5%. The average age of book citations was 14.3 years and the median age was 8 years. Foreign language citations represented 3.7% of the 651 total citations. The top ranked foreign languages were German (7, French (5, Russian (4, Spanish (3, Korean (2 and Swedish (number not given. Subject analysis of the citations revealed that 38% of all citations were from international relations and two related disciplines, political science, political theory, and public administration. Subject areas outside international relations included social sciences (23.4% ‐ including economics, commerce, industries and finance, history (16.3%, sociology (6.2%, and law (5.9%. Citations from philosophy, psychology, military science and general works together made up 7.3% of the total citations. Citations from science, linguistics, literature, geography and medicine made up less than 2% of the total.Authors of qualitative research articles were more likely to cite books (56.7% than journals (29.4% while authors of quantitative research articles were more likely to cite journals (58.3% than books (28.9%. Authors of qualitative research articles were also more likely to cite government publications and electronic resources than those of quantitative articles. However, authors of quantitative research articles were more likely to cite other materials, such as dissertations, conference papers, working papers and unpublished materials.The age of cited materials for both qualitative and quantitative research articles is similar. Citations to recent materials up to 5 years old were most frequent, followed by materials 6 to 10 years old, materials 11 to 15 years old, and those 26 or more years old. The least frequently cited materials were 16 to 20 and 21 to 25 years old.Conclusion – Scholars in international relations primarily cite books, followed by journals and government publications. Citations to electronic resources such as Web sites and digital collections, and to other materials are far less common. Scholars primarily cite English‐language materials on international relations and related subjects. Authors of qualitative research articles are more likely to cite books than journals, while authors of quantitative research articles are more likely to cite journals than books. Recent materials are more frequently cited than older materials, though materials that are more than 26 years old are still being cited regularly.

  1. Tradutor e intérprete de língua de sinais: história, experiências e caminhos de formaçãoDOI: 10.5007/2175-7968.2010v2n26p207

    Directory of Open Access Journals (Sweden)

    Gisele Iandra Pessini Anater

    2010-10-01

    Full Text Available The aim of this article is to present Sign Language Translators and Interpreters (SLTIs using current reflections and traditional longstanding concepts of the profession. Even locating interpreters of oral languages and of sign languages in the same chronological line, one should note the significant and clear differences between the two. Based on Rodrigues and Burgos (2001, and on the experiences of Brazilian SLTIs, we outline and highlight the characteristics that differentiate professionals working specifically with oral language from those in SLTI. It is important to mention that the result of the linguistic modality of signed language means that the competence of the SLTI appears to be invisible, thus making it difficult for professionals in this field to be recognized. It is very common for SLTIs to be understood as simply collaborators or facilitators of communication, while the reality is that the functions of the SLTI are much more extensive. By having to deal with the peculiarities of sign language, the SLTI needs to acquire some of its fundamental elements and have exhaustive experience at the frontier of two cultures, as well as bearing responsibilities that are elements in the construction of his or her subjectivity. By presenting questions to those who operate in this field, we highlight the difficulties found in their experiences with the language, with the practice of translating and interpreting, and above all, with the hearing impaired community. We highlight the educational routes that these SLTIs have taken to become professionals in order to guarantee their visibility.

  2. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  3. Temporal Variations in Surface Concentrations of Terrestrial Lead 210 and Uranium 235 Radionucleides

    Science.gov (United States)

    Yoshimori, M.

    We have started to measure the surface concentrations of terrestrial radionucleides of lead 210 and uranium 235 in Tokyo (N35, E139) in 2002. Lead 210 which is a daughter nucleus of Rn-222 (uranium series) emits 46 keV gamma-ray with a half-life of 22.4 years, while uranium 235 (actinium series) emits a gamma-ray at 186 keV with a half-life of 0.7 billion years. The present measurement of the surface concentration of lead 210 exhibits two peaks in spring and fall, similar to the beryllium 7 seasonal variations, while the uranium 235 concentration does not vary with time within statistical errors. These two terrestrial radionucleides exhibit different temporal variations on the surface. We discuss possible explanations for the differences in the temporal variations from a point of view of differences in their altitude distribution.

  4. Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion

    Science.gov (United States)

    Ferrer, R.; Barzakh, A.; Bastin, B.; Beerwerth, R.; Block, M.; Creemers, P.; Grawe, H.; de Groote, R.; Delahaye, P.; Fléchard, X.; Franchoo, S.; Fritzsche, S.; Gaffney, L. P.; Ghys, L.; Gins, W.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Loiselet, M.; Lutton, F.; Moore, I. D.; Martínez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Raeder, S.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Thomas, J-C; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2017-01-01

    Resonant laser ionization and spectroscopy are widely used techniques at radioactive ion beam facilities to produce pure beams of exotic nuclei and measure the shape, size, spin and electromagnetic multipole moments of these nuclei. However, in such measurements it is difficult to combine a high efficiency with a high spectral resolution. Here we demonstrate the on-line application of atomic laser ionization spectroscopy in a supersonic gas jet, a technique suited for high-precision studies of the ground- and isomeric-state properties of nuclei located at the extremes of stability. The technique is characterized in a measurement on actinium isotopes around the N=126 neutron shell closure. A significant improvement in the spectral resolution by more than one order of magnitude is achieved in these experiments without loss in efficiency. PMID:28224987

