Layered ACO-OFDM for intensity-modulated direct-detection optical wireless transmission.

Science.gov (United States)

Wang, Qi; Qian, Chen; Guo, Xuhan; Wang, Zhaocheng; Cunningham, David G; White, Ian H

2015-05-04

Layered asymmetrically clipped optical orthogonal frequency division multiplexing (ACO-OFDM) with high spectral efficiency is proposed in this paper for optical wireless transmission employing intensity modulation with direct detection. In contrast to the conventional ACO-OFDM, which only utilizes odd subcarriers for modulation, leading to an obvious spectral efficiency loss, in layered ACO-OFDM, the subcarriers are divided into different layers and modulated by different kinds of ACO-OFDM, which are combined for simultaneous transmission. In this way, more subcarriers are used for data transmission and the spectral efficiency is improved. An iterative receiver is also proposed for layered ACO-OFDM, where the negative clipping distortion of each layer is subtracted once it is detected so that the signals from different layers can be recovered. Theoretical analysis shows that the proposed scheme can improve the spectral efficiency by up to 2 times compared with conventional ACO-OFDM approaches with the same modulation order. Meanwhile, simulation results confirm a considerable signal-to-noise ratio gain over ACO-OFDM at the same spectral efficiency.

Tailoring Systems Engineering Processes in a Conceptual Design Environment: A Case Study at NASA Marshall Spaceflight Center's ACO

Science.gov (United States)

Mulqueen, John; Maples, C. Dauphne; Fabisinski, Leo, III

2012-01-01

This paper provides an overview of Systems Engineering as it is applied in a conceptual design space systems department at the National Aeronautics and Space Administration (NASA) Marshall Spaceflight Center (MSFC) Advanced Concepts Office (ACO). Engineering work performed in the NASA MFSC's ACO is targeted toward the Exploratory Research and Concepts Development life cycle stages, as defined in the International Council on Systems Engineering (INCOSE) System Engineering Handbook. This paper addresses three ACO Systems Engineering tools that correspond to three INCOSE Technical Processes: Stakeholder Requirements Definition, Requirements Analysis, and Integration, as well as one Project Process Risk Management. These processes are used to facilitate, streamline, and manage systems engineering processes tailored for the earliest two life cycle stages, which is the environment in which ACO engineers work. The role of systems engineers and systems engineering as performed in ACO is explored in this paper. The need for tailoring Systems Engineering processes, tools, and products in the ever-changing engineering services ACO provides to its customers is addressed.

Determinants of success in Shared Savings Programs: An analysis of ACO and market characteristics.

Science.gov (United States)

Ouayogodé, Mariétou H; Colla, Carrie H; Lewis, Valerie A

2017-03-01

Medicare's Accountable Care Organization (ACO) programs introduced shared savings to traditional Medicare, which allow providers who reduce health care costs for their patients to retain a percentage of the savings they generate. To examine ACO and market factors associated with superior financial performance in Medicare ACO programs. We obtained financial performance data from the Centers for Medicare and Medicaid Services (CMS); we derived market-level characteristics from Medicare claims; and we collected ACO characteristics from the National Survey of ACOs for 215 ACOs. We examined the association between ACO financial performance and ACO provider composition, leadership structure, beneficiary characteristics, risk bearing experience, quality and process improvement capabilities, physician performance management, market competition, CMS-assigned financial benchmark, and ACO contract start date. We examined two outcomes from Medicare ACOs' first performance year: savings per Medicare beneficiary and earning shared savings payments (a dichotomous variable). When modeling the ACO ability to save and earn shared savings payments, we estimated positive regression coefficients for a greater proportion of primary care providers in the ACO, more practicing physicians on the governing board, physician leadership, active engagement in reducing hospital re-admissions, a greater proportion of disabled Medicare beneficiaries assigned to the ACO, financial incentives offered to physicians, a larger financial benchmark, and greater ACO market penetration. No characteristic of organizational structure was significantly associated with both outcomes of savings per beneficiary and likelihood of achieving shared savings. ACO prior experience with risk-bearing contracts was positively correlated with savings and significantly increased the likelihood of receiving shared savings payments. In the first year, performance is quite heterogeneous, yet organizational structure does not

The asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): opportunities and challenges.

Science.gov (United States)

Barrecheguren, Miriam; Esquinas, Cristina; Miravitlles, Marc

2015-01-01

Some individuals share characteristics of asthma and chronic obstructive pulmonary disease (COPD). The asthma-COPD overlap syndrome (ACOS) has been defined as symptoms of increased variability of airflow in association with an incompletely reversible airflow obstruction. In this review, we present the latest findings in the diagnosis, characterization and management of ACOS. Around 15-20% of COPD patients may have an ACOS. Patients with ACOS are characterized by increased reversibility of airflow obstruction, eosinophilic bronchial and systemic inflammation, and increased response to inhaled corticosteroids, compared with the remaining patients with COPD. Patients with ACOS have more frequent exacerbations, more wheezing and dyspnoea, but similar cough and sputum production compared with COPD. The relevance of the ACOS is to identify patients with COPD who may have underlying eosinophilic inflammation that responds to inhaled corticosteroids. So far, the previous diagnosis of asthma in a patient with COPD is the more reliable criterion for ACOS. Ongoing studies will clarify if concentrations of blood eosinophils may be useful to identify this subgroup of patients with COPD. If this is the case, the interest of ACOS may shift to that of eosinophilic COPD, which is easier to diagnose and has clear therapeutic implications.

Feocromocitoma cardíaco

Directory of Open Access Journals (Sweden)

Gustavo L. Knop

2006-01-01

Full Text Available Los feocromocitomas cardíacos primarios (FCP son sumamente infrecuentes. Hasta el presente son menos de 50 los casos comunicados en el mundo. Presentamos el caso de un tumor intrapericárdico, que resultó ser un feocromocitoma primario, en una mujer de mediana edad, cuyo signo principal fue hipertensión arterial severa (HTAs. Los estudios diagnósticos por imágenes corroboraron la presencia de un tumor intrapericárdico como único hallazgo y los estudios bioquímicos de catecolaminas y sus metabolitos excretados por orina reafirmaron el diagnóstico etiológico. El tumor fue resecado quirúrgicamente sin complicaciones mediante cirugía cardíaca convencional con circulación extracorpórea (CEC y paro cardíaco con cardioplejía. Siete meses después de la operación, la paciente se encuentra asintomática y normotensa.

Paro Cardíaco en el Embarazo

OpenAIRE

Manuel Eduardo Sáenz Madrigal; Carlos Adrián Vindas Morera

2013-01-01

El paro cardíaco en el embarazo presenta un escenario único en el que están incluidos dos pacientes: la madre y el feto. El manejo de este escenario requiere de un equipo multidisciplinario incluyendo especialistas en anestesia, obstetricia, neonatología, cardiología y en ocasiones cirugía cardíaca. Los protocolos de soporte vital básico y soporte cardíaco avanzado deben ser implementados, sin embargo, dados los cambios anatómicos y fisiológicos que ocurren en el embarazo, algunas modificacio...

24 CFR 965.508 - Individual relief.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Individual relief. 965.508 Section 965.508 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... PHA-OWNED OR LEASED PROJECTS-GENERAL PROVISIONS Resident Allowances for Utilities § 965.508 Individual...

Critical cleavage fracture stress characterization of A508 nuclear pressure vessel steels

International Nuclear Information System (INIS)

Wu, Sujun; Jin, Huijin; Sun, Yanbin; Cao, Luowei

2014-01-01

The critical cleavage fracture stress of SA508 Gr.4N and SA508 Gr.3 low alloy reactor pressure vessel (RPV) steels was studied through the combination of experiments and finite element method (FEM) analysis. The results showed that the value of the local cleavage fracture stress, σ F , of SA508 Gr.4N steel was significantly higher than that of SA508 Gr.3 steel. Detailed microstructural analysis was carried out using FEGSEM which revealed much smaller grains, finer and more homogenous carbide particles formed in SA508 Gr.4N steel. Compared with the SA508 Gr.3 steel currently used in the nuclear industry, the SA508 Gr.4N steel possesses higher strength and notch toughness as well as improved cleavage fracture behavior, and is considered a better candidate RPV steel for the next generation nuclear reactors. - Highlights: • Critical cleavage fracture stress was calculated through experiments and FEM. • Effects of both grain and carbide particle sizes on σ F were discussed. • The SA508 Gr.4N steel is a better candidate for the next generation nuclear reactors

7 CFR 1207.508 - USDA costs.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false USDA costs. 1207.508 Section 1207.508 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Rules and Regulations General § 1207.508 USDA costs. Pursuant to § 1207.341 of the Plan the Board shall...

12 CFR 508.10 - Burden of persuasion.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Burden of persuasion. 508.10 Section 508.10 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.10 Burden of persuasion. The petitioner has the burden of...

Fracture toughness of welded joints of ASTM A543 steel plate

International Nuclear Information System (INIS)

Susukida, H.; Uebayashi, T.; Yoshida, K.; Ando, Y.

1977-01-01

Fracture toughness and weldability tests have been performed on a high strength steel which is a modification of ASTM A543 Grade B Class 1 steel, with a view to using it for nuclear reactor containment vessels. The results showed that fracture toughness of welded joints of ASTM A543 modified high strength steel is superior and the steel is suitable for manufacturing the containment vessels

Super ACO FEL oscillation at 300 nm

CERN Document Server

Nutarelli, D; Renault, E; Nahon, L; Couprie, Marie Emmanuelle

2000-01-01

Some recent improvements, involving both the optical cavity mirrors and the positron beam dynamics in the storage ring, have allowed us to achieve a laser oscillation at 300 nm on the Super ACO Storage Ring FEL. The Super ACO storage ring is operated at 800 MeV which is the nominal energy for the usual synchrotron radiation users, and the highest energy for a storage ring FEL. The lasing at 300 nm could be kept during 2 h per injection, with a stored current ranging between 30 and 60 mA. The FEL characteristics are presented here. The longitudinal stability and the FEL optics behaviour are also discussed.

ETC 408/508: Technical Editing

Science.gov (United States)

Charlton, Michael

2013-01-01

ETC 408/508: Technical Editing is a cross-listed undergraduate and graduate course at Missouri Western State University, an open admissions public university with approximately 6,000 students. 508 is an elective course for students in the Master of Applied Arts in Written Communication degree and highly recommended for those in the Technical…

9 CFR 93.508 - Articles accompanying swine.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Articles accompanying swine. 93.508 Section 93.508 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Swine § 93.508 Articles accompanying swine. No litter...

Comparison of ASTM D613 and ASTM D6890

Science.gov (United States)

2016-04-01

cetane values outside of the routine range of traditional CN testing by ASTM D613, this is an important advantage in fuel blending and disposition...Number testing. Particular emphasis was placed on evaluating fuels, and blends thereof, having cetane values outside of the normal range of the...interest covers both petroleum-based and synthetic-based, as well as blends thereof in order to improve the confidence in using DCN as a replacement

A-508 class 3 forgings for pressure vessels

International Nuclear Information System (INIS)

Comon, J.

1977-01-01

The manufacture of the forged parts of the first PWR nuclear pressure vessel installed in France started in the Creusot-Loire's Forge Plant in 1961. Since this date, more than 300 forgings of this type were delivered (flanges, rings, zones, and nozzles). The major part of these forgings were made of Mn, Ni, Mo steel (SA 508 class 3). They represent a population large and homogeneous enough to attempt a statistical analysis of chemical and mechanical test results. The aim of this analysis was double: (1) a better knowledge of the scattering of the results and a better estimate of what can be introduced or accepted in a specification, and (2) the setting up of correlations existing between these results, particularly between chemical analysis and mechanical test results. In addition to this statistical analysis concerning industrial results, several laboratory studies are presented, giving a more complete characterization of SA 508 class 3. All these results form a very complete documentation showing that SA 508 class 3 steel is suitable for the manufacture of large forged vessels requiring a high degree of reliability

288. Feocromocitoma Cardíaco a Nivel Del Surco Interauricular

Directory of Open Access Journals (Sweden)

C. Iglesias Gil

2012-04-01

La localización extraadrenal de los feocromocitomas es infrecuente, siendo la torácica inferior al 2% y la intrapericárdica excepcional. Dado que son escasos los reportes de tumores secretores de catecolaminas a nivel cardíaco, presentamos este caso.

Trasplante cardíaco: organización e indicaciones

Directory of Open Access Journals (Sweden)

José M. Revuelta

2008-01-01

La experiencia clínica está demostrando que las indicaciones y las contraindicaciones del trasplante cardíaco están en constante cambio, debido principalmente a los avances en los cuidados pre, per y postoperatorios, a los nuevos fármacos y otras novedosas alternativas terapéuticas. La clase funcional (NY HA del paciente es poco precisa para indicar el trasplante cardíaco, por lo que se precisa de otras determinaciones, como el consumo máximo de oxígeno: VO2 máx < 10 ml/kg/min conlleva un mortalidad hospitalaria elevada. Asimismo, la fracción de eyección ventricular izquierda disminuida (FEVI < 20% no debe considerarse como el indicador principal para establecer la indicación de trasplante, siendo necesario valorar otros factores de riesgo preoperatorios. En la última década, la experiencia ha puesto de manifiesto que algunas de las contraindicaciones absolutas, antes vigentes, no siempre deben desaconsejar el trasplante cardíaco.

12 CFR 508.13 - Decision of the Office.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Decision of the Office. 508.13 Section 508.13 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.13 Decision of the Office. (a) Within 30 days after the recommended decision has been certifie...

47 CFR 95.1509 - ASTM E2213-03 DSRC Standard.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false ASTM E2213-03 DSRC Standard. 95.1509 Section 95... ASTM E2213-03 DSRC Standard. On-Board Units operating in the 5850-5925 MHz band shall comply with the... Materials (ASTM) E2213-03, Standard Specification for Telecommunications and Information Exchange Between...

77 FR 10358 - Acceptance of ASTM F963-11 as a Mandatory Consumer Product Safety Standard

Science.gov (United States)

2012-02-22

... CONSUMER PRODUCT SAFETY COMMISSION 16 CFR Chapter II Acceptance of ASTM F963-11 as a Mandatory... have accepted the revised ASTM F963-11 standard titled, Standard Consumer Safety Specifications for Toy Safety. Pursuant to section 106 of the Consumer Product Safety Improvement Act of 2008, ASTM F963-11 will...

MODELO ACO PARA LA RECOLECCIÓN DE RESIDUOS POR CONTENEDORES ACO MODEL APPLIED TO THE WASTE COLLECTION BY CONTAINERS

Directory of Open Access Journals (Sweden)

Eduardo Salazar Hornig

2009-08-01

Full Text Available ACO es una metaheurística inspirada en el comportamiento de las colonias de hormigas para solucionar problemas de optimización combinatoria, por medio de la utilización de agentes computacionales simples que trabajan de manera cooperativa y se comunican mediante rastros de feromona artificiales. En este trabajo se presenta un modelo para resolver el Problema de Recolección de Residuos Domiciliarios por Contenedores, el que aplica un concepto de secuencias parciales de recolección que deben ser unidas para minimizar la distancia total de recolección. El problema de unir las secuencias parciales se representa como un TSP, el que es resuelto mediante un algoritmo ACO. En base a recomendaciones de la literatura, se calibran experimentalmente los parámetros del algoritmo y se recomiendan rangos de valores que representan buenos rendimientos promedio. El modelo se aplica a un sector de recolección de la comuna de San Pedro de la Paz, Chile, obteniéndose rutas de recolección que reducen la distancia total recorrida respecto de la actual ruta utilizada y de la solución obtenida con otro modelo desarrollado previamente.ACO is a metaheuristic inspired in the behavior of natural ant colonies to solve combinatorial optimization problems, based on simple agents that work cooperatively communicating by artificial pheromone trails. In this paper a model to solve the municipal waste collection problem by containers is presented, which applies a concept of partial collection sequences that must be joined to minimize the total collection distance. The problem to join the partial collection sequences is represented as a TSP, which is solved by an ACO algorithm. Based on the literature, algorithm parameters are experimentally calibrated and range of variations that represents good average solutions are recommended. The model is applied to a waste collection sector of the San Pedro de la Paz commune in Chile, obtaining recollection routes with less total

Hardware-efficient signal generation of layered/enhanced ACO-OFDM for short-haul fiber-optic links.

Science.gov (United States)

Wang, Qibing; Song, Binhuang; Corcoran, Bill; Boland, David; Zhu, Chen; Zhuang, Leimeng; Lowery, Arthur J

2017-06-12

Layered/enhanced ACO-OFDM is a promising candidate for intensity modulation and direct-detection based short-haul fiber-optic links due to its both power and spectral efficiency. In this paper, we firstly demonstrate a hardware-efficient real-time 9.375 Gb/s QPSK-encoded layered/enhanced asymmetrical clipped optical OFDM (L/E-ACO-OFDM) transmitter using a Virtex-6 FPGA. This L/E-ACO-OFDM signal is successfully transmitted over 20-km uncompensated standard single-mode fiber (S-SMF) using a directly modulated laser. Several methods are explored to reduce the FPGA's logic resource utilization by taking advantage of the L/E-ACO-OFDM's signal characteristics. We show that the logic resource occupation of L/E-ACO-OFDM transmitter is almost the same as that of DC-biased OFDM transmitter when they achieve the same spectral efficiency, proving its great potential to be used in a real-time short-haul optical transmission link.

Bending The Spending Curve By Altering Care Delivery Patterns: The Role Of Care Management Within A Pioneer ACO.

Science.gov (United States)

Hsu, John; Price, Mary; Vogeli, Christine; Brand, Richard; Chernew, Michael E; Chaguturu, Sreekanth K; Weil, Eric; Ferris, Timothy G

2017-05-01

Accountable care organizations (ACOs) appear to lower medical spending, but there is little information on how they do so. We examined the impact of patient participation in a Pioneer ACO and its care management program on rates of emergency department (ED) visits and hospitalizations and on Medicare spending. We used data for the period 2009-14, exploiting naturally staggered program entry to create concurrent controls to help isolate the program effects. The care management program (the ACO's primary intervention) targeted beneficiaries with elevated but modifiable risks for future spending. ACO participation had a modest effect on spending, in line with previous estimates. Participation in the care management program was associated with substantial reductions in rates for hospitalizations and both all and nonemergency ED visits, as well as Medicare spending, when compared to preparticipation levels and to rates and spending for a concurrent sample of beneficiaries who were eligible for but had not yet started the program. Rates of ED visits and hospitalizations were reduced by 6 percent and 8 percent, respectively, and Medicare spending was reduced by 6 percent. Targeting beneficiaries with modifiable high risks and shifting care away from the ED represent viable mechanisms for altering spending within ACOs. Project HOPE—The People-to-People Health Foundation, Inc.

27 CFR 19.508 - Consignor premises.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Consignor premises. 19.508 Section 19.508 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT...) Spirits or denatured spirits produced from petroleum, natural gas, or coal may not be transferred to...

A performance improvement and cost-efficient ACO-OFDM scheme for visible light communications

Science.gov (United States)

Zhang, Tiantian; Zhou, Ji; Zhang, Zhenshan; Qiao, Yaojun; Su, Fei; Yang, Aiying

2017-11-01

In this paper, we propose a performance improvement and cost-efficient discrete Hartley transform (DHT)-based asymmetrically clipped optical orthogonal frequency division multiplexing (ACO-OFDM) scheme for visible light communications (VLC). The simple one-dimensional modulation constellation and simplified encoding structure reduce the complexity of system considerably. The DHT-spreading technique is employed to reduce peak-to-average power ratio (PAPR) of ACO-OFDM signals. Moreover, the intra-symbol frequency-domain averaging (ISFA) technique is used to increase the accuracy of channel estimation by removing the effect of ambient noise in the VLC channel effectively. To verify the feasibility of the proposed scheme, we study its performance via simulation. This scheme reduces the requirement to the resolution of DAC and increases the tolerance to the nonlinear characteristics of LED, both of which are cost-efficient. At forward error correction (FEC) limit (BER = 1 × 10-3), simulation results illustrate that compared with DHT-based ACO-OFDM without the ISFA technique, our scheme has 3.2 dB and 2.7 dB improvement of the required Eb /N0 when BPSK and 4-PAM are modulated, respectively.

