WorldWideScience

Sample records for actinium 206

  1. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  2. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  3. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  4. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Science.gov (United States)

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development.

  5. Relativistic small-core pseudopotentials for actinium, thorium, and protactinium.

    Science.gov (United States)

    Weigand, Anna; Cao, Xiaoyan; Hangele, Tim; Dolg, Michael

    2014-04-03

    Small-core pseudopotentials for actinium, thorium, and protactinium have been energy-adjusted to multiconfiguration Dirac-Hartree-Fock reference data based on the Dirac-Coulomb-Breit Hamiltonian and the Fermi nucleus model. Corresponding optimized valence basis sets of polarized valence quadruple-ζ quality are presented. Atomic test calculations for the first four ionization potentials show satisfactory results at both the Hartree-Fock and the multireference averaged coupled-pair functional level. Highly correlated Fock-space coupled cluster calculations demonstrate that the new pseudopotentials yield ionization potentials, which are in excellent agreement with corresponding all-electron results and experimental data. The pseudopotentials and basis sets supplement a similar set previously published for uranium.

  6. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  7. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Energy Technology Data Exchange (ETDEWEB)

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  8. Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

    Science.gov (United States)

    Radchenko, V; Engle, J W; Wilson, J J; Maassen, J R; Nortier, F M; Taylor, W A; Birnbaum, E R; Hudston, L A; John, K D; Fassbender, M E

    2015-02-06

    Actinium-225 (t1/2=9.92d) is an α-emitting radionuclide with nuclear properties well-suited for use in targeted alpha therapy (TAT), a powerful treatment method for malignant tumors. Actinium-225 can also be utilized as a generator for (213)Bi (t1/2 45.6 min), which is another valuable candidate for TAT. Actinium-225 can be produced via proton irradiation of thorium metal; however, long-lived (227)Ac (t1/2=21.8a, 99% β(-), 1% α) is co-produced during this process and will impact the quality of the final product. Thus, accurate assays are needed to determine the (225)Ac/(227)Ac ratio, which is dependent on beam energy, irradiation time and target design. Accurate actinium assays, in turn, require efficient separation of actinium isotopes from both the Th matrix and highly radioactive activation by-products, especially radiolanthanides formed from proton-induced fission. In this study, we introduce a novel, selective chromatographic technique for the recovery and purification of actinium isotopes from irradiated Th matrices. A two-step sequence of cation exchange and extraction chromatography was implemented. Radiolanthanides were quantitatively removed from Ac, and no non-Ac radionuclidic impurities were detected in the final Ac fraction. An (225)Ac spike added prior to separation was recovered at ≥ 98%, and Ac decontamination from Th was found to be ≥ 10(6). The purified actinium fraction allowed for highly accurate (227)Ac determination at analytical scales, i.e., at (227)Ac activities of 1-100 kBq (27 nCi to 2.7 μCi).

  9. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  10. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Energy Technology Data Exchange (ETDEWEB)

    Raeder, S., E-mail: s.raeder@gsi.de [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Bastin, B. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Block, M. [Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Institut für Kernchemie, Johannes Gutenberg Universität, 55128 Mainz (Germany); Creemers, P. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Ferrer, R. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fléchard, X. [LPC Caen, ENSICAEN, Université de Caen, CNRS/IN2P3, Caen (France); Franchoo, S. [Institute de Physique Nucléaire (IPN) d’Orsay, 91406 Orsay, Cedex (France); Ghys, L. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); SCK-CEN, Belgian Nuclear Research Center, Boeretang 200, 2400 Mol (Belgium); Gaffney, L.P.; Granados, C. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Heinke, R. [Institut für Physik, Johannes Gutenberg Universität, 55128 Mainz (Germany); Hijazi, L. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); and others

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  11. 75 FR 52914 - Airworthiness Directives; Bell Helicopter Textron Canada Limited Models 206A, 206B, 206L, 206L-1...

    Science.gov (United States)

    2010-08-30

    ... distribution of power and responsibilities among the various levels of government. For the reasons discussed... the AD docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... Service Bulletin No. 206L-09- 157, REV A, dated June 10, 2009, as applicable. (1) Check the...

  12. 14 CFR 206.1 - Emergency transportation.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Emergency transportation. 206.1 Section 206.1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS... EXEMPTIONS § 206.1 Emergency transportation. Notwithstanding the provisions of section 41101 of the...

  13. 10 CFR 490.206 - Violations.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Violations. 490.206 Section 490.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.206 Violations. Violations of this subpart are subject to investigation and enforcement under...

  14. 10 CFR 611.206 - Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Existing facilities. 611.206 Section 611.206 Energy... PROGRAM Facility/Funding Awards § 611.206 Existing facilities. The Secretary shall, in making awards to those manufacturers that have existing facilities, give priority to those facilities that are oldest...

  15. 19 CFR 201.206 - Administrative offset.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Administrative offset. 201.206 Section 201.206... Collection § 201.206 Administrative offset. (a) Collection. The Director may collect a claim pursuant to 31 U... Government by administrative offset of monies payable by the Government. Collection by administrative...

  16. 12 CFR 206.3 - Prudential standards.

    Science.gov (United States)

    2010-01-01

    ... shall establish policies and procedures that take into account credit and liquidity risks, including... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Prudential standards. 206.3 Section 206.3 Banks... INTERBANK LIABILITIES (REGULATION F) § 206.3 Prudential standards. (a) General. A bank shall establish...

  17. 24 CFR 904.206 - Funding.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Funding. 904.206 Section 904.206... HOUSING HOMEOWNERSHIP OPPORTUNITIES Homeownership Counseling and Training § 904.206 Funding. (a) Source of funds. For purpose of funding counseling and training pursuant to this subpart and for establishing...

  18. 5 CFR 295.206 - Final determination.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Final determination. 295.206 Section 295.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS TESTIMONY BY OPM... for Testimony and Production of Documents § 295.206 Final determination. The General Counsel makes...

  19. 13 CFR 400.206 - Environmental requirements.

    Science.gov (United States)

    2010-01-01

    ... projects can be obtained from the Board by contacting: Executive Director, Emergency Steel Guarantee Loan....206 Section 400.206 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Steel Guarantee Loans § 400.206 Environmental requirements. (a)(1)...

  20. 40 CFR 240.206 - Vectors.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Vectors. 240.206 Section 240.206 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.206 Vectors....

  1. 44 CFR 206.17 - Effective date.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Effective date. 206.17 Section 206.17 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE General § 206.17 Effective date....

  2. 24 CFR 206.41 - Counseling.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Counseling. 206.41 Section 206.41... CONVERSION MORTGAGE INSURANCE Eligibility; Endorsement Eligible Mortgagors § 206.41 Counseling. (a) List... receive counseling. (b) Information to be provided. A counselor must discuss with the mortgagor: (1)...

  3. 40 CFR 90.206 - Trading.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Trading. 90.206 Section 90.206... Trading Provisions § 90.206 Trading. (a) An engine manufacturer may exchange emission credits with other engine manufacturers in trading, subject to the trading restriction specified in § 90.207(c)(2)....

  4. 40 CFR 89.206 - Trading.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Trading. 89.206 Section 89.206... EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION ENGINES Averaging, Banking, and Trading Provisions § 89.206 Trading. (a) Requirements for Tier 1 engines rated at or above 37 kW. (1) A...

  5. 40 CFR 91.206 - Trading.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Trading. 91.206 Section 91.206... EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Averaging, Banking, and Trading Provisions § 91.206 Trading. (a... manufacturers in trading. These credits must be used in the same averaging set as generated. (b) Credits...

  6. 44 CFR 206.341 - Policy.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Policy. 206.341 Section 206... SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Coastal Barrier Resources Act § 206.341 Policy. It shall be the policy of FEMA to achieve the goals of CBRA in carrying out disaster relief on units of...

  7. 44 CFR 206.3 - Policy.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Policy. 206.3 Section 206.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE General § 206.3 Policy. It is the policy of FEMA to...

  8. Dicty_cDB: VSC206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VS (Link to library) VSC206 (Link to dictyBase) - - - Contig-U16090-1 VSC206Z (Link... to Original site) - - VSC206Z 495 - - - - Show VSC206 Library VS (Link to library) Clone ID VSC206 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/VS/VSC2-A/VSC206Q.Seq.d/ Representative seq. ID VSC20...6Z (Link to Original site) Representative DNA sequence >VSC206 (VSC206Q) /CSM/VS/VSC2-A/VSC206Q.Seq.d/ XXXXX...fssxp*tpqirchgrikeqt rlys*s*ssrfhgktspnfslqkwscqinpsrscfnqr*thpcw*tisqrsifprpc*ip kalrfsfnlpiswwssrsscp*ngqe

  9. 44 CFR 206.151 - Food commodities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Food commodities. 206.151 Section 206.151 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Food commodities. (a) The Administrator will assure that adequate stocks of food will be ready...

  10. 44 CFR 206.200 - General.

    Science.gov (United States)

    2010-10-01

    ... to State and Local Governments,” published at 44 CFR part 13, place requirements on the State in its... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false General. 206.200 Section 206.200 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF...

  11. 44 CFR 206.32 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 206.32 Section 206.32 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... the FEMA-State Agreement and published in the Federal Register....

  12. 44 CFR 206.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... and emergencies declared by the President before November 23, 1988 were published in 44 CFR part 205... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 206.1 Section 206.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND...

  13. 44 CFR 206.372 - Responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 206.372 Section 206.372 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Responsibilities. (a) The local government shall submit the financial information required by FEMA in...

  14. 44 CFR 206.362 - Responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 206.362 Section 206.362 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Responsibilities. (a) The local government shall submit the financial information required by FEMA in...

  15. 19 CFR 206.52 - Monitoring.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Monitoring. 206.52 Section 206.52 Customs Duties... section 203 of the Trade Act remains in effect, the Commission will monitor developments with respect to... at any time during an investigation under this section with respect to an article that was...

  16. 44 CFR 206.438 - Project management.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Project management. 206.438 Section 206.438 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Project management. (a) General. The State serving as grantee has primary responsibility for...

  17. 24 CFR 206.23 - Shared appreciation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Shared appreciation. 206.23 Section... CONVERSION MORTGAGE INSURANCE Eligibility; Endorsement Eligible Mortgages § 206.23 Shared appreciation. (a) Additional interest based on net appreciated value. Any mortgage for which the mortgagee has chosen...

  18. 12 CFR 206.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... credit and liquidity risks, including operational risks, related to intraday and interday transactions... bank's Tier 1 and Tier 2 capital under the risk-based capital guidelines provided by the bank's primary... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Definitions. 206.2 Section 206.2 Banks...

  19. 38 CFR 3.206 - Divorce.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Divorce. 3.206 Section 3..., Compensation, and Dependency and Indemnity Compensation Evidence Requirements § 3.206 Divorce. The validity of a divorce decree regular on its face, will be questioned by the Department of Veterans Affairs...

  20. 48 CFR 9.206-3 - Competition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Competition. 9.206-3... CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.206-3 Competition. (a) Presolicitation. If a... solicitation to ascertain whether the number of sources is adequate for competition. (See 9.204(a) for...

  1. 30 CFR 206.10 - Information collection.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Information collection. 206.10 Section 206.10 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT... requirements contained in this part have been approved by the Office of Management and Budget (OMB) under 44...

  2. 42 CFR 93.206 - Debarring official.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Debarring official. 93.206 Section 93.206 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  3. 7 CFR 765.206 - Junior liens.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Junior liens. 765.206 Section 765.206 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... determinations for future requests for assistance and may adversely impact such requests. (b) Conditions...

  4. 5 CFR 330.206 - Job consideration.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Job consideration. 330.206 Section 330..., SELECTION, AND PLACEMENT (GENERAL) Reemployment Priority List (RPL) § 330.206 Job consideration. (a)(1) An eligible employee under § 330.203 is entitled to consideration for positions in the commuting area...

  5. 5 CFR 430.206 - Planning performance.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Planning performance. 430.206 Section 430.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERFORMANCE MANAGEMENT Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees §...

  6. 44 CFR 206.204 - Project performance.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Project performance. 206.204... § 206.204 Project performance. (a) General. This section describes the policies and procedures applicable during the performance of eligible work. (b) Advances of funds. Advances of funds will be made...

  7. 24 CFR 206.205 - Property charges.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Property charges. 206.205 Section... CONVERSION MORTGAGE INSURANCE Servicing Responsibilities § 206.205 Property charges. (a) General. The mortgagor shall pay all property charges consisting of taxes, ground rents, flood and hazard...

  8. 44 CFR 206.225 - Emergency work.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Emergency work. 206.225 Section 206.225 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... that a threat exists, including identification and evaluation of the threat and recommendations of...

  9. z206sc_video_observations

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents video observations from cruise Z206SC for the Santa Barbara Channel region and beyond in southern California. The vector data file is...

  10. 9 CFR 206.1 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... defined in this section). Contract type. The classification of contracts or risk management agreements for... STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE SWINE CONTRACT LIBRARY § 206.1 Definitions. The...

  11. 30 CFR 206.155 - Accounting for comparison.

    Science.gov (United States)

    2010-07-01

    ... settlement without resorting to processing determined pursuant to § 206.102 of this subpart; or (2) the value... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Accounting for comparison. 206.155 Section 206... MANAGEMENT PRODUCT VALUATION Federal Gas § 206.155 Accounting for comparison. (a) Except as provided...

  12. Star Formation in Henize 206

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] IRA-MIPS Composite [figure removed for brevity, see original site] Visible [figure removed for brevity, see original site] IRAC [figure removed for brevity, see original site] MIPS The LMC is a small satellite galaxy gravitationally bound to our own Milky Way. Yet the gravitational effects are tearing the companion to shreds in a long-playing drama of 'intergalactic cannibalism.' These disruptions lead to a recurring cycle of star birth and star death. Astronomers are particularly interested in the LMC because its fractional content of heavy metals is two to five times lower than is seen in our solar neighborhood. [In this context, 'heavy elements' refer to those elements not present in the primordial universe. Such elements as carbon, oxygen and others are produced by nucleosynthesis and are ejected into the interstellar medium via mass loss by stars, including supernova explosions.] As such, the LMC provides a nearby cosmic laboratory that may resemble the distant universe in its chemical composition. The primary Spitzer image, showing the wispy filamentary structure of Henize 206, is a four-color composite mosaic created by combining data from an infrared array camera (IRAC) at near-infrared wavelengths and the mid-infrared data from a multiband imaging photometer (MIPS). Blue represents invisible infrared light at wavelengths of 3.6 and 4.5 microns. Note that most of the stars in the field of view radiate primarily at these short infrared wavelengths. Cyan denotes emission at 5.8 microns, green depicts the 8.0 micron light, and red is used to trace the thermal emission from dust at 24 microns. The separate instrument images are included as insets to the main composite. An inclined ring of emission dominates the central and upper regions of the image. This delineates a bubble of hot, x-ray emitting gas that was blown into space when a massive star died in a supernova explosion millions of years ago. The shock waves

  13. 44 CFR 206.364 - Loan application.

    Science.gov (United States)

    2010-10-01

    ... developed from financial information contained in the local government's annual operating budget (see § 206... Statement of the Applicant's Operating Results—Cash Position, a Debt History, Tax Assessment Data, Financial.... General Fund, etc.) which is included as its annual Operating budget, and (B) A copy of the...

  14. 44 CFR 206.434 - Eligibility.

    Science.gov (United States)

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Hazard Mitigation Grant Program § 206.434... project, no application for additional disaster assistance will be made for any purpose with respect to... which are easily movable (except mobile homes), unimproved, previous parking lots, and buffer zones....

  15. 21 CFR 131.206 - Nonfat yogurt.

    Science.gov (United States)

    2010-04-01

    ...) Concentrated skim milk, nonfat dry milk, buttermilk, whey, lactose, lactalbumins, lactoglobulins, or whey... CONSUMPTION MILK AND CREAM Requirements for Specific Standardized Milk and Cream § 131.206 Nonfat yogurt. (a... addition of bulky flavors, contains less than 0.5 percent milkfat and not less than 8.25 percent...

  16. 5 CFR 720.206 - Selection guidelines.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Selection guidelines. 720.206 Section 720... guidelines. This subpart sets forth requirements for a recruitment program, not a selection program... procedures and criteria must be consistent with the Uniform Guidelines on Employee Selection Procedures...

  17. 44 CFR 206.62 - Available assistance.

    Science.gov (United States)

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Emergency Assistance § 206.62 Available... threat of a catastrophe; (b) Coordinate all disaster relief assistance (including voluntary assistance... Stafford Act; and (g) Assist State and local governments in the distribution of medicine, food, and...

  18. 24 CFR 235.206 - Substitute mortgagors.

    Science.gov (United States)

    2010-04-01

    ... MORTGAGE INSURANCE AND ASSISTANCE PAYMENTS FOR HOME OWNERSHIP AND PROJECT REHABILITATION Contract Rights and Obligations-Homes for Lower Income Families § 235.206 Substitute mortgagors. (a) Selling mortgagor... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Substitute mortgagors....

  19. 44 CFR 206.390 - General.

    Science.gov (United States)

    2010-10-01

    ... SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Fire Suppression Assistance § 206.390 General. When the Assistant Administrator for the Disaster Assistance Directorate determines that a fire or fires threaten such destruction as would constitute a major disaster, assistance may be...

  20. 44 CFR 206.393 - Providing assistance.

    Science.gov (United States)

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Fire Suppression Assistance § 206.393 Providing assistance. Following the Assistant Administrator for the Disaster Assistance Directorate's... requested by the State. For each fire or fire situation, the State shall prepare a separate Fire...

  1. 7 CFR 1160.206 - Procedure.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order National Fluid Milk Processor Promotion Board § 1160.206 Procedure. (a) A majority of the members...

  2. 5 CFR 880.206 - Date of death.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Date of death. 880.206 Section 880.206...) RETIREMENT AND INSURANCE BENEFITS DURING PERIODS OF UNEXPLAINED ABSENCE Procedures § 880.206 Date of death... OPM, the date of death of a missing annuitant who has been determined to be dead by an...

  3. 30 CFR 206.459 - Allocation of washed coal.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Allocation of washed coal. 206.459 Section 206... MANAGEMENT PRODUCT VALUATION Indian Coal § 206.459 Allocation of washed coal. (a) When coal is subjected to washing, the washed coal must be allocated to the leases from which it was extracted. (b) When the...

  4. 30 CFR 206.260 - Allocation of washed coal.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Allocation of washed coal. 206.260 Section 206... MANAGEMENT PRODUCT VALUATION Federal Coal § 206.260 Allocation of washed coal. (a) When coal is subjected to washing, the washed coal must be allocated to the leases from which it was extracted. (b) When the...

  5. 44 CFR 206.226 - Restoration of damaged facilities.

    Science.gov (United States)

    2010-10-01

    ... funding for and require restoration of a destroyed facility at a new location when: (i) The facility is... facilities. 206.226 Section 206.226 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... § 206.226 Restoration of damaged facilities. Work to restore eligible facilities on the basis of...

  6. 23 CFR 230.206 - Monitoring supportive services.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Monitoring supportive services. 230.206 Section 230.206 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS EXTERNAL PROGRAMS Supportive Services for Minority, Disadvantaged, and Women Business Enterprises § 230.206...

  7. 37 CFR 41.206 - Common interests in the invention.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Common interests in the invention. 41.206 Section 41.206 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK... Interferences § 41.206 Common interests in the invention. An administrative patent judge may decline to...

  8. 18 CFR 375.206 - Procedures to close meetings.

    Science.gov (United States)

    2010-04-01

    ... meetings. 375.206 Section 375.206 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Sunshine Act § 375.206 Procedures to close meetings. (a) General rule. A meeting or a portion of a meeting may be closed only when the Commission votes by a majority of the membership to close the meeting....

  9. 29 CFR 1650.206 - Notification to Treasury.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Notification to Treasury. 1650.206 Section 1650.206 Labor... for the Collection of Debts by Federal Tax Refund Offset § 1650.206 Notification to Treasury. (a) When referring a debt to Treasury, EEOC will certify that the debt meets all of the requirements in §...

  10. 40 CFR 86.206-94 - Equipment required; overview.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Equipment required; overview. 86.206-94 Section 86.206-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.206-94 Equipment...

  11. 40 CFR 86.206-11 - Equipment required; overview.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Equipment required; overview. 86.206-11 Section 86.206-11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.206-11 Equipment...

  12. 33 CFR 20.206 - Separation of functions.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Separation of functions. 20.206 Section 20.206 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES... Administrative Law Judges § 20.206 Separation of functions. (a) No ALJ may be responsible to, or supervised...

  13. 30 CFR 75.206 - Conventional roof support.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Conventional roof support. 75.206 Section 75.206 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND... square inches. (d) Materials other than wood used for support shall have support strength at...

  14. 48 CFR 206.302-7 - Public interest.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Public interest. 206.302-7 Section 206.302-7 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM....302-7 Public interest. (c) Limitations. For the defense agencies, the written determination to...

  15. 44 CFR 206.47 - Cost-share adjustments.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Cost-share adjustments. 206.47 Section 206.47 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT... Consumers published annually by the Department of Labor. (c) When we determine whether to recommend a...

  16. 30 CFR 206.464 - Value enhancement of marketable coal.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Value enhancement of marketable coal. 206.464... MANAGEMENT PRODUCT VALUATION Indian Coal § 206.464 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after the coal has been placed...

  17. 30 CFR 206.265 - Value enhancement of marketable coal.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Value enhancement of marketable coal. 206.265... MANAGEMENT PRODUCT VALUATION Federal Coal § 206.265 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after the coal has been placed...

  18. 42 CFR 457.206 - Administrative appeals under CHIP.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Administrative appeals under CHIP. 457.206 Section... Claims; Reduction of Federal Medical Payments § 457.206 Administrative appeals under CHIP. Three distinct... provisions of 42 CFR part 430, subpart D of this chapter. (b) FFP in State CHIP expenditures....

  19. 41 CFR 101-27.206-3 - Packaging.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Packaging. 101-27.206-3 Section 101-27.206-3 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 27-INVENTORY MANAGEMENT...

  20. 41 CFR 101-27.206-1 - General considerations.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true General considerations. 101-27.206-1 Section 101-27.206-1 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 27-INVENTORY MANAGEMENT...

  1. 49 CFR 24.206 - Eviction for cause.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Eviction for cause. 24.206 Section 24.206 Transportation Office of the Secretary of Transportation UNIFORM RELOCATION ASSISTANCE AND REAL PROPERTY... cause. (a) Eviction for cause must conform to applicable State and local law. Any person who...

  2. 27 CFR 25.206 - Removal of beer.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removal of beer. 25.206... OF THE TREASURY LIQUORS BEER Removals Without Payment of Tax Beer for Personal Or Family Use § 25.206 Removal of beer. Beer made under § 25.205 may be removed from the premises where made for personal...

  3. 19 CFR 10.206 - Value content requirement.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Value content requirement. 10.206 Section 10.206 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... liability insurance, advertising, and salesmen's salaries, commissions, or expenses. (f) Articles wholly...

  4. 30 CFR 206.153 - Valuation standards-processed gas.

    Science.gov (United States)

    2010-07-01

    ... Section 206.153 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Gas § 206.153 Valuation standards—processed gas. (a)(1) This section... shall be by letter to the MMS Associate Director for Minerals Revenue Management or his/her...

  5. 30 CFR 206.152 - Valuation standards-unprocessed gas.

    Science.gov (United States)

    2010-07-01

    ... Section 206.152 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Gas § 206.152 Valuation standards—unprocessed gas. (a)(1) This section.... The notification shall be by letter to the MMS Associate Director for Minerals Revenue Management...

  6. 9 CFR 206.2 - Swine contract library.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Swine contract library. 206.2 Section... STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE SWINE CONTRACT LIBRARY § 206.2 Swine contract library. (a) Do... swine contract library will be made available to the public? GIPSA will summarize the information it...

  7. 14 CFR 125.206 - Pitot heat indication systems.

    Science.gov (United States)

    2010-01-01

    ... flight instrument pitot heating system unless the airplane is equipped with an operable pitot heat... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pitot heat indication systems. 125.206... Equipment Requirements § 125.206 Pitot heat indication systems. (a) Except as provided in paragraph (b)...

  8. 27 CFR 27.206 - Bottles not constituting approved containers.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottles not constituting approved containers. 27.206 Section 27.206 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... officer that such bottle is not an approved container for distilled spirits for consumption in the...

  9. 40 CFR 211.206-1 - Real ear method.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Real ear method. 211.206-1 Section 211... PRODUCT NOISE LABELING Hearing Protective Devices § 211.206-1 Real ear method. (a) The value of sound... “Method for the Measurement of Real-Ear Protection of Hearing Protectors and Physical Attenuation...

  10. 44 CFR 206.63 - Provision of assistance.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Provision of assistance. 206.63 Section 206.63 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT... lessen or avert the threat of a catastrophe....

  11. 5 CFR 179.206 - Notice requirements before offset.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Notice requirements before offset. 179.206 Section 179.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... administrative costs including a statement that such assessments must be made unless excused in accordance...

  12. 9 CFR 113.206 - Wart Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Wart Vaccine, Killed Virus. 113.206... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.206 Wart Vaccine, Killed Virus. Wart Vaccine, Killed Virus, shall be...

  13. 29 CFR 1603.206 - Consolidation and severance of hearings.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES FOR PREVIOUSLY EXEMPT STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.206 Consolidation...

  14. 17 CFR 275.206(4)-8 - Pooled investment vehicles.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Pooled investment vehicles... COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.206(4)-8 Pooled investment vehicles. (a) Prohibition. It shall constitute a fraudulent, deceptive, or manipulative...

  15. 30 CFR 206.150 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... PRODUCT VALUATION Federal Gas § 206.150 Purpose and scope. (a) This subpart is applicable to all gas production from Federal oil and gas leases. The purpose of this subpart is to establish the value of production for royalty purposes consistent with the mineral leasing laws, other applicable laws and...

  16. 44 CFR 206.43 - Emergency support teams.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Emergency support teams. 206... Emergency support teams. The Federal Coordinating Officer may activate emergency support teams, composed of... emergency. These emergency support teams assist the FCO in carrying out his/her responsibilities under...

  17. 47 CFR 20.6 - CMRS spectrum aggregation limit.

    Science.gov (United States)

    2010-10-01

    ... COMMERCIAL MOBILE RADIO SERVICES § 20.6 CMRS spectrum aggregation limit. (a) Spectrum limitation. No licensee... interest is held by a small business or a rural telephone company, as these terms are defined in § 1.2110... that is a small business. (3) Investment companies, as defined in 15 U.S.C. 80a-3, insurance...

  18. 30 CFR 206.261 - Transportation allowances-general.

    Science.gov (United States)

    2010-07-01

    ... quantity of clean coal output and the rejected waste material. The transportation allowance shall be... MANAGEMENT PRODUCT VALUATION Federal Coal § 206.261 Transportation allowances—general. (a) For ad valorem... the coal from a Federal lease to a sales point which is remote from both the lease and mine; or...

  19. 30 CFR 206.460 - Transportation allowances-general.

    Science.gov (United States)

    2010-07-01

    ... quantity of clean coal output and the rejected waste material. The transportation allowance shall be... MANAGEMENT PRODUCT VALUATION Indian Coal § 206.460 Transportation allowances—general. (a) For ad valorem... the coal from an Indian lease to a sales point which is remote from both the lease and mine; or...

  20. 27 CFR 555.206 - Location of magazines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Location of magazines. 555... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Storage § 555.206 Location of magazines. (a) Outdoor magazines in which high explosives are stored must be located no closer to...

  1. 30 CFR 206.262 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... REVENUE MANAGEMENT PRODUCT VALUATION Federal Coal § 206.262 Determination of transportation allowances. (a... transporting the coal under that contract, subject to monitoring, review, audit, and possible future adjustment... are generally those for depreciable fixed assets (including costs of delivery and installation...

  2. 12 CFR 206.5 - Capital levels of correspondents.

    Science.gov (United States)

    2010-01-01

    ... capitalized under this section without regard to the minimum leverage ratio required under paragraph (a)(3) of... 206.5 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... standards. See, e.g. 12 CFR part 208, subpart D. (1) A total risk-based capital ratio, as defined...

  3. 44 CFR 206.223 - General work eligibility.

    Science.gov (United States)

    2010-10-01

    ... eligible applicant. (b) Private nonprofit facilities. To be eligible, all private nonprofit facilities must be owned and operated by an organization meeting the definition of a private nonprofit organization... by an eligible applicant, as defined in § 206.222, must be owned by a private nonprofit...

  4. 24 CFR 1003.206 - Program administration costs.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Program administration costs. 1003... Eligible Activities § 1003.206 Program administration costs. ICDBG funds may be used for the payment of... to undertake a specific funded activity are also not considered program administration costs....

  5. 44 CFR 206.391 - FEMA-State Agreement.

    Science.gov (United States)

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Fire Suppression Assistance § 206.391... continuing FEMA-State Agreement for Fire Suppression Assistance (the Agreement) signed by the Governor and... for the Disaster Assistance Directorate may require and specifies the type and extent of...

  6. 48 CFR 1809.206-70 - Small businesses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Small businesses. 1809.206...-70 Small businesses. If a small business otherwise eligible for award has been placed in a special... that the small business does not appear to have the capacity to perform, the certificate of...

  7. 19 CFR 206.66 - Limited disclosure of certain confidential business information under administrative protective...

    Science.gov (United States)

    2010-04-01

    ... business information under administrative protective order. 206.66 Section 206.66 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL... certain confidential business information under administrative protective order. In an investigation...

  8. 10 CFR 835.206 - Limits for the embryo/fetus.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Limits for the embryo/fetus. 835.206 Section 835.206... Exposure § 835.206 Limits for the embryo/fetus. (a) The equivalent dose limit for the embryo/fetus from the... provided in § 835.206(a) shall be avoided. (c) If the equivalent dose to the embryo/fetus is determined...

  9. 44 CFR 206.119 - Financial assistance to address other needs.

    Science.gov (United States)

    2010-10-01

    ... address other needs. 206.119 Section 206.119 Emergency Management and Assistance FEDERAL EMERGENCY... Assistance to Individuals and Households § 206.119 Financial assistance to address other needs. (a) Purpose... disaster-related necessary expenses or serious needs. To qualify for assistance under this section,...

  10. 28 CFR 2.206 - Travel approval and transfers of supervision.

    Science.gov (United States)

    2010-07-01

    ... supervision. 2.206 Section 2.206 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION... Supervised Releasees § 2.206 Travel approval and transfers of supervision. (a) A releasee's supervision officer may approve travel outside the district of supervision without approval of the Commission in...

  11. 48 CFR 206.302-3 - Industrial mobilization; or engineering, development, or research capability.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial mobilization; or engineering, development, or research capability. 206.302-3 Section 206.302-3 Federal Acquisition... COMPETITION REQUIREMENTS Other Than Full and Open Competition 206.302-3 Industrial mobilization;...

  12. 50 CFR 226.206 - Critical habitat for the Southern Resident killer whale (Orcinus orca).

    Science.gov (United States)

    2010-10-01

    ... killer whale (Orcinus orca). 226.206 Section 226.206 Wildlife and Fisheries NATIONAL MARINE FISHERIES... CRITICAL HABITAT § 226.206 Critical habitat for the Southern Resident killer whale (Orcinus orca). Critical habitat is designated for the Southern Resident killer whale as described in this section. The...

  13. 19 CFR 206.17 - Limited disclosure of certain confidential business information under administrative protective...

    Science.gov (United States)

    2010-04-01

    ... Investigations Relating to Global Safeguard Actions § 206.17 Limited disclosure of certain confidential business... business information under administrative protective order. 206.17 Section 206.17 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  14. 44 CFR 206.252 - Insurance requirements for facilities damaged by flood.

    Science.gov (United States)

    2010-10-01

    ... facilities damaged by flood. 206.252 Section 206.252 Emergency Management and Assistance FEDERAL EMERGENCY... Assistance Insurance Requirements § 206.252 Insurance requirements for facilities damaged by flood. (a) Where an insurable building damaged by flooding is located in a special flood hazard area identified...

  15. The Clinical analyse of 206 patients of cerebral infarction (Abstract)

    Institute of Scientific and Technical Information of China (English)

    Mai Mai; Ti Yi Ming; Ghen Bo

    2000-01-01

    This thesis make a summary and analyse to 206 patients of cerebral infarction. The morbidity of the age from 51 to 70 is thehighist in 206 patients. It is 75.3 % a mong the patient that hypertension is original. The frequently-occurring cerebral in farction patient are 36.8 % and it is the highist. Because our hospital have purchased CT machinery, we can early diagnose cerebral infarction and do dissolving thrombus in early time, controlling blood pressure, clearing away free radical, dehydrating, di lating cerebral blood vessel, recovering treat early and so on. It reduced the appear ing of conplication and the death rate and viability by oneselfare improved obvious lv.

  16. Completion report for Well Cluster ER-20-6

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The Well Cluster ER-20-6 drilling and completion project was conducted during February, March, and April of 1996 in support of the Nevada Environmental Restoration Project at the Nevada Test Site (NTS), Nye County, Nevada. This project is part of the DOE`s Underground Test Area (UGTA) subproject at the NTS. The primary UGTA tasks include collecting geological, geophysical, and hydrological data from new and existing wells to define groundwater quality as well as pathways and rates of groundwater migration at the NTS. A program of drilling wells near the sites of selected underground nuclear tests (near-field drilling) was implemented as part of the UGTA subproject to obtain site-specific data on the nature and extent of migration of radionuclides produced by an underground nuclear explosion. The ER-20-6 near-field drilling project was originally planned to be very similar to that recently conducted at Well Cluster ER-20-5, which was designed to obtain data on the existing hydrologic regime near the site of an underground nuclear explosion (IT, 1995; IT, 1996a). However, after further consideration of the goals of the near-field drilling program and the characteristics of the BULLION site, the TWG recommended that the ER-20-6 project be redesigned to accommodate a forced-gradient experiment. This proposed experiment is expected to yield more realistic estimates of transport parameters than can be deduced from sampling and testing natural groundwater flow systems.

  17. MicroRNA-206 regulates surfactant secretion by targeting VAMP-2.

    Science.gov (United States)

    Zhang, Honghao; Guo, Yujie; Mishra, Amarjit; Gou, Deming; Chintagari, Narendranath Reddy; Liu, Lin

    2015-01-01

    Lung surfactant secretion is a highly regulated process. Our previous studies have shown that VAMP-2 is essential for surfactant secretion. In the present study we investigated the role of miR-206 in surfactant secretion through VAMP-2. VAMP-2 was confirmed to be a target of miR-206 by 3'-untranslational region (3'-UTR) luciferase assay. Mutations in the predicated miR-206 binding sites reduced the binding of miR-206 to the 3'-UTR of VAMP-2. miR-206 decreased the expression of VAMP-2 protein and decreased the lung surfactant secretion in alveolar type II cells. In conclusion, miR-206 regulates lung surfactant secretion by limiting the availability of VAMP-2 protein.

  18. Measurement of internal pairs from {sup 206}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, I.; Back, B.B.; Betts, R.R. [and others

    1995-08-01

    The failure to observe sharp sum-energy lines in measurements of {sup 238}U + {sup 181}Ta and {sup 238}U + {sup 232}Th raises the issue of the correct functioning of APEX under in-beam conditions. Extensive measurements with electron and pair emitting sources were used to demonstrate the resolution and acceptance of APEX, but the possibility remains that some unforeseen background or other effects might compromise the ability to see peaks in-beam. In order to test the functioning of APEX under the most stringent conditions, we also performed a measurement of internal pairs produced in the decay of the 2.648-MeV 3{sup -} state in {sup 206}Pb to the 2{sup +} state at 0.803 MeV. The 3{sup -} state was excited in the {sup 206}Pb + {sup 206}Pb reaction at 5.9 MeV/u with a cross section of roughly 40 mb, resulting in an expected pair cross section of approximately 16 {mu}b. It should be emphasized that this measurement represents a much stricter test of the functioning of the apparatus than the observation of sum-energy lines would represent, as the internal pair measurement requires a Doppler shift correction before the transition can be seen. These data were analyzed and clearly show the expected peak. A Doppler-corrected sum-energy spectrum showing the expected IPC line at 823 keV. At present we are evaluating the acceptance of APEX for events of this type but it is clear that the observed yield is close to expectations.

  19. 诺基亚Asha205/206

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    诺基亚一直在不遗余力推出低端入门系列的机型,有人认为它逐渐沦为渣机之王。有人则认为制霸低端市场亦无可厚非。诺基亚最近又“很配合”地推出两款低端新机——Asha 205和206;两款均为非智能机,支持双SIM卡。

  20. Clusters of galaxies associated with quasars. I. 3C 206

    Energy Technology Data Exchange (ETDEWEB)

    Ellingson, E.; Yee, H.K.C.; Green, R.F.; Kinman, T.D. (Steward Observatory, Tucson, AZ (USA); Montreal Universite (Canada); Kitt Peak National Observatory, Tucson, AZ (USA))

    1989-06-01

    Multislit spectroscopy and three-color CCD photometry of the galaxies in the cluster associated with the quasar 3C 206 (PKS 0837-12) at z = 0.198 are presented. This cluster is the richest environment of any low-redshift quasar observed in an Abell richness class 1 cluster. The cluster has a very flattened structure and a very concentrated core about the quasar. Most of the galaxies in this field have colors and luminosities consistent with normal galaxies at this redshift. The background-corrected blue fraction of galaxies is consistent with values for other rich clusters. The existence of several blue galaxies in the concentrated cluster core is an anomaly for a region of such high galaxy density, however, suggesting the absence of a substantial intracluster medium. This claim is supported by the Fanaroff-Riley (1974) class II morphology of the radio source. The velocity dispersion calculated from 11 spectroscopically confirmed cluster members is 500 + or - 110 km/s, which is slightly lower than the average for Abell class 1 clusters. A high frequency of interaction between the quasar host galaxy and cluster core members at low relative velocities, and a low intracluster gas pressure, may comprise a favorable environment for quasar activity. The properties of the cluster of galaxies associated with 3C 206 are consistent with this model. 59 refs.

  1. MicroRNA-206: a promising theranostic marker.

    Science.gov (United States)

    Novák, Jan; Kružliak, Peter; Bienertová-Vašků, Julie; Slabý, Ondřej; Novák, Miroslav

    2014-01-01

    MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-206, which belongs to the group of so-called "myomiRs", is one of the most studied miRs thus far. In addition to being involved in skeletal muscle development and pathology, it has also been established that it is involved in the pathogenesis of numerous diseases including heart failure, chronic obstructive pulmonary disease, Alzheimer's disease and various types of cancers. The aim of this review is to provide a complex overview of microRNA-206, including regulating its expression, a brief description of its known functions in skeletal muscle and a complex overview of its roles in the biology and pathology of other tissues, emphasizing its significant diagnostic and therapeutic potential.

  2. Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206

    KAUST Repository

    Liang, Yu

    2012-06-26

    Zfp206 (also named as Zscan10) belongs to the subfamily of C2H2 zinc finger transcription factors, which is characterized by the N-terminal SCAN domain. The SCAN domain mediates self-association and association between the members of SCAN family transcription factors, but the structural basis and selectivity determinants for complex formation is unknown. Zfp206 is important for maintaining the pluripotency of embryonic stem cells presumably by combinatorial assembly of itself or other SCAN family members on enhancer regions. To gain insights into the folding topology and selectivity determinants for SCAN dimerization, we solved the 1.85 crystal structure of the SCAN domain of Zfp206. In vitro binding studies using a panel of 20 SCAN proteins indicate that the SCAN domain Zfp206 can selectively associate with other members of SCAN family transcription factors. Deletion mutations showed that the N-terminal helix 1 is critical for heterodimerization. Double mutations and multiple mutations based on the Zfp206SCAN-Zfp110SCAN model suggested that domain swapped topology is a possible preference for Zfp206SCAN-Zfp110SCAN heterodimer. Together, we demonstrate that the Zfp206SCAN constitutes a protein module that enables C2H2 transcription factor dimerization in a highly selective manner using a domain-swapped interface architecture and identify novel partners for Zfp206 during embryonal development. 2012 The Author(s).

  3. 30 CFR 206.179 - What general requirements regarding processing allowances apply to me?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What general requirements regarding processing allowances apply to me? 206.179 Section 206.179 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Gas Processing Allowances §...

  4. 30 CFR 206.177 - What general requirements regarding transportation allowances apply to me?

    Science.gov (United States)

    2010-07-01

    ... transportation allowances apply to me? 206.177 Section 206.177 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Gas Transportation Allowances..., transportation from the lease to a gas processing plant off the lease, unit, or communitized area and from...

  5. 30 CFR 206.171 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-07-01

    ... Section 206.171 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Gas § 206.171 What definitions apply to this subpart? The following... the Department of the Interior. BLM means the Bureau of Land Management of the Department of...

  6. 30 CFR 206.101 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-07-01

    ... Section 206.101 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Oil § 206.101 What definitions apply to this subpart? The following...; (iv) The extent of participation by other owners in operations and day-to-day management of a...

  7. 30 CFR 206.51 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-07-01

    ... Section 206.51 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Oil § 206.51 What definitions apply to this subpart? For purposes of this... owners in operations and day-to-day management of a lease, plant, or other facility; and (v)...

  8. 30 CFR 206.107 - How do I request a value determination?

    Science.gov (United States)

    2010-07-01

    ... Section 206.107 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Oil § 206.107 How do I request a value determination? (a) You may... signed by the Assistant Secretary, Land and Minerals Management; or (2) Issue a value determination...

  9. 7 CFR 1486.206 - What is the Quick Response Marketing Fund?

    Science.gov (United States)

    2010-01-01

    ... responsiveness to time-sensitive marketing problems or opportunities, such as a change in an import regime or the... 7 Agriculture 10 2010-01-01 2010-01-01 false What is the Quick Response Marketing Fund? 1486.206... Eligibility, Applications, and Funding § 1486.206 What is the Quick Response Marketing Fund? (a) This fund...

  10. 10 CFR 431.206 - Energy conservation standards and their effective dates.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Energy conservation standards and their effective dates. 431.206 Section 431.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Illuminated Exit Signs Energy Conservation Standards §...

  11. 9 CFR 93.206 - Declaration and other documents for poultry.

    Science.gov (United States)

    2010-01-01

    ... poultry. 93.206 Section 93.206 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY...

  12. 27 CFR 44.206 - To Government vessels and aircraft for consumption as supplies.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false To Government vessels and aircraft for consumption as supplies. 44.206 Section 44.206 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION...

  13. 34 CFR 682.206 - Due diligence in making a loan.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Due diligence in making a loan. 682.206 Section 682.206 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM General Provisions §...

  14. 42 CFR 403.206 - General standards for Medicare supplemental policies.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false General standards for Medicare supplemental policies. 403.206 Section 403.206 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental...

  15. 44 CFR 206.253 - Insurance requirements for facilities damaged by disasters other than flood.

    Science.gov (United States)

    2010-10-01

    ... facilities damaged by disasters other than flood. 206.253 Section 206.253 Emergency Management and Assistance... by disasters other than flood. (a) Prior to approval of a Federal grant for the restoration of a facility and its contents which were damaged by a disaster other than flood, the Grantee shall notify...

  16. 30 CFR 206.110 - How do I determine a transportation allowance under an arm's-length transportation contract?

    Science.gov (United States)

    2010-07-01

    ... under an arm's-length transportation contract? 206.110 Section 206.110 Mineral Resources MINERALS... § 206.110 How do I determine a transportation allowance under an arm's-length transportation contract? (a) If you or your affiliate incur transportation costs under an arm's-length transportation...

  17. 18 CFR 1304.206 - Requirements for community docks, piers, boathouses, or other water-use facilities.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Requirements for community docks, piers, boathouses, or other water-use facilities. 1304.206 Section 1304.206 Conservation of....206 Requirements for community docks, piers, boathouses, or other water-use facilities. (a)...

  18. 40 CFR 262.206 - Labeling and management standards for containers of unwanted material in the laboratory.

    Science.gov (United States)

    2010-07-01

    ... Material for Laboratories Owned by Eligible Academic Entities § 262.206 Labeling and management standards... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Labeling and management standards for containers of unwanted material in the laboratory. 262.206 Section 262.206 Protection of...

