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Sample records for acos api 5l

  1. Study of API 5L X70 steel corrosion processes when in contact with some Brazilian soils; Estudo dos processos de corrosao de acos API 5L X70 em contato com alguns dos solos do Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Jesus, Sergio Luis de

    2007-07-01

    Pipelines, fuel storage tanks and other metallic structures are in permanent contact and exposed to different types of soils, of horizons or layers, or of soil aggressiveness. This interaction may cause expressive damages to the environment and to the planned work. Contamination may occur due to leakage of stored products, splitting during transportation, accidents caused by pipelines without extensive maintenance. The result of these accidents could be, among others, some financial losses. In order to recognize the dynamic interactions between metallic surfaces and the environment it is crucial to have preventive actions and to develop better-applied materials. API steel 5L X70 has been used in structures of low and high pressure with high mechanical strength and corrosion and, even so, it is susceptible to etching corrosion since it is in contact with different environments from mangrove regions to industrial environments. The present case evaluated the role of 5L X70 API steel in contact with different soil horizons representative of the Brazilian soil. This investigation correlated chemical species with solute ions in soil solution, secondary and primary phase minerals besides physical and chemical characteristics as pH, electric conductivity, total dissolved solids, among others, to the results of corrosion resistance and ways of corrosion. The evaluation was carried out using x-ray diffractometry, scanning electron microscopy, total reflection x-ray fluorescence, fuel injection flow besides texture and gravimetric analyses to soil characterization and mineralogy, identification of corrosion products, soil solution analyses, evaluation of tested materials and classification of ways and types of corrosion. This was an attempt to integrate the data to a better understanding of the process involving reagents and products. The results showed that different soil horizons such as different types of analyzed soils produce specific etching in metallic structures

  2. Development of API 5L X70 and X80 in the Brazilian Vallourec and Mannesmann Tubes industry; Desenvolvimento de acos API 5L X70 e X80 na Vallourec e Mannesmann Tubes

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Julio M. Silveira e; Carvalho, Ricardo N. de [Vallourec and Mannesmann Tubes - V e M do Brasil, Belo Horizonte, MG (Brazil)

    2000-07-01

    The demand for seamless pipes with resistance higher than those for API 5L X60 and X65 grades has increased in the last years. They are traditionally used up to now for applications on rigid risers for production and exportation and line pipes for oil and gas. In the case of seamless pipes, the great challenge is to fulfill the requirements of mechanical properties for X70 and X80 grades, quenched and tempered, with values of carbon equivalent low enough to assure a good weldability. This paper presents the results obtained by Vallourec and Mannesmann Tubes - V and M do Brazil on producing seamless pipes of X70 and X80 API grades, with outside diameter lower than 8 5/8{sup (} 219,1 mm ) and wall thickness up to 0,562{sup (} 14,3 mm ). Results of tensile, Charpy notch impact resistance and hardness tests are shown. Hydrogen-Induced and Environmental Cracking tests were also carried out, since for some applications is required a good resistance to these kinds of embrittlement mechanisms. The mechanical properties, microstructure and physical characteristics of welded joints were also evaluated. The results obtained up to now are quite promising, showing good suitability to the aimed final applications. (author)

  3. Hardness and microstructural characterization of API 5L X70 steel pipes welded by HF/ERW process; Caracterizacao microestrutural e de dureza em tubos de aco API 5L X70 soldados pelo processo HF/ERW

    Energy Technology Data Exchange (ETDEWEB)

    Calcada, Mauricio Vieira; Voorwald, Herman Jacobus Cornelis; Nascimento, Marcelino Pereira do [UNESP, Guaratingueta, SP (Brazil). Faculdade de Engenharia

    2010-07-01

    The materials that stand in the manufacture of steel pipes are called API, that should have, high mechanical resistance, high corrosion resistance, high fatigue resistance, good weldability, and other properties. Thus, the purpose of this project was to evaluate the microstructure and hardness of welded joints by the HF/ERW process of API 5L X70 steel pipes. The microstructural analysis was performed using a surface finish with grit sizes from 220 to 25 {mu}m e polishing with diamond paste from 9 {mu}m to 0.05 {mu}m; the revelation was made with 3% Nital attack. The Vickers hardness was performed across the welded joint by 33 points to indentation. The results were: 80.5 {+-} 3.4% of ferrite and 19.5 {+-} 3.4% of perlite for microanalysis. As for hardness, the values were: 215.69 HV10 for weld line, 218.65 HV10 for ZTA and 218.95 HV10 for base metal. (author)

  4. Obtaining and analysis of results of fatigue and corrosion-fatigue in steel API 5L X60; Obtencao e analise de resultados de fadiga e corrosao-fadiga em aco API 5L X60

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Bruno Allison [Universidade Federal de Campina Grande (UFCG), PB (Brazil). Programa de Pos-Graduacao em Ciencia e Engenharia de Materiais; Silva, Antonio Almeida; Santos, Fabio Gualberto Chagas [Universidade Federal de Campina Grande (UFCG), PB (Brazil)

    2008-07-01

    The corrosion process allied to the fatigue, due to repetitive efforts of several natures, is the main responsible for the damages in pipeline and offshore structures that results in the appears of located faults, and by the way can results in leaks and financial and environmental loss. This phenomenon calls corrosion-fatigue, however, it is very complex, and mainly, in what it concerns the form as this it develops in the structure. The objective of this work is to present some results of experimental fatigue tests and corrosion-fatigue accomplished with specimen that the material originated a pipeline steel API 5L X60. The tests developed in a machine which could test until 12 specimens per time. For test of corrosion-fatigue was used a cell-of-corrosion especially projected, in this way simulated an aggressive environmental condition in a corrosion conditions. With the results of tests, was possible estimate the fatigue limits of the specimen when submitted to the repeated flexing, and compare it with evaluate corrosion-fatigue graphs, that as the literature comes moved down of the curve, in relation to the fatigue curve. (author)

  5. Effect of the welding process on the microstructure and microhardness of API 5L X80 steel welded joint used for oil transportation pipeline; Efeito do processo de soldagem sobre a microestrutura e a microdureza de juntas soldadas de aco API 5L X80 usado em tubulacoes para transporte de petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Alves, R.T.P.; Albuquerque, S.F. [Universidade Federal de Campina Grande (UFCG), PB (Brazil); Maciel, T.M.; Almeida, D.M.; Santos, M.A.

    2008-07-01

    This study had as objective to evaluate the microstructure and microhardness of API 5L X80 steel welded joints, used for pipelines to transport oil and gas, using the Shield Metal Arc Welding process with pre- heating temperature of 200 deg C and 400 deg C and the AWS E8010G electrode as filler metal. For this, besides the microhardness of the welded joint, the weld metals percentiles of micro-constituents and of columnar and regenerated grains and the medium size and extension of the heat affected zone were evaluated. The percentage of acicular ferrite in weld metal ranged from 13% to 33% which generated values of microhardness from 114 HV to 309 HV. (author)

  6. Construction and assembly of pipelines using API 5L grade X80 tubes - considerations to be observed with high-strength steels; Construcao e montagem de dutos terrestres utilizando tubos API 5L Gr. X80

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Ailton C. de; Rabello, Jose Mauricio B. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

    2005-07-01

    The use of line pipes API 5L Grade X80, at the point of view of designer allows: reduction of wall thickness and pipe weight or increase of design pressure. In the pipeline construction point of view, the use of line pipes API 5L Grade X80 provide some advantages, however some difficulties must be expected in several stages of the construction and assembly. The implications in cost, productivity, inspection and integrity, with the application of these high resistance steels, complying with PETROBRAS Standard N - 464 Construcao, Montagem e Condicionamento de Dutos Terrestres (Rev. H - 2004 Dec) and the experience consolidated in pipelines construction abroad were presented. At the design stage, a comparison between pipelines designed using API 5L-X70 and API 5L-X80 was carried out approaching the aspects of variation of thickness, pressure design and design factor. An evaluation of the expected gains when choosing API 5L Grade X80 steels were done, regarding reduction of costs and pipe weight. Regarding API 5L-X80 pipe fabrication, the obtained results were reported, proving that this aspect was already overcome, showing the viability of its production in Brazil. Difficulties were detected regarding construction and assembly stage and showing the need of revision of PETROBRAS standard N-464. (author)

  7. API Spec5L(44版)关于材料及试验的变化%Changes of Materials and Tests in 44th Edition of Standard API Spec 5L

    Institute of Scientific and Technical Information of China (English)

    王德林; 同建辉; 孙宏; 崔明亮

    2011-01-01

    针对API Spec 5L(44版)标准,简要分析了API 5L(44版)标准对于材料与理化试验方面与前一版本的变化.新版API 5L标准相比以前版本更加精简,实际使用更方便,在理化试验方面细节上变化较大,在焊管的实际生产应用中应予以注意.

  8. Determination of acoustoelastic constant in API-5L-X70 welded pipes; Determinacao da constante acustoelastica de tubos API-5L-X70 com solda

    Energy Technology Data Exchange (ETDEWEB)

    Bittencourt, Marcelo de Siqueira Queiroz; Fonseca, Manoel Antonio da Costa [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Oliveira, Carlos Henrique Francisco de [PETROBRAS S.A., Rio de de Janeiro, RJ (Brazil)

    2008-07-01

    To preserve the environment and avoid financial losses resulting from leaks in the transport of natural oil and gas the industry is particularly concerned to ensure the structural integrity of their pipelines. Grounded pipes may be exposed to damages due to unstable soil movement, and in extreme cases, to failure. Then, techniques to assess stress in pipelines are of central importance. The ultrasonic birefringence technique is an efficient method to measure residual stress. It is based on the changing velocity of the shear wave when it crosses a material under stress; this phenomenon is known as acoustoelasticity. The knowledge of the parameter called acoustoelastic constant is necessary to measure stress using this technique. By the mechanical conformation in the manufacture of welded tubes, from rolled plates, different anisotropy degrees are showed around the cross section of these tubes. In this paper it was studied the acoustoelastic constant for the API-5L-X70 steel pipes, with different thicknesses, diameters and manufacturing processes so as to be able to use this technique to stress measurement in pipelines. (author)

  9. Microbial Corrosion of API 5L X-70 Carbon Steel by ATCC 7757 and Consortium of Sulfate-Reducing Bacteria

    OpenAIRE

    2014-01-01

    Various cases of accidents involving microbiology influenced corrosion (MIC) were reported by the oil and gas industry. Sulfate reducing bacteria (SRB) have always been linked to MIC mechanisms as one of the major causes of localized corrosion problems. In this study, SRB colonies were isolated from the soil in suspected areas near the natural gas transmission pipeline in Malaysia. The effects of ATCC 7757 and consortium of isolated SRB upon corrosion on API 5L X-70 carbon steel coupon were i...

  10. Study of phase transformations In API 5L X80 Steel in order to increase its fracture toughness

    OpenAIRE

    Igor Rafael Vilarouco Pedrosa; Renato Soares de Castro; Yogendra Prasad Yadava; Ricardo Artur Sanguinetti Ferreira

    2013-01-01

    Phase transformations in API 5L X80 steel were studied in different thermomechanical sequences with a view to increasing the fracture toughness of this steel. Dilatometry tests performed on the quenched steel detected a phase transformation occurred, during heating, in the temperature range 593-618 K. This phase transformation was identified as the dissolution of M-A islands. Based on preliminary dilatometric tests, ten thermal and thermomechanical treatments were performed on X80 steel sampl...

  11. Development of high strength pipes grade API 5L X70 PSL2 offshore by the HFIW Process (High Frequency Induction Welding)

    Energy Technology Data Exchange (ETDEWEB)

    Cordeiro, Wilson R.; Melo, Luis C.R.; Gomes, Igor O.; Boni, Luiz P.; Sanctis, Marco A.M. di [Apolo Tubulars, Lorena, SP (Brazil)

    2009-07-01

    High strength pipes can be manufactured with excellency in dimensional tolerances, rapidity and efficiency through HFIW process (High Frequency Induction Welding). API 5L 6 5/8 x 0,374 in pipes were made of thin, hot rolled and coiled plates with dimensional 9,300 x 1.040,0 x 140.000 mm. Mechanical tests, chemical and microstructural analysis were performed. For the microstructural analysis, ferrite and perlitic structure were detected. All the results obtained are according to API 5L, 44{sup th} edition, 2008 for the grade API 5L X70 PSL2 Offshore. (author)

  12. API RP 5 L3-2014输送钢管落锤撕裂试验推荐做法简介%Introduction of Drop-Weight Tear Tests on Line Pipe Recommended Practice API RP 5 L3-2014

    Institute of Scientific and Technical Information of China (English)

    孙宏

    2016-01-01

    介绍了新版的落锤撕裂试验(DWTT)的试验标准API RP 5L3-2014《输送钢管落锤撕裂试验推荐做法》,并与以前的版本API RP 5L3-1996进行了比较。对比发现新版的API RP 5L3-2014《输送钢管落锤撕裂试验推荐做法》仍然延续了API RP 5L3-1996的主要技术内容,并与国内的常用的SY/T 6476-2013和GB/T8363-2007仍然有一定差异。%The latest edition of Drop-Weight Tear Tests on Line Pipe Recommended Practice API RP 5L3-2014 was introduced compared with the last edition API RP 5L3-1996. It is found that the latest edition of API RP 5L3 still continues containing more technical content in the API RP 5L3-1996, but it is apparently different with SY/T 6476-2013 and GB/T 8363-2007, which are mainly used domestically.

  13. API 5L X80 PSL2 pipes manufactured by ERW process: TenarisConfab and USIMINAS development; Tubos API 5L X80 PSL2 processados por ERW: desenvolvimento TenarisConfab-Usiminas

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Ronaldo C.; Roza, Juliana E.; Kojima, Sergio S. [TenarisConfab, Pindamonhangaba, SP (Brazil); Miranda, Lucio S.; Turani, Leonardo O. [USIMINAS, Ipatinga, MG (Brazil)

    2005-07-01

    The utilization of high strength steels can decrease, both, installation and operation costs of a new pipeline, since the increase of mechanical resistance can reduce the pipe wall thickness and, consequently, the weight of the pipe. For this purpose, the manufacture of electric resistance welding (ERW) pipes is recent, and it comes as an opportunity for gas pipelines, mainly onshore projects. As a function of their larger productivity, ERW pipes are more economically attractive than those produced by seamless and SAW processes. TenarisConfab and USIMINAS, through studies and investments in manufacturing processes, have been working to increase their skills, in order to supply ERW pipes in API 5L X80 PSL2 steel. The steel elaborated by USIMINAS is low C, high Mn, Nb, V and Ti microalloyed, and with additions of Cr and Mo, aiming to produce hot rolled coils with acicular microstructure, achieved as a combination between its chemical composition and higher cooling rates after hot rolling. The results in {phi}18''(457 mm) x 0,469''(11,91 mm) pipes are presented in this article. High toughness values reached at very low temperatures suggest that ERW API 5L X80 PSL2 pipes developed by TenarisConfab and USIMINAS may be an excellent option of choice for onshore projects that request pipes in diameters up to 20''(508 mm) and thickness up to 0,500'' (12,7 mm). (author)

  14. Corrosion resistance of ERW (Electric Resistance Welded) seam welds as compared to metal base in API 5L steel pipes

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Velasquez, Jorge L.; Godinez Salcedo, Jesus G.; Lopez Fajardo, Pedro [Instituto Politecnico Nacional (IPN), Mexico D.F. (Mexico). Escuela Superior de Ingenieria Quimica e Industrias Extractivas (ESIQIE). Dept. de Ingenieria Metalurgica

    2009-07-01

    The corrosion resistance of ERW seam welds and the base metal in API 5L X70 steel pipes was evaluated by Tafel tests. The procedure was according to ASTM G3 standard. The study was completed with metallographic and chemical characterization of the tested zones, that is, the welded zone and the base metal away of the weld. All tests were made on the internal surface of the pipe in order to assess the internal corrosion of an in-service pipeline made of the API 5L X70 steel. The test solution was acid brine prepared according to NACE Publications 1D182 and 1D196. The results showed that the ERW seam weld corrodes as much as three times faster than the base material. This behavior is attributed to a more heterogeneous microstructure with higher internal energy in the ERW seam weld zone, as compared to the base metal, which is basically a ferrite pearlite microstructure in a normalized condition. This result also indicates that pipeline segments made of ERW steel pipe where the seam weld is located near or at the bottom of the pipe are prone to a highly localized attack that may form channels of metal loss if there is water accumulation at the bottom of the pipeline. (author)

  15. Study of phase transformations In API 5L X80 Steel in order to increase its fracture toughness

    Directory of Open Access Journals (Sweden)

    Igor Rafael Vilarouco Pedrosa

    2013-04-01

    Full Text Available Phase transformations in API 5L X80 steel were studied in different thermomechanical sequences with a view to increasing the fracture toughness of this steel. Dilatometry tests performed on the quenched steel detected a phase transformation occurred, during heating, in the temperature range 593-618 K. This phase transformation was identified as the dissolution of M-A islands. Based on preliminary dilatometric tests, ten thermal and thermomechanical treatments were performed on X80 steel samples. Initially, the material was hot rolled and quenched and only quenched. On the material without deformation, aging was also performed at temperatures of 603, 673, 723, 773, 823 and 873 K. These treatments resulted in the formation of the acicular ferrite constituent, among others. Tensile tests showed that the aging treatments produced reductions in yield strength and increases in the elongation and toughness of X80 steel. All the treatments resulted in an increase in the tensile strength of steel.

  16. Comportamiento de Laminaciones Coplanares y No Coplanares en Acero API5L X52 Simuladas mediante Elementos Finitos Behavior of Coplanar and Non-Coplanar Laminations in API5L X52 Steel Simulated by Finite Elements

    Directory of Open Access Journals (Sweden)

    Alberto Servin

    2009-01-01

    Full Text Available Se determina el comportamiento mecánico de laminaciones simples y escalonadas modeladas por elementos finitos en condiciones no lineales de esfuerzo-deformación, para comprender la secuencia de la interacción de los campos de esfuerzos en los extremos de la grietas. Se estableció una matriz de simulación variando la extensión circunferencial de las laminaciones, con espesor del tubo de 610mm de diámetro, con separación vertical y horizontal para el caso de laminaciones escalonadas. Se determino la función de distribución de esfuerzos en la región de las laminaciones en función de la presión en la grieta y en el tubo. Se estableció la presión que origina alcanzar la cedencia y resistencia ultima del material API5L X52, determinando que las laminaciones simples cuya extensión circunferencial va de 24 a 127 mm, soportan 50% más de presión de cedencia que las laminaciones escalonadas, y el 100% más de presión máxima permisible. Basados en la graficas presión versus radio de las laminaciones se concluye que las laminaciones no coplanares representan mayor riesgo de agrietamiento en una tubería.The mechanical behavior of the coplanar and non coplanar laminations by finite element using non lineal material conditions was determined, with the purpose of knowing the interaction sequence of the stress fields in the crack tips. The analysis includes a matrix simulation considering the circumferential length lamination, wall thickness of the pipe 610mm diameter, with vertical and horizontal distance for non coplanar laminations. The stress distribution in the laminations regions as a function of the internal pressures in the cracks and pipe were determined. The simulations done allowed defining the yield and the strength pressure that reach the mechanical properties of the API 5L X52. It was found that coplanar laminations with 24 at 127mm of circumferential length resist 50% more yield pressure than the non coplanar laminations and

  17. KAYNAKLI API 5L X65 BORU HATTI ÇELİKLERİNİN KlRlLMA TOKLUGU

    Directory of Open Access Journals (Sweden)

    HÜSEYİN UZUN

    2002-06-01

    Full Text Available Petrol ve dogal gaz boru hatla rında ya ygın olarak kulla nıla n ve ta ndem tozaltı ka yna k metodu ile bir leşt irilen API 5L X65 d u al fa zlı çeliğin kırılma to lduğu tespit edilmiştir. Kırılma to lduğu, çentikli üç nokta kırılma tokluğu deneyi kulla nıla ra k belirlenmiştir. Çentik, hem kayna k dikişinin or tası na hem de ısının tesiri altında ki bölgesi (IT AB içerisinin içine gelecek şekilde aç ılarak deney uygula nmıştır. Her bir nurnuneye gerilim giderme ta vlaması uygul anarak, kırılma tokluğu değerler inin nasıl etkilendiği değerlendirilmiştir. Elde edilen sonuçlara göre, gerilim giderme ta vı uygula nmamış ve uygulanmış numunelerde, kaynak dikişin in kırılma to ld u ğ u , IT AB bölgesinin kırılma to lduğundan daha yüksek çıkmıştır. Anahtar Kelimeler - API 5L X65 çeliğinin kırılma tokluğu, spira l dikişli borular, ta ndem tozaltı kaynağı. Abstract -The fra cture toughness of API 5L X65 dual­phase steel welded by ta ndem submerged are welding process, which is used widely petrolenın and na tural gas pipelines, wa s investigated. The fra cture toughness values were obta ined using by three point bend fracture toughness test specimens. The notch was machined either in the center of w el d meta l or the heat affected zone (H AZ. It wa s employed stress relief annealing in order to inves tigate the effect heat treatment on the fra cture toughness va lues. The results show tha t the fracture toughness va lues of weld metal with both heat treatment and non-h eat treatment are higher than that of the heat affected zone. Keywords - Fracture toughness of API 5L X65 steel, sp ira ll y welded pipeline, tandem submerged are welding. ı. GİRİŞ Doğal gaz ve petrol taşıma borularında, sistemin emniyeti için API 5L standardına uygun sertifikalı borular tercih edilmektedir. Bu standarda göre, boyuna veya H. UZUN: Sakarya Üniversitesi, Teknik Eğitim Fak

  18. 对APISPEC5L/ISO3183超声波探伤对比标样的认识%Cognition of Ultrasonic Testing Reference Specimen in API SPEC 5L/ISO 3183

    Institute of Scientific and Technical Information of China (English)

    甘正红; 任文浩

    2011-01-01

    According to the reflection theory to ultrasonic testing reflection signal of several reference specimens specified in API SPEC 5L/ISO3183, this paper pointed out the respective reflection characteristics, and conducted analysis in conjunction with acceptance criteria. It put forward utilizing reference specimen according to different reflection regulation and equivalent weight to ultrasonic of notches and radial drilling hole (column hole), the both parties of contract should clearly stipulate acceptance reference specimen when adopting API SPEC 5L (44 edition) / ISO3183 standard; The level of sensitivity shall be tested and analyzed combining with the specific condition instead of simply determining result based on differences of artificial reflectors.%依据API SPEC 5L/ISO 3183标准规定的几种超声波探伤对比标样对超声波反射信号的反射理论,指出它们的各自反射特性,结合验收标准进行分析.提出了在使用对比标样时应根据刻槽和径向钻孔(柱孔)对超声波的反射规律不同、当量不同,建议在使用API SPEC 5L(第44版)/ISO3183标准时,合同双方应明确规定验收对比标样;灵敏度的高低不能简单地以人工反射体的差异来判定,要结合具体条件进行测试和分析.

  19. Microbial Corrosion of API 5L X-70 Carbon Steel by ATCC 7757 and Consortium of Sulfate-Reducing Bacteria

    Directory of Open Access Journals (Sweden)

    Arman Abdullah

    2014-01-01

    Full Text Available Various cases of accidents involving microbiology influenced corrosion (MIC were reported by the oil and gas industry. Sulfate reducing bacteria (SRB have always been linked to MIC mechanisms as one of the major causes of localized corrosion problems. In this study, SRB colonies were isolated from the soil in suspected areas near the natural gas transmission pipeline in Malaysia. The effects of ATCC 7757 and consortium of isolated SRB upon corrosion on API 5L X-70 carbon steel coupon were investigated using a weight loss method, an open circuit potential method (OCP, and a potentiodynamic polarization curves method in anaerobic conditions. Scanning electron microscopy (SEM and energy dispersive X-ray spectroscopy (EDS were then used to determine the corrosion morphology in verifying the SRB activity and corrosion products formation. Results from the study show that the corrosion rate (CR of weight loss method for the isolated SRB is recorded as 0.2017 mm/yr compared to 0.2530 mm/yr for ATCC 7757. The Tafel plot recorded the corrosion rate of 0.3290 mm/yr for Sg. Ular SRB and 0.2500 mm/yr for Desulfovibrio vulgaris. The results showed that the consortia of isolated SRB were of comparable effects and features with the single ATCC 7757 strain.

  20. Study of texture and microstructure evaluation of steel API 5L X70 under various thermomechanical cycles

    Energy Technology Data Exchange (ETDEWEB)

    Masoumi, Mohammad, E-mail: Mohammad@alu.ufc.br; Herculano, Luis Flavio Gaspar; Ferreira Gomes de Abreu, Hamilton

    2015-07-15

    This work studies the influence of different thermomechanical paths on the microstructure and crystallographic texture across the thickness of API 5L X70 pipeline steel manufactured via hot rolling using X-ray diffraction (XRD), scanning electron microscope (SEM), and electron backscattered diffraction (EBSD). The starting materials were controlled hot-rolled at 1000 °C to 44% and 67% reductions and subsequently heat treated with such processes as annealing, water quenching and quench tempering at three different temperatures to evaluate the microstructure and crystallographic texture changes across the thickness. The banded ferrite-pearlite microstructure of the initial material was changed to acicular ferrite, quasi-polygonal ferrite, granular bainite, martensite and retained austenite via different heat treatments. Moreover, different thermomechanical paths induced crystallographic texture variations across the thickness, e.g., {112}//ND, {111}//ND (γ fibre), and {011}//ND fibres dominated on the surface plane in contact with the rolls, whereas {001}//ND and particularly the (001)[1 1 0] texture component developed in the centre plane on which shear deformation has a zero value in this region. In this study, a simple interpretation of texture evolution was analyzed by comparison with the orientation changes that occurred during different rolling schedules and post-treatment processes.

  1. Influencia del precalentamiento en las propiedades de uniones soldadas de acero API 5L-X80 soldadas con alambre tubular autoprotegido

    Directory of Open Access Journals (Sweden)

    Cooper, R.

    2004-08-01

    Full Text Available The present work refers to the characterization of API 5L-X80 pipeline joints welded with self-shielded flux cored wire. This process was evaluated under preheating conditions, with an uniform and steady heat input. All joints were welded in flat position (IG, with the pipe turning and the torch still. Tube dimensions were 762 mm in external diameter and 16 mm in thickness. Welds were applied on single V-groove, with six weld beads, along with three levels of preheating temperatures (room temperature, 100 °C, 160 °C. These temperatures were maintained as interpass temperature. The filler metal E71T8-K6 with mechanical properties different from parent metal was used in undermatched conditions. The weld characterization is presented according to the mechanical test results of tensile strength, hardness and impact test. The mechanical tests were conducted according to API 1104, AWS and ASTM standards. API 1104 and API 51 were used as screening criteria. According to the results obtained, it was possible to remark that it is appropriate to weld API 5L-X80 steel ducts with Self-shielded Flux Cored wires, in conformance to the API standards and no preheat temperature is necessary.

    Este trabajo presenta un estudio sobre la caracterización de las propiedades mecánicas de uniones soldadas con alambre tubular autoprotegido, de acero API 5L-X80. En este sentido, se evalúa la influencia de la temperatura de precalentamiento, manteniendo el aporte de calor uniforme. Todas las uniones soldadas se realizaron en la posición plana (IG, con la antorcha fíja y la tubería girando. Se utilizó un tubo de 762 mm de diámetro exterior y 16 mm de espesor. Las soldaduras se aplicaron sobre una unión de tope con bisel en V simple, utilizando 6 pasadas, con tres niveles de temperatura de precalentamiento (ambiente, 100 °C y 160 °C. Estas temperaturas se mantuvieron como temperatura entre pasadas. El metal de aporte, del tipo E71T8-K6, se utilizó en la

  2. Influence of preheating on API 5L-X80 pipeline joint welding with self shielded flux-cored wire; Influencia del precalentamiento en las propiedades de uniones soldadas de acero API 5L-X80 soldadas con alambre tubular autoprotegido

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, R.; Silva, J. H. F.; Trevisan, R. E.

    2004-07-01

    The present work refers to the characterization of API 5L-X80 pipeline joints welded with self-shielded flux cored wire. This process was evaluated under preheating conditions, with an uniform and steady heat input. All joints were welded in flat position (1G), with the pipe turning and the torch still. Tube dimensions were 762 mm in external diameter and 16 mm in thickness. Welds were applied on single V-groove, with six weld beads, along with three levels of preheating temperatures (room temperature, 100 degree centigree, 160 degree centigree). These temperatures were maintained as inter pass temperature. The filler metal E71T8-K6 with mechanical properties different from parent metal was used in under matched conditions. The weld characterization is presented according to the mechanical test results of tensile strength, hardness and impact test. The mechanical tests were conducted according to API 1104, AWS and ASTM standards. API 1104 and API 51 were used as screening criteria. According to the results obtained, it was possible to remark that it is appropriate to weld API 5L-X80 steel ducts with Self-shielded Flux Cored wires, in conformance to the API standards and no preheat temperature is necessary. (Author) 22 refs.

  3. The Effect of Temperature and Acid Gas Loading on Corrosion Behavior of API 5L X52 Carbon Steel in Amine Unit

    Science.gov (United States)

    Javidi, M.; Lalehparvar, M. M.; Ghassemi, A.

    2016-05-01

    The effect of temperature and H2S concentration on amine corrosion of API 5L X52 carbon steel in a CO2-saturated 25 wt.% diethanolamine solution was investigated via electrochemical techniques. It was found that increase in temperature from 25 to 80 °C resulted in severe increase in corrosion rate from 0.88 to 16.24 mpy due to increase in degradation rate of amine. Also, it was concluded that increase in H2S concentration led to increase in corrosion rate because of formation of more heat stable amine salts. The effect of temperature on corrosion rate was more significant than acid gas loading.

  4. Influencia del precalentamiento en las propiedades de uniones soldadas de acero API 5L-X80 soldadas con alambre tubular autoprotegido

    OpenAIRE

    Cooper, R.; Silva, J. H.F.; Trevisan, R. E.

    2004-01-01

    The present work refers to the characterization of API 5L-X80 pipeline joints welded with self-shielded flux cored wire. This process was evaluated under preheating conditions, with an uniform and steady heat input. All joints were welded in flat position (IG), with the pipe turning and the torch still. Tube dimensions were 762 mm in external diameter and 16 mm in thickness. Welds were applied on single V-groove, with six weld beads, along with three levels of preheating temperatures (room te...

  5. APIs

    CERN Document Server

    Jacobson, Daniel; Woods, Dan

    2011-01-01

    Programmers used to be the only people excited about APIs, but now a growing number of companies see them as a hot new product channel. This concise guide describes the tremendous business potential of APIs, and demonstrates how you can use them to provide valuable services to clients, partners, or the public via the Internet. You'll learn all the steps necessary for building a cohesive API business strategy from experts in the trenches. Facebook and Twitter APIs continue to be extremely successful, and many other companies find that API demand greatly exceeds website traffic. This book offe

  6. Discussion about Several Problems on Evaluating X-ray Image According to API SPEC 5L%API SPEC 5L标准射线底片评定过程中的几个问题的探讨

    Institute of Scientific and Technical Information of China (English)

    王晨; 侯永高; 张道峰; 闻康

    2007-01-01

    @@ 随着西气东输等长输管线的建立,我国又迎来了一个管线建设的新的高峰.钢管生产检测在国内无损检测所占比例逐渐加大.钢管厂常年使用的标准主要是GB 9711.1-1997、GB 9711.2-1999和API SPEC 5L.在API SPEC 5L标准的具体使用过程中,由于美国标准体系和工作惯例与我国在其它领域采用的射线检测存在一些不同,造成对标准底片评定的理解存在一定的模糊,下面将在常年使用API SPEC 5L标准的经验中发现的一些问题提出来,供同行参考和斧正.

  7. Discussion on Tensile Test Elongation in API SPEC 5L(45th Version)%对API SPEC 5L(45版)中有关拉伸试验伸长率的讨论

    Institute of Scientific and Technical Information of China (English)

    李记科; 杨红兵

    2015-01-01

    In this article, after discussion on tensile test elongation in API SPEC 5L (45th version) 10.2.4 clause, it considered its standard requirements are unreasonable. It suggests to adopt the requirements in the 6.2.1 clause of API SPEC 5L (43rd version):when elongation is recorded or reported, the record or report shall show the nominal width of the test specimen when strip specimens are used and the diameter and gauge length when round bar specimens are used, or shall state when full section specimens are used. Or the standard requirements are modified to:The percentage elongation of 4 times proportion test pieces (gauge length is 4 times the diameter of the round test pieces, L0=4D0, k= L0≈4.5 ) after fracture shall be reported.√S0 For test pieces with reference to a gauge length of 50 mm(2 in), the measured elongation after fracture shall be converted to a percentage elongation of 4 times proportion test pieces in accordance with ISO 2566-1 or ASTM A370.%对API SPEC 5L (45版)10.2.4试验方法中有关拉伸试验伸长率的内容进行了讨论,认为其标准要求不合理。建议采用API SPEC 5L (43版)6.2.1拉伸性能条款中的要求:“当需记录或报告伸长率时,如采用板状试样,记录或报告中应注明试样的公称宽度;如采用圆棒试样,应注明直径和标距长度;如采用全断面试样亦应予以注明”。或者修改为:“应报告4倍比例试样(标距长度为4倍直径的棒状试样, L0=4D0, k= L0√S0≈4.5)的断后伸长率。对于采用50 mm(2 in)定标距试样,应按照ISO 2566-1或ASTM A370,将断裂后测得的伸长率转换为4倍比例试样的断后伸长率。”

  8. Estudio del daño por hidrógeno en uniones soldadas de un acero API 5L X52

    Directory of Open Access Journals (Sweden)

    Réquiz, R.

    2008-04-01

    Full Text Available The main objective of the present investigation was to study the susceptibility to hydrogen damage on a type API 5L X52 steel welded by electrical resistance. Several techniques, such as hydrogen permeation and cathodic charging were used. The metallic material was characterized using SEM and TEM. The base metal microstructure was very similar to that one corresponding to the welded area. This microstructure was mainly comprised by ferrite and perlite, differing only in the grain size. Therefore, the susceptibility to hydrogen damage was similar in both cases. It is worth mentioning that the welded area has very small dimensions. Indeed, the fusion zone is only 5 mm wide while the heat affected zone is 1 mm wide. The hydrogen damage observed was mainly in the form of blisters, which were associated to the presence of aluminum rich inclusions. Also, it was noticed partial inclusion dissolution and some matrix attack adjacent to the inclusions.

    En la presente investigación se estudió la susceptibilidad al daño por hidrógeno en un acero API 5L X52 soldado por resistencia eléctrica. Para ello, se emplearon técnicas de permeación y de carga catódica de hidrógeno. El material fue caracterizado mediante microscopía electrónica de barrido y de transmisión. La susceptibilidad al daño por hidrógeno fue similar tanto en el metal base como en el cordón de soldadura. Este comportamiento se vincula a la microestructura homogénea constituida por perlita y ferrita, que presentan ambos, aun cuando existen diferencias en el tamaño de grano. El cordón de soldadura tenía dimensiones muy pequeñas, donde la zona de fusión y la afectada por el calor poseen espesores de 5 mm y 1 mm, respectivamente. El daño inducido por hidrógeno se presentó en forma de ampollas en la superficie del material, asociado, principalmente, a la presencia de inclusiones globulares y semiglobulares ricas en aluminio. Además, se manifestó una disoluci

  9. Numerical Evaluation of Temperature Field and Residual Stresses in an API 5L X80 Steel Welded Joint Using the Finite Element Method

    Directory of Open Access Journals (Sweden)

    Jailson A. Da Nóbrega

    2016-01-01

    Full Text Available Metallic materials undergo many metallurgical changes when subjected to welding thermal cycles, and these changes have a considerable influence on the thermo-mechanical properties of welded structures. One method for evaluating the welding thermal cycle variables, while still in the project phase, would be simulation using computational methods. This paper presents an evaluation of the temperature field and residual stresses in a multipass weld of API 5L X80 steel, which is extensively used in oil and gas industry, using the Finite Element Method (FEM. In the simulation, the following complex phenomena were considered: the variation in physical and mechanical properties of the material as a function of the temperature, welding speed and convection and radiation mechanisms. Additionally, in order to characterize a multipass weld using the Gas Tungsten Arc Welding process for the root pass and the Shielded Metal Arc Welding process for the filling passes, the analytical heat source proposed by Goldak and Chakravarti was used. In addition, we were able to analyze the influence of the mesh refinement in the simulation results. The findings indicated a significant variation of about 50% in the peak temperature values. Furthermore, changes were observed in terms of the level and profile of the welded joint residual stresses when more than one welding pass was considered.

  10. Caracterización de Revestimientos de Niobio formados por Aspersión Térmica a Plasma sobre Acero API 5l X65 Characterization of Niobium Coatings obtained by Plasma Spray Thermal Substrate on Steel API 5l X651

    OpenAIRE

    José F Matos; Felipe P Motta; Ester S Rieder; Célia F. Malfatti

    2012-01-01

    Se evaluó la morfología y el comportamiento electroquímico del revestimiento de niobio obtenido por el proceso de aspersión térmica a plasma en substrato de acero API 5L X65. El revestimiento con niobio se realizó con una corriente eléctrica de 500 A, flujo de polvo metálico de niobio de 15 g/min y gas de argón de 2.0 L/min. La preparación superficial del substrato se realiza con pre-calentamiento y limpieza a presión con abrasivo de alúmina. La morfología del revestimiento fue analizada por ...

  11. Caracterización de Revestimientos de Niobio formados por Aspersión Térmica a Plasma sobre Acero API 5l X65 Characterization of Niobium Coatings obtained by Plasma Spray Thermal Substrate on Steel API 5l X651

    Directory of Open Access Journals (Sweden)

    José F Matos

    2012-01-01

    Full Text Available Se evaluó la morfología y el comportamiento electroquímico del revestimiento de niobio obtenido por el proceso de aspersión térmica a plasma en substrato de acero API 5L X65. El revestimiento con niobio se realizó con una corriente eléctrica de 500 A, flujo de polvo metálico de niobio de 15 g/min y gas de argón de 2.0 L/min. La preparación superficial del substrato se realiza con pre-calentamiento y limpieza a presión con abrasivo de alúmina. La morfología del revestimiento fue analizada por microscopía electrónica de barrido (MEB, la rugosidad de la superficie se evaluó por perfilometría, la dureza por micro-dureza Vickers y la adherencia por ensayado de doblado a 180°. La resistencia a la corrosión del revestimiento se determinó mediante el ensayo de polarización en una solución de NaVl 3,5%. A partir de los resultados obtenidos fue posible verificar que el revestimiento presentó fisuras y poros entre las placas rociadas además de una dureza elevada en relación al substrato y adherencia no adecuada. Aún así los valores de densidad de corriente desarrollados por el sistema en comparación al acero revestido se redujeron.The morphology and electrochemical behavior of niobium coating obtained by thermal plasma spray process on a substrate of steel API 5L X65 was evaluated. The coating was obtained, using electrical current of 500 A, 15 g/min of powder and 2.0 L/min of argon gas. The preparation of the substrate surface was performed with preheating and abrasive blasting with alumina. After thermal spraying, the morphology of the coating was analyzed by scanning electron microscopy (SEM, while the surface roughness was evaluated by profilometry, hardness by Vickers microhardness test and adhesion by bending at 180 °. The corrosion resistance of the coating was evaluated from the polarization test in 3.5% NaVl solution. The results show that the coating presented cracking and lack of padding between the plates sprayed

  12. Avaliação da microestrutura e propriedades mecânicas de metais de solda obtidos por processos de soldagem manual e automatizado utilizado na soldagem de aço API 5L X80 Evaluation of microstructure and mechanical properties of weld metals obtained by manual and automated welding process used in the welding of API 5L X80 steel

    Directory of Open Access Journals (Sweden)

    Siderley Fernandes Albuquerque

    2011-12-01

    Full Text Available O objetivo do trabalho foi avaliar as características da zona termicamente afetada (ZTA e a microestrutura e propriedades mecânicas de metais de solda de juntas soldadas do aço API 5L X80, obtidos para quatro diferentes procedimentos de soldagem utilizando processos manuais e automatizados. Para isto, chapas do referido aço foram soldadas por processo manual ao Arco Elétrico com Eletrodo Revestido (SMAW, utilizando 473 e 673 K como temperaturas de interpasses e o eletrodo celulósico AWS E8010-G como consumível; por processo ao Arco Elétrico com Arame Tubular (FCAW robotizado, utilizando o arame AWS E71T- 1C como metal de adição e argônio com 25%CO2 como gás de proteção; por processo a Arco Elétrico com Eletrodo de Tungstênio (GTAW mecanizado na raiz da solda, usando o arame ER70S-3 e argônio como gás de proteção. As análises microestruturais foram relacionadas com os resultados de ensaios de impacto Charpy nos metais de solda e com os perfis de microdureza Vickers ao longo da junta soldada. Os resultados indicaram maiores percentuais de Ferrita Acicular e maiores valores de resistência ao impacto nos metais de solda e uma menor extensão e granulometria da ZTA, associado ao procedimento de soldagem utilizando processo automatizado com maior velocidade de soldagem.The objective of this work was to evaluate the heat affected zone characteristics and weld metals microstructure and mechanical properties of API 5L X80 steel welded joints, obtained for four different welding procedures using manual and automated processes. For this, plates of this steel were welded by manual Shielded Metal Arc Welding (SMAW process with interpasses temperatures of 473 e 673 K, and using AWS E8010-G electrode as filler metals; robotized Flux Cored Arc Welding (FCAW process, using AWS E71T-1C wire and Ar25%CO2 as consumable and mechanized Gas Tungsten Arc Welding (GTAW process, for the root pass using AWS ER70S-3 and Ar as consumable .The

  13. Pioneer ACO PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — Pioneer ACO PUF - To address the increasing number of requests for Pioneer ACO data, the Centers for Medicare and Medicaid Services (CMS) has created a standard...

  14. Pioneer ACO Model

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Pioneer ACO Model is designed for health care organizations and providers that are already experienced in coordinating care for patients across care settings....

  15. Evaluación de la susceptibilidad a la corrosión por picado del acero API 5L x42 expuesto a un ambiente con cloruros y CO2 mediante la técnica de ruido electroquímico

    Directory of Open Access Journals (Sweden)

    Rodríguez-Vanegas, N.

    2011-10-01

    Full Text Available The concentration of chloride ions and the partial pressure of CO2 play an important role in the degradation of low-carbon steels used for the construction of pipelines in oil and gas industry. In order to evaluate the susceptibility of carbon steel API 5L X42 to pitting corrosion electrochemical noise and linear polarization resistance measurements were carried out in aqueous solutions containing chloride ions and CO2. The concentration of chloride ions was varied between, 10000 and 18000 ppm, and the CO2 partial pressure between 10 psi and 18 psi. Experimental results pointed out that the formation of protective layer, consisting mainly of FeCO 3, depends on the partial pressure of CO2 in the system. Nevertheless, the stability of this layer was considerably affected by increasing the concentration of chloride ions causing that localized corrosion has taken place in some areas of the surface of API 5L X42, which were detected by electrochemical noise echnique.La concentración de iones cloruro y la presión parcial de CO2, tienen un papel importante en el proceso de degradación de los aceros de bajo carbono empleados en la construcción de líneas de transporte en industrias petroleras. Con el fin de evaluar la susceptibilidad del acero al carbono API 5L X42 a la corrosión por picado, se realizaron medidas de ruido electroquímico y resistencia a la polarización lineal en soluciones acuosas de iones cloruro con concentraciones entre 10.000 y 18.000 ppm, variando la presión parcial de CO2 entre 10 psi y 18 psi. Los resultados indican que la formación de una capa protectora, constituida principalmente por FeCO3, depende de la presión parcial de CO2 del sistema. No obstante, la estabilidad de dicha capa es afectada significativamente por el aumento de la concentración de iones cloruro, que producen fenómenos de corrosión localizada en algunas áreas de la superficie del acero API 5L X42, los cuales fueron detectados por la técnica de

  16. Susceptibilidad a grietas inducidas por hidrógeno en ambiente corrosivo de H2S de juntas soldadas de acero API 5L-X80

    Directory of Open Access Journals (Sweden)

    Hilton, J.

    2009-08-01

    Full Text Available The susceptibility to hydrogen-induced cracking in H2S environment of welded API X80 steel was studied. The flux cored arc welding (FCAW process was employed with E71-T1 and E71-T8K6 wires. The welding parameters were kept constant, but the samples were welded using different preheat temperatures (room temperature and 100ºC. The gapped bead-on-plate (G-BOP test was used. The specimens of modified G-BOP tests were exposed to an environment saturated in H2S, as recommended by the NACE TM0284 standard. The weld beads were characterized by optical microscopy and the level of residual hydrogen in the samples was measured. The fracture surface areas of hydrogen-induced cracking were calculated and the fracture mode was discussed. It was found that the preheating temperature of 100ºC was enough to avoid cracking, even in the presence of H2S. It was also found that the E71- T8K6 wire was more susceptible to cracking, and the typical mixed-mode fracture was predominant in all samples.

    En este trabajo fue realizado un estudio sobre la susceptibilidad al agrietamiento inducido por el hidrógeno de uniones soldadas de aceros API –X80, expuestas a un ambiente saturado en ácido sulfhídrico (H2S. Fue empleado el ensayo G-BOP modificado. El proceso de alambre tubular, con dos metales de aporte, E71-T1 y E71-T8K6, fue usado, manteniendo constante los parámetros del proceso de soldadura. Las probetas fueron soldadas a temperatura ambiente y también tras precalentamiento a 100ºC. Los bloques soldados del ensayo G-BOP modificado fueron expuestos a un ambiente saturado en H2S, según recomienda la norma NACE TM0284. Los cordones de soldadura fueron caracterizados microestructuralmente y realizados análisis de hidrógeno residual en las probetas. Se observaron y calcularon las áreas de las superficies de fractura de las grietas inducidas por el hidrógeno y se analizaron

  17. The Revision on the 44th Version of API SPEC 5L "Standards of Pipeline Tube" from American Petroleum Institute%美国石油学会对API SPEC 5L《管线管规范》第44版的修改

    Institute of Scientific and Technical Information of China (English)

    许晓锋; 方伟

    2009-01-01

    针对API SPEC 5L《管线管规范》第44版,美国石油学会于2009年1月发布了勘误,并于2月又发布了补充件,对附录N(规范性附录)及附录O(资料性附录)进行了修改。为使API油套管相关生产厂、油田用户、监督检验人员等尽快了解、掌握该标准的这些变化,在生产实践中更准确地使用该标准,现将其最新修改内容简介如下。

  18. Recalls API

    Data.gov (United States)

    General Services Administration — This Recalls API allows you to tap into a list of (1) drug and food safety recalls from the Food and Drug Administration, Food Safety and Inspection Service, and...

  19. Helioviewer API

    Data.gov (United States)

    National Aeronautics and Space Administration — The Helioviewer Project maintains a set of Public APIs with the goal of improving access to solar and heliospheric datasets to scientists, educators, developers,...

  20. Jobs API

    Data.gov (United States)

    General Services Administration — This Jobs API returns job openings across the federal government and includes all current openings posted on USAJobs.gov that are open to the public and located in...

  1. Facebook API

    OpenAIRE

    Hlaváček, Josef

    2011-01-01

    Bachelor Thesis deals with Facebook Platform utilization in web application development. Thesis is devided into five chapters, three of them are theoretical and two are pracical. First chapter deals with web APIs in general view and provides information about the basic comunication methods. The second chapter focuses on Facebook architecture, specific Facebook APIs, FQL and the Facebook Platform. The third chapter introduces Facebook Developer tools, CakePHP framework and describes setting up...

  2. Feocromocitoma cardíaco

    Directory of Open Access Journals (Sweden)

    Gustavo L. Knop

    2006-01-01

    Full Text Available Los feocromocitomas cardíacos primarios (FCP son sumamente infrecuentes. Hasta el presente son menos de 50 los casos comunicados en el mundo. Presentamos el caso de un tumor intrapericárdico, que resultó ser un feocromocitoma primario, en una mujer de mediana edad, cuyo signo principal fue hipertensión arterial severa (HTAs. Los estudios diagnósticos por imágenes corroboraron la presencia de un tumor intrapericárdico como único hallazgo y los estudios bioquímicos de catecolaminas y sus metabolitos excretados por orina reafirmaron el diagnóstico etiológico. El tumor fue resecado quirúrgicamente sin complicaciones mediante cirugía cardíaca convencional con circulación extracorpórea (CEC y paro cardíaco con cardioplejía. Siete meses después de la operación, la paciente se encuentra asintomática y normotensa.

  3. Including Language Access into Medicaid ACO Design.

    Science.gov (United States)

    Gershon, Rachel; Morris, Lisa; Ferguson, Warren

    2016-09-01

    Quality health care relies upon communication in a patient's preferred language. Language access in health care occurs when individuals are: (1) Welcomed by providers regardless of language ability; and (2) Offered quality language services as part of their care. Federal law generally requires access to health care and quality language services for deaf and Limited English Proficient (LEP) patients in health care settings, but these patients still find it hard to access health care and quality language services.Meanwhile, several states are implementing Medicaid Accountable Care Organization (ACO) initiatives to reduce health care costs and improve health care quality. Alternative payment methods used in these initiatives can give Accountable Care Organizations more flexibility to design linguistically accessible care, but they can also put ACOs at increased financial risk for the cost of care. If these new payment methods do not account for differences in patient language needs, ACO initiatives could have the unintended consequence of rewarding ACOs who do not reach out to deaf and LEP communities or offer quality language services.We reviewed public documents related to Medicaid ACO initiatives in six states. Some of these documents address language access. More could be done, however, to pay for language access efforts. This article describes Medicaid ACO initiatives and explores how different payment tools could be leveraged to reward ACOs for increased access to care and quality language services. We find that a combination of payment tools might be helpful to encourage both access and quality. PMID:27587453

  4. Drug Interaction API

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Interaction API is a web service for accessing drug-drug interactions. No license is needed to use the Interaction API. Currently, the API uses DrugBank for its...

  5. Study of an API migration for two XML APIs

    NARCIS (Netherlands)

    Bartholomei, T.T.; Czarnecki, K.; Lämmel, R.; Storm, T. van der; Brand, M.G.J. van den; Gasevic, D.; Gray, J.

    2010-01-01

    API migration refers to adapting an application such that its dependence on a given API (the source API) is eliminated in favor of depending on an alternative API (the target API) with the source and target APIs serving the same domain. One may attempt to automate API migration by code transformatio

  6. Analyzing the Change-Proneness of APIs and web APIs

    OpenAIRE

    Romano, D.

    2015-01-01

    Analyzing the Change-Proneness of APIs and web APIs APIs and web APIs are used to expose existing business logic and, hence, to ease the reuse of functionalities across multiple software systems. Software systems can use the business logic of legacy systems by binding their APIs and web APIs. With the emergence of a new programming paradigm called service-oriented, APIs are exposed as web APIs hiding the technologies used to implement legacy systems. As a consequence, web APIs establish contr...

  7. Analyzing the Change-Proneness of APIs and web APIs

    NARCIS (Netherlands)

    Romano, D.

    2015-01-01

    Analyzing the Change-Proneness of APIs and web APIs APIs and web APIs are used to expose existing business logic and, hence, to ease the reuse of functionalities across multiple software systems. Software systems can use the business logic of legacy systems by binding their APIs and web APIs. With t

  8. NASA Techport API

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA TechPort system provides a RESTful web services API to make technology project data available in a machine-readable format. This API can be used to export...

  9. Healthcare Finder API

    Data.gov (United States)

    U.S. Department of Health & Human Services — All of the data used on the Finder.HealthCare.gov web application is available through this API. There are multiple collections of data available through the API....

  10. Android quick APIs reference

    CERN Document Server

    Cinar, Onur

    2015-01-01

    The Android Quick APIs Reference is a condensed code and APIs reference for the new Google Android 5.0 SDK. It presents the essential Android APIs in a well-organized format that can be used as a handy reference. You won't find any technical jargon, bloated samples, drawn out history lessons, or witty stories in this book. What you will find is a software development kit and APIs reference that is concise, to the point and highly accessible. The book is packed with useful information and is a must-have for any mobile or Android app developer or programmer. In the Android Quick APIs Refe

  11. API Global Sourcing Strategies 2010.

    Science.gov (United States)

    Bennett, Shannon

    2010-09-01

    The API Global Sourcing Strategies 2010 Conference, held in Berlin, included topics covering new developments in the field of global sourcing of active pharmaceutical ingredients (APIs). This conference report highlights selected presentations on development in Eastern API markets, specifically India and China, factors influencing changes in global API sourcing, and risk mitigation in API sourcing. PMID:20799139

  12. Recent results of the ACO storage ring

    International Nuclear Information System (INIS)

    A permanent magnet undulator has been built and installed on the ACO Storage Ring. The undulator design, the spontaneous emission and gain of the system, as well as the laser induced bunch lengthening of the electron bunch, are presented. A low-loss optical cavity has been also recently built and operated on the ring. Its performance and the degradation problems of the mirrors are discussed. Amplification of the spontaneous emission stored in the optical cavity has been observed. Also, preliminary results on the operation of an optical klystron are reported and interpreted

  13. DIRAC RESTful API

    International Nuclear Information System (INIS)

    The DIRAC framework for distributed computing has been designed as a flexible and modular solution that can be adapted to the requirements of any community. Users interact with DIRAC via command line, using the web portal or accessing resources via the DIRAC python API. The current DIRAC API requires users to use a python version valid for DIRAC. Some communities have developed their own software solutions for handling their specific workload, and would like to use DIRAC as their back-end to access distributed computing resources easily. Many of these solutions are not coded in python or depend on a specific python version. To solve this gap DIRAC provides a new language agnostic API that any software solution can use. This new API has been designed following the RESTful principles. Any language with libraries to issue standard HTTP queries may use it. GSI proxies can still be used to authenticate against the API services. However GSI proxies are not a widely adopted standard. The new DIRAC API also allows clients to use OAuth for delegating the user credentials to a third party solution. These delegated credentials allow the third party software to query to DIRAC on behalf of the users. This new API will further expand the possibilities communities have to integrate DIRAC into their distributed computing models.

  14. Google Ajax Search API

    CERN Document Server

    Fitzgerald, Michael

    2007-01-01

    Use the Google Ajax Search API to integrateweb search, image search, localsearch, and other types of search intoyour web site by embedding a simple, dynamicsearch box to display search resultsin your own web pages using a fewlines of JavaScript. For those who do not want to write code,the search wizards and solutions builtwith the Google Ajax Search API generatecode to accomplish common taskslike adding local search results to a GoogleMaps API mashup, adding videosearch thumbnails to your web site, oradding a news reel with the latest up todate stories to your blog. More advanced users can

  15. Corporate Consumer Contact API

    Data.gov (United States)

    General Services Administration — The data in the Corporate Consumer Contact API is based on the content you can find in the Corporate Consumer Contact listing in the Consumer Action Handbook (PDF)....

  16. GIBS API for Developers

    Data.gov (United States)

    National Aeronautics and Space Administration — API using Global Imagery Browse Services (GIBS) designed to deliver global, full-resolution satellite imagery to users in a highly responsive manner, enabling...

  17. Mars Rover Photos API

    Data.gov (United States)

    National Aeronautics and Space Administration — This API is designed to collect image data gathered by NASA's Curiosity, Opportunity, and Spirit rovers on Mars and make it more easily available to other...

  18. ALOHA Cabled Observatory (ACO): Acoustic Doppler Current Profiler (ADCP): Velocity

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The University of Hawaii's ALOHA ("A Long-term Oligotrophic Habitat Assessment") Cabled Observatory (ACO) is located 100 km north of the island of Oahu, Hawaii (22...

  19. ALOHA Cabled Observatory (ACO): Acoustic Doppler Current Profiler (ADCP): Temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The University of Hawaii's ALOHA ("A Long-term Oligotrophic Habitat Assessment") Cabled Observatory (ACO) is located 100 km north of the island of Oahu, Hawaii (22...

  20. IBM System i APIs at Work

    CERN Document Server

    Vining, Bruce; Hawkins, Ron

    2007-01-01

    This new edition of the bestselling i5 application programming interface (API) book includes powerful new APIs and updated code to give programmers a working knowledge of the APIs available under i5/OS. Using real business-world examples, this book explains APIs that serve webpages, list APIs, APIs that work with user spaces, dynamic index APIs, APIs that retrieve system values, job information and job queue information APIs, APIs that work with data queues, APIs for error handling and message handling, and spool file APIs, among many others. Completely revised and including eight new chapters

  1. Contracting the Facebook API

    Directory of Open Access Journals (Sweden)

    Ben Rubinger

    2010-09-01

    Full Text Available In recent years, there has been an explosive growth in the popularity of online social networks such as Facebook. In a new twist, third party developers are now able to create their own web applications which plug into Facebook and work with Facebook's "social" data, enabling the entire Facebook user base of more than 400 million active users to use such applications. These client applications can contain subtle errors that can be hard to debug if they misuse the Facebook API. In this paper we present an experience report on applying Microsoft's new code contract system for the .NET framework to the Facebook API.We wrote contracts for several classes in the Facebook API wrapper which allows Microsoft .NET developers to implement Facebook applications. We evaluated the usefulness of these contracts during implementation of a new Facebook application. Our experience indicates that having code contracts provides a better and quicker software development experience.

  2. Data.gov CKAN API

    Data.gov (United States)

    General Services Administration — The data.gov catalog is powered by CKAN, a powerful open source data platform that includes a robust API. Please be aware that data.gov and the data.gov CKAN API...

  3. Mars Atmospheric Aggregation System API

    Data.gov (United States)

    National Aeronautics and Space Administration — The {MAAS} API is an open source REST API built to help make it easier and more efficient to build interactive applications that want to utilize the wealth of...

  4. ACO-AFSA Algorithm in Function Optimization and Its Application

    Directory of Open Access Journals (Sweden)

    Wang Shi Gang

    2016-01-01

    Full Text Available ACO and AFSA as two kinds of new intelligent bionic algorithm, has better robustness, and the design method is simple and easy to understand. At present, in many engineering fields, they have been a pivotal position, but there are some defects in solving function optimization problems. Because of the lack of pheromone in the initial stage of ACO, the speed of the solution is relatively slow, and AFSA has the advantages of strong global convergence ability and fast speed. In this paper, based on the advantages and disadvantages of ACO and AFSA, two kinds of algorithms are integrated, and the advantage is enhanced, a better optimization algorithm is put forward: ACO-AFSA. The initial solution and improved state transition probabilities are obtained by AFSA, and the basic ACO is improved, the congestion degree of AFSA is introduced in the algorithm, makes most of ants’ initial optimization will not be randomly selected at a strong crowding restrictions. Experimental results show that the new algorithm can get the optimal solution with less number of iterations, which greatly saves computation time, and has higher accuracy and better convergence performance. Engineering, computing the shortest distance between the surface and plane of the problem has also been good results, the experimental results are satisfactory.

  5. Current Status of the ACO Cluster Redshift Compilation

    CERN Document Server

    Andernach, H; Tago, Erik

    1997-01-01

    We present an update of our compilation of measured redshifts of galaxy clusters in the all-sky Abell catalog. In the last 7 years the number of ACO clusters with measured z has doubled to now ~2100, but still ~56% of these are based on only 1 or 2 measured member galaxies. Our October 1997 version gives 2247 redshifts (including components or line-of-sight superpositions) for 2114 distinct A- and S-clusters. Velocity dispersions are listed for 536 different ACO clusters (613 subclusters) and the median is 695 km/s. We mention some applications of our compilation for determining the large-scale structure of the nearby Universe.

  6. The API petroassist network

    International Nuclear Information System (INIS)

    Past spill responses, such as those in the Exxon Valdez and American Trader incidents, demonstrated the value of companies volunteering their in-house experts and local knowledge to help other companies in spill response. The American Petroleum Institute (API) formed the PetroAssist Network to provide a means for oil companies to readily gain access to the expertise and communications equipment of other oil companies when needed for spill responses. An API work group developed the PetroAssist Network legal agreement and management and activation procedures. To minimize red tape and reduce the burden on members, existing systems were used whenever possible. The network became operational on January 1, 1992, with more than 40 members

  7. Improving Network Performance using ACO Based Redundant Link Avoidance Algorithm

    Directory of Open Access Journals (Sweden)

    B. Chandra Mohan

    2010-05-01

    Full Text Available In the wide spread internet, response time and pocket loss are inappropriate due to network traffic, as a result the network efficiency becomes worst and the system provides poor Quality of Service (QoS. An optimal routing protocol, especially multipath may avoid such traffic in the network. But existing routing protocols, both single path and multi path, concentrates only on finding the routes based on any one or some set of metrics, that not always suitable for dynamic, cloud natured network environment. Ant Colony Optimization (ACO based multipath routing protocol was suggested as an alternate to this problem by many researchers. The multipath ACO also provides same set of link(s for the source to destination, so that traffic merging again becomes a critical problem. This paper proposes an optimal solution to avoid the problem of traffic merging in the network by removing redundant link in the route. The Proposed algorithm, called 'Redundant Link Avoidance (RLA algorithm', is an ACO based multi path routing methodology, avoiding copious link in the suggested routes of ACO multipath protocol.

  8. Evidence of Apis cerana sacbrood virus infection in Apis mellifera

    Science.gov (United States)

    Sacbrood virus (SBV) is one of the most serious threats to Apis cerana but is much less destructive to Apis mellifera. In previous studies, SBV isolates infecting A. cerana and A. mellifera were identified as different serotypes, suggesting a species-barrier of SBV infection. In order to clarify whe...

  9. Web API Fragility: How Robust is Your Web API Client

    NARCIS (Netherlands)

    Espinha, T.; Zaidman, A.; Gross, H.G.

    2014-01-01

    Web APIs provide a systematic and extensible approach for application-to-application interaction. A large number of mobile applications makes use of web APIs to integrate services into apps. Each Web API’s evolution pace is determined by their respective developer and mobile application developers a

  10. AUTOMATED API TESTING APPROACH

    Directory of Open Access Journals (Sweden)

    SUNIL L. BANGARE

    2012-02-01

    Full Text Available Software testing is an investigation conducted to provide stakeholders with information about the quality of the product or service under test. With the help of software testing we can verify or validate the software product. Normally testing will be done after development of software but we can perform the software testing at the time of development process also. This paper will give you a brief introduction about Automated API Testing Tool. This tool of testing will reduce lots of headache after the whole development of software. It saves time as well as money. Such type of testing is helpful in the Industries & Colleges also.

  11. Learning Bing maps API

    CERN Document Server

    Sinani, Artan

    2013-01-01

    This is a practical, hands-on guide with illustrative examples, which will help you explore the vast universe of Bing maps.If you are a developer who wants to learn how to exploit the numerous features of Bing Maps then this book is ideal for you. It can also be useful for more experienced developers who wish to explore other areas of the APIs. It is assumed that you have some knowledge of JavaScript, HTML, and CSS. For some chapters a working knowledge of .Net and Visual Studio is also needed.

  12. Redshifts and Distribution of ACO Clusters of Galaxies

    CERN Document Server

    Andernach, H; Einasto, M; Einasto, J; Jaaniste, J

    2004-01-01

    The June 2004 version of our compilation of measured redshifts for clusters in the Abell-ACO catalogue lists redshifts for 3715 clusters/subclusters in 3033 distinct (2396 A- and 637 S-) clusters, 67% of these with N_z>=3 galaxies measured. We provide velocity dispersions (sigma_V) for 1875 (sub)clusters towards 1353 unique ACO clusters. The median sigma_V is 650 km/s for A-(sub)clusters and 575 km/s for S-(sub)clusters, and sigma_V clearly increases with both, N_z and richness, and also, somewhat surprising, with later Bautz-Morgan type of the clusters. We show examples of supercluster properties based on these data.

  13. An ACO approach for the Parallel Machines Scheduling Problem

    OpenAIRE

    Gatica, Claudia R.; Esquivel, Susana Cecilia; Leguizamón, Guillermo

    2008-01-01

    The parallel machines scheduling problem (Pm) comprises the allocation of jobs on the system’s resources, i.e., a group of machines in parallel. The basic model consists of m identical machines and n jobs. The jobs are assigned according to resource availability following some allocation rule. In this work, we apply the Ant Colony Optimization (ACO) metaheuristic which includes in the construction solution process different specific heuristic to solve Pm for the minimization Maximum Tardiness...

