WorldWideScience

Sample records for act regulations standard

  1. Safe drinking water act: Amendments, regulations and standards

    International Nuclear Information System (INIS)

    Calabrese, E.J.; Gilbert, C.E.; Pastides, H.

    1989-01-01

    This book approaches the topic of safe drinking water by communicating how the EPA has responded to the mandates of Congress. Chapter 1 summarizes what is and will be involved in achieving safe drinking water. Chapter 2 describes the historical development of drinking water regulations. Chapter 3 summarizes the directives of the Safe Drinking Water Act Amendments of 1986. Chapters 4 through 9 discuss each phase of the regulatory program in turn. Specific problems associated with volatile organic chemicals, synthetic organics, inorganic chemicals, and microbiological contaminants are assessed in Chapter 4 and 5. The unique characteristics of radionuclides and their regulation are treated in Chapter 6. The disinfection process and its resultant disinfection by-products are presented in Chapter 7. The contaminant selection process and the additional contaminants to be regulated by 1989 and 1991 and in future years are discussed in Chapters 8 and 9. EPA's Office of Drinking Water's Health Advisory Program is explained in Chapter 10. The record of public water system compliance with the primary drinking water regulations is detailed in Chapter 11. Chapter 12 offers a nongovernmental perspective on the general quality of drinking water and how this is affected by a wide range of drinking water treatment technologies. Separate abstracts are processed for 5 chapters in this book for inclusion in the appropriate data bases

  2. 78 FR 70515 - Petition To Promulgate Standards for Bears Under the Animal Welfare Act Regulations

    Science.gov (United States)

    2013-11-26

    ... the Animal Welfare Act Regulations AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION... Service has received a petition requesting that we amend the Animal Welfare Act regulations to add..., Riverdale, MD 20737-1234; (301) 851-3751. SUPPLEMENTARY INFORMATION: Background The Animal Welfare Act (AWA...

  3. 29 CFR 1903.2 - Posting of notice; availability of the Act, regulations and applicable standards.

    Science.gov (United States)

    2010-07-01

    ... compliance with the posting requirements of section 8(c)(1) of the Act. Employers whose operations are not... business is conducted or where services or industrial operations are performed. (For example: A factory, mill, store, hotel, restaurant, movie theatre, farm, ranch, bank, sales office, warehouse, or central...

  4. 76 FR 79529 - Community Reinvestment Act Regulations

    Science.gov (United States)

    2011-12-22

    ... ``agencies'') are amending their Community Reinvestment Act (CRA) regulations to adjust the asset-size... ``intermediate small savings association.'' As required by the CRA regulations, the adjustment to the threshold... Description of the Joint Final Rule The agencies' CRA regulations establish CRA performance standards for...

  5. The French Space Operation Act: Technical Regulations

    Science.gov (United States)

    Trinchero, J. P.; Lazare, B.

    2010-09-01

    The French Space Operation Act(FSOA) stipulates that a prime objective of the National technical regulations is to protect people, property, public health and the environment. Compliance with these technical regulations is mandatory as of 10 December 2010 for space operations by French space operators and for space operations from French territory. The space safety requirements and regulations governing procedures are based on national and international best practices and experience. A critical design review of the space system and procedures shall be carried out by the applicant, in order to verify compliance with the Technical Regulations. An independent technical assessment of the operation is delegated to CNES. The principles applied when drafting technical regulations are as follows: requirements must as far as possible establish the rules according to the objective to be obtained, rather than how it is to be achieved; requirements must give preference to international standards recognised as being the state of the art; requirements must take previous experience into account. Technical regulations are divided into three sections covering common requirements for the launch, control and return of a space object. A dedicated section will cover specific rules to be applied at the Guiana Space Centre. The main topics addressed by the technical regulations are: operator safety management system; study of risks to people, property, public health and the Earth’s environment; impact study on the outer space environment: space debris generated by the operation; planetary protection.

  6. Black Lung Benefits Act: standards for chest radiographs. Final rule.

    Science.gov (United States)

    2014-04-17

    Physicians and adjudicators use chest radiographs (X-rays) as a tool in evaluating whether a coal miner suffers from pneumoconiosis (black lung disease). Accordingly, the Department's regulations implementing the Black Lung Benefits Act allow the submission of radiographs in connection with benefit claims and set out quality standards for administering and interpreting film-based chest radiographs. This final rule updates the Department's existing film-radiograph standards and provides parallel standards for digital radiographs. This rule also updates outdated terminology and removes certain obsolete provisions.

  7. The NSW Radiation Control Act and regulation

    International Nuclear Information System (INIS)

    Towson, J.

    1994-01-01

    The legal control of radiation safety in New South Wales has undergone substantial change in recent years. The long-awaited Regulation to the 1990 Radiation Control Act came into effect on 1 September 1993 (of necessity, as the Regulation to the previous 1957 Radioactive Substances Act expired on that date). It has not met with unanimous acclaim. The Regulation addresses three broad areas, namely - (a) legal controls - licensing, registration, radiation 'experts'; (b) safety matters - workplace management, monitoring, research exposures, transport/disposal, accidents; and (c) miscellaneous -radiation safety officers, committees, penalties, records, This article offers a personal view of the implications for nuclear medicine practice in New South Wales

  8. 48 CFR 22.1002-4 - Application of the Fair Labor Standards Act minimum wage.

    Science.gov (United States)

    2010-10-01

    ... Labor Standards Act minimum wage. 22.1002-4 Section 22.1002-4 Federal Acquisition Regulations System... its employees working on the contract less than the minimum wage specified in section 6(a)(1) of the... Service Contract Act of 1965, as Amended 22.1002-4 Application of the Fair Labor Standards Act minimum...

  9. Drinking Water Contaminants -- Standards and Regulations

    Science.gov (United States)

    ... and Research Centers Contact Us Share Drinking Water Contaminants – Standards and Regulations EPA identifies contaminants to regulate ... other partners to implement these SDWA provisions. Regulated Contaminants National Primary Drinking Water Regulations (NPDWRs) - table of ...

  10. 75 FR 82217 - Community Reinvestment Act Regulations

    Science.gov (United States)

    2010-12-30

    ... Thrift Supervision 12 CFR Part 563e [Docket ID OTS-2010-0032] RIN 1550-AC45 Community Reinvestment Act... Federal Reserve System (Board); Federal Deposit Insurance Corporation (FDIC); Office of Thrift Supervision...) regulations to adjust the asset-size thresholds used to define ``small bank'' or ``small savings association...

  11. 48 CFR 52.222-44 - Fair Labor Standards Act and Service Contract Act-Price Adjustment.

    Science.gov (United States)

    2010-10-01

    ... and Service Contract Act-Price Adjustment. 52.222-44 Section 52.222-44 Federal Acquisition Regulations... CLAUSES Text of Provisions and Clauses 52.222-44 Fair Labor Standards Act and Service Contract Act—Price... Contract Act—Price Adjustment (SEP 2009) (a) This clause applies to both contracts subject to area...

  12. 77 FR 14688 - Application of the Fair Labor Standards Act to Domestic Service

    Science.gov (United States)

    2012-03-13

    ... to revise the Fair Labor Standards Act minimum wage, overtime and recordkeeping regulations... DEPARTMENT OF LABOR Wage and Hour Division 29 CFR Part 552 RIN 1235-AA05 Application of the Fair Labor Standards Act to Domestic Service AGENCY: Wage and Hour Division, Labor. ACTION: Extension of...

  13. 77 FR 11021 - Application of the Fair Labor Standards Act to Domestic Service

    Science.gov (United States)

    2012-02-24

    ... proposing to revise the Fair Labor Standards Act minimum wage, overtime and recordkeeping regulations... DEPARTMENT OF LABOR Wage and Hour Division 29 CFR Part 552 RIN 1235-AA05 Application of the Fair Labor Standards Act to Domestic Service AGENCY: Wage and Hour Division, Labor. ACTION: Notice and...

  14. Good Practice Standards – a Regulation Tool

    DEFF Research Database (Denmark)

    Sørensen, Marie Jull

    2013-01-01

    The purpose of this article is to identify the considerations weighed in regulation with good practice standards. In this article, potential due process problems with regulation via legal standards are identified and compared to other considerations, which this regulation technique meets....

  15. Medical devices regulations, standards and practices

    CERN Document Server

    Ramakrishna, Seeram; Wang, Charlene

    2015-01-01

    Medical Devices and Regulations: Standards and Practices will shed light on the importance of regulations and standards among all stakeholders, bioengineering designers, biomaterial scientists and researchers to enable development of future medical devices. Based on the authors' practical experience, this book provides a concise, practical guide on key issues and processes in developing new medical devices to meet international regulatory requirements and standards. Provides readers with a global perspective on medical device regulationsConcise and comprehensive information on how to desig

  16. 75 FR 63703 - Privacy Act of 1974; Privacy Act Regulation

    Science.gov (United States)

    2010-10-18

    ... FEDERAL RESERVE SYSTEM 12 CFR Part 261a [Docket No. R-1313] Privacy Act of 1974; Privacy Act... implementing the Privacy Act of 1974 (Privacy Act). The primary changes concern the waiver of copying fees... records under the Privacy Act; the amendment of special procedures for the release of medical records to...

  17. Radiation safety standards and regulations

    International Nuclear Information System (INIS)

    Ermolina, E.P.; Ivanov, S.I.

    1993-01-01

    Radiation protection laws of Russia concerning medical application of ionizing radiation are considered. Main concepts of the documents and recommendations are presented. Attention was paid to the ALARA principle, safety standrds for paietients, personnel and population, radiation protection. Specific feature of the standardization of radiation factors is the establishment of two classes of norms: main dose limits and permissible levels. Maximum dose commitment is the main standard. Three groups of critical organs and three categories of the persons exposed to radiation are stated. Main requirements for radiation protection are shown

  18. 78 FR 17176 - Federal Acquisition Regulation; Defense Base Act

    Science.gov (United States)

    2013-03-20

    ... Regulation; Defense Base Act AGENCIES: Department of Defense (DoD), General Services Administration (GSA... the Defense Base Act. DATES: Interested parties should submit written comments to the Regulatory... Act as extended by the Defense Base Act. II. Discussion and Analysis The Defense Base Act of 1941...

  19. Act to amend cost regulations of the Atomic Energy Act

    International Nuclear Information System (INIS)

    1980-01-01

    Article 21 is replaced by articles 21 to 21b. According to this, fees or reimbursements for expenses for official acts (e.g. decisions, supervisory acts, safeguarding of nuclear fuels) as well as for the use of facilities according to article 9a, section 3, of the Atomic Energy Act (e.g. Laender facilities to collect nuclear waste). (HP) [de

  20. 78 FR 6216 - Freedom of Information Act Regulations

    Science.gov (United States)

    2013-01-30

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary 43 CFR Part 2 RIN 1093-AA15 Freedom of... regulation revises the Department's Freedom of Information Act regulations. DATES: Effective January 30, 2013... 31, 2012, revising the Department of the Interior Freedom of Information Act (FOIA) regulations. This...

  1. Preschools Under the Fair Labor Standards Act. (Revised).

    Science.gov (United States)

    Employment Standards Administration (DOL), Washington, DC. Wage and Hour Div.

    This pamphlet provides general information concerning the application of the Fair Labor Standards Act (FLSA) to employees of preschool centers. The contents include discussion of the purview of the Act regarding preschools; monetary requirements such as minimum wages and employee facilities; provisions for equal pay, overtime pay, work hours,…

  2. European standards and regulation - CEN/CENELEC

    Energy Technology Data Exchange (ETDEWEB)

    Caballero, J. [AENOR, Madrid (Spain)

    1997-02-27

    An overview is given of the European Standards structure, as well as the general Directives and Regulations related to the Heating, Ventilation and Air Conditioning Sector. The importance of standardisation, both on quality and as a strategic tool for manufacturers, is stressed. Participation in the elaboration of standards makes it possible to reflect a manufacturer`s technology in the standards. Voluntary standardisation can be used as a differentiating element. European standards for the HVAC sector are being elaborated by the European Standardisation Committee (CEN), the European Electrotechnical Standardisation Committee (CENELEC) and by the European Telecommunication Institute (ETSI)

  3. 76 FR 31790 - Federal Seed Act Regulations

    Science.gov (United States)

    2011-06-02

    ... improvements in the noxious-weed seed tolerances using modern statistical applications. The AOSA has already... the introductory text. 0 B. Removing the word ``act'' and adding in its place the word ``Act'', and by...'' in paragraph (c)(2) introductory text. Sec. 201.41 [Amended] 0 6. In Sec. 201.41, paragraph (a), the...

  4. Institutions of Higher Education Under the Fair Labor Standards Act.

    Science.gov (United States)

    Employment Standards Administration (DOL), Washington, DC. Wage and Hour Div.

    The Fair Labor Standards Act contains provisions and standards concerning minimum wages, equal pay, maximum hours and overtime pay, recordkeeping, and child labor. These basic requirements apply to employees engaged in interstate commerce or in the production of goods for interstate commerce and also to employees in certain enterprises that are so…

  5. 75 FR 79278 - Community Reinvestment Act Regulations

    Science.gov (United States)

    2010-12-20

    ... Congressional intent that the funds have maximum impact and be targeted to States and local communities with the... communities affected by high levels of foreclosures and delinquencies. \\12\\ The Board also received over 650... Thrift Supervision 12 CFR Part 563e [Docket ID OTS-2010-0031] RIN 1550-AC42 Community Reinvestment Act...

  6. 78 FR 79283 - Community Reinvestment Act Regulations

    Science.gov (United States)

    2013-12-30

    ... by reference to asset-size criteria expressed in dollar amounts, and they further require the....C. 553(b)(B) of the Administrative Procedure Act (APA), an agency may, for good cause, find (and.... Under 5 U.S.C. 553(d)(3) of the APA, the required publication or service of a substantive rule shall be...

  7. 13 CFR 102.36 - Privacy Act standards of conduct.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Privacy Act standards of conduct. 102.36 Section 102.36 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RECORD DISCLOSURE... existence or development of any system of records that is not the subject of a current or planned public...

  8. Preschools Under the Fair Labor Standards Act, July 1972.

    Science.gov (United States)

    Employment Standards Administration (DOL), Washington, DC. Wage and Hour Div.

    This pamphlet provides general information concerning the application of the Fair Labor Standards Act to employees of preschool centers. Included is a discussion of: (1) Basic Monetary Requirements, including minimum wages and facilities furnished to the preschool employees, (2) Equal Pay Provisions, (3) Overtime, (4) Hours Worked, (5) Exemptions,…

  9. 75 FR 35686 - Community Reinvestment Act Regulation Hearings

    Science.gov (United States)

    2010-06-23

    ... will post comments on the OTS Internet Site at http://www.ots.treas.gov/?p=LawsRegulations . Viewing... consider violations of additional consumer laws, such as the Truth in Savings Act, the Electronic Fund...

  10. 13 CFR 107.30 - Amendments to Act and regulations.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Amendments to Act and regulations. 107.30 Section 107.30 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS... subject to all existing and future provisions of the Act and parts 107 and 112 of title 13 of the Code of...

  11. Black Lung Benefits Act: standards for chest radiographs. Direct final rule; request for comments.

    Science.gov (United States)

    2013-06-13

    Physicians and adjudicators use chest radiographs (X-rays) as a tool in evaluating whether a coal miner suffers from pneumoconiosis (black lung disease). Accordingly, the Department's regulations implementing the Black Lung Benefits Act allow the submission of radiographs in connection with benefit claims and set out quality standards for their performance. These standards are currently limited to film radiographs. In recent years, many medical facilities have phased out film radiography in favor of digital radiography. This direct final rule updates the existing film-radiograph standards and provides parallel standards for digital radiographs. This rule also updates outdated terminology and removes certain obsolete provisions.

  12. 75 FR 53153 - Federal Acquisition Regulation; American Recovery and Reinvestment Act of 2009 (the Recovery Act...

    Science.gov (United States)

    2010-08-30

    ... States would not fully implement section 1605 of the Recovery Act. Section 1605 singled out iron and... statute and how best to convey these requirements in the regulations. Because iron and steel are singled...

  13. 78 FR 32595 - Revision of Freedom of Information Act Regulation

    Science.gov (United States)

    2013-05-31

    ... Revision of Freedom of Information Act Regulation AGENCY: Office of the Secretary, HUD. ACTION: Proposed rule. SUMMARY: This proposed rule would amend HUD's regulations implementing the Freedom of Information... with speech or hearing impairments may access this number via TTY by calling the toll-free Federal...

  14. Minimum Wage and Maximum Hours Standards Under the Fair Labor Standards Act. Economic Effects Studies.

    Science.gov (United States)

    Wage and Labor Standards Administration (DOL), Washington, DC.

    This report describes the 1966 amendments to the Fair Labor Standards Act and summarizes the findings of three 1969 studies of the economic effects of these amendments. The studies found that economic growth continued through the third phase of the amendments, beginning February 1, 1969, despite increased wage and hours restrictions for recently…

  15. A study on how to divide and recodify the atomic energy act and its related regulations

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Hui; Chung, Sang Ki; Lee, Sang Soo [Hannam Univ., Taejon (Korea, Republic of); Myung, Jae Jin [Chungnam National Univ., Taejon (Korea, Republic of)

    2003-02-15

    As a part of big project named 'streamlining and optimization of nuclear safety regulatory system', this report focuses on how to divide and recodify the Atomic Energy Act and its related regulations. Follow the first chapter of preface, the second chapter shows the systemic problems of regulation of current AEA and out strategy to reform and re-systematize it. This report concludes that the regulations of the current AEA need to be divided in three parts, i.e. the presidential regulations of FWAAE, NNA and RPA and the ministerial regulation of AEA in two part, i.e. that of NNA and RPA. Then the problems of current regulations of AEA are pointed out and the alternative regulations of FWAAE and NNA are persented in the third and forth chapter respectively. In the fifth chapter RPA is persented. And finally the legal character of several nuclear safety standards is estimated. Concerning nuclear safety or technology standards, those issued by Minister of Science and Technology (MST) empowered by law or its regulation is obviously forceful as a law. But the standards made by KINS to meet the tasks entrusted to KINS by MST is only conditionally forceful as a law, that is, on the condition that law or regulation empowered the chief of KINS to make nuclear safety and/or technology standards.

  16. Microcomputer relay regulator in the CAMAC standard

    International Nuclear Information System (INIS)

    Nikolaev, V.P.

    1984-01-01

    The digital relay regulator is developed on the base of the KM001 microcomputer and KK06 controller for automatic control ob ects with transfer functions describing a broad class of systems using actuating motors (stabilitation, follow-up systems). The CAMAC relay-unit realizes the regulation law and provides the possibility to control analogous values by 8 channels

  17. Review of codes, standards, and regulations for natural gas locomotives.

    Science.gov (United States)

    2014-06-01

    This report identified, collected, and summarized relevant international codes, standards, and regulations with potential : applicability to the use of natural gas as a locomotive fuel. Few international or country-specific codes, standards, and regu...

  18. The general technical regulation and the standardization

    International Nuclear Information System (INIS)

    Laverie, Michel; Houze, Christian; Lebouleux, Philippe

    1980-01-01

    Through a certain number of procedures, the thorough appreciation of the safety of a nuclear installation relies more on a specific appreciation taking into account the references as a whole, than on a technical regulation which claims to cover all the problems. Nevertheless, a French technical regulation structure regarding the safety domain must be built up progressively. The authors consider the principles of such a structure, and together they make the inventory of the works, finished, in progress or contemplated. The description of this specifically French approach emphazises the multiple and complementary forms given to statutory implements [fr

  19. 75 FR 49363 - Deposit Insurance Regulations; Permanent Increase in Standard Coverage Amount; Advertisement of...

    Science.gov (United States)

    2010-08-13

    ... Insurance Regulations; Permanent Increase in Standard Coverage Amount; Advertisement of Membership... Procedure Act The FDIC believes that good cause exists for issuing the final rule without providing an... the public interest.'' \\8\\ The FDIC also finds good cause for issuing the final rule without a 30-day...

  20. Outlines of revised regulation standards for experimental research reactors

    International Nuclear Information System (INIS)

    Hohara, Shinya

    2015-01-01

    In response to the accident of TEPCO Fukushima Daiichi Nuclear Power Station, the government took actions through the revision of regulatory standards as well as the complete separation of regulation administrative department from promotion administrative department. The Nuclear and Industrial Safety Agency of the Ministry of Economy, Trade and Industry, which has been in charge of the regulations of commercial reactors, and the Office of Nuclear Regulations of the Ministry of Education, Culture, Sports, Science and Technology, which has been in charge of the regulations of reactors for experiment and research, were separated from both ministries, and integrated into the Nuclear Regulation Authority, which was newly established as the affiliated agency of the Ministry of the Environment. As for the revision of regulations and standards, the Nuclear Safety Commission was dismantled, and regulation enacting authority was given to the new Nuclear Regulation Authority, and the regulations that stipulated new regulatory standards were enacted. This paper outlines the contents of regulations related mainly to the reactors for experiment and research, and explains the following: (1) retroactive application of the new regulatory standards to existing reactor facilities, (2) examinations at the Nuclear Regulatory Agency, (3) procedures to confirm the compliance to the new standards, (4) seismic design classification, and (5) importance classification of safety function. (A.O.)

  1. Regulations under the Radiation Protection and Control Act, 1982, No. 221 of 1984

    International Nuclear Information System (INIS)

    1984-01-01

    These Regulations made under the Radiation Protection and Control Act of 1982, amend several numerical quotations contained in the Radiation Safety (Transport) Regulations, No. 27, 1984, also made under the above mentioned Act. (NEA) [fr

  2. 78 FR 53645 - Black Lung Benefits Act: Standards for Chest Radiographs

    Science.gov (United States)

    2013-08-30

    ...-AA07 Black Lung Benefits Act: Standards for Chest Radiographs AGENCY: Office of Workers' Compensation... connection with claims filed under the Black Lung Benefits Act. The comment period closed on August 12, 2013..., 2013, OWCP published the direct final rule, Black Lung Benefits Act: Standards for Chest Radiographs...

  3. 77 FR 74546 - Posting of Pamphlet Provided for in the International Marriage Broker Regulation Act

    Science.gov (United States)

    2012-12-14

    ... Marriage Broker Regulation Act ACTION: Notice of posting of pamphlet provided for in section 833(a) of the International Marriage Broker Regulation Act, Title D of Public Law 109-162. SUMMARY: Section 833(a) of the International Marriage Broker Regulation Act, Title D of Public Law 109-162, provided that the Secretary of...

  4. Developments in safety standards and regulation

    International Nuclear Information System (INIS)

    Harbison, S.A.

    1994-01-01

    This paper explains, in broad terms, how regulatory control is exercised over licensed nuclear installations in the UK and how HSE has developed its safety standards to support its regulatory approach. It first sets out the scope of HSE's regulatory responsibilities, which NII exercises on its behalf, and briefly describes the licensing process and compliance monitoring through inspection over the life of a nuclear plant. It also refers to the role of assessment in NII's decision-making processes, and the part played in this by the consideration of costs and safety benefits. It then moves on to consider the challenges that HSE/NII are likely to face from the changing nuclear industry in the second half of the 1990s. (author)

  5. Clean Air Act Guidelines and Standards for Waste Management

    Science.gov (United States)

    This page contains the stationary sources of air pollution for the waste management industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  6. Clean Air Act Standards and Guidelines for Electric Utilities

    Science.gov (United States)

    This page contains the stationary sources of air pollution for theelectric utilitiesr industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  7. Clean Air Act Standards and Guidelines for Sterilizers

    Science.gov (United States)

    This page contains the stationary sources of air pollution for the sterilizer industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  8. Clean Air Act Standards and Guidelines for Mineral Processing

    Science.gov (United States)

    This page contains the stationary sources of air pollution for the mineral processing industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  9. Environmental impact assessment modern dressed? To the amendment of the EIA act and other acts and regulations

    International Nuclear Information System (INIS)

    Feldmann, Ulrike

    2017-01-01

    On 22 December 2016, the Federal Ministry for the Environment (BMUB) presented the ''Draft Act for the Modernization of the Act on the Environmental Impact Assessment'' within the framework of the association consultation, as well as the ''Draft first Ordinance Amending the Ordinance on the Approval Procedure - 9. BImSchV''. The EIA Modernization Act as well as the Atomic Act Procedure Regulation and the Federal Mining Act should be revised by terms of an omnibus act. The association consultation was held on 18 January 2017.

  10. Adaptive Equilibrium Regulation: A Balancing Act in Two Timescales

    Science.gov (United States)

    Boker, Steven M.

    2015-01-01

    An equilibrium involves a balancing of forces. Just as one maintains upright posture in standing or walking, many self-regulatory and interpersonal behaviors can be framed as a balancing act between an ever changing environment and within-person processes. The emerging balance between person and environment, the equilibria, are dynamic and adaptive in response to development and learning. A distinction is made between equilibrium achieved solely due to a short timescale balancing of forces and a longer timescale preferred equilibrium which we define as a state towards which the system slowly adapts. Together, these are developed into a framework that this article calls Adaptive Equilibrium Regulation (ÆR), which separates a regulatory process into two timescales: a faster regulation that automatically balances forces and a slower timescale adaptation process that reconfigures the fast regulation so as to move the system towards its preferred equilibrium when an environmental force persists over the longer timescale. This way of thinking leads to novel models for the interplay between multiple timescales of behavior, learning, and development. PMID:27066197

  11. 78 FR 55171 - Removal of Standards of Ethical Conduct Regulations

    Science.gov (United States)

    2013-09-10

    ... Ethical Conduct Regulations AGENCY: Special Inspector General for Iraq Reconstruction. ACTION: Final rule... concurrence of the Office of Government Ethics (OGE), issued a final rule for employees of the SIGIR that supplemented the executive-branch-wide Standards of Ethical Conduct (Standards) issued by OGE. With certain...

  12. Employee Retirement Income Security Act of 1974: rules and regulations for administration and enforcement; claims procedure. Pension and Welfare Benefits Administration, Labor. Final regulation.

    Science.gov (United States)

    2000-11-21

    This document contains a final regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). The regulation establishes new standards for the processing of claims under group health plans and plans providing disability benefits and further clarifies existing standards for all other employee benefit plans. The new standards are intended to ensure more timely benefit determinations, to improve access to information on which a benefit determination is made, and to assure that participants and beneficiaries will be afforded a full and fair review of denied claims. When effective, the regulation will affect participants and beneficiaries of employee benefit plans, employers who sponsor employee benefit plans, plan fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  13. A Study of the Relationship between the ACT College Mathematics Readiness Standard and College Mathematics Achievement

    Science.gov (United States)

    Harwell, Michael; Moreno, Mario; Post, Thomas

    2016-01-01

    This study examined the relationship between the American College Testing (ACT) college mathematics readiness standard and college mathematics achievement using a sample of students who met or exceeded the minimum 3 years high school mathematics coursework recommended by ACT. According to ACT, a student who scores 22 or higher on the ACT…

  14. 20 CFR 626.3 - Purpose, scope, and applicability of the Job Training Partnership Act regulations.

    Science.gov (United States)

    2010-04-01

    ... ADMINISTRATION, DEPARTMENT OF LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.3 Purpose, scope, and applicability of the Job Training Partnership Act regulations. (a) Parts 626..., part C of the Job Training Partnership Act) establish the Federal programmatic and administrative...

  15. 45 CFR 2543.84 - Contract Work Hours and Safety Standards Act.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Contract Work Hours and Safety Standards Act. 2543... OTHER NON-PROFIT ORGANIZATIONS Statutory Compliance § 2543.84 Contract Work Hours and Safety Standards Act. Where applicable, all contracts awarded by recipients in excess of $2000 for construction...

  16. 48 CFR 52.222-43 - Fair Labor Standards Act and Service Contract Act-Price Adjustment (Multiple Year and Option...

    Science.gov (United States)

    2010-10-01

    ... and Service Contract Act-Price Adjustment (Multiple Year and Option Contracts). 52.222-43 Section 52... Standards Act and Service Contract Act—Price Adjustment (Multiple Year and Option Contracts). As prescribed in 22.1006(c)(1), insert the following clause: Fair Labor Standards Act and Service Contract Act...

  17. 7 CFR 27.95 - Spot markets to conform to Act and regulations.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Spot markets to conform to Act and regulations. 27.95 Section 27.95 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... and Differences § 27.95 Spot markets to conform to Act and regulations. Every bona fide spot market...

  18. Statistical benchmarking in utility regulation: Role, standards and methods

    International Nuclear Information System (INIS)

    Newton Lowry, Mark; Getachew, Lullit

    2009-01-01

    Statistical benchmarking is being used with increasing frequency around the world in utility rate regulation. We discuss how and where benchmarking is in use for this purpose and the pros and cons of regulatory benchmarking. We then discuss alternative performance standards and benchmarking methods in regulatory applications. We use these to propose guidelines for the appropriate use of benchmarking in the rate setting process. The standards, which we term the competitive market and frontier paradigms, have a bearing on method selection. These along with regulatory experience suggest that benchmarking can either be used for prudence review in regulation or to establish rates or rate setting mechanisms directly

  19. International Safety Regulation and Standards for Space Travel and Commerce

    Science.gov (United States)

    Pelton, J. N.; Jakhu, R.

    The evolution of air travel has led to the adoption of the 1944 Chicago Convention that created the International Civil Aviation Organization (ICAO), headquartered in Montreal, Canada, and the propagation of aviation safety standards. Today, ICAO standardizes and harmonizes commercial air safety worldwide. Space travel and space safety are still at an early stage of development, and the adoption of international space safety standards and regulation still remains largely at the national level. This paper explores the international treaties and conventions that govern space travel, applications and exploration today and analyzes current efforts to create space safety standards and regulations at the national, regional and global level. Recent efforts to create a commercial space travel industry and to license commercial space ports are foreseen as means to hasten a space safety regulatory process.

  20. Statutory Instrument No. 2056, The Nuclear Installations Act 1965 etc. (Repeals and Modifications) Regulations 1974

    International Nuclear Information System (INIS)

    1975-01-01

    These Regulations contain repeals and modifications of provisions of the Nuclear Installations Act 1965 and a modification of the Nuclear Installations (Dangerous Occurrences) Regulations 1965. They are made in consequence of the establishment on 1st January 1975 of the Health and Safety Executive and the coming into operation on that date of provisions of the Health and Safety at Work etc. Act 1974 which supersede or affect provisions of the 1965 Act and the 1965 Regulations. (NEA) [fr

  1. Charging scheme for Radioactive Substances Act regulation 1998-1999

    International Nuclear Information System (INIS)

    1998-03-01

    The Environment Act 1995 provides for the Environment Agency ('the Agency') to recover the costs and expenses incurred by the Agency and by the Minister of Agriculture, Fisheries and Food (MAFF) in carrying out their functions in relation to the Radioactive Substances Act 1993 ('the Act'). The Act deals with the keeping and use of radioactive substances, and with the accumulation and disposal of radioactive waste

  2. 76 FR 72132 - Regulations Under The Fur Products Labeling Act

    Science.gov (United States)

    2011-11-22

    ... then suggests issues for discussion at the hearing. A. Fur Act and Rules The Fur Act prohibits..., fleece, and fur-bearing animals.'' \\9\\ The Act further requires these names to ``be the true English names for the animals in question, or in the absence of a true English name for an animal, the name by...

  3. A German perspective on advances in safety standards and regulations

    International Nuclear Information System (INIS)

    Berg, H.P.; Herttrich, P.M.

    1993-01-01

    At present, different proposals for evolutionary or innovative reactors are under consideration. Therefore, it is necessary that the regulators give guidance on the required safety characteristics of future designs of nuclear power plants. On the one hand, existing regulations have to be updated according to the current state of science and technology. Best available and adequately approved technology has to be used as a yardstick for the acceptability of future basic design features. On the other hand, potential safety features of innovative or revolutionary designs must be considered as serious competitors and potential technical solutions taking the state of maturity of the concepts, the extent of practical experience and the level of effort needed for realization into due account. On this background, recent developments of the Atomic Energy Act, of safety regulations and investigations of requirements for future designs in the Federal Republic of Germany and current projects of international cooperation are presented. (author)

  4. 78 FR 12833 - Patient Protection and Affordable Care Act; Standards Related to Essential Health Benefits...

    Science.gov (United States)

    2013-02-25

    ... wellness services and chronic disease management; and pediatric services, including oral \\8\\ and vision... Act uses the terms ``dental'' and ``oral'' interchangeably when referring to the pediatric dental care... Parts 147, 155, and 156 Patient Protection and Affordable Care Act; Standards Related to Essential...

  5. Incorporating Lean Construction agent into the Building Standards Act: the Spanish case study

    Directory of Open Access Journals (Sweden)

    Brioso Xavier

    2016-12-01

    Full Text Available There is a demand for lean construction in Europe; even though lean construction is still an emerging field and there is growing interest, there are no regulations on this topic. The main objective of this research is to regulate this role when in a project and to define and develop a building agent structure, according to the Building Standards Act (LOE by its acronym in Spanish, to be able to incorporate it into the Spanish law, protecting it from civil liabilities. In Spain, there is jurisprudence in civil jurisdiction based on the LOE to acquit or convict building agents, who are defined in the courts as “constructive managers” or similar. For this reason, courts could establish in the future several liabilities for the lean construction specialist and other agents of the project, depending on their actions and based on the implementation of the lean project delivery system, the target value design and the integrated project delivery. Conversely, it is possible that the level of action of the lean construction specialist may comprise design management, construction management and contract management. Accordingly, one or more building agents should be appropriately incorporated into the LOE according to their functions and responsibilities and based on the levels of action of the lean construction specialist. The creation of the following agents is proposed: design manager, construction manager and contract manager, definitions that are developed in this study. These agents are loosely defined, because any project manager, building information modeling manager or similar may act as one or as more-than-one of them. Finally, the creation of the lean construction manager is also proposed, as the agent who takes on the role of the design manager, construction manager and contract manager, but focused on the lean production principles.

  6. Merits and difficulties in adopting codes, standards and nuclear regulations

    International Nuclear Information System (INIS)

    El-Saiedi, A.F.; Morsy, S.; Mariy, A.

    1978-01-01

    Developing countries planning for introducing nuclear power plants as a source of energy have to develop or adopt sound regulatory practices. These are necessary to help governmental authorities to assess the safety of nuclear power plants and to perform inspections needed to confirm the established safe and sound limits. The first requirement is to form an independent regulatory body capable of setting up and enforcing proper safety regulations. The formation of this body is governed by several considerations related to local conditions in the developing countries, which may not always be favourable. It is quite impractical for countries with limited experience in the nuclear power field to develop their own codes, standards and regulations required for the nuclear regulatory body to perform its tasks. A practical way is to adopt codes, standards and regulations of a well-developed country. This has merits as well as drawbacks. The latter are related to problems of personnel, software, equipment and facilities. The difficulties involved in forming a nuclear regulatory body, and the merits and difficulties in adopting foreign codes, standards and regulations required for such body to perform its tasks, are discussed in this paper. Discussions are applicable to many developing countries and particular emphasis is given to the conditions and practices in Egypt. (author)

  7. 76 FR 78977 - Real Estate Settlement Procedures Act (Regulation X)

    Science.gov (United States)

    2011-12-20

    ... 1061 of the Dodd-Frank Act transferred to the Bureau all of the HUD Secretary's consumer protection... a ``creditor'', as defined in section 103(g) of the Consumer Credit Protection Act (15 U.S.C. 1602(g... Vol. 76 Tuesday, No. 244 December 20, 2011 Part II Bureau of Consumer Financial Protection 12 CFR...

  8. 20 CFR 626.2 - Format of the Job Training Partnership Act regulations.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Format of the Job Training Partnership Act regulations. 626.2 Section 626.2 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR INTRODUCTION TO THE REGULATIONS UNDER THE JOB TRAINING PARTNERSHIP ACT § 626.2 Format of the Job...

  9. 77 FR 19455 - Regulations Implementing the Byrd Amendments to the Black Lung Benefits Act: Determining Coal...

    Science.gov (United States)

    2012-03-30

    ... Programs 20 CFR Parts 718 and 725 Regulations Implementing the Byrd Amendments to the Black Lung Benefits... Implementing the Byrd Amendments to the Black Lung Benefits Act: Determining Coal Miners' and Survivors... amendments to the Black Lung Benefits Act (BLBA or Act) made by the Patient Protection and Affordable Care...

  10. 78 FR 60686 - Regulations Implementing the Byrd Amendments to the Black Lung Benefits Act: Determining Coal...

    Science.gov (United States)

    2013-10-02

    ...-AA04 Regulations Implementing the Byrd Amendments to the Black Lung Benefits Act: Determining Coal... correcting the preamble to a final rule implementing amendments to the Black Lung Benefits Act that appeared... the Byrd Amendments to the Black Lung Benefits Act: Determining Coal Miners' and Survivors...

  11. 77 FR 29982 - Federal Acquisition Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment...

    Science.gov (United States)

    2012-05-21

    ...; Submission for OMB Review; Davis Bacon Act-Price Adjustment (Actual Method) AGENCY: Department of Defense... previously approved information collection requirement concerning the Davis-Bacon Act price adjustment... Bacon Act-Price Adjustment (Actual Method), by any of the following methods: Regulations.gov : http...

  12. 1990 No. 1918. The Nuclear Installations Act 1965 (Repeal and Modifications) Regulations 1990

    International Nuclear Information System (INIS)

    1990-01-01

    These Regulations entered into force on 31 October 1990. They repeal part of Section (1) of the Nuclear Installations Act 1965 to remove the exemption of the United Kingdom Atomic Energy Authority (UKAEA) from licensing under the Act. The Regulations also amend the 1965 Act to ensure that the UKAEA's duties in respect of the safety of premises it occupies will continue to apply whether or not a nuclear site licence has been granted. (NEA) [fr

  13. Regulations and standardization relative to the biomass combustion

    International Nuclear Information System (INIS)

    Autret, E.

    2009-01-01

    It does not exist regulations on pollutants emissions on domestic wood burning furnaces, however, these appliances are submitted to the European and french standardization concerning the safety rules, the use rules and the tests methods. Since 2007, these wood burning appliances on the market must have the European Community label. The green flame label was elaborated by the environment and energy control Agency (A.D.E.M.E.), and manufacturers of domestic appliances to promote the use of competitive wood burning appliances. concerning the collective and industrial heating, the installations of more 2 MW are framed by different categories of the installations classified for environment protection (I.C.P.E.) regulation according their fuel and power. The combustion installations of less than 2 MW are a particular case, they are framed by a sanitary department regulation and are controlled by the department directions of sanitary and social affairs. the limit values of emissions are summarized in tables. (N.C.)

  14. 76 FR 15342 - Workforce Investment Act; Lower Living Standard Income Level

    Science.gov (United States)

    2011-03-21

    ... Standard Income Level AGENCY: Employment and Training Administration, Labor. ACTION: Notice of determination of Lower Living Standard Income Level. SUMMARY: Under Title I of the Workforce Investment Act (WIA... Income level (LLSIL) for uses described in the law. WIA defines the term ``Low Income Individual'' as one...

  15. 75 FR 25296 - Workforce Investment Act; Lower Living Standard Income Level

    Science.gov (United States)

    2010-05-07

    ... Standard Income Level AGENCY: Employment and Training Administration, Labor. ACTION: Notice of Determination of Lower Living Standard Income Level. SUMMARY: Under Title I of the Workforce Investment Act (WIA... Income Level (LLSIL) for uses described in the law. WIA defines the term ``Low Income Individual'' as one...

  16. 75 FR 48585 - Revision of Freedom of Information Act Regulations

    Science.gov (United States)

    2010-08-11

    ... the initial publication of CEQ's FOIA regulations in 1977, reflects the increased cost of human..., CEQ has adhered to the regulatory philosophy and the applicable principles of regulation as set forth... significantly affecting the quality of the human environment.'' If an action may have a significant impact and...

  17. 77 FR 74347 - Freedom of Information Act Regulations

    Science.gov (United States)

    2012-12-14

    ... regulation, CIGIE adhered to the regulatory philosophy and the applicable principles of regulation as set... research (if the request is from an educational institution) or scientific research (if the request is from... operating one or more programs of scholarly research. (2) The term ``non-commercial scientific institution...

  18. ASPECTS CONCERNING INTERIM FINANCIAL REPORTING IN ROMANIA: STANDARDS AND REGULATIONS

    Directory of Open Access Journals (Sweden)

    Aristita Rotila

    2014-12-01

    Full Text Available The mechanisms employed for the communication of accounting information that is necessary for users in their economic decision-making process consist of the financial statements of an entity. All legal entities, no matter the domain of their activity, have the obligation to draw up annual financial statements for every completed financial year. For certain categories of entities, reporting obligations are also required for periods other than the annual reporting, throughout the financial year. It is the case of interim financial reporting. At the level of the international accounting framework, the aspects related to interim financial reporting are the subject of a separate standard, namely, IAS 34 Interim Financial Reporting. In Romania, the current system of accounting regulations concerning the annual financial statements comprises accounting regulations that comply with the European directives and which apply to the various categories of entities, on the one hand and, on the other, accounting regulations in line with the IFRS, which are applicable to other classes of entities from certain activity sectors. The accounting regulations that apply to each category refer to, among other things, the contents and the format of financial statements that have to be presented. Analysing the system of norms and regulations, this article identifies the requirements concerning interim financial reporting in Romania, with reference to the different types of entities.

  19. The United States Board on Geographic Names: Standardization or regulation?

    Science.gov (United States)

    Payne, R.L.

    2000-01-01

    The United States Board on Geographic Names was created in 1890 to standardize the use of geographic names on federal maps and documents, and was established in its present form in 1947 by public law. The Board is responsible for geographic name usage and application throughout the federal government and its members must approve a name change or new name before it can be applied to federal maps and publications. To accomplish its mission, the Board has developed principles, policies, and procedures for use in the standardization process. The Board is also responsible legally for the promulgation of standardized names, whether or not these names have ever been controversial, and today this is accomplished by the universal availability of electronic databases for domestic and foreign names. This paper examines the development of Board policies and the implementation of these policies to achieve standardization with a view to relating these policies and activities to questions of standardization or regulation. ?? 2000 by The American Name Society.

  20. 75 FR 41370 - Regulations Implementing the Freedom of Information Act

    Science.gov (United States)

    2010-07-16

    ... updates paragraph (a) to reflect the new maintenance of statistics requirements in the OPEN Government Act... 2201.4 is amended: 0 a. By revising paragraphs (c) introductory text, (c)(1), (3), (4), and (5); 0 b...) introductory text; 0 b. Adding paragraph (b)(2)(v); and 0 c. Revising paragraph (e). The revisions and addition...

  1. 75 FR 22320 - Regulations Implementing the Freedom of Information Act

    Science.gov (United States)

    2010-04-28

    ... reflect the new maintenance of statistics requirements in the OPEN Government Act. 5 U.S.C. 552(e). III... 2201.4 is amended: a. By revising paragraphs (c) introductory text, (c)(1), (3), (4), and (5); b. By.... Revising paragraphs (b)(1) and (b)(2) introductory text; b. Adding paragraph (b)(2)(v); and c. Revising...

  2. 77 FR 50390 - Equal Credit Opportunity Act (Regulation B)

    Science.gov (United States)

    2012-08-21

    ..., such as account numbers or social security numbers, should not be included. Comments will not be edited... most severe U.S. recession since the Great Depression.\\6\\ The Dodd-Frank Act created the Bureau and... other similar media. In addition, the proposed comment clarifies that creditors should look to Sec. 1002...

  3. Radioactive Substances Regulations, 1959 under the Radioactive Substances Act 1957

    International Nuclear Information System (INIS)

    1983-01-01

    These Regulations as amended lay down maximum permissible concentrations and doses and prescribe radiation protection measures for personnel. They provide for the licensing procedures for radioactive materials and irradiating apparatus and the conditions to be complied with for their handling, packaging, transport and disposal. The Schedules to the Regulations contain tables of maximum permissible radionuclide concentrations, models of licence application forms and labels. (NEA) [fr

  4. Gasoline risk management: a compendium of regulations, standards, and industry practices.

    Science.gov (United States)

    Swick, Derek; Jaques, Andrew; Walker, J C; Estreicher, Herb

    2014-11-01

    This paper is part of a special series of publications regarding gasoline toxicology testing and gasoline risk management; this article covers regulations, standards, and industry practices concerning gasoline risk management. Gasoline is one of the highest volume liquid fuel products produced globally. In the U.S., gasoline production in 2013 was the highest on record (API, 2013). Regulations such as those pursuant to the Clean Air Act (CAA) (Clean Air Act, 2012: § 7401, et seq.) and many others provide the U.S. federal government with extensive authority to regulate gasoline composition, manufacture, storage, transportation and distribution practices, worker and consumer exposure, product labeling, and emissions from engines and other sources designed to operate on this fuel. The entire gasoline lifecycle-from manufacture, through distribution, to end-use-is subject to detailed, complex, and overlapping regulatory schemes intended to protect human health, welfare, and the environment. In addition to these legal requirements, industry has implemented a broad array of voluntary standards and best management practices to ensure that risks from gasoline manufacturing, distribution, and use are minimized. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  5. 7 CFR 33.60 - OMB control number assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS REGULATIONS ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT...