  19. 7 CFR 62.206 - Access to program documents and activities.

    Science.gov (United States)

    2010-01-01

    ... Section 62.206 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) LIVESTOCK, MEAT, AND OTHER AGRICULTURAL COMMODITIES (QUALITY SYSTEMS VERIFICATION...

  20. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    Energy Technology Data Exchange (ETDEWEB)

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting, E-mail: zzyuantinggu@126.com

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  1. Nodal promotes mir206 expression to control convergence and extension movements during zebrafish gastrulation.

    Science.gov (United States)

    Liu, Xiuli; Ma, Yuanqing; Zhang, Congwei; Wei, Shi; Cao, Yu; Wang, Qiang

    2013-10-20

    Nodal, a member of the transforming growth factor β (TGF-β) superfamily, has been shown to play a role in mesendoderm induction and gastrulation movements. The activity of Nodal signaling can be modulated by microRNAs (miRNAs) as previously reported, but little is known about which miRNAs are regulated by Nodal during gastrulation. In the present study, we found that the expression of mir206, one of the most abundant miRNAs during zebrafish early embryo development, is regulated by Nodal signaling. Abrogation of Nodal signal activity results in defective convergence and extension (CE) movements, and these cell migration defects can be rescued by supplying an excess of mir206, suggesting that mir206 acts downstream of Nodal signaling to regulate CE movements. Furthermore, in mir206 morphants, the expression of cell adhesion molecule E-cadherin is significantly increased, while the key transcriptional repressor of E-cadherin, snail1a, is depressed. Our study uncovers a novel mechanism by which Nodal-regulated mir206 modulates gastrulation movements in connection with the Snail/E-cadherin pathway.

  2. miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4.

    Science.gov (United States)

    Winbanks, Catherine E; Beyer, Claudia; Hagg, Adam; Qian, Hongwei; Sepulveda, Patricio V; Gregorevic, Paul

    2013-01-01

    microRNAs regulate the development of myogenic progenitors, and the formation of skeletal muscle fibers. However, the role miRNAs play in controlling the growth and adaptation of post-mitotic musculature is less clear. Here, we show that inhibition of the established pro-myogenic regulator miR-206 can promote hypertrophy and increased protein synthesis in post-mitotic cells of the myogenic lineage. We have previously demonstrated that histone deacetylase 4 (HDAC4) is a target of miR-206 in the regulation of myogenic differentiation. We confirmed that inhibition of miR-206 de-repressed HDAC4 accumulation in cultured myotubes. Importantly, inhibition of HDAC4 activity by valproic acid or sodium butyrate prevented hypertrophy of myogenic cells otherwise induced by inhibition of miR-206. To test the significance of miRNA-206 as a regulator of skeletal muscle mass in vivo, we designed recombinant adeno-associated viral vectors (rAAV6 vectors) expressing miR-206, or a miR-206 "sponge," featuring repeats of a validated miR-206 target sequence. We observed that over-expression or inhibition of miR-206 in the muscles of mice decreased or increased endogenous HDAC4 levels respectively, but did not alter muscle mass or myofiber size. We subsequently manipulated miR-206 levels in muscles undergoing follistatin-induced hypertrophy or denervation-induced atrophy (models of muscle adaptation where endogenous miR-206 expression is altered). Vector-mediated manipulation of miR-206 activity in these models of cell growth and wasting did not alter gain or loss of muscle mass respectively. Our data demonstrate that although the miR-206/HDAC4 axis operates in skeletal muscle, the post-natal expression of miR-206 is not a key regulator of basal skeletal muscle mass or specific modes of muscle growth and wasting. These studies support a context-dependent role of miR-206 in regulating hypertrophy that may be dispensable for maintaining or modifying the adult skeletal muscle phenotype

  3. 19 CFR 206.44 - Contents of a petition under section 421(b) or (o) of the Trade Act.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Contents of a petition under section 421(b) or (o) of the Trade Act. 206.44 Section 206.44 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION... the industry are unable to generate adequate capital to finance the modernization of their...

  4. 34 CFR 206.1 - What are the special educational programs for students whose families are engaged in migrant and...

    Science.gov (United States)

    2010-07-01

    ... whose families are engaged in migrant and other seasonal farmwork? 206.1 Section 206.1 Education..., DEPARTMENT OF EDUCATION SPECIAL EDUCATIONAL PROGRAMS FOR STUDENTS WHOSE FAMILIES ARE ENGAGED IN MIGRANT AND OTHER SEASONAL FARMWORK-HIGH SCHOOL EQUIVALENCY PROGRAM AND COLLEGE ASSISTANCE MIGRANT PROGRAM...

  5. 23 CFR 636.206 - How do I evaluate offerors who do not have a record of relevant past performance?

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false How do I evaluate offerors who do not have a record of relevant past performance? 636.206 Section 636.206 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Selection Procedures, Award...

  6. 28 CFR 5.206 - Language and wording of registration statement.

    Science.gov (United States)

    2010-07-01

    ... required to be filed under the Act shall be submitted in the English language. An exhibit may be filed even though it is in a foreign language if it is accompanied by an English translation certified under oath by... OF FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.206 Language and wording of...

  7. 77 FR 30584 - Thirtieth Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data...

    Science.gov (United States)

    2012-05-23

    ... report SG3 report SAE G-10 AI ARP Briefing to SC-206 Plenary 12:30 p.m. Review ConUse Changes 12 June.... Closing Plenary SG1 report SG2 report Decision to approve the ConUse document for release to the PMC...

  8. 30 CFR 206.350 - What is the purpose of this subpart?

    Science.gov (United States)

    2010-07-01

    ... MANAGEMENT PRODUCT VALUATION Geothermal Resources § 206.350 What is the purpose of this subpart? (a) This subpart applies to all geothermal resources produced from Federal geothermal leases issued pursuant to the Geothermal Steam Act of 1970 (GSA), as amended by the Energy Policy Act of 2005 (EPAct) (30 U.S.C. 1001...

  9. 40 CFR 33.206 - Is there a list of certified MBEs and WBEs?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Is there a list of certified MBEs and... PROTECTION AGENCY PROGRAMS Certification § 33.206 Is there a list of certified MBEs and WBEs? EPA OSDBU will maintain a list of certified MBEs and WBEs on EPA OSDBU's Home Page on the Internet. Any interested...

  10. 34 CFR 206.4 - What regulations apply to these programs?

    Science.gov (United States)

    2010-07-01

    ...: (1) 34 CFR part 74 (Administration of Grants to Institutions of Higher Education, Hospitals, and... ENGAGED IN MIGRANT AND OTHER SEASONAL FARMWORK-HIGH SCHOOL EQUIVALENCY PROGRAM AND COLLEGE ASSISTANCE MIGRANT PROGRAM General § 206.4 What regulations apply to these programs? The following regulations...

  11. 19 CFR 206.7 - Confidential business information; furnishing of nonconfidential summaries thereof.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Confidential business information; furnishing of... NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE DIVERSION, AND REVIEW OF RELIEF ACTIONS General § 206.7 Confidential business...

  12. 76 FR 34123 - 25th Meeting: RTCA Special Committee 206: Aeronautical Information and Meteorological Data Link

    Science.gov (United States)

    2011-06-10

    ... limited to space availability. With the approval of the chairmen, members of the public may present oral... issuing this notice to advise the public of a meeting of RTCA Special Committee 206: Aeronautical... with AEEC Systems Architecture & Interface SC 10 a.m. WG1, WG2, and WG3 Meetings 29 June--Wednesday 9...

  13. 31 CFR 206.10 - Operation of and payments from the Cash Management Improvements Fund.

    Science.gov (United States)

    2010-07-01

    ... SERVICE MANAGEMENT OF FEDERAL AGENCY RECEIPTS, DISBURSEMENTS, AND OPERATION OF THE CASH MANAGEMENT IMPROVEMENTS FUND § 206.10 Operation of and payments from the Cash Management Improvements Fund. (a) The Cash... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Operation of and payments from...

  14. 23 CFR 450.206 - Scope of the statewide transportation planning process.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Scope of the statewide transportation planning process....206 Scope of the statewide transportation planning process. (a) Each State shall carry out a continuing, cooperative, and comprehensive statewide transportation planning process that provides...

  15. 42 CFR 84.206 - Particulate tests; respirators with filters; minimum requirements; general.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Particulate tests; respirators with filters... RESPIRATORY PROTECTIVE DEVICES Chemical Cartridge Respirators § 84.206 Particulate tests; respirators with filters; minimum requirements; general. (a) Three respirators with cartridges containing, or...

  16. 17 CFR 275.206(4)-1 - Advertisements by investment advisers.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Advertisements by investment... COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.206(4)-1 Advertisements.... 80b-3), directly or indirectly, to publish, circulate, or distribute any advertisement: (1)...

  17. 40 CFR 61.206 - Distribution and use of phosphogypsum for other purposes.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Distribution and use of phosphogypsum... Emission Standards for Radon Emissions From Phosphogypsum Stacks § 61.206 Distribution and use of phosphogypsum for other purposes. (a) Phosphogypsum may not be lawfully removed from a stack and distributed...

  18. 42 CFR 420.206 - Disclosure of persons having ownership, financial, or control interest.

    Science.gov (United States)

    2010-10-01

    ... this section shall be subject to public disclosure as specified in 20 CFR part 422. ... 42 Public Health 3 2010-10-01 2010-10-01 false Disclosure of persons having ownership, financial... of Ownership and Control Information § 420.206 Disclosure of persons having ownership, financial,...

  19. MiR-206-mediated dynamic mechanism of the mammalian circadian clock

    Directory of Open Access Journals (Sweden)

    Wu Lianqi

    2011-09-01

    Full Text Available Abstract Background As a group of highly conserved small non-coding RNAs with a length of 21~23 nucleotides, microRNAs (miRNAs regulate the gene expression post-transcriptionally by base pairing with the partial or full complementary sequences in target mRNAs, thus resulting in the repression of mRNA translation and the acceleration of mRNA degradation. Recent work has revealed that miRNAs are essential for the development and functioning of the skeletal muscles where they are. In particular, miR-206 has not only been identified as the only miRNA expressed in skeletal muscles, but also exhibited crucial roles in regulation of the muscle development. Although miRNAs are known to regulate various biological processes ranging from development to cancer, much less is known about their role in the dynamic regulation of the mammalian circadian clock. Results A detailed dynamic model of miR-206-mediated mammalian circadian clock system was developed presently by using Hill-type terms, Michaelis-Menten type and mass action kinetics. Based on a system-theoretic approach, the model accurately predicts both the periodicity and the entrainment of the circadian clock. It also explores the dynamics properties of the oscillations mediated by miR-206 by means of sensitivity analysis and alterations of parameters. Our results show that miR-206 is an important regulator of the circadian clock in skeletal muscle, and thus by study of miR-206 the main features of its mediation on the clock may be captured. Simulations of these processes display that the amplitude and frequency of the oscillation can be significantly altered through the miR-206-mediated control. Conclusions MiR-206 has a profound effect on the dynamic mechanism of the mammalian circadian clock, both by control of the amplitude and control or alteration of the frequency to affect the level of the gene expression and to interfere with the temporal sequence of the gene production or delivery. This

  20. Hmgb3 is regulated by microRNA-206 during muscle regeneration.

    Directory of Open Access Journals (Sweden)

    Simona Maciotta

    Full Text Available BACKGROUND: MicroRNAs (miRNAs have been recently involved in most of human diseases as targets for potential strategies to rescue the pathological phenotype. Since the skeletal muscle is a spread-wide highly differentiated and organized tissue, rescue of severely compromised muscle still remains distant from nowadays. For this reason, we aimed to identify a subset of miRNAs major involved in muscle remodelling and regeneration by analysing the miRNA-profile of single fibres isolated from dystrophic muscle, which was here considered as a model of chronic damage. METHODOLOGY/PRINCIPAL FINDINGS: The miRNA-signature associated to regenerating (newly formed and remodelling (resting fibres was investigated in animal models of muscular dystrophies and acute damage, in order to distinguish which miRNAs are primary related to muscle regeneration. In this study we identify fourteen miRNAs associated to dystrophic fibres responsible for muscle regeneration and remodelling, and confirm over-expression of the previously identified regeneration-associated myomiR-206. In particular, a functional binding site for myomiR-206 was identified and validated in the 3'untranslated region (3'UTR of an X-linked member of a family of sequence independent chromatin-binding proteins (Hmgb3 that is preferentially expressed in hematopoietic stem cells. During regeneration of single muscle fibres, Hmgb3 messenger RNA (mRNA and protein expression was gradually reduced, concurrent with the up-regulation of miR-206. CONCLUSION/SIGNIFICANCE: Our results elucidate a negative feedback circuit in which myomiR-206 represses Hmgb3 expression to modulate the regeneration of single muscle fibres after acute and chronic muscle damage. These findings suggest that myomiR-206 may be a potential therapeutic target in muscle diseases.

  1. microRNA-206对人横纹肌肉瘤细胞增殖的影响%Effect of microRNA-206 on proliferation of human rhabdomyosarcoma cells

    Institute of Scientific and Technical Information of China (English)

    陈晓燕; 王教; 王瓯晨

    2009-01-01

    目的 研究microRNA-206在人横纹肌肉瘤细胞A673和A204中的表达以及对细胞增殖的影响.方法 Northern blotting检测正常肌肉组织与人横纹肌肉瘤细胞中microRNA-206表达水平的差异,MTS法检测转染microRNA-206后对细胞增殖的影响.Western blotting检测microRNA-206后对细胞中蛋白水平的影响.结果 Northern blotting结果显示,microRNA-206在正常肌肉组织中高表达,在横纹肌肉瘤细胞A673和A204中不表达;MTS结果表明转染microRNA-206后,横纹肌肉瘤细胞的数目明显减少,microRNA能够明显下调人横纹肌肉瘤细胞中p-ERK的表达.结论 microRNA-206通过ERK信号传导通路抑制横纹肌肉瘤细胞的增殖.

  2. Muscle-specific microRNA-206:research status and prospects%肌肉特异性microRNA-206:研究现状及前景

    Institute of Scientific and Technical Information of China (English)

    郑盼盼; 于新凯; 左群; 李弯弯; 宋亚运

    2015-01-01

      结果与结论:MiR-206能调节神经肌肉损伤后神经肌肉接点的恢复。相关研究显示,控制miR-206水平可能成为治疗肌萎缩侧索硬化症等肌肉疾病的新方法。通过细胞培养发现miR-206能促进卫星细胞的分化,缺乏miR-206会导致卫星细胞延迟分化,在骨骼肌损伤中也发现miR-206能促进骨骼肌的再生。miR-206长期运动适应后水平下降,但当运动适应停训一段时间后,miR-206会恢复到原先的水平,而其机制还有待研究。

  3. microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice

    Science.gov (United States)

    Liu, Ning; Williams, Andrew H.; Maxeiner, Johanna M.; Bezprozvannaya, Svetlana; Shelton, John M.; Richardson, James A.; Bassel-Duby, Rhonda; Olson, Eric N.

    2012-01-01

    Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle–specific microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury. Genetic deletion of miR-206 in mice substantially delayed regeneration induced by cardiotoxin injury. Furthermore, loss of miR-206 accelerated and exacerbated the dystrophic phenotype in a mouse model of Duchenne muscular dystrophy. We found that miR-206 acts to promote satellite cell differentiation and fusion into muscle fibers through suppressing a collection of negative regulators of myogenesis. Our findings reveal an essential role for miR-206 in satellite cell differentiation during skeletal muscle regeneration and indicate that miR-206 slows progression of Duchenne muscular dystrophy. PMID:22546853

  4. Muscles-Specific MicroRNA-206 Targets Multiple Components in Dystrophic Skeletal Muscle Representing Beneficial Adaptations.

    Science.gov (United States)

    Amirouche, Adel; Jahnke, Vanessa E; Lunde, John A; Koulmann, Nathalie; Freyssenet, Damien G; Jasmin, Bernard J

    2016-12-21

    Over the last several years, converging lines of evidence have indicated that miR-206 plays a pivotal role in promoting muscle differentiation and regeneration, thereby potentially impacting positively on the progression of neuromuscular disorders including Duchenne muscular dystrophy (DMD). Despite several studies showing the regulatory function of miR-206 on target mRNAs in skeletal muscle cells, the effects of overexpression of miR-206 in dystrophic muscles remain to be established. Here, we found that miR-206 overexpression in mdx mouse muscles simultaneously targets multiple mRNAs and proteins implicated in satellite cell differentiation, muscle regeneration, and at the neuromuscular junction. Overexpression of miR-206 also increased the levels of several muscle-specific mRNAs/proteins while enhancing utrophin A expression at the sarcolemma. Finally, we also observed that the increase expression of miR-206 in dystrophin-deficient mouse muscle decreased the production of pro-inflammatory cytokines and infiltration of macrophages. Taken together, our results show that miR-206 acts as a pleiotropic regulator that targets multiple key mRNAs and proteins expected to provide beneficial adaptations in dystrophic muscle, thus highlighting its therapeutic potential for DMD.

  5. MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D.

    Science.gov (United States)

    Georgantas, Robert W; Streicher, Katie; Luo, Xiaobing; Greenlees, Lydia; Zhu, Wei; Liu, Zheng; Brohawn, Philip; Morehouse, Christopher; Higgs, Brandon W; Richman, Laura; Jallal, Bahija; Yao, Yihong; Ranade, Koustubh

    2014-03-01

    Expression profiling of microRNAs in melanoma lesional skin biopsies compared with normal donor skin biopsies, as well as melanoma cell lines compared with normal melanocytes, revealed that hsa-miR-206 was down-regulated in melanoma (-75.4-fold, P = 1.7 × 10(-4)). MiR-206 has been implicated in a large number of cancers, including breast, lung, colorectal, ovarian, and prostate cancers; however, its role in tumor development remains largely unknown, its biologic function is poorly characterized, and its targets affecting cancer cells are largely unknown. MiR-206 reduced growth and migration/invasion of multiple melanoma cell lines. Bioinformatics identified cell cycle genes CDK2, CDK4, Cyclin C, and Cyclin D1 as strong candidate targets. Western blots and 3'UTR reporter gene assays revealed that miR-206 inhibited translation of CDK4, Cyclin D1, and Cyclin C. Additionally, hsa-miR-206 transfection induced G1 arrest in multiple melanoma cell lines. These observations support hsa-miR-206 as a tumor suppressor in melanoma and identify Cyclin C, Cyclin D1, and CDK4 as miR-206 targets.

  6. Clinical analysis of 206 cases of acute poisoning in children%206例小儿急性中毒的临床分析

    Institute of Scientific and Technical Information of China (English)

    彭庆明; 邹卫红; 郭毅; 贺丽梅

    2014-01-01

    Objective To investigate the etiology and clinical characteristics of pediatric acute poisoning. Methods The clinical data of 206 cases of acute poisoning in children in our hospital were retrospectively analyzed. Results In 206 patients with poisoning,90 cases (43.7%) were food poisoning,45 cases (21.8%) with drug poisoning, 30 cases (14.6%)of pesticide poisoning,18 cases (8.7%) of rodenticide poisoning,12 cases (5.8%)of chemical poisoning,11 cases (5.3%) of CO poisoning;among them 191 cases were cured or improved,6 cases of death, transferred 5 cases,4 cases gave up treatment. Conclusion Pediatric acute poisoning involving children of all ages,the number of rural areas is more than urban,and most of the digestive tract poisoning,to eating, wrongly as much;prevention and treatment of acute poisoning in children should be based on prevention,treatment time is the key to treatment of acute poisoning.%目的:了解小儿急性中毒的病因及临床特点。方法回顾性分析对本院206例急性中毒患儿的临床资料。结果在206例中毒患儿中,食物中毒90例(43.7%),药物中毒45例(21.8%),农药中毒30例(14.6%),鼠药中毒18例(8.7%),化学品中毒12例(5.8%),CO中毒11例(5.3%);其中治愈好转191例,死亡6例,转院5例,放弃治疗4例。结论小儿急性中毒涉及儿童各年龄段,农村多于城镇,且绝大多数经消化道中毒,以误食、误服为多;小儿急性中毒的防治应以预防为主,救治开始时间是急性中毒抢救治疗的关键。

  7. Design of offline switch mode power based on FSL206MR%基于FSL206MR的离线式开关电源设计

    Institute of Scientific and Technical Information of China (English)

    汤永科; 王勇; 王小亮; 秦磊

    2014-01-01

    The paper introduces a design of offline switch mode power based on the power supply chip FSL206MR which integrates pulse width modulator(PWM)and SenseFET. It analyzes the working process and design program of the feedback circuit and buck topology in detail. The feedback network is composed of NPN transistor MMBT222A and voltage regulator diode BZX84C13. This switch mode power performs well and has many advantages, such as the simple structure, a good result of voltage stabilization and easy encapsulation, so it has the very high value in application.%介绍了一种基于集成 PWM 和 SenseFET 的开关电源芯片 FSL206MR 的离线式开关电源设计,详细分析了反馈电路和降压拓扑的工作过程及设计方案。采用 NPN 晶体三极管 MMBT2222A 和稳压管 BZX84C13组成反馈网络。该开关电源性能优良,具有结构简单、稳压效果好、易封装等优点,具有很高的生产应用价值。

  8. Photolysis of organic pollutants in wastewater with 206 nm UV irradiation

    Institute of Scientific and Technical Information of China (English)

    Zhao Lian Ye; Chang Qing Cao; Jin Cong He; Ren Xi Zhang; Hui Qi Hou

    2009-01-01

    A new-type UV light source (206 nm) was explored for the degradation of organic pollutants in wastewater for the first time. The degradation performances of triphenyltin chloride (TPTC1), dimethyl phthalate (DMP), as well as rhodamine B (RhB) were investigated. The results indicated that removal efficiency of 50 mg/L RhB, 60 mg/L DMP and 120 mg/LTPTC1 can reach 88.6%,92.5% and 89.4% for 60 min, 50 min and 75 min, respectively. By comparison of removal efficiency, we found 206 nm is superior to 253.7 nm UV in wastewater treatment, implying it is an effective, promising, and worthwhile exploring technology to decompose organic pollutants in wastewater.

  9. Coulomb excitation of the two proton-hole nucleus $^{206}$Hg

    CERN Multimedia

    We propose to use Coulomb excitation of the single magic two-proton-hole nucleus $^{206}$Hg. In a single-step excitation both the first 2$^{+}$ and the highly collective octupole 3$^{-}$ states will be populated. Thus, information on both quadrupole and octupole collectivity will be gained in this neutron-rich nucleus. Due to the high beam intensity, we will be able to observe multi-step Coulomb excitation as well, providing further test on theoretical calculations. The results will be used to improve the predictive power of the shell model for more exotic nuclei as we move to lighter N=126 nuclei. The experiment will use the new HIE-ISOLDE facility and the MINIBALL array, and will take advantage of the recently developed $^{206}$Hg beam from the molten lead target.

  10. Tensile Properties of Al-Cu 206 Cast Alloys with Various Iron Contents

    Science.gov (United States)

    Liu, K.; Cao, X.; Chen, X.-G.

    2014-05-01

    The Al-Cu 206 cast alloys with varying alloy compositions ( i.e., different levels of Fe, Mn, and Si) were investigated to evaluate the effect of the iron-rich intermetallics on the tensile properties. It is found that the tensile strength decreases with increasing iron content, but its overall loss is less than 10 pct over the range of 0.15 to 0.5 pct Fe at 0.3 pct Mn and 0.3 pct Si. At similar iron contents, the tensile properties of the alloys with dominant Chinese script iron-rich intermetallics are generally higher than those with the dominant platelet phase. In the solution and artificial overaging condition (T7), the tensile strength of the 206 cast alloys with more than 0.15 pct Fe is satisfactory, but the elongation does not sufficiently meet the minimum requirement of ductility (>7 pct) for critical automotive applications. However, it was found that both the required ductility and tensile strength can be reached at high Fe levels of 0.3 to 0.5 pct for the alloys with well-controlled alloy chemistry and microstructure in the solution and natural aging condition (T4), reinforcing the motivation for developing recyclable high-iron Al-Cu 206 cast alloys.

  11. XMM-Newton view of the N 206 superbubble in the Large Magellanic Cloud

    CERN Document Server

    Kavanagh, Patrick J; Points, Sean D

    2012-01-01

    We perform an analysis of the X-ray superbubble in the N 206 HII region in the Large Magellanic Cloud using current generation facilities to gain a better understanding of the physical processes at work in the superbubble and to improve our knowledge of superbubble evolution. We used XMM-Newton observations of the N 206 region to produce images and extract spectra of the superbubble diffuse emission. Morphological comparisons with Halpha images from the Magellanic Cloud Emission Line Survey were performed, and spectral analysis of the diffuse X-ray emission was carried out. We derived the physical properties of the hot gas in the superbubble based on the results of the spectral analysis. We also determined the total energy stored in the superbubble and compared this to the expected energy input from the stellar population to assess the superbubble growth rate discrepancy for N 206. We find that the brightest region of diffuse X-ray emission is confined by a Halpha shell, consistent with the superbubble model....

  12. Comprehensive gene and microRNA expression profiling reveals miR-206 inhibits MET in lung cancer metastasis.

    Science.gov (United States)

    Chen, Qing-yong; Jiao, De-min; Yan, Li; Wu, Yu-quan; Hu, Hui-zhen; Song, Jia; Yan, Jie; Wu, Li-jun; Xu, Li-qun; Shi, Jian-guo

    2015-08-01

    MiRNAs associated with the metastasis of lung cancer remain largely unexplored. In this study, gene and miRNA expression profiling were performed to analyze the global expression of mRNAs and miRNAs in human high- and low-metastatic lung cancer cell strains. By developing an integrated bioinformatics analysis, six miRNAs (miR-424-3p, miR-450b-5p, miR-335-5p, miR-34a-5p, miR-302b-3p and miR-206) showed higher target gene degrees in the miRNA-gene network and might be potential metastasis-related miRNAs. Using the qRT-PCR method, the six miRNAs were further confirmed to show a significant expression difference between human lung cancer and normal tissue samples. Since miR-206 showed lower expression both in lung cancer tissues and cell lines, it was used as an example for further functional verification. The wound healing assay and transwell invasion assay showed that miR-206 mimics significantly inhibited the cell migration and invasion of the high-metastatic lung cancer 95D cell strain. One of its predicted targets in our miRNA-gene network, MET, was also obviously decreased at the protein level when miR-206 was overexpressed. Instead, miR-206 inhibitors increased MET protein expression, cell migration and invasion of the low-metastatic lung cancer 95C cell strain. Meanwhile, the luciferase assay showed that MET was a direct target of miR-206. Furthermore, MET gene silence showed a similar anti-migration and anti-invasion effect with miR-206 mimics in 95D cells and could partially attenuate the migration- and invasion-promoting effect of miR-206 inhibitors in 95C cells, suggesting that miR-206 targets MET in lung cancer metastasis. Finally, we also demonstrated that miR-206 can significantly inhibit lung cancer proliferation and metastasis in mouse models. In conclusion, our study provided a miRNA-gene regulatory network in lung cancer metastasis and further demonstrated the roles of miR-206 and MET in this process, which enhances the understanding of the

  13. Breeding and selection of jackfruit Yunre-206%菠萝蜜优良单株云热-206的选育研究

    Institute of Scientific and Technical Information of China (English)

    尼章光; 张林辉; 解德宏; 罗心平; 文定良; 俞艳春

    2008-01-01

    介绍了菠萝蜜优良单株云热-206的选育过程及其特征特性.该单株的产量、品质均优于其他单株及当地种植群体,果实椭圆形、中等大,平均单果重2 233.0 g,果皮青绿色;种子长2.957 cm、宽2.052 cm,每公斤果实的种子数较少(40.9粒);成熟时果苞金黄色,果苞长3.951 cm、宽3.256 cm,果苞重比率为72.40%,果苞清香味浓,综合性状优良.

  14. miR-206-3p在小鼠皮肤中的表达及其作用%Expression and distribution of miR-206-3p in mouse skin and its potential roles

    Institute of Scientific and Technical Information of China (English)

    穆原; 周红; 李文艳; 李耀武

    2013-01-01

    Objective To investigate the expression and distribution of miR-206-3p and its target gene Bdnf (brain-derived neurotrophic factor) in mouse skin and the potential roles during the development of skin.Methods The full-thickness back skins of BALB/c mice on the 13.5 dpc (day post coition),15.5 dpc,17.5 dpc,1 dpp (day post partum),4 dpp and 16 weeks were collected respectively.The expression levels of miR-206-3p and BdnfmRNA were measured by real time RT-PCR,and BDNF protein was detected by western blot.The distributions of miR-206-3p and BDNF in tissue were profiled by in situ hybridization (ISH) and immunohistochemistry (IHC) respectively.Results The expression level of miR-206-3p increased gradually until 17.5 dpc and subsequently receded to the similar level of the 13.5 dpc during adult stage.The expression of BDNF protein exhibited in the opposite manner of miR-206-3p but BdnfmRNA remained stable from the 17.5 dpc until adult stage.ISH results showed that the distribution of miR-206-3p was gradually regionalized during the development of skin in the postnatal days and mainly located in the suprabasal layer and periphery of hair follicles,which was adjacent to the regions of BDNF expression at the same stage in a nonoverlapping manner.Conclusion The miR-206-3p may be involved in neurodevelopment of mouse skin through the post-transcriptional regulation of Bdnf.%目的 对小鼠皮肤中miR-206-3p及其靶基因脑源性神经营养因子(Bdnf)进行表达与定位检测,以探讨其在皮肤发育过程中的可能作用.方法 手术剪取13.5 dpc(交配后天数)、15.5 dpc、17.5 dpc胎鼠,1 dpp(出生后天数)、4 dpp乳鼠及16周龄雄鼠的背部全层皮肤,用实时荧光定量RT-PCR检测miR-206-3p与Bdnf mRNA的表达水平,western blot检测BDNF蛋白质表达水平,原位杂交与免疫组化分别检测miR-206-3p与BDNF的组织定位.结果 皮肤中miR-206-3p在胚胎期持续升高,到17.5 dpc后逐渐降低,于成年鼠时回复至13.5 dpc时

  15. 儿童湿疹206例病理分析%Pathological analysis of the misdiagnosis of children with eczema in 206 cases

    Institute of Scientific and Technical Information of China (English)

    张晓岚; 张丹丹; 李东宁

    2015-01-01

    Objective:To summarize the clinical and pathological data of children with eczema,to analyze the related factors of misdiagnosis.Methods:206 patients with clinical diagnosis of childhood eczema were selected.The clinical manifestations and skin pathological examination of patients were analyzed and studied.Results:The pathological diagnosis of 84 patients was non eczema diseases(40.78%).The age,course of disease,onset location of children could influence the disease diagnosis.Conclusion:Because of the lack of accurate complaints and other factors,children with eczema is easy to appear clinical misdiagnosis in clinical.So the pathological examination has a certain significance on the diagnosis of children with eczema.%目的:总结儿童湿疹患者的临床及病理资料,分析其误诊的相关因素。方法:收治临床诊断儿童湿疹患者206例,对患者的临床表现及皮肤病理检查资料进行分析研究。结果:84例患者的病理诊断为非湿疹类疾病(40.78%)。患儿的年龄、病程、发病部位均可影响疾病的诊断。结论:儿童湿疹患者在临床中因缺乏准确的主诉等因素,易出现临床误诊。因此病理检查对儿童湿疹的诊断有着一定的意义。

  16. KINEMATICS OF THE GALACTIC SUPERNOVA REMNANT G206.9+2.3

    Directory of Open Access Journals (Sweden)

    P. Ambrocio-Cruz

    2014-01-01

    Full Text Available Se realiz ́o un estudio cinem ́atico del remanente de supernova gal ́actico G206.9+2.3 (PKS 0646+06 en las l ́ıneas [SII] λ 6717 y 6731 ̊ A. Este es uno de los primeros pasos de un proyecto a largo plazo de determinaci ́on de distancias cinem ́atica s a RSN gal ́acticos con contraparte ́optica. Se obtuvo la distancia cinem ́atica a es ta ne- bulosa, mostrando primero que los filamentos detectados son realmente la contra parte ́optica del RSN en radio. La distancia estimada en este trabajo es ligeramente may or que la distancia de Monoceros. Se estim ́o que G206.9+2.3 est ́a localizada a 2.2 kpc del Sol, en una regi ́on del cielo donde se observan varias nebulosas superpuestas a diferen- tes velocidades. Se midi ́o una velocidad de choque de 86 km s − 1 y un di ́ametro lineal de 18 pc. Finalmente se calcul ́o que la energ ́ıa depositada al medio interestelar p or la explosi ́on de supernova es de 1 . 7 × 10 49 ergs por lo que se concluy ́o que G206.9+2.3 est ́a en la fase radiativa de su evoluci ́on, con una edad de 6 . 4 × 10 4 a ̃nos.

  17. Mechanism of Regulatory Effect of MicroRNA-206 on Connexin 43 in Distant Metastasis of Breast Cancer

    Institute of Scientific and Technical Information of China (English)

    Zi-Jing Lin; Jia Ming; Lu Yang; Jun-Ze Du; Ning Wang; Hao-Jun Luo

    2016-01-01

    Background: MicroRNA-206 (miR-206) and connexin 43 (Cx43) are related with the distant metastasis of breast cancer.It remains unclear whether the regulatory effect of miR-206 on Cx43 is involved in metastasis of breast cancer.Methods: Using quantitative real-time polymerase chain reaction and Western blot, the expressions of miR-206 and Cx43 were determined in breast cancer tissues, hepatic and pulmonary metastasis (PM), and cell lines (MCF-10A, MCF-7, and MDA-MB-231).MCF-7/MDA-M-231 cells were transfected with lentivirus-shRNA vectors to enhance/inhibit miR-206, and then Cx43 expression was observed.Cell counting kit-8 assay and Transwell method were used to detect their changes in proliferation, migration, and invasion activity.The mutant plasmids of Cx43-3' untranslated region (3'UTR) at position 478-484 and position 1609-1615 were constructed.Luciferase reporter assay was performed to observe the effects of miR-206 on luciferase expression of different mutant plasmids and to confirm the potential binding sites of Cx43.Results: Cx43 protein expression in hepatic and PM was significantly higher than that in the primary tumor, while no significant difference was showed in messenger RNA (mRNA) expression.MiR-206 mRNA expression in hepatic and PM was significantly lower than that in the primary tumor.Cx43 mRNA and protein levels, as well as cell proliferation, migration, and invasion capabilities, were all significantly improved in MDA-MB-231 cells after reducing miR-206 expression but decreased in MCF-7 cells after elevating miR-206 expression, which demonstrated a significantly negative correlation between miR-206 and Cx43 expression (P =0.03).MiR-206 can drastically decrease Cx43 expression of MCF-7 cells but exerts no effects on Cx43 expression in 293 cells transfected with the Cx43 coding region but the lack of Cx43-3'UTR, suggesting that Cx43-3'UTR may be the key in Cx43 regulated by miR-206.Luciferase expression showed that the inhibition efficiency was

  18. Processing and geologic analysis of conventional cores from well ER-20-6 No. 1, Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Prothro, L.B., Townsend, M.J.; Drellack, S.L. Jr. [and others

    1997-09-01

    In 1996, Well Cluster ER-20-6 was drilled on Pahute Mesa in Area 20, in the northwestern corner of the Nevada Test Site (NTS). The three wells of the cluster are located from 166 to 296 meters (m) (544 to 971 feet [ft]) southwest of the site of the underground nuclear test code-named BULLION, conducted in 1990 in Emplacement Hole U-20bd. The well cluster was planned to be the site of a forced-gradient experiment designed to investigate radionuclide transport in groundwater. To obtain additional information on the occurrence of radionuclides, nature of fractures, and lithology, a portion of Well ER-20-6 No. 1, the hole closest to the explosion cavity, was cored for later analysis. Bechtel Nevada (BN) geologists originally prepared the geologic interpretation of the Well Cluster ER-20-6 site and documented the geology of each well in the cluster. However, the cores from Well ER-20-6 No. 1 were not accessible at the time of that work. As the forced-gradient experiment and other radio nuclide migration studies associated with the well cluster progressed, it was deemed appropriate to open the cores, describe the geology, and re-package the core for long-term air-tight storage. This report documents and describes the processing, geologic analysis, and preservation of the conventional cores from Well ER20-6 No. 1.

  19. Fatores que influenciaram a evolução de 206 pacientes com traumatismo craniencefálico grave Relevant factors in 206 patients with severe head injury

    Directory of Open Access Journals (Sweden)

    Venâncio Pereira Dantas Filho

    2004-06-01

    Full Text Available A busca de fatores prognósticos para o traumatismo craniencefálico (TCE tem sido alvo de muitos estudos nas últimas décadas. A identificação de indicadores consistentes da evolução destes pacientes tem representado um grande desafio e sua utilidade considerada evidente tanto para orientar o tratamento, quanto para a estimativa do resultado final. Baseados numa casuística de 206 pacientes com TCE grave (8 pontos ou menos pela Escala de Coma de Glasgow - ECG, estudamos a influência de vários fatores sobre a evolução dos pacientes. A gravidade inicial medida pela ECG, a presença de hipertensão intracraniana (níveis acima de 20 mmHg, o tipo de lesão intracraniana e a presença de hipoxia, hipotensão arterial e a associação de hipóxia e hipotensão arterial tiveram influência significativa sobre a evolução dos pacientes. A presença de politraumatismo (pelo menos dois sítios de lesão além do TCE e a idade (acima e abaixo de 40 anos não influenciaram significativamente a evolução dos pacientes desta casuística.The search for head injury prognostic factors has been intense in the last decades. The importance of identification of these factors has been also recognised to treatment orientation and results estimatives. Based on 206 severe head injuried patients series, we analized the influence of factors over the outcome. The initial severity by Glasgow coma scale, the presence of intracranial hypertension (over 20 mmHg, the type of intracranial lesion and the presence of hypoxia, systemic hypotension or both, significantly influenced the results. The presence of multiple traumas (at least two sites of lesion over head injury, as age, did not influence the final results in this series.

  20. Screening of retinopathy in 206 prematurity in Jiaxing%嘉兴市206例早产儿视网膜病变筛查分析

    Institute of Scientific and Technical Information of China (English)

    濮清岚; 周向明; 孙琪; 王虹; 李萍

    2013-01-01

    目的 了解嘉兴市早产儿视网膜病变(ROP)的发病情况.方法 回顾分析在本院出生的ROP的发病率及其特点.结果 接受筛查的早产儿共206例,发生ROP病变16例,均为双眼发病,发病率为7.77%;出生体质量≤1 000 g组、~1 500 g组、~2 000 g组间,发病率差异有统计学意义(χ2=10.37,P0.05)、出生方式(χ2=2.68,P>0.05)、多胎与单胎(χ2=0.21,P>0.05)间发生ROP的发病率,差异无统计学意义.结论 嘉兴市ROP的发病率为7.77%,低出生体质量、低出生胎龄、吸氧、机械通气是ROP发病的重要因素.%Objective To investigate the incidence of retinopathy of prematurity (ROP) in Jiaxing. Methods The records of premature infants who had undergone ROP screening in the maternal and child health care hospital of Jiaxing between January 2011 and December 2011 were reviewed and analyzed. Results A total of 206 premature infants who were less than 34 weeks or whose birth weight ≤2 000 g were treated in NICU. They were screened for ROP until the retina was entirely vascularized. The prevalence of ROP in the study was 7. 77% , the prevalence of ROP in the subgroup with birth weight ≤ 1 000 g was significantly higher than that of the subgroup with weight from 1 000 to 1 500 g and that of the subgroup with birth weight from 1 500 to 2 000 g (x2= 10. 37, P 34 weeks) (x2=29. 66,P 0. 05) ,mode of parturition( x2= 2. 68, P > 0. 05 ) , multiple gestational births or single gestational birth ( x2= 0. 21, P > 0. 05 ) . Conclusions The incidence of ROP was 7. 77% in Jiaxing. Shorter gestational age, lower birth weight, oxygen supplementation and mechanical ventilation were main factors leading to ROP incidence.

  1. LN206井P110油管的腐蚀原因%Corrosion Reason of P110 Tubing Used in LN206 Well

    Institute of Scientific and Technical Information of China (English)

    毛学强; 谢俊峰; 宋文文; 周怀光; 赵密锋; 陈洪

    2013-01-01

    Severe corrosion occurred at thread joint between submersible pump and spill valve of P110 in LN206 well tubing after 43 days service.The reason of the corrosion failure was studied by metallographic examination,chemical composition analysis,and electrochemical test.The results indicated that to the tubing material,no abnormal phase was found according to micro-morphology observation chemical composition met the requirement of API Spec 5CT.The surface damage was observed on the thread,so the corrosive medium go into the crevice at the damage area.The electrochemical test results show that the potential difference between oil well tubing and spill valve is approximately 110 mV.It is concluded that the corrosion was mainly caused by crevice corrosion,galvanic corrosion,and the high concentration of Cl-accelerated the corrosion process.It is suggested to avoid thread damage during joining the oil well tubing and spill valve.It is necessary thread grease to fully fill the crevice between oil well tubing and spill valve avoid the direct contact of dissimilar metals with significant potential difference.%LN206井中P110油管与潜油泵出口处连接泄油阀的丝扣仅使用了43 d就发生严重腐蚀,对其进行了金相、化学分析和腐蚀电位测试.结果表明,油管的金相组织无异常,化学成分符合API Spec 5CT要求;且油管与泄油阀连接的丝扣有损伤现象,存在一定的缝隙,高浓度的Cl促进了腐蚀;油管的铬含量与泄油阀的相差较大,油管与泄油阀间的电位相差约110mV,电偶腐蚀加速丝扣处腐蚀.建议上扣时避免油管与泄油阀两者连接的丝扣发生损伤,并在丝扣上涂抹质量好的螺纹脂将两者丝扣间的缝隙填满,避免电位相差较大的异种材质直接连接.

  2. COL Application Content Guide for HTGRs: Revision to RG 1.206, Part 1 - Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Wayne Moe

    2012-08-01

    A combined license (COL) application is required by the Nuclear Regulatory Commission (NRC) for all proposed nuclear plants. The information requirements for a COL application are set forth in 10 CFR 52.79, “Contents of Applications; Technical Information in Final Safety Analysis Report.” An applicant for a modular high temperature gas-cooled reactor (HTGR) must develop and submit for NRC review and approval a COL application which conforms to these requirements. The technical information necessary to allow NRC staff to evaluate a COL application and resolve all safety issues related to a proposed nuclear plant is detailed and comprehensive. To this, Regulatory Guide (RG) 1.206, “Combined License Applications for Nuclear Power Plants” (LWR Edition), was developed to assist light water reactor (LWR) applicants in incorporating and effectively formatting required information for COL application review (Ref. 1). However, the guidance prescribed in RG 1.206 presumes a LWR design proposal consistent with the systems and functions associated with large LWR power plants currently operating under NRC license.

  3. $^{206}$ Po sources for production and release studies relevant for high power spallation targets

    CERN Multimedia

    The knowledge of the evaporation behaviour of Po is of essential importance for several scientific and technological applications, like accelerator driven systems (ADS) or the LIEBE project at CERN-ISOLDE. Fundamental investigations on the experimental conditions for the formation of volatile Po species as well as on the chemical composition of the volatile compounds are necessary for a safe operation of such facilities. $^{206}$Po, a mainly $\\gamma$- ray-emitting Po isotope with a half-life of 8.8 d, is best suited for model studies, due to the lower radiation hazard compared to the longer-lived $\\alpha$-emitting isotopes $^{208-210}$Po as well as the easy-to-measure $\\gamma$-ray emission. We propose the production of $^{206}$Po samples in several matrices via the implantation of its precursor $^{210}$Fr into selected metal foils at CERN-ISOLDE. Using these samples, experiments will be carried out at PSI studying the volatilization of Po from different matrices under varying chemical conditions.