  5. Origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department); Origine des elements de la famille de l'uranium-235 observes dans la riviere Ellez a proximite du reacteur nucleaire experimental EL4 en cours de demantelement (Mont d'Arree - departement du Finistere). Resultats et premiers constats annee 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 ({sup 227}Ac), non born by its ascendents which are {sup 235}U and {sup 231}Pa is observed. This phenomenon is characterized by mass activities superior to these ones of {sup 235}U and able to reach these ones of {sup 238}U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil ({sup 210}Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  6. Evaluation of total effective dose due to certain environmentally placed naturally occurring radioactive materials using a procedural adaptation of RESRAD code.

    Science.gov (United States)

    Beauvais, Z S; Thompson, K H; Kearfott, K J

    2009-07-01

    Due to a recent upward trend in the price of uranium and subsequent increased interest in uranium mining, accurate modeling of baseline dose from environmental sources of radioactivity is of increasing interest. Residual radioactivity model and code (RESRAD) is a program used to model environmental movement and calculate the dose due to the inhalation, ingestion, and exposure to radioactive materials following a placement. This paper presents a novel use of RESRAD for the calculation of dose from non-enhanced, or ancient, naturally occurring radioactive material (NORM). In order to use RESRAD to calculate the total effective dose (TED) due to ancient NORM, a procedural adaptation was developed to negate the effects of time progressive distribution of radioactive materials. A dose due to United States' average concentrations of uranium, actinium, and thorium series radionuclides was then calculated. For adults exposed in a residential setting and assumed to eat significant amounts of food grown in NORM concentrated areas, the annual dose due to national average NORM concentrations was 0.935 mSv y(-1). A set of environmental dose factors were calculated for simple estimation of dose from uranium, thorium, and actinium series radionuclides for various age groups and exposure scenarios as a function of elemental uranium and thorium activity concentrations in groundwater and soil. The values of these factors for uranium were lowest for an adult exposed in an industrial setting: 0.00476 microSv kg Bq(-1) y(-1) for soil and 0.00596 microSv m(3) Bq(-1) y(-1) for water (assuming a 1:1 234U:238U activity ratio in water). The uranium factors were highest for infants exposed in a residential setting and assumed to ingest food grown onsite: 34.8 microSv kg Bq(-1) y(-1) in soil and 13.0 microSv m(3) Bq(-1) y(-1) in water.

  7. 两种稀土产品中放射性核素分析研究%ANALYSIS OF RADIONUCLIDES IN TWO RARE EARTH PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    周程; 孙恋君

    2009-01-01

    利用高纯锗γ谱仪对两个稀土产品氯化镧和氯化钇的样品进行能谱分析,研究经湿法冶炼工艺后的稀土产品中放射性核素的活度变化.结果表明,样品中存在天然放射性钍系和锕-铀系的核素,以及天然放射性核素~(138)La和~(176)Lu,但两个样品中所含的放射性核素不相同.氯化镧产品中锕-铀系和钍系核素放射性未达平衡,其主要子体~(224)Ra和~(227)Th的含量随时间发生明显变化,约60天达到平衡;而氯化钇产品没有这种现象.%This paper describes a study on raidoactivity change of rare-earth products after hydrometallurgy technology,using HPGe gamma spectrometer to analyze two rare earth products (LaCl_3 and YCl_3).The results show that in the two samples exist natural radionuclides of thorium series and actinium-uranium series as well as other natural radionuclides 138 La and 176 Lu.In the sample of lanthanum chloride the radioactivity of actinium-uranium series and thorium series has not reached balance,the contents of their main progenies ~(226)Ra and ~(227)Th obviously changes with the time,reaching balance 60 days later,while YCl_3 keeps stability.

  8. EST Table: FS844440 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS844440 E_FL_fner_20M15_F_0 10/09/28 100 %/207 aa gb|ACY95331.1| ribosomal protein...0 90 %/207 aa gnl|Amel|GB17629-PA 10/09/10 88 %/207 aa gi|91083393|ref|XP_967983.1| PREDICTED: similar to ribosomal protein L8e [Tribolium castaneum] FS794442 fner ...

  9. 49 CFR 178.360-4 - Closure devices.

    Science.gov (United States)

    2010-10-01

    ... the body of the 2R vessel per (ANSI) Standard B16.5 or (AWWA) Standard C207-55, section 10 (IBR, see...) For nominal pipe sizes, 6, 8, 10, and 12 inches, AWWA Standard C207-55, Table 1, class B, may be used..., nominal pipe size, the following table with the same configuration as illustrated in AWWA C207-55, Table...