  6. Radiation doses in pediatric radiology: influence of regulations and standards

    International Nuclear Information System (INIS)

    Suleiman, O.H.

    2004-01-01

    The benefits of X-ray examinations contribute to the quality of modern medicine; however the risk of using X-rays, a carcinogen, has always been a concern. This concern is heightened for pediatric patients, who have a much greater sensitivity to the carcinogenic effects of radiation than adults. The principle of as low as reasonably achievable, or ALARA, is essential for minimizing the radiation dose patients receive, especially for pediatric patients. In order to keep radiation doses ALARA, one must know the dose patients receive. The determination of radiation dose in a standard way is therefore necessary so that these doses can be compared with practice, and for meaningful comparison against voluntary standards. In extreme situations, where public health needs may require mandatory standards, or regulations, the quantitative measurement and calculation of radiation dose becomes essential. How some radiation dose metrics and standards have evolved, including the value of different metrics such as entrance air kerma, organ dose, and effective dose will be presented. Recent pediatric X-ray studies, whether or not dedicated pediatric equipment is necessary, and recent initiatives by the Food and Drug Administration for pediatric population will be discussed. (orig.)

  7. The radioactive waste regulation in the new Czech Nuclear Energy Act

    International Nuclear Information System (INIS)

    Kucerka, M.

    1995-01-01

    Recently, in the Czech Republic, there is in the phase of development the Act on Peaceful Use of Nuclear Energy and Ionizing Radiation, so called the Nuclear Energy Act. This Act has to replace existing regulations and fulfill some not yet covered fields of that area. The act is developed as so called ''umbrella act'' and has to cover all aspects of the nuclear energy and ionizing radiation use, from uranium mining or isotopes use in medicine, to the power generation in nuclear power plants. It will include among others also provisions on registration and licensing, liability for nuclear damage, decommissioning and radioactive waste management funding, and some other topics, that were missing in the regulations up to today. The paper describes recent state policy in the field of radioactive waste management and the main provisions of proposed Nuclear Energy Act, concerning the radioactive waste management

  8. 77 FR 29235 - Patient Protection and Affordable Care Act; Standards Related to Reinsurance, Risk Corridors, and...

    Science.gov (United States)

    2012-05-17

    ..., 2012. II. Summary of Error On page 17248, we inadvertently made an incorrect cross reference in the regulations text at Sec. 153.220(d). We are correcting the cross reference from ``Sec. 153.210(a)(2)(ii)'' to... effect in accordance with section 553(b) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b...

  9. Brightening up: the effect of the Physician Payment Sunshine Act on existing regulation of pharmaceutical marketing.

    Science.gov (United States)

    Gorlach, Igor; Pham-Kanter, Genevieve

    2013-01-01

    With the passage of the Physician Payment Sunshine Act as part of the federal health care reform law, pharmaceutical manufacturers are now required to disclose a wide range of payments made by manufacturers to physicians. We review current state regulation of pharmaceutical marketing and consider how the federal sunshine provision will affect existing marketing regulation. We analyze the legal and practical implications of the Physician Payment Sunshine Act. © 2013 American Society of Law, Medicine & Ethics, Inc.

  10. 77 FR 42673 - Freedom of Information Act Regulations

    Science.gov (United States)

    2012-07-20

    .... 552). In issuing this regulation, CIGIE adhered to the regulatory philosophy and the applicable... research (if the request is from an educational institution) or scientific research (if the request is from... operating one or more programs of scholarly research. (2) The term ``non-commercial scientific institution...

  11. Standards and guidelines should be rules between licensees and regulators

    International Nuclear Information System (INIS)

    Narabayashi, Tadashi

    2014-01-01

    The 2011 off the Pacific coast of Tohoku Pacific Earthquake and the Tsunami gave the serious damage to the Fukushima-Daiichi Nuclear Power Plants (NPPs). The accidents occurred in Unit 1, 2, 3 and 4. It is said that the height of tsunami attacked Fukushima NPP was more than 14m. After 50 minutes from the automatic shut-down, tsunami attacked the NPPs in Fukushima Daiichi NPPs. For example, the Unit 1 lost A/C power caused the loss of water injection function; it made the core meltdown and unusual increase of PCV pressure in the midnight of March 11th to 12th morning. Though the Unit one has the Isolation Condenser Core Cooling system, it was stopped by the operator to keep the cooling rate of 55degC/h. Finally, the isolation signal was transmitted from the control room to the motor driven isolation valves when the control room's battery discharged. It was the initiation of the core meltdown. The lessons from the accidents, we should improve the nuclear safety regulation through the innovation of regulatory rules and safety standards. Standards and guidelines should be rules between licensees and regulators. (author)

  12. 77 FR 202 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2012-01-03

    ... 9000-AM00 Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting... accounting standards owing to the Financial Accounting Standards Board's Accounting Standards Codification of Generally Accepted Accounting Principles. DATES: Effective Date: February 2, 2012. FOR FURTHER INFORMATION...

  13. Mining Act 1968-1983 with regulations and an index (compiled to 1 January, 1984)

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    This consolidation of the Queensland Mining Act covers the Mining Act 1968 - 1983, Mining Act Amendment Act 1971 (No.2) No.82: Mining Act Amendment Act 1980, No.13: Mining Acts Amendment Act of 1929, 20 Geo. 5 of No.35: Regulations. The Act is arranged in 13 parts. Part I. Preliminary; II. Meaning of Terms; III. Mining districts and mining fields; IV. Authorities conferring rights to mine and prospect - Division I. Miner's right; IA. Mining claim; II. Authority to prospect; III. Mining Lease; IV. Compensation for damage caused by mining on Crown land; V. Caveats: Part V. Mining on reserves, residence areas and business areas; Part VI. Constructions and carriage through, over, or under alien land; VII. Sludge abatement; VIII. Royalties; IX. Administration - Division I. Appointment of officers; II. Wardens courts; III. Special powers of wardens and wardens courts; IV. Appeals from wardens courts: Part X. General Provisions; XI. Regulations; XII. Mining on private land; XIII. Rights independent of this Act preserved: Schedule.

  14. Coal Mine Health and Safety Regulation 2006 under the Coal Mine Health and Safety Act 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-12-22

    The aim of the Act is to secure the health, safety and welfare of people in connection with coal operations (which include all places of work where coal is mined and certain other places). The Regulation contains provisions about the following matters: (a) places of work to which the Act does not apply, (b) duties relating to health, welfare and safety at coal operations, including the following: (i) the nomination of the operator of a coal operation and the provision of health and safety information for incoming operators, (ii) the contents of health and safety management systems for coal operations, (iii) major hazards and the contents of major hazard management plans for coal operations, (iv) duties relating to contractors, (v) the contents of management structures and emergency management systems for coal operations, escape and rescue plans and fire fighting plans and high risk activities, (c) notifications, including (i) notification of incidents, (ii) inquiries, (iii) notification of other matters to the Chief Inspector), (d) aspects of safety at coal operations, including the following: (i) controlled materials, plants and practices, (ii) coal dust explosion prevention and suppression, (iii) ventilation at coal operations, (iv) escape from coal operations, (v) the operation of transport at coal operations, (vi) surveys and certified plans, (vii) employment at coal operations, (e) the licensing of certain activities, (f) competence standards, (g) the Coal Competence Board, (h) check inspectors, (i) exemptions from provisions of this Regulation, (j) the following miscellaneous matters concerning coal mine health and safety: (i) the keeping of records and reporting, (ii) penalties, the review of decisions by the Administrative Decisions Tribunal, fees and charges, consultation, information and other miscellaneous matters, (k) savings and transitional provisions.

  15. 40 CFR 261.8 - PCB wastes regulated under Toxic Substance Control Act.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false PCB wastes regulated under Toxic... (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE General § 261.8 PCB wastes regulated under Toxic Substance Control Act. The disposal of PCB-containing dielectric fluid and electric...

  16. 76 FR 8989 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2011-02-16

    ... Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References AGENCIES... Acquisition Regulation (FAR) to update references to authoritative accounting standards owing to the Financial... Accounting Principles (GAAP) (``Codification of GAAP''). DATES: Interested parties should submit written...

  17. 78 FR 277 - Section 610 Review of NPDES Permit Regulation and Effluent Limitations Guidelines Standards for...

    Science.gov (United States)

    2013-01-03

    ..., Section 610 Review of NPDES Permit Regulation and Effluent Limitations Guidelines Standards for..., FRL-9764-8] Section 610 Review of NPDES Permit Regulation and Effluent Limitations Guidelines Standards for Concentrated Animal Feeding Operations (CAFOs); Extension of Comment Period AGENCY...

  18. Federal Act on Protection against Nuisances (BImSchG) and supplementing regulations. 11. ed.

    International Nuclear Information System (INIS)

    Hansmann, K.

    1993-01-01

    This handy booklet contains the BImSchG and related implementing regulations as well as the Technical Codes Clean Air and Noise Abatement. The contribution on the BImSchG explains the origin of the Act, the scope of application, its concept and principles. The contents of the Act is portrayed by emphasizing subject-related connections. Dealt with are also regulations for installations requiring licensing, the measurement of airborne pollution, stipulations concerning the area of installations and transport, as well as the regulation concerning the monitoring of airborne pollution in the Federal Republic of Germany. (orig.) [de

  19. Federal Act on Protection against Nuisances (BImSchG) and supplementing regulations. 9. ed.

    International Nuclear Information System (INIS)

    Hansmann, K.

    1992-01-01

    This handy booklet contains the BImSchG and related implementing regulations as well as the Technical Codes Clean Air and Noise Abatement. The contribution on the BImSchG explains the origin of the Act, the scope of application, its concept and principles. The contents of the Act is portrayed by emphasizing subject-related connections. Dealt with are also regulations for installations requiring licensing, the measurement of airborne pollution, stipulations concerning the area of installations and transport, as well as the regulation concerning the monitoring of airborne pollution in the Federal Republic of Germany. (orig.) [de

  20. Clean/alternative fueled fleet programs - 1990 Amendments to the Clean Air Act, the Colorado Air Pollution Prevention and Control Act, and Denver City and County regulations

    International Nuclear Information System (INIS)

    Bowles, S.L.; Manderino, L.A.

    1993-01-01

    Despite substantial regulations for nearly two decades, attainment of this ambient standards for ozone and carbon monoxide (CO) remain difficult goals to achieve, Even with of ozone precursors and CO. The 1990 Amendments to the Clean Air Act (CAA90) prescribe further reductions of mobile source emissions. One such reduction strategy is using clean fuels, such as methanol, ethanol, or other alcohols (in blends of 85 percent or more alcohol with gasoline or other fuel), reformulated gasoline or diesel, natural gas, liquified petroleum gas, hydrogen, or electricity. There are regulatory measures involving special fuels which will be required in areas heavily polluted with ozone and CO. The state of Colorado recently passed the 1992 Air Pollution Prevention and Control Act which included provisions for the use of alternative fuels which will be implemented in 1994. In addition to adhering to the Colorado state regulations, the city and county of Denver also have regulations pertaining to the use of alternative fuels in fleets of 10 or more vehicles. Denver's program began in 1992. This paper will address the issue of fleet conversion and its impact on industry in Colorado, and Denver in particular

  1. Off-road compression-ignition engine emission regulations under the Canadian Environmental Protection Act 1999 : guidance document

    International Nuclear Information System (INIS)

    2006-03-01

    This guide explained the requirements for Off-Road Compression Ignition Engine Emission Regulations established under the Canadian Environmental Protection Act. The regulations are enforced by Environment Canada, which authorizes and monitors the use of the national emissions mark. The regulations prescribe standards for off-road engines that operate as reciprocating, internal combustion engines, other than those that operate under characteristics similar to the Otto combustion cycle and that use a spark plug or other sparking device. The regulations apply to engines that are typically diesel-fuelled and found in construction, mining, farming and forestry machines such as tractors, excavators and log skidders. Four different types of persons are potentially affected by the regulations: Canadian engine manufacturers; distributors of Canadian engines or machines containing Canadian engines; importers of engines or machines for the purpose of sale; and persons not in companies importing engines or machines. Details of emission standards were presented, as well as issues concerning evidence of conformity, importing engines, and special engine cases. Compliance and enforcement details were reviewed, as well as applicable standards and provisions for emission control systems and defeat devices; exhaust emissions; crankcase and smoke emissions; and adjustable parameters. Details of import declarations were reviewed, as well as issues concerning defects and maintenance instructions. 4 tabs., 4 figs

  2. To recognize the use of international standards for making harmonized regulation of medical devices in Asia-pacific.

    Science.gov (United States)

    Anand, K; Saini, Ks; Chopra, Y; Binod, Sk

    2010-07-01

    'Medical Devices' include everything from highly sophisticated, computerized, medical equipment, right down to simple wooden tongue depressors. Regulations embody the public expectations for how buildings and facilities are expected to perform and as such represent public policy. Regulators, who develop and enforce regulations, are empowered to act in the public's interest to set this policy and are ultimately responsible to the public in this regard. Standardization contributes to the basic infrastructure that underpins society including health and environment, while promoting sustainability and good regulatory practice. The international organizations that produce International Standards are the International Electrotechnical Commission (IEC), the International Organization for Standardization (ISO), and the International Telecommunication Union (ITU). With the increasing globalization of markets, International Standards (as opposed to regional or national standards) have become critical to the trading process, ensuring a level playing field for exports, and ensuring that imports meet the internationally recognized levels of performance and safety. The development of standards is done in response to sectors and stakeholders that express a clearly established need for them. An industry sector or other stakeholder group typically communicates its requirement for standards to one of the national members. To be accepted for development, a proposed work item must receive a majority support of the participating members, who verify the global relevance of the proposed item. The regulatory authority (RA) should provide a method for the recognition of international voluntary standards and for public notification of such recognition. The process of recognition may vary from country to country. Recognition may occur by periodic publication of lists of standards that a regulatory authority has found will meet the Essential Principles. In conclusion, International standards

  3. Utilization of coal fly ash in construction in relation to regulations within the framework of the Dutch Soil Protection Act

    International Nuclear Information System (INIS)

    van der Sloot, H.A.

    1991-01-01

    In 1987, the Dutch Government passed the Soil Protection Act. Within the framework of this act aiming at reduction of soil pollution by anthropogenic activities, a number of regulations will be enforced. One of these is the Regulation for Construction Materials, which is intended to control environmental impacts resulting from the utilization of industrial residues in construction. The regulation will apply to all conventional materials used in construction and raw materials derived from waste materials. For effective enforcement of this regulation by 1992, a full set of well documented procedures are needed to cover such aspects as sampling, storage, analysis of solids and liquids, leaching, and evaluation of test results. These procedures should ultimately be available as national (NEN), or preferably internationally (CEN, ISO), agreed standard protocols. A coherent program of projects has been started in 1990 in association with the Dutch Normalization Institute to generate these protocols and initiate the necessary research activities. As a result of the new regulations, initiatives have been taken to certify industrial residues for certain applications. The utilization of coal combustion residues in construction is governed by certificates. Thus, quality control at the utilities is an integral part of coal fly ash utilization and marketing. For public acceptance of utilization of these materials, quality control and certification is an essential element along with demonstrations of proper performance in practice

  4. 78 FR 47215 - Petition to Amend Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears...

    Science.gov (United States)

    2013-08-05

    ... No. APHIS-2012-0107] Petition to Amend Animal Welfare Act Regulations To Prohibit Public Contact With... Inspection Service has received a petition requesting amendments to the Animal Welfare Act regulations and...: Background The Animal Welfare Act (AWA, 7 U.S.C. 2131 et seq.) authorizes the Secretary of Agriculture to...

  5. Food safety regulations in Australia and New Zealand Food Standards.

    Science.gov (United States)

    Ghosh, Dilip

    2014-08-01

    Citizens of Australia and New Zealand recognise that food security is a major global issue. Food security also affects Australia and New Zealand's status as premier food exporting nations and the health and wellbeing of the Australasian population. Australia is uniquely positioned to help build a resilient food value chain and support programs aimed at addressing existing and emerging food security challenges. The Australian food governance system is fragmented and less transparent, being largely in the hands of government and semi-governmental regulatory authorities. The high level of consumer trust in Australian food governance suggests that this may be habitual and taken for granted, arising from a lack of negative experiences of food safety. In New Zealand the Ministry of Primary Industries regulates food safety issues. To improve trade and food safety, New Zealand and Australia work together through Food Standards Australia New Zealand (FSANZ) and other co-operative agreements. Although the potential risks to the food supply are dynamic and constantly changing, the demand, requirement and supply for providing safe food remains firm. The Australasian food industry will need to continually develop its system that supports the food safety program with the help of scientific investigations that underpin the assurance of what is and is not safe. The incorporation of a comprehensive and validated food safety program is one of the total quality management systems that will ensure that all areas of potential problems are being addressed by industry. © 2014 Society of Chemical Industry.

  6. Slovak Republic Act of 11 February 1998 on the energetics and on alterations to Act No. 455/1991 Collection of Acts of CSFR on small business (trade Act) in version of posterior regulations

    International Nuclear Information System (INIS)

    1998-01-01

    This act constitute: (a) conditions of undertaking in electro-energetic, gas industry, and heat supply (in next only 'energetic' branches) ; (b) rights and responsibility of physical and act person undertaking in energetic branches; (c) rights and responsibility of customers of electricity, gas, and heat; counteract measures in the need situations, (d) and at prevention before need situations in energetic branches; (e) state regulation in energetic; (f) authority on keep of this act. The act is divided into for parts: (1) General constitutions, (2) Energetic branches; (3) The state authority; (4) Common, transient and invalidation constitutions.This act deals with the specific conditions for undertaking in nuclear power plants, too (licensing, security). This act shall into effect on 1 July 1998

  7. 76 FR 37703 - Regulation of Fuels and Fuel Additives: 2012 Renewable Fuel Standards; Public Hearing

    Science.gov (United States)

    2011-06-28

    ... Regulation of Fuels and Fuel Additives: 2012 Renewable Fuel Standards; Public Hearing AGENCY: Environmental... hearing to be held for the proposed rule ``Regulation of Fuels and Fuel Additives: 2012 Renewable Fuel... be proposing amendments to the renewable fuel standard program regulations to establish annual...

  8. [Guidelines for certification of Activated clotting time (ACT) according to the EN ISO 22870 standards].

    Science.gov (United States)

    Lasne, Dominique; Bauters, Anne; Le Querrec, Agnès; Bourdin, Carole; Voisin, Sophie

    2015-01-01

    Point of care testing (POCT) must comply with regulatory requirements according to standard EN ISO 22870, which identify biologists as responsible for POCT. Activated clotting time (ACT) is mandatory to monitor on whole blood, anticoagulation achieved by unfractionated heparin during cardiopulmonary bypass (CPB) or cardiac catheterization. This test has no equivalent in the laboratory. With the aim to help the multidisciplinary groups for POCT supervision when they have to analyse the wish of medical departments to use ACT and to help the biologists to be in accordance with the standard, we present the guidelines of the GEHT (Groupe d'étude d'hémostase et thrombose) subcommittee "CEC et Biologie délocalisée" for the certification of ACT. These guidelines are based on the SFBC guidelines for the certification of POCT and on the analysis of the literature to ascertain the justification of clinical need and assess the analytical performance of main analyzers used in France, as well as on a survey conducted with French and Belgian biologists.

  9. 75 FR 40754 - Government in the Sunshine Act Regulations of the National Science Board

    Science.gov (United States)

    2010-07-14

    ... NATIONAL SCIENCE FOUNDATION 45 CFR Part 614 RIN 3145-AA53 Government in the Sunshine Act Regulations of the National Science Board AGENCY: National Science Board (NSB), National Science Foundation (NSF). ACTION: Direct final rule. SUMMARY: The National Science Board (NSB) National Science Foundation...

  10. 76 FR 20569 - Horse Protection Act; Petition for Amendments to Regulations

    Science.gov (United States)

    2011-04-13

    ... of Cruelty to Animals, the American Horse Protection Association, Inc., Friends of Sound Horses, Inc... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service 9 CFR Part 11 [Docket No. APHIS-2011-0006] Horse Protection Act; Petition for Amendments to Regulations AGENCY: Animal and Plant...

  11. 76 FR 78483 - S.A.F.E. Mortgage Licensing Act (Regulations G & H)

    Science.gov (United States)

    2011-12-19

    ... BUREAU OF CONSUMER FINANCIAL PROTECTION 12 CFR Part 1007 and 1008 [Docket No. CFPB-2011-0023] RIN 3170-AA06 S.A.F.E. Mortgage Licensing Act (Regulations G & H) AGENCY: Bureau of Consumer Financial... number of consumer financial protection laws from seven Federal agencies to the Bureau of Consumer...

  12. 76 FR 82117 - Regulations Implementing the Longshore and Harbor Workers' Compensation Act: Recreational Vessels

    Science.gov (United States)

    2011-12-30

    ... activity, and whether it falls within the Coast Guard definition of a non- recreational vessel less than 20... recreational vessel work, the employee will be eligible for benefits based on the covered work. The last... Regulations Implementing the Longshore and Harbor Workers' Compensation Act: Recreational Vessels AGENCY...

  13. 18 CFR 1300.101 - Cross references to employee ethical conduct standards and other applicable regulations.

    Science.gov (United States)

    2010-04-01

    ... employee ethical conduct standards and other applicable regulations. 1300.101 Section 1300.101 Conservation... TENNESSEE VALLEY AUTHORITY § 1300.101 Cross references to employee ethical conduct standards and other...-wide standards of ethical conduct at 5 CFR part 2635 and to the TVA regulations at 5 CFR part 7901...

  14. 1 CFR 21.14 - Deviations from standard organization of the Code of Federal Regulations.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Deviations from standard organization of the... CODIFICATION General Numbering § 21.14 Deviations from standard organization of the Code of Federal Regulations. (a) Any deviation from standard Code of Federal Regulations designations must be approved in advance...

  15. 77 FR 27550 - Federal Acquisition Regulation; Revision of Cost Accounting Standards Threshold

    Science.gov (United States)

    2012-05-10

    ...] RIN 9000-AM25 Federal Acquisition Regulation; Revision of Cost Accounting Standards Threshold AGENCY... Federal Acquisition Regulation (FAR) to revise the threshold for applicability of cost accounting standards in order to implement a recent rule of the Cost Accounting Standards Board and statutory...

  16. 29 CFR 550.1 - “Talent fees” as used in section 7(e)(3)(c) of the Fair Labor Standards Act, as amended.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âTalent feesâ as used in section 7(e)(3)(c) of the Fair...) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND DELIMITING THE TERM âTALENT FEESâ § 550.1 “Talent fees” as used in section 7(e)(3)(c) of the Fair Labor Standards Act, as amended. The...

  17. Standard regulation of obligatory immunoprevention of flu in a control system of incidence of health workers

    Directory of Open Access Journals (Sweden)

    A. E. Zobov

    2016-01-01

    Full Text Available In article the interconnected provisions of the federal legislation and regulations of federal executive authorities regulating a question of obligatory immunization of health workers against flu in aspect of legal consequences of refusal of her are considered. The analysis of the existing regulations and materials of jurisprudence concerning carrying out obligatory vaccination of health workers against flu is carried out. By results of the analysis it is shown that today a problematic issue is absence of the accurate standardly consolidated criteria of reference of these or those categories of medical personnel to group of the subjects of obligatory immunization performing works with sick infectious diseases and, respectively, against flu. It doesn’t allow the management of the medical organizations to differentiate specifically mentioned professions and positions owing to what the requirement about obligatory carrying out preventive inoculations against flu of those health workers whose obligatory vaccination isn’t provided actually is compulsion to vaccination. Therefore, the subsequent discharge from work in case of refusal it работни from carrying out an inoculation strikes at his rights (as in this case, for example, time of discharge isn’t subject to payment and inclusion in the length of service granting the right for the annual paid vacation and is illegal.It is offered to accept as such criterion the labor function fixed by the statutory act of authorized federal executive authority for concrete positions of employees of the medical organizations providing performance of work with sick infectious diseases. The recommendations to heads of the medical organizations concerning the publication of local acts on the organization of vaccinal prevention of flu and adoption of administrative decisions after written refusals of vaccination are provided.

  18. Deciphering the Sunshine Act: Transparency Regulation and Financial Conflicts in Health Care.

    Science.gov (United States)

    Saver, Richard S

    2017-11-01

    The Physician Payments Sunshine Act ("Sunshine Act"), enacted to address financial conflicts in health care, is the first comprehensive federal legislation mandating public reporting of payments between drug companies, device manufacturers, and medicine. This article analyzes the Sunshine Act's uneven record, exploring how the law serves as an intriguing example of the uncertain case for transparency regulation in health care. The Sunshine Act's bumpy rollout demonstrates that commanding transparency through legislation can be arduous because of considerable implementation challenges. Capturing all the relevant information about financial relationships and reporting it with sufficient contextual and comparative data has proven disappointingly difficult. In addition, the law suffers from uncertainty and poor design as to the intended audience. Indeed, there is strong reason to believe that it will not significantly impact decision-making of primary recipients like patients. Yet the Sunshine Act nonetheless retains important and perhaps underappreciated value. From the almost four years of information generated, we have learned that industry-medicine financial ties vary significantly by physician specialty, and somewhat by physician gender. In many medical fields the distribution of top dollar payments tends to be heavily skewed to a few recipients, all of which have important implications for optimal management of financial conflicts and for health policy more generally. Accordingly, the Sunshine Act's greatest potential is not guiding decisions of individual patients or physicians, but its downstream effects. This Article traces how secondary audiences, such as regulators, watchdogs, and counsel are already starting to make productive use of Sunshine Act information. Public reporting has, for example, made more feasible linking industry payment information with Medicare reimbursement data. As a result, policymakers can more closely examine correlations between

  19. 78 FR 4725 - Escrow Requirements Under the Truth in Lending Act (Regulation Z)

    Science.gov (United States)

    2013-01-22

    ... the Truth in Lending Act (TILA), 15 U.S.C. 1601 et seq., based on findings that economic stability... Current Mortgage Origination Market Even with the economic downturn and tightening of credit standards...'' numbered 7, 10, 11, and 12, maintained by the Economic Research Service (ERS) of the United States...

  20. 78 FR 63408 - Petition To Amend Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears...

    Science.gov (United States)

    2013-10-24

    ... Inspection Service 9 CFR Parts 2 and 3 [Docket No. APHIS-2012-0107] Petition To Amend Animal Welfare Act... the comment period for a petition requesting amendments to the Animal Welfare Act regulations and... notice \\1\\ making available for comment a petition requesting amendments to the Animal Welfare Act...

  1. let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis

    Directory of Open Access Journals (Sweden)

    M. Patterson

    2014-11-01

    Full Text Available It is clear that neural differentiation from human pluripotent stem cells generates cells that are developmentally immature. Here, we show that the let-7 plays a functional role in the developmental decision making of human neural progenitors, controlling whether these cells make neurons or glia. Through gain- and loss-of-function studies on both tissue and pluripotent derived cells, our data show that let-7 specifically regulates decision making in this context by regulation of a key chromatin-associated protein, HMGA2. Furthermore, we provide evidence that the let-7/HMGA2 circuit acts on HES5, a NOTCH effector and well-established node that regulates fate decisions in the nervous system. These data link the let-7 circuit to NOTCH signaling and suggest that this interaction serves to regulate human developmental progression.

  2. 76 FR 16818 - Central Valley Project Improvement Act, Standard Criteria for Ag and Urban Water Management Plans

    Science.gov (United States)

    2011-03-25

    ... Valley Project water conservation best management practices (BMPs) that shall develop Criteria for... project contractors using best available cost- effective technology and best management practices.'' The... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Central Valley Project Improvement Act, Standard...

  3. 77 FR 56741 - Federal Acquisition Regulation; NAICS and Size Standards

    Science.gov (United States)

    2012-09-13

    ... available for use in Federal contracting until the Small Business Administration (SBA) publishes... contracting until the Small Business Administration publishes corresponding industry size standards (see 19... DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE...

  4. Toward analytic aids for standard setting in nuclear regulation

    International Nuclear Information System (INIS)

    Brown, R.V.; O'Connor, M.F.; Peterson, C.R.

    1979-05-01

    US NRC promulgates standards for nuclear reprocessing and other facilities to safeguard against the diversion of nuclear material. Two broad tasks have been directed toward establishing performance criteria for standard settings: general-purpose modeling, and analysis specific to a particular performance criterion option. This report emphasizes work on the second task. Purpose is to provide a framework for the evaluation of such options that organizes the necessary components in a way that provides for meaningful assessments with respect to required inputs

  5. Dynamic Spectrum Access: regulations, standards and green radio policy considerations

    CSIR Research Space (South Africa)

    Mfupe, L

    2012-09-01

    Full Text Available of ICT-related emissions globally. The overarching goal is to reach consensus within the global ICT sector on a common methodological framework for the measurement of energy consumption and carbon emissions arising from the production, and operation... of the standards that are of interest in the context of this paper include: (Note all IEEE standards are defined in [39]): ETSI reconfigurable radio systems (RRS) [37]: ETSI considers the feasibility of possible operations of the long- term evolution (LTE...

  6. On the reform of the regulations in the Atomic Energy Act concerning governmental supervision

    International Nuclear Information System (INIS)

    Rebentisch, M.

    1991-01-01

    The deliberations on the amendment to the Atomic Energy Act aim at a harmonization with the Federal Immission Control Act. This holds especially for the area of regulations dealing with the installation. With its function as a licensing law for industrial installations the Federal Immission Control Act has a key position in technology and safety law. The lecture deals especially with the obligation to inform and with the right of the supervising authority to reserve its consent to minor alterations; legal qualification and lawfulness of the reservation of consent; reservation of consent to the start-up after an exchange of fuel elements; requirement of a permit for the decommissioning of installations. (orig./HSCH) [de

  7. Regulations, guidelines, standards, and policies pertaining to decontamination and decommissioning activities: A literature review

    International Nuclear Information System (INIS)

    Cowgill, M.G.

    1993-09-01

    A literature review has been conducted of the existing rules, regulations, and guidelines pertaining to the decontamination and decommissioning of nuclear facilities. Included in the survey are US Government documents, national (industrial) standards, international standards and guidelines, and the regulations issued by various national governments, such as the United Kingdom, Canada, and Germany

  8. 25 CFR 1000.464 - What personal conflicts of interest must the standards of conduct regulate?

    Science.gov (United States)

    2010-04-01

    ... conduct regulate? 1000.464 Section 1000.464 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... interest must the standards of conduct regulate? The personal conflicts of interest standards must: (a... financial interest or an employment relationship; (b) Prohibit such officers, employees, or agents from...

  9. 25 CFR 900.235 - What personal conflicts of interest must the standards of conduct regulate?

    Science.gov (United States)

    2010-04-01

    ... conduct regulate? 900.235 Section 900.235 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... must the standards of conduct regulate? The standards must prohibit an officer, employee, or agent... involving an entity in which such persons have a direct financial interest or an employment relationship. It...

  10. 78 FR 12005 - Regulation of Fuels and Fuel Additives: 2013 Renewable Fuel Standards; Public Hearing

    Science.gov (United States)

    2013-02-21

    ... Regulation of Fuels and Fuel Additives: 2013 Renewable Fuel Standards; Public Hearing AGENCY: Environmental... EPA is announcing a public hearing to be held for the proposed rule ``Regulation of Fuels and Fuel Additives: 2013 Renewable Fuel Standards,'' which was published separately in the Federal Register on...

  11. Evaluation on applicability of the rules, regulations, and industrial codes and standards for SMART development

    International Nuclear Information System (INIS)

    Choi, Suhn; Lee, C C.; Lee, C.K.; Kim, K.K.; Kim, J.P.; Kim, J.H.; Cho, B.H.; Kang, D J.; Bae, G.H.; Chung, M.; Chang, M.H.

    1999-03-01

    In this report, evaluation on applicability of the rules, regulations, and industrial codes and standards for SMART has been made. As the first step, past-to-present status of licensing structures were reviewed. Then, the rules, regulations, and standards applied to YGN 3-6 were listed and reviewed. Finally, evaluation on applicability of such rules and standards for SMART are made in each design fields. During this step technical evaluations on each items of rules, regulations and standards are made and the possible remedies or comments are suggested. The results are summarized in a tabular form and enclosed as Appendix. (Author). 8 refs., 5 tabs., 3 figs

  12. Self-Monitoring of Self-Regulation during Math Homework Behaviour Using Standardized Diaries

    Science.gov (United States)

    Schmitz, Bernhard; Perels, Franziska

    2011-01-01

    This study aims at enhancing math learning and general self-regulation by supporting daily self-regulated learning during math homework. The authors use standardized diaries as a self-monitoring tool to support self-regulatory behaviour. Following the theory of self-monitoring, frequent self-monitoring of self-regulation will lead to an…

  13. 29 CFR 401.17 - Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Act. 401.17 Section 401.17 Labor Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR LABOR-MANAGEMENT STANDARDS MEANING OF TERMS USED IN THIS SUBCHAPTER § 401.17 Act. Act means the Labor-Management Reporting and Disclosure Act...

  14. 28 CFR 45.1 - Cross-reference to ethical standards and financial disclosure regulations.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Cross-reference to ethical standards and...) EMPLOYEE RESPONSIBILITIES § 45.1 Cross-reference to ethical standards and financial disclosure regulations. Employees of the Department of Justice are subject to the executive branch-wide Standards of Ethical Conduct...

  15. 3 CFR 100.1 - Ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Ethical conduct standards and financial disclosure... § 100.1 Ethical conduct standards and financial disclosure regulations. Employees of the Executive Office of the President are subject to the executive branch-wide standards of ethical conduct at 5 CFR...

  16. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2013-02-28

    ...; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense (DOD... collection requirement concerning cost accounting standards administration. A notice was published in the...- 0129, Cost Accounting Standards Administration by any of the following methods: Regulations.gov : http...

  17. 75 FR 37733 - Regulation of Fuels and Fuel Additives: Modifications to Renewable Fuel Standard Program

    Science.gov (United States)

    2010-06-30

    ... Regulation of Fuels and Fuel Additives: Modifications to Renewable Fuel Standard Program AGENCY... direct final rule to amend the Renewable Fuel Standard program requirements on May 10, 2010. Because EPA... Fuel Standard program requirements, published on May 10, 2010. We stated in that direct final rule that...

  18. 48 CFR 852.222-70 - Contract Work Hours and Safety Standards Act-nursing home care contract supplement.

    Science.gov (United States)

    2010-10-01

    ... Safety Standards Act-nursing home care contract supplement. 852.222-70 Section 852.222-70 Federal...—nursing home care contract supplement. As prescribed in 822.305, for nursing home care requirements, insert the following clause: Contract Work Hours and Safety Standards Act—Nursing Home Care Contract...

  19. 77 FR 72746 - Regulation of Fuels and Fuel Additives: Modifications to Renewable Fuel Standard and Diesel...

    Science.gov (United States)

    2012-12-06

    ... Fuels and Fuel Additives: Modifications to Renewable Fuel Standard and Diesel Sulfur Programs AGENCY... Fuel Standard (``RFS'') program under section 211(o) of the Clean Air Act. The direct final rule also... marine diesel fuel produced by transmix processors, and the fuel marker requirements for 500 ppm sulfur...

  20. Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes

    Directory of Open Access Journals (Sweden)

    Jinlong Jian

    2017-09-01

    Full Text Available Multifunctional factor progranulin (PGRN plays an important role in lysosomes, and its mutations and insufficiency are associated with lysosomal storage diseases, including neuronal ceroid lipofuscinosis and Gaucher disease (GD. The first breakthrough in understanding the molecular mechanisms of PGRN as regulator of lysosomal storage diseases came unexpectedly while investigating the role of PGRN in inflammation. Challenged PGRN null mice displayed typical features of GD. In addition, GRN gene variants were identified in GD patients and the serum levels of PGRN were significantly lower in GD patients. PGRN directly binds to and functions as a chaperone of the lysosomal enzyme β-glucocerebrosidase (GCaase, whose mutations cause GD. In addition, its C-terminus containing granulin E domain, termed Pcgin (PGRN C-terminus for GCase Interaction, is required for the association between PGRN and GCase. The concept that PGRN acts as a chaperone of lysosomal enzymes was further supported and extended by a recent article showing that PGRN acts as a chaperone molecule of lysosomal enzyme cathepsin D (CSTD, and the association between PGRN and CSTD is also mediated by PGRN's C-terminal granulin E domain. Collectively, these reports suggest that PGRN may act as a shared chaperone and regulates multiple lysosomal enzymes.

  1. Using variances to comply with resource conservation and recovery act treatment standards

    International Nuclear Information System (INIS)

    Ranek, N.L.

    2002-01-01

    When a waste generated, treated, or disposed of at a site in the United States is classified as hazardous under the Resource Conservation and Recovery Act and is destined for land disposal, the waste manager responsible for that site must select an approach to comply with land disposal restrictions (LDR) treatment standards. This paper focuses on the approach of obtaining a variance from existing, applicable LDR treatment standards. It describes the types of available variances, which include (1) determination of equivalent treatment (DET); (2) treatability variance; and (3) treatment variance for contaminated soil. The process for obtaining each type of variance is also described. Data are presented showing that historically the U.S. Environmental Protection Agency (EPA) processed DET petitions within one year of their date of submission. However, a 1999 EPA policy change added public participation to the DET petition review, which may lengthen processing time in the future. Regarding site-specific treatability variances, data are presented showing an EPA processing time of between 10 and 16 months. Only one generically applicable treatability variance has been granted, which took 30 months to process. No treatment variances for contaminated soil, which were added to the federal LDR program in 1998, are identified as having been granted.

  2. 7 CFR 35.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Act. 35.1 Section 35.1 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices... Definitions § 35.1 Act. Act or Export Grape and Plum Act means “An Act to promote the foreign trade of the...

  3. Regulation of rice root development by a retrotransposon acting as a microRNA sponge.

    Science.gov (United States)

    Cho, Jungnam; Paszkowski, Jerzy

    2017-08-26

    It is well documented that transposable elements (TEs) can regulate the expression of neighbouring genes. However, their ability to act in trans and influence ectopic loci has been reported rarely. We searched in rice transcriptomes for tissue-specific expression of TEs and found them to be regulated developmentally. They often shared sequence homology with co-expressed genes and contained potential microRNA-binding sites, which suggested possible contributions to gene regulation. In fact, we have identified a retrotransposon that is highly transcribed in roots and whose spliced transcript constitutes a target mimic for miR171. miR171 destabilizes mRNAs encoding the root-specific family of SCARECROW-Like transcription factors. We demonstrate that retrotransposon-derived transcripts act as decoys for miR171, triggering its degradation and thus results in the root-specific accumulation of SCARECROW-Like mRNAs. Such transposon-mediated post-transcriptional control of miR171 levels is conserved in diverse rice species.

  4. Benefit using reasonable regulations in USA, how to skill up on professional engineers, apply international code, standard, and regulation

    International Nuclear Information System (INIS)

    Turner, S.L.; Morokuzu, Muneo; Amano, Osamu

    2005-01-01

    The reasonable regulations in USA consist of a graduated approach and a risk informed approach (RIA). RIA rationalizes the regulations on the basis of data of operations etc. PSA (Probabilistic Safety Assessment), a general method of RIA, is explained in detail. The benefits of nuclear power plant using RIA are increase of the rate of operation, visualization of risk, application of design standard and design, cost down of nuclear fuel cycle, waste, production and operation, and safety. RIA is supported by the field data, code, standard, regulation and professional engineers. The effects of introduction of RIA are explained. In order to introduce RIA in Japan, all the parties concerned such as the regulation authorities, the electric power industries, makers, universities, have to understand it and work together. A part of scientific society is stated. (S.Y.)

  5. Identification of trans-acting factors regulating SamDC expression in Oryza sativa

    Energy Technology Data Exchange (ETDEWEB)

    Basu, Supratim, E-mail: supratim_genetics@yahoo.co.in [Department of Crop Soil and Environmental Sciences, University of Arkansas, Fayetteville, AR 72701 (United States); Division of Plant Biology, Bose Institute, Kolkata (India); Roychoudhury, Aryadeep [Post Graduate Department of Biotechnology, St. Xavier' s College (Autonomous), 30, Mother Teresa Sarani, Kolkata - 700016, West Bengal (India); Sengupta, Dibyendu N. [Division of Plant Biology, Bose Institute, Kolkata (India)

    2014-03-07

    Highlights: • Identification of cis elements responsible for SamDC expression by in silico analysis. • qPCR analysis of SamDC expression to abiotic and biotic stress treatments. • Detection of SamDC regulators using identified cis-elements as probe by EMSA. • Southwestern Blot analysis to predict the size of the trans-acting factors. - Abstract: Abiotic stress affects the growth and productivity of crop plants; to cope with the adverse environmental conditions, plants have developed efficient defense machinery comprising of antioxidants like phenolics and flavonoids, and osmolytes like polyamines. SamDC is a key enzyme in the polyamine biosynthesis pathway in plants. In our present communication we have done in silico analysis of the promoter region of SamDC to look for the presence of different cis-regulatory elements contributing to its expression. Based on the presence of different cis-regulatory elements we completed comparative analysis of SamDC gene expression in rice lamina of IR-29 and Nonabokra by qPCR in response to the abiotic stress treatments of salinity, drought, cold and the biotic stress treatments of ABA and light. Additionally, to explore the role of the cis-regulatory elements in regulating the expression of SamDC gene in plants we comparatively analyzed the binding of rice nuclear proteins prepared from IR-29 and Nonabokra undergoing various stress treatments. The intensity of the complex formed was low and inducible in IR-29 in contrast to Nonabokra. Southwestern blot analysis helped in predicting the size of the trans-acting factors binding to these cis-elements. To our knowledge this is the first report on the comprehensive analysis of SamDC gene expression in rice and identification of the trans-acting factors regulating its expression.

  6. Evaluation of the Navy Implementation of DOD Financial Management Regulation, Volume 14, Administrative Control of Funds and Antideficiency Act Violations

    National Research Council Canada - National Science Library

    Lane, F

    1996-01-01

    On August 1, 1995, the Under Secretary of Defense (Comptroller) released for implementation Financial Management Regulation, volume 14, "Administrative Control of Funds and Antideficiency Act Violations," August 1, 1995...

  7. Nanometrology, Standardization and Regulation of Nanomaterials in Brazil: A Proposal for an Analytical-Prospective Model

    Directory of Open Access Journals (Sweden)

    Ana Rusmerg Giménez Ledesma

    2013-05-01

    Full Text Available The main objective of this paper is to propose an analytical-prospective model as a tool to support decision-making processes concerning metrology, standardization and regulation of nanomaterials in Brazil, based on international references and ongoing initiatives in the world. In the context of nanotechnology development in Brazil, the motivation for carrying out this research was to identify potential benefits of metrology, standardization and regulation of nanomaterials production, from the perspective of future adoption of the model by the main stakeholders of development of these areas in Brazil. The main results can be summarized as follows: (i an overview of international studies on metrology, standardization and regulation of nanomaterials, and nanoparticles, in special; (ii the analytical-prospective model; and (iii the survey questionnaire and the roadmapping tool for metrology, standardization and regulation of nanomaterials in Brazil, based on international references and ongoing initiatives in the world.

  8. Addressing the Issue of Microplastics in the Wake of the Microbead-Free Waters Act-A New Standard Can Facilitate Improved Policy.

    Science.gov (United States)

    McDevitt, Jason P; Criddle, Craig S; Morse, Molly; Hale, Robert C; Bott, Charles B; Rochman, Chelsea M

    2017-06-20

    The United States Microbead-Free Waters Act was signed into law in December 2015. It is a bipartisan agreement that will eliminate one preventable source of microplastic pollution in the United States. Still, the bill is criticized for being too limited in scope, and also for discouraging the development of biodegradable alternatives that ultimately are needed to solve the bigger issue of plastics in the environment. Due to a lack of an acknowledged, appropriate standard for environmentally safe microplastics, the bill banned all plastic microbeads in selected cosmetic products. Here, we review the history of the legislation and how it relates to the issue of microplastic pollution in general, and we suggest a framework for a standard (which we call "Ecocyclable") that includes relative requirements related to toxicity, bioaccumulation, and degradation/assimilation into the natural carbon cycle. We suggest that such a standard will facilitate future regulation and legislation to reduce pollution while also encouraging innovation of sustainable technologies.

  9. Knowledge of the Animal Welfare Act and Animal Welfare Regulations Influences Attitudes toward Animal Research

    Science.gov (United States)

    2015-01-01

    Recent public-opinion polls indicate that Americans have shown a decline in support for animal experimentation, and several reports suggest a relationship between people's knowledge of animal welfare regulations and their attitudes toward animal research. Therefore, this study was designed to assess respondent's knowledge of several provisions in the Animal Welfare Act (AWA) and Animal Welfare Regulations (AWR), and determine whether exposure to elements of this legislation would influence an individual's attitudes toward the use of animals in research. A survey was used to assess knowledge of animal research regulations and attitudes toward animal research from a sample of individuals recruited through Amazon's Mechanical Turk crowdsourcing marketplace. Results from study 1 confirmed the hypothesis that respondents had little knowledge of various federal regulations that govern animal research activities. Data from study 2 revealed that exposure to elements of the AWA and AWR influenced participants’ attitudes toward the use of animals in research. These results suggest that providing information to the general public about the AWA and AWR that protect laboratory animals from abuse and neglect may help alleviate concerns about using animals in research settings. PMID:25651094

  10. 76 FR 38153 - California State Nonroad Engine Pollution Control Standards; Commercial Harbor Craft Regulations...