  4. Measurement of the radiative neutron capture cross section of 206Pb and its astrophysical implications

    CERN Document Server

    Domingo-Pardo, C; Aerts, G; Alvarez, H; Alvarez-Velarde, F; Andriamonje, Samuel A; Andrzejewski, J; Assimakopoulos, Panayiotis; Audouin, L; Badurek, G; Baumann, P; Becvar, F; Berthoumieux, E; Bisterzo, S; Calviño, F; Calviani, M; Cano-Ott, D; Capote, R; Carrapico, C; Cennini, P; Chepel, V; Chiaveri, Enrico; Colonna, N; Cortés, G; Couture, A; Cox, J; Dahlfors, M; David, S; Dillman, I; Dolfini, R; Dridi, W; Durán, I; Eleftheriadis, C; Embid-Segura, M; Ferrant, L; Ferrari, A; Ferreira-Marques, R; Fitzpatrick, L; Frais-Kölbl, H; Fujii, K; Furman, W; Gallino, R; Gonçalves, I; Gonzalez-Romero, E; Goverdovski, A; Gramegna, F; Griesmayer, E; Guerrero, C; Gunsing, F; Haas, B; Haight, R; Heil, M; Herrera-Martínez, A; Igashira, M; Isaev, M; Jericha, E; Kappeler, F; Kadi, Y; Karadimos, D; Karamanis, D; Kerveno, M; Ketlerov, V; Köhler, P; Konovalov, V; Kossionides, E; Krticka, M; Lamboudis, C; Leeb, H; Lindote, A; Lopes, I; Lozano, M; Lukic, S; Marganiec, J; Marrone, S; Massimi, C; Mastinu, P; Mengoni, A; Milazzo, P M; Moreau, C; Mosconi, M; Neves, F; Oberhummer, Heinz; Oshima, M; O'Brien, S; Pancin, J; Papachristodoulou, C; Papadopoulos, C; Paradela, C; Patronis, N; Pavlik, A; Pavlopoulos, P; Perrot, L; Plag, R; Plompen, A; Plukis, A; Poch, A; Pretel, C; Quesada, J; Rauscher, T; Reifarth, R; Rosetti, M; Rubbia, Carlo; Rudolf, G; Rullhusen, P; Salgado, J; Sarchiapone, L; Savvidis, I; Stéphan, C; Tagliente, G; Taín, J L; Tassan-Got, L; Tavora, L; Terlizzi, R; Vannini, G; Vaz, P; Ventura, A; Villamarín, D; Vincente, M C; Vlachoudis, V; Vlastou, R; Voss, F; Walter, S; Wendler, H; Wiescher, M; Wisshak, K

    2007-01-01

    The (n, gamma) cross section of 206Pb has been measured at the CERN n_TOF facility with high resolution in the energy range from 1 eV to 600 keV by using two optimized C6D6 detectors. In the investigated energy interval about 130 resonances could be observed, from which 61 had enough statistics to be reliably analyzed via the R-matrix analysis code SAMMY. Experimental uncertainties were minimized, in particular with respect to (i) angular distribution effects of the prompt capture gamma-rays, and to (ii) the TOF-dependent background due to sample-scattered neutrons. Other background components were addressed by background measurements with an enriched 208Pb sample. The effect of the lower energy cutoff in the pulse height spectra of the C6D6 detectors was carefully corrected via Monte Carlo simulations. Compared to previous 206Pb values, the Maxwellian averaged capture cross sections derived from these data are about 20% and 9% lower at thermal energies of 5 keV and 30 keV, respectively. These new results hav...

  5. Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients

    Directory of Open Access Journals (Sweden)

    Angelini Corrado

    2010-05-01

    Full Text Available Abstract Background MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle regeneration. The goal of this study is to test the hypothesis that myo-miRs (myo = muscle + miR = miRNA expression is altered in muscle from patients affected by myotonic dystrophy type 1 (DM1, the most frequently inherited neuromuscular disease in adults. In order to gain better insights about the role of miRNAs in the DM1 pathogenesis, we have also analyzed the muscular expression of miR-103 and miR-107, which have been identified in silico as attractive candidates for binding to the DMPK mRNA. Methods To this aim, we have profiled the expression of miR-133 (miR-133a, miR-133b, miR-1, miR-181 (miR-181a, miR-181b, miR-181c and miR-206, that are specifically induced during myogenesis in cardiac and skeletal muscle tissues. miR-103 and miR-107, highly expressed in brain, heart and muscle have also been included in this study. QRT-PCR experiments have been performed on RNA from vastus lateralis biopsies of DM1 patients (n = 7 and control subjects (n = 4. Results of miRNAs expression have been confirmed by Northern blot, whereas in situ hybridization technique have been performed to localize misexpressed miRNAs on muscle sections from DM1 and control individuals. Results Only miR-206 showed an over-expression in 5 of 7 DM1 patients (threshold = 2, fold change between 1.20 and 13.22, average = 5.37 compared to the control group. This result has been further confirmed by Northern blot analysis (3.37-fold overexpression, R2 = 0.89. In situ hybridization localized miR-206 to nuclear site both in normal and DM1 tissues. Cellular distribution in DM1 tissues includes also the nuclear regions of centralized nuclei, with a strong signal corresponding to nuclear clumps. Conclusions This work provides, for the first time, evidences about

  6. 30 CFR 206.366 - What is the nominal fee that a State, tribal, or local government lessee must pay for the use of...

    Science.gov (United States)

    2010-07-01

    ..., or local government lessee must pay for the use of geothermal resources? 206.366 Section 206.366... government lessee must pay for the use of geothermal resources? If a State, tribal, or local government... or generation of electricity—the State, tribal, or local government lessee must pay a nominal fee....

  7. 22 CFR 206.4 - Procedure where a decision concerning a demand is not made prior to the time a response to the...

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procedure where a decision concerning a demand is not made prior to the time a response to the demand is required. 206.4 Section 206.4 Foreign... prior to the time a response to the demand is required. If the response to the demand is required...

  8. 30 CFR 206.355 - How do I calculate royalty due on geothermal resources I sell at arm's length to a purchaser for...

    Science.gov (United States)

    2010-07-01

    ... multiplied by the royalty rate in your lease or that BLM prescribes under 43 CFR 3211.18. See § 206.361 for... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I calculate royalty due on geothermal... Geothermal Resources § 206.355 How do I calculate royalty due on geothermal resources I sell at arm's...

  9. 40 CFR 600.206-08 - Calculation and use of FTP-based and HFET-based fuel economy values for vehicle configurations.

    Science.gov (United States)

    2010-07-01

    ... natural gas test fuel. (b) If only one equivalent petroleum-based fuel economy value exists for an... petroleum-based fuel economy for that configuration. (c) If more than one equivalent petroleum-based fuel... HFET-based fuel economy values for vehicle configurations. 600.206-08 Section 600.206-08 Protection...

  10. MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Lin FO

    2014-09-01

    Full Text Available Feiou Lin,1 Linjie Yao,2 Jin Xiao,3 DengFeng Liu,3 Zhenyu Ni11Department of Orthodontics, 2Department of Pedodontics, 3Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People’s Republic of ChinaPurpose: MicroRNA-206 (miR-206 has been proven to be downregulated in many human malignancies and is correlated with tumor progression. However, the roles of miR-206 and its related molecular mechanisms in oral squamous cell carcinoma (OSCC are still unclear. Thus, the aim of this study was to explore the effects of miR-206 in OSCC tumorigenesis and development.Methods: Quantitative real-time polymerase chain reaction was used to detect miR-206 expression in OSCC cell lines and primary tumor tissues. The association of miR-206 expression with clinicopathological factors and prognosis was also analyzed. In addition, the effects of miR-206 on the biological behavior of OSCC cells were investigated. Lastly, the potential regulatory function of miR-206 on K-Ras expression was confirmed.Results: MiR-206 expression was significantly downregulated in OSCC tissue samples and cell lines (both P<0.001. Decreased miR-206 expression was significantly associated with advanced tumor node metastasis (TNM stage, advanced T classifications (ie, size and/or extent of the primary tumor, positive N classification (ie, spread to regional lymph nodes, and shorter overall survival. In addition, upregulation of miR-206 in Tca8113 cells was able to reduce cell proliferation, invasion, and migration and promote cell apoptosis in vitro. Further, K-Ras was confirmed as a direct target of miR-206 by using luciferase reporter assay.Conclusion: These findings indicate that miR-206 may act as a tumor suppressor in OSCC and could serve as a novel therapeutic agent for miR-based therapy.Keywords: miR-206, oral squamous cell carcinoma, prognosis, proliferation, apoptosis, invasion

  11. Coulomb excitation of re-accelerated 208Rn and 206Po beams

    Directory of Open Access Journals (Sweden)

    Grahn T.

    2013-12-01

    Full Text Available In the present study, B(E2; 2+ → 0+ values have been measured in the 208Rn and 206Po nuclei through Coulomb excitation of re-accelerated radioactive beams in inverse kinematics at CERN-ISOLDE. The resulting B(E2; 2+ → 0+ in 208Rn is ∼ 0.08 e2b2. These nuclei lie in, or at the boundary of the region where seniority scheme should persist. However, contributions from collective excitations may be present when moving away from the N = 126 shell closure. To date, surprisingly little is known of the transition probabilities between the low-spin states in this region.

  12. Upgrade of the Cellular General Purpose Monte Carlo Tool FOAM to version 2.06

    CERN Document Server

    Jadach, Stanislaw

    2006-01-01

    FOAM-2.06 is an upgraded version of FOAM, a general purpose, self-adapting Monte Carlo event generator. In comparison with FOAM-2.05, it has two important improvements. New interface to random numbers lets the user to choose from the three "state of the art" random number generators. Improved algorithms for simplical grid need less computer memory; the problem of the prohibitively large memory allocation required for the large number ($>10^6$) of simplical cells is now eliminated -- the new version can handle such cases even on the average desktop computers. In addition, generation of the Monte Carlo events, in case of large number of cells, may be even significantly faster.

  13. Collective 2+ 1 excitations in 206Po and 208,210Rn

    Science.gov (United States)

    Grahn, T.; Pakarinen, J.; Jokiniemi, L.; Albers, M.; Auranen, K.; Bauer, C.; Bernards, C.; Blazhev, A.; Butler, P. A.; Bönig, S.; Damyanova, A.; De Coster, T.; De Witte, H.; Elseviers, J.; Gaffney, L. P.; Huyse, M.; Herzáň, A.; Jakobsson, U.; Julin, R.; Kesteloot, N.; Konki, J.; Kröll, Th.; Lewandowski, L.; Moschner, K.; Peura, P.; Pfeiffer, M.; Radeck, D.; Rahkila, P.; Rapisarda, E.; Reiter, P.; Reynders, K.; Rudiger, M.; Salsac, M.-D.; Sambi, S.; Scheck, M.; Seidlitz, M.; Siebeck, B.; Steinbach, T.; Stolze, S.; Suhonen, J.; Thoele, P.; Thürauf, M.; Warr, N.; Van Duppen, P.; Venhart, M.; Vermeulen, M. J.; Werner, V.; Veselsky, M.; Vogt, A.; Wrzosek-Lipska, K.; Zielińska, M.

    2016-11-01

    In the present study, B(E2; 2+1→ 0+1) values have been measured in the 208,210Rn and 206Po nuclei through Coulomb excitation of re-accelerated radioactive beams in inverse kinematics at CERN-ISOLDE. These nuclei have been proposed to lie in, or at the boundary of the region where the seniority scheme should persist. However, contributions from collective excitations are likely to be present when moving away from the N=126 closed shell. Such an effect is confirmed by the observed increased collectivity of the 2+1→ 0+1 transitions. Experimental results have been interpreted with the aid of theoretical studies carried out within the BCS-based QRPA framework.

  14. Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder

    Science.gov (United States)

    Ohgidani, Masahiro; Kato, Takahiro A.; Haraguchi, Yoshinori; Matsushima, Toshio; Mizoguchi, Yoshito; Murakawa-Hirachi, Toru; Sagata, Noriaki; Monji, Akira; Kanba, Shigenobu

    2017-01-01

    The pathophysiology of bipolar disorder, especially the underlying mechanisms of the bipolarity between manic and depressive states, has yet to be clarified. Microglia, immune cells in the brain, play important roles in the process of brain inflammation, and recent positron emission tomography studies have indicated microglial overactivation in the brain of patients with bipolar disorder. We have recently developed a technique to induced microglia-like (iMG) cells from peripheral blood (monocytes). We introduce a novel translational approach focusing on bipolar disorder using this iMG technique. We hypothesize that immunological conditional changes in microglia may contribute to the shift between manic and depressive states, and thus we herein analyzed gene profiling patterns of iMG cells from three patients with rapid cycling bipolar disorder during both manic and depressive states, respectively. We revealed that the gene profiling patterns are different between manic and depressive states. The profiling pattern of case 1 showed that M1 microglia is dominant in the manic state compared to the depressive state. However, the patterns of cases 2 and 3 were not consistent with the pattern of case 1. CD206, a mannose receptor known as a typical M2 marker, was significantly downregulated in the manic state among all three patients. This is the first report to indicate the importance of shifting microglial M1/M2 characteristics, especially the CD206 gene expression pattern between depressive and manic states. Further translational studies are needed to dig up the microglial roles in the underlying biological mechanisms of bipolar disorder. PMID:28119691

  15. Non-host disease resistance response in pea (Pisum sativum) pods: Biochemical function of DRR206 and phytoalexin pathway localization.

    Science.gov (United States)

    Seneviratne, Herana Kamal; Dalisay, Doralyn S; Kim, Kye-Won; Moinuddin, Syed G A; Yang, Hong; Hartshorn, Christopher M; Davin, Laurence B; Lewis, Norman G

    2015-05-01

    Continually exposed to potential pathogens, vascular plants have evolved intricate defense mechanisms to recognize encroaching threats and defend themselves. They do so by inducing a set of defense responses that can help defeat and/or limit effects of invading pathogens, of which the non-host disease resistance response is the most common. In this regard, pea (Pisum sativum) pod tissue, when exposed to Fusarium solani f. sp. phaseoli spores, undergoes an inducible transcriptional activation of pathogenesis-related genes, and also produces (+)-pisatin, its major phytoalexin. One of the inducible pathogenesis-related genes is Disease Resistance Response-206 (DRR206), whose role in vivo was unknown. DRR206 is, however, related to the dirigent protein (DP) family. In this study, its biochemical function was investigated in planta, with the metabolite associated with its gene induction being pinoresinol monoglucoside. Interestingly, both pinoresinol monoglucoside and (+)-pisatin were co-localized in pea pod endocarp epidermal cells, as demonstrated using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging. In addition, endocarp epidermal cells are also the site for both chalcone synthase and DRR206 gene expression. Taken together, these data indicate that both (+)-pisatin and pinoresinol monoglucoside function in the overall phytoalexin responses.

  16. 75 FR 47588 - Trans Bay Cable, LLC; Notice of Institution of Section 206 Investigation and Refund Effective Date

    Science.gov (United States)

    2010-08-06

    ... Energy Regulatory Commission Trans Bay Cable, LLC; Notice of Institution of Section 206 Investigation and..., concerning the justness and reasonableness of rates proposed by Trans Bay Cable, LLC (Trans Bay) in ] Docket No. ER10-116-000. Trans Bay Cable, LLC, 132 FERC 61,083 (2010). The refund effective date in...

  17. 45 CFR 46.206 - Research involving, after delivery, the placenta, the dead fetus or fetal material.

    Science.gov (United States)

    2010-10-01

    ..., Human Fetuses and Neonates Involved in Research § 46.206 Research involving, after delivery, the placenta, the dead fetus or fetal material. (a) Research involving, after delivery, the placenta; the dead... 45 Public Welfare 1 2010-10-01 2010-10-01 false Research involving, after delivery, the...

  18. Patenting human embryonic stem cells in peril: the decision of the Enlarged Board of Appeal in G 2/06

    NARCIS (Netherlands)

    S.J.R. Bostyn

    2009-01-01

    The Enlarged Board of Appeal has recently decided one of the most sensitive cases it has ever had on its hands, but probably not the last. The referral in the G 2/06 case related to the patentability of human embryonic stem cells (hESC). The main question was whether inventions pertaining to the hES

  19. 33 CFR 157.206 - Dedicated Clean Ballast Tanks Operations Manual for U.S. tank vessels: Submission.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Dedicated Clean Ballast Tanks... MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.206 Dedicated Clean Ballast Tanks Operations Manual for U.S. tank...

  20. 30 CFR 206.112 - What adjustments and transportation allowances apply when I value oil production from my lease...

    Science.gov (United States)

    2010-07-01

    ... (b) of this section, also adjust the NYMEX price or ANS spot price for quality based on premiums or... apply when I value oil production from my lease using NYMEX prices or ANS spot prices? 206.112 Section... I value oil production from my lease using NYMEX prices or ANS spot prices? This section...

  1. 75 FR 71183 - 23rd Meeting: RTCA Special Committee 206: EUROCAE WG 76 Plenary: AIS and MET Data Link Services

    Science.gov (United States)

    2010-11-22

    ... interested public but limited to space availability. With the approval of the chairmen, members of the public... issuing this notice to advise the public of a meeting of RTCA Special Committee 206: EUROCAE WG 76 Plenary... Architecture Recommendations are included in the TOR deliverables. The Concept of Use for AIS and MET Data...

  2. 17 CFR 275.206(4)-4 - Financial and disciplinary information that investment advisers must disclose to clients.

    Science.gov (United States)

    2010-04-01

    ... such action involved: an investment-related business; fraud, false statements, or omissions; wrongful... course of business within the meaning of section 206(4) of the Act (15 U.S.C. 80b-6(4)) for any... caused an investment-related business to lose its authorization to do business; or (ii) Was found to...

  3. A Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy Associated Mutation in Human Cardiac Troponin I (K206I)

    Science.gov (United States)

    Warren, Chad M.; Karam, Chehade N.; Wolska, Beata M.; Kobayashi, Tomoyoshi; de Tombe, Pieter P.; Arteaga, Grace M.; Bos, J. Martijn; Ackerman, Michael J.; Solaro, R. John

    2015-01-01

    Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease characterized by thickening of ventricular walls and decreased left ventricular chamber volume. The majority of HCM-associated mutations are found in genes encoding sarcomere proteins. Herein, we set out to functionally characterize a novel HCM-associated mutation (K206I-TNNI3), and elucidate the mechanism of dysfunction at the level of myofilament proteins. Methods and Results The male index case was diagnosed with HCM after an out-of-hospital cardiac arrest which was followed by comprehensive clinical evaluation, transthoracic echocardiography, and clinical genetic testing. To determine molecular mechanism(s) of the mutant human cardiac troponin I (K206I), we tested the Ca2+ dependence of thin filament-activated myosin-S1-ATPase activity in a reconstituted, regulated, actomyosin system comparing wildtype human troponin complex, 50% mix of K206I/wildtype, or 100% K206I. We also exchanged native troponin detergent extracted fibers with reconstituted troponin containing either wildtype or a 65% mix of K206I/wildtype, and measured force generation. The Ca2+ sensitivity of the myofilaments containing the K206I variant was significantly increased, and when treated with 20 μM EGCG (green tea) was restored back to wildtype levels in ATPase and force measurements. The K206I mutation impairs the ability of the troponin I to inhibit ATPase activity in the absence of Ca-hcTnC (calcium-bound-human cardiac troponin C). The ability of Ca-hcTnC to neutralize the inhibition of K206I was greater than with wildtype TnI. Conclusions Compromised interactions of K206I with actin and hcTnC may lead to impaired relaxation and HCM. PMID:26553696

  4. The Study of Antagonism of Bacillus subtilis JA-206 against Dermatophytes%枯草芽孢杆菌JA-206对皮肤癣菌抑制作用的研究

    Institute of Scientific and Technical Information of China (English)

    吕树娟; 方海红; 刘静; 王明丽

    2007-01-01

    低能离子诱变筛选获得的枯草芽孢杆菌JA-206的发酵粗提液对红色毛癣菌和须毛癣菌有较强的抑菌或杀菌作用,粗提液经高温、蛋白酶处理后仍然有较高的稳定性,将JA-206粗提液经多步分离纯化,得到三种单一纯化产物抗菌肽AFP1、AFP2和AFP3,其中AFP1和AFP3对两种皮肤癣菌显示出明显的抑菌或杀菌作用.

  5. Analysis of 206 ethic reviews in a hospital within 3 years%某医院近3年206项伦理审查分析

    Institute of Scientific and Technical Information of China (English)

    齐松仁; 姚丽波; 孙瑞华

    2011-01-01

    目的通过对某医院伦理委员会近3年206项临床研究伦理审查情况分析,了解医院伦理审查的一般通过率和常见问题.方法查阅伦理会纪录,归类整理并使用ridit的CMH方法和Bootstrap方法统计分析.结果药物试验通过率为36.09%,器械为1 8.42%,课题为14.29%.在伦理审查发现的问题方面,知情同意占63.59%,方案占14.56%,CRF占7.77%,其他占22.82%;国内申办者的问题明显多于国外申办者.药物伦理审查通过率逐年降低,分别是2006年45.83%、2007年38.78%、2008年19.44%,2008年与2006年相比有统计学上的差异,P=0.029.在药物临床试验中修订项目审查国外明显高于国内,P=0.028.结论医院伦理会对临床研究伦理审查十分必要,审查中尤其要关注知情同意书和研究方案等.%Objective To reveal the average pass rate of a general hospital's ethic review and common problems.Methods The records generated by the ethics committee of a hospital in 3 consecutive years were reviewed and analysed with ridit of CMH and Bootstrap statistical methods.Results The pass rate for drug clinical trial is 36.09%,medical instruments 18.42%,and subject evaluation 14.29%.Among the problems,those concerning informed consent take up 63.59%,of protocol 14.56%,of CRF 7.77% and of the others 22.820%.The domestic applicants had more problems than those abroad.Besides,the pass rate of drug trials decreased with year from 45.83% in 2006 to 19.44% in 2008,which was statistically significant (P=0.029).In terms of drug clinical trial,the pass rate of revised projects in foreign countries was significantly higher than the domestic ones (P=0.028).Conclusion Ethics Committee in a hospital plays a very important role in clinical researches.And informed consent and research protocol are very important in the ethic review.

  6. Serum Levels of MicroRNA-206 and Novel Mini-STR Assays for Carrier Detection in Duchenne Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    Mónica Alejandra Anaya-Segura

    2016-08-01

    Full Text Available Duchenne Muscular Dystrophy (DMD is an X-linked neuromuscular disorder in which the detection of female carriers is of the utmost importance for genetic counseling. Haplotyping with polymorphic markers and quantitation of creatine kinase levels (CK allow tracking of the at-risk haplotype and evidence muscle damage, respectively. Such approaches are useful for carrier detection in cases of unknown mutations. The lack of informative markers and the inaccuracy of CK affect carrier detection. Therefore, herein we designed novel mini-STR (Short Tandem Repeats assays to amplify 10 loci within the DMD gene and estimated allele frequencies and the polymorphism information content among other parameters in 337 unrelated individuals from three Mexican populations. In addition, we tested the utility of the assays for carrier detection in three families. Moreover, given that serum levels of miR-206 discern between DMD patients and controls with a high area under the curve (AUC, the potential applicability for carrier detection was assessed. The serum levels of miR-206 of non-carriers (n = 24 and carriers (n = 23 were compared by relative quantitation using real-time PCR (p < 0.05, which resulted in an AUC = 0.80 in the Receiver Operating Characteristic curve analysis. In conclusion, miR-206 has potential as a “liquid biopsy” for carrier detection and genetic counseling in DMD.

  7. Serum Levels of MicroRNA-206 and Novel Mini-STR Assays for Carrier Detection in Duchenne Muscular Dystrophy

    Science.gov (United States)

    Anaya-Segura, Mónica Alejandra; Rangel-Villalobos, Héctor; Martínez-Cortés, Gabriela; Gómez-Díaz, Benjamín; Coral-Vázquez, Ramón Mauricio; Zamora-González, Edgar Oswaldo; García, Silvia; López-Hernández, Luz Berenice

    2016-01-01

    Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disorder in which the detection of female carriers is of the utmost importance for genetic counseling. Haplotyping with polymorphic markers and quantitation of creatine kinase levels (CK) allow tracking of the at-risk haplotype and evidence muscle damage, respectively. Such approaches are useful for carrier detection in cases of unknown mutations. The lack of informative markers and the inaccuracy of CK affect carrier detection. Therefore, herein we designed novel mini-STR (Short Tandem Repeats) assays to amplify 10 loci within the DMD gene and estimated allele frequencies and the polymorphism information content among other parameters in 337 unrelated individuals from three Mexican populations. In addition, we tested the utility of the assays for carrier detection in three families. Moreover, given that serum levels of miR-206 discern between DMD patients and controls with a high area under the curve (AUC), the potential applicability for carrier detection was assessed. The serum levels of miR-206 of non-carriers (n = 24) and carriers (n = 23) were compared by relative quantitation using real-time PCR (p < 0.05), which resulted in an AUC = 0.80 in the Receiver Operating Characteristic curve analysis. In conclusion, miR-206 has potential as a “liquid biopsy” for carrier detection and genetic counseling in DMD. PMID:27529242

  8. The Correlation of CD206, CD209, and Disease Severity in Behçet’s Disease with Arthritis

    Directory of Open Access Journals (Sweden)

    Bunsoon Choi

    2017-01-01

    Full Text Available The purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD. The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1 were analyzed in patients with BD by flow cytometry, and cytokine levels, interleukin- (IL- 18, IL-23, and IL-17A, were compared in plasma. The analysis was performed in active (n=13 and inactive (n=13 stages of BD patients. Rheumatoid arthritis patients (n=19, as a disease control, and healthy control (HC (n=19 were enrolled. The frequencies of CD11b+ and CD32+ cells were significantly increased in active BD patients compared to HC. Disease severity score was correlated to CD11c+, CD206+, and CD209+ in whole leukocytes and CD11b+, CD11c+, CD206+, CD209+, and Dectin-1+ in granulocytes. The plasma levels of IL-17A were significantly different between HC and active BD. IL-18 showed significant difference between active and inactive BD patients. From this study, we concluded the expressions of several pattern recognition receptors were correlated to the joint symptoms of BD.

  9. Brightness temperature and attenuation diversity statistics at 20.6 and 31.65 GHz for the Colorado Research Network

    Science.gov (United States)

    Westwater, Ed R.; Falls, M. J.; Fionda, E.

    1992-01-01

    A limited network of four dual-channel microwave radiometers, with frequencies of 20.6 and 31.65 GHz, was operated in the front range of eastern Colorado from 1985 to 1988. Data, from November 1987 through October 1988 are analyzed to determine both single-station and joint-station brightness temperature and attenuation statistics. Only zenith observations were made. The spatial separations of the stations varied from 50 km to 190 km. Before the statistics were developed, the data were screened by rigorous quality control methods. One such method, that of 20.6 vs. 31.65 GHz scatter plots, is analyzed in detail, and comparisons are made of measured vs calculated data. At 20.6 and 31.65 GHz, vertical attenuations of 5 and 8 dB are exceeded 0.01 percent of the time. For these four stations and at the same 0.01 percent level, diversity gains from 6 to 8 dB are possible with the 50 to 190 km separations.

  10. The Treatment for 206 Cases of Hypokalemia Related Endocrine and Metabolic Diseases%206例低钾血症相关内分泌代谢疾病的治疗分析

    Institute of Scientific and Technical Information of China (English)

    高立平

    2014-01-01

    目的:回顾性分析低钾血症相关内分泌代谢疾病的治疗体会。方法:选取我院收治住院确诊为低血钾症的患者206例作为研究对象,通过辅助检测确定病因,进行治疗。结果:206例患者中,40例为周期性麻痹(19.4%),18例为肾小管酸中毒(8.7%),39例为胃肠道丢失(18.9%),64例甲亢(31.1%),27例为醛固酮增多症(13.1%),8例为Bartter综合征(3.9%),其中疾病患者10例(4.9%)。经积极对症治疗基础疾病,消除诱发低血钾的因素等方案,204例患者低血钾症状纠正,其中2例患者死亡,治疗好转率为99.0%。结论:对于低血钾患者应全面分析病因,对症进行治疗。%Objective:A retrospective analysis for the treatment for 206 cases of hypokalemia related endocrine and metabolic diseases. Methods:206 cases of patients diagnosed as hypokalemia were chosed as research subjects and through the auxiliary testing to determine the causes, and then were given aggressive treatment. Results:Among the 206 patients, 40 cases were periodic paralysis(19.4%), 18 cases were renal tubular acidosis(8.7%), 39 cases were gastrointestinal loss(18.9%), 64 cases were hyperthyroidism(31.1%), 27 cases were aldosteronism ,8 cases of Bartter's syndrome(3.9%), and 10 cases were with other reasons(4.9%).Through the active treatment to eliminate the factors to induce hypokalemia and other programs, 204 cases of patients with symptoms of hypokalemia were corrected, while 2 patients were died, the treatment improvement rate was 99.0%. Conclusion:A comprehensive analysis of the causes of patients with hypokalemia should be considered and then the symptomatic treatment could be carried out.

  11. Complete genome sequence of Lactobacillus plantarum LZ206, a potential probiotic strain with antimicrobial activity against food-borne pathogenic microorganisms.

    Science.gov (United States)

    Li, Ping; Gu, Qing; Zhou, Qingqing

    2016-11-20

    Lactobacilli strains have been considered as important candidates for manufacturing "natural food", due to their antimicrobial properties and generally regarded as safe (GRAS) status. Lactobacillus plantarum LZ206 is a potential probiotic strain isolated from raw cow milk, with antimicrobial activity against various pathogens, including Gram-positive bacteria (Staphylococcus aureus and Listeria monocytogenes), Gram-negtive bacteria (Escherichia coli and Salmonella enterica), and fungus Candida albicans. To better understand molecular base for its antimicrobial activity, entire genome of LZ206 was sequenced. It was revealed that genome of LZ206 contained a circular 3,212,951-bp chromosome, two circular plasmids and one predicted linear plasmid. A plantaricin gene cluster, which is responsible for bacteriocins biosynthesis and could be associated with its broad-spectrum antimicrobial activity, was identified based on comparative genomic analysis. Whole genome sequencing of L. plantarum LZ206 might facilitate its applications to protect food products from pathogens' contamination in the dairy industry.

  12. 18 CFR Appendix I to Subpart F of... - Procedures for Compliance With the Endangered Species Act of 1973 Under § 157.206(b)(3)(i)

    Science.gov (United States)

    2010-04-01

    ... Compliance With the Endangered Species Act of 1973 Under § 157.206(b)(3)(i) I Appendix I to Subpart F of... Transactions and Abandonment Pt. 157, Subpt. F, App. I Appendix I to Subpart F of Part 157—Procedures for Compliance With the Endangered Species Act of 1973 Under § 157.206(b)(3)(i) The following procedures apply...

  13. 氯胺酮对抑郁大鼠海马微小RNA206表达的影响%Effect of ketamine on expression of hippocampal microRNA-206 in mentally depressed rats

    Institute of Scientific and Technical Information of China (English)

    杨晓玲; 周敏; 王晓斌; 王姬; 万运强; 张春祥

    2016-01-01

    目的 评价氯胺酮对抑郁大鼠海马微小RNA 206(miR-206)表达的影响.方法 清洁级健康雌性SD大鼠80只,体重200~300 g,2~3月龄,采用随机数字表法,将其分为4组(n=20):正常对照组(C组)、氯胺酮组(K组)、抑郁组(D组)和抑郁+氯胺酮组(D+K组).采用慢性不可预见轻度应激法制备大鼠抑郁模型.于模型制备成功后1d时,K组和D+K组腹腔注射氯胺酮15 mg/kg,其它2组给予等容量生理盐水.每组取10只大鼠,于模型制备前、模型制备7、14、21、28、35 d、给药后1、3、5和7d时行糖水偏好实验,于给药后1d时行旷场实验,于给药后2d时行强迫游泳实验.每组于给药后6h时取5只大鼠,采用实时定量PCR法检测海马miR-206表达;每组于给药后2d时取5只大鼠,采用Western blot法检测海马脑源性神经营养因子(BDNF)表达.结果 与C组比较,D组模型制备21~35 d、给药后各时点蔗糖摄入量和旷场实验评分降低,强迫游泳不动时间缩短,海马miR-206表达上调,海马BDNF表达下调,K组强迫游泳不动时间缩短,海马miR-206表达下调,海马BDNF表达上调,D+K组模型制备21~35 d时蔗糖摄入量和旷场实验评分降低(P<0.05);与D组比较,D+K组给药后各时点蔗糖摄入量升高,强迫游泳不动时间缩短,海马miR-206表达下调,海马BDNF表达上调(P<0.05).结论 氯胺酮对大鼠发挥抗抑郁作用的机制与下调海马miR-206表达,上调海马BDNF表达有关.%Objective To evaluate the effect of ketamine on the expression of hippocampal microRNA-206 (miR-206) in the mentally depressed rats.Methods Eighty healthy female Sprague-Dawley rats,weighing 200-300 g,aged 2-3 months,were randomly divided into 4 groups (n=20 each) using a random number table:normal control group (C group),ketamine group (K group),depression group (D group) and depression + ketamine group (D+K group).Mental depression was induced by exposing the animal to chronic unpredictable mild stress.At 1

  14. The role of Ethics in the process of Technology Transfer and Development of 206 Peugeot

    Directory of Open Access Journals (Sweden)

    Aliakbar Mazlomi

    2011-02-01

    Full Text Available Looking at the past history we find that the first phenomenon of technology transfer was taught by people who were traveling to another community and bring their technology, they move. After theindustrialization, transfer of knowledge from individuals to maintain their importance. However, now the situation for developing countries is controversial because it denied people with technical skills fromdeveloped countries to developing countries do not migrate, but the reverse is the professionals that are developing countries to developed countries loan go. Until developing countries can train your human resources specialist, they powerful companies overseas are the means of technology transfer, whether through direct investment, and whether through the sale of licenses and other means. (Noble, p. 105 - 106, 1367 Technology transfer is an important issue that should be given the capacity of countries to assess the possibility of application, absorption and its compatibility with local conditions to increase. Ie the transfer of technology and gain access to technology for its effective use for economic development and growth of countries relatively backward technology provides. (Archibugi, 2003 Today, the role of ethics in technology transfer and development is of great importance. The meaning of ethics and technology than are harvested, ethical values that have roles in the formation of modern technology. Another meaning of ethics and technology than is reached, that moral people who are dealing with technology, they must observe. It also includes technology to those that exist and sets it to those who apply and who are the analysis and criticism. In this article factors and ethical factors in the process of technology transfer and development for Peugeot 206 in Iran Khodro Company has been studied. For this purpose a questionnaire to determine and evaluate factors is designed and results are analyzed.

  15. Isolation and identification of 206 strains of candida and analysis of their drug resistance%临床分离206株念珠菌的培养鉴定及其耐药性分析

    Institute of Scientific and Technical Information of China (English)

    王业芳

    2011-01-01

    Objective To isolate and identify 206 strains of candida,and to test their microbial sensitivity in order to guide rational clinical administration. Methods Samples including sputum, urine, blood and other secretion sent for detection from Jan. to Dec. 2010, were cultured and isolated by routine methods, and identified with France Biomerieux ATB express system. A drug sensitivity test was done by ATB fungus strip. Results Among the 206 strains of candida,Candida albicans was the most frequently species(41.75%),followed by C. tropicalis(24.76%),C, parapsilosis(14.08%),C, krusei(9.71%),C, glabrata(7.28%) and others (2.43%). All the 206 strains of candida were sensitive to amphotericin B and did not express resistance, most of them were sensirive to 5 fluorocytosine and nystatinum,and the resistance rates were lower. The resistance rates of most of them to ketoconnazole,econazole,miconazole were higher and cross resistance appeared. Conclusion Fungi are required to be sent for classification and drug resistance study so as to rationally use anti fungal agent to reduce the development of drug resistant strains.%目的 对引起感染的206株临床分离的念珠菌进行分离鉴定和药敏试验,了解念珠菌耐药现状,以指导临床合理用药.方法 收集2010年1~12月临床送检的痰液、尿液、血液及各种分泌物等标本,采用常规方法培养和分离念珠菌,用法国生物梅里埃ATB express系统对念珠菌进行鉴定,用ATB fungus药敏试条进行药敏试验.结果 206株念珠菌中,白色念珠菌占41.75%、热带念珠菌占24.76%、近平滑念珠菌占14.08%、克柔念珠菌占9.71%、光滑念珠菌占7.28%、其他念珠菌占2.43%.206株念珠菌对两性霉素B敏感,未出现抗药性;绝大多数菌株对5-氟胞嘧啶、制霉菌素敏感,耐药率较低;对3种咪唑类药物(酮康唑、益康唑、咪康唑)耐药率较高且出现交叉耐药.结论 临床需要加强真菌送检培养,合理使用

  16. Realization of Interface of 1-Wire Bus Temperature-Transducer Using TMS320F206's ASP%用TMS320F206的ASP实现1-Wire总线温度传感器接口

    Institute of Scientific and Technical Information of China (English)

    袁华; 陈仁文

    2004-01-01

    1-Wire总线是低速总线,存在长时间的延时.为了提高DSP使用效率,利用TMS320F206的片内ASP(异步串行口),采用UART(通用异步收发)方式,模拟1-Wire总线时序,实现与1-Wire总线数字温度传感器DS18B20的通信.提供了方便、高效的低速总线与高速处理器的接口.

  17. 未足月临界羊水过少206例临床分析%The clinical analysis of 206 cases for preterm and borderline oligohy dramnios

    Institute of Scientific and Technical Information of China (English)

    张东梅

    2013-01-01

      目的:探讨未足月羊水临界过少治疗效果及对分娩结局的影响。方法:回顾性分析门诊立卡定期产检,妊娠32周后但未足37周发现羊水过少并治疗及分娩的孕妇206例为研究组,同期产检未发生羊水过少206例作为对照组,比较两组孕产妇的胎位异常、胎儿窘迫、羊水Ⅲ度混、自然分娩、急诊剖宫产、早产、新生儿窒息等方面的差异。结果:研究组经过输液治疗能有效改善胎盘血液循环,增加胎儿肾脏血流量,从而增加羊水量、降低剖宫产率及新生儿窒息率。结论:孕晚期临界羊水过少经过积极治疗,适时终止妊娠,能有效改善妊娠结局。%Objective To investigate the therapeutic effect of amniotic fluid too little preterm and critical impact on delivery outcome. Methods A retrospective analysis of clinic filed regular check-ups,after 32 weeks of pregnancy but not enough 37 weeks found that maternal oligohydramnios and treatment and delivery for 206 cases of the study group,at the same time production without oligohydramnios 206 cases as the control group,the difference between the two groups of maternal fetal abnormalities,fetal distress,amniotic fluid of mixing,natural childbirth,emergency cesarean section,premature delivery,neonatal asphyxia,etc.Results The study group after infusion therapy can effectively improve the placenta blood circulation,increase of fetal renal blood flow,thereby increasing the volume of amniotic fluid,reduce the rate of cesarean section and neonatal asphyxia rate.Conclusion Critical oligohydramnios in late pregnancy after active treatment,timely termination of pregnancy,can effectively improve the outcome of pregnancy.

  18. MicroRNA-206 is highly expressed in newly formed muscle fibers: implications regarding potential for muscle regeneration and maturation in muscular dystrophy.

    Science.gov (United States)

    Yuasa, Katsutoshi; Hagiwara, Yasuko; Ando, Masanori; Nakamura, Akinori; Takeda, Shin'ichi; Hijikata, Takao

    2008-01-01

    miR-1, miR-133a, and miR-206 are muscle-specific microRNAs expressed in skeletal muscles and have been shown to contribute to muscle development. To gain insight into the pathophysiological roles of these three microRNAs in dystrophin-deficient muscular dystrophy, their expression in the tibialis anterior (TA) muscles of mdx mice and CXMD(J) dogs were evaluated by semiquantitative RT-PCR and in situ hybridization. Their temporal and spatial expression patterns were also analyzed in C2C12 cells during muscle differentiation and in cardiotoxin (CTX)-injured TA muscles to examine how muscle degeneration and regeneration affect their expression. In dystrophic TA muscles of mdx mice, miR-206 expression was significantly elevated as compared to that in control TA muscles of age-matched B10 mice, whereas there were no differences in miR-1 or miR-133a expression between B10 and mdx TA muscles. On in situ hybridization analysis, intense signals for miR-206 probes were localized in newly formed myotubes with centralized nuclei, or regenerating muscle fibers, but not in intact pre-degenerated fibers or numerous small mononucleated cells, possibly proliferating myoblasts and inflammatory infiltrates. Similar increased expression of miR-206 was also found in C2C12 differentiation and CTX-induced regeneration, in which differentiated myotubes or regenerating fibers showed abundant expression of miR-206. However, CXMD(J) TA muscles contained smaller amounts of miR-206, miR-1, and miR-133a than controls. They exhibited more severe and more progressive degenerative alterations than mdx TA muscles. Taken together, these observations indicated that newly formed myotubes showed markedly increased expression of miR-206, which might reflect active regeneration and efficient maturation of skeletal muscle fibers.

  19. Ada (trade name) Compiler Validation Summary Report: Rational Environment, Version A.2.0.6 for Rational R1000.

    Science.gov (United States)

    2014-09-26

    RD-Ali57 830 ADA (TRADE NAME) COMPILER VALIDATION SUMMARY REPORT: 1/ RATIONAL ENVIRONMENT VERSION R296 FOR RATIONAL Ri888 (U) SOFTECH INC FAIRBORN OH...USoCPY WSSOS.UTM iTS GWAT % : 4 AVF Control Number: AVF-VSR-09.0585 0 IAda Compiler Validation Summary Report: Rational Environment Version A.2.0.6 For...77. . 77-4- .- REPORT DOCUMENTATION PAGERED1S1IT0$ L~~~~ 1YP 0061 1tO REPORT 6 PL eDD COVERED Ada* Compiler Validation Summary Report: Rational May

  20. 206Pb-230Th-234U-238U and 207Pb-235U geochronology of Quaternary opal, Yucca Mountain, Nevada

    Science.gov (United States)

    Neymark, Leonid A.; Amelin, Yuri V.; Paces, James B.