RNA Interference of 1-Aminocyclopropane-1-carboxylic Acid Oxidase (ACO1 and ACO2 Genes Expression Prolongs the Shelf Life of Eksotika (Carica papaya L. Papaya Fruit

Directory of Open Access Journals (Sweden)

Rogayah Sekeli

2014-06-01

Full Text Available The purpose of this study was to evaluate the effectiveness of using RNA interference in down regulating the expression of 1-aminocyclopropane-1-carboxylic acid oxidase gene in Eksotika papaya. One-month old embryogenic calli were separately transformed with Agrobacterium strain LBA 4404 harbouring the three different RNAi pOpOff2 constructs bearing the 1-aminocyclopropane-1-carboxylic acid oxidase gene. A total of 176 putative transformed lines were produced from 15,000 calli transformed, selected, then regenerated on medium supplemented with kanamycin. Integration and expression of the targeted gene in putatively transformed lines were verified by PCR and real-time RT-PCR. Confined field evaluation of a total of 31 putative transgenic lines planted showed a knockdown expression of the targeted ACO1 and ACO2 genes in 13 lines, which required more than 8 days to achieve the full yellow colour (Index 6. Fruits harvested from lines pRNAiACO2 L2-9 and pRNAiACO1 L2 exhibited about 20 and 14 days extended post-harvest shelf life to reach Index 6, respectively. The total soluble solids contents of the fruits ranged from 11 to 14° Brix, a range similar to fruits from non-transformed, wild type seed-derived plants.

Hospitals Participating In ACOs Tend To Be Large And Urban, Allowing Access To Capital And Data.

Science.gov (United States)

Colla, Carrie H; Lewis, Valerie A; Tierney, Emily; Muhlestein, David B

2016-03-01

Relationships between physicians and hospitals have changed considerably over the past decade, as hospitals and physician groups have integrated and new public and private payment policies have created financial interdependence. The extent to which accountable care organizations (ACOs) involve hospitals in their operations may prove to be vitally important, because managing hospital care is a key part of improving health care quality and lowering cost growth. Using primary data on ACO composition and capabilities paired with hospital characteristics, we found that 20 percent of US hospitals were part of an ACO in 2014. Hospitals that were in urban areas, were nonprofit, or had a smaller share of Medicare patients were more likely to participate in ACOs, compared to hospitals that were in more rural areas, were for-profit or government owned, or had a larger share of Medicare patients, respectively. Qualitative data identified the following advantages of including a hospital in an ACO: the availability of start-up capital, advanced data sharing, and engagement of providers across the care continuum. Although the 63 percent of ACOs that included hospitals offered more comprehensive services compared to ACOs without hospitals, we found no differences between the two groups in their ability to manage hospital-related aspects of patient care. Project HOPE—The People-to-People Health Foundation, Inc.

76 FR 78614 - Welded ASTM A-312 Stainless Steel Pipe From South Korea and Taiwan: Continuation of Antidumping...

Science.gov (United States)

2011-12-19

... DEPARTMENT OF COMMERCE International Trade Administration [A-580-810, A-583-815] Welded ASTM A-312... revocation of the antidumping duty orders on welded ASTM A-312 stainless steel pipe from South Korea (Korea... December 30, 1992, the Department published the antidumping duty orders on welded ASTM A-312 stainless...

Ductile fracture toughness of heavy section pressure vessel steel plate. A specimen-size study of ASTM A 533 steels

International Nuclear Information System (INIS)

Williams, J.A.

1979-09-01

The ductile fracture toughness, J/sub Ic/, of ASTM A 533, Grade B, Class 1 and ASTM A 533, heat treated to simulate irradiation, was determined for 10- to 100-mm thick compact specimens. The toughness at maximum specimen load was also measured to determine the conservatism of J/sub Ic/. The toughness of ASTM A 533, Grade B, Class 1 steel was 349 kJ/m 2 and at the equivalent upper shelf temperature, the heat treated material exhibited 87 kJ/m 2 . The maximum load fracture toughness was found to be linearly proportional to specimen size, and only specimens which failed to meet ASTM size criteria exhibited maximum load toughness less than J/sub Ic/

Do accountable care organizations (ACOs) help or hinder primary care physicians' ability to deliver high-quality care?

Science.gov (United States)

Berenson, Robert A; Burton, Rachel A; McGrath, Megan

2016-09-01

Many view advanced primary care models such as the patient-centered medical home as foundational for accountable care organizations (ACOs), but it remains unclear how these two delivery reforms are complementary and how they may produce conflict. The objective of this study was to identify how joining an ACO could help or hinder a primary care practice's efforts to deliver high-quality care. This qualitative study involved interviews with a purposive sample of 32 early adopters of advanced primary care and/or ACO models, drawn from across the U.S. and conducted in mid-2014. Interview notes were coded using qualitative data analysis software, permitting topic-specific queries which were then summarized. Respondents perceived many potential benefits of joining an ACO, including care coordination staff, data analytics, and improved communication with other providers. However, respondents were also concerned about added "bureaucratic" requirements, referral restrictions, and a potential inability to recoup investments in practice improvements. Interviewees generally thought joining an ACO could complement a practice's efforts to deliver high-quality care, yet noted some concerns that could undermine these synergies. Both the advantages and disadvantages of joining an ACO seemed exacerbated for small practices, since they are most likely to benefit from additional resources yet are most likely to chafe under added bureaucratic requirements. Our identification of the potential pros and cons of joining an ACO may help providers identify areas to examine when weighing whether to enter into such an arrangement, and may help ACOs identify potential areas for improvement. Copyright © 2016 Elsevier Inc. All rights reserved.

29 CFR 779.508 - Eighteen-year minimum.

Science.gov (United States)

2010-07-01

... RETAILERS OF GOODS OR SERVICES Other Provisions Which May Affect Retail Enterprises Child Labor Provisions... 29 Labor 3 2010-07-01 2010-07-01 false Eighteen-year minimum. 779.508 Section 779.508 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL...

ASTM Standards for Reactor Dosimetry and Pressure Vessel Surveillance

International Nuclear Information System (INIS)

GRIFFIN, PATRICK J.

1999-01-01

The ASTM standards provide guidance and instruction on how to field and interpret reactor dosimetry. They provide a roadmap towards understanding the current ''state-of-the-art'' in reactor dosimetry, as reflected by the technical community. The consensus basis to the ASTM standards assures the user of an unbiased presentation of technical procedures and interpretations of the measurements. Some insight into the types of standards and the way in which they are organized can assist one in using them in an expeditious manner. Two example are presented to help orient new users to the breadth and interrelationship between the ASTM nuclear metrology standards. One example involves the testing of a new ''widget'' to verify the radiation hardness. The second example involves quantifying the radiation damage at a pressure vessel critical weld location through surveillance dosimetry and calculation

Impact of heat treatment on HSS cutting tool (ASTM A600) and its behaviour during machining of mild steel (ASTM A36)

Science.gov (United States)

Afolalu, S. A.; Abioye, O. P.; Salawu, E. Y.; Okokpujie, I. P.; Abioye, A. A.; Omotosho, O. A.; Ajayi., O. O.

2018-04-01

Carburization is one the best heat treatment that responded well to hardening with Palm Kernel Shell giving the best hardness value. This work studied the influence of carburization on HSStool(ASTM A600) and its behaviour during machining of mild steel (ASTM A36). Composition of the samples (12 pieces of 180 × 12 × 12 mm) HSS tools were checked using UV-VIS spectrometer and the tools were carburized with PKS at holding temperatures and time of 800, 850, 900, 950 °C and 60,90 120 minutes using muffle furnance. The micro structural analysis, surface and core hardnessof the treated samples gave better results than the untreated samples when checked withsoft driven and optical microscope. It wasalso observed that increase in the feed rate and depth for length of cut of 50 mm significantly reduces the wear progression and thereby gave best machining time at maximum carburizing temperature and time(950 °C / 120 minutes) when it was used to cut mild steelon the lathe machine.

76 FR 67673 - Welded ASTM A-312 Stainless Steel Pipe From South Korea and Taiwan: Final Results of Expedited...

Science.gov (United States)

2011-11-02

... DEPARTMENT OF COMMERCE International Trade Administration [A-580-810, A-583-815] Welded ASTM A-312... the antidumping duty orders on welded ASTM A-312 stainless steel pipe from South Korea and Taiwan... duty orders on welded ASTM A-312 stainless steel pipe from South Korea and Taiwan pursuant to section...

76 FR 12370 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

Science.gov (United States)

2011-03-07

... Production Act of 1993--ASTM International Standards Notice is hereby given that, on February 4, 2011... seq. (``the Act''), ASTM International Standards (``ASTM'') has filed written notifications.... Specifically, ASTM has provided an updated list of current, ongoing ASTM standards activities originating...

Housing, Transportation, And Food: How ACOs Seek To Improve Population Health By Addressing Nonmedical Needs Of Patients.

Science.gov (United States)

Fraze, Taressa; Lewis, Valerie A; Rodriguez, Hector P; Fisher, Elliott S

2016-11-01

Addressing nonmedical needs-such as the need for housing-is critical to advancing population health, improving the quality of care, and lowering the costs of care. Accountable care organizations (ACOs) are well positioned to address these needs. We used qualitative interviews with ACO leaders and site visits to examine how these organizations addressed the nonmedical needs of their patients, and the extent to which they did so. We developed a typology of medical and social services integration among ACOs that disentangles service and organizational integration. We found that the nonmedical needs most commonly addressed by ACOs were the need for transportation and housing and food insecurity. ACOs identified nonmedical needs through processes that were part of the primary care visit or care transformation programs. Approaches to meeting patients' nonmedical needs were either individualized solutions (developed patient by patient) or targeted approaches (programs developed to address specific needs). As policy makers continue to provide incentives for health care organizations to meet a broader spectrum of patients' needs, these findings offer insights into how health care organizations such as ACOs integrate themselves with nonmedical organizations. Project HOPE—The People-to-People Health Foundation, Inc.

78 FR 1884 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

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2013-01-09

... Production Act of 1993--ASTM International Standards Notice is hereby given that, on December 12, 2012... seq. (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between...

78 FR 35646 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

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2013-06-13

... Production Act of 1993--ASTM International Standards Notice is hereby given that, on May 10, 2013, pursuant... seq. (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between...

77 FR 34069 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

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2012-06-08

... Production Act of 1993--ASTM International Standards Notice is hereby given that, on May 11, 2012, pursuant... seq. (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between...

77 FR 61786 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

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2012-10-11

... Production Act of 1993--ASTM International Standards Notice is hereby given that, on September 10, 2012... seq. (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between May...

78 FR 64248 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

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2013-10-28

... Production Act of 1993--ASTM International Standards Notice is hereby given that, on September 16, 2013... seq. (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between May...

76 FR 34252 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; ASTM...

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2011-06-13

... Production Act of 1993; ASTM International Standards Notice is hereby given that, on May 11, 2011, pursuant... seq. (``the Act''), ASTM International Standards (``ASTM'') has filed written notifications.... Specifically, ASTM has provided an updated list of current, ongoing ASTM standards activities originating...

78 FR 14836 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

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2013-03-07

... Production Act of 1993--ASTM International Standards Notice is hereby given that, on February 11, 2013... seq. (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between...

[ACOS: Clinical and functional features The Russian formulation mesalazine (kansalazine) in the therapy of ulcerative colitis].

Science.gov (United States)

Sobko, E A; Chubarova, S V; Demko, I V; Loktionova, M M; Ishchenko, O P; Solovyeva, I A; Kraposhina, A Yu; Gordeeva, N V

To investigate the clinical and functional parameters in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) versus those with chronic obstructive pulmonary disease (COPD) and asthma. A total of 129 people were examined. 51 patients with ACOS were followed up in Group 1; Group 2 included 38 patients with severe asthma; Group 3 consisted of 40 patients with severe COPD. All the patients underwent clinical examination: history data collection, physical examination, evaluation of disease symptoms, and study of respiratory function (spirometry, body plethysmography). ACOS is clinically characterized by considerable demands for emergency drugs and by more frequent asthmatic fits and exacerbations, which require hospitalization. The parameters of bronchial resistance in ACOS were established to be increased throughout the follow-up period and to be comparable with those in patients with COPD. In the patients with ACOS, the severity of pulmonary hyperinflation was associated with increased demands for emergency drugs (r=0.59; p=0.015). Fixed bronchial obstruction in ACOS can be caused by smoking intensity and duration associated with increased bronchial resistance in expiration (r=0.51; p=0.003) and intrathoracic volume (r=0.71; p=0.0001); as well as increased body mass index (p<0.001) and disease duration, which were interrelated with a reduction in the forced expiratory volume in one second/forced vital capacity ratio (r=-0.63; p=0.001 and r=-0.71; p=0.0034, respectively). Patients with ACOS show more severe clinical manifestations and a substantial increase in functional residual capacity and intrathoracic volume throughout the follow-up period, suggesting that the distal bronchi are impaired and pulmonary hyperinflation develops.

Annual Book of ASTM Standards, Part 23: Water; Atmospheric Analysis.

Science.gov (United States)

American Society for Testing and Materials, Philadelphia, PA.

Standards for water and atmospheric analysis are compiled in this segment, Part 23, of the American Society for Testing and Materials (ASTM) annual book of standards. It contains all current formally approved ASTM standard and tentative test methods, definitions, recommended practices, proposed methods, classifications, and specifications. One…

Isothermal Bainite Processing of ASTM A723 Components

Science.gov (United States)

1993-09-01

4 List of Illustrations 1. Photograph of typical cylinders used in the present study ................................. 7 2. CCT diagram for... CCT ) diagram obtained by thermal and magnetic analyses for the high nickel (-3 percent) ASTM A723 steel. The bainite knee for the 2 percent nickel...block. Also shown is the slope giving the average cooling rate in the critical region of the CCT diagram . This average rate happens to approximately

Combating Wear of ASTM A36 Steel by Surface Modification Using Thermally Sprayed Cermet Coatings

Directory of Open Access Journals (Sweden)

Vineet Shibe

2016-01-01

Full Text Available Thermal spray coatings can be applied economically on machine parts to enhance their requisite surface properties like wear, corrosion, erosion resistance, and so forth. Detonation gun (D-Gun thermal spray coatings can be applied on the surface of carbon steels to improve their wear resistance. In the present study, alloy powder cermet coatings WC-12% Co and Cr3C2-25% NiCr have been deposited on ASTM A36 steel with D-Gun thermal spray technique. Sliding wear behavior of uncoated ASTM A36 steel and D-Gun sprayed WC-12% Co and Cr3C2-25% NiCr coatings on base material is observed on a Pin-On-Disc Wear Tester. Sliding wear performance of WC-12% Co coating is found to be better than the Cr3C2-25% NiCr coating. Wear performance of both these cermet coatings is found to be better than uncoated ASTM A36 steel. Thermally sprayed WC-12% Co and Cr3C2-25% NiCr cermet coatings using D-Gun thermal spray technique is found to be very useful in improving the sliding wear resistance of ASTM A36 steel.

Spectrophotometric determination of the ASTM color of diesel oil

Energy Technology Data Exchange (ETDEWEB)

Douglas Willian Emanuel Alves Santana; Marcelle Prates Sepulveda; Paulo Jorge Sanches Barbeira

2007-03-15

One of the parameters analyzed to determine the quality of diesel oil is its ASTM color. Changes in color may be indicative of problems in the production process, contamination, degradation or the oxidation of diesel. The methodology recommended for determining the color of automotive diesel oil samples is the colorimetry according to standard ASTM D1500, in which a sample is introduced into a glass cell and the color of the sample is compared with an optical filter color scale. Although it is very simple, the manual method requires good visual acuity from the operator. This procedure becomes somewhat subjective in some cases since different operators can make distinct evaluations of the same sample. In this way, this work proposes the development of a spectrophotometric analysis methodology to eliminate the subjectiveness in the determination of ASTM color of diesel oil samples by using operator-independent parameters and making quality assay more accurate and precise. Short communication. 7 refs., 2 figs., 2 tabs.

77 FR 1085 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

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2012-01-09

... Production Act of 1993--ASTM International Notice is hereby given that, on December 5, 2011, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between...

75 FR 11196 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

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2010-03-10

... Production Act of 1993--ASTM International Notice is hereby given that, on February 16, 2010, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between May...

75 FR 65657 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

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2010-10-26

... Production Act of 1993--ASTM International Notice is hereby given that, on September 23, 2010, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between May...

76 FR 63658 - Notice Pursuant to the National Cooperative Research and Production Act of 1993; ASTM International

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2011-10-13

... Production Act of 1993; ASTM International Notice is hereby given that, on August 31, 2011, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the..., ASTM has provided an updated list of current, ongoing ASTM standards activities originating between May...

77 FR 14046 - Amended Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM...

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2012-03-08

... Research and Production Act of 1993--ASTM International Standards Notice is hereby given that, on February..., 15 U.S.C. 4301 et seq. (``the Act''), ASTM International Standards (``ASTM'') has filed written... circumstances. Specifically, ASTM has provided an updated list of current, ongoing ASTM standards activities...

ACO-Initialized Wavelet Neural Network for Vibration Fault Diagnosis of Hydroturbine Generating Unit

OpenAIRE

Xiao, Zhihuai; He, Xinying; Fu, Xiangqian; Malik, O. P.

2015-01-01

Considering the drawbacks of traditional wavelet neural network, such as low convergence speed and high sensitivity to initial parameters, an ant colony optimization- (ACO-) initialized wavelet neural network is proposed in this paper for vibration fault diagnosis of a hydroturbine generating unit. In this method, parameters of the wavelet neural network are initialized by the ACO algorithm, and then the wavelet neural network is trained by the gradient descent algorithm. Amplitudes of the fr...

Chronic ankle pain and fibrosis successfully treated with a new noninvasive augmented soft tissue mobilization technique (ASTM): a case report.

Science.gov (United States)

Melham, T J; Sevier, T L; Malnofski, M J; Wilson, J K; Helfst, R H

1998-06-01

This clinical case report demonstrates the clinical effectiveness of a new form of soft tissue mobilization in the treatment of excessive connective tissue fibrosis (scar tissue) around an athlete's injured ankle. The scar tissue was causing the athlete to have pain with activity, pain on palpation of the ankle, decreased range of motion, and loss of function. Surgery and several months of conventional physical therapy failed to alleviate the athlete's symptoms. As a final resort, augmented soft tissue mobilization (ASTM) was administered. ASTM is an alternative nonsurgical treatment modality that is being researched at Performance Dynamics (Muncip, IN). ASTM is a process that uses ergonomically designed instruments that assist therapists in the rapid localization and effective treatment of areas exhibiting excessive soft tissue fibrosis. This is followed by a stretching and strengthening program. Upon the completion of 6 wk of ASTM therapy, the athlete had no pain and had regained full range of motion and function. This case report is an example of how a noninvasive augmented form of soft tissue mobilization (ASTM) demonstrated impressive clinical results in treating a condition caused by connective tissue fibrosis.

Interdisciplinariedade: entre o desejo e a prática dos profissionais do transplante cardíaco no Instituto Dante Pazzanese de Cardiologia

OpenAIRE

Santos, Nadja Maria Codá dos

2005-01-01

Esta dissertação tem o objetivo geral de: analisar a prática interdisciplinar nos 13 anos de transplante cardíaco no Instituto Dante Pazzanese de Cardiologia IDPC. Buscou como objetivos específicos: resgatar a história do transplante cardíaco no IDPC; analisar as perspectivas dos profissionais sobre a contribuição de sua profissão e das demais para o trabalho interdisciplinar; estudar contribuição do Serviço Social para a prática interdisciplinar. Na prática do transplante cardíaco, inserid...