    Science.gov (United States)

    2011-06-29

    ... Standards; Commercial Harbor Craft Regulations; Opportunity for Public Hearing and Comment AGENCY... engines on commercial harbor craft. CARB has requested that EPA issue a new authorization under [email protected] . SUPPLEMENTARY INFORMATION: I. California's Commercial Harbor Craft Regulations In a...

  11. Standard contract terms regulation in the proposal for a common European sales law

    NARCIS (Netherlands)

    Loos, M.B.M.

    2012-01-01

    In this paper, the regulation in standard contract terms in the proposal for a Commono European Sales Law (CESL) is compared with the regulation in the Unfair Terms Directive, the Draft Common Frame of Reference (DCFR) and the Vienna Sales Convention (CISG). The paper starts with an overview of the

  12. 15 CFR 19.3 - Do these regulations adopt the Federal Claims Collection Standards (FCCS)?

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Do these regulations adopt the Federal... of Commerce COMMERCE DEBT COLLECTION General Provisions § 19.3 Do these regulations adopt the Federal Claims Collection Standards (FCCS)? This Part adopts and incorporates all provisions of the FCCS. This...

  13. 36 CFR 1011.3 - Do these regulations adopt the Federal Claims Collections Standards?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Do these regulations adopt... PRESIDIO TRUST DEBT COLLECTION General Provisions § 1011.3 Do these regulations adopt the Federal Claims Collections Standards? This part adopts and incorporates all provisions of the FCCS. This part also...

  14. 31 CFR 5.3 - Do these regulations adopt the Federal Claims Collection Standards (FCCS)?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Do these regulations adopt the... Secretary of the Treasury TREASURY DEBT COLLECTION General Provisions § 5.3 Do these regulations adopt the Federal Claims Collection Standards (FCCS)? This part adopts and incorporates all provisions of the FCCS...

  15. 76 FR 18066 - Regulation of Fuels and Fuel Additives: Changes to Renewable Fuel Standard Program

    Science.gov (United States)

    2011-04-01

    ... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 80 Regulation of Fuels and Fuel Additives: Changes to Renewable Fuel Standard Program CFR Correction In Title 40 of the Code of Federal Regulations, Parts 72 to...-generating foreign producers and importers of renewable fuels for which RINs have been generated by the...

  16. The evolution of the structure and application of U.S. NRC regulations and standards

    International Nuclear Information System (INIS)

    Murley, T.E.; Rosztoczy, Z.R.; McPherson, G.D.

    1991-01-01

    NRC regulations and standards and their implementation have evolved from early adaptations of conventional engineering practices to a mature, cohesive set of regulations that govern NRC regulation of nuclear power plant safety in the United States. From a simple set of rules and design criteria and from the standards of the professional engineering societies, a hierarchy of practices, standards, guides, rules and goals has developed. Resting on a foundation of industrial practices, this hierarchy rises through levels of national standards, regulatory guides and standard review plans, policy statements and NRC regulations. The licensing process is evolving today toward one that permits both site approval and standard design certification before the plant is constructed. At the present time, NRC is reviewing five standard designs for certification for a period of 15 years. NRC focuses its regulation of operating nuclear plants on inspections conducted from five regional offices. Resident inspectors, specialist inspectors, and multi-disciplinary inspection teams examine specific plant situations. The results of all these inspections are used to develop a complete understanding of a plant's physical condition, its operation, maintenance and management. To improve safe operation of nuclear plants in the U.S., a most important program, the Systematic Assessment of Licensee Performance, measures operational performance, using a broad spectrum of functional areas. (orig.)

  17. Patient Protection and Affordable Care Act; exchange and insurance market standards for 2015 and beyond. Final rule.

    Science.gov (United States)

    2014-05-27

    This final rule addresses various requirements applicable to health insurance issuers, Affordable Insurance Exchanges (``Exchanges''), Navigators, non-Navigator assistance personnel, and other entities under the Patient Protection and Affordable Care Act and the Health Care and Education Reconciliation Act of 2010 (collectively referred to as the Affordable Care Act). Specifically, the rule establishes standards related to product discontinuation and renewal, quality reporting, non-discrimination standards, minimum certification standards and responsibilities of qualified health plan (QHP) issuers, the Small Business Health Options Program, and enforcement remedies in Federally-facilitated Exchanges. It also finalizes: A modification of HHS's allocation of reinsurance collections if those collections do not meet our projections; certain changes to allowable administrative expenses in the risk corridors calculation; modifications to the way we calculate the annual limit on cost sharing so that we round this parameter down to the nearest $50 increment; an approach to index the required contribution used to determine eligibility for an exemption from the shared responsibility payment under section 5000A of the Internal Revenue Code; grounds for imposing civil money penalties on persons who provide false or fraudulent information to the Exchange and on persons who improperly use or disclose information; updated standards for the consumer assistance programs; standards related to the opt-out provisions for self-funded, non-Federal governmental plans and related to the individual market provisions under the Health Insurance Portability and Accountability Act of 1996 including excepted benefits; standards regarding how enrollees may request access to non-formulary drugs under exigent circumstances; amendments to Exchange appeals standards and coverage enrollment and termination standards; and time-limited adjustments to the standards relating to the medical loss ratio

  18. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2010-01-20

    ... extension of a previously approved information collection requirement concerning cost accounting standards... include pertinent rules and regulations related to the Cost Accounting Standards along with necessary... impact estimates and descriptions in cost accounting practices and also to provide information on CAS...

  19. 78 FR 13298 - Notice of Retrospective Review of the Americans With Disabilities Act Regulations for Over-the...

    Science.gov (United States)

    2013-02-27

    ... accessible OTRB service. An OTRB is defined as ``a bus characterized by an elevated passenger deck located...] Notice of Retrospective Review of the Americans With Disabilities Act Regulations for Over-the-Road Bus... bus (OTRB) operators. The DOT will review regulations specified in the SUPPLEMENTARY INFORMATION...

  20. 41 CFR 105-735.1 - Cross-references to employee ethical conduct standards, financial disclosure regulations, and...

    Science.gov (United States)

    2010-07-01

    ... employee ethical conduct standards, financial disclosure regulations, and other regulations. 105-735.1... CONDUCT § 105-735.1 Cross-references to employee ethical conduct standards, financial disclosure... executive branch-wide standards of ethical conduct at 5 CFR part 2635, GSA's regulations at 5 CFR part 6701...

  1. 36 CFR 400.1 - Cross-references to employees' ethical conduct standards, financial disclosure regulations and...

    Science.gov (United States)

    2010-07-01

    ...' ethical conduct standards, financial disclosure regulations and other conduct rules. 400.1 Section 400.1... CONDUCT § 400.1 Cross-references to employees' ethical conduct standards, financial disclosure regulations... executive branch-wide standards of ethical conduct and financial disclosure regulations at 5 CFR parts 2634...

  2. 24 CFR 0.1 - Cross-reference to employees ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-04-01

    ... ethical conduct standards and financial disclosure regulations. 0.1 Section 0.1 Housing and Urban... Cross-reference to employees ethical conduct standards and financial disclosure regulations. Employees...-wide standards of ethical conduct at 5 CFR part 2635, the Department's regulation at 5 CFR part 7501...

  3. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.

    Directory of Open Access Journals (Sweden)

    Yuna Kim

    2006-06-01

    Full Text Available The genes encoding members of the wingless-related MMTV integration site (WNT and fibroblast growth factor (FGF families coordinate growth, morphogenesis, and differentiation in many fields of cells during development. In the mouse, Fgf9 and Wnt4 are expressed in gonads of both sexes prior to sex determination. Loss of Fgf9 leads to XY sex reversal, whereas loss of Wnt4 results in partial testis development in XX gonads. However, the relationship between these signals and the male sex-determining gene, Sry, was unknown. We show through gain- and loss-of-function experiments that fibroblast growth factor 9 (FGF9 and WNT4 act as opposing signals to regulate sex determination. In the mouse XY gonad, Sry normally initiates a feed-forward loop between Sox9 and Fgf9, which up-regulates Fgf9 and represses Wnt4 to establish the testis pathway. Surprisingly, loss of Wnt4 in XX gonads is sufficient to up-regulate Fgf9 and Sox9 in the absence of Sry. These data suggest that the fate of the gonad is controlled by antagonism between Fgf9 and Wnt4. The role of the male sex-determining switch--Sry in the case of mammals--is to tip the balance between these underlying patterning signals. In principle, sex determination in other vertebrates may operate through any switch that introduces an imbalance between these two signaling pathways.

  4. 77 FR 73459 - California State Motor Vehicle Pollution Control Standards; Notice of Waiver of Clean Air Act...

    Science.gov (United States)

    2012-12-10

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9759-4] California State Motor Vehicle Pollution Control Standards; Notice of Waiver of Clean Air Act Preemption; California's 2010 Model Year Heavy-Duty Vehicle and... for CARB's own motor vehicle pollution control program based on lack of compelling and extraordinary...

  5. 78 FR 42484 - Small Entity Size Standards Under the Regulatory Flexibility Act

    Science.gov (United States)

    2013-07-16

    ... out the purposes of the Small Business Act. An agency may establish other definitions for ``small... Act (RFA) and request for public comment. SUMMARY: The Board is proposing to define ``small business... them within the definition of a Class III rail carrier. DATES: Comments are due by August 15, 2013. FOR...

  6. 76 FR 70921 - Implementation of the Fair Housing Act's Discriminatory Effects Standard

    Science.gov (United States)

    2011-11-16

    ... Housing Act complaints, recognizes the discriminatory effects theory of liability and requires HUD...) (``A violation of the [Act] may be premised on a theory of disparate impact.''); HUD v. Ross, 1994 WL 326437, at *5 (HUD ALJ July 7, 1994) (``Absent a showing of business necessity, facially neutral policies...

  7. 7 CFR 29.13 - The act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false The act. 29.13 Section 29.13 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.13 The act. The Tobacco Inspection Act, approved August 23, 1935. (7...

  8. 18 CFR 3c.1 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-04-01

    ... employee ethical conduct standards and financial disclosure regulations. 3c.1 Section 3c.1 Conservation of... STANDARDS OF CONDUCT § 3c.1 Cross-reference to employee ethical conduct standards and financial disclosure... branch-wide financial disclosure regulations at 5 CFR part 2634, the Standards of Ethical Conduct for...

  9. 77 FR 43081 - Federal Acquisition Regulation; Information Collection; Buy American Act-Free Trade Agreements...

    Science.gov (United States)

    2012-07-23

    ...; Information Collection; Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate AGENCIES... approved information collection requirement concerning the Buy American Act--Free Trade Agreements--Israeli..., Buy American Act--Free Trade Agreements--Israeli Trade Act Certificate, by any of the following...

  10. Clean Air Act Standards and Guidelines for Energy, Engines, and Combustion

    Science.gov (United States)

    This page contains the stationary sources of air pollution for the energy, engines, and combustion industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  11. Clean Air Act Standards and Guidelines for Chemical Production and Distribution

    Science.gov (United States)

    This page contains the stationary sources of air pollution for the chemical production & distribution industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, click on the links below.

  12. Clean Air Act Guidelines and Standards for Solvent Use and Surface Coating Industry

    Science.gov (United States)

    This page contains the stationary sources of air pollution for the solvent use and surface coating industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  13. Clean Air Act Standards and Guidelines for Agriculture, Food and Forestry

    Science.gov (United States)

    This page contains the stationary sources of air pollution for the agriculture, food, and forestry industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  14. Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes.

    Science.gov (United States)

    Uemura, Akiyoshi; Kusuhara, Sentaro; Wiegand, Stanley J; Yu, Ruth T; Nishikawa, Shin-ichi

    2006-02-01

    In response to hypoxia, hypoxia-inducible factors act as the primary proangiogenic triggers by regulating transcription levels of target genes, including VEGF. However, little is known about the specific factors that control other components of the angiogenic process, particularly formation of matrix scaffolds that promote adhesion and migration of endothelial cells. We show that in the postnatal mouse retina, the orphan nuclear receptor tailless (Tlx) is strongly expressed in the proangiogenic astrocytes, which secrete VEGF and fibronectin. Tlx expression by retinal astrocytes is controlled by oxygen concentration and rapidly downregulated upon contact with blood vessels. In mice null for Tlx, retinal astrocytes maintain VEGF expression; however, the extracellular assembly of fibronectin matrices by astrocytes is severely impaired, leading to defective scaffold formation and a complete failure of normal retinal vascular development. This work identifies Tlx as an essential component of the molecular network involved in the hypoxia-inducible proangiogenic switch in retinal astrocytes.

  15. The Clean Air Act implementation and the coal industry: A regulator's perspective

    International Nuclear Information System (INIS)

    Rolka, D.W.

    1991-01-01

    Utility regulators are responsible for insuring that there is a sufficient supply of electricity to meet consumers needs at a reasonable price. The Pennsylvania Public Utility Commission Act (CAA) compliance strategies are effective at the lowest possible cost. Those potential compliance costs in Pennsylvania may exceed $3 billion by the end of the decade. This does not include worst case estimates of over $750 million per year in added operations and maintenance costs. In the face of these expenses, concerns such as jobs and the health of Pennsylvania's coal industry may carry little weight. The Commission cannot relieve companies of their responsibility for complying. Thus, in order to maintain its market among electric companies, coal will have to be competitive both in offering solutions to the emissions requirements of the CAA and in providing acceptable alternatives for future, new generating plants

  16. Drug evaluation and the permissive principle: continuities and contradictions between standards and practices in antidepressant regulation.

    Science.gov (United States)

    Abraham, John; Davis, Courtney

    2009-08-01

    Pharmaceuticals are not permitted on to the market unless they are granted regulatory approval. The regulatory process is, therefore, crucial in whether or not a drug is widely prescribed. Regulatory agencies have developed standards of performance that pharmaceuticals are supposed to meet before entering the market. Regulation of technologies is often discussed by reference to the precautionary principle. In contrast, this paper develops the concept of the 'permissive principle' as a way of understanding the departure of regulators' practices from standards of drug efficacy to which regulatory agencies themselves subscribe. By taking a case study of antidepressant regulation in the UK and the USA, the mechanisms of permissive regulatory practices are examined. An STS methodology of both spatial (international) and temporal comparisons of regulatory practices with regulatory standards is employed to identify the nature and extent of the permissive regulation. It is found that the permissive principle was adopted by drug regulators in the UK and the USA, but more so by the former than the latter. Evidently, permissive regulation, which favours the commercial interests of the drug manufacturer, but is contrary to the interests of patients, may penetrate to the heart of regulatory science. On the other hand, permissive regulation of specific drugs should not be regarded as an inevitable result of marketing strategies and concomitant networks deployed by powerful pharmaceutical companies, because the extent of permissive regulation may vary according to the intra-institutional normative commitments of regulators to uphold their technical standards against the commercial interests of the manufacturer. Likely sociological factors that can account for such permissive regulatory practices are 'corporate bias', secrecy and excessive regulatory trust in the pharmaceutical industry in the UK, political expediency and ideological capture in the USA, combined in both countries

  17. The Massachusetts Toxics Use Reduction Act: a model for nanomaterials regulation?

    Science.gov (United States)

    Nash, Jennifer

    2012-08-01

    Nanomaterials exemplify a new class of emerging technologies that have significant economic and social value, pose uncertain health and environmental risks, and are entering the marketplace at a rapid pace. Effective regimes for regulating emerging technologies generate information about known or suspected hazards and draw on private sector expertise to guide managers' behavior toward risk reduction, even in the absence of clear evidence of harm. This paper considers the extent to which the federal Toxic Substances Control Act (TSCA) accomplishes those objectives. It offers the approach of the Massachusetts Toxics Use Reduction Act (TURA) as a possible supplement to TSCA, filling gaps in agency knowledge and private sector capacities. TURA is notable for its focus on chemicals use and hazard and its emphasis on strengthening firms' internal management systems. Given the current deadlock in Congressional efforts to modernize federal laws such as TSCA, the role of state laws like TURA merit attention. Absent definitive information about risk, a governance strategy that generates information and focuses management attention on reducing hazards is worth considering.

  18. The Massachusetts Toxics Use Reduction Act: a model for nanomaterials regulation?

    International Nuclear Information System (INIS)

    Nash, Jennifer

    2012-01-01

    Nanomaterials exemplify a new class of emerging technologies that have significant economic and social value, pose uncertain health and environmental risks, and are entering the marketplace at a rapid pace. Effective regimes for regulating emerging technologies generate information about known or suspected hazards and draw on private sector expertise to guide managers’ behavior toward risk reduction, even in the absence of clear evidence of harm. This paper considers the extent to which the federal Toxic Substances Control Act (TSCA) accomplishes those objectives. It offers the approach of the Massachusetts Toxics Use Reduction Act (TURA) as a possible supplement to TSCA, filling gaps in agency knowledge and private sector capacities. TURA is notable for its focus on chemicals use and hazard and its emphasis on strengthening firms’ internal management systems. Given the current deadlock in Congressional efforts to modernize federal laws such as TSCA, the role of state laws like TURA merit attention. Absent definitive information about risk, a governance strategy that generates information and focuses management attention on reducing hazards is worth considering.

  19. Flavonoids act as negative regulators of auxin transport in vivo in arabidopsis

    Science.gov (United States)

    Brown, D. E.; Rashotte, A. M.; Murphy, A. S.; Normanly, J.; Tague, B. W.; Peer, W. A.; Taiz, L.; Muday, G. K.

    2001-01-01

    Polar transport of the plant hormone auxin controls many aspects of plant growth and development. A number of synthetic compounds have been shown to block the process of auxin transport by inhibition of the auxin efflux carrier complex. These synthetic auxin transport inhibitors may act by mimicking endogenous molecules. Flavonoids, a class of secondary plant metabolic compounds, have been suggested to be auxin transport inhibitors based on their in vitro activity. The hypothesis that flavonoids regulate auxin transport in vivo was tested in Arabidopsis by comparing wild-type (WT) and transparent testa (tt4) plants with a mutation in the gene encoding the first enzyme in flavonoid biosynthesis, chalcone synthase. In a comparison between tt4 and WT plants, phenotypic differences were observed, including three times as many secondary inflorescence stems, reduced plant height, decreased stem diameter, and increased secondary root development. Growth of WT Arabidopsis plants on naringenin, a biosynthetic precursor to those flavonoids with auxin transport inhibitor activity in vitro, leads to a reduction in root growth and gravitropism, similar to the effects of synthetic auxin transport inhibitors. Analyses of auxin transport in the inflorescence and hypocotyl of independent tt4 alleles indicate that auxin transport is elevated in plants with a tt4 mutation. In hypocotyls of tt4, this elevated transport is reversed when flavonoids are synthesized by growth of plants on the flavonoid precursor, naringenin. These results are consistent with a role for flavonoids as endogenous regulators of auxin transport.

  20. Radioactive materials packaging standards and regulations: Making sense of it all

    International Nuclear Information System (INIS)

    Pope, R.B.; Rawl, R.R.

    1989-01-01

    Numerous regulations and standards, both national and international, apply to the packaging and transportation of radioactive material. These are legal and technical prerequisites to practically every action that a designer or user of a radioactive material transportation package will perform. The identity and applicability of these requirements and the bodies that formulate them are also not readily understood. This paper addresses the roles that various international bodies play in developing and implementing the various regulations and standards. It uses the US regulatory and standards-making bodies to illustrate how international requirements feed the domestic control of packaging and transport. It explains the scope and interactions between domestic and international regulatory and standards agencies and summarizes the status and major standards activities at the international level. The overview provided by this paper will be valuable to designers and users of radioactive material packages for better understanding and use of both standards and regulations, and for complying with regulatory requirements in the radioactive materials transportation field. 11 refs., 2 figs

  1. Some impacts of the 1990 Clean Air Act and state clean-air regulations on the fertilizer industry

    International Nuclear Information System (INIS)

    Breed, C.E.; Kerns, O.S.

    1992-01-01

    The Clean Air Act amendments of 1990 will intensify national efforts to reduce air pollution. They will have major impacts on governmental agencies and on industrial and commercial facilities throughout the country. As with other industries, it is essential for fertilizer dealers and producers to understand how these changes to the Clean Air Act can significantly change the way they do business. This paper is proffered as an overview of ways in which the 1990 amendments to the Clean Air Act may impact the fertilizer industry. The nonattainment, toxics, and permit provisions of the amended act will be three areas of particular concern to the fertilizer industry. Implementation of the new regulatory requirements of this legislation promises to be a long and onerous process for all concerned. However, it appears that state and local regulations may have a much more profound impact on the fertilizer industry than the new Clean Air Act

  2. Endocannabinoid system acts as a regulator of immune homeostasis in the gut.

    Science.gov (United States)

    Acharya, Nandini; Penukonda, Sasi; Shcheglova, Tatiana; Hagymasi, Adam T; Basu, Sreyashi; Srivastava, Pramod K

    2017-05-09

    Endogenous cannabinoids (endocannabinoids) are small molecules biosynthesized from membrane glycerophospholipid. Anandamide (AEA) is an endogenous intestinal cannabinoid that controls appetite and energy balance by engagement of the enteric nervous system through cannabinoid receptors. Here, we uncover a role for AEA and its receptor, cannabinoid receptor 2 (CB2), in the regulation of immune tolerance in the gut and the pancreas. This work demonstrates a major immunological role for an endocannabinoid. The pungent molecule capsaicin (CP) has a similar effect as AEA; however, CP acts by engagement of the vanilloid receptor TRPV1, causing local production of AEA, which acts through CB2. We show that the engagement of the cannabinoid/vanilloid receptors augments the number and immune suppressive function of the regulatory CX3CR1 hi macrophages (Mϕ), which express the highest levels of such receptors among the gut immune cells. Additionally, TRPV1 -/- or CB2 -/- mice have fewer CX3CR1 hi Mϕ in the gut. Treatment of mice with CP also leads to differentiation of a regulatory subset of CD4 + cells, the Tr1 cells, in an IL-27-dependent manner in vitro and in vivo. In a functional demonstration, tolerance elicited by engagement of TRPV1 can be transferred to naïve nonobese diabetic (NOD) mice [model of type 1 diabetes (T1D)] by transfer of CD4 + T cells. Further, oral administration of AEA to NOD mice provides protection from T1D. Our study unveils a role for the endocannabinoid system in maintaining immune homeostasis in the gut/pancreas and reveals a conversation between the nervous and immune systems using distinct receptors.

  3. 76 FR 48863 - Federal Travel Regulation (FTR); Relocation Allowances-Standard Mileage Rate for Moving Purposes

    Science.gov (United States)

    2011-08-09

    ... Travel Regulation (FTR); Relocation Allowances--Standard Mileage Rate for Moving Purposes AGENCY: Office... agencies will reimburse an employee for using a privately owned vehicle for relocation on a worldwide basis...), Office of Travel, Transportation and Asset Management (MT), General Services Administration at (202) 208...

  4. 75 FR 22805 - Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of...

    Science.gov (United States)

    2010-04-30

    ... GENERAL SERVICES ADMINISTRATION [Proposed GSA Bulletin FTR 10-XXX; Docket 2010-0009; Sequence 1] Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of Transaction... GSA is posting online a proposed FTR bulletin that contains the data dictionary that large Federal...

  5. 78 FR 27913 - Revision of Crane Regulation Standards for Mobile Offshore Drilling Units (MODUs), Offshore...

    Science.gov (United States)

    2013-05-13

    ...)(1) by updating the reference for API nameplate data to reflect its location in the latest edition of.... Civil Justice Reform I. Protection of Children J. Indian Tribal Governments K. Energy Effects L... existing regulations by adopting the most recent editions of API Spec. 2C and RP 2D standards. By updating...

  6. 77 FR 1319 - Regulation of Fuels and Fuel Additives: 2012 Renewable Fuel Standards

    Science.gov (United States)

    2012-01-09

    ... fuels such as ethanol and biodiesel. Potentially regulated categories include: NAICS \\1\\ Examples of... they are produced as well as the cost associated with transporting these fuels to the U.S. Of the... II.E, we believe that the 1.0 billion gallon standard can indeed be met. Since biodiesel has an...

  7. Multi-objective regulations on transportation fuels: Comparing renewable fuel mandates and emission standards

    International Nuclear Information System (INIS)

    Rajagopal, D.; Plevin, R.; Hochman, G.; Zilberman, D.

    2015-01-01

    We compare two types of fuel market regulations — a renewable fuel mandate and a fuel emission standard — that could be employed to simultaneously achieve multiple outcomes such as reduction in fuel prices, fuel imports and greenhouse gas (GHG) emissions. We compare these two types of regulations in a global context taking into account heterogeneity in carbon content of both fossil fuels and renewable fuels. We find that although neither the ethanol mandate nor the emission standard is certain to reduce emissions relative to a business-as-usual baseline, at any given level of biofuel consumption in the policy region, a mandate, relative to an emission standard, results in higher GHG emissions, smaller expenditure on fuel imports, lower price of ethanol-blended gasoline and higher domestic fuel market surplus. This result holds over a wide range of values of model parameters. We also discuss the implications of this result to a regulation such as the US Renewable Fuel Standard given recent developments within the US such as increase in shale and tight oil production and large increase in average vehicle fuel economy of the automotive fleet. - Highlights: • Biofuel mandates and fuel GHG emission standards are analyzed from a multiple criteria perspective • An emission-standard always results in lower global emissions while requiring less biofuel relative to a biofuel mandate • An emission-standard results in higher fuel price in the home region relative to a biofuel mandate • Emission standards lead to more shuffling of both fossil fuels and biofuels between home and abroad • The relative impact of the policies on fuel imports depends on the relative cost-effectiveness of domestic & imported biofuel • Recent developments oil production and fuel economy increase the net benefits of an LCFS approach relative to RFS

  8. 77 FR 17219 - Patient Protection and Affordable Care Act; Standards Related to Reinsurance, Risk Corridors and...

    Science.gov (United States)

    2012-03-23

    ... professional trade associations and societies, medical and health care professional entities, health insurance... American Academy of Actuaries. In subpart C of the proposed rule, we proposed to codify in regulation...

  9. Implementation of the Preventive Radiation Protection Act; here: Regulation governing ambient radioactivity monitoring subject to the Preventive Radiation Protection Act. Pt. 1. Measuring programme for specified normal operation monitoring (routine measuring programme). BMU circular letter dated 28.07.94 -RS II 6 - 15 603/3

    International Nuclear Information System (INIS)

    1994-01-01

    The regulation addresses the competent Federal and Land authorities responsible for implementation of the Preventive Radiation Protection Act, and the competent highest Land authorities. The regulation defines the scope of obligatory measurement of ambient radioactivity during normal operation of installations and determines the measuring techniques to be applied for this purpose. The programme determines compulsory instructions to be observed in the performance of the routine measuring programme by the competent Federal and Land authorities and thus ensures nationwide application of standard procedures

  10. Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity.

    Science.gov (United States)

    Miah, Mohammad Alam; Byeon, Se Eun; Ahmed, Md Selim; Yoon, Cheol-Hee; Ha, Sang-Jun; Bae, Yong-Soo

    2013-09-01

    Early growth response gene 2 (Egr2), which encodes a zinc finger transcription factor, is rapidly and transiently induced in various cell types independently of de novo protein synthesis. Although a role for Egr2 is well established in T-cell development, Egr2 expression and its biological function in dendritic cells (DCs) have not yet been described. Here, we demonstrate Egr2 expression during DC development, and its role in DC-mediated immune responses. Egr2 is expressed in the later stage of DC development from BM precursor cells. Even at steady state, Egr2 is highly expressed in mouse splenic DCs. Egr2-knockdown (Egr2-KD) DCs showed increased levels of major histocompatability complex (MHC) class I and II and co-stimulatory molecules, and enhanced antigen uptake and migratory capacities. Furthermore, Egr2-KD abolished SOCS1 expression and signal transducer and activator of transcription 5 (STAT5) activation during DC development, probably resulting in the enhancement of IL-12 expression and Th1 immunogenicity of a DC vaccine. DC-mediated cytotoxic T lymphocyte (CTL) activation and antitumor immunity were significantly enhanced by Egr2-KD, and impaired by Egr2 overexpression in antigen-pulsed DC vaccines. These data suggest that Egr2 acts as an intrinsic negative regulator of DC immunogenicity and can be an attractive molecular target for DC vaccine development. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.

    Science.gov (United States)

    Ichimura, Atsuhiko; Hirasawa, Akira; Hara, Takafumi; Tsujimoto, Gozoh

    2009-09-01

    Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120). These fatty acid receptors are proposed to play critical roles in a variety of types of physiological homeostasis. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain, but not long-chain, FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. FFAR1 is expressed mainly in pancreatic beta-cells and mediates insulin secretion, whereas GPR120 is expressed abundantly in the intestine and promotes the secretion of glucagon-like peptide-1 (GLP-1). FFAR3 is expressed in enteroendocrine cells and regulates host energy balance through effects that are dependent upon the gut microbiota. In this review, we summarize the identification, structure, and pharmacology of these receptors and present an essential overview of the current understanding of their physiological roles.

  12. Deficiencies of regulation of euthanasia in legal acts of foreign countries

    Directory of Open Access Journals (Sweden)

    Polaks R.

    2014-01-01

    Full Text Available Today in most countries the practising of euthanasia is not permissible and as in any case of a criminal offence, which endangers the life of a person, criminal liability applies here. However, the analysis of legal norms in foreign criminal codes reveals several deficiencies, ranging from – the absence of legal regulation which leads to a paradoxical situation, when ignoring the motive and aim of the offence, euthanasia is qualified according to the article of the criminal code which provides for liability for murder with no mitigating circumstances, but assisted suicide liability does not apply at all, – to including special legal norms pertaining to this problematic issue, in the structure of criminal codes, in the disposition of which there is an absence of several mandatory constituent elements of these particular criminal offences, thus unduly extending the provision of these norms in practice also in the cases not related to “easy death”. The deficiencies of legal acts are observed also in those few countries which allow a definite form of euthanasia and its practising by means of special laws. And most importantly, foreign legislators ignore such forms of terminating the lives of incurably ill persons as active and passive non-voluntary euthanasia, which depending on the nature of the offence requires an appropriate legal framework, which so far has not been observed.

  13. Analysis and design of a standardized control module for switching regulators

    Science.gov (United States)

    Lee, F. C.; Mahmoud, M. F.; Yu, Y.; Kolecki, J. C.

    1982-07-01

    Three basic switching regulators: buck, boost, and buck/boost, employing a multiloop standardized control module (SCM) were characterized by a common small signal block diagram. Employing the unified model, regulator performances such as stability, audiosusceptibility, output impedance, and step load transient are analyzed and key performance indexes are expressed in simple analytical forms. More importantly, the performance characteristics of all three regulators are shown to enjoy common properties due to the unique SCM control scheme which nullifies the positive zero and provides adaptive compensation to the moving poles of the boost and buck/boost converters. This allows a simple unified design procedure to be devised for selecting the key SCM control parameters for an arbitrarily given power stage configuration and parameter values, such that all regulator performance specifications can be met and optimized concurrently in a single design attempt.

  14. 77 FR 33635 - Amendment to the Bank Secrecy Act Regulations-Requirement That Clerks of Court Report Certain...

    Science.gov (United States)

    2012-06-07

    ... business rule reflects that the definition of currency used therein is slightly different from the... Amendment to the Bank Secrecy Act Regulations--Requirement That Clerks of Court Report Certain Currency...: FinCEN is amending the rules relating to the reporting of certain currency transactions consistent...

  15. Proposals for the Radioactive Substances (Basic Safety Standards) (England and Wales) Regulations 2000 and the Radioactive Substances (Basic Safety Standards) (England and Wales) Direction 2000. Consultative document

    International Nuclear Information System (INIS)

    2000-01-01

    This document contains proposals for changes to the Radioactive Substances Act 1993 (RSA 93) and proposals for a Direction to be given to the Environment Agency in order to implement aspects of the European Directive 96/29/Euratom concerned with the control of radioactive waste. The Directive lays down basic safety standards for the protection of the health of workers and the general public against the dangers arising from ionising radiation. With the Government pledged to making government more accessible and responsive, an important feature of this approach is effective consultation with all interested organisations. This leads to more realistic and robust proposals, which is particularly important when dealing with proposed legislation. In March this year, the Government published a consultation paper 'The Radioactive Substances Act 1993: Implementing the Revised Basic Safety Standards Directive Euratom 96/29.' This sought comments on the basic principles for change - including the setting of levels of radioactivity below which radioactive material should be considered outside the framework of regulatory control. This document forms the second stage of the consultation process with the aim of gathering views on the proposed legal instruments to implement the Directive. This document: explains the background to the proposed regulations (paragraphs 8-13); summarises the results of the consultation on principles (paragraphs 14-24); describes the proposed changes (paragraphs 25-36); includes draft Regulations (paragraphs 27-29); includes a draft Direction to the Environment Agency (paragraphs 30-36); describes the next steps (paragraphs 37-39); includes a draft Regulatory Impact Assessment (paragraphs 40-41). In general, the devolved administrations in Scotland, Wales and Northern Ireland have assumed responsibility for environmental issues and hence management of radioactive waste policies and legislation affecting their respective countries. However, this

  16. 78 FR 6621 - Ability To Repay Standards Under the Truth in Lending Act (Regulation Z)

    Science.gov (United States)

    2013-01-30

    ... increase the cost of credit for those who do, thereby impacting the availability of credit for these at... mortgage delinquencies and foreclosure rates increased dramatically, caused in part by the gradual...

  17. 76 FR 18831 - Updating Regulations Issued Under the Fair Labor Standards Act

    Science.gov (United States)

    2011-04-05

    ... Changes The FLSA requires covered employers to pay their nonexempt employees a Federal minimum wage and...) in a work week. The FLSA also contains a number of exemptions from the minimum wage and overtime pay... clarify the minimum wage and overtime pay requirements. A 1974 amendment to section 13(b)(10) of the FLSA...

  18. Institutionalizing environmental protection through self-regulation: the case of environmental standards adoption in Lithuania.

    Science.gov (United States)

    Bileisis, Mantas; Misiune, Ieva

    2017-04-01

    The impacts of human activity in the environment have a global dimension, but there are no effective global governance instruments to enforce environmental standards. At the same time, many national governments lack incentives to pursue strict environmental policies. In this context, self-regulation is seen as an alternative venue to address environmental challenges. This work aims to identify factors that influence companies to engage in environmental self-regulation? For this aim in March 2015 a survey of 482 companies was conducted. The target group were companies operating in Lithuania that hold ISO14001 certificates - one of the most prolific instruments for self-regulation. The questionnaire was designed to test assumptions developed in new institutionalist literature which claim that common practices can emerge through isomorphism.- The results showed that the main motive for environmental self-regulation is the desire to improve company image, rather than protecting the environment per se. Another important finding was that the main source of pressure to adopt self-regulation was based less on the perceived demands but the customers. Rather the driver for the adoption was a feeling of a need no to fall behind industry leaders. Thus, normative isomorphism is the main mechanism through which environmental self-regulation proliferates. We claim for a rapid proliferation of environmental self-regulation perceived industry leaders need to be identified and they need to be persuaded that environmental standards are key for the development of the industry. However, this also raises questions of sustainability. Few industries have long standing leaders, and through successful investment and technological development new actors can arise and this may risk stalling or even reversing self-regulation.

  19. 78 FR 35575 - Black Lung Benefits Act: Standards for Chest Radiographs

    Science.gov (United States)

    2013-06-13

    ... toll-free number). Only comments of ten or fewer pages, including a Fax cover sheet and attachments, if... have different fee structures for film and digital radiographs. Instead, standard medical coding...

  20. Proteomic Analysis Reveals the Leaf Color Regulation Mechanism in Chimera Hosta "Gold Standard" Leaves.

    Science.gov (United States)

    Yu, Juanjuan; Zhang, Jinzheng; Zhao, Qi; Liu, Yuelu; Chen, Sixue; Guo, Hongliang; Shi, Lei; Dai, Shaojun

    2016-03-08

    Leaf color change of variegated leaves from chimera species is regulated by fine-tuned molecular mechanisms. Hosta "Gold Standard" is a typical chimera Hosta species with golden-green variegated leaves, which is an ideal material to investigate the molecular mechanisms of leaf variegation. In this study, the margin and center regions of young and mature leaves from Hosta "Gold Standard", as well as the leaves from plants after excess nitrogen fertilization were studied using physiological and comparative proteomic approaches. We identified 31 differentially expressed proteins in various regions and development stages of variegated leaves. Some of them may be related to the leaf color regulation in Hosta "Gold Standard". For example, cytosolic glutamine synthetase (GS1), heat shock protein 70 (Hsp70), and chloroplastic elongation factor G (cpEF-G) were involved in pigment-related nitrogen synthesis as well as protein synthesis and processing. By integrating the proteomics data with physiological results, we revealed the metabolic patterns of nitrogen metabolism, photosynthesis, energy supply, as well as chloroplast protein synthesis, import and processing in various leaf regions at different development stages. Additionally, chloroplast-localized proteoforms involved in nitrogen metabolism, photosynthesis and protein processing implied that post-translational modifications were crucial for leaf color regulation. These results provide new clues toward understanding the mechanisms of leaf color regulation in variegated leaves.

  1. Nutrient supply to organic agriculture as governed by EU regulations and standards in six European countries

    DEFF Research Database (Denmark)

    Løes, Anne Kristin; Bünemann, E.K.; Cooper, J.

    2017-01-01

    -farm P sources include conventional animal manure, composted or anaerobically digested organic residues, rock phosphate, and some animal residues such as meat and bone meal. The recent proposed revision of EU regulations for organic production (2014) puts less emphasis on closing nutrient cycles...... as means are taken to ensure the quality and safety of these inputs. Awareness of the need to close nutrient cycles may contribute to adapting regulations and private standards to support recycling of nutrients from society to organic agriculture. A better definition of the term “natural substance...

  2. 78 FR 6762 - Food and Drug Administration Food Safety Modernization Act: Proposed Rules To Establish Standards...

    Science.gov (United States)

    2013-01-31

    .... For example, applying the concept of Hazard Analysis and Critical Control Point (HACCP) that was pioneered by industry in the late 1960s, FDA established HACCP-based regulations for seafood (21 CFR part... Service instituted HACCP-based rules for meat and poultry (9 CFR part 417) (61 FR 38806, July 25, 1996...

  3. 29 CFR 1990.151 - Model standard pursuant to section 6(b) of the Act.

    Science.gov (United States)

    2010-07-01

    ...) The employer shall assure that in the regulated area, food or beverages are not present or consumed... ___; (B) Engineering plans and other studies contemplated or used to determine the controls for each... circumstances). Whenever food or beverages are consumed in the workplace, the employer shall provide lunchroom...

  4. 13 CFR 105.101 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... ethical conduct standards and financial disclosure regulations. 105.101 Section 105.101 Business Credit... RESPONSIBILITIES Standards of Conduct § 105.101 Cross-reference to employee ethical conduct standards and financial... to the Standards of Ethical Conduct for Employees of the Executive Branch at 5 CFR part 2635 and the...

  5. 34 CFR 73.1 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Cross-reference to employee ethical conduct standards... of Education STANDARDS OF CONDUCT § 73.1 Cross-reference to employee ethical conduct standards and... branch-wide Standards of Ethical Conduct at 5 CFR part 2635 and to the Department of Education regulation...

  6. From outcomes to acts : a non-standard axiomatization of the expected utility principle

    NARCIS (Netherlands)

    Peterson, M.B.

    2004-01-01

    This paper presents an axiomatization of the principle of maximizing expected utility that does not rely on the independence axiom or sure-thing principle. Perhaps more importantly the new axiomatization is based on an ex ante approach, instead of the standard ex post approach. An ex post approach

  7. Recovery Act: Water Heater ZigBee Open Standard Wireless Controller

    Energy Technology Data Exchange (ETDEWEB)

    Butler, William P. [Emerson Electric Co., St. Louis, MO (United States); Buescher, Tom [Emerson Electric Co., St. Louis, MO (United States)

    2014-04-30

    The objective of Emerson's Water Heater ZigBee Open Standard Wireless Controller is to support the DOE's AARA priority for Clean, Secure Energy by designing a water heater control that levels out residential and small business peak electricity demand through thermal energy storage in the water heater tank.

  8. 7 CFR 62.400 - OMB control number assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) LIVESTOCK, MEAT, AND OTHER AGRICULTURAL COMMODITIES (QUALITY SYSTEMS VERIFICATION...

  9. Environmental impact assessment modern dressed? To the amendment of the EIA act and other acts and regulations; Umweltvertraeglichkeitspruefung im modernen Gewand? Zur Aenderung des UVP-Gesetzes und zahlreicher weiterer Gesetze und Verordnungen

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2017-03-15

    On 22 December 2016, the Federal Ministry for the Environment (BMUB) presented the ''Draft Act for the Modernization of the Act on the Environmental Impact Assessment'' within the framework of the association consultation, as well as the ''Draft first Ordinance Amending the Ordinance on the Approval Procedure - 9. BImSchV''. The EIA Modernization Act as well as the Atomic Act Procedure Regulation and the Federal Mining Act should be revised by terms of an omnibus act. The association consultation was held on 18 January 2017.

  10. Regulations, Codes, and Standards (RCS) Template for California Hydrogen Dispensing Stations

    Energy Technology Data Exchange (ETDEWEB)

    Rivkin, C.; Blake, C.; Burgess, R.; Buttner, W.; Post, M.

    2012-11-01

    This report explains the Regulations, Codes, and Standards (RCS) requirements for hydrogen dispensing stations in the State of California. The reports shows the basic components of a hydrogen dispensing station in a simple schematic drawing; the permits and approvals that would typically be required for the construction and operation of a hydrogen dispensing station; and a basic permit that might be employed by an Authority Having Jurisdiction (AHJ).

  11. HARMONIZATION OF NATIONAL REGULATION AND INTERNATIONAL FINANCIAL REPORTING STANDARDS – PARTICULAR CASE OF NONCURRENT ASSETS

    Directory of Open Access Journals (Sweden)

    Coste Andreea Ioana

    2013-07-01

    Full Text Available In the scientific literature, accounting harmonization is a top topic because it helps to increase the comparability of financial statements. Also in Romania in the last 10 years becames a topic that is very often debated. The harmonization is trying to reduce differences of financial reporting statements between countries or, in the other words, it is trying to bring to a common denominator of existing rules when appear conflicts of comparability between them. The purpose of this paper is to measure the harmonisation between national and international regulation for a significant element of financial position statement, such as noncurrent assets. This paper provides an empirical research of information that must be presented by entities which apply national accounting standards or international ones when financial statements are prepared, trying to measure the harmonization between the two referential. Thus, in trying to determine the harmonisation, we use the Jaccard coefficient in order to provide an overview of the degree of harmonization of accounting practice. When measuring the degree of comparability of Romanian accounting regulations with International Accounting Standards we analyzed noncurrent assets and impairment of assets using the Jaccard coefficient for accounting treatments and we calculated an average of similarities between the two regulations. Further, the results suggest that there is an average level of harmonization for the accounting treatment of noncurrent assets and for determining the impairment of the assets, the methods are the same. The study contributes to the development of accounting literature about the harmonisation between national regulation and international standards regarding the noncurrent assets and impairment of the assets, which together with the other elements define the activity of the business. In addition, the study provides an analysis of how the regulations treats noncurrent assets, during the

  12. Canada's Clean Air Act

    International Nuclear Information System (INIS)

    2006-01-01

    This paper provided an outline of Canada's Clean Air Act and examined some of the regulatory changes that will occur as a result of its implementation. The Act is being introduced to strengthen the legislative basis for taking action on reducing air pollution and GHGs, and will allow the government to regulate both indoor and outdoor air pollutants and GHGs. The Act will require the Ministers of the Environment and Health to establish national air quality objectives, as well as to monitor and report on their attainment. The Canadian Environmental Protection Act will be amended to enable the government to regulate the blending of fuels and their components. The Motor Vehicle Fuel Consumption Standards Act will also be amended to enhance the government's authority to regulate vehicle fuel efficiency. The Energy Efficiency Act will also be expanded to allow the government to set energy efficiency standards and labelling requirements for a wider range of consumer and commercial products. The Act will commit to short, medium and long-term industrial air pollution targets. Regulations will be proposed for emissions from industry; on-road and off-road vehicles and engines; and consumer and commercial products. It was concluded that the Government of Canada will continue to consult with provinces, territories, industries and Canadians to set and reach targets for the reduction of both indoor and outdoor air pollutants and GHG emissions. 6 figs

  13. 29 CFR 2703.1 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Cross-reference to employee ethical conduct standards and...-reference to employee ethical conduct standards and financial disclosure regulations. Members and employees... of Ethical Conduct at 5 CFR part 2635; the Commission's regulations at 5 CFR part 8401, which...

  14. 12 CFR 264.101 - Cross-reference to employees' ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Cross-reference to employees' ethical conduct... § 264.101 Cross-reference to employees' ethical conduct standards and financial disclosure regulations... branch-wide standards of ethical conduct at 5 CFR part 2635 and the Board's regulation at 5 CFR part 6801...