    2000-01-01

    U–Th–Pb isotopic systems have been studied in submillimeter-thick outermost layers of Quaternary opal occurring in calcite–silica fracture and cavity coatings within Tertiary tuffs at Yucca Mountain, Nevada, USA. These coatings preserve a record of paleohydrologic conditions at this site, which is being evaluated as a potential high-level nuclear waste repository. The opal precipitated from groundwater is variably enriched in 234U (measured 234U/238U activity ratio 1.124–6.179) and has high U (30–313 ppm), low Th (0.008–3.7 ppm), and low common Pb concentrations (measured 206Pb/204Pb up to 11,370). It has been demonstrated that the laboratory acid treatment used in this study to clean sample surfaces and to remove adherent calcite, did not disturb U–Th–Pb isotopic systems in opal. The opal ages calculated from 206Pb∗/238U and 207Pb∗/235U ratios display strong reverse discordance because of excess radiogenic 206Pb∗ derived from the elevated initial 234U. The data are best interpreted using projections of a new four-dimensional concordia diagram defined by 206Pb∗/238U, 207Pb∗/235U, 234U/238Uactivity, and 230Th/238Uactivity. Ages and initial 234U/238U activity ratios have been calculated using different projections of this diagram and tested for concordance. The data are discordant, that is observed 207Pb∗/235U ages of 170 ± 32 (2σ) to 1772 ± 40 ka are systematically older than 230Th/U ages of 34.1 ± 0.6 to 452 ± 32 ka. The age discordance is not a result of migration of uranium and its decay products under the open system conditions, but a consequence of noninstantaneous growth of opal. Combined U–Pb and 230Th/U ages support the model of slow mineral deposition at the rates of millimeters per million years resulting in layering on a scale too fine for mechanical sampling. In this case, U–Pb ages provide more accurate estimates of the average age for mixed multiage samples than 230Th/U ages, because ages based on shorter

  1. Higgs Candidates in $e^{+}e^{-}$ Interactions at $\\sqrt{s}$ = 206.6 GeV

    CERN Document Server

    Acciarri, M.; Adriani, O.; Aguilar-Benitez, M.; Alcaraz, J.; Alemanni, G.; Allaby, J.; Aloisio, A.; Alviggi, M.G.; Ambrosi, G.; Anderhub, H.; Andreev, Valery P.; Angelescu, T.; Anselmo, F.; Arefev, A.; Azemoon, T.; Aziz, T.; Bagnaia, P.; Bajo, A.; Baksay, L.; Balandras, A.; Baldew, S.V.; Banerjee, S.; Banerjee, Sw.; Barczyk, A.; Barillere, R.; Bartalini, P.; Basile, M.; Batalova, N.; Battiston, R.; Bay, A.; Becattini, F.; Becker, U.; Behner, F.; Bellucci, L.; Berbeco, R.; Berdugo, J.; Berges, P.; Bertucci, B.; Betev, B.L.; Bhattacharya, S.; Biasini, M.; Biland, A.; Blaising, J.J.; Blyth, S.C.; Bobbink, G.J.; Bohm, A.; Boldizsar, L.; Borgia, B.; Bourilkov, D.; Bourquin, M.; Braccini, S.; Branson, J.G.; Brochu, F.; Buffini, A.; Buijs, A.; Burger, J.D.; Burger, W.J.; Cai, X.D.; Capell, M.; Cara Romeo, G.; Carlino, G.; Cartacci, A.M.; Casaus, J.; Castellini, G.; Cavallari, F.; Cavallo, N.; Cecchi, C.; Cerrada, M.; Cesaroni, F.; Chamizo, M.; Chang, Y.H.; Chaturvedi, U.K.; Chemarin, M.; Chen, A.; Chen, G.; Chen, G.M.; Chen, H.F.; Chen, H.S.; Chiefari, G.; Cifarelli, L.; Cindolo, F.; Civinini, C.; Clare, I.; Clare, R.; Coignet, G.; Colino, N.; Costantini, S.; Cotorobai, F.; de la Cruz, B.; Csilling, A.; Cucciarelli, S.; Dai, T.S.; van Dalen, J.A.; D'Alessandro, R.; de Asmundis, R.; Deglon, P.; Degre, A.; Deiters, K.; della Volpe, D.; Delmeire, E.; Denes, P.; DeNotaristefani, F.; De Salvo, A.; Diemoz, M.; Dierckxsens, M.; van Dierendonck, D.; Dionisi, C.; Dittmar, M.; Dominguez, A.; Doria, A.; Dova, M.T.; Duchesneau, D.; Dufournaud, D.; Duinker, P.; Duran, I.; El Mamouni, H.; Engler, A.; Eppling, F.J.; Erne, F.C.; Ewers, A.; Extermann, P.; Fabre, M.; Falagan, M.A.; Falciano, S.; Favara, A.; Fay, J.; Fedin, O.; Felcini, M.; Ferguson, T.; Fesefeldt, H.; Fiandrini, E.; Field, J.H.; Filthaut, F.; Fisher, P.H.; Fisk, I.; Forconi, G.; Freudenreich, K.; Furetta, C.; Galaktionov, Iouri; Ganguli, S.N.; Garcia-Abia, Pablo; Gataullin, M.; Gau, S.S.; Gentile, S.; Gheordanescu, N.; Giagu, S.; Gong, Z.F.; Grenier, Gerald Jean; Grimm, O.; Gruenewald, M.W.; Guida, M.; van Gulik, R.; Gupta, V.K.; Gurtu, A.; Gutay, L.J.; Haas, D.; Hasan, A.; Hatzifotiadou, D.; Hebbeker, T.; Herve, Alain; Hidas, P.; Hirschfelder, J.; Hofer, H.; Holzner, G.; Hoorani, H.; Hou, S.R.; Hu, Y.; Iashvili, I.; Jin, B.N.; Jones, Lawrence W.; de Jong, P.; Josa-Mutuberria, I.; Khan, R.A.; Kafer, D.; Kaur, M.; Kienzle-Focacci, M.N.; Kim, D.; Kim, J.K.; Kirkby, Jasper; Kiss, D.; Kittel, W.; Klimentov, A.; Konig, A.C.; Kopal, M.; Kopp, A.; Koutsenko, V.; Kraber, M.; Kraemer, R.W.; Krenz, W.; Kruger, A.; Kunin, A.; Ladron de Guevara, P.; Laktineh, I.; Landi, G.; Lebeau, M.; Lebedev, A.; Lebrun, P.; Lecomte, P.; Lecoq, P.; Le Coultre, P.; Lee, H.J.; Le Goff, J.M.; Leiste, R.; Levtchenko, P.; Li, C.; Likhoded, S.; Lin, C.H.; Lin, W.T.; Linde, F.L.; Lista, L.; Liu, Z.A.; Lohmann, W.; Longo, E.; Lu, Y.S.; Lubelsmeyer, K.; Luci, C.; Luckey, David; Lugnier, L.; Luminari, L.; Lustermann, W.; Ma, W.G.; Maity, M.; Malgeri, L.; Malinin, A.; Mana, C.; Mangeol, D.; Mans, J.; Marian, G.; Martin, J.P.; Marzano, F.; Mazumdar, K.; McNeil, R.R.; Mele, S.; Merola, L.; Meschini, M.; Metzger, W.J.; von der Mey, M.; Mihul, A.; Milcent, H.; Mirabelli, G.; Mnich, J.; Mohanty, G.B.; Moulik, T.; Muanza, G.S.; Muijs, A.J.M.; Musicar, B.; Musy, M.; Napolitano, M.; Nessi-Tedaldi, F.; Newman, H.; Niessen, T.; Nisati, A.; Kluge, Hannelies; Ofierzynski, R.; Organtini, G.; Oulianov, A.; Palomares, C.; Pandoulas, D.; Paoletti, S.; Paolucci, P.; Paramatti, R.; Park, H.K.; Park, I.H.; Passaleva, G.; Patricelli, S.; Paul, Thomas Cantzon; Pauluzzi, M.; Paus, C.; Pauss, F.; Pedace, M.; Pensotti, S.; Perret-Gallix, D.; Petersen, B.; Piccolo, D.; Pierella, F.; Pieri, M.; Piroue, P.A.; Pistolesi, E.; Plyaskin, V.; Pohl, M.; Pojidaev, V.; Postema, H.; Pothier, J.; Prokofev, D.O.; Prokofev, D.; Quartieri, J.; Rahal-Callot, G.; Rahaman, M.A.; Raics, P.; Raja, N.; Ramelli, R.; Rancoita, P.G.; Ranieri, R.; Raspereza, A.; Raven, G.; Razis, P.; Ren, D.; Rescigno, M.; Reucroft, S.; Riemann, S.; Riles, Keith; Rodin, J.; Roe, B.P.; Romero, L.; Rosca, A.; Rosier-Lees, S.; Roth, Stefan; Rosenbleck, C.; Rubio, J.A.; Ruggiero, G.; Rykaczewski, H.; Saremi, S.; Sarkar, S.; Salicio, J.; Sanchez, E.; Sanders, M.P.; Schafer, C.; Schegelsky, V.; Schmidt-Kaerst, S.; Schmitz, D.; Schopper, H.; Schotanus, D.J.; Schwering, G.; Sciacca, C.; Seganti, A.; Servoli, L.; Shevchenko, S.; Shivarov, N.; Shoutko, V.; Shumilov, E.; Shvorob, A.; Siedenburg, T.; Son, D.; Smith, B.; Spillantini, P.; Steuer, M.; Stickland, D.P.; Stone, A.; Stoyanov, B.; Straessner, A.; Sudhakar, K.; Sultanov, G.; Sun, L.Z.; Sushkov, S.; Suter, H.; Swain, J.D.; Szillasi, Z.; Sztaricskai, T.; Tang, X.W.; Tauscher, L.; Taylor, L.; Tellili, B.; Timmermans, Charles

    2000-01-01

    In a search for the Standard Model Higgs boson, carried out on 212.5 pb-1 of data collected by the L3 detector at the highest LEP centre-of-mass energies, including 116.5 pb-1 above root(s) = 206GeV, an excess of candidates for the process e+e- -> Z* -> HZ is found for Higgs masses near 114.5GeV. We present an analysis of our data and the characteristics of our strongest candidates.

  2. Caracterización de tres nuevas variedades de vignas (‘IPA 206’ e ‘IPA 207’ y ‘Guariba’ en Cuba.

    Directory of Open Access Journals (Sweden)

    Yadelys Figueroa Aguila

    2012-07-01

    Full Text Available RESUMEN La investigación se desarrolló sobre un suelo Pardo mullido medianamente lavado con las variedades de vignas (‘IPA 206’, ‘IPA 207’ y ‘Guariba’ de reciente introducción en nuestro país. Tiene como principal objetivo caracterizar las variedades (‘IPA 206, ‘IPA 207’ y ‘Guariba’ bajo nuestras condiciones climáticas. Teniendo como principales resultados que se logró incluir en el registro de variedades según la caracterización desarrollada por nuestro instituto utilizando dos épocas de siembra, el hábitos de crecimiento indeterminado con vainas distribuidas por toda la planta se destaca en las variedades ‘IPA 206’ e ‘IPA 207’, mientras que en la ‘Guariba’ es determinado encontrándose estas distribuidas por encima de la planta, en cuanto al rendimiento, la variedad ‘IPA 207’ es superiores que la obtenida por la ‘'PA 206’ y ‘Guariba’, el peso de 1000 semillas en las variedades ‘Guariba’ y ‘IPA 206’ son superiores al peso de la ‘IPA 207’, la variedad ‘Guariba’ es económicamente más rentable que las ‘IPA 206’ y ‘IPA 207’ por emplear un número de cosechas muy inferior a las antes mencionadas. Puede sembrarse durante todas las épocas del año, pero lo más aconsejable es en época de frío para la obtención de semilla y el verano para la producción donde es más productiva y puede sustituir al fríjol común. Tolera estrés hídrico y régimen de abundantes lluvias, excepto en el momento de la cosecha y no admite el encharcamiento. Characterization of three new varieties vignas (' IPA 206' and ' IPA 207' y 'Guariba' in Cuba. ABSTRACT The research was conducted on a fairly soft Brown soil washing vignas varieties ('IPA 206', 'IPA 207' and 'Guariba' recently introduced in our country. Its main objective is to characterize varieties ('IPA 206,' IPA 207 'and' Guariba ' under our climatic conditions. Having as main results achieved include in the record as the

  3. 泡盛曲霉FCYN206对EM菌青贮香蕉茎叶中单宁的影响

    Institute of Scientific and Technical Information of China (English)

    王少曼; 陈百莹; 李红歌; 游向荣; 孙健; 万茵; 刘成梅; 付桂明

    2016-01-01

    为了高效降解青贮香蕉茎叶中的单宁,本试验研究添加产单宁酶菌株———泡盛曲霉FCYN206对香蕉茎叶青贮品质的影响。试验设计对照组、泡盛曲霉FCYN206菌组、EM菌组和EM菌+泡盛曲霉FCYN206菌组,青贮20 d,开封测定青贮品质。结果表明:与对照组比,菌株泡盛曲霉FCYN206可减少干物质损失,显著降低单宁含量(P<0.05),但对饲料粗蛋白质含量无明显作用;EM菌能提高饲料粗蛋白质含量,但对单宁降解无效果;EM菌+泡盛曲霉FCYN206组pH为3.91,达到青贮标准,感官评价最好,且与对照组相比,单宁含量显著降低4.49%(P<0.05)。添加泡盛曲霉FCYN206对EM菌青贮香蕉茎叶中的单宁有明显降解作用,能改善青贮香蕉茎叶饲料的感官品质和风味。%To effectively degrade the tannin content in banana stem and leaf silage,this experiment was conducted to investigate the effect of Aspergillus awamori FCYN206 on fermentation quality and chemical composition of banana stem and leaf silage.Three fermentation groups were designed:A.awamori FCYN206 group,EM (Effective Microorganisms,EM) strain group,EM strain+A.awamori FCYN206 group.The silage quality of them were statistically analyzed after 20 days.The results showed as follow:compared with the control group(without additive),dry matter content of silage was improved and tannin content of silage was obviously reduced after adding A.awamori FCYN206 (A.awamori FCYN206 group),but it had no obvious effect on crude protein content of silage.After adding EM strain (EM strain group),crude protein content of silage was improved.However,it had no effect on the degradation of tannin.The pH value of silage was 3.91,which reached to the standard of good or best silage after adding EM strain and A.awamori FCYN206 group.Notably,tannin of silage was obviously reduced after adding them.So adding A.awamori FCYN206 could effectively degrade the tannin content

  4. Treating 206 cases of amenorrhea galactorrhea syndrome infertility in the integrative medicine%中西医结合治疗闭经溢乳综合征之不孕206

    Institute of Scientific and Technical Information of China (English)

    张华

    2013-01-01

    Objective: To investigate amenorrhea galactorrhea syndrome caused infertility in the integrative medicine treatment. Methods:Clinical admitted due to amenorrhea galactorrhea syndrome caused infertility patients in modern medicine treatment of 206 cases and analyze. Results: The cure rate and total efficiency of the integrative treatment due to amenorrhea galactorrhea syndrome caused infertility patients than purely modern medicine treatment group. Conclusion: Integrative medicine amenorrhea galactorrhea syndrome infertility treatment is worth promoting.%  目的:探讨闭经溢乳综合征引起的不孕症的中西医综合治疗方法。方法:通过临床收治的因闭经溢乳综合征引起的不孕症患者206例的中西医综合治疗并进行分析总结。结果:中西医综合治疗因闭经溢乳综合征引起的不孕症患者的治愈率及总有效率均高于单纯西医治疗组。结论:中西医结合治疗闭经溢乳综合征不孕症是值得推广的治疗方法。

  5. Clinical Analysis of 206 Cases of Severe Preeclampsia Terminate the Pregnancy Timing and the Way%206例重度子痫前期终止妊娠时机和方式的临床分析

    Institute of Scientific and Technical Information of China (English)

    赵玉仙

    2012-01-01

      Objective To explore the time and method of pregnancy termination of early onset severe preeclampsia, and the influence on newborns, to research the clinical definition of early onset severe preeclampsia and the meaning of expectant management. Methods A retrospective study was carried out on 206 patients with severe preeclampsia, all the patients were divided into three groups according to week of gestation:Ⅰ(≥34 wks);Ⅱ(32~34 wks);Ⅲ(≤32 wks), observed the effect of gestational age on neonatal survival and the damage of complications to maternal during expectant management. Results 206 patients were all survived , there was no significant differences in the method of delivery ,neonatal asphyxia and death rate(P>0.05); neonatal asphyxia and mortality in groupⅢwas highly significant than groupⅠandⅡ(P0.05).Conclusion Patients with severe preeclampsia should be timely terminated ,termination of pregnancy is one of the most important factors to effect neonatal outcomes , it is much more accurately to defined 32 weeks as the severe preeclampsia which can reflect the relationship between pregnancy termination and the outcomes of neonatal.%  目的探讨重度子痫前期终止妊娠的时机和方式,以及对新生儿的影响,并进一步研究早发型重度子痫前期的临床界定及期待治疗的意义.方法通过对206例重度子痫前期进行回顾性分析,根据入院孕周分为三组:I组≥34周,Ⅱ组≥32周0.05),新生儿窒息率与病死率Ⅲ组明显高于I和Ⅱ组,但Ⅱ组和I组间无显著差异(P>0.05).结论重度子痫前期患者应适时终止妊娠,终止妊娠孕周是影响围生儿结局的重要因素,临床上以32周界定早发型重度子痫前期更能准确反应终止孕周与新生儿结局的关系.

  6. Effects of miR-206/miR-1 on Breast Cancer Stem Cell Proliferation and the Mechanism%miR-206/miR-1对乳腺癌干细胞增殖的影响及作用机制

    Institute of Scientific and Technical Information of China (English)

    孟琳; 王天一; 李晓曦; 马萍

    2015-01-01

    Objective To investigate the effects of up⁃regulated miR⁃206/miR⁃1 on the proliferation of breast cancer stem cells and the effect mech⁃anism. Methods Breast cancer stem cells(BCSCs)were isolated from breast cancer cell line MCF⁃7 by fluorescence⁃activated cell sorting. Cells in the experiment were divided into the blank control group,the negative control group,the miR⁃206 group and the miR⁃1 group. The BCSCs were transfected by negative control mimic,hsa⁃miR⁃206mimic and hsa⁃miR⁃1mimic in all groups except the blank control group. MiR⁃206and miR⁃1 expression levels as well as the transcription factor EVI⁃1 gene were detected by real time PCR. The expression levels of the transcription factor EVI⁃1 protein were detected by Western blot. MTT method was used to detect the effects of miR⁃206 and miR⁃1 on the proliferation of BCSCs. Results The BCSCs(CD44+/CD24-/low cells)isolated from MCF⁃7 cell lines were successfully cultured in serum⁃free medium for subsequent studies. After transfection of hsa⁃miR⁃206mimic and hsa⁃miR⁃1mimic for 48 hours,miR⁃206and miR⁃1relative expression levels increased. EVI⁃1mRNA ex⁃pression levels significantly decreased. The results of Western blot and MTT showed that up⁃regulated expression levels of miR⁃206 and miR⁃1 could significantly reduce the expression of EVI⁃1 protein and inhibited the proliferation of BCSCs. The differences in levels of miR⁃206,miR⁃1 and EVI⁃1 protein were statistically significant(P<0.05). Conclusion Up⁃regulated miR⁃206 and miR⁃1 expression can inhibit the proliferation ability of BCSCs,which may be related to the down⁃regulation of EVI⁃1.%目的:探讨上调microRNA⁃206(miR⁃206)和microRNA⁃1(miR⁃1)表达对乳腺癌干细胞增殖的影响以及其作用机制。方法采用流式细胞分选技术从乳腺癌细胞株MCF⁃7中分离出乳腺癌干细胞。实验分为空白对照组、阴性对照组、miR⁃206

  7. Roles of the canonical myomiRs mi R-1,-133 and-206 in cell development and disease

    Institute of Scientific and Technical Information of China (English)

    Keith; Richard; Mitchelson; Wen-Yan; Qin

    2015-01-01

    Micro RNAs are small non-coding RNAs that participate in different biological processes, providing subtle combinational regulation of cellular pathways, often by regulating components of signalling pathways. Aberrant expression of mi RNAs is an important factor in the development and progression of disease. The canonical myomi Rs(mi R-1,-133 and-206) are central to the development and health of mammalian skeletal and cardiac muscles, but new findings show they have regulatory roles in the development of other mammalian non-muscle tissues, including nerve, brain structures, adipose and some specialised immunological cells. Moreover, the deregulation of myomi R expression is associated with a variety of different cancers, where typically they have tumor suppressor functions, although examples of an oncogenic role illustrate their diverse function in different cell environments. This review examines the involvement of the related myomi Rs at the crossroads between cell development/tissue regeneration/tissue inflammation responses, and cancer development.

  8. The non-evolving internal structure of early-type galaxies: the case study SDSSJ0728+3835 at z = 0.206

    NARCIS (Netherlands)

    Barnabè, Matteo; Auger, Matthew W.; Treu, Tommaso; Koopmans, Léon V. E.; Bolton, Adam S.; Czoske, Oliver; Gavazzi, Raphaël

    2010-01-01

    We study the internal dynamical structure of the early-type lens galaxy SDSSJ0728+3835 at z = 0.206. The analysis is based on two-dimensional kinematic maps extending out to 1.7 effective radii obtained from Keck spectroscopy, on lensing geometry and on stellar mass estimates obtained from multiband

  9. The non-evolving internal structure of early-type galaxies : The case study SDSS J0728+3835 at z=0.206

    NARCIS (Netherlands)

    Barnabe, Matteo; Auger, Matthew W.; Treu, Tommaso; Koopmans, Leon V. E.; Bolton, Adam S.; Czoske, Oliver; Gavazzi, Raphael

    2010-01-01

    We study the internal dynamical structure of the early-type lens galaxy SDSS J0728+3835 at z = 0.206. The analysis is based on two-dimensional kinematic maps extending out to 1.7 effective radii obtained from Keck spectroscopy, on lensing geometry and on stellar mass estimates obtained from multiban

  10. 20 CFR 30.206 - How does a claimant prove that the employee was a “covered beryllium employee” exposed to...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How does a claimant prove that the employee was a âcovered beryllium employeeâ exposed to beryllium dust, particles or vapor in the performance of....206 How does a claimant prove that the employee was a “covered beryllium employee” exposed...

  11. 12 CFR 347.206 - Domestic retail deposit activity requiring deposit insurance by U.S. branch of a foreign bank.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Domestic retail deposit activity requiring... Banks § 347.206 Domestic retail deposit activity requiring deposit insurance by U.S. branch of a foreign bank. (a) Domestic retail deposit activity. To initiate or conduct domestic retail deposit...

  12. Isolation of Actinium from Neutron-irradiated Thorium-I

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Isolation of Actinium from Neutron-irradiated Thorium-I¥YangWeifan;YuanShuanggui;MuWantong;ZhangXueqian;LiZhongweiandZhaoLili...

  13. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  14. Analysis of prenatal diagnosis results of 206 thalassemia families%206例地中海贫血家系产前基因诊断结果分析

    Institute of Scientific and Technical Information of China (English)

    李莉艳; 钟梅; 陈翠华; 宋兰林; 靳旺杰; 王志坚

    2012-01-01

    Objective To summarize the geographical distribution,phenotype and genotype data of 206 thalassemia families underwent prenatal diagnosis to provide information for clinical genetic counseling and avoid the birth of severe thalassemia children. Methods Totally,206 thalassemia families were collected from Southern Medical University Nanfang Hospital from January 2008 to December 2009.Genomic DNA was extracted from peripheral blood,villus,amniotic fluid or cord blood from the couples or the fetuses.Gap-polymerase chain reaction (gap-PCR) and reverse dot blot (RDB) technology were used to detect the common α and β-thalassemia mutations.DNA sequencing was used to detect the rare mutations.Follow-up visit were done half a year after the fetuses were born. Results The 206 thalassemia families came from 12 provinces and areas across China,including Heilongjiang province.Mutations detected in α-thalassemia families included --SEA/,-α3.7/,-α4.2/,αCS α/ and αQS α/,which were all included in the testing kit. While there were 4 kinds of β-thalassemia mutations,Gγ+ (A γδβ)0,-28(A→C),CD54-58(-TATGGGCAACCCT) and CD37(G→A),could not be identified with routine testing kit. The 57 α-thalassemia families consisted of 11(19.3%) severe thalassemia,induding 8 Bart's hydrops syndrome and 3 Hb H disease,26(45.6%) heterozygote and 20(35.1%) normal infants,and the 149 β-thalassemia majors families consisted of 28 (18.8%) severe thalassemia,82(55.0%) heterozygote and 39 (26.2%) normal infants.Among the β-thalassemia heterozygotes,there was one 13-trisomy.Follow-up visit found that babies with Bart ' s hydrops syndrome (n =8),Hb H disease (n =3),β-thalassemia majors (n =28) and β thalassemia heterozygote combined with 13-trisomy(n=1) were aborted. Conclusions Thalassemia was found in some north area other than south of China,which should be paid more attention by clinicians.Gap-PCR and PCR-RDB technology are effective measures for thalassemia prenatal

  15. Organic Geochemical Stratum Characteristics from Memberl of Qingshankou Formation in the Well Mao 206 of Songliao Basin%松辽盆地茂206井青山口组一段有机地球化学特征

    Institute of Scientific and Technical Information of China (English)

    韩刚; 王敬岩; 张文婧; 黄清华

    2011-01-01

    The Songliao Basin was a large lacustrine one during Late Cretaceous,where the dark mudsones,shales and oil-shales of Qingshankou Formation were distributed widely and oilshales were considered as the primary marker beds of division and correlation in the basin.The dark shales and mudstones in Qingshankou Formation from well Mao 206 were of high organic carbon and low diasteranes contents.Organic geochemical characters were illustrated by biomarkers of gammacerane and positive excursion of kerogen isotopes.It is suggested that the dark mudstones and shales in the Member 1 of Qingshankou Formation are the products of lake anoxic in the extreme greenhouse climate period.Angiosperm farina at the bottom of Qingshankou Formation has significant era significance , it also proves that the age of the bottom of Qingshankou Formation in Songliao Basin should be Turonian and be not Cenomanian.%松辽盆地白垩纪青山口组下部分布一套富含有机碳的黑色泥岩、页岩和油页岩沉积,是全盆地划分泉头组与青山口组的一级标志.茂206井青山口组黑色泥岩、页岩的地球化学特征研究表明:它具有相对高的有机碳、干酪根碳同位素正偏、重排甾烷含量低,普遍存在伽玛蜡烷生物标志化合物等有机地球化学特征,表征为白垩纪温室效应时间窗内古湖泊缺氧事件的产物.而青山口组底部出现的一些具重要时代意义的被子植物花粉,也证实了青山口组底界已属Turonian期,而非Ceno-.manian期.

  16. Analysis of temperament characteristics of 206 infants aged 5~ 11 months%5~11个月婴儿气质特点206例分析

    Institute of Scientific and Technical Information of China (English)

    张永明

    2012-01-01

    [Objective] To investigate temperament characteristics of infants and guide parents to rear the infants and develop a good emotional response. [Method] 206 infants were surveyed with Carey's Temperament Questionnaire Scale. [Results] The proportion of infants with different temperament types in this district was 36. 2% for easy type and 41. 4% intermediate low child type,8. 6% for difficult type and 6. 7% for intermediate high child type and 7. 1 % for slow-to-warm up type of temperament. There were significant the cesarean section group and the spontaneous delivery group in distribution of all temperament types(x2 = 10. 391 ,P = 0. 034). There were no significant differences in gender dimensions of infant tem-perament(all P>0. 05). There were no significant gender differences in distribution of all temperament types(x2 = 5. 002,P = 0. 287). [Conclusion] To carry out the work of early childhood development, more attention should be paied to earlychildhood temperament characteristics.%[目的]了解婴儿气质特征,指导家长科学养育,培养婴儿良好的情绪、情感反应. [方法]采用《Carey5~11月婴儿气质问卷》,对西城区社区保健科206名5~11月婴儿进行调查分析. [结果]婴儿的主要气质类型分别为:易养型(36.2%)、中间偏易养型(41.4%)、困难型(8.6%)、启动缓慢型(7.1%)、中间偏难养型(6.7%).剖宫产婴儿与自然分娩婴儿气质特点的比较,差异有统计学意义(x2=10.391,P=0.034);不同性别婴儿气质维度中,男童与女童无显著性差异(P均>0.05);不同气质类型分布之间性别比较差异无统计学意义(x2=5.002,P=0.287). [结论]开展儿童早期综合发展工作,应重视早期儿童的气质特点.

  17. An Activin Receptor IA/Activin-Like Kinase-2 (R206H Mutation in Fibrodysplasia Ossificans Progressiva

    Directory of Open Access Journals (Sweden)

    Rafael Herrera-Esparza

    2013-01-01

    Full Text Available Fibrodysplasia ossificans progressiva (FOP is an exceptionally rare genetic disease that is characterised by congenital malformations of the great toes and progressive heterotopic ossification (HO in specific anatomical areas. This disease is caused by a mutation in activin receptor IA/activin-like kinase-2 (ACVR1/ALK2. A Mexican family with one member affected by FOP was studied. The patient is a 19-year-old female who first presented with symptoms of FOP at 8 years old; she developed spontaneous and painful swelling of the right scapular area accompanied by functional limitation of movement. Mutation analysis was performed in which genomic DNA as PCR amplified using primers flanking exons 4 and 6, and PCR products were digested with Cac8I and HphI restriction enzymes. The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G>A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP signalling that causes FOP.

  18. Neutron particle-hole electric dipole states in /sup 206/ /sup 207/ /sup 208/Pb. [16. 2 to 17. 8 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Dickey, P.A.

    1979-01-01

    Inelastic proton scattering on /sup 206/Pb, /sup 207/Pb, and /sup 208/Pb through isobaric analog resonances was used to study neutron particle-hole excitations with large ground-state gamma branches in these Pb isotopes. Relative (p,p') cross sections at 90/sup 0/ are extracted for structures selectively excited on the d/sub 5/2/, s/sub 1/2/, and d/sub 3/2/-g/sub 7/2/ resonances. Interpretation of excitations in /sup 206/Pb and /sup 207/Pb in terms of coupling to states in /sup 208/Pb is discussed. Branching ratios for 1/sup -/ states in /sup 208/Pb at 4.84, 5.29, 5.94, and 6.31 MeV and the 1/2/sup +/ state in /sup 207/Pb at 4.63 MeV are deduced. 15 figures, 4 tables.

  19. 好玩掀背:长安福特FOCUS VS.欧宝ASTRA VS.东风标致206

    Institute of Scientific and Technical Information of China (English)

    AT.Test; Team; 阮锦程(图)

    2006-01-01

    欧洲车厂向来热衷炮制小巧灵活的掀背车,最近国内车厂似乎也掀起一股掀背热潮,206与FOCUS五门版先后上市,我们今次连同向来推崇的ASTRA,一起来个好玩掀背的联名推介。

  20. 粗山羊草抗条锈病新基因YrY206遗传分析和微卫星标记%Genetic Analysis and S S R Mapping on an New Stem Stripe Rust Resistance Gene YrY206 in Aegilops tauschii

    Institute of Scientific and Technical Information of China (English)

    张海泉; 郎杰; 马淑琴; 张宝石

    2008-01-01

    从小麦野生近缘属--粗山羊草中挖掘小麦条锈病抗病基因,拓展小麦抗病性的遗传基础.利用抗小麦条锈病与感小麦条锈病的粗山羊草间杂交,从粗山羊草[Aegilops tauschii(Coss.)Schmal]Y206中鉴定出1个显性抗小麦条锈病基因,暂定名为YrY206.应用分离群体分组法(Bulked segregantanalysis,BSA)筛选到Wmc11a、Xgwm71c、Xgwm161和Xgwm183标记,与该基因之间的遗传距离分别为4.0、3.3、1.5和9.3 cM.根据连锁标记所在小麦微卫星图谱的位置,YrY206被定位在3DS染色体上.分析基因所在染色体的位置、抗病性特征,认为YrY206是一个新的抗小麦条锈病基因.

  1. Chromosome studies of European cyprinid fishes: cross-species painting reveals natural allotetraploid origin of a Carassius female with 206 chromosomes.

    Science.gov (United States)

    Knytl, M; Kalous, L; Symonová, R; Rylková, K; Ráb, P

    2013-01-01

    A single female with 206 chromosomes and another 26 females with 156 chromosomes identified as Prussian carp, Carassius gibelio, and 5 individuals with 100 chromosomes identified as crucian carp, C. carassius, were sampled during field survey in one locality in the upper Elbe River. To identify the origin of females with high chromosome numbers, comparative karyotype analysis, GISH, with whole C. carassius DNA as probe and phylogenetic positions of sampled individuals revealed by cytochrome b mitochondrial marker were performed. GISH showed consistently bright labeling of 50 chromosomal elements out of 206, corresponding to the haploid chromosome number of C. carassius. The position of these females with high chromosome numbers in a reconstructed phylogenetic tree was within the clade of C. gibelio, documenting its affiliation to C. gibelio mitochondrial, i.e. maternal lineage. Our findings indicated that the mother of the female with high chromosome numbers was a gynogenetically reproducing 156-chromosome C. gibelio female and the father a bisexually reproducing C. carassius male. We, therefore, hypothesized that the C. gibelio × C. carassius allopolyploid female with 206 chromosomes arose by a mechanism of sperm genome addition to an unreduced egg of the mother.

  2. A comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana; Vasina, Libor; Bajgar, Jiri; Kuca, Kamil; Musilek, Kamil

    2009-01-01

    The neuroprotective effects of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with tabun at a sublethal dose (180 microg/kg i.m.; 80% LD(50)) were studied. The tabun-induced neurotoxicity was monitored by using a functional observational battery and an automatic measurement of motor activity. The neurotoxicity of tabun was monitored at 24 hours and 7 days following tabun challenge. The results indicate that K203 and obidoxime in combination with atropine allow all tabun-poisoned rats to survive within 7 days following tabun challenge, while 2 nontreated tabun-poisoned rats and 1 tabun-poisoned rat treated with K206 or HI-6 in combination with atropine died within 7 days. Only one of the newly developed oximes (K203) combined with atropine seems to be effective for a decrease in tabun-induced neurotoxicity within 24 hours after tabun sublethal poisoning, although it is not able to eliminate tabun-induced neurotoxicity completely. On the other hand, the neuroprotective efficacy of commonly used oximes (obidoxime and HI-6), as well as one of the new synthesized oximes (K206), is significantly lower in comparison with K203, according to the number of eliminated tabun-induced neurotoxic signs at 24 hours after tabun challenge. Due to its neuroprotective effects, K203 appears to be a suitable oxime for the antidotal treatment of acute tabun poisonings.

  3. Tree rings as Pb pollution archives? A comparison of 206Pb/207Pb isotope ratios in pine and other environmental media.

    Science.gov (United States)

    Bindler, Richard; Renberg, Ingemar; Klaminder, Jonatan; Emteryd, Ove

    2004-02-05

    Tree rings, if validated as an environmental archive for pollution, would provide a convenient, geographically widespread archive for studying the temporal and spatial distribution of atmospheric pollutants. We collected tree-ring records from Scots pine (Pinus sylvestris L.), ranging in age from 100 to 300 years and from one spruce (Picea abies), from sites in southern and northern Sweden and analyzed their stable lead isotopic composition (206Pb/207Pb). These results are compared to the Pb isotopic composition in soil profiles from each of the sites and temporal changes in the 206Pb/207Pb ratio in peat and lake sediment deposits in Sweden. The mineral soils at each site are characterized by high 206Pb/207Pb ratios (> 1.35), while the ratios in the mor layer are low (1.14-1.16) and characterized by atmospheric lead pollution. The 206Pb/207Pb ratios of the tree rings, typically approximately 1.18-1.20, indicate a significant (10-30%) contribution of Pb derived from the underlying mineral soil. While peat and lake sediment records show that the 206Pb/207Pb ratio of atmospheric deposition has varied over time, with a pronounced trough between approximately 1930 and 1990, the tree rings show no similar trend. Further comparison of published Pb isotope data from other tree-ring records with time series from peat bogs and herbarium samples also shows poor agreement, and indicates that tree rings always contain a mixture of pollution Pb and Pb from the underlying mineral soil. The majority of Pb in the wood is derived from atmospheric pollution either directly, through aerial interception, or indirectly, through uptake from the large pool of accumulated pollution Pb in the soil. Since the Pb isotope ratios of the wood indicate that some natural Pb is taken up into the tree, then it must also be concluded that some fraction of the pollution Pb in the wood is likewise taken up from the forest soil. Based on the Pb isotope analyses, we can only conclude that dendrochemical

  4. The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced Silencing Complex*♦

    Science.gov (United States)

    King, Isabelle N.; Yartseva, Valeria; Salas, Donaldo; Kumar, Abhishek; Heidersbach, Amy; Ando, D. Michael; Stallings, Nancy R.; Elliott, Jeffrey L.; Srivastava, Deepak; Ivey, Kathryn N.

    2014-01-01

    MicroRNA (miRNA) maturation is regulated by interaction of particular miRNA precursors with specific RNA-binding proteins. Following their biogenesis, mature miRNAs are incorporated into the RNA-induced silencing complex (RISC) where they interact with mRNAs to negatively regulate protein production. However, little is known about how mature miRNAs are regulated at the level of their activity. To address this, we screened for proteins differentially bound to the mature form of the miR-1 or miR-133 miRNA families. These muscle-enriched, co-transcribed miRNA pairs cooperate to suppress smooth muscle gene expression in the heart. However, they also have opposing roles, with the miR-1 family, composed of miR-1 and miR-206, promoting myogenic differentiation, whereas miR-133 maintains the progenitor state. Here, we describe a physical interaction between TDP-43, an RNA-binding protein that forms aggregates in the neuromuscular disease, amyotrophic lateral sclerosis, and the miR-1, but not miR-133, family. Deficiency of the TDP-43 Drosophila ortholog enhanced dmiR-1 activity in vivo. In mammalian cells, TDP-43 limited the activity of both miR-1 and miR-206, but not the miR-133 family, by disrupting their RISC association. Consistent with TDP-43 dampening miR-1/206 activity, protein levels of the miR-1/206 targets, IGF-1 and HDAC4, were elevated in TDP-43 transgenic mouse muscle. This occurred without corresponding Igf-1 or Hdac4 mRNA increases and despite higher miR-1 and miR-206 expression. Our findings reveal that TDP-43 negatively regulates the activity of the miR-1 family of miRNAs by limiting their bioavailability for RISC loading and suggest a processing-independent mechanism for differential regulation of miRNA activity. PMID:24719334

  5. Effects of silicon, copper and iron on static and dynamic properties of alloy 206 (aluminum-copper) in semi-solids produced by the SEED process

    Science.gov (United States)

    Lemieux, Alain

    The advantages of producing metal parts by rheocasting are generally recognised for common foundry alloys of Al-Si. However, other more performing alloys in terms of mechanical properties could have a great interest in specialized applications in the automotive industry, while remaining competitive in the forming. Indeed, the growing demand for more competitive products requires the development of new alloys better suited to semi-solid processes. Among others, Al-Cu alloys of the 2XX series are known for their superior mechanical strength. However, in the past, 2XX alloys were never candidates for pressure die casting. The main reason is their propensity to hot tearing. Semi-solid processes provide better conditions for molding with the rheological behavior of dough and molding temperatures lower reducing this type of defect. In the initial phase, this research has studied factors that reduce hot tearing susceptibility of castings produced by semi-solid SEED of alloy 206. Subsequently, a comparative study on the tensile properties and fatigue was performed on four variants of the alloy 206. The results of tensile strength and fatigue were compared with the specifications for applications in the automotive industry and also to other competing processes and alloys. During this study, several metallurgical aspects were analyzed. The following main points have been validated: i) the main effects of compositional variations of silicon, iron and copper alloy Al-Cu (206) on the mechanical properties, and ii) certain relationships between the mechanism of hot cracking and the solidification rate in semi-solid. Parts produced from the semi-solid paste coming from the SEED process combined with modified 206 alloys have been successfully molded and achieved superior mechanical properties than the requirements of the automotive industry. The fatigue properties of the two best modified 206 alloys were higher than those of A357 alloy castings and are close to those of the

  6. Clinical Analysis of TSC-associated Renal Angiomyolipomas:A Report of 206 Cases%结节性硬化症相关肾错构瘤206例临床分析

    Institute of Scientific and Technical Information of China (English)

    廖勇; 陶客言; 黄建林; 李俊; 何鹏; 邹建华; 邱明星; 熊国兵

    2015-01-01

    目的:总结诊治伴发结节性硬化症( TSC)的肾错构瘤( AML)患者病例资料,并系统回顾30年国内相关文献资料,以期为认识该病特征、提高对其诊疗水平提供参考。方法总结我院诊治首例伴发结节性硬化症肾错构瘤患者病例资料,同时检索中国生物医学文献数据库( Sinomed)与PubMed,按照预先确定标准对检索文献进行汇总,分析纳入合格文献的研究特征、研究内容,总结该病特点及诊疗要点。结果纳入共计206例患者,年龄2个月~77岁,男女比例63:70。96例患者包含肾脏肿瘤情况,肿瘤大小为0.4cm~45cm,其中10cm者39例。95例包含治疗方法,34例(25.68%)采用保守治疗,26例(24.32%)采用保留肾单位手术,25例(28.38%)采用肾切除术,10例(13.51%)采用选择性肾动脉栓塞。结果倾向于小体积肿瘤保守治疗、大体积行RN或NSS及独肾行NSS。25个研究报告了患者肾功能,而手术中仅4个研究报告患者肾功能不全。没有研究陈述具体结局评估,仅21个研究(28.38%)不规范地报道随访结局,随访时间1天~5年。结论提高对结节性硬化症相关肾错构瘤疾病特征的认识,加强多学科合作,推荐遵循国际化诊疗指南进行规范诊治。对于症状性TSC相关肾AML,保留肾组织的外科干预应当首先考虑。应综合考虑肿瘤大小、肾脏功能、症状表现以及患者情况,实施个体化治疗。%Objective The data of first hospitalized patient with Tuberous Sclerosis complex( TSC)-associated renal an-giomyolipomas managed by our team was analyzed, and the related studies of TSC-associated renal angiomyolipomas of the past 30 years in mainland China were systematic reviewed retrospectively, so as to improve the reorganization of corresponding diseases characteristics and the diagnosis and treatment level. Methods Combining analysis of the first case of TSC-associated renal an-giomyolipomas in our hospital, data sources of relevant

  7. CD206+ Cell Number Differentiates Influenza A (H1N1)pdm09 from Seasonal Influenza A Virus in Fatal Cases

    Science.gov (United States)

    Rodriguez-Ramirez, Heidi G.; Salinas-Carmona, Mario C.; Barboza-Quintana, Oralia; Melo-de la Garza, Americo; Ceceñas-Falcon, Luis Angel; Rangel-Martinez, Lilia M.; Rosas-Taraco, Adrian G.

    2014-01-01

    In 2009, a new influenza A (H1N1) virus affected many persons around the world. There is an urgent need for finding biomarkers to distinguish between influenza A (H1N1)pdm09 and seasonal influenza virus. We investigated these possible biomarkers in the lung of fatal cases of confirmed influenza A (H1N1)pdm09. Cytokines (inflammatory and anti-inflammatory) and cellular markers (macrophages and lymphocytes subpopulation markers) were analyzed in lung tissue from both influenza A (H1N1)pdm09 and seasonal influenza virus. High levels of IL-17, IFN-γ, and TNF-α positive cells were identical in lung tissue from the influenza A (H1N1)pdm09 and seasonal cases when compared with healthy lung tissue (P < 0.05). Increased IL-4+ cells, and CD4+ and CD14+ cells were also found in high levels in both influenza A (H1N1)pdm09 and seasonal influenza virus (P < 0.05). Low levels of CD206+ cells (marker of alternatively activated macrophages marker in lung) were found in influenza A (H1N1)pdm09 when compared with seasonal influenza virus (P < 0.05), and the ratio of CD206/CD14+ cells was 2.5-fold higher in seasonal and noninfluenza group compared with influenza A (H1N1)pdm09 (P < 0.05). In conclusion, CD206+ cells differentiate between influenza A (H1N1)pdm09 and seasonal influenza virus in lung tissue of fatal cases. PMID:25614715

  8. CD206+ Cell Number Differentiates Influenza A (H1N1pdm09 from Seasonal Influenza A Virus in Fatal Cases

    Directory of Open Access Journals (Sweden)

    Heidi G. Rodriguez-Ramirez

    2014-01-01

    Full Text Available In 2009, a new influenza A (H1N1 virus affected many persons around the world. There is an urgent need for finding biomarkers to distinguish between influenza A (H1N1pdm09 and seasonal influenza virus. We investigated these possible biomarkers in the lung of fatal cases of confirmed influenza A (H1N1pdm09. Cytokines (inflammatory and anti-inflammatory and cellular markers (macrophages and lymphocytes subpopulation markers were analyzed in lung tissue from both influenza A (H1N1pdm09 and seasonal influenza virus. High levels of IL-17, IFN-γ, and TNF-α positive cells were identical in lung tissue from the influenza A (H1N1pdm09 and seasonal cases when compared with healthy lung tissue (P<0.05. Increased IL-4+ cells, and CD4+ and CD14+ cells were also found in high levels in both influenza A (H1N1pdm09 and seasonal influenza virus (P<0.05. Low levels of CD206+ cells (marker of alternatively activated macrophages marker in lung were found in influenza A (H1N1pdm09 when compared with seasonal influenza virus (P<0.05, and the ratio of CD206/CD14+ cells was 2.5-fold higher in seasonal and noninfluenza group compared with influenza A (H1N1pdm09 (P<0.05. In conclusion, CD206+ cells differentiate between influenza A (H1N1pdm09 and seasonal influenza virus in lung tissue of fatal cases.