  14. ACO in e-Learning: Towards an adaptive learning path

    Directory of Open Access Journals (Sweden)

    Pushpa. M

    2012-03-01

    Full Text Available Today we are in an era where drastic advancements in networking and information technology are in action. The learning process has also taken these advancements, as a result of which e-learning came to thescene. Personalization in e-learning will improve the performance of the system. Recent researches are concentrating on providing adaptability to the learning management systems, depending upon the varying user needs and contexts. Adaptability can be provided at different levels .Providing an adaptive learning path according to the context of the learners’ is an important issue. An optimal adaptive learning path will help the learners in reducing the cognitive overload and disorientation, and thereby improving the efficiency of the Learning Management System (LMS. Ant Colony Optimization (ACO is a widely accepted technique since it provides an adaptive learning path to the learners. Meta-heuristic which is used in intelligent tutoring systems provides the learning path in an adaptive way. The most interesting feature of ACO is its adaptation and robustness in an environment where the learning materials and learners are changing frequently. In this paper we can have a look through the existing ACO approaches towards providing an adaptive learning path and an introduction towards an enhanced attribute ant for making the e-learning system more adaptive.

  15. Cold bending of 34'' OD API 5L X80 pipes; Curvamento a frio de tubos API 5L X80 de 34'' de diametro

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Ronaldo; Moreira, Fabio A.; Chad, Luis; Fritz, Marcelo C. [TenarisConfab, Pindamonhangaba, SP (Brazil); Batista, Gilmar Z.; Hippert, Eduardo [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

    2008-07-01

    A key factor that demands special attention in the pipeline construction is the cold bending process, since 30 to 40% of the pipes use this process in the field. This study aimed to evaluate the X80 cold bending operational parameters, in order make viable the use of this process in the installation of future onshore pipelines. Three 34''OD x 0,750'' pipes were bended. The bending was conducted using a hydraulic equipment with application of equally spaced punches, recording the correspondent angles related to the elastic and plastic deformations in order to assess the spring-back effect and performing dimensional inspection. Samples from pipe and the weld were subjected to mechanical and metallographic tests. It was possible to obtain a 19 deg curve and 27D radius without presenting any evidence of wrinkles, out of roundness or any type of mechanical damage. After analysis, all criteria established from project specifications were complied, the mechanical tests performed allowed comparing pipe mechanical properties of straight and bended regions. The results of this study provide technical know how for future X80 onshore pipelines applications. (author)

  16. Intro to the Zotero API

    OpenAIRE

    Amanda Morton

    2013-01-01

    In this lesson, you’ll learn how to use python with the Zotero API to interact with your Zotero library. The Zotero API is a powerful interface that would allow you to build a complete Zotero client from scratch if you so desired. But like most APIs, it works in small, discrete steps, so we have to build our way up to the complicated requests we might want to use to access our Zotero libraries. But this incremental building gives us plenty of time to learn as we go along.

  17. Intro to the Zotero API

    Directory of Open Access Journals (Sweden)

    Amanda Morton

    2013-04-01

    Full Text Available In this lesson, you’ll learn how to use python with the Zotero API to interact with your Zotero library. The Zotero API is a powerful interface that would allow you to build a complete Zotero client from scratch if you so desired. But like most APIs, it works in small, discrete steps, so we have to build our way up to the complicated requests we might want to use to access our Zotero libraries. But this incremental building gives us plenty of time to learn as we go along.

  18. Dolor mandibular de origen cardíaco

    OpenAIRE

    MR Sáez Yuguero; A Bermejo Fenoll; JL Calvo Guirado; E. Álvarez Martínez

    2003-01-01

    En las complejas estructuras anatómicas orofaciales, asientan muchos procesos dolorosos. Las algias orofaciales más comunes tienen su origen a nivel dental, periodontal o en estructuras musculoesqueleticas. Sin embargo, el paciente puede manifestar dolor en esta región, bien en dientes o estructuras musculoesqueleticas, y la fuente originaria localizarse a distancia. A este tipo de dolor se le llama dolor heterotópico. Una posible fuente de dolor heterotópico es el dolor de origen cardíaco. E...

  19. MODELO ACO PARA LA RECOLECCIÓN DE RESIDUOS POR CONTENEDORES ACO MODEL APPLIED TO THE WASTE COLLECTION BY CONTAINERS

    Directory of Open Access Journals (Sweden)

    Eduardo Salazar Hornig

    2009-08-01

    Full Text Available ACO es una metaheurística inspirada en el comportamiento de las colonias de hormigas para solucionar problemas de optimización combinatoria, por medio de la utilización de agentes computacionales simples que trabajan de manera cooperativa y se comunican mediante rastros de feromona artificiales. En este trabajo se presenta un modelo para resolver el Problema de Recolección de Residuos Domiciliarios por Contenedores, el que aplica un concepto de secuencias parciales de recolección que deben ser unidas para minimizar la distancia total de recolección. El problema de unir las secuencias parciales se representa como un TSP, el que es resuelto mediante un algoritmo ACO. En base a recomendaciones de la literatura, se calibran experimentalmente los parámetros del algoritmo y se recomiendan rangos de valores que representan buenos rendimientos promedio. El modelo se aplica a un sector de recolección de la comuna de San Pedro de la Paz, Chile, obteniéndose rutas de recolección que reducen la distancia total recorrida respecto de la actual ruta utilizada y de la solución obtenida con otro modelo desarrollado previamente.ACO is a metaheuristic inspired in the behavior of natural ant colonies to solve combinatorial optimization problems, based on simple agents that work cooperatively communicating by artificial pheromone trails. In this paper a model to solve the municipal waste collection problem by containers is presented, which applies a concept of partial collection sequences that must be joined to minimize the total collection distance. The problem to join the partial collection sequences is represented as a TSP, which is solved by an ACO algorithm. Based on the literature, algorithm parameters are experimentally calibrated and range of variations that represents good average solutions are recommended. The model is applied to a waste collection sector of the San Pedro de la Paz commune in Chile, obtaining recollection routes with less total

  20. Report on the 10th International Conference of the Asian Clinical Oncology Society (ACOS 2012).

    Science.gov (United States)

    Kim, Yeul Hong; Yang, Han-Kwang; Kim, Tae Won; Lee, Jung Shin; Seong, Jinsil; Lee, Woo Yong; Ahn, Yong Chan; Lim, Ho Yeong; Won, Jong-Ho; Park, Kyong Hwa; Cho, Kyung Sam

    2013-04-01

    The 10th International Conference of the Asian Clinical Oncology Society (ACOS 2012) in conjunction with the 38th Annual Meeting of the Korean Cancer Association, was held on June 13 to 15 (3 days) 2012 at COEX Convention and Exhibition Center in Seoul, Korea. ACOS has a 20-year history starting from the first conference in Osaka, Japan, which was chaired by Prof. Tetsuo Taguchi and the ACOS conferences have since been conducted in Asian countries every 2 years. Under the theme of "Work Together to Make a Difference for Cancer Therapy in Asia", the 10th ACOS was prepared to discuss various subjects through a high-quality academic program, exhibition, and social events. The ACOS 2012 Committee was composed of the ACOS Organizing Committee, Honorary Advisors, Local Advisors, and ACOS 2012 Organizing Committee. The comprehensive academic program had a total of 92 sessions (3 Plenary Lectures, 1 Award Lectures, 1 Memorial Lectures, 9 Special Lectures, 15 Symposia, 1 Debate & Summary Sessions, 1 Case Conferences, 19 Educational Lectures, 1 Research & Development Session, 18 Satellite Symposia, 9 Meet the Professors, 14 Oral Presentations) and a total 292 presentations were delivered throughout the entire program. Amongst Free Papers, 462 research papers (110 oral presentations and 352 poster presentations) were selected to be presented. This conference was the largest of all ACOS conferences in its scale with around 1,500 participants from 30 countries. Furthermore, despite strict new financial policies and requirements governing fundraising alongside global economic stagnation, a total of 14 companies participated as sponsors and an additional 35 companies purchased 76 exhibition booths. Lastly, the conference social events provided attendees with a variety of opportunities to experience and enjoy Korea's rich culture and traditions during the Opening Ceremony, Welcome Reception, Invitee Dinner, Banquet, and Closing Ceremony. Overall, ACOS 2012 reinforced and promoted

  1. USAJOBS Job Opportunity Announcements (JOA) REST API

    Data.gov (United States)

    Office of Personnel Management — This REST-based API is designed to support lightweight Federal Job Opportunity Announcement (JOA) content consumption by consumers. It is anticipated that this API...

  2. USAJOBS Job Opportunity Announcements (JOA) SOAP API

    Data.gov (United States)

    Office of Personnel Management — The purpose of the SOAP based API is to provide the full Federal Job Opportunity Announcement (JOA) content to the consumer. It is anticipated that this API will be...

  3. Automated Ply Inspection (API) for AFP Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Automated Ply Inspection (API) system autonomously inspects layups created by high speed automated fiber placement (AFP) machines. API comprises a high accuracy...

  4. Hospitals Participating In ACOs Tend To Be Large And Urban, Allowing Access To Capital And Data.

    Science.gov (United States)

    Colla, Carrie H; Lewis, Valerie A; Tierney, Emily; Muhlestein, David B

    2016-03-01

    Relationships between physicians and hospitals have changed considerably over the past decade, as hospitals and physician groups have integrated and new public and private payment policies have created financial interdependence. The extent to which accountable care organizations (ACOs) involve hospitals in their operations may prove to be vitally important, because managing hospital care is a key part of improving health care quality and lowering cost growth. Using primary data on ACO composition and capabilities paired with hospital characteristics, we found that 20 percent of US hospitals were part of an ACO in 2014. Hospitals that were in urban areas, were nonprofit, or had a smaller share of Medicare patients were more likely to participate in ACOs, compared to hospitals that were in more rural areas, were for-profit or government owned, or had a larger share of Medicare patients, respectively. Qualitative data identified the following advantages of including a hospital in an ACO: the availability of start-up capital, advanced data sharing, and engagement of providers across the care continuum. Although the 63 percent of ACOs that included hospitals offered more comprehensive services compared to ACOs without hospitals, we found no differences between the two groups in their ability to manage hospital-related aspects of patient care.

  5. Physicians' Participation In ACOs Is Lower In Places With Vulnerable Populations Than In More Affluent Communities.

    Science.gov (United States)

    Yasaitis, Laura C; Pajerowski, William; Polsky, Daniel; Werner, Rachel M

    2016-08-01

    Early evidence suggested that accountable care organizations (ACOs) could improve health care quality while constraining costs, and ACOs are expanding throughout the United States. However, if disadvantaged patients have unequal access to physicians who participate in ACOs, that expansion may exacerbate health care disparities. We examined the relationship between physicians' participation in both Medicare and commercial ACOs across the country and the sociodemographic characteristics of their likely patient populations. Physicians' participation in ACOs varied widely across hospital referral regions, from nearly 0 percent to over 85 percent. After we adjusted for individual physician and practice characteristics, we found that physicians who practiced in ZIP Code Tabulation Areas where a higher percentage of the population was black, living in poverty, uninsured, or disabled or had less than a high school education-compared to other areas-had significantly lower rates of ACO participation than other physicians. Our findings suggest that vulnerable populations' access to physicians participating in ACOs may not be as great as access for other groups, which could exacerbate existing disparities in health care quality. PMID:27503961

  6. Layered ACO-OFDM for intensity-modulated direct-detection optical wireless transmission.

    Science.gov (United States)

    Wang, Qi; Qian, Chen; Guo, Xuhan; Wang, Zhaocheng; Cunningham, David G; White, Ian H

    2015-05-01

    Layered asymmetrically clipped optical orthogonal frequency division multiplexing (ACO-OFDM) with high spectral efficiency is proposed in this paper for optical wireless transmission employing intensity modulation with direct detection. In contrast to the conventional ACO-OFDM, which only utilizes odd subcarriers for modulation, leading to an obvious spectral efficiency loss, in layered ACO-OFDM, the subcarriers are divided into different layers and modulated by different kinds of ACO-OFDM, which are combined for simultaneous transmission. In this way, more subcarriers are used for data transmission and the spectral efficiency is improved. An iterative receiver is also proposed for layered ACO-OFDM, where the negative clipping distortion of each layer is subtracted once it is detected so that the signals from different layers can be recovered. Theoretical analysis shows that the proposed scheme can improve the spectral efficiency by up to 2 times compared with conventional ACO-OFDM approaches with the same modulation order. Meanwhile, simulation results confirm a considerable signal-to-noise ratio gain over ACO-OFDM at the same spectral efficiency. PMID:25969323

  7. MOEA/D-ACO: a multiobjective evolutionary algorithm using decomposition and AntColony.

    Science.gov (United States)

    Ke, Liangjun; Zhang, Qingfu; Battiti, Roberto

    2013-12-01

    Combining ant colony optimization (ACO) and the multiobjective evolutionary algorithm (EA) based on decomposition (MOEA/D), this paper proposes a multiobjective EA, i.e., MOEA/D-ACO. Following other MOEA/D-like algorithms, MOEA/D-ACO decomposes a multiobjective optimization problem into a number of single-objective optimization problems. Each ant (i.e., agent) is responsible for solving one subproblem. All the ants are divided into a few groups, and each ant has several neighboring ants. An ant group maintains a pheromone matrix, and an individual ant has a heuristic information matrix. During the search, each ant also records the best solution found so far for its subproblem. To construct a new solution, an ant combines information from its group's pheromone matrix, its own heuristic information matrix, and its current solution. An ant checks the new solutions constructed by itself and its neighbors, and updates its current solution if it has found a better one in terms of its own objective. Extensive experiments have been conducted in this paper to study and compare MOEA/D-ACO with other algorithms on two sets of test problems. On the multiobjective 0-1 knapsack problem,MOEA/D-ACO outperforms the MOEA/D with conventional genetic operators and local search on all the nine test instances. We also demonstrate that the heuristic information matrices in MOEA/D-ACO are crucial to the good performance of MOEA/D-ACO for the knapsack problem. On the biobjective traveling salesman problem, MOEA/D-ACO performs much better than the BicriterionAnt on all the 12 test instances. We also evaluate the effects of grouping, neighborhood, and the location information of current solutions on the performance of MOEA/D-ACO. The work in this paper shows that reactive search optimization scheme, i.e., the "learning while optimizing" principle, is effective in improving multiobjective optimization algorithms. PMID:23757576

  8. Methodology to Optimize Manufacturing Time for a CNC Using a High Performance Implementation of ACO

    Directory of Open Access Journals (Sweden)

    Oscar Montiel-Ross

    2012-10-01

    Full Text Available In this paper, an efficient methodology to generate optimal and/or quasi‐optimal sequences of G commands to minimize the manufacturing time is presented. Our solution starts from original G codes provided by application CAD/CAM software. Here, first we tackled the problem of reducing the time of the travel path for drilling of an industrial robotic manufacturing machine. The methodology can be easily implemented for free distribution or commercial CAD/CAM software without achieving any modification to it. Several experiments that demonstrate how this proposal can help to outperform solutions provided by application software are presented, consistent improvements around 62% were obtained. Moreover, for optimizing the time along the travel path, we present a high performance implementation of Ant Colonies (ACO known as Parallel ACO (P‐ACO that allows achieving the optimization task efficiently by speeding up the original ACO. A Graphical User Interface that integrates the whole process is shown.

  9. The Impact Of Medicare ACOs On Improving Integration And Coordination Of Physical And Behavioral Health Care.

    Science.gov (United States)

    Fullerton, Catherine A; Henke, Rachel M; Crable, Erica; Hohlbauch, Andriana; Cummings, Nicholas

    2016-07-01

    The accountable care organization (ACO) model holds the promise of reducing costs and improving the quality of care by realigning payment incentives to focus on health outcomes instead of service volume. One key to managing the total cost of care is improving care coordination for and treatment of people with behavioral health disorders. We examined qualitative data from ninety organizations participating in Medicare ACO demonstration programs from 2012 through 2015 to determine whether and how they focused on behavioral health care. These ACOs had mixed degrees of engagement in improving behavioral health care for their populations. The biggest challenges included a lack of behavioral health care providers, data availability, and sustainable financing models. Nonetheless, we found substantial interest in integrating behavioral health care into primary care across a majority of the ACOs. PMID:27385242

  10. An ACO model for a non-stationary formulation of the single elevator problem

    OpenAIRE

    Molina, Silvia; Leguizamón, Mario Guillermo; Alba Torres, Enrique

    2007-01-01

    The Ant Colony Optimization (ACO) metaheuristic is a bio-inspired approach for hard combinatorial optimization problems for stationary and non-stationary environments. In the ACO metaheuristic, a colony of artificial ants cooperate for finding high quality solutions in a reasonable time. An interesting example of a non-stationary combinatorial optimization problem is the Multiple Elevators Problem (MEP) which consists in finding a sequence of movements for each elevator to perform in a buildi...

  11. Dolor mandibular de origen cardíaco

    Directory of Open Access Journals (Sweden)

    MR Sáez Yuguero

    2003-10-01

    Full Text Available En las complejas estructuras anatómicas orofaciales, asientan muchos procesos dolorosos. Las algias orofaciales más comunes tienen su origen a nivel dental, periodontal o en estructuras musculoesqueleticas. Sin embargo, el paciente puede manifestar dolor en esta región, bien en dientes o estructuras musculoesqueleticas, y la fuente originaria localizarse a distancia. A este tipo de dolor se le llama dolor heterotópico. Una posible fuente de dolor heterotópico es el dolor de origen cardíaco. Este articulo presenta un caso clínico en el que el dolor mandibular bilateral fue el síntoma inicial de una cardiopatía isquémica que fue erróneamente etiquetada de artrosis de la articulación temporomandibular.In the complex orofacial anatomic structures, many painful processes are felt. The most common orofacial pains have their origin at dental or periodontal level, or in muscle -skeletical structures. However, the patient can have pain in this area- either in teeth or muscle-eskeletical structures- and the originating source can be located at a distance. This type of pain is called heterotopic pain. A possible source of heterotopic pain is the pain of cardiac origin. This paper presents a clinical case in which the bilateral mandibular pain is the initial symptom of an ischemic cardiopathy that was erroneously labeled as temporomandibular arthrosis.

  12. CACONET: Ant Colony Optimization (ACO) Based Clustering Algorithm for VANET.

    Science.gov (United States)

    Aadil, Farhan; Bajwa, Khalid Bashir; Khan, Salabat; Chaudary, Nadeem Majeed; Akram, Adeel

    2016-01-01

    A vehicular ad hoc network (VANET) is a wirelessly connected network of vehicular nodes. A number of techniques, such as message ferrying, data aggregation, and vehicular node clustering aim to improve communication efficiency in VANETs. Cluster heads (CHs), selected in the process of clustering, manage inter-cluster and intra-cluster communication. The lifetime of clusters and number of CHs determines the efficiency of network. In this paper a Clustering algorithm based on Ant Colony Optimization (ACO) for VANETs (CACONET) is proposed. CACONET forms optimized clusters for robust communication. CACONET is compared empirically with state-of-the-art baseline techniques like Multi-Objective Particle Swarm Optimization (MOPSO) and Comprehensive Learning Particle Swarm Optimization (CLPSO). Experiments varying the grid size of the network, the transmission range of nodes, and number of nodes in the network were performed to evaluate the comparative effectiveness of these algorithms. For optimized clustering, the parameters considered are the transmission range, direction and speed of the nodes. The results indicate that CACONET significantly outperforms MOPSO and CLPSO. PMID:27149517

  13. BusinessUSA Resource Access API

    Data.gov (United States)

    General Services Administration — BusinessUSA connects businesses to government services and information. The API provides access to resource abstracts including programs, services, data, events,...

  14. RNA interference of 1-aminocyclopropane-1-carboxylic acid oxidase (ACO1 and ACO2) genes expression prolongs the shelf life of Eksotika (Carica papaya L.) papaya fruit.

    Science.gov (United States)

    Sekeli, Rogayah; Abdullah, Janna Ong; Namasivayam, Parameswari; Muda, Pauziah; Abu Bakar, Umi Kalsom; Yeong, Wee Chien; Pillai, Vilasini

    2014-06-19

    The purpose of this study was to evaluate the effectiveness of using RNA interference in down regulating the expression of 1-aminocyclopropane-1-carboxylic acid oxidase gene in Eksotika papaya. One-month old embryogenic calli were separately transformed with Agrobacterium strain LBA 4404 harbouring the three different RNAi pOpOff2 constructs bearing the 1-aminocyclopropane-1-carboxylic acid oxidase gene. A total of 176 putative transformed lines were produced from 15,000 calli transformed, selected, then regenerated on medium supplemented with kanamycin. Integration and expression of the targeted gene in putatively transformed lines were verified by PCR and real-time RT-PCR. Confined field evaluation of a total of 31 putative transgenic lines planted showed a knockdown expression of the targeted ACO1 and ACO2 genes in 13 lines, which required more than 8 days to achieve the full yellow colour (Index 6). Fruits harvested from lines pRNAiACO2 L2-9 and pRNAiACO1 L2 exhibited about 20 and 14 days extended post-harvest shelf life to reach Index 6, respectively. The total soluble solids contents of the fruits ranged from 11 to 14° Brix, a range similar to fruits from non-transformed, wild type seed-derived plants.

  15. RNA Interference of 1-Aminocyclopropane-1-carboxylic Acid Oxidase (ACO1 and ACO2 Genes Expression Prolongs the Shelf Life of Eksotika (Carica papaya L. Papaya Fruit

    Directory of Open Access Journals (Sweden)

    Rogayah Sekeli

    2014-06-01

    Full Text Available The purpose of this study was to evaluate the effectiveness of using RNA interference in down regulating the expression of 1-aminocyclopropane-1-carboxylic acid oxidase gene in Eksotika papaya. One-month old embryogenic calli were separately transformed with Agrobacterium strain LBA 4404 harbouring the three different RNAi pOpOff2 constructs bearing the 1-aminocyclopropane-1-carboxylic acid oxidase gene. A total of 176 putative transformed lines were produced from 15,000 calli transformed, selected, then regenerated on medium supplemented with kanamycin. Integration and expression of the targeted gene in putatively transformed lines were verified by PCR and real-time RT-PCR. Confined field evaluation of a total of 31 putative transgenic lines planted showed a knockdown expression of the targeted ACO1 and ACO2 genes in 13 lines, which required more than 8 days to achieve the full yellow colour (Index 6. Fruits harvested from lines pRNAiACO2 L2-9 and pRNAiACO1 L2 exhibited about 20 and 14 days extended post-harvest shelf life to reach Index 6, respectively. The total soluble solids contents of the fruits ranged from 11 to 14° Brix, a range similar to fruits from non-transformed, wild type seed-derived plants.

  16. MGA trajectory planning with an ACO-inspired algorithm

    Science.gov (United States)

    Ceriotti, Matteo; Vasile, Massimiliano

    2010-11-01

    Given a set of celestial bodies, the problem of finding an optimal sequence of swing-bys, deep space manoeuvres (DSM) and transfer arcs connecting the elements of the set is combinatorial in nature. The number of possible paths grows exponentially with the number of celestial bodies. Therefore, the design of an optimal multiple gravity assist (MGA) trajectory is a NP-hard mixed combinatorial-continuous problem. Its automated solution would greatly improve the design of future space missions, allowing the assessment of a large number of alternative mission options in a short time. This work proposes to formulate the complete automated design of a multiple gravity assist trajectory as an autonomous planning and scheduling problem. The resulting scheduled plan will provide the optimal planetary sequence and a good estimation of the set of associated optimal trajectories. The trajectory model consists of a sequence of celestial bodies connected by two-dimensional transfer arcs containing one DSM. For each transfer arc, the position of the planet and the spacecraft, at the time of arrival, are matched by varying the pericentre of the preceding swing-by, or the magnitude of the launch excess velocity, for the first arc. For each departure date, this model generates a full tree of possible transfers from the departure to the destination planet. Each leaf of the tree represents a planetary encounter and a possible way to reach that planet. An algorithm inspired by ant colony optimization (ACO) is devised to explore the space of possible plans. The ants explore the tree from departure to destination adding one node at the time: every time an ant is at a node, a probability function is used to select a feasible direction. This approach to automatic trajectory planning is applied to the design of optimal transfers to Saturn and among the Galilean moons of Jupiter. Solutions are compared to those found through more traditional genetic-algorithm techniques.

  17. Validation of the Parlay API through prototyping

    NARCIS (Netherlands)

    Hellenthal, J.W.; Planken, F.J.M.; Wegdam, M.

    2001-01-01

    The desire within the telecommunications world for new and faster business growth has been a major drive towards the development of open network API. Over the past 7 years several (semi) standardization groups have announced work on network API, including TINA-C, JAIN, IEEE P1520, INforum, 3GPP, JAI

  18. Regulation of Propylene and 1-Methylcyclopropene on Expressions of ACS and ACO Genes in Persimmon Fruits

    Institute of Scientific and Technical Information of China (English)

    LIU Le; RAO Jing-ping; CHANG Xiao-xiao; YI Shun-chao

    2009-01-01

    The regulation of postharvest treatment with propylene and 1-MCP on ethylene release rate and expressions of 1-aminocyclopropane-1-carboxylic acid synthase (ACS) and 1-aminocyclopropane-1-carboxylic acid oxidase (ACO) genes in Fuping Janshi persimmon (Diospyros kaki L.) fruit were investigated. Fruits were treated with propylene and 1-MCP, then stored at 20℃, ethylene release rate of the treated fruits was measured at regular intervals and RNA was extracted for Northern blotting analysis. The results suggested that treatment with propylene accelerated the expressions of ACS and ACO genes and then enhanced the ethylene biosynthesis, while treatment with 1-MCP inhibited the expressions of two genes and their ethylene biosynthesis. Furthermore, different effects on expressions caused by treatments with propylene and 1-MCP existed in various fruit tissues, the inhibitory effect on ACS and ACO genes by 1-MCP was the strongest in pericarp, followed by pulp and core tissues, in the area near fruit stalk, the inhibitory effect was the weakest. While the enhanced effect on ACS and ACO genes by propylene increased from pulp, core, and pericarp to the area near fruit stalk. Expression of each member of ACS and ACO families in various tissues was also completely different, in control and propylene treatment, DKACS3 gene just expressed in the area near fruit stalk and did not express in other tissues, but DKACS2 gene expressed in four tissues by treatment with propylene.

  19. API Requirements for Dynamic Graph Prediction

    Energy Technology Data Exchange (ETDEWEB)

    Gallagher, B; Eliassi-Rad, T

    2006-10-13

    Given a large-scale time-evolving multi-modal and multi-relational complex network (a.k.a., a large-scale dynamic semantic graph), we want to implement algorithms that discover patterns of activities on the graph and learn predictive models of those discovered patterns. This document outlines the application programming interface (API) requirements for fast prototyping of feature extraction, learning, and prediction algorithms on large dynamic semantic graphs. Since our algorithms must operate on large-scale dynamic semantic graphs, we have chosen to use the graph API developed in the CASC Complex Networks Project. This API is supported on the back end by a semantic graph database (developed by Scott Kohn and his team). The advantages of using this API are (i) we have full-control of its development and (ii) the current API meets almost all of the requirements outlined in this document.

  20. Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): current literature review

    Science.gov (United States)

    Papaiwannou, Antonis; Porpodis, Konstantinos; Spyratos, Dionysios; Kioumis, Ioannis; Pitsiou, Georgia; Pataka, Athanasia; Tsakiridis, Kosmas; Arikas, Stamatis; Mpakas, Andreas; Tsiouda, Theodora; Katsikogiannis, Nikolaos; Kougioumtzi, Ioanna; Machairiotis, Nikolaos; Siminelakis, Stavros; Kolettas, Alexander; Kessis, George; Beleveslis, Thomas; Zarogoulidis, Konstantinos

    2014-01-01

    Asthma and chronic obstructive pulmonary disease (COPD) are chronic diseases, very common in general population. These obstructive airway illnesses are manifested with chronic inflammation affecting the whole respiratory tract. Obstruction is usually intermittent and reversible in asthma, but is progressive and irreversible in COPD. Asthma and COPD may overlap and converge, especially in older people [overlap syndrome—asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS)]. Although ACOS accounts approximately 15-25% of the obstructive airway diseases, is not well recognised because of the structure of clinical trials. COPD studies exclude asthma patients and asthma studies exclude COPD patients, respectively. It is crucial to define asthma, COPD and overlap syndrome (ACOS), as notable clinical entities, which they share common pathologic and functional features, but they are characterized from differences in lung function, acute exacerbations, quality of life, hospital impact and mortality. PMID:24672688

  1. Relative Study of CGS with ACO and BCO Swarm Intelligence Techniques

    Directory of Open Access Journals (Sweden)

    T.Hashni

    2012-09-01

    Full Text Available Swarm intelligence is the collective-level, problem-solving behavior of groups of relatively simple agents.Local interactions among agents, either direct or indirect through the environment, are fundamental for theemergence of swarm intelligence. Ant Colony Optimization (ACO is a swarm based meta-heuristic method that isinspired by the behavior of real ant colonies. Bee Colony Optimization (BCO meta-heuristic belongs to the groupof Swarm Intelligence techniques. Consultant Guided Search (CGS is a new hybrid meta heuristic, which combinesnew ideas with concepts found in Ant colony Optimization (ACO, Bee Colony Optimization (BCO technique. Thispaper presents comparative study of CGS, ACO, BCO techniques and the flexibility of CGS.

  2. Web API Growing Pains: Loosely Coupled yet Strongly Tied

    NARCIS (Netherlands)

    Espinha, T.; Zaidman, A.; Gross, H.G.

    2014-01-01

    Web APIs provide a systematic and extensible approach for application-toapplication interaction. Developers using web APIs are forced to accompany the API providers in their software evolution tasks. In order to understand the distress caused by this imposition on web API client developers we perfor

  3. An improved adaptive ACO meta heuristic for scheduling multimedia traffic across the 802.11e EDCA

    Science.gov (United States)

    Ditze, Michael; Becker, Markus

    2008-01-01

    This paper presents an adaptive near-optimal scheduler for multimedia traffic for the 802.11e Enhanced Distributed Channel Access (EDCA) medium access control scheme. The scheduler exploits the ant colony optimization (ACO) meta heuristic to tackle the challenge of packet scheduling. ACO is a biologically inspired algorithm that is known to find near-optimal solutions for combinatorial optimization problems. Thus, we expect that ACO scheduling produces more efficient schedules than comparable deterministic scheduling approaches at the expenses of a computational overhead it introduces. We compare ACO scheduling relevant deterministic scheduling approaches, and in particular the MLLF scheduler that is specifically designed for the needs of compressed multimedia applications. The purpose of the evaluation is twofold. It allows to draw conclusions on the feasibility of ACO scheduling for multimedia traffic while it serves as a benchmark to determine to what extent deterministic schedulers fall short of a near-optimal solution.

  4. DySectAPI: Scalable Prescriptive Debugging

    DEFF Research Database (Denmark)

    Jensen, Nicklas Bo; Karlsson, Sven; Quarfot Nielsen, Niklas;

    We present the DySectAPI, a tool that allow users to construct probe trees for automatic, event-driven debugging at scale. The traditional, interactive debugging model, whereby users manually step through and inspect their application, does not scale well even for current supercomputers. While...... lightweight debugging models scale well, they can currently only debug a subset of bug classes. DySectAPI fills the gap between these two approaches with a novel user-guided approach. Using both experimental results and analytical modeling we show how DySectAPI scales and can run with a low overhead...

  5. The JANA Calibrations and Conditions Database API

    Energy Technology Data Exchange (ETDEWEB)

    David Lawrence

    2010-07-01

    Calibrations and conditions databases can be accessed from within the JANA Event Processing framework through the API defined in its JCalibration base class. The API is designed to support everything from databases, to web services to flat files for the backend. A Web Service backend using the gSOAP toolkit has been implemented which is particularly interesting since it addresses many modern cybersecurity issues including support for SSL. The API allows constants to be retrieved through a single line of C++ code with most of the context, including the transport mechanism, being implied by the run currently being analyzed and the environment relieving developers from implementing such details.

  6. Internet SCADA Utilizing API's as Data Source

    Science.gov (United States)

    Robles, Rosslin John; Kim, Haeng-Kon; Kim, Tai-Hoon

    An Application programming interface or API is an interface implemented by a software program that enables it to interact with other software. Many companies provide free API services which can be utilized in Control Systems. SCADA is an example of a control system and it is a system that collects data from various sensors at a factory, plant or in other remote locations and then sends this data to a central computer which then manages and controls the data. In this paper, we designed a scheme for Weather Condition in Internet SCADA Environment utilizing data from external API services. The scheme was designed to double check the weather information in SCADA.

  7. Hydrogen Sulfide Corrosion of Weld Regions in API X52 Steel

    Directory of Open Access Journals (Sweden)

    García-Cerecero G.

    2012-10-01

    Full Text Available The corrosion behavior of gas metal arc welding (GMAW regions has been studied using potentiodynamic polarization and polarization resistance (LPR techniques. Experiments were conducted in hydrogen sulfide (H2S-containing brine and in H2S-free brine. Welds were made on API 5L X52 steel. Due to differences in their microstructure, chemical composition and residual stress level, weld regions exhibited different responses under H2S corrosion. Base metal exhibited the highest corrosion rate (CR and the most cathodic corrosion potential.

  8. Webometrische Analysen mit Hilfe der Google Web APIs

    OpenAIRE

    Mayr, Philipp; Tosques, Fabio

    2005-01-01

    This report describes possibilities and restrictions of the Google Web APIs (Google API). The implementation of the Google API in the context of information science studies from the webometrics field shows, that the Google API can be used with restrictions for internet based studies. The comparison of hit results from the two Google interfaces Google API and the standard web interface Google.com (Google Web) shows differences concerning range, structure und availability. The study bases on si...

  9. ChemSpell Web Service API

    Data.gov (United States)

    U.S. Department of Health & Human Services — The ChemSpell Web Service API provides chemical name spell checking and chemical name synonym look-up. ChemSpell contains more than 1.3 million chemical names...

  10. Real World Uses For Nagios APIs

    Science.gov (United States)

    Singh, Janice

    2014-01-01

    This presentation describes the Nagios 4 APIs and how the NASA Advanced Supercomputing at Ames Research Center is employing them to upgrade its graphical status display (the HUD) and explain why it's worth trying to use them yourselves.

  11. System for Award Management (SAM) API

    Data.gov (United States)

    General Services Administration — The SAM API is a RESTful method of retrieving public information about the businesses, organizations, or individuals (referred to as entities) within the SAM entity...

  12. (H)appiness is a warm API!

    OpenAIRE

    Pattern, David

    2012-01-01

    Presentation given at the Internet Librarian International Conference 2012, Olympia Conference Centre, London, UK. The presentation discusses how Application Programming Interfaces (APIs) were used to help develop MyReading, the reading list software used by the University of Huddersfield.

  13. BeXRB Monitor Data API

    Data.gov (United States)

    National Aeronautics and Space Administration — A fully queryable REST API with JSON, XML, and CSV output as well as inline, runable examples. This is a monitor using data from Swift/BAT, MAXI and Fermi/GBM...

  14. Postharvest Analysis of Lowland Transgenic Tomato Fruits Harboring hpRNAi-ACO1 Construct

    Directory of Open Access Journals (Sweden)

    Bita Behboodian

    2012-01-01

    Full Text Available The plant hormone, ethylene, is an important regulator which involved in regulating fruit ripening and flower senescence. In this study, RNA interference (RNAi technology was employed to silence the genes involved in ethylene biosynthetic pathway. This was achieved by blocking the expression of specific gene encoding the ACC oxidase. Initially, cDNA corresponding to ACO1 of lowland tomato cultivar (MT1, which has high identity with ACO1 of Solanum lycopersicum in GenBank, was cloned through RT-PCR. Using a partial coding region of ACO1, one hpRNAi transformation vector was constructed and expressed ectopically under the 35S promoter. Results showed that transgenic lines harboring the hpRNA-ACO1 construct had lower ethylene production and a longer shelf life of 32 days as compared to 10 days for wild-type fruits. Changes in cell wall degrading enzyme activities were also investigated in cases where the transgenic fruits exhibited reduced rates of firmness loss, which can be associated with a decrease in pectin methylesterase (PME and polygalacturonase (PG activities. However, no significant change was detected in both transgenic and wild-type fruits in terms of β-galactosidase (β-Gal activity and levels of total soluble solid, titratable acid and ascorbic acid.

  15. APIs and Researchers: The Emperor's New Clothes?

    Directory of Open Access Journals (Sweden)

    Jennifer Edmond

    2015-02-01

    Full Text Available As part of the Europeana Cloud (eCloud project, Trinity College Dublin investigated best practice in the use of web services, such as APIs, for accessing large data sets from cultural heritage collections. This research looked into the provision and use of APIs, and moreover, whether or not more customised programmatic access to datasets is what researchers want or need. In order to understand whether current patterns of API usage reflect a skills gap on the part of researchers or a mismatch of tool to purpose, we looked not only at the creators and developer/users of APIs, but also at humanists already re-using big data; approaches in cultural heritage institutions and other research infrastructures to bring API use to non-technical audiences; and the kinds of training and other support services available or emerging within the data-intensive humanities research lifecycle. We conducted both desk research and a series of 11 interviews with figures working as researchers, developers or data providers, including figures from both the API development and the data usage communities. This research, conducted under the eCloud project and supported by the European Commission’s ICT Policy and Support Programme (Grant number 325091, was begun in March 2014 and is now in its concluding validation stage. The results of the research are not yet finalised, but the contribution is already emerging of this work to the debate about APIs being either the way forward for digital cultural heritage collections, or the Emperor’s New Clothes (or maybe a bit of both.

  16. Comparative Foraging Behavior of Apis Cerana F. and Apis Mellifera L. in Rapeseed under Cage Condition in Chitwan, Nepal

    Directory of Open Access Journals (Sweden)

    Rameshwor Pudasaini

    2014-12-01

    Full Text Available An experiment was conducted to determine the foraging behavior of Apis mellifera L. and Apis cerana F. in rapeseed under cage condition in Chitwan, Nepal during 2012-2013. This experiment showed that Apis cerana F. foraged extra 42 minute per day as compared to Apis mellifera L. Apis cerana F. were more attracted to nectar, whereas Apis mellifera L. were more attracted to pollen collection throughout the day. The activities, in into hives and out from hives, for both species were recorded more at 2:00 pm and least at 8:00 am. The highest in-out were observed at 2:00 pm on both species as Apis mellifera L. 44.33 bees entered into hives and 49.66 bees went out of hives, whereas lower number of Apis cerana F. 43.66 bees entered into hives and 48.16 bees were out of hives. Apis mellifera L. collect 1.22:1 and 0.41:1 pollen nectar ratio at 10:00 am and 4:00 am whereas at same hours Apis cerana collect 1.16:1 and 0.30:1 pollen nectar ratio. Apis cerana F. foraged significantly higher number of rapeseed flowers and plants as compared to Apis mellifera L. under caged condition. It shows that Apis cerana F. was more efficient pollinator as compared to Apis mellifera L. under caged condition.

  17. Characterisation of weldment hardness, impact energy and microstructure in API X65 steel

    International Nuclear Information System (INIS)

    The variation of microstructure and mechanical properties in various sub-zones of double submerged arc welded line pipe steel of grade API X65 was investigated. Instrumented Charpy V-notch tests and Vickers hardness experiments were conducted on the fusion zone, base metal and heat affected zone of the weld joint in 14.3 mm thick, 1219 mm outside diameter spiral pipeline. The lowest impact energy and the highest hardness level (160J and 218 HV, respectively) were recorded in the fusion zone. The low energy and high hardness characteristics of the seam weld can be attributed to its cast microstructure and the presence of grain boundary phases (such as proeutectoid ferrite), confirmed by standard metallographic observation. Despite this, service requirements set by the API 5L industry code (minimum impact energy of 73J, maximum hard spots of 350 HV) were fulfilled by the tested steel. Highlights: ► Experimental study of API X65 steel microstructure. ► Analysis of the relationship between X65 steel microstructure and hardness. ► Analysis of the relationship between X65 steel microstructure and impact energy. ► Presentation of detailed technical information on DSA welding in spiral pipes.

  18. CALIBRATION, OPTIMIZATION, AND SENSITIVITY AND UNCERTAINTY ALGORITHMS APPLICATION PROGRAMMING INTERFACE (COSU-API)

    Science.gov (United States)

    The Application Programming Interface (API) for Uncertainty Analysis, Sensitivity Analysis, and Parameter Estimation (UA/SA/PE API) tool development, here fore referred to as the Calibration, Optimization, and Sensitivity and Uncertainty Algorithms API (COSU-API), was initially d...

  19. Advanced API security securing APIs with OAuth 2.0, OpenID Connect, JWS, and JWE

    CERN Document Server

    Siriwardena, Prabath

    2014-01-01

    Advanced API Security is a complete reference to the next wave of challenges in enterprise security--securing public and private APIs. API adoption in both consumer and enterprises has gone beyond predictions. It has become the 'coolest' way of exposing business functionalities to the outside world. Both your public and private APIs, need to be protected, monitored and managed. Security is not an afterthought, but API security has evolved a lot in last five years. The growth of standards, out there, has been exponential. That's where AdvancedAPI Security comes in--to wade through the weeds

  20. Effect of natural aging on the microstructural regions, mechanical properties, corrosion resistance and fracture in welded joints on API5L X52 steel pipeline

    Directory of Open Access Journals (Sweden)

    Vargas-Arista, Benjamín

    2014-09-01

    Full Text Available A characterization study was done to analyze how microstructural regions affect the mechanical properties, corrosion and fractography of the Heat Affected Zone (HAZ, weld bead and base metal for pipe naturally aged for 21 years at 30 °C. Results showed that microstructures exhibited damage and consequently decrease in properties, resulting in over-aged due to service. SEM analysis showed that base metal presented coarse ferrite grain. Tensile test indicated that microstructures showed discontinuous yield. Higher tensile strength was obtained for weld bead, which exhibited a lower impact energy in comparison to that of HAZ and base metal associated with brittle fracture by trans-granular cleavage. The degradation of properties was associated with the coarsening of nano-carbides observed through TEM images analysis, which was confirmed by SEM fractography of tensile and impact fracture surfaces. The weld bead reached the largest void density and highest susceptibility to corrosion in H2S media when compared to those of the HAZ and base metal.Se realizó un estudio de caracterización para analizar cómo la microestructura afecta a las propiedades mecánicas, corrosión y fractura de la zona afectada por calor (ZAC, soldadura y metal base para tubería envejecida naturalmente durante 21 años a 30 °C. Los resultados indicaron que las microestructuras presentaron daño y consecuentemente reducción en propiedades mecánicas, como consecuencia del envejecimiento por servicio. El estudio mediante MEB mostró que el metal base presenta grano ferrítico grueso. La prueba de tensión indicó que las microestructuras mostraron fluencia discontinua. La mayor resistencia a la tracción se presentó en la soldadura, la cual alcanzó menor energía de impacto en comparación con la ZAC y metal base asociado con fractura frágil por clivaje transgranular. La degradación de las propriedades está en relación con el engrosamiento de nanocarburos observados a través del análisis de imágenes por MET, lo que se confirmó mediante fractografía por MEB de superfícies de fractura bajo tensión e impacto. La soldadura alcanzó la mayor densidad de microhuecos y la mayor susceptibilidad a la corrosión en un medio conteniendo H2S que cuando se compara con la ZAC y metal base.

  1. Effect of natural aging on the microstructural regions, mechanical properties, corrosion resistance and fracture in welded joints on API5L X52 steel pipeline

    Energy Technology Data Exchange (ETDEWEB)

    Vargas-Arista, B.; Albiter, A.; Garcia-Vazquez, F.; Mendoza-Camargo, O.; Hallen, J. M.

    2014-07-01

    A characterization study was done to analyze how microstructural regions affect the mechanical properties, corrosion and fractography of the Heat Affected Zone (HAZ), weld bead and base metal for pipe naturally aged for 21 years at 30 degree centigrade. Results showed that microstructures exhibited damage and consequently decrease in properties, resulting in over-aged due to service. SEM analysis showed that base metal presented coarse ferrite grain. Tensile test indicated that microstructures showed discontinuous yield. Higher tensile strength was obtained for weld bead, which exhibited a lower impact energy in comparison to that of HAZ and base metal associated with brittle fracture by trans-granular cleavage. The degradation of properties was associated with the coarsening of nano-carbides observed through TEM images analysis, which was confirmed by SEM fractography of tensile and impact fracture surfaces. The weld bead reached the largest void density and highest susceptibility to corrosion in H{sub 2}S media when compared to those of the HAZ and base metal. (Author)

  2. Update Strength in EDAs and ACO: How to Avoid Genetic Drift

    DEFF Research Database (Denmark)

    Sudholt, Dirk; Witt, Carsten

    2016-01-01

    , there is a general trade-off: too strong updates can lead to genetic drift and poor performance. We demonstrate this trade-off for the cGA and a simple MMAS ACO algorithm on the OneMax function. More precisely, we obtain lower bounds on the expected runtime of Ω(K√n + nlogn) and Ω(√n/ρ + nlogn), respectively......We provide a rigorous runtime analysis concerning the update strength, a vital parameter in probabilistic model-building GAs such as the step size 1/K in the compact Genetic Algorithm (cGA) and the evaporation factor ρ in ACO. While a large update strength is desirable for exploitation...

  3. A Novel Framework Based on ACO and PSO for RNA Secondary Structure Prediction

    Directory of Open Access Journals (Sweden)

    Gang Wang

    2013-01-01

    Full Text Available Prediction of RNA structure is a useful process for creating new drugs and understanding genetic diseases. In this paper, we proposed a particle swarm optimization (PSO and ant colony optimization (ACO based framework (PAF for RNA secondary structure prediction. PAF consists of crucial stem searching (CSS and global sequence building (GSB. In CSS, a modified ACO (MACO is used to search the crucial stems, and then a set of stems are generated. In GSB, we used a modified PSO (MPSO to construct all the stems in one sequence. We evaluated the performance of PAF on ten sequences, which have length from 122 to 1494. We also compared the performance of PAF with the results obtained from six existing well-known methods, SARNA-Predict, RnaPredict, ACRNA, PSOfold, IPSO, and mfold. The comparison results show that PAF could not only predict structures with higher accuracy rate but also find crucial stems.

  4. New data association technique based on ACO with directional information considered

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Due to the advantages of ant colony optimization (ACO) in solving complex problems, a new data association algorithm based on ACO in a cluttered environment called DACDA is proposed. In the proposed method, the concept for tour and the length of tour are redefined. Additionally, the directional information is incorporated into the proposed method because it is one of the most important factors that affects the performance of data association. Kalraan filter is employed to estimate target states. Computer simulation results show that the proposed method could carry out data association in an acceptable CPU time, and the correct data association rate is higher than that obtained by the data association (DA) algorithm not combined with directional information.

  5. A framework for API solubility modelling

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul; Crafts, Peter

    . In addition, most of the models are not predictive and requires experimental data for the calculation of the needed parameters. This work aims at developing an efficient framework for the solubility modelling of Active Pharmaceutical Ingredients (API) in water and organic solvents. With this framework......-SAFT) are used for solubility calculations when the needed interaction parameters or experimental data are available. The CI-UNIFAC is instead used when the previous models lack interaction parameters or when solubility data are not available. A new GC+ model for APIs solvent selection based...... on the hydrophobicity, hydrophilicity and polarity information of the API and solvent is also developed, for performing fast solvent selection and screening. Eventually, all the previous developments are integrated in a framework for their efficient and integrated use. Two case studies are presented: the first...

  6. Unified Medical Language System Terminology Services (UTS) API

    Data.gov (United States)

    U.S. Department of Health & Human Services — The UTS API is intended for application developers to perform Web service calls and retrieve UMLS data within their own applications. The UTS API provides the...

  7. MODAPS Web Services API for LANCE-MODIS

    Data.gov (United States)

    National Aeronautics and Space Administration — MODAPS Web Services API for LANCE-MODIS. This Application Programming Interface (API) encompasses a library of functions that provides programmatic data access to...

  8. Comparative virulence and competition between Nosema apis and Nosema ceranae in honey bees (Apis mellifera).

    Science.gov (United States)

    Milbrath, Meghan O; van Tran, Toan; Huang, Wei-Fong; Solter, Leellen F; Tarpy, David R; Lawrence, Frank; Huang, Zachary Y

    2015-02-01

    Honey bees (Apis mellifera) are infected by two species of microsporidia: Nosema apis and Nosemaceranae. Epidemiological evidence indicates that N. ceranae may be replacing N. apis globally in A. mellifera populations, suggesting a potential competitive advantage of N. ceranae. Mixed infections of the two species occur, and little is known about the interactions among the host and the two pathogens that have allowed N. ceranae to become dominant in most geographical areas. We demonstrated that mixed Nosema species infections negatively affected honey bee survival (median survival=15-17days) more than single species infections (median survival=21days and 20days for N. apis and N. ceranae, respectively), with median survival of control bees of 27days. We found similar rates of infection (percentage of bees with active infections after inoculation) for both species in mixed infections, with N. apis having a slightly higher rate (91% compared to 86% for N. ceranae). We observed slightly higher spore counts in bees infected with N. ceranae than in bees infected with N. apis in single microsporidia infections, especially at the midpoint of infection (day 10). Bees with mixed infections of both species had higher spore counts than bees with single infections, but spore counts in mixed infections were highly variable. We did not see a competitive advantage for N. ceranae in mixed infections; N. apis spore counts were either higher or counts were similar for both species and more N. apis spores were produced in 62% of bees inoculated with equal dosages of the two microsporidian species. N. ceranae does not, therefore, appear to have a strong within-host advantage for either infectivity or spore growth, suggesting that direct competition in these worker bee mid-guts is not responsible for its apparent replacement of N. apis. PMID:25527406

  9. Experimental evaluation of a R134a/CO2 cascade refrigeration plant

    OpenAIRE

    Sanz Kock, Carlos; Llopis Doménech, Rodrigo; Sánchez García-Vacas, Daniel; Cabello López, Ramón; Torrella Alcaraz, Enrique

    2014-01-01

    We present the experimental evaluation of a R134a/CO2 cascade refrigeration plant designed for low evaporation temperature in commercial refrigeration applications. The test bench incorporates two single- stage vapour compression cycles driven by semi hermetic compressors coupled thermally through two brazed plate cascade heat exchangers working in parallel and controlled by electronic expansion valves. The experimental evaluation (45 steady-states) covers evaporating temperatures from -40 to...

  10. Relative Study of CGS with ACO and BCO Swarm Intelligence Techniques

    OpenAIRE

    T.Hashni; T Amudha

    2012-01-01

    Swarm intelligence is the collective-level, problem-solving behavior of groups of relatively simple agents.Local interactions among agents, either direct or indirect through the environment, are fundamental for theemergence of swarm intelligence. Ant Colony Optimization (ACO) is a swarm based meta-heuristic method that isinspired by the behavior of real ant colonies. Bee Colony Optimization (BCO) meta-heuristic belongs to the groupof Swarm Intelligence techniques. Consultant Guided Search (CG...

  11. Ant Colony Optimization ACO For The Traveling Salesman Problem TSP Using Partitioning

    OpenAIRE

    Alok Bajpai; Raghav Yadav

    2015-01-01

    Abstract An ant colony optimization is a technique which was introduced in 1990s and which can be applied to a variety of discrete combinatorial optimization problem and to continuous optimization. The ACO algorithm is simulated with the foraging behavior of the real ants to find the incremental solution constructions and to realize a pheromone laying-and-following mechanism. This pheromone is the indirect communication among the ants. In this paper we introduces the partitioning technique ba...

  12. Tailoring Systems Engineering Processes in a Conceptual Design Environment: A Case Study at NASA Marshall Spaceflight Center's ACO

    Science.gov (United States)

    Mulqueen, John; Maples, C. Dauphne; Fabisinski, Leo, III

    2012-01-01

    This paper provides an overview of Systems Engineering as it is applied in a conceptual design space systems department at the National Aeronautics and Space Administration (NASA) Marshall Spaceflight Center (MSFC) Advanced Concepts Office (ACO). Engineering work performed in the NASA MFSC's ACO is targeted toward the Exploratory Research and Concepts Development life cycle stages, as defined in the International Council on Systems Engineering (INCOSE) System Engineering Handbook. This paper addresses three ACO Systems Engineering tools that correspond to three INCOSE Technical Processes: Stakeholder Requirements Definition, Requirements Analysis, and Integration, as well as one Project Process Risk Management. These processes are used to facilitate, streamline, and manage systems engineering processes tailored for the earliest two life cycle stages, which is the environment in which ACO engineers work. The role of systems engineers and systems engineering as performed in ACO is explored in this paper. The need for tailoring Systems Engineering processes, tools, and products in the ever-changing engineering services ACO provides to its customers is addressed.

  13. Pro REST API development with nodejs

    CERN Document Server

    Doglio, Fernando

    2015-01-01

    Pro REST API Development with Node.js is your guide to managing and understanding the full capabilities of successful REST development. API design is a hot topic in the programming world, but not many resources exist for developers to really understand how you can leverage the advantages. This book will provide a brief background on REST and the tools it provides (well known and not so well known). Understand how there is more to REST than just JSON and URLs. You will then cover and compare the maintained modules currently available in the npm community, including Express, Restify, Vatican,

  14. Upon a Message-Oriented Trading API

    Directory of Open Access Journals (Sweden)

    Claudiu VINTE

    2010-01-01

    Full Text Available In this paper, we introduce the premises for a trading system application-programming interface (API based on a message-oriented middleware (MOM, and present the results of our research regarding the design and the implementation of a simulation-trading system employing a service-oriented architecture (SOA and messaging. Our research has been conducted with the aim of creating a simulation-trading platform, within the academic environment, that will provide both the foundation for future experiments with trading systems architectures, components, APIs, and the framework for research on trading strategies, trading algorithm design, and equity markets analysis tools. Mathematics Subject Classification: 68M14 (distributed systems.

  15. Solving optimum operation of single pump unit problem with ant colony optimization (ACO) algorithm

    International Nuclear Information System (INIS)

    For pumping stations, the effective scheduling of daily pump operations from solutions to the optimum design operation problem is one of the greatest potential areas for energy cost-savings, there are some difficulties in solving this problem with traditional optimization methods due to the multimodality of the solution region. In this case, an ACO model for optimum operation of pumping unit is proposed and the solution method by ants searching is presented by rationally setting the object function and constrained conditions. A weighted directed graph was constructed and feasible solutions may be found by iteratively searching of artificial ants, and then the optimal solution can be obtained by applying the rule of state transition and the pheromone updating. An example calculation was conducted and the minimum cost was found as 4.9979. The result of ant colony algorithm was compared with the result from dynamic programming or evolutionary solving method in commercial software under the same discrete condition. The result of ACO is better and the computing time is shorter which indicates that ACO algorithm can provide a high application value to the field of optimal operation of pumping stations and related fields.

  16. Predicting coal ash fusion temperature based on its chemical composition using ACO-BP neural network

    International Nuclear Information System (INIS)

    Coal ash fusion temperature is important to boiler designers and operators of power plants. Fusion temperature is determined by the chemical composition of coal ash, however, their relationships are not precisely known. A novel neural network, ACO-BP neural network, is used to model coal ash fusion temperature based on its chemical composition. Ant colony optimization (ACO) is an ecological system algorithm, which draws its inspiration from the foraging behavior of real ants. A three-layer network is designed with 10 hidden nodes. The oxide contents consist of the inputs of the network and the fusion temperature is the output. Data on 80 typical Chinese coal ash samples were used for training and testing. Results show that ACO-BP neural network can obtain better performance compared with empirical formulas and BP neural network. The well-trained neural network can be used as a useful tool to predict coal ash fusion temperature according to the oxide contents of the coal ash

  17. De la Locura de doble forma a la Psicosis maníaco-depresiva.

    Directory of Open Access Journals (Sweden)

    - Consejo de Redacción

    1995-01-01

    Full Text Available Sin entrar en polémicas sobre a quién atribuir la primera descripción de lo que actualmente llamamos Psicosis maníaco-depresiva, es decir, sin tomar partido por Baillarger o J.-P. Falret, lo cierto es que a mediados del pasado siglo los alienistas franceses orquestaron un saber nosológico en el que se reunían en una única categoría dos manifestaciones extremas del humor: la manía y la melancolía. Tras las descripciones fundacionales de Baillarger y de Falret, fechadas ambas en el mismo año, 1854, se abrió un espacio nosológico opuesto al terreno de los delirios crónicos: las psicosis del humor frente a las psicosis de la razón, o bien psicosis maníaco-depresiva frente a esquizofrenia-paranoia. De la última cosecha del nosógrafo por excelencia, Emil Kraepelin, proviene la descripción clínica más completa y matizada de la locura maníaco-depresiva (das manisch-depressive Irresein. Dos años después, en 1915, S. Freud mostró en Duelo y Melancolía la infraestructura metapsicológica de la manía y de la melancolía.

  18. Google Web APIs : an instrument for Webometric Analyses?

    OpenAIRE

    Mayr, Philipp

    2005-01-01

    This poster introduces Google Web APIs (Google APIs) as an instrument and playground for webometric studies. Several examples of Google APIs implementations in the context of webometrics are given. Our examples show that this Google Web Service can be used successfully for informetric Internet based studies albeit with some restrictions. E.g. we can show that hit results from the two different Google interfaces: Google APIs and the standard interface Google.com vary in range, structure und av...

  19. Google Web APIs - an Instrument for Webometric Analyses?

    OpenAIRE

    Mayr, Philipp; Tosques, Fabio

    2006-01-01

    This poster introduces Google Web APIs (Google APIs) as an instrument and playground for webometric studies. Several examples of Google APIs implementations in the context of webometrics are given. Our examples show that this Google Web Service can be used successfully for informetric Internet based studies albeit with some restrictions. E.g. we can show that hit results from the two different Google interfaces: Google APIs and the standard interface Google.com vary in range, structure und a...

  20. Uma breve revisão histórica do desenvolvimento da soldagem dos aços API para tubulações A brief history review of development on API steels welding for pipeline

    OpenAIRE

    Jaime Casanova Soeiro Junior; David Bellentani Rocha; Sérgio Duarte Brandi

    2013-01-01

    Este trabalho enfoca o desenvolvimento dos aços API para tubulações desde o aço API 5L X42, desenvolvido em 1948, através de laminação a quente seguida de tratamento térmico. Desde então foram feitos diferentes desenvolvimentos visando aumentar a resistência mecânica e a tenacidade, além de melhorar a soldabilidade. Entre eles, a adição de elementos de liga, produzindo os aços ARBL e a utilização de rotas de processamento termomecânico durante a laminação. Inicialmente a rota utilizada era a ...

  1. 47 CFR 61.46 - Adjustments to the API.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Adjustments to the API. 61.46 Section 61.46... Rules for Dominant Carriers § 61.46 Adjustments to the API. (a) Except as provided in paragraphs (d) and... carrier must calculate an API for each affected basket pursuant to the following methodology: APIt =...

  2. Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution.

    Science.gov (United States)

    Xu, Wenjuan; Jing, Linlin; Wang, Quanshi; Lin, Chung-Chih; Chen, Xiaoting; Diao, Jianxin; Liu, Yuanliang; Sun, Xuegang

    2015-10-01

    Intrinsic apoptosis eliminates cells with damaged DNA and cells with dysregulated expression of oncogene. PGAM5, a member of the phosphoglycerate mutase family, has two splicing variants: PGAM5L (the long form) and PGAM5S (the short form). It has been well established that PGAM5 is at the convergent point of multiple necrosis pathways. However, the role of PGAM5 in intrinsic apoptosis is still controversial. Here we report that the PGAM5L, but not PGAM5S is a prerequisite for the activation of Bax and dephosphorylation of Drp1 in arenobufagin and staurosporine induced intrinsic apoptosis. Knockdown of PGAM5L inhibits the translocation of Bax to the mitochondria and reduces mitochondrial fission. The interaction between PGAM5L and Drp1 was observed in both arenobufagin and staurosporine treated HCT116 cells, but not in HCT116 Bax(-/-) cells. Bax transfection rescues the formation of the triplex in both arenobufagin and staurosporine stimulated HCT116 Bax(-/-) cells. Arenobufagin shows remarkable anti-cancer effects both in orthotropic and heterotropic CRC models and demonstrates less toxic effects as compared with that of cisplatin. Bax-PGAM5L-Drp1 complex is detected in arenobufagin and staurosporine treated CRC cells in vitro and in arenobufagin and cisplatin treated tumor in vivo as well. In summary, our results demonstrate that Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution. PMID:26356820

  3. The Apis mellifera filamentous virus genome

    Science.gov (United States)

    A complete reference genome of the Apis mellifera Filamentous virus (AmFV) was determined using Illumina Hiseq sequencing. The AmFV genome is a double strand DNA molecule of approximately 498’500 nucleotides with a GC content of 50.8%. It encompasses 251 non overlapping open reading frames (ORFs), e...

  4. Standard methods for Apis mellifera propolis research

    Science.gov (United States)

    Propolis is one of the most fascinating honey bee (Apis mellifera L.) products. It is a plant derived product that bees produce from resins that they collect from different plant organs and with which they mix beeswax. Propolis is a building material and a protective agent in the beehive. It also pl...

  5. DySectAPI: Scalable Prescriptive Debugging

    DEFF Research Database (Denmark)

    Jensen, Nicklas Bo; Karlsson, Sven; Quarfot Nielsen, Niklas;

    We present the DySectAPI, a tool that allow users to construct probe trees for automatic, event-driven debugging at scale. The traditional, interactive debugging model, whereby users manually step through and inspect their application, does not scale well even for current supercomputers. While...

  6. How Do Developers Use APIs? A Case Study in Concurrency

    DEFF Research Database (Denmark)

    Blom, Stefan; Kiniry, Joseph; Huisman, Marieke

    2013-01-01

    With the omnipresent usage of APIs in software development, it has become important to analyse how the routines and functionalities of APIs are actually used. This information is in particular useful for API developers, to make decisions about future updates of the API. However, also for developers...... of static analysis and verification tools this information is highly important, because it indicates where and how to put the most efficient effort in annotating APIs, to make them usable for the static analysis and verification tools. This paper presents an analysis of the usage of the routines...

  7. Hydrogen sulfide corrosion of weld regions in API X52 steel; Corrosion por acido sulfhidrico de las regiones de soldadura en acero API X52

    Energy Technology Data Exchange (ETDEWEB)

    Arenas-Martinez, L.F [Universidad Autonoma de Coahuila, Coahuila (Mexico)]. E-mail: fernando.arenas@uadec.edu.mx; Garcia-Cerecero, G. [Corporacion Mexicana de Investigacion en Materiales S.A. de C.V., Saltillo, Coahuila (Mexico)]. E-mail: ggarcia@comimsa.com

    2012-10-15

    The corrosion behavior of gas metal arc welding (GMAW) regions has been studied using potentiodynamic polarization and polarization resistance (LPR) techniques. Experiments were conducted in hydrogen sulfide (H{sub 2}S)-containing brine and in H{sub 2}S-free brine. Welds were made on API 5L X52 steel. Due to differences in their microstructure, chemical composition and residual stress level, weld regions exhibited different responses under H{sub 2}S corrosion. Base metal exhibited the highest corrosion rate (CR) and the most cathodic corrosion potential. [Spanish] Se estudio el comportamiento ante la corrosion de las regiones de soldadura de un cordon realizado por arco metalico con gas (GMAW) sobre un acero grado API X52 mediante las tecnicas de polarizacion potencio dinamica y resistencia a la polarizacion (LPR). Los experimentos se realizaron utilizando salmuera con 300 ppm de acido sulfhidrico (H{sub 2}S) y salmuera libre de H{sub 2}S como electrolitos. Debido a las diferencias en su microestructura, composicion quimica y el nivel de esfuerzos residuales, las regiones de soldadura mostraron diferentes respuestas a la corrosion por H{sub 2}S. El metal base exhibio la velocidad de corrosion (VC) mas alta y el potencial de corrosion mas catodico.

  8. An Implementation Model of Parlay MMCCS API Based on SIP

    Institute of Scientific and Technical Information of China (English)

    GUAN You-qing; SHEN Su-bin

    2006-01-01

    Parlay Multi Media Call Control Services(MMCCS) Application Programming Interfaces (API) based on Session Initiation Protocol (SIP) is essential for the implementation of Parlay Call Control (CC) API. This paper first proposes an implementation model of Parlay MMCCS API based on SIP, then presents a mapping between SIP and MMCCS API as far as methods and parameters are concerned, illustrates corresponding relationships between different components of SIP and MMCCS API by means of an application collaboration diagram, and finally presents an application using Java codes as well as some SIP messages. The application shows that a majority of MMCCS API based on SIP can be implemented and therefore verifies our mapping between MMCCS API and SIP.