F508del-CFTR rescue: a matter of cell stress response.

Science.gov (United States)

Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro

2013-01-01

Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature.

Cor ASTM: um método simples e rápido para determinar a qualidade do biodiesel produzido a partir de óleos residuais de fritura ASTM color: a simple and fast method for determining quality of biodiesel produced from used cooking oils

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Verônica Santos de Morais

2013-01-01

Full Text Available In this study, 23 biodiesel samples were produced, 20 from used cooking oil and the remaining 3 from refined soybean oil. The following properties were determined in all of the samples (oil and its respective biodiesel: density; viscosity; total acid number and ASTM color. The results indicated high correlation (R > 0.6 between ASTM color of used cooking oil and total acid number of its resultant biodiesel. This high correlation allows prediction of the quality of the biodiesel produced using a simple and fast procedure such as ASTM color.

7 CFR 1901.508 - Servicing of insured notes outstanding with investors.

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Servicing of insured notes outstanding with investors. 1901.508 Section 1901.508 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... Ownership and Insured Notes § 1901.508 Servicing of insured notes outstanding with investors. The Director...

Impact of Provider Participation in ACO Programs on Preventive Care Services, Patient Experiences, and Health Care Expenditures in US Adults Aged 18-64.

Science.gov (United States)

Hong, Young-Rock; Sonawane, Kalyani; Larson, Samantha; Mainous, Arch G; Marlow, Nicole M

2018-05-15

Little is known about the impact of accountable care organization (ACO) on US adults aged 18-64. To examine whether having a usual source of care (USC) provider participating in an ACO affects receipt of preventive care services, patient experiences, and health care expenditures among nonelderly Americans. A cross-sectional analysis of the 2015 Medical Organizations Survey linked with the Medical Expenditure Panel Survey. Survey respondents aged 18-64 with an identified USC and continuous health insurance coverage during 2015. Preventative care services (routine checkup, flu vaccination, and cancer screening), patient experiences with health care (access to care, interaction quality with providers, and global satisfaction), and health care expenditures (total and out-of-pocket expenditures) for respondents with USC by ACO and non-ACO provider groups. Among 1563, nonelderly Americans having a USC, we found that nearly 62.7% [95% confidence interval (CI), 58.6%-66.7%; representing 15,722,208 Americans] were cared for by ACO providers. Our analysis showed no significant differences in preventive care services or patient experiences between ACO and non-ACO groups. Adjusted mean total health expenditures were slightly higher for the ACO than non-ACO group [$7016 (95% CI, $4949-$9914) vs. $6796 (95% CI, $4724-$9892)]; however, this difference was not statistically significant (P=0.250). Our findings suggest that having a USC provider participating in an ACO is not associated with preventive care services use, patient experiences, or health care expenditures among a nonelderly population.

Caso clínico del Departamento de Psiquiatría: Trastorno afectivo bipolar 1, episodio maníaco

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José Manuel Calvo Gómez

1995-04-01

Full Text Available Se trata de un paciente de 21 años con un cuadro clínico de una semana de evolución cuyas características satisfacen los criterios diagnósticos de la Cuarta Edición del Manual Estadístico y Diagnóstico de los Trastornos Mentales (DSM IV para trastorno afectivo bipolar 1,episodio maníaco severo con características psicóticas congruentes con el estado de ánimo. Criterios diagnósticos para trastorno afectivo bipolar 1: A. Actualmente (o recientemente en episodio maníaco. B. Ha existido previamente al menos un episodio depresivo mayor, episodio maníaco o episodio mixto. C. Los episodios afectivos de los criterios A y B no son producidos por un trastorno esquizoafectivo y no están superpuestos sobre esquizofrenia, trastorno esquizofreniforme, trastorno delirante, o trastorno psicótico no especificado en otro sitio.

Developing the (ASTM) voluntary consensus standards required to help implement the National Energy Plan

International Nuclear Information System (INIS)

Anon.

1981-01-01

The recommended guide is the first American Society for Testing and Materials (ASTM) matrix in a family of such documents that combined, will help manage the development of the ASTM standards considered necessary to implement the current National Plan for Energy Research, Development, and Demonstration. It is expected that the guide will provide a framework for standards development to complement the nation's research and development in support of critical energy needs. The recommended guide identifies the energy-critical areas that are to be developed, the master ASTM recommended guide for developing the standards required to help the National Plan, the section in which each energy-critical area is covered, and the suggested ASTM lead committee responsible for each area (fossil, solar, geothermal, conservation, fusion, and fission reactor development). A comprehensive matrix to identify the areas of need for which ASTM standards will be required to help implement the National Energy Plan is also presented

Characterization of ASTM round-robin tungsten-powder samples

International Nuclear Information System (INIS)

Slettevold, C.A.; Biermann, A.H.

1975-01-01

The Lawrence Livermore Laboratory Particle Characterization Laboratory Group has participated in an industry-wide round-robin investigation on characterization of tungsten powder. sponsored by the ASTM Subcommittee on Refractory-Metal Powders (B-09.3). The analyses performed at the suggestion of the ASTM subcommittee included measurements of tap density, apparent density, true density, average particle size, and surface area. Determinations of particle-weight and size distributions were also performed and particle inspection conducted by microscopy. This report describes the equipment and procedures used and summarizes the results of these analyses. (9 tables, 17 fig) (U.S.)

ASTM standards associated with PWR and BWR power plant licensing, operation and surveillance

International Nuclear Information System (INIS)

McElroy, W.N.; McElroy, R.J.; Gold, R.; Lippincott, E.P.; Lowe, A.L. Jr.

1994-01-01

This paper considers ASTM Standards that are available, under revision, and are being considered in support of Pressurized Water Reactor (PWR) and Boiling Water Reactor (BWR) Nuclear Power Plant (NPP) licensing, regulation, operation, surveillance and life attainment. The current activities of ASTM Committee E10 and its Subcommittees E10.02 and current activities of ASTM Committee E10 and its Subcommittees E10.02 and E10.05 and their Task Groups (TG) are described. A very important aspect of these efforts is the preparation, revision, and balloting of standards identified in the ASTM E706 Standard on Master Matrix for Light Water Reactor (LWR) Pressure Vessel (PV) Surveillance Standards. The current version (E706-87) of the Master Matrix identifies 21 ASTM LWR physics-dosimetry-metallurgy standards for Reactor Pressure Vessel (RPV) and Support Structure (SS) surveillance programs, whereas, for the next revision 34 standards are identified. The need for national and international coordination of Standards Technology Development, Transfer and Training (STDTT) is considered in this and other Symposium papers that address specific standards related physics-dosimetry-metallurgy issues. 69 refs

ACO-Initialized Wavelet Neural Network for Vibration Fault Diagnosis of Hydroturbine Generating Unit

Directory of Open Access Journals (Sweden)

Zhihuai Xiao

2015-01-01

Full Text Available Considering the drawbacks of traditional wavelet neural network, such as low convergence speed and high sensitivity to initial parameters, an ant colony optimization- (ACO- initialized wavelet neural network is proposed in this paper for vibration fault diagnosis of a hydroturbine generating unit. In this method, parameters of the wavelet neural network are initialized by the ACO algorithm, and then the wavelet neural network is trained by the gradient descent algorithm. Amplitudes of the frequency components of the hydroturbine generating unit vibration signals are used as feature vectors for wavelet neural network training to realize mapping relationship from vibration features to fault types. A real vibration fault diagnosis case result of a hydroturbine generating unit shows that the proposed method has faster convergence speed and stronger generalization ability than the traditional wavelet neural network and ACO wavelet neural network. Thus it can provide an effective solution for online vibration fault diagnosis of a hydroturbine generating unit.

The USCG/environment Canada/ASTM standards development program

International Nuclear Information System (INIS)

Whittaker, H.

1992-01-01

Environment Canada's Emergencies Engineering Division (EED) has been charged, as a result of the Public Review Panel on Tanker Safety and Marine Emergency Response report, with increased R ampersand D in marine oil spills. This activity will, of necessity, include development of standards and guidelines for the testing and/or usage of oil spill cleanup equipment. The United States Coast Guard (USCG) has been charged with implementing the provisions of the Oil Pollution Act of 1990 (OPA-90), as it pertains to marine transportation vessels and facilities. Among the provisions are requirements for vessel and facility owners and operators to develop comprehensive response plans that specifically match response resources to spill removal requirements. Meeting the response plan provisions of OPA-90 requires common standards for testing, selecting and assigning resources to anticipated response needs and objectively evaluating response plans for adequacy. In August of 1991, the USCG OPA-90 office approached ASTM to determine the feasibility of developing standards through that organizations procedures. Meetings were then held between the OPA-90 staff and members of the ASTM Committee F-20 on Hazardous Substances and Oil Spill Response. An agreement was reached to commence standards development in the areas of: Barriers, Skimmers, Treating Agents, Pumps, Beach Clean-up, Sorbents, Bioremediation, In-situ Burning, Temporary Storage Devices, Communications, Remote Sensing. It was recognized that ASTM and other organizational standards existed in several of these areas, but there were those where none were known to exist. Standards development was, therefore, expected to be a complicated and time-consuming process. Both the USCG OPA-90 and EC/EED offices required standards to be developed quickly, without subverting the ASTM process. Mechanical containment and recovery was considered to be the primary area of concern for both groups

31 CFR 594.508 - Transactions related to telecommunications authorized.

Science.gov (United States)

2010-07-01

... telecommunications authorized. 594.508 Section 594.508 Money and Finance: Treasury Regulations Relating to Money and... related to telecommunications authorized. All transactions ordinarily incident to the receipt or transmission of telecommunications involving persons whose property or interests in property are blocked...

31 CFR 545.508 - Transactions related to telecommunications authorized.

Science.gov (United States)

2010-07-01

... telecommunications authorized. 545.508 Section 545.508 Money and Finance: Treasury Regulations Relating to Money and... related to telecommunications authorized. All transactions ordinarily incident to the receipt or transmission of telecommunications involving the territory of Afghanistan controlled by the Taliban are...

Construction of the Orsay ACO storage ring, 1: progress report. 2: detecting systems; La construction de l'anneau de stockage ACO d'Orsay, 1: etat des travaux. 2: systemes de detection

Energy Technology Data Exchange (ETDEWEB)

Blanc-Lapierre, A; Arzelier, G; Beck, R A; Belbeoch, R; Boutouyrie, B; Bruck, H; Burnod, L; Gendreau, G; Gratreau, P; Haissinski, J; Jolivot, R; Laborde, J; Le Duff, J; Leleux, G; Marin, P C; Milman, B; Sommer, E; Zyngier, H [Laboratoire de l' Accelerateur Lineaire, 91 - Orsay (France); [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Augustin, J E; Rumpf, F; Silva, E

1966-07-01

1. - A brief progress report is given, with mention of the difficulties solved since the 1963 Dubna Conference and the extra facilities which will be available on the ring (beam observation and measurements); 2. - Typical large solid angle detecting systems and equipment for accurate monitoring under construction at Orsay are also presented. Emphasis is put on some peculiar features at ACO as a tool for physics: long experimental straight section and short length of the bunches. (authors) [French] 1. - Un bref rapport est presente sur l'etat d'avancement du projet ACO en precisant les difficultes resolues depuis la Conference de Dubna en 1963, et les moyens nouveaux mis en place sur l'anneau pour les observations et mesures sur les faisceaux; 2. - Des systemes de detection a grand angle solide et de monitorage precis, en construction a Orsay, sont egalement presentes. On insiste sur quelques traits particuliers d'ACO en tant qu'outil de travail de physique: section droite experimentale longue et paquets courts. (auteurs)

Standard guide for high-resolution gamma-ray spectrometry of soil samples. ASTM standard

International Nuclear Information System (INIS)

1998-12-01

This guide is under the jurisdiction of ASTM Committee C-26 on Nuclear Fuel Cycle and is the direct responsibility of Subcommittee C26.05 on Methods of Test. The current edition was approved on Jul. 10, 1998. It was published in December 1998. Copyright American Society for Testing and Materials (ASTM), 100 Barr Harbor Drive, West Conshohocken, PA, 19428, USA. This document is available from NTIS under license from ASTM

ASTM standards for fire debris analysis: a review.

Science.gov (United States)

Stauffer, Eric; Lentini, John J

2003-03-12

The American Society for Testing and Materials (ASTM) recently updated its standards E 1387 and E 1618 for the analysis of fire debris. The changes in the classification of ignitable liquids are presented in this review. Furthermore, a new standard on extraction of fire debris with solid phase microextraction (SPME) was released. Advantages and drawbacks of this technique are presented and discussed. Also, the standard on cleanup by acid stripping has not been reapproved. Fire debris analysts that use the standards should be aware of these changes.

Integrating Medication Therapy Management (MTM Services Provided by Community Pharmacists into a Community-Based Accountable Care Organization (ACO

Directory of Open Access Journals (Sweden)

Brian Isetts

2017-10-01

Full Text Available (1 Background: As the U.S. healthcare system evolves from fee-for-service financing to global population-based payments designed to be accountable for both quality and total cost of care, the effective and safe use of medications is gaining increased importance. The purpose of this project was to determine the feasibility of integrating medication therapy management (MTM services provided by community pharmacists into the clinical care teams and the health information technology (HIT infrastructure for Minnesota Medicaid recipients of a 12-county community-based accountable care organization (ACO. (2 Methods: The continuous quality improvement evaluation methodology employed in this project was the context + mechanism = outcome (CMO model to account for the fact that programs only work insofar as they introduce promising ideas, solutions and opportunities in the appropriate social and cultural contexts. Collaborations between a 12-county ACO and 15 community pharmacies in Southwest Minnesota served as the social context for this feasibility study of MTM referrals to community pharmacists. (3 Results: All 15 community pharmacy sites were integrated into the HIT infrastructure through Direct Secure Messaging, and there were 32 recipients who received MTM services subsequent to referrals from the ACO at 5 of the 15 community pharmacies over a 1-year implementation phase. (4 Conclusion: At the conclusion of this project, an effective electronic communication and MTM referral system was activated, and consideration was given to community pharmacists providing MTM in future ACO shared savings agreements.

ALOHA Cabled Observatory (ACO): Acoustic Doppler Current Profiler (ADCP): Velocity

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The University of Hawaii's ALOHA ("A Long-term Oligotrophic Habitat Assessment") Cabled Observatory (ACO) is located 100 km north of the island of Oahu, Hawaii (22...

41 CFR 101-26.508-3 - Consolidation of requisitions.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Consolidation of requisitions. 101-26.508-3 Section 101-26.508-3 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT...

75 FR 30440 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

Science.gov (United States)

2010-06-01

... Production Act of 1993--ASTM International Notice is hereby given that, on May 6, 2010, pursuant to Section 6... Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the Attorney... recovery of antitrust plaintiffs to actual damages under specified circumstances. Specifically, ASTM has...

Prevalence of nursing diagnosis of decreased cardiac output and the predictive value of defining characteristics in patients under evaluation for heart transplant Prevalencia del diagnóstico de enfermería de disminución del gasto cardíaco y valor predictivo de las características definidoras en pacientes en fase de evaluación para trasplante cardíaco Prevalência do diagnóstico de enfermagem de débito cardíaco diminuído e valor preditivo das características definidoras em pacientes em avaliação para transplante cardíaco

Directory of Open Access Journals (Sweden)

Lígia Neres Matos

2012-04-01

Full Text Available The purposes of the study were to identify the prevalence of defining characteristics (DC of decreased cardiac output (DCO in patients with cardiac insufficiency under evaluation for heart transplantation, and to ascertain the likelihood of defining characteristics being predictive factors for the existence of reduction in cardiac output. Data was obtained by retrospective documental analysis of the clinical records of right-sided heart catheterizations in 38 patients between 2004 and 2009. The results showed that 71.1% of the patients had decreased cardiac output (measured by cardiac index. The majority of the NANDA-International defining characteristics for DCO were more frequent in individuals with reduced cardiac index levels. The study emphasizes the odds ratio (OR for increased Systemic Vascular Resistance of OR=4.533, of the third heart sound with OR=3.429 and the reduced ejection fraction with OR=2.850. By obtaining the predictive values for the defining characteristics the study identifies them as diagnostic indicators of decreased cardiac output.El estudio tiene como objetivos identificar la prevalencia de las características definitorias de la disminución del gasto cardíaco (DGC en pacientes con insuficiencia cardíaca (IC en evaluación para el trasplante de corazón y ver la probabilidad de las características definitorias sean factores predictivos de la existencia de una disminución del gasto cardíaco. Los datos se obtuvieron mediante el análisis documental retrospectivo de historias clínicas de cateterismo cordiaco derecho en 38 pacientes con insuficiencia cardíaca en la evaluación para el trasplante de corazón entre 2004 y 2009. Los resultados mostraron que el 71% de los pacientes habían reducido el gasto cardíaco (medido por el índice cardíaco. La mayoría de las características definitorias de la NANDA-International para el DGC fueron más frecuentes en individuos con índice cardíaco reducido. Los aspectos m

48 CFR 9.508 - Examples.

Science.gov (United States)

2010-10-01

... CONTRACTOR QUALIFICATIONS Organizational and Consultant Conflicts of Interest 9.508 Examples. The examples in paragraphs (a) through (i) following illustrate situations in which questions concerning organizational... (e.g., fire control, navigation, etc.). In this example, the system is the powerplant, not the...

Method for Estimating Evaporative Potential (IM/CLO) from ASTM Standard Single Wind Velocity Measures

Science.gov (United States)

2016-08-10

IM/CLO) FROM ASTM STANDARD SINGLE WIND VELOCITY MEASURES DISCLAIMER The opinions or assertions contained herein are the private views of the...USARIEM TECHNICAL REPORT T16-14 METHOD FOR ESTIMATING EVAPORATIVE POTENTIAL (IM/CLO) FROM ASTM STANDARD SINGLE WIND VELOCITY... ASTM STANDARD SINGLE WIND VELOCITY MEASURES Adam W. Potter Biophysics and Biomedical Modeling Division U.S. Army Research Institute of Environmental

Combating Wear of ASTM A36 Steel by Surface Modification Using Thermally Sprayed Cermet Coatings

OpenAIRE

Shibe, Vineet; Chawla, Vikas

2016-01-01

Thermal spray coatings can be applied economically on machine parts to enhance their requisite surface properties like wear, corrosion, erosion resistance, and so forth. Detonation gun (D-Gun) thermal spray coatings can be applied on the surface of carbon steels to improve their wear resistance. In the present study, alloy powder cermet coatings WC-12% Co and Cr3C2-25% NiCr have been deposited on ASTM A36 steel with D-Gun thermal spray technique. Sliding wear behavior of uncoated ASTM A36 ste...

ASTM Validates Air Pollution Test Methods

Science.gov (United States)

Chemical and Engineering News, 1973

1973-01-01

The American Society for Testing and Materials (ASTM) has validated six basic methods for measuring pollutants in ambient air as the first part of its Project Threshold. Aim of the project is to establish nationwide consistency in measuring pollutants; determining precision, accuracy and reproducibility of 35 standard measuring methods. (BL)

Association between F508 deletion in CFTR and chronic pancreatitis risk.