  9. A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana; Bajgar, Jiri; Kuca, Kamil; Musilek, Kamil

    2008-12-01

    The potency of newly developed bispyridinium compounds (K206, K269) in reactivating tabun-inhibited acetylcholinesterase and eliminating tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods. Studies which determined percentage of reactivation of tabun-inhibited blood and tissue AChE in poisoned rats showed that the reactivating efficacy of both newly developed oximes is comparable with obidoxime and trimedoxime in blood but lower than the reactivating potency of trimedoxime and obidoxime in the diaphragm and brain. Nevertheless, the differences in reactivating efficacy of obidoxime, trimedoxime and K206 was not significant while the potency of K269 to reactivate tabun-inhibited acetylcholinesterase was significantly lower. Both newly developed oximes were also found to be relatively efficacious in elimination of the lethal toxic effects in tabun-poisoned mice. Their therapeutic efficacy corresponds to the therapeutic potency of obidoxime. The oxime HI-6, relatively efficacious against soman, did not seem to be an adequately effective oxime in reactivation of tabun-inhibited AChE and to counteract lethal effects of tabun. Both newly developed oximes (K206, K269) are significantly more efficacious in reactivating tabun-inhibited AChE in rats and to eliminate lethal toxic effects of tabun in mice than the oxime HI-6 but their reactivating and therapeutic potency does not prevail over the effectiveness of currently available obidoxime and trimedoxime and, therefore, they are not suitable for their replacement of commonly used oximes for the treatment of acute tabun poisoning.

  10. Lead fluxes and 206Pb/207Pb isotope ratios in rime and snow collected at remote mountain-top locations (Czech Republic, Central Europe): Patterns and sources

    Science.gov (United States)

    Cimova, Nikoleta; Novak, Martin; Chrastny, Vladislav; Curik, Jan; Veselovsky, Frantisek; Blaha, Vladimir; Prechova, Eva; Pasava, Jan; Houskova, Marie; Bohdalkova, Leona; Stepanova, Marketa; Mikova, Jitka; Krachler, Michael; Komarek, Arnost

    2016-10-01

    During three winter seasons (2009-2011), Pb concentrations were measured in precipitation at 10 high-elevation sites in the Czech Republic, close to the borders with Austria, Germany, Poland, and Slovakia. Soluble and insoluble Pb forms were quantified in snow (vertical deposition), and rime (horizontal deposition). The objective was to compare Pb input fluxes into ecosystems via vertical and horizontal deposition, and to identify the residual Pb pollution sources in an era of rapidly decreasing industrial pollution. Lead soluble in diluted HNO3 made up 96% of total Pb deposition, with the remaining 4% Pb bound mainly in silicates. Three times higher concentrations of soluble Pb in rime than in snow, and 2.5 times higher concentrations of insoluble Pb in rime than in snow were associated with slightly different Pb isotope ratios. On average, the 206Pb/207Pb ratios in rime were higher than those in snow. Higher mean 206Pb/207Pb ratios of insoluble Pb (1.175) than in soluble Pb (1.165) may indicate an increasing role of geogenic Pb in recent atmospheric deposition. A distinct reversal to more radiogenic 206Pb/207Pb ratios in snow and rime in 2010, compared to literature data from rain-fed Sphagnum peatlands (1800-2000 A.D.), documented a recent decrease in anthropogenic Pb in the atmosphere of Central Europe. Since the early 1980s, Pb concentrations in snow decreased 18 times in the rural south of the Czech Republic, but only twice in the industrial north of the Czech Republic. Isotope signatures indicated that Pb in today's atmospheric deposition is mainly derived from Mesozoic ores mined/processed in Poland and coal combustion in the Czech Republic and Poland.

  11. Testing the Mutually Enhanced Magicity Effect in Nuclear Incompressibility via the Giant Monopole Resonance in the $^{204,206,208}$Pb Isotopes

    CERN Document Server

    Patel, D; Fujiwara, M; Adachi, T; Akimune, H; Berg, G P A; Harakeh, M N; Itoh, M; Iwamoto, C; Long, A; Matta, J T; Murakami, T; Okamoto, A; Sault, K; Talwar, R; Uchida, M; Yosoi, M

    2013-01-01

    Using inelastic $\\alpha$-scattering at extremely forward angles, including $0^\\circ$, the strength distributions of the isoscalar giant monopole resonance (ISGMR) have been measured in the $^{204,206,208}$Pb isotopes in order to examine the proposed mutually enhanced magicity (MEM) effect on the nuclear incompressibility. The MEM effect had been suggested as a likely explanation of the "softness" of nuclear incompressibility observed in the ISGMR measurements in the Sn and Cd isotopes. Our experimental results rule out any manifestation of the MEM effect in nuclear incompressibility and leave the question of the softness of the open-shell nuclei unresolved still.

  12. L206W mutation of the cystic fibrosis gene, relatively frequent in French Canadians, is associated with atypical presentations of cystic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Rozen, R.; Ferreira-Rajabi, L.; Robb, L. [McGill Univ., Montreal, Quebec (Canada)] [and others

    1995-07-03

    Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Over 400 mutations have been reported at this locus. Although severe forms of cystic fibrosis are usually associated with pancreatic insufficiency, pulmonary dysfunction, and elevated sweat chloride, there is a wide range of phenotypes, including congenital absence of the vas deferens, observed with some of the milder mutations. The L206W mutation, which was first identified in patients from South France, is relatively frequent in French Canadians from Quebec. In this report, we document the atypical form of cystic fibrosis associated with this mutation in a cohort of 7 French Canadian probands. 20 refs.

  13. International Civil Aviation Organization Helicopter Noise Measurement Repeatability Program: U.S. Test Report, Bell 206L-1, Noise Measurement Flight Test,

    Science.gov (United States)

    1985-09-01

    Helicopter Textron, from Omniflight Inc., located at Martin State Airport in Baltimore, Maryland. Prior to the test a laser retroreflector (shown in Figure 15...was mounted on the underside of the test vehicle. The retroreflector constitutes the only external difference between the US test vehicle and 206L-1...44 ,’-’ TABLE J. 39 TABLE J.37 " , DAM . 8-26.8 DA1IE 8-27-4 (aTI N: MAD 6 APL A 57 [1S. a:&ATIW : LED) 0.9 Vh 117 [MS. : I :P :1 RATE (F ALT RAM

  14. Analysis on birth weight of 206 165 newborns in Shanghai%上海市闵行区206 165例新生儿出生体重分析

    Institute of Scientific and Technical Information of China (English)

    黄俊; 刘蒲; 李云; 王娜; 夏红; 姜庆五

    2013-01-01

    [Objective] To assess the birth weight of live births with gestational age from 28 to 42 weeks in Minhang District and identify the related factors to provide evidences for improving newborns' constitution. [Methods] Data on birth weight and other related factors for newborns born during Jan. 2006 — Nov. 2011 were collected by the population-based electronic Health Records (eHR) system in Minhang District,Shanghai,China. [Results] A total of 206 165 live newborns were enrolled in this analysis. The mean and median birth weight were 3 343 g and 3 320 g for all newborns. Low birth weight rates were 0. 6% and 0. 9% of male and female newborns, while macrosomia accounted for 9. 0% and 5. 1% .respectively. The percentage of low birth weight and macrosomia, the average birth weight, gestational age and mothers age were significantly different between males and females (P<0. 05). Mean birth weight also differed by sex, birth calendar year,gestational age,mother's age,mode of delivery, residence type and health condition of mother(P<0. 05). [Conclusion] The average birth weight in live births is affected by several factors. Appropriate measures should be implemented to improve the situation.%[目的] 了解上海市闵行区常住居民足月新生儿出生体重的现况及其相关因素,为提高新生儿出生人口体质提供参考依据. [方法] 收集2006年1月-2011年11月上海市闵行区居民健康档案系统中登记建卡的新生儿出生体重及相关信息进行研究. [结果] 共有206165例新生儿纳入本研究,出生体重均数及中位数分别为3343 g、3320g.男女低体重儿比例分别为0.6%、0.9%;巨大儿比例分别为9.0%、5.1%.低体重比例、巨大儿比例、出生体重均数、孕周和母亲怀孕年龄在男女间差异有统计学意义(P<0.05).性别、出生年份、孕周、母亲怀孕年龄、分娩方式、户口类型、母亲健康状况均对出生体重均数有影响(P<0.05). [结论] 新生

  15. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation.

    Science.gov (United States)

    Chakkalakal, Salin A; Uchibe, Kenta; Convente, Michael R; Zhang, Deyu; Economides, Aris N; Kaplan, Frederick S; Pacifici, Maurizio; Iwamoto, Masahiro; Shore, Eileen M

    2016-09-01

    Fibrodysplasia ossificans progressiva (FOP), a rare and as yet untreatable genetic disorder of progressive extraskeletal ossification, is the most disabling form of heterotopic ossification (HO) in humans and causes skeletal deformities, movement impairment, and premature death. Most FOP patients carry an activating mutation in a bone morphogenetic protein (BMP) type I receptor gene, ACVR1(R206H) , that promotes ectopic chondrogenesis and osteogenesis and, in turn, HO. We showed previously that the retinoic acid receptor γ (RARγ) agonist palovarotene effectively inhibited HO in injury-induced and genetic mouse models of the disease. Here we report that the drug additionally prevents spontaneous HO, using a novel conditional-on knock-in mouse line carrying the human ACVR1(R206H) mutation for classic FOP. In addition, palovarotene restored long bone growth, maintained growth plate function, and protected growing mutant neonates when given to lactating mothers. Importantly, palovarotene maintained joint, limb, and body motion, providing clear evidence for its encompassing therapeutic potential as a treatment for FOP. © 2016 American Society for Bone and Mineral Research.

  16. Grazing-induced changes in muscle microRNA-206 and -208b expression in association with myogenic gene expression in cattle.

    Science.gov (United States)

    Horikawa, Akihiko; Ogasawara, Hideki; Okada, Kaito; Kobayashi, Misato; Muroya, Susumu; Hojito, Masayuki

    2015-11-01

    To investigate the roles of microRNAs (miRNAs) in muscle type conversion, the effects of 4 months of grazing on the expression levels of miRNAs and mRNAs associated with skeletal muscle development were analyzed by quantitative RT-PCR using the Biceps femoris muscle of Japanese Shorthorn cattle. After 4 months of grazing, the expression of muscle fiber type-associated miR-208b was higher in the grazed cattle than in the housed. In concordance with the pattern in miR-208b expression, the expression of MyoD, a myogenic regulatory factor associated with the shifting of muscle property to the fast type, was lower in the grazed cattle after 4 months of grazing than in the housed cattle. In addition, the expression of MyHC-2x (a fast type) was higher in the housed cattle than in the grazed, after 4 months of grazing. During the grazing period, miR-206 expression decreased in the housed cattle, whereas expression in the grazed cattle did not change, but rather remained higher than that of the housed cattle even at 3 months after the grazing ended. These miRNAs including miR-206 persisting with muscles of grazed cattle may be associated with regulation of muscle gene expression during skeletal muscle adaptation to grazing.

  17. Schizophrenia risk variants affecting microRNA function and site-specific regulation of NT5C2 by miR-206.

    Science.gov (United States)

    Hauberg, Mads Engel; Holm-Nielsen, Marie Hebsgaard; Mattheisen, Manuel; Askou, Anne Louise; Grove, Jakob; Børglum, Anders Dupont; Corydon, Thomas Juhl

    2016-09-01

    Despite the identification of numerous schizophrenia-associated genetic variants, few have been examined functionally to identify and characterize the causal variants. To mitigate this, we aimed at identifying functional variants affecting miRNA function. Using data from a large-scale genome-wide association study of schizophrenia, we looked for schizophrenia risk variants altering either miRNA binding sites, miRNA genes, promoters for miRNA genes, or variants that were expression quantitative trait loci (eQTLs) for miRNA genes. We hereby identified several potentially functional variants relating to miRNA function with our top finding being a schizophrenia protective allele that disrupts miR-206׳s binding to NT5C2 thus leading to increased expression of this gene. A subsequent experimental follow-up of the variant using a luciferase-based reporter assay confirmed that the allele disrupts the binding. Our study therefore suggests that miR-206 may contribute to schizophrenia risk through allele-dependent regulation of the genome-wide significant gene NT5C2.

  18. Advances in Interlaboratory Testing and Evaluation of Bituminous Materials State-of-the-Art Report of the RILEM Technical Committee 206-ATB

    CERN Document Server

    Bahia, Hussain; Canestrari, Francesco; Roche, Chantal; Benedetto, Hervé; Piber, Herald; Sybilski, Dariusz

    2013-01-01

    This STAR on asphalt materials presents the achievements of RILEM TC 206 ATB, acquired over many years of interlaboratory tests and international knowledge exchange. It covers experimental aspects of bituminous binder fatigue testing; the background on compaction methods and imaging techniques for characterizing asphalt mixtures including validation of a new imaging software; it focuses on experimental questions and analysis tools regarding mechanical wheel tracking tests, comparing results from different labs and using finite element techniques. Furthermore, long-term rutting prediction and evaluation for an Austrian road are discussed, followed by an extensive analysis and test program on interlayer bond testing of three different test sections which were specifically constructed for this purpose. Finally, the key issue of manufacturing reclaimed hot mix asphalt in the laboratory is studied and recommendations for laboratory ageing of bituminous mixtures are given.

  19. Mapping the boundaries of the seniority regime and collective motion: Coulomb excitation studies of N = 122 isotones $^{206}$Po and $^{208}$Rn

    CERN Multimedia

    Butler, P; Voulot, D; Rahkila, P J; Darby, I G; Grahn, T; Bree, N C F; Julin, R J; Diriken, J V J; Jenkins, D G; Kroell, T; Huyse, M L

    In regions near magic nuclei, seniority can be regarded as a good quantum number. In the N = 122 isotones above the Z = 82 shell closure relative high-$\\textit{j}\\,$ single-particle proton orbitals dominate the structure and thus levels up to $\\textit{I}$ = 2$\\textit{j}$ - 1 could, in principle, be understood within the seniority scheme. While B(E2) values usually increase within the band with increasing $\\textit{I}$, the seniority scheme can lead to a contrasting result. The present proposal addresses this phenomenon through the measurements of previously unknown B(E2; 0$^{+}\\rightarrow$ 2$^{+}$) values in $^{206}$Po and $^{208}$Rn. The proposed Coulomb excitation measurements of radioactive beams will be carried out at the REX-ISOLDE facility using the MINIBALL $\\gamma$-ray spectrometer.

  20. Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models.

    Science.gov (United States)

    Maeda, Hitoshi; Hirata, Kenshiro; Watanabe, Hiroshi; Ishima, Yu; Chuang, Victor Tuan Giam; Taguchi, Kazuaki; Inatsu, Akihito; Kinoshita, Manabu; Tanaka, Motohiko; Sasaki, Yutaka; Otagiri, Masaki; Maruyama, Toru

    2015-02-01

    Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68(+) KC, play a key role in the induction of hepatic oxidative stress and injuries, we developed a polythiolated- and mannosylated human serum albumin (SH-Man-HSA), which functions as a novel nanoantioxidant for delivering thiol to CD68(+) KC. In vitro electron paramagnetic resonance coupled with pharmacokinetics and immunohistochemical studies showed that SH-Man-HSA possessed powerful radical-scavenging activity and rapidly and selectively delivered thiols to the liver via mannose receptor (CD206) on CD68(+) cells. SH-Man-HSA significantly improved the survival rate of concanavalin-A (Con-A)-treated mice. Moreover, SH-Man-HSA exhibited excellent hepatoprotective functions, not by decreasing tumor necrosis factor or interferon-γ production that is closely associated with Con-A-induced hepatitis, but by suppressing ROS production. Interestingly, the protective effect of SH-Man-HSA was superior to N-acetyl cysteine (NAC). This could be attributed to the difference in the inhibition of hepatic oxidative stress between the two antioxidants depending on their potential for thiol delivery to the liver. Similar results were also observed for acetaminophen (APAP)-induced hepatopathy models. Flow cytometric data further confirmed that an increase in F4/80(+)/ROS(+) cells was dramatically decreased by SH-Man-HSA. The administration of SH-Man-HSA at 4 hours following a Con-A or APAP injection also exhibited a profound hepatoprotective action against these hepatitis models, whereas this was not observed for NAC. It can be concluded therefore that SH-Man-HSA has great potential for use in a rescue therapy for hepatopathy as a nanoantioxidant because of its ability to efficiently and rapidly deliver thiols to CD68(+)/CD206(+) KC.

  1. Excitation functions of residual nuclei production from 40–2600 MeV proton-irradiated 206,207,208,natPb and 209Bi

    Indian Academy of Sciences (India)

    Yu E Titarenko; V F Batyaev; V M Zhivun; V O Kudryashov; K A Lipatov; A V Ignatyuk; S G Mashnik

    2007-02-01

    The work is aimed at experimental determination of the independent and cumulative yields of radioactive residual nuclei produced in intermediate-energy proton-irradiated thin targets made of highly isotopic enriched and natural lead (206,207,208,natPb) and 209Bi. 5972 radioactive product nuclide yields have been measured in 55 thin targets induced by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6 and 2.6 GeV protons extracted from the ITEP U-10 proton synchrotron. The measured data have been compared with data obtained at other laboratories as well as with theoretical simulations by seven codes. We found that the predictive power of the tested codes is different but is satisfactory for most of the nuclides in the spallation region, though none of the codes agree well with the data in the whole mass region of product nuclides and all should be improved further.

  2. Depth profile of production yields of natPb(p, xn) 206,205,204,203,202,201Bi nuclear reactions

    Science.gov (United States)

    Mokhtari Oranj, Leila; Jung, Nam-Suk; Kim, Dong-Hyun; Lee, Arim; Bae, Oryun; Lee, Hee-Seock

    2016-11-01

    Experimental and simulation studies on the depth profiles of production yields of natPb(p, xn) 206,205,204,203,202,201Bi nuclear reactions were carried out. Irradiation experiments were performed at the high-intensity proton linac facility (KOMAC) in Korea. The targets, irradiated by 100-MeV protons, were arranged in a stack consisting of natural Pb, Al, Au foils and Pb plates. The proton beam intensity was determined by activation analysis method using 27Al(p, 3p1n)24Na, 197Au(p, p1n)196Au, and 197Au(p, p3n)194Au monitor reactions and also by Gafchromic film dosimetry method. The yields of produced radio-nuclei in the natPb activation foils and monitor foils were measured by HPGe spectroscopy system. Monte Carlo simulations were performed by FLUKA, PHITS/DCHAIN-SP, and MCNPX/FISPACT codes and the calculated data were compared with the experimental results. A satisfactory agreement was observed between the present experimental data and the simulations.

  3. OGLE-2012-BLG-0455/MOA-2012-BLG-206: Microlensing event with ambiguity in planetary interpretations caused by incomplete coverage of planetary signal

    CERN Document Server

    Park, H; Gould, A; Udalski, A; Sumi, T; Fouqué, P; Choi, J -Y; Christie, G; Depoy, D L; Dong, Subo; Gaudi, B S; Hwang, K -H; Jung, Y K; Kavka, A; Lee, C -U; Monard, L A G; Natusch, T; Ngan, H; Pogge, R W; Shin, I -G; Yee, J C; Szymański, M K; Kubiak, M; Soszyński, I; Pietrzyński, G; Poleski, R; Ulaczyk, K; Pietrukowicz, P; Kozłowski, S; Skowron, J; Wyrzykowski, Ł; Abe, F; Bennett, D P; Bond, I A; Botzler, C S; Chote, P; Freeman, M; Fukui, A; Fukunaga, D; Harris, P; Itow, Y; Koshimoto, N; Ling, C H; Masuda, K; Matsubara, Y; Muraki, Y; Namba, S; Ohnishi, K; Rattenbury, N J; Saito, To; Sullivan, D J; Sweatman, W L; Suzuki, D; Tristram, P J; Wada, K; Yamai, N; Yock, P C M; Yonehara, A

    2014-01-01

    Characterizing a microlensing planet is done from modeling an observed lensing light curve. In this process, it is often confronted that solutions of different lensing parameters result in similar light curves, causing difficulties in uniquely interpreting the lens system, and thus understanding the causes of different types of degeneracy is important. In this work, we show that incomplete coverage of a planetary perturbation can also result in degenerate solutions even for events where the planetary signal is detected with a high level of statistical significance. We demonstrate the degeneracy for an actually observed event OGLE-2012-BLG-0455/MOA-2012-BLG-206. The peak of this high-magnification event $(A_{\\rm max}\\sim400)$ exhibits very strong deviation from a point-lens model with $\\Delta\\chi^{2}\\gtrsim4000$. From detailed modeling of the light curve, we find that the deviation can be explained by four distinct solutions, i.e., two very different sets of solutions, each with a two-fold degeneracy. While th...

  4. Influence of thermomechanical processing on biomechanical compatibility and electrochemical behavior of new near beta alloy, Ti-20.6Nb-13.6Zr-0.5V

    Directory of Open Access Journals (Sweden)

    Mohammed MT

    2015-10-01

    Full Text Available Mohsin Talib Mohammed,1 Zahid A Khan,1 Geetha Manivasagam,2 Arshad N Siddiquee1 1Mechanical Engineering Department, Faculty of Engineering, Jamia Millia Islamia, New Delhi, 2Centre for Biomaterials Science and Technology, VIT University, Vellore, India Abstract: This paper presents the results for the effect of different methods of thermomechanical processing on the mechanical properties and electrochemical behavior of metastable β alloy Ti-20.6Nb-13.6Zr-0.5V (TNZV. The thermomechanical processing included hot working, solution heat treatments at different temperatures, and cooling rates in addition to aging. The thermomechanical processing conditions used in the study resulted in attainment of a wide range of microstructures with varying spatial distributions and morphologies of elongated/equiaxed α, β phases, or martensite, as a result of which several tensile properties were achieved. Aging treatment led to an increase in hardness, elastic modulus, and tensile strength and a decrease in ductility (elongation. Electrochemical tests indicated that the TNZV alloy undergoes spontaneous passivation due to spontaneous formation of an oxide film in the environment of the human body. Because the air-cooled samples possessed high hardness and also a fine grain size, they showed a lower corrosion rate than the samples treated under other conditions. Keywords: titanium alloys, biomedical applications, mechanical properties, corrosion

  5. Altered Levels of MicroRNA-9, -206, and -132 in Spinal Muscular Atrophy and Their Response to Antisense Oligonucleotide Therapy.

    Science.gov (United States)

    Catapano, Francesco; Zaharieva, Irina; Scoto, Mariacristina; Marrosu, Elena; Morgan, Jennifer; Muntoni, Francesco; Zhou, Haiyan

    2016-07-05

    The identification of noninvasive biomarkers to monitor the disease progression in spinal muscular atrophy (SMA) is becoming increasingly important. MicroRNAs (miRNAs) regulate gene expression and are implicated in the pathogenesis of neuromuscular diseases, including motor neuron degeneration. In this study, we selectively characterized the expression of miR-9, miR-206, and miR-132 in spinal cord, skeletal muscle, and serum from SMA transgenic mice, and in serum from SMA patients. A systematic analysis of miRNA expression was conducted in SMA mice with different disease severities (severe type I-like and mild type III-like) at different disease stages (pre-, mid-, and late-symptomatic stages), and in morpholino antisense oligonucleotide-treated mice. There was differential expression of all three miRNAs in spinal cord, skeletal muscle and serum samples in SMA mice. Serum miRNAs were altered prior to the changes in spinal cord and skeletal muscle at the presymptomatic stage. The altered miR-132 levels in spinal cord, muscle, and serum transiently reversed to normal level after a single-dose morpholino antisense oligomer PMO25 treatment in SMA mice. We also confirmed a significant alteration of miR-9 and miR-132 level in serum samples from SMA patients. Our study indicates the potential of developing miRNAs as noninvasive biomarkers in SMA.

  6. Effects of Iron-Rich Intermetallics and Grain Structure on Semisolid Tensile Properties of Al-Cu 206 Cast Alloys near Solidus Temperature

    Science.gov (United States)

    Bolouri, Amir; Liu, Kun; Chen, X.-Grant

    2016-12-01

    The effects of iron-rich intermetallics and grain size on the semisolid tensile properties of Al-Cu 206 cast alloys near the solidus were evaluated in relation to the mush microstructure. Analyses of the stress-displacement curves showed that the damage expanded faster in the mush structure dominated by plate-like β-Fe compared to the mush structure dominated by Chinese script-like α-Fe. While there was no evidence of void formation on the β-Fe intermetallics, they blocked the interdendritic liquid channels and thus hindered liquid flow and feeding during semisolid deformation. In contrast, the interdendritic liquid flows more freely within the mush structure containing α-Fe. The tensile properties of the alloy containing α-Fe are generally higher than those containing β-Fe over the crucial liquid fraction range of 0.6 to 2.8 pct, indicating that the latter alloy may be more susceptible to stress-related casting defects such as hot tearing. A comparison of the semisolid tensile properties of the alloy containing α-Fe with different grain sizes showed that the maximum stress and elongation of the alloy with finer grains were moderately higher for the liquid fractions of 2.2 to 3.6 pct. The application of semisolid tensile properties for the evaluation of the hot tearing susceptibility of experimental alloys is discussed.

  7. J-UNIO protocol used for NMR structure determination of the 206-residue protein NP-346487.1 from Streptococcus pneumoniae TIGR4

    Energy Technology Data Exchange (ETDEWEB)

    Jaudzems, Kristaps [Latvian Institute of Organic Synthesis (Latvia); Pedrini, Bill [Paul Scherrer Institute (PSI), SwissFEL Project (Switzerland); Geralt, Michael; Serrano, Pedro; Wüthrich, Kurt, E-mail: wuthrich@scripps.edu [The Scripps Research Institute, Department of Integrative Structural and Computational Biology (United States)

    2015-01-15

    The NMR structure of the 206-residue protein NP-346487.1 was determined with the J-UNIO protocol, which includes extensive automation of the structure determination. With input from three APSY-NMR experiments, UNIO-MATCH automatically yielded 77 % of the backbone assignments, which were interactively validated and extended to 97 %. With an input of the near-complete backbone assignments and three 3D heteronuclear-resolved [{sup 1}H,{sup 1}H]-NOESY spectra, automated side chain assignment with UNIO-ATNOS/ASCAN resulted in 77 % of the expected assignments, which was extended interactively to about 90 %. Automated NOE assignment and structure calculation with UNIO-ATNOS/CANDID in combination with CYANA was used for the structure determination of this two-domain protein. The individual domains in the NMR structure coincide closely with the crystal structure, and the NMR studies further imply that the two domains undergo restricted hinge motions relative to each other in solution. NP-346487.1 is so far the largest polypeptide chain to which the J-UNIO structure determination protocol has successfully been applied.

  8. The non-evolving internal structure of early-type galaxies: the case study SDSS J0728+3835 at z = 0.206

    CERN Document Server

    Barnabe, Matteo; Treu, Tommaso; Koopmans, Leon; Bolton, Adam S; Czoske, Oliver; Gavazzi, Raphael

    2010-01-01

    We study the internal dynamical structure of the early-type lens galaxy SDSS J0728+3835 at z = 0.206. The analysis is based on two-dimensional kinematic maps extending out to 1.7 effective radii obtained from Keck spectroscopy, and lensing geometry and stellar mass estimates obtained from multiband Hubble Space Telescope imaging. The data are modeled under the assumptions of axial symmetry supported by a two-integral distribution function (DF), by applying the combined gravitational lensing and stellar dynamics code CAULDRON, and yielding high-quality constraints for an early-type galaxy at cosmological redshifts. We find that the total density profile is nearly isothermal (rho_tot ~ 1/r^{gamma} with logarithmic slope gamma = 2.08^{+0.04}_{-0.02}), and quite flattened (axial ratio q = 0.60^{+0.08}_{-0.03}). The galaxy is mildly anisotropic (delta = 0.08 +/- 0.02) and shows a fair amount of rotational support, in particular towards the outer regions. We determine a dark matter fraction lower limit of 28 per ce...

  9. 解读国际标准CODEX STAN 206《乳品术语通则》——兼论本土奶牛养殖业的竞争力优势

    Institute of Scientific and Technical Information of China (English)

    顾佳升; 李梅

    2013-01-01

    本文以国际食品法典CODEX STAN 206标准为主,以其他国际标准为辅,与我国相关标准作比较分析,进而从法规和标准的角度,探索中国本土奶牛养殖业的竞争力优势所在及其生存底线.

  10. Research of relative factors between bronchiolitis and asthma by long time follow-up of 206 children bronchiolitis patients%长期随访206例毛细支气管炎患儿发展为哮喘的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    刘志刚

    2014-01-01

    OBJECTIVE:206 children bronchiolitis patients with the hospitalization treatment were fol owed up long time, then the relative factors between bronchiolitis and asthma were analyzed. METHODS:The data of 206 children bronchiolitis patients with the hospitalization treatment were retrospectively analyzed. Al the children were fol owed up for three years. Sex, family history,childbirth,feeding pat erns,al ergy history,immunoglobulin,intestinal tract probiotics,inhaled corticosteroid,al ergic constitution, repeat respiratory tract infections and passive smoking were observed. Logistic regression analysis was used to analyze the relationship between the factors and asthma. RESULTS:48 of 206 patients (23.3%) with bronchiolitis converted to asthma. Univariate analysis results showed that there were significant difference of family history, immunoglobulin, feeding pat erns, inhaled corticosteroid, al ergic constitution and passive smoking between the chil-dren with or without asthma (P﹤0.05). Logistic regression analysis showed that family history, al ergic constitution , repeat respiratory tract infections and passive smoking were the risk factors for asthma, and breast feeding,inhaled corticosteroid, repeat respiratory tract infections and immunoglobulin were the protective factors. CONCLUSION:Family history, Individual al ergic constitution,respiratory tract infections and passive smoking were the risk factors for asthma. Breast feed-ing,inhaled corticosteroid treatment , intestinal tract probiotics and immunoglobulin wil decrease the occurrence of asthma.%目的:对住院治疗的206例毛细支气管炎患儿进行随访2年,对其中可能是发展为哮喘的影响因素进行分析。方法:对住院治疗的206例毛细支气管炎患儿临床资料进行回顾性分析,所有患儿均随访2年。对性别、家族史、生产史、喂养史、过敏史、丙种球蛋白、益生菌应用史、吸入糖皮质激素及被动吸烟可能是发展为哮

  11. Line parameters including temperature dependences of air- and self-broadened line shapes of 12C16O2: 2.06-μm region

    Science.gov (United States)

    Benner, D. Chris; Devi, V. Malathy; Sung, Keeyoon; Brown, Linda R.; Miller, Charles E.; Payne, Vivienne H.; Drouin, Brian J.; Yu, Shanshan; Crawford, Timothy J.; Mantz, Arlan W.; Smith, Mary Ann H.; Gamache, Robert R.

    2016-08-01

    This study reports the results from analyzing a number of high resolution, high signal-to-noise ratio (S/N) spectra in the 2.06-μm spectral region for pure CO2 and mixtures of CO2 in dry air. A multispectrum nonlinear least squares curve fitting technique has been used to retrieve the various spectral line parameters. The dataset includes 27 spectra: ten pure CO2, two 99% 13C-enriched CO2 and fifteen spectra of mixtures of 12C-enriched CO2 in dry air. The spectra were recorded at various gas sample temperatures between 170 and 297 K. The absorption path lengths range from 0.347 to 49 m. The sample pressures for the pure CO2 spectra varied from 1.1 to 594 Torr; for the two 13CO2 spectra the pressures were ∼10 and 146 Torr. For the air-broadened spectra, the pressures of the gas mixtures varied between 200 and 711 Torr with CO2 volume mixing ratios ranging from 0.014% to 0.203%. The multispectrum fitting technique was applied to fit simultaneously all these spectra to retrieve consistent set of line positions, intensities, and line shape parameters including their temperature dependences; for this, the Voigt line shape was modified to include line mixing (via the relaxation matrix formalism) and quadratic speed dependence. The new results are compared to select published values, including recent ab initio calculations. These results are required to retrieve the column averaged dry air mole fraction (XCO2) from space-based observations, such as the Orbiting Carbon Observatory-2 (OCO-2) satellite mission that NASA launched in July 2014.

  12. The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production.

    Science.gov (United States)

    Paveley, Ross A; Aynsley, Sarah A; Turner, Joseph D; Bourke, Claire D; Jenkins, Stephen J; Cook, Peter C; Martinez-Pomares, Luisa; Mountford, Adrian P

    2011-11-01

    In this study, infective larvae of the parasitic helminth Schistosoma mansoni were shown to contain a large number of glycosylated components specific for the Mannose Receptor (MR; CD206), which is an important pattern recognition receptor (PRR) of the innate immune system. MR ligands were particularly rich in excretory/secretory (E/S) material released during transformation of cercariae into schistosomula, a process critical for infection of the host. E/S material from carboxyfluorescein diacetate succinimidyl ester (CFDA-SE)-labelled cercariae showed enhanced binding by cells lines that over-express the MR. Conversely, uptake was significantly lower by bone marrow-derived macrophages (MΦ) from MR(-/-) mice, although they were more active as judged by enhanced pro-inflammatory cytokine production and CD40 expression. After natural percutaneous infection of MR(-/-) mice with CFDA-SE-labelled parasites, there were fewer cells in the skin and draining lymph nodes that were CFDA-SE(+) compared with wild-type mice, implying reduced uptake and presentation of larval parasite antigen. However, antigen-specific proliferation of skin draining lymph node cells was significantly enhanced and they secreted markedly elevated levels of IFNγ but decreased levels of IL-4. In conclusion, we show that the MR on mononuclear phagocytic cells, which are plentiful in the skin, plays a significant role in internalising E/S material released by the invasive stages of the parasite which in turn modulates their production of pro-inflammatory cytokines. In the absence of the MR, antigen-specific CD4(+) cells are Th1 biased, suggesting that ligation of the MR by glycosylated E/S material released by schistosome larvae modulates the production of CD4(+) cell specific IFNγ.

  13. OGLE-2012-BLG-0455/MOA-2012-BLG-206: Microlensing event with ambiguity in planetary interpretations caused by incomplete coverage of planetary signal

    Energy Technology Data Exchange (ETDEWEB)

    Park, H.; Han, C.; Choi, J.-Y.; Hwang, K.-H.; Jung, Y. K.; Shin, I.-G. [Department of Physics, Institute for Astrophysics, Chungbuk National University, Cheongju 371-763 (Korea, Republic of); Gould, A.; Gaudi, B. S.; Kavka, A.; Pogge, R. W. [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Udalski, A. [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Sumi, T. [Department of Earth and Space Science, Osaka University, Osaka 560-0043 (Japan); Fouqué, P. [IRAP, CNRS, Université de Toulouse, F-31400 Toulouse (France); Christie, G.; Natusch, T.; Ngan, H. [Auckland Observatory, Auckland (New Zealand); Depoy, D. L. [Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States); Dong, Subo [Kavli Institute for Astronomy and Astrophysics, Peking University, Yi He Yuan Road 5, Hai Dian District, Beijing 100871 (China); Lee, C.-U. [Korea Astronomy and Space Science Institute, 776 Daedukdae-ro, Yuseong-gu, Daejeon 305-348 (Korea, Republic of); Monard, L. A. G. [Kleinkaroo Observatory, Calitzdorp, and Bronberg Observatory, Pretoria (South Africa); Collaboration: μFUN Collaboration; OGLE Collaboration; MOA Collaboration; and others

    2014-05-20

    Characterizing a microlensing planet is done by modeling an observed lensing light curve. In this process, it is often confronted that solutions of different lensing parameters result in similar light curves, causing difficulties in uniquely interpreting the lens system, and thus understanding the causes of different types of degeneracy is important. In this work, we show that incomplete coverage of a planetary perturbation can result in degenerate solutions even for events where the planetary signal is detected with a high level of statistical significance. We demonstrate the degeneracy for an actually observed event OGLE-2012-BLG-0455/MOA-2012-BLG-206. The peak of this high-magnification event (A {sub max} ∼ 400) exhibits very strong deviation from a point-lens model with Δχ{sup 2} ≳ 4000 for data sets with a total of 6963 measurements. From detailed modeling of the light curve, we find that the deviation can be explained by four distinct solutions, i.e., two very different sets of solutions, each with a twofold degeneracy. While the twofold (so-called close/wide) degeneracy is well understood, the degeneracy between the radically different solutions is not previously known. The model light curves of this degeneracy differ substantially in the parts that were not covered by observation, indicating that the degeneracy is caused by the incomplete coverage of the perturbation. It is expected that the frequency of the degeneracy introduced in this work will be greatly reduced with the improvement of the current lensing survey and follow-up experiments and the advent of new surveys.

  14. 磷酸奥司他韦预防甲型H1N1流感时引起不良反应206例报道%Report of 206 cases of adverse drug reactions in using oseltamivir to prevent influenza A H1N1 influenza

    Institute of Scientific and Technical Information of China (English)

    董伟; 王艳彩

    2011-01-01

    AIM To analyse the adverse drug reactions (ADRs) occurred in people who took oseltamivir phosphate to prevent influenza A H1N1 influenza. METHODS The ADRs of 2 978 cases who took oseltamivir phosphate 75 mg once daily for 7 d to prevent influenza A H1N1 influenza were recorded every day and 2 790 cases with intact data were carried out statistical analysis. RESULTS There were 206 cases of ADRs, with the total ADRs incidence rate of 7.38%. Cases with the main clinical manifestations of enteron symptoms such as diarrhea, nausea, and bellyache etc.were 157, with the incidence rate of 5.62%. The incidenec rate of ADRs was low in rash, otalgia, tachycardia, foreign body sensation of esophagus and nosebleed and insomnia etc. CONCLUSION The ADRs of oseltamivir phosphate in the prevention of influenza A HIN1 influenza mainly were enteron symptoms which do not affect the treatment in general. But if such symptoms as rash or tachyeardia occur, the drug should be immediately stopped and symptomatic treatment must be given.%目的 分析磷酸奥司他韦预防甲型H1N1流感时人群不良反应发生情况.方法 对2978例服用磷酸奥司他韦75㎎,qd,共7 d预防甲型H1N1型流感者逐日记录其不良反应并将2790例资料完整者进行分析统计.结果 206例出现不良反应,总不良反应发生率为7.38%,以腹泻、恶心、腹痛等消化道症状为主,共157例,发生率为5.62%.皮疹、耳痛、心动过速、食管异物感、鼻出血、失眠等发生率低.结论 磷酸奥司他韦预防甲型H1N1流感时不良反应以消化道症状为主,一般不影响治疗.如出现皮疹、心动过速等应停药并给予对症处理.

  15. 20.6.Cerebrovascular disease

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930388 A study on the activity of three antiox-idant enzymes in the brain of experimental acutecerebral ischemia.BAI Yun (白云),et al.LabNeurochemist,Tianjin Neurol Instit,Tianjin,300052.Chin J Neurol & Psychiat 1992;25 (6):351—354.The activities of superoxide dismutase (SOD),glutathione peroxidase (GSH—Px) and catalase(CAT) in the ischemic cerebral tissue followingthe unilateral middle cerebral artery occlusion ofrats were assessed.In comparison with the sham—operated rats,both SOD and GSH—Px activi-ty in the ischemic area (striatum and temporalcortex) were significantly reduced by 30min ofischemia,GSH—Px activity in the peri-is-

  16. Tertiary and quaternary structures of 0.19 alpha-amylase inhibitor from wheat kernel determined by X-ray analysis at 2.06 A resolution.

    Science.gov (United States)

    Oda, Y; Matsunaga, T; Fukuyama, K; Miyazaki, T; Morimoto, T

    1997-11-04

    The crystal structure of 0.19 alpha-amylase inhibitor (0.19 AI) from wheat kernel was determined by the multiple-isomorphous replacement method coupled with density modification and noncrystallographic symmetry averaging and then refined by simulated annealing using diffraction data to 2.06 A resolution (R = 18.7%, free R = 22.3%). The asymmetric unit has four molecules of 0.19 AI, each comprised of 124 amino acid residues. Electron density for residues 1-4 and 69-77 is absent in all subunits, probably because of the intrinsic flexibility of these segments. Each subunit has four major alpha-helices and one one-turn helix which are arranged in the up-and-down manner, maintaining the favorable packing modes of the alpha-helices. 0.19 AI, however, has two short antiparallel beta-strands. All 10 cysteine residues in 0.19 AI form disulfide bonds (C6-C52, C20-C41, C28-C83, C42-C99, and C54-C115), consistent with the assignments made biochemically for 0.28 AI from wheat kernel and by NMR analysis of the bifunctional alpha-amylase/trypsin inhibitor from ragi seeds (RBI). The disulfide bond patterns in these AIs are similar to those in the hydrophobic protein from soybean (HPS), which lack only the bond corresponding to C28-C83 in 0.19 AI. Extensive interactions occurred between particular pairs of 0.19 AI subunits, mainly involving hydrophobic residues. Comparisons of the structures of 0.19 AI, RBI, and HPS showed that the arrangements of the major alpha-helices are similar but the conformations of the remaining residues differ markedly. The present X-ray analysis for 0.19 AI and the NMR analysis for RBI suggest that all the AIs in this family have a common fold. The alpha-amylase binding site is discussed on the basis of the tertiary and quaternary structures of 0.19 AI together with biochemical and spectroscopic data for AIs.

  17. Improved 206Pb/238U microprobe geochronology by the monitoring of a trace-element-related matrix effect; SHRIMP, ID-TIMS, ELA-ICP-MS and oxygen isotope documentation for a series of zircon standards

    Science.gov (United States)

    Black, L.P.; Kamo, S.L.; Allen, C.M.; Davis, D.W.; Aleinikoff, J.N.; Valley, J.W.; Mundil, R.; Campbell, I.H.; Korsch, R.J.; Williams, I.S.; Foudoulis, C.

    2004-01-01

    Precise isotope dilution-thermal ionisation mass spectrometry (ID-TIMS) documentation is given for two new Palaeozoic zircon standards (TEMORA 2 and R33). These data, in combination with results for previously documented standards (AS3, SL13, QGNG and TEMORA 1), provide the basis for a detailed investigation of inconsistencies in 206Pb/238U ages measured by microprobe. Although these ages are normally consistent between any two standards, their relative age offsets are often different from those established by ID-TIMS. This is true for both sensitive high-resolution ion-microprobe (SHRIMP) and excimer laser ablation-inductively coupled plasma-mass spectrometry (ELA-ICP-MS) dating, although the age offsets are in the opposite sense for the two techniques. Various factors have been investigated for possible correlations with age bias, in an attempt to resolve why the accuracy of the method is worse than the indicated precision. Crystallographic orientation, position on the grain-mount and oxygen isotopic composition are unrelated to the bias. There are, however, striking correlations between the 206Pb/238U age offsets and P, Sm and, most particularly, Nd abundances in the zircons. Although these are not believed to be the primary cause of this apparent matrix effect, they indicate that ionisation of 206Pb/238U is influenced, at least in part, by a combination of trace elements. Nd is sufficiently representative of the controlling trace elements that it provides a quantitative means of correcting for the microprobe age bias. This approach has the potential to reduce age biases associated with different techniques, different instrumentation and different standards within and between laboratories. Crown Copyright ?? 2004 Published by Elsevier B.V. All rights reserved.

  18. 20.6 W Nd∶YVO4 Thin Disk Laser with Laser-Diode Direct Upper-State Pumping%20.6W激光二极管直接上能级抽运Nd∶YVO4薄片激光器

    Institute of Scientific and Technical Information of China (English)

    吴兴盛; 高健存; 唐新春; 王坤; 方茗; 王豫明; 曹有旺

    2012-01-01

    A 880 nm laser diode direct upper-state pumped Nd: YVO4 thin disk laser is demonstrated. With a 0. 3 mm thick Nd-doping concentration of 0. 5% Nd:YVO4 disk and pump power of 39. 3 W, 20. 6 W output power at 1064 nm is obtained and the optical-optical efficiency exceeds 50% .%使用自行搭建的24通抽运系统,实现了880 nm激光器二极管直接上能级抽运的Nd∶YVO4薄片激光器.采用厚度为0.3 mm、掺杂原子数分数为0.5%的Nd∶YVO4薄片晶体,在39.3W的抽运功率下获得了20.6W的1064 nm连续激光输出,光-光转换效率超过50%.

  19. An investigation on the effect of second-order additional thickness distributions to the upper surface of an NACA 64-206 airfoil. [using flow equations and a CDC 7600 digital computer

    Science.gov (United States)

    Merz, A. W.; Hague, D. S.