  9. Comparison of API ZYM system with API AN-Ident, API 20A, Minitek Anaerobe II, and RapID-ANA systems for identification of Clostridium difficile.

    OpenAIRE

    Head, C B; Ratnam, S

    1988-01-01

    The API ZYM system was compared with four anaerobe identification systems for the definitive identification of Clostridium difficile by using 88 cultures of C. difficile grown on Mueller-Hinton blood agar medium. The API ZYM system yielded a distinct and consistent enzyme profile for all test strains, whereas the sensitivities of the other systems in identifying C. difficile ranged from 78 to 96% (AN-Ident, 77.9%; RapID-ANA, 88.6%; Minitek Anaerobe II, 90.9%; and API 20A, 95.5%). The API ZYM ...

  10. Population Genetics of Nosema apis and Nosema ceranae: One Host (Apis mellifera) and Two Different Histories

    Science.gov (United States)

    Maside, Xulio; Gómez-Moracho, Tamara; Jara, Laura; Martín-Hernández, Raquel; De la Rúa, Pilar; Higes, Mariano; Bartolomé, Carolina

    2015-01-01

    Two microsporidians are known to infect honey bees: Nosema apis and Nosema ceranae. Whereas population genetics data for the latter have been released in the last few years, such information is still missing for N. apis. Here we analyze the patterns of nucleotide polymorphism at three single-copy loci (PTP2, PTP3 and RPB1) in a collection of Apis mellifera isolates from all over the world, naturally infected either with N. apis (N = 22) or N. ceranae (N = 23), to provide new insights into the genetic diversity, demography and evolution of N. apis, as well as to compare them with evidence from N. ceranae. Neutral variation in N. apis and N. ceranae is of the order of 1%. This amount of diversity suggests that there is no substantial differentiation between the genetic content of the two nuclei present in these parasites, and evidence for genetic recombination provides a putative mechanism for the flow of genetic information between chromosomes. The analysis of the frequency spectrum of neutral variants reveals a significant surplus of low frequency variants, particularly in N. ceranae, and suggests that the populations of the two pathogens are not in mutation-drift equilibrium and that they have experienced a population expansion. Most of the variation in both species occurs within honey bee colonies (between 62%-90% of the total genetic variance), although in N. apis there is evidence for differentiation between parasites isolated from distinct A. mellifera lineages (20%-34% of the total variance), specifically between those collected from lineages A and C (or M). This scenario is consistent with a long-term host-parasite relationship and contrasts with the lack of differentiation observed among host-lineages in N. ceranae (< 4% of the variance), which suggests that the spread of this emergent pathogen throughout the A. mellifera worldwide population is a recent event. PMID:26720131

  11. Population Genetics of Nosema apis and Nosema ceranae: One Host (Apis mellifera and Two Different Histories.

    Directory of Open Access Journals (Sweden)

    Xulio Maside

    Full Text Available Two microsporidians are known to infect honey bees: Nosema apis and Nosema ceranae. Whereas population genetics data for the latter have been released in the last few years, such information is still missing for N. apis. Here we analyze the patterns of nucleotide polymorphism at three single-copy loci (PTP2, PTP3 and RPB1 in a collection of Apis mellifera isolates from all over the world, naturally infected either with N. apis (N = 22 or N. ceranae (N = 23, to provide new insights into the genetic diversity, demography and evolution of N. apis, as well as to compare them with evidence from N. ceranae. Neutral variation in N. apis and N. ceranae is of the order of 1%. This amount of diversity suggests that there is no substantial differentiation between the genetic content of the two nuclei present in these parasites, and evidence for genetic recombination provides a putative mechanism for the flow of genetic information between chromosomes. The analysis of the frequency spectrum of neutral variants reveals a significant surplus of low frequency variants, particularly in N. ceranae, and suggests that the populations of the two pathogens are not in mutation-drift equilibrium and that they have experienced a population expansion. Most of the variation in both species occurs within honey bee colonies (between 62%-90% of the total genetic variance, although in N. apis there is evidence for differentiation between parasites isolated from distinct A. mellifera lineages (20%-34% of the total variance, specifically between those collected from lineages A and C (or M. This scenario is consistent with a long-term host-parasite relationship and contrasts with the lack of differentiation observed among host-lineages in N. ceranae (< 4% of the variance, which suggests that the spread of this emergent pathogen throughout the A. mellifera worldwide population is a recent event.

  12. Large scale validation of the M5L lung CAD on heterogeneous CT datasets

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Torres, E., E-mail: Ernesto.Lopez.Torres@cern.ch, E-mail: cerello@to.infn.it [CEADEN, Havana 11300, Cuba and INFN, Sezione di Torino, Torino 10125 (Italy); Fiorina, E.; Pennazio, F.; Peroni, C. [Department of Physics, University of Torino, Torino 10125, Italy and INFN, Sezione di Torino, Torino 10125 (Italy); Saletta, M.; Cerello, P., E-mail: Ernesto.Lopez.Torres@cern.ch, E-mail: cerello@to.infn.it [INFN, Sezione di Torino, Torino 10125 (Italy); Camarlinghi, N.; Fantacci, M. E. [Department of Physics, University of Pisa, Pisa 56127, Italy and INFN, Sezione di Pisa, Pisa 56127 (Italy)

    2015-04-15

    Purpose: M5L, a fully automated computer-aided detection (CAD) system for the detection and segmentation of lung nodules in thoracic computed tomography (CT), is presented and validated on several image datasets. Methods: M5L is the combination of two independent subsystems, based on the Channeler Ant Model as a segmentation tool [lung channeler ant model (lungCAM)] and on the voxel-based neural approach. The lungCAM was upgraded with a scan equalization module and a new procedure to recover the nodules connected to other lung structures; its classification module, which makes use of a feed-forward neural network, is based of a small number of features (13), so as to minimize the risk of lacking generalization, which could be possible given the large difference between the size of the training and testing datasets, which contain 94 and 1019 CTs, respectively. The lungCAM (standalone) and M5L (combined) performance was extensively tested on 1043 CT scans from three independent datasets, including a detailed analysis of the full Lung Image Database Consortium/Image Database Resource Initiative database, which is not yet found in literature. Results: The lungCAM and M5L performance is consistent across the databases, with a sensitivity of about 70% and 80%, respectively, at eight false positive findings per scan, despite the variable annotation criteria and acquisition and reconstruction conditions. A reduced sensitivity is found for subtle nodules and ground glass opacities (GGO) structures. A comparison with other CAD systems is also presented. Conclusions: The M5L performance on a large and heterogeneous dataset is stable and satisfactory, although the development of a dedicated module for GGOs detection could further improve it, as well as an iterative optimization of the training procedure. The main aim of the present study was accomplished: M5L results do not deteriorate when increasing the dataset size, making it a candidate for supporting radiologists on large

  13. Taponamiento cardíaco por hipotiroidismo: descripción de 2 casos

    Directory of Open Access Journals (Sweden)

    José Rafael Rojas-Solano

    2005-07-01

    Full Text Available Rara vez el derrame pericárdico en el hipotiroidismo evoluciona al taponamiento cardíaco, complicación que es mortal si no se diagnostica y trata a tiempo. En este artículo describimos dos singulares casos y discutimos aspectos importantes de la fisiopatología, diagnóstico y manejo de esta enfermedad.Pericardial effusion in hypothyroidism seldom evolves to cardiac tamponade, a fatal complication if diagnosis and treatment are delayed. In this article, we describe 2 singular cases and discuss important facts about the pathophysiology, diagnosis and management of this disease.

  14. Transplante cardíaco em amiloidose primária Heart transplantation in primary amyloidosis

    Directory of Open Access Journals (Sweden)

    José Francisco Baumgratz

    2009-09-01

    Full Text Available A amiloidose cardíaca é doença altamente limitante da sobrevida, por morte súbita na maioria dos pacientes. Pela agressão contra outros órgãos, particularmente rins e sistema nervoso central, o transplante cardíaco tem sido opção questionável, face à escassez de órgãos. O objetivo é relatar a evolução, com sobrevivência de 7 anos, da paciente após transplante cardíaco por amiloidose, em boas condições. Um ano após o transplante cardíaco, houve indicação de transplante renal, também pela agressão da doença. Esta paciente contrasta com outros três pacientes de nosso serviço que foram a óbito, ainda na fase de avaliação. Apesar de sua natureza multisistêmica, a amiloidose cardíaca pode, em pacientes selecionados, justificar o transplante cardíaco, pela gravidade do seu potencial evolutivo após o início dos sintomasCardiac amyloidosis is a disease with a gloom life expectance after the beginning of the symptomatic phase, usually with sudden death as the final event. The aggression to other organs, although, can make heart transplantation a disputable form of treatment taking into consideration the shortage of donor organs. The aim is to report the evolution with a survival of seven years after heart transplantation and in very fair condition of a patient with amyloidosis. One year after the heart transplantation, there was indication of renal transplantation also from the aggression from the disease. This patient compares' favorable with three other patients also from our service, who died early after de diagnosis. Even considering the multi systemic nature of amyloidosis, we can accept that in peculiar patients justified the heart transplantation, taking in the consideration the very bad prognosis of the disease

  15. Effects of Nosema apis, N. ceranae, and coinfections on honey bee (Apis mellifera) learning and memory.

    Science.gov (United States)

    Charbonneau, Lise R; Hillier, Neil Kirk; Rogers, Richard E L; Williams, Geoffrey R; Shutler, Dave

    2016-01-01

    Western honey bees (Apis mellifera) face an increasing number of challenges that in recent years have led to significant economic effects on apiculture, with attendant consequences for agriculture. Nosemosis is a fungal infection of honey bees caused by either Nosema apis or N. ceranae. The putative greater virulence of N. ceranae has spurred interest in understanding how it differs from N. apis. Little is known of effects of N. apis or N. ceranae on honey bee learning and memory. Following a Pavlovian model that relies on the proboscis extension reflex, we compared acquisition learning and long-term memory recall of uninfected (control) honey bees versus those inoculated with N. apis, N. ceranae, or both. We also tested whether spore intensity was associated with variation in learning and memory. Neither learning nor memory differed among treatments. There was no evidence of a relationship between spore intensity and learning, and only limited evidence of a negative effect on memory; this occurred only in the co-inoculation treatment. Our results suggest that if Nosema spp. are contributing to unusually high colony losses in recent years, the mechanism by which they may affect honey bees is probably not related to effects on learning or memory, at least as assessed by the proboscis extension reflex. PMID:26961062

  16. Domainwise Web Page Optimization Based On Clustered Query Sessions Using Hybrid Of Trust And ACO For Effective Information Retrieval

    Directory of Open Access Journals (Sweden)

    Dr. Suruchi Chawla

    2015-08-01

    Full Text Available Abstract In this paper hybrid of Ant Colony OptimizationACO and trust has been used for domainwise web page optimization in clustered query sessions for effective Information retrieval. The trust of the web page identifies its degree of relevance in satisfying specific information need of the user. The trusted web pages when optimized using pheromone updates in ACO will identify the trusted colonies of web pages which will be relevant to users information need in a given domain. Hence in this paper the hybrid of Trust and ACO has been used on clustered query sessions for identifying more and more relevant number of documents in a given domain in order to better satisfy the information need of the user. Experiment was conducted on the data set of web query sessions to test the effectiveness of the proposed approach in selected three domains Academics Entertainment and Sports and the results confirm the improvement in the precision of search results.

  17. A novel phylogeny and morphological reconstruction of the PIN genes and first phylogeny of the ACC-oxidases (ACOs

    Directory of Open Access Journals (Sweden)

    Ronald Matthew Clouse

    2014-06-01

    Full Text Available The PIN and ACO gene families present interesting questions about the evolution of plant physiology, including testing hypotheses about the ecological drivers of their diversification and whether unrelated genes have been recruited for similar functions. The PIN-formed proteins contribute to the polar transport of auxin, a hormone which regulates plant growth and development. PIN loci are categorized into groups according to their protein length and structure, as well as subcellular localization. An interesting question with PIN genes is the nature of the ancestral form and location. ACOs are members of a superfamily of oxygenases and oxidases that catalyze the last step of ethylene synthesis, which regulates many aspects of the plant life cycle. We used publicly available PIN and ACO sequences to conduct phylogenetic analyses. Third codon positions of these genes in monocots have a high GC content, which could be historical but is more likely due to a mutational bias. Thus we developed methods to extract phylogenetic information from nucleotide sequences while avoiding this convergent feature. One method consisted in using only A-T transformations, and another used only the first and second codon positions for serine, which can only take A or T and G or C, respectively. We also conducted tree-searches for both gene families using unaligned amino acid sequences and dynamic homology. PIN genes appear to have diversified earlier than ACOs, with monocot and dicot copies more mixed in the phylogeny. However, gymnosperm PINs appear to be derived and not closely related to those from primitive plants. We find strong support for a long PIN gene ancestor with short forms subsequently evolving one or more times. ACO genes appear to have diversified mostly since the dicot-monocot split, as most genes cluster into a small number of monocot and dicot clades when the tree is rooted by genes from mosses. Gymnosperm ACOs were recovered as closely related and

  18. A novel phylogeny and morphological reconstruction of the PIN genes and first phylogeny of the ACC-oxidases (ACOs).

    Science.gov (United States)

    Clouse, Ronald M; Carraro, Nicola

    2014-01-01

    The PIN and ACO gene families present interesting questions about the evolution of plant physiology, including testing hypotheses about the ecological drivers of their diversification and whether unrelated genes have been recruited for similar functions. The PIN-formed proteins contribute to the polar transport of auxin, a hormone which regulates plant growth and development. PIN loci are categorized into groups according to their protein length and structure, as well as subcellular localization. An interesting question with PIN genes is the nature of the ancestral form and location. ACOs are members of a superfamily of oxygenases and oxidases that catalyze the last step of ethylene synthesis, which regulates many aspects of the plant life cycle. We used publicly available PIN and ACO sequences to conduct phylogenetic analyses. Third codon positions of these genes in monocots have a high GC content, which could be historical but is more likely due to a mutational bias. Thus, we developed methods to extract phylogenetic information from nucleotide sequences while avoiding this convergent feature. One method consisted in using only A-T transformations, and another used only the first and second codon positions for serine, which can only take A or T and G or C, respectively. We also conducted tree-searches for both gene families using unaligned amino acid sequences and dynamic homology. PIN genes appear to have diversified earlier than ACOs, with monocot and dicot copies more mixed in the phylogeny. However, gymnosperm PINs appear to be derived and not closely related to those from primitive plants. We find strong support for a long PIN gene ancestor with short forms subsequently evolving one or more times. ACO genes appear to have diversified mostly since the dicot-monocot split, as most genes cluster into a small number of monocot and dicot clades when the tree is rooted by genes from mosses. Gymnosperm ACOs were recovered as closely related and derived.

  19. A novel phylogeny and morphological reconstruction of the PIN genes and first phylogeny of the ACC-oxidases (ACOs).

    Science.gov (United States)

    Clouse, Ronald M; Carraro, Nicola

    2014-01-01

    The PIN and ACO gene families present interesting questions about the evolution of plant physiology, including testing hypotheses about the ecological drivers of their diversification and whether unrelated genes have been recruited for similar functions. The PIN-formed proteins contribute to the polar transport of auxin, a hormone which regulates plant growth and development. PIN loci are categorized into groups according to their protein length and structure, as well as subcellular localization. An interesting question with PIN genes is the nature of the ancestral form and location. ACOs are members of a superfamily of oxygenases and oxidases that catalyze the last step of ethylene synthesis, which regulates many aspects of the plant life cycle. We used publicly available PIN and ACO sequences to conduct phylogenetic analyses. Third codon positions of these genes in monocots have a high GC content, which could be historical but is more likely due to a mutational bias. Thus, we developed methods to extract phylogenetic information from nucleotide sequences while avoiding this convergent feature. One method consisted in using only A-T transformations, and another used only the first and second codon positions for serine, which can only take A or T and G or C, respectively. We also conducted tree-searches for both gene families using unaligned amino acid sequences and dynamic homology. PIN genes appear to have diversified earlier than ACOs, with monocot and dicot copies more mixed in the phylogeny. However, gymnosperm PINs appear to be derived and not closely related to those from primitive plants. We find strong support for a long PIN gene ancestor with short forms subsequently evolving one or more times. ACO genes appear to have diversified mostly since the dicot-monocot split, as most genes cluster into a small number of monocot and dicot clades when the tree is rooted by genes from mosses. Gymnosperm ACOs were recovered as closely related and derived. PMID

  20. Studies on Pumice Lightweight Aggregate Concrete with Quarry Dust Using Mathematical Modeling Aid of ACO Techniques

    Directory of Open Access Journals (Sweden)

    J. Rex

    2016-01-01

    Full Text Available The lightweight aggregate is an aggregate that weighs less than the usual rock aggregate and the quarry dust is a rock particle used in the concrete for the experimentation. The significant intention of the proposed technique is to frame a mathematical modeling with the aid of the optimization techniques. The mathematical modeling is done by minimizing the cost and time consumed in the case of extension of the real time experiment. The proposed mathematical modeling is utilized to predict four output parameters such as compressive strength (Mpa, split tensile strength (Mpa, flexural strength (Mpa, and deflection (in mm. Here, the modeling is carried out with three different optimization techniques like genetic algorithm (GA, particle swarm optimization (PSO, and ant colony optimization (ACO with 80% of data from experiment utilized for the training and the remaining 20% for the validation. Finally, while testing, the error value is minimized and the performance obtained in the ACO for the parameters such as compressive strength, split tensile strength, flexural strength, and deflection is 91%, 98%, 87%, and 94% of predicted values, respectively, in the mathematical modeling.

  1. Marcadores cardíacos na medicina veterinária Cardiac markers in veterinary medicine

    Directory of Open Access Journals (Sweden)

    Letícia Andreza Yonezawa

    2010-02-01

    Full Text Available Os marcadores cardíacos são utilizados com o intuito de auxiliar no diagnóstico clínico de animais com doença cardíaca com maior acurácia e em menor tempo possível, possibilitando o estabelecimento do prognóstico e a terapia precocemente. Entretanto, em medicina veterinária, no Brasil, sua aplicabilidade ainda é, em geral, restrita a pesquisas. Esta revisão tem como objetivo abordar os principais marcadores cardíacos para que futuramente estes possam se tornar índices essenciais na avaliação cardíaca.Cardiac markers have been used in order to assist clinical diagnosis of animals with heart disease, more accurately, enabling the establishment of earlier prognosis and therapy. However, in Brazilian veterinary medicine, these markers are generally still restricted to researches. This review aims to approach the major cardiac markers, which further may become essential indexes in heart assessment.

  2. Optimization of Vibration Reduction Ability of Ladder Tracks by FEM Coupled with ACO

    Directory of Open Access Journals (Sweden)

    Hao Jin

    2015-01-01

    Full Text Available Ladder track, which has drawn increased attention in scientific communities, is an effective method for reducing vibrations from underground railways. In order to optimize the vibration reduction ability of ladder track, a new method, that is, the finite element method (FEM coupled with ant colony optimization (ACO, has been proposed in this paper. We describe how to build the FEM model verified by the vibration tests in the Track Vibration Abatement and Control Laboratory and how to couple the FEM with ACO. The density and elasticity modulus of the sleeper pad are optimized using this method. After optimization, the vibration acceleration level of the supporting platform in the 1–200 Hz range was reduced from 102.8 dB to 94.4 dB. The optimized density of the sleeper pad is 620 kg/m3, and the optimized elasticity modulus of the sleeper pad is 6.25 × 106 N/m2.

  3. Application of GA, PSO, and ACO Algorithms to Path Planning of Autonomous Underwater Vehicles

    Institute of Scientific and Technical Information of China (English)

    Mohammad Pourmahmood Aghababa; Mohammad Hossein Amrollahi; Mehdi Borjkhani

    2012-01-01

    In this paper,an underwater vehicle was modeled with six dimensional nonlinear equations of motion,controlled by DC motors in all degrees of freedom.Near-optimal trajectories in an energetic environment for underwater vehicles were computed using a numerical solution of a nonlinear optimal control problem (NOCP).An energy performance index as a cost function,which should be minimized,was defined.The resulting problem was a two-point boundary value problem (TPBVP).A genetic algorithm (GA),particle swarm optimization (PSO),and ant colony optimization (ACO) algorithms were applied to solve the resulting TPBVP.Applying an Euler-Lagrange equation to the NOCE a conjugate gradient penalty method was also adopted to solve the TPBVP.The problem of energetic environments,involving some energy sources,was discussed.Some near-optimal paths were found using a GA,PSO,and ACO algorithms.Finally,the problem of collision avoidance in an energetic environment was also taken into account.

  4. Sarcoidosis cardíaca: trasplante cardíaco y recidiva de la enfermedad

    Directory of Open Access Journals (Sweden)

    César A. Belziti

    2010-01-01

    Full Text Available RESUMENLa sarcoidosis cardíaca es una enfermedad granulomatosa multisistémica de causa desconocida.El compromiso aislado del corazón es poco frecuente y el pronóstico se correlacionacon el grado de afectación de este órgano. El tratamiento inmunosupresor y el trasplantecardíaco han demostrado que prolongan la sobrevida; no obstante, existen comunicacionesde recidiva de la enfermedad en el órgano implantado. En esta presentación se describe uncaso de recidiva de sarcoidosis cardíaca en un paciente con miocardiopatía dilatada coninsuficiencia cardíaca avanzada, sometido a un trasplante cardíaco y en quien el diagnósticode sarcoidosis cardíaca se estableció por el estudio anatomopatológico del corazón explantado.La evolución clínica fue favorable a pesar de la recidiva de la sarcoidosis en el órgano implantado.REV ARGENT CARDIOL 2010;78:358-360.

  5. Open Mobile API: Accessing the UICC on Android Devices

    OpenAIRE

    Roland, Michael; Hölzl, Michael

    2016-01-01

    This report gives an overview of secure element integration into Android devices. It focuses on the Open Mobile API as an open interface to access secure elements from Android applications. The overall architecture of the Open Mobile API is described and current Android devices are analyzed with regard to the availability of this API. Moreover, this report summarizes our efforts of reverse engineering the stock ROM of a Samsung Galaxy S3 in order to analyze the integration of the Open Mobile ...

  6. Privacy Issues of the W3C Geolocation API

    CERN Document Server

    Doty, Nick; Wilde, Erik

    2010-01-01

    The W3C's Geolocation API may rapidly standardize the transmission of location information on the Web, but, in dealing with such sensitive information, it also raises serious privacy concerns. We analyze the manner and extent to which the current W3C Geolocation API provides mechanisms to support privacy. We propose a privacy framework for the consideration of location information and use it to evaluate the W3C Geolocation API, both the specification and its use in the wild, and recommend some modifications to the API as a result of our analysis.

  7. What Should Developers Be Aware Of? An Empirical Study on the Directives of API Documentation

    CERN Document Server

    Monperrus, Martin; Tekes, Elif; Mezini, Mira

    2012-01-01

    Application Programming Interfaces (API) are exposed to developers in order to reuse software libraries. API directives are natural-language statements in API documentation that make developers aware of constraints and guidelines related to the usage of an API. This paper presents the design and the results of an empirical study on the directives of API documentation of object-oriented libraries. Its main contribution is to propose and extensively discuss a taxonomy of 23 kinds of API directives.

  8. Effect of Celluclast 1.5L on the Physicochemical Characterization of Gold Kiwifruit Pectin

    Directory of Open Access Journals (Sweden)

    John A. Mawson

    2011-09-01

    Full Text Available The effects of Celluclast 1.5L concentration on the physicochemical characterization of gold kiwifruit pectin was evaluated. Varying the enzyme concentration affected the pectin yield and pectin physicochemical properties. The viscosity of extracted pectin was largely dependent on the enzyme concentration. Celluclast 1.5L with medium concentration exhibited the highest viscosity. Varying the enzyme concentration also influenced the molecular weight distribution. High molecular weight (Mw pectin (1.65 × 106 g/mol was obtained when the medium concentration was used. Overall, the study clearly reflects the importance of taking into consideration the amount of cellulytic enzyme added in order to determine the final quality of pectin.

  9. NHETS - Estudo de Necrópsias de Pacientes Submetidos a Transplante Cardíaco

    Directory of Open Access Journals (Sweden)

    Thiago Ninck Valette

    2014-06-01

    Full Text Available Fundamento: Discordâncias entre diagnóstico pre e post-mortem são relatadas na literatura, podendo variar de 4,1 a 49,8% dentre os casos encaminhados para exame necroscópico, com importante repercussão no tratamento dos pacientes. Objetivo: Analisar pacientes com óbito após o transplante cardíaco e confrontar os diagnósticos pre e post-mortem. Métodos: Por meio da revisão de prontuários, foram analisados dados clínicos, presença de comorbidades, esquema de imunossupressão, exames laboratoriais, causa clínica do óbito e causa do óbito à necrópsia. Foram confrontadas, então, a causa clínica e a causa necroscópica do óbito de cada paciente. Resultados: Foram analisados 48 óbitos submetidos à necrópsia no período de 2000 a 2010; 29 (60,4% tiveram diagnósticos clínico e necroscópico concordantes, 16 (33,3% tiveram diagnósticos discordantes e três (6,3% tiveram diagnóstico não esclarecido. Entre os discordantes, 15 (31,3% apresentaram possível impacto na sobrevida e um (2,1% não apresentou impacto na sobrevida. O principal diagnóstico clínico feito equivocadamente foi o de infecção, com cinco casos (26,7% dos discordantes, seguido por rejeição hiperaguda, com quatro casos (20% dos discordantes, e tromboembolismo pulmonar, com três casos (13,3% dos discordantes. Conclusão: Discordâncias entre o diagnóstico clínico e achados da necrópsia são comumente encontradas no transplante cardíaco. Novas estratégias no aperfeiçoamento do diagnóstico clínico devem ser introduzidas, considerando-se os resultados da necrópsia para melhoria do tratamento da insuficiência cardíaca por meio do transplante cardíaco.

  10. STABILITY TESTING OF ACTIVE PHARMACEUTICAL INGREDIENT [API

    Directory of Open Access Journals (Sweden)

    Agarwal Vipul

    2012-04-01

    Full Text Available Stability plays an important role in drug development process. It explains several factors that affect the quality of a drug substance or drug products varies with time under the influence of environmental factors such as temperature, humidity and light. Stability studies play a vital role to decide the re-test period and shelf life for the drug substance and recommended storage conditions of API. ICH and EMEA guidelines define stability data package for new drug substance or drug product that is sufficient for a registration application within the three regions of the EC, Japan and United States.

  11. Adaptive runtime for a multiprocessing API

    Energy Technology Data Exchange (ETDEWEB)

    Antao, Samuel F.; Bertolli, Carlo; Eichenberger, Alexandre E.; O' Brien, John K.

    2016-10-11

    A computer-implemented method includes selecting a runtime for executing a program. The runtime includes a first combination of feature implementations, where each feature implementation implements a feature of an application programming interface (API). Execution of the program is monitored, and the execution uses the runtime. Monitor data is generated based on the monitoring. A second combination of feature implementations are selected, by a computer processor, where the selection is based at least in part on the monitor data. The runtime is modified by activating the second combination of feature implementations to replace the first combination of feature implementations.

  12. API and CPTDC Jointly Promote Chinese Enterprises to Go Abroad

    Institute of Scientific and Technical Information of China (English)

    Li Chunhui

    2005-01-01

    @@ In order to push the certification forward and help more Chinese enterprises to go abroad, API (American Petroleum Institute) and CPTDC (China Petroleum Technology & Development Corporation) jointly held a meeting between March 4 and 8, 2004, to promote API certification of Chinese enterprises.

  13. Interfacing RASCAL with Java APIs. Automated mapping with Apache POI

    NARCIS (Netherlands)

    Marmanidis, G.

    2013-01-01

    Interfacing RASCAL with Java APIs and reusing existing implementations is a required functionality in order to reduce effort and time in contrast with implementing a new one from scratch. In this study we are trying to interface RASCAL with Apache POI, a Java implemented API in order to import and a

  14. Experience API: Flexible, Decentralized and Activity-Centric Data Collection

    Science.gov (United States)

    Kevan, Jonathan M.; Ryan, Paul R.

    2016-01-01

    This emerging technology report describes the Experience API (xAPI), a new e-learning specification designed to support the learning community in standardizing and collecting both formal and informal distributed learning activities. Informed by Activity Theory, a framework aligned with constructivism, data is collected in the form of activity…

  15. Transplante cardíaco humano: experiência inicial Human cardiac transplant: initial experience

    OpenAIRE

    Noedir A. G Stolf; Edimar Bocchi; Pedro C. P Lemos; Fábio Biscegli Jatene; Pablo M. A. Pomerantzeff; Lourdes Higushi; Jorge Kalil; Alfredo I. FIORELLI; José Otávio C Auler Júnior; Giovanni Bellotti; Lélio A Silva; Fúlvio Pileggi; Adib D Jatene

    1986-01-01

    No Instituto do Coração, de março de 1985 a fevereiro de 1986,11 pacientes foram submetidos a transplante cardíaco ortotópico. Eram todos do sexo masculino, com idade variando de 39 a 54 anos; 6 com cardiopatia isquémica, 4 com cardiomiopatia dilatada e um com cardiomiopatia chagásica. Foi realizado estudo hemodinâmico através de catéter de Swan-Ganz, no pré-operatório, no pós-operatório, após estabilização na unidade de recuperação, e trinta ou mais dias após o transplante. Os dados mostram ...

  16. Experimental evaluation of a R134a/CO2 cascade refrigeration plant

    International Nuclear Information System (INIS)

    We present the experimental evaluation of a R134a/CO2 cascade refrigeration plant designed for low evaporation temperature in commercial refrigeration applications. The test bench incorporates two single-stage vapour compression cycles driven by semi hermetic compressors coupled thermally through two brazed plate cascade heat exchangers working in parallel and controlled by electronic expansion valves. The experimental evaluation (45 steady-states) covers evaporating temperatures from −40 to −30 °C and condensing from 30 to 50 °C. In each steady-state, we conducted a sweep of the condensing temperature of the low temperature cycle with speed variation of the high temperature compressor. Here, the energy performance of the plant is analysed, focussing on the compressors' performance, temperature difference in the cascade heat exchanger, cooling capacity, COP and compressors discharge temperatures. - Highlights: • The experimental evaluation of a R134a/CO2 cascade refrigeration plant is presented. • Temperature difference in cascade heat exchanger varied from 3.3 to 5.3 °C. • Variation of intermediate level produced maximum COP variations of 6%. • Cooling capacity ranged from 4.5 kW (−40 and 40 °C) to 7.5 kW (−30 and 30 °C). • COP ranged from 1.05 (−40 and 40 °C) to 1.65 (−30 and 30 °C)

  17. API E MIELE NEL MEDITERRANEO ANTICO

    Directory of Open Access Journals (Sweden)

    Matteo Bormetti

    2014-09-01

    Full Text Available L’importanza del miele come sostanza culturalmente ed economicamente rilevante nel mondo antico non è stata ancora del tutto indagata. Il miele e le api sono nondimeno presenze assidue e trasversali ai generi e alle tipologie di fonti antiche greche e romane, ed è pertanto da esse che una ricerca sull’argomento deve partire. I manufatti, le tecniche e i concetti descritti dagli antichi devono però essere relazionati con cautela al materiale archeologico rinvenuto, per fare ciò pare indispensabile un approccio che tenga conto delle nozioni biologiche, etologiche e zootecniche di base. Attraverso quest’ottica sono state ricapitolate le evidenze materiali provenienti dal bacino del Mediterraneo e concernenti gli strumenti e le strutture relative all’apicoltura, dalle arnie agli apiari, peril lungo arco cronologico che va dall’età del bronzo alla tarda antichità. Ciò è possibile per la tematica apicola grazie alla conservatività delle tecniche, strettamente legate ai severi dettami della natura fino alla rivoluzione ottocentesca delle arnie razionali a telai mobili del reverendo Langstroth. Sono inoltre analizzati gli utilizzi più frequenti del miele per come descritti dalle fonti letterarie nonché le implicazioni di api e miele nella ritualità e nel simbolismo della morte, del genere e della regalità, sebbene i risultati siano scarsi data la povertà dei riscontri archeologici e la limitata attenzione di cui questo argomento ha fin ora goduto.

  18. Hymenoptera venom review focusing on Apis mellifera

    Directory of Open Access Journals (Sweden)

    P. R. de Lima

    2003-01-01

    Full Text Available Hymenoptera venoms are complex mixtures containing simple organic molecules, proteins, peptides, and other bioactive elements. Several of these components have been isolated and characterized, and their primary structures determined by biochemical techniques. These compounds are responsible for many toxic or allergic reactions in different organisms, such as local pain, inflammation, itching, irritation, and moderate or severe allergic reactions. The most extensively characterized Hymenoptera venoms are bee venoms, mainly from the Apis genus and also from social wasps and ant species. However, there is little information about other Hymenoptera groups. The Apis venom presents high molecular weight molecules - enzymes with a molecular weight higher than 10.0 kDa - and peptides. The best studied enzymes are phospholipase A2, responsible for cleaving the membrane phospholipids, hyaluronidase, which degrades the matrix component hyaluronic acid into non-viscous segments and acid phosphatase acting on organic phosphates. The main peptide compounds of bee venom are lytic peptide melittin, apamin (neurotoxic, and mastocyte degranulating peptide (MCD.

  19. Investigating an API for resilient exascale computing.

    Energy Technology Data Exchange (ETDEWEB)

    Stearley, Jon R.; Tomkins, James; VanDyke, John P.; Ferreira, Kurt Brian; Laros, James H.,; Bridges, Patrick

    2013-05-01

    Increased HPC capability comes with increased complexity, part counts, and fault occurrences. In- creasing the resilience of systems and applications to faults is a critical requirement facing the viability of exascale systems, as the overhead of traditional checkpoint/restart is projected to outweigh its bene ts due to fault rates outpacing I/O bandwidths. As faults occur and propagate throughout hardware and software layers, pervasive noti cation and handling mechanisms are necessary. This report describes an initial investigation of fault types and programming interfaces to mitigate them. Proof-of-concept APIs are presented for the frequent and important cases of memory errors and node failures, and a strategy proposed for lesystem failures. These involve changes to the operating system, runtime, I/O library, and application layers. While a single API for fault handling among hardware and OS and application system-wide remains elusive, the e ort increased our understanding of both the mountainous challenges and the promising trailheads. 3

  20. Coming 5th Edition of the API Standard 618: major changes compared to the API 618, 4th edition

    NARCIS (Netherlands)

    Pyle, A.; Eijk, A.; Elferink, H.

    2003-01-01

    This paper will present the highlights of changes that will be found in the 5th Edition of API 618, which is expected to be published in late 2003 or early 2004. Approximately every 5 years the API Standards are revised in such a way that the latest field experiences and proven designs are included

  1. NORMATIVE VALUES OF EQ-5D-5L FOR DIABETES PATIENTS FROM SPAIN.

    Science.gov (United States)

    Collado Mateo, Daniel; García Gordillo, Miguel A; Olivares, Pedro R; Adsuar, José C

    2015-10-01

    Introducción: la diabetes es una enfermedad metabólica que puede conllevar una reducción de la calidad de vida relacionada con la salud. El EQ-5D es un cuestionario genérico de calidad de vida relacionada con la salud basado en preferencias sociales. Este cuestionario ha sido muy utilizado en pacientes con diabetes. Objetivo: el objetivo del presente artículo es informar sobre los valores normativos del cuestionario EQ-5D-5L en personas españolas con diabetes. Métodos: se utilizaron datos de la Encuesta Española de Salud (2011/2012). Un total de 1.857 personas con diabetes participaron en la encuesta. La puntuación del EQ-5D-5L se ha reflejado en función del sexo, región (incluyendo las 17 comunidades autónomas y las 2 ciudades autónomas de España), y 8 grupos de edad. Resultados: la media del índice de utilidad para toda la muestra fue de 0,742. Esta fue mejor para hombres (0,826) que para mujeres (0,673). Resultados similares se observaron en la Escala Visual Analógica. El efecto techo fue mucho mayor en hombres (44,83%) que en mujeres (24,41%). Conclusiones: el presente estudio recoge datos normativos representativos del EQ-5D-5L en España de personas con diabetes.

  2. Comparing responsiveness of the EQ-5D-5L, EQ-5D-3L and EQ VAS in stroke patients

    NARCIS (Netherlands)

    D. Golicki (Dominik); M. Niewada (Maciej); A. Karlińska (Anna); J. Buczek (Julia); A. Kobayashi (Adam); M.F. Janssen (Mathieu); A.S. Pickard (Simon)

    2015-01-01

    textabstractAims: To date, evidence to support the construct validity of the EQ-5D-5L has primarily focused on cross-sectional data. The aims of this study were to examine the responsiveness of EQ-5D-5L in patients with stroke and to compare it with responsiveness of EQ-5D-3L and visual analogue sca

  3. The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses.

    Science.gov (United States)

    Sanjurjo, Lucía; Amézaga, Núria; Aran, Gemma; Naranjo-Gómez, Mar; Arias, Lilibeth; Armengol, Carolina; Borràs, Francesc E; Sarrias, Maria-Rosa

    2015-01-01

    CD5L (CD5 molecule-like) is a secreted glycoprotein that participates in host response to bacterial infection. CD5L influences the monocyte inflammatory response to the bacterial surface molecules lipopolysaccharide (LPS) and lipoteichoic acid (LTA) by inhibiting TNF secretion. Here we studied the intracellular events that lead to macrophage TNF inhibition by human CD5L. To accomplish this goal, we performed functional analyses with human monocytic THP1 macrophages, as well as with peripheral blood monocytes. Inhibition of phosphatidylinositol 3-kinase (PtdIns3K) reversed the inhibitory effect of CD5L on TNF secretion. Among the various PtdIns3K isoforms, our results indicated that CD5L activates PtdIns3K (whose catalytic subunit is termed PIK3C3), a key modulator involved in autophagy. Further analysis revealed a concomitant enhancement of autophagy markers such as cellular LC3-II content, increased LC3 puncta, as well as LC3-LysoTracker Red colocalization. Moreover, electron microscopy showed an increased presence of cytosolic autophagosomes in THP1 macrophages overexpressing CD5L. Besides preventing TNF secretion, CD5L also inhibited IL1B and enhanced IL10 secretion. This macrophage anti-inflammatory pattern of CD5L was reverted upon silencing of autophagy protein ATG7 by siRNA transfection. Additional siRNA experiments in THP1 macrophages indicated that the induction of autophagy mechanisms by CD5L was achieved through cell-surface scavenger receptor CD36, a multiligand receptor expressed in a wide variety of cell types. Our data represent the first evidence that CD36 is involved in autophagy and point to a significant contribution of the CD5L-CD36 axis to the induction of macrophage autophagy.

  4. The IRMIS object model and services API.

    Energy Technology Data Exchange (ETDEWEB)

    Saunders, C.; Dohan, D. A.; Arnold, N. D.; Accelerator Systems Division (APS)

    2005-01-01

    The relational model developed for the Integrated Relational Model of Installed Systems (IRMIS) toolkit has been successfully used to capture the Advanced Photon Source (APS) control system software (EPICS process variables and their definitions). The relational tables are populated by a crawler script that parses each Input/Output Controller (IOC) start-up file when an IOC reboot is detected. User interaction is provided by a Java Swing application that acts as a desktop for viewing the process variable information. Mapping between the display objects and the relational tables was carried out with the Hibernate Object Relational Modeling (ORM) framework. Work is well underway at the APS to extend the relational modeling to include control system hardware. For this work, due in part to the complex user interaction required, the primary application development environment has shifted from the relational database view to the object oriented (Java) perspective. With this approach, the business logic is executed in Java rather than in SQL stored procedures. This paper describes the object model used to represent control system software, hardware, and interconnects in IRMIS. We also describe the services API used to encapsulate the required behaviors for creating and maintaining the complex data. In addition to the core schema and object model, many important concepts in IRMIS are captured by the services API. IRMIS is an ambitious collaborative effort for defining and developing a relational database and associated applications to comprehensively document the large and complex EPICS-based control systems of today's accelerators. The documentation effort includes process variables, control system hardware, and interconnections. The approach could also be used to document all components of the accelerator, including mechanical, vacuum, power supplies, etc. One key aspect of IRMIS is that it is a documentation framework, not a design and development tool. We do not

  5. The IRMIS object model and services API

    International Nuclear Information System (INIS)

    The relational model developed for the Integrated Relational Model of Installed Systems (IRMIS) toolkit has been successfully used to capture the Advanced Photon Source (APS) control system software (EPICS process variables and their definitions). The relational tables are populated by a crawler script that parses each Input/Output Controller (IOC) start-up file when an IOC reboot is detected. User interaction is provided by a Java Swing application that acts as a desktop for viewing the process variable information. Mapping between the display objects and the relational tables was carried out with the Hibernate Object Relational Modeling (ORM) framework. Work is well underway at the APS to extend the relational modeling to include control system hardware. For this work, due in part to the complex user interaction required, the primary application development environment has shifted from the relational database view to the object oriented (Java) perspective. With this approach, the business logic is executed in Java rather than in SQL stored procedures. This paper describes the object model used to represent control system software, hardware, and interconnects in IRMIS. We also describe the services API used to encapsulate the required behaviors for creating and maintaining the complex data. In addition to the core schema and object model, many important concepts in IRMIS are captured by the services API. IRMIS is an ambitious collaborative effort for defining and developing a relational database and associated applications to comprehensively document the large and complex EPICS-based control systems of today's accelerators. The documentation effort includes process variables, control system hardware, and interconnections. The approach could also be used to document all components of the accelerator, including mechanical, vacuum, power supplies, etc. One key aspect of IRMIS is that it is a documentation framework, not a design and development tool. We do not

  6. The Marker Gene ACO of Fruits Preservation%果树果实保鲜力强弱标记基因ACO

    Institute of Scientific and Technical Information of China (English)

    张太奎; 纵丹; 朱芳明; 贺笑; 刘惠民; 张汉尧

    2015-01-01

    果树果实的成熟期与保鲜是影响其经济价值的重要因素,ACC氧化酶是植物乙烯合成途径中的重要酶,催化ACC合成乙烯,进而催化果实的成熟.研究ACC氧化酶基因(ACO)对标记和提高果实的保鲜力具有重要意义.本研究对中华猕猴桃(Actinidia chinensis)、美味猕猴桃(Actinidia deliciosa)、杏(Prunus armeniaca)、葡萄(Vitis vinifera)、苹果(Malus domestica)、西洋梨(Pyrus communis)、沙梨(Pyrus pyrifolia)、桃(Prunus persica)、梅(Prunus mume)、大蕉(Musa ABB)10种果树的ACO基因进行氨基酸序列、蛋白质理化性质及结构、系统发育等生物信息学进行分析,并对这10种果树进行聚类.结果表明:(1)苹果较梅更耐储藏,桃与杏保鲜能力相当,西洋梨和沙梨保鲜力相当,中华猕猴桃和美味猕猴桃保鲜力相当;(2) ACO基因可用于同科物种间保鲜能力的选择,这可能与ACO基因编码氨基酸序列18位点处变异、2OG-Fell Oxy基因家族的高度保守和ACO的多元作用机制有关;(3) ACO的作用机制为在游离核糖体上合成稳定的亲水性蛋白质后,不经蛋白转运,直接在细胞膜内表面氧化ACC合成乙烯,受基因型和外界刺激的多重影响.因此,果树ACO基因可用于属间物种间果实保鲜能力的选择,是一个重要的功能基因.

  7. Building Hypermedia APIs with HTML5 and Node

    CERN Document Server

    Amundsen, Mike

    2011-01-01

    With this concise book, you'll learn the art of building hypermedia APIs that don't simply run on the Web, but that actually exist in the Web. You'll start with the general principles and technologies behind this architectural approach, and then dive hands-on into three fully-functional API examples. Too many APIs rely on concepts rooted in desktop and local area network patterns that don't scale well-costly solutions that are difficult to maintain over time. This book shows system architects and web developers how to design and implement human- and machine-readable web services that remain

  8. Privacy Issues of the W3C Geolocation API

    OpenAIRE

    Doty, Nick; Mulligan, Deirdre K.; Wilde, Erik

    2010-01-01

    The W3C's Geolocation API may rapidly standardize the transmission of location information on the Web, but, in dealing with such sensitive information, it also raises serious privacy concerns. We analyze the manner and extent to which the current W3C Geolocation API provides mechanisms to support privacy. We propose a privacy framework for the consideration of location information and use it to evaluate the W3C Geolocation API, both the specification and its use in the wild, and recommend s...

  9. Taponamiento cardíaco secundario a carcinoma papilar esclerosante difuso de tiroides

    Directory of Open Access Journals (Sweden)

    Verónica Riva

    2011-12-01

    Full Text Available El carcinoma papilar, variante esclerosante difusa, corresponde al 2% de todos los carcinomas papilares de la tiroides. Se caracteriza por comprometer de manera difusa y bilateral a la glándula tiroides. Clínicamente se manifiesta con metástasis ganglionares y pulmonares, afectando predominantemente a mujeres jóvenes. Se describe un caso de taponamiento cardíaco como presentación inicial de un carcinoma papilar de tiroides variante esclerosante difusa. Una mujer de 32 años concurrió al servicio de emergencias médicas refiriendo epigastralgia y tos seca. Durante el examen físico se constató hipotensión arterial, taquicardia y ruidos cardíacos disminuidos. Se realizó un ecocardiograma, observándose derrame pericárdico. Por medio de una pericardiocentesis se obtuvo líquido pericárdico, cuyo análisis mostró células neoplásicas. Durante la evolución la paciente presentó recurrencia del derrame pericárdico por lo que se realizó una ventana pleuropericárdica, detectándose durante la cirugía una lesión nodular subpleural, la cual fue biopsiada e informada posteriormente como una metástasis de carcinoma papilar vinculable a origen tiroideo. Se realizó una tiroidectomía total con linfadenectomía cervical bilateral. El diagnóstico final fue carcinoma papilar, variante esclerosante difusa. Esta variante infiltra el tejido conectivo de los espacios interfoliculares, simulando una tiroiditis y se caracteriza por una permeación vascular temprana. En oposición a la variante clásica, la esclerosante difusa presenta mayor agresividad y mayor tasa de recurrencia. El carcinoma papilar de tiroides debe tenerse presente como diagnóstico diferencial en nuestro medio, en todas aquellas lesiones neoplásicas papilares metastásicas, más aún si se trata de mujeres jóvenes.

  10. Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease.

    Directory of Open Access Journals (Sweden)

    Ying-Ying Zheng

    Full Text Available BACKGROUND: C5L2 has been demonstrated to be a functional receptor of acylation-stimulating protein (ASP, which is a stimulator of triglyceride synthesis or glucose transport. However, little is known about the variations in the coding region of the C5L2 gene and their association with coronary artery disease (CAD. METHODOLOGY/PRINCIPAL FINDINGS: We identified a novel single nucleotide polymorphism (SNP, 698C>T (P233L, in exon 2 using a polymerase chain reaction direct-sequencing method. This nucleotide change causes the amino-acid order from proline to leucine at codon 233. We examined the role of this SNP for CAD using two independent case-control studies: one was in the Han population (492 CAD patients and 577 control subjects and the other was in the Uygur population (319 CAD patients and 554 control subjects. Heterozygote carriers of the 698CT genotype were more frequent among CAD patients than among controls not only in the Han population (7.3% versus 1.7% but also in the Uygur population (4.7% versus 1.6%. The odds ratio (OR for carriers of the 698CT genotype for CAD was 4.484 (95% confidence interval (CI: 2.197-9.174 in the Han group and 2.989 (95% CI: 1.292-6.909 in the Uygur population. After adjustment of confounding factors such as sex, age, smoking, alcohol consumption, hypertension, diabetes, as well as serum levels of triglyceride, total cholesterol, high-density lipoprotein, the difference remained significant in the Han group (P<0.001, OR = 6.604, 95% CI: 2.776-15.711 and in the Uygur group (P = 0.047, OR = 2.602, 95% CI: 1.015-6.671. CONCLUSION/SIGNIFICANCE: The 698CT genotype of C5L2 may be a genetic maker of CAD in the Han and Uygur population in western China.

  11. 基于多蚁群的并行ACO算法%Parallel ACO Algorithm Based on Multiple Ant Colony

    Institute of Scientific and Technical Information of China (English)

    夏鸿斌; 须文波; 刘渊

    2009-01-01

    This paper proposes and implements a new approach to parallel Ant Colony Optimization(ACO) algorithms by changing the behavior of ACO. In view of the shortcomings for ant algorithms' stagnant, by improving selection strategies, a new selection and search strategies with parallel adaptive mechanisms are implemented, so as to strengthen its global search capability, and the method of data parallel is used to reduce communication time between processors and get a better solution. The performance of the proposed parallel algorithm, applied to the Traveling Salesman Problem(TSP), is investigated and evaluated with respect to solution quality and computational effort. Experimental results demonstrate that the proposed algorithm outperforms the sequential ant colony system as well as the existing parallel ACO algorithms.%通过改变蚁群优化(ACO)算法行为,提出一种新的ACO并行化策略--并行多蚁群ACO算法.针对蚁群算法存在停滞现象的缺点,改进选择策略,实现具有自适应并行机制的选择和搜索策略,以加强其全局搜索能力.并行处理采用数据并行的手段,能减少处理器间的通信时间并获得更好的解.以对称TSP测试集为对象进行比较实验,结果表明,该算法相对于串行算法及现有的并行算法具有一定的优势.

  12. No ROI in ACO. Risk, expense of Medicare program has most for-profit groups shying away.

    Science.gov (United States)

    Kutscher, Beth

    2012-04-23

    For-profit healthcare companies aren't beating down the door to get in on Medicare ACOs. Several of the big chains say there is too much uncertainty about the experiment, and they're waiting to see how the program evolves. One company on the sideline is Capella Healthcare. Chairman and CEO Daniel Slipkovich, left, says there is a potential for high patient dropout rates and risks in population management. PMID:22571000

  13. Eight reasons payer interoperability and data sharing are essential in ACOs. Interoperability standards could be a prerequisite to measuring care.

    Science.gov (United States)

    Mookencherry, Shefali

    2012-01-01

    It makes strategic and business sense for payers and providers to collaborate on how to take substantial cost out of the healthcare delivery system. Acting independently, neither medical groups, hospitals nor health plans have the optimal mix of resources and incentives to significantly reduce costs. Payers have core assets such as marketing, claims data, claims processing, reimbursement systems and capital. It would be cost prohibitive for all but the largest providers to develop these capabilities in order to compete directly with insurers. Likewise, medical groups and hospitals are positioned to foster financial interdependence among providers and coordinate the continuum of patient illnesses and care settings. Payers and providers should commit to reasonable clinical and cost goals, and share resources to minimize expenses and financial risks. It is in the interest of payers to work closely with providers on risk-management strategies because insurers need synergy with ACOs to remain cost competitive. It is in the interest of ACOs to work collaboratively with payers early on to develop reasonable and effective performance benchmarks. Hence, it is essential to have payer interoperability and data sharing integrated in an ACO model. PMID:22352172

  14. Application of Celluclast 1.5L in apple pectin extraction.

    Science.gov (United States)

    Wikiera, Agnieszka; Mika, Magdalena; Starzyńska-Janiszewska, Anna; Stodolak, Bożena

    2015-12-10

    Pectins were extracted from apple pomace with Celluclast 1.5L at a dose of 25, 50 and 75 μl per 1g of material. In obtained pectin, the galacturonic acid (GalA) content, the neutral sugars (NS) profile, the degree of methylation (DM) and acetylation (DAc), the molecular mass, protein, ash and polyphenol levels as well as antioxidant and antitumor activity were determined. The lowest dose of enzymatic preparation resulted in the yield of pectin isolation comparable with acidic treatment (15.3%). Application of higher dose caused further, almost 4% increase in polymer recovery. Enzymatically isolated pectin was characterised by larger molecular mass and contained more GalA of higher DM and DAc than polymer extracted with acid. It was also richer in protein and polyphenols, and had different NS profile, which resulted in higher antiradical activity as well as the ability to inhibit the proliferation and invasion of Caco-2 adenocarcinoma cells.

  15. 3.5L V6 EcoBoost - democratization of sustainable engine technology

    Energy Technology Data Exchange (ETDEWEB)

    Kapp, Daniel; Schamel, Andreas; Hinds, Brett; Weaver, Corey [Ford Motor Co., Dearborn, MI (United States)

    2008-07-01

    The North American automotive industry is presently facing the challenge of a recently signed energy bill increasing corporate average fuel economy standards to 35 mpg (6.7 L/km) by 2020, inclusive of cars and trucks. The passing of this bill is coincident with crude oil costs hovering in the $130USD / barrel range, retail gasoline costs in the $4USD / gallon range, and mounting evidence on CO2 emissions and global warming. Ford Motor Company has anticipated these trends, has invested in the development of fuel efficient engine technologies, and is now deploying these technologies in volume to deliver both a meaningful and sustainable response to the above challenges. Leading the deployment curve is a technology publically announced as EcoBoost, representing the application of direct fuel injection and turbocharging to an advanced gasoline engine. Ford has previously reported the fundamentals of this technology which enables a significant fuel economy improvement via engine downsizing, and a significant performance improvement via engine dynamic response. As applied to 14 and V6 engine architectures, Ford has announced plans to deploy up to 750,000 EcoBoost engines worldwide by 2013 CY, with first application in the form of a 3.5L V6 EcoBoost engine in the 2010 MY Lincoln MKS luxury sedan. This paper summaries the development of the 3.5L V6 EcoBoost engine and its associated as-installed systems. Combustion, fuel, boost, and power conversion systems are discussed in detail with emphasis on the efficiency and value of these systems which enable a singular engine design to be applied across a wide range of applications. Engine performance and fuel economy assessments are also discussed and compared to conventional gasoline engines. (orig.)

  16. The Norma cluster (ACO3627): II. The near infrared K_s-band luminosity function

    CERN Document Server

    Skelton, R E; Kraan-Korteweg, R C

    2009-01-01

    A deep K_s-band photometric catalogue of galaxies at the core of the rich, nearby Norma cluster (ACO3627) is presented. The survey covers about 45 by 45 square arcmin (slightly less than 1/3 Abell radius), which corresponds to approx. 0.8 Mpc^2 at the adopted distance (v_cmb/H0) of 70 Mpc of this cluster. The survey is estimated to be complete to a magnitude of M_Ks <~ -19.5 mag. This extends into the dwarf regime, 6 magnitudes below M_Ks*. The catalogue contains 390 objects, 235 of which are classified as likely or definite galaxies and 155 as candidate galaxies. The Ks-band luminosity function (LF) is constructed from the photometric sample, using a spectroscopic subsample to correct for fore- and background contamination. We fit a Schechter function with a characteristic magnitude of M_Ks* = -25.39 \\pm 0.80 mag and faint-end slope of alpha = -1.26 \\pm 0.10 to the data. The shape of the LF is similar to those found in previous determinations of the cluster LF, in both optical and near infrared. The Schec...

  17. The cluster lens ACO 1703: redshift contrast and the inner profile

    CERN Document Server

    Saha, Prasenjit

    2008-01-01

    ACO 1703 is a cluster recently found to have a variety of strongly lensed objects: there is a quintuply-imaged system at z=0.888 and several other lensed objects from z=2.2 to 3.0 (the cluster itself is at z=0.28). It is not difficult to model the lens, as previous work has already done. However, lens models are generically non-unique. We generate ensembles of models to explore the non-uniqueness. When the full range of source redshifts is included, all models are close to \\rho \\propto r^{-1} out to 200 kpc. But if the quint is omitted, both shallower and steeper models (e.g., \\rho \\propto r^{-2}) are possible. The reason is that the redshift contrast between the quint and the other sources gives a good measurement of the enclosed mass at two different radii, thus providing a good estimate of the mass profile in between. This result supports universal profiles and explains why single-model approaches can give conflicting results. The mass map itself is elongated in the NW-SE direction, like the galaxy distrib...

  18. ACO-zeotype iron aluminum phosphates with variable Al/Fe ratios controlled by F⁻ ions.

    Science.gov (United States)

    Wang, Yanyan; Li, Yi; Wang, Lei; Zhang, Jingzhe; Yan, Yan; Li, Jiyang; Yu, Jihong; Wang, Jincheng; Xu, Ruren

    2011-03-01

    Three new iron aluminum phosphates |(C(2)H(10)N(2))(4)|[Fe(8 - x)Al(x)F(x)(H(2)O)(2 - x)(PO(4))(8)]·2H(2)O (χ = 1.64, 1.33, 0.80) with ACO-zeotype structures denoted as FeAPO-CJ66(a), FeAPO-CJ66(b), and FeAPO-CJ66(c), respectively, have been synthesized in the fluoride ion system. Their framework structures are made of double 4-ring (D4R) building units formed by the alternating connection of Fe(Al)O(4)F(O) trigonal bipyramids and PO(4) tetrahedra, which possess 3D intersecting 8-ring channels running along the [001], [010], and [100] directions. Fluoride ions or water molecules reside in the center of D4Rs, and diprotonated ethylenediamine cations and water molecules are occluded in the free space of channels to stabilize the whole structure. Notably, the Al/Fe ratios in the frameworks can be effectively controlled from 1/3.9 to 1/5.0 to 1/9.0 by adjusting the amounts of phosphoric acid and hydrofluoric acid added to the initial reaction mixture. Mössbauer and magnetic measurements show that the Fe ions in the compounds are bivalent and undergo antiferromagnetic ordering at room temperature.

  19. Task Scheduling problem in distributed systems considering communication cost and precedence by population-based ACO

    Directory of Open Access Journals (Sweden)

    Hossein Erfani

    2012-09-01

    Full Text Available With regard to the fact of the rapid growth of distributed systems and their large spectrum of usage of proposing and representing controlling solutions and optimization of task execution procedures is one of the most important issues. Task scheduling in distributed systems has determining role in improving efficiency in applications such as communication, routing, production plans and project management. The most important issues of good schedule are minimizing makespan and average of waiting time. However, the recent and previous effort usually focused on minimizing makespan. This article presents and analyze a new method based on Ant Colony Optimization (ACO algorithm with considerations to precedence and communication cost for task scheduling problem. In the mentioned method in addition to optimization of finish time, average of waiting time and number of needed processors are also optimized. In this method, by using of a new heuristic list, an algorithm based on ant colony is proposed. The results obtained in comparison with the latest similar models of random search algorithms, proves the higher efficiency of algorithm.

  20. Multivariate Morphometric Study on Apis florea Distributed in Iran

    OpenAIRE

    Özkan, Ayça; Gharleko, Mohammed M.; ÖZDEN, Berna; KANDEMİR, İrfan

    2009-01-01

    Multivariate Morphometric and Spatial Autocorrelation Analyses were performed to determine the morphometric variation in Apis florea colonies representing 13 localities from 4 states on the coastal north-south diagonal in Iran. New morphometric characters (hind wing length, hind wing width, and hind wing angles) were also measured to determine the usefulness of these characters for Apis florea. Analysis of variance of new morphometric characters showed that 7 out of the 8 hind wing variables ...

  1. Pengaruh Busur Api Terhadap Kekuatan Dielektrik Gas SF6

    OpenAIRE

    Jhony

    2011-01-01

    Bahan isolasi gas yang sering digunakan adalah gas SF6. Sifat –sifat dari gas SF6 ini tidak berwarna, tidak beracun, tidak berbau. Salah satu pemanfaatan dari gas SF6 ini sebagai bahan isolasi adalah pada pemutus tenaga (circuit breaker). Jika pemutus tenaga SF6 membuka, maka pada sela kontaknya akan terjadi busur api. Busur api akan menaikkan temperatur gas SF6 sehingga ada dugaan gas SF6 mengalami perubahan struktur kimia, sehingga sifat listriknya berubah. Tugas akhir ini ak...

  2. Drone competition at drone congregation areas in four Apis species

    OpenAIRE

    KOENIGER, Nikolaus; Koeniger, Gudrun; Gries, Michael; TINGEK, Salim

    2005-01-01

    International audience In Apis mellifera the estimated average number of drones visiting a drone congregation area (DCA) was 11 750 + 2 145. Drones of the species Apis cerana, A. koschevnikovi, A. dorsata and A. mellifera, which pursued a queen dummy moving in circular course, flew in a comet shaped formation. Median numbers of drones in a comet ranged from 9 drones (A. koschevnikovi) to 31 drones (A. mellifera). In none of the species we observed aggression between drones. Drone density b...

  3. Identification of Yersinia spp. with the API 20E system.

    OpenAIRE

    Archer, J R; Schell, R F; Pennell, D R; Wick, P D

    1987-01-01

    The ability of the API 20E system to identify 105 clinical isolates of Yersinia spp. was compared with those of conventional biochemical tests at 28 and 37 degrees C. Elimination of the Voges-Proskauer test (recorded as a negative result) increased the percentage of correct identifications for Yersinia spp. from 66 to 93% when the API 20E strips were incubated at 28 degrees C.

  4. 向日葵ACC氧化酶基因(HaACO1)的克隆及表达分析%Cloning and Expression Analysis of ACC Oxidase Gene (HaACO1) from Sunflower (Helianthus annuus L.)

    Institute of Scientific and Technical Information of China (English)

    孙瑞芬; 张艳芳; 郭树春; 于海峰; 李素萍; 乔慧蕾; 聂惠; 安玉麟

    2015-01-01

    目的:克隆向日葵中的ACC氧化酶基因(HaACO1),并对其进行生物信息学分析及盐胁迫表达分析,为理解向日葵ACC氧化酶生理功能并加强对ACO基因的利用奠定基础.方法:以前期从盐胁迫的内葵杂4号根中获得的ACC氧化酶基因片段4-4-7TDF(KM823963)为基础,通过RT-PCR和5'/3' RACE技术克隆ACO基因的全长cDNA序列,利用生物信息学软件对获得的eDNA序列及编码的蛋白质序列进行分析.同时采用PCR方法克隆基因组DNA(genemic DNA,gDNA)序列,并对其进行结构分析.利用实时荧光定量PCR分析NaCl胁迫下向日葵根、下胚轴、叶中HaACO1的表达量和不同NaCl浓度及不同胁迫时间下根中HaACO1的表达量.结果:HaACO1的cDNA序列全长为1 135bp,其开放阅读框为942bp,编码313个氨基酸.预测其分子质量和等电点分别为35.84kDa和5.13,基因登录号为KP966508.HaACO1与已报道的多种植物的ACO基因核苷酸序列及其推导的氨基酸序列有较高的相似性,分别为76% ~ 83%和77% ~88%.gDNA起始密码子至终止密码子序列长1 018bp,包含2个外显子和1个内含子,基因登录号为KP988289.实时荧光定量PCR分析表明向日葵HaACO1在不同器官及不同NaCl浓度、不同时间诱导下存在特异性表达差异.结论:获得的向日葵HaACO1是植物ACO家族成员之一,该基因应答盐胁迫具有独特的表达模式.

  5. GIANT API: an application programming interface for functional genomics

    Science.gov (United States)

    Roberts, Andrew M.; Wong, Aaron K.; Fisk, Ian; Troyanskaya, Olga G.

    2016-01-01

    GIANT API provides biomedical researchers programmatic access to tissue-specific and global networks in humans and model organisms, and associated tools, which includes functional re-prioritization of existing genome-wide association study (GWAS) data. Using tissue-specific interaction networks, researchers are able to predict relationships between genes specific to a tissue or cell lineage, identify the changing roles of genes across tissues and uncover disease-gene associations. Additionally, GIANT API enables computational tools like NetWAS, which leverages tissue-specific networks for re-prioritization of GWAS results. The web services covered by the API include 144 tissue-specific functional gene networks in human, global functional networks for human and six common model organisms and the NetWAS method. GIANT API conforms to the REST architecture, which makes it stateless, cacheable and highly scalable. It can be used by a diverse range of clients including web browsers, command terminals, programming languages and standalone apps for data analysis and visualization. The API is freely available for use at http://giant-api.princeton.edu. PMID:27098035

  6. GIANT API: an application programming interface for functional genomics.

    Science.gov (United States)

    Roberts, Andrew M; Wong, Aaron K; Fisk, Ian; Troyanskaya, Olga G

    2016-07-01

    GIANT API provides biomedical researchers programmatic access to tissue-specific and global networks in humans and model organisms, and associated tools, which includes functional re-prioritization of existing genome-wide association study (GWAS) data. Using tissue-specific interaction networks, researchers are able to predict relationships between genes specific to a tissue or cell lineage, identify the changing roles of genes across tissues and uncover disease-gene associations. Additionally, GIANT API enables computational tools like NetWAS, which leverages tissue-specific networks for re-prioritization of GWAS results. The web services covered by the API include 144 tissue-specific functional gene networks in human, global functional networks for human and six common model organisms and the NetWAS method. GIANT API conforms to the REST architecture, which makes it stateless, cacheable and highly scalable. It can be used by a diverse range of clients including web browsers, command terminals, programming languages and standalone apps for data analysis and visualization. The API is freely available for use at http://giant-api.princeton.edu. PMID:27098035

  7. Mining Effective Temporal Specifications from Heterogeneous API Data

    Institute of Scientific and Technical Information of China (English)

    Qian Wu; Guang-Tai Liang; Qian-Xiang Wang; Hong Mei

    2011-01-01

    Temporal specifications for Application Programming Interfaces (APIs) serve as an important basis for many defect detection tools.As these specifications are often not well documented,various approaches have been proposed to automatically mine specifications typically from API library source code or from API client programs.However,the library-based approaches take substantial computational resources and produce rather limited useful specifications,while the client-based approaches suffer from high false positive rates.To address the issues of existing approaches,we propose a novel specification miniug approach,called MineHEAD,which exploits heterogeneous API data,including information from API client programs as well as API library source code and comments,to produce effective specifications for defect detection with low cost.In particular,MineHEAD first applies client-based specification mining to produce a collection of candidate specifications,and then exploits the related library source code and comments to identify and refine the real specifications from the candidates.Our evaluation results on nine open source projects show that MineHEAD produces effective specifications with average precision of 97.2%.