  15. 29 CFR 0.735-1 - Cross-references to employee ethical conduct standards, financial disclosure regulations and...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Cross-references to employee ethical conduct standards, financial disclosure regulations and other ethics regulations. 0.735-1 Section 0.735-1 Labor Office of the Secretary of Labor ETHICS AND CONDUCT OF DEPARTMENT OF LABOR EMPLOYEES Standards of Conduct for Current...

  16. The management of electronic documents generated from compilation and revision processes of nuclear and radiation safety regulations and standards

    International Nuclear Information System (INIS)

    Wang Wenhai; Fan Yun; Shang Zhaorong

    2010-01-01

    As the Secretary Group of Regulations and Standards Review Committee on nuclear and radiation safe needs to deal with a large number of electronic documents in course of the regulation and standard review meetings, the article gives a systematical method including electronic document file naming and management as well as procedures of file transfer, storage and usage. (authors)

  17. 25 CFR 542.4 - How do these regulations affect minimum internal control standards established in a Tribal-State...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false How do these regulations affect minimum internal control... COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.4 How do these regulations affect minimum internal control standards established in a Tribal-State compact? (a) If there is a...

  18. Regulating web content: the nexus of legislation and performance standards in the United Kingdom and Norway.

    Science.gov (United States)

    Giannoumis, G Anthony

    2014-01-01

    Despite different historical traditions, previous research demonstrates a convergence between regulatory approaches in the United Kingdom and Norway. To understand this convergence, this article examines how different policy traditions influence the legal obligations of performance standards regulating web content for use by persons with disabilities. While convergence has led to similar policy approaches, I argue that national policy traditions have an impact on how governments establish legal obligations for standards compliance. The analysis reveals that national policy traditions influenced antidiscrimination legislation and the capacity and authority of regulatory agencies, which impacted the diverging legal obligations of standards in the United Kingdom and Norway. The analysis further suggests that policy actors mediate the reciprocal influence between national policy traditions and regulatory convergence mechanisms. Copyright © 2014 John Wiley & Sons, Ltd.

  19. 75 FR 12377 - Native American Graves Protection and Repatriation Act Regulations-Disposition of Culturally...

    Science.gov (United States)

    2010-03-15

    ... support of a particular religious point of view or excessive entanglement with religion in the context of... Religious Freedom Act. Our Response: The proposed change revised the regulatory definition of cultural... Freedom Act. Section 10.2(e)(2) Definition of Culturally Unidentifiable Section 10.2(e)(2) defines the...

  20. 78 FR 57808 - Rules and Regulations Under the Wool Products Labeling Act of 1939

    Science.gov (United States)

    2013-09-20

    ... noted a Cashmere and Camel Hair Manufacturers Institute study finding that, between 2004 and 2009, false... wool.\\26\\ The Joint Comment, however, reported the lack of consensus in the trade regarding ``how the S... with the Wool Act, to establish a complete defense to false advertising claims under the Lanham Act as...

  1. 78 FR 8963 - Update of Existing Privacy Act-NASA Regulations

    Science.gov (United States)

    2013-02-07

    ... FR 60622] inadvertently omits the responsibility of NASA's Freedom of Information Act (FOIA) Office..., this correction adds responsibility of the FOIA Office. This corrections also corrects the title to Sec... appropriate system manager, or, if unknown, to the Center Privacy Manager or Freedom of Information Act (FOIA...

  2. 76 FR 63817 - Disclosure of Information; Privacy Act Regulations; Notice and Amendments

    Science.gov (United States)

    2011-10-14

    ..., paper, reports of examination, work papers, and correspondence relating to such reports, to the.... Regulatory Flexibility Act The Regulatory Flexibility Act, 5 U.S.C. 601, et seq., (RFA) applies only to rules... and comment requirements of the APA, the requirement to prepare a final regulatory flexibility...

  3. 14 CFR 374.3 - Compliance with the Consumer Credit Protection Act and regulations.

    Science.gov (United States)

    2010-01-01

    ... requirements of the Consumer Credit Protection Act, 15 U.S.C. 1601-1693r. Any violation of the following... PROTECTION ACT WITH RESPECT TO AIR CARRIERS AND FOREIGN AIR CARRIERS § 374.3 Compliance with the Consumer... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Compliance with the Consumer Credit...

  4. 78 FR 54250 - Federal Acquisition Regulation; Information Collection; American Recovery and Reinvestment Act...

    Science.gov (United States)

    2013-09-03

    ... Recovery Act; d. A narrative description of the employment impact of the Recovery Act funded work; and e... subcontracts awarded to a subcontractor that in the previous tax year had gross income under $300,000, the... data was a sufficient baseline for estimating the number of respondents per year (2,247) that would...

  5. 25 CFR 309.1 - How do the regulations in this part carry out the Indian Arts and Crafts Act of 1990?

    Science.gov (United States)

    2010-04-01

    ... Arts and Crafts Act of 1990? 309.1 Section 309.1 Indians INDIAN ARTS AND CRAFTS BOARD, DEPARTMENT OF THE INTERIOR PROTECTION OF INDIAN ARTS AND CRAFTS PRODUCTS § 309.1 How do the regulations in this part carry out the Indian Arts and Crafts Act of 1990? These regulations define the nature and Indian origin...

  6. Caught in the act? Prevalence, predictors, and consequences of physician detection of unannounced standardized patients.

    Science.gov (United States)

    Franz, Carol E; Epstein, Ron; Miller, Katherine N; Brown, Arthur; Song, Jun; Feldman, Mitchell; Franks, Peter; Kelly-Reif, Steven; Kravitz, Richard L

    2006-12-01

    Objective. To examine the prevalence, predictors, and consequences of physician detection of unannounced standardized patients (SPs) in a study of the impact of direct-to-consumer advertising on treatment for depression. Data Sources. Eighteen trained SPs were randomly assigned to conduct 298 unannounced audio-recorded visits with 152 primary care physicians in three U.S. cities between May 2003 and May 2004. Study Design. Randomized controlled trial using SPs. SPs portrayed six roles, created by crossing two clinical conditions (major depression or adjustment disorder) with three medication request scripts (brand-specific request, general request for an antidepressant, or no request). Data Collection. Within 2 weeks following the visit, physicians completed a form asking whether they "suspected" conducting an office visit with an SP during the past 2 weeks; 296 (99 percent) detection forms were returned. Physicians provided contextual data, a Clinician Background Questionnaire. SPs filled in a Standardized Patient Reporting Form for each visit and returned all written prescriptions and medication samples to the laboratory. Principal Findings. Depending on the definition, detection rates ranged from 5 percent (unambiguous detection) to 23.6 percent (any degree of suspicion) of SP visits. In 12.8 percent of encounters, physicians accurately detected the SP before or during the visit but they only rarely believed their suspicions affected their clinical behavior. In random effects logistic regression analyses controlling for role, actor, physician, and practice factors, suspected visits occurred less frequently in HMO settings than in solo practice settings (pactors portrayed patient roles conveying mood disorders at low levels of detection. There was some evidence for differential treatment of detected standardized patients by physicians with regard to referrals but not antidepressant prescribing or follow-up recommendations. Systematic assessment of detection is

  7. Co-operative development of nuclear safety regulations, guides and standards based on NUSS

    International Nuclear Information System (INIS)

    Pachner, J.; Boyd, F.C.; Yaremy, E.M.

    1985-01-01

    A major need of developing Member States building nuclear power plants (NPPs) of foreign origin is to acquire a capability to regulate such nuclear plants independently. Among other things, this requires the development of national nuclear safety regulations, guides and standards to govern the development and use of nuclear technology. Recognizing the importance and complexity of this task, it seems appropriate that the NPP-exporting Member States share their experience and assist the NPP-importing Member States in the development of their national regulations and guides. In 1983, the Atomic Energy Control Board and Atomic Energy of Canada Ltd. conducted a study of a possible joint programme involving Canada, an NPP-importing Member State and the IAEA for the development of the national nuclear safety regulations and guides based on NUSS documents. During the study, a work plan with manpower estimates for the development of design regulations, safety guides and a guide for regulatory evaluation of design was prepared as an investigatory exercise. The work plan suggests that a successful NUSS implementation in developing Member States will require availability of significant resources at the start of the programme. The study showed that such a joint programme could provide an effective mechanism for transfer of nuclear safety know-how to the developing Member States through NUSS implementation. (author)

  8. Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.

    Science.gov (United States)

    Koziel, Lydia; Wuelling, Manuela; Schneider, Sabine; Vortkamp, Andrea

    2005-12-01

    During endochondral ossification, the secreted growth factor Indian hedgehog (Ihh) regulates several differentiation steps. It interacts with a second secreted factor, parathyroid hormone-related protein (PTHrP), to regulate the onset of hypertrophic differentiation, and it regulates chondrocyte proliferation and ossification of the perichondrium independently of PTHrP. To investigate how the Ihh signal is translated in the different target tissues, we analyzed the role of the zinc-finger transcription factor Gli3, which acts downstream of hedgehog signals in other organs. Loss of Gli3 in Ihh mutants restores chondrocyte proliferation and delays the accelerated onset of hypertrophic differentiation observed in Ihh-/- mutants. Furthermore the expression of the Ihh target genes patched (Ptch) and PTHrP is reactivated in Ihh-/-;Gli3-/- mutants. Gli3 seems thus to act as a strong repressor of Ihh signals in regulating chondrocyte differentiation. In addition, loss of Gli3 in mice that overexpress Ihh in chondrocytes accelerates the onset of hypertrophic differentiation by reducing the domain and possibly the level of PTHrP expression. Careful analysis of chondrocyte differentiation in Gli3-/- mutants revealed that Gli3 negatively regulates the differentiation of distal, low proliferating chondrocytes into columnar, high proliferating cells. Our results suggest a model in which the Ihh/Gli3 system regulates two distinct steps of chondrocyte differentiation: (1) the switch from distal into columnar chondrocytes is repressed by Gli3 in a PTHrP-independent mechanism; (2) the transition from proliferating into hypertrophic chondrocytes is regulated by Gli3-dependent expression of PTHrP. Furthermore, by regulating distal chondrocyte differentiation, Gli3 seems to position the domain of PTHrP expression.

  9. GP supervisors' experience in supporting self-regulated learning: a balancing act

    NARCIS (Netherlands)

    Sagasser, M.H.; Kramer, A.W.M.; Weel, C. van; Vleuten, C.P.M. van der

    2015-01-01

    Self-regulated learning is essential for professional development and lifelong learning. As self-regulated learning has many inaccuracies, the need to support self-regulated learning has been recommended. Supervisors can provide such support. In a prior study trainees reported on the variation in

  10. Regulations under the Radiation Protection and Control Act, 1982, No. 27 of 1984

    International Nuclear Information System (INIS)

    1984-01-01

    These regulations provide for the control and administration of transporting, packaging and storing radioactive materials in South Australia. Such operations must be carried out in accordance with the Code of Practice for the Safe Transport of Radioactive Substances, the present Regulations and the IAEA Regulations for the Safe Transport of Radioactive Materials (1973 Edition), slightly amended for purposes of national application. (NEA) [fr

  11. GP Supervisors' Experience in Supporting Self-Regulated Learning: A Balancing Act

    Science.gov (United States)

    Sagasser, Margaretha H.; Kramer, Anneke W. M.; van Weel, Chris; van der Vleuten, Cees P. M.

    2015-01-01

    Self-regulated learning is essential for professional development and lifelong learning. As self-regulated learning has many inaccuracies, the need to support self-regulated learning has been recommended. Supervisors can provide such support. In a prior study trainees reported on the variation in received supervisor support. This study aims at…

  12. The regulation of hazardous air pollutants under the Clean Air Act Amendments of 1990: Effects on the Portland cement industry

    International Nuclear Information System (INIS)

    Mikols, E.H.; Gill, A.S.; Dougherty, A.

    1996-01-01

    Title III of the 1990 Clean Air Act Amendments (CAAA) addresses the control of hazardous air pollutants (HAPs) from major sources of air pollution in the US. In the CAAA, Congress defined 189 compounds as hazardous air pollutants in need of additional control by the Environmental Protection Agency (EPA). Congress directed EPA to identify the major source categories which emit HAPs and to prepare regulations that would reduce and control future HAP emissions. This paper outlines the activities undertaken by EPA to regulate HAP emissions from Portland cement plants and the program developed by the Portland cement manufacturing industry to cope with Title III

  13. Acting Globally: Potential Carbon Emissions Mitigation Impacts from an International Standards and Labelling Program

    Energy Technology Data Exchange (ETDEWEB)

    McNeil, Michael A; Letschert, Virginie E.; de la Rue du Can, Stephane; Egan, Christine

    2009-05-29

    This paper presents an analysis of the potential impacts of an international initiative designed to support and promote the development and implementation of appliances standards and labelling programs throughout the world. As part of previous research efforts, LBNL developed the Bottom Up Energy Analysis System (BUENAS), an analysis framework that estimates impact potentials of energy efficiency policies on a global scale. In this paper, we apply this framework to an initiative that would result in the successful implementation of programs focused on high priority regions and product types, thus evaluating the potential impacts of such an initiative in terms of electricity savings and carbon mitigation in 2030. In order to model the likely parameters of such a program, we limit impacts to a five year period starting in 2009, but assume that the first 5 years of a program will result in implementation of 'best practice' minimum efficiency performance standards by 2014. The 'high priority' regions considered are: Brazil, China, the European Union,India, Mexico and the United States. The products considered are: refrigerators, air conditioners, lighting (both fluorescent and incandescent), standby power (for consumer electronics) and televisions in the residential sector, and air conditioning and lighting in commercial buildings. In 2020, these regions and enduses account for about 37percent of global residential electricity and 29percent of electricity in commercial buildings. We find that 850Mt of CO2 could be saved in buildings by 2030 compared to the baseline forecast.

  14. A novel radiation responsive cis-acting element regulates gene induction and mediates tissue injury

    International Nuclear Information System (INIS)

    Hallahan, Dennis E.; Virudachalam, Subbulakshmi; Kuchibahtla, Jaya

    1997-01-01

    containing binding domains for the transcription factors AP-1 and Ets. This DNA sequence (TGCCTCAGTTTCCC) is similar to antioxidant responsive element. X-ray- mediated transcriptional activation of the 5' regulatory region of ICAM-1 required the antioxidant responsive element (ARE). Electrophoretic mobility shift analysis of nuclear proteins from irradiated endothelial cells incubated with the ARE binding domain (5'-GCTGCTGCCTCAGTTTCCC-3') showed increased protein-DNA complexes at 60 and 120 minutes after irradiation. Conclusions: 1) ICAM induction in irradiated tissue occurs in the microvascular endothelium. 2) ICAM expression contributes to the pathogenesis of radiation-mediated tissue injury and the ICAM knockout serves as a model for the study of the pathogenesis of tissue injury. 3) ICAM expression is regulated by a novel radiation-inducible cis-acting element that has homology to previously identified antioxidant responsive elements

  15. Worldwide Regulations of Standard Values of Pesticides for Human Health Risk Control: A Review

    Science.gov (United States)

    Jennings, Aaron

    2017-01-01

    The impact of pesticide residues on human health is a worldwide problem, as human exposure to pesticides can occur through ingestion, inhalation, and dermal contact. Regulatory jurisdictions have promulgated the standard values for pesticides in residential soil, air, drinking water, and agricultural commodity for years. Until now, more than 19,400 pesticide soil regulatory guidance values (RGVs) and 5400 pesticide drinking water maximum concentration levels (MCLs) have been regulated by 54 and 102 nations, respectively. Over 90 nations have provided pesticide agricultural commodity maximum residue limits (MRLs) for at least one of the 12 most commonly consumed agricultural foods. A total of 22 pesticides have been regulated with more than 100 soil RGVs, and 25 pesticides have more than 100 drinking water MCLs. This research indicates that those RGVs and MCLs for an individual pesticide could vary over seven (DDT drinking water MCLs), eight (Lindane soil RGVs), or even nine (Dieldrin soil RGVs) orders of magnitude. Human health risk uncertainty bounds and the implied total exposure mass burden model were applied to analyze the most commonly regulated and used pesticides for human health risk control. For the top 27 commonly regulated pesticides in soil, there are at least 300 RGVs (8% of the total) that are above all of the computed upper bounds for human health risk uncertainty. For the top 29 most-commonly regulated pesticides in drinking water, at least 172 drinking water MCLs (5% of the total) exceed the computed upper bounds for human health risk uncertainty; while for the 14 most widely used pesticides, there are at least 310 computed implied dose limits (28.0% of the total) that are above the acceptable daily intake values. The results show that some worldwide standard values were not derived conservatively enough to avoid human health risk by the pesticides, and that some values were not computed comprehensively by considering all major human exposure

  16. Worldwide Regulations of Standard Values of Pesticides for Human Health Risk Control: A Review.

    Science.gov (United States)

    Li, Zijian; Jennings, Aaron

    2017-07-22

    Abstract : The impact of pesticide residues on human health is a worldwide problem, as human exposure to pesticides can occur through ingestion, inhalation, and dermal contact. Regulatory jurisdictions have promulgated the standard values for pesticides in residential soil, air, drinking water, and agricultural commodity for years. Until now, more than 19,400 pesticide soil regulatory guidance values (RGVs) and 5400 pesticide drinking water maximum concentration levels (MCLs) have been regulated by 54 and 102 nations, respectively. Over 90 nations have provided pesticide agricultural commodity maximum residue limits (MRLs) for at least one of the 12 most commonly consumed agricultural foods. A total of 22 pesticides have been regulated with more than 100 soil RGVs, and 25 pesticides have more than 100 drinking water MCLs. This research indicates that those RGVs and MCLs for an individual pesticide could vary over seven (DDT drinking water MCLs), eight (Lindane soil RGVs), or even nine (Dieldrin soil RGVs) orders of magnitude. Human health risk uncertainty bounds and the implied total exposure mass burden model were applied to analyze the most commonly regulated and used pesticides for human health risk control. For the top 27 commonly regulated pesticides in soil, there are at least 300 RGVs (8% of the total) that are above all of the computed upper bounds for human health risk uncertainty. For the top 29 most-commonly regulated pesticides in drinking water, at least 172 drinking water MCLs (5% of the total) exceed the computed upper bounds for human health risk uncertainty; while for the 14 most widely used pesticides, there are at least 310 computed implied dose limits (28.0% of the total) that are above the acceptable daily intake values. The results show that some worldwide standard values were not derived conservatively enough to avoid human health risk by the pesticides, and that some values were not computed comprehensively by considering all major human

  17. Problems of standardizing and technical regulation in the electric power industry

    Science.gov (United States)

    Grabchak, E. P.

    2016-12-01

    A mandatory condition to ensure normal operation of a power system and efficiency in the sector is standardization and legal regulation of technological activities of electric power engineering entities and consumers. Compared to the times of USSR, the present-time technical guidance documents are not mandatory to follow in most cases, being of an advisory nature due to the lack of new ones. During the last five years, the industry has been showing a deterioration of the situation in terms of ensuring reliability and engineering controllability as a result of the dominant impact of short-term market stimuli and the differences in basic technological policies. In absence of clear requirements regarding the engineering aspects of such activities, production operation does not contribute to the preserving of technical integrity of the Russian power system, which leads to the loss of performance capability and controllability and causes disturbances in the power supply to consumers. The result of this problem is a high rate of accident incidence. The dynamics of accidents by the type of equipment is given, indicating a persisting trend of growth in the number of accidents, which are of a systematic nature. Several problematic aspects of engineering activities of electric power engineering entities, requiring standardization and legal regulation are pointed out: in the domestic power system, a large number of power electrotechnical and generating equipment operate along with systems of regulation, which do not comply with the principles and technical rules representing a framework where the Energy System of Russia is built and functioning

  18. Drinking water regulations under the Safe Drinking Water Act. Fact sheet

    International Nuclear Information System (INIS)

    1990-12-01

    The fact sheet describes the requirements covered under the 1986 amendments to the Safe Drinking Water Act. Levels of various contaminants (including radio nuclides) are explained. Also discussed are the Surface Water Treatment Rule and the Total Coliforms Rule

  19. Arianespace Launch Service Operator Policy for Space Safety (Regulations and Standards for Safety)

    Science.gov (United States)

    Jourdainne, Laurent

    2013-09-01

    Since December 10, 2010, the French Space Act has entered into force. This French Law, referenced as LOS N°2008-518 ("Loi relative aux Opérations Spatiales"), is compliant with international rules. This French Space Act (LOS) is now applicable for any French private company whose business is dealing with rocket launch or in orbit satellites operations. Under CNES leadership, Arianespace contributed to the consolidation of technical regulation applicable to launch service operators.Now for each launch operation, the operator Arianespace has to apply for an authorization to proceed to the French ministry in charge of space activities. In the files issued for this purpose, the operator is able to justify a high level of warranties in the management of risks through robust processes in relation with the qualification maintenance, the configuration management, the treatment of technical facts and relevant conclusions and risks reduction implementation when needed.Thanks to the historic success of Ariane launch systems through its more than 30 years of exploitation experience (54 successes in a row for latest Ariane 5 launches), Arianespace as well as European public and industrial partners developed key experiences and knowledge as well as competences in space security and safety. Soyuz-ST and Vega launch systems are now in operation from Guiana Space Center with identical and proved risks management processes. Already existing processes have been slightly adapted to cope with the new roles and responsibilities of each actor contributing to the launch preparation and additional requirements like potential collision avoidance with inhabited space objects.Up to now, more than 12 Ariane 5 launches and 4 Soyuz-ST launches have been authorized under the French Space Act regulations. Ariane 5 and Soyuz- ST generic demonstration of conformity have been issued, including exhaustive danger and impact studies for each launch system.This article will detail how Arianespace

  20. Analysis on effects of energy efficiency regulations & standards for industrial boilers in China

    Science.gov (United States)

    Liu, Ren; Chen, Lili; Zhao, Yuejin; Liu, Meng

    2017-11-01

    The industrial boilers in China are featured by large quantity, wide distribution, high energy consumption and heavy environmental pollution, which are key problems faced by energy conservation and environmental protection in China. Meanwhile, industrial boilers are important equipment for national economy and people’s daily life, and energy conservation gets through all segments from type selection, purchase, installation and acceptance to fuel management, operation, maintenance and service. China began to implement such national mandatory standards and regulations for industrial boiler as GB24500-2009 The Minimum Allowable Values of Energy Efficiency and Energy Efficiency Grades of Industrial Boilers and TSG G002-2010 Supervision Regulation on Energy-Saving Technology for Boilers since 2009, which obviously promote the development of energy conservation of industrial boilers, but there are also some problems with the rapid development of technologies for energy conservation of industrial boilers. In this paper, the implementation of energy efficiency standards for industrial boilers in China and the significance are analyzed based on survey data, and some suggestions are proposed for the energy efficiency standards for industrial boilers. Support by Project 2015424050 of Special Fund for quality control Research in the Public Interest

  1. 46 CFR 508.101 - Cross-referrence to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Cross-referrence to employee ethical conduct standards... GENERAL AND ADMINISTRATIVE PROVISIONS EMPLOYEE ETHICAL CONDUCT STANDARDS AND FINANCIAL DISCLOSURE REGULATIONS § 508.101 Cross-referrence to employee ethical conduct standards and financial disclosure...

  2. 29 CFR 1600.101 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Cross-reference to employee ethical conduct standards and... to employee ethical conduct standards and financial disclosure regulations. Employees of the Equal Employment Opportunity Commission (EEOC) are subject to the executive branch-wide Standards of Ethical...

  3. SURROGACY POLICY IN INDIA AND NEED OF ACTS TO REGULATE COMMERCIAL SURROGACY

    OpenAIRE

    Chaturvedi; Garg; Abha; Vidya; Praveen

    2014-01-01

    Surrogacy is an arrangement by which a woman, called as surrogate, carries and delivers the offspring of the commissioning parents and it has been recognized in India under the ART treatment. For commercial surrogacy, there is no any uniform law in India or there is no law that binds or regulates this industry. In this paper, we have focused our attention on the present existing laws or guidelines regulating surrogacy with emphasis on need for stringent laws to regulate co...

  4. International regulations in capital standards in insurance companies and banking system of Serbia

    Directory of Open Access Journals (Sweden)

    Milić Dragana

    2014-01-01

    Full Text Available The emergence and expansion of the recent financial crisis has renewed the question of regulation and supervision of the financial system. Therefore, the question of managing financial risks is becoming increasingly popular and gaining more and more importance. Regulators have in recent years introduced capital standards based on specific sensitivity to risk. Based on defined issues, the starting point is the general hypothesis that the capital adequacy is a key base for measuring the resistance of the banking and insurance sector to market shocks. This paper will present the analytical, synthetic and general scientific methods. The comparative method is used in this paper to highlight the similarities and differences between Solvency II and Basel III and their operational efficiency.

  5. The implications of RCRA [Resource Conservation and Recovery Act] regulation for the disposal of transuranic and high-level waste

    International Nuclear Information System (INIS)

    Sigmon, C.F.; Sharples, F.E.; Smith, E.D.

    1988-01-01

    In May of 1987 the Department of Energy (DOE) published a rule interpreting the definition of ''byproduct'' under the Atomic Energy Act. This byproduct rule clarified the role of the Resource Conservation and Recovery Act (RCRA) in the regulation of DOE's radioactive waste management activities. According to the rule, only the radioactive portion of DOE's mixed radioactive and hazardous waste (mixed waste), including mixed transuranic (TRU) and high-level waste (HLW), is exempt from RCRA under the byproduct exemption. The portion of a waste that is hazardous as defined by RCRA is subject to full regulation under RCRA. Because the radioactive and hazardous portions of m any, if not most, DOE wastes are likely to be inseparable, the rule in effect makes most mixed wastes subject to dual regulation. The potential application of RCRA to facilities such as the Waste Isolation Pilot Plant (WIPP) and the HLW repository creates unique challenges for both the DOE and regulatory authorities. Strategies must be developed to assure compliance with RCRA without either causing excessive administrative burdens or abandoning the goal of minimizing radiation exposure. This paper will explore some of the potential regulatory options for and recent trends in the regulation of TRU and HLW under RCRA

  6. 20 CFR 416.1071 - Good cause for not following the Act, our regulations, or other written guidelines.

    Science.gov (United States)

    2010-04-01

    ..., we will not find that the State agency has substantially failed to meet our standards. We will... regulations, or other written guidelines. 416.1071 Section 416.1071 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Determinations of Disability...

  7. Act No. 25 of 31 January 1983 amending Act No. 1103 of 4 August 1965 and Decree No. 680 of 6 March 1968 on regulations governing the activities of technicians in medical radiology

    International Nuclear Information System (INIS)

    1983-01-01

    This Act amends Act No. 1103 of 4 August 1965 and Decree No. 680 of 6 March 1968 of the President of the Republic regulating the activities of auxiliary personnel engaged in medical radiology. It establishes new conditions for training and qualifications of such technicians in respect of radiodiagnosis, radiotherapy and nuclear medicine. (NEA) [fr

  8. Market effects of environmental regulation: coal, railroads, and the 1990 Clean Air Act

    Energy Technology Data Exchange (ETDEWEB)

    Busse, M.R.; Keohane, N.O. [University of California Berkeley, Berkeley, CA (United States)

    2007-01-01

    Many environmental regulations encourage the use of 'clean' inputs. When the suppliers of such an input have market power, environmental regulation will affect not only the quantity of the input used but also its price. We investigate the effect of the Title IV emissions trading program for sulfur dioxide on the market for low-sulfur coal. We find that the two railroads transporting coal were able to price discriminate on the basis of environmental regulation and geographic location. Delivered prices rose for plants in the trading program relative to other plants, and by more at plants near a low-sulfur coal source.

  9. 76 FR 68690 - Rules and Regulations Under the Textile Fiber Products Identification Act

    Science.gov (United States)

    2011-11-07

    ... Products Identification Act; add or clarify definitions of terms set forth in the Rules; and modify its..., ``Textiles--Man-made fibres--Generic Names'' in Section 303.7.\\1\\ Later in 1998, the Commission amended the... updated version of ISO 2076: 1999(E), ``Textiles--Man-made fibres--Generic Names,'' referenced in Section...

  10. 75 FR 46859 - Lacey Act Implementation Plan; Definitions for Exempt and Regulated Articles

    Science.gov (United States)

    2010-08-04

    ... amended in 1981, is the United States' oldest wildlife protection statute. The Act combats trafficking in... cultivated for human or animal consumption, and (b) Is a species or hybrid that is cultivated on a commercial... cultivated for human or animal consumption; and (b) Is a species or hybrid that is cultivated on a commercial...

  11. 77 FR 4498 - Rules and Regulations Under the Wool Products Labeling Act of 1939

    Science.gov (United States)

    2012-01-30

    ... achieve their intended purpose without unduly burdening commerce. As part of this systematic review, the Commission requests public comment on the overall costs, benefits, necessity, and regulatory and economic..., and on the costs and benefits of certain provisions of the Wool Products Labeling Act of 1939. DATES...

  12. ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing

    NARCIS (Netherlands)

    Royo, Hélène; Prosser, Haydn; Ruzankina, Yaroslava; Mahadevaiah, Shantha K.; Cloutier, Jeffrey M.; Baumann, Marek; Fukuda, Tomoyuki; Höög, Christer; Tóth, Attila; de Rooij, Dirk G.; Bradley, Allan; Brown, Eric J.; Turner, James M. A.

    2013-01-01

    In mammals, homologs that fail to synapse during meiosis are transcriptionally inactivated. This process, meiotic silencing, drives inactivation of the heterologous XY bivalent in male germ cells (meiotic sex chromosome inactivation [MSCI]) and is thought to act as a meiotic surveillance mechanism.

  13. 78 FR 36693 - Rules and Regulations Under the Fur Products Labeling Act

    Science.gov (United States)

    2013-06-19

    ... marketing or sale of the products would violate the Act or Rules.\\27\\ \\27\\ NRF at 5. As discussed in the... products as private label products; unless the retailers knew or should have known that the marketing or... Skills Needed To Comply As explained earlier in this document, the proposed amendments would clarify and...

  14. 20 CFR 626.4 - Table of contents for the Job Training Partnership Act regulations.

    Science.gov (United States)

    2010-04-01

    .... 628.210State Job Training Coordinating Council. 628.215State Human Resource Investment Council... and for general program management. Subpart G [Reserved] Subpart H—Job Training Partnership Act... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Table of contents for the Job Training...

  15. 75 FR 18403 - Rules of Procedure; Regulations Implementing the Government in the Sunshine Act; Implementation...

    Science.gov (United States)

    2010-04-12

    ... to Justice Act in Proceedings Before the Occupational Safety and Health Review Commission; Correction AGENCY: Occupational Safety and Health Review Commission. ACTION: Final rule; correction. [[Page 18404... OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION 29 CFR Parts 2200, 2203, and 2204 Rules of...

  16. 77 FR 57199 - 2012 Real Estate Settlement Procedures Act (Regulation X) Mortgage Servicing Proposal

    Science.gov (United States)

    2012-09-17

    ... servicers under a variety of business models. In some cases, creditors service mortgage loans that they... business model, servicers act primarily as payment collectors and processors, and provide minimal customer... (2011) (Thompson), available at http://digital.law.washington.edu/dspace-law/bitstream/handle/1773.1...

  17. 77 FR 76861 - Removal of Job Training Partnership Act Implementing Regulations

    Science.gov (United States)

    2012-12-31

    ..., 633, 634, 636, 637, and 638 RIN 1205-AB68 Removal of Job Training Partnership Act Implementing...=FR . SUPPLEMENTARY INFORMATION: I. Direct Final Rule Procedure Since removal of the Job Training... barriers to employment for participation in the labor force by providing job training and other services...

  18. PHITS code improvements by Regulatory Standard and Research Department Secretariat of Nuclear Regulation Authority

    International Nuclear Information System (INIS)

    Goko, Shinji

    2017-01-01

    As for the safety analysis to be carried out when a nuclear power company applies for installation permission of facility or equipment, business license, design approval etc., the Regulatory Standard and Research Department Secretariat of Nuclear Regulation Authority continuously conducts safety research for the introduction of various technologies and their improvement in order to evaluate the adequacy of this safety analysis. In the field of the shielding analysis of nuclear fuel transportation materials, this group improved the code to make PHITS applicable to this field, and has been promoting the improvement as a tool used for regulations since FY2013. This paper introduced the history and progress of this safety research. PHITS 2.88, which is the latest version as of November 2016, was equipped with the automatic generation function of variance reduction parameters [T-WWG] etc., and developed as the tool equipped with many effective functions in practical application to nuclear power regulations. In addition, this group conducted the verification analysis against nuclear fuel packages, which showed a good agreement with the analysis by MCNP, which is extensively used worldwide and abundant in actual results. It also shows a relatively good agreement with the measured values, when considering differences in analysis and measurement. (A.O.)

  19. Gap study on technical standards and quality assurance between ITER and Korean regulation

    International Nuclear Information System (INIS)

    Kang, Myoung-suk; Lee, Sangil; Lee, Hyoen Gon; Heo, Gyunyoung

    2016-01-01

    Highlights: • This paper is to secure knowledge and expand domestic specialists for license and regulation of future fusion facilities including K-DEMO. - Abstract: Currently, Korea Domestic Agency (KODA) for the International Thermonuclear Experimental Reactor (ITER) project or the ITER Korea has been conducting follow-up surveys and development researches for the core technologies of its non-procurement items. This eventually aims to secure implicit as well as explicit knowledge and expand domestic specialists for future fusion facilities including K-DEMO. As a part of the project, the comparative analysis and gap study of technical standards and Quality Assurance (QA) system between ITER and Korean nuclear facilities are being performed. The goal of this study is to present a roadmap re-systematizing current safety-related standards for the fission-based facilities into fusion-based facilities in Republic of Korea. The research is considering two different tracks. First one is to secure the state-of-the-art of the fusion technical standards continually updated. For its investigation, we organized the Korean fusion safety advisory group that consists of experts from institutes, industries, and universities. The latest information of technical standards have been gathered and updated from each area of expert in periodic manner. The information is classified into Product Breakdown Structure (PBS) including safety classification, major safety issues, analysis computer codes, etc. This task will be re-organized this year such that the technical standards for procurement as well as non-procurement items can be accumulated in systematic and sustainable manner. Second one, called “Gap Study,” is to compare the requirements for domestic nuclear facilities and the results from the first track on the basis of experts’ opinion from the national and private sectors and to recommend the approaches to overcome technical and administrative barriers. The result is

  20. Gap study on technical standards and quality assurance between ITER and Korean regulation

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Myoung-suk [Kyung Hee University, Yongin-si 446-701, Gyeonggi-do (Korea, Republic of); Lee, Sangil; Lee, Hyoen Gon [National Fusion Research Institute, Daejeon-si 305-333 (Korea, Republic of); Heo, Gyunyoung, E-mail: gheo@khu.ac.kr [Kyung Hee University, Yongin-si 446-701, Gyeonggi-do (Korea, Republic of)

    2016-11-01

    Highlights: • This paper is to secure knowledge and expand domestic specialists for license and regulation of future fusion facilities including K-DEMO. - Abstract: Currently, Korea Domestic Agency (KODA) for the International Thermonuclear Experimental Reactor (ITER) project or the ITER Korea has been conducting follow-up surveys and development researches for the core technologies of its non-procurement items. This eventually aims to secure implicit as well as explicit knowledge and expand domestic specialists for future fusion facilities including K-DEMO. As a part of the project, the comparative analysis and gap study of technical standards and Quality Assurance (QA) system between ITER and Korean nuclear facilities are being performed. The goal of this study is to present a roadmap re-systematizing current safety-related standards for the fission-based facilities into fusion-based facilities in Republic of Korea. The research is considering two different tracks. First one is to secure the state-of-the-art of the fusion technical standards continually updated. For its investigation, we organized the Korean fusion safety advisory group that consists of experts from institutes, industries, and universities. The latest information of technical standards have been gathered and updated from each area of expert in periodic manner. The information is classified into Product Breakdown Structure (PBS) including safety classification, major safety issues, analysis computer codes, etc. This task will be re-organized this year such that the technical standards for procurement as well as non-procurement items can be accumulated in systematic and sustainable manner. Second one, called “Gap Study,” is to compare the requirements for domestic nuclear facilities and the results from the first track on the basis of experts’ opinion from the national and private sectors and to recommend the approaches to overcome technical and administrative barriers. The result is

  1. Review and comparison of quality standards, guidelines and regulations for laboratories

    Directory of Open Access Journals (Sweden)

    Tjeerd A.M. Datema

    2011-12-01

    Full Text Available Background: The variety and number of laboratory quality standards, guidelines and regulations (hereafter: quality documents makes it difficult to choose the most suitable one for establishing and maintaining a laboratory quality management system. Objectives: There is a need to compare the characteristics, suitability and applicability of quality documents in view of the increasing efforts to introduce quality management in laboratories, especially in clinical diagnostic laboratories in low income and middle income countries. This may provide valuable insights for policy makers developing national laboratory policies, and for laboratory managers and quality officers in choosing the most appropriate quality document for upgrading their laboratories. Method: We reviewed the history of quality document development and then selected a subset based on their current use. We analysed these documents following a framework for comparison of quality documents that was adapted from the Clinical Laboratory Standards Institute guideline GP26 Quality management system model for clinical laboratory services. Results: Differences were identified between national and international, and non-clinical and clinical quality documents. The most salient findings were the absence of provisions on occurrence management and customer service in almost all non-clinical quality documents, a low number of safety requirements aimed at protecting laboratory personnel in international quality documents and no requirements regarding ethical behaviour in almost all quality documents. Conclusion: Each laboratory needs to investigate whether national regulatory standards are present. These are preferred as they most closely suit the needs of laboratories in the country. A laboratory should always use both a standard and a guideline: a standard sums up the requirements to a quality management system, a guideline describes how quality management can be integrated in the laboratory

  2. Regulating the advertising of genetic tests in Europe: a balancing act.

    Science.gov (United States)

    Kalokairinou, Louiza; Borry, Pascal; Howard, Heidi Carmen

    2017-10-01

    Direct-to-consumer (DTC) genetic tests (GT) have provoked criticism over their potential adverse impact on public health. The European Parliament called for a ban on DTC advertising of GT during the debate for the adoption of a European Regulation on in vitro diagnostic medical devices. This proposal, however, was not ultimately retained in the final text. Instead, the regulation includes an article prohibiting misleading claims for this kind of advertising. These two different approaches raise questions about the optimal degree of regulation. Herein, we provide an overview of the ways GT have been advertised and related ethical issues. Subsequently, the laws regulating the advertising of GT at the European Union and national level are examined. Finally, recent regulatory developments are discussed. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  3. Electronic Commerce: a battle on regulation, standards transportation media and business integration

    Directory of Open Access Journals (Sweden)

    Kim Andersen

    1998-11-01

    Full Text Available The drive towards the electronic commerce organisation is both a troublesome and a strifted path for government, enterprises and consumers worldwide. In this article we analyse the evolution of electronic commerce in Denmark during the period 1995-1998 from four perspectives: regulation, standards, transportation media and business integration. The Danish government is stimulating the use of electronic commerce using direct and indirect policy initiatives on central, governmental regulation and establishment of greens enabling self-regulation. Also, the governments own, organisational management is in Denmark seen as a mean to exalt electronic commerce. Onwards, the fist on proprietary standards and the UN/EDIFACT is an ongoing source of delaying, stimulating or reventing electronic commerce depending on the business sector and the size of market actor addressed. In Denmark, the direct access and value added network supporters have so far been the dominating mean to transport the electronic documents in the business transaction. The Internet and XML technology is at the turn of the century challenging the way of doing business within this field. Some view this as the big blue to speed the diffusion of electronic commerce; others are worried that the incentive to investment and pull the partners in the value chain to use EDI might be lost. Finally, our study conclude that the debate on business integration issues is ambiguous and characterised by substantial uncertainty on for example the role of intermediates, direct sale, hyper-shift in business partners and the pull/push of global enterprises at the local markets.

  4. Reforming the Regulation of Therapeutic Products in Canada: The Protecting of Canadians from Unsafe Drugs Act (Vanessa’s Law

    Directory of Open Access Journals (Sweden)

    Katherine Fierlbeck

    2016-11-01

    Full Text Available Enacted November 2014, Vanessa’s Law amends the Food and Drugs Act to give Health Canada greater powers to compel the disclosure of information, recall drugs and devices, impose fines and injunctions, and collect post-market safety information. The Act amends seriously outdated legislation that had been in place since 1954. While the explicit goals of the Act are to improve patient safety and provide transparency, it also establishes a regulatory framework that facilitates investment in the burgeoning field of biotechnology. While regulatory reform was already on the public agenda, public awareness of litigation against large pharmaceutical firms combined with the championing of the legislation by Conservative MP Terence Young, whose daughter Vanessa died from an adverse drug reaction, pushed the legislation through to implementation. Many key aspects of the Act depend upon the precise nature of supporting regulations that are still to be implemented. Despite the new powers conferred by the legislation on the Minister of Health, there is some concern that these discretionary powers may not be exercised, and that Health Canada may not have sufficient resources to take advantage of these new powers. Given experience to date since enactment, the new legislation, designed to provide greater transparency vis-à-vis therapeutic products, may actually have a chilling effect on independent scrutiny.

  5. Who regulates the disposal of low-level radioactive waste under the Low-Level Radioactive Waste Policy Act

    International Nuclear Information System (INIS)

    Mostaghel, D.M.

    1988-01-01

    The present existence of immense quantities of low-level nuclear waste, a federal law providing for state or regional control of such waste disposal, and a number of state disposal laws challenged on a variety of constitutional grounds underscore what currently may be the most serious problem in nuclear waste disposal: who is to regulate the disposal of low-level nuclear wastes. This problem's origin may be traced to crucial omissions in the Atomic Energy Act of 1946 and its 1954 amendments (AEA) that concern radioactive waste disposal. Although the AEA states that nuclear materials and facilities are affected with the public interest and should be regulated to provide for the public health and safety, the statute fails to prescribe specific guidelines for any nuclear waste disposal. The Low-Level Radioactive Waste Policy Act of 1980 (LLRWPA) grants states some control over radioactive waste disposal, an area from which they were previously excluded by the doctrine of federal preemption. This Comment discusses the question of who regulates low-level radioactive waste disposal facilities by examining the following: the constitutional doctrines safeguarding federal government authority; area of state authority; grants of specific authority delegations under the LLRWPA and its amendment; and finally, potential problems that may arise depending on whether ultimate regulatory authority is deemed to rest with single states, regional compacts, or the federal government

  6. Arabidopsis MADS-Box Transcription Factor AGL21 Acts as Environmental Surveillance of Seed Germination by Regulating ABI5 Expression.

    Science.gov (United States)

    Yu, Lin-Hui; Wu, Jie; Zhang, Zi-Sheng; Miao, Zi-Qing; Zhao, Ping-Xia; Wang, Zhen; Xiang, Cheng-Bin

    2017-06-05

    Seed germination is a crucial checkpoint for plant survival under unfavorable environmental conditions. Abscisic acid (ABA) signaling plays a vital role in integrating environmental information to regulate seed germination. It has been well known that MCM1/AGAMOUS/DEFICIENS/SRF (MADS)-box transcription factors are key regulators of seed and flower development in Arabidopsis. However, little is known about their functions in seed germination. Here we report that MADS-box transcription factor AGL21 is a negative regulator of seed germination and post-germination growth by controlling the expression of ABA-INSENSITIVE 5 (ABI5) in Arabidopsis. The AGL21-overexpressing plants were hypersensitive to ABA, salt, and osmotic stresses during seed germination and early post-germination growth, whereas agl21 mutants were less sensitive. We found that AGL21 positively regulated ABI5 expression in seeds. Consistently, genetic analyses showed that AGL21 is epistatic to ABI5 in controlling seed germination. Chromatin immunoprecipitation assays further demonstrated that AGL21 could directly bind to the ABI5 promoter in plant cells. Moreover, we found that AGL21 responded to multiple environmental stresses and plant hormones during seed germination. Taken together, our results suggest that AGL21 acts as a surveillance integrator that incorporates environmental cues and endogenous hormonal signals into ABA signaling to regulate seed germination and early post-germination growth. Copyright © 2017 The Author. Published by Elsevier Inc. All rights reserved.

  7. Protecting workers from pathogens. Employers must act now to comply with OSHA's new standard on bloodborne pathogens.

    Science.gov (United States)

    White, C L

    1992-04-01

    A new standard set forth by the Occupational Safety and Health Administration (OSHA) requires healthcare employers to implement sweeping new controls in areas such as record keeping, engineering, hazard prevention, and work practice. Through the bloodborne pathogen standard, which went into effect on March 6, OSHA acknowledges that healthcare workers face significant health risks as a result of occupational exposure to blood and other infectious materials. Although most prudent healthcare providers already adhere to the Centers for Disease Control's universal precautions, the OSHA regulations include several additional mandatory measures that are more specific and stringent. The additional measures include the development of an exposure control plan, procedures for responding to an employee's exposure to bloodborne pathogens, the implementation of certain engineering and work practice controls to eliminate or minimize on-the-job exposure risks, and the provision of personal protective equipment and information and training programs. OSHA estimates that the greatest cost component of implementing procedures to bring a facility into compliance is attributable to the purchase of personal protective equipment. Although the costs of compliance are substantial, OSHA has estimated that these costs represent less than 1 percent of the healthcare industry's annual revenues. Violation of the bloodborne pathogen standard may result in penalties of up to $70,000, depending on the severity of the infraction. Criminal penalties are also possible for willful violations that result in worker death.