    1975-01-01

    An investigation was conducted on a CDC 7600 digital computer to determine the effects of additional thickness distributions to the upper surface of an NACA 64-206 airfoil. Additional thickness distributions employed were in the form of two second-order polynomial arcs which have a specified thickness at a given chordwise location. The forward arc disappears at the airfoil leading edge, the aft arc disappears at the airfoil trailing edge. At the juncture of the two arcs, x = x, continuity of slope is maintained. The effect of varying the maximum additional thickness and its chordwise location on airfoil lift coefficient, pitching moment, and pressure distribution was investigated. Results were obtained at a Mach number of 0.2 with an angle-of-attack of 6 degrees on the basic NACA 64-206 airfoil, and all calculations employ the full potential flow equations for two dimensional flow. The relaxation method of Jameson was employed for solution of the potential flow equations.

  20. Introduction of EU No. 626/2011 and EU No. 206/2012%欧盟空调及热泵新能源标签指令及ErP指令介绍

    Institute of Scientific and Technical Information of China (English)

    钟文初

    2013-01-01

    EU No. 626/2011 supplementing Directive 2010/30/EU of the European Parliament and of the Council with regard to energy labelling of air conditioners for air conditioning and heat pump and EU No. 206/2012 implementing Directive 2009/125/EC of the European Parliament and of the Council with regard to ecodesign requirements for air conditioners and comfort fans officially implemented in 2013. These two directives adopted a new assessment methods and concepts for the energy efficiency performance of air conditioning and heat pump. This article focuses on introductions for both directives and provides designer a better understanding of the EU's new requirements for such products.%  欧盟针对空调及热泵产品的新能源标签指令(EU No.626/2011)和ErP指令的实施方法(EU No.206/2012)于2013年1月正式实施。这两个指令采用了新的评估方法和理念对空调及热泵产品进行节能评估。本文着重对这两个指令进行介绍阐述,帮助设计开发人员更好的理解欧盟对于这类产品的新要求。

  1. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Energy Technology Data Exchange (ETDEWEB)

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  2. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Science.gov (United States)

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  3. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Energy Technology Data Exchange (ETDEWEB)

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  4. Performance evaluation of the AVIV 206D Zinc Protoporphyrin Hematof1uorometer and application of ZPP to diagnose%血液荧光测定仪性能评价及其在IDA诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    邸亚男; 潘卫; 徐国宾

    2011-01-01

    Objective To estim ate the perform ance characteristics of the AV Ⅳ 206D Zinc Protoporphyrin (ZPP ) Hem atofluorom eter and to study the distribution of ZPP in healthy people and its diagnostic perform ance in iron deficiency anem ia (IDA ) in hospitalized patients .Methods The with in-day variation and the day-to-day variation were determ ined by AV Ⅳ 206D Zinc Protoporphyrin Hem atofluorom eter;The effects of various storage conditions were investigated by m easuring ZPP in whole venous blood sam ples at fast and after storage atroom tem perature for 24 h ,48 hand 40℃ for 7 d ,14 d ;The whole blood sam pjes of 1908 apparently healthy people and 100 hospitali'zed patients with ID A were analyzed by AV Ⅳ 206D Zinc Protoporphyrin Hem atofluorom eter and sim uhaneously we collected their results of routine analysis of biochem istry and blood .Results The coefficient variances (CV ) of with in-day precision w ere 6 .9% ,9 .4% ,4 .3% and the day-to-day precision were 9 .8% ,5 .4% ,2 .7% in low/medium /high level respectively ;ZPP level did not change significantly when stored at room tem perature for 24 h and 48h and at 4o℃ for 7 days and 14 days;The distribution of ZPP in healthy people was not norm al and itw as significantly different in fem ales and males ( t= 12 .106 . P<0 .0001) ,higher in fem ales;TheRE was also significantly different for ZPP in healthy people and hospitalized patients ( t= 12 .342 . P<0.0001) ;ZPP had significant negative correlations with Hb in both healthy and hospitalized people and the comelation coefficients w ere r=-0 .516 ( P<0 .0001) and 0 .306 ( P<0 .0001) ,respectively ;The area under curve (AUC ) of receiver operating characteristic (ROC ) curves for TIBC /M CV /SI and ZPP are 0 .862 ,0 .812, 0 .750 ,0 .629 respectively .Conclusion The AV Ⅳ 206D Zinc Protoporphrin Hem atofluorom eter has good perform ance and m aybe useful for ID A screening in healthy population ,but there are some interference

  5. Distribution of pathogens and their antibiotic resistance in 206 elderly patients with nosocomial lower respiratory tract infections%206例老年人下呼吸道院内感染的病原菌分布及耐药性调查

    Institute of Scientific and Technical Information of China (English)

    奚菁颖; 童如镜; 宋钟娟; 王璐华; 沈杰; 庞立峰

    2005-01-01

    目的了解老年人院内下呼吸道感染病原菌的分布及耐药状况,为临床合理应用抗菌药物提供参考.方法采用纸片琼脂扩散法(K-B Test),按2000年美国国家临床实验室标准化委员会(NCCLS)药敏试验标准判断结果.结果2002年3月至2003年5月干部病房206例老年院内下呼吸道感染患者的痰液及经气管切开取得的痰液标本培养分离所得病原菌285株,以革兰阴性菌为主,其中非发酵菌中假单胞菌属菌株对第3代头孢菌素耐药率普遍较高(41.18%~93.75%),而对碳青霉烯类耐药率稍低;不动杆菌属对碳青霉烯类、头孢哌酮-舒巴坦、头孢他啶等敏感性较好;大肠埃希菌、克雷伯菌属、肠杆菌属等肠杆菌科细菌对第3代头孢菌素耐药率均很高;除肠杆菌属外其他肠杆菌科细菌对碳青霉烯类均较敏感.结论本院干部病房老年人院内下呼吸道感染主要病原菌为革兰阴性杆菌,其对常用抗菌药物的耐药性呈上升趋势.

  6. Picosecond pulses in deep ultraviolet (257.5 nm and 206 nm) and mid-IR produced by a high-power 100 kHz solid-state thin-disk laser

    Science.gov (United States)

    Turčičová, Hana; Novák, Ondřej; Smrž, Martin; Miura, Taisuke; Endo, Akira; Mocek, TomáÅ.¡

    2016-04-01

    We report on the generation of picosecond deep ultraviolet pulses at 257.5 nm and 206 nm produced as the fourth and fifth harmonic frequencies of the diode-pumped Yb:YAG thin-disk laser at the fundamental wavelength of 1030 nm. We present a proposal for a picosecond pulse mid-IR source tunable between 2 and 3 μm. The laser at the fundamental wavelength is based on a chirped-pulse amplification of pulses of a sub-ps laser oscillator in a regenerative amplifier with a thin-disk active medium. The diode pumping at the zero phonon line is used. The output beam is close to the fundamental spatial mode and the pulses are characterized by a 100 kHz repetition frequency, less than 4 ps pulse duration and Picosecond output pulses tunable between 2 and 3 μm at an average power of 10 W are proposed.

  7. Stable (206Pb, 207Pb, 208Pb) and radioactive (210Pb) lead isotopes in 1 year of growth of Sphagnum moss from four ombrotrophic bogs in southern Germany: Geochemical significance and environmental implications

    Science.gov (United States)

    Shotyk, William; Kempter, Heike; Krachler, Michael; Zaccone, Claudio

    2015-08-01

    The surfaces of Sphagnum carpets were marked with plastic mesh and 1 year later the production of plant matter was harvested in four ombrotrophic bogs from two regions of southern Germany: Upper Bavaria (Oberbayern, OB) and the Northern Black Forest (Nordschwarzwald, NBF). Radioactive, 210Pb was determined in solid samples using ultralow background gamma spectrometry while total Pb concentrations and stable isotopes (206Pb, 207Pb, 208Pb) were determined in acid digests using ICP-SMS. Up to 12 samples (40 × 40 cm) were collected per site, and 6-10 sites investigated per bog. The greatest variations within a given sampling site were in the range 212-532 Bq kg-1 for 210Pb activity, whereas 206Pb/207Pb and 208Pb/206Pb varied less than 1%. The median values of all parameters for the sites (6-10 per bog) were not significantly different. The median activities of 210Pb (Bq kg-1) in the mosses collected from the bogs in NBF (HO = 372 ± 56, n = 55; WI = 342 ± 58, n = 93) were slightly less from those in OB (GS = 394 ± 50, n = 55; KL = 425 ± 58, n = 24). However, the mosses in the NBF bogs exhibited much greater productivity (187-202 g m-2 a-1) compared to those of OB (71-91 g m-2 a-1), and this has a profound impact on the accumulation rates of 210Pb (Bq m-2 a-1), with the bogs in the NBF yielding fluxes (HO = 73 ± 30; WI = 65 ± 20) which are twice those of OB (GS = 29 ± 11; KL = 40 ± 13). Using the air concentrations of 210Pb measured at Schauinsland (SIL) in the southern Black Forest and average annual precipitation, the atmospheric fluxes of 210Pb at SIL (340 Bq m-2 a-1) exceeds the corresponding values obtained from the mosses by a factor of five, providing the first quantitative estimate of the net retention efficiency of 210Pb by Sphagnum. When the 210Pb activities of all moss samples are combined (n = 227), a significant decrease with increasing plant production rate is observed; in contrast, total Pb concentrations show the opposite trend. The contrasting

  8. Endovenous laser plus stab avulsion in the treatment of lower-limb varicose veins%腔内激光联合点式剥脱治疗下肢浅静脉曲张206

    Institute of Scientific and Technical Information of China (English)

    车星; 朱网林; 戴翔; 桑凯

    2013-01-01

    Objective To explore the advantages of endovenous laser plus stab avulsion in the treatment of lower-limb varicose veins. Methods Between July 1, 2010, and June 31, 2012, 206 patients with a total of 267 lower limbs were submitted to EVLT plus a surgical approach. Results The follow-up from 1 month to 25 months showed no recurrence and no clinical symptoms or signs. After treatment, the edema and itching disappeared, the pigmentation reduced, and all the ulcers healed. Conclusion Endovenous laser plus stab avulsion not only ensure the curative effect, but also achieve the purpose of minimally invasive in the treatment of lower-limb varicose veins.%目的 探讨腔内激光联合点式剥脱治疗下肢浅静脉曲张的优势.方法 2010 年7 月至2012 年7月,206 例患者共267 条患肢确诊为下肢浅静脉曲张,采取腔内激光联合手术治疗.结果 术后随访1~25 个月,所有患肢曲张静脉消失,未见复发,肿胀消退,瘙痒消失,色素沉着有所减轻,溃疡均愈合.结论 腔内激光联合手术治疗下肢浅静脉曲张,其在保证疗效的同时,达到了微创的目的.

  9. Altered Activities of Cysteine Desulfurase Variants H104Q, E156Q, D180G,Q183E and K206A Caused by Changes in Pyridoxal Phosphate Binding%半胱氨酸脱硫酶突变体H104Q,E156Q,D180G,Q183E和K206A通过改变对磷酸吡哆醛的结合影响酶活性

    Institute of Scientific and Technical Information of China (English)

    张婷; 李唐; 赵津; 谭国强

    2015-01-01

    大肠杆菌半胱氨酸脱硫酶(cysteine desulfurase,IscS)是一类依赖磷酸吡哆醛(pyridoxal phosphate,PLP)的同质二聚体的酶.IscS能催化游离底物L-半胱氨酸脱硫,生成L-丙氨酸和单质硫.在此催化过程中,可形成与酶结合的半胱氨酸过硫化物中间物,并出现了7种具有不同特征性吸收峰的中间反应物.为了研究PLP的结合及中间反应物的形成及累积,对IscS中与PLP结合相关,及IscS半胱氨酸活性口袋中特定氨基酸残基位点(His104,Glu156,Asp180,Gln183和Lys206)进行定点突变,结果发现:1)IscS突变体H104Q、D180G、Q183E、K206A对PLP的结合能力具有不同程度的减弱,酶的活性明显降低甚至消失,PLP与蛋白结合的特异吸收峰消失,或发生明显偏移并出现新的吸收峰,且这些新出现的吸收峰又与蛋白形成的各种中间反应物的吸收峰一致;2)IscS突变体E156Q的活性增高,PLP与蛋白结合的吸收峰明显增加.这些结果都表明,IscS氨基酸残基可通过影响PLP的结合及质子转移引起催化过程中不同中间反应物的形成及累积,同时提高或降低蛋白的活性.

  10. Geochemistry and 207Pb/ 206Pb zircon ages of granitoids from the southern portion of the Tamboril-Santa Quitéria granitic-migmatitic complex, Ceará Central Domain, Borborema Province (NE Brazil)

    Science.gov (United States)

    de Araujo, Carlos E. G.; Costa, Felipe G.; Pinéo, Tercyo R. G.; Cavalcante, José C.; Moura, Candido A. V.

    2012-02-01

    The Tamboril-Santa Quitéria Complex is an important Neoproterozoic granitic-migmatitic unit from the Ceará Central Domain that developed from ca. 650 to 610 Ma. In general the granitoids range in composition from diorite to granite with predominance (up to 85%) of granitic to monzogranitic composition with biotite as the main mafic AFM phase. Geochemical and 207Pb/ 206Pb evaporation zircon geochronology studies were applied in a group of these abundant monzogranitic rocks from the region of Novo Oriente in the southern portion of the Ceará Central Domain. In this area the granitoids are weakly peraluminous biotite granitoids and deformed biotite granitoids of high-K calc-alkaline and ferroan composition, which we interpreted as primary magmas (segregated diatexites) derived from the partial melting of crustal material. The close temporal relation of this magmatism with local eclogitic and regional high temperature metamorphism in Ceará Central Domain point out to an orogenic setting, arguably emplaced during the collisional stage. Subordinate coeval juvenile mantle incursions are also present. This crustally derived magmatism is the primary product of the continental thickening that resulted from the collision between the rocks represented by the Amazonian-West African craton (São Luiz cratonic fragment) to the northwest and the Paleoproterozoic-Archean basement of the Borborema Province to the southeast along the Transbrasiliano tectonic corridor.

  11. The clinical analysis of persistently pleural drainage with central venous catheterization to treat tuberculous pleuritis%胸腔置管持续引流治疗结核性胸膜炎206例临床分析

    Institute of Scientific and Technical Information of China (English)

    陈欲晓; 孙根辉

    2006-01-01

    目的:探讨胸腔置入中心静脉导管持续引流治疗结核性胸膜炎的临床疗效.方法:将392例结核性胸膜炎患者分为2组:治疗组206例,采用中心静脉导管置入胸腔持续引流胸水;对照组186例,采用常规胸腔穿刺抽胸水.比较2组患者治疗后胸水消失时间及3、7、14 d后胸水吸收率.结果:治疗组胸水消失时间(7±5) d,对照组(17±9) d,有明显差异;治疗组3、7、14 d胸水吸收率均显著高于对照组,差异有统计学意义(P<0.05).结论:胸腔置管持续引流治疗结核性胸膜炎疗效确切,操作简便,值得推广.

  12. Rb-Sr and single - zircon grain 207Pb / 206Pb chronology of the Monesterio granodiorite and related migmatites. Evidence of a Late Cambrian melting event in the Ossa-Morena Zone, Iberian Massif

    Directory of Open Access Journals (Sweden)

    Bea, F.

    1999-04-01

    Full Text Available The Monesterio granodiorite, a small granodioritic body placed in a migmatitic complex in the SW of the Olivenza-Monesterio antiform, is a key plutonic body to understanding the relationships among the magmatism, metamorphism, and deformation in the Ossa-Morena Zone, SW Iberian Massif. We dated the granodiorite with the single zircon stepwise-evaporation 207Pb/206Pb method, and the related migmatization event with the Rb-Sr method on leucosomes. Our results indicate that the Monesterio granodiorite crystallised at 510 ± 7 Ma and its protolith had a component with Upper Proterozoic zircons with a minimum age of 1696 Ma. Leucosomes give a Rb-Sr age of 511 ± 40 Ma (MSWD =1,7 with initial 87Sr/86Sr =0.70914 ± 0.00048. The lower initial 87Sr/86Sr of the granodiorite and its calc-alkaline chemistry precludes it from having derived from the same protolith as the migmatites. The existence of different magmatic bodies in the Ossa-Morena Zone with ages clustering around 500-510 Ma reveals the existence of a significant melting event during the Late Cambrian that involved protoliths with very different geochemical and isotopic signatures.La granodiorita de Monesterio es un pequeño cuerpo emplazado en un complejo migmatítico en el SO del antiforme Olivenza-Monesterio, importante para entender las relaciones entre magmatismo, metamorfismo y deformación en la Zona de Ossa-Morena. Se ha datado la granodiorita por el método de evaporación secuencial de 207Pb/206Pb en cristal único de circón y los leucosomes de las migmatitas circundantes por el método Rb-Sr. Los datos indican una edad de cristalización de la granodiorita de 510 ± 4 Ma y un posible protolito Proterozoico Superior con una edad mínima de ∼1.700 Ma, obtenida a partir de núcleos heredados de los circones analizados. Los leucosomes dan una edad Rb-Sr de 511 ± 40 Ma, con una relación 87Sr/86Sr=0,70914 ± 0,00048. La relación inicial de 87Sr/86Sr en la granodiorita (

  13. 76 FR 13059 - Airworthiness Directives; Bell Helicopter Textron Canada Limited (BHTC) Model 206A, 206B, 206L...

    Science.gov (United States)

    2011-03-10

    ... Federal Regulations is sold by the Superintendent of Documents. #0;Prices of new books are listed in the... departing from the blades during flight due to missing weight screws and that the failure can occur at...

  14. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  15. 44 CFR 206.367 - Loan repayment.

    Science.gov (United States)

    2010-10-01

    ... outstanding cash from the actual date of its disbursement by the Treasury. (2) The interest amount due will be... interest, P=the principal amount disbursed; R=the interest rate of the loan; and, T=the outstanding term in... be added to the unpaid balance of the loan, bear interest at the same rate as the loan, and...

  16. 44 CFR 206.377 - Loan repayment.

    Science.gov (United States)

    2010-10-01

    ... Assistant Administrator for the Disaster Assistance Directorate. Interest will accrue on outstanding cash..., where I = the amount of simple interest, P = the principal amount disbursed; R = the interest rate of... rate as the loan, and be immediately due without demand. (6) In the event of default on this note...

  17. Reference: 206 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ,5-trichlorophenol (TCP). To determine its importance in detoxifying xenobiotics ...oxification as bound-residue formation. Functional importance of the family 1 glucosyltransferase UGT72B1 in

  18. 20 CFR 498.206 - Prehearing conferences.

    Science.gov (United States)

    2010-04-01

    ... definite statement; (3) Stipulations and admissions of fact as to the contents and authenticity of documents and deadlines for challenges, if any, to the authenticity of documents; (4) Whether the...

  19. 44 CFR 206.363 - Eligibility criteria.

    Science.gov (United States)

    2010-10-01

    ... disaster caused a large enough reduction in cash receipts from normal revenue sources, excluding borrowing... requirements; (ii) Whether there is availability of cash or other liquid assets from the prior fiscal year... receipts to debt service); (vi) Ability to obtain financial assistance or needed revenue from State...

  20. 44 CFR 206.373 - Eligibility criteria.

    Science.gov (United States)

    2010-10-01

    ... following disaster-related factors: (i) Whether the disaster caused a large enough reduction in cash receipts from normal revenue sources, excluding borrowing, which affects significantly and adversely the...) Whether there is availability of cash or other liquid assets from the prior fiscal year; (iii)...

  1. 31 CFR 206.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... business. Day means a calendar day unless otherwise specified. Deposit means as a noun, money that is being.../Annuity, Department of Veterans Affairs Compensation/Pension, Central Intelligence Agency Annuity... Government departments and agencies in relation to central accounting, financial reporting, and...

  2. 44 CFR 206.221 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... defined by section 1201 of the Higher Education Act of 1965. (b) Force account means an applicant's own labor forces and equipment. (c) Immediate threat means the threat of additional damage or destruction from an event which can reasonably be expected to occur within five years. (d) Improved property...

  3. 31 CFR 515.206 - Exempt transactions.

    Science.gov (United States)

    2010-07-01

    ... the creation of information or informational materials, and payment of royalties to a designated... data as defined in the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation... this section. Example #2: A Cuban party exports a single master copy of a Cuban motion picture to a...

  4. 12 CFR 206.4 - Credit exposure.

    Science.gov (United States)

    2010-01-01

    ..., board, commission, or establishment of the United States, or any corporation wholly owned, directly or... most recent report of examination or inspection of the bank or an affiliate prepared by either...

  5. 30 CFR 206.151 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT... operations and day-to-day management of a lease, plant, pipeline, or other facility; and (v) Other evidence... leases. BLM means the Bureau of Land Management of the Department of the Interior. Compression means...

  6. 18 CFR 157.206 - Standard conditions.

    Science.gov (United States)

    2010-04-01

    ... a blanket certificate issued under this subpart is subject to the following conditions: (a... authorized by the blanket certificate and shall issue the relevant portions thereof to construction personnel... parts 50-99; (iii) National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.);...

  7. 31 CFR 544.206 - Exempt transactions.

    Science.gov (United States)

    2010-07-01

    ... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION PROLIFERATORS SANCTIONS... enhancement of informational materials, or to the provision of marketing and business consulting...

  8. 9 CFR 205.206 - Farm products.

    Science.gov (United States)

    2010-01-01

    ... (system must specify by name) Barley, corn, hay, oats, sorghum grain, other feed crops (system must...), pomegranates, other noncitrus fruits (system must specify by name) Berries (system must specify by name) Tree... products produced on farms (system must specify by name) Mushrooms, trees, other forest products...

  9. 5 CFR 2606.206 - Fees.

    Science.gov (United States)

    2010-01-01

    ... Privacy Act fee charged in a timely fashion (i.e., within 30 days of the date of the billing). In such...-358 et seq.), including the use of consumer reporting agencies, collection agencies, and offset....

  10. 44 CFR 206.366 - Loan cancellation.

    Science.gov (United States)

    2010-10-01

    ... to: (i) Interest paid on money borrowed to pay amounts FEMA does not advance toward completion of... utilities for mobile homes used to meet disaster temporary housing requirements. (iii) Unreimbursed costs required for police and fire protection and other community services for mobile home parks established...

  11. 24 CFR 206.21 - Interest rate.

    Science.gov (United States)

    2010-04-01

    ... disclosure provisions of 12 CFR part 226 (Truth in Lending) shall constitute full compliance with paragraph (c)(1) of this section. (d) Post-loan disclosure. At least 25 days before any adjustment to...

  12. 30 CFR 206.451 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... to, operations such as flotation, air, water, or heavy media separation; drying; and related handling..., storing, mixing, loading, treatment with substances including chemicals or oils, and other preparation of... the Interior. Net-back method means a method for calculating market value of coal at the lease or...

  13. 30 CFR 206.251 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., water, or heavy media separation; drying; and related handling (or combination thereof). Contract means..., treatment with substances including chemicals or oils, and other preparation of the coal to the extent that..., production, preparation, and handling of lease products. Net-back method means a method for...

  14. 28 CFR 42.206 - Compliance reviews.

    Science.gov (United States)

    2010-07-01

    ... disparity in the delivery of services to the minority and non-minority or male and female communities they... benefits; (3) The number and nature of discrimination complaints filed against a recipient with OJARS or... negotiations prior to the Director of OJARS' determination of compliance or noncompliance. (f) If, within...

  15. 44 CFR 206.117 - Housing assistance.

    Science.gov (United States)

    2010-10-01

    ... his/her designee may authorize the payment of security deposits; however, the owner or occupant must... privately owned access road and privately owned bridge; (vii) Blocking, leveling, and anchoring of a mobile home, and reconnecting or resetting mobile home sewer, water, electrical and fuel lines and tanks;...

  16. 44 CFR 206.342 - Definitions.

    Science.gov (United States)

    2010-10-01

    ..., payment rebate, subsidy or any other form of direct or indirect Federal assistance. (g) New financial... ground, as well as a mobile home. (j) Substantial improvement means any repair, reconstruction or...

  17. 44 CFR 206.376 - Loan cancellation.

    Science.gov (United States)

    2010-10-01

    ... benefits, contractual services, and commodities. Capital expenditures and debt service payments and capital.... (ii) Unreimbursed costs to local governments for providing usable sites with utilities for mobile... and fire protection and other community services for mobile home parks established as the result of...

  18. 44 CFR 206.111 - Definitions.

    Science.gov (United States)

    2010-10-01

    ..., mobile homes and travel trailers. Applicant means an individual or household who has applied for... expected to return during the assistance period. Housing costs means rent and mortgage payments, including... the placement of government or privately owned mobile homes, travel trailers, and other...

  19. 40 CFR 96.206 - Standard requirements.

    Science.gov (United States)

    2010-07-01

    ... requirements of subpart HHH of this part. (2) The emissions measurements recorded and reported in accordance with subpart HHH of this part shall be used to determine compliance by each CAIR SO2 source with the... HHH of this part. (2) A CAIR SO2 unit shall be subject to the requirements under paragraph (c)(1)...

  20. 40 CFR 97.206 - Standard requirements.

    Science.gov (United States)

    2010-07-01

    ... subpart HHH of this part. (2) The emissions measurements recorded and reported in accordance with subpart HHH of this part shall be used to determine compliance by each CAIR SO2 source with the CAIR SO2... the control period from all CAIR SO2 units at the source, as determined in accordance with subpart...

  1. Comment on "207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the Central Anatolian crust, Turkey" - Boztug, D., Tichomirowa, M. & Bombach, K., 2007, JAES 31, 71-86

    Science.gov (United States)

    Göncüoglu, M. Cemal

    A continent-oceanic island arc collision model was proposed as a new geodynamic scenario for the evolution of the Cretaceous Central Anatolian granitoids in the Central Anatolian crystalline complex (CACC) by Boztug et al. (2007b) [Boztug, D., Tichomirowa, M., Bombach, K., 2007b. 207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the central Anatolian crust, Turkey. Journal of Asian Earth Sciences 31, 71-86]. The key aspects of this model include an intra-oceanic subduction in the Neotethyan Izmir-Ankara Ocean, formation of an island arc and its subsequent collision with the northern margin of the Tauride-Anatolide Platform. The identical scenario was initially proposed by Göncüoglu et al. (1992) [Göncüoglu, M.C., Erler, A., Toprak, V., Yalınız, K., Olgun, E., Rojay, B., 1992. Geology of the western Central Anatolian Massif, Part II: Central Areas. TPAO Report No: 3155, 76 p] . Moreover, the weighted mean values of the reported 207Pb-206Pb single-zircon evaporation ages by Boztug et al. (2007b) [Boztug, D., Tichomirowa, M., Bombach, K., 2007b. 207Pb-206Pb single-zircon evaporation ages of some granitoid rocks reveal continent-oceanic island arc collision during the Cretaceous geodynamic evolution of the central Anatolian crust: Turkey. Journal of Asian Earth Sciences 31, 71-86] from A-type granitoids in the CACC seem to be miscalculated and contrast with the field data.

  2. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  3. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  4. Corrigendum to "Observation of Neon at mid and high latitudes in the sunlit Lunar Exosphere: Results from CHACE aboard MIP/Chandrayaan-1", Vol. 272 (2016), pp 206-211, doi 10.1016/j.icarus.2016.02.030

    Science.gov (United States)

    Pratim Das, Tirtha; Thampi, Smitha V.; Bhardwaj, Anil; Ahmed, S. M.; Sridharan, R.

    2017-03-01

    Our paper titled "Observation of Neon at mid and high latitudes in the sunlit Lunar Exosphere: Results from CHACE aboard MIP/Chandrayaan-1" (Icarus 272 (2016) 206-211) presents the results of the observations on the distribution of neutral Neon in the mid and high lunar latitudes by the CHACE instrument aboard Moon Impact Probe (MIP) in Chandrayaan-1. The authors recently noticed two errors in the representation of the results in two figures, although there is no change in the reported number densities and the other interpretations of the results.

  5. Clinical distribution and drug resistance of 3 206 strains of Enterobacteriaceae bacteria%3206株肠杆菌科细菌的临床分布及耐药性分析

    Institute of Scientific and Technical Information of China (English)

    冯丽娜; 李从荣; 潘月华; 杨勇文

    2016-01-01

    目的 了解临床分离肠杆菌科细菌的临床分布及耐药性,为临床合理使用抗菌药物提供理论依据.方法 分析2014年1月至2015年6月武汉大学人民医院分离的肠杆菌科细菌分布特点及药敏结果,分离的所有肠杆菌科细菌均采用全自动细菌鉴定药敏系统BD-Phoenix-100进行鉴定.结果 共检出3 206株肠杆菌科细菌,其中主要为大肠埃希菌1 821株(56.8%)、肺炎克雷伯菌652株(20.4%)、阴沟肠杆菌201株(6.3%)、产气肠杆菌104株(3.2%),肠杆菌科细菌以尿液标本分离率最高(1 666株,52.0%),其次为痰标本(463株,14.4%)和血液标本(343株, 10.7%),科室分布以泌尿外科(599株,18.7%)和肾病内科(380株,11.9%)为主.肠杆菌科细菌敏感性最高的抗菌药物为亚胺培南和美罗培南,尤其是大肠埃希菌和肺炎克雷伯菌,耐药率均低于3.1%,阿米卡星和哌拉西林/他唑巴坦亦保持了良好的抗菌活性.结论 肠杆菌科细菌在泌尿外科和肾病内科分布比较集中,对抗菌药物呈现不同程度的耐药,碳青霉烯类抗生素亚胺培南和美罗培南仍是最敏感的抗肠杆菌科细菌药物,但已有耐药株的出现,临床应采取有效的防控措施从而减少耐药菌株的出现和播散流行.%Objective To analyze the clinical distribution and drug resistance of Enterobacteriaceae bacteria, and to provide theoretical basis for clinical rational use of antimicrobial agents. Methods The clinical distribution and drug susceptibility results of Enterobacteriaceae bacteria isolated from Renmin Hospital of Wuhan University from Janu-ary 2014 to June 2015 were analyzed. All the isolated Enterobacteriaceae bacteria were identified by automatic bacteria identification and drug susceptibility systems BD-Phoenix-100. Results A total of 3 206 strains of Enterobacteriaceae bacteria were detected, mainly including 1 821 strains (56.8%) of E. coli, 652 strains (20.4%) of Klebsiella pneumonia, 201 strains (6.3%) of

  6. SOPHIE velocimetry of Kepler transit candidates. XV. KOI-614b, KOI-206b, and KOI-680b: a massive warm Jupiter orbiting a G0 metallic dwarf and two highly inflated planets with a distant companion around evolved F-type stars

    CERN Document Server

    Almenara, J M; Bouchy, F; Havel, M; Bruno, G; Hébrard, G; Diaz, R F; Deleuil, M; Barros, S C C; Boisse, I; Bonomo, A; Montagnier, G; Santerne, A

    2015-01-01

    We report the validation and characterization of three new transiting exoplanets using SOPHIE radial velocities: KOI-614b, KOI-206b, and KOI-680b. KOI-614b has a mass of $2.86\\pm0.35~{\\rm M_{Jup}}$ and a radius of $1.13^{+0.26}_{-0.18}~{\\rm R_{Jup}}$, and it orbits a G0, metallic ([Fe/H]=$0.35\\pm0.15$) dwarf in 12.9 days. Its mass and radius are familiar and compatible with standard planetary evolution models, so it is one of the few known transiting planets in this mass range to have an orbital period over ten days. With an equilibrium temperature of $T_{eq}=1000 \\pm 45$ K, this places KOI-614b at the transition between what is usually referred to as "hot" and "warm" Jupiters. KOI-206b has a mass of $2.82\\pm 0.52~{\\rm M_{Jup}}$ and a radius of $1.45\\pm0.16~{\\rm R_{Jup}}$, and it orbits a slightly evolved F7-type star in a 5.3-day orbit. It is a massive inflated hot Jupiter that is particularly challenging for planetary models because it requires unusually large amounts of additional dissipated energy in the ...

  7. SOPHIE velocimetry of Kepler transit candidates. XV. KOI-614b, KOI-206b, and KOI-680b: a massive warm Jupiter orbiting a G0 metallic dwarf and two highly inflated planets with a distant companion around evolved F-type stars

    Science.gov (United States)

    Almenara, J. M.; Damiani, C.; Bouchy, F.; Havel, M.; Bruno, G.; Hébrard, G.; Diaz, R. F.; Deleuil, M.; Barros, S. C. C.; Boisse, I.; Bonomo, A. S.; Montagnier, G.; Santerne, A.

    2015-03-01

    We report the validation and characterization of three new transiting exoplanets using SOPHIE radial velocities: KOI-614b, KOI-206b, and KOI-680b. KOI-614b has a mass of 2.86 ± 0.35 MJup and a radius of 1.13 +0.26-0.18 RJup, and it orbits a G0, metallic ([ Fe/H ] = 0.35 ± 0.15) dwarf in 12.9 days. Its mass and radius are familiar and compatible with standard planetary evolution models, so it is one of the few known transiting planets in this mass range to have an orbital period over ten days. With an equilibrium temperature of Teq = 1000 ± 45 K, this places KOI-614b at the transition between what is usually referred to as "hot" and "warm" Jupiters. KOI-206b has a mass of 2.82 ± 0.52 MJup and a radius of 1.45 ± 0.16 RJup, and it orbits a slightly evolved F7-type star in a 5.3-day orbit. It is a massive inflated hot Jupiter that is particularly challenging for planetary models because it requires unusually large amounts of additional dissipated energy in the planet. On the other hand, KOI-680b has a much lower mass of 0.84 ± 0.15 MJup and requires less extra-dissipation to explain its uncommonly large radius of 1.99 ± 0.18 RJup. It is one of the biggest transiting planets characterized so far, and it orbits a subgiant F9-star well on its way to the red giant stage, with an orbital period of 8.6 days. With host stars of masses of 1.46 ± 0.17 M⊙ and 1.54 ± 0.09 M⊙, respectively, KOI-206b, and KOI-680b are interesting objects for theories of formation and survival of short-period planets around stars more massive than the Sun. For those two targets, we also find signs of a possible distant additional companion in the system. Based on observations made with SOPHIE on the 1.93-m telescope at the Observatoire de Haute-Provence (CNRS), France.Figures 11-14 are available in electronic form at http://www.aanda.org

  8. 49 CFR 571.206 - Standard No. 206; Door locks and door retention components.

    Science.gov (United States)

    2010-10-01

    ... can be loaded or unloaded. It does not include: (a) A trunk lid; or (b) A door or window composed... the door in the fully latched or secondary latched position. Trunk Lid is a movable body panel that... minimum displacement of 300 mm. (c) Two load cells of sufficient capacity to measure the applied...

  9. U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar geochronology of granite-greenstone terrains of Gaviao Block: implications for the Proterozoic and Archean evolution of Sao Francisco Craton, Brazil; Geocronologia U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar dos terrenos granito-greenstone do Bloco do Gaviao: implicacoes para a evolucao arqueana e proterozoica do craton do Sao Francisco, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Leal, Luiz Rogerio Bastos

    1998-07-01

    The Gaviao Block (GB) in the northern portion of the Sao Francisco Craton-Northeast of Brazil, constitutes one of the oldest Archean fragments of the South American Platform Archean crust. GB underwent several events of juvenile accretion and reworking of continental crust along its evolutionary history, notably between the Archean and the Paleoproterozoic. {sup 207}Pb/{sup 206}Pb isotopic analyses were carried out in two zircons populations from strongly migmatized TTG terranes found in the proximity of Brumado: the first population (7 crystals) is taken as representative of the crystallization period of the TTG terranes at 3300 {+-} 45 Ma; the second (2 crystals) represents the age of the first even of metamorphism/migmatization at 2910 {+-} 10 Ma. {sup 207} Pb/{sup 206} Pb analyses in zircons from an outcrop of non-migmatized TTG in the area yielded a 3202 {+-} 15 Ma age (4 crystals), interpreted to be the crystallization period of the gneiss protolith. Sm/Nd analyses on the TTG rocks of the Brumado region yielded T{sub DM} model ages varying between 3.26 and 3.36 Ga and {epsilon}{sub Nd}{sup (t)} between -3.5 and +0.7. These data suggest the occurrence of juvenile accretions to the continental crust during the Archean, with differential involvement of crustal materials. The geochemical data of rare earth elements corresponding to the TTG terranes revealed moderate LRRE contents (La{sub N}=83,5), low HREE contents (La{sub N}=2,5) and a fairly fractionated pattern (La/Yb){sub N}=34, besides lack of negative Eu anomaly, showing that these rocks have similar compositions to those TTG terranes of cratonic continents, as well as some Archean rocks from CSF (e.g. Sete Voltas, Boa Vista). Finally, the youngest ages present in GB rocks (ca. 1.2-0.45 Ga) represent the role played by tectono thermal events, which produced partial or total rejuvenation of the Rb/Sr and K/Ar isotopic systems during the Espinhaco and Brasiliano cycles. In particular, K/Ar ages illustrate the

  10. Residual nuclide formation in 206,207,208,nat-Pb and 209-Bi induced by 0.04-2.6 GeV Protons as well as in 56-Fe induced by 0.3-2.6 GeV Protons

    CERN Document Server

    Titarenko, Yu E; Titarenko, A Yu; Butko, M A; Pavlov, K V; Tikhonov, R S; Florya, S N; Mashnik, S G; Ignatyuk, A V; Gudowski, W

    2007-01-01

    5972 independent and cumulative yields of radioactive residuals nuclei have been measured in 55 thin 206,207,208,nat-Pb and 209-Bi targets irradiated by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6, and 2.6 GeV protons. Besides, 219 yields have been measured in 0.3, 0.5, 0.75, 1.0, 1.5, and 2.6 GeV proton-irradiated 56-Fe target. The protons were extracted from the ITEP U-10 synchrotron. The measured data are compared with experimental results obtained elsewhere and with theoretical calculations by LAHET, MCNPX, CEM03, LAQGSM03, CASCADE, CASCADO, and LAHETO codes. The predictive power was found to be different for each of the codes tested, but was satisfactory on the whole in the case of spallation products. At the same time, none of the codes can de-scribe well the product yields throughout the whole product mass range, and all codes must be further improved.

  11. Dicty_cDB: VFM206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nfkmmvf hticyglmlnnvmdvgvi*vttqhlfkkplklpkilvlmlvftvqlvngvkl*vi*vv*v ltygmltmiiih...hsliqafmnlvvglhql*nntlvmemsvvlali*islvlehvqhqlvq vqahhqvhhqvhhqvhhqvqvhhqvqvhhrvhhqvqdqahhhqdq Frame B: flil

  12. 44 CFR 206.370 - Purpose and scope.

    Science.gov (United States)

    2010-10-01

    ..., and the Emergency Supplemental Appropriations Act for Defense, the Global War on Terror, and Hurricane... Emergency Supplemental Appropriations Act for Defense, the Global War on Terror, and Hurricane...

  13. Dicty_cDB: SHH206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mino Acid sequence hci*kiilk*k*k*k*kk*kiypclaiiiylynikinkk*k*INNNNNYNNSNNKMYNFF DRIKAPLSEYKRYAANHKKDDDFTDIED...lated Amino Acid sequence (All Frames) Frame A: hci*kiilk*k*k*k*kk*kiypclaiiiylynikinkk*k*INNNNNYNNSNNKMYNFF

  14. Dicty_cDB: AFI206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available EST320223 tomato radicle, 5 d post-imbibition, Cornell University Lycopersicon esculentum cDNA clone cLEZ19K... AI782264 |AI782264.1 EST263143 tomato susceptible, Cornell Lycopersicon esculentum cDNA clone cLES18L5, mRN

  15. 34 CFR 685.206 - Borrower responsibilities and defenses.

    Science.gov (United States)

    2010-07-01

    ... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION WILLIAM D. FORD FEDERAL DIRECT LOAN PROGRAM Borrower Provisions... eligible to receive assistance under title IV of the Act. (iii) Updating reports to credit bureaus to which the Secretary previously made adverse credit reports with regard to the borrower's Direct Loan....

  16. 44 CFR 206.171 - Crisis counseling assistance and training.

    Science.gov (United States)

    2010-10-01

    ... organizations which are located in or do business primarily in the major disaster area. (f) Immediate services... population, including the types of services to be offered, an estimate of the length of time for which mental... was caused or aggravated by the major disaster or its aftermath; or (ii) He/she may benefit...

  17. Dicty_cDB: VSD206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mino Acid sequence kqdqldllaqvlgegedsgkneileedfdditrgakkskssaptvsrttggstralsggn dmnymeyqapaiyksiptqhalfkqrak...ikllqfikvfqlnmhylnnvlkinnkk*ikk*tkk Frame C: kqdqldllaqvlgegedsgkneileedfdditrgak

  18. 24 CFR 570.206 - Program administrative costs.

    Science.gov (United States)

    2010-04-01

    ... requirements; (iv) Developing interagency agreements and agreements with subrecipients and contractors to carry... occupied by low and moderate income households, or the construction of rental or owner units where at least... development of applications for mortgage and insured loan commitments, including commitment fees, and...

  19. 44 CFR 206.33 - Preliminary damage assessment.

    Science.gov (United States)

    2010-10-01

    ... requesting this support. (b) Damage assessment teams. Damage assessment teams will be composed of at least... possible. Other State and Federal agencies, and voluntary relief organizations may also be asked to... official will brief team members on damage criteria, the kind of information to be collected for...

  20. 31 CFR 206.4 - Collection and payment mechanisms.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Collection and payment mechanisms... payment mechanisms. (a) All funds are to be collected and disbursed by EFT when cost-effective... method for collecting taxes. EFT mechanisms may include ACH credit or debit cards. (3) Salary...

  1. 44 CFR 206.42 - Responsibilities of coordinating officers.

    Science.gov (United States)

    2010-10-01

    ... as necessary to coordinate and monitor assistance programs, disseminate information, accept applications, and counsel individuals, families and businesses concerning available assistance; (3) Coordinate... SCO coordinates State and local disaster assistance efforts with those of the Federal...

  2. 31 CFR 206.6 - Cash management planning and review.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Cash management planning and review... planning and review. (a) An agency shall periodically perform cash management reviews to identify areas...) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE MANAGEMENT OF FEDERAL...

  3. 49 CFR 173.206 - Packaging requirements for chlorosilanes.

    Science.gov (United States)

    2010-10-01

    ... are authorized: Outer packagings: Steel drum: 1A2 Plastic drum: 1H2 Plywood drum: 1D Fiber drum: 1G Steel box: 4A Natural wood box: 4C1 or 4C2 Plywood box: 4D Reconstituted wood box: 4F Fiberboard box:...

  4. Worldwide Report, Nuclear Development and Proliferation, No. 206.

    Science.gov (United States)

    2007-11-02

    explained, "the matter of safeguards has nothing to do with the ^ Argentine position of not signing the Tlatelolco Nuclear Nonproliferation Treaty. He...Energy indicates a complete change in the nuclear supply policy regarding Argentina as a result of the latter’s failure to sign the Tlatelolco

  5. 33 CFR 160.206 - Information required in an NOA.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) PORTS AND WATERWAYS SAFETY PORTS AND WATERWAYS SAFETY-GENERAL Notification of Arrival, Hazardous... CDC (1) Vessel Information: (i) Name; X X X (ii) Name of the registered owner; X X X (iii) Country of... estimated date and time of departure; X X X (vi) The location (port or place and country) or...

  6. 19 CFR 206.34 - Contents of petition.

    Science.gov (United States)

    2010-04-01

    ..., a Canadian or Mexican article, as the case may be, is being imported into the United States in such... the claim that the Canadian or Mexican article concerned is being imported in increased quantities in... facilities in the industry, including data indicating plant closings or the underutilization of...

  7. 44 CFR 206.191 - Duplication of benefits.

    Science.gov (United States)

    2010-10-01

    ... section 312 of the Stafford Act, entitled Duplication of Benefits. This section relates to assistance for...) Duplication when assistance under the Act is involved. If duplication is discovered, the Regional... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Duplication of benefits....

  8. 15 CFR 971.206 - Statement of ownership.

    Science.gov (United States)

    2010-01-01

    ..., including: (i) Whether the citizen is a natural person, partnership, corporation, joint venture, or other... of the association, partnership, or joint venture, including information about the participation and/or ownership of stock of each partner or joint venturer....