  8. REGISTRO DE PARO CARDÍACO EN EL ADULTO Registries of outer hospital cardiac arrest in Bogotta-Colombia

    Directory of Open Access Journals (Sweden)

    Ricardo Navarro Vargas

    2005-07-01

    Full Text Available En nuestro país no hay un registro estandarizado de los eventos cardíacos que requieren reanimación cerebro-cardio-pulmonar (RCCP siguiendo los lineamientos "Utstein". El propósito de este estudio fue determinar la calidad de los registros extrahospitalarios de paro cardíaco en el adulto, en Bogotá-Colombia. Entre enero y marzo de 2005 se realizó un análisis retrospectivo de los casos que correspondieron a paro cardíaco en el adulto atendidos por el "Centro Regulador de Urgencias del Distrito (CRU". El estudio reveló un registro deficiente de los eventos que requirieron RCCP realizados a nivel prehospitalario, e identificó al trauma como causa de paro cardíaco en 22% de los casos, una cifra particularmente elevada si se compara con los reportes mundiales, que oscilan entre 5% y 8%. Recomienda la estandarización del registro de paro cardíaco en el adulto, para lo cual se sugiere utilizar el formato de registro que sigue los lineamientos "Utstein".There is not a standardized registry form of cardiac events requiring cardiopulmonary resuscitation (CPR in our country such as the Utstein style. The purpose of this study was to determine the quality of the registries of out-ofhospital cardiac arrests in Bogotá-Colombia. A retrospective survey of registries of cardiac events assisted by a regulatory center "Centro Regulador de Urgencias del Distrito (CRU" was conducted, between January and March, 2005. The study reveals a poor registry of outof-hospital cardiac arrest in Bogotá-Colombia, and identifies trauma as the cause of cardiac arrest in 22% of cases, a particularly high figure compared with 5-8% registered worldwide. Recommend the standardization of the registry form of out-of-hospital cardiac arrest and suggest to use the "uniform reporting of data following cardiac arrest - the Utstein style". The registry forms are shown in appendix 1-2. Suggestions are welcome.

  9. Kajian Bentuk Pengolahan dan Analisis Finansial Buah Api api (Avicennia officinalis L.) Sebagai Bahan Makanan dan Minuman di Kabupaten Deli Serdang

    OpenAIRE

    Sianturi, Gustinaria

    2013-01-01

    Penelitian ini bertujuan untuk mengidentifikasi bentuk pengolahan, tingkat kelayakan nilai finansial, dan strategi pengembangan usaha pengolahan buah api-api (Avicennia officinalis L.) di Dusun Paluh Merbau, Desa Tanjung Rejo, Kecamatan Percut Sei Tuan, Kabupaten Deli Serdang. Metode analisis yang digunakan adalah analisis deskriptif, analisis finansial, dan analisis strategi pengembangan usaha dengan menggunakan analisis SWOT. Hasil penelitian menunjukkan bahwa produk olahan buah api-...

  10. Comparative toxicity and hazards of pesticides to Apis and non-Apis bees. A chemometrical study.

    Science.gov (United States)

    Devillers, J; Decourtye, A; Budzinskid, H; Pham-Delègue, M H; Cluzeau, S; Maurin, G

    2003-01-01

    The adverse effects of 158 pesticides to the Honey bee (Apis mellifera), the alfalfa leafcutting bee (Megachile rotundata) and the alkali bee (Nomia melanderi) were compared by means of various linear and non-linear multivariate analyses. A comparison exercise including the bumble bee (Bombus spp.) was also performed from a more restricted set of 32 pesticides. While no difference of sensitivity was found between A. mellifera and Bombus spp., M. rotundata appeared the most susceptible to pesticides followed by N. melanderi. PMID:14758982

  11. Variance in spermatozoa number among Apis dorsata drones and among Apis mellifera drones

    OpenAIRE

    Koeniger, Gudrun; KOENIGER, Nikolaus; TINGEK, Salim; Phiancharoen, Mananya

    2005-01-01

    International audience Published estimates of the mean spermatozoa numbers for Apis dorsata drones vary from 1.2 × 106 and 2.4 × 106; the number of spermatozoa per individual drone vary from 0.22 × 106 to 2.65 × 106. Counts presented here revealed 1.19 × 106 + 0.25 × 106 spermatozoa in drones sampled near a colony and 1.59 × 106 + 0.18 × 106 in drones sampled at a drone congregation area (DCA) in Sabah, Borneo. The difference between the two sites is significant. Further, the degree of var...

  12. Reproduction of Varroa destructor in sealed worker bee brood cells of Apis mellifera carnica and Apis mellifera syriaca in Jordan

    OpenAIRE

    Alattal, Yehya; Rosenkranz, Peter; Zebitz, Claus Paul Walter

    2008-01-01

    The reproduction of the honey bee mite, Varroa destructor in sealed worker bee brood cells represents an important factor for the population development of this parasite in honey bee colonies. In this study, the relative infestation levels of worker brood cells, mite fertility (mites that lay at least one egg) and reproductive rate (number of viable adult daughters per mother mite) of Varroa mite in worker brood cells of Apis m. carnica and Apis m. syriaca were compared in fall 2003 and summe...

  13. The Apis mellifera Filamentous Virus Genome

    Directory of Open Access Journals (Sweden)

    Laurent Gauthier

    2015-07-01

    Full Text Available A complete reference genome of the Apis mellifera Filamentous virus (AmFV was determined using Illumina Hiseq sequencing. The AmFV genome is a double stranded DNA molecule of approximately 498,500 nucleotides with a GC content of 50.8%. It encompasses 247 non-overlapping open reading frames (ORFs, equally distributed on both strands, which cover 65% of the genome. While most of the ORFs lacked threshold sequence alignments to reference protein databases, twenty-eight were found to display significant homologies with proteins present in other large double stranded DNA viruses. Remarkably, 13 ORFs had strong similarity with typical baculovirus domains such as PIFs (per os infectivity factor genes: pif-1, pif-2, pif-3 and p74 and BRO (Baculovirus Repeated Open Reading Frame. The putative AmFV DNA polymerase is of type B, but is only distantly related to those of the baculoviruses. The ORFs encoding proteins involved in nucleotide metabolism had the highest percent identity to viral proteins in GenBank. Other notable features include the presence of several collagen-like, chitin-binding, kinesin and pacifastin domains. Due to the large size of the AmFV genome and the inconsistent affiliation with other large double stranded DNA virus families infecting invertebrates, AmFV may belong to a new virus family.

  14. Honeybee (Apis mellifera ligustica) drone embryo proteomes.

    Science.gov (United States)

    Li, Jianke; Fang, Yu; Zhang, Lan; Begna, Desalegn

    2011-03-01

    Little attention has been paid to the drone honeybee (Apis mellifera ligustica) which is a haploid individual carrying only the set of alleles that it inherits from its mother. Molecular mechanisms underlying drone embryogenesis are poorly understood. This study evaluated protein expression profiles of drone embryogenesis at embryonic ages of 24, 48 and 72h. More than 100 reproducible proteins were analyzed by mass spectrometry on 2D electrophoresis gels. Sixty-two proteins were significantly changed at the selected three experimental age points. Expression of the metabolic energy requirement-related protein peaked at the embryonic age of 48h, whereas development and metabolizing amino acid-related proteins expressed optimally at 72h. Cytoskeleton, protein folding and antioxidant-related proteins were highly expressed at 48 and 72h. Protein networks of the identified proteins were constructed and protein expressions were validated at the transcription level. This first proteomic study of drone embryogenesis in the honeybee may provide geneticists an exact timetable and candidate protein outline for further manipulations of drone stem cells. PMID:21172355

  15. Qualidade de vida de pacientes submetidos ao transplante cardíaco: aplicação da escala Whoqol-Bref Calidad de vida de pacientes sometidos a transplante cardíaco: aplicación de la escala Whoqol-Bref Quality of life of patients that had a heart transplant: application of Whoqol-Bref scale

    OpenAIRE

    Maria Isis Freire de Aguiar; Deisiana Rios Farias; Mabel Leite Pinheiro; Emília Soares Chaves; Isaura Letícia Tavares Palmeira Rolim; Paulo César de Almeida

    2011-01-01

    FUNDAMENTO: O sucesso do transplante cardíaco significa garantir a sobrevida dos pacientes com cardiopatia e permitir-lhes desenvolver suas atividades diárias. O transplante cardíaco apresenta-se como a primeira opção de tratamento na falência cardíaca, representando um aumento de sobrevida e qualidade de vida dos transplantados. OBJETIVO: Avaliar a qualidade de vida de pacientes submetidos ao transplante cardíaco através da aplicação de uma escala padronizada (Whoqol-Bref). MÉTODOS: Estudo e...

  16. Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera.

    Science.gov (United States)

    Gong, Zhiwen; Wang, Chao; Nieh, James C; Tan, Ken

    2016-07-01

    DNA methylation plays a key role in invertebrate acquisition and extinction memory. Honey bees have excellent olfactory learning, but the role of DNA methylation in memory formation has, to date, only been studied in Apis mellifera. We inhibited DNA methylation by inhibiting DNA methyltransferase (DNMT) with zebularine (zeb) and studied the resulting effects upon olfactory acquisition and extinction memory in two honey bee species, Apis cerana and A. mellifera. We used the proboscis extension reflex (PER) assay to measure memory. We provide the first demonstration that DNA methylation is also important in the olfactory extinction learning of A. cerana. DNMT did not reduce acquisition learning in either species. However, zeb bidirectionally and differentially altered extinction learning in both species. In particular, zeb provided 1h before acquisition learning improved extinction memory retention in A. mellifera, but reduced extinction memory retention in A. cerana. The reasons for these differences are unclear, but provide a basis for future studies to explore species-specific differences in the effects of methylation on memory formation.

  17. Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera.

    Science.gov (United States)

    Gong, Zhiwen; Wang, Chao; Nieh, James C; Tan, Ken

    2016-07-01

    DNA methylation plays a key role in invertebrate acquisition and extinction memory. Honey bees have excellent olfactory learning, but the role of DNA methylation in memory formation has, to date, only been studied in Apis mellifera. We inhibited DNA methylation by inhibiting DNA methyltransferase (DNMT) with zebularine (zeb) and studied the resulting effects upon olfactory acquisition and extinction memory in two honey bee species, Apis cerana and A. mellifera. We used the proboscis extension reflex (PER) assay to measure memory. We provide the first demonstration that DNA methylation is also important in the olfactory extinction learning of A. cerana. DNMT did not reduce acquisition learning in either species. However, zeb bidirectionally and differentially altered extinction learning in both species. In particular, zeb provided 1h before acquisition learning improved extinction memory retention in A. mellifera, but reduced extinction memory retention in A. cerana. The reasons for these differences are unclear, but provide a basis for future studies to explore species-specific differences in the effects of methylation on memory formation. PMID:27262427

  18. Transplante cardíaco humano: experiência inicial Human cardiac transplant: initial experience

    Directory of Open Access Journals (Sweden)

    Noedir A. G Stolf

    1986-12-01

    Full Text Available No Instituto do Coração, de março de 1985 a fevereiro de 1986,11 pacientes foram submetidos a transplante cardíaco ortotópico. Eram todos do sexo masculino, com idade variando de 39 a 54 anos; 6 com cardiopatia isquémica, 4 com cardiomiopatia dilatada e um com cardiomiopatia chagásica. Foi realizado estudo hemodinâmico através de catéter de Swan-Ganz, no pré-operatório, no pós-operatório, após estabilização na unidade de recuperação, e trinta ou mais dias após o transplante. Os dados mostram melhora progressiva em relação ao índice cardíaco, pressão em artéria pulmonar, pressão de capilar pulmonar, resistência vascular pulmonar e resistência vascular sistêmica. Três dos 11 pacientes apresentaram disfunção renal transitória no pós-operatório imediato e que regrediram até o 15º dia, enquanto que 2 pacientes apresentaram aumento moderado da creatinina plasmática. Apenas 3 pacientes não apresentaram qualquer episódio de rejeição; nos demais, esses episódios foram um diagnóstico histológico sem repercussões clínicas. Complicações infecciosas ocorreram em 9 pacientes e foram de fácil controle clínico. No pós-operatório tardio, a hipertensão esteve presente em 8 pacientes, sendo mais acentuada em 2 deles. Não houve óbitos, nesta série de pacientes; todos estão assintomáticos e os 6 primeiros estão trabalhando.At the Instituto do Cora��ão, University of São Paulo Medical School, 11 patients were submitted to heart transplantation from march 1985 up to february 1986. All were male, with ages of 39-59 years, 6 with coronary heart disease, 4 with dilated cardiomyopathy and 1 with Chagas cardiomyopathy. The patients were studied hemodynamically with a Swan-Ganz catheter pre-operatively, at the arrival in the intensive care unit, in the first postoperative day and 30 or more days after the transplant. The data showed that there was a progressive increase of cardiac index and decreases of

  19. Tumores cardíacos: 10 anos de experiência

    Directory of Open Access Journals (Sweden)

    Antônio Augusto MIANA

    1997-01-01

    Full Text Available Objetivo: Avaliar a experiência cirúrgica do grupo no tratamento dos tumores cardíacos durante o período de janeiro de 1985 a dezembro de 1994. Casuística e Métodos: De um total de 2268 cirurgias cardíacas com circulação extracorpórea realizadas neste período de 10 anos, 6 foram para extirpação de tumores intracavitários, perfazendo 0,26% dos casos. Destes, 3 eram mixomas de átrio esquerdo, 1 fibroelastoma papilar de valva mitral, 1 rabdomioma de ventrículo esquerdo e 1 fibroma de ventrículo esquerdo. A forma clínica de apresentação foi embolia sistêmica (3 casos ou insuficiência cardíaca (3 casos. O diagnóstico foi ecocardiográfico (5 casos e angiográfico (6 casos. Resultados: Todos os pacientes tiveram evolução imediata favorável, exceto 1 deles, com mixoma de átrio equerdo, que evoluiu com mediastinite e septicemia, vindo a falecer e constituindo o único óbito hospitalar. O seguimento pós-operatório tardio, obtido em 4 pacientes (15 a 111 meses - média 49 ± 36,8 meses, não detectou qualquer recidiva, encontrando-se todos em classe funcional I (NYHA. Conclusões: Os autores concluem que os tumores cardíacos são bastante raros, de fácil diagnóstico desde que considerados, na grande maioria benignos e que cursam favoravelmente com a extirpação cirúrgica.Purpose: To review the surgical experience of our group in the treatment of primary cardiac tumors, during a 10 year period beginning January 1985 till December 1994. Material and Methods: From a total of 2268 cardiac surgeries with the aid of extracorporeal circulation performed during this 10 year period, there were 6 cases of intracavitary tumor resection, an incidence of 0.26%. Three were myxomas of the left atrium, 1 papillary fibroelastoma of the mitral valve, 1 rhabdomyoma of the left ventricule and 1 fibroma of the left ventricle. Three patients presented systemic embolism and the other three congestive heart failure. The diagnosis was confirmed

  20. Changes in oxidative stress in transgenic RNAi ACO1 tomato fruit during ripening

    Science.gov (United States)

    Eglous, Najat Mohamed; Ali, Zainon Mohd; Hassan, Maizom; Zainal, Zamri

    2013-11-01

    Tomato (Solanum Lycopersicum L.) is the second most cultivated vegetable in the world and widely used as a system for studying the role of ethylene during fruit ripening. Our objective was to study the oxidative stress and antioxidative metabolism during ripening of non transgenic tomato and transgenic line-21 tomato which reduced ethylene. The line-21 of transgenic tomato plants (RNAi ACO1) had lower ethylene production and longer shelf-life more than 32 days as compared to the wild-type fruits which have very short shelf-life. In this study, tomato fruit were divided into five different stages (MG: mature green 5%, B: breaker 25%, T: turning 50%, O: orange75%, RR: red ripe100%). The activity of lipoxygenase (LOX) and lipid peroxidation (MDA) were measured to assess changes in oxidative stress. The LOX activity and MDA content decreased significantly obtaining 2.6-fold and 1.2-fold, respectively, as compared to the wild type fruit. However, superoxide dismutase (SOD) and catalase (CAT) activities were increased to 1.9 and 1.2 folds from the mature green to the fully ripe stage in transgenic tomatoes. Furthermore, the wild type tomato increases 1.3 in SOD and 1.6 in CAT activities. The overall results indicate that the wild type tomato fruit showed a faster rate of ripening, parallel to decline in the rate of enzymatic antioxidative systems as compared to the transgenic line-21 tomato fruit. In addition, the results show that the antioxidant capacity is improved during the ripening process and is accompanied by an increase in the oxidative stress.

  1. A quick guide to API 510 certified pressure vessel inspector syllabus example questions and worked answers

    CERN Document Server

    Matthews, Clifford

    2010-01-01

    The API Individual Certification Programs (ICPs) are well established worldwide in the oil, gas, and petroleum industries. This Quick Guide is unique in providing simple, accessible and well-structured guidance for anyone studying the API 510 Certified Pressure Vessel Inspector syllabus by summarizing and helping them through the syllabus and providing multiple example questions and worked answers.Technical standards are referenced from the API 'body of knowledge' for the examination, i.e. API 510 Pressure vessel inspection, alteration, rerating; API 572 Pressure vessel inspection; API

  2. Analisis Kinerja Operasional Kereta Api Sriwedari Ekspress Jurusan Solo - Yogya

    Directory of Open Access Journals (Sweden)

    Bayu Rosida Sumantri

    2014-03-01

    Full Text Available Pada bulan Nopember 2012 PT. Kereta Api Indonesia (Persero DAOP 6 Yogyakarta mengoperasikan Kereta Api Sriwedari Ekspress dengan rute perjalanan Yogya – Solo, hal ini dilakukan untuk mengantisipasi lonjakan penumpang akibat pemangkasan rute perjalanan Kereta Api Prambanan Ekspress dari tiga belas kali perjalanan menjadi enam kali perjalanan. Menurut Humas PT. Kereta Api Indonesia (Persero DAOP 6 Yogyakarta, dibukanya rute baru Kereta Api Sriwedari Ekspress yang melayani delapan kali perjalanan hanya  dengan rute Yogya – Solo saja diharapkan kereta ini dapat memfasilitasi pergerakan penumpang antar dua daerah tersebut. Namun untuk mengetahui kinerja dari kereta api ini sesuai dengan Surat Keterangan Dirjen Perhubungan Darat No. 687 Tahun 2002, perlu ditinjau dari segi faktor muat, jumlah penumpang yang diangkut, waktu tunggu penumpang, ketepatan waktu kedatangan dan keberangkatan kereta dan kenyamanan penumpang. Dalam penelitian digunakan metode survey untuk mendapatkan nilai – nilai dari kinerja kereta api Sriwedari berupa survey observasi atau pengamatan lapangan.  Adapun  analisis yang digunakan untuk perhitungan waktu tempuh, waktu henti dan waktu tunda menggunakan uji hipotesis 1 sample t-test, karena uji ini paling memenuhi untuk melihat diterima atau tidaknya keterlambatan dari waktu kereta. Sedangkan untuk perhitungan load factor dan kenyamanan duduk dan berdiri berdasarkan perhitungan kapasitas dari Vukan R. Vuchic. Dari hasil analisis didapatkan waktu tempuh rata-rata untuk arah Yogyakarta selama 1 jam 14 menit dan untuk arah Solo selama 1 jam 12 menit. Waktu henti yang didapat dari seluruh jadwal perjalanan kereta arah Yogyakarta sebesar 3 menit, untuk arah Solo sebesar 5 menit. Waktu tunda dari seluruh perjalanan kereta Api Sriwedari untuk arah Yogyakarta didapat nilai waktu tunda kedatangan sebesar 22 menit dan nilai waktu tunda keberangkatan sebesar 20 menit, untuk arah Solo didapat nilai waktu tunda kedatangan sebesar 34

  3. A knowledge discovery object model API for Java

    Directory of Open Access Journals (Sweden)

    Jones Steven JM

    2003-10-01

    Full Text Available Abstract Background Biological data resources have become heterogeneous and derive from multiple sources. This introduces challenges in the management and utilization of this data in software development. Although efforts are underway to create a standard format for the transmission and storage of biological data, this objective has yet to be fully realized. Results This work describes an application programming interface (API that provides a framework for developing an effective biological knowledge ontology for Java-based software projects. The API provides a robust framework for the data acquisition and management needs of an ontology implementation. In addition, the API contains classes to assist in creating GUIs to represent this data visually. Conclusions The Knowledge Discovery Object Model (KDOM API is particularly useful for medium to large applications, or for a number of smaller software projects with common characteristics or objectives. KDOM can be coupled effectively with other biologically relevant APIs and classes. Source code, libraries, documentation and examples are available at http://www.bcgsc.ca/bioinfo/software.

  4. SmartPATH: An Efficient Hybrid ACO-GA Algorithm for Solving the Global Path Planning Problem of Mobile Robots

    Directory of Open Access Journals (Sweden)

    Imen Châari

    2014-07-01

    Full Text Available Path planning is a fundamental optimization problem that is crucial for the navigation of a mobile robot. Among the vast array of optimization approaches, we focus in this paper on Ant Colony Optimization (ACO and Genetic Algorithms (GA for solving the global path planning problem in a static environment, considering their effectiveness in solving such a problem. Our objective is to design an efficient hybrid algorithm that takes profit of the advantages of both ACO and GA approaches for the sake of maximizing the chance to find the optimal path even under real-time constraints. In this paper, we present smartPATH, a new hybrid ACO-GA algorithm that relies on the combination of an improved ACO algorithm (IACO for efficient and fast path selection, and a modified crossover operator to reduce the risk of falling into a local minimum. We demonstrate through extensive simulations that smartPATH outperforms classical ACO (CACO, GA algorithms. It also outperforms the Dijkstra exact method in solving the path planning problem for large graph environments. It improves the solution quality up to 57% in comparison with CACO and reduces the execution time up to 83% as compared to Dijkstra for large and dense graphs. In addition, the experimental results on a real robot shows that smartPATH finds the optimal path with a probability up to 80% with a small gap not exceeding 1m in 98%.

  5. Independent chromatin binding of ARGONAUTE4 and SPT5L/KTF1 mediates transcriptional gene silencing.

    Directory of Open Access Journals (Sweden)

    M Jordan Rowley

    2011-06-01

    Full Text Available Eukaryotic genomes contain significant amounts of transposons and repetitive DNA elements, which, if transcribed, can be detrimental to the organism. Expression of these elements is suppressed by establishment of repressive chromatin modifications. In Arabidopsis thaliana, they are silenced by the siRNA-mediated transcriptional gene silencing pathway where long non-coding RNAs (lncRNAs produced by RNA Polymerase V (Pol V guide ARGONAUTE4 (AGO4 to chromatin and attract enzymes that establish repressive chromatin modifications. It is unknown how chromatin modifying enzymes are recruited to chromatin. We show through chromatin immunoprecipitation (ChIP that SPT5L/KTF1, a silencing factor and a homolog of SPT5 elongation factors, binds chromatin at loci subject to transcriptional silencing. Chromatin binding of SPT5L/KTF1 occurs downstream of RNA Polymerase V, but independently from the presence of 24-nt siRNA. We also show that SPT5L/KTF1 and AGO4 are recruited to chromatin in parallel and independently of each other. As shown using methylation-sensitive restriction enzymes, binding of both AGO4 and SPT5L/KTF1 is required for DNA methylation and repressive histone modifications of several loci. We propose that the coordinate binding of SPT5L and AGO4 creates a platform for direct or indirect recruitment of chromatin modifying enzymes.

  6. Sedação com sufentanil e clonidina em pacientes submetidos a cateterismo cardíaco

    Directory of Open Access Journals (Sweden)

    Anita Perpetua Carvalho Rocha

    2011-03-01

    Full Text Available FUNDAMENTO: A sedação para a realização de cateterismo cardíaco tem sido alvo de preocupação. Benzodiazepínicos, agonistas alfa-2 adrenérgicos e opioides são utilizados para esse fim, entretanto, cada um destes medicamentos possui vantagens e desvantagens. OBJETIVO: Avaliar a eficácia do sufentanil e da clonidina como sedativos em pacientes submetidos a cateterismo cardíaco, observando o impacto dos mesmos sobre os parâmetros hemodinâmicos e respiratórios, a presença de efeitos colaterais, além da satisfação do paciente e do hemodinamicista com o exame. MÉTODOS: Trata-se de um ensaio clínico prospectivo, duplo-cego, randomizado e controlado, que envolveu 60 pacientes que receberam 0,1 µg/kg de sufentanil ou 0,5 µg/kg de clonidina antes da realização do cateterismo cardíaco. O escore de sedação segundo a escala de Ramsay, a necessidade de utilização de midazolam, os efeitos colaterais, os parâmetros hemodinâmicos e respiratórios foram registrados, sendo os dados analisados em 06 diferentes momentos. RESULTADOS: O comportamento da pressão arterial, da frequência cardíaca e da frequência respiratória foi semelhante nos dois grupos, entretanto, no momento 2, os pacientes do grupo sufentanil (Grupo S apresentaram menor escore de sedação segundo a escala de Ramsay, e a saturação periférica da oxihemoglobina foi menor que o grupo clonidina (Grupo C no momento 6. Os pacientes do Grupo S apresentaram maior incidência de náusea e vômito pós-operatório que os pacientes do Grupo C. A satisfação dos pacientes foi maior no grupo clonidina. Os hemodinamicistas mostraram-se satisfeitos nos dois grupos. CONCLUSÃO: O sufentanil e a clonidina foram efetivos como sedativos em pacientes submetidos a cateterismo cardíaco.

  7. Nosema ceranae in drone honey bees (Apis mellifera).

    Science.gov (United States)

    Traver, Brenna E; Fell, Richard D

    2011-07-01

    Nosema ceranae is a microsporidian intracellular parasite of honey bees, Apis mellifera. Previously Nosema apis was thought to be the only cause of nosemosis, but it has recently been proposed that N. ceranae is displacing N. apis. The rapid spread of N. ceranae could be due to additional transmission mechanisms, as well as higher infectivity. We analyzed drones for N. ceranae infections using duplex qPCR with species specific primers and probes. We found that both immature and mature drones are infected with N. ceranae at low levels. This is the first report detecting N. ceranae in immature bees. Our data suggest that because drones are known to drift from their parent hives to other hives, they could provide a means for disease spread within and between apiaries. PMID:21621543

  8. Quality of life profile and psychometric properties of the EQ-5D-5L in HIV/AIDS patients

    Directory of Open Access Journals (Sweden)

    Tran Bach

    2012-11-01

    Full Text Available Abstract Objectives We assessed health-related quality of life (HRQOL, its associated factors, and examined measurement properties of the EuroQol - 5 Dimensions - 5 Levels (EQ-5D-5L in HIV/AIDS patients. Methods A cross-sectional multi-site survey was conducted in 1016 patients (age: 35.4 ± 7.0 years; 63.8% male in three epicenters of Vietnam. Internal consistency reliability, convergent validity, and discriminative validity of the EQ-5D-5L and a visual analogue scale (VAS were evaluated. Tobit censored regression models were used to identify predictors of HRQOL in HIV/AIDS patients. Results The mean EQ-5D-5L single index and VAS were 0.65 (95% Confidence Interval (CI = 0.63; 0.67 and 70.3 (95% CI = 69.2; 71.5. Cronbach’s alpha of five dimensions was 0.85. EQ-5D-5L has a good convergent validity with VAS (0.73. It discriminated patients at different HIV/AIDS stages, duration of ART, and CD4 cell count. Predictors of poorer HRQOL included being female, lower education level, unemployment, alcohol and drug use, CD4 Conclusion The EQ-5D-5L has good measurement properties in HIV/AIDS patients and holds potentials for monitoring ART outcomes. Integration of HRQOL measurement using EQ-5D-5L in HIV/AIDS clinical practice could be helpful for economic evaluation of HIV/AIDS interventions.

  9. Adhesions of extracellular surface-layer associated proteins in Lactobacillus M5-L and Q8-L.

    Science.gov (United States)

    Zhang, Yingchun; Xiang, Xinling; Lu, Qianhui; Zhang, Lanwei; Ma, Fang; Wang, Linlin

    2016-02-01

    Surface-layer associated proteins (SLAP) that envelop Lactobacillus paracasei ssp. paracasei M5-L and Lactobacillus casei Q8-L cell surfaces are involved in the adherence of these strain to the human intestinal cell line HT-29. To further elucidate some of the properties of these proteins, we assessed the yields and expressions of SLAP under different incubation conditions. An efficient and selective extraction of SLAP was obtained when cells of Lactobacillus were treated with 5 M LiCl at 37°C in aerobic conditions. The SLAP of Lactobacillus M5-L and Q8-L in cell extracts were visualized by SDS-PAGE and identified by Western blotting with sulfo-N-hydroxysuccinimide-biotin-labeled HT-29 cells as adhesion proteins. Atomic force microscopy contact imaging revealed that Lactobacillus strains M5-L and Q8-L normally display a smooth, homogeneous surface, whereas the surfaces of M5-L and Q8-L treated with 5 M LiCl were rough and more heterogeneous. Analysis of adhesion forces revealed that the initial adhesion forces of 1.41 and 1.28 nN obtained for normal Lactobacillus M5-L and Q8-L strains, respectively, decreased to 0.70 and 0.48 nN, respectively, following 5 M LiCl treatment. Finally, the dominant 45-kDa protein bands of Lactobacillus Q8-L and Lactobacillus M5-L were identified as elongation factor Tu and surface antigen, respectively, by liquid chromatography-tandem mass spectrometry.

  10. Association of Immune and Metabolic Receptors C5aR and C5L2 with Adiposity in Women

    Directory of Open Access Journals (Sweden)

    Pegah Poursharifi

    2014-01-01

    Full Text Available Adipose tissue receptors C5aR and C5L2 and their heterodimerization/functionality and interaction with ligands C5a and acylation stimulating protein (ASP have been evaluated in cell and rodent studies. Their contribution to obesity factors in humans remains unclear. We hypothesized that C5a receptors, classically required for host defense, are also associated with adiposity. Anthropometry and fasting blood parameters were measured in 136 women divided by body mass index (BMI: normal/overweight (≤30 kg/m2; n = 34, obese I (≤45 kg/m2; n = 33, obese II (≤51 kg/m2; n = 33, and obese III (≤80 kg/m2; n = 36. Subcutaneous and omental adipose tissue C5aR and C5L2 expression were analysed. C5L2 expression was comparable between subcutaneous and omental across all BMI groups. Plasma ASP and ASP/omental C5L2 expression increased with BMI (P < 0.001 and P < 0.01, resp.. While plasma C5a was unchanged, C5aR expression decreased with increasing BMI in subcutaneous and omental tissues (P < 0.01 and P < 0.05, resp., with subcutaneous omental depots. Omental C5L2/C5aR ratio increased with BMI (P < 0.01 with correlations between C5L2/C5aR and waist circumference, HDL-C, and adiponectin. Tissue and BMI differences in receptors and ligands, particularly in omental, suggest relationship to metabolic disturbances and highlight adipose-immune interactions.

  11. ADS 2.0: new architecture, API and services

    OpenAIRE

    Chyla, Roman; Accomazzi, Alberto; Holachek, Alexandra; Grant, Carolyn S.; Elliott, Jonathan; Henneken, Edwin A.; Thompson, Donna M.; Kurtz, Michael J.; Murray, Stephen S.; Sudilovsky, Vladimir

    2015-01-01

    The ADS platform is undergoing the biggest rewrite of its 20-year history. While several components have been added to its architecture over the past couple of years, this talk will concentrate on the underpinnings of ADS's search layer and its API. To illustrate the design of the components in the new system, we will show how the new ADS user interface is built exclusively on top of the API using RESTful web services. Taking one step further, we will discuss how we plan to expose the treasur...

  12. Pro JPA 2 Mastering the Java Persistence API

    CERN Document Server

    Schincariol, Merrick

    2010-01-01

    Pro JPA 2 introduces, explains, and demonstrates how to use the new Java Persistence API (JPA). JPA provides Java developers with both the knowledge and insight needed to write Java applications that access relational databases through JPA. Authors Mike Keith and Merrick Schincariol take a hands-on approach to teaching by giving examples to illustrate each new concept of the API and showing how it is used in practice. All of the examples use a common model from an overriding sample application, giving readers a context from which to start and helping them to understand the examples within an a

  13. Parameter-Free Probabilistic API Mining at GitHub Scale

    OpenAIRE

    Fowkes, Jaroslav; Sutton, Charles

    2015-01-01

    Existing API mining algorithms are not yet practical to use as they require expensive parameter tuning and the returned set of API calls can be large, highly redundant and difficult to understand. In an attempt to remedy these shortcomings we present PAM (Probabilistic API Miner), a near parameter-free probabilistic algorithm for mining the most informative API call patterns. We show that PAM significantly outperforms both MAPO and UPMiner, achieving 70% test-set precision, at retrieving rele...

  14. A method for designing fiberglass sucker-rod strings with API RP 11L

    Energy Technology Data Exchange (ETDEWEB)

    Jennings, J.W.; Laine, R.E. (Texas A and M University (US))

    1991-02-01

    This paper presents a method for using the API recommended practice for the design of sucker-rod pumping systems with fiberglass composite rod strings. The API method is useful for obtaining quick, approximate, preliminary design calculations. Equations for calculating all the composite material factors needed in the API calculations are given.

  15. A method for designing fiberglass sucker-rod strings with API RP 11L

    International Nuclear Information System (INIS)

    This paper presents a method for using the API recommended practice for the design of sucker-rod pumping systems with fiberglass composite rod strings. The API method is useful for obtaining quick, approximate, preliminary design calculations. Equations for calculating all the composite material factors needed in the API calculations are given

  16. Interacciones entre dispositivos cardíacos implantables y modalidades fisioterapéuticas: ¿Mito o realidad?

    Directory of Open Access Journals (Sweden)

    Genevieve C. Digby

    2011-04-01

    Full Text Available La fisioterapia se ha transformado en una especialidad que claramente incide en la calidad de vida de nuestros pacientes. En poblaciones añosas, el uso de fisioterapia incluye múltiples modalidades para un alto número de distintas enfermedades. Varios informes sobre posibles interacciones negativas entre las distintas modalidades de fisioterapia y los dispositivos cardíacos implantables (marcapasos y cardiodesfibriladores han sido publicados en los últimos aňos. A pesar de ello, existe muy poca evidencia y guías precisas para identificar cuáles son las modalidades de fisioterapia seguras a utilizar en esta población de pacientes. En la siguiente revisión, nos propusimos resumir las interacciones documentadas entre fisioterapia y dispositivos cardíacos implantables (DCI, discutir el estándar actual de estas prácticas e identificar las principales consideraciones que existen desde la perspectiva de un servicio de electrofisiología cardíaca, para el tratamiento adecuado en estos pacientes. Finalmente, abogamos por fortalecer la colaboración entre fisioterapeutas y electrofisiólogos, con el fin de asegurar una óptima y segura atención de este grupo de pacientes.

  17. Aplicações do ecocardiograma intracardíaco no laboratório de eletrofisiologia

    Directory of Open Access Journals (Sweden)

    Eduardo B. Saad

    2011-01-01

    Full Text Available O ecocardiograma intracardíaco (EIC proporciona uma visualização detalhada das estruturas cardíacas, combinada a informações hemodinâmicas, permitindo posicionamento acurado e em tempo real do posicionamento dos cateteres, redução do tempo de exposição à fluoroscopia, e a monitorização de complicações agudas durante o procedimento eletrofisiológico (ex. formação de trombos, derrame pericárdico, tamponamento cardíaco. Por isso, a sua utilização tem sido crescente, principalmente na ablação da fibrilação atrial e das arritmias ventriculares. Na ablação de fibrilação atrial demonstra grande utilidade por fornecer dados anatômicos do átrio esquerdo e veias pulmonares, auxiliar nas punções transeptais, localizar o óstio e antro das veias pulmonares, monitorizar a lesão tecidual durante a aplicação de radiofrequência (RF, prevenir injúria esofágica através da monitorização das lesões por RF na parede posterior do átrio esquerdo e avaliar o fluxo das veias pulmonares.

  18. Manejo de las dislipidemias en pacientes cardíacos trasplantados. Hallazgos sobre nuevos factores de riesgo

    Directory of Open Access Journals (Sweden)

    Walter Masson

    2008-01-01

    Full Text Available En pacientes cardíacos trasplantados, el desarrollo de enfermedad vascular coronaria es una complicación frecuente y la dislipidemia es uno de los predictores más importantes. Los inmunosupresores predisponen a las dislipidemias y dificultan la utilización de hipolipemiantes. En este grupo particular de pacientes se recomienda alcanzar las metas terapéuticas de prevención secundaria. Las estatinas son los hipolipemiantes de elección. No existen recomendaciones claras sobre nuevos factores de riesgo, como la homocisteína y la lipoproteína (a [Lp(a].Con el objetivo de conocer el perfil lipídico, la prevalencia de homocisteinemia y de Lp(a elevadas, el cumplimiento de las metas terapéuticas y la tolerancia a la medicación, se incluyeron en el estudio 23 pacientes cardíacos trasplantados. Los resultados mostraron que el cumplimiento de las metas lipídicas fue aceptable y que el 65% recibía tratamiento hipolipemiante. El uso de estatinas fue seguro. Se encontró una prevalencia alta de homocisteína y Lp(a elevadas. Su implicación en la modificación del tratamiento se desconoce.

  19. Transient absorption spectroscopy in biology using the Super-ACO storage ring FEL and the synchrotron radiation combination

    CERN Document Server

    Renault, E; De Ninno, G; Garzella, D; Hirsch, M; Nahon, L; Nutarelli, D

    2001-01-01

    The Super-ACO storage ring FEL, covering the UV range down to 300 nm with a high average power (300 mW at 350 nm) together with a high stability and long lifetime, is a unique tool for the performance of users applications. We present here the first pump-probe two color experiments on biological species using a storage ring FEL coupled to the synchrotron radiation. The intense UV pulse of the Super-ACO FEL is used to prepare a high initial concentration of chromophores in their first singlet electronic excited state. The nearby bending magnet synchrotron radiation provides, on the other hand a pulsed, white light continuum (UV-IR), naturally synchronized with the FEL pulses and used to probe the photochemical subsequent events and the associated transient species. We have demonstrated the feasibility with a dye molecule (POPOP) observing a two-color effect, signature of excited state absorption and a temporal signature with Acridine. Applications on various chromophores of biological interest are carried out,...

  20. Trasplante cardíaco y de médula ósea en un paciente

    Directory of Open Access Journals (Sweden)

    CÉSAR BELZITI

    2009-01-01

    Full Text Available RESUMENLa amiloidosis es una enfermedad infiltrativa sistémica que compromete al corazón y representauna causa importante de miocardiopatía restrictiva.Se describe el caso de un paciente masculino de 35 años con insuficiencia cardíaca avanzadasecundaria a miocardiopatía infiltrativa por depósito amiloide. Durante su evaluación serealizó diagnóstico de neoplasia de células plasmáticas. Debido a la rápida progresión de lossíntomas, el deterioro de la función ventricular y la incapacidad para tolerar el tratamientoadecuado para su enfermedad hematológica, se realizó trasplante cardíaco seguido de trasplanteautólogo de médula ósea sin complicaciones. La presentación de este caso constituyela primera comunicación en nuestro país de trasplante cardíaco seguido de trasplante demédula ósea como tratamiento de la amiloidosis cardíaca.REV ARGENT CARDIOL 2009;77;309-311.

  1. Acute Care of At-Risk Newborns (ACoRN): quantitative and qualitative educational evaluation of the program in a region of China

    OpenAIRE

    Singhal Nalini; Lockyer Jocelyn; Fidler Herta; Aziz Khalid; McMillan Douglas; Qiu Xiangming; Ma Xiaolu; Du Lizhong; Lee Shoo K

    2012-01-01

    Abstract Background The Acute Care of at-Risk Newborns (ACoRN) program was developed in Canada for trained health care providers for the identification and management of newborns who are at-risk and/or become unwell in the first few hours or days after birth. The ACoRN process follows an 8-step framework that enables the evaluation and management of babies irrespective of the experience or expertise of the caregiving individual or team. This study assesses the applicability of the program to ...

  2. The effects of Bt Cry1Ah toxin on worker honeybees (Apis mellifera ligustica and Apis cerana cerana)

    OpenAIRE

    Dai, Ping-Li; Wei ZHOU; Zhang, Jie; Jiang, Wei-Yu; Wang, Qiang; Cui, Hong-Juan; Sun, Ji-Hu; Wu, Yan-Yan; Zhou, Ting

    2012-01-01

    International audience We conducted feeding trials in a laboratory setting to test for possible adverse effects of Cry1Ah toxin mixed thoroughly into sugar syrup (60% w/v sucrose solution) at three concentrations (10 μg/mL, 10 ng/mL, and 1 ng/mL) on the survival, pollen consumption, and hypopharyngeal gland mass of Apis mellifera ligustica and Apis cerana cerana. No significant differences in the survival of A. mellifera or A. cerana were found among groups fed on sugar syrup with or witho...

  3. Imunocitomonitorização em pacientes transplantados cardíacos Immunocytomonitorization in patients submitted to cardiac transplantation

    Directory of Open Access Journals (Sweden)

    Ricardo Manrique

    1990-04-01

    Full Text Available A técnica de Imunocitomonitorização (CIM - Cytologrcal and Immunologic Monitoring, fundamenta-se na avaliação de mudanças nas subpopulações de linfócitos e seus precursores celulares, durante o processo rejeição aguda. O método avalia a ativação precoce pela contagem do número de: linfócitos ativados, linfoblastos e prolinfócitos (aqui chamados em conjunto de linfócitos ativos, quando esses se apresentam acima do limite superior normal. Utilizamos essa técnica para seguimento e controle da atividade da imunologia celular em 9 pacientes transplantados cardíacos. Também foram submetidos ao CIM para verificar a faixa de normalidade de ativação linfocítica 20 voluntários normais e cinco pacientes candidatos ao transplante cardíaco. Ambos os grupos não tinham antecedentes de quadro de infecção ou alteração imunológica. Para obtenção do controle positivo, testamos 10 pacientes com infecção bacteriana ou virai, previamente diagnosticados por exames bacterianos e/ou sorológicos. Foram observados valores de 1,8% de linfócitos ativos nos indivíduos normais e 3,2% nos candidatos ao transplante cardíaco. Dos 63 testes realizados nos transplantados cardíacos, quatro deles se mostraram positivos, onde três desses tratavam-se de casos de infecção e um confirmado como processo de rejeição aguda em evolução. O tempo médio necessário para a realização da CIM foi de aproximadamente duas horas. A técnica utiliza mostrou-se valiosa no reconhecimento imunológico dos pacientes transplantados cardíacos, pela sua sensibilidade diagnostica, baixo custo e rapidez.The immunocytomonitorization technique (CIM - Cytological and Immunologic Monitoring is based on assessment of changes in the subpopulations of lyphocyte and their precursor cells, while under the acute rejection. The method assesses the precocious activation by counting the number of the lymphocytes normal and actives, lymphoblasts and prolymphocytes (here

  4. Fertile diploid drones in africanized honeybees, Apis mellifera adansonii.

    Science.gov (United States)

    Chaud-Netto, J

    1977-02-15

    59 diploid drones of Apis mellifera adansonii, 12-37 days old, were tested for the presence of semen after provoked ejaculation; 13 drones ejaculated semen enough to be used in an instrumental insemination, but only three on them (5%) furnished 1 mm3 of semen. The problems referring to the attainment of descendants from the 2n drones are briefly discussed.

  5. Sperm use economy of honeybee (Apis mellifera) queens

    DEFF Research Database (Denmark)

    Baer, Boris; Collins, Jason; Maalaps, Kristiina;

    2016-01-01

    the fecundity and longevity of queens and therefore colony fitness. We quantified the number of sperm that honeybee (Apis mellifera) queens use to fertilize eggs. We examined sperm use in naturally mated queens of different ages and in queens artificially inseminated with different volumes of semen. We found...

  6. Biophysics of the subgenual organ of the honeybee, Apis mellifera

    DEFF Research Database (Denmark)

    Kilpinen, Ole; Storm, Jesper

    1997-01-01

    The subgenual organ of the honeybee (Apis mellifera) is suspended in a haemolymph channel in the tibia of each leg. When the leg is accelerated, inertia causes the haemolymph (and the subgenual organ) to lag behind the movement of the rest of the leg. The magnitude of this phase lag determines...

  7. Standard methods for research on apis mellifera gut symbionts

    Science.gov (United States)

    Gut microbes can play an important role in digestion, disease resistance, and the general health of animals, but little is known about the biology of gut symbionts in Apis mellifera. This paper is part of a series on honey bee research methods, providing protocols for studying gut symbionts. We desc...

  8. The MPO API: A tool for recording scientific workflows

    Energy Technology Data Exchange (ETDEWEB)

    Wright, John C., E-mail: jcwright@mit.edu [MIT Plasma Science and Fusion Center, Cambridge, MA (United States); Greenwald, Martin; Stillerman, Joshua [MIT Plasma Science and Fusion Center, Cambridge, MA (United States); Abla, Gheni; Chanthavong, Bobby; Flanagan, Sean; Schissel, David; Lee, Xia [General Atomics, San Diego, CA (United States); Romosan, Alex; Shoshani, Arie [Lawrence Berkeley Laboratory, Berkeley, CA (United States)

    2014-05-15

    Highlights: • A description of a new framework and tool for recording scientific workflows, especially those resulting from simulation and analysis. • An explanation of the underlying technologies used to implement this web based tool. • Several examples of using the tool. - Abstract: Data from large-scale experiments and extreme-scale computing is expensive to produce and may be used for high-consequence applications. The Metadata, Provenance and Ontology (MPO) project builds on previous work [M. Greenwald, Fusion Eng. Des. 87 (2012) 2205–2208] and is focused on providing documentation of workflows, data provenance and the ability to data-mine large sets of results. While there are important design and development aspects to the data structures and user interfaces, we concern ourselves in this paper with the application programming interface (API) – the set of functions that interface with the data server. Our approach for the data server is to follow the Representational State Transfer (RESTful) software architecture style for client–server communication. At its core, the API uses the POST and GET methods of the HTTP protocol to transfer workflow information in message bodies to targets specified in the URL to and from the database via a web server. Higher level API calls are built upon this core API. This design facilitates implementation on different platforms and in different languages and is robust to changes in the underlying technologies used. The command line client implementation can communicate with the data server from any machine with HTTP access.

  9. The Automatic Start Method of Application Program Using API

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    This paper introduces on a method about the au-tomactic start of application program. Through defining Registryby API function, the automatic start of specified application pro-gram is fulfilled when Windows98 is taking action. It gives facil-ities to many computer application works.

  10. Standard methods for research on Apis mellifera gut symbionts

    Science.gov (United States)

    Gut microbes can play an important role in digestion, disease resistance, and the general health of animals, but little is known about the biology of gut symbionts in Apis mellifera. This paper is part of a series on honey bee research methods, providing protocols for studying gut symbionts. We desc...

  11. PrismTech Data Distribution Service Java API Evaluation

    Science.gov (United States)

    Riggs, Cortney

    2008-01-01

    My internship duties with Launch Control Systems required me to start performance testing of an Object Management Group's (OMG) Data Distribution Service (DDS) specification implementation by PrismTech Limited through the Java programming language application programming interface (API). DDS is a networking middleware for Real-Time Data Distribution. The performance testing involves latency, redundant publishers, extended duration, redundant failover, and read performance. Time constraints allowed only for a data throughput test. I have designed the testing applications to perform all performance tests when time is allowed. Performance evaluation data such as megabits per second and central processing unit (CPU) time consumption were not easily attainable through the Java programming language; they required new methods and classes created in the test applications. Evaluation of this product showed the rate that data can be sent across the network. Performance rates are better on Linux platforms than AIX and Sun platforms. Compared to previous C++ programming language API, the performance evaluation also shows the language differences for the implementation. The Java API of the DDS has a lower throughput performance than the C++ API.

  12. The MPO API: A tool for recording scientific workflows

    International Nuclear Information System (INIS)

    Highlights: • A description of a new framework and tool for recording scientific workflows, especially those resulting from simulation and analysis. • An explanation of the underlying technologies used to implement this web based tool. • Several examples of using the tool. - Abstract: Data from large-scale experiments and extreme-scale computing is expensive to produce and may be used for high-consequence applications. The Metadata, Provenance and Ontology (MPO) project builds on previous work [M. Greenwald, Fusion Eng. Des. 87 (2012) 2205–2208] and is focused on providing documentation of workflows, data provenance and the ability to data-mine large sets of results. While there are important design and development aspects to the data structures and user interfaces, we concern ourselves in this paper with the application programming interface (API) – the set of functions that interface with the data server. Our approach for the data server is to follow the Representational State Transfer (RESTful) software architecture style for client–server communication. At its core, the API uses the POST and GET methods of the HTTP protocol to transfer workflow information in message bodies to targets specified in the URL to and from the database via a web server. Higher level API calls are built upon this core API. This design facilitates implementation on different platforms and in different languages and is robust to changes in the underlying technologies used. The command line client implementation can communicate with the data server from any machine with HTTP access

  13. Infra-Population and -Community Dynamics of the Parasites Nosema apis and Nosema ceranae, and Consequences for Honey Bee (Apis mellifera) Hosts

    OpenAIRE

    Williams, Geoffrey R; Dave Shutler; Burgher-MacLellan, Karen L.; Rogers, Richard E. L.

    2014-01-01

    Nosema spp. fungal gut parasites are among myriad possible explanations for contemporary increased mortality of western honey bees (Apis mellifera, hereafter honey bee) in many regions of the world. Invasive Nosema ceranae is particularly worrisome because some evidence suggests it has greater virulence than its congener N. apis. N. ceranae appears to have recently switched hosts from Asian honey bees (Apis cerana) and now has a nearly global distribution in honey bees, apparently displacing ...

  14. Qualification and Certification Requirements of Steel Tube Nondestructive Testing Personnel in API Product Standards%产品标准中钢管无损检测人员资格鉴定要求

    Institute of Scientific and Technical Information of China (English)

    张黎; 赵仁顺

    2016-01-01

    依据API SPEC 5 CT «套管和油管规范»和 API SPEC 5 L «管线管规范»标准对无损检测(NDT)人员资格的要求,对 ISO 9712:2012«无损检测———人员资格鉴定与认证»标准和 ISO 11484:2009«钢材产品———雇主的无损检测人员资格制度»标准的异同进行了分析,分析认为,两个标准规定的无损检测方法、无损检测人员资格鉴定等级和对雇主职责的要求不同,但对无损检测人员的视力要求、无损检测人员的操作授权及资格证书有效期的规定是一致的。%According to the nondestructive testing (NDT)personnel qualification requirements specified by API Spec 5CT and API Spec 5L,an analysis was made of the similarities and differences between the standards of ISO 9712:2012 and ISO 11484:2009.The analysis concluded that the two standards showed differences in NDT methods,nondestructive testing personnel qualification level and responsibilities requirement for employers,but they had the same requirement for the vision of NDT personnel,nondestructive testing personnel operating licenses and the valid period of time of qualification certificate.

  15. Intelligent Search Method Based ACO Techniques for a Multistage Decision Problem EDP/LFP

    Directory of Open Access Journals (Sweden)

    Mostefa RAHLI

    2006-07-01

    the algorithm getting to him a rate preferably more or less justifiable. In operational research, this subject is known under the name of CPO [14] (combinatory problem optimization.The choice of a numerical method to use for a merged case study and calculation of the LFP/Fitting/EDP what is [7, 8, 9, 10, 18, 19, 20] (in theoretical form of a problem compensates the final decision to adopt and a strategy of optimal production (which is a practical problem form and the final task most wanted.Each method is imposed by:· The algorithm complexity.· In an application gathering all calculations, the number of uses of method compared to the total number of later issues.· The maximum number of iterations for a given use.· The maximum iterations count allowed for this algorithm kind.· The limitations of the algorithm such as: applicability of a method (algorithm adapted or not to the problem; does the problem constrained or not; problem dimension or order N (N ≤ Nmax; the algorithm stability.It's well-known that for an approached calculation method, the propagation of errors strongly conditions the need of making its adequate choice and if it can be adopted compared to others for the same area.More is the number of the elementary operations is large more the final result misses precision and especially if the finality of the study is a responsible decision to make and a satisfaction of constraints and multiple conditions. Our study proposes an inference based solution (AI with the use of ACO technique (Ant colony Optimization2.

  16. Host Specificity in the Honeybee Parasitic Mite, Varroa spp. in Apis mellifera and Apis cerana.

    Science.gov (United States)

    Beaurepaire, Alexis L; Truong, Tuan A; Fajardo, Alejandro C; Dinh, Tam Q; Cervancia, Cleofas; Moritz, Robin F A

    2015-01-01

    The ectoparasitic mite Varroa destructor is a major global threat to the Western honeybee Apis mellifera. This mite was originally a parasite of A. cerana in Asia but managed to spill over into colonies of A. mellifera which had been introduced to this continent for honey production. To date, only two almost clonal types of V. destructor from Korea and Japan have been detected in A. mellifera colonies. However, since both A. mellifera and A. cerana colonies are kept in close proximity throughout Asia, not only new spill overs but also spill backs of highly virulent types may be possible, with unpredictable consequences for both honeybee species. We studied the dispersal and hybridisation potential of Varroa from sympatric colonies of the two hosts in Northern Vietnam and the Philippines using mitochondrial and microsatellite DNA markers. We found a very distinct mtDNA haplotype equally invading both A. mellifera and A. cerana in the Philippines. In contrast, we observed a complete reproductive isolation of various Vietnamese Varroa populations in A. mellifera and A. cerana colonies even if kept in the same apiaries. In light of this variance in host specificity, the adaptation of the mite to its hosts seems to have generated much more genetic diversity than previously recognised and the Varroa species complex may include substantial cryptic speciation. PMID:26248192

  17. Host Specificity in the Honeybee Parasitic Mite, Varroa spp. in Apis mellifera and Apis cerana.

    Directory of Open Access Journals (Sweden)

    Alexis L Beaurepaire

    Full Text Available The ectoparasitic mite Varroa destructor is a major global threat to the Western honeybee Apis mellifera. This mite was originally a parasite of A. cerana in Asia but managed to spill over into colonies of A. mellifera which had been introduced to this continent for honey production. To date, only two almost clonal types of V. destructor from Korea and Japan have been detected in A. mellifera colonies. However, since both A. mellifera and A. cerana colonies are kept in close proximity throughout Asia, not only new spill overs but also spill backs of highly virulent types may be possible, with unpredictable consequences for both honeybee species. We studied the dispersal and hybridisation potential of Varroa from sympatric colonies of the two hosts in Northern Vietnam and the Philippines using mitochondrial and microsatellite DNA markers. We found a very distinct mtDNA haplotype equally invading both A. mellifera and A. cerana in the Philippines. In contrast, we observed a complete reproductive isolation of various Vietnamese Varroa populations in A. mellifera and A. cerana colonies even if kept in the same apiaries. In light of this variance in host specificity, the adaptation of the mite to its hosts seems to have generated much more genetic diversity than previously recognised and the Varroa species complex may include substantial cryptic speciation.

  18. Expression Study of LeGAPDH, LeACO1, LeACS1A, and LeACS2 in Tomato Fruit (Solanum lycopersicum

    Directory of Open Access Journals (Sweden)

    Pijar Riza Anugerah

    2015-10-01

    Full Text Available Tomato is a climacteric fruit, which is characterized by ripening-related increase of respiration and elevated ethylene synthesis. Ethylene is the key hormone in ripening process of climacteric fruits. The objective of this research is to study the expression of three ethylene synthesis genes: LeACO1, LeACS1A, LeACS2, and a housekeeping gene LeGAPDH in ripening tomato fruit. Specific primers have been designed to amplify complementary DNA fragment of LeGAPDH (143 bp, LeACO1 (240 bp, LeACS1A (169 bp, and LeACS2 (148 bp using polymerase chain reaction. Nucleotide BLAST results of the complementary DNA fragments show high similarity with LeGAPDH (NM_001247874.1, LeACO1 (NM_001247095.1, LeACS1A(NM_001246993.1, LeACS2 (NM_001247249.1, respectively. Expression study showed that LeACO1, LeACS1A, LeACS2, and LeGAPDH genes were expressed in ripening tomato fruit. Isolation methods, reference sequences, and primers used in this study can be used in future experiments to study expression of genes responsible for ethylene synthesis using quantitative polymerase chain reaction and to design better strategy for controlling fruit ripening in agroindustry.

  19. Meta-heurística ACO (Ant Colony Optimization) para la resolución de problemas en líneas de producción

    OpenAIRE

    Bautista Valhondo, Joaquín; Bretón Blas, Javier; Fernández Ros, José Antonio; De la Rosa Herrero, Marcela

    2000-01-01

    La meta-heurística ACO (Ant Colony Optimization) es un procedimiento heurístico para la resolución de problemas de optimización discreta basado en el comportamiento de las hormigas. Sus principales características son: (1) la utilización de

  20. Hybridisations Of Simulated Annealing And Modified Simplex Algorithms On A Path Of Steepest Ascent With Multi-Response For Optimal Parameter Settings Of ACO

    Science.gov (United States)

    Luangpaiboon, P.

    2009-10-01

    Many entrepreneurs face to extreme conditions for instances; costs, quality, sales and services. Moreover, technology has always been intertwined with our demands. Then almost manufacturers or assembling lines adopt it and come out with more complicated process inevitably. At this stage, products and service improvement need to be shifted from competitors with sustainability. So, a simulated process optimisation is an alternative way for solving huge and complex problems. Metaheuristics are sequential processes that perform exploration and exploitation in the solution space aiming to efficiently find near optimal solutions with natural intelligence as a source of inspiration. One of the most well-known metaheuristics is called Ant Colony Optimisation, ACO. This paper is conducted to give an aid in complicatedness of using ACO in terms of its parameters: number of iterations, ants and moves. Proper levels of these parameters are analysed on eight noisy continuous non-linear continuous response surfaces. Considering the solution space in a specified region, some surfaces contain global optimum and multiple local optimums and some are with a curved ridge. ACO parameters are determined through hybridisations of Modified Simplex and Simulated Annealing methods on the path of Steepest Ascent, SAM. SAM was introduced to recommend preferable levels of ACO parameters via statistically significant regression analysis and Taguchi's signal to noise ratio. Other performance achievements include minimax and mean squared error measures. A series of computational experiments using each algorithm were conducted. Experimental results were analysed in terms of mean, design points and best so far solutions. It was found that results obtained from a hybridisation with stochastic procedures of Simulated Annealing method were better than that using Modified Simplex algorithm. However, the average execution time of experimental runs and number of design points using hybridisations were

  1. Certeza diagnóstica en la mortalidad de una población de pacientes con trasplante cardíaco

    Directory of Open Access Journals (Sweden)

    Marcos Amuchástegui

    2008-01-01

    Full Text Available RESUMENIntroducciónA pesar de que la morbimortalidad en el trasplante cardíaco ha sido motivo de extensoanálisis, la mayoría de los estudios y registros de mortalidad en pacientes trasplantados sebasan sobre datos clínicos. En la bibliografía existen comunicaciones aisladas de autopsiasen pacientes con trasplante cardíaco.ObjetivoDeterminar la importancia de la realización de estudios anatomopatológicos para el diagnósticode causa de muerte en un programa de trasplante cardíaco.Material y métodosSe incluyeron todos los pacientes con trasplante cardíaco fallecidos entre enero 1990 y enero2005. El diagnóstico definitivo de la causa de muerte fue corroborado por autopsia obiopsia de órgano sólido. Las causas de muerte evaluadas fueron falla precoz del injerto,rechazo celular, infección, enfermedad vascular del injerto, neoplasia y otros.ResultadosDurante el período en estudio 73 pacientes fueron sometidos a trasplante cardíaco; de ellos,fallecieron 31. Se obtuvieron 12 autopsias y 7 biopsias de órgano sólido que certificaron lacausa de muerte (61%. La causa de muerte más frecuente fue el rechazo celular mayor degrado III. En el 12,9%, la anatomía patológica difirió de la sospecha clínica de la causa demuerte.ConclusiónLa información clinicopatológica derivada de estudios post mortem es un indicador de nuestrarealidad asistencial y se constituye en un pilar fundamental para el conocimiento y elmanejo futuro de los pacientes trasplantados, por lo que consideramos que la realización deautopsias en estos pacientes es de vital importancia.REV ARGENT CARDIOL 2008;76:292-294.

  2. Certeza diagnóstica en la mortalidad de una población de pacientes con trasplante cardíaco

    Directory of Open Access Journals (Sweden)

    Marcos Amuchástegui (h,

    2006-01-01

    Full Text Available Introducción A pesar de que la morbimortalidad en el trasplante cardíaco ha sido motivo de extenso análisis, la mayoría de los estudios y registros de mortalidad en pacientes trasplantados se basan sobre datos clínicos. En la bibliografía existen comunicaciones aisladas de autopsias en pacientes con trasplante cardíaco.Objetivo Determinar la importancia de la realización de estudios anatomopatológicos para el diagnóstico de causa de muerte en un programa de trasplante cardíaco.Material y métodosSe incluyeron todos los pacientes con trasplante cardíaco fallecidos entre enero 1990 y enero 2005. El diagnóstico definitivo de la causa de muerte fue corroborado por autopsia o biopsia de órgano sólido. Las causas de muerte evaluadas fueron falla precoz del injerto, rechazo celular, infección, enfermedad vascular del injerto, neoplasia y otros.ResultadosDurante el período en estudio 73 pacientes fueron sometidos a trasplante cardíaco; de ellos, fallecieron 31. Se obtuvieron 12 autopsias y 7 biopsias de órgano sólido que certificaron la causa de muerte (61%. La causa de muerte más frecuente fue el rechazo celular mayor de grado III. En el 12,9%, la anatomía patológica difirió de la sospecha clínica de la causa de muerte.ConclusiónLa información clinicopatológica derivada de estudios post mortem es un indicador de nuestra realidad asistencial y se constituye en un pilar fundamental para el conocimiento y el manejo futuro de los pacientes trasplantados, por lo que consideramos que la realización de autopsias en estos pacientes es de vital importancia.

  3. Infra-population and -community dynamics of the parasites Nosema apis and Nosema ceranae, and consequences for honey bee (Apis mellifera hosts.

    Directory of Open Access Journals (Sweden)

    Geoffrey R Williams

    Full Text Available Nosema spp. fungal gut parasites are among myriad possible explanations for contemporary increased mortality of western honey bees (Apis mellifera, hereafter honey bee in many regions of the world. Invasive Nosema ceranae is particularly worrisome because some evidence suggests it has greater virulence than its congener N. apis. N. ceranae appears to have recently switched hosts from Asian honey bees (Apis cerana and now has a nearly global distribution in honey bees, apparently displacing N. apis. We examined parasite reproduction and effects of N. apis, N. ceranae, and mixed Nosema infections on honey bee hosts in laboratory experiments. Both infection intensity and honey bee mortality were significantly greater for N. ceranae than for N. apis or mixed infections; mixed infection resulted in mortality similar to N. apis parasitism and reduced spore intensity, possibly due to inter-specific competition. This is the first long-term laboratory study to demonstrate lethal consequences of N. apis and N. ceranae and mixed Nosema parasitism in honey bees, and suggests that differences in reproduction and intra-host competition may explain apparent heterogeneous exclusion of the historic parasite by the invasive species.