  8. Nitric oxide acts as a positive regulator to induce metamorphosis of the ascidian Herdmania momus.

    Science.gov (United States)

    Ueda, Nobuo; Degnan, Sandie M

    2013-01-01

    Marine invertebrates commonly have a biphasic life cycle in which the metamorphic transition from a pelagic larva to a benthic post-larva is mediated by the nitric oxide signalling pathway. Nitric oxide (NO) is synthesised by nitric oxide synthase (NOS), which is a client protein of the molecular chaperon heat shock protein 90 (HSP90). It is notable, then, that both NO and HSP90 have been implicated in regulating metamorphosis in marine invertebrates as diverse as urochordates, echinoderms, molluscs, annelids, and crustaceans. Specifically, the suppression of NOS activity by the application of either NOS- or HSP90-inhibiting pharmacological agents has been shown consistently to induce the initiation of metamorphosis, leading to the hypothesis that a negative regulatory role of NO is widely conserved in biphasic life cycles. Further, the induction of metamorphosis by heat-shock has been demonstrated for multiple species. Here, we investigate the regulatory role of NO in induction of metamorphosis of the solitary tropical ascidian, Herdmania momus. By coupling pharmacological treatments with analysis of HmNOS and HmHSP90 gene expression, we present compelling evidence of a positive regulatory role for NO in metamorphosis of this species, in contrast to all existing ascidian data that supports the hypothesis of NO as a conserved negative regulator of metamorphosis. The exposure of competent H. momus larvae to a NOS inhibitor or an NO donor results in an up-regulation of NOS and HSP90 genes. Heat shock of competent larvae induces metamorphosis in a temperature dependent manner, up to a thermal tolerance that approaches 35°C. Both larval/post-larval survival and the appearance of abnormal morphologies in H. momus post-larvae reflect the magnitude of up-regulation of the HSP90 gene in response to heat-shock. The demonstrated role of NO as a positive metamorphic regulator in H. momus suggests the existence of inter-specific adaptations of NO regulation in ascidian

  9. Potential Impact of Clean Air Act Regulations on Nitrogen Fate and Transport in the Neuse River Basin: a Modeling Investigation Using CMAQ and SWAT

    Science.gov (United States)

    There has been extensive analysis of Clean Air Act Amendment (CAAA) regulation impacts to changes in atmospheric nitrogen deposition; however, few studies have focused on watershed nitrogen transfer particularly regarding long-term predictions. In this study, we investigated impa...

  10. 5 CFR 1900.100 - Cross-references to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Cross-references to employee ethical... ethical conduct standards and financial disclosure regulations. Officers and employees of the Appalachian Regional Commission Federal Staff are subject to the Standards of Ethical Conduct for Employees of the...

  11. 12 CFR 336.1 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Cross-reference to employee ethical conduct... and Conduct § 336.1 Cross-reference to employee ethical conduct standards and financial disclosure... Branch-wide Standards of Ethical Conduct at 5 CFR part 2635, the Corporation regulation at 5 CFR part...

  12. 12 CFR 601.100 - Cross-references to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Cross-references to employee ethical conduct... employee ethical conduct standards and financial disclosure regulations. Board members, officers, and other employees of the Farm Credit Administration are subject to the Standards of Ethical Conduct for Employees of...

  13. 10 CFR 1010.102 - Cross-references to employee ethical conduct standards, financial disclosure regulations, and...

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Cross-references to employee ethical conduct standards... ENERGY (GENERAL PROVISIONS) CONDUCT OF EMPLOYEES § 1010.102 Cross-references to employee ethical conduct... Standards of Ethical Conduct for Employees of the Executive Branch at 5 CFR part 2635, the DOE regulation at...

  14. 49 CFR 1019.1 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Cross-reference to employee ethical conduct... Cross-reference to employee ethical conduct standards and financial disclosure regulations. Members and employees of the Surface Transportation Board also should refer to the executive branch Standards of Ethical...

  15. 5 CFR 1633.1 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Cross-reference to employee ethical... ethical conduct standards and financial disclosure regulations. Employees of the Federal Retirement Thrift Investment Board (Board) are subject to the executive branch-wide Standards of Ethical conduct at 5 CFR part...

  16. 22 CFR 705.101 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cross-reference to employee ethical conduct... INVESTMENT CORPORATION ADMINISTRATIVE PROVISIONS EMPLOYEE ETHICAL CONDUCT STANDARDS AND FINANCIAL DISCLOSURE REGULATIONS § 705.101 Cross-reference to employee ethical conduct standards and financial disclosure...

  17. 39 CFR 3000.735-101 - Cross-reference to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Cross-reference to employee ethical conduct... employee ethical conduct standards and financial disclosure regulations. Employees of the Postal Regulatory Commission (Commission) are subject and should refer to the executive branch-wide Standards of Ethical...

  18. 5 CFR 1300.1 - Cross-reference to employees ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Cross-reference to employees ethical conduct standards and financial disclosure regulations. 1300.1 Section 1300.1 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET ADMINISTRATIVE PROCEDURES STANDARDS OF CONDUCT § 1300.1 Cross-reference...

  19. 16 CFR 1030.101 - Cross-references to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... PRODUCT SAFETY COMMISSION GENERAL EMPLOYEE STANDARDS OF CONDUCT General § 1030.101 Cross-references to employee ethical conduct standards and financial disclosure regulations. Employees of the Consumer Product... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Cross-references to employee ethical conduct...

  20. Contract Labour (Regulation and Abolition) Act 1970 and labour market flexibility: An exploratory assessment of contract labour use in India's formal manufacturing

    OpenAIRE

    Das, Deb Kusum; Choudhury, Homagni; Singh, Jaivir

    2015-01-01

    One particularly significant piece of labour legislation in India is the Contract Labour (Regulation and Abolition) Act, 1970 (CLA,1970), which regulates labour hired by firms through the offices of a labour contractor - such labour being referred to as 'contract' labour in India. This paper seeks to examine this Act and its implication for manufacturing employment in India. While empirical evidence seems to indicate the presence of large number of 'contract' workers in the Indian manufacturi...

  1. Factories Act 1961, Ionizing Radiations (Unsealed Radioactive Substances) Regulations 1968, Certificate of Approval No.1 (General)

    International Nuclear Information System (INIS)

    1969-01-01

    Under the Ionising Radiations (Unsealed Radioactive Substances) Regulations No. 780 of 1968, the Chief Inspector of Factories has wide powers to ensure the protection of workers. By this Certificate he approved, for the purpose of measuring radiation doses, any radiation dosemeter, based on the phenomenon of radiation-induced thermoluminescence, supplied by an approved laboratory. (NEA) [fr

  2. 78 FR 27308 - Loan Originator Compensation Requirements Under the Truth In Lending Act (Regulation Z...

    Science.gov (United States)

    2013-05-10

    ... consumer financial laws, to consider the potential benefits and costs of regulation to consumers and... effective date of Sec. 1026.36(i) would also delay the consumer benefit that would result from allowing the..., 2013 / Proposed Rules#0;#0; [[Page 27308

  3. 75 FR 19241 - Financial Crimes Enforcement Network; Amendment to the Bank Secrecy Act Regulations; Defining...

    Science.gov (United States)

    2010-04-14

    ... definition of mutual fund in the rule requiring mutual funds to establish anti-money laundering (``AML...-money laundering programs and compliance procedures.\\1\\ Regulations implementing the BSA appear at 31... transactions.\\7\\ \\5\\ Anti-Money Laundering Programs for Mutual Funds, 67 FR 21117 (April 29, 2002); Customer...

  4. Regulations under the Radioactive Substances Act of 1958, No. 115, 1961

    International Nuclear Information System (INIS)

    1961-01-01

    These very detailed regulations lay down the licensing system for the use of radioactive materials. They provide for monitoring and control of radiation and radiation contamination, storage, labelling and transport of radioactive materials and also for the disposal of radioactive waste. (NEA) [fr

  5. 78 FR 58202 - Federal Tort Claims Act (FTCA) Medical Malpractice Program Regulations: Clarification of FTCA...

    Science.gov (United States)

    2013-09-23

    ...) Medical Malpractice Program Regulations: Clarification of FTCA Coverage for Services Provided to Non... not limit coverage to childhood vaccinations; and (3) To add the following new example as subsection 6... that have substantial direct effects on the states, the relationship between the national government...

  6. 77 FR 60620 - Update of Existing Privacy Act-NASA Regulations

    Science.gov (United States)

    2012-10-04

    ... rules and regulations governing the manner of its operations and the exercise of the powers vested in it..., public health and safety effects, distributive impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs, of harmonizing rules, and of promoting...

  7. 76 FR 10516 - Transfer and Reorganization of Bank Secrecy Act Regulations-Technical Amendment.

    Science.gov (United States)

    2011-02-25

    ... violate provisions of Title 12 of the Code of Federal Regulations. PART 1021--RULES FOR CASINOS AND CARD CLUBS 0 3. The authority citation for part 1021 is added to read as follows: Authority: 12 U.S.C. 1829b... CREDIT CARD SYSTEMS 0 17. The authority citation for part 1028 is added to read as follows: Authority: 12...

  8. Product unconformable in the light of legal regulations and the ISO 9001:2000 standards

    Directory of Open Access Journals (Sweden)

    Justyna Górna

    2009-01-01

    Full Text Available The supervision of unconformable product is a key problem in the era of globalization. In Poland the supervision of safety product has been entrusted to the President of the Office of Competition and Consumer Protection. The agency supporting its activities is the Trade Inspection. Growing popularity of the quality systems conformable with the ISO 9000 standard caused that they have been included in the EU regulations as criteria of assessment of conformability with requirements. The certificate of the quality management system is indispensable for companies for functioning in many market areas. One should remember that quality management system will help the company to supervise unconformable products only when it really functions and is not just on paper. Only then it will function efficiently.

  9. The Patient Protection and Affordable Care Act and the regulation of the health insurance industry.

    Science.gov (United States)

    Jha, Saurabh; Baker, Tom

    2012-12-01

    The Patient Protection and Affordable Care Act is a comprehensive and multipronged reform of the US health care system. The legislation makes incremental changes to Medicare, Medicaid, and the market for employer-sponsored health insurance. However, it makes substantial changes to the market for individual and small-group health insurance. The purpose of this article is to introduce the key regulatory reforms in the market for individual and small-group health insurance and explain how these reforms tackle adverse selection and risk classification and improve access to health care for the hitherto uninsured or underinsured population. Copyright © 2012 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  10. A review of state regulations that exceed those of the federal Resource Conservation and Recovery Act (RCRA)

    International Nuclear Information System (INIS)

    Coutant, C.C.; Heckman, C.L.

    1988-04-01

    This report identifies and provides information on state hazardous waste management programs and regulations in states where the US Department of Energy (DOE) has facilities. The objective is to describe for the DOE defense program and its contractors how state requirements are more stringent than the federal regulations under the Resource Conservation and Recovery Act (RCRA). DOE defense programs are located in 13 of the 50 states. Most of these states have regulations that are essentially equivalent to the federal RCRA requirements as they existed prior to the 1984 amendments, but their regulations are, in most instances, more stringment than the federal requirements. Differences are both substantive and procedural, and they are summarized and tabulated herein. All but three of these 13 states have been granted Final Authorization from the US Environmental Protection Agency (EPA) to operate their own hazardous waste management program in accord with the federal RCRA program prior to the 1984 amendments; two of the three others have some stage of Interim Authorization. EPA currently administers all of the provisions of the 1984 amendments, including requirements for corrective action under Sect. 3004(u). Two states, Colorado and Tennessee, have been granted revisions to their Final Authorizations delegating responsibility for the hazardous wastes. Responsible state agencies (with appropriate telephone numbers) are indicated, as are the relevant laws and current regulatory statutes

  11. 76 FR 70037 - Federal Regulations; OMB Circulars, OFPP Policy Letters, and CASB Cost Accounting Standards...

    Science.gov (United States)

    2011-11-10

    ... Circulars, OFPP Policy Letters, and CASB Cost Accounting Standards Included in the Semiannual Agenda of..., and Cost Accounting Standards Board (CASB) Cost Accounting Standards. DATES: The withdrawal is...

  12. Modelling air quality according to INSPIRE data specifications, ISO standards and national regulations

    Directory of Open Access Journals (Sweden)

    Pachelski Wojciech

    2017-12-01

    Full Text Available Protection of the environment is an activity of many institutions, organizations and communities from global to regional and local scales. Any activity in this area needs structured database records, using advanced methodology, given, among others, in INSPIRE documents, ISO standards of 19100 series, and national regulations. The goal of this paper is to analyse both the legal provisions related to the air quality and also data sources associated with the prevention of air pollution. Furthermore, the UML application schema of the spatial data related to the air protection is proposed, for the use by urban planners. Also, the overview of the methodology of geographic information is given, including the Unified Modelling Language (UML, as well as the basic concepts of conceptual models within the INSPIRE project. The study is based on the relevant literature and documents, as well as on the expert knowledge gained through urban planning practice, as well as on the analysis of the spatial planning regulations. The UML application schema for different aspects related to the air protection, as presented in this paper, is an example of how to use the methodology also in other fields of the environment protection. Spatial planners know how to improve the air quality, but in the present state of law they often suffer from the lack of planning tools for real actions. In the spatial planners work an important issue are data that allow a thorough analysis of the area.

  13. Legal status of minister's notices and technology standards of 'Korea institute of nuclear safety'(KINS) to regulate nuclear safety

    International Nuclear Information System (INIS)

    Jung, S. K.; Jung, M. M.; Kim, S. W.; Jang, K. H.; Oh, B. J.

    2003-01-01

    Concerning nuclear safety or technology standards, each of 'notices' issued by minister of science and technology(MOST) empowered by law of its regulation is obviously forceful as a law, if not all. But the standards made by the chief of Korea institute of nuclear safety(KINS) to meet the tasks entrusted to KINS by MOST is only conditionally forceful as a law, that is, on the condition that law or regulation empowered the chief of KINS to make nuclear safety and/or technology standards

  14. Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development.

    Directory of Open Access Journals (Sweden)

    Jennifer C Chang

    2011-08-01

    Full Text Available Streptococcus pyogenes (Group A Streptococcus, GAS is an important human commensal that occasionally causes localized infections and less frequently causes severe invasive disease with high mortality rates. How GAS regulates expression of factors used to colonize the host and avoid immune responses remains poorly understood. Intercellular communication is an important means by which bacteria coordinate gene expression to defend against host assaults and competing bacteria, yet no conserved cell-to-cell signaling system has been elucidated in GAS. Encoded within the GAS genome are four rgg-like genes, two of which (rgg2 and rgg3 have no previously described function. We tested the hypothesis that rgg2 or rgg3 rely on extracellular peptides to control target-gene regulation. We found that Rgg2 and Rgg3 together tightly regulate two linked genes encoding new peptide pheromones. Rgg2 activates transcription of and is required for full induction of the pheromone genes, while Rgg3 plays an antagonistic role and represses pheromone expression. The active pheromone signals, termed SHP2 and SHP3, are short and hydrophobic (DI[I/L]IIVGG, and, though highly similar in sequence, their ability to disrupt Rgg3-DNA complexes were observed to be different, indicating that specificity and differential activation of promoters are characteristics of the Rgg2/3 regulatory circuit. SHP-pheromone signaling requires an intact oligopeptide permease (opp and a metalloprotease (eep, supporting the model that pro-peptides are secreted, processed to the mature form, and subsequently imported to the cytoplasm to interact directly with the Rgg receptors. At least one consequence of pheromone stimulation of the Rgg2/3 pathway is increased biogenesis of biofilms, which counteracts negative regulation of biofilms by RopB (Rgg1. These data provide the first demonstration that Rgg-dependent quorum sensing functions in GAS and substantiate the role that Rggs play as peptide

  15. Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

    Science.gov (United States)

    Sugioka, Kenji; Hamill, Danielle R; Lowry, Joshua B; McNeely, Marie E; Enrick, Molly; Richter, Alyssa C; Kiebler, Lauren E; Priess, James R; Bowerman, Bruce

    2017-01-01

    The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the centriolar localization of the other components in C. elegans and in humans. However, the molecular basis for SPD-2 centriolar localization remains unknown. Here, we describe a new centriole component, the coiled-coil protein SAS-7, as a regulator of centriole duplication, assembly and elongation. Intriguingly, our genetic data suggest that SAS-7 is required for daughter centrioles to become competent for duplication, and for mother centrioles to maintain this competence. We also show that SAS-7 binds SPD-2 and regulates SPD-2 centriolar recruitment, while SAS-7 centriolar localization is SPD-2-independent. Furthermore, pericentriolar material (PCM) formation is abnormal in sas-7 mutants, and the PCM-dependent induction of cell polarity that defines the anterior-posterior body axis frequently fails. We conclude that SAS-7 functions at the earliest step in centriole duplication yet identified and plays important roles in the orchestration of centriole and PCM assembly. DOI: http://dx.doi.org/10.7554/eLife.20353.001 PMID:28092264

  16. Restructuring of technical standards for regulation of nuclear power plants in Japan

    International Nuclear Information System (INIS)

    Takehiko Nakamura; Masahiro Aoki; Kiyoshi Takasaka; Yukio Hirano; Eiji Hiraoka; Mikio Kurihara; Junichi Morita; Zenichi Ogiso; Yoshihiko Nishiwaki

    2005-01-01

    Regulatory requirements for nuclear power plants (NPPs) have been reviewed and restructured in Japan, in order to accommodate recent technical progress in a timely manner. In this new regulatory process, the governmental technical requirements are modified to performance specifications and the consensus codes and standards established by academic and public societies are being used as prescriptive specifications to realize the performance. As a first step, a fitness-rule to evaluate structural integrity of the components having cracks was introduced into the Japanese regulatory rules in Oct. 2003. 'Rules on Fitness-for-Service for Nuclear Power Plants' by the Japan Society of Mechanical Engineers (JSME) was utilized as a prescriptive specification for in-service-inspections and for the integrity evaluation of the components with stress corrosion cracks and fatigue cracks. The process is being extended to other requirements for structural design and construction of mechanical components and concrete containments, as well as requirements for welding. Prescriptive specifications for the requirements by the JSME and other consensus codes have been technically reviewed by a regulatory body, the Nuclear and Industrial Safety Agency, and specified as regulatory standards for the licensing procedure. In the course of the review, consistency and coverage of the requirements were examined against the Safety Design Guidelines by the Nuclear Safety Commission and the safety requirements for design of nuclear power plant by the International Atomic Energy Agency, NS-R-1. Additional requirements against the stress corrosion cracking, hydrogen accumulation, high-cycle thermal fatigue, etc. are being specified in the requirements to prevent troubles experienced in NPPs in Japan and overseas. This paper describes outlines of the on-going activities restructuring the technical standards for regulation of NPPs in Japan. (authors)

  17. Regulations implementing the Byrd Amendments to the Black Lung Benefits Act: determining coal miners' and survivors' entitlement to benefits. Final rule.

    Science.gov (United States)

    2013-09-25

    This final rule revises the Black Lung Benefits Act (BLBA or Act) regulations to implement amendments made by the Patient Protection and Affordable Care Act (ACA). The ACA amended the BLBA in two ways. First, it revived a rebuttable presumption of total disability or death due to pneumoconiosis for certain claims. Second, it reinstituted automatic entitlement to benefits for certain eligible survivors of coal miners whose lifetime benefit claims were awarded because they were totally disabled due to pneumoconiosis. These regulations clarify how the statutory presumption may be invoked and rebutted and the application and scope of the survivor-entitlement provision. The rule also eliminates several unnecessary or obsolete provisions.

  18. Reduced nicotine product standards for combustible tobacco: building an empirical basis for effective regulation.

    Science.gov (United States)

    Donny, Eric C; Hatsukami, Dorothy K; Benowitz, Neal L; Sved, Alan F; Tidey, Jennifer W; Cassidy, Rachel N

    2014-11-01

    Both the Tobacco Control Act in the U.S. and Article 9 of the Framework Convention on Tobacco Control enable governments to directly address the addictiveness of combustible tobacco by reducing nicotine through product standards. Although nicotine may have some harmful effects, the detrimental health effects of smoked tobacco are primarily due to non-nicotine constituents. Hence, the health effects of nicotine reduction would likely be determined by changes in behavior that result in changes in smoke exposure. Herein, we review the current evidence on nicotine reduction and discuss some of the challenges in establishing the empirical basis for regulatory decisions. To date, research suggests that very low nicotine content cigarettes produce a desirable set of outcomes, including reduced exposure to nicotine, reduced smoking, and reduced dependence, without significant safety concerns. However, much is still unknown, including the effects of gradual versus abrupt changes in nicotine content, effects in vulnerable populations, and impact on youth. A coordinated effort must be made to provide the best possible scientific basis for regulatory decisions. The outcome of this effort may provide the foundation for a novel approach to tobacco control that dramatically reduces the devastating health consequences of smoked tobacco. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. The Texas space flight liability act and efficient regulation for the private commercial space flight era

    Science.gov (United States)

    Johnson, Christopher D.

    2013-12-01

    In the spring of 2011, the American state of Texas passed into law an act limiting the liability of commercial space flight entities. Under it, those companies would not be liable for space flight participant injuries, except in cases of intentional injury or injury proximately caused by the company's gross negligence. An analysis within the framework of international and national space law, but especially informed by the academic discipline of law and economics, discusses the incentives of all relevant parties and attempts to understand whether the law is economically "efficient" (allocating resources so as to yield maximum utility), and suited to further the development of the fledgling commercial suborbital tourism industry. Insights into the Texas law are applicable to other states hoping to foster commercial space tourism and considering space tourism related legislation.

  20. Cyclic AMP Receptor Protein Acts as a Transcription Regulator in Response to Stresses in Deinococcus radiodurans.

    Directory of Open Access Journals (Sweden)

    Su Yang

    Full Text Available The cyclic AMP receptor protein family of transcription factors regulates various metabolic pathways in bacteria, and also play roles in response to environmental changes. Here, we identify four homologs of the CRP family in Deinococcus radiodurans, one of which tolerates extremely high levels of oxidative stress and DNA-damaging reagents. Transcriptional levels of CRP were increased under hydrogen peroxide (H2O2 treatment during the stationary growth phase, indicating that CRPs function in response to oxidative stress. By constructing all CRP single knockout mutants, we found that the dr0997 mutant showed the lowest tolerance toward H2O2, ultraviolet radiation, ionizing radiation, and mitomycin C, while the phenotypes of the dr2362, dr0834, and dr1646 mutants showed slight or no significant differences from those of the wild-type strain. Taking advantage of the conservation of the CRP-binding site in many bacteria, we found that transcription of 18 genes, including genes encoding chromosome-partitioning protein (dr0998, Lon proteases (dr0349 and dr1974, NADH-quinone oxidoreductase (dr1506, thiosulfate sulfurtransferase (dr2531, the DNA repair protein UvsE (dr1819, PprA (dra0346, and RecN (dr1447, are directly regulated by DR0997. Quantitative real-time polymerase chain reaction (qRT-PCR analyses showed that certain genes involved in anti-oxidative responses, DNA repair, and various cellular pathways are transcriptionally attenuated in the dr0997 mutant. Interestingly, DR0997 also regulate the transcriptional levels of all CRP genes in this bacterium. These data suggest that DR0997 contributes to the extreme stress resistance of D. radiodurans via its regulatory role in multiple cellular pathways, such as anti-oxidation and DNA repair pathways.

  1. Syk Tyrosine Kinase Acts as a Pancreatic Adenocarcinoma Tumor Suppressor by Regulating Cellular Growth and Invasion

    OpenAIRE

    Layton, Tracy; Stalens, Cristel; Gunderson, Felizza; Goodison, Steve; Silletti, Steve

    2009-01-01

    We have identified the nonreceptor tyrosine kinase syk as a marker of differentiation/tumor suppressor in pancreatic ductal adenocarcinoma (PDAC). Syk expression is lost in poorly differentiated PDAC cells in vitro and in situ, and stable reexpression of syk in endogenously syk-negative Panc1 (Panc1/syk) cells retarded their growth in vitro and in vivo and reduced anchorage-independent growth in vitro. Panc1/syk cells exhibited a more differentiated morphology and down-regulated cyclin D1, ak...

  2. The Food Industry and Self-Regulation: Standards to Promote Success and to Avoid Public Health Failures

    Science.gov (United States)

    Sharma, Lisa L.; Teret, Stephen P.

    2010-01-01

    Threatened by possible government regulation and critical public opinion, industries often undertake self-regulatory actions, issue statements of concern for public welfare, and assert that self-regulation is sufficient to protect the public. The food industry has made highly visible pledges to curtail children's food marketing, sell fewer unhealthy products in schools, and label foods in responsible ways. Ceding regulation to industry carries opportunities but is highly risky. In some industries (e.g., tobacco), self-regulation has been an abject failure, but in others (e.g., forestry and marine fisheries), it has been more successful. We examined food industry self-regulation in the context of other self-regulatory successes and failures and defined 8 standards that should be met if self-regulation is to be effective. PMID:20019306

  3. A novel branched chain amino acids responsive transcriptional regulator, BCARR, negatively acts on the proteolytic system in Lactobacillus helveticus.

    Directory of Open Access Journals (Sweden)

    Taketo Wakai

    Full Text Available Transcriptional negative regulation of the proteolytic system of Lactobacillus helveticus CM4 in response to amino acids seems to be very important for the control of antihypertensive peptide production; however, it remains poorly understood. A 26-kDa protein with N-terminal cystathionine β-synthase domains (CBS domain protein, which seems to be involved in the regulatory system, was purified by using a DNA-sepharose bound 300-bp DNA fragment corresponding to the upstream regions of the six proteolytic genes that are down-regulated by amino acids. The CBS domain protein bound to a DNA fragment corresponding to the region upstream of the pepV gene in response to branched chain amino acids (BCAAs. The expression of the pepV gene in Escherichia coli grown in BCAA-enriched medium was repressed when the CBS domain protein was co-expressed. These results reveal that the CBS domain protein acts as a novel type of BCAA-responsive transcriptional regulator (BCARR in L. helveticus. From comparative analysis of the promoter regions of the six proteolysis genes, a palindromic AT-rich motif, 5'-AAAAANNCTWTTATT-3', was predicted as the consensus DNA motif for the BCARR protein binding. Footprint analysis using the pepV promotor region and gel shift analyses with the corresponding short DNA fragments strongly suggested that the BCARR protein binds adjacent to the pepV promoter region and affects the transcription level of the pepV gene in the presence of BCAAs. Homology search analysis of the C-terminal region of the BCARR protein suggested the existence of a unique βαββαβ fold structure that has been reported in a variety of ACT (aspartate kinase-chorismate mutase-tyrA domain proteins for sensing amino acids. These results also suggest that the sensing of BCAAs by the ACT domain might promote the binding of the BCARR to DNA sequences upstream of proteolysis genes, which affects the gene expression of the proteolytic system in L. helveticus.

  4. Ca2+ sparks act as potent regulators of excitation-contraction coupling in airway smooth muscle.

    Science.gov (United States)

    Zhuge, Ronghua; Bao, Rongfeng; Fogarty, Kevin E; Lifshitz, Lawrence M

    2010-01-15

    Ca2+ sparks are short lived and localized Ca2+ transients resulting from the opening of ryanodine receptors in sarcoplasmic reticulum. These events relax certain types of smooth muscle by activating big conductance Ca2+-activated K+ channels to produce spontaneous transient outward currents (STOCs) and the resultant closure of voltage-dependent Ca2+ channels. But in many smooth muscles from a variety of organs, Ca2+ sparks can additionally activate Ca2+-activated Cl(-) channels to generate spontaneous transient inward current (STICs). To date, the physiological roles of Ca2+ sparks in this latter group of smooth muscle remain elusive. Here, we show that in airway smooth muscle, Ca2+ sparks under physiological conditions, activating STOCs and STICs, induce biphasic membrane potential transients (BiMPTs), leading to membrane potential oscillations. Paradoxically, BiMPTs stabilize the membrane potential by clamping it within a negative range and prevent the generation of action potentials. Moreover, blocking either Ca2+ sparks or hyperpolarization components of BiMPTs activates voltage-dependent Ca2+ channels, resulting in an increase in global [Ca2+](i) and cell contraction. Therefore, Ca2+ sparks in smooth muscle presenting both STICs and STOCs act as a stabilizer of membrane potential, and altering the balance can profoundly alter the status of excitability and contractility. These results reveal a novel mechanism underlying the control of excitability and contractility in smooth muscle.

  5. SOX17 Regulates Cholangiocyte Differentiation and Acts as a Tumor Suppressor in Cholangiocarcinoma

    DEFF Research Database (Denmark)

    Merino-Azpitarte, M; Lozano, E; Perugorria, M J

    2017-01-01

    /function was evaluated along the differentiation of human induced pluripotent stem cells (iPSC) into cholangiocytes, in the dedifferentiation process of normal human cholangiocytes (NHC) in culture and in cholangiocarcinogenesis. Lentiviruses for SOX17 overexpression or knock-down were used. Gene expression and DNA......BACKGROUND & AIMS: Cholangiocarcinoma (CCA) is a biliary malignancy linked to genetic and epigenetic abnormalities, such as hypermethylation of SOX17 promoter. Here, the role of SOX17 in cholangiocyte differentiation and cholangiocarcinogenesis was studied. METHODS: SOX17 expression...... methylation profiling were performed. RESULTS: SOX17 expression is induced in the last stage of cholangiocyte differentiation from iPSC and regulates the acquisition of biliary markers. SOX17 becomes downregulated in NHC undergoing dedifferentiation; experimental SOX17 knock-down in differentiated NHC...

  6. 77 FR 69441 - Federal Acquisition Regulation; Information Collection; Cost Accounting Standards Administration

    Science.gov (United States)

    2012-11-19

    ...; Information Collection; Cost Accounting Standards Administration AGENCY: Department of Defense (DOD), General... collection requirement concerning cost accounting standards administration. Public comments are particularly... Information Collection 9000- 0129, Cost Accounting Standards Administration by any of the following methods...

  7. Standard Compliance: Guidelines to Help State and Alternative Fuel Provider Fleets Meet Their Energy Policy Act Requirements, 10 CFR Part 490 (Book)

    Energy Technology Data Exchange (ETDEWEB)

    2014-03-01

    This guidebook addresses the primary requirements of the Alternative Fuel Transportation Program to help state and alternative fuel provider fleets comply with the Energy Policy Act via the Standard Compliance option. It also addresses the topics that covered fleets ask about most frequently.

  8. The Impact of Minimum Energy Performance Standards (MEPS) Regulation on Electricity Saving in Malaysia

    Science.gov (United States)

    Fatihah Salleh, Siti; Eqwan Roslan, Mohd; Isa, Aishah Mohd; Faizal Basri Nair, Mohd; Syafiqah Salleh, Siti

    2018-03-01

    One of Malaysia’s key strategies to promote efficient energy use in the country is to implement the minimum energy performance standards (MEPS) through the Electricity Regulations (Amendment) 2013. Five selected electrical appliances (refrigerator, air conditioner, television, domestic fans and lamp fittings) must comply with MEPS requirement in order to be sold in Malaysian market. Manufacturers, importers or distributors are issued Certificate of Approval (COA) if products are MEPS-compliant. In 2015, 1,215 COAs were issued but the number of MEPS products in the market is unknown. This work collects sales data from major manufacturers to estimate the annual sales of MEPS appliances and the cumulative electricity consumption and electricity saving. It was found that most products sold have 3-star rating and above. By year 2015, total cumulative electricity savings gained from MEPS implementation is 3,645 GWh, with air conditioner being the highest contributor (30%). In the future, it is recommended that more MEPS products and related incentives be introduced to further improve efficiency of energy use in Malaysia.

  9. Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.

    Science.gov (United States)

    Li, Zhenlin; Parlakian, Ara; Coletti, Dario; Alonso-Martin, Sonia; Hourdé, Christophe; Joanne, Pierre; Gao-Li, Jacqueline; Blanc, Jocelyne; Ferry, Arnaud; Paulin, Denise; Xue, Zhigang; Agbulut, Onnik

    2014-11-01

    Synemin, a type IV intermediate filament (IF) protein, forms a bridge between IFs and cellular membranes. As an A-kinase-anchoring protein, it also provides temporal and spatial targeting of protein kinase A (PKA). However, little is known about its functional roles in either process. To better understand its functions in muscle tissue, we generated synemin-deficient (Synm(-) (/-)) mice. Synm(-) (/-) mice displayed normal development and fertility but showed a mild degeneration and regeneration phenotype in myofibres and defects in sarcolemma membranes. Following mechanical overload, Synm(-) (/-) mice muscles showed a higher hypertrophic capacity with increased maximal force and fatigue resistance compared with control mice. At the molecular level, increased remodelling capacity was accompanied by decreased myostatin (also known as GDF8) and atrogin (also known as FBXO32) expression, and increased follistatin expression. Furthermore, the activity of muscle-mass control molecules (the PKA RIIα subunit, p70S6K and CREB1) was increased in mutant mice. Finally, analysis of muscle satellite cell behaviour suggested that the absence of synemin could affect the balance between self-renewal and differentiation of these cells. Taken together, our results show that synemin is necessary to maintain membrane integrity and regulates signalling molecules during muscle hypertrophy. © 2014. Published by The Company of Biologists Ltd.

  10. Regulation of DNA replication in irradiated cells by trans-acting factors

    International Nuclear Information System (INIS)

    Wang, Y.; Huq, M.S.; Cheng, X.; Iliakis, G.

    1995-01-01

    We compared DNA replication activity in cytoplasmic extracts prepared from irradiated and nonirradiated HeLa cells using a simian virus 40 (SV40)-based in vitro replication assay. The assay measures semi-conservative DNA replication in a plasmid carrying the SV40 origin of replication and requires SV40 T antigen as the sole noncellular protein. The plasmid DNA used in the replication reaction is never exposed to radiation. We find that replication of plasmid DNA is significantly reduced when cytoplasmic extracts from irradiated cells are used. Since plasmid replication proceeds to completion in extracts from irradiated cells, the observed reduction in the overall replication activity is probably due to a reduction in the efficiency of initiation events. The degree of inhibition of DNA replication after exposure to 10, 30 and 50 Gy X rays as measured in vitro using this assay is similar to that measured in intact cells immediately before processing for extract preparation. These observations are compatible with the induction or activation by ionizing radiation of a factor(s) that inhibits in trans DNA replication. The results contribute to our understanding of the mechanism(s) developed by the cells to regulate DNA replication when exposed to clastogenic agents. Such processes may be of significance in the restoration of DNA integrity, and may define yet another checkpoint operating during S at the level of clusters of replicons. 26 refs., 4 figs

  11. cis- and trans-acting elements of the estrogen-regulated vitellogenin gene B1 of Xenopus laevis.

    Science.gov (United States)

    Wahli, W; Martinez, E; Corthésy, B; Cardinaux, J R

    1989-01-01

    Vitellogenin genes are expressed under strict estrogen control in the liver of female oviparous vertebrates. Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE). In the Xenopus vitellogenin genes B1 and B2 there are two closely adjacent EREs with one or more base substitutions when compared to the consensus ERE GGTCANNNTGACC. On their own, these degenerated elements have only a low or no regulatory capacity at all but act together synergistically to form an estrogen-responsive unit (ERU) with the same strength as the perfect palindromic 13 bp element. Analysis of estrogen receptor binding to the gene B1 ERU revealed a cooperative interaction of receptor dimers to the two adjacent imperfect EREs which most likely explains the synergistic stimulation observed in vivo. Furthermore, a promoter activator element located between positions --113 and --42 of the gene B1 and functional in the human MCF-7 and the Xenopus B3.2 cells has been identified and shown to be involved in the high level of induced transcription activity when the ERE is placed at a distance from the promoter. Finally, a hormone-controlled in vitro transcription system derived from Xenopus liver nuclear extracts was exploited to characterize two additional novel cis-acting elements within the vitellogenin gene B1 promoter. One of them, a negative regulatory element (NRE), is responsible for repression of promoter activity in the absence of hormone. The second is related to the NF-I binding site and is required, together with the ERE, to mediate hormonal induction. Moreover, we detected three trans-acting activities in Xenopus liver nuclear extracts that interact with these regions and demonstrated that they participate in the regulation of the expression of the vitellogenin

  12. H.R. 5448: a bill to amend the Atomic Energy Act of 1954, as amended, to reorganize the functions of the Nuclear Regulatory Commission by abolishing the Commission and in its place establishing the Nuclear Regulation and Safety Agency. Introduced in the House of Representatives, Ninety-Ninth Congress, Second Session, August 15, 1986

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The Omnibus Nuclear Safety Act of 1986 amends the Atomic Energy Act of 1954 by replacing the Nuclear Regulatory Commission with a new entity, the Nuclear Regulation and Safety Agency. The purposes are to promote an energy policy that is better coordinated and more consistent with the protection of public health and safety. The new agency would also expedite licensing for construction and operation of nuclear power plants by using pre-approved standardized designs and sites

  13. A guide for determining compliance with the Clean Air Act Standards for radionuclide emissions from NRC-licensed and non-DOE federal facilities (Rev. 1)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-10-01

    The Environmental Protection Agency (EPA) issued standards under Section 112 of the Clean Air Act of February 6, 1985 that limit airborne emissions of radionuclides to the atmosphere. In February 1989 these standards were re proposed , and in November 1989 final standards may be promulgated. This document provides guidance for determining compliance with one of the National Emissions for Hazardous Air Pollutants covering facilities that are licensed by NRC, and federal facilities not operated by the DOE, that could emit radionuclides to the ai00.

  14. 76 FR 60357 - Federal Regulations; OMB Circulars, OFPP Policy Letters, and CASB Cost Accounting Standards...

    Science.gov (United States)

    2011-09-29

    ... derived from 41 U.S.C. 1501. Cost Accounting Standards are rules governing the measurement, assignment... Circulars, OFPP Policy Letters, and CASB Cost Accounting Standards Included in the Semiannual Agenda of..., and Cost Accounting Standards Board (CASB) Cost Accounting Standards. OMB Circulars and OFPP Policy...

  15. Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription.

    Science.gov (United States)

    Dalla Rosa, Ilaria; Zhang, Hongliang; Khiati, Salim; Wu, Xiaolin; Pommier, Yves

    2017-12-08

    Mitochondrial DNA (mtDNA) is essential for cell viability because it encodes subunits of the respiratory chain complexes. Mitochondrial topoisomerase IB (TOP1MT) facilitates mtDNA replication by removing DNA topological tensions produced during mtDNA transcription, but it appears to be dispensable. To test whether cells lacking TOP1MT have aberrant mtDNA transcription, we performed mitochondrial transcriptome profiling. To that end, we designed and implemented a customized tiling array, which enabled genome-wide, strand-specific, and simultaneous detection of all mitochondrial transcripts. Our technique revealed that Top1mt KO mouse cells process the mitochondrial transcripts normally but that protein-coding mitochondrial transcripts are elevated. Moreover, we found discrete long noncoding RNAs produced by H-strand transcription and encompassing the noncoding regulatory region of mtDNA in human and murine cells and tissues. Of note, these noncoding RNAs were strongly up-regulated in the absence of TOP1MT. In contrast, 7S DNA, produced by mtDNA replication, was reduced in the Top1mt KO cells. We propose that the long noncoding RNA species in the D-loop region are generated by the extension of H-strand transcripts beyond their canonical stop site and that TOP1MT acts as a topological barrier and regulator for mtDNA transcription and D-loop formation.

  16. Transposition of the basic safety standards. Potential impact on French laws and regulations

    Energy Technology Data Exchange (ETDEWEB)

    Godet, J.L.; Perrin, M.M.; Saad, N.; Bardelay, C. [Autorite de Surete Nucleaire (ASN), Paris (France)

    2013-07-01

    The new proposal for a Council Directive laying down basic safety standards for protection against the dangers arising from exposure to ionising radiation is about to be adopted. Member States shall bring into force the laws, regulations and administrative provisions necessary to comply with this Directive within 4 years after adoption of the final text. As far as France is concerned, these evolutions will mainly impact the labour code (for occupational issues) and the public health code for both legal and regulatory requirements. The most significant improvements of the current version of the project are the introduction of graded approach to regulatory control and the enhancement of requirements for protection against natural radiation sources (in particular exposure to radon and naturally occurring radioactive material). This project also aims at achieving a better harmonisation between Member States for topics such as the organization of radiation protection for workers, the justification of medical devices and non-medical imaging exposure situations. ASN has already identified major issues for the transposition of the Directive concerning both French laws and regulations. Main topics should concern the impact of ICRP terminology (planned exposure situation, existing exposure situation versus lasting exposure situation, reference level versus maximum activity level for exposure to radon..) and the extension of both justification and optimisation principles to new activities involving natural radiation sources, such as industries processing naturally occurring radioactive material. Furthermore, France will have to decide whether it will adjust some positions about the prohibition of nonmedical imaging exposures and the release of materials from regulatory control according to generic values. Indeed, the project mentions the possibility to introduce derogations to those major principles. Finally, and according to the graded approach, the project introduces a new

  17. Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents.

    Directory of Open Access Journals (Sweden)

    Andrea D Olmstead

    2012-01-01

    Full Text Available HCV infection is a major risk factor for liver cancer and liver transplantation worldwide. Overstimulation of host lipid metabolism in the liver by HCV-encoded proteins during viral infection creates a favorable environment for virus propagation and pathogenesis. In this study, we hypothesize that targeting cellular enzymes acting as master regulators of lipid homeostasis could represent a powerful approach to developing a novel class of broad-spectrum antivirals against infection associated with human Flaviviridae viruses such as hepatitis C virus (HCV, whose assembly and pathogenesis depend on interaction with lipid droplets (LDs. One such master regulator of cholesterol metabolic pathways is the host subtilisin/kexin-isozyme-1 (SKI-1--or site-1 protease (S1P. SKI-1/S1P plays a critical role in the proteolytic activation of sterol regulatory element binding proteins (SREBPs, which control expression of the key enzymes of cholesterol and fatty-acid biosynthesis. Here we report the development of a SKI-1/S1P-specific protein-based inhibitor and its application to blocking the SREBP signaling cascade. We demonstrate that SKI-1/S1P inhibition effectively blocks HCV from establishing infection in hepatoma cells. The inhibitory mechanism is associated with a dramatic reduction in the abundance of neutral lipids, LDs, and the LD marker: adipose differentiation-related protein (ADRP/perilipin 2. Reduction of LD formation inhibits virus assembly from infected cells. Importantly, we confirm that SKI-1/S1P is a key host factor for HCV infection by using a specific active, site-directed, small-molecule inhibitor of SKI-1/S1P: PF-429242. Our studies identify SKI-1/S1P as both a novel regulator of the HCV lifecycle and as a potential host-directed therapeutic target against HCV infection and liver steatosis. With identification of an increasing number of human viruses that use host LDs for infection, our results suggest that SKI-1/S1P inhibitors may allow

  18. Regulated Emissions from Biodiesel Tested in Heavy-Duty Engines Meeting 2004 Emission Standards

    Energy Technology Data Exchange (ETDEWEB)

    McCormick, R. L.; Tennant, C. J.; Hayes, R. R.; Black, S.; Ireland, J.; McDaniel, T.; Williams, A.; Frailey, M.; Sharp, C. A.

    2005-11-01

    Biodiesel produced from soybean oil, canola oil, yellow grease, and beef tallow was tested in two heavy-duty engines. The biodiesels were tested neat and as 20% by volume blends with a 15 ppm sulfur petroleum-derived diesel fuel. The test engines were the following: 2002 Cummins ISB and 2003 DDC Series 60. Both engines met the 2004 U.S. emission standard of 2.5 g/bhp-h NO{sub x}+HC (3.35 g/kW-h) and utilized exhaust gas recirculation (EGR). All emission tests employed the heavy-duty transient procedure as specified in the U.S. Code of Federal Regulations. Reduction in PM emissions and increase in NO{sub x} emissions were observed for all biodiesels in all engines, confirming observations made in older engines. On average PM was reduced by 25% and NO{sub x} increased by 3% for the two engines tested for a variety of B20 blends. These changes are slightly larger in magnitude, but in the same range as observed in older engines. The cetane improver 2-ethyl hexyl nitrate was shown to have no measurable effect on NO{sub x} emissions from B20 in these engines, in contrast to observations reported for older engines. The effect of intake air humidity on NO{sub x} emissions from the Cummins ISB was quantified. The CFR NO{sub x}/humidity correction factor was shown to be valid for an engine equipped with EGR, operating at 1700 m above sea level, and operating on conventional or biodiesel.

  19. 12 CFR 400.101 - Cross-reference to employee financial disclosure and ethical conduct standards regulations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Cross-reference to employee financial disclosure and ethical conduct standards regulations. 400.101 Section 400.101 Banks and Banking EXPORT-IMPORT.... Employees of the Export-Import Bank of the United States (Bank) should refer to: (a) The executive branch...