  9. 30 CFR 206.461 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... market the production for the mutual benefit of the lessee and the lessor, then MMS shall require that...-per-unit basis, the lessee shall convert whatever consideration is paid to a dollar value equivalent..., overhead, and either depreciation and a return on undepreciated capital investment in accordance...

  10. 32 CFR 206.3 - Overall program emphasis.

    Science.gov (United States)

    2010-07-01

    ... technology, how it is to be developed and applied and how student learning will be impacted. ... promoting international education. (6) Uses of new technologies. During the last decade tremendous advances have been made in the application of new educational technologies. Such technologies have enhanced...

  11. 24 CFR 206.47 - Property standards; repair work.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... back a portion of the contract price attributable to the work done before each interim release of funds, and the total of the hold backs will be released after the final inspection and approval of...

  12. 24 CFR 92.206 - Eligible project costs.

    Science.gov (United States)

    2010-04-01

    ... following: (1) For new construction, costs to meet the applicable new construction standards of the participating jurisdiction and the Model Energy Code referred to in § 92.251; (2) For rehabilitation, costs: (i... construction and rehabilitation of multifamily rental housing, costs to construct or rehabilitate laundry...

  13. Dicty_cDB: AHB206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available complete cds. 103 2e-21 2 BH150585 |BH150585.1 ENTPT01TF Entamoeba histolytica Shear...ed DNA Entamoeba histolytica genomic, DNA sequence. 40 10 1 BH132473 |BH132473.1 ENTON74TF Entamoeba histolytica Shear...ed DNA Entamoeba histolytica genomic, DNA sequence. 40 10 1 AZ549739 |AZ549739.1 ENTFT23TF Entamoeba histolytica Shear...OB90TF Entamoeba histolytica Sheared DNA Entamoeba histolytica genomic, DNA seque...nce. 40 10 1 AZ675565 |AZ675565.1 ENTKR79TR Entamoeba histolytica Sheared DNA Entamoeba histolytica genomic,

  14. 5 CFR 845.206 - Collection by administrative offset.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-DEBT COLLECTION Collection of Overpayment Debts... her designee will determine the cost effectiveness of leaving a claim unresolved for more than 6 years... likelihood of recovering the debt. (2) Salary offset. When the debtor is an employee, or a member of...

  15. 40 CFR 180.206 - Phorate; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... following food commodities: Commodity Parts per million Bean, dry, seed 0.05 Bean, succulent 0.05 Beet, sugar, roots 0.3 Beet, sugar, tops 3.0 Coffee, green bean 1 0.02 Corn, field, forage 0.5 Corn, field... the growing crop, coffee. (b) Section 18 emergency exemptions. (c) Tolerances with...

  16. 19 CFR 206.14 - Contents of petition.

    Science.gov (United States)

    2010-04-01

    ... or market share, a higher and growing inventory (whether maintained by domestic producers, importers... RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE DIVERSION, AND REVIEW OF.... market is the focal point for the diversion of exports of the article concerned by reason of...

  17. Dicty_cDB: VSI206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available adnsgaknlyviavkgikgrlnrlpsagvgdmvm atvkkgkpelrkkvctglvvrqrkhwkrkdgvyiyfednagvmcnpkgevkgnilgpvak ecsdlwpkvatn...D MVMATVKKGKPELRKKVCTGLVVRQRKHWKRKDGVYIYFEDNAGVMCNPKGEVKGNILGP VAKECSDLGQRLPPMPVPLFK*ih Translated Amino Aci...kgrlnrlpsagvgdmvm atvkkgkpelrkkvctglvvrqrkhwkrkdgvyiyfednagvmcnpkgevkgnilgpvak ecsdlwpkvatnagtiv*INTHKVKTIXK...KVCTGLVVRQRKHWKRKDGVYIYFEDNAGVMCNPKGEVKGNILGP VAKECSDLGQRLPPMPVPLFK*ih Homology vs CSM-cDNA Score E Sequence

  18. 7 CFR 20.6 - Submission of reports.

    Science.gov (United States)

    2010-01-01

    ... staff to obtain passwords and access to the Internet reporting site. Exporters also have the option of... these regulations. See § 20.4(i) for definition of a foreign buyer and foreign seller.) (1) Firm A...

  19. 30 CFR 206.157 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... industry and gas customers. GRI fees are allowable provided such fees are mandatory in FERC-approved... or off the lease, for more than 30 days; (2) Aggregator/marketer fees. This includes fees you pay to... arrange marketing or transportation, if such fees are separately identified from aggregator/marketer...

  20. 44 CFR 206.44 - FEMA-State Agreements.

    Science.gov (United States)

    2010-10-01

    ... Agreement imposes binding obligations on FEMA, States, their local governments, and private nonprofit... Households Program. (b) Terms and conditions. This Agreement describes the incident and the incident...

  1. 48 CFR 15.206 - Amending the solicitation.

    Science.gov (United States)

    2010-10-01

    ... the contract file and formalize the notice with an amendment (see subpart 4.5, Electronic Commerce in... (and electronic or facsimile address, if appropriate). (7) Revision to solicitation closing date,...

  2. 19 CFR 206.15 - Institution of investigation.

    Science.gov (United States)

    2010-04-01

    ... report to the President of the results of such previous investigation. (2) Articles subject to prior action. No new investigation will be made under section 202 of the Trade Act with respect to an article...) Articles subject to the Textiles Agreement. No investigation will be made under section 202 of the...

  3. 19 CFR 206.42 - Who may file a petition.

    Science.gov (United States)

    2010-04-01

    ... petition under section 406(a) of the Trade Act may be filed by an entity, including a trade association... threat thereof, to such domestic industry. (b) A petition under section 421(b) or (o) of the Trade Act may be filed by an entity, including a trade association, firm, certified or recognized union,...

  4. 19 CFR 206.62 - Who may file a petition.

    Science.gov (United States)

    2010-04-01

    ... Who may file a petition. A petition for an investigation under section 422(b) of the Trade Act may be filed by an entity, including a trade association, firm, certified or recognized union, or group of... Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS...

  5. 32 CFR 206.5 - Final proposal process.

    Science.gov (United States)

    2010-07-01

    ... problem it addresses, how the proposal addresses issues of national capacity in international education... selection criteria: (1) Importance of the problem. Each proposal will be evaluated according to the merit of... community does the proposal address? How diverse a student population will the proposed program...

  6. 30 CFR 206.259 - Determination of washing allowances.

    Science.gov (United States)

    2010-07-01

    ... either a straight-line depreciation method based on the life of equipment or on the life of the reserves... as a separate line entry on the Form MMS-4430. (2) In conducting reviews and audits, MMS will examine... reporting it as a separate line entry on the Form MMS-4430. When necessary or appropriate, MMS may direct...

  7. 30 CFR 206.57 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... lessee may elect to use either a straight-line depreciation method based on the life of equipment or on... cost allocation method on the basis of the values of the products transported. MMS shall approve the method unless it determines that it is not consistent with the purposes of the regulations in this...

  8. 30 CFR 206.458 - Determination of washing allowances.

    Science.gov (United States)

    2010-07-01

    ... may elect to use either a straight-line depreciation method based on the life of equipment or on the... depreciation and a return on undepreciated capital investment in accordance with paragraph (b)(2)(iv)(A) of... section. After a lessee has elected to use either method for a wash plant, the lessee may not later...

  9. 30 CFR 206.159 - Determination of processing allowances.

    Science.gov (United States)

    2010-07-01

    ... depreciation, the lessee may elect to use either a straight-line depreciation method based on the life of..., including operating and maintenance expenses, overhead, and either depreciation and a return on..., including royalties, are not allowable expenses. (iv) A lessee may use either depreciation or a return...

  10. Dicty_cDB: SHD206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Number of HSP's gapped (non-prelim): 0 length of query: 123 length of database: 80,480,566 effective HSP length: 17 effective... length of query: 106 effective length of database: 78,821,179 effective search space: 8355044974 effective...ve HSP length: 22 effective length of query: 101 effective length of database: 55,795,563,357 effective... search space: 5635351899057 effective search space used: 5635351899057 T: 0 A: 0 X1: 11...r of successful extensions: 0 Number of sequences better than 10.0: 0 length of query: 123 length of database: 56,950,275,839 effecti

  11. 5 CFR 870.206 - Accidental death and dismemberment.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' GROUP LIFE INSURANCE PROGRAM Types and Amount of Insurance § 870..., accidental death benefits are equal to the amount of Option A. (c)(1) Under Basic insurance, accidental... automatic part of Basic and Option A insurance for employees. (2) There is no accidental death...

  12. 42 CFR 431.206 - Informing applicants and recipients.

    Science.gov (United States)

    2010-10-01

    ... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION Fair...; (2) At the time of any action affecting his or her claim; (3) At the time a skilled nursing facility or a nursing facility notifies a resident in accordance with § 483.12 of this chapter that he or...

  13. 5 CFR 551.206 - Administrative exemption criteria.

    Science.gov (United States)

    2010-01-01

    ... performance of office or non-manual work directly related to the management or general business operations, as... have been considered. The term “matters of significance” refers to the level of importance or... in planning long- or short-term organizational objectives; (9) Investigates and resolves matters...

  14. 44 CFR 206.35 - Requests for emergency declarations.

    Science.gov (United States)

    2010-10-01

    ..., which would not qualify under the definition of a major disaster, the Governor of a State, or the Acting... lives and to protect property, public health and safety, or to lessen or avert the threat of a...

  15. 76 FR 12274 - Special Conditions: Bell Helicopter Textron Canada Limited Model 206B and 206L Series Helicopters...

    Science.gov (United States)

    2011-03-07

    ... Society of Automotive Engineers (SAE) document Aerospace Recommended Practice (ARP) 4761 (Guidelines and... Rotorcraft) and Society of Automotive Engineers (SAE) document Aerospace Recommended Practice (ARP) 4761... document between 8:30 a.m. and 4 p.m., Monday through Friday, except Federal holidays. We will consider...

  16. 76 FR 72240 - Twenty-Seventh Meeting: RTCA Special Committee 206: Aeronautical Information and Meteorological...

    Science.gov (United States)

    2011-11-22

    .../Roadmap--SG3 Chairmen Discuss Proposed TOR Changes Final Review and Comment (FRAC): Operational Services... dates Approve proposed TOR changes Decision to release the ConUse document for FRAC process Decision...

  17. 76 FR 54526 - 26th Meeting: RTCA Special Committee 206: Aeronautical Information and Meteorological Data Link

    Science.gov (United States)

    2011-09-01

    ... Deliverables in TOR and potential changes. Discuss the certification and liability issues surrounding the use... Dates. Discuss Status of Deliverables in TOR and potential changes. Decision to release DO-267A...

  18. 77 FR 3030 - Twenty-Eighth Meeting: RTCA Special Committee 206: Aeronautical Information and Meteorological...

    Science.gov (United States)

    2012-01-20

    ... proposed TOR changes ConUse Review February 7, 2012 ConUse Review February 8, 2012 SG1, SG2, and SG3... presentation selection process Approve advisory and normal definitions Approve proposed TOR changes and new...

  19. 77 FR 20688 - 29th Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

    Science.gov (United States)

    2012-04-05

    ... Status. Discuss previously proposed TOR changes and DO-252 Revision. Discuss TOR changes for the June PMC... release to the PMC. Agree upon TOR changes for June PMC meeting. Other business. Adjourn--1...

  20. 29 CFR 779.206 - What are “related activities.”

    Science.gov (United States)

    2010-07-01

    ... AS APPLIED TO RETAILERS OF GOODS OR SERVICES Employment to Which the Act May Apply; Enterprise... retail or service stores in a chain, or departments of an establishment operated through leasing... common business purpose of the enterprise. The Senate Report on the 1966 amendments makes it plain...

  1. 44 CFR 206.120 - State administration of other needs assistance.

    Science.gov (United States)

    2010-10-01

    ... identifies the position, salary and percent of time for each staff person assigned to program administration... disaster declaration before IHP assistance may be provided. FEMA will work with the State to approve the..., resolve negative audit findings, and submit final reports within 90 days of the end of the period...

  2. 42 CFR 447.206 - Cost limit for providers operated by units of government.

    Science.gov (United States)

    2010-10-01

    ... are limited to reimbursement not in excess of the individual health care provider's cost of providing..., each provider must submit annually a cost report to the Medicaid agency that reflects the individual... to the filed cost report for the spending year in which interim payment rates were made. (3)...

  3. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (206-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  4. 30 CFR 206.351 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-07-01

    ... Federal geothermal leases. Byproducts means minerals (exclusive of oil, hydrocarbon gas, and helium... extraction and production would be too difficult. Byproduct recovery facility means a facility where...., an essential part of) the public purpose. Public safety or welfare means a program carried out...

  5. 7 CFR 330.206 - Permits for plant pest movement associated with National Defense projects.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Permits for plant pest movement associated with... (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FEDERAL PLANT PEST REGULATIONS; GENERAL; PLANT PESTS; SOIL, STONE, AND QUARRY PRODUCTS; GARBAGE Movement of Plant Pests §...

  6. 12 CFR 303.206 - Application for payment of principal or interest on subordinated debt.

    Science.gov (United States)

    2010-01-01

    ... explanation of action taken under section 38(h)(3)(A)(ii) of the FDI Act (action other than receivership or... the FDI Act (12 U.S.C. 1831o). Existing approvals pursuant to requests filed under section 18(i)(1) of the FDI Act (12 U.S.C. 1828(i)(1)) (capital stock reductions or retirements) shall not be deemed to...

  7. 31 CFR 598.206 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ..., such as currency, bank deposits, or liquidated financial obligations, subject to § 598.202 shall hold... federally-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at... holder of blocked tangible property, such as chattels or real estate, or of other blocked property,...

  8. P206-M Understanding the Metabolism of Amyloid-Beta in Humans

    OpenAIRE

    2007-01-01

    The most common form of dementia is Alzheimer’s disease. According to the amyloid hypothesis, the disease is preceded by an accumulation of the amyloid-β (Aβ) protein, which leads to downstream events including activation of microglia, inflammation, synaptic dysfunction, and neuronal loss. The objective of this research is to address the physiology of Aβ in humans by measuring its in vivo metabolic rates.

  9. 31 CFR 500.206 - Exemption of information and informational materials.

    Science.gov (United States)

    2010-07-01

    ... market, produce or co-produce, create or assist in the creation of information or informational materials... Regulations, 15 CFR parts 768-799, or to the exportation of goods for use in the transmission of any data. The... permissible transactions under this section. Example #2: A Vietnamese party exports a single master copy of...

  10. 44 CFR 206.12 - Use and coordination of relief organizations.

    Science.gov (United States)

    2010-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE General... facilities of the American National Red Cross, the Salvation Army, the Mennonite Disaster Service, and other voluntary organizations in the distribution of medicine, food, supplies, or other items, and in...

  11. 7 CFR 205.206 - Crop pest, weed, and disease management practice standard.

    Science.gov (United States)

    2010-01-01

    ... problems may be controlled through: (1) Mulching with fully biodegradable materials; (2) Mowing; (3...) Plastic or other synthetic mulches: Provided, That, they are removed from the field at the end of...

  12. 44 CFR 206.181 - Use of gifts and bequests for disaster assistance purposes.

    Science.gov (United States)

    2010-10-01

    ... programs, provision of special ramps, or hospital or home visiting services. The funds may be provided to... grounds of race, color, religion, national origin, sex, age, or economic status. (8) Funds awarded to...

  13. 24 CFR 206.304 - Eligibility for placement on the HECM Counselor Roster.

    Science.gov (United States)

    2010-04-01

    ... is supported by technology that enables HUD to track the results of the counseling offered to each... the HECM counselor: (1) Is employed by a HUD-approved housing counseling agency or an affiliate of a... counseling exam administered by HUD, or a party selected by HUD, within the last 3 years. In order...

  14. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (206-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  15. MO-AB-206-02: Testing Gamma Cameras Based On TG177 WG Report.

    Science.gov (United States)

    Halama, J

    2016-06-01

    This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described.

  16. 44 CFR 206.6 - Donation or loan of Federal equipment and supplies.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Donation or loan of Federal... Donation or loan of Federal equipment and supplies. (a) In any major disaster or emergency, the... governments for use and distribution by them for the purposes of the Stafford Act. (b) A donation or loan...

  17. 48 CFR 206.302-5 - Authorized or required by statute.

    Science.gov (United States)

    2010-10-01

    .... 2424, soft drinks manufactured in the United States are brand name carbonated sodas, manufactured in... universities for the performance of research and development, or for the construction of any research or...

  18. Navy's land and water use assessment : Section 206©- Public Law 101-618

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This note is about an Environmental Assessment in which the Naval Air Station in Fallon, NV proposes an agricultural leasing program for Navy lands to reduce soil...

  19. 42 CFR 3.206 - Confidentiality of patient safety work product.

    Science.gov (United States)

    2010-10-01

    ... are removed: (1) Names; (2) Postal address information, other than town or city, State and zip code... prints; and (13) Full face photographic images and any comparable images; and (B) With respect to...

  20. 50 CFR 223.206 - Exceptions to prohibitions relating to sea turtles.

    Science.gov (United States)

    2010-10-01

    ... to prohibitions relating to sea turtles. (a) Permits—(1) Scientific research, education, zoological... zoological exhibition, or to enhance the propagation or survival of threatened species of sea turtles, in... of sea turtle is found injured, dead, or stranded, any agent or employee of the National...

  1. 17 CFR 275.206(3)-2 - Agency cross transactions for advisory clients.

    Science.gov (United States)

    2010-04-01

    ..., receive commissions from, and have a potentially conflicting division of loyalties and responsibilities... of such other remuneration will be furnished upon written request of such customer; (3)...

  2. 30 CFR 206.178 - How do I determine a transportation allowance?

    Science.gov (United States)

    2010-07-01

    ... otherwise have breached your duty to the lessor to market the production for the mutual benefit of you and... production in a storage facility, whether on or off the lease, for more than 30 days. (2)...

  3. The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206)

    DEFF Research Database (Denmark)

    Andersen, Morten N; Andersen, Niels F; Rødgaard-Hansen, Sidsel;

    2015-01-01

    Tumor-associated macrophages (TAMs) play an important role in the pathophysiology of human malignancies. They support growth of cancer cells by promoting angiogenesis, and by inhibiting tumour cell apoptosis and anti-tumor immune reactions. Several membrane proteins are well-described markers of ...

  4. 77 FR 58210 - 31st Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

    Science.gov (United States)

    2012-09-19

    ... open to the interested public but limited to space availability. With the approval of the chairman... Meteorological Data Link Services. SUMMARY: The FAA is issuing this notice to advise the public of the thirty... review Sub-Group (SG1--Wake OSED, SG3--Architecture, SG4--DO-252 revision, SG5/6--MOPS/MAPS) status...

  5. 78 FR 20167 - 33rd Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

    Science.gov (United States)

    2013-04-03

    ... Other business ] Adjourn Attendance is open to the interested public but limited to space availability... Meteorological Data Link Services. SUMMARY: The FAA is issuing this notice to advise the public of the thirty... necessary daily EDR Turbulence Standards Project Briefing from FAA SE2020 Team SG6 WG1 Architecture...

  6. 78 FR 69928 - 35th Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

    Science.gov (United States)

    2013-11-21

    ... the interested public but limited to space availability. With the approval of the chairman, members of... Meteorological Data Link Services. SUMMARY: The FAA is issuing this notice to advise the public of the thirty... (EDR) Turbulence Project Plenary--SG3 Architecture Document FRAC Resolution 11 December...

  7. 78 FR 51808 - 34th Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

    Science.gov (United States)

    2013-08-21

    ... limited to space availability. With the approval of the chairman, members of the public may present oral... Meteorological Data Link Services. SUMMARY: The FAA is issuing this notice to advise the public of the thirty...: Open session on wake progress (1:00 PM) Thursday--AIS and MET Delivery Architecture...

  8. WE-AB-206-01: Diagnostic Ultrasound Imaging Quality Assurance.

    Science.gov (United States)

    Zagzebski, J

    2016-06-01

    The involvement of medical physicists in diagnostic ultrasound imaging service is increasing due to QC and accreditation requirements. The goal of this ultrasound hands-on workshop is to demonstrate quality control (QC) testing in diagnostic ultrasound and to provide updates in ACR ultrasound accreditation requirements. The first half of this workshop will include two presentations reviewing diagnostic ultrasound QA/QC and ACR ultrasound accreditation requirements. The second half of the workshop will include live demonstrations of basic QC tests. An array of ultrasound testing phantoms and ultrasound scanners will be available for attendees to learn diagnostic ultrasound QC in a hands-on environment with live demonstrations and on-site instructors. The targeted attendees are medical physicists in diagnostic imaging.

  9. 30 CFR 206.180 - How do I determine an actual processing allowance?

    Science.gov (United States)

    2010-07-01

    ... maintenance expenses, overhead, and either depreciation and a return on undepreciated capital investment (in... allowable expenses. (iv) You may use either depreciation with a return on undepreciable capital investment or a return on depreciable capital investment. After you elect to use either method for a...

  10. 30 CFR 206.354 - How do I determine generating deductions?

    Science.gov (United States)

    2010-07-01

    ...) Depreciation under paragraphs (g) and (h) of this section and a return on undepreciated capital investment under paragraphs (g) and (i) of this section; or (iv) A return on capital investment in the power plant... allowable expenses. (g) To compute costs associated with capital investment, a lessee may use...

  11. 30 CFR 206.353 - How do I determine transmission deductions?

    Science.gov (United States)

    2010-07-01

    ...) Depreciation under paragraphs (g) and (h) of this section and a return on undepreciated capital investment under paragraphs (g) and (i) of this section or (iv) A return on the capital investment in the..., are not allowable expenses. (g) To compute costs associated with capital investment, a lessee may...

  12. 30 CFR 206.359 - How do I determine byproduct transportation allowances?

    Science.gov (United States)

    2010-07-01

    ... section and a return on undepreciated capital investment under paragraphs (g) and (i) of this section; or (4) A return on capital investment in the transportation system under paragraphs (g) and (j) of this... compute costs associated with capital investment, a lessee may use either paragraphs (h) and (i)...

  13. SU-E-J-206: Adaptive Radiotherapy for Gynecological Malignancies with MRIGuided Cobolt-60 Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lamb, J; Kamrava, M; Agazaryan, N; Cao, M; Low, D; Thomas, D; Yang, Y [UCLA School of Medicine, Los Angeles, CA (United States)

    2015-06-15

    Purpose: Even in the IMRT era, bowel toxicity and bone marrow irradiation remain concerns with pelvic irradiation. We examine the potential gain from an adaptive radiotherapy workflow for post-operative gynecological patients treated to pelvic targets including lymph nodes using MRI-guided Co-60 radiation therapy. Methods: An adaptive workflow was developed with the intent of minimizing time overhead of adaptive planning. A pilot study was performed using retrospectively analyzed images from one patient’s treatment. The patient’s treated plan was created using conventional PTV margins. Adaptive treatment was simulated on the patient’s first three fractions. The daily PTV was created by removing non-target tissue, including bone, muscle and bowel, from the initial PTV based on the daily MRI. The number of beams, beam angles, and optimization parameters were kept constant, and the plan was re-optimized. Normal tissue contours were not adjusted for the re-optimization, but were adjusted for evaluation of plan quality. Plan quality was evaluated based on PTV coverage and normal tissue DVH points per treatment protocol. Bowel was contoured as the entire bowel bag per protocol at our institution. Pelvic bone marrow was contoured per RTOG protocol 1203. Results: For the clinically treated plan, the volume of bowel receiving 45 Gy was 380 cc, 53% of the rectum received 30 Gy, 35% of the bladder received 45 Gy, and 28% of the pelvic bone marrow received 40 Gy. For the adaptive plans, the volume of bowel receiving 45 Gy was 175–201 cc, 55–62% of the rectum received 30 Gy, 21– 27% of the bladder received 45 Gy, and 13–17% of the pelvic bone marrow received 40 Gy. Conclusion: Adaptive planning led to a large reduction of bowel and bone marrow dose in this pilot study. Further study of on-line adaptive techniques for the radiotherapy of pelvic lymph nodes is warranted. Dr. Low is a member of the scientific advisory board of ViewRay, Inc.

  14. 19 CFR 206.3 - Institution of investigations; publication of notice; and availability for public inspection.

    Science.gov (United States)

    2010-04-01

    ... INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL... imported article that is the subject of the investigation and its tariff subheading, the nature and timing... Commission motion available for public inspection (with the exception of confidential business information)....

  15. 32 CFR 206.1 - Major characteristics of the NSEP institutional grants program.

    Science.gov (United States)

    2010-07-01

    ... SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS NATIONAL SECURITY EDUCATION PROGRAM (NSEP) GRANTS TO... issues of national capacity; and (3) Defines innovative approaches to issues not addressed by NSEP... base capacity currently exists in some foreign languages and area studies. It also recognizes...

  16. 24 CFR 960.206 - Waiting list: Local preferences in admission to public housing program.

    Science.gov (United States)

    2010-04-01

    ... otherwise denying admission to the program based on the race, color, ethnic origin, gender, religion... a preference for persons with a specific disability. (4) Preference for victims of domestic violence... victims of domestic violence. (5) Preference for single persons who are elderly, displaced, homeless or...

  17. 27 CFR 70.206 - Discharge of liens; redemption by United States.

    Science.gov (United States)

    2010-04-01

    ... this section, shall constitute prima facie evidence of the regularity of the redemption. When a... include the amount of the obligation secured by such lien to the extent legally satisfied by reason of the... obligation secured by such lien to the extent legally satisfied by reason of the sale and (B) Any...

  18. 20 CFR 802.206 - Effect of motion for reconsideration on time for appeal.

    Science.gov (United States)

    2010-04-01

    ... appeal. (b)(1) In a case involving a claim filed under the Longshore and Harbor Workers' Compensation Act... title IV of the Federal Mine Safety and Health Act, as amended (see § 802.101(b)(6)), a timely motion... subsequent to the filing of the timely motion for reconsideration, shall be dismissed without prejudice...

  19. 29 CFR 778.206 - Premiums for work outside basic workday or workweek-examples.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION Payments That May Be Excluded From the âRegular Rateâ Extra Compensation Paid for... regular workday or workweek. The extra compensation provided by such premium rates will be excluded...

  20. 30 CFR 206.104 - What publications are acceptable to MMS?

    Science.gov (United States)

    2010-07-01

    ... buyers and sellers frequently use; (2) Publications frequently mentioned in purchase or sales contracts... daily surveys of buyers and sellers of crude oil, and, for ANS spot prices, buyers and sellers of...

  1. 34 CFR 206.3 - Who is eligible to participate in a project?

    Science.gov (United States)

    2010-07-01

    ... secondary school diploma or its equivalent; (2) Not be currently enrolled in an elementary or secondary... school diploma and to gain employment or be placed in an IHE or other postsecondary education or training... 34 Education 1 2010-07-01 2010-07-01 false Who is eligible to participate in a project?...

  2. 34 CFR 206.5 - What definitions apply to these programs?

    Science.gov (United States)

    2010-07-01

    ... Elementary school EDGAR Facilities Minor remodeling Nonprofit Private Project Public Secondary school... in a State; (ii) Is authorized by that State to provide a program of education beyond secondary...: (A) Has a secondary school diploma; (B) Has the recognized equivalent of a secondary school...

  3. 1 CFR 20.6 - Form, style, arrangement and apportionment of space.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Form, style, arrangement and apportionment of... Form, style, arrangement and apportionment of space. The form, style, and arrangement of agency... determined by the Director of the Federal Register. The U.S. Government Printing Office Style Manual is...

  4. 浅析G206国道景德镇段白改黑路面改造设计与施工%Design and Construction of Pavement Asphalt Transformation in Jingdezhen Section of G206 National Highway

    Institute of Scientific and Technical Information of China (English)

    程曦; 施璐

    2014-01-01

    This paper combines with an example to analyze the importance of the design and construction of pavement asphalt transformation by rubblization in old cement pavement.%本文结合实例浅析老水泥路面采用碎石化进行白改黑改造设计与施工的要点。

  5. SU-E-T-206: Improving Radiotherapy Toxicity Based On Artificial Neural Network (ANN) for Head and Neck Cancer Patients

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Daniel D; Wernicke, A Gabriella; Nori, Dattatreyudu; Chao, KSC; Parashar, Bhupesh; Chang, Jenghwa [Weill Cornell Medical College, NY, NY (United States)

    2014-06-01

    Purpose/Objective(s): The aim of this study is to build the estimator of toxicity using artificial neural network (ANN) for head and neck cancer patients Materials/Methods: An ANN can combine variables into a predictive model during training and considered all possible correlations of variables. We constructed an ANN based on the data from 73 patients with advanced H and N cancer treated with external beam radiotherapy and/or chemotherapy at our institution. For the toxicity estimator we defined input data including age, sex, site, stage, pathology, status of chemo, technique of external beam radiation therapy (EBRT), length of treatment, dose of EBRT, status of post operation, length of follow-up, the status of local recurrences and distant metastasis. These data were digitized based on the significance and fed to the ANN as input nodes. We used 20 hidden nodes (for the 13 input nodes) to take care of the correlations of input nodes. For training ANN, we divided data into three subsets such as training set, validation set and test set. Finally, we built the estimator for the toxicity from ANN output. Results: We used 13 input variables including the status of local recurrences and distant metastasis and 20 hidden nodes for correlations. 59 patients for training set, 7 patients for validation set and 7 patients for test set and fed the inputs to Matlab neural network fitting tool. We trained the data within 15% of errors of outcome. In the end we have the toxicity estimation with 74% of accuracy. Conclusion: We proved in principle that ANN can be a very useful tool for predicting the RT outcomes for high risk H and N patients. Currently we are improving the results using cross validation.

  6. 44 CFR 206.131 - Individual and Family Grant Program for major disasters declared on or before October 14, 2002.

    Science.gov (United States)

    2010-10-01

    ... reflect changes in the Consumer Price Index for all Urban Consumers. IFG assistance for damages or losses... services which may generally be characterized as nonessential, luxury, or decorative. Assistance under...

  7. Oahu Hyperspectral Imagery 2000 (206-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  8. Oahu Hyperspectral Imagery 2000 (206-0613-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  9. 44 CFR 206.101 - Temporary housing assistance for emergencies and major disasters declared on or before October 14...

    Science.gov (United States)

    2010-10-01

    ... essential to normal living, i.e., kitchen, one bathroom, dining area, living room, entrances and exits, and..., which shall take all actions necessary to carry out the decision or refrain from any actions prohibited... necessary to carry out their responsibilities under the Act and these regulations. (p)...

  10. Dosimetric investigations of cosmic radiation aboard the Kosmos-936 AES (joint Soviet-American experiment K-206)

    Science.gov (United States)

    Benton, E. V.; Kovalyev, Y. Y.; Dudkin, V. Y.

    1980-01-01

    The Soviet and American parts of the experiment are described separately. Particular attention was given to the following problems: placement of the detectors; study of neutron radiation within the biosatellite; and studies of fragmentation of heavy nuclei on accelerators. Unified methods were developed for the calibration of Soviet and American detectors.

  11. 17 CFR 275.206(4)-2 - Custody of funds or securities of clients by investment advisers.

    Science.gov (United States)

    2010-04-01

    ... management or policies of a person, whether through ownership of securities, by contract, or otherwise...; and (iii) Does not have, and has not had within the past two years, a material business relationship... in customer accounts; (iii) A futures commission merchant registered under section 4f(a) of...

  12. AB206. Combined detrusor-trigone BTX-A injections for urinary incontinence secondary to neurogenic detrusor overactivity

    Science.gov (United States)

    Chen, Hui; Xie, Keji; Jiang, Chonghe; Tang, Ping; Ou, Rubiao; Zeng, Jianweng; Deng, Xiangrong; Zhou, Liling; Huang, Maping; Li, Qingqing; Liu, Qiuling; Huang, Jiebing; Huang, Tanghai

    2016-01-01

    Objective To evaluate the effect and safety of trigonal injection of botulinum toxin A (BTX-A) for patients with neurological detrusor overactivity (NDO) with incontinence. Methods A prospective, multicenter, single-blind and randomized controlled trial (RCT) was conducted between June 2011 and June 2014. Spinal cord injury patients with urinary incontinence secondary to NDO were recruited. At a 1:1 ratio, patients randomly received 200 U BTX-A intradetrusor injections excluding the trigone (control group) or 160 U intradetrusor and 40 U intratrigonal injections (experimental group). Patients were evaluated at baseline, and 4, 12 weeks after injection. The efficacy and safety outcomes included I-QoL, voiding volume, urinary incontinence episodes, complete dryness, maximum detrusor pressure (Pdetmax), volume at first involuntary detrusor contraction (VFIDC). Vesicoureteral reflux (VUR) and other adverse events were recorded. Results Ninety-six patients were recruited and 91 of them completed the trial. Among the 91 patients, 47 were randomized to experimental group and 44 to the control group. There were no significant differences in baseline evaluation items (gender, age, duration of spinal cord injury, level of neurological injury, AIS scores) between the two groups. At 12 weeks, the improvement was significantly better in the experimental group than in the control group for I-QoL (26.01 vs. 18.75, P=0.01), mean urinary incontinence episodes (−5.22/d vs. −4.68/d, P=0.01), complete dryness (13 vs. 5, P=0.03), mean voiding volume (159.72 vs. 139.07 mL, P=0.02), Pdetmax (−33.34 vs. −28.02 cmH2O, P=0.04), and VFIDC (106.81 vs. 97.86 mL, P=0.02), duration of first detrusor contraction (−41.54 vs. −18.65 s, P=0.03) and the number of patients with detrusor contraction (−20 vs. −9, P=0.02). In both of two groups, no patients developed VUR. Conclusions BTX-A intradetrusor and intratrigonal injections are more effective than those excluding the trigone for patients with NDO with incontinence. Intratrigonal injections do not induce VUR.

  13. 19 CFR 206.43 - Contents of a petition under section 406(a) of the Trade Act.

    Science.gov (United States)

    2010-04-01

    ... material injury, data relating to: (i) A decline in sales or market share, a higher and growing inventory... NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE DIVERSION, AND REVIEW OF RELIEF ACTIONS Investigations for Relief From Market...

  14. Dynamic Acquisition and Retrieval Tool (DART) for Comet Sample Return : Session: 2.06.Robotic Mobility and Sample Acquisition Systems

    Science.gov (United States)

    Badescu, Mircea; Bonitz, Robert; Kulczycki, Erick; Aisen, Norman; Dandino, Charles M.; Cantrell, Brett S.; Gallagher, William; Shevin, Jesse; Ganino, Anthony; Haddad, Nicolas; Walkemeyer, Phillip; Backes, Paul; Shiraishi, Lori

    2013-01-01

    The 2011 Decadal Survey for planetary science released by the National Research Council of the National Academies identified Comet Surface Sample Return (CSSR) as one of five high priority potential New Frontiers-class missions in the next decade. The main objectives of the research described in this publication are: develop a concept for an end-to-end system for collecting and storing a comet sample to be returned to Earth; design, fabricate and test a prototype Dynamic Acquisition and Retrieval Tool (DART) capable of collecting 500 cc sample in a canister and eject the canister with a predetermined speed; identify a set of simulants with physical properties at room temperature that suitably match the physical properties of the comet surface as it would be sampled. We propose the use of a dart that would be launched from the spacecraft to impact and penetrate the comet surface. After collecting the sample, the sample canister would be ejected at a speed greater than the comet's escape velocity and captured by the spacecraft, packaged into a return capsule and returned to Earth. The dart would be composed of an inner tube or sample canister, an outer tube, a decelerator, a means of capturing and retaining the sample, and a mechanism to eject the canister with the sample for later rendezvous with the spacecraft. One of the significant unknowns is the physical properties of the comet surface. Based on new findings from the recent Deep Impact comet encounter mission, we have limited our search of solutions for sampling materials to materials with 10 to 100 kPa shear strength in loose or consolidated form. As the possible range of values for the comet surface temperature is also significantly different than room temperature and testing at conditions other than the room temperature can become resource intensive, we sought sample simulants with physical properties at room temperature similar to the expected physical properties of the comet surface material. The chosen DART configuration, the efforts to identify a test simulant and the properties of these simulants, and the results of the preliminary testing will be described in this paper.

  15. 44 CFR 206.48 - Factors considered when evaluating a Governor's request for a major disaster declaration.

    Science.gov (United States)

    2010-10-01

    ... the State. We use a figure of $1 per capita as an indicator that the disaster is of such size that it might warrant Federal assistance, and adjust this figure annually based on the Consumer Price Index for all Urban Consumers. We are establishing a minimum threshold of $1 million in public...

  16. 7 CFR 1710.206 - Approval requirements for load forecasts prepared pursuant to approved load forecast work plans.

    Science.gov (United States)

    2010-01-01

    ... forecast. Examples of internal uses include providing information for developing or monitoring demand side management programs, supply resource planning, load flow studies, wholesale power marketing, retail...

  17. Addendum to “Large negative Goos Hanchen shift at metal surfaces”, [Opt. Comm. 276 (2007) 206

    Science.gov (United States)

    Leung, P. T.; Chen, C. W.; Chiang, H.-P.

    2008-03-01

    In the above communication, we have investigated in details the possibility of observing a large negative lateral Goos-Hanchen (GH) shift from p-polarized light at long wavelength incident onto a bare metal surface, at angles close to grazing incidence. The shift could be up to a few wavelength (e.g. ∼20 μm at a wavelength of 3390 nm onto silver) and the possible presence of a "pseudo Brewster angle" will not hinder the observability of such an effect. This effect has since been verified experimentally via reflection of IR light from a gold surface [1].

  18. 75 FR 51033 - BE Louisiana, LLC; Notice of Institution of Section 206 Proceeding and Refund Effective Date

    Science.gov (United States)

    2010-08-18

    ... USC 824e, to determine whether the J.P. Morgan Sellers' \\1\\ market-based rate authority in the Cleco... (2010). \\1\\ For purposes of this notice, the J.P. Morgan Sellers are BE Louisiana, LLC, Cedar Brakes...

  19. 44 CFR 206.209 - Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major...

    Science.gov (United States)

    2010-10-01

    ... hold a preliminary conference with the parties and/or representatives of the parties within 10 business... request must be made no later than the preliminary conference. (2) Location of hearing. If an in-person hearing is authorized, it will be held at a hearing facility of the arbitration panel's choosing....

  20. New production in the South China Sea

    Institute of Scientific and Technical Information of China (English)

    CAI; Pinghe

    2002-01-01

    [1]Dugdale, R. C., Goering, J. J., Uptake of new and regenerated nitrogen in primary productivity, Limnology and Oceanog-raphy, 1967, 12: 196-206.[2]Eppley, R. W., Peterson, B. J., Particulate organic matter flux and planktonic new production in the deep ocean, Nature, 1979, 282: 677-680.[3]Allen, C. B., Kanda, J., Laws, E. A., New production and photosynthetic rates within and outside a cyclonic mesoscale eddy in the North Pacific Subtropical gyre, Deep-Sea Research Ⅱ, 1996, 43(6): 917-936.[4]Jenkins, W. J., Tritium-helium dating in the Sargasso Sea: A measurement of oxygen utilization rates, Nature, 1977, 196: 291-292.[5]Spitzer, W. S., Jenkins, W. J., Rates of vertical mixing, gas exchange and new production: Estimates from seasonal gas cy-cle in the upper ocean near Bermuda, Journal of Marine Research, 1989, 47: 169-196.[6]Sarmiento, J. L., Thiele, G., Key, R. M. et al., Oxygen and nitrate new production and remineralization in the North At-lantic Subtropical Gyre, Journal of Geophysical Research, 1990, 95: 18303-18315.[7]Ku, T. L., Luo, S., Kusakabe, M. et al., 228Ra-derived nutrient budgets in upper equatorial Pacific and the role of "new" silicate in limiting productivity, Deep-Sea Research II, 1995, 42(2/3): 479-497.[8]Wheeler, P. A., Rates of nitrate assimilation at the equator during the US-JGOFS spring time series: Estimates of new pro-duction, EOS, Transactions, American Geophysical Union, 1992, 73: 281.[9]Huang, Y., Xie, Y., Chen, M. et al., Distribution feature of 228Ra in surface seawater of the Nansha sea area, in Isotopes Marine Chemistry of Nansha Islands Waters (in Chinese), Beijing: Ocean Press, 1996, 70-78.[10]Reid, D. F., Key, R. M., Schink, D., Radium, thorium and actinium extraction from seawater using an improved manga-nese-oxide-coated fiber, Earth and Planetary Science Letters, 1979, 43: 223-226.[11]Shi, W., Qiu, X., Huang, Y., Distribution of dissolved 226Ra in the Jiulongjiang-Xiamen bay

  1. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Science.gov (United States)

    2010-01-01

    ... Category 1(TBq) Category 1(Ci) Category 2(TBq) Category 2(Ci) Actinium-227 20 540 0.2 5.4 Americium-241 60... 2 54 Strontium-90 1,000 27,000 10 270 Thorium-228 20 540 0.2 5.4 Thorium-229 20 540 0.2 5.4...

  2. Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.

    Science.gov (United States)

    Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R; Wai, Chien M

    1999-09-01

    A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

  3. I. The metabolic properties of plutonium and allied materials

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  4. Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours

    Science.gov (United States)

    Millward, M; Underhill, C; Lobb, S; McBurnie, J; Meech, S J; Gomez-Navarro, J; Marshall, M A; Huang, B; Mather, C B

    2013-01-01

    Background: Tremelimumab, a fully human cytotoxic T-lymphocyte antigen 4 monoclonal antibody, and PF-3512676, a Toll-like receptor-9 agonist, are targeted immune modulators that elicit durable single-agent antitumour activity in advanced cancer. Methods: To determine the maximum tolerated dose (MTD) of these agents combined during this phase I study, patients received intravenous tremelimumab (6.0, 10.0, or 15.0 mg kg−1) every 12 weeks plus subcutaneous PF-3512676 (0.05, 0.10, or 0.15 mg kg−1) weekly. Primary end points were safety and tolerability; secondary end points included pharmacokinetics and antitumour activity. Results: Twenty-one patients with stage IV melanoma (n=17) or advanced solid tumours (n=4) were enrolled. Injection-site reactions (n=21; 100%), influenza-like illness (n=18; 86%), and diarrhoea (n=13; 62%) were the most common treatment-related adverse events (TAEs). Grade ⩾3 TAEs were reported (n=7; 33%). Dose-limiting toxicities (prespecified 6-week observation) occurred in one of the six patients in the 10 mg kg−1 tremelimumab plus 0.05 mg kg−1 PF-3512676 cohort (grade 3 hypothalamopituitary disorder) and two of the six patients in the 15 mg kg−1 tremelimumab plus 0.05 mg kg−1 PF-3512676 cohort (grade 3 diarrhoea). Consequently, 15 mg kg−1 tremelimumab plus 0.05 mg kg−1 PF-3512676 exceeded the MTD. Two melanoma patients achieved durable (⩾170 days) partial response. No human antihuman antibody responses to tremelimumab were observed. Conclusion: Weekly PF-3512676 (⩽0.15 mg kg−1) plus tremelimumab (⩽10 mg kg−1 every 12 weeks) was tolerable. PMID:23652314

  5. Estudio Integral del destino Iguazú-Cataratas. Controversias y desafíos para el desarrollo local II. 16H206

    OpenAIRE

    Cammarata, Emilce Beatriz, dir.; Rovira, Viviana; Gandolla, Enrique; Dieckow, Liliana, dir.; Cáceres, Angelina; Núñez, Ana Carolina; Kremar, Ariel; ROMERO, Roberto

    2006-01-01

    El estudio integral del destino IGUAZÚ-CATARATAS. Controversias y desafios para el desarrollo local II. para la presente etapa se propuso el objetivo general de “Contribuir al desarrollo del Destino Iguazú-Cataratas mediante la realización del estudio integral transfronterizo que permita la selección de las mejores alternativas de desarrollo local para la toma de decisiones en los respectivos municipiosciudades e instituciones públicas, privad...