  4. A Time Trade-off-derived Value Set of the EQ-5D-5L for Canada

    Science.gov (United States)

    Pullenayegum, Eleanor; Gaebel, Kathy; Bansback, Nick; Bryan, Stirling; Ohinmaa, Arto; Poissant, Lise; Johnson, Jeffrey A.

    2016-01-01

    Background: The 5-level version of the EQ-5D (EQ-5D-5L) was recently developed. A number of preference-based scoring systems are being developed for several countries around the world. Objective: To develop a value set for the EQ-5D-5L based on societal preferences in Canada. Methods: We used age, sex, and education quota sampling from the general population from 4 cities across Canada. Composite time trade-off (cTTO) and traditional time trade-off (tTTO) were used as the main elicitation technique. A total of 86 EQ-5D-5L health states grouped into 10 blocks were valued using cTTO, whereas a subset of 18 severe states was also valued using tTTO. Participants meeting predefined inconsistency criteria were excluded from the analyses. For the value set development, we used tTTO and positive cTTO values, while censoring negative and zero cTTO values at zero. Models with the main effects presented using linear terms combined with various additional terms were estimated. The preferred model was selected based primarily on logically ordered coefficients, and secondly model fit. Results: Of the 1209 participants who completed the interview, 136 met criteria that excluded them from the primary analyses. The demographics and socioeconomic status of the remaining 1073 participants were similar to the Canadian general population. The preferred model has 5 linear terms for the main effects, a term for level 4 or 5 for each dimension, and a term for the squared total number of level 4 or 5 beyond the first. For this preferred model, the health utilities ranged from −0.148 for the worst (55555) to 0.949 for the best (11111) EQ-5D-5L states. Conclusions: This is the first TTO-based value set of the EQ-5D-5L for Canada. It can be used to support the health utility estimation in economic evaluations for reimbursement decision making in Canada. PMID:26492214

  5. “Wrapping” X3DOM around Web Audio API

    Directory of Open Access Journals (Sweden)

    Andreas Stamoulias

    2015-12-01

    Full Text Available Spatial sound has a conceptual role in the Web3D environments, due to highly realism scenes that can provide. Lately the efforts are concentrated on the extension of the X3D/ X3DOM through spatial sound attributes. This paper presents a novel method for the introduction of spatial sound components in the X3DOM framework, based on X3D specification and Web Audio API. The proposed method incorporates the introduction of enhanced sound nodes for X3DOM which are derived by the implementation of the X3D standard components, enriched with accessional features of Web Audio API. Moreover, several examples-scenarios developed for the evaluation of our approach. The implemented examples established the achievability of new registered nodes in X3DOM, for spatial sound characteristics in Web3D virtual worlds.

  6. Draft genome sequence of the Algerian bee Apis mellifera intermissa.

    Science.gov (United States)

    Haddad, Nizar Jamal; Loucif-Ayad, Wahida; Adjlane, Noureddine; Saini, Deepti; Manchiganti, Rushiraj; Krishnamurthy, Venkatesh; AlShagoor, Banan; Batainh, Ahmed Mahmud; Mugasimangalam, Raja

    2015-06-01

    Apis mellifera intermissa is the native honeybee subspecies of Algeria. A. m. intermissa occurs in Tunisia, Algeria and Morocco, between the Atlas and the Mediterranean and Atlantic coasts. This bee is very important due to its high ability to adapt to great variations in climatic conditions and due to its preferable cleaning behavior. Here we report the draft genome sequence of this honey bee, its Whole Genome Shotgun project has been deposited at DDBJ/EMBL/GenBank under the accession JSUV00000000. The 240-Mb genome is being annotated and analyzed. Comparison with the genome of other Apis mellifera sub-species promises to yield insights into the evolution of adaptations to high temperature and resistance to Varroa parasite infestation. PMID:26484171

  7. Draft genome sequence of the Algerian bee Apis mellifera intermissa

    Directory of Open Access Journals (Sweden)

    Nizar Jamal Haddad

    2015-06-01

    Full Text Available Apis mellifera intermissa is the native honeybee subspecies of Algeria. A. m. intermissa occurs in Tunisia, Algeria and Morocco, between the Atlas and the Mediterranean and Atlantic coasts. This bee is very important due to its high ability to adapt to great variations in climatic conditions and due to its preferable cleaning behavior. Here we report the draft genome sequence of this honey bee, its Whole Genome Shotgun project has been deposited at DDBJ/EMBL/GenBank under the accession JSUV00000000. The 240-Mb genome is being annotated and analyzed. Comparison with the genome of other Apis mellifera sub-species promises to yield insights into the evolution of adaptations to high temperature and resistance to Varroa parasite infestation.

  8. Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups

    DEFF Research Database (Denmark)

    Janssen, M F; Pickard, A Simon; Golicki, Dominik;

    2012-01-01

    PURPOSE: The aim of this study was to assess the measurement properties of the 5-level classification system of the EQ-5D (5L), in comparison with the 3-level EQ-5D (3L). METHODS: Participants (n = 3,919) from six countries, including eight patient groups with chronic conditions (cardiovascular......), redistribution properties, ceiling, discriminatory power, convergent validity, and known-groups validity. RESULTS: Missing values were on average 0.8 % for 5L and 1.3 % for 3L. In total, 2.9 % of responses were inconsistent between 5L and 3L. Redistribution from 3L to 5L using EQ dimension-specific rating scales...... as reference was validated for all 35 3L-5L-level combinations. For 5L, 683 unique health states were observed versus 124 for 3L. The ceiling was reduced from 20.2 % (3L) to 16.0 % (5L). Absolute discriminatory power (Shannon index) improved considerably with 5L (mean 1.87 for 5L versus 1.24 for 3L...

  9. Antibacterial Activity of a Cardanol from Thai Apis mellifera Propolis

    OpenAIRE

    Boonsai, Pattaraporn; Phuwapraisirisan, Preecha; Chanchao, Chanpen

    2014-01-01

    Background: Propolis is a sticky, dark brown resinous residue made by bees that is derived from plant resins. It is used to construct and repair the nest, and in addition possesses several diverse bioactivities. Here, propolis from Apis mellifera from Nan province, Thailand, was tested for antibacterial activity against Gram+ve (Staphylococcus aureus and Paenibacillus larvae) and Gram-ve (Escherichia coli) bacteria. Materials and methods: The three bacterial isolates were confirmed for specie...

  10. Paternity skew in seven species of honeybees (Hymenoptera: Apidae: Apis)

    OpenAIRE

    Schlüns, Helge; F.A. MORITZ, Robin; Michael G. Lattorff, H.; Koeniger, Gudrun

    2005-01-01

    International audience Honeybees (Apis) show an extremely polyandrous mating system. In general honeybee queens mate with at least ten drones. The reproductive success of the drones is usually biased giving rise to speculations of a first or last male advantage. Especially for A. andreniformis and A. florea a first male advantage was hypothesized due to the peculiar anatomy of their male genitalia. We reanalyzed data from the literature by using a sample size calibration method to survey t...

  11. Analisis Finansial Dan Pemasaran Usaha Lebah Madu (Apis mellifera)

    OpenAIRE

    Agustini, Rini

    2012-01-01

    This research aims to determine the financial analysis and marketing margins beekeeping businesses (Apis mellifera) in the village of Samura, Subdistrict Gung Negri, District Kabanjahe, Karo. The analysis method used was descriptive analysis and financial analysis with multiple criteria: Net Present Value (NPV), Benefit Cost Ratio (BCR) and Internal Rate of Returns (IRR). The results showed the beekeeping business have value NPV, BCR, and IRR indicating that the beekeeping business worth ...

  12. Genetic characterization of a polymorphic dipeptidyl aminopeptidase of Apis mellifera

    OpenAIRE

    Marco Antonio Del Lama,; Boraschi, Daniele; Ademilson Espencer Egea Soares,; Duran, Ximena

    2004-01-01

    International audience Dipeptidyl aminopeptidase (DAP) activity towards L-leucylglycine-$\\beta$-naphthylamide (Leu-Gly NA) was characterized in pupae and adult extracts of Apis mellifera. Enzyme activity was more conspicuous in pupae than in adult extracts and it seemed to be concentrated in digestive tract tissues. Two genetically determined electrophoretic variants were observed in honeybee samples from the USA and Chile; in Brazilian Africanized bees, two additional variants were observ...

  13. Reevaluation of honeybee (Apis mellifera) microtaxonomy: a geometric morphometric approach

    OpenAIRE

    Kandemir, Irfan; Özkan, Ayça; FUCHS, Stefan

    2011-01-01

    International audience In the present study, the microtaxonomy of honeybee (Apis mellifera L.) subspecies was reevaluated based on a geometric morphometric method. Wing images of honeybee subspecies, obtained from the Morphometric Bee Data Bank in Oberursel, Germany, were assigned to four honeybee lineages from the indivudial images, and 40 Cartesian coordinates were obtained. Honeybee lineages were significantly different based on individual and colony consensus average wing shapes of hon...

  14. Using open web APIs in teaching web mining

    OpenAIRE

    Chau, M; H Chen; Li, X; Ho, YJ; Tseng, C

    2009-01-01

    With the advent of the World Wide Web, many business applications that utilize data mining and text mining techniques to extract useful business information on the Web have evolved from Web searching to Web mining. It is important for students to acquire knowledge and hands-on experience in Web mining during their education in information systems curricula. This paper reports on an experience using open Web Application Programming Interfaces (APIs) that have been made available by major Inter...

  15. Metadata and API Based Environment Aware Content Delivery Architecture

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    One of the limitations of current content delivery networks is lack of support for environment aware content delivery. This paper first discusses the requirements of such support, and proposes a new metadata gateway based environment aware content delivery architecture. The paper discusses in some details key functions and technologies of environment aware content delivery architecture, including its APIs and control policies. Finally the paper presents an application to illustrate advantages of environment aware content delivery architecture in the context of next generation network.

  16. ADS 2.0: New Architecture, API and Services

    Science.gov (United States)

    Chyla, R.; Accomazzi, A.; Holachek, A.; Grant, C. S.; Elliott, J.; Henneken, E. A.; Thompson, D. M.; Kurtz, M. J.; Murray, S. S.; Sudilovsky, V.

    2015-09-01

    The ADS platform is undergoing the biggest rewrite of its 20-year history. While several components have been added to its architecture over the past couple of years, this talk will concentrate on the underpinnings of ADS's search layer and its API. To illustrate the design of the components in the new system, we will show how the new ADS user interface is built exclusively on top of the API using RESTful web services. Taking one step further, we will discuss how we plan to expose the treasure trove of information hosted by ADS (10 million records and fulltext for much of the Astronomy and Physics refereed literature) to partners interested in using this API. This will provide you (and your intelligent applications) with access to ADS's underlying data to enable the extraction of new knowledge and the ingestion of these results back into the ADS. Using this framework, researchers could run controlled experiments with content extraction, machine learning, natural language processing, etc. In this talk, we will discuss what is already implemented, what will be available soon, and where we are going next.

  17. Variation morphogeometrics of Africanized honey bees (Apis mellifera in Brazil

    Directory of Open Access Journals (Sweden)

    Lorena A. Nunes

    2012-09-01

    Full Text Available The morphometrics of the honey bee Apis mellifera L., 1758 has been widely studied mainly because this species has great ecological importance, high adaptation capacity, wide distribution and capacity to effectively adapt to different regions. The current study aimed to investigate the morphometric variations of wings and pollen baskets of honey bees Apis mellifera scutellata Lepeletier, 1836 from the five regions in Brazil. We used geometric morphometrics to identify the existence of patterns of variations of shape and size in Africanized honey bees in Brazil 16 years after the classic study with this species, allowing a temporal and spatial comparative analysis using new technological resources to assess morphometrical data. Samples were collected in 14 locations in Brazil, covering the five geographical regions of the country. The shape analysis and multivariate analyses of the wing allowed to observe that there is a geographical pattern among the population of Apis mellifera in Brazil. The geographical variations may be attributed to the large territorial extension of the country in addition to the differences between the bioregions.

  18. A SNP based high-density linkage map of Apis cerana reveals a high recombination rate similar to Apis mellifera.

    Directory of Open Access Journals (Sweden)

    Yuan Yuan Shi

    Full Text Available BACKGROUND: The Eastern honey bee, Apis cerana Fabricius, is distributed in southern and eastern Asia, from India and China to Korea and Japan and southeast to the Moluccas. This species is also widely kept for honey production besides Apis mellifera. Apis cerana is also a model organism for studying social behavior, caste determination, mating biology, sexual selection, and host-parasite interactions. Few resources are available for molecular research in this species, and a linkage map was never constructed. A linkage map is a prerequisite for quantitative trait loci mapping and for analyzing genome structure. We used the Chinese honey bee, Apis cerana cerana to construct the first linkage map in the Eastern honey bee. RESULTS: F2 workers (N = 103 were genotyped for 126,990 single nucleotide polymorphisms (SNPs. After filtering low quality and those not passing the Mendel test, we obtained 3,000 SNPs, 1,535 of these were informative and used to construct a linkage map. The preliminary map contains 19 linkage groups, we then mapped the 19 linkage groups to 16 chromosomes by comparing the markers to the genome of A. mellfiera. The final map contains 16 linkage groups with a total of 1,535 markers. The total genetic distance is 3,942.7 centimorgans (cM with the largest linkage group (180 loci measuring 574.5 cM. Average marker interval for all markers across the 16 linkage groups is 2.6 cM. CONCLUSION: We constructed a high density linkage map for A. c. cerana with 1,535 markers. Because the map is based on SNP markers, it will enable easier and faster genotyping assays than randomly amplified polymorphic DNA or microsatellite based maps used in A. mellifera.

  19. Aggressiveness index of Apis Mellifera (Hymenoptera: Aapidae) Índice de agresividad en Apis mellifera ( Hymenoptera: Aapidae )

    OpenAIRE

    Sierra Omar Danilo; Insuasty Torres Jennyfer

    2004-01-01

    An index measuring the aggressiveness among ten colonies of Apis mellifera was elaborated based on the third generation synthetic indices by Charum et al. (1999). The index values are subject to a fixed parameter used as the beginning or standard value, and correspond to the aggressive features of some Africans colonies studied by Rothenbuler et al. (1968). In the ten colonies the index values are notably smaller than those of African colonies and are biased to the lowest values. This indicat...

  20. Evaluation of API microtube GT system for detection of germ tube production by clinically significant yeasts.

    OpenAIRE

    Philip, A; Tsui, A; O'Brien, J E

    1983-01-01

    A total of 152 fresh consecutive yeast isolates were tested for their ability to produce germ tubes by the API GT system (Analytab products, Plainview, N.Y.) and by a conventional method. The API system was found to be less sensitive than the conventional method. The costs per test by the API system and the conventional method were $0.76 and $0.39, respectively.

  1. R404A/CO_2复叠式制冷系统的熵分析%Entropy Analysis of R404A/CO_2 Cascade Refrigeration System

    Institute of Scientific and Technical Information of China (English)

    赖艳华; 王庆为; 吕明新; 董震; 潘继红

    2012-01-01

    为了研究R404A/CO_2复叠式制冷系统的性能,对其进行了热力学分析。采用理论计算和熵产最小法分析蒸发温度T_e、冷凝温度T_k、冷凝蒸发器的传热温差△T等参数对该系统的性能、部件及整个系统的熵产的影响。结果表明,给定T_e、T_k和△T时,在最佳低温级冷凝温度下,系统COP取得最大值,系统总熵产取得最小值;高温级节流阀和压缩机、冷凝蒸发器和低温级压缩机的熵产约占总熵产的80%。%In order to study the performance of R404A/CO_2 cascade refrigeration system,thermodynamic analysis is applied to this system.Theoretical calculation and entropy generation minimization method were adopted to get the influence of some important operating and design parameters on the performance of the system and entropy generations of each component and the whole system,such as the evaporating temperature T_e,the condensing temperature T_k and the temperature difference AT in the cascade-condenser.The results indicate that there are a maximum coefficient of performance and a minimum total entropy generation of the system at the optimal condensing temperature of the cascade-condenser when T_e,T_k and△T are constant.The total entropy generations of the throttling device and the compressor of the R404A circuit,the cascade-condenser and the compressor of CO_2 circuit are 80%of the total entropy generation of the whole system.

  2. Achados oftalmológicos em pacientes que receberam transplante cardíaco Ophthalmologic findings in cardiac transplant recipients

    Directory of Open Access Journals (Sweden)

    Cecília Sales Pires

    2007-10-01

    Full Text Available OBJETIVO: Avaliar os achados oculares, pelo exame oftalmológico, em indivíduos que receberam transplante cardíaco, buscando especialmente investigar possíveis alterações na camada de fibras nervosas da retina com polarímetro de varredura a laser. MÉTODOS: Foram estudados 15 indivíduos que receberam transplante cardíaco no período de setembro de 2003 a julho de 2004. Todos foram submetidos a exame que constava de acuidade visual para longe (AVL, biomicroscopia, tonometria e fundoscopia. Onze pacientes foram submetidos ao analisador de fibras nervosas GDx. Doze eram do sexo masculino e a média da idade foi de 55,0 ± 13,5 anos. O tempo decorrido desde o transplante variou de 3 a 74 meses, com média de 29,7 ± 20,8 meses. RESULTADOS: A AVL com melhor correção foi igual ou melhor do que 20/40 em todos os pacientes. Em um deles observou-se a presença de catarata subcapsular posterior; em outro, nubéculas na córnea secundárias a quadro de herpes zoster. À fundoscopia pôde-se observar lesão cicatrizada sugestiva de retinocoroidite em um paciente. As alterações observadas à biomicroscopia e à fundoscopia eram esperadas devido à imunossupressão subseqüente ao transplante. Ao GDx observou-se perda de fibras da camada de fibras nervosas da retina superior em 12 dos 22 olhos avaliados. CONCLUSÃO: Os resultados apóiam a suposição de que antes ou durante o transplante cardíaco tenha havido diminuição no aporte de oxigênio à circulação retiniana, levando a perda parcial de fibras da retina.PURPOSE: To evaluate findings of ophthalmologic examinations in cardiac transplant recipients, searching especially for changes in the retinal nerve fiber layer by means of Scanning Laser Polarimetry. METHODS: Fifteen cardiac transplant recipients were examined from September 2003 to July 2004. All of them underwent ophthalmologic examination, which consisted of visual acuity (VA, biomicroscopy, tonometry and fundoscopy. Fiber layer

  3. EQ-5D-5L in the General German Population: Comparison and Evaluation of Three Yearly Cross-Section Surveys.

    Science.gov (United States)

    Huber, Manuel B; Reitmeir, Peter; Vogelmann, Martin; Leidl, Reiner

    2016-03-21

    Health-related quality of life (HRQoL) is a key measure for evaluating health status in populations. Using the recent EQ-5D-5L for measurement, this study analyzed quality of life results and their stability over consecutive population surveys. Three cross-section surveys for representative samples of the general German population from 2012, 2013, and 2014 were evaluated using the EQ-5D-5L descriptive system and valuation by the Visual Analog Scale (VAS). Aggregated sample size reached 6074. The dimension with the highest prevalence of problems was pain/discomfort (31.7%). Compared with 2012 (59.3%), the percentage of participants in the best health state increased slightly in 2013 (63.4%) and 2014 (62%). Over the 3-year period, diabetes and heart disease had the strongest negative influence on mean VAS result. The number of reported chronic diseases cumulatively reduced mean VAS. Extreme problems in one or more dimensions were stated by only 0.1%-0.2% of patients. Of the potential 247 health states with a problem score ≥ 20, only six were observed in the aggregated sample. HRQoL results were fairly stable over the 3 years, but the share of the population with no problems was not. Results from the aggregated sample may serve as updated reference values for the general German population.

  4. EQ-5D-5L in the General German Population: Comparison and Evaluation of Three Yearly Cross-Section Surveys

    Directory of Open Access Journals (Sweden)

    Manuel B. Huber

    2016-03-01

    Full Text Available Health-related quality of life (HRQoL is a key measure for evaluating health status in populations. Using the recent EQ-5D-5L for measurement, this study analyzed quality of life results and their stability over consecutive population surveys. Three cross-section surveys for representative samples of the general German population from 2012, 2013, and 2014 were evaluated using the EQ-5D-5L descriptive system and valuation by the Visual Analog Scale (VAS. Aggregated sample size reached 6074. The dimension with the highest prevalence of problems was pain/discomfort (31.7%. Compared with 2012 (59.3%, the percentage of participants in the best health state increased slightly in 2013 (63.4% and 2014 (62%. Over the 3-year period, diabetes and heart disease had the strongest negative influence on mean VAS result. The number of reported chronic diseases cumulatively reduced mean VAS. Extreme problems in one or more dimensions were stated by only 0.1%–0.2% of patients. Of the potential 247 health states with a problem score ≥20, only six were observed in the aggregated sample. HRQoL results were fairly stable over the 3 years, but the share of the population with no problems was not. Results from the aggregated sample may serve as updated reference values for the general German population.

  5. El calcio en los miocitos cardíacos y su papel en las miocardiopatías.

    Directory of Open Access Journals (Sweden)

    Guido Ulate Montero

    2006-01-01

    Full Text Available El papel que desempeña el calcio en los miocitos cardíacos abarca un gran número de funciones, desde su rol en el acoplamiento excitación-ccontracción hasta su papel de segundo mensajero en las diversas vías de señalización, algunas de las cuales se activan en procesos que afectan la integridad del tejido miocárdico y que tienen que ver con el crecimiento y la apoptosis de los miocitos y que al final, son los que determinan la evolución de la mayoría de las cardiomiopatías. En esta revisión se abordan los mecanismos fisiológicos en las células de músculo cardíaco en los que este ión juega un papel determinante y los cambios que se presentan en ciertas cardiopatías como la miocardiopatía arritmogénica del ventrículo derecho, las miocardiopatías asociadas a alteraciones en el receptor de rianodina y la miocardiopatía dilatada. Se revisa también la farmacodinamia de los agentes inotrópicos positivos que actúan sensibilizando los miofilamentos del sarcómero al calcio.The rol played by calcium in cardiomyocytes includes a great number of functions like the excitation-contraction coupling as well as a second messenger in diverse signaling pathways. Some of these pathways are activated in processes that affect the cardiac tissue integrity and also participate in cell growth and apoptosis, determining the poor prognosis that characterize the majority of the cardiomyopathies. In this review,the mechanisms inside the cardiomyocytes in which participates calcium and the pathophysiological changes observed in some cardiac diseases like arrhythmogenic right ventricular cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, idiopathic dilated cardiomyopathy, and others, are described. The action mechanism of positive inotropic drugs that act as sarcomere myofilaments sensitizers is also reviewed.

  6. Valvoplastia mitral percutânea complicada com tamponamento cardíaco em paciente gestante Percutaneous mitral valvuloplasty complicated by cardiac tamponade in a pregnant patient

    Directory of Open Access Journals (Sweden)

    Luís Seca

    2008-11-01

    Full Text Available A ocorrência de Hemopericárdio com Tamponamento Cardíaco é uma complicação da Valvoplastia Mitral Percutânea por balão (VMB, que apesar de pouco freqüente, pode ter graves conseqüências materno-fetais. Este artigo descreve o caso de um tamponamento cardíaco após VMB em uma mulher de 28 anos, com estenose mitral reumática severa na 20ª semana de gravidez.The occurrence of hemopericardium with cardiac tamponade is a complication of percutaneous balloon mitral valvuloplasty (BMV which, although uncommon, may have severe maternal and fetal consequences. This article describes a case of cardiac tamponade following BMV in a 28-year-old woman with severe rheumatic mitral stenosis in the 20th week of gestation.

  7. Acute Care of At-Risk Newborns (ACoRN: quantitative and qualitative educational evaluation of the program in a region of China

    Directory of Open Access Journals (Sweden)

    Singhal Nalini

    2012-06-01

    Full Text Available Abstract Background The Acute Care of at-Risk Newborns (ACoRN program was developed in Canada for trained health care providers for the identification and management of newborns who are at-risk and/or become unwell in the first few hours or days after birth. The ACoRN process follows an 8-step framework that enables the evaluation and management of babies irrespective of the experience or expertise of the caregiving individual or team. This study assesses the applicability of the program to Chinese pediatric practitioners. Methods Course content and educational materials were translated from English into Chinese by bilingual neonatal practitioners. Confidence and knowledge questionnaires were developed and reviewed for face and content validity by a team of ACoRN instructors. Bilingual Chinese instructors were trained at the tertiary perinatal centre in Hangzhou Zhejiang to deliver the course at 15 level II county hospitals. Participants completed pre- and post-course confidence and knowledge questionnaires and provided feedback through post-course focus groups. Results 216 physicians and nurses were trained. Confidence and knowledge relating to neonatal stabilization improved significantly following the courses. Participants rated course utility and function between 4.2 and 4.6/5 on all items. Pre/post measures of confidence were significantly correlated with post course knowledge. Focus group data supported the perceived value of the program and recommended course adjustments to include pre-course reading, and increased content related to simulation, communication skills, and management of respiratory illness and jaundice. Conclusions ACoRN, a Canadian educational program, appears to be well received by Chinese health care providers and results in improved knowledge and confidence. International program adaptation for use by health care professionals requires structured and systematic evaluation to ensure that the program meets the needs of

  8. L’intelligence collective dans un contexte de développement professionnel continu : ACoPé, l’exemple d’une communauté de pratique

    OpenAIRE

    Pichon, Aude; Morel, Alexandre; Gassie, Brigitte; Vandenkoornhuyse, Christine; Delalande, Pascaline

    2015-01-01

    Cooperating with a view to furthering professional development, taking decisions and functioning interoperatively within a community implies working with participants committed to fostering strong relationships, reflective practice, and reaching shared understanding.The collaboration between the ACoPé educational advisors takes place within this context itself part of the wider framework of a higher education environment with intersectoral, interprofessional, interdisciplinary and inter-regio...

  9. Uma breve revisão histórica do desenvolvimento da soldagem dos aços API para tubulações A brief history review of development on API steels welding for pipeline

    Directory of Open Access Journals (Sweden)

    Jaime Casanova Soeiro Junior

    2013-06-01

    Full Text Available Este trabalho enfoca o desenvolvimento dos aços API para tubulações desde o aço API 5L X42, desenvolvido em 1948, através de laminação a quente seguida de tratamento térmico. Desde então foram feitos diferentes desenvolvimentos visando aumentar a resistência mecânica e a tenacidade, além de melhorar a soldabilidade. Entre eles, a adição de elementos de liga, produzindo os aços ARBL e a utilização de rotas de processamento termomecânico durante a laminação. Inicialmente a rota utilizada era a laminação a quente controlada (TMCR, com utilização de elemento microligante como Nb para os aços X60 e o conjunto Nb e V para os aços X65 e X70, associado a uma redução do teor de carbono. Posteriormente foi implantada a rota de fabricação do aço por laminação controlada seguida de resfriamento controlado (TMCP, com redução de carbono e adição de Nb e Ti para os aços X80, e adições de Mo, Nb, Be Ti para os X100. A redução do carbono foi motivada também para melhorar a sua soldabilidade e, por este motivo, estes aços são soldados por diferentes processos de soldagem, como o eletrodo revestido. Desenvolvimentos recentes com raiz feita com MAG-TC e enchimento com arame tubular tem dado resultados animadores.This paper is a brief history on the development of pipelines steels since the API 5L X42 steel, developed in 1948 by hot rolling followed by heat treatment. Subsequently different developments were made to increase the strength and toughness of these materials, and to improve their weldability. Among them, the addition of microalloying elements, producing HSLA steels and thermomechanical processing routes during hot rolling. Initially the route used was the controlled hot rolling (TMCR, together with microalloying element such as Nb for X60 steel and Nb plus V for X65 and X70 steels, associated with a reduction in carbon content. Later, the thermomechanical controlled process (TMCP manufacturing route was

  10. Failure behaviour of preloaded API line pipe threaded connections

    OpenAIRE

    Seys, Jonas; Roeygens, Koenraad; Van Wittenberghe, Jeroen; Galle, Timothy; DE BAETS, Patrick; De Waele, Wim

    2011-01-01

    This paper reports on numerical and experimental work concerning the fatigue behaviour and sealing capacity of threaded pipe connections (1” API Line Pipe). Numerical simulations are performed using Abaqus® in combination with ThreadGen©. The fatigue life of a thick-walled standard coupling is determined using a four-point bending test. The corresponding S-N curve is compared to results of previous work on thin-walled specimens. It can be concluded that the standard thick-walled connection ha...

  11. Efectos digitales de audio con Web Audio API

    OpenAIRE

    GARCÍA CHAPARRO, SAMUEL

    2015-01-01

    El presente trabajo consiste en un estudio de la capacidad de Web Audio API para el procesado de efectos de audio en tiempo real. De todos los efectos de audio posibles se han elegido el wah-wah, el flanger y el choris, efectos ampliamente empleados con guitarra eléctrica. Se crean funciones de lenguaje JavaScript que modelan el comportamiento de los efectos de audio elegidos, haciéndolas funcionar sobre una plataforma web HTML5. García Chaparro, S. (2015). Efectos digitales de audio con W...

  12. Solar Eclipse Computer API: Planning Ahead for August 2017

    Science.gov (United States)

    Bartlett, Jennifer L.; Chizek Frouard, Malynda; Lesniak, Michael V.; Bell, Steve

    2016-01-01

    With the total solar eclipse of 2017 August 21 over the continental United States approaching, the U.S. Naval Observatory (USNO) on-line Solar Eclipse Computer can now be accessed via an application programming interface (API). This flexible interface returns local circumstances for any solar eclipse in JavaScript Object Notation (JSON) that can be incorporated into third-party Web sites or applications. For a given year, it can also return a list of solar eclipses that can be used to build a more specific request for local circumstances. Over the course of a particular eclipse as viewed from a specific site, several events may be visible: the beginning and ending of the eclipse (first and fourth contacts), the beginning and ending of totality (second and third contacts), the moment of maximum eclipse, sunrise, or sunset. For each of these events, the USNO Solar Eclipse Computer reports the time, Sun's altitude and azimuth, and the event's position and vertex angles. The computer also reports the duration of the total phase, the duration of the eclipse, the magnitude of the eclipse, and the percent of the Sun obscured for a particular eclipse site. On-line documentation for using the API-enabled Solar Eclipse Computer, including sample calls, is available (http://aa.usno.navy.mil/data/docs/api.php). The same Web page also describes how to reach the Complete Sun and Moon Data for One Day, Phases of the Moon, Day and Night Across the Earth, and Apparent Disk of a Solar System Object services using API calls.For those who prefer using a traditional data input form, local circumstances can still be requested that way at http://aa.usno.navy.mil/data/docs/SolarEclipses.php. In addition, the 2017 August 21 Solar Eclipse Resource page (http://aa.usno.navy.mil/data/docs/Eclipse2017.php) consolidates all of the USNO resources for this event, including a Google Map view of the eclipse track designed by Her Majesty's Nautical Almanac Office (HMNAO). Looking further ahead, a

  13. Entorno de Audio usando la nueva API de HTML 5

    OpenAIRE

    LATORRE PLAYÁN, JAVIER

    2015-01-01

    Este trabajo tiene como objetivo el diseño y programación de una aplicación de audio sobre la nueva API de audio de HTML 5. Para ello, utilizamos el programa SoundCool, que es propiedad de la Universidad Politécnica de Valencia y, a partir de los módulos que implementa, los adaptaremos al lenguaje antes mencionado, con el propósito de hacerlo más accesible y atractivo visualmente. Para poder llevar a cabo lo mencionado anteriormente, se ha realizado, en primer lugar, un trabajo de investig...

  14. Swarm Intelligence Based Ant Colony Optimization (ACO Approach for Maximizing the Lifetime of Heterogeneous Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    LingaRaj.K

    2013-11-01

    Full Text Available This paper attempts to undertake the study of maximizing the lifetime of Heterogeneous wireless sensor networks (WSNs. In wireless sensor networks, sensor nodes are typically power-constrained with limited lifetime, and thus it is necessary to know how long the network sustains its networking operations. Heterogeneous WSNs consists of different sensor devices with different capabilities. We can enhance the quality of monitoring in wireless sensor networks by increasing the coverage area. One of major issue in WSNs is finding maximum number of connected coverage. This paper proposed a Swarm Intelligence, Ant Colony Optimization (ACO based approach. Ant colony optimization algorithm provides a natural and intrinsic way of exploration of search space of coverage area. Ants communicate with their nest- mates using chemical scents known as pheromones, Based on Pheromone trail between sensor devices the shortest path is found. The methodology is based on finding the maximum number of connected covers that satisfy both sensing coverage and network connectivity. By finding the coverage area and sensing range, the network lifetime maximized and reduces the energy consumption

  15. The Norma Cluster (ACO 3627): I. A Dynamical Analysis of the Most Massive Cluster in the Great Attractor

    CERN Document Server

    Woudt, P A; Lucey, J; Fairall, A P; Moore, S A W

    2007-01-01

    A detailed dynamical analysis of the nearby rich Norma cluster (ACO 3627) is presented. From radial velocities of 296 cluster members, we find a mean velocity of 4871 +/- 54 km/s and a velocity dispersion of 925 km/s. The mean velocity of the E/S0 population (4979 +/- 85 km/s) is offset with respect to that of the S/Irr population (4812 +/- 70 km/s) by `Delta' v = 164 km/s in the cluster rest frame. This offset increases towards the core of the cluster. The E/S0 population is free of any detectable substructure and appears relaxed. Its shape is clearly elongated with a position angle that is aligned along the dominant large-scale structures in this region, the so-called Norma wall. The central cD galaxy has a very large peculiar velocity of 561 km/s which is most probably related to an ongoing merger at the core of the cluster. The spiral/irregular galaxies reveal a large amount of substructure; two dynamically distinct subgroups within the overall spiral-population have been identified, located along the Nor...

  16. Long-term storage of Ascosphaera aggregata and Ascosphaera apis, pathogens of the leafcutting bee (Megachile rotundata) and the honey bee (Apis mellifera).

    Science.gov (United States)

    Jensen, A B; James, R R; Eilenberg, J

    2009-06-01

    Survival rates of Ascosphaera aggregata and Ascosphaera apis over the course of a year were tested using different storage treatments. For spores, the storage methods tested were freeze-drying and ultra-low temperatures, and for hyphae, freeze-drying, agar slants, and two methods of ultra-low temperatures. Spores of A. aggregata and A. apis stored well at -80 degrees C and after freeze-drying. A. aggregata hyphae did not store well under any of the methods tested while A. apis hyphae survived well using cryopreservation. Spores produced from cryopreserved A. apis hyphae were infective. Long-term storage of these two important fungal bee diseases is thus possible. PMID:19332075

  17. Functional characterization of naturally occurring melittin peptide isoforms in two honey bee species, Apis mellifera and Apis cerana.

    Science.gov (United States)

    Park, Doori; Jung, Je Won; Lee, Mi Ok; Lee, Si Young; Kim, Boyun; Jin, Hye Jun; Kim, Jiyoung; Ahn, Young-Joon; Lee, Ki Won; Song, Yong Sang; Hong, Seunghun; Womack, James E; Kwon, Hyung Wook

    2014-03-01

    Insect-derived antimicrobial peptides (AMPs) have diverse effects on antimicrobial properties and pharmacological activities such as anti-inflammation and anticancer properties. Naturally occurring genetic polymorphism have a direct and/or indirect influence on pharmacological effect of AMPs, therefore information on single nucleotide polymorphism (SNP) occurring in natural AMPs provides an important clue to therapeutic applications. Here we identified nucleotide polymorphisms in melittin gene of honey bee populations, which is one of the potent AMP in bee venoms. We found that the novel SNP of melittin gene exists in these two honey bee species, Apis mellifera and Apis cerana. Nine polymorphisms were identified within the coding region of the melittin gene, of which one polymorphism that resulted in serine (Ser) to asparagine (Asp) substitution that can potentially effect on biological activities of melittin peptide. Serine-substituted melittin (Mel-S) showed more cytotoxic effect than asparagine-substituted melittin (Mel-N) against E. coli. Also, Mel-N and Mel-S had different inhibitory effects on the production of inflammatory factors such as IL-6 and TNF-α in BV-2 cells. Moreover, Mel-S showed stronger cytotoxic activities than Mel-N peptide against two human ovarian cancer cell lines. Using carbon nanotube-based transistor, we here characterized that Mel-S interacted with small unilamellar liposomes more strongly than Mel-N. Taken together, our present study demonstrates that there exist different characteristics of the gene frequency and the biological activities of the melittin peptide in two honey bee species, Apis mellifera and A. cerana. PMID:24512991

  18. Improvements and extensions to API 618 related to pulsation and mechanical response studies

    NARCIS (Netherlands)

    Eijk, A.; Smeulers, J.P.M.; Blodgett, L.E.; Smalley, A.J.

    1999-01-01

    Purchasers of reciprocating compressors need a standard to help ensure reliable installations. The PNEUROP standard evolved in Europe, and the API 618 Standard in the U.S.A. Frequent application and generally good experience, worldwide, have led to four releases of API 618, the last dated June 1995.

  19. Macelignan inhibits bee pathogenic fungi Ascophaera apis growth through HOG1 pathway

    Directory of Open Access Journals (Sweden)

    Y.K. Shin

    2016-01-01

    Full Text Available Ascosphaera apis is a bee pathogen that causes bee larvae infection disease, to which treatment is not yet well investigated. The aim of this study was to investigate antifungal susceptibility in vitro against A. apis and to identify a new antifungal agent for this pathogen through minimal inhibitory concentration (MIC assay and western blot analysis. Macelignan had 1.56 and 3.125 μg/mL MIC against A. apis after 24 and 48 h, respectively, exhibiting the strongest growth inhibition against A. apis among the tested compounds (corosolic acid, dehydrocostus lactone, loganic acid, tracheloside, fangchinoline and emodin-8-O-β-D-glucopyranoside. Furthermore, macelignan showed a narrow-ranged spectrum against various fungal strains without any mammalian cell cytotoxicity. In spite of miconazole having powerful broad-ranged anti-fungal activity including A. apis, it demonstrated strong cytotoxicity. Therefore, even if macelignan alone was effective as an antifungal agent to treat A. apis, combined treatment with miconazole was more useful to overcome toxicity, drug resistance occurrence and cost effectiveness. Finally, HOG1 was revealed as a target molecule of macelignan in the anti-A. apis activity by inhibiting phosphorylation using S. cerevisiae as a model system. Based on our results, macelignan, a food-grade antimicrobial compound, would be an effective antifungal agent against A. apis infection in bees.

  20. Differential gene expression of the honey bee Apis mellifera associated with Varroa destructor infection.

    Science.gov (United States)

    The parasitic mite, Varroa destructor, is the most serious pest of the western honey bee, Apis mellifera, and has caused the death of millions of colonies worldwide. We investigated whether Varroa infestation induces changes in Apis mellifera gene expression, and whether there are genotypic differen...

  1. LIVE L4 and LIVE L5L experiments on melt pool and crust behaviour in the RPV lower head

    International Nuclear Information System (INIS)

    LIVE-L4 and LIVE-L5L experiments investigated thermal hydraulic behavior of corium pool in the RPV lower head with a 3D test vessel LIVE. The simulant material is 80%-20% KNO3- NaNO3. Transient and steady-state parameters such as melt temperature, heat flux distribution through the vessel wall as well as crust formation characteristics were obtained. The two tests demonstrated that transient events like melt relocation and change of decay power facilitate crust deformation and change of crust thickness. The dimensionless melt temperature and heat flux through wall during the steady state can be well described independent of power density. However the dimensionless melt temperature and heat flux are dependent on the pool height. A low pool has stronger focusing effect at the upper surface than in a high pool. (author)

  2. Qualidade de vida de pacientes submetidos ao transplante cardíaco: aplicação da escala Whoqol-Bref

    Directory of Open Access Journals (Sweden)

    Maria Isis Freire de Aguiar

    2011-01-01

    Full Text Available FUNDAMENTO: O sucesso do transplante cardíaco significa garantir a sobrevida dos pacientes com cardiopatia e permitir-lhes desenvolver suas atividades diárias. O transplante cardíaco apresenta-se como a primeira opção de tratamento na falência cardíaca, representando um aumento de sobrevida e qualidade de vida dos transplantados. OBJETIVO: Avaliar a qualidade de vida de pacientes submetidos ao transplante cardíaco através da aplicação de uma escala padronizada (Whoqol-Bref. MÉTODOS: Estudo exploratório descritivo de abordagem quantitativa, realizado com 55 pacientes submetidos ao transplante cardíaco, em um período entre o terceiro e o 103º mês, que realizam acompanhamento na Unidade de Transplante e Insuficiência Cardíaca em um Hospital de Referência em Cardiologia na cidade de Fortaleza, CE. Os dados foram coletados no período de fevereiro a abril de 2009, por meio da aplicação de um questionário padronizado pela Organização Mundial da Saúde e utilização de dados constantes nos prontuários. RESULTADOS: Com relação ao domínio físico, 62,8% e 58,3% dos pacientes, dos sexos masculino e feminino, respectivamente, estão satisfeitos. No domínio psicológico, dentre pacientes do sexo masculino, 65,1% apresentam satisfação quanto à qualidade de vida e, no sexo feminino, 58,3% encontram-se satisfeitas. No domínio das relações sociais, observou-se que, no sexo masculino, 53,5% estão muito satisfeitos, e apresentou-se um nível de satisfação de 100% no sexo feminino. No domínio do meio ambiente, 65,1% do sexo masculino encontram-se satisfeitos, e no sexo feminino, 83,3% estão satisfeitas. CONCLUSÃO: O transplante cardíaco teve bastante influência na qualidade de vida dos pacientes transplantados, pois os resultados mostram-se estatisticamente significantes no pós-transplante.

  3. Individual Variability of Nosema ceranae Infections in Apis mellifera Colonies

    Directory of Open Access Journals (Sweden)

    Richard D. Fell

    2012-11-01

    Full Text Available Since 2006, beekeepers have reported increased losses of Apis mellifera colonies, and one factor that has been potentially implicated in these losses is the microsporidian Nosema ceranae. Since N. ceranae is a fairly recently discovered parasite, there is little knowledge of the variation in infection levels among individual workers within a colony. In this study we examined the levels of infection in individual bees from five colonies over three seasons using both spore counting and quantitative real-time PCR. The results show considerable intra-colony variation in infection intensity among individual workers with a higher percentage of low-level infections detected by PCR than by spore counting. Colonies generally had the highest percentage of infected bees in early summer (June and the lowest levels in the fall (September. Nosema apis was detected in only 16/705 bees (2.3% and always as a low-level co-infection with N. ceranae. The results also indicate that intra-colony variation in infection levels could influence the accuracy of Nosema diagnosis.

  4. Physicochemical analysis of apis dorsata honey from terai forests, Nepal

    International Nuclear Information System (INIS)

    The multi floral honey produced by Apis dorsata from Shahabgunj, Dhakeri, Narayanpur and Perari forest, Nepal, were provided by International Center for Integrated Mountain Development (ICIMOD), Nepal. These ninety nine Apis dorsata honey samples were characterized physicochemical and were found to have values of various quality determining parameters well with in the permissible International standards. The honey samples had pH in the range of 3.8-4.68, free acidity 41-48 meq/kg, lactones 13-16 meq/kg, total acidity 55-65 meq/kg, moisture content 20.5-26%, electrical conductivity 0.22-0.63 mS/cm, proline content 76-160 mg/kg, HMF content 30-56 mg/kg, diastase number 5.1-29 DN, invertase number 390-499, apparent reducing sugars 73.78-77.78%, fructose 36.93-44.61%, glucose 19.61-27.51% and sucrose 12.07-20.38%. (author)

  5. 往复压缩机标准API-618、API-11P的异同点及其应用浅谈%The Similarities and Differences of Reciprocating Compressor Standards of API-618 and API-11P and Discussion of Its Application

    Institute of Scientific and Technical Information of China (English)

    李明悦; 扈滨

    2011-01-01

    PI Standard 618 and API Specification 11P are the standards for reciprocating compressors by American Petroleum Institute ( API) .This paper has speeified the applications of the two standards in the compressors which used in the Cas Treatment Plant of SES natural gas pmject.And the similarities and differences between them are compared.%API Standard 618和API Specification 11P都是美国石油学会(API)针对往复压缩机制定的标准.结合中海石油SES天然气项目中的气体处理厂压缩机单元对这两个标准的应用,对两者之间的异同点进行比较.

  6. R404A/CO_2复叠式制冷系统的火用分析%Exergy analysis of the R404A/CO_2 cascade refrigeration system

    Institute of Scientific and Technical Information of China (English)

    赖艳华; 王庆为; 吕明新; 邵长波; 孔德曼

    2011-01-01

    In order to decrease the energy consumption of the R404A/CO2 cascade refrigeration system,exergy analysis was applied to this system.An exergy analysis method was adopted to obtain the influence of the design and operating parameters on the coefficient of performance ε,the exergy destruction X and the exergetic efficiency ηe of this system.The design and operating parameters include the evaporating temperature Te,the condensing temperature Tk and the temperature difference ΔT in the cascade-condenser.The results indicate that there were a maximum ε,ηe and a minimum Xtot at the same optimal condensing temperature of the cascade-condenser T4opt when Te,Tk and ΔT were constant in the system.It is helpful to reduce X and improve ηe and ε through increasing Te,decreasing Tk and ΔT.The total exergy destructions of the throttling device and the compressor of the R404A circuit,the cascade-condenser and the compressor of the CO2 circuit were 80% of the total exergy destruction of the system.A Multiple linear regression analysis was employed in term of Te,Tk and ΔT to develop mathematics expressions for t4opt,εmaxand ηe,max.%为了降低R404A/CO2复叠式制冷系统的能耗,对该系统进行了能量分析。通过火用分析方法分析系统设计与运行参数对系统性能系数ε、各组成部件及整个系统的火用损X和火用效率ηe的影响。结果表明,在一定蒸发温度Te、冷凝温度Tk和冷凝蒸发器的传热温差ΔT条件下,在相同最佳T4opt时,Xtot取得最小值,ε和ηe取得最大值;为了有利于减小X、提高ηe和ε,应尽量升高Te、降低Tk和ΔT;高温级膨胀阀、压缩机、冷凝蒸发器和低温级压缩机的火用损约占总火用损的80%。对数据进行多重线性回归分析,得到以Te、Tk和ΔT为自变量的t4opt、εmax和ηe,max关系式。

  7. The Ruby UCSC API: accessing the UCSC genome database using Ruby

    Directory of Open Access Journals (Sweden)

    Mishima Hiroyuki

    2012-09-01

    Full Text Available Abstract Background The University of California, Santa Cruz (UCSC genome database is among the most used sources of genomic annotation in human and other organisms. The database offers an excellent web-based graphical user interface (the UCSC genome browser and several means for programmatic queries. A simple application programming interface (API in a scripting language aimed at the biologist was however not yet available. Here, we present the Ruby UCSC API, a library to access the UCSC genome database using Ruby. Results The API is designed as a BioRuby plug-in and built on the ActiveRecord 3 framework for the object-relational mapping, making writing SQL statements unnecessary. The current version of the API supports databases of all organisms in the UCSC genome database including human, mammals, vertebrates, deuterostomes, insects, nematodes, and yeast. The API uses the bin index—if available—when querying for genomic intervals. The API also supports genomic sequence queries using locally downloaded *.2bit files that are not stored in the official MySQL database. The API is implemented in pure Ruby and is therefore available in different environments and with different Ruby interpreters (including JRuby. Conclusions Assisted by the straightforward object-oriented design of Ruby and ActiveRecord, the Ruby UCSC API will facilitate biologists to query the UCSC genome database programmatically. The API is available through the RubyGem system. Source code and documentation are available at https://github.com/misshie/bioruby-ucsc-api/ under the Ruby license. Feedback and help is provided via the website at http://rubyucscapi.userecho.com/.

  8. Correlation between electrical properties and thermodynamic stability of ACoO3-δ perovskites (A= La, Pr, Nd, Sm, Gd)

    International Nuclear Information System (INIS)

    For perovskites with the general formula ACoO3-δ (A = La, Pr, Nd, Sm, and Gd) the influence of the A-site cation on the electrical conductivity, electronic structure, thermodynamic stability, and oxygen stoichiometry was studied. The perovskite oxide powders were produced by a combined citric acid and ethylenediaminetetraacetic acid complexing method. Ceramic specimens sintered at 1100 deg. C in air were single-phase perovskites. With increasing temperature, the electrical conductivity shows three discrete regimes. All compositions show semiconductivity up to a transition temperature of ∼300 deg. C-450 deg. C and then behave like metallic conductors. The activation energies for the semiconductivity, as well as the transition temperatures to the metallic-like conduction, decrease monotonically with increasing pseudocubic lattice parameters, i.e., with increasing ionic radii of the A cation. This behavior correlates with decreasing oxygen nonstoichiometry and increased thermodynamic stability. The highest conductivity and the lowest activation energy of 0.66 eV were found for LaCoO3-δ, which also had the lowest semiconductor-metal transition temperature at 269 deg. C, the lowest oxygen nonstoichiometry of δ= 0.008, and the highest Gibbs free energy change for the decomposition reaction of 42.37 kJ/mol at 850 deg. C. GdCoO3-δ had the highest oxygen nonstoichiometry with δ0.032, a high activation energy of 1.19 eV for the semiconductivity with a high transition temperature at 452 deg. C, and the lowest Gibbs free energy change of 26.54 kJ/mol at 850 deg. C. X-ray absorption spectroscopy data imply an increasing Co low-spin character with decreasing cation radius from La to Gd, while an increase in temperature increases the number of holes or Co 3d bandwidth. This correlates well with the electrical conductivity data.

  9. Transplante cardíaco no Instituto Dante Pazzanese de Cardiologia: análise da sobrevida

    Directory of Open Access Journals (Sweden)

    ASSEF Marco Aurélio Salles

    2001-01-01

    Full Text Available CASUÍSTICA E MÉTODOS: Foram analisados, retrospectivamente, 80 transplantes cardíacos realizados no Instituto Dante Pazzanese de Cardiologia (IDPC no período de novembro de 1991 a agosto de 2000. Houve predomínio do sexo masculino em 70% dos casos e a idade variou de 7 a 69 anos, com média de 44,8 anos. Doze (15% pacientes se encontravam em prioridade, em uso de drogas inotrópicas endovenosas no momento do transplante. As etiologias determinantes da insuficiência cardíaca congestiva grave foram: miocardiopatia dilatada idiopática em 37,5%, miocardiopatia isquêmica em 33,75%, miocardiopatia chagásica em 17,5% e outras causas em 11,25%. Foram realizados 78 transplantes ortotópicos e 2 heterotópicos. A técnica empregada foi bicaval/bipulmonar em 63,75%, atrial em 27,5%, bicaval/unipulmonar em 6,25% e heterotópico em 2,5%. A mortalidade hospitalar (30 dias foi de 18,75%. RESULTADOS: A sobrevida para o transplante ortotópico em um ano foi de 72,7%, em cinco anos 61,5% e em sete anos 56,4%. A sobrevida após o transplante foi correlacionada com as variáveis idade, causa de óbito e sexo do doador, e pelo transplante ter sido ou não a primeira cirurgia cardíaca do paciente.

  10. Aneurisma ilíaco associado a fístula arteriovenosa Iliac aneurysm associated with arteriovenous fistula

    Directory of Open Access Journals (Sweden)

    Daniel Mendes Pinto

    2007-09-01

    Full Text Available A ruptura dos aneurismas aorto-ilíacos para a veia ilíaca ou veia cava é uma complicação pouco comum. A hipertensão venosa leva a vários sinais e sintomas, o que dificulta o diagnóstico pré-operatório, tais como edema do membro inferior, dispnéia, hematúria, sinais de insuficiência renal ou cardíaca. Sopro abdominal é a chave do diagnóstico clínico, associado à massa pulsátil e dor abdominal. O reconhecimento da fístula arteriovenosa no pré-operatório é importante para o planejamento cirúrgico. Relatamos um caso de aneurisma da artéria ilíaca comum e interna direita associado a fístula para veia ilíaca comum, cursando, inicialmente, com edema do membro inferior direito e dispnéia, o que levou ao diagnóstico incorreto de trombose venosa profunda.Rupture of aortoiliac aneurysms into the iliac vein or vena cava is an uncommon complication. Many signs and symptoms develop as a result of venous hypertension, which makes preoperative diagnosis difficult, such as leg edema, dyspnea, hematuria, signs of renal or cardiac insufficiency. Abdominal bruit, associated with pulsatile mass and abdominal pain, is the key for clinical diagnosis. Preoperative recognition of arteriovenous fistula is important for surgical planning. We report a case of right internal and common iliac artery aneurysm associated with fistula into the common iliac vein. Initial symptoms were right leg edema and dyspnea, which induced to the incorrect diagnosis of deep vein thrombosis.

  11. The Arabidopsis apyrase AtAPY1 is localized in the Golgi instead of the extracellular space

    OpenAIRE

    Schiller Madlen; Massalski Carolin; Kurth Thomas; Steinebrunner Iris

    2012-01-01

    Abstract Background The two highly similar Arabidopsis apyrases AtAPY1 and AtAPY2 were previously shown to be involved in plant growth and development, evidently by regulating extracellular ATP signals. The subcellular localization of AtAPY1 was investigated to corroborate an extracellular function. Results Transgenic Arabidopsis lines expressing AtAPY1 fused to the SNAP-(O6-alkylguanine-DNA alkyltransferase)-tag were used for indirect immunofluorescence and AtAPY1 was detected in punctate st...

  12. Asynchronous API Pattern and its Application%异步接口模式及其应用

    Institute of Scientific and Technical Information of China (English)

    何华海; 丁柯

    2002-01-01

    In distributed systems,high efficiency can be achieved using asynchronous API between client and server.This paper provides an architectural pattern that implements asynchronous API generally. Asynchronous methods donot execute operations directly,however,they delegate the sending and receiving process to individual threads via aqueue ,the client deals with results by means of callback ,wait or check. Synchronous API is implemented on the baseof asynchronous API. Presently the asynchronous API pattern has been employed in the implementation of messagequeue middleware ISMQ.

  13. Research on API Based on Visual Programming Platforms%基于可视化平台的 API 接口研究

    Institute of Scientific and Technical Information of China (English)

    关玉蓉

    2015-01-01

    In a variety of visual programming platforms, especially with the external network environment, , a large number of API functions under Windows can help reflect strong advanced programming skills proving to be a multiplier effect. This paper firstly introduces the API function and the dynamic link library DLL, then briefly ex-plains the classification of API functions, and focuses on how to call the API function and its application of API function in the visual platform. The paper finally describes the skills and notes to pay attention for users when call-ing the API function, which enables them to master the advanced programming skills of API interface.%在各种可视化编程平台中,尤其是与外部网络环境相结合,为了体现强大的高级编程能力,可用Windows系统提供的大量API函数,必然会起到事半功倍的效果。本文首先介绍了API函数以及动态链接库DLL,其次简要说明了API函数的分类,然后重点分析了在可视化平台中如何调用API函数及其应用API函数的高级编程能力,最后阐述了用户调用API函数的技巧和注意事项,以提高用户灵活掌握API接口的高级编程应用能力。

  14. Yeast cell factories for fine chemical and API production

    Directory of Open Access Journals (Sweden)

    Glieder Anton

    2008-08-01

    Full Text Available Abstract This review gives an overview of different yeast strains and enzyme classes involved in yeast whole-cell biotransformations. A focus was put on the synthesis of compounds for fine chemical and API (= active pharmaceutical ingredient production employing single or only few-step enzymatic reactions. Accounting for recent success stories in metabolic engineering, the construction and use of synthetic pathways was also highlighted. Examples from academia and industry and advances in the field of designed yeast strain construction demonstrate the broad significance of yeast whole-cell applications. In addition to Saccharomyces cerevisiae, alternative yeast whole-cell biocatalysts are discussed such as Candida sp., Cryptococcus sp., Geotrichum sp., Issatchenkia sp., Kloeckera sp., Kluyveromyces sp., Pichia sp. (including Hansenula polymorpha = P. angusta, Rhodotorula sp., Rhodosporidium sp., alternative Saccharomyces sp., Schizosaccharomyces pombe, Torulopsis sp., Trichosporon sp., Trigonopsis variabilis, Yarrowia lipolytica and Zygosaccharomyces rouxii.

  15. API, Cloud computing, WebGIS and cartography

    Directory of Open Access Journals (Sweden)

    Andrea Favretto

    2013-05-01

    Full Text Available This paper explores some of the digital mapping processes available on the Internet in order to analyse their cartographic congruence. It will focus on WebGIS-based cartography in relation to what is produced using Mash-up site maps. These websites often use Googlebased maps in order to produce their own cartography. Thus, we can identify two main typologies of Internet mapping sites, which are characterized by the ownership or non-ownership of their cartographic bases. This paper will critically assess the cartography employed in the two different instances. A concise introduction to the Cloud Computing Internet propagated phenomenon is also premised in order to provide the reader with an accurate frame of reference. Cloud Computing has encouraged a significant Internet participation via the Application Programming Interface software (API, leading to mash-up cartographic websites.

  16. APIs for QoS configuration in Software Defined Networks

    DEFF Research Database (Denmark)

    Caba, Cosmin Marius; Soler, José

    2015-01-01

    control and management of the data plane (e.g. configurations of ports, queues, etc.). The current work contributes to the SDN ecosystem with the implementation of a plugin for the OVSDB protocol, for an existing SDN controller (SDNC). OVSDB complements OF with management functionality......The OpenFlow (OF) protocol is widely used in Software Defined Networking (SDN) to realize the communication between the controller and forwarding devices. OF allows great flexibility in managing traffic flows. However, OF alone is not enough to build more complex SDN services that require complete...... such as configuration of devices, ports, queues, etc. An Application Programming Interface (API) for dynamic configuration of QoS resources in the network devices is implemented herein, by using the capabilities of OVSDB. Further, the paper demonstrates the possibility to create network services with coarse granularity...

  17. EDGE REMOVAL OF 3D POLYGONAL MODEL USING MAYA API

    Directory of Open Access Journals (Sweden)

    SAMEER ARORA

    2010-09-01

    Full Text Available In various applications of computer graphics, 3D polygonal modeling is used, which consists millions of triangular polygon. In this polygon attributes – vertices, edges and faces’ details are to be stored. In order to control the processing time, storing space, and transfer speed, it is often required to reduce the information ofthese polygonal 3D models. In this paper an effort is made to reduce the number of edges. There are various methods to reduce faces and edges of these 3D models. A C++ dynamic link library as Maya Plugin has been created to remove number of edges of 3D triangular polygon model using the Quadric Error Metrics (QEM in MAYA v2010 x64 API. QEM allows fast and accurate geometric simplification of 3D models.

  18. Design of Continuous Reactor Systems for API Production

    DEFF Research Database (Denmark)

    Pedersen, Michael Jønch

    lifecycle of the API and GMP can make a potential reactor setup non-feasible. If the pharmaceutical industry is to adapt to recent trends towards end-to-end and on-demand pharmaceutical production, access to standard reactor units for commonly-used chemical transformations and methods for timely decision...... in continuous reactor setups. Grignard chemistry encompasses a very powerful reaction type frequently applied in the pharmaceutical industry, for the formation of new carbon-carbon bonds. Three Grignard addition reactions have been studied, all having very different behaviors related to aspects of reaction......-scale production equipment enabled complete replacement of the existing batch production of this intermediate. The crowning achievement in this work was the realization of continuous laboratory reactor setups capable of manufacturing the entire GMP portion of the synthesis of melitracen HCl at H. Lundbeck A...

  19. Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo

    OpenAIRE

    Koci, Lenka; Chlebova, Katarina; Hyzdalova, Martina; Hofmanova, Jirina; Jira, Miroslav; Kysela, Petr; Kozubik, Alois; Kala, Zdenek; Krejci, Pavel

    2012-01-01

    Apoptosis inhibitor 5 (API-5) is a 55 kDa nuclear protein with potent anti-apoptotic signaling in tumor cells in vitro. In this study, we analyzed the expression of the API-5 protein in vivo in a broad spectrum of human carcinomas, including those of the colon, lung, liver, kidney, pancreas, stomach and esophagus using tumor tissues obtained during tumor resection. The results showed significant upregulation of API-5 expression in biopsies of lung (23%, n=13) and colorectal tumors (33%, n=27)...

  20. Clarification of some api characteristics in relation to caribou (Rangifer tarandus

    Directory of Open Access Journals (Sweden)

    William O. Pruitt, Jr.

    1990-09-01

    Full Text Available A total of 2177 comparisons of api hardness vs. density in northern Saskatchewan, southeastern Manitoba and northeastern Finland revealed no consistent correlation (r varied from +.70 to -.17. A total of 1395 comparisons of horizontal hardness of the top layer of api to vertical hardness of the same layer of api in southeastern Manitoba, northeastern Finland and far eastern middle Finland revealed no consistent correlation (r varied from +.99 to -.20. Therefore one cannot substitute density for hardness nor horizontal hardness of the top layer for vertical hardness of the top layer in the terms of the Värriö Snow Index.

  1. The Arabidopsis apyrase AtAPY1 is localized in the Golgi instead of the extracellular space

    Directory of Open Access Journals (Sweden)

    Schiller Madlen

    2012-07-01

    Full Text Available Abstract Background The two highly similar Arabidopsis apyrases AtAPY1 and AtAPY2 were previously shown to be involved in plant growth and development, evidently by regulating extracellular ATP signals. The subcellular localization of AtAPY1 was investigated to corroborate an extracellular function. Results Transgenic Arabidopsis lines expressing AtAPY1 fused to the SNAP-(O6-alkylguanine-DNA alkyltransferase-tag were used for indirect immunofluorescence and AtAPY1 was detected in punctate structures within the cell. The same signal pattern was found in seedlings stably overexpressing AtAPY1-GFP by indirect immunofluorescence and live imaging. In order to identify the nature of the AtAPY1-positive structures, AtAPY1-GFP expressing seedlings were treated with the endocytic marker stain FM4-64 (N-(3-triethylammoniumpropyl-4-(p-diethylaminophenyl-hexatrienyl-pyridinium dibromide and crossed with a transgenic line expressing the trans-Golgi marker Rab E1d. Neither FM4-64 nor Rab E1d co-localized with AtAPY1. However, live imaging of transgenic Arabidopsis lines expressing AtAPY1-GFP and either the fluorescent protein-tagged Golgi marker Membrin 12, Syntaxin of plants 32 or Golgi transport 1 protein homolog showed co-localization. The Golgi localization was confirmed by immunogold labeling of AtAPY1-GFP. There was no indication of extracellular AtAPY1 by indirect immunofluorescence using antibodies against SNAP and GFP, live imaging of AtAPY1-GFP and immunogold labeling of AtAPY1-GFP. Activity assays with AtAPY1-GFP revealed GDP, UDP and IDP as substrates, but neither ATP nor ADP. To determine if AtAPY1 is a soluble or membrane protein, microsomal membranes were isolated and treated with various solubilizing agents. Only SDS and urea (not alkaline or high salt conditions were able to release the AtAPY1 protein from microsomal membranes. Conclusions AtAPY1 is an integral Golgi protein with the substrate specificity typical for Golgi apyrases. It is

  2. Histochemical Comparison of the Hypopharyngeal Gland in Apis cerana Fabricius, 1793 Workers and Apis mellifera Linnaeus, 1758 Workers

    Directory of Open Access Journals (Sweden)

    Guntima Suwannapong

    2010-01-01

    Full Text Available Hypopharyngeal glands of honeybee are age-dependent structures that change with the size of acini and are correlated with various social behaviors. The histochemical structure of Apis cerana and A. mellifera worker hypopharyngeal glands in four different developmental stages wes stained with ninhydrin Schiff's and periodic acid Schiff's reagents (PAS for localization of proteins and carbohydrates, respectively, and examined with light microscopy. Nurse bees of both honeybee species had significantly larger glands as compared to guards and forgers, but there were no statistically significant differences between these two species after accounting for caste. Gland protein concentration increased progressively in nurse bees, and this was correlated with the appearance of enriched protein granules in the cytoplasm. In addition, the hypopharyngeal gland protein concentration of A. mellifera was higher than that of A. cerana even though gland size was not significantly different between species. However, gland size was shown to have decreased progressively in foragers and guards.