  20. Hard Work in Soft Regulation: A Discussion of the Social Mechanisms in OHS Management Standards and Possible Dilemmas in the Regulation of Psychosocial Work Environment

    Directory of Open Access Journals (Sweden)

    Pernille Hohnen

    2014-09-01

    Full Text Available Certified occupational health and safety (OHS management systems have become a global instrument in regulation of the work environment. However, their actual impact on OHS—in particular on softer psychosocial issues in the work environment—has been questioned. The most important standard of OHS management is OHSAS 18001, which has recently been supplemented with a British publically available guideline (PAS 1010 focusing specifically on psychosocial risk management. On the basis of the international literature on management standards, the present paper analyses OHSAS 18001 and PAS 1010 in order to understand the mechanism by which they work. The paper takes a social constructionist approach conceptualizing standards and their expected mechanisms as socially constructed—based on a particular kind of knowledge and logic—although they are presented as objective. Such a constructionist approach also emphasizes how standards transform specific work environment problems into generic procedures that can be audited. In the case of OHS standards, both the work environment in general and the psychosocial risks in particular are transformed into simple monocausal auditable relations whereby the complexity of psychosocial work environment issues seems to disappear. The new PAS 1010 guideline, which is particularly focusing on regulation of the psychosocial work environment, only partly succeeds in solving these shortcomings of OHSAS 18001.

  1. Current environmental regulations

    International Nuclear Information System (INIS)

    Martz, M.K.

    1985-01-01

    An overview of the Federal environmental statutes and implementation regulations is provided, including the National Environmental Policy Act, the Clean Air Act, the Clean Water Act, the Safe Drinking Water Act, the Resource Conservation and Recovery Act, the Comprehensive Environmental Response, Compensation, and Liability Act, the Toxic Substances Control Act, the Federal Insecticide, Fungicide, and Rodenticide Act, and the Endangered Species Act. Recent developments which may have a direct impact on waste repository siting and management activities include: final promulgation of National Emission Standards for hazardous Air Pollutants for radionuclides, the DOE-EPA memorandum of understanding which brings mixed radioactive and chemical waste under the requirements of RCRA, and the proposed designation of additional sole source aquifers

  2. Act No. 1240 of 15 December 1971. Regulations concerning the restructuring of the National Nuclear Energy Commission (CNEN)

    International Nuclear Information System (INIS)

    1972-01-01

    This Act which annuls the preceding Act of 1960 with the exception of Sections 12 to 16, confirms the CNEN's responsibilities. As opposed to the previous Act this Act contains provisions concerning the National Institute for Nuclear Physics (INFN). (NEA) [fr

  3. 75 FR 44163 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Science.gov (United States)

    2010-07-28

    ... Under Title XI of the Food, Conservation and Energy Act of 2008; Conduct in Violation of the Act AGENCY... Act and provide for a fairer market place. DATES: We will consider comments we receive by November 22... clarify conditions for industry compliance with the P&S Act and provide for a fairer market place. We have...

  4. An Act to Control and Regulate the Possession, Sale, Transport and Use of Radioactive Substances and the Possession and Use of Certain Apparatus capable of producing Radiation

    International Nuclear Information System (INIS)

    1958-01-01

    This Act covers all activities involving radioactive materials and radiation sources. It sets up a Radiological Advisory Council to advise the Minister responsible for health in Queensland on administration of the Act, regulations made thereunder and on preventing and minimising dangers arising from radioactive materials and radiation sources. It lays down the Council's composition and rules of procedure. The Act also provides for the licensing, control and registration of such materials and sources, including sanctions in case of non-compliance with its provisions. (NEA) [fr

  5. 7 CFR 51.1005 - Standard pack.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946... not more than 10 percent, by count of the fruit in any container may vary more than four-sixteenths of...

  6. 7 CFR 51.1863 - Standard weight.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946... net weight of 15 pounds (6.80 kg) or more, the net weight of the contents shall not be less than the...

  7. 78 FR 15883 - Standard Time Zone Boundaries

    Science.gov (United States)

    2013-03-13

    ...] RIN 2105-AE20 Standard Time Zone Boundaries AGENCY: Office of the Secretary (OST), Department of... time zone boundaries regulations to reflect changes that Congress made to the Uniform Time Act. The... regulations on standard time zone boundaries, 49 CFR Part 71, need to be updated in order to ensure their...

  8. Regulations for the Safe Transport of Radioactive Materials. Vietnam Standard (TCVN 4985-89)

    International Nuclear Information System (INIS)

    1989-01-01

    The regulations were prepared in line with the Safety Regulation for Ionizing Radiations 1988 of Vietnam. Its purpose is to provide requirements in transport of radioactive materials. The exposure levels of transport personnel are determined. The package for different types of materials is regulated. The orders and procedures in transport are defined. In addition, specific requirements for each mean of transport are given. (N.H.A)

  9. Assessing risks and regulating safety standards in the oil and gas industry: the Peruvian experience.

    OpenAIRE

    Arturo Leonardo Vásquez Cordano; Julio Salvador Jácome; Raúl Lizardo García Carpio; Victor Fernández Guzman

    2013-01-01

    Environmental regulation has usually focused on controlling continuous sources of pollution such as CO2 emissions through carbon taxes. However, the 2010 oil spill in the Gulf of Mexico has shown that accidents associated to safety failures can also generate bursts of pollution with serious environmental consequences. Regulating safety conditions to prevent accidents in the oil and gas industry is challenging because public regulators cannot perfectly observe whether firms comply with safety ...

  10. HRS1 Acts as a Negative Regulator of Abscisic Acid Signaling to Promote Timely Germination of Arabidopsis Seeds

    Science.gov (United States)

    Wang, Ran; Liu, Hong; Yang, Huixia; Rodriguez, Pedro L.; Qin, Huanju; Liu, Xin; Wang, Daowen

    2012-01-01

    In this work, we conducted functional analysis of Arabidopsis HRS1 gene in order to provide new insights into the mechanisms governing seed germination. Compared with wild type (WT) control, HRS1 knockout mutant (hrs1-1) exhibited significant germination delays on either normal medium or those supplemented with abscisic acid (ABA) or sodium chloride (NaCl), with the magnitude of the delay being substantially larger on the latter media. The hypersensitivity of hrs1-1 germination to ABA and NaCl required ABI3, ABI4 and ABI5, and was aggravated in the double mutant hrs1-1abi1-2 and triple mutant hrs1-1hab1-1abi1-2, indicating that HRS1 acts as a negative regulator of ABA signaling during seed germination. Consistent with this notion, HRS1 expression was found in the embryo axis, and was regulated both temporally and spatially, during seed germination. Further analysis showed that the delay of hrs1-1 germination under normal conditions was associated with reduction in the elongation of the cells located in the lower hypocotyl (LH) and transition zone (TZ) of embryo axis. Interestingly, the germination rate of hrs1-1 was more severely reduced by the inhibitor of cell elongation, and more significantly decreased by the suppressors of plasmalemma H+-ATPase activity, than that of WT control. The plasmalemma H+-ATPase activity in the germinating seeds of hrs1-1 was substantially lower than that exhibited by WT control, and fusicoccin, an activator of this pump, corrected the transient germination delay of hrs1-1. Together, our data suggest that HRS1 may be needed for suppressing ABA signaling in germinating embryo axis, which promotes the timely germination of Arabidopsis seeds probably by facilitating the proper function of plasmalemma H+-ATPase and the efficient elongation of LH and TZ cells. PMID:22545134

  11. cAMP-CRP acts as a key regulator for the viable but non-culturable state in Escherichia coli.

    Science.gov (United States)

    Nosho, Kazuki; Fukushima, Hiroko; Asai, Takehiro; Nishio, Masahiro; Takamaru, Reiko; Kobayashi-Kirschvink, Koseki Joseph; Ogawa, Tetsuhiro; Hidaka, Makoto; Masaki, Haruhiko

    2018-03-01

    A variety of bacteria, including Escherichia coli, are known to enter the viable but non-culturable (VBNC) state under various stress conditions. During this state, cells lose colony-forming activities on conventional agar plates while retaining signs of viability. Diverse environmental stresses including starvation induce the VBNC state. However, little is known about the genetic mechanism inducing this state. Here, we aimed to reveal the genetic determinants of the VBNC state of E. coli. We hypothesized that the VBNC state is a process wherein specific gene products important for colony formation are depleted during the extended period of stress conditions. If so, higher expression of these genes would maintain colony-forming activities, thereby restraining cells from entering the VBNC state. From an E. coli plasmid-encoded ORF library, we identified genes that were responsible for maintaining high colony-forming activities after exposure to starvation condition. Among these, cpdA encoding cAMP phosphodiesterase exhibited higher performance in the maintenance of colony-forming activities. As cpdA overexpression decreases intracellular cAMP, cAMP or its complex with cAMP-receptor protein (CRP) may negatively regulate colony-forming activities under stress conditions. We confirmed this using deletion mutants lacking adenylate cyclase or CRP. These mutants fully maintained colony-forming activities even after a long period of starvation, while wild-type cells lost most of this activity. Thus, we concluded that the lack of cAMP-CRP effectively retains high colony-forming activities, indicating that cAMP-CRP acts as a positive regulator necessary for the induction of the VBNC state in E. coli.

  12. Setting effective mandatory energy efficiency standards and labelling regulations: A review of best practices in the Asia Pacific region

    International Nuclear Information System (INIS)

    Shi, Xunpeng

    2014-01-01

    Highlights: • S and L regulations are needed to materialize the various benefits of energy efficiency. • S and L regulations can appear in various formats as in the Asia–Pacific region. • Effective regime has to be clear, authoritative, open, and enforceable. • Clear policy, customisation, inclusiveness, transparency and flexibility are desirable. - Abstract: This paper attempts to inform policy makers and legislators on how to set energy efficiency standards and labelling (S and L) regulations. It draws lessons from the literature on S and L regulations in the Asia–Pacific region and from practical experience in drafting the S and L regulations for Brunei Darussalam. The paper proposes necessary components for effective S and L regulations, as follows: clear liabilities, authoritative administration, open principles for technical systems, and enforceable mechanisms. It also recommends some key issues in good practice toward effective S and L regulations, such as policy making in advance, customised legislation, inclusive and transparent legislative procedure, and flexibility in the legislation

  13. Act No. 225 of 17 March 1979 containing regulations on third party liability for damage caused by nuclear incidents; Nuclear Incidents (Third Party Liability) Act

    International Nuclear Information System (INIS)

    1979-01-01

    This Act on nuclear third party liability provides that the maximum amount of liability of the operator of a nuclear installation in the Netherlands is set at 100 million guilders in accordance with the Paris Convention; it also implements the Brussels Supplementary Convention's additional compensation mechanism. The new Act further provides that if damage is suffered on the Netherlands' territory as a result of a nuclear incident for which compensation is payable pursuant to the Brussels Convention or to the Act, and that the funds available for this purpose are insufficient to secure compensation of such damage to an amount of one thousand million guilders, the State shall make available the public funds needed to compensate such damage up to that amount. (NEA) [fr

  14. Bill C-5, an act to amend the radiation emitting devices act

    International Nuclear Information System (INIS)

    1984-01-01

    This Act, entitled Bill C-5, allows for a series of amendments to the Radiation Emitting Devices Act. The amendments relate to regulations concerned with the sale, lease or import, labelling, advertising, packaging, safety standards and inspection of radiation emitting devices

  15. Impacts and Compliance Implementation Plans and Required Deviations for Toxic Substance Control Act (TSCA) Regulation of Double Shell Tanks (DST)

    International Nuclear Information System (INIS)

    MULKEY, C.H.

    2000-01-01

    In May 2000, the U.S. Department of Energy, Office of River Protection (DOE-ORP) and the U.S. Environmental Protection Agency (EPA) held meetings regarding the management of polychlorinated biphenyls (PCBs) in the Hanford tank waste. It was decided that the radioactive waste currently stored in the double-shell tanks (DSTs) contain waste which will become subject to the Toxic Substance Control Act (TSCA) (40 CFR 761). As a result, DOE-ORP directed the River Protection Project tank farm contractor (TFC) to prepare plans for managing the PCB inventory in the DSTs. Two components of the PCB management plans are this assessment of the operational impacts of TSCA regulation and the identifications of deviations from TSCA that are required to accommodate tank farm unique limitations. This plan provides ORP and CH2M HILL Hanford Group, Inc. (CHG) with an outline of TSCA PCB requirements and their applicability to tank farm activities, and recommends a compliance/implementation approach. Where strict compliance is not possible, the need for deviations from TSCA PCB requirements is identified. The purpose of assembling this information is to enhance the understanding of PCB management requirements, identify operational impacts and select impact mitigation strategies. This information should be useful in developing formal agreements with EPA where required

  16. Development in France of nuclear safety technical regulations and standards used in the licensing procedure

    International Nuclear Information System (INIS)

    Lebouleux, P.

    1983-04-01

    Initially, the Commissariat a l'Energie Atomique was the overall structure which encompassed all nuclear activities in France, including those connected with radiological protection and nuclear safety. As other partners appeared, the Authorities have laid down national regulations relative to nuclear installations since 1963. These regulations more particularly provide for the addition of prescriptions with which the applicant must comply to obtain the necessary licenses and the establishment of General Technical Regulations pertaining to nuclear safety. The technical regulation related to nuclear safety in France is made of a set of regulation texts, of a different nature, that define the requirements for the construction, commissioning and operation of nuclear facilities. Simultaneously, the safety authorities (Service Central de Surete des Installations Nucleaires: SCSIN) issue recommendations or guides which are not strictly speaking regulations in the juridical sense; they are called ''Regles Fondamentales de Surete'' (RFS). The RFS set up and detail the conditions, the respect of which is deemed to be complying with the French regulation practice, for the subject to which they relate. Their purpose is to make known rules judged acceptable by safety authorities, thus making the safety review easier. A RFS, or a letter, can also give the result of the examination of the constructor and operator codes (RCC) by safety authorities

  17. A Look Back at the Long Path to Mandating Electric Reliability Standards through the Energy Policy Act of 2005

    Energy Technology Data Exchange (ETDEWEB)

    Young, Ellen Swyler

    2006-07-15

    The Act was the culmination of more than eight years of legislative effort in Congress. During this period, the nation saw the Western electricity crisis of 2000-01, the Sept. 11 attacks, the collapse of Enron, the growth of RTOs, and the August 2003 blackout. Each of these influenced the dynamics of the debate. (author)

  18. 78 FR 69086 - Federal Acquisition Regulation; Submission for OMB Review; Preaward Survey Forms (Standard Forms...

    Science.gov (United States)

    2013-11-18

    .../or business confidential information provided. FOR FURTHER INFORMATION CONTACT: Ms. Cecelia L. Davis... of the information collection would violate the fundamental purposes of the Paperwork Reduction Act... statistics) that were over the simplified acquisition threshold and that did not use FAR part 12 commercial...

  19. Writing standards for performance based building regulations. Conditions to be fulfilled

    NARCIS (Netherlands)

    Scholten, N.P.M.; Walters, W.; Nouwen, R.

    2001-01-01

    The Dutch Building Decree, a general administrative measure based on the Housing Act, is expressed in performance requirements. In each clause the performance requirement is based on a functional definit-ion. This definition expresses the intention of the performance requirement. The performance

  20. 75 FR 35338 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Science.gov (United States)

    2010-06-22

    ... Under Title XI of the Food, Conservation and Energy Act of 2008; Conduct in Violation of the Act AGENCY... fairer market place. DATES: We will consider comments we receive by August 23, 2010. ADDRESSES: We invite... Title XI of the Food, Conservation and Energy Act of 2008 (Farm Bill) (Pub. L. 110-246), Congress...

  1. 29 CFR 1990.152 - Model emergency temporary standard pursuant to section 6(c) of the Act.

    Science.gov (United States)

    2010-07-01

    ... report the following information to the nearest OSHA Area Office for each such workplace: (1) The address... (insert section number of standard) (a) Scope and application—(1) General. This section applies to all... with the standard, including, where appropriate, (i) Workplaces where exposure to ___ results from...

  2. Safety Regulations for Ionizing Radiations. Vietnam Standard (TCVN 4397-87)

    International Nuclear Information System (INIS)

    1987-01-01

    The regulations were prepared for purpose of providing basic requirements of ionizing radiation protection and giving guide for design criteria of radiation installations in Vietnam. The allowable maximum levels for personnel categories are established. Regulated are methods for handling sealed and unsealed sources of radiation, transfer and transport of radioactive materials. Defined requirements and operating conditions that must be met. Determined are procedures and actions of decontamination. (N.H.A)

  3. Regulatory risks associated with nuclear safety legislation after Fukushima Daiichi Nuclear Accident in Japan. Focus on legal structure of the nuclear reactor regulation act

    International Nuclear Information System (INIS)

    Tanabe, Tomoyuki; Maruyama, Masahiro

    2016-01-01

    Nuclear safety regulations enforced after Fukushima Daiichi Nuclear Accident under the Nuclear Reactor Regulation Act face the following regulatory problems that involve potential risk factors for nuclear businesses; 1) 'entity based regulation' unable to cope with business cessation or bankruptcy of the entity subject of regulation, 2) potential risk of the Nuclear Regulation Authority's inappropriate involvement in nuclear industry policy beyond their duty, and 3) compliance of backfits under vague regulations. In order to alleviate them, this report, through analyzing these regulatory problems from the view point of sound development of the nuclear industry, proposes the following regulatory reforms; (1) To clarify the rule for industry policy in nuclear regulations and enable the authority, Ministry of Economy, Trade and Industry, to choose most appropriate industrial policy measure. (2) Through establishing safety goals as measures to promote continuous improvement of nuclear safety regulations, to stimulate timely adjustments of the regulations, and to introduce a legal mechanism into the nuclear regulation systems under which validity of administrative law and its application can be checked. (author)

  4. Catalogue and classification of technical safety standards, rules and regulations for nuclear power reactors and nuclear fuel cycle facilities

    International Nuclear Information System (INIS)

    Fichtner, N.; Becker, K.; Bashir, M.

    1977-01-01

    The present report is an up-dated version of the report 'Catalogue and Classification of Technical Safety Rules for Light-water Reactors and Reprocessing Plants' edited under code No EUR 5362e, August 1975. Like the first version of the report, it constitutes a catalogue and classification of standards, rules and regulations on land-based nuclear power reactors and fuel cycle facilities. The reasons for the classification system used are given and discussed

  5. Overview of Development and Deployment of Codes, Standards and Regulations Affecting Energy Storage System Safety in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Conover, David R.

    2014-08-22

    This report acquaints stakeholders and interested parties involved in the development and/or deployment of energy storage systems (ESS) with the subject of safety-related codes, standards and regulations (CSRs). It is hoped that users of this document gain a more in depth and uniform understanding of safety-related CSR development and deployment that can foster improved communications among all ESS stakeholders and the collaboration needed to realize more timely acceptance and approval of safe ESS technology through appropriate CSR.

  6. Obesity, overconsumption and self-regulation failure: The unsung role of eating appropriateness standards

    NARCIS (Netherlands)

    Ridder, de D.T.D.; Vet, de E.; Stok, F.M.; Adriaanse, M.A.; Wit, J.B.F.

    2013-01-01

    There is a tendency to blame the so-called ‘obesogenic’ environment, characterised by the abundant presence of high caloric, palatable foods, for the failure of self-regulation of eating behaviour and, consequently, the obesity epidemic. In the present article, it is argued that in addition to the

  7. A compilation of current regulations, standards and guidelines in remote afterloading brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Tortorelli, J.P.; Simion, G.P.; Kozlowski, S.D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1994-10-01

    Over a dozen government and professional organizations in the United States and Europe have issued regulations and guidance concerning quality management in the practice of remote afterloading brachytherapy. Information from the publications of these organizations was collected and collated for this report. This report provides the brachytherapy licensee access to a broad field of quality management information in a single, topically organized document.

  8. A compilation of current regulations, standards and guidelines in remote afterloading brachytherapy

    International Nuclear Information System (INIS)

    Tortorelli, J.P.; Simion, G.P.; Kozlowski, S.D.

    1994-10-01

    Over a dozen government and professional organizations in the United States and Europe have issued regulations and guidance concerning quality management in the practice of remote afterloading brachytherapy. Information from the publications of these organizations was collected and collated for this report. This report provides the brachytherapy licensee access to a broad field of quality management information in a single, topically organized document

  9. Decree 435/994 Environmental Impacts : establish a standard joint complex named Evaluation Regulations

    International Nuclear Information System (INIS)

    1994-01-01

    The Regulation of Evaluation of environmental Impact in the chapter I art.2 item 14 it establishes that It will require the previous Environmental Authorization the activities that refer to the construction of production factories and transformation of Nuclear Energy r, without damage of that settled down for the articulate 215 of the law 16.226 of October 29 1991 [es

  10. 75 FR 26025 - Regulation of Fuels and Fuel Additives: Modifications to Renewable Fuel Standard Program

    Science.gov (United States)

    2010-05-10

    ... technologies, we have created new definitions for membrane separation and raw starch hydrolysis. We also... technical errors and areas within the final RFS2 regulations that could benefit from clarification or... benefit from clarification or modification. As a result, we are making the following amendments to the...

  11. 76 FR 38843 - Regulation of Fuels and Fuel Additives: 2012 Renewable Fuel Standards

    Science.gov (United States)

    2011-07-01

    ... or renewable fuels such as ethanol and biodiesel. Potentially regulated categories include: Examples... Feedstocks To Produce 1.28 Billion Gallons Of Biodiesel 3. Production Capacity 4. Consumption Capacity 5... 5. Transportation Fuel Cost 6. Deliverability And Transport Costs Of Materials, Goods, And Products...

  12. 78 FR 35429 - Ability-to-Repay and Qualified Mortgage Standards Under the Truth in Lending Act (Regulation Z)

    Science.gov (United States)

    2013-06-12

    ... other evidence of repayment ability.\\3\\ \\2\\ Inside Mortg. Fin., The 2011 Mortgage Market Statistical..., refinancing became more difficult and delinquency rates on subprime and Alt-A products increased dramatically... peaked at 2.5 percent in late 2007.\\5\\ As the economy worsened, the rates of serious delinquency (90 or...

  13. 78 FR 6407 - Ability-to-Repay and Qualified Mortgage Standards Under the Truth in Lending Act (Regulation Z)

    Science.gov (United States)

    2013-01-30

    ..., and child support; (7) the monthly debt-to-income ratio or residual income; and (8) credit history... concerns were heightened as mortgage delinquencies and foreclosure rates increased dramatically, caused in... to repay.\\6\\ Subprime products were sold primarily to consumers with poor or no credit history...

  14. Crystalline lens - Eyes under high radiological protection. From regulation to acts. With neuro-radiologists of the Pitie-Salpetriere

    International Nuclear Information System (INIS)

    2014-01-01

    As the limit exposure of workers' crystalline lens to ionizing radiations is about to be lowered, this set of three articles proposes an overview of this specific issue. A recent study performed by the IRSN revealed that interventional cardiologists display four more crystalline lens opacification that the rest of the population, and also revealed that other incidents could affect the eyes of some operators of nuclear medicine. In interventional radiology, fingers, fists and eyes are the most exposed and have not been so well protected as the rest of the body. After dosimetry measurements, the use of protective glasses has been introduced. These protective measures could be applied in other nuclear activities. Studies are being performed on the eyes of children living in areas contaminated by the Chernobyl accident. A second article comments the various actions and initiatives aiming at limiting the dose received by the crystalline lens: preparation of a new regulation for the follow-up of exposed workers, definition of standards for dose measurement devices, risk assessments, recommendation to interventional radiologists to optimize their exposure (process, protective clothes, and so on). A last article briefly reports the implementation of a dose follow-up for interventional neuro-radiologists in a Parisian hospital

  15. National tax regulation, voluntary international standards and the GATS : Argentina – financial services

    NARCIS (Netherlands)

    Delimatsis, Panagiotis; Hoekman, Bernard

    2018-01-01

    Can a WTO Member discriminate against foreign suppliers of services located in jurisdictions that refuse to share information with a government to permit it to determine if its nationals engage in tax evasion? Does it matter if the Member uses standards developed by an international body as the

  16. 75 FR 76789 - Regulation of Fuels and Fuel Additives: 2011 Renewable Fuel Standards

    Science.gov (United States)

    2010-12-09

    ... projections as well as assessments of production capability from industry. This action establishes annual... American Industry Classification System (NAICS). \\2\\ Standard Industrial Classification (SIC) system code... facility has a maximum production capacity of 250,000 gallons of ethanol per year and uses an enzymatic...

  17. Trends in food safety standards and regulation implications for developing countries

    OpenAIRE

    Caswell, Julie A.

    2003-01-01

    "Food safety is affected by the decisions of producers, processors, distributors, food service operators, and consumers, as well as by government regulations. In developed countries, the demand for higher levels of food safety has led to the implementation of regulatory programs that address more types of safety-related attributes (such as bovine spongiform encephalopathy (BSE), microbial pathogens, environmental contaminants, and animal drug and pesticide residues) and impose stricter standa...

  18. 76 FR 72878 - Financial Crimes Enforcement Network; Amendment to the Bank Secrecy Act Regulations-Imposition of...

    Science.gov (United States)

    2011-11-28

    ... Iran as a Jurisdiction of Primary Money Laundering Concern AGENCY: Financial Crimes Enforcement Network... Republic of Iran (``Iran'') is a jurisdiction of primary money laundering concern pursuant to 31 U.S.C... Act amends the anti- money laundering provisions of the Bank Secrecy Act (``BSA''), codified at 12 U.S...

  19. Survey of legal aspects, regulations, standards and guidelines applicable to radioactive waste management of the Brazilian Multipurpose Reactor - RMB

    International Nuclear Information System (INIS)

    Salvetti, T.C.; Marumo, J.T.

    2017-01-01

    In Brazil, the Brazilian Nuclear Energy Commission (CNEN) and Brazilian Institute of Environment and Renewable Natural Resources (IBAMA) are the agencies responsible for the execution, regulation and control of nuclear and environmental policies, respectively. Such regulatory activities are very comprehensive (IBAMA) or too specific (CNEN), revealing other aspects that would, also, need to be observed so that the management could be carried out efficiently (quality) and effectively (safety), including the three governmental administrative levels: Federal, State and Municipal. In addition to laws, regulations, decrees and resolutions, there are also national and international standards and guides that provide guidelines for structuring the current management and the use of best regulatory practices. The Brazilian Multipurpose Reactor Enterprise (RMB) is a CNEN project, complying with a Multi-Year Plan of the Brazilian Ministry of Planning, Development and Management (MPDG). The Enterprise is being developed under the responsibility of the Directorate of Research and Development - DPD of CNEN and will have a facility for treatment and initial temporary storage of the radioactive waste generated by the operation of the research reactor and the activities carried out in the associated laboratories. The RMB will be built in the city of IPERÓ, located in the state of São Paulo, near ARAMAR Experimental Center of the Brazilian Navy. This work aims to present the research results regarding the various aspects that regulate, legislate and standardize the practices proposed to the Radioactive Waste Management of the RMB project. (author)

  20. Survey of legal aspects, regulations, standards and guidelines applicable to radioactive waste management of the Brazilian Multipurpose Reactor - RMB

    Energy Technology Data Exchange (ETDEWEB)

    Salvetti, T.C.; Marumo, J.T., E-mail: salvetti@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP), São Paulo, SP (Brazil)

    2017-07-01

    In Brazil, the Brazilian Nuclear Energy Commission (CNEN) and Brazilian Institute of Environment and Renewable Natural Resources (IBAMA) are the agencies responsible for the execution, regulation and control of nuclear and environmental policies, respectively. Such regulatory activities are very comprehensive (IBAMA) or too specific (CNEN), revealing other aspects that would, also, need to be observed so that the management could be carried out efficiently (quality) and effectively (safety), including the three governmental administrative levels: Federal, State and Municipal. In addition to laws, regulations, decrees and resolutions, there are also national and international standards and guides that provide guidelines for structuring the current management and the use of best regulatory practices. The Brazilian Multipurpose Reactor Enterprise (RMB) is a CNEN project, complying with a Multi-Year Plan of the Brazilian Ministry of Planning, Development and Management (MPDG). The Enterprise is being developed under the responsibility of the Directorate of Research and Development - DPD of CNEN and will have a facility for treatment and initial temporary storage of the radioactive waste generated by the operation of the research reactor and the activities carried out in the associated laboratories. The RMB will be built in the city of IPERÓ, located in the state of São Paulo, near ARAMAR Experimental Center of the Brazilian Navy. This work aims to present the research results regarding the various aspects that regulate, legislate and standardize the practices proposed to the Radioactive Waste Management of the RMB project. (author)

  1. Development and validation of new spectrophotometric ratio H-point standard addition method and application to gastrointestinal acting drugs mixtures

    Science.gov (United States)

    Yehia, Ali M.

    2013-05-01

    New, simple, specific, accurate and precise spectrophotometric technique utilizing ratio spectra is developed for simultaneous determination of two different binary mixtures. The developed ratio H-point standard addition method (RHPSAM) was managed successfully to resolve the spectral overlap in itopride hydrochloride (ITO) and pantoprazole sodium (PAN) binary mixture, as well as, mosapride citrate (MOS) and PAN binary mixture. The theoretical background and advantages of the newly proposed method are presented. The calibration curves are linear over the concentration range of 5-60 μg/mL, 5-40 μg/mL and 4-24 μg/mL for ITO, MOS and PAN, respectively. Specificity of the method was investigated and relative standard deviations were less than 1.5. The accuracy, precision and repeatability were also investigated for the proposed method according to ICH guidelines.

  2. International labor standards and the political economy of child labor regulation

    OpenAIRE

    Doepke, Matthias; Zilibotti, Fabrizio

    2008-01-01

    Child labor is a persistent phenomenon in many developing countries. In recent years, support has been growing among rich-country governments and consumer groups for the use of trade policies, such as product boycotts and the imposition of international labor standards, to reduce child labor in poor countries. In this paper, we discuss research on the long-run implications of such policies. In particular, we demonstrate that such measures may have the unintended side effect of lowering domest...

  3. The method of using current regulations and standards in designing management and technologies of construction

    Directory of Open Access Journals (Sweden)

    Sinenko Sergey

    2017-01-01

    Full Text Available Economic efficiency of using funds in construction of buildings and structures begins from an effective, proper design, which is based on modern, cutting-edge, advanced equipment, streamlined organization and process solutions of construction operations. In the light of this it is considered application of “Self-Organization and Technology of Building” multifunctional software package capable of solving various engineering tasks on designing management of construction operations in accordance with the applicable rules and regulations in view of using software for automatic generation of workflow. Implementing this software in the construction management processes may help to solve management tasks at the construction site.

  4. The use of innovation action research approach in the preparation of a regulation on costing standard 

    Directory of Open Access Journals (Sweden)

    Monika Raulinajtys-Grzybek

    2016-04-01

    Full Text Available The article analyzes the applicability of the innovation action research method for activities related to the preparation of a concept of a costing standard for healthcare providers which is subject to legal regula- tion. This legislation regulates the way providers, reporting data for the purpose of the regulated pricing of health services, identify and calculate costs. A 39-month long research project was carried out in ac- cordance with the innovation action research approach, which resulted in the creation of a novel concept of a costing model. The generation of new knowledge occurred as a result of a collaboration between researchers and practitioners, which is a basic assumption of action research. The consecutive steps of the research have been characterized in order to present the influence of the research method on the devel- opment and modification of the initial concept.

  5. The political economy of regulation: Investigation of the relationship between design and performance standards in surface coal mining

    International Nuclear Information System (INIS)

    Walker, K.R.

    1991-01-01

    Research concerning political and economic regulatory policy was conducted on 15 randomly selected surface coal mines in Tennessee. Data on violations were collected over a 6-year period from 1979 through 1984. The primary purpose of this study was to investigate the approaches of the Carter and Reagan administrations concerning the implementation of design and performance regulations of Public Law 95-87. The study concluded that: (1) A change in political administration affects regulatory policy concerning enforcement practices. (2) Regulatory policy is altered in the direction of economic activity believed by an administration to be desirable to society and its constituents. (3) Elaborate rule making activity constrains market activity. (4) The coupling of design and performance standards should be retained. No difference was found in the number of violations for design and associated performance standards. Findings support the theory that it is the administration that affects change in regulatory policy, and not the regulatory construct for compliance with a mandate

  6. Non-Standard Workers: The South African Context, International Law and Regulation by The European Union

    Directory of Open Access Journals (Sweden)

    ES Fourie

    2008-12-01

    Full Text Available The current labour market has many forms of employment relations that differ from full-time employment. "Atypical," "non-standard," or even "marginal" are terms used to describe these new workers and include, amongst others, part-time work, contract work, self-employment, temporary, fixed-term, seasonal, casual, piece-rate work, employees supplied by employment agencies, home workers and those employed in the informal economy. These workers are often paid for results rather than time. Their vulnerability is linked in many instances to the absence of an employment relationship or the existence of a flimsy one. Most of these workers are unskilled or work in sectors with limited trade union organisation and limited coverage by collective bargaining, leaving them vulnerable to exploitation. They should, in theory, have the protection of current South African labour legislation, but in practice the unusual circumstances of their employment render the enforcement of their rights problematic. The majority of non-standard workers in South Africa are those previously disadvantaged by the apartheid regime, compromising women and unskilled black workers. The exclusion of these workers from labour legislation can be seen as discrimination, which is prohibited by almost all labour legislation in South Africa. This contribution illustrates how the concept of indirect discrimination can be an important tool used to provide labour protection to these workers. The purpose of this article is to explore the scope of the extension of labour rights to non-standard workers in the context of South African labour laws and the international framework.

  7. Ethical standards and regulations principles of professional conduct in the field of mediation

    Directory of Open Access Journals (Sweden)

    Yulia I. Melnychuk

    2016-01-01

    Full Text Available An origin of conflicts, during life of man, is the inevitable phenomenon. A subject for a conflict results in the origin of conflict situation, which contains the negative colouring the display of which can be offence. Mediaciya appears the alternative method of permission of conflict, which is directed on zalagodzhennya and decision of conflicts by the direct socializing with an offender and suffering. A collaboration as a result of realization of which reasons of divergences and aspiration of resisting sides of search of vzaemopriynyatnikh ways of decision of situation turn out appears the base of process of mediacii. In this process the third participant is a neurohumor, the purpose of activity of which is adjusting and communicative process control. Institualizaciya of codes of conduct, which are added the certain types of moral mutual relations between people is optimum for realization of professional activity. Socialphilosophical interpretation of cultural, humanism principles of restoration process is fixed in the ethics standards of mediacii. Ethics norms are key in achievement of the real perfection, that is why there is a clear requirement in the ethics estimation of practice of neurohumor for the maintainance of moral, legal norms upgrading functioning. Professional practice of neurohumor is based on an awareness them of ethics aspects and social payment in prevention of recidivism, observance of ethics rules and standards, proper European legislation, national traditions.

  8. Cooperative development of nuclear safety regulations, guides and standards based on NUSS

    International Nuclear Information System (INIS)

    Pachner, J.; Boyd, F.C.; Yaremy, E.M.

    1984-10-01

    In 1983, the Atomic Energy Control Board and Atomic Energy of Canada Limited conducted a study of a possible joint program involving Canada, a nuclear power plant importing Member State and the IAEA for the development of the national nuclear safety regulations and guides based on NUSS documents. During the study, a work plan with manpower estimates for the development of design was prepared as an investigatory exercise. The work plan suggests that a successful NUSS implementation in developing Member States will require availability of significant resources at the start of the program. The study showed that such a joint program could provide an effective mechanism for transfer of nuclear safety know-how to the developing Member States through NUSS implementation

  9. Study on Laws, Regulations and Standards on Energy Efficiency, Energy Conserving and Emission Reduction of Industrial Boilers in EU

    Science.gov (United States)

    Liu, Ren; Zhao, Yuejin; Chen, Haihong; Liang, Xiuying; Yang, Ming

    2017-12-01

    Industrial boilers are widely applied in such fields as factory power, building heating, and people’s lives; China is the world’s largest producer and user of industrial boilers, with very high annual energy consumption; clear requirements have been put forward by China on the energy efficiency since the “11th Five-year Plan” with the hope to save energy and reduce emission by means of energy efficiency standards and regulations on the supervision and control of various special equipment. So far, the energy efficiency of industrial boilers in China has been improved significantly but there is still a gap with the EU states. This paper analyzes the policies of energy efficiency, implementation models and methods of supervision and implementation at the EU level from laws, regulations, directives as well as standards; the paper also puts forward suggestions of energy conserving and emission reduction on the improvement of energy conserving capacity of industrial boilers in China through studying the legislations and measures of the developed countries in energy conserving of boilers.

  10. Regulations, guidelines, standards, and policies pertaining to decontamination and decommissioning activities: A literature review. Informal report, Revision 1

    International Nuclear Information System (INIS)

    Cowgill, M.G.

    1994-09-01

    A literature review of the existing rules, regulations, and guidelines pertaining to the decontamination and decommissioning of nuclear facilities has been updated. Included in the survey are US Government documents, national (industrial) standards, international standards and guidelines, and the regulations issued by various national governments, such as the United Kingdom, Canada, and Germany. The Department of Energy (DOE) complex contains within it almost 1,000 nuclear facilities which will require decommissioning in the coming years. This action will entail activities in many different areas, one of which will involve the development of the basic safety principles to be applied to the process as a whole. These principles will be used to guide personnel in the development of safety assessment procedures for decontamination and decommissioning (D and D) activities and in conducting safety assessments of such activities at the facilities themselves. The present report represents an updating of the original report. It retains all the information that appeared in the original report with the new material integrated into the applicable sections. Future revisions will be made as additional information becomes available

  11. Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I

    International Nuclear Information System (INIS)

    Seiki, Motoharu; Inoue, Junichiro; Hidaka, Makoto; Yoshida, Mitsuaki

    1988-01-01

    The pX sequence of human T-cell leukemia virus type I codes for two nuclear proteins, p40 tax and p27 rex and a cytoplasmic protein, p21 X-III . p40 tax activates transcription from the long terminal repeat (LTR), whereas p27 rex modulates posttranscriptional processing to accumulate gag and env mRNAs that retain intron sequences. In this paper, the authors identify two cis-acting sequence elements needed for regulation by p27 rex : a 5' splice signal and a specific sequence in the 3' LTR. These two sequence elements are sufficient for regulation by p27 rex ; expression of a cellular gene (metallothionein I) became sensitive to rex regulation when the LTR was inserted at the 3' end of this gene. The requirement for these two elements suggests and unusual regulatory mechanism of RNA processing in the nucleus

  12. The French Space Operation Act: Scope and Main Features. Introduction to the Technical Regulation Considerations about the Implementation in the Launcher Field

    Science.gov (United States)

    Cahuzac, Francois

    2010-09-01

    This publication provides a presentation of the new French Space Operation Act(hereafter FSOA). The main objectives of FSOA are to institute a clarified legal regime for launch operations. The technical regulation associated to the act is set forth, in particular for the safety of persons and property, the protection of public health and the environment. First, we give an overview of the institutional and legal framework implemented in accordance with the act. The general purpose of this French Space Operation Act(hereafter FSOA) is to set up a coherent national regime of authorization and control of Space operations under the French jurisdiction or for which the French Government bears international liability either under UN Treaties principles(namely the 1967 Outer Space Treaty, the 1972 Liability Convention and the 1976 Registration Convention) or in accordance with its European commitments with the ESA organization and its Members States. For a given space operation, the operator must show that systems and procedures that he intends to implement are compliant with the technical regulation. The regime of authorization leads to a request of authorization for each launch operation. Thus, licences concerning operator management organization or a given space system can be obtained. These licences help to simplify the authorization file required for a given space operation. The technical regulation is presented in another article, and will be issued in 2010 by the French Minister in charge of space activities. A brief description of the organization associated to the implementation of the authorization regime in the launcher field is presented.

  13. The role of gut microbiota in the regulation of standard metabolic rate in female Periplaneta americana

    Directory of Open Access Journals (Sweden)

    Paul A. Ayayee

    2018-05-01

    Full Text Available Insect gut microbiota contribute significantly to host nutritional ecology. Disrupting insect gut microbial assemblages impacts nutrient provisioning functions, and can potentially affect host standard metabolic rate (SMR, a measure of host energy balance. In this study, we evaluated the effect of disrupting gut microbial assemblages on the SMR of female Periplaneta americana cockroaches fed dog food (DF, high protein/carbohydrate (p/c ratio, and cellulose-amended dog food (CADF, 30% dog food, 70% cellulose, low p/c ratio diets, supplemented with none, low, or high antibiotic doses. Bacterial loads decreased significantly between diet types (P = 0.04 and across antibiotic doses (P = 0.04. There was a significant diet type x antibiotic dose interaction on SMR of females on both diets (P = 0.05 by the end of the seven-day experimental period. In CADF-fed females, SMR decreased linearly with decreasing bacterial load. However, SMR of DF-fed females on the low dose was significantly higher than those in the control and high dose groups. This is interpreted as a diet-dependent response by low dose DF-fed females to the loss of nutritional services provided by gut bacteria. Severe reductions in bacterial load at high doses reduced SMR of females on both diet types. This study provides insights into the potential role of gut bacteria as modulators of host energy expenditure under varying dietary conditions.

  14. A Model of Yeast Cell-Cycle Regulation Based on a Standard Component Modeling Strategy for Protein Regulatory Networks.

    Directory of Open Access Journals (Sweden)

    Teeraphan Laomettachit

    Full Text Available To understand the molecular mechanisms that regulate cell cycle progression in eukaryotes, a variety of mathematical modeling approaches have been employed, ranging from Boolean networks and differential equations to stochastic simulations. Each approach has its own characteristic strengths and weaknesses. In this paper, we propose a "standard component" modeling strategy that combines advantageous features of Boolean networks, differential equations and stochastic simulations in a framework that acknowledges the typical sorts of reactions found in protein regulatory networks. Applying this strategy to a comprehensive mechanism of the budding yeast cell cycle, we illustrate the potential value of standard component modeling. The deterministic version of our model reproduces the phenotypic properties of wild-type cells and of 125 mutant strains. The stochastic version of our model reproduces the cell-to-cell variability of wild-type cells and the partial viability of the CLB2-dbΔ clb5Δ mutant strain. Our simulations show that mathematical modeling with "standard components" can capture in quantitative detail many essential properties of cell cycle control in budding yeast.

  15. NEURO-SYSTEM OF AIMING AND STABILIZING WITH A REGULATOR ON THE BASIS OF STANDARD MODEL MODEL REFERENCE CONTROLLER

    Directory of Open Access Journals (Sweden)

    B.I. Kuznetsov

    2015-08-01

    Full Text Available The aim of this work is the synthesis of neural network aiming and stabilization system for the special equipment of moving objects with neuro-controller on the basis of standard model and performance comparison of the neural network system with the neural network predictive control. Build a block diagram of the neural network aiming and stabilization system, based on the subject control principle with PD-regulator in the position loop and with neuro-controller on the basis of standard model in the in the velocity loop. The neuro-controller on the basis of standard model Model Reference Controller is synthesized in the MATLAB Neural Network Toolbox and system simulation is performed. The studies show that the transient state variables of the system are oscillatory. Therefore, the neuro-controller with the prediction NN Predictive Controller should be used for aiming and stabilizing system to provide high dynamic characteristics achieved at the cost of higher complexity and computational cost.

  16. 77 FR 33638 - Amendment to the Bank Secrecy Act Regulations-Exemption From the Requirement To Report...

    Science.gov (United States)

    2012-06-07

    ... effectiveness of its anti-money laundering and counter-terrorist financing policies. \\1\\ These customers are... enforcement purposes. \\6\\ See section 402 of the Money Laundering Suppression Act of 1994 (the ``Money...\\ 31 U.S.C. 5311. \\4\\ Treasury Order 180-01 (Sept. 26, 2002). \\5\\ 31 U.S.C. 5318(h)(2). The Money...

  17. 78 FR 23171 - Amendments to the 2013 Escrows Final Rule Under the Truth in Lending Act (Regulation Z)

    Science.gov (United States)

    2013-04-18

    ... provisions take effect in January 2014. DATES: Comments must be received on or before May 3, 2013. ADDRESSES... Disclosure Act (HMDA) data (for ``underserved'') and to provide illustrations of the rule to facilitate... this reason, the 2013 Escrows Final Rule removed the regulatory text providing these protections solely...

  18. 78 FR 60381 - Amendments to the 2013 Mortgage Rules Under the Equal Credit Opportunity Act (Regulation B), Real...

    Science.gov (United States)

    2013-10-01

    ... policies and procedures for depository institutions) and the associated commentary. The Bureau believes... sparked the most severe U.S. recession since the Great Depression, Congress passed the Dodd-Frank Act... banking institutions stated its appreciation for the Bureau's efforts to facilitate compliance and...

  19. 78 FR 62993 - Amendments to the 2013 Mortgage Rules Under the Real Estate Settlement Procedures Act (Regulation...

    Science.gov (United States)

    2013-10-23

    .... recession since the Great Depression, Congress passed the Dodd-Frank Act, which was signed into law [[Page... institutions lock down their computer systems late in the calendar year due to high holiday processing volume and the need to generate year-end reports, institutions have relatively little time to institute...

  20. 78 FR 30739 - Amendments to the 2013 Escrows Final Rule under the Truth in Lending Act (Regulation Z)

    Science.gov (United States)

    2013-05-23

    ... severe U.S. recession since the Great Depression, Congress passed the Dodd-Frank Act, which was signed... depository institutions and credit unions with $10 billion or less in total assets as described in section... small differential impact on depository institutions and credit unions with $10 billion or less in total...