  10. Dicty_cDB: Contig-U00979-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tttttttaatgaacnaa 134 Query: 135 naaattcnagtaaaatcnaaagagnttatgatattaccnatgntntaagnccnttaggtc 194 ||||||||||...|||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 135 naaattcnagtaaaatcnaaagagnttatgatattaccnatgntnt...) Strand = Plus / Minus Query: 125 aatgaacnaanaaattcnagtaaaatcnaaagagnttatgatattaccna...agtaaaatcnaaagagnttatgatattaccnatgntntaagn 25 Query: 185 ccnttaggtctaatccgnaaaac 207 |||||||||||||||||||||||

  11. EPA STANDARDS NETWORK FACT SHEET: ISO 14000: INTERNATIONAL ENVIRONMENTAL MANAGEMENT STANDARDS

    Science.gov (United States)

    This flyer provides an overview of the ISO 14000 series of International standards, supplying a brief history, structure of the Technical Committee (TC) 207, structure of the U.S. Technical Advisory Group (TAG) to ISO TC-207, status of the Standards development as of June 1997, w...

  12. Full Article: Stoichiometry, Vibrational Modes and Structure of Molten Nb2O5-K2S2O7 Mixtures

    DEFF Research Database (Denmark)

    Boghosian, S.; Borup, F.; Berg, Rolf W.

    1998-01-01

    The dissolution reaction of Nb205 in pure molten K2S207 has been studied and high temperature Raman spectroscopy has been used for determining the vibrational and structural properties of the Nb(V) complex(es) formed according to the reaction Nb205 + n S207(2-) -> complex. By means of a recently ...

  13. 47 CFR Alphabetical Index - Part 73

    Science.gov (United States)

    2010-10-01

    ... (AM) 73.184 Chief operators 73.1870 Children's TV programs 73.4050 (*) Cigarette advertising 73.4055... 73.207 NCE-FM 73.507 Administrative changes in authorizations— FM 73.212 TV 73.615 Advertising... stations, Minimum separation— FM 73.207 NCE-FM 73.507 Combination advertising rates; joint sales...

  14. 47 CFR 73.9009 - Manufacture for exportation.

    Science.gov (United States)

    2010-10-01

    ... (AM) 73.184 Chief operators 73.1870 Children's TV programs 73.4050 (*) Cigarette advertising 73.4055... 73.207 NCE-FM 73.507 Administrative changes in authorizations— FM 73.212 TV 73.615 Advertising... stations, Minimum separation— FM 73.207 NCE-FM 73.507 Combination advertising rates; joint sales...

  15. Case studies of some major oil spills around India

    Digital Repository Service at National Institute of Oceanography (India)

    SenGupta, R.

    stream_size 11 stream_content_type text/plain stream_name I.O_21_Century_Linkage_Networking_1998_207.pdf.txt stream_source_info I.O_21_Century_Linkage_Networking_1998_207.pdf.txt Content-Encoding ISO-8859-1 Content-Type text...

  16. 76 FR 67473 - Stainless Steel Butt-Weld Pipe Fittings from Italy, Malaysia, and The Philippines; Institution of...

    Science.gov (United States)

    2011-11-01

    ...-weld pipe fittings from Italy, Malaysia, and the Philippines (71 FR 71530). The Commission is now...), and part 207, subparts A, D, E, and F (19 CFR part 207), as most recently amended at 74 FR 2847... Philippines (66 FR 11257). Following five-year reviews by Commerce and the Commission, effective December...

  17. Fishery potential of the Thana - Bassein creek system

    Digital Repository Service at National Institute of Oceanography (India)

    Jyothi, E.A.; Nair, V.R.

    stream_size 4 stream_content_type text/plain stream_name J_Indian_Fish_Assoc_20_7.pdf.txt stream_source_info J_Indian_Fish_Assoc_20_7.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  18. Say ‘no’ to carcinogen as contraception alternative

    Directory of Open Access Journals (Sweden)

    Karen Malec

    2012-07-01

    Full Text Available A response to Correspondence to ‘Dienye PO, Gbeneol PK. Contraception as a risk factor for urinary tract infection in Port Harcourt, Nigeria: A case control study. Afr J Prm Health Care Fam Med. 2011;3(1, Art. #207, 4 pages. doi:10.4102/phcfm.v3i1.207

  19. Gclust Server: 198886 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 198886 OSA_@207 Cluster Sequences - 119 no annotation 1 1.00e-60 14.29 0.0 0.0 0.0 0.0 0.0 Show 1988...86 Cluster ID 198886 Sequence ID OSA_@207 Link to cluster sequences Cluster Sequences Link

  20. Excess molar volumes of (an alkanol plus a branched chain ether) at the temperature 298.15 K and the application of the ERAS model

    CSIR Research Space (South Africa)

    Letcher, TM

    1997-12-01

    Full Text Available . 216 TM. Letcher, P.U. Gol;ender/ Fluid Phase Equilibria 140 (1997) 207-220 x Fig. 2 (see p. 214 for caption). T.M. Letcher, P. I/. Gownder/ Fluid Phase Equilibricr 140 C I9971 207-220 (4 Fig. 3 (see p. 214 for caption...