Science.gov (United States)

Zhao, Dong; Xu, Yanzhen; Li, Jiatong; Fu, Shien; Xiao, Feifan; Song, Xiaowei; Xie, Zhibin; Jiang, Min; He, Yan; Liu, Chengwu; Wen, Qiongxian; Yang, Xiaoli

2017-09-01

The cystic fibrosis transmembrane conductance regulator (CFTR) has been reported to influence individual susceptibility to chronic pancreatitis (CP), but the results of previous studies are controversial. We performed a study to demonstrate the relationship between CFTR and CP. We searched PubMed, Scopus, and Embase for studies of patients with CP. Seven studies from 1995 to 2016 were identified, and included 64,832 patients. Pooled prevalence and 95% confidence intervals (CIs) were calculated. F508 deletion in CFTR was significantly positively associated with CP risk in the overall analysis (odds ratio [OR]=3.20, 95% CI: 2.30-4.44, I 2 =31.7%). In subgroup analysis stratified by ethnicity, F508 deletion was significantly associated with CP risk in Indian populations, using a fixed effects model (ORs=5.45, 95% CI: 2.52-11.79, I 2 =0.0%), and in non-Indian populations, using a random effects model (ORs=3.59, 95% CI: 1.73-7.48, I 2 =60.9%). At the same time, we found that Indians with F508 deletion had much higher CP prevalence than non-Indians. Interestingly, F508 deletion was also associated with CP and idiopathic CP risk in subgroup analysis stratified by aeitiology, using the fixed effects model. Based on current evidence, F508 deletion is a risk factor for CP, and Indians with F508 deletion have much higher CP morbidity. Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

A Family of ACO Routing Protocols for Mobile Ad Hoc Networks

Science.gov (United States)

Rupérez Cañas, Delfín; Sandoval Orozco, Ana Lucila; García Villalba, Luis Javier; Kim, Tai-hoon

2017-01-01

In this work, an ACO routing protocol for mobile ad hoc networks based on AntHocNet is specified. As its predecessor, this new protocol, called AntOR, is hybrid in the sense that it contains elements from both reactive and proactive routing. Specifically, it combines a reactive route setup process with a proactive route maintenance and improvement process. Key aspects of the AntOR protocol are the disjoint-link and disjoint-node routes, separation between the regular pheromone and the virtual pheromone in the diffusion process and the exploration of routes, taking into consideration the number of hops in the best routes. In this work, a family of ACO routing protocols based on AntOR is also specified. These protocols are based on protocol successive refinements. In this work, we also present a parallelized version of AntOR that we call PAntOR. Using programming multiprocessor architectures based on the shared memory protocol, PAntOR allows running tasks in parallel using threads. This parallelization is applicable in the route setup phase, route local repair process and link failure notification. In addition, a variant of PAntOR that consists of having more than one interface, which we call PAntOR-MI (PAntOR-Multiple Interface), is specified. This approach parallelizes the sending of broadcast messages by interface through threads. PMID:28531159

A Family of ACO Routing Protocols for Mobile Ad Hoc Networks.

Science.gov (United States)

Rupérez Cañas, Delfín; Sandoval Orozco, Ana Lucila; García Villalba, Luis Javier; Kim, Tai-Hoon

2017-05-22

In this work, an ACO routing protocol for mobile ad hoc networks based on AntHocNet is specified. As its predecessor, this new protocol, called AntOR, is hybrid in the sense that it contains elements from both reactive and proactive routing. Specifically, it combines a reactive route setup process with a proactive route maintenance and improvement process. Key aspects of the AntOR protocol are the disjoint-link and disjoint-node routes, separation between the regular pheromone and the virtual pheromone in the diffusion process and the exploration of routes, taking into consideration the number of hops in the best routes. In this work, a family of ACO routing protocols based on AntOR is also specified. These protocols are based on protocol successive refinements. In this work, we also present a parallelized version of AntOR that we call PAntOR. Using programming multiprocessor architectures based on the shared memory protocol, PAntOR allows running tasks in parallel using threads. This parallelization is applicable in the route setup phase, route local repair process and link failure notification. In addition, a variant of PAntOR that consists of having more than one interface, which we call PAntOR-MI (PAntOR-Multiple Interface), is specified. This approach parallelizes the sending of broadcast messages by interface through threads.

Effect of long term thermal ageing on the mechanical properties of ASTM A533B and A508 steels in the quenched and tempered and simulated heat affected zone conditions

Energy Technology Data Exchange (ETDEWEB)

Druce, S.G.; Gage, G.; Jordan, G.

1985-04-01

Manganese-molybdenum-nickel steels are used commonly in the fabrication of critical components in the PWR primary circuit operating at temperatures up to 345 C for periods up to several hundred thousand hours. Demonstration of structural integrity throughout service life requires quantification of the effects of thermal ageing on mechanical properties. Thermal ageing in the temperature range 300 to 550 C for durations up to 2000 h was studied in quenched and tempered A533B plate and simulated heat-affected-zone (HAZ) microstructures in A533B and A508 materials. A combination of tensile, hardness and Charpy impact tests were used to assess changes in rheological and toughness related properties. Quantitative fractography and Auger spectroscopy were used to characterize associated changes in fracture mode and grain boundary composition.

Verification of the ASTM G-124 Purge Equation

Science.gov (United States)

Robbins, Katherine E.; Davis, Samuel Eddie

2009-01-01

ASTM G-124 seeks to evaluate combustion characteristics of metals in high-purity (greater than 99%) oxygen atmospheres. ASTM G-124 provides the following equation to determine the minimum number of purges required to reach this level of purity in a test chamber: n = -4/log10(Pa/Ph), where "n" is the total number of purge cycles required, Ph is the absolute pressure used for the purge on each cycle and Pa is the atmospheric pressure or the vent pressure. The origin of this equation is not known and has been the source of frequent questions as to its accuracy and reliability. This paper shows the derivation of the G-124 purge equation, and experimentally explores the equation to determine if it accurately predicts the number of cycles required.

76 FR 1459 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ASTM International

Science.gov (United States)

2011-01-10

... Production Act of 1993-ASTM International Notice is hereby given that, on December 6, 2010, pursuant to.... (``the Act''), ASTM International (``ASTM'') has filed written notifications simultaneously with the...

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.

Directory of Open Access Journals (Sweden)

Guido Veit

2016-05-01

Full Text Available The most common cystic fibrosis (CF causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del, results in functional expression defect of the CF transmembrane conductance regulator (CFTR at the apical plasma membrane (PM of secretory epithelia, which is attributed to the degradation of the misfolded channel at the endoplasmic reticulum (ER. Deletion of phenylalanine 670 (ΔF670 in the yeast oligomycin resistance 1 gene (YOR1, an ABC transporter of Saccharomyces cerevisiae phenocopies the ΔF508-CFTR folding and trafficking defects. Genome-wide phenotypic (phenomic analysis of the Yor1-ΔF670 biogenesis identified several modifier genes of mRNA processing and translation, which conferred oligomycin resistance to yeast. Silencing of orthologues of these candidate genes enhanced the ΔF508-CFTR functional expression at the apical PM in human CF bronchial epithelia. Although knockdown of RPL12, a component of the ribosomal stalk, attenuated the translational elongation rate, it increased the folding efficiency as well as the conformational stability of the ΔF508-CFTR, manifesting in 3-fold augmented PM density and function of the mutant. Combination of RPL12 knockdown with the corrector drug, VX-809 (lumacaftor restored the mutant function to ~50% of the wild-type channel in primary CFTRΔF508/ΔF508 human bronchial epithelia. These results and the observation that silencing of other ribosomal stalk proteins partially rescue the loss-of-function phenotype of ΔF508-CFTR suggest that the ribosomal stalk modulates the folding efficiency of the mutant and is a potential therapeutic target for correction of the ΔF508-CFTR folding defect.

Expression Study of LeGAPDH, LeACO1, LeACS1A, and LeACS2 in Tomato Fruit (Solanum lycopersicum

Directory of Open Access Journals (Sweden)

Pijar Riza Anugerah

2015-10-01

Full Text Available Tomato is a climacteric fruit, which is characterized by ripening-related increase of respiration and elevated ethylene synthesis. Ethylene is the key hormone in ripening process of climacteric fruits. The objective of this research is to study the expression of three ethylene synthesis genes: LeACO1, LeACS1A, LeACS2, and a housekeeping gene LeGAPDH in ripening tomato fruit. Specific primers have been designed to amplify complementary DNA fragment of LeGAPDH (143 bp, LeACO1 (240 bp, LeACS1A (169 bp, and LeACS2 (148 bp using polymerase chain reaction. Nucleotide BLAST results of the complementary DNA fragments show high similarity with LeGAPDH (NM_001247874.1, LeACO1 (NM_001247095.1, LeACS1A (NM_001246993.1, LeACS2 (NM_001247249.1, respectively. Expression study showed that LeACO1, LeACS1A, LeACS2, and LeGAPDH genes were expressed in ripening tomato fruit. Isolation methods, reference sequences, and primers used in this study can be used in future experiments to study expression of genes responsible for ethylene synthesis using quantitative polymerase chain reaction and to design better strategy for controlling fruit ripening in agroindustry.

Microstructure of a safe-end dissimilar metal weld joint (SA508-52-316L) prepared by narrow-gap GTAW

Energy Technology Data Exchange (ETDEWEB)

Ming, Hongliang [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning Key Laboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049 (China); Zhang, Zhiming [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning Key Laboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Wang, Jianqiu, E-mail: wangjianqiu@imr.ac.cn [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning Key Laboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Han, En-Hou [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning Key Laboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Wang, Peipei; Sun, Zhiyuan [Shanghai Research Center for Weld and Detection Engineering Technique of Nuclear Equipment, Shanghai 201306 (China)

2017-01-15

The microstructure, residual strain and interfacial chemical composition distribution of a safe-end dissimilar metal weld joint (DMWJ, SA508-52-316L) prepared by narrow-gap gas-tungsten arc welding (NG-GTAW) were studied by optical microscope (OM) and scanning electron microscope equipped with an energy dispersive X-ray microanalysis (SEM/EDX) and an electron back scattering diffraction (EBSD) system. Complex microstructure and chemical composition distribution are found, especially at the SA508-52 interface and the 52-316L interface. In brief, a complicated microstructure transition exists within the SA508 heat affected zone (HAZ); the residual strain, the fraction of high angle random grain boundaries and low angle boundaries decrease with increasing the distance from the fusion boundary in 316L HAZ; neither typical type II boundary nor obvious carbon-depleted zone is found near the SA508-52 interface; dramatic and complicated changes of the contents of the main elements, Fe, Cr and Ni, are observed at the distinct interfaces, especially at the SA508-52 interface. No carbon concentration is found at the SA508-52 interface. - Highlights: •Residual strain and GBCD change as a function of the distance from FB in 316L HAZ. •Neither type II boundary nor obvious carbon-depleted zone is found in SA508 HAZ. •No carbon concentration is found at the SA508-52 interface. •The middle part of the DMWJ has the highest residual strain.

Evaluation of Instrumentation for Measuring Undissolved Water in Aviation Turbine Fuels per ASTM D3240

Science.gov (United States)

2015-11-05

Undissolved Water in Aviation Turbine Fuels per ASTM D3240 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Joel Schmitigal... water ) in Aviation Turbine Fuels per ASTM D3240 15. SUBJECT TERMS fuel, JP-8, aviation fuel, contamination, free water , undissolved water , Aqua-Glo 16...Michigan 48397-5000 Evaluation of Instrumentation for Measuring Undissolved Water in Aviation Turbine Fuels per ASTM D3240 Joel Schmitigal Force

TP508 accelerates fracture repair by promoting cell growth over cell death

International Nuclear Information System (INIS)

Li Xinmin; Wang Hali; Touma, Edward; Qi Yuchen; Rousseau, Emma; Quigg, Richard J.; Ryaby, James T.

2007-01-01

TP508 is a synthetic 23-amino acid peptide representing a receptor-binding domain of human thrombin. We have previously shown that a single injection of TP508 accelerates fracture healing in a rat femoral fracture model. To understand how TP508 acts at the protein level during fracture healing, we compared the translational profiles between saline-control and fractured femur at six time points after TP508 treatment using the second generation of BD Clontech TM Antibody Microarray. Here, we demonstrate that TP508 accelerates fracture healing by modulating expression levels of proteins primarily involved in the functional categories of cell cycle, cellular growth and proliferation, and cell death. The majority of those proteins are physically interrelated and functionally overlapped. The action of those proteins is highlighted by a central theme of promoting cell growth via balance of cell survival over cell death signals. This appears to occur through the stimulation of several bone healing pathways including cell cycle-G1/S checkpoint regulation, apoptosis, JAK/STAT, NF-κB, PDGF, PI3K/AKT, PTEN, and ERK/MAPK

The development and psychometric validation of an instrument to evaluate nurses' attitudes towards communication with the patient (ACO).

Science.gov (United States)

Giménez-Espert, María Del Carmen; Prado-Gascó, Vicente Javier

2018-05-01

Patient communication is a key skill for nurses involved in clinical care. Its measurement is a complex phenomenon that can be addressed through attitude evaluation. To develop and psychometrically test a measure of nurses' attitudes towards communication with patients (ACO), to study the relationship between these dimensions, and to analyse nursing attitudes. To develop and psychometrically test the ACO questionnaire. All hospitals in the province of Valencia were invited by e-mail to distribute the ACO instrument. Ten hospitals took part in the study. The study population was composed of a convenience sample of 400 hospital nurses on general or special services. The inclusion criteria were nurses at the selected centres who had previously provided an informed consent to participate. A literature review and expert consultation (N = 10) was used to develop the content of the questionnaire. The 62-item version of the instrument was applied to a convenience sample of 400 nurses between May 2015 and March 2016. Factor structure was evaluated with exploratory and confirmatory factor analysis (EFA, CFA), and reliability was evaluated with Cronbach's alpha, composite reliability (CR), and average variance extracted (AVE). The final instrument (ACO), composed of 25 items grouped into three attitude dimensions (cognitive, affective and behavioural), had good psychometric properties. In the study sample, nurses had a favourable attitude towards communication. The cognitive and affective dimensions of the ACO should be able to predict the behaviour dimension. The ACO is useful for evaluating current clinical practices, identifying educational needs and assessing the effectiveness of communication training or other interventions intended to improve communication. Copyright © 2018 Elsevier Ltd. All rights reserved.

Implementation of a Pilot ACO Payment Model and the Use of Discretionary and Non-Discretionary Cardiovascular Care

Science.gov (United States)

Colla, Carrie. H.; Goodney, Philip P.; Lewis, Valerie A.; Nallamothu, Brahmajee K.; Gottlieb, Daniel J.; Meara, Ellen R.

2014-01-01

Background Accountable care organizations (ACOs) seek to reduce growth in healthcare spending while ensuring high-quality care. We hypothesized that ACO implementation would selectively limit utilization of discretionary cardiovascular care (defined as care occurring in the absence of indications such as myocardial infarction or stroke), while maintaining high-quality care such as non-discretionary cardiovascular imaging and procedures. Methods and Results The intervention group was composed of fee-for-service Medicare patients (n=819,779) from 10 groups participating in a Medicare pilot ACO, the Physician Group Practice Demonstration (PGPD). Matched controls were patients (n=934,621) from non-participating groups in the same regions. We compared utilization of cardiovascular care before (2002-2004) and after (2005-2009) PGPD implementation, studying both discretionary and non-discretionary carotid and coronary imaging and procedures. Our main outcome measure was the difference in the proportion of patients treated with imaging and procedures, among patients of PGPD practices compared to patients in control practices, before and after PGPD implementation (difference-in-difference). For discretionary imaging, the difference-in-difference between PGPD practices and controls was not statistically significant for discretionary carotid imaging (0.17%; 95% CI -0.51% to 0.85%, p=0.595) or discretionary coronary imaging (-0.19%; 95% CI -0.73% to 0.35%, p=0.468). Similarly, the difference-in-difference was also minimal for discretionary carotid revascularization (0.003%; 95% CI -0.008% to 0.002%, p=0.705) and coronary revascularization (-0.02%, 95% CI -0.11% to 0.07%, p=0.06). The difference-in-difference associated with PGPD implementation was also essentially zero for non-discretionary cardiovascular imaging or procedures. Conclusions Implementation of a pilot ACO did not limit the utilization of discretionary or non-discretionary cardiovascular care in ten large health

30 CFR 77.508-1 - Lightning arresters; wires entering buildings.

Science.gov (United States)

2010-07-01

.... 77.508-1 Section 77.508-1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS, SURFACE COAL MINES AND SURFACE WORK AREAS... buildings. Lightning arresters protecting exposed telephone wires entering buildings shall be provided at...

178. Linfoma cardíaco. Una neoplasia infrecuente

Directory of Open Access Journals (Sweden)

E. Sandoval

2010-01-01

Conclusiones: Los linfomas cardíacos son de alto grado de agresividad. La localización principal es la aurícula derecha, con clínica inespecífica y variable. No existe claro consenso sobre el tratamiento de elección, pero parece haber mayor supervivencia con tratamiento combinado con quimioterapia con antraciclínicos y radioterapia.

Processing time tolerance-based ACO algorithm for solving job-shop scheduling problem

Science.gov (United States)

Luo, Yabo; Waden, Yongo P.

2017-06-01

Ordinarily, Job Shop Scheduling Problem (JSSP) is known as NP-hard problem which has uncertainty and complexity that cannot be handled by a linear method. Thus, currently studies on JSSP are concentrated mainly on applying different methods of improving the heuristics for optimizing the JSSP. However, there still exist many problems for efficient optimization in the JSSP, namely, low efficiency and poor reliability, which can easily trap the optimization process of JSSP into local optima. Therefore, to solve this problem, a study on Ant Colony Optimization (ACO) algorithm combined with constraint handling tactics is carried out in this paper. Further, the problem is subdivided into three parts: (1) Analysis of processing time tolerance-based constraint features in the JSSP which is performed by the constraint satisfying model; (2) Satisfying the constraints by considering the consistency technology and the constraint spreading algorithm in order to improve the performance of ACO algorithm. Hence, the JSSP model based on the improved ACO algorithm is constructed; (3) The effectiveness of the proposed method based on reliability and efficiency is shown through comparative experiments which are performed on benchmark problems. Consequently, the results obtained by the proposed method are better, and the applied technique can be used in optimizing JSSP.

20 CFR 404.508 - Defeat the purpose of Title II.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Defeat the purpose of Title II. 404.508 Section 404.508 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... and necessary expenses include: (1) Fixed living expenses, such as food and clothing, rent, mortgage...

Optimization of reload of nuclear power plants using ACO together with the GENES reactor physics code

Energy Technology Data Exchange (ETDEWEB)

Lima, Alan M.M. de; Freire, Fernando S.; Nicolau, Andressa S.; Schirru, Roberto, E-mail: alan@lmp.ufrj.br, E-mail: andressa@lmp.ufrj.br, E-mail: schirru@lmp.ufrj.br, E-mail: ffreire@eletronuclear.gov.br [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (PEN/COPPE/UFRJ), Rio de Janeiro, RJ (Brazil); Eletrobras Termonuclear S.A. (ELETRONUCLEAR), Rio de Janeiro, RJ (Brazil)

2017-11-01

The Nuclear reload of a Pressurized Water Reactor (PWR) occurs whenever the burning of the fuel elements can no longer maintain the criticality of the reactor, that is, it cannot maintain the Nuclear power plant operates within its nominal power. Nuclear reactor reload optimization problem consists of finding a loading pattern of fuel assemblies in the reactor core in order to minimize the cost/benefit ratio, trying to obtain maximum power generation with a minimum of cost, since in all reloads an average of one third of the new fuel elements are purchased. This loading pattern must also satisfy constraints of symmetry and security. In practice, it consists of the placing 121 fuel elements in 121 core positions, in the case of the Angra 1 Brazilian Nuclear Power Plant (NPP), making this new arrangement provide the best cost/benefit ratio. It is an extremely complex problem, since it has around 1% of great places. A core of 121 fuel elements has approximately 10{sup 13} combinations and 10{sup 11} great locations. With this number of possible combinations it is impossible to test all, in order to choose the best. In this work a system called ACO-GENES is proposed in order to optimization the Nuclear Reactor Reload Problem. ACO is successfully used in combination problems, and it is expected that ACO-GENES will show a robust optimization system, since in addition to optimizing ACO, it allows important prior knowledge such as K infinite, burn, etc. After optimization by ACO-GENES, the best results will be validated by a licensed reactor physics code and will be compared with the actual results of the cycle. (author)

Optimization of reload of nuclear power plants using ACO together with the GENES reactor physics code

International Nuclear Information System (INIS)

Lima, Alan M.M. de; Freire, Fernando S.; Nicolau, Andressa S.; Schirru, Roberto

2017-01-01

The Nuclear reload of a Pressurized Water Reactor (PWR) occurs whenever the burning of the fuel elements can no longer maintain the criticality of the reactor, that is, it cannot maintain the Nuclear power plant operates within its nominal power. Nuclear reactor reload optimization problem consists of finding a loading pattern of fuel assemblies in the reactor core in order to minimize the cost/benefit ratio, trying to obtain maximum power generation with a minimum of cost, since in all reloads an average of one third of the new fuel elements are purchased. This loading pattern must also satisfy constraints of symmetry and security. In practice, it consists of the placing 121 fuel elements in 121 core positions, in the case of the Angra 1 Brazilian Nuclear Power Plant (NPP), making this new arrangement provide the best cost/benefit ratio. It is an extremely complex problem, since it has around 1% of great places. A core of 121 fuel elements has approximately 10"1"3 combinations and 10"1"1 great locations. With this number of possible combinations it is impossible to test all, in order to choose the best. In this work a system called ACO-GENES is proposed in order to optimization the Nuclear Reactor Reload Problem. ACO is successfully used in combination problems, and it is expected that ACO-GENES will show a robust optimization system, since in addition to optimizing ACO, it allows important prior knowledge such as K infinite, burn, etc. After optimization by ACO-GENES, the best results will be validated by a licensed reactor physics code and will be compared with the actual results of the cycle. (author)

HACCP: Integrating Science and Management through ASTM Standards

Science.gov (United States)

From a technical perspective, hazard analysis-critical control point (HACCP) evaluation may be considered a risk management tool suited to a wide range of applications. As one outcome of a symposium convened by American Society for Testing and Materials (ASTM) in August, 2005, th...