  1. TetR-dependent gene regulation in intracellular Listeria monocytogenes demonstrates the spatiotemporal surface distribution of ActA.

    Science.gov (United States)

    Schmitter, Sibylle; Fieseler, Lars; Klumpp, Jochen; Bertram, Ralph; Loessner, Martin J

    2017-08-01

    To enable specific and tightly controlled gene expression both in vitro and during the intracellular lifecycle of the pathogen Listeria monocytogenes, a TetR-dependent genetic induction system was developed. Highest concentration of cytoplasmic TetR and best repression of tetO-controlled genes was obtained by tetR expression from the synthetic promoter Pt 17 . Anhydrotetracycline (ATc) as inducer permitted concentration-dependent, fine-tuned expression of genes under control of the tetO operator and a suitable promoter. The actin-polymerizing ActA protein represents a major virulence factor of L. monocytogenes, required for actin-based motility and cell-to-cell spread in infected host cells. To be able to observe its spatial and temporal distribution on intracellular L. monocytogenes cells, conditional mutants featuring actA placed under TetR control were used to infect PtK2 epithelial cells. Following induction at different time intervals, the subsequent recruitment of actin by L. monocytogenes could be monitored. We found that cells displayed functional ActA after approximately 15 min, while formation of polarized actin tail was complete after 90-120 min. At this point, intracellular motility of the induced mutants was indistinguishable from wild-type bacteria. Interestingly, de novo ActA synthesis in intracellular Listeria also demonstrated the temporal, asymmetric redistribution of the membrane-anchored proteins from the lateral walls toward the cell poles. © 2017 John Wiley & Sons Ltd.

  2. Co-regulation in EU personal data protection : The case of technical standards and the privacy by design standardisation ‘mandate’

    NARCIS (Netherlands)

    Kamara, Irene

    The recently adopted General Data Protection Regulation (GDPR), a technology-neutral law, endorses self-regulatory instruments, such as certification and technical standards. Even before the adoption of the General Data Protection Regulation, standardisation activity in the field of privacy

  3. 7 CFR 54.1027 - Application of other regulations to appeal service.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT..., Processing, and Packaging of Livestock and Poultry Products § 54.1027 Application of other regulations to...

  4. 76 FR 15856 - Standards of Conduct

    Science.gov (United States)

    2011-03-22

    ... Management and Budget under 44 U.S.C. chapter 35. F. Small Business Regulatory Enforcement Fairness Act This... codified GSA's supplemental standards of ethical conduct in the new 5 CFR part 6701. At that time, GSA... provided a number of cross- references to the new Government-wide standards of ethical conduct regulations...

  5. 7 CFR 59.400 - OMB control number assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) LIVESTOCK MANDATORY REPORTING OMB Control Number § 59.400 OMB control number...

  6. The Commitment decision according to paragraph 29 EnWG - a standardizing regulation under the supervision of the courts; Die Festlegungsentscheidung nach paragraph 29 EnWG - normierende Regulierung unter den Augen der Gerichte

    Energy Technology Data Exchange (ETDEWEB)

    Attendorn, Thorsten [Bezirksregierung Arnsberg (Germany)

    2009-03-15

    With the commitment decision according to paragraph 29 Energy Economy Act, the regulation authority has an effective instrument, which enables a one-sided determination of the entrance conditions and entrance methods as well as tariffs. This is an application of the standardizing regulation. The desired result is not caused ex post, but ex-ante. This is due to a uniform decision instead of a multiplicity of abuse decisions. The first commitment decisions passed the court instances. In the meantime, there are several decisions of the higher regional court and the Federal High Court. That gives cause to a stock-taking. The author of the contribution under consideration reports on this stock-tacking.

  7. Effect of two additional interventions, test and reflection, added to standard cardiopulmonary resuscitation training on seventh grade students' practical skills and willingness to act: a cluster randomised trial.

    Science.gov (United States)

    Nord, Anette; Hult, Håkan; Kreitz-Sandberg, Susanne; Herlitz, Johan; Svensson, Leif; Nilsson, Lennart

    2017-06-23

    The aim of this research is to investigate if two additional interventions, test and reflection, after standard cardiopulmonary resuscitation (CPR) training facilitate learning by comparing 13-year-old students' practical skills and willingness to act. Seventh grade students in council schools of two municipalities in south-east Sweden. School classes were randomised to CPR training only (O), CPR training with a practical test including feedback (T) or CPR training with reflection and a practical test including feedback (RT). Measures of practical skills and willingness to act in a potential life-threatening situation were studied directly after training and at 6 months using a digital reporting system and a survey. A modified Cardiff test was used to register the practical skills, where scores in each of 12 items resulted in a total score of 12-48 points. The study was conducted in accordance with current European Resuscitation Council guidelines during December 2013 to October 2014. 29 classes for a total of 587 seventh grade students were included in the study. The total score of the modified Cardiff test at 6 months was the primary outcome. Secondary outcomes were the total score directly after training, the 12 individual items of the modified Cardiff test and willingness to act. At 6 months, the T and O groups scored 32 (3.9) and 30 (4.0) points, respectively (ptraining improved the students' acquisition of practical CPR skills. Reflection did not increase further CPR skills. At 6-month follow-up, no intervention effect was found regarding willingness to make a life-saving effort. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  8. Energy Building Regulations: The Effect of the Federal Performance Standards on Building Code Administration and the Conservation of Energy in New Buildings.

    Science.gov (United States)

    Kopper, William D.

    1980-01-01

    Explores the changes in the administration and enforcement of building regulations that will be engendered by the proposed federal energy building standards. Also evaluates the effectiveness of those standards in meeting congressional intent. Available from U.C. Davis Law Review, School of Law, Martin Luther King Jr. Hall, University of…

  9. "Plain packaging" regulations for tobacco products: the impact of standardizing the color and design of cigarette packs.

    Science.gov (United States)

    Hammond, David

    2010-01-01

    Tobacco packaging and labeling policies have emerged as prominent and cost-effective tobacco control measures. Although packaging policies have primarily focused on health warnings, there is growing recognition of the importance of packaging as a marketing tool for the tobacco industry. The current paper reviews evidence on the potential impact of standardizing the color and design of tobacco packages -so called "plain" packaging. The evidence indicates three primary benefits of plain packaging: increasing the effectiveness of health warnings, reducing false health beliefs about cigarettes, and reducing brand appeal especially among youth and young adults. Overall, the research to date suggests that "plain" packaging regulations would be an effective tobacco control measure, particularly in jurisdictions with comprehensive restrictions on other forms of marketing.

  10. Trust, but Verify: Standard Setting That Honors and Validates Professional Teacher Judgment. Subtitle: A Tenuous Titanic Tale of Testy Testing and Titillating Touchstones (A Screen Play with an Unknown Number of Acts).

    Science.gov (United States)

    Matter, M. Kevin

    The Cherry Creek School district (Englewood, Colorado) is a growing district of 37,000 students in the Denver area. The 1988 Colorado State School Finance Act required district-set proficiencies (standards), and forced agreement on a set of values for student knowledge and skills. State-adopted standards added additional requirements for the…

  11. Regulations for RA reactor operation

    International Nuclear Information System (INIS)

    1980-09-01

    Regulations for RA reactor operation are written in accordance with the legal regulations defined by the Law about radiation protection and related legal acts, as well as technical standards according to the IAEA recommendations. The contents of this book include: fundamental data about the reactor; legal regulations for reactor operation; organizational scheme for reactor operation; general and detailed instructions for operation, behaviour in the reactor building, performing experiments; operating rules for operation under steady state and accidental conditions [sr

  12. The Causal Effect of Student Mobility on Standardized Test Performance: A Case Study with Possible Implications for Accountability Mandates within the Elementary and Secondary Education Act

    Directory of Open Access Journals (Sweden)

    Arielle Selya

    2016-07-01

    Full Text Available This paper presents a limited case study examining the causal inference of student mobility on standardized test performance, within one middle-class high school in suburban Connecticut. Administrative data were used from a district public high school enrolling 319 10th graders in 2010. Propensity score methods were used to estimate the causal effect of student mobility on Math, Science, Reading, and Writing portions of the Connecticut Academic Performance Test (CAPT, after matching mobile vs. stable students on gender, race/ethnicity, eligibility for free/reduced lunches, and special education status. Analyses showed that mobility was associated with lower performance in the CAPT Writing exam. Follow-up analyses revealed that this trend was only significant among those who were ineligible for free/reduced lunches, but not among eligible students. Additionally, mobile students who were ineligible for free/reduced lunches had lower performance in the CAPT Science exam according to some analyses. Large numbers of students transferring into a school district may adversely affect standardized test performance. This is especially relevant for policies that affect student mobility in schools, given the accountability measures in the No Child Left Behind that are currently being re-considered in the recent Every Student Succeeds Act.

  13. The Causal Effect of Student Mobility on Standardized Test Performance: A Case Study with Possible Implications for Accountability Mandates within the Elementary and Secondary Education Act.

    Science.gov (United States)

    Selya, Arielle S; Engel-Rebitzer, Eden; Dierker, Lisa; Stephen, Eric; Rose, Jennifer; Coffman, Donna L; Otis, Mindy

    2016-01-01

    This paper presents a limited case study examining the causal inference of student mobility on standardized test performance, within one middle-class high school in suburban Connecticut. Administrative data were used from a district public high school enrolling 319 10th graders in 2010. Propensity score methods were used to estimate the causal effect of student mobility on Math, Science, Reading, and Writing portions of the Connecticut Academic Performance Test (CAPT), after matching mobile vs. stable students on gender, race/ethnicity, eligibility for free/reduced lunches, and special education status. Analyses showed that mobility was associated with lower performance in the CAPT Writing exam. Follow-up analyses revealed that this trend was only significant among those who were ineligible for free/reduced lunches, but not among eligible students. Additionally, mobile students who were ineligible for free/reduced lunches had lower performance in the CAPT Science exam according to some analyses. Large numbers of students transferring into a school district may adversely affect standardized test performance. This is especially relevant for policies that affect student mobility in schools, given the accountability measures in the No Child Left Behind that are currently being re-considered in the recent Every Student Succeeds Act.

  14. Myostatin acts as an autocrine/paracrine negative regulator in myoblast differentiation from human induced pluripotent stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Fei; Kishida, Tsunao; Ejima, Akika [Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto (Japan); Gojo, Satoshi [Department of Cardiac Support, Kyoto Prefectural University of Medicine, Kyoto (Japan); Mazda, Osam, E-mail: mazda@koto.kpu-m.ac.jp [Department of Immunology, Kyoto Prefectural University of Medicine, Kyoto (Japan)

    2013-02-08

    Highlights: ► iPS-derived cells express myostatin and its receptor upon myoblast differentiation. ► Myostatin inhibits myoblast differentiation by inhibiting MyoD and Myo5a induction. ► Silencing of myostatin promotes differentiation of human iPS cells into myoblasts. -- Abstract: Myostatin, also known as growth differentiation factor (GDF-8), regulates proliferation of muscle satellite cells, and suppresses differentiation of myoblasts into myotubes via down-regulation of key myogenic differentiation factors including MyoD. Recent advances in stem cell biology have enabled generation of myoblasts from pluripotent stem cells, but it remains to be clarified whether myostatin is also involved in regulation of artificial differentiation of myoblasts from pluripotent stem cells. Here we show that the human induced pluripotent stem (iPS) cell-derived cells that were induced to differentiate into myoblasts expressed myostatin and its receptor during the differentiation. An addition of recombinant human myostatin (rhMyostatin) suppressed induction of MyoD and Myo5a, resulting in significant suppression of myoblast differentiation. The rhMyostatin treatment also inhibited proliferation of the cells at a later phase of differentiation. RNAi-mediated silencing of myostatin promoted differentiation of human iPS-derived embryoid body (EB) cells into myoblasts. These results strongly suggest that myostatin plays an important role in regulation of myoblast differentiation from iPS cells of human origin. The present findings also have significant implications for potential regenerative medicine for muscular diseases.

  15. Myostatin acts as an autocrine/paracrine negative regulator in myoblast differentiation from human induced pluripotent stem cells

    International Nuclear Information System (INIS)

    Gao, Fei; Kishida, Tsunao; Ejima, Akika; Gojo, Satoshi; Mazda, Osam

    2013-01-01

    Highlights: ► iPS-derived cells express myostatin and its receptor upon myoblast differentiation. ► Myostatin inhibits myoblast differentiation by inhibiting MyoD and Myo5a induction. ► Silencing of myostatin promotes differentiation of human iPS cells into myoblasts. -- Abstract: Myostatin, also known as growth differentiation factor (GDF-8), regulates proliferation of muscle satellite cells, and suppresses differentiation of myoblasts into myotubes via down-regulation of key myogenic differentiation factors including MyoD. Recent advances in stem cell biology have enabled generation of myoblasts from pluripotent stem cells, but it remains to be clarified whether myostatin is also involved in regulation of artificial differentiation of myoblasts from pluripotent stem cells. Here we show that the human induced pluripotent stem (iPS) cell-derived cells that were induced to differentiate into myoblasts expressed myostatin and its receptor during the differentiation. An addition of recombinant human myostatin (rhMyostatin) suppressed induction of MyoD and Myo5a, resulting in significant suppression of myoblast differentiation. The rhMyostatin treatment also inhibited proliferation of the cells at a later phase of differentiation. RNAi-mediated silencing of myostatin promoted differentiation of human iPS-derived embryoid body (EB) cells into myoblasts. These results strongly suggest that myostatin plays an important role in regulation of myoblast differentiation from iPS cells of human origin. The present findings also have significant implications for potential regenerative medicine for muscular diseases

  16. Myostatin acts as an autocrine/paracrine negative regulator in myoblast differentiation from human induced pluripotent stem cells.

    Science.gov (United States)

    Gao, Fei; Kishida, Tsunao; Ejima, Akika; Gojo, Satoshi; Mazda, Osam

    2013-02-08

    Myostatin, also known as growth differentiation factor (GDF-8), regulates proliferation of muscle satellite cells, and suppresses differentiation of myoblasts into myotubes via down-regulation of key myogenic differentiation factors including MyoD. Recent advances in stem cell biology have enabled generation of myoblasts from pluripotent stem cells, but it remains to be clarified whether myostatin is also involved in regulation of artificial differentiation of myoblasts from pluripotent stem cells. Here we show that the human induced pluripotent stem (iPS) cell-derived cells that were induced to differentiate into myoblasts expressed myostatin and its receptor during the differentiation. An addition of recombinant human myostatin (rhMyostatin) suppressed induction of MyoD and Myo5a, resulting in significant suppression of myoblast differentiation. The rhMyostatin treatment also inhibited proliferation of the cells at a later phase of differentiation. RNAi-mediated silencing of myostatin promoted differentiation of human iPS-derived embryoid body (EB) cells into myoblasts. These results strongly suggest that myostatin plays an important role in regulation of myoblast differentiation from iPS cells of human origin. The present findings also have significant implications for potential regenerative medicine for muscular diseases. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. 18 CFR 40.3 - Availability of Reliability Standards.

    Science.gov (United States)

    2010-04-01

    ... Reliability Standards. 40.3 Section 40.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT MANDATORY RELIABILITY STANDARDS FOR THE BULK-POWER SYSTEM § 40.3 Availability of Reliability Standards. The Electric Reliability...

  18. Regulation of accounting standards

    OpenAIRE

    Μαυρόγιαννη, Λεμονιά

    2014-01-01

    Η παρούσα διπλωματική εργασία πραγματεύεται το ρυθμιστικό ή κανονιστικό πλαίσιο των διαδικασιών που σχετίζονται με την παραγωγή λογιστικών πληροφοριών. Σκοπός της παρούσας εργασίας είναι να αναλύσει τις μορφές ρύθμισης σε επίπεδο Χρηματοοικονομικής Πληροφόρησης σε διεθνές πλαίσιο. Η μεθοδολογία που ακολουθήθηκε για την διεξαγωγή της έρευνας αυτής βασίστηκε στην ανάλυση της διεθνούς βιβλιογραφίας. Μερικά από τα κυριότερα συμπεράσματα που προέκυψαν από την έρευνα είναι ότι δίνεται ρυθμιστική κα...

  19. Title I--improving the academic achievement of the disadvantaged; Individuals with Disabilities Education Act (IDEA)--assistance to states for the education of children with disabilities. Final regulations.

    Science.gov (United States)

    2007-04-09

    The Secretary amends the regulations governing programs administered under Title I of the Elementary and Secondary Education Act of 1965 (ESEA), as amended by the No Child Left Behind Act of 2001 (NCLB) (referred to in these regulations as the Title I program) and the regulations governing programs under Part B of the Individuals with Disabilities Education Act (IDEA) (referred to in these regulations as the IDEA program). These regulations provide States with additional flexibility regarding State, local educational agency (LEA), and school accountability for the achievement of a small group of students with disabilities whose progress is such that, even after receiving appropriate instruction, including special education and related services designed to address the students' individual needs, the students' individualized education program (IEP) teams (IEP Teams) are reasonably certain that the students will not achieve grade-level proficiency within the year covered by the students' IEPs.

  20. Addressing environmental contamination through market regulations

    African Journals Online (AJOL)

    Contrary to the prevailing view that the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) law, which amended the US Toxic Substances Control Act (TSCA), is the 'gold standard' for chemical regulation, the central premise of this article is that the Frank R. Lautenberg Chemical Safety Act for the ...

  1. SN-38 Acts as a Radiosensitizer for Colorectal Cancer by Inhibiting the Radiation-induced Up-regulation of HIF-1α.

    Science.gov (United States)

    Okuno, Takayuki; Kawai, Kazushige; Hata, Keisuke; Murono, Koji; Emoto, Shigenobu; Kaneko, Manabu; Sasaki, Kazuhito; Nishikawa, Takeshi; Tanaka, Toshiaki; Nozawa, Hiroaki

    2018-06-01

    Hypoxia offers resistance to therapy in human solid tumors. The aim of the study was to investigate whether SN-38, the active metabolite of irinotecan, acts as a radiosensitizer through inhibition of hypoxia-inducible factor (HIF)-1α in the human colorectal cancer (CRC) cells. HT29 and SW480 cells were cultured with SN-38 (0-4 μM) immediately after irradiation (0-8 Gy). HIF-1α expression was assessed using flow-cytometry and western blot analysis. Cell proliferation was evaluated by the calcein assay. Apoptosis and cell cycle were determined by flow-cytometry. Radiation up-regulated HIF-1α, and SN-38 inhibited the radiation-induced HIF-1α. The combination of radiation and SN-38 inhibited cell proliferation more than radiation alone; treatment with SN-38 after radiation exposure did not increase the number of apoptotic cells, whereas, it enhanced the S and G 2 /M cell-cycle arrest and decreased the population of cells in G 1 Conclusion: SN-38 inhibits the radiation-induced up-regulation of HIF-1α and acts as a radiosensitizer by inducing cell-cycle arrest in CRC cells. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  2. Yugoslavia: Act of 21 November 1984 on radiation protection and the safe use of nuclear energy

    International Nuclear Information System (INIS)

    1985-01-01

    This Act which entered into force on 1 December 1984 repeals the 1976 Act on Protection against Ionizing Radiation and regulates most of the peaceful uses of nuclear energy and radiation protection in Yugoslavia. The Act lays down the licensing procedure for nuclear installations and covers safety-related questions in connection with standards, technical criteria etc. It also takes into account several areas regulated at international level, namely safeguards and physical protection of nuclear material. (NEA) [fr

  3. Conference on natural gas use state regulation and market dynamics in the Post 636/Energy Policy Act Era: Proceedings

    International Nuclear Information System (INIS)

    1993-01-01

    Reports in this Record of Proceedings explore a wide variety of issues related to the regulation of natural gas and its future role as one of the critical fuels that powers the economy of the United States. The focus is mainly on problems, obstacles, barriers, and the incredibly complex system created to bring a fuel from wellhead to burner tip. Individual papers have been cataloged separately

  4. Conference on natural gas use state regulation and market dynamics in the Post 636/Energy Policy Act Era: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    Reports in this Record of Proceedings explore a wide variety of issues related to the regulation of natural gas and its future role as one of the critical fuels that powers the economy of the United States. The focus is mainly on problems, obstacles, barriers, and the incredibly complex system created to bring a fuel from wellhead to burner tip. Individual papers have been cataloged separately.

  5. MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression

    Science.gov (United States)

    Aschrafi, Armaz; Verheijen, Jan M.; Gordebeke, Peter M.; Olde Loohuis, Nikkie F.; Menting, Kelly; Jager, Amanda; Palkovits, Miklos; Geenen, Bram; Kos, Aron; Martens, Gerard J.M.; Glennon, Jeffrey C.; Kaplan, Barry B.; Gaszner, Balázs; Kozicz, Tamas

    2016-01-01

    Background Altered levels of urocortin 1 (Ucn1) in the centrally projecting Edinger–Westphal nucleus (EWcp) of depressed suicide attempters or completers mediate the brain’s response to stress, while the mechanism regulating Ucn1 expression is unknown. We tested the hypothesis that microRNAs (miRNAs), which are vital fine-tuners of gene expression during the brain’s response to stress, have the capacity to modulate Ucn1 expression. Methods Computational analysis revealed that the Ucn1 3′ untranslated region contained a conserved binding site for miR-326. We examined miR-326 and Ucn1 levels in the EWcp of depressed suicide completers. In addition, we evaluated miR-326 and Ucn1 levels in the serum and the EWcp of a chronic variable mild stress (CVMS) rat model of behavioural despair and after recovery from CVMS, respectively. Gain and loss of miR-326 function experiments examined the regulation of Ucn1 by this miRNA in cultured midbrain neurons. Results We found reduced miR-326 levels concomitant with elevated Ucn1 levels in the EWcp of depressed suicide completers as well as in the EWcp of CVMS rats. In CVMS rats fully recovered from stress, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced the levels of this neuropeptide. Limitations This study lacked experiments showing that in vivo alteration of miR-326 levels alleviate depression-like behaviours. We show only correlative data for miR-325 and cocaine- and amphetamine-regulated transcript levels in the EWcp. Conclusion We identified miR-326 dysregulation in depressed suicide completers and characterized this miRNA as an upstream regulator of the Ucn1 neuropeptide expression in midbrain neurons. PMID:27045550

  6. The Small Heal Shock Protein αA-Crystallin Is Expressed In Pancreas and Acts as Negative Regulator of Carcinogenesis

    OpenAIRE

    Deng , Mi; Chen , Pei-Chao; Xie , Sisi; Zhao , Junqiong; Gong , Lili; Liu , Jinping; Zhang , Lan; Sun , Shuming; Liu , Jiao; Ma , Haili; Batra , Surinder; Li , David Wan-Cheng

    2010-01-01

    Abstract The small heat shock protein ?A-crystallin is a structural protein in the ocular lens. In addition, recent studies have also revealed that it is a molecular chaperone, an autokinase and a strong anti-apoptotic regulator. Besides its lenticular distribution, a previous study demonstrates that a detectable level of ?A-crystallin is found in other tissues including thymus and spleen. In the present study, we have re-examined the distribution of ?A-crystallin in various normal...

  7. The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development.

    Directory of Open Access Journals (Sweden)

    Hélène Chanut-Delalande

    Full Text Available BACKGROUND: Endocytosis is a key regulatory step of diverse signalling pathways, including receptor tyrosine kinase (RTK signalling. Hrs and Stam constitute the ESCRT-0 complex that controls the initial selection of ubiquitinated proteins, which will subsequently be degraded in lysosomes. It has been well established ex vivo and during Drosophila embryogenesis that Hrs promotes EGFR down regulation. We have recently isolated the first mutations of stam in flies and shown that Stam is required for air sac morphogenesis, a larval respiratory structure whose formation critically depends on finely tuned levels of FGFR activity. This suggest that Stam, putatively within the ESCRT-0 complex, modulates FGF signalling, a possibility that has not been examined in Drosophila yet. PRINCIPAL FINDINGS: Here, we assessed the role of the Hrs/Stam complex in the regulation of signalling activity during Drosophila development. We show that stam and hrs are required for efficient FGFR signalling in the tracheal system, both during cell migration in the air sac primordium and during the formation of fine cytoplasmic extensions in terminal cells. We find that stam and hrs mutant cells display altered FGFR/Btl localisation, likely contributing to impaired signalling levels. Electron microscopy analyses indicate that endosome maturation is impaired at distinct steps by hrs and stam mutations. These somewhat unexpected results prompted us to further explore the function of stam and hrs in EGFR signalling. We show that while stam and hrs together downregulate EGFR signalling in the embryo, they are required for full activation of EGFR signalling during wing development. CONCLUSIONS/SIGNIFICANCE: Our study shows that the ESCRT-0 complex differentially regulates RTK signalling, either positively or negatively depending on tissues and developmental stages, further highlighting the importance of endocytosis in modulating signalling pathways during development.

  8. miR-21 may acts as an oncomir by targeting RECK, a matrix metalloproteinase regulator, in prostate cancer

    Directory of Open Access Journals (Sweden)

    Reis Sabrina

    2012-05-01

    Full Text Available Abstract Background Prognosis of prostate cancer (PCa is based mainly in histological aspects together with PSA serum levels that not always reflect the real aggressive potential of the neoplasia. The micro RNA (miRNA mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase (MMP inhibitor RECK. Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line. Materials and methods To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21. To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction (qRT-PCR. Results The in vitro assays showed a decrease in expression levels of RECK after transfection with pre-miR-21, and an increase of MMP9 that is regulated by RECK compared to PCa cells treated with anti-miR-21. We defined three profiles to compare the prognostic factors. The first was characterized by miR-21 and RECK underexpression (N = 25 the second was characterized by miR-21 overexpression and RECK underexpression (N = 12, and the third was characterized by miR-21 underexpression and RECK overexpression (N = 16. From men who presented the second profile (miR-21 overexpression and RECK underexpression 91.7% were staged pT3. For the other two groups 48.0%, and 46.7% of patients were staged pT3 (p = 0.025. Conclusions Our results demonstrate RECK as a target of miR-21. We believe that miR-21 may be important in PCa progression through its regulation of RECK, a known regulator of tumor cell invasion.

  9. dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats

    International Nuclear Information System (INIS)

    Baladron, Victoriano; Ruiz-Hidalgo, Maria Jose; Nueda, Maria Luisa; Diaz-Guerra, Maria Jose M.; Garcia-Ramirez, Jose Javier; Bonvini, Ezio; Gubina, Elena; Laborda, Jorge

    2005-01-01

    The protein dlk, encoded by the Dlk1 gene, belongs to the Notch epidermal growth factor (EGF)-like family of receptors and ligands, which participate in cell fate decisions during development. The molecular mechanisms by which dlk regulates cell differentiation remain unknown. By using the yeast two-hybrid system, we found that dlk interacts with Notch1 in a specific manner. Moreover, by using luciferase as a reporter gene under the control of a CSL/RBP-Jk/CBF-1-dependent promoter in the dlk-negative, Notch1-positive Balb/c 14 cell line, we found that addition of synthetic dlk EGF-like peptides to the culture medium or forced expression of dlk decreases endogenous Notch activity. Furthermore, the expression of the gene Hes-1, a target for Notch1 activation, diminishes in confluent Balb/c14 cells transfected with an expression construct encoding for the extracellular EGF-like region of dlk. The expression of Dlk1 and Notch1 increases in 3T3-L1 cells maintained in a confluent state for several days, which is associated with a concomitant decrease in Hes-1 expression. On the other hand, the decrease of Dlk1 expression in 3T3-L1 cells by antisense cDNA transfection is associated with an increase in Hes-1 expression. These results suggest that dlk functionally interacts in vivo with Notch1, which may lead to the regulation of differentiation processes modulated by Notch1 activation and signaling, including adipogenesis

  10. IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.

    Science.gov (United States)

    Yoneyama, Yosuke; Lanzerstorfer, Peter; Niwa, Hideaki; Umehara, Takashi; Shibano, Takashi; Yokoyama, Shigeyuki; Chida, Kazuhiro; Weghuber, Julian; Hakuno, Fumihiko; Takahashi, Shin-Ichiro

    2018-04-11

    Insulin-like growth factor-I receptor (IGF-IR) preferentially regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent IGF-IR endocytosis determines how IGF induces such downstream signaling outputs. Here, we find that the insulin receptor substrate (IRS)-1 modulates how long ligand-activated IGF-IR remains at the cell surface before undergoing endocytosis in mammalian cells. IRS-1 interacts with the clathrin adaptor complex AP2. IRS-1, but not an AP2-binding-deficient mutant, delays AP2-mediated IGF-IR endocytosis after the ligand stimulation. Mechanistically, IRS-1 inhibits the recruitment of IGF-IR into clathrin-coated structures; for this reason, IGF-IR avoids rapid endocytosis and prolongs its activity on the cell surface. Accelerating IGF-IR endocytosis via IRS-1 depletion induces the shift from sustained to transient Akt activation and augments FoxO-mediated transcription. Our study establishes a new role for IRS-1 as an endocytic regulator of IGF-IR that ensures sustained IGF bioactivity, independent of its classic role as an adaptor in IGF-IR signaling. © 2018, Yoneyama et al.

  11. Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory.

    Science.gov (United States)

    Kojima, Nobuhiko; Borlikova, Gilyana; Sakamoto, Toshiro; Yamada, Kazuyuki; Ikeda, Toshio; Itohara, Shigeyoshi; Niki, Hiroaki; Endo, Shogo

    2008-06-18

    Long-lasting neuronal plasticity as well as long-term memory (LTM) requires de novo synthesis of proteins through dynamic regulation of gene expression. cAMP-responsive element (CRE)-mediated gene transcription occurs in an activity-dependent manner and plays a pivotal role in neuronal plasticity and LTM in a variety of species. To study the physiological role of inducible cAMP early repressor (ICER), a CRE-mediated gene transcription repressor, in neuronal plasticity and LTM, we generated two types of ICER mutant mice: ICER-overexpressing (OE) mice and ICER-specific knock-out (KO) mice. Both ICER-OE and ICER-KO mice show no apparent abnormalities in their development and reproduction. A comprehensive battery of behavioral tests revealed no robust changes in locomotor activity, sensory and motor functions, and emotional responses in the mutant mice. However, long-term conditioned fear memory was attenuated in ICER-OE mice and enhanced in ICER-KO mice without concurrent changes in short-term fear memory. Furthermore, ICER-OE mice exhibited retardation of kindling development, whereas ICER-KO mice exhibited acceleration of kindling. These results strongly suggest that ICER negatively regulates the neuronal processes required for long-term fear memory and neuronal plasticity underlying kindling epileptogenesis, possibly through suppression of CRE-mediated gene transcription.

  12. Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts

    International Nuclear Information System (INIS)

    Wang Zhirong; Chen Yan; Labinskyy, Nazar; Hsieh Tzechen; Ungvari, Zoltan; Wu, Joseph M.

    2006-01-01

    Epidemiologic studies suggest that low to moderate consumption of red wine is inversely associated with the risk of coronary heart disease; the protection is in part attributed to grape-derived polyphenols, notably trans-resveratrol, present in red wine. It is not clear whether the cardioprotective effects of resveratrol can be reproduced by standardized grape extracts (SGE). In the present studies, we determined, using cultured human aortic smooth muscle cells (HASMC), growth and specific gene responses to resveratrol and SGE provided by the California Table Grape Commission. Suppression of HASMC proliferation by resveratrol was accompanied by a dose-dependent increase in the expression of tumor suppressor gene p53 and heat shock protein HSP27. Using resveratrol affinity chromatography and biochemical fractionation procedures, we showed by immunoblot analysis that treatment of HASMC with resveratrol increased the expression of quinone reductase I and II, and also altered their subcellular distribution. Growth of HASMC was significantly inhibited by 70% ethanolic SGE; however, gene expression patterns in various cellular compartments elicited in response to SGE were substantially different from those observed in resveratrol-treated cells. Further, SGE also differed from resveratrol in not being able to induce relaxation of rat carotid arterial rings. These results indicate that distinct mechanisms are involved in the regulation of HASMC growth and gene expression by SGE and resveratrol

  13. Lung function after cold-water dives with a standard scuba regulator or full-face-mask during wintertime.

    Science.gov (United States)

    Uhlig, Florian; Muth, Claus-Martin; Tetzlaff, Kay; Koch, Andreas; Leberle, Richard; Georgieff, Michael; Winkler, Bernd E

    2014-06-01

    Full-face-masks (FFM) prevent the diver's face from cold and can support nasal breathing underwater. The aim of the study was to evaluate the effect of the use of FFMs on lung function and wellbeing. Twenty-one, healthy, non-asthmatic divers performed two cold-water dives (4⁰C, 25 min, 10 metres' depth) - one with a FFM and the other with a standard scuba regulator (SSR). Spirometry was performed before and after each dive and well-being and cold sensation were assessed after the dives. Significant decreases in forced vital capacity (FVC), forced expiratory volume in one second (FEV₁) and midexpiratory flow at 75% of FVC (MEF₇₅) occurred after both FFM and SSR dives. Changes in FVC and FEV₁ did not differ significantly between FFM and SSR dives. However, the mid-expiratory flows measured at 50% and 25% of FVC (MEF₅₀ and MEF₂₅) were significantly lower 10 minutes after the FFM dive compared to 10 minutes after the SSR dive. The wellbeing and cold sensation of the divers were significantly improved with FFM dives compared to SSR dives. Cold-water dives during wintertime can be associated with airway narrowing. During cold-water dives, the use of a FFM appears to reduce the cold sensation and enhance the well-being of the divers. However, a FFM does not appear to prevent airway narrowing in healthy, non-asthmatic subjects.

  14. Identification of the C-terminal domain of Daxx acts as a potential regulator of intracellular cholesterol synthesis in HepG2 cells

    International Nuclear Information System (INIS)

    Sun, Shaowei; Wen, Juan; Qiu, Fei; Yin, Yufang; Xu, Guina; Li, Tianping; Nie, Juan; Xiong, Guozuo; Zhang, Caiping; Liao, Duangfang; Chen, Jianxiong; Tuo, Qinhui

    2016-01-01

    Daxx is a highly conserved nuclear transcriptional factor, which has been implicated in many nuclear processes including transcription and cell cycle regulation. Our previous study demonstrated Daxx also plays a role in regulation of intracellular cholesterol content. Daxx contains several domains that are essential for interaction with a growing number of proteins. To delineate the underlying mechanism of hypocholesterolemic activity of Daxx, we constructed a set of plasmids which can be used to overexpress different fragments of Daxx and transfected to HepG2 cells. We found that the C- terminal region Daxx626–740 clearly reduced intracellular cholesterol levels and inhibited the expression of SREBPs and SCAP. In GST pull-down experiments and Double immunofluorescence assays, Daxx626–740 was demonstrated to bind directly to androgen receptor (AR). Our findings suggest that the interaction of Daxx626-740 and AR abolishes the AR-mediated activation of SCAP/SREBPs pathway, which suppresses the de novo cholesterol synthesis. Thus, C-terminal domain of Daxx acts as a potential regulator of intracellular cholesterol content in HepG2 cells. - Highlights: • Daxx C-terminal domain reduces cholesterol levels. • Daxx C-terminal domain binds directly to AR. • The interaction of Daxx C-terminal domain and AR suppresses cholesterol synthesis.

  15. Towards an integrated design of voluntary approaches and standardization processes: An analysis of issues and trends in the Italian regulation on ground coupled heat pumps

    International Nuclear Information System (INIS)

    Rizzi, Francesco; Frey, Marco; Iraldo, Fabio

    2011-01-01

    Highlights: → We investigate GCHP regulation development from an entrepreneurial perspective. → Threats in booming market orient entrepreneurs toward green management. → Command and control regulation is not sufficient to guarantee market sustainability. → Voluntary regulation encourage best performers to invest in long-term strategies. → Bottom-up regulation design advances integration of process and product standards. - Abstract: Despite the lack of specific incentives, ground coupled heat pump (GCHP) installations are booming in Italy both in the private and public sectors. Such rapid growth is coupled with increasing concern for environmental and technical performances since no comprehensive regulation and reliable standards currently exist. This paper discusses potential schemes aimed at balancing mandatory and voluntary requirements by using SWOT-based techniques and examining the opinions of sectoral leaders. The analysis suggests that standardization and voluntary schemes are perceived as efficient and effective tools to encourage the greening of Italian GCHP-SMEs in the short-term while laying the foundations for sustainable policies in the longer run. A potential scheme is discussed that was simulated by reflecting the supply-side of the market, and which involves process and product standards.

  16. Towards an integrated design of voluntary approaches and standardization processes: An analysis of issues and trends in the Italian regulation on ground coupled heat pumps

    Energy Technology Data Exchange (ETDEWEB)

    Rizzi, Francesco, E-mail: f.rizzi@sssup.it [Scuola Superiore Sant' Anna - Istituto di Management, P.zza Martiri della Liberta 33, 56127 Pisa (Italy); Frey, Marco, E-mail: frey@sssup.it [Scuola Superiore Sant' Anna - Istituto di Management, P.zza Martiri della Liberta 33, 56127 Pisa (Italy); Iraldo, Fabio, E-mail: f.iraldo@sssup.it [Scuola Superiore Sant' Anna - Istituto di Management, P.zza Martiri della Liberta 33, 56127 Pisa (Italy)

    2011-09-15

    Highlights: {yields} We investigate GCHP regulation development from an entrepreneurial perspective. {yields} Threats in booming market orient entrepreneurs toward green management. {yields} Command and control regulation is not sufficient to guarantee market sustainability. {yields} Voluntary regulation encourage best performers to invest in long-term strategies. {yields} Bottom-up regulation design advances integration of process and product standards. - Abstract: Despite the lack of specific incentives, ground coupled heat pump (GCHP) installations are booming in Italy both in the private and public sectors. Such rapid growth is coupled with increasing concern for environmental and technical performances since no comprehensive regulation and reliable standards currently exist. This paper discusses potential schemes aimed at balancing mandatory and voluntary requirements by using SWOT-based techniques and examining the opinions of sectoral leaders. The analysis suggests that standardization and voluntary schemes are perceived as efficient and effective tools to encourage the greening of Italian GCHP-SMEs in the short-term while laying the foundations for sustainable policies in the longer run. A potential scheme is discussed that was simulated by reflecting the supply-side of the market, and which involves process and product standards.

  17. An Act to regulate the keeping and use of radioactive substances, irradiating apparatus and certain electronic products, and for matters incidental thereto (No. 440 of 1975)

    International Nuclear Information System (INIS)

    1975-01-01

    This Radiation Safety Act 1975 which applies to radioactive substances and irradiating apparatus is a framework Act governing activities involving their possession and applications including their disposal. It makes provision for the duties and powers of the authorities responsible for administering the Act (the Radiological Council), licensing requirements and exemptions therefrom, registration of such substances and apparatus, inspection procedures and liability under the Act. The Radioactive Substances Act 1954, the Radioactive Substances Act Amendment Acts 1960 and 1964 are repealed. (NEA) [fr

  18. Analysis of a cis-Acting Element Involved in Regulation by Estrogen of Human Angiotensinogen Gene Expression.

    Science.gov (United States)

    Zhao, Yan-Yan; Sun, Kai-Lai; Ashok, Kumar

    1998-01-01

    The work was aimed to identify the estrogen responsive element in the human angiotensinogen gene. The nucleotide sequence between the transcription initiation site and TATA box in angiotensinogen gene promoter was found to be strongly homologous with the consensus estrogen responsive element. This sequence was confirmed as the estrogen responsive element (HAG ERE) by electrophoretic mobility shift assay. The recombinant expression vectors were constructed in which chloramphenicol acetyltransferase (CAT) reporter gene was driven by angiotensinogen core promoter with HAG ERE of by TK core promoter with multiplied HAG ERE, and were used in cotransfection with the human estrogen receptor expression vector into HepG(2) cells; CAT assays showed an increase of the CAT activity on 17beta-estradiol treatment in those transfectants. These results suggest that the human angiotensinogen gene is transcriptionally up-regulated by estrogen through the estrogen responsive element near TATA box of the promoter.

  19. 40 CFR 413.74 - Pretreatment standards for existing sources.

    Science.gov (United States)

    2010-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS ELECTROPLATING POINT SOURCE CATEGORY Electroless Plating Subcategory... regulation must implement the toxic organic management plan approved by the control authority. (Secs. 301, 304, 306, 307, 308, and 501 of the Clean Water Act (the Federal Water Pollution Control Act Amendments...

  20. LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants

    Science.gov (United States)

    2014-01-01

    Background Arabidopsis ZBF1/MYC2bHLH transcription factor is a repressor of photomorphogenesis, and acts as a point of cross talk in light, abscisic acid (ABA) and jasmonic acid (JA) signaling pathways. MYC2 also functions as a positive regulator of lateral root development and flowering time under long day conditions. However, the function of MYC2 in growth and development remains unknown in crop plants. Results Here, we report the functional analyses of LeMYC2 in tomato (Lycopersicon esculentum). The amino acid sequence of LeMYC2 showed extensive homology with Arabidopsis MYC2, containing the conserved bHLH domain. To study the function of LeMYC2 in tomato, overexpression and RNA interference (RNAi) LeMYC2 tomato transgenic plants were generated. Examination of seedling morphology, physiological responses and light regulated gene expression has revealed that LeMYC2 works as a negative regulator of blue light mediated photomorphogenesis. Furthermore, LeMYC2 specifically binds to the G-box of LeRBCS-3A promoter. Overexpression of LeMYC2 has led to increased root length with more number of lateral roots. The tomato plants overexpressing LeMYC2 have reduced internode distance with more branches, and display the opposite morphology to RNAi transgenic lines. Furthermore, this study shows that LeMYC2 promotes ABA and JA responsiveness. Conclusions Collectively, this study highlights that working in light, ABA and JA signaling pathways LeMYC2 works as an important regulator for growth and development in tomato plants. PMID:24483714

  1. Nuclear Regulatory Authority Act, 2015 (Act 895)

    International Nuclear Information System (INIS)

    2015-04-01

    An Act to establish a Nuclear Regulatory Authority in Ghana. This Act provides for the regulation and management of activities and practices for the peaceful use of nuclear material or energy, and to provide for the protection of persons and the environment against the harmful effects of radiation; and to ensure the effective implementation of the country’s international obligations and for related matters. This Act replaced the Radiation Protection Instrument, of 1993 (LI 1559).

  2. The Ste20 kinase misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals.

    Science.gov (United States)

    Su, Y C; Maurel-Zaffran, C; Treisman, J E; Skolnik, E Y

    2000-07-01

    We have previously shown that the Ste20 kinase encoded by misshapen (msn) functions upstream of the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase module in Drosophila. msn is required to activate the Drosophila JNK, Basket (Bsk), to promote dorsal closure of the embryo. A mammalian homolog of Msn, Nck interacting kinase, interacts with the SH3 domains of the SH2-SH3 adapter protein Nck. We now show that Msn likewise interacts with Dreadlocks (Dock), the Drosophila homolog of Nck. dock is required for the correct targeting of photoreceptor axons. We have performed a structure-function analysis of Msn in vivo in Drosophila in order to elucidate the mechanism whereby Msn regulates JNK and to determine whether msn, like dock, is required for the correct targeting of photoreceptor axons. We show that Msn requires both a functional kinase and a C-terminal regulatory domain to activate JNK in vivo in Drosophila. A mutation in a PXXP motif on Msn that prevents it from binding to the SH3 domains of Dock does not affect its ability to rescue the dorsal closure defect in msn embryos, suggesting that Dock is not an upstream regulator of msn in dorsal closure. Larvae with only this mutated form of Msn show a marked disruption in photoreceptor axon targeting, implicating an SH3 domain protein in this process; however, an activated form of Msn is not sufficient to rescue the dock mutant phenotype. Mosaic analysis reveals that msn expression is required in photoreceptors in order for their axons to project correctly. The data presented here genetically link msn to two distinct biological events, dorsal closure and photoreceptor axon pathfinding, and thus provide the first evidence that Ste20 kinases of the germinal center kinase family play a role in axonal pathfinding. The ability of Msn to interact with distinct classes of adapter molecules in dorsal closure and photoreceptor axon pathfinding may provide the flexibility that allows it to link to distinct

  3. Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2.

    Directory of Open Access Journals (Sweden)

    Claire L Russell

    Full Text Available It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42. However, the underlying molecular and cellular mechanisms behind these deficits are not fully understood. Here we provide evidence of a mechanism by which Aβ42 affects synaptic transmission regulating neurotransmitter release.We first showed that application of 50 nM Aβ42 in cultured neurones is followed by its internalisation and translocation to synaptic contacts. Interestingly, our results demonstrate that with time, Aβ42 can be detected at the presynaptic terminals where it interacts with Synaptophysin. Furthermore, data from dissociated hippocampal neurons as well as biochemical data provide evidence that Aβ42 disrupts the complex formed between Synaptophysin and VAMP2 increasing the amount of primed vesicles and exocytosis. Finally, electrophysiology recordings in brain slices confirmed that Aβ42 affects baseline transmission.Our observations provide a necessary and timely insight into cellular mechanisms that underlie the initial pathological events that lead to synaptic dysfunction in Alzheimer's disease. Our results demonstrate a new mechanism by which Aβ42 affects synaptic activity.