  6. SU-E-T-206: Comparison of EBT and EBT3 RadioChromic Films in Radiation Field of Parotid Cancer Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Toosi, T Bahreyni; Mianaei, F Khorshidi; Ghorbani, M; Khabbaz Kazemi, N Mohammadian; Mohammadi, M [Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Meigooni, A Soleimani [Comprehensive Cancer Center of Nevada, Las Vegas, NV (United States)

    2015-06-15

    Purpose: The aim of the current study is to compare EBT and EBT3 RadioChromic films in dosimetry of radiotherapy fields for treatment of parotid cancer. Methods: The calibrations of EBT and EBT3 films were performed with the same setups for doses ranging from 0.2 Gy to 5 Gy using 6 MV photon beam of a Siemens Primus linac. These films were scanned in color mode (RGB) by a Microtek (1000XL) scanner and the red color channel data was extracted. Treatment planning for parotid cancer radiation therapy was performed on a RANDO phantom. Skin dose was measured at different points in the right anterior oblique (RAO) and right posterior oblique (RPO) fields by EBT and EBT3 films. Results: Dosimetry was performed with the same conditions for the two film types for calibration and in-phantom in parotid cancer radiotherapy. The measured net optical density (NOD) in EBT film was in some extent higher than that from EBT3 film. The minimum difference between these two films under calibration conditions was about 2.9% (for 0.2 Gy). However, the maximum difference was 35.5% (for 0.5 Gy). In the therapeutic fields of parotid cancer radiotherapy at different points, the measured dose from EBT film was higher than the EBT3 film. In these fields the minimum and maximum measured dose differences were 16.0% and 25.5%, respectively. Conclusion: With the same irradiation and reading conditions, EBT film demonstrates higher NOD than the EBT3 film. This effect may be related to the higher sensitivity of EBT film over EBT3 film. However, the obtained dose differences between these two films in low dose range can be due to the differences in fitting functions applied following the calibration process.

  7. 41 CFR 302-9.206 - What should I do if there is no port or terminal at my authorized point of origin or authorized...

    Science.gov (United States)

    2010-07-01

    ... or terminal at your authorized point of origin or authorized destination, your agency will pay the... there is no port or terminal at my authorized point of origin or authorized destination when I transport... Federal Travel Regulation System RELOCATION ALLOWANCES TRANSPORTATION AND STORAGE OF PROPERTY...

  8. 30 CFR 206.356 - How do I calculate royalty or fees due on geothermal resources I use for direct use purposes?

    Science.gov (United States)

    2010-07-01

    ... of the geothermal resource. That amount of thermal energy (in Btu) displaced by the geothermal... accumulating the amount of thermal energy displaced will be determined and approved by BLM under 43 CFR 3275.13... geothermal production in pounds or gallons of geothermal fluid to input into the fee schedule (see 43...

  9. 30 CFR 206.53 - How do I determine value for oil that I or my affiliate do(es) not sell under an arm's-length...

    Science.gov (United States)

    2010-07-01

    ... of the oil being valued under this section), the prices of each of the volumes that the refiner...)) / 23,000 bbl = $33.84/bbl. That price will be the value of the oil produced from the lease and refined... transport oil that you or your affiliate sell(s), which is included in the weighted-average...

  10. 30 CFR 206.52 - How do I calculate royalty value for oil that I or my affiliate sell(s) or exchange(s) under an...

    Science.gov (United States)

    2010-07-01

    ...) You must base value on the highest price that the seller can receive through legally enforceable... prices or benefits to which it is entitled, you must base value on that obtainable price or benefit. (1... value the oil using the NYMEX price, adjusted for applicable location and quality differentials...

  11. SU-E-J-206: A Comparison of Different Hardware Design Approaches for Feature-Supported Optical Head-Tracking with Respect to Angular Dependencies

    Energy Technology Data Exchange (ETDEWEB)

    Stueber, P; Wissel, T; Wagner, B [Institute for Robotics and Cognitive Systems, University of Luebeck, Luebeck (Germany); Graduate School for Computing in Life Science, University of Luebeck, Luebeck (Germany); Bruder, R; Schweikard, A; Ernst, F [Institute for Robotics and Cognitive Systems, University of Luebeck, Luebeck (Germany)

    2014-06-01

    Purpose: Recent research has shown that optical features significantly improve marker-less optical head-tracking for cranial radiotherapy. Simulations, however, showed that these optical features, which are used to derive tissue thickness, depend on the incident angle of the IR scanning laser beam and the perspective of the camera analyzing the reflective patterns. We present an experimental analysis determining which is the most robust optical setup concerning angular influences. Methods: In three consecutive experiments, the incident angle of the laser (1), the perspective of the camera (2) or both simultaneously (3, ‘inBeam’-perspective) were changed with respect to the target. We analyzed how this affects feature intensity. These intensities were determined from seven concentric regions of interest (ROIs) around the laser spot. Two targets were used: a tissue-like silicone phantom and a human's forehead. Results: For each experiment, the feature intensity generally decreases with increasing angle. We found that the optical properties of the silicone phantom do not fit the properties of human skin. Furthermore, the angular influence of the laser on the features is significantly higher than the perspective of the camera. With the ‘inBeam’- perspective, the smoothest decays of feature intensity were found. We suppose that this is because of a fixed relationship between both devices. This smoothness, suggesting a predictable functional relationship, may simplify angle compensation for machine learning algorithms. This is particularly prominent for the medial ROIs. The inner ROIs highly depend on the angle and power of the laser. The outer ROIs show less angular dependency but the signal strength is critically low and prone to artifacts. Therefore and because of the smooth decays, medial ROIs are a suitable tradeoff between susceptibility, signal-noise-ratio and distance to the center of the laser spot. Conclusion: For tissue thickness correlated feature acquisition, the medial ROIs with the ‘inBeam’-setup provide most valuable features This work was supported by Varian Medical Systems Inc. (Palo Alto, CA, USA). In addition, this work was supported by the Graduate School for Computing in Medicine and Life Sciences funded by Germany's Excellence Initiative [DFG GSC 235/1].

  12. MicroRNA-1 and MicroRNA-206 Improve Differentiation Potential of Human Satellite Cells : A Novel Approach for Tissue Engineering of Skeletal Muscle

    NARCIS (Netherlands)

    Koning, Merel; Werker, Paul M. N.; van der Schaft, Daisy W. J.; Bank, Ruud A.; Harmsen, Martin C.

    2012-01-01

    Innovative strategies based on regenerative medicine, in particular tissue engineering of skeletal muscle, are promising for treatment of patients with skeletal muscle damage. However, the efficiency of satellite cell differentiation in vitro is suboptimal. MicroRNAs are involved in the regulation o

  13. 40 CFR 600.206-12 - Calculation and use of FTP-based and HFET-based fuel economy and carbon-related exhaust emission...

    Science.gov (United States)

    2010-07-01

    ... performed using alcohol or natural gas test fuel. (b) If only one equivalent petroleum-based fuel economy... per gallon, will comprise the petroleum-based fuel economy for that configuration. (c) If more than one equivalent petroleum-based fuel economy value exists for an electric vehicle configuration,...

  14. 40 CFR 600.206-93 - Calculation and use of fuel economy values for gasoline-fueled, diesel-fueled, electric, alcohol...

    Science.gov (United States)

    2010-07-01

    ... gallon, will compose the petroleum-based fuel economy for that configuration. (c) If more than one equivalent petroleum-based fuel economy value exists for an electric vehicle configuration, all values for... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Calculation and use of fuel...

  15. 40 CFR 600.206-86 - Calculation and use of fuel economy values for gasoline-fueled, diesel, and electric vehicle...

    Science.gov (United States)

    2010-07-01

    ... part. (b) If only one equivalent petroleum-based fuel economy value exists for an electric... fuel economy for that configuration. (c) If more than one equivalent petroleum-based fuel economy value... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Calculation and use of fuel...

  16. Index to Nuclear Safety: a technical progress review by chrology, permuted title, and author, Volume 11(1) through Volume 20(6)

    Energy Technology Data Exchange (ETDEWEB)

    Cottrell, W B; Passiakos, M

    1980-06-01

    This index to Nuclear Safety, a bimonthly technical progress review, covers articles published in Nuclear Safety, Volume II, No. 1 (January-February 1970), through Volume 20, No. 6 (November-December 1979). It is divided into three sections: a chronological list of articles (including abstracts) followed by a permuted-title (KWIC) index and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center (NSIC), covers all safety aspects of nuclear power reactors and associated facilities. Over 600 technical articles published in Nuclear Safety in the last ten years are listed in this index.

  17. 30 CFR 206.111 - How do I determine a transportation allowance if I do not have an arm's-length transportation...

    Science.gov (United States)

    2010-07-01

    ... oil into or from a vessel, vehicle, pipeline, or other conveyance. (iv) Transfer fees paid to a hub..., including but not limited to the following: (i) Fees paid for long-term storage (more than 30 days). (ii... allocation must use the same proportion as the ratio of the volume of each liquid product (excluding...

  18. Caracterização agronômica e composição química de híbridos de milho - DOI: 10.4025/actascianimsci.v29i2.206 Agronomic evaluation and chemical composition of corn hybrid - DOI: 10.4025/actascianimsci.v29i2.206

    Directory of Open Access Journals (Sweden)

    Augusto Manoel Rodrigues

    2007-11-01

    Full Text Available O trabalho teve por objetivo avaliar a produção de matéria seca total (MST, de colmo (MSc, de folhas (MSf, de espigas (MSe, teores de proteína bruta (PB, fibra em detergente ácido (FDA, altura de planta (AP e relação colmo/folha (C/F de híbridos (Zea mays L. AG 122, AG 519, C 525, C 805, D 170, D 771, G 600, G 1328, P 3041, P 3069, XL 520, XL 530, OC 705, FO 01. Utilizou-se o delineamento experimental inteiramente casualizado, com 10 repetições. O híbrido FO 01 apresentou maior produção de matéria seca, maior altura de planta e maior produção de colmo, porém com menor percentagem de espigas e folhas, prejudicando a qualidade do material original. A maior produtividade apresentada pelos híbridos está associada a maior altura da planta e maior proporção de colmos na matéria seca total. Em geral, uma boa produção de matéria seca, com equilíbrio na relação folhas/colmo/espigas, foi apresentado pelo híbrido G 1328.The objective of this work was to evaluate the total dry matter production (TDMP of stem (DMs, leaves (DMl, ear (DMe, crude protein content (CPC, acid detergent fiber (ADF, plant height (PH and stem/leaves relation (S/L of the hybrids (Zea mays L. AG 122, AG 519, C 525, C 805, D 170, D 771, G 600, G 1328, P 3041, P 3069, XL 520, XL 530, OC 705, FO 01. The results indicated that the hybrid FO 01 showed the highest dry matter production, the highest plant and stem production, but the smallest ear and leaves percentage, decreasing the quality of the original material. The higher productivity of hybrids was associated with a higher plant height and stem production on total dry matter. The hybrid G 1328 showed a good dry matter production with equilibrium in the relation leaves/stem/corn cob.

  19. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  20. Behaviour of uranium series radionuclides in surface water (Crouzille, Limousin). Geochemical implications; Comportement des radionucleides des familles de l'uranium dans les eaux superficielles du site de la Crouzille (Limousin): implications geochimiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-06-15

    Understanding natural radionuclides behaviour in surface water is a required step to achieve uranium mine rehabilitation and preserve water quality. The first objective of this thesis is to determine which are the radionuclides sources in a drinking water reservoir. The second objective is to improve the knowledge about the behaviour of uranium series radionuclides, especially actinium. The investigated site is a brook (Sagnes, Limousin, France) which floods a peat bog contaminated by a former uranium mine and which empties into the Crouzille lake. It allows studying radionuclides transport in surface water and radionuclides retention through organic substance or water reservoir. Radionuclides distribution in particulate, colloidal and dissolved phases is determined thanks to ultra-filtrations. Gamma spectrometry allows measuring almost all natural radionuclides with only two counting stages. However, low activities of {sup 235}U series radionuclides impose the use of very low background well-type Ge detectors, such as those of the Underground Laboratory of Modane (France). Firstly, this study shows that no or few radionuclides are released by the Sagnes peat bog, although its radioactivity is important. Secondly, it provides details on the behaviour of uranium series radionuclides in surface water. More specifically, it provides the first indications of actinium solubility in surface water. Actinium's behaviour is very close to uranium's even if it is a little less soluble. (author)

  1. Eficacia de los criterios de identificación del hormigón en la normativa europea (EN 206 y la reglamentación española (EHE-08

    Directory of Open Access Journals (Sweden)

    Revuelta, D.

    2015-12-01

    Full Text Available European and Spanish regulations establish a series of conformity and acceptance criteria for concrete, as well as identity testing. The effectiveness of the first ones has been sufficiently studied by means of Operative Control Curves that provide the probability of acceptance or rejection of conforming concrete. However, it is not possible to find similar studies in the literature about the effectiveness of the identity criteria, despite their relevance in the decision making process for the manufacturer, the authorities and the consumer. In this paper the authors, using Monte Carlo simulation, have investigated the effectiveness of the European and Spanish identity criteria by obtaining curves with the probability of identifying unsolicited concrete and the probability of rejecting a conforming concrete when applying the criteria.La normativa europea y la reglamentación española establecen una serie de criterios de conformidad y aceptación para el hormigón, así como para la identificación del producto servido. La eficacia de los primeros ha sido suficientemente estudiada mediante el análisis de las Curvas Operativas de Control, que proporcionan la probabilidad de aceptación o rechazo de hormigones conformes. Sin embargo no es posible encontrar en la bibliografía trabajos similares sobre la eficacia de los criterios de identificación, a pesar de la importancia que tienen en la toma de decisiones para el fabricante, el legislador y el consumidor. En este trabajo los autores, empleando la simulación de Monte Carlo, han investigado la eficacia de los criterios de identificación europeos y españoles trazando las curvas de probabilidad de identificación de un hormigón no conforme con lo solicitado, y de la probabilidad de rechazo de un hormigón conforme al aplicar estos criterios.

  2. Review Plan Using the NWD Model Review Plan for Continuing Authorities Program Section 14, 107, 111, 204, 206, 208, 1135 and Projects Directed by Guidance to Use CAP Procedures: Sheridan, Wyoming, Section 1135 Project

    Science.gov (United States)

    2014-12-19

    directed by guidance to use CAP procedures SHERIDAN , WYOMING Section 1135 Project Omaha District MSC Approval Date: 12 January...Projects Directed by Guidance to Use CAP Procedures: Sheridan , Wyoming, Section 1135 Project 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 ii REVIEW PLAN USING THE NWD MODEL REVIEW PLAN SHERIDAN

  3. Corrigendum to "Recycling of crustal material by the Iceland mantle plume: New evidence from nitrogen elemental and isotope systematics of subglacial basalts" [Geochim. Cosmochim. Acta 176 (2016) 206-226

    Science.gov (United States)

    Halldórsson, Sæmundur A.; Hilton, David R.; Barry, Peter H.; Füri, Evelyn; Grönvold, Karl

    2016-08-01

    In Table 1 of the above published paper, N2/40Ar* ratios (column 13) are incorrect. A corrected table and updated figures (Figs. 6-8) are shown below. The correct N2/40Ar* values vary between 178 and 2.6 × 104, with a mean of 4.1 ± 2.1 (×103). Although this range in N2/40Ar* ratios is somewhat smaller compared to what was reported, it still displays considerably more heterogeneity compared to the DMM database. The new mean value is also significantly higher than the DMM mean (138 ± 65), as discussed. Therefore, the findings in the paper concerning heterogeneous and elevated N2/40Ar* ratios in Icelandic subglacial basalts still stand.

  4. Estimation of physical conditions in the cold phase of the ISM in the sub-DLA system at z = 2.06 in the spectrum of the quasar J2123-0050

    CERN Document Server

    Klimenko, V V; Ivanchik, A V; Varshalovich, D A

    2016-01-01

    An independent analysis of the molecular hydrogen absorption system at z = 2.059 in the spectrum of the quasar J2123-0050 is presented. The H_2 system consists of two components (A and B) with column densities log N^A(H_2) = 17.94+/-0.01 and log N^B(H_2) = 15.16+/-0.02. The spectrum exhibits the lines of HD molecules (log N^A(HD) = 13.87+/-0.06) and the neutral species C I and Cl I associated with the H_2 absorption system. For the molecular hydrogen lines near the quasar's Ly_beta and O VI emission lines, we detect a nonzero residual flux, ~3% of the total flux, caused by the effect of partial coverage of the quasar's broad-line region by an H_2 cloud. The uniqueness of the system being investigated is manifested in a high abundance of the neutral species H_2 and C I at the lowest H I column density, log N(H I) = 19.18+/-0.15, among the high redshift systems. The N(HD)/2N(H_2) ratio for component A has turned out to be also unusually high, (4.26+/-0.60)x10^{-5}. We have investigated the physical conditions i...

  5. Dollar Summary of Federal Supply Classification and Service Category by Company. Section 3: Other Services and Construction. Fiscal Year 1993. (S206 Guard Services, Acid Protection Associates-Z300 Restoration Activities). Part 5

    Science.gov (United States)

    1994-03-01

    CU 0 -CeVAW CeMX 4 mZe<= X: mIA( Ln<==>-I- vULA (0 (0U..J.-.4ZLA 6U -- LLILUWCIA 0 (0L.J<U Lnerca.-. M<= -j F- M -J-WF0 Mm< wm-wwumo 04< +3x=- 1-L-.U< 1...4- Ed EdO𔃻CCWddI X:i.E * - O01 *.C-C- 0 :w U <W -ý n0xU * ý -W X - ý - c 0 1 I -U 0" c mc =U- Eda U Ue - W U ) U O - 1Z LL 1 L< UM D0- - L m UL

  6. CTD data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT199-206 during 2008 (NCEI Accession 0059842)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  7. WITHDRAWN: Corrigendum to "World Association for the Advancement of Veterinary Parasitology (WAAVP): The 50th anniversary in 2013-History, achievements, and future perspectives" [Vet. Parasitol. 195 (2013) 206-217].

    Science.gov (United States)

    Eckert, J

    2014-01-15

    The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.vetpar.2013.12.026. The duplicate article has therefore been withdrawn.

  8. Estimation of physical conditions in the cold phase of the interstellar medium in the sub-DLA system at z = 2.06 in the spectrum of the quasar J 2123-0050

    Science.gov (United States)

    Klimenko, V. V.; Balashev, S. A.; Ivanchik, A. V.; Varshalovich, D. A.

    2016-03-01

    An independent analysis of the molecular hydrogen absorption system at redshift z abs = 2.059 in the spectrum of the quasar J 2123-0050 is presented. The H2 system consists of two components (A and B) with column densities log N_{{H_2}}^A = 17.94 ± 0.01 and N_{{H_2}}^B = 15.16 ± 0.02. The spectrum exhibits the lines of HDmolecules (log N HD A = 13.87±0.06) and the neutral speciesCI and Cl I associated with the H2 absorption system. For the molecular hydrogen lines near the quasar's Ly β and OVI emission lines, we detect a nonzero residual flux, 3% of the total flux, caused by the effect of partial coverage of the quasar's broad-line region by an H2 cloud. Due to the smallness of the residual flux, the effect does not affect the H2 column density being determined but increases the statistics of observations of the partial coverage effect to four cases. The uniqueness of the system being investigated is manifested in a high abundance of the neutral species H2 and CI at the lowest HI column density, log N HI = 19.18 ± 0.15, among the highredshift systems. The H2 and CI column densities in the system being investigated turn out to be higher than those in similar systems in our Galaxy and theMagellanic Clouds by two or three orders ofmagnitude. The N_{HD} /2N_{H_2 } ratio for component A has turned out to be also unusually high, (4.26 ± 0.60) × 10-5, which exceeds the deuterium abundance (D/H) for high-redshift systems by a factor of 1.5. Using the HI, H2, HD, and CI column densities as well as the populations of excited H2 and CI levels, we have investigated the physical conditions in components A and B. Component A represents the optically thick case; the gas has a low number density ( 30 cm-3) and a temperature T 140 K. In component B, the mediumis optically thin with n H ≤ 100 cm-3 and T ≥ 100 K. The ultraviolet (UV) background intensity in the clouds exceeds the mean intensity in our Galaxy by almost an order ofmagnitude. A high gas ionization fraction, n_{H^ + } /n_H ˜ 10^{ - 2}, which can be the result of partial shielding of the systemfrom hard UV radiation, is needed to describe the high HD and CI column densities. Using our simulations with the PDRMeudon code, we can reconstruct the observed column densities of the species within the model with a constant density ( n H 40 cm-3). A high H2 formation rate (higher than the mean Galactic value by a factor of 10-40) and high gas ionization fraction and UV background intensity are needed in this case.

  9. Niskin bottle data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT199-206 during 2008 (NCEI Accession 0059936)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  10. Precambrian crustal evolution and Cretaceous–Palaeogene faulting in West Greenland: 207Pb-206Pb dating of magnetite, monazite and allanite in the central and northern Nagssugtoqidian orogen, West Greenland

    Directory of Open Access Journals (Sweden)

    Frei, Robert

    2006-12-01

    Full Text Available Pb-isotopic data for magnetite from amphibolites in the Nagssugtoqidian orogen, central West Greenland, have been used to trace their source characteristics and the timing of metamorphism. Analyses of the magnetite define a Pb-Pb isochron age of 1726 ± 7 Ma. The magnetite is metamorphic in origin, and the 1726 Ma age is interpreted as a cooling age through the closing temperature of magnetite at ~600°C. Some of the amphibolites in this study come from the Naternaq supracrustal rocks in the northern Nagssugtoqidian orogen, which host the Naternaq sulphide deposit and may be part ofthe Nordre Strømfjord supracrustal suite, which was deposited at around 1950 Ma ago.Pb-isotopic signatures of magnetite from the Arfersiorfik quartz diorite in the central Nagssugtoqidian orogen are compatible with published whole-rock Pb-isotopic data from this suite; previous work has shown that it is a product of subduction-related calc-alkaline magmatism between 1920 and 1870 Ma. Intrusion of pegmatites occurred at around 1800 Ma in both the central and the northernparts of the orogen. Pegmatite ages have been determined by Pb stepwise leaching analyses of allanite and monazite, and source characteristics of Pb point to an origin of the pegmatites by melting of the surrounding late Archaean and Palaeoproterozoic country rocks. Hydrothermal activity took place after pegmatite emplacement and continued below the closure temperature of magnetite at 1800–1650 Ma. Because of the relatively inert and refractory nature of magnetite, Pb-isotopic measurements from this mineral may be of help to understand the metamorphic evolution of geologicallycomplex terrains.

  11. 78 FR 60852 - Marine Mammals; File Nos. 16239 and 17312

    Science.gov (United States)

    2013-10-02

    ..., relatedness and stock structure of cetaceans; and (3) suction-cup tag, track, and collect passive acoustic...; phone (206)526-6150; fax (206)526-6426; Alaska Region, NMFS, P.O. Box 21668, Juneau, AK...

  12. 18 CFR 385.1102 - Definitions (Rule 1102).

    Science.gov (United States)

    2010-04-01

    ... incrementally priced industrial boiler fuel facilities from section 201 of the NGPA, under the authority of section 206(d) of the NGPA and § 282.206 (industrial boiler fuel facilities exemption); (b)...

  13. Gclust Server: 1521 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 1521 PoTR_597173 Cluster Sequences Related Sequences(34) 206 eugene3.89040001 55 1....nces Cluster Sequences Link to related sequences Related Sequences(34) Sequence length 206 Representative annotation eugene

  14. Gclust Server: 19410 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 19410 PoTR_581027 Cluster Sequences Related Sequences(206) 153 eugene3.01250025 5 1...ces Cluster Sequences Link to related sequences Related Sequences(206) Sequence length 153 Representative annotation eugene

  15. DISSOLVED CONCENTRATION LIMITS OF RADIOACTIVE ELEMENTS

    Energy Technology Data Exchange (ETDEWEB)

    P. Bernot

    2005-07-13

    The purpose of this study is to evaluate dissolved concentration limits (also referred to as solubility limits) of elements with radioactive isotopes under probable repository conditions, based on geochemical modeling calculations using geochemical modeling tools, thermodynamic databases, field measurements, and laboratory experiments. The scope of this activity is to predict dissolved concentrations or solubility limits for elements with radioactive isotopes (actinium, americium, carbon, cesium, iodine, lead, neptunium, plutonium, protactinium, radium, strontium, technetium, thorium, and uranium) relevant to calculated dose. Model outputs for uranium, plutonium, neptunium, thorium, americium, and protactinium are provided in the form of tabulated functions with pH and log fCO{sub 2} as independent variables, plus one or more uncertainty terms. The solubility limits for the remaining elements are either in the form of distributions or single values. Even though selection of an appropriate set of radionuclides documented in Radionuclide Screening (BSC 2002 [DIRS 160059]) includes actinium, transport of Ac is not modeled in the total system performance assessment for the license application (TSPA-LA) model because of its extremely short half-life. Actinium dose is calculated in the TSPA-LA by assuming secular equilibrium with {sup 231}Pa (Section 6.10); therefore, Ac is not analyzed in this report. The output data from this report are fundamental inputs for TSPA-LA used to determine the estimated release of these elements from waste packages and the engineered barrier system. Consistent modeling approaches and environmental conditions were used to develop solubility models for the actinides discussed in this report. These models cover broad ranges of environmental conditions so they are applicable to both waste packages and the invert. Uncertainties from thermodynamic data, water chemistry, temperature variation, and activity coefficients have been quantified or

  16. Gene : CBRC-MDOM-11-0075 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available 39859 /gi=89886377 /ug=Mdm.206 /len=927 3e-05 22% MISSELIFGVAFFFQCAIGIVGNSLLLVLYVCIAFKKPQEKKPMDLILAHLTVANM...ATLFTRGIPEIMFCIGMRNVLNDLGCKVVMYIYRISRGFSVCTTSLLSMFQAIIISPNNSVWAMIKVKAHKYILHCFLFFCVT

  17. Analysis of the Yrast Bands with q-Deformed Moment of Inertia

    Institute of Scientific and Technical Information of China (English)

    FANG Xiang-Zheng; RUAN Tu-Nan

    2001-01-01

    The rigid-rotor with a q-deformed moment of inertia is introduced to describe the nuclear rotational spectra. With the representations of quantum algebra, the normal deformed and superdeformed bands are naturally differentiated by softness. The yrast normal deformed bands in rare earth and actinium regions, as well as the yrast superdeformed bands in A-190 and 150 regions are investigated. The calculated results agree with experimental data qualitatively well, and the values of the parameters are physically reasonable. This indicates that the fixed deformation, the stretching effect and the many body statistics effect are three possible dominant factors to govern nuclear rotational bands.

  18. Transition wavelengths and unresolved transition array statistics of ions with Z = 72-89

    Energy Technology Data Exchange (ETDEWEB)

    Kilbane, D, E-mail: Deirdre.Kilbane@ucd.ie [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland)

    2011-08-28

    Potential extreme ultraviolet and soft x-ray radiation sources have been identified, using the flexible atomic code (FAC), as emission peaks arising from the 4d-4f and 4p-4d transitions in Pd-like to Rb-like ions of hafnium through actinium. The effects of configuration interaction are investigated and for increasing nuclear charge, these strong emitters are seen to separate and move to shorter wavelengths. Each source is characterized using the unresolved transition array model. They are proposed to complement the currently used nitrogen and argon sources in the 'water window', and as possible successors to tin in next-generation lithography.

  19. Detection of rare earth elements in Powder River Basin sub-bituminous coal ash using laser-induced breakdown spectroscopy (LIBS)

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Phuoc [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State; Mcintyre, Dustin [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United State

    2015-10-01

    We reported our preliminary results on the use of laser-induced breakdown spectroscopy to analyze the rare earth elements contained in ash samples from Powder River Basin sub-bituminous coal (PRB-coal). We have identified many elements in the lanthanide series (cerium, europium, holmium, lanthanum, lutetium, praseodymium, promethium, samarium, terbium, ytterbium) and some elements in the actinide series (actinium, thorium, uranium, plutonium, berkelium, californium) in the ash samples. In addition, various metals were also seen to present in the ash samples

  20. 78 FR 66252 - Airworthiness Directives; Bell Helicopter Textron Canada Limited (Bell) Helicopters

    Science.gov (United States)

    2013-11-05

    ... prompted by AD No. CF-2007-13R2, dated November 10, 2009, issued by Transport Canada Civil Aviation (TCCA), which is the aviation authority for Canada. TCCA issued AD No. CF-2007-13R2 to correct an unsafe condition for certain Model 206B (including those converted from Model 206A) and 206L helicopters....

  1. 30 CFR 202.100 - Royalty on oil.

    Science.gov (United States)

    2010-07-01

    ... determined in accordance with 30 CFR part 206. (d) If a lessee receives insurance compensation for... communitized leases will be determined in accordance with 30 CFR part 206. In applying the requirements of 30 CFR part 206, the circumstances involved in the actual disposition of the portion of the production...

  2. Purification of cerium, neodymium and gadolinium for low background experiments

    Directory of Open Access Journals (Sweden)

    Boiko R.S.

    2014-01-01

    Full Text Available Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search, 136Ce (2β+ candidate with one of the highest Q2β. The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  3. The Technological Enhancement of Normally Occurring Radioactive Materials in Red Mud due to the Production of Alumina

    Directory of Open Access Journals (Sweden)

    Maurice O. Miller

    2016-01-01

    Full Text Available This study investigates the level of technological enhancement of normally occurring radioactive materials (TENORM in the red mud waste due to the production of alumina in Jamaica. Technological enhancements factors (TEF were determined for the uranium, thorium, actinium series, their progenies, and the nonseries potassium-40 using gamma spectrometry. The study concluded that bauxite production technologically enhances the uranium progenies Th-234, Pb-214, Bi-214, and Pa-234 and the thorium-232 progenies Ac-228, Pb-212, and Bi-212 in red mud. The actinium series was technologically enhanced, but K-40 and the thorium daughter, Tl-208, were reduced. The spectrometric comparison of Tl-208 (at 510 keV was unexpected since its other photopeaks at 583 keV, 934 keV, and 968 keV were markedly different. An explanation for this anomaly is discussed. An explanation regarding the process of accumulation and fractionation of organically derived phosphate deposits and potassium-feldspar is offered to explain the spectrometric differences between the alumina product and its waste material, red mud.

  4. Reseña: Cruz Mundet, José Ramón. Diccionario de Archivística (con equivalencias en inglés, francés, alemán, portugués, catalán, euskera y gallego). Madrid: Alianza, 2011, 363 págs. ISBN: 978-84-206-5285-6.

    OpenAIRE

    Delgado-Gómez, Alejandro

    2011-01-01

    Review of a dictionary by Cruz Mundet: a thoughtful work, rigorous, original in its treatment, and, more importantly, useful for our daily tasks and for our theoretical speculation. A "portable" dictionary, essential to our professional libraries.

  5. Empowerment Zones and Enterprise Districts, Polygon boundaries representing the geographic extent of Base Realignment and Closure (BRAC) revitalization and incentive zones as set forth by SB206 BRAC Communty Enhancement Act. Focus growth in areas already designated for growth., Published in 2010, Smaller than 1:100000 scale, Maryland Department of Business and Economic Development.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Empowerment Zones and Enterprise Districts dataset, published at Smaller than 1:100000 scale, was produced all or in part from Hardcopy Maps information as of...

  6. Sebastián Vargas Álvarez. Desentonando el himno de Bogotá: historia y crítica de un símbolo (1974-2010. Bogotá: Universidad del Rosario, Pontificia Universidad Javeriana, 2014. 206 páginas

    Directory of Open Access Journals (Sweden)

    Slenka Leandra Botello Gil

    2015-07-01

    Full Text Available En el libro se hace una invitación a pensar la historia en la contemporaneidad, como una herramienta de transformación social, de emancipación para las luchas sociales y culturales. Al sumergirse en la argumentación que presenta el autor, el lector devela un escenario muy amplio, que desborda los límites del estudio de la historia en la academia y que le permite observar un proyecto de varios años, en los que Vargas desarrolló su propuesta política desde la “microfísica del poder”.

  7. 三核镍配合物[Ni3(Htrz)6(H2O)6](S04)3·8H2O的合成与晶体结构%Synthesis and Crystal Structure of New Trinuclear Ni Complex [ Ni3(Htrz)6(H20)6]( SO4)3· 8H20

    Institute of Scientific and Technical Information of China (English)

    曲小姝; 杨艳艳; 于雷; 邢丽娜; 王金龙

    2012-01-01

    用常规水溶液法合成了三核配合物[Ni3(Htrz)。(H:0)6](SO4)3·8H:O(1),其中Htrz=1,2,4—1H-三氮唑.用x.射线单晶衍射、元素分析、红外光谱、热重分析对晶体结构进行了表征.该晶体属于三斜晶系,P-1空间群,Ⅱ=11.802(2)A,b=12.120(3)A,c=18.663(4)A,α=71.28(0)°,β:86.66(0)°,γ=62.04(0)°,V=2219.5(8)A3,Z=2,F(000):1666,R1=0.1217,wR2=0.3600.CCDC:831634%A new trinuclear Ni complex [ Ni3 (Htrz) 6 ( H2 O) 6 ] ( SO4 ) 3 · 8H20 ( Htrz = 1,2,4-1H-Triazole) has been synthesized by convenient aqueous solution method and structurally characterized by single-crystal X- ray diffraction, IR spectra, elemental analysis, thermogravimetric analysis (TGA). Crystal data for this compound :Wrielinic, P-1 ,a = 11. 802(2)A,b = 12. 120(3) A, c = 18. 663 (4) A, α =71.28 (0) ° ,β= 86.66(0) °, γ= 62.04(0) ~,V=2219.5(8) A^3,Z=2,F(000) =1666,Rl =0.1217, wRz=0.3600. CCDC:831634

  8. 75 FR 9345 - Michigan: Final Authorization of State Hazardous Waste Management Program Revision

    Science.gov (United States)

    2010-03-02

    ... Michigan Department of Natural Resources and Environment, Waste and Hazardous Materials Division... Register date Analogous State authority requirement \\1\\ and page Non-wastewaters from Dyes and 206,...

  9. Process for radioisotope recovery and system for implementing same

    Science.gov (United States)

    Meikrantz, David H.; Todd, Terry A.; Tranter, Troy J.; Horwitz, E. Philip

    2007-01-02

    A method of recovering daughter isotopes from a radioisotope mixture. The method comprises providing a radioisotope mixture solution comprising at least one parent isotope. The at least one parent isotope is extracted into an organic phase, which comprises an extractant and a solvent. The organic phase is substantially continuously contacted with an aqueous phase to extract at least one daughter isotope into the aqueous phase. The aqueous phase is separated from the organic phase, such as by using an annular centrifugal contactor. The at least one daughter isotope is purified from the aqueous phase, such as by ion exchange chromatography or extraction chromatography. The at least one daughter isotope may include actinium-225, radium-225, bismuth-213, or mixtures thereof. A liquid-liquid extraction system for recovering at least one daughter isotope from a source material is also disclosed.

  10. Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion

    Science.gov (United States)

    Ferrer, R.; Barzakh, A.; Bastin, B.; Beerwerth, R.; Block, M.; Creemers, P.; Grawe, H.; de Groote, R.; Delahaye, P.; Fléchard, X.; Franchoo, S.; Fritzsche, S.; Gaffney, L. P.; Ghys, L.; Gins, W.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Loiselet, M.; Lutton, F.; Moore, I. D.; Martínez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Raeder, S.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Thomas, J-C; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2017-01-01

    Resonant laser ionization and spectroscopy are widely used techniques at radioactive ion beam facilities to produce pure beams of exotic nuclei and measure the shape, size, spin and electromagnetic multipole moments of these nuclei. However, in such measurements it is difficult to combine a high efficiency with a high spectral resolution. Here we demonstrate the on-line application of atomic laser ionization spectroscopy in a supersonic gas jet, a technique suited for high-precision studies of the ground- and isomeric-state properties of nuclei located at the extremes of stability. The technique is characterized in a measurement on actinium isotopes around the N=126 neutron shell closure. A significant improvement in the spectral resolution by more than one order of magnitude is achieved in these experiments without loss in efficiency. PMID:28224987

  11. Temporal Variations in Surface Concentrations of Terrestrial Lead 210 and Uranium 235 Radionucleides

    Science.gov (United States)

    Yoshimori, M.

    We have started to measure the surface concentrations of terrestrial radionucleides of lead 210 and uranium 235 in Tokyo (N35, E139) in 2002. Lead 210 which is a daughter nucleus of Rn-222 (uranium series) emits 46 keV gamma-ray with a half-life of 22.4 years, while uranium 235 (actinium series) emits a gamma-ray at 186 keV with a half-life of 0.7 billion years. The present measurement of the surface concentration of lead 210 exhibits two peaks in spring and fall, similar to the beryllium 7 seasonal variations, while the uranium 235 concentration does not vary with time within statistical errors. These two terrestrial radionucleides exhibit different temporal variations on the surface. We discuss possible explanations for the differences in the temporal variations from a point of view of differences in their altitude distribution.

  12. 两种稀土产品中放射性核素分析研究%ANALYSIS OF RADIONUCLIDES IN TWO RARE EARTH PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    周程; 孙恋君

    2009-01-01

    利用高纯锗γ谱仪对两个稀土产品氯化镧和氯化钇的样品进行能谱分析,研究经湿法冶炼工艺后的稀土产品中放射性核素的活度变化.结果表明,样品中存在天然放射性钍系和锕-铀系的核素,以及天然放射性核素~(138)La和~(176)Lu,但两个样品中所含的放射性核素不相同.氯化镧产品中锕-铀系和钍系核素放射性未达平衡,其主要子体~(224)Ra和~(227)Th的含量随时间发生明显变化,约60天达到平衡;而氯化钇产品没有这种现象.%This paper describes a study on raidoactivity change of rare-earth products after hydrometallurgy technology,using HPGe gamma spectrometer to analyze two rare earth products (LaCl_3 and YCl_3).The results show that in the two samples exist natural radionuclides of thorium series and actinium-uranium series as well as other natural radionuclides 138 La and 176 Lu.In the sample of lanthanum chloride the radioactivity of actinium-uranium series and thorium series has not reached balance,the contents of their main progenies ~(226)Ra and ~(227)Th obviously changes with the time,reaching balance 60 days later,while YCl_3 keeps stability.

  13. Evaluation of total effective dose due to certain environmentally placed naturally occurring radioactive materials using a procedural adaptation of RESRAD code.

    Science.gov (United States)

    Beauvais, Z S; Thompson, K H; Kearfott, K J

    2009-07-01

    Due to a recent upward trend in the price of uranium and subsequent increased interest in uranium mining, accurate modeling of baseline dose from environmental sources of radioactivity is of increasing interest. Residual radioactivity model and code (RESRAD) is a program used to model environmental movement and calculate the dose due to the inhalation, ingestion, and exposure to radioactive materials following a placement. This paper presents a novel use of RESRAD for the calculation of dose from non-enhanced, or ancient, naturally occurring radioactive material (NORM). In order to use RESRAD to calculate the total effective dose (TED) due to ancient NORM, a procedural adaptation was developed to negate the effects of time progressive distribution of radioactive materials. A dose due to United States' average concentrations of uranium, actinium, and thorium series radionuclides was then calculated. For adults exposed in a residential setting and assumed to eat significant amounts of food grown in NORM concentrated areas, the annual dose due to national average NORM concentrations was 0.935 mSv y(-1). A set of environmental dose factors were calculated for simple estimation of dose from uranium, thorium, and actinium series radionuclides for various age groups and exposure scenarios as a function of elemental uranium and thorium activity concentrations in groundwater and soil. The values of these factors for uranium were lowest for an adult exposed in an industrial setting: 0.00476 microSv kg Bq(-1) y(-1) for soil and 0.00596 microSv m(3) Bq(-1) y(-1) for water (assuming a 1:1 234U:238U activity ratio in water). The uranium factors were highest for infants exposed in a residential setting and assumed to ingest food grown onsite: 34.8 microSv kg Bq(-1) y(-1) in soil and 13.0 microSv m(3) Bq(-1) y(-1) in water.

  14. Origin of elements of the Uranium-235 family observed in the Ellez river near the EL-4 experimental nuclear reactor in dismantling (Monts d'Arree- Finistere department); Origine des elements de la famille de l'uranium-235 observes dans la riviere Ellez a proximite du reacteur nucleaire experimental EL4 en cours de demantelement (Mont d'Arree - departement du Finistere). Resultats et premiers constats annee 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    In a previous study which concerned the catchment basin of the harbour of Brest, the A.C.R.O. put in evidence a marking by artificial radioelements around the power plant of Brennilis which can be imputed without ambiguities to the nuclear installation. It also put in evidence abnormalities concerning the natural radioactivity which justifies this new study. In the area of the Monts d'Arree, actinium 227 ({sup 227}Ac), non born by its ascendents which are {sup 235}U and {sup 231}Pa is observed. This phenomenon is characterized by mass activities superior to these ones of {sup 235}U and able to reach these ones of {sup 238}U. Its presence corresponds with the drainage of the Ellez river since the former channel of radioactive effluents releases from the nuclear power plant EL-4 up to the reservoir Saint-Herblot situated 6 km downstream. The strongest values of radioactivity are registered near the disused power plant, at this place a relationship exists between the level of actinium 227 and this one of the artificial radioactivity as it exists a relationship with the decay products of radon exhaled from the subsoil ({sup 210}Pb). But its presence is not limited to a part of the Ellez river, it is equally observed in terrestrial medium, in places in priori not influenced by the direct liquid effluents of the power plant. This place is situated at more than 4 km and without any connection with the Ellez waters. At this stage of the study, it is not possible to answer with certainty the question of the origin of this phenomenon. A new reorientation is considered indispensable to clarify definitively the origin of this unknown phenomenon in the scientific publications and the environmental monitoring. (N.C.)

  15. 77 FR 3922 - Rules for Investigations Relating to Global and Bilateral Safeguards Actions, Market Disruption...

    Science.gov (United States)

    2012-01-26

    ..., Market Disruption, Trade Diversion, and Review of Relief Actions AGENCY: United States International... governing investigations relating to global and bilateral safeguard actions, market disruption, trade... DISRUPTION, AND REVIEW OF RELIEF ACTIONS Section 206.1 of subpart 206, which lists the statutory...

  16. EST Table: BB986379 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to putative lysosomal glucocerebrosidase [Tribolium castaneum] 10/08/28 low homology 10/08/27 35 %/211 aa... %/206 aa gnl|Amel|GB13722-PA 10/09/10 43 %/206 aa gi|91087345|ref|XP_975608.1| PREDICTED: similar to putative lysosomal glucocerebrosidase [Tribolium castaneum] BB985877 MSV3 ...

  17. EST Table: BB986249 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to putative lysosomal glucocerebrosidase [Tribolium castaneum] 10/08/28 low homology 10/08/27 35 %/211 aa... %/206 aa gnl|Amel|GB13722-PA 10/09/10 42 %/206 aa gi|91087345|ref|XP_975608.1| PREDICTED: similar to putative lysosomal glucocerebrosidase [Tribolium castaneum] BB985877 MSV3 ...

  18. 12 CFR 7.1016 - Independent undertakings to pay against documents.

    Science.gov (United States)

    2010-01-01

    ... Publishing, Inc., 212/206-1150; http://www.iccwbo.org); the Supplements to UCP 500 & 600 for Electronic... Electronic Presentation) (available from ICC Publishing, Inc., 212/206-1150; http://www.iccwbo.org... value other than money, the bank should ensure that market fluctuations that affect the value of...

  19. 75 FR 69432 - Ross Bachofer v. Calpine Corporation; Notice of Complaint

    Science.gov (United States)

    2010-11-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Ross Bachofer v. Calpine Corporation; Notice of Complaint November 4, 2010..., 18 CFR 385.206 and section 206 of the Federal Power Act, 16 U.S.C. 2824c, Ross Bachofer...

  20. 78 FR 23538 - Marine Mammals; File No. 17312

    Science.gov (United States)

    2013-04-19

    ... Features box on the Applications and Permits for Protected Species (APPS) home page, https://apps.nmfs.noaa... cetaceans; and (3) suction-cup tag, track, and collect passive acoustic recordings to study cetacean diving...; phone (206)526-6150; fax (206)526-6426; Alaska Region, NMFS, P.O. Box 21668, Juneau, AK...