Cystic fibrosis Delta F508 heterozygotes, smoking, and reproduction

DEFF Research Database (Denmark)

Dahl, Morten; Tybjaerg-Hansen, A; Wittrup, H H

1998-01-01

Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested this hypot......Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested.......001). In conclusion, overall these results do not support a reproductive advantage for cystic fibrosis DeltaF508 heterozygotes. However, the data cannot totally exclude the possibility that nonsmoking DeltaF508 heterozygotes experience a reproductive advantage while smoking DeltaF508 heterozygotes experience...... the opposite, a reproductive disadvantage. Accordingly, the data suggest a previously undocumented role of smoking on fecundity among cystic fibrosis heterozygotes....

24 CFR 5.508 - Submission of evidence of citizenship or eligible immigration status.

Science.gov (United States)

2010-04-01

... citizenship or eligible immigration status. 5.508 Section 5.508 Housing and Urban Development Office of the... Restrictions on Assistance to Noncitizens § 5.508 Submission of evidence of citizenship or eligible immigration... or eligible immigration status, the family members may exercise the election not to contend to have...

Topology in two dimensions. II - The Abell and ACO cluster catalogues

Science.gov (United States)

Plionis, Manolis; Valdarnini, Riccardo; Coles, Peter

1992-09-01

We apply a method for quantifying the topology of projected galaxy clustering to the Abell and ACO catalogues of rich clusters. We use numerical simulations to quantify the statistical bias involved in using high peaks to define the large-scale structure, and we use the results obtained to correct our observational determinations for this known selection effect and also for possible errors introduced by boundary effects. We find that the Abell cluster sample is consistent with clusters being identified with high peaks of a Gaussian random field, but that the ACO shows a slight meatball shift away from the Gaussian behavior over and above that expected purely from the high-peak selection. The most conservative explanation of this effect is that it is caused by some artefact of the procedure used to select the clusters in the two samples.

Use of ASTM D5304 in assessing unstable diesel fuel

Energy Technology Data Exchange (ETDEWEB)

Turner, L.M.; Martin, C.J. [Defense Fuel Supply Center, Alexandria, VA (United States); Beal, E.J.; Hardy, D.R. [Naval Research Lab., Washington, DC (United States)

1995-05-01

The storage stability, or the length of time a fuel can be stored, is of great concern to diesel fuel users. This paper reports on the use of the new ASTM accelerated test for storage stability by oxygen overpressure (D5304) to predict future storage life span of 63,000,000 gallons of a diesel fuel for US Naval vessel use. This paper demonstrates the use of ASTM D5304 at storage times of 16, 40 and 96 hours to accurately determine the length of time that this large quantity of diesel fuel could be stored at ambient temperatures before the maximum allowable amount of particulate contamination was reached.

19 CFR 351.508 - Debt forgiveness.

Science.gov (United States)

2010-04-01

... Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Identification and Measurement of Countervailable Subsidies § 351.508 Debt forgiveness. (a) Benefit. In the case of an assumption or forgiveness of a firm's debt obligation, a benefit exists equal to the amount of...

31 CFR 50.8 - Procedure for requesting determinations of controlling influence.

Science.gov (United States)

2010-07-01

... determinations of controlling influence. 50.8 Section 50.8 Money and Finance: Treasury Office of the Secretary of... determinations of controlling influence. (a) An insurer or insurers not having control over another insurer under... controlling influence under § 50.5(c)(4)(i) through (iv) or otherwise to request a determination of...

Standardization work by ASTM and DIN concerning test methods for metallic materials - comparative assessment with regard for practice

International Nuclear Information System (INIS)

Gerischer, K.

1986-01-01

The article explains the significant role of ASTM and marks out basic elements of the specification system of ASTM standards. Usefulness in practice is taken as the main criterion for the subsequent comparison of ASTM or DIN activities and procedures, and results, for standardization in the field of test methods for metallic materials. The main differences are shown to exist with regard to tropicality of test standards, presentation of useful information and background knowledge, and importance attached to formal questions. ASTM standardization work is shown to be more up-to-date, contain more information, and to be less concerned with formal matters. A closer cooperation between ASTM and DIN is strongly recommended. (orig.) [de

Betting on change: Tenet deal with Vanguard shows it's primed to try ACO effort, new payment model.

Science.gov (United States)

Kutscher, Beth

2013-07-01

Tenet Healthcare Corp.'s acquisition of Vanguard Health Systems is a sign the investor-owned chain is willing to take a chance on alternative payment models such as accountable care organizations. There's no certainty that ACOs will deliver the improvements on quality or cost savings, but Vanguard Vice Chairman Keith Pitts, left, says his system's Pioneer ACO in Detroit has already achieved some cost savings.

Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis.

Science.gov (United States)

Esposito, Speranza; Tosco, Antonella; Villella, Valeria R; Raia, Valeria; Kroemer, Guido; Maiuri, Luigi

2016-12-01

Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concentrations, progressive lung disease with chronic inflammation and recurrent bacterial infections, pancreatic insufficiency, and male infertility. Therapies aimed at restoring the CFTR defect have emerged. Thus, a small molecule which facilitates chloride channel opening, the potentiator Ivacaftor, has been approved for the treatment of CF patients bearing a particular class of rare CFTR mutations. However, small molecules that directly target the most common misfolded CFTR mutant, F508del, and improve its intracellular trafficking in vitro, have been less effective than expected when tested in CF patients, even in combination with Ivacaftor. Thus, new strategies are required to circumvent the F508del-CFTR defect. Airway and intestinal epithelial cells from CF patients bearing the F508del-CFTR mutation exhibit an impressive derangement of cellular proteostasis, with oxidative stress, overactivation of the tissue transglutaminase (TG2), and disabled autophagy. Proteostasis regulators such as cysteamine can rescue and stabilize a functional F508del-CFTR protein through suppressing TG2 activation and restoring autophagy in vivo in F508del-CFTR homozygous mice, in vitro in CF patient-derived cell lines, ex vivo in freshly collected primary patient's nasal cells, as well as in a pilot clinical trial involving homozygous F508del-CFTR patients. Here, we discuss how the therapeutic normalization of defective proteostasis can be harnessed for the treatment of CF patients with the F508del-CFTR mutation.

Sedação com sufentanil e clonidina em pacientes submetidos a cateterismo cardíaco

Directory of Open Access Journals (Sweden)

Anita Perpetua Carvalho Rocha

2011-03-01

Full Text Available FUNDAMENTO: A sedação para a realização de cateterismo cardíaco tem sido alvo de preocupação. Benzodiazepínicos, agonistas alfa-2 adrenérgicos e opioides são utilizados para esse fim, entretanto, cada um destes medicamentos possui vantagens e desvantagens. OBJETIVO: Avaliar a eficácia do sufentanil e da clonidina como sedativos em pacientes submetidos a cateterismo cardíaco, observando o impacto dos mesmos sobre os parâmetros hemodinâmicos e respiratórios, a presença de efeitos colaterais, além da satisfação do paciente e do hemodinamicista com o exame. MÉTODOS: Trata-se de um ensaio clínico prospectivo, duplo-cego, randomizado e controlado, que envolveu 60 pacientes que receberam 0,1 µg/kg de sufentanil ou 0,5 µg/kg de clonidina antes da realização do cateterismo cardíaco. O escore de sedação segundo a escala de Ramsay, a necessidade de utilização de midazolam, os efeitos colaterais, os parâmetros hemodinâmicos e respiratórios foram registrados, sendo os dados analisados em 06 diferentes momentos. RESULTADOS: O comportamento da pressão arterial, da frequência cardíaca e da frequência respiratória foi semelhante nos dois grupos, entretanto, no momento 2, os pacientes do grupo sufentanil (Grupo S apresentaram menor escore de sedação segundo a escala de Ramsay, e a saturação periférica da oxihemoglobina foi menor que o grupo clonidina (Grupo C no momento 6. Os pacientes do Grupo S apresentaram maior incidência de náusea e vômito pós-operatório que os pacientes do Grupo C. A satisfação dos pacientes foi maior no grupo clonidina. Os hemodinamicistas mostraram-se satisfeitos nos dois grupos. CONCLUSÃO: O sufentanil e a clonidina foram efetivos como sedativos em pacientes submetidos a cateterismo cardíaco.

Section 508 Electronic Information Accessibility Requirements for Software Development

Science.gov (United States)

Ellis, Rebecca

2014-01-01

Section 508 Subpart B 1194.21 outlines requirements for operating system and software development in order to create a product that is accessible to users with various disabilities. This portion of Section 508 contains a variety of standards to enable those using assistive technology and with visual, hearing, cognitive and motor difficulties to access all information provided in software. The focus on requirements was limited to the Microsoft Windows® operating system as it is the predominant operating system used at this center. Compliance with this portion of the requirements can be obtained by integrating the requirements into the software development cycle early and by remediating issues in legacy software if possible. There are certain circumstances with software that may arise necessitating an exemption from these requirements, such as design or engineering software using dynamically changing graphics or numbers to convey information. These exceptions can be discussed with the Section 508 Coordinator and another method of accommodation used.

Fifteen-year follow-up of pulmonary function in individuals heterozygous for the cystic fibrosis phenylalanine-508 deletion

DEFF Research Database (Denmark)

Dahl, Morten; Nordestgaard, B G; Lange, P

2001-01-01

In a cross-sectional study, we previously showed that cystic fibrosis phenylalanine-508 deletion (DeltaF508) heterozygosity may be overrepresented among individuals with asthma.......In a cross-sectional study, we previously showed that cystic fibrosis phenylalanine-508 deletion (DeltaF508) heterozygosity may be overrepresented among individuals with asthma....

Protocolo del manejo y selección del donante cardíaco

Directory of Open Access Journals (Sweden)

José Elizalde

2008-01-01

Full Text Available El trasplante cardíaco es una terapia aceptada en grupos de pacientes afectos de insuficiencia cardíaca terminal. El envejecimiento progresivo de los donantes y la reducción del número de traumatismos craneoencefálicos mortales obliga a una valoración exhaustiva en cada caso. La ecocardiografía es, hoy en día, una exploración obligada en la valoración del donante. La Organización Nacional de Trasplantes ha elaborado un protocolo de manejo del donante torácico para optimizar su aprovechamiento. Se revisan los criterios de selección del donante cardíaco insistiendo en las contraindicaciones, en el despistaje de enfermedad coronaria y el mantenimiento durante el proceso de selección.

Creep of A508/533 Pressure Vessel Steel

Energy Technology Data Exchange (ETDEWEB)

Richard Wright

2014-08-01

ABSTRACT Evaluation of potential Reactor Pressure Vessel (RPV) steels has been carried out as part of the pre-conceptual Very High Temperature Reactor (VHTR) design studies. These design studies have generally focused on American Society of Mechanical Engineers (ASME) Code status of the steels, temperature limits, and allowable stresses. Initially, three candidate materials were identified by this process: conventional light water reactor (LWR) RPV steels A508 and A533, 2¼Cr-1Mo in the annealed condition, and Grade 91 steel. The low strength of 2¼Cr-1Mo at elevated temperature has eliminated this steel from serious consideration as the VHTR RPV candidate material. Discussions with the very few vendors that can potentially produce large forgings for nuclear pressure vessels indicate a strong preference for conventional LWR steels. This preference is based in part on extensive experience with forging these steels for nuclear components. It is also based on the inability to cast large ingots of the Grade 91 steel due to segregation during ingot solidification, thus restricting the possible mass of forging components and increasing the amount of welding required for completion of the RPV. Grade 91 steel is also prone to weld cracking and must be post-weld heat treated to ensure adequate high-temperature strength. There are also questions about the ability to produce, and very importantly, verify the through thickness properties of thick sections of Grade 91 material. The availability of large components, ease of fabrication, and nuclear service experience with the A508 and A533 steels strongly favor their use in the RPV for the VHTR. Lowering the gas outlet temperature for the VHTR to 750°C from 950 to 1000°C, proposed in early concept studies, further strengthens the justification for this material selection. This steel is allowed in the ASME Boiler and Pressure Vessel Code for nuclear service up to 371°C (700°F); certain excursions above that temperature are

Dynamic Fuzzy Logic Parameter Tuning for ACO and Its Application in the Fuzzy Logic Control of an Autonomous Mobile Robot

Directory of Open Access Journals (Sweden)

Oscar Castillo

2013-01-01

Full Text Available Ant Colony Optimization (ACO is a population-based constructive meta-heuristic that exploits a form of past performance memory inspired by the foraging behaviour of real ants. The behaviour of the ACO algorithm is highly dependent on the values defined for its parameters. Adaptation and parameter control are recurring themes in the field of bio-inspired algorithms. The present paper explores a new approach to diversity control in ACO. The central idea is to avoid or slow down full convergence through the dynamic variation of certain parameters. The performance of different variants of the ACO algorithm was observed to choose one as the basis for the proposed approach. A convergence fuzzy logic controller with the objective of maintaining diversity at some level to avoid premature convergence was created. Encouraging results have been obtained on its application to the design of fuzzy controllers. In particular, the optimization of membership functions for a unicycle mobile robot trajectory control is presented with the proposed method.

Trasplante cardíaco pediátrico: pasado, presente y futuro

Directory of Open Access Journals (Sweden)

María-Teresa González-López

2017-01-01

Conclusión: El trasplante cardíaco pediátrico presenta óptimos resultados en nuestro medio, superponibles a series mundiales. Aunque el perfil de riesgo está incrementándose, los resultados actuales reflejan los avances en el manejo de estos pacientes.

Sources of Confusion in the Determination of ASTM Repetitive Member Factors for the Allowable Properties of Wood Products

Science.gov (United States)

S. Verrill; D. Kretschmann

2012-01-01

It is generally accepted that there should be an upward repetitive member allowable property adjustment. ASTM D245 (2011c) and ASTM D1990 (2011b) specify a 1.15 factor for allowable bending stress. This factor is also listed in ASTM D6555 (2011a, Table 1). In this technical note, sources of confusion regarding appropriate repetitive member factors are identified. This...

Silencing of ACO decreases reproduction and energy metabolism in triazophos-treated female brown plant hoppers, Nilaparvata lugens Stål (Hemiptera: Delphacidae).

Science.gov (United States)

Liu, Zong-Yu; Jiang, Yi-Ping; Li, Lei; You, Lin-Lin; Wu, You; Xu, Bin; Ge, Lin-Quan; Wu, Jin-Cai

2016-03-01

The brown plant hopper (BPH), Nilaparvata lugens Stål (Hemiptera: Delphacidae), is a major pest affecting rice in Asia, and outbreaks of this pest are closely linked to pesticide-induced stimulation of reproduction. Therefore, the BPH is a classic example of a resurgent pest. However, the effects of different genes on the regulation of pesticide-induced reproductive stimulation in the BPH are unclear. In this study, the regulatory effects of acyl-coenzyme A oxidase (ACO) on the reproduction and biochemistry of the BPH were investigated with gene silencing. The number of eggs laid per female by triazophos (TZP)+dsACO BPH females was significantly lower than those of TZP-treated (without ACO silencing) or TZP+GFP females (negative control), with the number of eggs decreasing by 30.8% (from 529.5 to 366.3) and 32.0% (from 540.5 to 366.3), respectively. The preoviposition period, oviposition period, and longevity of the TZP-treated females were also influenced by dsACO treatment. Additionally, the amounts of crude fat, protein, and some fatty acids (oleic acid, palmitic acid, linoleic acid, stearic acid, and myristoleic acid) in TZP+dsACO females were significantly lower than in TZP-treated females. Thus, ACO is one of the key genes regulating the TZP-induced stimulation of reproduction in BPH females. Copyright © 2015 Elsevier Inc. All rights reserved.

25 CFR 20.508 - What must the social services agency do when a child is placed in foster care, residential care...

Science.gov (United States)

2010-04-01

... PROGRAMS Child Assistance Foster Care § 20.508 What must the social services agency do when a child is placed in foster care, residential care or guardianship home? The social services agency must make... placed in foster care, residential care or guardianship home? 20.508 Section 20.508 Indians BUREAU OF...

Solving optimum operation of single pump unit problem with ant colony optimization (ACO) algorithm

International Nuclear Information System (INIS)

Yuan, Y; Liu, C

2012-01-01

For pumping stations, the effective scheduling of daily pump operations from solutions to the optimum design operation problem is one of the greatest potential areas for energy cost-savings, there are some difficulties in solving this problem with traditional optimization methods due to the multimodality of the solution region. In this case, an ACO model for optimum operation of pumping unit is proposed and the solution method by ants searching is presented by rationally setting the object function and constrained conditions. A weighted directed graph was constructed and feasible solutions may be found by iteratively searching of artificial ants, and then the optimal solution can be obtained by applying the rule of state transition and the pheromone updating. An example calculation was conducted and the minimum cost was found as 4.9979. The result of ant colony algorithm was compared with the result from dynamic programming or evolutionary solving method in commercial software under the same discrete condition. The result of ACO is better and the computing time is shorter which indicates that ACO algorithm can provide a high application value to the field of optimal operation of pumping stations and related fields.

Current situation of asthma-COPD overlap syndrome (ACOS) in Chinese patients older than 40 years with airflow limitation: rationale and design for a multicenter, cross-sectional trial (study protocol).

Science.gov (United States)

Kang, Jian; Yao, Wanzhen; Cai, Baiqiang; Chen, Ping; Ling, Xia; Shang, Hongyan

2016-12-01

Asthma and chronic obstructive pulmonary disease (COPD) are the frequently occurring chronic airway diseases, and the overlapping syndrome observed in the majority of patients has been recently defined as asthma-COPD overlap syndrome (ACOS) by the Global Initiative for Chronic Obstructive Lung (GOLD, 2014) and Global initiative for Asthma (GINA, 2015). The proportion, features, and clinical practice of ACOS still remain elusive in China. We are conducting this multicenter, cross-sectional, observational study (NCT02600221) to investigate the distributions of chronic obstructive diseases in patients >40 years of age with chronic airflow limitation in China along with determination of the main clinical practice and features of these diseases. The study will also explore the factors that may influence the exacerbations and severity of ACOS in Chinese patients (>40 years of age). A total of 2,000 patients (age, ≥40 years; either sex) who are clinically diagnosed as having asthma, COPD/chronic bronchitis/emphysema, or ACOS for at least 12 months with airflow limitation [post-bronchodilator forced expiratory volume in 1 second/forced vital capacity (FEV 1 /FVC): current situation, main clinical practice, and features of ACOS, asthma, and COPD conditions in Chinese patients. The insights will be helpful in designing optimal management strategies for ACOS and redefining the healthcare development programs.