  3. Lo prometeico de la naturaleza dionisíaco-apolínea en la forma de sentir y pensar de la poesía de Goethe

    OpenAIRE

    Albanese Pastene, Francisco; Leal Riquelme, Rubén

    2015-01-01

    Utilizando el pensamiento expuesto la obra El Origen de la Tragedia, de Friedrich Nietzsche, en particular lo relacionado con los dioses Apolo y Dionisios, se analizan los componentes dionisíacos y apolíneos en la evolución de lo prometeico en la obras poéticas Prometeo, Límites de lo humano, Lo divino y Uno y todo, de Johann Wolfgang von Goethe Using the ideas articulated in Friedrich Nietzsche's The Birth of Tragedy, especially those related to the gods Apollo and Dionysus...

  4. Contribuição de decavanadato para os efeitos IN VIVO e IN VITRO de vanadato no músculo cardíaco

    OpenAIRE

    Soares, S. S.

    2007-01-01

    Tese dout., Biologia - Fisiologia Animal, Universidade do Algarve, 2007 No presente estudo aborda-se a contribuição da espécie decamérica de vanadato nos efeitos tóxicos in vivo e in vitro de vanadato. Após administração intravenosa de decavanadato em Sparus aurata, o vanadato decamérico induz respostas nos marcadores de stresse oxidativo do tecido cardíaco distintas das promovidas pelo monovanadato, evidenciando a importância de considerar a contribuição dos diferentes olig...

  5. Significados dos episódios maníacos para pacientes com transtorno bipolar em remissão: um estudo qualitativo

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Pereira Bin

    2014-07-01

    Full Text Available Objetivo Discutir os significados da vivência de episódios maníacos para pacientes com transtorno bipolar (TAB. Métodos Trata-se de uma pesquisa qualitativa, feita por meio de entrevistas semidirigidas em profundidade, em uma amostra fechada pelo critério de saturação com oito pacientes com TAB em remissão. A técnica de tratamento de dados foi feita por meio da análise de conteúdo das entrevistas transcritas na íntegra e categorização. Os resultados foram submetidos à validação externa, no Laboratório de Pesquisa Clínico-Qualitativa do Departamento de Psicologia Médica e Psiquiatria da Unicamp, composto por 37 pesquisadores do método, entre eles mestrandos, doutorandos, pós-doutorados e pesquisadores seniores. Resultados Foram identificadas três categorias – Ambivalência e vergonha: pensar ou não pensar sobre os episódios maníacos; Organizando sentimentos pessoais: a remissão como um momento de autoconsciência; Episódios maníacos estruturando relações interpessoais versus projeções da angústia. Conclusão Os achados da presente pesquisa contribuem para a maior compreensão dos quadros maníacos no TAB, que podem auxiliar nas reflexões acerca da relação profissional-paciente, para elaborar estratégias para aderência e para as medidas terapêuticas e preventivas da recorrência dos episódios. Podem auxiliar a equipe de saúde envolvida no acompanhamento desses casos e também os pesquisadores na investigação da contribuição dos significados aqui discutidos nos fenômenos de aderência ao tratamento e de um melhor prognóstico.

  6. QUINOA (CHENOPODIUM QUINOA WILLD): DIGESTIBILIDADE IN VITRO, DESENVOLVIMENTO E ANÁLISE SENSORIAL DE PREPARAÇÕES DESTINADAS A PACIENTES CELÍACOS

    OpenAIRE

    L. I. A. CASTRO; C. M. V. REAL; I. S. C. PIRES; C. V. PIRES; N. A.V.D. PINTO; Miranda, L. S.; B. C. ROSA; P. A. DIAS

    2008-01-01

    A quinoa (Chenopodium quinoa Willd) é um pseudocereal isento de glúten, oriundo dos Andes, onde tem sido cultivado há milhares de anos. O objetivo deste trabalho foi desenvolver e avaliar sensorialmente algumas preparações contendo quinoa em grãos, flocos e farinha, destinadas ao paciente celíaco, e determinar a digestibilidade in vitro de sua proteína, submetida ou ...

  7. Espectro óculo-aurículo-vertebral em pacientes com defeitos cardíacos congênitos

    Directory of Open Access Journals (Sweden)

    Rafael Fabiano Machado Rosa

    2010-10-01

    Full Text Available FUNDAMENTO: Há poucos estudos avaliando a frequência do espectro óculo-aurículo-vertebral (EOAV nos pacientes com defeitos cardíacos congênitos (DCC. OBJETIVO: Verificar a frequência do EOAV em uma amostra de pacientes com malformações cardíacas graves. MÉTODOS: Avaliamos uma coorte prospectiva de pacientes com DCC, admitidos em uma unidade de terapia intensiva (UTI cardiopediátrica no Brasil. O diagnóstico de EOAV foi feito com base em dados clínicos, considerando critérios padrões. Os pacientes que preenchiam esses critérios foram submetidos ao cariótipo de alta resolução com bandamento GTG e hibridização fluorescente in situ para a microdeleção 22q11.2. O teste exato de Fisher (P < 0,05 foi usado para as análises estatísticas. RESULTADOS: Durante o período de avaliação, 330 pacientes foram hospitalizados pela primeira vez na UTI, mas trinta deles não participaram deste estudo. Dos 300 pacientes que constituíram a amostragem final, o EOAV foi verificado em três casos (1%. Todos apresentaram estudos citogenéticos normais. CONCLUSÃO: O EOAV parece ser uma condição frequente em pacientes com DCC. Contudo, não podemos excluir a possibilidade de que a frequência de EOAV encontrada em nosso estudo possa ter sido subestimada devido à baixa taxa de detecção pré-natal de DCC e ao acesso limitado dos pacientes ao tratamento médico apropriado em nosso meio. Estudos prospectivos futuros com critérios clínicos bem definidos e pacientes com defeitos leves e graves serão importantes para avaliar o papel do EOAV na população em geral de indivíduos com malformações cardíacas.

  8. BUILDING MODEL ANALYSIS APPLICATIONS WITH THE JOINT UNIVERSAL PARAMETER IDENTIFICATION AND EVALUATION OF RELIABILITY (JUPITER) API

    Science.gov (United States)

    The open-source, public domain JUPITER (Joint Universal Parameter IdenTification and Evaluation of Reliability) API (Application Programming Interface) provides conventions and Fortran-90 modules to develop applications (computer programs) for analyzing process models. The input ...

  9. A new detrended semipartial cross-correlation analysis: Assessing the important meteorological factors affecting API

    Science.gov (United States)

    Shen, Chen-Hua

    2015-12-01

    To analyze the unique contribution of meteorological factors to the air pollution index (API), a new method, the detrended semipartial cross-correlation analysis (DSPCCA), is proposed. Based on both a detrended cross-correlation analysis and a DFA-based multivariate-linear-regression (DMLR), this method is improved by including a semipartial correlation technique, which is used to indicate the unique contribution of an explanatory variable to multiple correlation coefficients. The advantages of this method in handling nonstationary time series are illustrated by numerical tests. To further demonstrate the utility of this method in environmental systems, new evidence of the primary contribution of meteorological factors to API is provided through DMLR. Results show that the most important meteorological factors affecting API are wind speed and diurnal temperature range, and the explanatory ability of meteorological factors to API gradually strengthens with increasing time scales. The results suggest that DSPCCA is a useful method for addressing environmental systems.

  10. Telephone Interpreter Services (TIS)-Asian and Pacific Islander (API) Language Yearly Dataset

    Data.gov (United States)

    Social Security Administration — This dataset displays our national TIS call volume for over 45 API languages for the last three fiscal years. A fiscal year runs from October through September. We...

  11. Candida albicans response to spaceflight (NASA STS-115) --- GSM1231690_Slide_43 API

    Data.gov (United States)

    National Aeronautics and Space Administration — A fully queryable REST API with JSON, XML, and CSV output as well as inline, runable examples using data from the transcriptional profiling and phenotypic...

  12. A E- GEOD-50881 Gene Chip Assay --- Candida albicans response to spaceflight (NASA STS-115) API

    Data.gov (United States)

    National Aeronautics and Space Administration — A fully queryable REST API with JSON, XML, and CSV output as well as inline, runable examples using data from the transcriptional profiling and phenotypic...

  13. S E- GEOD-50881 Study Samples --- Candida albicans response to spaceflight (NASA STS-115) API

    Data.gov (United States)

    National Aeronautics and Space Administration — A fully queryable REST API with JSON, XML, and CSV output as well as inline, runable examples using data from the transcriptional profiling and phenotypic...

  14. NSLS-II High Level Application Infrastructure And Client API Design

    International Nuclear Information System (INIS)

    The beam commissioning software framework of NSLS-II project adopts a client/server based architecture to replace the more traditional monolithic high level application approach. It is an open structure platform, and we try to provide a narrow API set for client application. With this narrow API, existing applications developed in different language under different architecture could be ported to our platform with small modification. This paper describes system infrastructure design, client API and system integration, and latest progress. As a new 3rd generation synchrotron light source with ultra low emittance, there are new requirements and challenges to control and manipulate the beam. A use case study and a theoretical analysis have been performed to clarify requirements and challenges to the high level applications (HLA) software environment. To satisfy those requirements and challenges, adequate system architecture of the software framework is critical for beam commissioning, study and operation. The existing traditional approaches are self-consistent, and monolithic. Some of them have adopted a concept of middle layer to separate low level hardware processing from numerical algorithm computing, physics modelling, data manipulating, plotting, and error handling. However, none of the existing approaches can satisfy the requirement. A new design has been proposed by introducing service oriented architecture technology. The HLA is combination of tools for accelerator physicists and operators, which is same as traditional approach. In NSLS-II, they include monitoring applications and control routines. Scripting environment is very important for the later part of HLA and both parts are designed based on a common set of APIs. Physicists and operators are users of these APIs, while control system engineers and a few accelerator physicists are the developers of these APIs. With our Client/Server mode based approach, we leave how to retrieve information to the

  15. Antagonistic Effect of Gut Bacteria in the Hybrid Carniolan Honey Bee, Apis Mellifera Carnica, Against Ascosphaera Apis, the Causal Organism of Chalkbrood Disease

    Directory of Open Access Journals (Sweden)

    Omar Mohamed O. M.

    2014-06-01

    Full Text Available The objective of this study was to isolate and characterize bacterial strains associated with the gut of the hybrid Carniolan honey bee, Apis mellifera carnica, and to determine their in vitro and in vivo potential against Ascosphaera apis, the causal organism of chalkbrood disease, with the purpose of exploring feasible biological control. Six bacterial strains were isolated from healthy worker honey bees by culture-dependent methods. Six fungal strains (A3, A4, A7, A8, A9, and A15 of A. apis were isolated from larvae suffering from chalkbrood disease on Yeast-Glucose-Starch agar (YGPSA medium. All bacteria were identified by a combination of morphology, Gram stain, and 16S rRNA sequence analysis, and fungal strains were identified by morphology and 5.8S rRNA. In vitro and in vivo inhibition assays were carried out to determine the ability of bacterial isolates to inhibit A. apis, the causal agent of chalkbrood disease. The analysis of 16S rRNA sequences revealed that four bacterial strains (B2, B4, B10, and B100 belong to Bacillus subtilis species, and two strains (P1 and P5 belong to Pseudomonas fluorescence. Significant differences in antagonistic activity of all bacterial strains were observed. B. subtilis isolate B2 showed the highest antagonistic activity, as measured by the inhibition zone against A. apis, followed by the P1 strain of P. fluorescence. SEM analysis also supports the antagonistic activity of these bacteria against A. apis. This study provides a theoretical basis for biological control of honey bee chalkbrood disease.

  16. Using the RxNorm Web Services API for Quality Assurance Purposes

    OpenAIRE

    Peters, Lee; Bodenreider, Olivier

    2008-01-01

    Auditing large, rapidly evolving terminological systems is still a challenge. In the case of RxNorm, a standardized nomenclature for clinical drugs, we argue that quality assurance processes can benefit from the recently released application programming interface (API) provided by RxNav. We demonstrate the usefulness of the API by performing a systematic comparison of alternative paths in the RxNorm graph, over several thousands of drug entities. This study revealed potential errors in RxNorm...

  17. Atmospheric sulphuric acid and neutral cluster measurements using CI-APi-TOF

    OpenAIRE

    Jokinen, T; Sipilä, M.; Junninen, H.; M. Ehn; Lönn, G.; Hakala, J.; T. Petäjä; R. L. Mauldin III; M. Kulmala; Worsnop, D.R.

    2011-01-01

    The first ambient measurements using nitrate ion based Chemical Ionization with the Atmospheric Pressure interface Time-Of-Flight mass spectrometer (CI-APi-TOF) for sulphuric acid and neutral cluster detection are presented. We have found CI-APi-TOF a highly stable and sensitive tool for molecular sulphuric acid detection. The lowest limit of detection for sulphuric acid was determined to be 3 × 104 molecules cm−3 for two hour averaging. Si...

  18. Sensitivity Analysis of Fatigue Crack Growth Model for API Steels in Gaseous Hydrogen.

    Science.gov (United States)

    Amaro, Robert L; Rustagi, Neha; Drexler, Elizabeth S; Slifka, Andrew J

    2014-01-01

    A model to predict fatigue crack growth of API pipeline steels in high pressure gaseous hydrogen has been developed and is presented elsewhere. The model currently has several parameters that must be calibrated for each pipeline steel of interest. This work provides a sensitivity analysis of the model parameters in order to provide (a) insight to the underlying mathematical and mechanistic aspects of the model, and (b) guidance for model calibration of other API steels.

  19. A RESTful API for accessing microbial community data for MG-RAST.

    Directory of Open Access Journals (Sweden)

    Andreas Wilke

    2015-01-01

    Full Text Available Metagenomic sequencing has produced significant amounts of data in recent years. For example, as of summer 2013, MG-RAST has been used to annotate over 110,000 data sets totaling over 43 Terabases. With metagenomic sequencing finding even wider adoption in the scientific community, the existing web-based analysis tools and infrastructure in MG-RAST provide limited capability for data retrieval and analysis, such as comparative analysis between multiple data sets. Moreover, although the system provides many analysis tools, it is not comprehensive. By opening MG-RAST up via a web services API (application programmers interface we have greatly expanded access to MG-RAST data, as well as provided a mechanism for the use of third-party analysis tools with MG-RAST data. This RESTful API makes all data and data objects created by the MG-RAST pipeline accessible as JSON objects. As part of the DOE Systems Biology Knowledgebase project (KBase, http://kbase.us we have implemented a web services API for MG-RAST. This API complements the existing MG-RAST web interface and constitutes the basis of KBase's microbial community capabilities. In addition, the API exposes a comprehensive collection of data to programmers. This API, which uses a RESTful (Representational State Transfer implementation, is compatible with most programming environments and should be easy to use for end users and third parties. It provides comprehensive access to sequence data, quality control results, annotations, and many other data types. Where feasible, we have used standards to expose data and metadata. Code examples are provided in a number of languages both to show the versatility of the API and to provide a starting point for users. We present an API that exposes the data in MG-RAST for consumption by our users, greatly enhancing the utility of the MG-RAST service.

  20. GLAME@lab: An M-script API for Linear Algebra Operations on Graphics Processors

    OpenAIRE

    Barrachina Mir, Sergio; Castillo Catalán, Maribel; Igual Peña, Francisco Daniel; Mayo, Rafael; Quintana Ortí, Enrique S.

    2008-01-01

    We propose two high-level application programming interfaces (APIs) to use a graphics processing unit (GPU) as a coprocessor for dense linear algebra operations. Combined with an extension of the FLAME API and an implementation on top of NVIDIA CUBLAS, the result is an efficient and user-friendly tool to design, implement, and execute dense linear algebra operations on the current generation of NVIDIA graphics processors, of wide-appeal to scientists and engineers. As an applicati...

  1. Differential gene expression of the honey bee Apis mellifera associated with Varroa destructor infection

    OpenAIRE

    Evans JD; Robinson GE; Martin-Magniette ML; Alaux C; Migeon A; Navajas M; Cros-Arteil S; Crauser D; Le Conte Y

    2008-01-01

    Abstract Background The parasitic mite, Varroa destructor, is the most serious pest of the western honey bee, Apis mellifera, and has caused the death of millions of colonies worldwide. This mite reproduces in brood cells and parasitizes immature and adult bees. We investigated whether Varroa infestation induces changes in Apis mellifera gene expression, and whether there are genotypic differences that affect gene expression relevant to the bee's tolerance, as first steps toward unravelling m...

  2. Revoke and Let Live: A Secure Key Revocation API for Cryptographic Devices

    OpenAIRE

    V\\xe9ronique Cortier; Graham Steel; Cyrille Wiedling

    2012-01-01

    While extensive research addresses the problem of establishing session keys through cryptographic protocols, relatively little work has appeared addressing the problem of revocation and update of long term keys. We present an API for symmetric key management on embedded devices that supports revocation and prove security properties design in the symbolic model of cryptography. Our API supports two modes of revocation: a passive mode where keys have an expiration time, and an active mode where...

  3. Identification of Staphylococcus species with the API STAPH-IDENT system.

    OpenAIRE

    1982-01-01

    The API STAPH-IDENT system was compared with conventional methods for the identification of 14 Staphylococcus species. Conventional methods included the Kloos and Schleifer simplified scheme and DNA-DNA hybridization. The API STAPH-IDENT strip utilizes a battery of 10 miniaturized biochemical tests, including alkaline phosphatase, urease, beta-glucosidase, beta-glucuronidase, and beta-galactosidase activity, aerobic acid formation from D-(+)-mannose, D-mannitol, D-(+)-trehalose, and salicin, ...

  4. Sensitivity Analysis of Fatigue Crack Growth Model for API Steels in Gaseous Hydrogen

    Science.gov (United States)

    Amaro, Robert L; Rustagi, Neha; Drexler, Elizabeth S; Slifka, Andrew J

    2014-01-01

    A model to predict fatigue crack growth of API pipeline steels in high pressure gaseous hydrogen has been developed and is presented elsewhere. The model currently has several parameters that must be calibrated for each pipeline steel of interest. This work provides a sensitivity analysis of the model parameters in order to provide (a) insight to the underlying mathematical and mechanistic aspects of the model, and (b) guidance for model calibration of other API steels. PMID:26601024

  5. Extensive population admixture on drone congregation areas of the giant honeybee, Apis dorsata (Fabricius, 1793)

    OpenAIRE

    Beaurepaire, Alexis L; Kraus, Bernard F; Koeniger, Gudrun; KOENIGER, Nikolaus; Lim, Herbert; Moritz, Robin F.A.

    2014-01-01

    The giant honeybee Apis dorsata often forms dense colony aggregations which can include up to 200 often closely related nests in the same location, setting the stage for inbred matings. Yet, like in all other Apis species, A. dorsata queens mate in mid-air on lek like drone congregation areas (DCAs) where large numbers of males gather in flight. We here report how the drone composition of A. dorsata DCAs facilitates outbreeding, taking into the account both spatial (three DCAs) and temporal (...

  6. Characterization of transcriptional profiles of MA-ACS1 and MA-ACO1 genes in response to ethylene, auxin, wounding, cold and different photoperiods during ripening in banana fruit.

    Science.gov (United States)

    Choudhury, Swarup Roy; Roy, Sujit; Sengupta, Dibyendu N

    2008-12-01

    The ripening-specific genes MA-ACS1 (Musa acuminata ACC synthase1) and MA-ACO1 (M. acuminata ACC oxidase 1) are regulated in response to a wide variety of factors. Here, we have studied the differential transcript accumulation pattern and protein levels of MA-ACS1 and MA-ACO1 genes in response to ethylene, auxin, wounding and low temperature in preclimacteric banana fruit. We have shown that exogenous application of ethylene and auxin induced the expression of MA-ACS1, while MA-ACO1 showed marginal expression following ethylene treatment in preclimacteric stage. Auxin did not induce MA-ACO1 expression. Thus, auxin-treated banana fruits showed lower ethylene production rate as compared to ethylene-treated fruits. Conversely, wounding and cold treatment down-regulated the expression of both the genes and thus inhibited ethylene production. Furthermore, we have detected a GCC-box putative ethylene-responsive element (ERE)- and an auxin-responsive element (ARE)-specific DNA-binding activity in the banana pulp and studied the ethylene and auxin responsive characteristics of the GCC-box and ARE (TGTCTC) containing synthetic promoter fragments. In addition, we have detected an enhanced ethylene production rate and expression level of MA-ACS1 and MA-ACO1 genes along with a strong GCC-box-specific DNA-binding activity following exposure to constant dark period for 8d at the preclimacteric stage. Together, our study provides interesting information about the regulation of expression of MA-ACS1 and MA-ACO1 genes in response to various factors during ripening in banana fruit, which may have physiological relevance concerning ethylene biosynthesis during post-harvest conditions.

  7. Genome-wide characterization of long intergenic non-coding RNAs (lincRNAs) provides new insight into viral diseases in honey bees Apis cerana and Apis mellifera

    OpenAIRE

    Jayakodi, Murukarthick; Jung, Je Won; Park, Doori; Ahn, Young-Joon; Lee, Sang-Choon; Shin, Sang-Yoon; Shin, Chanseok; Yang, Tae-Jin; Kwon, Hyung Wook

    2015-01-01

    Background Long non-coding RNAs (lncRNAs) are a class of RNAs that do not encode proteins. Recently, lncRNAs have gained special attention for their roles in various biological process and diseases. Results In an attempt to identify long intergenic non-coding RNAs (lincRNAs) and their possible involvement in honey bee development and diseases, we analyzed RNA-seq datasets generated from Asian honey bee (Apis cerana) and western honey bee (Apis mellifera). We identified 2470 lincRNAs with an a...

  8. Advance Payment ACO Model

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Advance Payment Model is designed for physician-based and rural providers who have come together voluntarily to give coordinated high quality care to the...

  9. ACO - Ant Colony Optimization

    OpenAIRE

    Žumer, Viljem; Brest, Janez; Pešl, Ivan

    2015-01-01

    Ant colony optimization is a relatively new approach to solving NP-Hard problems. It is based on the behavior of real ants, which always find the shortest path between their nest and a food source. Such behavior can be transferred into the discrcte world, were real ants are replaced by simple agents. Such simple agents are placed into the environment where different combinatorial problems can be solved In this paper we describe an artificial ant colony capable of solving the travelling salesm...

  10. Hot-Stage Microscopy for Determination of API Particles in a Formulated Tablet

    Directory of Open Access Journals (Sweden)

    Michal Šimek

    2014-01-01

    Full Text Available Although methods exist to readily determine the particle size distribution (PSD of an active pharmaceutical ingredient (API before its formulation into a final product, the primary challenge is to develop a method to determine the PSD of APIs in a finished tablet. To address the limitations of existing PSD methods, we used hot-stage microscopy to observe tablet disintegration during temperature change and, thus, reveal the API particles in a tablet. Both mechanical and liquid disintegration were evaluated after we had identified optimum milling time for mechanical disintegration and optimum volume of water for liquid disintegration. In each case, hot-stage micrographs, taken before and after the API melting point, were compared with image analysis software to obtain the PSDs. Then, the PSDs of the APIs from the disintegrated tablets were compared with the PSDs of raw APIs. Good agreement was obtained, thereby confirming the robustness of our methodology. The availability of such a method equips pharmaceutical scientists with an in vitro assessment method that will more reliably determine the PSD of active substances in finished tablets.

  11. The Matchmaker Exchange API: automating patient matching through the exchange of structured phenotypic and genotypic profiles.

    Science.gov (United States)

    Buske, Orion J; Schiettecatte, François; Hutton, Benjamin; Dumitriu, Sergiu; Misyura, Andriy; Huang, Lijia; Hartley, Taila; Girdea, Marta; Sobreira, Nara; Mungall, Chris; Brudno, Michael

    2015-10-01

    Despite the increasing prevalence of clinical sequencing, the difficulty of identifying additional affected families is a key obstacle to solving many rare diseases. There may only be a handful of similar patients worldwide, and their data may be stored in diverse clinical and research databases. Computational methods are necessary to enable finding similar patients across the growing number of patient repositories and registries. We present the Matchmaker Exchange Application Programming Interface (MME API), a protocol and data format for exchanging phenotype and genotype profiles to enable matchmaking among patient databases, facilitate the identification of additional cohorts, and increase the rate with which rare diseases can be researched and diagnosed. We designed the API to be straightforward and flexible in order to simplify its adoption on a large number of data types and workflows. We also provide a public test data set, curated from the literature, to facilitate implementation of the API and development of new matching algorithms. The initial version of the API has been successfully implemented by three members of the Matchmaker Exchange and was immediately able to reproduce previously identified matches and generate several new leads currently being validated. The API is available at https://github.com/ga4gh/mme-apis. PMID:26255989

  12. An analysis of multifractal characteristics of API time series in Nanjing, China

    Science.gov (United States)

    Shen, Chen-hua; Huang, Yi; Yan, Ya-ni

    2016-06-01

    This paper describes multifractal characteristics of daily air pollution index (API) records in Nanjing from 2001 to 2012. The entire daily API time series is first divided into 12 parts that serve as research objects, and the generalized Hurst exponent is calculated for each series. And then, the multifractal sources are analyzed and singularity spectra are shown. Next, based on a singularity spectrum, the multifractal-characteristics parameters (maximum exponent α0, spectrum width Δ α, and asymmetry Δ αas) are introduced. The results show that the fractality of daily API for each year is multifractal. The multifractal sources originate from both a broad probability density function and different long-range correlations with small and large fluctuations. The strength of the distribution multifractality is stronger than that of the correlation multifractality. The variation in the structure of API time series with increasing years is mainly related to long-range correlations. The structure of API time series in some years is richer. These findings can provide a scientific basis for further probing into the complexity of API.

  13. Dynamics and performance of the free electron laser at Super-Aco with a harmonic RF cavity set on 500 MHz

    International Nuclear Information System (INIS)

    This work is dedicated to the development of the potentialities of the free electron laser that has been installed on the storage ring Super-Aco at Orsay university. We have studied the dynamics of the electron beam inside a harmonic RF cavity set on 500 MHz. The impact of the geometric characteristics of the optical cavity on the transverse overlapping between laser radiation and the electron beam has been studied in details. An important part of the work has been the assessment of the optical characterization of the dielectric multi-layer mirrors of the cavity. For that purpose a complete system has been designed to assess the changes in optical properties of mirrors during laser operation. Another important part of this work was the study of the interaction process between laser radiation and the electron bunch leading to saturation. This interaction process has been simulated through a new model and some predictions given by this model have been successfully confronted to experimental data. The installation of the harmonic RF cavity has led to a significant increase of the laser radiation gain and the value of the mean power of the laser radiation has reached 300 mW. An interesting application of this technique is the generation of high energy gamma photons through Compton backscattering. A collimated 35 MeV-energy photon beam has been produced at Super-Aco with a rate of 5.106 photons per second. (A.C.)

  14. Tamponamento cardíaco em dois recém-nascidos causado por cateter umbilical Cardiac tamponade caused by central venous catheter in two newborns

    Directory of Open Access Journals (Sweden)

    Andrey José Monteiro

    2008-09-01

    Full Text Available Tamponamento cardíaco secundário ao uso de cateter venoso central é uma complicação rara, porém potencialmente tratável, quando identificada a tempo. Nós relatamos dois casos de tamponamento cardíaco, diagnosticados por ecocardiograma transtorácico, seguido de pericardiocentese de urgência e drenagem pericárdica cirúrgica como complicação de cateterização venosa umbilical. Em um caso, a ponta do cateter estava adequadamente localizada e, no outro caso, não. Em ambos os casos, solução hiperosmolar estava sendo infundida. Apesar de situação incomum, esta deve ser sempre considerada em neonato, evoluindo com choque cardiogênico sem causa aparente.Cardiac tamponade secondary to the use of central venous catheter is a rare complication; however, it is potentially reversible when it is caught in time. We report two cases of cardiac tamponade that was diagnosed using a transthoracic echocardiography, followed by urgent pericardiocentesis and surgical pericardial drainage as a complication from umbilical venous catheterization. In one case, the tip of the catheter was properly placed, and in the other case, it was not. In both cases, a hyperosmolar solution was being injected. Although it may be an uncommon situation, it should be always considered as a possibility in a newborn who develops cardiogenic shock without an apparent cause.

  15. Análisis de la calidad del registro de paro cardíaco en casos de responsabilidad médico legal en médicos generales, 1999-2007

    OpenAIRE

    Barragán, Gabriel; Navarro Vargas, José Ricardo; Marulanda, Nathalie; Eslava Schmalbach, Javier Hernando

    2010-01-01

    Antecedentes. El registro del paro cardíaco es una actividad que se debe acompañar en la reanimación cerebro cardio pulmonar. En Colombia no existe un formato de registro oficial de paro cardiorrespiratorio, lo que dificulta la investigación en reanimación y la conducción de los procesos de responsabilidad médica que se deriven de esta atención. Objetivo. Analizar la calidad del registro de paro cardíaco en casos de responsabilidad médico legal iniciada a médicos generales que tuvieron as...

  16. GASTO CARDÍACO MATERNO COMO PREDICTOR DEL SÍNDROME DE PREECLAMPSIA-ECLAMPSIA / Maternal cardiac output as a predictor of preeclampsia-eclampsia syndrome

    Directory of Open Access Journals (Sweden)

    Luis A. Díaz Moreno

    2012-03-01

    Full Text Available Resumen Introducción y objetivos: La hipertensión es la complicación médica más común del embarazo, y puede dejar secuelas permanentes como: alteraciones neurológicas, hepáticas, hematológicas o renales. Cada tres minutos muere una mujer debido a la preeclampsia. Durante el embarazo el gasto cardíaco sufre un incremento de hasta 40 %. Este incremento es secundario al aumento de aproximadamente 30 % del volumen sistólico. El objetivo de la investigación fue predecir la aparición del síndrome de preeclampsia-eclampsia mediante la identificación de alteraciones del gasto cardíaco. Método: Se realizó un estudio observacional, descriptivo, longitudinal y analítico, de cohorte prospectiva, donde se determinó, por ecocardiografía, el gasto cardíaco en 31 embarazadas, entre las semanas 11 y 13,6 de gestación como único valor; y mediante seguimiento prenatal, se observó la aparición o no del síndrome de Preeclampsia-Eclampsia. Resultados: Se logró el seguimiento de 31 embarazadas a las que se le midió el gasto cardíaco, y se encontró una prevalecía de la enfermedad de 12,9 % con un 64,5 % de pacientes correctamente diagnosticados, con una sensibilidad de 75 %, con valor predictivo positivo de 23 %, especificidad de 62 % y valor predictivo negativo de 94%, con un riesgo relativo de 4,1 (intervalo de confianza 95 %, 0,48-35,6. Conclusiones: Es posible establecer la medición de gasto cardíaco como estudio de escrutinio para predecir la aparición del síndrome de Preeclampsia desde el control prenatal, y contribuir así a la disminución de la muerte materna. / Abstract Introduction and Objectives: Hypertension is the most common medical complication of pregnancy, and it can leave permanent sequelae such as neurological, hepatic, hematological or renal disorders. Every three minutes a woman dies due to preeclampsia. During pregnancy, cardiac output suffers an increase of 40%. This increase is secondary to an increase of

  17. Mating flights select for symmetry in honeybee drones ( Apis mellifera)

    Science.gov (United States)

    Jaffé, Rodolfo; Moritz, Robin F. A.

    2010-03-01

    Males of the honeybee ( Apis mellifera) fly to specific drone congregation areas (DCAs), which virgin queens visit in order to mate. From the thousands of drones that are reared in a single colony, only very few succeed in copulating with a queen, and therefore, a strong selection is expected to act on adult drones during their mating flights. In consequence, the gathering of drones at DCAs may serve as an indirect mate selection mechanism, assuring that queens only mate with those individuals having a better flight ability and a higher responsiveness to the queen’s visual and chemical cues. Here, we tested this idea relying on wing fluctuating asymmetry (FA) as a measure of phenotypic quality. By recapturing marked drones at a natural DCA and comparing their size and FA with a control sample of drones collected at their maternal hives, we were able to detect any selection on wing size and wing FA occurring during the mating flights. Although we found no solid evidence for selection on wing size, wing FA was found to be significantly lower in the drones collected at the DCA than in those collected at the hives. Our results demonstrate the action of selection during drone mating flights for the first time, showing that developmental stability can influence the mating ability of honeybee drones. We therefore conclude that selection during honeybee drone mating flights may confer some fitness advantages to the queens.

  18. The Influence of Niobium on SSC Resistance in API Steels

    Energy Technology Data Exchange (ETDEWEB)

    Malina, J.; Malina, M.; Novosel-Radovic, V. [Zagreb Univ., Faculty of Metallurgy (Croatia)

    2004-07-01

    Full text of publication follows: Oil country tubular goods are often exposed to aggressive sour environments in oil wells where H{sub 2}S promotes sulfide stress cracking, SSC. This is one of the most dangerous corrosion phenomena characterized by unpredictable and sudden cracking of steel constructions in service. SSC results in a variety of fracture features having a common relationship to the presence of hydrogen in metal and therefore it belongs to hydrogen embrittlement phenomena, HE. For the production of sulfide stress cracking resistant (SSC) tubing from steels included in Group 3 of API Specification 5CT, in this study two experimental Cr-Mo steels (without niobium and with niobium microalloyed) were tested. The influence of Nb precipitates in pipeline steels on the sensitivity to sulfide stress cracking was examined in laboratory experiments using three point bent beam tests. High mechanical properties were achieved through quenching and tempering procedures. Better corrosion resistance of Nb-containing steel is the consequence of microstructural parameters obtained through strengthening mechanism with microalloying element. Besides the usual mechanical, metallographic, SEM and TEM analyses, as complementary method the X-ray diffraction was used. It was revealed that tetragonality of crystal lattice, dislocation density and residual stresses are in good correlation with Sc-vales from corrosion tests. Nb precipitates (especially niobium carbides) have beneficial influence when producing the steels with low sensitivity to SSC. (authors)

  19. Custom synthesis of isotope-labelled Apis mellifera Pheromone

    International Nuclear Information System (INIS)

    The object of this study is to determine the optimum conditions for the synthesis of the isotope-labelled isopentyl acetate. Isopentyl acetate is widely used as a raw material in industries, in syntheses, and is utilized as a sex attractant (pheromone) by the bee species, Apis mellifera. The isotope labelling of isopentyl acetate will allow tracking of the fate and movement of the isopentyl acetate in the environment, in chemical transformations, and in biological systems. Esterification by alcoholysis of acetic acid was optimized for the preparation of Carbon-14(14C)-labelled isopentyl acetate from 14C-labelled acetic acid and isoamyl alcohol. The different conditions studied were: (1) The effects of acid catalysis and/or reflux on the incorporation and retention of the isotope label on the product. The efficiency of label incorporation and retention was determined through the beta radioactivity of Carbon 14 in each of the synthetic constructs. Determination of the beta radioactivity concentration of 14C in the isopentyl acetate product was done using low level liquid scintillation spectrometry. Each of the synthetic products was mixed with Ultima Gold scintillation cocktail in a low potassium glass scintillation vial, and analysed in a low-level Wallac 1414 scintillation counter. The application of catalysis without reflux resulted in the highest yield (35%). The same condition also resulted in the highest abundance of carbon isotope label with 2.40 Bequerels per cubic centimetre, Bq/cc (measurement unit for radioactivity). (author)

  20. Mating flights select for symmetry in honeybee drones (Apis mellifera).

    Science.gov (United States)

    Jaffé, Rodolfo; Moritz, Robin F A

    2010-03-01

    Males of the honeybee (Apis mellifera) fly to specific drone congregation areas (DCAs), which virgin queens visit in order to mate. From the thousands of drones that are reared in a single colony, only very few succeed in copulating with a queen, and therefore, a strong selection is expected to act on adult drones during their mating flights. In consequence, the gathering of drones at DCAs may serve as an indirect mate selection mechanism, assuring that queens only mate with those individuals having a better flight ability and a higher responsiveness to the queen's visual and chemical cues. Here, we tested this idea relying on wing fluctuating asymmetry (FA) as a measure of phenotypic quality. By recapturing marked drones at a natural DCA and comparing their size and FA with a control sample of drones collected at their maternal hives, we were able to detect any selection on wing size and wing FA occurring during the mating flights. Although we found no solid evidence for selection on wing size, wing FA was found to be significantly lower in the drones collected at the DCA than in those collected at the hives. Our results demonstrate the action of selection during drone mating flights for the first time, showing that developmental stability can influence the mating ability of honeybee drones. We therefore conclude that selection during honeybee drone mating flights may confer some fitness advantages to the queens.

  1. SIP APIs for Voice and Video Communications on the Web

    CERN Document Server

    Davids, Carol; Singh, Kundan; Sinnreich, Henry; Wimmreuter, Wilhelm

    2011-01-01

    Existing standard protocols for the web and Internet telephony fail to deliver real-time interactive communication from within a web browser. In particular, the client-server web protocol over reliable TCP is not always suitable for end-to-end low latency media path needed for interactive voice and video communication. To solve this, we compare the available platform options using the existing technologies such as modifying the web programming language and protocol, using an existing web browser plugin, and a separate host resident application that the web browser can talk to. We argue that using a separate application as an adaptor is a promising short term as well as long-term strategy for voice and video communications on the web. Our project aims at developing the open technology and sample implementations for web-based real-time voice and video communication applications. We describe the architecture of our project including (1) a RESTful web communication API over HTTP inspired by SIP message flows, (2)...

  2. Molecular characterization of hemoglobin from the honeybee Apis mellifera.

    Science.gov (United States)

    Hankeln, Thomas; Klawitter, Sabine; Krämer, Melanie; Burmester, Thorsten

    2006-07-01

    Due to the prevailing importance of the tracheal system for insect respiration, hemoglobins had been considered rare exceptions in this arthropod subphylum. Here we report the identification, cloning and expression analysis of a true hemoglobin gene in the honeybee Apis mellifera (Hymenoptera). The deduced amino acid sequence covers 171 residues (19.5kDa) and harbors all globin-typical features, including the proximal and the distal histidines. The protein has no signal peptide for transmembrane transport and was predicted to localize in the cytoplasm. The honeybee hemoglobin gene shows an ancient structure, with introns in positions B12.2 and G7.0, while most other insect globins have divergent intron positions. In situ hybridization studies showed that hemoglobin expression in the honeybee is mainly associated with the tracheal system. We also observe hemoglobin expression in the Malpighi tubes and testis. We further demonstrated that hemoglobins occur in other insect orders (Hemiptera, Coleoptera, Lepidoptera), suggesting that such genes belong to the standard repertoire of an insect genome. Phylogenetic analyses show that globins evolved along with the accepted insect systematics, with a remarkable diversification within the Diptera. Although insect hemoglobins may be in fact involved in oxygen metabolism, it remains uncertain whether they carry out a myoglobin-like function in oxygen storage and delivery. PMID:16698031

  3. Activity of telomerase and telomeric length in Apis mellifera.

    Science.gov (United States)

    Korandová, Michala; Frydrychová, Radmila Čapková

    2016-06-01

    Telomerase is an enzyme that adds repeats of DNA sequences to the ends of chromosomes, thereby preventing their shortening. Telomerase activity is associated with proliferative status of cells, organismal development, and aging. We report an analysis of telomerase activity and telomere length in the honeybee, Apis mellifera. Telomerase activity was found to be regulated in a development and caste-specific manner. During the development of somatic tissues of larval drones and workers, telomerase activity declined to 10 % of its level in embryos and remained low during pupal and adult stages but was upregulated in testes of late pupae, where it reached 70 % of the embryo level. Upregulation of telomerase activity was observed in the ovaries of late pupal queens, reaching 160 % of the level in embryos. Compared to workers and drones, queens displayed higher levels of telomerase activity. In the third larval instar of queens, telomerase activity reached the embryo level, and an enormous increase was observed in adult brains of queens, showing a 70-fold increase compared to a brain of an adult worker. Southern hybridization of terminal TTAGG fragments revealed a high variability of telomeric length between different individuals, although the same pattern of hybridization signals was observed in different tissues of each individual. PMID:26490169

  4. Overview of API research projects on thread compound performance properties

    International Nuclear Information System (INIS)

    Thread compounds are critical in achieving a leak-tight seal and for the prevention of connection damage during the make-up, running, and break-out of OCTG pipe. Over the last several years, there has been an increased awareness of the variance in thread compound performance properties and the need to evaluate the effect on field operational practices and to set compound selection criteria accordingly. These variances occur not only between different compound types, but also between compounds of the same general composition. Differences in performance properties are seen particularly in the new generation of proprietary compounds that have been developed to address the increasing environmental regulations and concerns that are effecting all segments of the industry. Full-scale testing of thread compounds either in Me field or the laboratory can be cost prohibitive and presents variables that are difficult or impossible to control This paper presents an overview of recent API research projects that have the objective of developing small-scale, standardized laboratory test procedures that can be used to determine relative performance properties, predict field performance, and be utilized for quality control both in the manufacture and purchasing of thread compounds

  5. Nosema Tolerant Honeybees (Apis mellifera Escape Parasitic Manipulation of Apoptosis.

    Directory of Open Access Journals (Sweden)

    Christoph Kurze

    Full Text Available Apoptosis is not only pivotal for development, but also for pathogen defence in multicellular organisms. Although numerous intracellular pathogens are known to interfere with the host's apoptotic machinery to overcome this defence, its importance for host-parasite coevolution has been neglected. We conducted three inoculation experiments to investigate in the apoptotic respond during infection with the intracellular gut pathogen Nosema ceranae, which is considered as potential global threat to the honeybee (Apis mellifera and other bee pollinators, in sensitive and tolerant honeybees. To explore apoptotic processes in the gut epithelium, we visualised apoptotic cells using TUNEL assays and measured the relative expression levels of subset of candidate genes involved in the apoptotic machinery using qPCR. Our results suggest that N. ceranae reduces apoptosis in sensitive honeybees by enhancing inhibitor of apoptosis protein-(iap-2 gene transcription. Interestingly, this seems not be the case in Nosema tolerant honeybees. We propose that these tolerant honeybees are able to escape the manipulation of apoptosis by N. ceranae, which may have evolved a mechanism to regulate an anti-apoptotic gene as key adaptation for improved host invasion.

  6. Tranų (apis mellifera l.) skraidymo ritmai

    OpenAIRE

    Katinienė, Aurelija

    2007-01-01

    2004 ir 2006 m. birželio – rugpjūčio mėn. buvo tiriama medunešių bičių (Apis mellifera L.) tranų skraidymo pradžia, tranų skraidymo dinamika dienos metu ir kokią įtaką jai daro aplinkos temperatūra. Įvertintas išskrendančių ir atskrendančių į tą pačią bičių šeimą tranų skaičius bei tranų skridimas į svetimas bi��ių šeimas. Ištirta 6 stipresnės ir 5 silpnesnės bičių šeimos. Buvo skaičiuojami per 2 min. iš avilio išskridę, po to per 2 min. į avilį atskridę tranai. Kiekvienos bičių šeimos tranai...

  7. When API Mass Spectrometry Meets Super Atmospheric Pressure Ion Sources.

    Science.gov (United States)

    Chen, Lee Chuin

    2015-01-01

    In a tutorial paper on the application of free-jet technique for API-MS, John Fenn mentioned that "…for a number of years and a number of reasons, it has been found advantageous in many situations to carry out the ionization process in gas at pressures up to 1000 Torr or more" (Int. J. Mass Spectrom. 200: 459-478, 2000). In fact, the first ESI mass spectrometer constructed by Yamashita and Fenn had a counter-flow curtain gas source at 1050 Torr (ca. 1.4 atm) to sweep away the neutral (J. Phys. Chem. 88: 4451-4459, 1984). For gaseous ionization using electrospray plume, theoretical analysis also shows that "super-atmospheric operation would be more preferable in space-charge-limited situations."(Int. J. Mass Spectrom. 300: 182-193, 2011). However, electrospray and the corona-based chemical ion source (APCI) in most commercial instrument are basically operated under an atmospheric pressure ambient, perhaps out of the concern of safety, convenience and simplicity in maintenance. Running the ion source at pressure much higher than 1 atm is not so common, but had been done by a number of groups as well as in our laboratory. A brief review on these ion sources will be given in this paper.

  8. Cytosine modifications in the honey bee (Apis mellifera) worker genome.

    Science.gov (United States)

    Rasmussen, Erik M K; Amdam, Gro V

    2015-01-01

    Epigenetic changes enable genomes to respond to changes in the environment, such as altered nutrition, activity, or social setting. Epigenetic modifications, thereby, provide a source of phenotypic plasticity in many species. The honey bee (Apis mellifera) uses nutritionally sensitive epigenetic control mechanisms in the development of the royal caste (queens) and the workers. The workers are functionally sterile females that can take on a range of distinct physiological and/or behavioral phenotypes in response to environmental changes. Honey bees have a wide repertoire of epigenetic mechanisms which, as in mammals, include cytosine methylation, hydroxymethylated cytosines, together with the enzymatic machinery responsible for these cytosine modifications. Current data suggests that honey bees provide an excellent system for studying the "social repertoire" of the epigenome. In this review, we elucidate what is known so far about the honey bee epigenome and its mechanisms. Our discussion includes what may distinguish honey bees from other model animals, how the epigenome can influence worker behavioral task separation, and how future studies can answer central questions about the role of the epigenome in social behavior. PMID:25705215

  9. Relatedness among honeybees (Apis mellifera) of a drone congregation

    Science.gov (United States)

    Baudry, E.; Solignac, M.; Garnery, L.; Gries, M.; Cornuet, J.-M.; Koeniger, N.

    1998-01-01

    The honeybee (Apis mellifera) queen mates during nuptial flights, in the so-called drone congregation area where many males from surrounding colonies gather. Using 20 highly polymorphic microsatellite loci, we studied a sample of 142 drones captured in a congregation close to Oberursel (Germany). A parentage test based on lod score showed that this sample contained one group of four brothers, six groups of three brothers, 20 groups of two brothers and 80 singletons. These values are very close to a Poisson distribution. Therefore, colonies were apparently equally represented in the drone congregation, and calculations showed that the congregation comprised males that originated from about 240 different colonies. This figure is surprisingly high. Considering the density of colonies around the congregation area and the average flight range of males, it suggests that most colonies within the recruitment perimeter delegated drones to the congregation with an equal probability, resulting in an almost perfect panmixis. Consequently, the relatedness between a queen and her mates, and hence the inbreeding coefficient of the progeny, should be minimized. The relatedness among the drones mated to the same queen is also very low, maximizing the genetic diversity among the different patrilines of a colony.

  10. Cytosine modifications in the honey bee (Apis mellifera worker genome

    Directory of Open Access Journals (Sweden)

    Erik Magne Koscielniak Rasmussen

    2015-02-01

    Full Text Available Epigenetic changes enable genomes to respond to changes in the environment, such as altered nutrition, activity, or social setting. Epigenetic modifications, thereby, provides a source of phenotypic plasticity in many species. The honey bee (Apis mellifera uses nutritionally sensitive epigenetic control mechanisms in the development of the royal caste (queens and the workers. The workers are functionally sterile females that can take on a range of distinct physiological and/or behavioral phenotypes in response to environmental changes. Honey bees have a wide repertoire of epigenetic mechanisms which, as in mammals, includes cytosine methylation, hydroxymethylated cytosines, together with the enzymatic machinery responsible for these cytosine modifications. Current data suggests that honey bees provide an excellent system for studying the social repertoire of the epigenome. In this review, we elucidate what is known so far about the honey bee epigenome and its mechanisms. Our discussion includes what may distinguish honey bees from other model animals, how the epigenome can influence worker behavioral task separation, and how future studies can answer central questions about the role of the epigenome in social behavior.

  11. Western honeybee drones and workers (Apis mellifera ligustica) have different olfactory mechanisms than eastern honeybees (Apis cerana cerana).

    Science.gov (United States)

    Woltedji, Dereje; Song, Feifei; Zhang, Lan; Gala, Alemayehu; Han, Bin; Feng, Mao; Fang, Yu; Li, Jianke

    2012-09-01

    The honeybees Apis mellifera ligustica (Aml) and Apis cerana cerana (Acc) are two different western and eastern bee species that evolved in distinct ecologies and developed specific antennal olfactory systems for their survival. Knowledge of how their antennal olfactory systems function in regards to the success of each respective bee species is scarce. We compared the antennal morphology and proteome between respective sexually mature drones and foraging workers of both species using a scanning electron microscope, two-dimensional electrophoresis, mass spectrometry, bioinformatics, and quantitative real-time polymerase chain reaction. Despite the general similarities in antennal morphology of the drone and worker bees between the two species, a total of 106 and 100 proteins altered their expression in the drones' and the workers' antennae, respectively. This suggests that the differences in the olfactory function of each respective bee are supported by the change of their proteome. Of the 106 proteins that altered their expression in the drones, 72 (68%) and 34 (32%) were overexpressed in the drones of Aml and Acc, respectively. The antennae of the Aml drones were built up by the highly expressed proteins that were involved in carbohydrate metabolism and energy production, molecular transporters, antioxidation, and fatty acid metabolism in contrast to the Acc drones. This is believed to enhance the antennal olfactory functions of the Aml drones as compared to the Acc drones during their mating flight. Likewise, of the 100 proteins with expression changes between the worker bees of the two species, 67% were expressed in higher levels in the antennae of Aml worker contrasting to 33% in the Acc worker. The overall higher expressions of proteins related to carbohydrate metabolism and energy production, molecular transporters, and antioxidation in the Aml workers compared with the Acc workers indicate the Aml workers require more antennal proteins for their olfactory

  12. SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms.

    Directory of Open Access Journals (Sweden)

    Zongyun Chen

    Full Text Available BACKGROUND: Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type subfamily, and whether there are other novel types of protease inhibitors in animal venom remains unclear. PRINCIPAL FINDINGS: Here, by screening scorpion venom gland cDNA libraries, we identified the first Ascaris-type animal toxin family, which contains four members: Scorpiops jendeki Ascaris-type protease inhibitor (SjAPI, Scorpiops jendeki Ascaris-type protease inhibitor 2 (SjAPI-2, Chaerilus tricostatus Ascaris-type protease inhibitor (CtAPI, and Buthus martensii Ascaris-type protease inhibitor (BmAPI. The detailed characterization of Ascaris-type peptide SjAPI from the venom gland of scorpion Scorpiops jendeki was carried out. The mature peptide of SjAPI contains 64 residues and possesses a classical Ascaris-type cysteine framework reticulated by five disulfide bridges, different from all known protease inhibitors from venomous animals. Enzyme and inhibitor reaction kinetics experiments showed that recombinant SjAPI was a dual function peptide with α-chymotrypsin- and elastase-inhibiting properties. Recombinant SjAPI inhibited α-chymotrypsin with a Ki of 97.1 nM and elastase with a Ki of 3.7 μM, respectively. Bioinformatics analyses and chimera experiments indicated that SjAPI contained the unique short side chain functional residues "AAV" and might be a useful template to produce new serine protease inhibitors. CONCLUSIONS/SIGNIFICANCE: To our knowledge, SjAPI is the first functionally characterized animal toxin peptide with an Ascaris-type fold. The structural and functional diversity of animal toxins with protease-inhibiting properties suggested that bioactive peptides from animal venom glands might be a new source of protease inhibitors, which will accelerate the

  13. Characterization and expression profiles of MaACS and MaACO genes from mulberry (Morus alba L.)%桑树MaACS和MaACO基因的鉴定和表达模式研究

    Institute of Scientific and Technical Information of China (English)

    Chang-ying LIU; Shu-mei HAN; Cheng LU; Mao-de YU; Rui-hua LÜ; Jun LI; Ai-chun ZHAO; Xi-ling WANG; Umuhoza DIANE; Xiao-hong WANG; Chuan-hong WANG; Ya-sheng YU

    2014-01-01

    1-Aminocyclopropane-1-carboxylic acid synthase (ACS) and 1-aminocyclopropane-1-carboxylic acid oxidase (ACO) are encoded by multigene families and are involved in fruit ripening by catalyzing the production of ethylene throughout the development of fruit. However, there are no reports on ACS or ACO genes in mulberry, partly because of the limited molecular research background. In this study, we have obtained five ACS gene sequences and two ACO gene sequences from Morus Genome Database. Sequence alignment and phylogenetic analysis of MaACO1 and MaACO2 showed that their amino acids are conserved compared with ACO proteins from other species. MaACS1 and MaACS2 are type I, MaACS3 and MaACS4 are type II, and MaACS5 is type III, with different C-terminal se-quences. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) expression analysis showed that the transcripts of MaACS genes were strongly expressed in fruit, and more weakly in other tissues. The expression of MaACO1 and MaACO2 showed different patterns in various mulberry tissues. MaACS and MaACO genes demon-strated two patterns throughout the development of mulberry fruit, and both of them were strongly up-regulated by abscisic acid (ABA) and ethephon.%研究目的:分离和鉴定桑树中参与乙烯生物合成的酶的编码基因MaACS 和MaACO,研究其表达模式。创新要点:基于最新公布的桑树基因组数据库数据,获得5个MaACS 基因和2个MaACO 基因,对其进行了生物信息分析,同时鉴定了其在不同桑树组织中、不同发育时期桑椹中和不同激素作用下的表达模式。研究方法:通过生物信息学方法筛选和鉴定基因,利用荧光定量逆转录聚合酶链式反应(qRT-PCR)分析基因的表达量。重要结论:MaACS 和MaACO 基因在根、茎、叶等不同组织中呈现出不同的表达模式,在桑椹发育过程中呈现出两种表达模式,其表达量被脱落酸和乙烯利上调。

  14. The construction of prokaryotic expression system for human Api6 fusion protein%人Api6融合蛋白原核表达系统的构建

    Institute of Scientific and Technical Information of China (English)

    方严; 练雪梅

    2011-01-01

    Objective:To further study the pathophysiological function of human Api6 fusion protein expression using a prokaryotic expression system. Methods: Api6 cDNA was inserted into ppSUMO vector to form recombinant plasmid pp-SUMO-Api6;recombinant plasmid ppSUMO-Api6 was trans-formed into prokaryotic expression host E.coli Rosetta;prokaryotic expression method was optimized to induce expression of recombi-nant protein Api6 in different conditions of E.coli density,temperature,IPTG concentration and induction time;recombinant protein Api6 was identified by Western blot. Results:The recombinant plasmid ppSUMO-Api6 was successfully constructed;the recombinant protein Api6 was successfully induced,and the expression of recombinant protein ppSUMO-Api6 from the prokaryotic expression system was optimized in the condition of OD600=0.5-0.8,16℃,0.5 mmol/L IPTG and 16 h induction.Conclusion:Recombinant plasmid ppSUMO-Api6 was converted into the prokaryotic expression host E.coli Rosetta to get the recombinant strain ppSUMO-Api6-Rosetta.Recombinant protein ppSUMO-Api6 was expressed using a prokaryotic expression system at the optimal expression conditions.%目的:本研究拟采用蛋白原核表达的方法,诱导表达人Api6(Apoptosis inhibitor 6)融合蛋白,为进一步研究Api6在凋亡抑制、脂质代谢和肿瘤发生中的作用奠定基础.方法:利用PCR技术扩增人Api6基因,将其克隆至原核表达载体ppSUMO,构建重组质粒ppSUMO-Api6;重组质粒转化原核表达宿主菌E.coli Rosetta感受态;采用蛋白原核表达的方法,不同诱导前菌液浓度,不同温度、不同异丙基硫化半乳糖苷(Isopropy 1-β-D-thiogalaotopyrano-side,IPTG)浓度、不同诱导时间,筛选诱导表达Api6重组蛋白的最优条件;Western blot鉴定其表达情况.结果:成功构建重组质粒ppSUMO-Api6;成功诱导Api6重组蛋白的原核表达,表达的最优条件为:OD600=0.5~0.8的重组菌,16℃、0.5 mmol/L IPTG诱导16 h.结论:含有人Api6 c

  15. First Detection of Nosema ceranae, a Microsporidian Protozoa of European Honey­bees (Apis mellifera) In Iran

    OpenAIRE

    Gerami Sadeghian, A; S Nabian; Ahmadi, K; MH Nazem Shirazi

    2011-01-01

    Background: Nosemosis of European honey bee (Apis mellifera) is present in bee colonies world­wide. Until recently, Nosema apis had been regarded as the causative agent of the disease, that causes heavy economic losses in apicultures. Nosema ceranae is an emerging microsporidian para­site of European honeybees, A. mellifera, but its distribution is not well known. Previously, nosemosis in honeybees in Iran was attributed exclusively to N. apis.Methods: Six Nosema positive samples (determined ...

  16. Comparison of API 20E and invA PCR for identification of Salmonella enterica isolates from swine production units.

    Science.gov (United States)

    Nucera, Daniele M; Maddox, Carol W; Hoien-Dalen, Patricia; Weigel, Ronald M

    2006-09-01

    API 20E and invA PCR were evaluated for the identification of Salmonella enterica isolates from swine farms. API 20E had the highest agreement with other tests at the 99.9% likelihood level. Both tests had 100% sensitivity and 96% specificity compared to 16S rRNA sequencing. Compared to serotyping, both tests had 96% sensitivity; specificity was 86% for API 20E and 79% for invA PCR.

  17. The Quality Management of Pipe Welding in Standard of API1104%API1104-2008标准中管道焊接质量管理

    Institute of Scientific and Technical Information of China (English)

    赵辉

    2011-01-01

    通过运用5M1E分析法,从人、机器、材料、方法、测量、环境六个方面对API 1104-2008进行分析,明确管道焊接时,API1104-2008在焊接操作者及检测人员、机械设备、管材、焊接材料、焊接工艺方法、焊缝检测以及工作环境等方面采取的质量管理控制措施。%Through the use of 5M1E analysis to specify quality control measures of welding operators,inspectors,mechanical equipments,steel tube,welding material,welding technology evaluation,appearance and nondestructive testing and working environment of API1104-2008,the thesis analyzes API1104-2008 from six aspects: man,machines,materials,methods,measurements,and environment.

  18. Qualidade de vida de pacientes submetidos ao transplante cardíaco: aplicação da escala Whoqol-Bref Calidad de vida de pacientes sometidos a transplante cardíaco: aplicación de la escala Whoqol-Bref Quality of life of patients that had a heart transplant: application of Whoqol-Bref scale

    Directory of Open Access Journals (Sweden)

    Maria Isis Freire de Aguiar

    2011-01-01

    Full Text Available FUNDAMENTO: O sucesso do transplante cardíaco significa garantir a sobrevida dos pacientes com cardiopatia e permitir-lhes desenvolver suas atividades diárias. O transplante cardíaco apresenta-se como a primeira opção de tratamento na falência cardíaca, representando um aumento de sobrevida e qualidade de vida dos transplantados. OBJETIVO: Avaliar a qualidade de vida de pacientes submetidos ao transplante cardíaco através da aplicação de uma escala padronizada (Whoqol-Bref. MÉTODOS: Estudo exploratório descritivo de abordagem quantitativa, realizado com 55 pacientes submetidos ao transplante cardíaco, em um período entre o terceiro e o 103º mês, que realizam acompanhamento na Unidade de Transplante e Insuficiência Cardíaca em um Hospital de Referência em Cardiologia na cidade de Fortaleza, CE. Os dados foram coletados no período de fevereiro a abril de 2009, por meio da aplicação de um questionário padronizado pela Organização Mundial da Saúde e utilização de dados constantes nos prontuários. RESULTADOS: Com relação ao domínio físico, 62,8% e 58,3% dos pacientes, dos sexos masculino e feminino, respectivamente, estão satisfeitos. No domínio psicológico, dentre pacientes do sexo masculino, 65,1% apresentam satisfação quanto à qualidade de vida e, no sexo feminino, 58,3% encontram-se satisfeitas. No domínio das relações sociais, observou-se que, no sexo masculino, 53,5% estão muito satisfeitos, e apresentou-se um nível de satisfação de 100% no sexo feminino. No domínio do meio ambiente, 65,1% do sexo masculino encontram-se satisfeitos, e no sexo feminino, 83,3% estão satisfeitas. CONCLUSÃO: O transplante cardíaco teve bastante influência na qualidade de vida dos pacientes transplantados, pois os resultados mostram-se estatisticamente significantes no pós-transplante.FUNDAMENTO: El éxito del transplante cardíaco significa garantizar la sobrevida de los pacientes con cardiopatía y permitirles

  19. Consistent evaluation of ACOS-GOSAT, BESD-SCIAMACHY, CarbonTracker, and MACC through comparisons to TCCON

    Science.gov (United States)

    Kulawik, Susan; Wunch, Debra; O'Dell, Christopher; Frankenberg, Christian; Reuter, Maximilian; Oda, Tomohiro; Chevallier, Frederic; Sherlock, Vanessa; Buchwitz, Michael; Osterman, Greg; Miller, Charles E.; Wennberg, Paul O.; Griffith, David; Morino, Isamu; Dubey, Manvendra K.; Deutscher, Nicholas M.; Notholt, Justus; Hase, Frank; Warneke, Thorsten; Sussmann, Ralf; Robinson, John; Strong, Kimberly; Schneider, Matthias; De Mazière, Martine; Shiomi, Kei; Feist, Dietrich G.; Iraci, Laura T.; Wolf, Joyce

    2016-02-01

    Consistent validation of satellite CO2 estimates is a prerequisite for using multiple satellite CO2 measurements for joint flux inversion, and for establishing an accurate long-term atmospheric CO2 data record. Harmonizing satellite CO2 measurements is particularly important since the differences in instruments, observing geometries, sampling strategies, etc. imbue different measurement characteristics in the various satellite CO2 data products. We focus on validating model and satellite observation attributes that impact flux estimates and CO2 assimilation, including accurate error estimates, correlated and random errors, overall biases, biases by season and latitude, the impact of coincidence criteria, validation of seasonal cycle phase and amplitude, yearly growth, and daily variability. We evaluate dry-air mole fraction (XCO2) for Greenhouse gases Observing SATellite (GOSAT) (Atmospheric CO2 Observations from Space, ACOS b3.5) and SCanning Imaging Absorption spectroMeter for Atmospheric CHartographY (SCIAMACHY) (Bremen Optimal Estimation DOAS, BESD v2.00.08) as well as the CarbonTracker (CT2013b) simulated CO2 mole fraction fields and the Monitoring Atmospheric Composition and Climate (MACC) CO2 inversion system (v13.1) and compare these to Total Carbon Column Observing Network (TCCON) observations (GGG2012/2014). We find standard deviations of 0.9, 0.9, 1.7, and 2.1 ppm vs. TCCON for CT2013b, MACC, GOSAT, and SCIAMACHY, respectively, with the single observation errors 1.9 and 0.9 times the predicted errors for GOSAT and SCIAMACHY, respectively. We quantify how satellite error drops with data averaging by interpreting according to error2 = a2 + b2/n (with n being the number of observations averaged, a the systematic (correlated) errors, and b the random (uncorrelated) errors). a and b are estimated by satellites, coincidence criteria, and hemisphere. Biases at individual stations have year-to-year variability of ˜ 0.3 ppm, with biases larger than the TCCON

  20. Development of API 5 CT grade P110 steel casing; Desenvolvimento de tubos casing API 5 CT grau P110

    Energy Technology Data Exchange (ETDEWEB)

    Kojima, Sergio Seijo; Roza, Juliana Espinossi

    2003-07-01

    This paper has as objective to discuss the results gotten in experiences carried through in industrial scale for the development of pipes class API 5CT P110 (1), with 244 mm of diameter and 12 mm of thickness. The pipes were welded longitudinally by process ERW (electric resistance welding) and submitted to quenching and tempering heat treatments. A C-Mn-Cr alloy with adequate quenching ability was used for the attainment of a martensite microstructure after quenching. The pipes at a temperature of 880 deg C were quenched in water and subsequently tempered at 515 deg C. The integrity of the weld region was evaluated through non destructive tests and flattening tests, Charpy impact tests and fracture toughness tests (CTOD). The pipes achieved the tension properties stipulated in the standard (yield strength bigger limit of 758 Mpa), and also the energy in the Charpy impact test (transversal), considering that the energy value obtained was 55 J (at 0 deg C) for base metal and 44 J in the weld metal. (author)

  1. 一种基于新型图模型的 API 推荐系统%APISynth:A New Graph-Based API Recommender System

    Institute of Scientific and Technical Information of China (English)

    吕晨; 姜伟; 虎嵩林

    2015-01-01

    对象实例化是软件工程类库复用中一个常见、复杂的问题.即根据已知源类型的对象,用户需要编写代码对目标类型进行实例化.研究人员提出了若干种 API 自动推荐系统辅助用户解决上述问题.然而这些系统不能同时兼顾准确率和查全率,因此在一定程度上影响了系统的实用性.该文提出了一种兼顾准确率和查全率,基于新型图模型的 API 推荐系统———APISynth.在查全率方面,APISynth 使用一个新颖的全局图模型来表达类库中所有的API 依赖关系和 API 历史使用信息.利用新的全局图模型具有的特殊 Tag 元素和可达性质以避免错误的 API 调用.在准确率方面,APISynth 首先将对象实例化问题建模为 Top-K 子图查询问题,然后设计一种新的支持 DAG 形式解的图搜索算法,避免了传统的最短路径图搜索算法导致的查不准问题.实验结果表明,与现有多种方法相比, APISynth 在准确率和查全率两方面均获得了较大提升.%How to perform object instantiation is a common and complex problem in reusing an existing library.In this problem,given the object of source type,users need to write code to instantiate the destination type.Recently,researchers have proposed a variety of related API automatic recommender systems to fulfill this problem.These systems can assist users to solve the above issue in some degree.However,it is very difficult for such systems to achieve both good recall and precision,which affects the usability.This paper presents APISynth,a new graph-based API recommender system.In order to improve the recall,APISynth utilizes a new global graph model to give a better representation for the API dependencies in the relevant class library,and to include API historical usage information in.A special tag element is added to the new graph together with a new reach ability property to avoid false invocation of APIs

  2. Myeloid-specific Expression of Api6/AIM/Spα Induces Systemic Inflammation and Adenocarcinoma in the Lung

    OpenAIRE

    Qu, Peng; Du, Hong; Li, Yuan; Yan, Cong

    2009-01-01

    In order to study the functional role of apoptosis inhibition of myeloid lineage cells in tumor formation, apoptosis inhibitor 6 (Api6/AIM/Spα) was overexpressed in a myeloid-specific c-fms-rtTA/(TetO)7-CMV-Api6 bitransgenic mouse model under the control of the c-fms promoter/intron 2. In this bitransgenic system, Api6-Flag fusion protein was expressed in myeloid lineage cells after doxycycline treatment. Induction of Api6 abnormally elevated levels of macrophages, neutrophils and dendritic c...