  4. The Scc2/Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions

    Science.gov (United States)

    Lopez-Serra, Lidia; Kelly, Gavin; Patel, Harshil; Stewart, Aengus; Uhlmann, Frank

    2014-01-01

    The cohesin complex is at the heart of many chromosomal activities, including sister chromatid cohesion and transcriptional regulation1-3. Cohesin loading onto chromosomes depends on the Scc2/Scc4 cohesin loader complex4-6, but the chromatin features that form cohesin loading sites remain poorly understood. Here, we show that the RSC chromatin remodeling complex recruits budding yeast Scc2/Scc4 to broad nucleosome-free regions, that the cohesin loader itself helps to maintain. Consequently, inactivation of the cohesin loader or RSC complex have similar effects on nucleosome positioning, gene expression and sister chromatid cohesion. These results reveal an intimate link between local chromatin structure and higher order chromosome architecture. Our findings pertain to the similarities between two severe human disorders, Cornelia de Lange syndrome, caused by mutations in the human cohesin loader, and Coffin-Siris syndrome, resulting from mutations in human RSC complex components7-9. Both could arise from gene misregulation due to related changes in the nucleosome landscape. PMID:25173104

  5. Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors

    International Nuclear Information System (INIS)

    Reue, K.; Leff, T.; Breslow, J.L.

    1988-01-01

    Apolipoprotein CIII (apoCIII) is a major protein constituent of triglyceride-rich lipoproteins and is synthesized primarily in the liver. Cis-acting DNA elements required for liver-specific apoCIII gene transcription were identified with transient expression assays in the human hepatoma (HepG2) and epithelial carcinoma (HeLa) cell lines. In liver cells, 821 nucleotides of the human apoCIII gene 5'-flanking sequence were required for maximum levels of gene expression, while the proximal 110 nucleotides alone were sufficient. No expression was observed in similar studies with HeLa cells. The level of expression was modulated by a combination of positive and negative cis-acting sequences, which interact with distinct sets of proteins from liver and HeLa cell nuclear extracts. The proximal positive regulatory region shares homology with similarly located sequences of other genes strongly expressed in the liver, including α 1 -antitrypsin and other apolipoprotein genes. The negative regulatory region is striking homologous to the human β-interferon gene regulatory element. The distal positive region shares homology with some viral enhancers and has properties of a tissue-specific enhancer. The regulation of the apoCIII gene is complex but shares features with other genes, suggesting shuffling of regulatory elements as a common mechanism for cell type-specific gene expression

  6. Auxin and ABA act as central regulators of developmental networks associated with paradormancy in Canada thistle (Cirsium arvense)

    KAUST Repository

    Anderson, James V.

    2012-05-13

    Abstract Dormancy in underground vegetative buds of Canada thistle, an herbaceous perennial weed, allows escape from current control methods and contributes to its invasive nature. In this study, ∼65 % of root sections obtained from greenhouse propagated Canada thistle produced new vegetative shoots by 14 days post-sectioning. RNA samples obtained from sectioned roots incubated 0, 24, 48, and 72 h at 25°C under 16:8 h light-dark conditions were used to construct four MID-tagged cDNA libraries. Analysis of in silico data obtained using Roche 454 GS-FLX pyrosequencing technologies identified molecular networks associated with paradormancy release in underground vegetative buds of Canada thistle. Sequencing of two replicate plates produced ∼2.5 million ESTs with an average read length of 362 bases. These ESTs assembled into 67358 unique sequences (21777 contigs and 45581 singlets) and annotation against the Arabidopsis database identified 15232 unigenes. Among the 15232 unigenes, we identified processes enriched with transcripts involved in plant hormone signaling networks. To follow-up on these results, we examined hormone profiles in roots, which identified changes in abscisic acid (ABA) and ABA metabolites, auxins, and cytokinins post-sectioning. Transcriptome and hormone profiling data suggest that interaction between auxin- and ABA-signaling regulate paradormancy maintenance and release in underground adventitious buds of Canada thistle. Our proposed model shows that sectioning-induced changes in polar auxin transport alters ABA metabolism and signaling, which further impacts gibberellic acid signaling involving interactions between ABA and FUSCA3. Here we report that reduced auxin and ABA-signaling, in conjunction with increased cytokinin biosynthesis post-sectioning supports a model where interactions among hormones drives molecular networks leading to cell division, differentiation, and vegetative outgrowth. ©Springer-Verlag (outside the USA) 2012.

  7. Regulator's Workshop on The Role of Future Society and Biosphere in Demonstrating Compliance with High-Level Radioactive Waste Disposal Standards and Regulations

    Energy Technology Data Exchange (ETDEWEB)

    Avila, R. [Swedish Radiation Protection Authority, Stockholm (Sweden); Blommaert, W. [Agence Federale de Controle Nucleaire, Bruxelles (Belgium); Clark, R. [US Environmental Protection Agency (United States)] [and others

    2002-09-01

    This report summarizes the proceedings of a workshop, co-sponsored by the U.S. Environmental Protection Agency (US EPA) and the Swedish Radiation Protection Authority (SSI). The invitations to participate in the Workshop were primarily extended to authorities in countries with major nuclear waste programs involving geological disposal and using performance assessment methodology. The main objective of the Workshop was to develop a common understanding among regulators of the role of society and the biosphere in demonstrating compliance with regulations.

  8. Regulator's Workshop on The Role of Future Society and Biosphere in Demonstrating Compliance with High-Level Radioactive Waste Disposal Standards and Regulations

    International Nuclear Information System (INIS)

    Avila, R.; Blommaert, W.; Clark, R.

    2002-09-01

    This report summarizes the proceedings of a workshop, co-sponsored by the U.S. Environmental Protection Agency (US EPA) and the Swedish Radiation Protection Authority (SSI). The invitations to participate in the Workshop were primarily extended to authorities in countries with major nuclear waste programs involving geological disposal and using performance assessment methodology. The main objective of the Workshop was to develop a common understanding among regulators of the role of society and the biosphere in demonstrating compliance with regulations

  9. A Radish Basic Helix-Loop-Helix Transcription Factor, RsTT8 Acts a Positive Regulator for Anthocyanin Biosynthesis

    Directory of Open Access Journals (Sweden)

    Sun-Hyung Lim

    2017-11-01

    Full Text Available The MYB-bHLH-WDR (MBW complex activates anthocyanin biosynthesis through the transcriptional regulation. RsMYB1 has been identified as a key player in anthocyanin biosynthesis in red radish (Raphanus sativus L., but its partner bHLH transcription factor (TF remains to be determined. In this study, we isolated a bHLH TF gene from red radish. Phylogenetic analysis indicated that this gene belongs to the TT8 clade of the IIIF subgroup of bHLH TFs, and we thus designated this gene RsTT8. Subcellular localization analysis showed that RsTT8-sGFP was localized to the nuclei of Arabidopsis thaliana protoplasts harboring the RsTT8-sGFP construct. We evaluated anthocyanin biosynthesis and RsTT8 expression levels in three radish varieties (N, C, and D that display different red phenotypes in the leaves, root flesh, and root skins. The root flesh of the C variety and the leaves and skins of the D variety exhibit intense red pigmentation; in these tissues, RsTT8 expression showed totally positive association with the expression of RsMYB1 TF and of five of eight tested anthocyanin biosynthesis genes (i.e., RsCHS, RsCHI, RsF3H, RsDFR, and RsANS. Heterologous co-expression of both RsTT8 and RsMYB1 in tobacco leaves dramatically increased the expression of endogenous anthocyanin biosynthesis genes and anthocyanin accumulation. Furthermore, a yeast two-hybrid assay showed that RsTT8 interacts with RsMYB1 at the MYB-interacting region (MIR, and a transient transactivation assay indicated that RsTT8 activates the RsCHS and RsDFR promoters when co-expressed with RsMYB1. Complementation of the Arabidopsis tt8-1 mutant, which lacks red pigmentation in the leaves and seeds, with RsTT8 restored red pigmentation, and resulted in high anthocyanin and proanthocyanidin contents in the leaves and seeds, respectively. Together, these results show that RsTT8 functions as a regulatory partner with RsMYB1 during anthocyanin biosynthesis.

  10. Amino acids and insulin act additively to regulate components of the ubiquitin-proteasome pathway in C2C12 myotubes

    Directory of Open Access Journals (Sweden)

    Lomax Michael A

    2007-03-01

    Full Text Available Abstract Background The ubiquitin-proteasome system is the predominant pathway for myofibrillar proteolysis but a previous study in C2C12 myotubes only observed alterations in lysosome-dependent proteolysis in response to complete starvation of amino acids or leucine from the media. Here, we determined the interaction between insulin and amino acids in the regulation of myotube proteolysis Results Incubation of C2C12 myotubes with 0.2 × physiological amino acids concentration (0.2 × PC AA, relative to 1.0 × PC AA, significantly increased total proteolysis and the expression of 14-kDa E2 ubiquitin conjugating enzyme (p Conclusion In a C2C12 myotube model of myofibrillar protein turnover, amino acid limitation increases proteolysis in a ubiquitin-proteasome-dependent manner. Increasing amino acids or leucine alone, act additively with insulin to down regulate proteolysis and expression of components of ubiquitin-proteasome pathway. The effects of amino acids on proteolysis but not insulin and leucine, are blocked by inhibition of the mTOR signalling pathway.

  11. The response regulator expM is essential for the virulence of Erwinia carotovora subsp. carotovora and acts negatively on the sigma factor RpoS (sigma s).

    Science.gov (United States)

    Andersson, R A; Palva, E T; Pirhonen, M

    1999-07-01

    The main virulence factors of Erwinia carotovora subsp. carotovora, the secreted, extracellular cell-wall-degrading enzymes, are controlled by several regulatory mechanisms. We have isolated transposon mutants with reduced virulence on tobacco. One of these mutants, with a mutation in a gene designated expM, was characterized in this study. This mutant produces slightly reduced amounts of extracellular enzymes in vitro and the secretion of the enzymes is also affected. The expM wild-type allele was cloned together with an upstream gene, designated expL, that has an unknown function. The expM gene was sequenced and found to encode a protein with similarity to the RssB/SprE protein of Escherichia coli and the MviA protein of Salmonella typhimurium. These proteins belong to a new type of two-component response regulators that negatively regulate the stability of the Sigma factor RpoS (sigma s) at the protein level. The results of this study suggest that ExpM has a similar function in E. carotovora subsp. carotovora. We also provide evidence that the overproduction of RpoS in the expM mutant is an important factor for the reduced virulence phenotype and that it partly causes the observed phenotype seen in vitro. However, an expM/rpoS double mutant is still affected in secretion of extracellular enzymes, suggesting that ExpM in addition to RpoS also acts on other targets.

  12. Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in Arabidopsis.

    Science.gov (United States)

    Xiong, Fangjie; Zhang, Rui; Meng, Zhigang; Deng, Kexuan; Que, Yumei; Zhuo, Fengping; Feng, Li; Guo, Sundui; Datla, Raju; Ren, Maozhi

    2017-01-01

    The components of the target of rapamycin (TOR) signaling pathway have been well characterized in heterotrophic organisms from yeast to humans. However, because of rapamycin insensitivity, embryonic lethality in tor null mutants and a lack of reliable ways of detecting TOR protein kinase in higher plants, the key players upstream and downstream of TOR remain largely unknown in plants. Using engineered rapamycin-sensitive Binding Protein 12-2 (BP12-2) plants, the present study showed that combined treatment with rapamycin and active-site TOR inhibitors (asTORis) results in synergistic inhibition of TOR activity and plant growth in Arabidopsis. Based on this system, we revealed that TOR signaling plays a crucial role in modulating the transition from heterotrophic to photoautotrophic growth in Arabidopsis. Ribosomal protein S6 kinase 2 (S6K2) was identified as a direct downstream target of TOR, and the growth of TOR-suppressed plants could be rescued by up-regulating S6K2. Systems, genetic, and biochemical analyses revealed that Brassinosteriod Insensitive 2 (BIN2) acts as a novel downstream effector of S6K2, and the phosphorylation of BIN2 depends on TOR-S6K2 signaling in Arabidopsis. By combining pharmacological with genetic and biochemical approaches, we determined that the TOR-S6K2-BIN2 signaling pathway plays important roles in regulating the photoautotrophic growth of Arabidopsis. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

  13. Regulation

    International Nuclear Information System (INIS)

    Ballereau, P.

    1999-01-01

    The different regulations relative to nuclear energy since the first of January 1999 are given here. Two points deserve to be noticed: the decree of the third august 1999 authorizing the national Agency for the radioactive waste management to install and exploit on the commune of Bures (Meuse) an underground laboratory destined to study the deep geological formations where could be stored the radioactive waste. The second point is about the uranium residues and the waste notion. The judgment of the administrative tribunal of Limoges ( 9. july 1998) forbidding the exploitation of a storage installation of depleted uranium considered as final waste and qualifying it as an industrial waste storage facility has been annulled bu the Court of Appeal. It stipulated that, according to the law number 75663 of the 15. july 1965, no criteria below can be applied to depleted uranium: production residue (possibility of an ulterior enrichment), abandonment of a personal property or simple intention to do it ( future use aimed in the authorization request made in the Prefecture). This judgment has devoted the primacy of the waste notion on this one of final waste. (N.C.)

  14. Accounting standards

    NARCIS (Netherlands)

    Stellinga, B.; Mügge, D.

    2014-01-01

    The European and global regulation of accounting standards have witnessed remarkable changes over the past twenty years. In the early 1990s, EU accounting practices were fragmented along national lines and US accounting standards were the de facto global standards. Since 2005, all EU listed

  15. 7 CFR 917.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 917.2 Section 917.2 Agriculture Regulations of... Order Regulating Handling Definitions § 917.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended, and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as...

  16. 7 CFR 915.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 915.2 Section 915.2 Agriculture Regulations of... Regulating Handling Definitions § 915.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48...

  17. 7 CFR 982.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 982.2 Section 982.2 Agriculture Regulations of... Order Regulating Handling Definitions § 982.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (7 U.S.C...

  18. 7 CFR 906.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 906.2 Section 906.2 Agriculture Regulations of... GRANDE VALLEY IN TEXAS Order Regulating Handling Definitions § 906.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as re-enacted and amended by the Agricultural Marketing Agreement Act of...

  19. 7 CFR 916.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 916.2 Section 916.2 Agriculture Regulations of... Regulating Handling Definitions § 916.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48...

  20. 7 CFR 993.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 993.2 Section 993.2 Agriculture Regulations of... Regulating Handling Definitions § 993.2 Act. Act means Public Act No. 10, 73d Congress, as amended and reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (7 U.S.C. 601 et seq.). ...

  1. 7 CFR 923.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 923.2 Section 923.2 Agriculture Regulations of... IN WASHINGTON Order Regulating Handling Definitions § 923.2 Act. Act means Public Act No. 10, 73d... Act of 1937, as amended (48 Stat. 31, as amended; 7 U.S.C. 601 et seq.; 68 Stat. 906, 1047). ...

  2. 7 CFR 927.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 927.2 Section 927.2 Agriculture Regulations of... Regulating Handling Definitions § 927.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48...

  3. 7 CFR 946.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 946.2 Section 946.2 Agriculture Regulations of... Regulating Handling Definitions § 946.2 Act. Act means Public Act No. 10, 73d Congress, as amended and reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as...

  4. 7 CFR 989.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 989.2 Section 989.2 Agriculture Regulations of... CALIFORNIA Order Regulating Handling Definitions § 989.2 Act. Act means Public Act No. 10, 73d Congress, as amended, and as re-enacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended...

  5. 7 CFR 987.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 987.2 Section 987.2 Agriculture Regulations of... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of...

  6. 7 CFR 948.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 948.2 Section 948.2 Agriculture Regulations of... Regulating Handling Definitions § 948.2 Act. Act means Public Act No. 10 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (sections 1-19, 48...

  7. 7 CFR 922.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 922.2 Section 922.2 Agriculture Regulations of... WASHINGTON Order Regulating Handling Definitions § 922.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of...

  8. Development of standards and investigation of safety examination items for advancement of safety regulation of fast breeder reactor

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-15

    The purposes of this study are to prepare the fuel technical standard and the structure and materials standard of fast breeder reactors (FBRs), and to develop the requirements in a reactor establishment permission. The objects of this study are mainly the Monju high performance core and a demonstration FBR. In JFY 2012, the following results were obtained. As for the fuel technical standard, the fuel technical standard adapting the examination of integrity of the FBR fuels was prepared based on the information and data obtained in this study. As for the structure and material standard, the investigation of the revised parts of the standard was carried out. And as for the examination of the safety requirements, safety evaluation items for the future FBR plant and the fission products to be considered in a reactor establishment permission were investigated and examined. (author)

  9. 28 CFR 37.12 - Standards.

    Science.gov (United States)

    2010-07-01

    ... Administration DEPARTMENT OF JUSTICE PROCEDURES FOR COORDINATING THE INVESTIGATION OF COMPLAINTS OR CHARGES OF... OF THE REHABILITATION ACT OF 1973 § 37.12 Standards. In any investigation, compliance review, hearing... 29 CFR part 1630, and case law arising under such regulations, in determining whether a recipient of...

  10. 29 CFR 1977.10 - Proceedings under or related to the Act.

    Science.gov (United States)

    2010-07-01

    ... OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 Specific Protections § 1977.10 Proceedings under or related to the... standard under section 6(f) of the Act and employee appeal of an Occupational Safety and Health Review... 1977.10 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION...

  11. 16 CFR 1105.3 - A more satisfactory standard.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false A more satisfactory standard. 1105.3 Section 1105.3 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS... satisfactory standard. In considering whether a contribution is likely to result in a more satisfactory...

  12. MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation

    Directory of Open Access Journals (Sweden)

    Jiang Li

    2011-01-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" as miR-148a and miR-152. Although aberrant expression of miR-148b has been observed in several types of cancer, its pathophysiologic role and relevance to tumorigenesis are still largely unknown. The purpose of this study was to elucidate the molecular mechanisms by which miR-148b acts as a tumor suppressor in gastric cancer. Results We showed significant down-regulation of miR-148b in 106 gastric cancer tissues and four gastric cancer cell lines, compared with their non-tumor counterparts by real-time RT-PCR. In situ hybridization of ten cases confirmed an overt decrease in the level of miR-148b in gastric cancer tissues. Moreover, the expression of miR-148b was demonstrated to be associated with tumor size (P = 0.027 by a Mann-Whitney U test. We also found that miR-148b could inhibit cell proliferation in vitro by MTT assay, growth curves and an anchorage-independent growth assay in MGC-803, SGC-7901, BGC-823 and AGS cells. An experiment in nude mice revealed that miR-148b could suppress tumorigenicity in vivo. Using a luciferase activity assay and western blot, CCKBR was identified as a target of miR-148b in cells. Moreover, an obvious inverse correlation was observed between the expression of CCKBR protein and miR-148b in 49 pairs of tissues (P = 0.002, Spearman's correlation. Conclusions These findings provide important evidence that miR-148b targets CCKBR and is significant in suppressing gastric cancer cell growth. Maybe miR-148b would become a potential biomarker and therapeutic target against gastric cancer.

  13. Reconceptualizing Civil Regulation

    DEFF Research Database (Denmark)

    Galang, Roberto Martin; Castello, Itziar

    2011-01-01

    This article re-conceptualizes the notion of civil regulation, through an analysis of 775 projects by firms located in 21 Asian countries, wherein we map the state of civil regulation initiatives in the region. We challenge two established assumptions in the Corporate Social Responsibility litera....... Finally, we argue that, in Asia, governments act as a structuration mechanism which challenges the current understanding of CSR.......This article re-conceptualizes the notion of civil regulation, through an analysis of 775 projects by firms located in 21 Asian countries, wherein we map the state of civil regulation initiatives in the region. We challenge two established assumptions in the Corporate Social Responsibility...... and environmental standards; but also that local, small and medium companies play a key role in the development of Asian civil regulation. We call this second finding the “CSR importation trap”. Our findings are supported by evidence on the limitations in the interchangeable properties of business and governments...

  14. 49 CFR 99.735-1 - Cross-reference to ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Cross-reference to ethical conduct standards and... Transportation EMPLOYEE RESPONSIBILITIES AND CONDUCT General § 99.735-1 Cross-reference to ethical conduct... the executive branch-wide Standards of Ethical Conduct at 5 CFR part 2635, the Department of...

  15. Adjustment of Energy requirements in TEK; TEK= Technical Regulations under the Norwegian Planning and Building Act; Justering av energikrav i TEK

    Energy Technology Data Exchange (ETDEWEB)

    Thyholt, Marit; Dokka, Tor Helge; Schild, Peter; Grini, Catherine; Mysen, Mads; Sartori, Igor

    2008-07-01

    The National Office of Building Technology and Administration (BE) desired to review the consequences of different levels of ambition for requirements for heat gaining from vent air, as well as a possible requirement for energy efficient design of building fronts. In addition the energy scope in the regulation (TEK2007) should be adjusted according to the final establishment of a new calculation standard (Norwegian Standard - NS 3031:2007). A statement on these subjects has been carried out at SINTEF Byggforsk, and is described in this report. Adjustments of framework regulations.There are only minor differences between adjusted calculations according to NS 3031 and the original energy framework calculations, i.e. the difference for net energy need amounts to the size of 0 to 6 percent. Heat gain.The report shows that it is possible - both from techical and financial considerations - to increase the requirement level for heat gain from vent air for most categories of buildings. This implies a sharpening of the annual median temperature efficiency from 70 % to 80 %, for all building categories, except from hospitals, institutions and light industry/workshops. A possible sharpening of regulations for heat gain in houses has not been evaluated. Depending on building category a sharpening of regulations for heat gain from vent air will imply that net energy need will be reduced on a scale of 20 to 30 kWh/m2 per annum. The report demonstrates that despite a possible sharpening of the requirements on energy efficiency for heat recovery devices does not prevent the use of large areas of windows and window panes. Vulnerability analyses show that deviations from the prerequisites in the basis for the energy framework concerning air quantities and air temperatures give the possibility of weakening the building's heating characteristics. Building fronts. Different methods for added requirements for building fronts have been examined. The aim has been to find methods and

  16. Clean Water Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data represent geographic terms used within the Clean Water Act (CWA). The CWA establishes the basic structure for regulating the addition of pollutants...

  17. βENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension.

    Science.gov (United States)

    Drummond, Heather A; Stec, David E

    2015-06-01

    Pressure-induced constriction (also known as the "myogenic response") is an important mechanodependent response in small renal arteries and arterioles. The response is initiated by vascular smooth muscle cell (VSMC) stretch due to an increase in intraluminal pressure and leads to vasoconstriction. The myogenic response has two important roles as a mechanism of local blood flow autoregulation and protection against systemic blood pressure-induced microvascular damage. However, the molecular mechanisms underlying initiation of myogenic response are unresolved. Although several molecules have been considered initiators of the response, our laboratory has focused on the role of degenerin proteins because of their strong evolutionary link to mechanosensing in the nematode. Our laboratory has addressed the hypothesis that certain degenerin proteins act as mechanosensors in VSMCs. This article discusses the importance of a specific degenerin protein, β Epithelial Na + Channel (βENaC), in pressure-induced vasoconstriction, renal blood flow and susceptibility to renal injury. We propose that loss of the renal myogenic constrictor response delays the correction of renal blood flow that occurs with fluctuations in systemic pressure, which allows pressure swings to be transmitted to the microvasculature, thus increasing the susceptibility to renal injury and hypertension. The role of βENaC in myogenic regulation is independent of tubular βENaC and thus represents a non-tubular role for βENaC in renal-cardiovascular homeostasis.

  18. O debate sobre a regulamentação do ato médico no Brasil The debate about the regulation of the medical act in Brazil

    Directory of Open Access Journals (Sweden)

    Regina Guedes Moreira Guimarães

    2005-12-01

    Full Text Available Este artigo discute a demanda pela regulamentação do "ato médico" no Brasil à luz do referencial teórico da Sociologia das profissões. Apresenta e analisa os principais argumentos trazidos pelas corporações ao debate político a partir de documentos oficiais e entrevistas dos principais atores, entendendo o processo como legítima busca de defesa das prerrogativas e privilégios corporativos. Reconhecendo que a disputa está relacionada à construção das identidades profissionais, defende a regulamentação das profissões da área da saúde respeitando-se suas competências e habilidades teóricas e práticas. Conclui enfatizando que o papel do Estado na regulamentação das profissões precisa considerar os interesses da sociedade diante da intensa divisão do trabalho ocorrida na área da saúde, respeitando-se as competências exclusivas da medicina e reconhecendo as das novas profissões da área, como fisioterapia, fonoaudiologia, psicologia e outras.This article discusses the demand for the regulation of the "medical act" in Brazil considering the theoretical framework adopted by the sociology of the professions. It presents and analyzes the main arguments of the health corporations based in official documents and main actors' interviews. The process is understood as a legitimate action of defense of the prerogatives and corporate privileges. Recognizing that the dispute is related to the construction of the professional identities it defends that the regulation of the health professions must respect their competences and theoretical and practical abilities. It concludes emphasizing that the role of the State in the regulation of the professions must consider the interests of the society in face of the intense technical division of the work that happened in the health sector. This means to respect the exclusive competences of the medicine and recognize those of the new professions of the area, such as physiotherapy

  19. 7 CFR 65.100 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Act. 65.100 Section 65.100 Agriculture Regulations of... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING OF BEEF..., AND GINSENG General Provisions Definitions § 65.100 Act. Act means the Agricultural Marketing Act of...

  20. Radioactive Substances Act 1960

    International Nuclear Information System (INIS)

    1960-01-01

    This Act regulates the keeping and use of radioactive material and makes provision for the disposal and storage of radioactive waste in the United Kingdom. It provides for a licensing system for such activities and for exemptions therefrom, in particular as concerns the United Kingdom Atomic Energy Authority. The Act repeals Section 4(5) of the Atomic Energy Authority Act, 1954 which made temporary provision for discharge of waste on or from premises occupied by the Authority. (NEA) [fr

  1. Americans with Disabilities Act.

    Science.gov (United States)

    Kaesberg, Mary Ann; Murray, Kenneth T.

    1994-01-01

    Presents a 35-item checklist of practical activities for school district compliance with the Americans with Disabilities Act (ADA). The checklist is based on ADA statutes, other civil rights legislation and litigation, as well as pertinent regulations and the legislative history of the act contained in the Congressional Record. (MLF)

  2. Radiation emitting devices regulations

    International Nuclear Information System (INIS)

    1970-01-01

    The Radiation Emitting Devices Regulations are the regulations referred to in the Radiation Emitting Devices Act and relate to the operation of devices. They include standards of design and construction, standards of functioning, warning symbol specifications in addition to information relating to the seizure and detention of machines failing to comply with the regulations. The radiation emitting devices consist of the following: television receivers, extra-oral dental x-ray equipment, microwave ovens, baggage inspection x-ray devices, demonstration--type gas discharge devices, photofluorographic x-ray equipment, laser scanners, demonstration lasers, low energy electron microscopes, high intensity mercury vapour discharge lamps, sunlamps, diagnostic x-ray equipment, ultrasound therapy devices, x-ray diffraction equipment, cabinet x-ray equipment and therapeutic x-ray equipment

  3. "Current Good Manufacturing Practices" and the Federal Food, Drug and Cosmetic Act

    OpenAIRE

    Goldstein, Beth F.

    1995-01-01

    The Food and Drug Administration (hereinafter, FDA) regulates food, drugs, and cosmetics in order to ensure that these products are safe and truthfully labelled. As part of its responsibilities under the Federal Food, Drug, and Cosmetic Act (hereinafter, Act), the FDA monitors the manufacturing practices of companies involved in the production of food, drugs, and medical devices. The manufacturing practices used by these companies must comply with certain standards, identified in the Act as "...

  4. 16 CFR 1611.37 - Reasonable and representative tests under section 8 of the Act.

    Science.gov (United States)

    2010-01-01

    ... FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY OF VINYL PLASTIC FILM Rules and Regulations... textile fabric weighing less than two ounces per square yard, such fabric exhibits a burning time of 3.5... fabric ignites but the flame is extinguished before the stop cord is burned, such test may suffice for...

  5. Wireless installation standard

    International Nuclear Information System (INIS)

    Lim, Hwang Bin

    2007-12-01

    This is divided six parts which are radio regulation law on securing of radio resource, use of radio resource, protection of radio resource, radio regulation enforcement ordinance with securing, distribution and assignment of radio regulation, radio regulation enforcement regulation on utility of radio resource and technical qualification examination, a wireless installation regulation of technique standard and safety facility standard, radio regulation such as certification regulation of information communicative machines and regulation of radio station on compliance of signal security, radio equipment in radio station, standard frequency station and emergency communication.

  6. The FDA Food Safety and Modernization Act and the Exemption for Small Firms

    OpenAIRE

    Pouliot, Sebastien

    2011-01-01

    The FDA Food Safety Modernization Act of 2010 is new legislation that mandates, among other things, new food safety standards. The act includes a clause that exempts small firms from new regulatory requirements. This paper investigates the effects of a small firm exemption from more stringent food safety standards. The model compares food safety, total output and the number of market participants for different food safety regulation with and without an exemption for small firms. The numerical...

  7. 12 CFR 1401.1 - Cross-references to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Cross-references to employee ethical conduct... INSURANCE CORPORATION EMPLOYEE RESPONSIBILITIES AND CONDUCT § 1401.1 Cross-references to employee ethical... the Farm Credit System Insurance Corporation are subject to the Standards of Ethical Conduct for...

  8. 22 CFR 1001.1 - Cross-references to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cross-references to employee ethical conduct... FOUNDATION EMPLOYEE RESPONSIBILITIES AND CONDUCT § 1001.1 Cross-references to employee ethical conduct... Foundation should refer to the Standards of Ethical Conduct for Employees of the Executive Branch at 5 CFR...

  9. 22 CFR 1504.1 - Cross-references to employee ethical conduct standards and financial disclosure regulations.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Cross-references to employee ethical conduct... FOUNDATION EMPLOYEE RESPONSIBILITIES AND CONDUCT § 1504.1 Cross-references to employee ethical conduct... Foundation are subject to the Standards of Ethical Conduct for Employees of the Executive Branch at 5 CFR...

  10. Food processor and retailer non-GMO standards in the US and EU and the driving role of regulations

    NARCIS (Netherlands)

    Castellari, Elena; Soregaroli, Claudio; Venus, Thomas J.; Wesseler, Justus

    2018-01-01

    In the last two decades, voluntary standards have played an increasing role in reshaping the non-GMO labeling schemes in the EU and the US. This work compares the mandatory and voluntary labeling schemes for food produced from or with GMO in these two markets. After reviewing the EU and US

  11. Current situation on regulations for mycotoxins. Overview of tolerances and status of standard methods of sampling and analysis.

    Science.gov (United States)

    Van Egmond, H P

    1989-01-01

    A worldwide enquiry was undertaken in 1986-1987 to obtain up-to-date information about mycotoxin legislation in as many countries of the world as possible. Together with some additional data collected in 1981, information is now available about planned, proposed, existing or absence of legislation in 66 countries. Details about tolerances, legal bases, responsible authorities, prescribed methods of sampling and analysis and disposition of commodities containing inadmissible amounts of mycotoxins, are given. The information concerns aflatoxins in foodstuffs, aflatoxin M1 in dairy products, aflatoxins in animal feedstuffs, and other mycotoxins in food- and feedstuffs. In comparison with the situation in 1981, limits and regulations for mycotoxins have been expanded in 1987 with more countries having legislation (proposed or passed) on the subject, more products, and more mycotoxins covered by this legislation. The differences between tolerances in the various countries are sometimes quite large, which makes harmonization of mycotoxin regulations highly desirable.

  12. Radiation emitting devices act

    International Nuclear Information System (INIS)

    1970-01-01

    This Act, entitled the Radiation Emitting Devices Act, is concerned with the sale and importation of radiation emitting devices. Laws relating to the sale, lease or import, labelling, advertising, packaging, safety standards and inspection of these devices are listed as well as penalties for any person who is convicted of breaking these laws

  13. Identification and molecular characterization of a trans-acting small interfering RNA producing locus regulating leaf rust responsive gene expression in wheat (Triticum aestivum L.).

    Science.gov (United States)

    Dutta, Summi; Kumar, Dhananjay; Jha, Shailendra; Prabhu, Kumble Vinod; Kumar, Manish; Mukhopadhyay, Kunal

    2017-11-01

    A novel leaf rust responsive ta-siRNA-producing locus was identified in wheat showing similarity to 28S rRNA and generated four differentially expressing ta-siRNAs by phasing which targeted stress responsive genes. Trans-acting-small interfering RNAs (Ta-siRNAs) are plant specific molecules generally involved in development and are also stress responsive. Ta-siRNAs identified in wheat till date are all responsive to abiotic stress only. Wheat cultivation is severely affected by rusts and leaf rust particularly affects grain filling. This study reports a novel ta-siRNA producing locus (TAS) in wheat which is a segment of 28S ribosomal RNA but shows differential expression during leaf rust infestation. Four small RNA libraries prepared from wheat Near Isogenic Lines were treated with leaf rust pathogen and compared with untreated controls. A TAS with the ability to generate four ta-siRNAs by phasing events was identified along with the microRNA TamiR16 as the phase initiator. The targets of the ta-siRNAs included α-gliadin, leucine rich repeat, trans-membrane proteins, glutathione-S-transferase, and fatty acid desaturase among others, which are either stress responsive genes or are essential for normal growth and development of plants. Expression of the TAS, its generated ta-siRNAs, and their target genes were profiled at five different time points after pathogen inoculation of susceptible and resistant wheat isolines and compared with mock-inoculated controls. Comparative analysis of expression unveiled differential and reciprocal relationship as well as discrete patterns between susceptible and resistant isolines. The expression profiles of the target genes of the identified ta-siRNAs advocate more towards effector triggered susceptibility favouring pathogenesis. The study helps in discerning the functions of wheat genes regulated by ta-siRNAs in response to leaf rust.

  14. Privacy Act

    Science.gov (United States)

    Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

  15. Radioactive Substances Act 1948

    International Nuclear Information System (INIS)

    1948-01-01

    This Act regulates the use of radioactive substances and radiation producing devices in the United Kingdom. It provides for the control of import, export, sale, supply etc. of such substances and devices and lays down the safety regulations to be complied with when dealing with them. (NEA) [fr

  16. The Radiation Protection Act

    International Nuclear Information System (INIS)

    Persson, L.

    1989-01-01

    The new Radiation Protection Act (1988:220) entered into force in Sweden on July 1st, 1988. This book presents the Act as well as certain regulations connected to it. As previously, the main responsibility for public radiation protection will rest with one central radiation protection authority. According to the 1988 Act, the general obligations with regard to radiation protection will place a greater responsibility than in the past on persons carrying out activities involving radiation. Under the act, it is possible to adjust the licensing and supervisory procedures to the level of danger of the radiation source and the need for adequate competence, etc. The Act recognises standardised approval procedures combined with technical regulations for areas where the risks are well known. The Act contains several rules providing for more effective supervision. The supervising authority may in particular decide on the necessary regulations and prohibitions for each individual case. The possibilities of using penal provisions have been extended and a rule on the mandatory execution of orders has been introduced. The Ordinance on Radiation Protection (1988:293) designates the National Institute of Radiation Protection (SSI) as the central authority referred to in the Radiation Protection Act. The book also gives a historic review of radiation protection laws in Sweden, lists regulations issued by SSI and presents explanations of radiation effects and international norms in the area. (author)

  17. 7 CFR 54.1034 - OMB control numbers assigned pursuant to the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS..., Processing, and Packaging of Livestock and Poultry Products § 54.1034 OMB control numbers assigned pursuant...

  18. 7 CFR 985.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 985.2 Section 985.2 Agriculture Regulations of... SPEARMINT OIL PRODUCED IN THE FAR WEST Order Regulating Handling Definitions § 985.2 Act. Act means Public Act No. 10, 73d Congress, as amended, and reenacted and amended by the Agricultural Marketing...

  19. 7 CFR 924.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 924.2 Section 924.2 Agriculture Regulations of... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as re-enacted and amended by the Agricultural...

  20. 7 CFR 958.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 958.2 Section 958.2 Agriculture Regulations of... IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 958.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing...

  1. 7 CFR 945.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 945.2 Section 945.2 Agriculture Regulations of... COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 945.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing...

  2. Endogenous 4-hydroxy-2-nonenal in microalga Chlorella kessleri acts as a bioactive indicator of pollution with common herbicides and growth regulating factor of hormesis.

    Science.gov (United States)

    Spoljaric, Dubravka; Cipak, Ana; Horvatic, Janja; Andrisic, Luka; Waeg, Georg; Zarkovic, Neven; Jaganjac, Morana

    2011-10-01

    Oxidative stress, i.e. excessive production of reactive oxygen species (ROS), leads to lipid peroxidation and to formation of reactive aldehydes (e.g. 4-hydroxy-2-nonenal; HNE), which act as second messengers of free radicals. It was previously shown that herbicides can induce ROS production in algal cells. In the current paper, the unicellular green microalga Chlorella kessleri was used to study the effect of two herbicides (S-metolachlor and terbuthylazine) and hydrogen peroxide (H(2)O(2)) on oxidative stress induction, HNE formation, chlorophyll content and the cell growth. Production of HNE was detected in this study for the first time in the cells of unicellular green algae using the antibody specific for the HNE-histidine adducts revealing the HNE-histidine adducts even in untreated, control C. kessleri. Exposure of algal cells to herbicides and H(2)O(2) increased the ROS production, modifying production of HNE. Namely, 4h upon treatment the levels of HNE-histidine conjugates were below controls. However, their amount increased afterwards. The increase of HNE levels in algae was followed by their increased growth rate, as was previously described for human carcinoma cells. Hence, changes in the cellular HNE content upon herbicide treatment inducing lipid oxidative stress and alterations in cellular growth rate of C. kessleri resemble adaptation of malignant cells to the HNE treatment. Therefore, as an addition to the standard toxicity tests, the evaluation of HNE-protein adducts in C. kessleri might indicate environmental pollution with lipid peroxidation-inducing herbicides. Finally, C. kessleri might be a convenient experimental model to further study cellular hormetic adaptation to oxidative stress-derived aldehydes. Copyright © 2011 Elsevier B.V. All rights reserved.

  3. Laws, Regulations, Guidelines and Standards for Animal Care and Use for Scientific Purposes in the Countries of Singapore, Thailand, Indonesia, Malaysia, and India.

    Science.gov (United States)

    Retnam, Leslie; Chatikavanij, Pradon; Kunjara, Pattamarat; Paramastri, Yasmina A; Goh, Yong Meng; Hussein, Fuzina Nor; Mutalib, Abdul Rahim; Poosala, Suresh

    2016-05-01

    The laws, regulations, guidelines, and standards on animal care and use for scientific purposes in the countries of Singapore, Thailand, Indonesia, and Malaysia, and India are described in this manuscript. For each of these five countries, a brief introduction is provided on the history of how the need for animal welfare in research, education, training, and testing came to being. This is followed by some background information leading to the current status of regulations and guidelines in each of the five countries. There is also a description of the responsibilities and functions of institutional animal welfare and ethics oversight bodies, enforcement agencies, penalties, and organizations supporting the industry. Finally, a conclusion with insights into the future of laboratory animal welfare and science in each of these five countries in Asia is provided. © The Author 2017. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  4. Regulating nuclear fuel waste

    International Nuclear Information System (INIS)

    1995-01-01

    When Parliament passed the Atomic Energy Control Act in 1946, it erected the framework for nuclear safety in Canada. Under the Act, the government created the Atomic Energy Control Board and gave it the authority to make and enforce regulations governing every aspect of nuclear power production and use in this country. The Act gives the Control Board the flexibility to amend its regulations to adapt to changes in technology, health and safety standards, co-operative agreements with provincial agencies and policy regarding trade in nuclear materials. This flexibility has allowed the Control Board to successfully regulate the nuclear industry for more than 40 years. Its mission statement 'to ensure that the use of nuclear energy in Canada does not pose undue risk to health, safety, security and the environment' concisely states the Control Board's primary objective. The Atomic Energy Control Board regulates all aspects of nuclear energy in Canada to ensure there is no undue risk to health, safety, security or the environment. It does this through a multi-stage licensing process

  5. Canada's Assisted Human Reproductive Act: is it scientific censorship, or a reasoned approach to the regulation of rapidly emerging reproductive technologies?

    Science.gov (United States)

    Rasmussen, Colin

    2004-01-01

    After more than a decade of study, discussion and debate, the Canadian House of Commons and Senate have approved the Assisted Human Reproduction Act. Building on the earlier Bill C-47, which died on the order paper in 1997, the Act bans human cloning for reproductive or therapeutic purposes, payment for surrogacy arrangements, and trading in human reproductive materials or their use without informed consent. In addition, the Act significantly restricts research using human reproductive materials. This article compares the Act to legislative regimes in other nations with advanced human reproductive science. It concludes that while the Act has many laudable goals, it is flawed in that it tries to cover too much legislative ground. As a result it unreasonable impairs the ability of Canadian scientists to compete in areas such as stem cell research, and area that is expected to yield significant new approaches to treating human disease.

  6. 78 FR 3843 - Federal Motor Vehicle Safety Standards; New Pneumatic and Certain Specialty Tires

    Science.gov (United States)

    2013-01-17

    ... Approval Handbook for Japanese Certification, Safety Regulations for Road Vehicles, Technical Standards For... Technology Transfer and Advancement Act Section 12(d) of the National Technology Transfer and Advancement Act... vehicle safety, Motor vehicles, Rubber and rubber products, and Tires. In consideration of the foregoing...

  7. Calibrating Fundamental British Values: How Head Teachers Are Approaching Appraisal in the Light of the Teachers' Standards 2012, Prevent and the Counter-Terrorism and Security Act, 2015

    Science.gov (United States)

    Revell, Lynn; Bryan, Hazel

    2016-01-01

    In requiring that teachers should "not undermine fundamental British values (FBV)," a phrase originally articulated in the Home Office counter-terrorism document, Prevent, the Teachers' Standards has brought into focus the nature of teacher professionalism. Teachers in England are now required to promote FBV within and outside school,…

  8. The ACT/NAGB Standard Setting Process: How "Modified" Does It Have To Be before It Is No Longer a Modified-Angoff Process?

    Science.gov (United States)

    Reckase, Mark D.

    The kernel of the Angoff method of standard setting (W. Angoff, 1971) would seem to be the judgment of whether a minimally competent person could answer an item on a test correctly or not. So it would seem that any procedure that requires independent judgment of the correctness or incorrectness of a response to items for a minimally acceptable…

  9. 29 CFR 4.2 - Payment of minimum wage specified in section 6(a)(1) of the Fair Labor Standards Act of 1938...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Payment of minimum wage specified in section 6(a)(1) of the... and Procedures § 4.2 Payment of minimum wage specified in section 6(a)(1) of the Fair Labor Standards... employees shall pay any employees engaged in such work less than the minimum wage specified in section 6(a...

  10. Evaluating the U.S. Food Safety Modernization Act Produce Safety Rule Standard for Microbial Quality of Agricultural Water for Growing Produce

    NARCIS (Netherlands)

    Havelaar, Arie H; Vazquez, Kathleen M; Topalcengiz, Zeynal; Muñoz-Carpena, Rafael; Danyluk, Michelle D

    2017-01-01

    The U.S. Food and Drug Administration (FDA) has defined standards for the microbial quality of agricultural surface water used for irrigation. According to the FDA produce safety rule (PSR), a microbial water quality profile requires analysis of a minimum of 20 samples for Escherichia coli over 2 to

  11. 7 CFR 956.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 956.2 Section 956.2 Agriculture Regulations of... OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Definitions § 956.2 Act. Act means Public Act No. 10... Agreement Act of 1937, as amended (Sec. 1-19, 48 Stat. 31, as amended; 7 U.S.C. 601 et seq.). ...

  12. 7 CFR 983.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 983.2 Section 983.2 Agriculture Regulations of... NEW MEXICO Definitions § 983.2 Act. Act means Public Act No. 10, 73rd Congress (May 12, 1933), as amended and as re-enacted and amended by the Agricultural Marketing Order Act of 1937, as amended (48 Stat...

  13. 7 CFR 930.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 930.1 Section 930.1 Agriculture Regulations of... Definitions § 930.1 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended, and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as...

  14. 7 CFR 984.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 984.2 Section 984.2 Agriculture Regulations of... Handling Definitions § 984.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (7 U.S.C. 601 et seq.). ...

  15. 7 CFR 925.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 925.2 Section 925.2 Agriculture Regulations of... SOUTHEASTERN CALIFORNIA Definitions § 925.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48...

  16. 7 CFR 959.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 959.2 Section 959.2 Agriculture Regulations of... Handling Definitions § 959.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (sections 1-19, 48 Stat...

  17. 7 CFR 932.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 932.2 Section 932.2 Agriculture Regulations of... Handling Definitions § 932.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933) as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31...

  18. 7 CFR 981.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 981.2 Section 981.2 Agriculture Regulations of... Handling Definitions § 981.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as amended...

  19. 7 CFR 966.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 966.2 Section 966.2 Agriculture Regulations of... Handling Definitions § 966.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as amended...

  20. 7 CFR 1170.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Act. 1170.2 Section 1170.2 Agriculture Regulations of... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act of...