Applications of UV-storage ring free electron lasers: the case of super-ACO

CERN Document Server

Nahon, L; Couprie, Marie Emmanuelle; Merola, F; Dumas, P; Marsi, M; Taleb-Ibrahimi, A; Nutarelli, D; Roux, R; Billardon, M

1999-01-01

The potential of UV-storage ring free electron lasers (SRFELs) for the performance of original application experiments is shown with a special emphasis concerning their combination with the naturally synchronized synchrotron radiation (SR). The first two-color FEL+SR experiment, performed in surface science at Super-ACO is reported. The experimental parameters found to be the most important as gathered from the acquired experience, are underlined and discussed. Finally, future prospects for the scientific program of the Super-ACO FEL are presented with two-color experiments combining the FEL with SR undulator-based XUV and VUV beamlines as well as with a SR white light bending magnet beamline emiting in the IR-UV (20 mu m-0.25 mu m).

Integration of Nanofluids into Commercial Antifreeze Concentrates with ASTM D15 Corrosion Testing

Science.gov (United States)

2013-05-01

Lockwood1 1 Valvoline New Product Development Laboratory, Ashland Consumer Markets , Lexington, Kentucky. 2 Tank Automotive Research, Development...Development Laboratory,Ashland Consumer Markets ,P.O. Box 14000,Lexington,KY,40512 8. PERFORMING ORGANIZATION REPORT NUMBER ; #23826 9. SPONSORING...Technology, Performance, and Life for Light-Duty Applications, Engine Coolant Testing: Fourth Volume, ASTM STP 1335, R.E. Beale ed., ASTM, Philadelphia

An Automated Safe-to-Mate (ASTM) Tester

Science.gov (United States)

Nguyen, Phuc; Scott, Michelle; Leung, Alan; Lin, Michael; Johnson, Thomas

2013-01-01

Safe-to-mate testing is a common hardware safety practice where impedance measurements are made on unpowered hardware to verify isolation, continuity, or impedance between pins of an interface connector. A computer-based instrumentation solution has been developed to resolve issues. The ASTM is connected to the circuit under test, and can then quickly, safely, and reliably safe-to-mate the entire connector, or even multiple connectors, at the same time.

NHETS - Estudo de Necrópsias de Pacientes Submetidos a Transplante Cardíaco

Directory of Open Access Journals (Sweden)

Thiago Ninck Valette

2014-06-01

Full Text Available Fundamento: Discordâncias entre diagnóstico pre e post-mortem são relatadas na literatura, podendo variar de 4,1 a 49,8% dentre os casos encaminhados para exame necroscópico, com importante repercussão no tratamento dos pacientes. Objetivo: Analisar pacientes com óbito após o transplante cardíaco e confrontar os diagnósticos pre e post-mortem. Métodos: Por meio da revisão de prontuários, foram analisados dados clínicos, presença de comorbidades, esquema de imunossupressão, exames laboratoriais, causa clínica do óbito e causa do óbito à necrópsia. Foram confrontadas, então, a causa clínica e a causa necroscópica do óbito de cada paciente. Resultados: Foram analisados 48 óbitos submetidos à necrópsia no período de 2000 a 2010; 29 (60,4% tiveram diagnósticos clínico e necroscópico concordantes, 16 (33,3% tiveram diagnósticos discordantes e três (6,3% tiveram diagnóstico não esclarecido. Entre os discordantes, 15 (31,3% apresentaram possível impacto na sobrevida e um (2,1% não apresentou impacto na sobrevida. O principal diagnóstico clínico feito equivocadamente foi o de infecção, com cinco casos (26,7% dos discordantes, seguido por rejeição hiperaguda, com quatro casos (20% dos discordantes, e tromboembolismo pulmonar, com três casos (13,3% dos discordantes. Conclusão: Discordâncias entre o diagnóstico clínico e achados da necrópsia são comumente encontradas no transplante cardíaco. Novas estratégias no aperfeiçoamento do diagnóstico clínico devem ser introduzidas, considerando-se os resultados da necrópsia para melhoria do tratamento da insuficiência cardíaca por meio do transplante cardíaco.

An evaluation of efforts by nuclear power plants to use ASTM D3803-89

International Nuclear Information System (INIS)

Freeman, W.P.

1995-01-01

The number of nuclear power plants are now using ASTM D3803-89, open-quotes Standard Test Method for Nuclear-Grade Activated Carbonclose quotes for routine surveillance testing of adsorbents. In order to judge the impact of this change, we have gathered radioiodine removal test results from our data base on a system-by-system basis (i.e. control room, technical support center, and spent fuel pool) and compared test results obtained for the same kind of systems using the new and older test methods. Included in this comparison are systems with and without humidity control. Results are discussed from the standpoint of what to expect if a change to testing using ASTM D3803-89 is contemplated, especially regarding test results in light existing acceptance criteria. Additionally, the results are discussed from the standpoint of the sensitivity of the ASTM test method to detect when the performance of the carbon in air cleaning systems has been compromised (compared to the older methods). Finally, we offer some suggestions for how other plants might upgrade their carbon testing to incorporate testing to ASTM D3803-89

An evaluation of efforts by nuclear power plants to use ASTM D3803-89

Energy Technology Data Exchange (ETDEWEB)

Freeman, W.P.

1995-02-01

The number of nuclear power plants are now using ASTM D3803-89, {open_quotes}Standard Test Method for Nuclear-Grade Activated Carbon{close_quotes} for routine surveillance testing of adsorbents. In order to judge the impact of this change, we have gathered radioiodine removal test results from our data base on a system-by-system basis (i.e. control room, technical support center, and spent fuel pool) and compared test results obtained for the same kind of systems using the new and older test methods. Included in this comparison are systems with and without humidity control. Results are discussed from the standpoint of what to expect if a change to testing using ASTM D3803-89 is contemplated, especially regarding test results in light existing acceptance criteria. Additionally, the results are discussed from the standpoint of the sensitivity of the ASTM test method to detect when the performance of the carbon in air cleaning systems has been compromised (compared to the older methods). Finally, we offer some suggestions for how other plants might upgrade their carbon testing to incorporate testing to ASTM D3803-89.

DeltaF508 heterozygosity in cystic fibrosis and susceptibility to asthma

DEFF Research Database (Denmark)

Dahl, Morten; Tybjaerg-Hansen, A; Lange, P

1998-01-01

Cystic fibrosis is a recessive disorder mainly characterised by lung disease. We tested the hypothesis that individuals heterozygous for the common cystic fibrosis deltaF508 mutation are at risk of obstructive pulmonary disease.......Cystic fibrosis is a recessive disorder mainly characterised by lung disease. We tested the hypothesis that individuals heterozygous for the common cystic fibrosis deltaF508 mutation are at risk of obstructive pulmonary disease....

ENHANCED HYBRID PSO – ACO ALGORITHM FOR GRID SCHEDULING

Directory of Open Access Journals (Sweden)

P. Mathiyalagan

2010-07-01

Full Text Available Grid computing is a high performance computing environment to solve larger scale computational demands. Grid computing contains resource management, task scheduling, security problems, information management and so on. Task scheduling is a fundamental issue in achieving high performance in grid computing systems. A computational GRID is typically heterogeneous in the sense that it combines clusters of varying sizes, and different clusters typically contains processing elements with different level of performance. In this, heuristic approaches based on particle swarm optimization and ant colony optimization algorithms are adopted for solving task scheduling problems in grid environment. Particle Swarm Optimization (PSO is one of the latest evolutionary optimization techniques by nature. It has the better ability of global searching and has been successfully applied to many areas such as, neural network training etc. Due to the linear decreasing of inertia weight in PSO the convergence rate becomes faster, which leads to the minimal makespan time when used for scheduling. To make the convergence rate faster, the PSO algorithm is improved by modifying the inertia parameter, such that it produces better performance and gives an optimized result. The ACO algorithm is improved by modifying the pheromone updating rule. ACO algorithm is hybridized with PSO algorithm for efficient result and better convergence in PSO algorithm.

Free electron laser on the ACO storage ring

International Nuclear Information System (INIS)

Elleaume, P.

1984-06-01

This dissertation presents the design and characteristics of a Free Electron Laser built on the electron storage ring ACO at Orsay. The weak optical gain available (approximately 0.1% per pass) necessitated the use of an optical klystron instead of an undulator and the use of mirror with extremely high reflectivity. The laser characteristics: spectra, micro and macro-temporal structures, transverse structure and power are presented. They are in very good agreement with a classical theory based on the Lorentz force and Maxwell equations [fr

Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia

Science.gov (United States)

Olszewska-Pazdrak, Barbara; Carney, Darrell H.

2015-01-01

Revascularization of chronic wounds and ischemic tissue is attenuated by endothelial dysfunction and the inability of angiogenic factors to stimulate angiogenesis. We recently showed that TP508, a nonproteolytic thrombin peptide, increases perfusion and NO-dependent vasodilation in hearts with chronic ischemia and stimulates NO production by endothelial cells. In this study, we investigated systemic in vivo effects of TP508 on VEGF-stimulated angiogenesis in vitro using aortic explants in normoxic and hypoxic conditions. Mice were injected with saline or TP508 and 24h later aortas were removed and cultured to quantify endothelial sprouting. TP508 injection increased endothelial sprouting and potentiated the in vitro response to VEGF. Exposure of control explants to hypoxia inhibited basal and VEGF-stimulated endothelial cell sprouting. This effect of hypoxia was significantly prevented by TP508 injection. Thus, TP508 systemic administration increases responsiveness of aortic endothelial cells to VEGF and diminishes the effect of chronic hypoxia on endothelial cell sprouting. Studies using human endothelial cells in culture suggest that protective effects of TP508 during hypoxia may involve stimulation of endothelial cell NO production. These data suggest potential clinical benefit of using a combination of systemic TP508 and local VEGF as a therapy for revascularization of ischemic tissue. PMID:23594718

Deriving allowable properties of lumber : a practical guide for interpretation of ASTM standards

Science.gov (United States)

Alan Bendtsen; William L. Galligan

1978-01-01

The ASTM standards for establishing clear wood mechanical properties and for deriving structural grades and related allowable properties for visually graded lumber can be confusing and difficult for the uninitiated to interpret. This report provides a practical guide to using these standards for individuals not familiar with their application. Sample stress...

Corrosion Behavior of SA508 Coupled with and without Magnetite in Chemical Cleaning Environments

International Nuclear Information System (INIS)

Son, Yeong-Ho; Jeon, Soon-Hyeok; Song, Geun Dong; Hur, Do Haeng; Lee, Jong-Hyeon

2017-01-01

To mitigate these problems, chemical cleaning process has been widely used. However, the chemical cleaning solution can affect the corrosion of SG structural materials as well as the magnetite dissolution. During the chemical cleaning process, the galvanic corrosion between SG materials and magnetite is also anticipated because they are in electrical connection. However, the corrosion measurement or monitoring for the materials has been performed without consideration of galvanic effect coupled with magnetite during the chemical cleaning process. In this study, the effect of temperature and EDTA concentration on the corrosion behavior of SA508 tubesheet material with and without magnetite was studied in chemical cleaning solutions. The galvanic corrosion behavior between SA508 and magnetite is predicted by using the mixed potential theory and its effect on the corrosion rate of SA508 is also discussed. By newly designed immersion test, it was confirmed that the extent of galvanic corrosion effect between SA508 and magnetite increased with increasing temperature and EDTA concentration. The galvanic corrosion behavior of SA508 coupled with magnetite in chemical cleaning environments was predicted by the mixed potential theory and verified by ZRA and LP technique. Galvanic coupling increased the corrosion rate of SA508 due to the shift in its potential to the anodic direction. Therefore, the galvanic corrosion effect between SA508 and magnetite should be considered when the corrosion measurement is performed during the chemical cleaning process in steam generators.

Side chain and backbone contributions of Phe508 to CFTR folding

Energy Technology Data Exchange (ETDEWEB)

Thibodeau, Patrick H.; Brautigam, Chad A.; Machius, Mischa; Thomas, Philip J. (U. of Texas-SMED)

2010-12-07

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an integral membrane protein, cause cystic fibrosis (CF). The most common CF-causing mutant, deletion of Phe508, fails to properly fold. To elucidate the role Phe508 plays in the folding of CFTR, missense mutations at this position were generated. Only one missense mutation had a pronounced effect on the stability and folding of the isolated domain in vitro. In contrast, many substitutions, including those of charged and bulky residues, disrupted folding of full-length CFTR in cells. Structures of two mutant nucleotide-binding domains (NBDs) reveal only local alterations of the surface near position 508. These results suggest that the peptide backbone plays a role in the proper folding of the domain, whereas the side chain plays a role in defining a surface of NBD1 that potentially interacts with other domains during the maturation of intact CFTR.

Towards the Fourier limit on the super-ACO Storage Ring FEL

International Nuclear Information System (INIS)

Couprie, M.E.; De Ninno, G.; Moneron, G.; Nutarelli, D.; Hirsch, M.; Garzella, D.; Renault, E.; Roux, R.; Thomas, C.

2001-01-01

Systematic studies on the Free Electron Laser (FEL) line and micropulse have been performed on the Super-ACO storage ring FEL with a monochromator and a double-sweep streak camera under various conditions of operation (detuning, 'CW' and Q-switched mode). From these data, it appears that the FEL is usually operated very close to the Fourier limit

Towards the Fourier limit on the super-ACO Storage Ring FEL

CERN Document Server

Couprie, Marie Emmanuelle; Garzella, D; Hirsch, M; Moneron, G; Nutarelli, D; Renault, E; Roux, R; Thomas, C

2001-01-01

Systematic studies on the Free Electron Laser (FEL) line and micropulse have been performed on the Super-ACO storage ring FEL with a monochromator and a double-sweep streak camera under various conditions of operation (detuning, 'CW' and Q-switched mode). From these data, it appears that the FEL is usually operated very close to the Fourier limit.

17 CFR 249.508 - Form 8-M, consent to service of process by a corporation which is a nonresident broker-dealer.

Science.gov (United States)

2010-04-01

... to service of process by a corporation which is a nonresident broker-dealer. This form shall be filed... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form 8-M, consent to service of process by a corporation which is a nonresident broker-dealer. 249.508 Section 249.508 Commodity...

The mechanism of uranium adsorption on Resin 508 and isoelectric point of the resin

International Nuclear Information System (INIS)

Han Qingping; Lu Weichang; Su Huijuan; Hu Jinbo; Zhang Liqin; Chen Banglin

1990-01-01

The adsorption process of uranium by Resin 508 at the solid-liquid interface was investigated and the mechanism of uranium adsorption including adsorption dynamics, adsorption thermodynamics and isoelectric point of resin was studied. The results are as follows: The maximum of uranium adsorption is attained at pH5-7; Uranium adsorption isotherm by Resin 508 in experimental conditions agrees with Langmuir's adsorption isotherm, the maximum of uranium adsorbed (Vm) is 716 mg U/g-dried resin; The adsorption of uranium by Resin 508 is an endothermic reaction and ΔH = 16.87 kJ/mol; The exchange-adsorption rate is mainly controlled by liquid film diffusion; The isoelectric points of Resin 508 before and after uranium adsorption are found to be pH7.5 and pH5.7 respectively. It is a specific adsorption for uranium

An Evaluation of a Proposed Revision of the ASTM D 1990 Grouping Procedure

Science.gov (United States)

Steve P Verrill; James W. Evans; David E. Kretschmann; Cherilyn A. Hatfield

2013-01-01

Lum, Taylor, and Zidek have proposed a revised procedure for wood species grouping in ASTM standard D 1990. We applaud the authors’ recognition of the importance of considering a strength distribution’s variability as well as its fifth percentile. However, we have concerns about their proposed method of incorporating this information into a standard. We detail these...

A cena constituinte da psicose maníaco-depressiva no Brasil The emergence of manic depressive psychosis as a diagnosis in Brazil

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Joel Birman

2010-12-01

Full Text Available A intenção deste ensaio é esboçar a leitura da psicose maníaco-depressiva no Brasil, no começo do século XX. Destaca a transformação teórica ocorrida na psiquiatria brasileira, que se deslocou da tradição francesa para a alemã. Sublinha o modo como a problemática da histeria foi substituída pela da psicose maníaco-depressiva nesse contexto histórico.This essay examines the early twentieth-century interpretation of manic depressive psychosis in Brazil, during a moment when Brazilian psychiatry witnessed a theoretical shift from the French to German traditions. It calls special attention to how the problem of hysteria was replaced by manic depressive psychosis within this historical context.

Eight reasons payer interoperability and data sharing are essential in ACOs. Interoperability standards could be a prerequisite to measuring care.

Science.gov (United States)

Mookencherry, Shefali

2012-01-01

It makes strategic and business sense for payers and providers to collaborate on how to take substantial cost out of the healthcare delivery system. Acting independently, neither medical groups, hospitals nor health plans have the optimal mix of resources and incentives to significantly reduce costs. Payers have core assets such as marketing, claims data, claims processing, reimbursement systems and capital. It would be cost prohibitive for all but the largest providers to develop these capabilities in order to compete directly with insurers. Likewise, medical groups and hospitals are positioned to foster financial interdependence among providers and coordinate the continuum of patient illnesses and care settings. Payers and providers should commit to reasonable clinical and cost goals, and share resources to minimize expenses and financial risks. It is in the interest of payers to work closely with providers on risk-management strategies because insurers need synergy with ACOs to remain cost competitive. It is in the interest of ACOs to work collaboratively with payers early on to develop reasonable and effective performance benchmarks. Hence, it is essential to have payer interoperability and data sharing integrated in an ACO model.

A physically-based constitutive model for SA508-III steel: Modeling and experimental verification

International Nuclear Information System (INIS)

Dong, Dingqian; Chen, Fei; Cui, Zhenshan

2015-01-01

Due to its good toughness and high weldability, SA508-III steel has been widely used in the components manufacturing of reactor pressure vessels (RPV) and steam generators (SG). In this study, the hot deformation behaviors of SA508-III steel are investigated by isothermal hot compression tests with forming temperature of (950–1250)°C and strain rate of (0.001–0.1)s −1 , and the corresponding flow stress curves are obtained. According to the experimental results, quantitative analysis of work hardening and dynamic softening behaviors is presented. The critical stress and critical strain for initiation of dynamic recrystallization are calculated by setting the second derivative of the third order polynomial. Based on the classical stress–dislocation relation and the kinetics of dynamic recrystallization, a two-stage constitutive model is developed to predict the flow stress of SA508-III steel. Comparisons between the predicted and measured flow stress indicate that the established physically-based constitutive model can accurately characterize the hot deformations for the steel. Furthermore, a successful numerical simulation of the industrial upsetting process is carried out by implementing the developed constitutive model into a commercial software, which evidences that the physically-based constitutive model is practical and promising to promote industrial forging process for nuclear components

A physically-based constitutive model for SA508-III steel: Modeling and experimental verification

Energy Technology Data Exchange (ETDEWEB)

Dong, Dingqian [National Die & Mold CAD Engineering Research Center, Shanghai Jiao Tong University, 1954 Huashan Rd., Shanghai 200030 (China); Chen, Fei, E-mail: feechn@gmail.com [National Die & Mold CAD Engineering Research Center, Shanghai Jiao Tong University, 1954 Huashan Rd., Shanghai 200030 (China); Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham, Nottingham NG7 2RD (United Kingdom); Cui, Zhenshan, E-mail: cuizs@sjtu.edu.cn [National Die & Mold CAD Engineering Research Center, Shanghai Jiao Tong University, 1954 Huashan Rd., Shanghai 200030 (China)

2015-05-14

Due to its good toughness and high weldability, SA508-III steel has been widely used in the components manufacturing of reactor pressure vessels (RPV) and steam generators (SG). In this study, the hot deformation behaviors of SA508-III steel are investigated by isothermal hot compression tests with forming temperature of (950–1250)°C and strain rate of (0.001–0.1)s{sup −1}, and the corresponding flow stress curves are obtained. According to the experimental results, quantitative analysis of work hardening and dynamic softening behaviors is presented. The critical stress and critical strain for initiation of dynamic recrystallization are calculated by setting the second derivative of the third order polynomial. Based on the classical stress–dislocation relation and the kinetics of dynamic recrystallization, a two-stage constitutive model is developed to predict the flow stress of SA508-III steel. Comparisons between the predicted and measured flow stress indicate that the established physically-based constitutive model can accurately characterize the hot deformations for the steel. Furthermore, a successful numerical simulation of the industrial upsetting process is carried out by implementing the developed constitutive model into a commercial software, which evidences that the physically-based constitutive model is practical and promising to promote industrial forging process for nuclear components.