  3. Endovascular repair of an aorto-iliac aneurysm succeeded by kidney transplantation Tratamento endovascular de aneurisma aorto-ilíaco sucedido por transplante renal

    Directory of Open Access Journals (Sweden)

    Marcelo Bellini Dalio

    2010-09-01

    Full Text Available We present the case of aorto-iliac aneurysm in a patient with chronic renal failure requiring dialysis who were treated with an endovascular stent graft and, later on, submitted to kidney transplantation. A 53-year-old male with renal failure requiring dialysis presented with an asymptomatic abdominal aorto-iliac aneurysm measuring 5.0cm of diameter. He was treated with endovascular repair technique, being used an endoprosthesis Excluder®. After four months, he was successfully submitted to kidney transplantation (dead donor, with anastomosis of the graft renal artery in the external iliac artery distal to the endoprosthesis. The magnetic resonance imaging, carried out 30 days after the procedure, showed a good positioning of the endoprosthesis and adequate perfusion of the renal graft. In the follow-up, the patient presented improvement of nitrogenous waste, good positioning of the endoprosthesis without migration or endoleak. The endovascular repair of aorto-iliac aneurysm in a patient with end-stage renal failure under hemodialysis treatment showed to be feasible, safe and efficient, as it did not prevent the success of the posterior kidney transplantation.Apresentamos o caso de aneurisma aortoilíaco em um paciente com insuficiência renal crônica dialítica tratado com uma endoprótese vascular, sendo, após, submetido a transplante renal. Um homem de 53 anos com insuficiência renal dialítica apresentava um aneurisma abdominal aortoilíaco assintomático com 5,0cm de diâmetro. Foi tratado com técnica endovascular com uma endoprótese Excluderâ. Após quatro meses, foi submetido a transplante renal (doador cadáver com sucesso, com anastomose da artéria renal do enxerto na artéria ilíaca externa distal à endoprótese. A ressonância magnética 30 dias após o procedimento mostrou a endoprótese bem posicionada e o enxerto renal bem perfundido. No seguimento, o paciente evoluiu com melhora das escórias nitrogenadas, bom

  4. Transplante experimental cardíaco heterotópico e cutâneo em camundongos Experimental heterotopic cardiac and cutaneous transplantation in mice

    Directory of Open Access Journals (Sweden)

    Patrícia Sestrheim

    2005-06-01

    Full Text Available OBJETIVO: Estudo experimental com o objetivo de desenvolver e avaliar a viabilidade das técnicas de transplante experimental cardíaco heterotópico abdominal vascularizado e cutâneo em camundongos, criando um instrumento para investigação da eficácia de soluções de preservação, novas drogas imunossupressoras, agentes biológicos, terapia gênica e indução de tolerância imunológica. MÉTODO: Para este estudo, as técnicas utilizadas foram descritas previamente por Corry et al. e Billingham et al. RESULTADOS: O tempo cirúrgico total para a realização dos transplantes cardíacos (n=20 foi, em média, 60,3±6,3 minutos e para os transplantes cutâneos (n=20, 17,75±0,71 minutos. A média de sobrevida dos aloenxertos cutâneos (n=34 e cardíacos (n=24 foi, respectivamente, 7 e 11 dias, enquanto que os isoenxertos sobreviveram por mais de 100 dias. CONCLUSÕES: Ambas as técnicas se caracterizaram pela fácil reprodutibilidade dos modelos experimentais. As diferenças entre as técnicas não se limitaram às peculiaridades metodológicas ou ao tempo de sobrevida e vascularização, mas principalmente à sua imunogenicidade e suscetibilidade à rejeição.OBJECTIVE: This is an experimental study which aims at developing and evaluating the feasibility of experimental techniques of vascularized and cutaneous abdominal heterotopic heart transplant in mice, creating an instrument of investigation for the effectiveness of prservation solutions, new immunosuppressive drugs, biological agents, genetic therapy and induction of immunological tolerance. METHOD: The techniques used in this work were previously described by Corry et al. and Billingham et al. RESULTS: The total surgical time to perform the cardiac transplants (n=20 was on average 60.3+6.3 minutes and the time of cutaneous transplants (n= 20 17.75+0.71 minutes. The average survival of the cutaneous allografts (n=34 and cardiac (n=24 allografts was 7 and 11 days, respectively, while

  5. Tamponamento cardíaco tardio traumático: análise de cinco casos Traumatic late cardiac tamponade: analysis of five cases

    Directory of Open Access Journals (Sweden)

    FERNANDO LUIZ WESTPHAL

    2000-09-01

    Full Text Available São analisados cinco casos de tamponamento cardíaco tardio traumático. Os pacientes eram masculinos, idade média de 26,2 anos, vítimas de ferimento por arma branca em região precordial, área de Ziedler, sendo admitidos em centro de referência para trauma. Foram classificados pelo índice fisiológico de Ivatury para trauma cardíaco e inicialmente tratados por pleurotomia intercostal e reposição volêmica, com estabilização do quadro hemodinâmico e respiratório. Os pacientes foram readmitidos após intervalo de oito a 24 dias (mediana de 20 dias, agora no serviço de cirurgia torácica de um hospital de referência terciária, com sinais de tamponamento cardíaco. Os exames diagnósticos confirmaram derrame pericárdico com espessamento pericárdico associado a encarceramento de base pulmonar esquerdo em quatro casos, os quais foram abordados por toracotomia póstero-lateral, com realização de pericardiectomia parcial e descorticação pulmonar. Um paciente evoluiu com pericardite purulenta, comprovada por exames complementares, e foi submetido à drenagem pericárdica subxifóidea. Ocorreu arritmia pós-operatória em um paciente; os demais evoluíram sem complicações pós-operatórias ou recidiva do tamponamento.Five traumatic late cardiac tamponade cases were analyzed. All patients were male, mean age was 26.2, victims of thoracic penetrating stabbing wound in the precordial region, Ziedler area, admitted to a trauma reference center. They were classified by the Ivatury physiological index for cardiac trauma. The first treatment approach was intercostal pleurectomy and volemic resuscitation followed by hemodynamic and respiratory recovery. Patients with cardiac tamponade symptoms were re-admitted within an interval from eight to twenty four days (mean 20 days in a thoracic surgery service of a tertiary reference hospital. Diagnostic exams confirmed thickening and pericardial effusion associated with a left pulmonary base

  6. Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental

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    Julio E. Enders

    1995-02-01

    Full Text Available Experimental Chagas' disease (45 to 90 days post-infection showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase. Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control p Estudaram-se os receptores beta cardíacos de camundongos infectados pelo Trypanosoma cruzi na fase pós-aguda da doença de Chagas para estabelecer em que medida os mesmos contribuem a gerar respostas anômalas às catecolaminas observadas nestes miocardios. Utilizara-se 3-H/DHA para a marcação dos receptores beta cardíacos dos camundongos normais e dos infectados na fase pós-aguda (45 a 90 dias pós-infecção. O número dos sítios de fixação foi similar nos dois grupos, 78.591 ± 3.125 fmol/mg. Proteína nos chagásicos e 73.647 ± 2.194 fmol/mg. Proteína no grupo controle. Em vez disso, a afinidade verificou-se significativamente diminuida no grupo chagásico (Kd = 7.299 ± 0.426 nM respeito do controle (Kd = 3.759 ± 0.212 nM p < 0.001. Os resultados obtidos demonstram que as modificações observadas na estimulação adrenérgica do miocárdio chagásico se correlacionam com a menor afinidade dos receptores beta cardíacos e que estas alterações exerceriam uma parte determinante para as consequências funcionais que são detectadas na fase crônica.

  7. Do estigma da psicose maníaco-depressiva ao incentivo ao tratamento do transtorno bipolar: a evolução da abordagem em dois veículos midiáticos nos últimos 40 anos

    Directory of Open Access Journals (Sweden)

    Daniel Montanini

    2012-01-01

    Full Text Available OBJETIVO: Investigar a evolução ao longo dos últimos 40 anos da assimilação midiática do transtorno bipolar. MÉTODOS: Foram pesquisadas referências sobre os termos "transtorno bipolar" e "maníaco-depressivo" na revista Veja e no jornal The New York Times e analisada uma amostra de 40 textos de cada veículo. Os textos foram divididos em dois grupos, o primeiro reunindo aqueles datados dos anos entre 1970 e 1999 e o segundo, 2000 a 2009. RESULTADOS: Entre os anos de 1970 e 1999 é mais utilizado o termo "maníaco-depressivo", porém na década de 2000-2009 a expressão "transtorno bipolar" predomina amplamente. Além disso, artigos mais antigos, que utilizam principalmente o termo "maníaco-depressivo", tendem a ser mais estigmatizantes e com menor pretensão informativa. Já artigos mais recentes, em que a expressão "transtorno bipolar" é mais utilizada, tendem a incentivar a busca de tratamento. CONCLUSÃO: Sugere-se que a abordagem midiática do transtorno bipolar, comparada ao tratamento recebido pela psicose maníaco-depressiva, é marcada pela maior assimilação do referencial biomédico.

  8. Sperm use economy of honeybee (Apis mellifera) queens.

    Science.gov (United States)

    Baer, Boris; Collins, Jason; Maalaps, Kristiina; den Boer, Susanne P A

    2016-05-01

    The queens of eusocial ants, bees, and wasps only mate during a very brief period early in life to acquire and store a lifetime supply of sperm. As sperm cannot be replenished, queens have to be highly economic when using stored sperm to fertilize eggs, especially in species with large and long-lived colonies. However, queen fertility has not been studied in detail, so that we have little understanding of how economic sperm use is in different species, and whether queens are able to influence their sperm use. This is surprising given that sperm use is a key factor of eusocial life, as it determines the fecundity and longevity of queens and therefore colony fitness. We quantified the number of sperm that honeybee (Apis mellifera) queens use to fertilize eggs. We examined sperm use in naturally mated queens of different ages and in queens artificially inseminated with different volumes of semen. We found that queens are remarkably efficient and only use a median of 2 sperm per egg fertilization, with decreasing sperm use in older queens. The number of sperm in storage was always a significant predictor for the number of sperm used per fertilization, indicating that queens use a constant ratio of spermathecal fluid relative to total spermathecal volume of 2.364 × 10(-6) to fertilize eggs. This allowed us to calculate a lifetime fecundity for honeybee queens of around 1,500,000 fertilized eggs. Our data provide the first empirical evidence that honeybee queens do not manipulate sperm use, and fertilization failures in worker-destined eggs are therefore honest signals that workers can use to time queen replacement, which is crucial for colony performance and fitness. PMID:27217944

  9. Acaricide, fungicide and drug interactions in honey bees (Apis mellifera.

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    Reed M Johnson

    Full Text Available BACKGROUND: Chemical analysis shows that honey bees (Apis mellifera and hive products contain many pesticides derived from various sources. The most abundant pesticides are acaricides applied by beekeepers to control Varroa destructor. Beekeepers also apply antimicrobial drugs to control bacterial and microsporidial diseases. Fungicides may enter the hive when applied to nearby flowering crops. Acaricides, antimicrobial drugs and fungicides are not highly toxic to bees alone, but in combination there is potential for heightened toxicity due to interactive effects. METHODOLOGY/PRINCIPAL FINDINGS: Laboratory bioassays based on mortality rates in adult worker bees demonstrated interactive effects among acaricides, as well as between acaricides and antimicrobial drugs and between acaricides and fungicides. Toxicity of the acaricide tau-fluvalinate increased in combination with other acaricides and most other compounds tested (15 of 17 while amitraz toxicity was mostly unchanged (1 of 15. The sterol biosynthesis inhibiting (SBI fungicide prochloraz elevated the toxicity of the acaricides tau-fluvalinate, coumaphos and fenpyroximate, likely through inhibition of detoxicative cytochrome P450 monooxygenase activity. Four other SBI fungicides increased the toxicity of tau-fluvalinate in a dose-dependent manner, although possible evidence of P450 induction was observed at the lowest fungicide doses. Non-transitive interactions between some acaricides were observed. Sublethal amitraz pre-treatment increased the toxicity of the three P450-detoxified acaricides, but amitraz toxicity was not changed by sublethal treatment with the same three acaricides. A two-fold change in the toxicity of tau-fluvalinate was observed between years, suggesting a possible change in the genetic composition of the bees tested. CONCLUSIONS/SIGNIFICANCE: Interactions with acaricides in honey bees are similar to drug interactions in other animals in that P450-mediated detoxication

  10. Detection of Illicit Drugs by Trained Honeybees (Apis mellifera.

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    Matthias Schott

    Full Text Available Illegal drugs exacerbate global social challenges such as substance addiction, mental health issues and violent crime. Police and customs officials often rely on specially-trained sniffer dogs, which act as sensitive biological detectors to find concealed illegal drugs. However, the dog "alert" is no longer sufficient evidence to allow a search without a warrant or additional probable cause because cannabis has been legalized in two US states and is decriminalized in many others. Retraining dogs to recognize a narrower spectrum of drugs is difficult and training new dogs is time consuming, yet there are no analytical devices with the portability and sensitivity necessary to detect substance-specific chemical signatures. This means there is currently no substitute for sniffer dogs. Here we describe an insect screening procedure showing that the western honeybee (Apis mellifera can sense volatiles associated with pure samples of heroin and cocaine. We developed a portable electroantennographic device for the on-site measurement of volatile perception by these insects, and found a positive correlation between honeybee antennal responses and the concentration of specific drugs in test samples. Furthermore, we tested the ability of honeybees to learn the scent of heroin and trained them to show a reliable behavioral response in the presence of a highly-diluted scent of pure heroin. Trained honeybees could therefore be used to complement or replace the role of sniffer dogs as part of an automated drug detection system. Insects are highly sensitive to volatile compounds and provide an untapped resource for the development of biosensors. Automated conditioning as presented in this study could be developed as a platform for the practical detection of illicit drugs using insect-based sensors.

  11. Viruses associated with ovarian degeneration in Apis mellifera L. queens.

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    Laurent Gauthier

    Full Text Available Queen fecundity is a critical issue for the health of honeybee (Apis mellifera L. colonies, as she is the only reproductive female in the colony and responsible for the constant renewal of the worker bee population. Any factor affecting the queen's fecundity will stagnate colony development, increasing its susceptibility to opportunistic pathogens. We discovered a pathology affecting the ovaries, characterized by a yellow discoloration concentrated in the apex of the ovaries resulting from degenerative lesions in the follicles. In extreme cases, marked by intense discoloration, the majority of the ovarioles were affected and these cases were universally associated with egg-laying deficiencies in the queens. Microscopic examination of the degenerated follicles showed extensive paracrystal lattices of 30 nm icosahedral viral particles. A cDNA library from degenerated ovaries contained a high frequency of deformed wing virus (DWV and Varroa destructor virus 1 (VDV-1 sequences, two common and closely related honeybee Iflaviruses. These could also be identified by in situ hybridization in various parts of the ovary. A large-scale survey for 10 distinct honeybee viruses showed that DWV and VDV-1 were by far the most prevalent honeybee viruses in queen populations, with distinctly higher prevalence in mated queens (100% and 67%, respectively for DWV and VDV-1 than in virgin queens (37% and 0%, respectively. Since very high viral titres could be recorded in the ovaries and abdomens of both functional and deficient queens, no significant correlation could be made between viral titre and ovarian degeneration or egg-laying deficiency among the wider population of queens. Although our data suggest that DWV and VDV-1 have a role in extreme cases of ovarian degeneration, infection of the ovaries by these viruses does not necessarily result in ovarian degeneration, even at high titres, and additional factors are likely to be involved in this pathology.

  12. Detection of Illicit Drugs by Trained Honeybees (Apis mellifera).

    Science.gov (United States)

    Schott, Matthias; Klein, Birgit; Vilcinskas, Andreas

    2015-01-01

    Illegal drugs exacerbate global social challenges such as substance addiction, mental health issues and violent crime. Police and customs officials often rely on specially-trained sniffer dogs, which act as sensitive biological detectors to find concealed illegal drugs. However, the dog "alert" is no longer sufficient evidence to allow a search without a warrant or additional probable cause because cannabis has been legalized in two US states and is decriminalized in many others. Retraining dogs to recognize a narrower spectrum of drugs is difficult and training new dogs is time consuming, yet there are no analytical devices with the portability and sensitivity necessary to detect substance-specific chemical signatures. This means there is currently no substitute for sniffer dogs. Here we describe an insect screening procedure showing that the western honeybee (Apis mellifera) can sense volatiles associated with pure samples of heroin and cocaine. We developed a portable electroantennographic device for the on-site measurement of volatile perception by these insects, and found a positive correlation between honeybee antennal responses and the concentration of specific drugs in test samples. Furthermore, we tested the ability of honeybees to learn the scent of heroin and trained them to show a reliable behavioral response in the presence of a highly-diluted scent of pure heroin. Trained honeybees could therefore be used to complement or replace the role of sniffer dogs as part of an automated drug detection system. Insects are highly sensitive to volatile compounds and provide an untapped resource for the development of biosensors. Automated conditioning as presented in this study could be developed as a platform for the practical detection of illicit drugs using insect-based sensors. PMID:26083377

  13. Transcriptome analysis of the Asian honey bee Apis cerana cerana.

    Directory of Open Access Journals (Sweden)

    Zi Long Wang

    Full Text Available BACKGROUND: The Eastern hive honey bee, Apis cerana cerana is a native and widely bred honey bee species in China. Molecular biology research about this honey bee species is scarce, and genomic information for A. c. cerana is not currently available. Transcriptome and expression profiling data for this species are therefore important resources needed to better understand the biological mechanisms of A. c. cerana. In this study, we obtained the transcriptome information of A. c. cerana by RNA-sequencing and compared gene expression differences between queens and workers of A. c. cerana by digital gene expression (DGE analysis. RESULTS: Using high-throughput Illumina RNA sequencing we obtained 51,581,510 clean reads corresponding to 4.64 Gb total nucleotides from a single run. These reads were assembled into 46,999 unigenes with a mean length of 676 bp. Based on a sequence similarity search against the five public databases (NR, Swissport, GO, COG, KEGG with a cut-off E-value of 10(-5 using BLASTX, a total of 24,630 unigenes were annotated with gene descriptions, gene ontology terms, or metabolic pathways. Using these transcriptome data as references we analyzed the gene expression differences between the queens and workers of A. c. cerana using a tag-based digital gene expression method. We obtained 5.96 and 5.66 million clean tags from the queen and worker samples, respectively. A total of 414 genes were differentially expressed between them, with 189 up-regulated and 225 down-regulated in queens. CONCLUSIONS: Our transcriptome data provide a comprehensive sequence resource for future A. c. cerana study, establishing an important public information platform for functional genomic studies in A. c. cerana. Furthermore, the DGE data provide comprehensive gene expression information for the queens and workers, which will facilitate our understanding of the molecular mechanisms of the different physiological aspects of the two castes.

  14. 改进的牵引移动的蚁群算法在2D HP 模型中的应用%APPLYING IMPROVED PULL MOVES ACO IN 2D HP MODEL

    Institute of Scientific and Technical Information of China (English)

    高翔; 杨惠; 张成文

    2015-01-01

    Protein folding problem is to predict a protein’s conformation from its amino acid sequence,it is one of the most prominent problems in bioinformatics.In this paper we mainly study two-dimensional (2D)hydrophobic-polar (HP)lattice model,which is a representative simplified model widely used for simulating the protein folding problem,and apply the ant colony optimisation (ACO)to solving the 2D HP protein folding problem.Besides,we introduce an improved pull moves method to local search mechanism,to improve protein’s conformation it is an effective method.Experimental results show that the improved ACO with pull moves (ACO +)can obtain lower-energy conformations than ACO for several longer amino acid sequences,this demonstrates that our ACO + algorithm is a effective method to predict the structure of protein.%蛋白质折叠问题就是从氨基酸序列中预测蛋白质的构象,该问题是生物信息学的一个突出问题。主要研究二维 HP 格点模型,它是用于模拟蛋白质折叠问题的一个具有代表性的简化模型,并且将蚁群算法用于求解该二维 HP 蛋白质的折叠问题。此外,在局部搜索机制中引入一种改进的牵引移动方法,这是一个提高蛋白质构象的有效方法。实验结果表明,针对较长的氨基酸序列,改进的带牵引移动的蚁群算法(ACO +)比 ACO 能够获得更低能量的构象,证明了所提出的改进蚁群算法是预测蛋白质结构的有效方法。

  15. An Effective Method for Protecting Native API Hook Attacks in User-mode

    Directory of Open Access Journals (Sweden)

    K. Muthumanickam

    2015-01-01

    Full Text Available Today, many modern malware developers is taking the advantage of Application Programming Interface (API hook technique to take the control of the victim computer which making it difficult to detect their presence. Because of the sophistication of rootkit tools, a remote attacker can use native API to compromise any computer which can later be used for many illegal activities such as sniffing network lines, capturing passwords, sending spam and DDoS attack, etc. Thus to protect end-system by identifying and preventing native API malicious code hooking is a challenging problem to the defenders. Today, many different malware-analysis tools incur specific features against malwares but manual and error-prone. In this study, we proposed a behavior-based monitoring detection system to effectively deal native API hooks in user-mode. Unlike other malware identification techniques, our approach involved dynamically analyzing the behavior of native API call hooking malwares. Comparing our experimental evaluation results with existing tools show better performance with no false positive.

  16. Bioimpedância transtorácica comparada à ressonância magnética na avaliação do débito cardíaco

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    Humberto Villacorta Junior

    2012-12-01

    Full Text Available FUNDAMENTO: A ressonância magnética cardíaca é considerada o método padrão-ouro para o cálculo de volumes cardíacos. A bioimpedância transtorácica cardíaca avalia o débito cardíaco. Não há trabalhos que validem essa medida comparada à ressonância. OBJETIVO: Avaliar o desempenho da bioimpedância transtorácica cardíaca no cálculo do débito cardíaco, índice cardíaco e volume sistólico, utilizando a ressonância como padrão-ouro. MÉTODOS: Avaliados 31 pacientes, com média de idade de 56,7 ± 18 anos, sendo 18 (58% do sexo masculino. Foram excluídos os pacientes cuja indicação para a ressonância magnética cardíaca incluía avaliação sob estresse farmacológico. A correlação entre os métodos foi avaliada pelo coeficiente de Pearson, e a dispersão das diferenças absolutas em relação à média foi demonstrada pelo método de Bland-Altman. A concordância entre os métodos foi realizada pelo coeficiente de correlação intraclasses. RESULTADOS: A média do débito cardíaco pela bioimpedância transtorácica cardíaca e pela ressonância foi, respectivamente, 5,16 ± 0,9 e 5,13 ± 0,9 L/min. Observou-se boa correlação entre os métodos para o débito cardíaco (r = 0,79; p = 0,0001, índice cardíaco (r = 0,74; p = 0,0001 e volume sistólico (r = 0,88; p = 0,0001. A avaliação pelo gráfico de Bland-Altman mostrou pequena dispersão das diferenças em relação à média, com baixa amplitude dos intervalos de concordância. Houve boa concordância entre os dois métodos quando avaliados pelo coeficiente de correlação intraclasses, com coeficientes para débito cardíaco, índice cardíaco e volume sistólico de 0,78, 0,73 e 0,88, respectivamente (p < 0,0001 para todas as comparações. CONCLUSÃO: A bioimpedância transtorácica cardíaca mostrou-se acurada no cálculo do débito cardíaco quando comparada à ressonância magnética cardíaca.

  17. Confección de diagramas termodinámicos asociados a la mixtura amoníaco-agua en la fase líquido-vapor

    OpenAIRE

    Napoleão, Diovana Aparecida dos Santos; Silveira, Jose Luz; Reto, Alonso Bernabé Aguirre

    2006-01-01

    El objetivo de este trabajo es determinar la entalpía y la entropía relacionadas a un sistema de refrigeración por absorción, empleando mixturas de amoníaco y agua. El conocimiento de la termodinámica de mezclas, así como la utilización de los diagramas de entalpía-concentración y entropía-concentración son fundamentales para comprender el funcionamiento de los sistemas de refrigeración por absorción. Para proyectos industriales que signifiquen análisis energéticos y exergéticos, si...

  18. Efecto de la incorporación de fibras dietéticas en la calidad de panes para celíacos

    OpenAIRE

    Díaz Malmierca, Álvaro

    2013-01-01

    La investigación en la elaboración de panes sin gluten está muy avanzada, siendo el déficit en micronutrientes de estos productos uno de los problemas sobre el que se está centrando la investigación. Uno de los nutrientes más deficitarios, y que más problemas causa sobre la salud de los pacientes celíacos es la fibra dietética. En este estudio se ha investigado el efecto que produce la adición de un 10% de diferentes fibras sobre las características de los panes, la influencia ...

  19. Investigação de lipofuscina em miócitos cardíacos de camundongos após tratamento com oxamniquine

    Directory of Open Access Journals (Sweden)

    Maria Luiza Silveira Mello

    1984-10-01

    Full Text Available A fluorescencia natural devida à presença de corpos de lipofuscina foi pesquisada em miócitos cardíacos de camundongos adultos jovens tratados com oxamniquine. O objetivo foi buscar uma evidência de indução de envelhecimento celular precoce, com base em dados prévios de acentuação poliploidia, promovida pela droga. Comparando o miocárdio dos camundongos tratados com animais contrôle jovens e velhos, não foi observada a presença de lipofuscina nos seus miócitos. Isto possivelmente se deva a um não comprometimento da eficiência das lipases lisossomiais apesar da acentuação do fenômeno de poliploidização induzida pela droga.

  20. Characterization of the N-glycans of recombinant bee venom hyaluronidase (Api m 2) expressed in insect cells.

    Science.gov (United States)

    Soldatova, Lyudmila N; Tsai, Chaoming; Dobrovolskaia, Ekaterina; Marković-Housley, Zora; Slater, Jay E

    2007-01-01

    Honeybee venom hyaluronidase (Api m 2) is a major glycoprotein allergen. Previous studies have indicated that recombinant Api m 2 expressed in insect cells has enzyme activity and IgE binding comparable with that of native Api m 2. In contrast, Api m 2 expressed in Escherichia coli does not. In this study, we characterized the carbohydrate side chains of Api m 2 expressed in insect cells, and compared our data with the established carbohydrate structure of native Api m 2. We assessed both the monosaccharide and the oligosaccharide content of recombinant Api m 2 using fluorophore-assisted carbohydrate electrophoresis and HPLC. To identify the amino acid residues at which glycosylation occurs, we digested recombinant Api m 2 with endoproteinase Glu-C and identified the fragments that contained carbohydrate by specific staining. Recombinant Api m 2 expressed in insect cells contains N-acetylglucosamine, mannose, and fucose, as well as trace amounts of glucose and galactose, and the oligosaccharide analysis is consistent with heterogeneous oligosaccharide chains consisting of two to seven monosaccharides. No sialic acid or N-acetylgalactosamine were detected. These results are similar to published data for native Api m 2, although some monosaccharide components appear to be absent in the recombinant protein. Analysis of proteolytic digests indicates that of the four candidate N-glycosylation sites, carbohydrate chains are attached at asparagines 115 and 263. Recombinant Api m 2 expressed in insect cells has enzymic activity and IgE binding comparable with the native protein, and its carbohydrate composition is very similar. PMID:17479607

  1. Produtos naturais no comportamento defensivo de Apis mellifera L. = Natural products in the defensive behaviour of Apis mellifera L.

    Directory of Open Access Journals (Sweden)

    Renata Leonardo Lomele

    2010-07-01

    Full Text Available Os objetivos do estudo foram investigar a influência de produtos naturais como capim-limão (Cymbopogon citratus, folhas de abacateiro (Persea americana, casca de café (Coffea arabica e sementes de mamona (Ricinus communis na defensividade de Apis mellifera, e avaliar o efeito destes produtos no desenvolvimento populacional da colmeia. O comportamento defensivo foi avaliado por meio do tempo da primeira ferroada (TPF, número de ferrões (NFB e, o desenvolvimento populacional, pela área de cria aberta e fechada. Observou-se que o tratamento fumaça + sete sementes de mamona apresentou aumento significativo no TPF, em relação ao tratamento sem e com fumaça de maravalha. Com relação ao NFB, verificou-se que os tratamentos fumaça de maravalha + sete sementes de mamona e fumaça de maravalha + 20% de folhas de café foram diferentes do tratamento sem e com fumaça. Os demais tratamentos não diferiram significativamente em relação ao uso da fumaça ou sua ausência. A casca de café e a semente de mamona nãointerferiram no desenvolvimento populacional, sugerindo que estes compostos não foram tóxicos. Pode-se concluir que o uso de sementes de mamona e casca de café na fumaça pode representar importante ferramenta para a redução da defensividade, sem promover toxicidade para A. mellifera.The goal was to investigate the influence of natural products such as lemongrass (Cymbopogon citratus, dried avocado leaves (Persea americana, coffee husk (Coffea arabica and castor bean (Ricinus communis in the defense of Apis mellifera, as well the effect of these products on the population development of the beehive. Defensive behavior was evaluated by time of first sting (TFS and number of stingers (NS, and population development, by open brood area and operculated brood. It was observed that the treatment with smoke + seven castor beans presented significant increase in the TFS, for treatment without and with smoke. Regarding NS, it was verified

  2. A method for colocating satellite XCO2 data to ground-based data and its application to ACOS-GOSAT and TCCON

    Directory of Open Access Journals (Sweden)

    H. Nguyen

    2014-02-01

    Full Text Available Satellite measurements are often compared with higher-precision ground-based measurements as part of validation efforts. The satellite soundings are rarely perfectly coincident in space and time with the ground-based measurements, so a colocation methodology is needed to aggregate "nearby" soundings into what the instrument would have seen at the location and time of interest. We are particularly interested in validation efforts for satellite-retrieved total column carbon dioxide (XCO2, where XCO2 data from Greenhouse Gas Observing Satellite (GOSAT retrievals (ACOS, NIES, RemoteC, PPDF, etc. or SCanning Imaging Absorption SpectroMeter for Atmospheric CHartographY (SCHIACHY are often colocated and compared to ground-based column XCO2 measurement from Total Carbon Column Observing Network (TCCON. Current colocation methodologies for comparing satellite measurements of total column dry-air mole fractions of CO2 (XCO2 with ground-based measurements typically involve locating and averaging the satellite measurements within some latitudinal, longitudinal, and temporal window. We examine a geostatistical colocation methodology that takes a weighted average of satellite observations depending on the "distance" of each observation from a ground-based location of interest. The "distance" function that we use is a modified Euclidian distance with respect to latitude, longitude, time, and mid-tropospheric temperature at 700 hPa. We apply this methodology to XCO2 retrieved from Greenhouse Gas Observing Satellite (GOSAT spectra by the ACOS team, cross-validate the results to TCCON XCO2 ground-based data, and present some comparison between our methodology and standard existing colocation methods showing that in general geostatistical colocation produces smaller mean-squared error.

  3. Cerebral physiology and preservation during cardiac arrest Fisiología y preservación cerebral durante el paro cardíaco: vulnerabilidad del cerebro

    Directory of Open Access Journals (Sweden)

    Luis M. Gómez

    1991-03-01

    Full Text Available

    Cerebral physiology during cardiac arrest is discussed with particular Interest on selective neuronal damage. Previous concepts on brain tolerance to hypoxia are analyzed and new information about brain function prognosis after cardiac arrest is presented. Therapeutic alternatives for brain preservation are discussed with emphasis on the lack of effectiveness of barbiturates, the results of research with other drugs and the future role that blockers of excitatory neurotransmission may have as elements of cerebral preservation.

    Se hace una aproximación a la fisiología cerebral durante el paro cardíaco, destacando el concepto de darlo neuronal selectivo. Se presentan elementos que permiten modificar concepciones antiguas sobre la tolerancia del cerebro a la hipoxia severa. Además, se hace un nuevo planteamiento sobre el pronóstico cerebral luego de un paro cardíaco y se esbozan las alternativas terapéuticas utilizadas hasta la fecha para la preservación cerebral. Se hace énfasis en la inefectividad de los barbitúricos, en la investigación sobre la terapia con otras drogas y en el futuro abierto hacia los bloqueadores de los neurotransmisores excitadores, como elementos terapéuticos para la preservación cerebral.

  4. Using the RxNorm web services API for quality assurance purposes.

    Science.gov (United States)

    Peters, Lee; Bodenreider, Olivier

    2008-01-01

    Auditing large, rapidly evolving terminological systems is still a challenge. In the case of RxNorm, a standardized nomenclature for clinical drugs, we argue that quality assurance processes can benefit from the recently released application programming interface (API) provided by RxNav. We demonstrate the usefulness of the API by performing a systematic comparison of alternative paths in the RxNorm graph, over several thousands of drug entities. This study revealed potential errors in RxNorm, currently under review. The results also prompted us to modify the implementation of RxNav to navigate the RxNorm graph more accurately. The RxNav web services API used in this experiment is robust and fast. PMID:18999038

  5. The Design and Implementation of Cryptographic API%加密API的设计与实现

    Institute of Scientific and Technical Information of China (English)

    王军

    2004-01-01

    文章设计了一种简单易用、可扩展和可移植的加密API,简称SEPC-API.SEPC-API采用标准的C/C++来编写,并使用抽象密钥类分层结构来构造.文中详细描述了SEPC-API的设计和实现,并给出了应用示例.此外,SEPC-API中的多数函数设计遵循微软Crypto API的语法,这意味着微软Crypto API用户只需修改很少的代码就可以移植到SEPC-API.

  6. An API for Integrating Spatial Context Models with Spatial Reasoning Algorithms

    DEFF Research Database (Denmark)

    Kjærgaard, Mikkel Baun

    2006-01-01

    The integration of context-aware applications with spatial context models is often done using a common query language. However, algorithms that estimate and reason about spatial context information can benefit from a tighter integration. An object-oriented API makes such integration possible...... and can help reduce the complexity of algorithms making them easier to maintain and develop. This paper propose an object-oriented API for context models of the physical environment and extensions to a location modeling approach called geometric space trees for it to provide adequate support for location...... modeling. The utility of the API is evaluated in several real-world cases from an indoor location system, and spans several types of spatial reasoning algorithms....

  7. The SEMAINE API: Towards a Standards-Based Framework for Building Emotion-Oriented Systems

    Directory of Open Access Journals (Sweden)

    Marc Schröder

    2010-01-01

    Full Text Available This paper presents the SEMAINE API, an open source framework for building emotion-oriented systems. By encouraging and simplifying the use of standard representation formats, the framework aims to contribute to interoperability and reuse of system components in the research community. By providing a Java and C++ wrapper around a message-oriented middleware, the API makes it easy to integrate components running on different operating systems and written in different programming languages. The SEMAINE system 1.0 is presented as an example of a full-scale system built on top of the SEMAINE API. Three small example systems are described in detail to illustrate how integration between existing and new components is realised with minimal effort.

  8. Informacijos apie knygą elektroniniai šaltiniai Lietuvoje ir Didžiojoje Britanijoje

    OpenAIRE

    Smičiūtė, Sigita

    2012-01-01

    Magistro darbo objektas – Lietuvos ir Didžiosios Britanijos elektroniniai šaltiniai ir juose publikuojama informacija apie išleistas knygas. Darbo tikslas – išnagrinėti informaciją apie išleistas knygas elektroniniuose šaltiniuose, įvertinti ją ir palyginti probleminiu aspektu. Darbo uždaviniai: aptarti šiuolaikinę knygų rinkos situaciją, būdingą Lietuvai ir Didžiajai Britanijai; apibrėžti elektroninių informacijos šaltinių sampratą; suskirstyti į grupes ir ištirti informacijos apie knygas el...

  9. Studi Eksperimen Distribusi Temperatur Nyala Api Kompor Bioetanol Tipe Side Burner dengan Variasi Diameter Firewall

    Directory of Open Access Journals (Sweden)

    R.R. Vienna Sona Saputri Soetadi

    2012-09-01

    Full Text Available Untuk mendapatkan kompor bioetanol efisiensi thermal maksimal diperlukan penelitian komprehensif. Salah satunya adalah penelitian terhadap posisi peletakkan beban pada kompor bioetanol kompak. Pengujian dilakukan pada kompor uji bioetanol dengan kadar 99%, yaitu kompor bioetanol tipe side burner dengan firewall 2.5 inci dan firewall 3 inci. Pengukuran temperatur api dengan 13 thermocouple K dengan pengukuran searah api keatas setiap 5 mm-an. Kemudian, water boiling test dilakukan untuk mendapatkan daya dan beban dan dilanjutkan mengukur waktu pendidihan air. Hasil penelitian ini menunjukkan gambaran total distribusi temperatur nyala api difusi. Hasil menunjukkan untuk kompor 2.5 inci dengan daya 1.6 kW mempunyai temperatur 542 ºC dengan jarak ketinggian 5 mm dari rim kompor sedangkan kompor 3 inci menghasilkan daya 2.38 kW dengan temperatur 516 ºC.

  10. 360-MAM-Affect: Sentiment Analysis with the Google Prediction API and EmoSenticNet

    Directory of Open Access Journals (Sweden)

    Eleanor Mulholland

    2015-08-01

    Full Text Available Online recommender systems are useful for media asset management where they select the best content from a set of media assets. We have developed an architecture for 360-MAM- Select, a recommender system for educational video content. 360-MAM-Select will utilise sentiment analysis and gamification techniques for the recommendation of media assets. 360-MAM-Select will increase user participation with digital content through improved video recommendations. Here, we discuss the architecture of 360-MAM-Select and the use of the Google Prediction API and EmoSenticNet for 360-MAM-Affect, 360-MAM-Select's sentiment analysis module. Results from testing two models for sentiment analysis, Sentiment Classifier (Google Prediction API and EmoSenticNetClassifer (Google Prediction API + EmoSenticNet are promising. Future work includes the implementation and testing of 360-MAM-Select on video data from YouTube EDU and Head Squeeze.

  11. AN OVERVIEW OF THE UNCERTAINTY ANALYSIS, SENSITIVITY ANALYSIS, AND PARAMETER ESTIMATION (UA/SA/PE) API AND HOW TO IMPLEMENT IT

    Science.gov (United States)

    The Application Programming Interface (API) for Uncertainty Analysis, Sensitivity Analysis, andParameter Estimation (UA/SA/PE API) (also known as Calibration, Optimization and Sensitivity and Uncertainty (CUSO)) was developed in a joint effort between several members of both ...

  12. An overview of the CellML API and its implementation

    Directory of Open Access Journals (Sweden)

    Halstead Matt

    2010-04-01

    Full Text Available Abstract Background CellML is an XML based language for representing mathematical models, in a machine-independent form which is suitable for their exchange between different authors, and for archival in a model repository. Allowing for the exchange and archival of models in a computer readable form is a key strategic goal in bioinformatics, because of the associated improvements in scientific record accuracy, the faster iterative process of scientific development, and the ability to combine models into large integrative models. However, for CellML models to be useful, tools which can process them correctly are needed. Due to some of the more complex features present in CellML models, such as imports, developing code ab initio to correctly process models can be an onerous task. For this reason, there is a clear and pressing need for an application programming interface (API, and a good implementation of that API, upon which tools can base their support for CellML. Results We developed an API which allows the information in CellML models to be retrieved and/or modified. We also developed a series of optional extension APIs, for tasks such as simplifying the handling of connections between variables, dealing with physical units, validating models, and translating models into different procedural languages. We have also provided a Free/Open Source implementation of this application programming interface, optimised to achieve good performance. Conclusions Tools have been developed using the API which are mature enough for widespread use. The API has the potential to accelerate the development of additional tools capable of processing CellML, and ultimately lead to an increased level of sharing of mathematical model descriptions.

  13. Morphological, molecular, and phylogenetic characterization of Nosema cerana, a microsporidian parasite isolated from the European honey bee, Apis mellifera

    Science.gov (United States)

    Nosema ceranae, a microsporidian parasite originally described from Apis cerana, has been found to infect Apis melllifera and is highly pathogenic to its new host. In the present study, data on N. ceranae ultrastructure, host tissue tropism, secondary structures of ribosomal RNA, and phylogenetic ...

  14. Genomic survey of the ectoparasitic mite Varroa destructor, a major pest of the honey bee Apis mellifera

    OpenAIRE

    Elsik Chris; Bourgeois Lanie; Hunt Greg; Pettis Jeff; Chen Yan-Ping; Johnston Spencer J; Schatz Michael C; Cornman Scott R; Anderson Denis; Grozinger Christina M; Evans Jay D

    2010-01-01

    Background: The ectoparasitic mite Varroa destructor has emerged as the primary pest of domestic honey bees (Apis mellifera). Here we present an initial survey of the V. destructor genome carried out to advance our understanding of Varroa biology and to identify new avenues for mite control. This sequence survey provides immediate resources for molecular and population-genetic analyses of Varroa-Apis interactions ...

  15. Testing of the structure of macromolecular polymer films containing solid active pharmaceutical ingredient (API) particles

    Science.gov (United States)

    Bölcskei, É.; Süvegh, K.; Marek, T.; Regdon, G.; Pintye-Hódi, K.

    2011-07-01

    The aim of the present study was to investigate the structure of free films of Eudragit ® L 30D-55 containing different concentrations (0%, 1% or 5%) of diclofenac sodium by positron annihilation spectroscopy. The data revealed that the size of the free-volume holes and the lifetimes of ortho-positronium atoms decreased with increase of the API concentration. Films containing 5% of the API exhibited a different behavior during storage (17 °C, 65% relative humidity (RH)) in consequence of the uptake of water from the air.

  16. An API to Wi-Fi Direct Using Reactive Building Blocks

    OpenAIRE

    Gabrielsen, Erlend Bjerke

    2012-01-01

    Implementing unfamiliar functionalities in smartphone applications can be a difficult and a tedious task. Owing to the fact that the API do not have a formal way of representing the sequence of events may be one reason. This thesis describes the development process of various Arctis building blocks based on Android's API of Wi-Fi Direct. The objective of these blocks was to simplify the implementation of Wi-Fi Direct by confining a predictable sequence of events.An Android application wa...

  17. Atmospheric sulphuric acid and neutral cluster measurements using CI-APi-TOF

    OpenAIRE

    Jokinen, T; Sipilä, M.; Junninen, H.; M. Ehn; Lönn, G.; Hakala, J.; T. Petäjä; Mauldin, R. L.; M. Kulmala; Worsnop, D.R.

    2012-01-01

    The first ambient measurements using nitrate ion based Chemical Ionization with the Atmospheric Pressure interface Time-Of-Flight mass spectrometer (CI-APi-TOF) for sulphuric acid and neutral cluster detection are presented. We have found CI-APi-TOF a highly stable and sensitive tool for molecular sulphuric acid detection. The lowest limit of detection for sulphuric acid was determined to be 3.6 × 104 molecules cm−3 for 15 min averaging. Signals f...

  18. Application of OSN in membrane cascade for purification of the API Amoxicillin

    OpenAIRE

    Ferreira, Susana Cristina Dias Ramos

    2013-01-01

    Dissertação para obtenção do Grau de Mestre em Engenharia Química e Bioquímica The present work developed at Imperial College London (ICL) in collaboration with the Massachusetts Institute of Technology (MIT) had the objective of purifying the API amoxicillin containing an initial concentration of 30ppm of the compound 4-hydroxy-l-phenylglycine (impurity) using an OSN membrane cascade. Project proposal:  Solubility and stability studies of the API in different solvents.  Solv...

  19. Heterosis en la longevidad de obreras Apis mielífera

    Directory of Open Access Journals (Sweden)

    Soares AE.

    2001-06-01

    Full Text Available Se estimó la media y la heterosis de la longevidad en obreras de abejas Apis mellifera. El expe-rimento fue desarrollado en el Apiario del Departamento de Genética de la Facultad de Medi-cina de la USP-Ribeirão Preto-Brasil y en Jaboticabal-SP, de 03/1997 a 05/1999. Seleccionamos 8 matrices inseminadas del apiário-USP (2africanizadas, 2italianas, 2cárnicasy 2italianas*cárnicos y 2 matrices (grupo-testigo de abejas Africanizadas-Silvestres.

  20. Oriental orchid (Cymbidium pumilum) attracts drones of the Japanese honeybee (Apis cerana japonica) as pollinators.

    Science.gov (United States)

    Sasaki, M; Ono, M; Asada, S; Yoshida, T

    1991-12-01

    The discovery that drones of the Japanese honeybee (Apis cerana japonica) pollinate the oriental orchid (Cymbidium pumilum) is reported. Drones are attracted to the orchid flower aroma mainly during their mating flights in April through May. Some drones cluster on the flower racemes and others insert their heads deep into the flowers. Drones with pollinia on their scutellum visit other orchids, which facilitates pollination. Individual workers and swarming colonies are also strongly attracted by the flower aroma, but the allopatric western honeybee (Apis mellifera) is not attracted.

  1. Overview of soil and groundwater research activities of the American Petroleum Institute (API)

    International Nuclear Information System (INIS)

    The American Petroleum Institute (API) is a trade association for the domestic petroleum industry in the USA, with over 2000 corporate and 5000 individual members. Subsurface research activities are managed by the API soil/groundwater technical task force, a committee made up of over 25 member company engineers, hydrologists, soil scientists, and chemists representing both the research and operations sectors of the petroleum industry. The research areas of the group have been divided into five principle areas: biodegradation processes, fate and transport, remediation, decision making tools for remediation, and detection/analytical methods. A summary of each of the current projects in these subject areas is presented

  2. A geographical information system using the Google Map API for guidance to referral hospitals.

    Science.gov (United States)

    Kobayashi, Shinji; Fujioka, Tetsushi; Tanaka, Yuji; Inoue, Michiyoshi; Niho, Yoshiyuki; Miyoshi, Akira

    2010-12-01

    Our hospital acts as a regional core hospital through inter-hospital collaboration. Geographical information is necessary to guide patients to the other hospitals. Although paper maps, which contain directions, nearest public transportation, etc., are usually provided to guide patients to the hospitals, the geographical information tends to change daily. However, updating the geographical information on the maps is costly. We constructed an electronic geographical information system using the Google Map API ( http://code.google.com/apis/maps/ ) with open source software to improve our ability to collaborate with other clinics.

  3. Lowering the learning curve for declarative programming: a Python API for the IDP system

    OpenAIRE

    Vennekens, Joost

    2015-01-01

    Programmers may be hesitant to use declarative systems, because of the associated learning curve. In this paper, we present an API that integrates the IDP Knowledge Base system into the Python programming language. IDP is a state-of-the-art logical system, which uses SAT, SMT, Logic Programming and Answer Set Programming tech- nology. Python is currently one of the most widely used (teaching) lan- guages for programming. The first goal of our API is to allow a Python programmer to use the dec...

  4. Perfil dos pacientes na Lista Única de Espera para transplante cardíaco no estado do Ceará Perfil de los pacientes en la lista única de espera para transplante cardíaco en el estado de Ceará Profile of patients in the Unified Waiting List for heart transplantation in state of Ceará

    Directory of Open Access Journals (Sweden)

    Francisca Elisângela Teixeira Lima

    2010-07-01

    Full Text Available FUNDAMENTO: Os transplantes de órgãos têm aumentado consideravelmente nos últimos anos em razão da evolução tecnológica e da sensibilização da sociedade para doação de órgãos. OBJETIVO: Descrever as características dos pacientes da Lista Única de Espera para transplante cardíaco; identificar as principais cardiopatias; e verificar o tempo médio de permanência do paciente na Lista até a realização da cirurgia. MÉTODOS: Trata-se de um estudo descritivo, documental e retrospectivo, com abordagem quantitativa, desenvolvido na Central de Transplante do Estado do Ceará, com 156 pacientes incluídos na Lista Única de Espera do ano de 1999 a 2006. Os dados foram organizados em figuras. RESULTADOS: Foram encontrados: 81% do sexo masculino; 22,4% adultos jovens (20 a 40 anos e 56,4% adultos de meia-idade (40 a 64 anos, com uma média de 36 anos; 79% procedentes de Fortaleza-CE; 91% tinham miocardiopatia como causa do transplante cardíaco. Dentre esses pacientes 102 (69% foram transplantados; 37 (25% evoluíram para óbito antes do transplante e 8 (6% foram excluídos por melhora ou piora do quadro clínico. CONCLUSÃO: Os pacientes da Lista Única de Espera para transplante cardíaco no Estado do Ceará, no período de 1999 a 2006, eram do sexo masculino (80%, com faixa etária variando de 1 a 71 anos, com predomínio da miocardiopatia dilatada (53,4%, e o tempo médio de espera foi de 136 dias até o dia do transplante cardíaco.FUNDAMENTO: Los transplantes de órganos han aumentado considerablemente en los últimos años, en razón de la evolución tecnológica y de la sensibilización de la sociedad para la donación de órganos. OBJETIVO: Describir las características de los pacientes de la Lista Única de Espera para transplante cardíaco; identificar las principales cardiopatías; y verificar el tiempo medio de permanencia del paciente en la Lista hasta la realización de la cirugía. MÉTODOS: Se trata de un estudio

  5. Prevalence of nursing diagnosis of decreased cardiac output and the predictive value of defining characteristics in patients under evaluation for heart transplant Prevalencia del diagnóstico de enfermería de disminución del gasto cardíaco y valor predictivo de las características definidoras en pacientes en fase de evaluación para trasplante cardíaco Prevalência do diagnóstico de enfermagem de débito cardíaco diminuído e valor preditivo das características definidoras em pacientes em avaliação para transplante cardíaco

    Directory of Open Access Journals (Sweden)

    Lígia Neres Matos

    2012-04-01

    Full Text Available The purposes of the study were to identify the prevalence of defining characteristics (DC of decreased cardiac output (DCO in patients with cardiac insufficiency under evaluation for heart transplantation, and to ascertain the likelihood of defining characteristics being predictive factors for the existence of reduction in cardiac output. Data was obtained by retrospective documental analysis of the clinical records of right-sided heart catheterizations in 38 patients between 2004 and 2009. The results showed that 71.1% of the patients had decreased cardiac output (measured by cardiac index. The majority of the NANDA-International defining characteristics for DCO were more frequent in individuals with reduced cardiac index levels. The study emphasizes the odds ratio (OR for increased Systemic Vascular Resistance of OR=4.533, of the third heart sound with OR=3.429 and the reduced ejection fraction with OR=2.850. By obtaining the predictive values for the defining characteristics the study identifies them as diagnostic indicators of decreased cardiac output.El estudio tiene como objetivos identificar la prevalencia de las características definitorias de la disminución del gasto cardíaco (DGC en pacientes con insuficiencia cardíaca (IC en evaluación para el trasplante de corazón y ver la probabilidad de las características definitorias sean factores predictivos de la existencia de una disminución del gasto cardíaco. Los datos se obtuvieron mediante el análisis documental retrospectivo de historias clínicas de cateterismo cordiaco derecho en 38 pacientes con insuficiencia cardíaca en la evaluación para el trasplante de corazón entre 2004 y 2009. Los resultados mostraron que el 71% de los pacientes habían reducido el gasto cardíaco (medido por el índice cardíaco. La mayoría de las características definitorias de la NANDA-International para el DGC fueron más frecuentes en individuos con índice cardíaco reducido. Los aspectos m

  6. An example of how to handle amorphous fractions in API during early pharmaceutical development: SAR114137--a successful approach.

    Science.gov (United States)

    Petzoldt, Christine; Bley, Oliver; Byard, Stephen J; Andert, Doris; Baumgartner, Bruno; Nagel, Norbert; Tappertzhofen, Christoph; Feth, Martin Philipp

    2014-04-01

    The so-called pharmaceutical solid chain, which encompasses drug substance micronisation to the final tablet production, at pilot plant scale is presented as a case study for a novel, highly potent, pharmaceutical compound: SAR114137. Various solid-state analytical methods, such as solid-state Nuclear Magnetic Resonance (ssNMR), Differential Scanning Calorimetry (DSC), Dynamic Water Vapour Sorption Gravimetry (DWVSG), hot-stage Raman spectroscopy and X-ray Powder Diffraction (XRPD) were applied and evaluated to characterise and quantify amorphous content during the course of the physical treatment of crystalline active pharmaceutical ingredient (API). DSC was successfully used to monitor the changes in amorphous content during micronisation of the API, as well as during stability studies. (19)F solid-state NMR was found to be the method of choice for the detection and quantification of low levels of amorphous API, even in the final drug product (DP), since compaction during tablet manufacture was identified as a further source for the formation of amorphous API. The application of different jet milling techniques was a critical factor with respect to amorphous content formation. In the present case, the change from spiral jet milling to loop jet milling led to a decrease in amorphous API content from 20-30 w/w% to nearly 0 w/w% respectively. The use of loop jet milling also improved the processability of the API. Stability investigations on both the milled API and the DP showed a marked tendency for recrystallisation of the amorphous API content on exposure to elevated levels of relative humidity. No significant impact of amorphous API on either the chemical stability or the dissolution rate of the API in drug formulation was observed. Therefore, the presence of amorphous content in the oral formulation was of no consequence for the clinical trial phases I and II. PMID:24075979

  7. Testing of the structure of macromolecular polymer films containing solid active pharmaceutical ingredient (API) particles

    Energy Technology Data Exchange (ETDEWEB)

    Boelcskei, E. [Department of Pharmaceutical Technology, University of Szeged, H-6720 Szeged, Eoetvoes u. 6 (Hungary); Suevegh, K. [Laboratory of Nuclear Chemistry, Eoetvoes Lorand University, H-1518 Budapest 112, P.O. Box 32 (Hungary); Marek, T. [Hungarian Academy of Sciences, Research Group for Nuclear Techniques in Structural Chemistry, Eoetvoes Lorand University, H-1518 Budapest 112, P.O. Box 32 (Hungary); Regdon, G. [Department of Pharmaceutical Technology, University of Szeged, H-6720 Szeged, Eoetvoes u. 6 (Hungary); Pintye-Hodi, K., E-mail: klara.hodi@pharm.u-szeged.h [Department of Pharmaceutical Technology, University of Szeged, H-6720 Szeged, Eoetvoes u. 6 (Hungary)

    2011-07-15

    The aim of the present study was to investigate the structure of free films of Eudragit{sup L} 30D-55 containing different concentrations (0%, 1% or 5%) of diclofenac sodium by positron annihilation spectroscopy. The data revealed that the size of the free-volume holes and the lifetimes of ortho-positronium atoms decreased with increase of the API concentration. Films containing 5% of the API exhibited a different behavior during storage (17 {sup o}C, 65% relative humidity (RH)) in consequence of the uptake of water from the air. -- Highlights: {yields} The aim of the present study was to investigate the structure of free films of Eudragit{sup L} 30D-55 containing different concentrations (0%, 1% or 5%) of diclofenac sodium by positron annihilation spectroscopy. {yields} The data revealed that the size of the free-volume holes and the lifetimes of ortho-positronium atoms decreased with increase of the API concentration (). {yields} The API distorts the original polymer structure, but as time goes by, the metastable structure relaxes and it is almost totally restored after 3 weeks of storage (17 {sup o}C, 65% RH).

  8. Does Year Round Schooling Affect the Outcome and Growth of California's API Scores?

    Science.gov (United States)

    Wu, Amery D.; Stone, Jake E.

    2010-01-01

    This paper examined whether year round schooling (YRS) in California had an effect upon the outcome and growth of schools' Academic Performance Index (API) scores. While many previous studies had examined the connection between YRS and academic achievement, most had lacked the statistical rigour required to provide reliable interpretations. As a…

  9. An Auto-Configuration System for the GMSEC Architecture and API

    Science.gov (United States)

    Moholt, Joseph; Mayorga, Arturo

    2007-01-01

    A viewgraph presentation on an automated configuration concept for The Goddard Mission Services Evolution Center (GMSEC) architecture and Application Program Interface (API) is shown. The topics include: 1) The Goddard Mission Services Evolution Center (GMSEC); 2) Automated Configuration Concept; 3) Implementation Approach; and 4) Key Components and Benefits.

  10. Involvement of Phosphorylated "Apis Mellifera" CREB in Gating a Honeybee's Behavioral Response to an External Stimulus

    Science.gov (United States)

    Gehring, Katrin B.; Heufelder, Karin; Feige, Janina; Bauer, Paul; Dyck, Yan; Ehrhardt, Lea; Kühnemund, Johannes; Bergmann, Anja; Göbel, Josefine; Isecke, Marlene; Eisenhardt, Dorothea

    2016-01-01

    The transcription factor cAMP-response element-binding protein (CREB) is involved in neuronal plasticity. Phosphorylation activates CREB and an increased level of phosphorylated CREB is regarded as an indicator of CREB-dependent transcriptional activation. In honeybees ("Apis mellifera") we recently demonstrated a particular high…

  11. Reliability of the Advanced Psychodiagnostic Interpretation (API) Scoring System for the Bender Gestalt.

    Science.gov (United States)

    Aucone, Ernest J.; Raphael, Alan J.; Golden, Charles J.; Espe-Pfeifer, Patricia; Seldon, Jen; Pospisil, Tanya; Dornheim, Liane; Proctor-Weber, Zoe; Calabria, Michael

    1999-01-01

    Assessed the interrater reliability of the revised Advanced Psychodiagnostic Interpretation (API) (A. Raphael and C. Golden, 1998) scoring system for the Bender Gestalt Test (L. Bender, 1938). Agreement across nine raters exceeded 90% for each of three clinical protocols, and kappa statistics indicated good interrater reliability. (SLD)

  12. Asymmetrical Coexistence of Nosema ceranae and N. apis in Honey Bees

    Science.gov (United States)

    Globalization has provided opportunities for parasites/pathogens to cross geographic boundaries and expand to new hosts. Recent studies showed that Nosema ceranae, originally considered as a microsporidian parasite of Eastern honey bees, Apis ceranae, was the disease agent of Nosemosis in European ...

  13. ACME algorithms for contact in a multiphysics environment API version 2.2.

    Energy Technology Data Exchange (ETDEWEB)

    Heinstein, Martin Wilhelm; Glass, Micheal W.; Gullerud, Arne S.; Brown, Kevin H.; Voth, Thomas Eugene; Jones, Reese E.

    2004-07-01

    An effort is underway at Sandia National Laboratories to develop a library of algorithms to search for potential interactions between surfaces represented by analytic and discretized topological entities. This effort is also developing algorithms to determine forces due to these interactions for transient dynamics applications. This document describes the Application Programming Interface (API) for the ACME (Algorithms for Contact in a Multiphysics Environment) library.

  14. Responses of Varroa-resistant honey bees (Apis mellifera L.) to Deformed wing virus

    Science.gov (United States)

    The negative impact of Deformedwing virus (DWV) on European honey bees Apis mellifera is magnified by Varroa destructor parasitism. This study compared the responses of two Varroa-resistant honey bee stocks, pure Russian honey bees (RHB) and out-crossed Varroa Sensitive Hygienic bees, Pol-line (POL)...

  15. Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): review.

    Science.gov (United States)

    Li, Du-Xin; Gan, Lin; Bronja, Amela; Schmitz, Oliver J

    2015-09-01

    Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a "soft" ion source for preserving highly diagnostic molecular ion is desirable, as compared to the "hard" ionization technique such as electron ionization (EI) in traditional GC/MS, which fragments the molecule in an extensive way. These API sources include atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), atmospheric pressure laser ionization (APLI), electrospray ionization (ESI) and low temperature plasma (LTP). This review discusses the advantages and drawbacks of this analytical platform. After an introduction in atmospheric pressure ionization the review gives an overview about the history and explains the mechanisms of various atmospheric pressure ionization techniques used in combination with GC such as APCI, APPI, APLI, ESI and LTP. Also new developments made in ion source geometry, ion source miniaturization and multipurpose ion source constructions are discussed and a comparison between GC-FID, GC-EI-MS and GC-API-MS shows the advantages and drawbacks of these techniques. The review ends with an overview of applications realized with GC-API-MS.

  16. The Earth Observatory Natural Event Tracker (EONET): An API for Matching Natural Events to GIBS Imagery

    Science.gov (United States)

    Ward, K.

    2015-12-01

    Hidden within the terabytes of imagery in NASA's Global Imagery Browse Services (GIBS) collection are hundreds of daily natural events. Some events are newsworthy, devastating, and visibly obvious at a global scale, others are merely regional curiosities. Regardless of the scope and significance of any one event, it is likely that multiple GIBS layers can be viewed to provide a multispectral, dataset-based view of the event. To facilitate linking between the discrete event and the representative dataset imagery, NASA's Earth Observatory Group has developed a prototype application programming interface (API): the Earth Observatory Natural Event Tracker (EONET). EONET supports an API model that allows users to retrieve event-specific metadata--date/time, location, and type (wildfire, storm, etc.)--and web service layer-specific metadata which can be used to link to event-relevant dataset imagery in GIBS. GIBS' ability to ingest many near real time datasets, combined with its growing archive of past imagery, means that API users will be able to develop client applications that not only show ongoing events but can also look at imagery from before and after. In our poster, we will present the API and show examples of its use.

  17. Biotyping of Haemophilus using API 10S—an epidemiological tool?

    OpenAIRE

    Mehtar, S.; Afshar, S Amini

    1983-01-01

    One hundred and ninety-nine strains of Haemophilus isolates were biotyped by Kilian's method1 and a modified API 10S strip and the results compared. One hundred percent correlation was found between the two systems. The ONPG test proved of value in differentiating between Haemophilus influenzae and Haemophilus parainfluenzae when there was growth factor disc failure.

  18. Synergistic effects of non-Apis bees and honey bees for pollination services.

    Science.gov (United States)

    Brittain, Claire; Williams, Neal; Kremen, Claire; Klein, Alexandra-Maria

    2013-03-01

    In diverse pollinator communities, interspecific interactions may modify the behaviour and increase the pollination effectiveness of individual species. Because agricultural production reliant on pollination is growing, improving pollination effectiveness could increase crop yield without any increase in agricultural intensity or area. In California almond, a crop highly dependent on honey bee pollination, we explored the foraging behaviour and pollination effectiveness of honey bees in orchards with simple (honey bee only) and diverse (non-Apis bees present) bee communities. In orchards with non-Apis bees, the foraging behaviour of honey bees changed and the pollination effectiveness of a single honey bee visit was greater than in orchards where non-Apis bees were absent. This change translated to a greater proportion of fruit set in these orchards. Our field experiments show that increased pollinator diversity can synergistically increase pollination service, through species interactions that alter the behaviour and resulting functional quality of a dominant pollinator species. These results of functional synergy between species were supported by an additional controlled cage experiment with Osmia lignaria and Apis mellifera. Our findings highlight a largely unexplored facilitative component of the benefit of biodiversity to ecosystem services, and represent a way to improve pollinator-dependent crop yields in a sustainable manner. PMID:23303545

  19. Polymorphic DNA sequences of the fungal honey bee pathogen Ascosphaera apis

    DEFF Research Database (Denmark)

    Jensen, Annette B; Welker, Dennis L; Kryger, Per;

    2012-01-01

    The pathogenic fungus Ascosphaera apis is ubiquitous in honey bee populations. We used the draft genome assembly of this pathogen to search for polymorphic intergenic loci that could be used to differentiate haplotypes. Primers were developed for five such loci, and the species specificities were...... for the world's most important pollinator: the honey bee and one of its most common pathogens....