Diminished self-chaperoning activity of the DeltaF508 mutant of CFTR results in protein misfolding.

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Adrian W R Serohijos

2008-02-01

Full Text Available The absence of a functional ATP Binding Cassette (ABC protein called the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR from apical membranes of epithelial cells is responsible for cystic fibrosis (CF. Over 90% of CF patients carry at least one mutant allele with deletion of phenylalanine at position 508 located in the N-terminal nucleotide binding domain (NBD1. Biochemical and cell biological studies show that the DeltaF508 mutant exhibits inefficient biosynthetic maturation and susceptibility to degradation probably due to misfolding of NBD1 and the resultant misassembly of other domains. However, little is known about the direct effect of the Phe508 deletion on the NBD1 folding, which is essential for rational design strategies of cystic fibrosis treatment. Here we show that the deletion of Phe508 alters the folding dynamics and kinetics of NBD1, thus possibly affecting the assembly of the complete CFTR. Using molecular dynamics simulations, we find that meta-stable intermediate states appearing on wild type and mutant folding pathways are populated differently and that their kinetic accessibilities are distinct. The structural basis of the increased misfolding propensity of the DeltaF508 NBD1 mutant is the perturbation of interactions in residue pairs Q493/P574 and F575/F578 found in loop S7-H6. As a proof-of-principle that the S7-H6 loop conformation can modulate the folding kinetics of NBD1, we virtually design rescue mutations in the identified critical interactions to force the S7-H6 loop into the wild type conformation. Two redesigned NBD1-DeltaF508 variants exhibited significantly higher folding probabilities than the original NBD1-DeltaF508, thereby partially rescuing folding ability of the NBD1-DeltaF508 mutant. We propose that these observed defects in folding kinetics of mutant NBD1 may also be modulated by structures separate from the 508 site. The identified structural determinants of increased misfolding propensity of

Application of MCDM based hybrid optimization tool during turning of ASTM A588

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Himadri Majumder

2017-07-01

Full Text Available Multi-criteria decision making approach is one of the most troublesome tools for solving the tangled optimization problems in the machining area due to its capability of solving the complex optimization problems in the production process. Turning is widely used in the manufacturing processes as it offers enormous advantages like good quality product, customer satisfaction, economical and relatively easy to apply. A contemporary approach, MOORA coupled with PCA, was used to ascertain an optimal combination of input parameters (spindle speed, depth of cut and feed rate for the given output parameters (power consumption, average surface roughness and frequency of tool vibration using L27 orthogonal array for turning on ASTM A588 mild steel. Comparison between MOORA-PCA and TOPSIS-PCA shows the effectiveness of MOORA over TOPSIS method. The optimum parameter combination for multi-performance characteristics has been established for ASTM A588 mild steel are spindle speed 160 rpm, depth of cut 0.1 mm and feed rate 0.08 mm/rev. Therefore, this study focuses on the application of the hybrid MCDM approach as a vital selection making tool to deal with multi objective optimization problems.

Certeza diagnóstica en la mortalidad de una población de pacientes con trasplante cardíaco

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Marcos Amuchástegui

2008-01-01

Full Text Available RESUMENIntroducciónA pesar de que la morbimortalidad en el trasplante cardíaco ha sido motivo de extensoanálisis, la mayoría de los estudios y registros de mortalidad en pacientes trasplantados sebasan sobre datos clínicos. En la bibliografía existen comunicaciones aisladas de autopsiasen pacientes con trasplante cardíaco.ObjetivoDeterminar la importancia de la realización de estudios anatomopatológicos para el diagnósticode causa de muerte en un programa de trasplante cardíaco.Material y métodosSe incluyeron todos los pacientes con trasplante cardíaco fallecidos entre enero 1990 y enero2005. El diagnóstico definitivo de la causa de muerte fue corroborado por autopsia obiopsia de órgano sólido. Las causas de muerte evaluadas fueron falla precoz del injerto,rechazo celular, infección, enfermedad vascular del injerto, neoplasia y otros.ResultadosDurante el período en estudio 73 pacientes fueron sometidos a trasplante cardíaco; de ellos,fallecieron 31. Se obtuvieron 12 autopsias y 7 biopsias de órgano sólido que certificaron lacausa de muerte (61%. La causa de muerte más frecuente fue el rechazo celular mayor degrado III. En el 12,9%, la anatomía patológica difirió de la sospecha clínica de la causa demuerte.ConclusiónLa información clinicopatológica derivada de estudios post mortem es un indicador de nuestrarealidad asistencial y se constituye en un pilar fundamental para el conocimiento y elmanejo futuro de los pacientes trasplantados, por lo que consideramos que la realización deautopsias en estos pacientes es de vital importancia.REV ARGENT CARDIOL 2008;76:292-294.

A new method to determine J0-integral values (ASTM E 813) without any auxiliary equipment

International Nuclear Information System (INIS)

Ullrich, G.; Krompholz, K.

1987-01-01

In this contribution the path independent J-integral according to J.R. Rice, respective J.D. Landes and J.A. Begley due to ASTME 813 is calculated by the product J pl = d v J el for 3 point bend type specimen. Here d v is the load point displacement up to the point of the onset of stable crack growth V, which is taken from the load versus load point displacement diagram and J el a value which is equivalent to K 2 /E, where K is the stress intensity factor (ASTME 399) and E is Young's modulus. The advantage of the new procedure is the simplicity of the test arrangement and of the evaluation with the determination of initiation point V without computer or other auxiliary equipment. (orig.) [de

Acute Care of At-Risk Newborns (ACoRN: quantitative and qualitative educational evaluation of the program in a region of China

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Singhal Nalini

2012-06-01

Full Text Available Abstract Background The Acute Care of at-Risk Newborns (ACoRN program was developed in Canada for trained health care providers for the identification and management of newborns who are at-risk and/or become unwell in the first few hours or days after birth. The ACoRN process follows an 8-step framework that enables the evaluation and management of babies irrespective of the experience or expertise of the caregiving individual or team. This study assesses the applicability of the program to Chinese pediatric practitioners. Methods Course content and educational materials were translated from English into Chinese by bilingual neonatal practitioners. Confidence and knowledge questionnaires were developed and reviewed for face and content validity by a team of ACoRN instructors. Bilingual Chinese instructors were trained at the tertiary perinatal centre in Hangzhou Zhejiang to deliver the course at 15 level II county hospitals. Participants completed pre- and post-course confidence and knowledge questionnaires and provided feedback through post-course focus groups. Results 216 physicians and nurses were trained. Confidence and knowledge relating to neonatal stabilization improved significantly following the courses. Participants rated course utility and function between 4.2 and 4.6/5 on all items. Pre/post measures of confidence were significantly correlated with post course knowledge. Focus group data supported the perceived value of the program and recommended course adjustments to include pre-course reading, and increased content related to simulation, communication skills, and management of respiratory illness and jaundice. Conclusions ACoRN, a Canadian educational program, appears to be well received by Chinese health care providers and results in improved knowledge and confidence. International program adaptation for use by health care professionals requires structured and systematic evaluation to ensure that the program meets the needs of

ASTM International Workshop on Standards & Measurements for Tissue Engineering Scaffolds

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Simon, Carl G.; Yaszemski, Michael J.; Ratcliffe, Anthony; Tomlins, Paul; Luginbuehl, Reto; Tesk, John A.

2016-01-01

The “Workshop on Standards & Measurements for Tissue Engineering Scaffolds” was held on May 21, 2013 in Indianapolis, IN and was sponsored by the ASTM International (ASTM). The purpose of the workshop was to identify the highest priority items for future standards work for scaffolds used in the development and manufacture of tissue engineered medical products (TEMPs). Eighteen speakers and 78 attendees met to assess current scaffold standards and to prioritize needs for future standards. A key finding was that the ASTM TEMPs subcommittees (F04.41-46) have many active “guide” documents for educational purposes, but that few standard “test methods” or “practices” have been published. Overwhelmingly, the most clearly identified need was standards for measuring the structure of scaffolds, followed by standards for biological characterization, including in vitro testing, animal models and cell-material interactions. The third most pressing need was to develop standards for assessing the mechanical properties of scaffolds. Additional needs included standards for assessing scaffold degradation, clinical outcomes with scaffolds, effects of sterilization on scaffolds, scaffold composition and drug release from scaffolds. Discussions also highlighted the need for additional scaffold reference materials and the need to use them for measurement traceability. Finally, dialogue emphasized the needs to promote the use of standards in scaffold fabrication, characterization, and commercialization and to assess the use and impact of standards in the TEMPs community. Many scaffold standard needs have been identified and focus should now turn to generating these standards to support the use of scaffolds in TEMPs. PMID:25220952

The role of the American Society for Testing and Materials (ASTM) in providing standards to support reliability technology for nuclear power plants

International Nuclear Information System (INIS)

Steele, L.E.

1978-01-01

ASTM is an international society for managing the development of standards on characteristics and performance of materials, products, systems and services and the promotion of related knowledge. This paper provides on overview of ASTM, emphasizing its contribution to nuclear systems reliability. In so doing, the author, from his perspective as chairman of ASTM committee E 10 on ''Nuclear Applications and the Measurement of Radiation Effects and the Committee on Standards'', illustrates ASTM contributions to the understanding and control of radiation embrittlement of light-water reactor pressure vessels. Four major related taks are summarized and pertinent standards identified. These include: (1) surveillance practice (5 standards), (2) neutron dosimetry (8 standards), (3) specification for steels for nuclear service (7 standards) and (4) basic guidelines for thermal annealing to correct radiation embrittlement (1 standard). This illustration, a specific accomplishment using ASTM standards, is cited within the context of the broader nuclear-related activities of ASTM. (author)

Prevalência da mutação ΔF508 no gene cystic fibrosis transmembrane conductance regulator em pacientes com fibrose cística em um centro de referência no Brasil Prevalence of ΔF508 mutation in the cystic fibrosis transmembrane conductance regulator gene among cystic fibrosis patients from a Brazilian referral center

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Andréia Marisa Bieger

2012-12-01

Full Text Available OBJETIVO: Verificar a presença da mutação ΔF508 no gene cystic fibrosis transmembrane conductance regulator na população de pacientes com fibrose cística, diagnosticados pelo teste de sódio e cloro no suor, em acompanhamento no Ambulatório de Pneumologia Pediátrica da Universidade Estadual de Campinas, centro de referência no tratamento da fibrose cística. MÉTODOS: Foram analisadas 167 amostras de DNA de pacientes com fibrose cística. O genótipo dos pacientes foi determinado pela técnica de reação da polimerase e realizado cálculo para a frequência dos alelos e genótipos da mutação ΔF508. RESULTADOS: A frequência genotípica encontrada foi, respectivamente, para os genótipos -/-, ΔF508/- e ΔF508/ΔF508: 43,7% (73 pacientes, 32,9% (55 pacientes e 23,4% (39 pacientes. Do total de 334 alelos analisados, foi observada a frequência de 201 (60,18% alelos para a ausência da mutação ΔF508 e de 133 (39,82% para a presença da mutação ΔF508. O cálculo do equilíbrio de Hardy-Weinberg foi realizado, e obtivemos o valor de qui-quadrado = 16,34 (p OBJECTIVE: To verify the presence of ΔF508 mutation in the cystic fibrosis transmembrane conductance regulator gene among patients with cystic fibrosis diagnosed by the sweat test for sodium and chlorine and followed at the Pediatric Pneumology Outpatient Clinic of Universidade Estadual de Campinas, Brazil, a referral center for the treatment of cystic fibrosis. METHODS: The study analyzed 167 DNA samples from cystic fibrosis patients. Patients' genotype was determined by polymerase chain reaction, and allele and genotype frequencies of ΔF508 mutation were calculated. RESULTS: The genotype frequencies found for -/-, ΔF508/-, and ΔF508/ΔF508 genotypes were respectively: 43.7% (73 patients, 32.9% (55 patients, and 23.4% (39 patients. Of the 334 alleles analyzed, we observed a frequency of 201 (60.18% alleles for the absence of ΔF508 mutation and of 133 (39.82% for the

PROPOSED ASTM METHOD FOR THE DETERMINATION OF ASBESTOS IN AIR BY TEM AND INFORMATION ON INTERFERING FIBERS

Science.gov (United States)

The draft of the ASTM Test Method for air entitled: "Airborne Asbestos Concentration in Ambient and Indoor Atmospheres as Determined by Transmission Electron Microscopy Direct Transfer (TEM)" (ASTM Z7077Z) is an adaptation of the International Standard, ISO 10312. It is currently...

Domainwise Web Page Optimization Based On Clustered Query Sessions Using Hybrid Of Trust And ACO For Effective Information Retrieval

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Dr. Suruchi Chawla

2015-08-01

Full Text Available Abstract In this paper hybrid of Ant Colony OptimizationACO and trust has been used for domainwise web page optimization in clustered query sessions for effective Information retrieval. The trust of the web page identifies its degree of relevance in satisfying specific information need of the user. The trusted web pages when optimized using pheromone updates in ACO will identify the trusted colonies of web pages which will be relevant to users information need in a given domain. Hence in this paper the hybrid of Trust and ACO has been used on clustered query sessions for identifying more and more relevant number of documents in a given domain in order to better satisfy the information need of the user. Experiment was conducted on the data set of web query sessions to test the effectiveness of the proposed approach in selected three domains Academics Entertainment and Sports and the results confirm the improvement in the precision of search results.

JST Thesaurus Headwords and Synonyms: ASTM [MeCab user dictionary for science technology term[Archive

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Full Text Available MeCab user dictionary for science technology term ASTM 名詞 一般 * * * * 米国材料試験協会 ベイコクザ...イリョウシケンキョウカイ ベイコクザイリョーシケンキョーカイ Thesaurus2015 200906091611619997 C IA02 UNKNOWN_1 ASTM

Sedação com sufentanil e clonidina em pacientes submetidos a cateterismo cardíaco Sedación con sufentanil y clonidina en pacientes sometidos a cateterismo cardíaco Sedation with sufentanil and clonidine in patients undergoing heart catheterization

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Anita Perpetua Carvalho Rocha

2011-03-01

Full Text Available FUNDAMENTO: A sedação para a realização de cateterismo cardíaco tem sido alvo de preocupação. Benzodiazepínicos, agonistas alfa-2 adrenérgicos e opioides são utilizados para esse fim, entretanto, cada um destes medicamentos possui vantagens e desvantagens. OBJETIVO: Avaliar a eficácia do sufentanil e da clonidina como sedativos em pacientes submetidos a cateterismo cardíaco, observando o impacto dos mesmos sobre os parâmetros hemodinâmicos e respiratórios, a presença de efeitos colaterais, além da satisfação do paciente e do hemodinamicista com o exame. MÉTODOS: Trata-se de um ensaio clínico prospectivo, duplo-cego, randomizado e controlado, que envolveu 60 pacientes que receberam 0,1 µg/kg de sufentanil ou 0,5 µg/kg de clonidina antes da realização do cateterismo cardíaco. O escore de sedação segundo a escala de Ramsay, a necessidade de utilização de midazolam, os efeitos colaterais, os parâmetros hemodinâmicos e respiratórios foram registrados, sendo os dados analisados em 06 diferentes momentos. RESULTADOS: O comportamento da pressão arterial, da frequência cardíaca e da frequência respiratória foi semelhante nos dois grupos, entretanto, no momento 2, os pacientes do grupo sufentanil (Grupo S apresentaram menor escore de sedação segundo a escala de Ramsay, e a saturação periférica da oxihemoglobina foi menor que o grupo clonidina (Grupo C no momento 6. Os pacientes do Grupo S apresentaram maior incidência de náusea e vômito pós-operatório que os pacientes do Grupo C. A satisfação dos pacientes foi maior no grupo clonidina. Os hemodinamicistas mostraram-se satisfeitos nos dois grupos. CONCLUSÃO: O sufentanil e a clonidina foram efetivos como sedativos em pacientes submetidos a cateterismo cardíaco.FUNDAMENTO: La sedación para la realización de cateterismo cardíaco ha sido blanco de preocupación. Benzodiazepínicos, agonistas alfa-2 adrenérgicos y opioides son utilizados para ese fin

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.

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De Stefano, Daniela; Villella, Valeria R; Esposito, Speranza; Tosco, Antonella; Sepe, Angela; De Gregorio, Fabiola; Salvadori, Laura; Grassia, Rosa; Leone, Carlo A; De Rosa, Giuseppe; Maiuri, Maria C; Pettoello-Mantovani, Massimo; Guido, Stefano; Bossi, Anna; Zolin, Anna; Venerando, Andrea; Pinna, Lorenzo A; Mehta, Anil; Bona, Gianni; Kroemer, Guido; Maiuri, Luigi; Raia, Valeria

2014-01-01

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in Cftr(F508del) homozygous mice. Cysteamine, the reduced form of cystamine, is an FDA-approved drug. Here, we report that oral treatment with cysteamine greatly reduces the mortality rate and improves the phenotype of newborn mice bearing the F508del-CFTR mutation. Cysteamine was also able to increase the plasma membrane expression of the F508del-CFTR protein in nasal epithelial cells from F508del homozygous CF patients, and these effects persisted for 24 h after cysteamine withdrawal. Importantly, this cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. In a pilot clinical trial involving 10 F508del-CFTR homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells in vivo, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of TNF/TNF-alpha (tumor necrosis factor) and CXCL8 (chemokine [C-X-C motif] ligand 8) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation.

Highly preferential association of NonF508del CF mutations with the M470 allele.

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Ciminelli, B M; Bonizzato, A; Bombieri, C; Pompei, F; Gabaldo, M; Ciccacci, C; Begnini, A; Holubova, A; Zorzi, P; Piskackova, T; Macek, M; Castellani, C; Modiano, G; Pignatti, P F

2007-01-01

On the basis of previous findings on random individuals, we hypothesized a preferential association of CF causing mutations with the M allele of the M470V polymorphic site of the CFTR gene. We have determined the M/V-CF mutation haplotype in a series of 201 North East Italian and 73 Czech CF patients who were not F508del homozygotes, as F508del was already known to be fully associated with the M allele. Out of 358 not F508del CF genes, 84 carried the V allele and 274 the less common M allele. In the N-E Italian population, MM subjects have a risk of carrying a CF causing mutation 6.9x greater than VV subjects when F508del is excluded and 15.4x when F508del is included. In the Czech population a similar, although less pronounced, association is observed. Besides the possible biological significance of this association, the possibility of exploiting it for a pilot screening program has been explored in a local North East Italian population for which CF patients were characterized for their CF mutation. General M470V genotyping followed by common CF mutation screening limited to couples in which each partner carries at least one M allele would need testing only 39% of the couples, which contribute 89% of the total risk, with a cost benefit.