  20. Insights into social insects from the genome of the honeybee Apis mellifera

    DEFF Research Database (Denmark)

    Hauser, Frank; Cazzamali, Giuseppe; Williamson, Michael;

    2006-01-01

    Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more...

  1. The API methodology for risk-based inspection (RBI) analysis for the petroleum and petrochemical industry

    International Nuclear Information System (INIS)

    Twenty-one petroleum and petrochemical companies are currently sponsoring a project within the American Petroleum Institute (API) to develop risk-based inspection (RBI) methodology for application in the refining and petrochemical industry. This paper describes that particular RBI methodology and provides a summary of the three levels of RBI analysis developed by the project. Also included is a review of the first pilot project to validate the methodology by applying RBI to several existing refining units. The failure for pressure equipment in a process unit can have several undesirable effects. For the purpose of RBI analysis, the API RBI program categorizes these effects into four basic risk outcomes: flammable events, toxic releases, major environmental damage, and business interruption losses. API RBI is a strategic process, both qualitative and quantitative, for understanding and reducing these risks associated with operating pressure equipment. This paper will show how API RBI assesses the potential consequences of a failure of the pressure boundary, as well as assessing the likelihood (probability) of failure. Risk-based inspection also prioritizes risk levels in a systematic manner so that the owner-user can then plan an inspection program that focuses more resources on the higher risk equipment; while possibly saving inspection resources that are not doing an effective job of reducing risk. At the same time, if consequence of failure is a significant driving force for high risk equipment items, plant management also has the option of applying consequence mitigation steps to minimize the impact of a hazardous release, should one occur. The target audience for this paper is engineers, inspectors, and managers who want to understand what API Risk-Based Inspection is all about, what are the benefits and limitations of RBI, and how inspection practices can be changed to reduce risks and/or save costs without impacting safety risk. (Author)

  2. Alteration Summary of the 8th Edition API SPEC Q1 as Opposed to the 7th Edition%API SPEC Q1第8版相对第7版变更摘要

    Institute of Scientific and Technical Information of China (English)

    方晓东

    2009-01-01

    @@ API SPEC Q1是API标准中一项重要的技术政策性标准,通用于API的所有产品规范.API Q1第8版于2007年12月发布, 2008年6月15日生效.2008年6月15日以后对申请会标公司质量管理体系的审核,将按API Q1第8版的要求进行.

  3. Expression of ACO1, ERS1 and ERF1 genes in harvested bananas in relation to heat-induced defense against Colletotrichum musae.

    Science.gov (United States)

    Zhu, Xiangfei; Wang, Aiping; Zhu, Shijiang; Zhang, Lubin

    2011-09-15

    The aim of this study was to investigate the connection between heat-induced ethylene signal changes and enhanced disease resistance. Heat enhanced ripening and elevated MaACO1 expression in naturally ripened bananas (NRB), while it delayed ripening and reduced MaACO1expression in the ethephon-treated bananas (ETB). However, in both cases, heat reduced lesion sizes infected by Colletotrichum musae. This indicates that heat-induced disease resistance in bananas was independent of ripening rate. The expression of MaERS1 gene was inhibited by heat treatment in both NRB and ETB, implying that heat as a physical signal could be sensed by banana fruits through the inhibition of ethylene receptor gene expression. The intensity of MaERF1 transcript signals was elevated in heated bananas, suggesting that the enhanced accumulation of MaERF1 transcript following heat treatment could play an important role in activation of the defense system. In ETB, inhibition of JA biosynthesis by application of IBU down-regulated the expression of MaERF and significantly weakened disease resistance, suggesting involvement of endogenous JA in induction of the gene expression, which was reconfirmed by the fact that exposure to exogenous MeJA following the combination of heat plus IBU treatment restored part of the gene expression. On the other hand, in NRB, application of IBU elevated level of MaERF1 expression at 24h and enhanced disease resistance, suggesting that, when banana was not exposed to ethephon, the expression of MaERF1 gene was not JA dependent, which was verified by the fact that MeJA application did not enhance MaERF1 gene expression. In conclusion, heat-induced disease resistance in harvested bananas could involve down-regulation of MaERS1 expression and up-regulation of MaERF1 expression and JA pathway could be involved in heat activation of the defense system in bananas exposed to ethephon.

  4. Energy-Balance Adaptive Routing Algorithm Based on ACO%基于蚁群优化的能量均衡自适应路由算法

    Institute of Scientific and Technical Information of China (English)

    杨大鹏

    2013-01-01

    The routing algorithm based ACO (Ant Colony Optimization) has good performance in WSNs (Wire⁃less Sensor Networks),for its several advantages,such as positive feedback,distributed computing,robustness and parallelism. But the algorithm also costs a lot in exploring optimization. Based on ACO’s characteristics and lim⁃itation of energy in WSNs, an ACO based energy-balance adaptive routing algorithm was proposed. A new phero⁃mone update operator was designed to integrate energy consumption and hops into routing choice. Energy level⁃ing elements of network was introduced in the operator. During routing maintenance, the new algorithm took adaptive routing maintenance mechanism based on sense ants. Simulation results showed that the proposed algo⁃rithm obviously reduced the energy consumption and prolonged the lifetime of WSNs.%  基于蚁群优化的WSNs路由算法具有蚁群优化自组织性、正反馈性和并行性的特点,在构造无线传感器网络中的最优路由时有很好的性能。但是蚁群优化构造最优解时带来的网络开销十分可观,不适合在路由维护阶段反复使用蚁群优化重构路由。考虑到蚁群优化的上述特点,同时针对无线传感器网络能量受限的特点,提出了一种基于蚁群优化的能量均衡自适应路由算法。该算法使用了新的信息素更新算子,算子中包含了网络能量水平因子,能够均衡网络能量消耗。在路由维护阶段,该算法使用了新的基于侦测蚂蚁的自适应路由维护机制,很好地降低了网络开销。

  5. Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report Hemorragia em metástase cerebral de angiossarcoma cardíaco: relato de caso

    Directory of Open Access Journals (Sweden)

    Pasquale Gallo

    2001-09-01

    Full Text Available The purpose of this article is to describe the clinical and pathological features of metastatic angiosarcoma in the central nervous system. Only a few cases of cerebral metastasis from angiosarcoma of the heart have been recorded in the literature; particulary related to intracerebral hemorrhage. A case of secondary cerebral angiosarcoma of the heart in a 33 years old man is presented. The initial symptoms were headache, vomiting, lethargy and aphasia. There was a mass in the left temporal lobe with hemorrhage and edema on the computerized tomography (CT. After 24 hours the neurological status worsened and another CT scan showed rebleeding on the tumor area. He underwent an emergency craniotomy but died two days after. Considering the longer survival of sarcoma patients with new modalities of treatment, the incidence of brain metastasis may increase, demanding a bether preventive and more aggressive approach. Besides, due to the hemorrhagic nature of such lesions, we suggest the imediate surgery to prevent a fast and lethal evolution because rebleeding.O propósito deste artigo é descrever os achados clínicos e patológicos das metástases de angiossarcoma no sistema nervoso central. Apenas poucos casos de metástases cerebrais de angiossarcoma cardíaco foram relatados na literatura, menos ainda relacionados a hemorragia intracerebral. Relatamos o caso de um tumor cerebral secundário a angiossarcoma cardíaco em um paciente masculino de 33 anos. Os sintomas iniciais foram: cefaléia, vômitos, letargia e afasia. A tomografia computadorizada mostrou massa no lobo temporal esquerdo associada a hemorragia e edema. Após 24 horas houve piora do estado neurológico e nova tomografia demonstrou ressangramento no leito tumoral. Foi submetido a uma craniotomia de urgência mas faleceu dois dias após. Considerando a longa sobrevida dos pacientes com sarcoma devido às novas modalidades terapêuticas, poderá aumentar a incidência de met

  6. Variation morphogeometrics of Africanized honey bees (Apis mellifera in Brazil Variação morfogeométrica das abelhas africanizadas (Apis mellifera no Brasil

    Directory of Open Access Journals (Sweden)

    Lorena A. Nunes

    2012-09-01

    Full Text Available The morphometrics of the honey bee Apis mellifera L., 1758 has been widely studied mainly because this species has great ecological importance, high adaptation capacity, wide distribution and capacity to effectively adapt to different regions. The current study aimed to investigate the morphometric variations of wings and pollen baskets of honey bees Apis mellifera scutellata Lepeletier, 1836 from the five regions in Brazil. We used geometric morphometrics to identify the existence of patterns of variations of shape and size in Africanized honey bees in Brazil 16 years after the classic study with this species, allowing a temporal and spatial comparative analysis using new technological resources to assess morphometrical data. Samples were collected in 14 locations in Brazil, covering the five geographical regions of the country. The shape analysis and multivariate analyses of the wing allowed to observe that there is a geographical pattern among the population of Apis mellifera in Brazil. The geographical variations may be attributed to the large territorial extension of the country in addition to the differences between the bioregions.Apis mellifera L., 1758 têm sido alvo de muitos estudos morfométricos principalmente pela sua importância ecológica, pela sua grande capacidade de adaptação, sua ampla distribuição e por serem capazes de se estabelecer eficientemente em diversas regiões. O presente trabalho teve como objetivo estudar as variações da forma em asas e corbículas de operárias de Apis mellifera scutellata Lepeletier, 1836 provenientes das cinco regiões biogeográficas do Brasil utilizando análises morfogeométricas, a fim de verificar a existência de padrões de variação de forma e tamanho das abelhas africanizadas no Brasil após 16 anos do estudo clássico realizado com esta espécie, possibilitando uma análise espaço-temporal comparativa utilizando recursos tecnológicos atuais para a avaliação de dados morfom

  7. Desarrollo de una escala de auto-reporte para medición de síntomas maníacos

    Directory of Open Access Journals (Sweden)

    Karol Barrios

    2013-09-01

    Full Text Available Resumen Antecedentes. No existen instrumentos de auto-reporte en español para medir síntomas de trastorno bipolar. La perspectiva del paciente puede dar información complementaria de utilidad para el diagnóstico y manejo de la enfermedad. Objetivo. Desarrollar una escala de auto-reporte para medir síntomas maníacos, a partir de la escala EMUN. Materiales y métodos. Los ítems de la escala EMUN se transformaron a un lenguaje en primera persona por parte de dos psiquiatras. Esta versión preliminar en primera persona fue analizada en un estudio piloto y ajustada de acuerdo con los resultados de la evaluación. Se realizó un segundo estudio piloto con 20 pacientes con enfermedad bipolar, aplicando la versión ajustada. Resultados. Se generó una escala con 26 ítems que incorporan síntomas del episodio mixto. La escala mide tres dimensiones de importancia clínica en salud mental: frecuencia, intensidad y grado de desadaptación producido por los síntomas. Conclusión. El instrumento desarrollado puede ser de utilidad en áreas de investigación y en escenarios clínicos para intervenciones psicoeducativas y seguimiento del paciente.

  8. The Norma cluster (ACO3627) -- III. The Distance and Peculiar Velocity via the Near-Infrared Ks-band Fundamental Plane

    CERN Document Server

    Mutabazi, T; Woudt, P A; Lucey, J R; Jarrett, T H; Bilicki, M; Schroder, A C; Moore, S A W

    2014-01-01

    While Norma (ACO3627) is the richest cluster in the Great Attractor (GA) region, its role in the local dynamics is poorly understood. The Norma cluster has a mean redshift (z_CMB) of 0.0165 and has been proposed as the "core" of the GA. We have used the Ks-band Fundamental Plane (FP) to measure Norma cluster's distance with respect to the Coma cluster. We report FP photometry parameters (effective radii and surface brightnesses), derived from ESO NTT SOFI images, and velocity dispersions, from AAT 2dF spectroscopy, for 31 early-type galaxies in the cluster. For the Coma cluster we use 2MASS images and SDSS velocity dispersion measurements for 121 early-type galaxies to generate the calibrating FP dataset. For the combined Norma-Coma sample we measure FP coefficients of a=1.465+/-0.059 and b=0.326+/-0.020. We find an rms scatter, in log(sigma) of 0.08 dex which corresponds to a distance uncertainty of 28% per galaxy. The zero point offset between Norma's and Coma's FPs is 0.154+\\-0.014 dex. Assuming that the C...

  9. A Transition from Localized to Strongly Correlated Electron Behavior and Mixed Valence Driven by Physical or Chemical Pressure in ACo2As2 (A = Eu and Ca)

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Xiaoyan; Fabbris, Gilberto; Haskel, Daniel; Yaroslavtsev, Alexander A.; Cao, H.; Thompson, Corey M.; Kovnir, Kirill; Menushenkov, Alexey P.; Chernikov, Roman V.; Garlea, V. Ovidiu; Shatruk, Michael

    2016-03-02

    We demonstrate that the action of physical pressure, chemical compression, or aliovalent substitution in ACo(2)As(2) (A = Eu and Ca) has a general consequence of causing these antiferromagnetic materials to become ferromagnets. In all cases, the mixed valence triggered at the electropositive A site results in the increase of the Co 3d density of states at the Fermi level. Remarkably, the dramatic alteration of magnetic behavior results from the very minor (<0.15 eleetron) change in the population of the 3d orbitals. The mixed valence state of En observed in the high-pressure (HP) form of EuCo2As2 exhibits a remarkable stability, achieving the average oxidation state of +2.25 at 12.6 GPa. In the case of CaCo2As2, substituting even 10% of Eu or La into the Ca site causes ferromagnetic ordering of Co moments. Similar to HP-EuCo2As2, the itinerant 3d ferromagnetism emerges from electronic doping into the Co layer because of chemical compression of Eu sites in Ca0.9Eu0.1Co1.91As2 or direct electron doping in Ca0.85La0.15Co1.89As2. The results reported herein demonstrate the general possibility of amplifying minor localized electronic effects to achieve major changes in material's properties via involvement of strongly correlated electrons.

  10. Electrospun poly(bisphenol A-co-4-nitrophthalic anhydride-co-1,3-phenylenediamine fibers: Preparation and potential for use in filtration applications

    Directory of Open Access Journals (Sweden)

    Patcharaporn Thitiwongsawet

    2011-06-01

    Full Text Available Poly(bisphenol A-co-4-nitrophthalic anhydride-co-1,3-phenylenediamine (PEI fibers were successfully prepared byelectrospinning from PEI solutions in dichloromethane (DCM, 1,2-dichloroethane (DCE, N-methylpyrrolidone (NMP andcertain mixtures between NMP and N,N-dimethylformamide (DMF. Electrospinnability of PEI solutions in NMP was greaterthan that in DCM and DCE. The addition of DMF with NMP for the preparation of PEI solutions helped improve electrospinnabilityof the PEI solutions. The effect of solution concentration on morphological appearance and/or size of the obtainedproducts was investigated. At low concentrations of the PEI solutions, discrete beads and/or beaded fibers was formed.Smooth fibers were obtained at the highest concentration investigated, i.e., 20% (w/v. The size of the obtained fibers wasfound to be an increasing function with the solution concentration or, to be exact, the solution viscosity. The water fluxesthrough the electrospun fiber mats prepared from 20% (w/v PEI solutions in 75/25 and 50/50 NMP/DMF mixtures wereinvestigated in comparison with the films prepared by phase immersion-precipitation technique. The fiber mats exhibitedmuch greater fluxes of water than the films, which implied their potential for uses as filtration membranes.

  11. Experiência com transplante cardíaco heterotópico em pacientes com resistência pulmonar elevada: seguimento tardio Experiencia con trasplante cardíaco heterotópico en pacientes con resistencia pulmonar elevada: seguimiento tardío Experience with heterotopic heart transplantation in patients with elevated pulmonary vascular resistance: late follow-up

    Directory of Open Access Journals (Sweden)

    Jose Henrique Andrade Vila

    2010-02-01

    Full Text Available FUNDAMENTO: Nos últimos anos o numero de artigos sobre transplante cardíaco heterotópico tem sido escasso na literatura, inclusive internacional, e em particular do seguimento de longo prazo destes pacientes, o que levou ao presente relato. OBJETIVO: Relatar a experiência clínica inicial e evolução tardia de quatro pacientes submetidos a transplante cardíaco heterotópico, sua indicação e principais complicações. MÉTODOS: As cirurgias ocorreram entre 1992 e 2001, sendo que a indicação de transplante heterotópico, em todas, foi pela RVP, variável de 4,8UW a 6.5UW, com gradiente transpulmonar acima de 15mmHg. No 3º paciente, foi realizada uma anastomose direta entre as artérias pulmonares sem emprego de tubo protético e, no coração nativo, foi realizada uma valvoplastia mitral e aneurismectomia de ventrículo esquerdo (VE. O esquema imunossupressor imediato foi duplo com ciclosporina e azatioprina nos três primeiros pacientes e ciclosporina e micofenolato mofetil no 4º paciente. RESULTADOS: Um óbito imediato por falência do enxerto, um óbito após dois anos e meio por endocardite em trombo intraventricular no coração nativo, e um terceiro óbito seis anos após o transplante, por complicações pós-operatórias de cirurgia na valva aórtica do coração nativo. O remanescente, 15 anos após o transplante, encontra-se bem, em classe funcional II (NYHA, seis anos após a oclusão cirúrgica da valva aórtica do coração nativo. CONCLUSÃO: O transplante cardíaco heterotópico é um procedimento com resultado inferior ao transplante cardíaco ortotópico, por apresentarem maior RVP. Os trombos intraventriculares no coração nativo, que exigem anticoagulação prolongada, bem como as complicações de válvula aórtica, também no coração nativo, podem exigir tratamento cirúrgico. Entretanto, em um paciente, a sobrevida de 15 anos mostrou a eficácia de longo prazo desse tipo de alternativa, para pacientes

  12. Vitellogenins are new high molecular weight components and allergens (Api m 12 and Ves v 6 of Apis mellifera and Vespula vulgaris venom.

    Directory of Open Access Journals (Sweden)

    Simon Blank

    Full Text Available BACKGROUND/OBJECTIVES: Anaphylaxis due to hymenoptera stings is one of the most severe clinical outcomes of IgE-mediated hypersensitivity reactions. Although allergic reactions to hymenoptera stings are often considered as a general model for the underlying principles of allergic disease, venom immunotherapy is still hampered by severe systemic side effects and incomplete protection. The identification and detailed characterization of all allergens of hymenoptera venoms might result in an improvement in this field and promote the detailed understanding of the allergological mechanism. Our aim was the identification and detailed immunochemical and allergological characterization of the low abundant IgE-reactive 200 kDa proteins of Apis mellifera and Vespula vulgaris venom. METHODS/PRINCIPAL FINDINGS: Tandem mass spectrometry-based sequencing of a 200 kDa venom protein yielded peptides that could be assigned to honeybee vitellogenin. The coding regions of the honeybee protein as well as of the homologue from yellow jacket venom were cloned from venom gland cDNA. The newly identified 200 kDa proteins share a sequence identity on protein level of 40% and belong to the family of vitellogenins, present in all oviparous animals, and are the first vitellogenins identified as components of venom. Both vitellogenins could be recombinantly produced as soluble proteins in insect cells and assessed for their specific IgE reactivity. The particular vitellogenins were recognized by approximately 40% of sera of venom-allergic patients even in the absence of cross-reactive carbohydrate determinants. CONCLUSION: With the vitellogenins of Apis mellifera and Vespula vulgaris venom a new homologous pair of venom allergens was identified and becomes available for future applications. Due to their allergenic properties the honeybee and the yellow jacket venom vitellogenin were designated as allergens Api m 12 and Ves v 6, respectively.

  13. An Update to the EARTHTIME Argon Intercalibration Pipette System (APIS): Smoking from the Same Pipe

    Science.gov (United States)

    Turrin, B. D.; Swisher, C. C., III; Hemming, S. R.; Renne, P. R.; Deino, A. L.; Hodges, K. V.; Van Soest, M. C.; Heizler, M. T.

    2015-12-01

    Background: An initial 40Ar/39Ar inter-calibration experiment, using two of the most commonly used 40Ar/39Ar mineral standards, Fish Canyon (FC, ~28.2 Ma) and Alder Creek (AC, ~1.2 Ma) sanidines, revealed significant inter-laboratory inconsistencies. The reported ages for the AC sanidines range from 1.173 to 1.200 Ma (FC 28.02) (±~2%), ~4 times greater than the reported precisions. These experiments have motivated the 40Ar/39Ar community to reevaluate procedures and subsequent informal lab intercalibrations experiments are in better agreement, but discrepancies remain that need to be addressed. Experiment: In an effort to isolate the causes of these inconsistencies, an Argon Intercalibration Pipette System (APIS) was designed and constructed. The APIS system consists of three gas canisters; one containing atmospheric Ar and the other two canisters contain 40Ar/39Ar ratios that represent FC and AC. The volumes of the pipettes, bulbs and manifold are determined to within 0.4% and both systems were initially filled to the same pressure with Ar standard gases. Each canister has 4x10-10 moles of 40Ar, is equipped with a 0.1, 0.2 and 0.4 cc pipettes and can deliver increments from 0.1-0.7 cc. APIS-1 was designated as the traveling unit that is brought to participating labs, APIS-2 is the reserve/master standard. Early Results and Impressions: APIS-1 has been to four labs (Rutgers, LDEO, New Mexico Tech, and BGC) and is heading to ASU. Early APIS experimental data indicate that the inter-laboratory 40Ar/39Ar age results can meet or exceed the EARTHTIME goal of ±1‰ precision. The inter-laboratory comparisons are ongoing, and will include additional laboratories of opportunity. Lastly, the development of additional mineral standards that "fill in" the age gaps between the existing mineral standards would significantly improve attempting to achieve interlaboratory agreement at the ±1‰ level

  14. OpenSearch (ECHO-ESIP) & REST API for Earth Science Data Access

    Science.gov (United States)

    Mitchell, A.; Cechini, M.; Pilone, D.

    2010-12-01

    This presentation will provide a brief technical overview of OpenSearch, the Earth Science Information Partners (ESIP) Federated Search framework, and the REST architecture; discuss NASA’s Earth Observing System (EOS) ClearingHOuse’s (ECHO) implementation lessons learned; and demonstrate the simplified usage of these technologies. SOAP, as a framework for web service communication has numerous advantages for Enterprise applications and Java/C# type programming languages. As a technical solution, SOAP has been a reliable framework on top of which many applications have been successfully developed and deployed. However, as interest grows for quick development cycles and more intriguing “mashups,” the SOAP API loses its appeal. Lightweight and simple are the vogue characteristics that are sought after. Enter the REST API architecture and OpenSearch format. Both of these items provide a new path for application development addressing some of the issues unresolved by SOAP. ECHO has made available all of its discovery, order submission, and data management services through a publicly accessible SOAP API. This interface is utilized by a variety of ECHO client and data partners to provide valuable capabilities to end users. As ECHO interacted with current and potential partners looking to develop Earth Science tools utilizing ECHO, it became apparent that the development overhead required to interact with the SOAP API was a growing barrier to entry. ECHO acknowledged the technical issues that were being uncovered by its partner community and chose to provide two new interfaces for interacting with the ECHO metadata catalog. The first interface is built upon the OpenSearch format and ESIP Federated Search framework. Leveraging these two items, a client (ECHO-ESIP) was developed with a focus on simplified searching and results presentation. The second interface is built upon the Representational State Transfer (REST) architecture. Leveraging the REST architecture, a

  15. Polinização de morangueiro por Apis mellifera em ambiente protegido Strawberry polinization through Apis mellifera in protected environment

    Directory of Open Access Journals (Sweden)

    Eunice Oliveira Calvete

    2010-03-01

    Full Text Available Este trabalho objetivou comparar a produtividade e a qualidade dos frutos comerciáveis no morangueiro, em ambiente protegido, utilizando a espécie de abelha Apis mellifera em relação à ausência de um agente polinizador. Foram instalados dois experimentos, utilizando-se das cultivares Camarosa, Oso Grande, Diamante e Aromas (tratamentos, no período de 05 de maio a 19 de dezembro de 2006. No primeiro experimento, não havia polinizadores (testemunha. O segundo foi polinizado pela espécie de abelha Apis mellifera. Os tratamentos (cultivares foram dispostos, em cada experimento, em um delineamento completamente casualizado, com seis repetições. Foram avaliadas características de rendimento, bem como análise físico-química dos frutos de cada cultivar. Quanto ao rendimento, a maior produção obtida foi com a cultivar Camarosa tanto na ausência quanto na presença de polinizadores (907,46 g. planta-1 e 1.054,93 g. planta-1, respectivamente, ao passo que a cultivar Oso Grande apresentou menor número de frutos deformados.This work objectified to compare the productivity and the quality of the strawberry marketable fruits in protected environment, using the species of bee Apis mellifera in relation of the absence of a polinizator agent. It was installed two experiments using the cultivates Camarosa, Oso Grande, Diamante and Aromas (treatments, in the period of May 5 th until December 19th of 2006. The first experiment did not have polinizatores agents (control. The second was polinizated by the species of bee Apis mellifera. The treatments (cultivars had been arranged, in each experiment in a randomized blocks with 6 repetitions. They were evaluated income characteristics, as well as analysis physicist-chemistry of the fruits of each cultivar. For the income, the biggest production was gotten in cultivar Camarosa, for the first and the second experiment (907,46 g. plant-1 and 1054,93 g. plant-1, respectively, in the way that the cultivate

  16. OWL应用接口的比较分析%Comparative Analysis of APIs for OWL Ontology

    Institute of Scientific and Technical Information of China (English)

    熊振辉; 于娟

    2015-01-01

    The paper comparatively analyzes three types of APIs for OWL, including Jena API、Protégé API and OWL API, from aspects of characteristics, platforms which they base on, languages which they can process and OWL ontology models. It focuses on commonly-used functions of OWL API and obtains related conclusions: (1) Jena API cannot achieve all functions of OWL because it bases on RDF triple;(2) OWL API is specifically designed for OWL and it supports structural specification of OWL2 which is the latest edition of OWL;(3) current APIs for OWL ontology mostly base on Java platform, whereas APIs base on other platforms (e.g. .net plat-form) have not appeared.%比较分析了Jena API、Protégé API、OWL API这三种OWL应用接口(API)的特点、所基于的平台、可处理的语言以及描述OWL本体的模型,重点介绍了OWL API的常用基本功能,得出了相关结论:(1)Jena API基于RDF三元组的特点使其不能实现OWL语言的全部功能;(2)OWL API针对OWL语言设计,且支持最新的OWL2语言的结构规范;(3)目前这些API都是基于Java平台的,对于其它平台(如.net平台),尚未见有成熟的API出现。

  17. Evaluation of different glycoforms of honeybee venom major allergen phospholipase A2 (Api m 1) produced in insect cells

    DEFF Research Database (Denmark)

    Blank, Simon; Seismann, Henning; Plum, Melanie;

    2011-01-01

    Allergic reactions to hymenoptera stings are one of the major reasons for IgE-mediated anaphylaxis. However, proper diagnosis using venom extracts is severely affected by molecular cross-reactivity. In this study recombinant honeybee venom major allergen phospholipase A2 (Api m 1) was produced......-derived recombinant Api m 1 with defined CCD phenotypes might provide further insights into hymenoptera venom IgE reactivities and contribute to an improved diagnosis of hymenoptera venom allergy....

  18. Evaluation of API 20E System and Encise Enterotube for the identification of Enterobacteriaceae of animal origin.

    OpenAIRE

    Devenish, J A; Barnum, D A

    1980-01-01

    The API 20E System and the Encise Enterotube were evaluated for the identification of the Enterobacteriaceae isolated from clinical specimens of animal origin at a veterinary diagnostic laboratory. Compared to conventional tubed media, the API 20E System identified 235 of 240 isolates (97.9%) correctly. The Encise Enterotube correctly identified 229 of the 240 isolates (95.4%). Thus, both these identification systems could be used to replace conventional methods for identifying members of thi...

  19. 环境空气中臭氧API评价探讨%Study on Air Ozone API Evaluation

    Institute of Scientific and Technical Information of China (English)

    徐建平

    2012-01-01

    Air ozone API evaluation is considered that area of influence on ozone concentration exceed ambient air quality, ozone API correction on hours on ozone concentration exceed ambient air quality and Ozone average concentration exceed ambient air quality.%环境空气中臭氧API评价应考虑臭氧超标影响范围、臭氧超标小时数和超标平均浓度对臭氧API修正.

  20. The microsporidian Nosema ceranae, the antibiotic Fumagilin-B®, and western honey bee (Apis mellifera) colony strength

    OpenAIRE

    Williams, Geoffrey,; Shutler, Dave; Little, Catherine; Burgher-Maclellan, Karen; Rogers, Richard

    2011-01-01

    International audience Western honey bees (Apis mellifera) are under threat from a number of emerging pathogens, including the microsporidian Nosema ceranae historically of Asian honey bees (Apis cerana). Because of its recent detection, very little is known about the biology, pathology, and control of N. ceranae in western honey bees. Here we investigated effects of the antibiotic Fumagilin-B®, which is commonly used to control the historical Nosema parasite of western honey bees Nosema a...

  1. Isolation and characterization of P1 minireplicons, lambda-P1:5R and lambda-P1:5L.

    OpenAIRE

    Sternberg, N; Austin, S

    1983-01-01

    We have isolated two new classes of P1 miniplasmids, called lambda-P1:5R and lambda-P1:5L, by the in vivo extension of a cloned P1 fragment, EcoRI-5, which by itself is not capable of plasmid replication. The lambda-P1:5R plasmids contain EcoRI-5 plus a variable portion of the adjacent P1 EcoRI fragment 8. They have a copy number like that of P1 (about 1 per host chromosome), are faithfully segregated at cell division, and are subject to incompatibility exerted by either a single copy of P1 o...

  2. Overview of pressure-drawdown production-test results for the JAPEX/JNOC/GSC et al. Mallik 5L-38 gas hydrate production research well

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, S.H.; Carle, D.; Weatherill, B. [APA Petroleum Engineering Ltd., Calgary, AB (Canada); Dallimore, S.R. [Geological Survey of Canada, Pacific Geoscience Centre, Sidney, BC (Canada); Collett, T.S. [United States Geological Survey, Denver, CO (United States); Satoh, T. [Japan Petroleum Exploration Co. Ltd., Tokyo (Japan); Inoue, T. [Japan National Oil Corp., Chiba (Japan)

    2005-07-01

    Schlumberger's Modular Dynamic Tester (MDT) cased hole wireline tool was used during a pressure drawdown production test at the Mallik 5L-38 well to successfully test separate hydrate intervals as well as free gas and water zones. This paper provided an overview of the pressure-drawdown testing operations and results. Preliminary analysis of the gas hydrate porous-media response was also presented. Two important phenomena were observed during the hydrate tests: (1) free gas was produced on a steady state basis following the initial clean-up flow of water, and (2) the pressure response upon shut-in displayed porous media effects and indicated both flow contribution and pressure effects beyond the surface area of the hydrate open to the wellbore. Since analytical pressure transient analysis software cannot incorporate dynamic reservoir parameters, conventional analytical techniques were used to evaluate the test data.

  3. Mechanism of thermal ring closure of M(CO) sub 5 L (L = bidentate ligand) produced during photolysis of group 6 hexacarbonyl complexes

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, K.B.; van Eldik, R. (Univ. of Witten/Herdecke (West Germany))

    1990-05-01

    The kinetics of the thermal ring-closure reactions of M(CO){sub 5}L, produced during the photolysis of M(CO){sub 6}/L for L = ethylenediamine (en) and 1,4-diisopropyl-1,4-diazabutadiene (dab), were studied as a function of (L), temperature, and pressure. The values of {Delta}S{double dagger} and {Delta}V{double dagger} are significantly negative, {minus}40 to {minus}170 J K{sup {minus}1} mol{sup {minus}1} and {minus}5.4 to {minus}13.7 cm{sup 3} mol{sup {minus}1}, respectively, for M = Cr (L = en) and M = Mo, W (L = en, dab) and support an associative ring-closure mechanism. The results demonstrate the crucial role played by the size of the metal center and the steric hindrance on L.

  4. Opening the Door: A First Look at the OCLC WorldCat Metadata API

    Directory of Open Access Journals (Sweden)

    Terry Reese

    2014-07-01

    Full Text Available Libraries have long relied on OCLC’s WorldCat database as a way to cooperatively share bibliographic data and declare library holdings to support interlibrary loan services. As curator, OCLC has traditionally mediated all interactions with the WorldCat database through their various cataloging clients to control access to the information. As more and more libraries look for new ways to interact with their data and streamline metadata operations and workflows, these clients have become bottlenecks and an inhibitor of library innovation. To address some of these concerns, in early 2013 OCLC announced the release of a set of application programming interfaces (APIs supporting read and write access to the WorldCat database. These APIs offer libraries their first opportunity to develop new services and workflows that directly interact with the WorldCat database, and provide opportunities for catalogers to begin redefining how they work with OCLC and their data.

  5. Beginning the 21st century with advanced Automatic Parts Identification (API)

    Science.gov (United States)

    Schramm, Fred; Roxby, Don

    1994-01-01

    Under the direction of the NASA George C. Marshall Space Flight Center, Huntsville, Alabama, the development and commercialization of an advanced Automated Parts Indentification (API) system is being undertaken by Rockwell International Corporation. The new API system is based on a variable sized, machine-readable, two-dimensioanl matrix symbol that can be applied directly onto most metallic and nonmetallic materials using safe, permanent marking methods. Its checkerboard-like structure is the most space efficient of all symbologies. This high data-density symbology can be applied to products of different material sizes and geometries using application-dependent, computer-driven marking devices. The high fidelity markings produced by these devices can then be captured using a specially designed camera linked to any IBM-compatible computer. Applications of compressed symbology technology will reduce costs and improve quality, productivity, and processes in a wide variety of federal and commercial applications.

  6. TogoWS: integrated SOAP and REST APIs for interoperable bioinformatics Web services.

    Science.gov (United States)

    Katayama, Toshiaki; Nakao, Mitsuteru; Takagi, Toshihisa

    2010-07-01

    Web services have become widely used in bioinformatics analysis, but there exist incompatibilities in interfaces and data types, which prevent users from making full use of a combination of these services. Therefore, we have developed the TogoWS service to provide an integrated interface with advanced features. In the TogoWS REST (REpresentative State Transfer) API (application programming interface), we introduce a unified access method for major database resources through intuitive URIs that can be used to search, retrieve, parse and convert the database entries. The TogoWS SOAP API resolves compatibility issues found on the server and client-side SOAP implementations. The TogoWS service is freely available at: http://togows.dbcls.jp/.

  7. Fast Synchronization In IVR Using REST API For HTML5 And AJAX

    Directory of Open Access Journals (Sweden)

    Sandeep Kailuke,

    2014-09-01

    Full Text Available Need a web service is just a web page meant for a computer to request and process. IVR system uses REST API for data access while calling. When in call process user want to access data, server need to validate it and while validation data accessing must be synchronize with mysql server. For large data accessing API is essential. This method is for HTML5 and AJAX for fast data synchronization. REST can support any media type, but XML is expected to be the most popular transport for structured information. In IVR System problems with fast data access because before uses HTML4. Proposed work is for HTML5 with AJAX implementation.

  8. Developing a Digital Video Library with the YouTube Data API

    Directory of Open Access Journals (Sweden)

    Jason Clark

    2013-04-01

    Full Text Available MSU Library has created a digital video library using the YouTube API to power our local library channel. It is a complete search and browse application with item level views, microdata, a caching and optimization routine, and a file backup routine. The article will discuss applying the YouTube API as a database application layer: workflow efficiencies, metadata procedures and local backup and optimization procedures. Code samples in PHP, .htaccess examples, and shell commands used in developing the application and routines will be explained at length. And finally, a complete prototype application will be released on github for other libraries to get started using the lessons learned. A live version of the application is here: http://www.lib.montana.edu/channel/. The real benefit of this method is the low overhead for smaller shops and the ability to scale production and distribution of digital video.

  9. Comparative proteomic analysis reveals mite (Varroa destructor) resistance-related proteins in Eastern honeybees (Apis cerana).

    Science.gov (United States)

    Ji, T; Shen, F; Liu, Z; Yin, L; Shen, J; Liang, Q; Luo, Y X

    2015-08-21

    The mite (Varroa destructor) has become the greatest threat to apiculture worldwide. As the original host of the mite, Apis cerana can effectively resist the mite. An increased understanding of the resistance mechanisms of Eastern honeybees against V. destructor may help researchers to protect other species against these parasites. In this study, the proteomes of 4 Apis cerana colonies were analyzed using an isobaric tag for relative and absolute quantitation technology. We determined the differences in gene and protein expression between susceptible and resistant colonies that were either unchallenged or challenged by V. destructor. The results showed that a total of 1532 proteins were identified. Gene Ontology enrichment analysis suggested that the transcription factors and basic metabolic and respiratory processes were efficient and feasible factors controlling this resistance, and 12 differentially expressed proteins were identified in Venn analysis. The results were validated by quantitative polymerase chain reaction. This study may provide insight into the genetic mechanisms underlying the resistance of honeybee to mites.

  10. Temporal genetic structure of a drone congregation area of the giant Asian honeybee ( Apis dorsata)

    Science.gov (United States)

    Kraus, F. B.; Koeniger, N.; Tingek, S.; Moritz, R. F. A.

    2005-12-01

    The giant Asian honeybee ( Apis dorsata), like all other members of the genus Apis, has a complex mating system in which the queens and males (drones) mate at spatially defined drone congregation areas (DCAs). Here, we studied the temporal genetic structure of a DCA of A. dorsata over an 8-day time window by the genotyping of sampled drones with microsatellite markers. Analysis of the genotypic data revealed a significant genetic differentiation between 3 sampling days and indicated that the DCA was used by at least two subpopulations at all days in varying proportions. The estimation of the number of colonies which used the DCA ranged between 20 and 40 colonies per subpopulation, depending on the estimation procedure and population. The overall effective population size was estimated as high as N e=140. The DCA seems to counteract known tendencies of A. dorsata for inbreeding within colony aggregations by facilitating gene flow among subpopulations and increasing the effective population size.

  11. The Bo1-specific PCR marker AWW5L7 is predictive of boron tolerance status in a range of exotic durum and bread wheats.

    Science.gov (United States)

    Schnurbusch, Thorsten; Langridge, Peter; Sutton, Tim

    2008-12-01

    High soil boron (B) constitutes a major soil problem in many parts of the world, particularly in low-rainfall areas and land under irrigation. Low accumulation of B in the shoot or grain of cereal crops is correlated with the maintenance of biomass production and grain yield under high B conditions, suggesting that this trait is an important component of field tolerance. A novel screening protocol to measure B accumulation in aerated and supported hydroponics was validated using a set of known and exotic bread wheat (Triticum aestivum L.) and durum wheat (Triticum turgidum L. subsp. durum (Desf.) Husn.) accessions. Furthermore, B accumulation in two Triticum urartu Tumanian ex Gandilyan and 54 Triticum monococcum L. accessions was measured and showed considerable phenotypic variation. However, B accumulation in these lines was higher than that observed in the most tolerant durum or bread wheats. Mapping of high B tolerance in the durum population AUS14010/Yallaroi revealed a locus possibly allelic to Bo1, a major source of B toxicity tolerance previously identified in bread wheat. Here, we show that the Bo1-specific codominant PCR marker AWW5L7 is predictive of B tolerance status among exotic durum and bread wheat accessions. All tolerant durum accessions assayed carried very similar AWW5L7 marker fragments, indicating wide distribution of this allele among tolerant durum wheats. Three bread wheat accessions had tolerance that was independent of Bo1 and is probably located on chromosome 4A. These lines represent a valuable genetic resource for B toxicity tolerance breeding in wheat. PMID:19088810

  12. Speeding up the solar water disinfection process (SODIS) against Cryptosporidium parvum by using 2.5l static solar reactors fitted with compound parabolic concentrators (CPCs).

    Science.gov (United States)

    Gómez-Couso, H; Fontán-Sainz, M; Fernández-Ibáñez, P; Ares-Mazás, E

    2012-12-01

    Water samples of 0, 5, and 100 nephelometric turbidity units (NTU) spiked with Cryptosporidium parvum oocysts were exposed to natural sunlight in 2.5l static borosilicate solar reactors fitted with two different compound parabolic concentrators (CPCs), CPC1 and CPC1.89, with concentration factors of the solar radiation of 1 and 1.89, respectively. The global oocyst viability was calculated by the evaluation of the inclusion/exclusion of the fluorogenic vital dye propidium iodide and the spontaneous excystation. Thus, the initial global oocyst viability of the C. parvum isolate used was 95.3 ± 1.6%. Using the solar reactors fitted with CPC1, the global viability of oocysts after 12h of exposure was zero in the most turbid water samples (100 NTU) and almost zero in the other water samples (0.3 ± 0.0% for 0 NTU and 0.5 ± 0.2% for 5 NTU). Employing the solar reactors fitted with CPC1.89, after 10h exposure, the global oocyst viability was zero in the non-turbid water samples (0 NTU), and it was almost zero in the 5 NTU water samples after 8h of exposure (0.5 ± 0.5%). In the most turbid water samples (100 NTU), the global viability was 1.9 ± 0.6% after 10 and 12h of exposure. In conclusion, the use of these 2.5l static solar reactors fitted with CPCs significantly improved the efficacy of the SODIS technique as these systems shorten the exposure times to solar radiation, and also minimize the negative effects of turbidity. This technology therefore represents a good alternative method for improving the microbiological quality of household drinking water in developing countries.

  13. csd alleles in the red dwarf honey bee (Apis florea,Hymenoptera: Apidae) show exceptionally high nucleotide diversity

    Institute of Scientific and Technical Information of China (English)

    Zhi-Yong Liu; Zi-Long Wang; Xiao-Bo Wu; Wei-Yu Yan; Zhi-Jiang Zeng

    2011-01-01

    The single locus complementary sex determination (sl-csd) gene is the primary gene determining the gender of honey bees (Apis spp.).While the csd gene has been well studied in the Western honey bee (Apis mellifera),and comparable data exist in both the Eastern honey bee (Apis cerana) and the giant honey bee (Apis dorsata),no studies have been conducted in the red dwarf honey bee,Apisflorea.In this study we cloned the genomic region 3 of the A.florea csd gene from 60 workers,and identified 12 csd alleles.Analysis showed that similar to A.mellifera,region 3 of the csd gene contains a RS domain at the N terminal,a proline-rich domain at the C terminal,and a hypervariable region in the middle.However,the A.florea csd gene possessed a much higher level of nucleotide diversity,compared to A.mellifera,A.cerana and Apis dorsata.We also show that similar to the other three Apis species,in A.florea,nonsynonymous mutations in the csd gene are selectively favored in young alleles.

  14. Efeitos de atrativos e repelentes sobre o comportamento da abelha (Apis mellifera, l. Effect of attractants and repellents on the behavior of honey bees (Apis mellipera, L.

    Directory of Open Access Journals (Sweden)

    D.T. MALERBO-SOUZA

    1998-01-01

    Full Text Available O objetivo do presente ensaio foi testar diversas substâncias e verificar sua atratividade e repelência para abelhas, Apis mellifera, L. Para isso, foram realizados testes em discos próximos às colméias e em cana picada oferecida como alimentação para gado bovino confinado. Nos discos próximos à colméia, o produto mais atrativo foi Bee-Here e o mais repelente foi o óleo de citronela. No cocho para bovinos, o repelente mais efetivo foi n-octyl-acetato.The experiment aimed to study honey bee (Apis mellifera attractants and repellents in vitro and on chopped sugar cane for bovine feeding. Tests were performed on plates located near to the hives and on bovine-hods. On plates, Bee-Here® was the most attractive and citronela oil the most repellent. On bovine-hods the most effective was n-octyl-acetate.

  15. The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera

    OpenAIRE

    Jones, Andrew K.; Raymond-Delpech, Valerie; Steeve H Thany; Gauthier, Monique; Sattelle, David B.

    2006-01-01

    Nicotinic acetylcholine receptors (nAChRs) mediate fast cholinergic synaptic transmission and play roles in many cognitive processes. They are under intense research as potential targets of drugs used to treat neurodegenerative diseases and neurological disorders such as Alzheimer's disease and schizophrenia. Invertebrate nAChRs are targets of anthelmintics as well as a major group of insecticides, the neonicotinoids. The honey bee, Apis mellifera, is one of the most beneficial insects worldw...

  16. Galenics: studies of the toxicity and distribution of sugar substitutes on Apis mellifera

    OpenAIRE

    RADEMACHER, Eva; Fahlberg, Anja; Raddatz, Marlene; Schneider, Saskia; Voigt, Kathrin

    2013-01-01

    International audience The aim of this study was to find a substitute to sugar water in medicinal treatments of honey bee colonies with the same properties but without being ingested by bees or being toxic to them. Tylose MH, sorbitol and glycerol were tested for their attractiveness to Apis mellifera, their application ability, toxicity via individual application and distribution in small groups respectively a small colony. Neither of the substances proved attractive or toxic. All had goo...

  17. Residual solvent determination by head space gas chromatography with flame ionization detector in omeprazole API

    OpenAIRE

    Saurabh Pandey; Preeti Pandey; Raj Kumar; Narendra Pal Singh

    2011-01-01

    Residual solvents in pharmaceutical samples are monitored using gas chromatography with head space. Based on good manufacturing practices, measuring residual solvents is mandatory for the release testing of all active pharmaceutical ingredients (API). The analysis of residual organic solvents (methanol, acetone, cyclohexane, dichloromethane, toluene) in Omeprazole, an active pharmaceutical ingredient was investigated. Omeprazole is a potent reversible inhibitor of the gastric proton pump H+/K...

  18. An Efficient Data Indexing Approach on Hadoop Using Java Persistence API

    OpenAIRE

    Lai, Yang; ZhongZhi, Shi

    2010-01-01

    Data indexing is common in data mining when working with high-dimensional, large-scale data sets. Hadoop, a cloud computing project using the MapReduce framework in Java, has become of significant interest in distributed data mining. To resolve problems of globalization, random-write and duration in Hadoop, a data indexing approach on Hadoop using the Java Persistence API (JPA) is elaborated in the implementation of a KD-tree algorithm on Hadoop. An improved intersection algorithm for distrib...

  19. Manipulating API and AOD data to distinguish transportation of aerosol at high altitude in Penang, Malaysia

    International Nuclear Information System (INIS)

    Air pollution index (API) is an index commonly used in Malaysia to determine the air quality level. It is a ground truth data measurement which is unable to unambiguously quantify air quality level at higher atmosphere. On the other hand, aerosol optical depth (AOD) from AERONET data obtained using sun photometer provides reading of the air quality for a column of atmosphere from ground surface. We first determine the quantitative correlation between the API and AOD data collected in Penang, Malaysia, between January – September, 2012, using two independent methods, one based on regression analysis and the other interpolation. Our purpose is to establish a systematic numerical procedure to determine whether aerosol transported in high altitude from other location has occurred. Two independent methods for establishing the quantitative relationship between the API and AOD data were used as a way to facilitate the verification of our approach. In our method, data from southwest monsoon period (August to September) were used as ''calibration dataset'' to establish the quantitative correlation between the AOD and API data. The established calibrated coefficients is then used to predict the AOD of other months, which are then compared against the data actually measured. Discrepancy between the predicted and measured AOD data can then be interpreted as an indication of whether the atmosphere at high altitude is polluted by aerosol transported from other location. If the predicted AOD is much larger than that measured, back trajectory analysis was applied to identify the aerosol transported source. This procedure is very helpful to investigate the aerosol transportation and distribution patterns during monsoon and non monsoon periods

  20. Function and distribution of 5-HT2 receptors in the honeybee (Apis mellifera)

    OpenAIRE

    Markus Thamm; Daniel Rolke; Nadine Jordan; Sabine Balfanz; Christian Schiffer; Arnd Baumann; Wolfgang Blenau

    2013-01-01

    BACKGROUND: Serotonin plays a pivotal role in regulating and modulating physiological and behavioral processes in both vertebrates and invertebrates. In the honeybee (Apis mellifera), serotonin has been implicated in division of labor, visual processing, and learning processes. Here, we present the cloning, heterologous expression, and detailed functional and pharmacological characterization of two honeybee 5-HT2 receptors. METHODS: Honeybee 5-HT2 receptor cDNAs were amplified from brain cDNA...

  1. Molekulare und pharmakologische Charakterisierung von Serotonin-Rezeptoren der Honigbiene Apis mellifera

    OpenAIRE

    Schlenstedt, Jana

    2006-01-01

    Die Honigbiene Apis mellifera gilt seit langem als Modell-Organismus zur Untersuchung von Lern- und Gedächtnisvorgängen sowie zum Studium des Sozialverhaltens und der Arbeitsteilung. Bei der Steuerung und Regulation dieser Verhaltensweisen spielt das Indolalkylamin Serotonin eine wesentliche Rolle. Serotonin entfaltet seine Wirkung durch die Bindung an G-Protein-gekoppelte Rezeptoren (GPCRs). In der vorliegenden Arbeit wird der erste Serotonin-Rezeptor aus der Honigbiene molekular charakteris...

  2. Gut Pathology and Responses to the Microsporidium Nosema ceranae in the Honey Bee Apis mellifera

    OpenAIRE

    Claudia Dussaubat; Jean-Luc Brunet; Mariano Higes; Colbourne, John K.; Jacqueline Lopez; Jeong-Hyeon Choi; Raquel Martín-Hernández; Cristina Botías; Marianne Cousin; Cynthia McDonnell; Marc Bonnet; Luc P Belzunces; Moritz, Robin F.A.; Yves Le Conte; Cédric Alaux

    2012-01-01

    The microsporidium Nosema ceranae is a newly prevalent parasite of the European honey bee (Apis mellifera). Although this parasite is presently spreading across the world into its novel host, the mechanisms by it which affects the bees and how bees respond are not well understood. We therefore performed an extensive characterization of the parasite effects at the molecular level by using genetic and biochemical tools. The transcriptome modifications at the midgut level were characterized seve...

  3. Characterization of an Unusually Conserved Alui Highly Reiterated DNA Sequence Family from the Honeybee, Apis Mellifera

    OpenAIRE

    Tares, S.; Cornuet, J. M.; Abad, P.

    1993-01-01

    An AluI family of highly reiterated nontranscribed sequences has been found in the genome of the honeybee Apis mellifera. This repeated sequence is shown to be present at approximately 23,000 copies per haploid genome constituting about 2% of the total genomic DNA. The nucleotide sequence of 10 monomers was determined. The consensus sequence is 176 nucleotides long and has an A + T content of 58%. There are clusters of both direct and inverted repeats. Internal subrepeating units ranging from...

  4. Eph Receptor and Ephrin Signaling in Developing and Adult Brain of the Honeybee (Apis mellifera)

    OpenAIRE

    Vidovic, Maria; Nighorn, Alan; Koblar, Simon; Maleszka, Ryszard

    2007-01-01

    Roles for Eph receptor tyrosine kinase and ephrin signaling in vertebrate brain development are well established. Their involvement in the modulation of mammalian synaptic structure and physiology is also emerging. However, less is known of their effects on brain development and their function in adult invertebrate nervous systems. Here, we report on the characterization of Eph receptor and ephrin orthologs in the honeybee, Apis mellifera (Am), and their role in learning and memory. In situ h...

  5. Early Years of Serikat Buruh Kereta Api (Railway Workers Union, SBKA): Formation and Orientation

    OpenAIRE

    SURYOMENGGOLO, Jafar

    2008-01-01

    This essay describes the formation of Serikat Buruh Kereta Api (Railway Workers Union, SBKA) and its early orientation during the Indonesian revolution period of 1945-1950. SBKA originated from workers committees formed by groups of labour with nationalistic enthusiasm in order to secure the take-over process for independence. Later this committee was transformed into a union in response to government policies. Based on this description, this essay shows how the formation of unions at that pe...

  6. How Varroa Parasitism Affects the Immunological and Nutritional Status of the Honey Bee, Apis mellifera

    OpenAIRE

    Katherine A. Aronstein; Eduardo Saldivar; Rodrigo Vega; Stephanie Westmiller; Douglas, Angela E.

    2012-01-01

    We investigated the effect of the parasitic mite Varroa destructor on the immunological and nutritional condition of honey bees, Apis mellifera, from the perspective of the individual bee and the colony. Pupae, newly-emerged adults and foraging adults were sampled from honey bee colonies at one site in S. Texas, USA. Varroa‑infested bees displayed elevated titer of Deformed Wing Virus (DWV), suggestive of depressed capacity to lim...

  7. Characteristics of honey bee colonies (Apis mellifera) in Sweden surviving Varroa destructor infestation

    OpenAIRE

    Locke, Barbara; Fries, Ingemar

    2011-01-01

    International audience A population of European honey bees (Apis mellifera) surviving Varroa destructor mite infestation in Sweden for over 10 years without treatment, demonstrate that a balanced host-parasite relationship may evolve over time. Colony-level adaptive traits linked to Varroa tolerance were investigated in this population to identify possible characteristics that may be responsible for colony survival in spite of mite infestations. Brood removal rate, adult grooming rate, and...

  8. Viral epidemiology of the adult Apis Mellifera infested by the Varroa destructor mite

    OpenAIRE

    Bernardi, Sara; Venturino, Ezio

    2015-01-01

    The ectoparasitic mite Varroa destructor has become one of the major worldwide threats for apiculture. Varroa destructor attacks the honey bee Apis mellifera weakening its host by sucking hemolymph. However, the damage to bee colonies is not strictly related to the parasitic action of the mite but it derives, above all, from its action as vector increasing the trasmission of many viral diseases such as acute paralysis (ABPV) and deformed wing viruses (DWV), that are considered among the main ...

  9. Morphometric identification of queens, workers, intermediates in in vitro reared honey bees (Apis mellifera)

    OpenAIRE

    De Souza, Daiana A.; Ying Wang; Osman Kaftanoglu; David De Jong; Amdam, Gro V.; Lionel S. Gonçalves; Francoy, Tiago M.

    2015-01-01

    In vitro rearing is an important and useful tool for honey bee (Apis mellifera L.) studies. However, it often results in intercastes between queens and workers, which are normally are not seen in hive-reared bees, except when larvae older than three days are grafted for queen rearing. Morphological classification (queen versus worker or intercastes) of bees produced by this method can be subjective and generally depends on size differences. Here, we propose an alternative method for caste cla...

  10. Studies of the eddy structure in the lower ionosphere by the API technique

    Science.gov (United States)

    Bakhmetieva, Nataliya V.; Grigoriev, Gennadii I.; Lapin, Victor G.

    2016-07-01

    We present a new application of the API technique to study of turbulent phenomena in the lower ionosphere. The main objective of these studies is experimental diagnostics of natural ordered eddy structures at the altitudes of the mesosphere and lower thermosphere, such as those that occur when internal gravity waves propagate in stratified flows in the atmospheric boundary layer. To this end, we considered the impact of eddy motions in the mesosphere and lower thermosphere on the relaxation time and the frequency of the signal scattered by periodic irregularities. Theoretical study of eddy structures base on experiments using SURA heating facility (56,14 N; 44,1 W). It is known, artificial periodic irregularities (APIs) are formed in the field of the powerful standing wave as a result of the interference of the incident wave and reflected from the ionosphere (Belikovich et al., Ionospheric Research by Means of Artificial Periodic Irregularities - 2002. Katlenburg-Lindau, Germany. Copernicus GmbH. 160 p.). The relaxation or decay of the periodic structure is specified by the ambipolar diffusion process. The atmospheric turbulence causes reduction of the amplitude and decay time of the API scattered signal in comparison with the diffusion time. We found a relation between the eddy period and the characteristic decay time of scattered signal, for which the synchronism of the waves scattered by a periodic structure is broken. Besides, it is shown, when the eddy structure moves by a horizontal wind exists at these heights, the frequency of the radio wave scattered by API structure will periodically increase and decrease compared with the frequency of the radiated diagnostic (probing) radio-wave. The work was supported by the Russian Science Foundation under grant No 14-12-00556.

  11. Comparative Toxicities and Synergism of Apple Orchard Pesticides to Apis mellifera (L.) and Osmia cornifrons (Radoszkowski)

    OpenAIRE

    Biddinger, David J.; Jacqueline L Robertson; Chris Mullin; James Frazier; Ashcraft, Sara A.; Edwin G Rajotte; Joshi, Neelendra K.; Mace Vaughn

    2013-01-01

    The topical toxicities of five commercial grade pesticides commonly sprayed in apple orchards were estimated on adult worker honey bees, Apis mellifera (L.) (Hymenoptera: Apidae) and Japanese orchard bees, Osmia cornifrons (Radoszkowski) (Hymenoptera: Megachilidae). The pesticides were acetamiprid (Assail 30SG), λ-cyhalothrin (Warrior II), dimethoate (Dimethoate 4EC), phosmet (Imidan 70W), and imidacloprid (Provado 1.6F). At least 5 doses of each chemical, diluted in distilled water, were app...

  12. Non-lethal sampling of honey bee, Apis mellifera, DNA using wing tips

    OpenAIRE

    Chaline, N.; F.L.W. Ratnieks; Raine, N. E.; Badcock, N.S.; Burke, T

    2004-01-01

    DNA sampling of insects frequently relies upon lethal or invasive methods. Because insect colonies contain numerous workers it is often possible to destructively sample workers for genetic analysis. However, this is not possible if queens or workers must remain alive after sampling. Neither is it possible to remove an entire leg, wing or other appendage as this will often hinder normal behaviour. This study investigates the possibility of genotyping queen honey bees Apis mellifera using DNA e...

  13. Differential insecticide susceptibility of the Neotropical stingless bee Melipona quadrifasciata and the honey bee Apis mellifera

    OpenAIRE

    Sarto, Mário; Oliveira, Eugênio; Guedes,Raul; Campos, Lúcio

    2014-01-01

    International audience The toxicity of three insecticides frequently used in Neotropical tomato cultivation (abamectin, deltamethrin, and methamidophos) was estimated on foragers of the Neotropical stingless bee Melipona quadrifasciata (Lep.) and the honey bee Apis mellifera (L.). Our results showed that the susceptibility varied significantly with the type of exposure (ingestion, topical, or contact), and there were significant differences between species. While M. quadrifasciata was usua...

  14. Influence of processing in the physicochemical quality of Apis mellifera honey from Mato Grosso State, Brazil

    OpenAIRE

    Karina Renostro DUCATTI; Carmen WOBETO; Juliana Aparecida da SILVA; Claudineli Cássia Bueno da ROSA; Márcio Roggia ZANUZO; Angelo POLIZEL NETO

    2014-01-01

    Objective: In this study, the quality of the Apis mellifera honey produced by 12 beekeepers from four associations in the north of Mato Grosso state was investigated during processing, Materials and Methods: The samples were collected at three different stages of processing: a) in the honeycomb at the honey house reception (S1), b) after centrifugation (S2), c) after packaging (S3), The levels of free acidity, moisture, ash, insoluble solids, diastase activity, hydroxymethylfurfural, reducing...

  15. The Occurrence of Varroa destructor Anderson and Trueman, 2000 on Honey Bees (Apis mellifera) in Turkey

    OpenAIRE

    Aydin, Levent; GÜLEĞEN, Ender; ÇAKMAK, İbrahim; GİRİŞGİN, A. Onur

    2007-01-01

    The mite formerly known as Varroa jacobsoni is one of the major problems in beekeeping worldwide. Recently, it was shown that this pest is not V. jacobsoni, which chiefly infests the nests of Apis cerana in the Malaysia-Indonesia region, and the widespread pest was recognized with the new name, V. destructor. Morphometric analysis was performed on collected Varroa specimens from various regions in Turkey and identified as V. destructor.

  16. Viral Infection Affects Sucrose Responsiveness and Homing Ability of Forager Honey Bees, Apis mellifera L.

    OpenAIRE

    Zhiguo Li; Yanping Chen; Shaowu Zhang; Shenglu Chen; Wenfeng Li; Limin Yan; Liangen Shi; Lyman Wu; Alex Sohr; Songkun Su

    2013-01-01

    Honey bee health is mainly affected by Varroa destructor, viruses, Nosema spp., pesticide residues and poor nutrition. Interactions between these proposed factors may be responsible for the colony losses reported worldwide in recent years. In the present study, the effects of a honey bee virus, Israeli acute paralysis virus (IAPV), on the foraging behaviors and homing ability of European honey bees (Apis mellifera L.) were investigated based on proboscis extension response (PER) assays and ra...

  17. Use of oxalic acid to control Varroa destructor in honeybee (Apis mellifera L.) colonies

    OpenAIRE

    AKYOL, Ethem; YENİNAR, Halil

    2009-01-01

    This study was carried out to determine the effects of oxalic acid (OA) on reducing Varroa mite (Varroa destructor) populations in honeybee (Apis mellifera L.) colonies in the fall. Twenty honeybee colonies, in wooden Langstroth hives, were used in this experiment. Average Varroa infestation levels (%) of the OA and control groups were 25.87% and 24.57% on adult workers before the treatments. The OA treatments were applied twice, on 3 November and 13 November 2006. Average Varroa infestation ...

  18. An analysis of the intrinsic cross-correlations between API and meteorological elements using DPCCA

    Science.gov (United States)

    Shen, Chen-hua; Li, Cao-ling

    2016-03-01

    In order to reveal the intrinsic cross-correlations between air pollution index (API) records and synchronously meteorological elements data, the detrended partial cross-correlation (DPCC) coefficients are analyzed using a detrended partial cross-correlation analysis (DPCCA). DPCC coefficients for different spatial locations and seasons are calculated and compared. The results show that DPCCA can uncover intrinsic cross-correlations between API and meteorological elements, and most of their interactional mechanisms can be explained. DPCC coefficients are either positive or negative, and vary with spatial locations and seasons, with consistently interactional mechanisms. More remarkable, we find that detrended cross-correlation analysis can present the cross-correlations between the fluctuations in two nonstationary time series, but this cross-correlation does not always fully reflect the interactional mechanism for the original time series. Despite this, DPCCA is recommended as a comparatively reliable method for revealing intrinsic cross-correlations between API and meteorological elements, and it can also be useful for our understanding of their interactional mechanisms.

  19. A comparative study of relational learning capacity in honeybees (Apis mellifera and stingless bees (Melipona rufiventris.

    Directory of Open Access Journals (Sweden)

    Antonio Mauricio Moreno

    Full Text Available BACKGROUND: Learning of arbitrary relations is the capacity to acquire knowledge about associations between events or stimuli that do not share any similarities, and use this knowledge to make behavioural choices. This capacity is well documented in humans and vertebrates, and there is some evidence it exists in the honeybee (Apis mellifera. However, little is known about whether the ability for relational learning extends to other invertebrates, although many insects have been shown to possess excellent learning capacities in spite of their small brains. METHODOLOGY/PRINCIPAL FINDINGS: Using a symbolic matching-to-sample procedure, we show that the honeybee Apis mellifera rapidly learns arbitrary relations between colours and patterns, reaching 68.2% correct choice for pattern-colour relations and 73.3% for colour-pattern relations. However, Apis mellifera does not transfer this knowledge to the symmetrical relations when the stimulus order is reversed. A second bee species, the stingless bee Melipona rufiventris from Brazil, seems unable to learn the same arbitrary relations between colours and patterns, although it exhibits excellent discrimination learning. CONCLUSIONS/SIGNIFICANCE: Our results confirm that the capacity for learning arbitrary relations is not limited to vertebrates, but even insects with small brains can perform this learning task. Interestingly, it seems to be a species-specific ability. The disparity in relational learning performance between the two bee species we tested may be linked to their specific foraging and recruitment strategies, which evolved in adaptation to different environments.

  20. CernVM WebAPI - Controlling Virtual Machines from the Web

    Science.gov (United States)

    Charalampidis, I.; Berzano, D.; Blomer, J.; Buncic, P.; Ganis, G.; Meusel, R.; Segal, B.

    2015-12-01

    Lately, there is a trend in scientific projects to look for computing resources in the volunteering community. In addition, to reduce the development effort required to port the scientific software stack to all the known platforms, the use of Virtual Machines (VMs)u is becoming increasingly popular. Unfortunately their use further complicates the software installation and operation, restricting the volunteer audience to sufficiently expert people. CernVM WebAPI is a software solution addressing this specific case in a way that opens wide new application opportunities. It offers a very simple API for setting-up, controlling and interfacing with a VM instance in the users computer, while in the same time offloading the user from all the burden of downloading, installing and configuring the hypervisor. WebAPI comes with a lightweight javascript library that guides the user through the application installation process. Malicious usage is prohibited by offering a per-domain PKI validation mechanism. In this contribution we will overview this new technology, discuss its security features and examine some test cases where it is already in use.