MÉTODOS PARA CARACTERIZAR COMBUSTIBLES LÍQUIDOS Y GASEOSOS OBTENIDOS DE LLANTAS EN DESUSO A TRAVÉS DE LAS NORMAS ASTM.

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JAIME ALEJANDRO OSPINA

2011-12-01

Full Text Available Este artículo muestra la importancia de la caracterización de la energía de combustibles líquidos y gaseosos obtenidos del conocido tratamiento térmico de pirolisis a través de un microondas. La caracterización de estos combustibles tomará en cuenta los estándares técnicos tales como ASTM D3452 – 93 para la cromatografía de gases (GC, ASTM D2549 para cromatografía de gas/ espectrometría de masa (GC/MS y ASTM D6370 -99 para termogravimetría en el análisis de la composición de llantas.También muestra que estos combustibles y gases de pirolisis tiene una alta valor calorífico de 42 MJ / Kg y un contenido de azufre entre 0.8 y 1.65 Wt%, dependiendo en el tipo de llanta y las condiciones del proceso.

Bioimpedância transtorácica comparada à ressonância magnética na avaliação do débito cardíaco

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Humberto Villacorta Junior

Full Text Available FUNDAMENTO: A ressonância magnética cardíaca é considerada o método padrão-ouro para o cálculo de volumes cardíacos. A bioimpedância transtorácica cardíaca avalia o débito cardíaco. Não há trabalhos que validem essa medida comparada à ressonância. OBJETIVO: Avaliar o desempenho da bioimpedância transtorácica cardíaca no cálculo do débito cardíaco, índice cardíaco e volume sistólico, utilizando a ressonância como padrão-ouro. MÉTODOS: Avaliados 31 pacientes, com média de idade de 56,7 ± 18 anos, sendo 18 (58% do sexo masculino. Foram excluídos os pacientes cuja indicação para a ressonância magnética cardíaca incluía avaliação sob estresse farmacológico. A correlação entre os métodos foi avaliada pelo coeficiente de Pearson, e a dispersão das diferenças absolutas em relação à média foi demonstrada pelo método de Bland-Altman. A concordância entre os métodos foi realizada pelo coeficiente de correlação intraclasses. RESULTADOS: A média do débito cardíaco pela bioimpedância transtorácica cardíaca e pela ressonância foi, respectivamente, 5,16 ± 0,9 e 5,13 ± 0,9 L/min. Observou-se boa correlação entre os métodos para o débito cardíaco (r = 0,79; p = 0,0001, índice cardíaco (r = 0,74; p = 0,0001 e volume sistólico (r = 0,88; p = 0,0001. A avaliação pelo gráfico de Bland-Altman mostrou pequena dispersão das diferenças em relação à média, com baixa amplitude dos intervalos de concordância. Houve boa concordância entre os dois métodos quando avaliados pelo coeficiente de correlação intraclasses, com coeficientes para débito cardíaco, índice cardíaco e volume sistólico de 0,78, 0,73 e 0,88, respectivamente (p < 0,0001 para todas as comparações. CONCLUSÃO: A bioimpedância transtorácica cardíaca mostrou-se acurada no cálculo do débito cardíaco quando comparada à ressonância magnética cardíaca.

Omalizumab (anti-IgE) therapy in the asthma-COPD overlap syndrome (ACOS) and its effects on circulating cytokine levels.

Science.gov (United States)

Yalcin, Arzu Didem; Celik, Betul; Yalcin, Ata Nevzat

2016-06-01

The term "asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome" (ACOS) has been applied to the condition, in which a person has clinical features of both asthma and COPD. The patients (N = 10) were presented to our clinic with low lung function, limited reversibility of airway obstruction, hyperinflation, abnormal body composition, dyspnea and episodic wheezing. Based on the clinical and laboratory findings, the patients were diagnosed with ACOS. Patients' serum IL-2 (sIL-2), sIL-4 sIL-6, sIL-10, sIL-17, sTNF-α and sIFN-γ levels were investigated as an apoptotic marker and a marker for inflammation. Having undergone omalizumab treatment and a long-term (12 months) later, patients had a decreased IgE, fractional exhaled nitric oxide concentrations (FENO), eosinophil, neutrophils, macrophages, eosinophil cationic peptide (ECP) and sIL-4 levels. To our knowledge, this is the first documentation of omalizumab use in ACOS. We demonstrated decreased IL-4, allergic pulmonary symptoms (dyspnea, wheezing, bronchial hyper responsiveness) and migraine attacks in the patients.

Estimación del gasto cardíaco: Utilidad en la práctica clínica. Monitorización disponible invasiva y no invasiva

OpenAIRE

García, X.; Mateu, L.; Maynar, J.; Mercadal, J.; Ochagavía, A.; Ferrandiz, A.

2011-01-01

Esta revisión pretende profundizar en el conocimiento del gasto cardíaco, sus variables y sus condicionantes, así como repasar exhaustivamente las diferentes técnicas disponibles para su monitorización y establecer las situaciones en que el conocimiento del gasto cardíaco nos aporta una información fundamental en el manejo del paciente crítico. La técnica de Fick, utilizada en los inicios para calcular el gasto cardíaco de los pacientes, ha sido sustituida hoy en día en la práctica clínica po...

Recommendations for fluorescence instrument qualification: the new ASTM Standard Guide.

Science.gov (United States)

DeRose, Paul C; Resch-Genger, Ute

2010-03-01

Aimed at improving quality assurance and quantitation for modern fluorescence techniques, ASTM International (ASTM) is about to release a Standard Guide for Fluorescence, reviewed here. The guide's main focus is on steady state fluorometry, for which available standards and instrument characterization procedures are discussed along with their purpose, suitability, and general instructions for use. These include the most relevant instrument properties needing qualification, such as linearity and spectral responsivity of the detection system, spectral irradiance reaching the sample, wavelength accuracy, sensitivity or limit of detection for an analyte, and day-to-day performance verification. With proper consideration of method-inherent requirements and limitations, many of these procedures and standards can be adapted to other fluorescence techniques. In addition, procedures for the determination of other relevant fluorometric quantities including fluorescence quantum yields and fluorescence lifetimes are briefly introduced. The guide is a clear and concise reference geared for users of fluorescence instrumentation at all levels of experience and is intended to aid in the ongoing standardization of fluorescence measurements.

The CFTR-Associated Ligand Arrests the Trafficking of the Mutant ΔF508 CFTR Channel in the ER Contributing to Cystic Fibrosis

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Emily Bergbower

2018-01-01

Full Text Available Background/Aims: The CFTR-Associated Ligand (CAL, a PDZ domain containing protein with two coiled-coil domains, reduces cell surface WT CFTR through degradation in the lysosome by a well-characterized mechanism. However, CAL’s regulatory effect on ΔF508 CFTR has remained almost entirely uninvestigated. Methods: In this study, we describe a previously unknown pathway for CAL by which it regulates the membrane expression of ΔF508 CFTR through arrest of ΔF508 CFTR trafficking in the endoplasmic reticulum (ER using a combination of cell biology, biochemistry and electrophysiology. Results: We demonstrate that CAL is an ER localized protein that binds to ΔF508 CFTR and is degraded in the 26S proteasome. When CAL is inhibited, ΔF508 CFTR retention in the ER decreases and cell surface expression of mature functional ΔF508 CFTR is observed alongside of enhanced expression of plasma membrane scaffolding protein NHERF1. Chaperone proteins regulate this novel process, and ΔF508 CFTR binding to HSP40, HSP90, HSP70, VCP, and Aha1 changes to improve ΔF508 CFTR cell surface trafficking. Conclusion: Our results reveal a pathway in which CAL regulates the cell surface availability and intracellular retention of ΔF508 CFTR.

10 CFR 434.508 - Determination of the design energy consumption and design energy cost.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Determination of the design energy consumption and design... Alternative § 434.508 Determination of the design energy consumption and design energy cost. 508.1The Design Energy Consumption shall be calculated by modeling the Proposed Design using the same methods...

ASTM international workshop on standards and measurements for tissue engineering scaffolds.

Science.gov (United States)

Simon, Carl G; Yaszemski, Michael J; Ratcliffe, Anthony; Tomlins, Paul; Luginbuehl, Reto; Tesk, John A

2015-07-01

The "Workshop on Standards & Measurements for Tissue Engineering Scaffolds" was held on May 21, 2013 in Indianapolis, IN, and was sponsored by the ASTM International (ASTM). The purpose of the workshop was to identify the highest priority items for future standards work for scaffolds used in the development and manufacture of tissue engineered medical products (TEMPs). Eighteen speakers and 78 attendees met to assess current scaffold standards and to prioritize needs for future standards. A key finding was that the ASTM TEMPs subcommittees (F04.41-46) have many active "guide" documents for educational purposes, but few standard "test methods" or "practices." Overwhelmingly, the most clearly identified need was standards for measuring the structure of scaffolds, followed by standards for biological characterization, including in vitro testing, animal models and cell-material interactions. The third most pressing need was to develop standards for assessing the mechanical properties of scaffolds. Additional needs included standards for assessing scaffold degradation, clinical outcomes with scaffolds, effects of sterilization on scaffolds, scaffold composition, and drug release from scaffolds. Discussions highlighted the need for additional scaffold reference materials and the need to use them for measurement traceability. Workshop participants emphasized the need to promote the use of standards in scaffold fabrication, characterization, and commercialization. Finally, participants noted that standards would be more broadly accepted if their impact in the TEMPs community could be quantified. Many scaffold standard needs have been identified and focus is turning to generating these standards to support the use of scaffolds in TEMPs. © 2014 Wiley Periodicals, Inc.

A Knowledge- Based Computer System for UO2 Characterization According to ASTM Requirements

International Nuclear Information System (INIS)

Afifi, Y.K.; El-Hakim, E.

2000-01-01

The uranium dioxde (UO 2 ) powder properties and the pellets fabrication processes determine the characteristics of the sintered UO 2 pellets. The powder properties include chemical and physical characteristics. The physical and chemical properties of UO 2 powder are normally checked to ensure consistency and reproducibility of the sintered UO 2 pellets. Powder characteristics are known to influence the subsequent manufacturing performance or the fuel properties. The aim of this paper is to provide the nuclear industry with a program dealing with the processes and the related requirements to determine the specifications of UO 2 powder according to the American Standards for Testing and Materials (ASTM). This program covers the physical and chemical characteristics of UO 2 powder. A group of logic flow charts dealing with the data and information available in the ASTM for each step in the characterization of UO 2 powder process and the technical assistance are constructed. These logic flow charts are collected to form a module of the software to qualify the UO 2 powder. The program contains 8 modules, each one deals with one object. This program saves time, is also considered as a collective schema for all the required UO 2 powder characterization and the related processes, and could be used as a training tool for less skilled personnel involved in UO 2 powder characterization laboratories

Changes in health care spending and quality for Medicare beneficiaries associated with a commercial ACO contract.

Science.gov (United States)

McWilliams, J Michael; Landon, Bruce E; Chernew, Michael E

2013-08-28

In a multipayer system, new payment incentives implemented by one insurer for an accountable care organization (ACO) may also affect spending and quality of care for another insurer's enrollees served by the ACO. Such spillover effects reflect the extent of organizational efforts to reform care delivery and can contribute to the net impact of ACOs. We examined whether the Blue Cross Blue Shield (BCBS) of Massachusetts' Alternative Quality Contract (AQC), an early commercial ACO initiative associated with reduced spending and improved quality for BCBS enrollees, was also associated with changes in spending and quality for Medicare beneficiaries, who were not covered by the AQC. Quasi-experimental comparisons from 2007-2010 of elderly fee-for-service Medicare beneficiaries in Massachusetts (1,761,325 person-years) served by 11 provider organizations entering the AQC in 2009 or 2010 (intervention group) vs beneficiaries served by other providers (control group). Using a difference-in-differences approach, we estimated changes in spending and quality for the intervention group in the first and second years of exposure to the AQC relative to concurrent changes for the control group. Regression and propensity score methods were used to adjust for differences in sociodemographic and clinical characteristics. The primary outcome was total quarterly medical spending per beneficiary. Secondary outcomes included spending by setting and type of service, 5 process measures of quality, potentially avoidable hospitalizations, and 30-day readmissions. Before entering the AQC, total quarterly spending per beneficiary for the intervention group was $150 (95% CI, $25-$274) higher than for the control group and increased at a similar rate. In year 2 of the intervention group's exposure to the AQC, this difference was reduced to $51 (95% CI, -$109 to $210; P = .53), constituting a significant differential change of -$99 (95% CI, -$183 to -$16; P = .02) or a 3.4% savings

Citrus CitNAC62 cooperates with CitWRKY1 to participate in citric acid degradation via up-regulation of CitAco3.

Science.gov (United States)

Li, Shao-Jia; Yin, Xue-Ren; Wang, Wen-Li; Liu, Xiao-Fen; Zhang, Bo; Chen, Kun-Song

2017-06-15

Citric acid is the predominant organic acid of citrus fruit. Degradation of citric acid occurs during fruit development, influencing fruit acidity. Associations of CitAco3 transcripts and citric acid degradation have been reported for citrus fruit. Here, transient overexpression of CitAco3 significantly reduced the citric acid content of citrus leaves and fruits. Using dual luciferase assays, it was shown that CitNAC62 and CitWRKY1 could transactivate the promoter of CitAco3. Subcellular localization results showed that CitWRKY1 was located in the nucleus and CitNAC62 was not. Yeast two-hybrid analysis and bimolecular fluorescence complementation (BiFC) assays indicated that the two differently located transcription factors could interact with each other. Furthermore, BiFC showed that the protein-protein interaction occurred only in the nucleus, indicating the potential mobility of CitNAC62 in plant cells. A synergistic effect on citrate content was observed between CitNAC62 and CitWRKY1. Transient overexpression of CitNAC62 or CitWRKY1 led to significantly lower citrate content in citrus fruit. The combined expression of CitNAC62 and CitWRKY1 resulted in lower citrate content compared with the expression of CitNAC62 or CitWRKY1 alone. The transcript abundance of CitAco3 was consistent with the citrate content. Thus, we propose that a complex of CitWRKY1 and CitNAC62 contributes to citric acid degradation in citrus fruit, potentially via modulation of CitAco3. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Taponamiento cardíaco secundario a carcinoma papilar esclerosante difuso de tiroides

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Verónica Riva

2011-12-01

Full Text Available El carcinoma papilar, variante esclerosante difusa, corresponde al 2% de todos los carcinomas papilares de la tiroides. Se caracteriza por comprometer de manera difusa y bilateral a la glándula tiroides. Clínicamente se manifiesta con metástasis ganglionares y pulmonares, afectando predominantemente a mujeres jóvenes. Se describe un caso de taponamiento cardíaco como presentación inicial de un carcinoma papilar de tiroides variante esclerosante difusa. Una mujer de 32 años concurrió al servicio de emergencias médicas refiriendo epigastralgia y tos seca. Durante el examen físico se constató hipotensión arterial, taquicardia y ruidos cardíacos disminuidos. Se realizó un ecocardiograma, observándose derrame pericárdico. Por medio de una pericardiocentesis se obtuvo líquido pericárdico, cuyo análisis mostró células neoplásicas. Durante la evolución la paciente presentó recurrencia del derrame pericárdico por lo que se realizó una ventana pleuropericárdica, detectándose durante la cirugía una lesión nodular subpleural, la cual fue biopsiada e informada posteriormente como una metástasis de carcinoma papilar vinculable a origen tiroideo. Se realizó una tiroidectomía total con linfadenectomía cervical bilateral. El diagnóstico final fue carcinoma papilar, variante esclerosante difusa. Esta variante infiltra el tejido conectivo de los espacios interfoliculares, simulando una tiroiditis y se caracteriza por una permeación vascular temprana. En oposición a la variante clásica, la esclerosante difusa presenta mayor agresividad y mayor tasa de recurrencia. El carcinoma papilar de tiroides debe tenerse presente como diagnóstico diferencial en nuestro medio, en todas aquellas lesiones neoplásicas papilares metastásicas, más aún si se trata de mujeres jóvenes.

Transfer function fitting using a continuous Ant Colony Optimization (ACO algorithm

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A. Reineix

2015-03-01

Full Text Available An original approach is proposed in order to achieve the  fitting of ultra-wideband complex frequency functions, such  as the complex impedances, by using the so-called ACO  (Ant Colony Optimization methods. First, we present the  optimization principle of ACO, which originally was  dedicated to the combinatorial problems. Further on, the  extension to the continuous and mixed problems is  explained in more details. The interest in this approach is  proved by its ability to define practical constraints and  objectives, such as minimizing the number of filters used in  the model with respect to a fixed relative error. Finally, the  establishment of the model for the first and second order  filter types illustrates the power of the method and its  interest for the time-domain electromagnetic computation.

Comparative field permeability measurement of permeable pavements using ASTM C1701 and NCAT permeameter methods.

Science.gov (United States)

Li, Hui; Kayhanian, Masoud; Harvey, John T

2013-03-30

Fully permeable pavement is gradually gaining support as an alternative best management practice (BMP) for stormwater runoff management. As the use of these pavements increases, a definitive test method is needed to measure hydraulic performance and to evaluate clogging, both for performance studies and for assessment of permeability for construction quality assurance and maintenance needs assessment. Two of the most commonly used permeability measurement tests for porous asphalt and pervious concrete are the National Center for Asphalt Technology (NCAT) permeameter and ASTM C1701, respectively. This study was undertaken to compare measured values for both methods in the field on a variety of permeable pavements used in current practice. The field measurements were performed using six experimental section designs with different permeable pavement surface types including pervious concrete, porous asphalt and permeable interlocking concrete pavers. Multiple measurements were performed at five locations on each pavement test section. The results showed that: (i) silicone gel is a superior sealing material to prevent water leakage compared with conventional plumbing putty; (ii) both methods (NCAT and ASTM) can effectively be used to measure the permeability of all pavement types and the surface material type will not impact the measurement precision; (iii) the permeability values measured with the ASTM method were 50-90% (75% on average) lower than those measured with the NCAT method; (iv) the larger permeameter cylinder diameter used in the ASTM method improved the reliability and reduced the variability of the measured permeability. Copyright © 2013 Elsevier Ltd. All rights reserved.

Cavitation erosion - corrosion behaviour of ASTM A27 runner steel in natural river water

International Nuclear Information System (INIS)

Tôn-Thât, L

2014-01-01

Cavitation erosion is still one of the most important degradation modes in hydraulic turbine runners. Part of researches in this field focuses on finding new materials, coatings and surface treatments to improve the resistance properties of runners to this phenomenon. However, only few studies are focused on the deleterious effect of the environment. Actually, in some cases a synergistic effect between cavitation erosion mechanisms and corrosion kinetics can establish and increase erosion rate. In the present study, the cavitation erosion-corrosion behaviour of ASTM A27 steel in natural river water is investigated. This paper state the approach which has been used to enlighten the synergy between both phenomena. For this, a 20 kHz vibratory test according ASTM G32 standard is coupled to an electrochemical cell to be able to follow the different corrosion parameters during the tests to get evidence of the damaging mechanism. Moreover, mass losses have been followed during the exposure time. The classical degradation parameters (cumulative weight loss and erosion rate) are determined. Furthermore, a particular effort has been implemented to determine the evolution of surface damages in terms of pitting, surface cracking, material removal and surface corrosion. For this, scanning electron microscopy has been used to link the microstructure to the material removal mechanisms

Evaluation of the Precipitation Behavior in SA508 Gr. 4N Low Alloy Steel Using a Thermodynamic Calculation

International Nuclear Information System (INIS)

Park, Sang Gyu; Wee, Dang Moon; Kim, Min Chul; Lee, Bong Sang

2007-01-01

Low carbon low alloy steels, used as nuclear pressure vessels, steam generators and so on, hold a large portion of materials for nuclear power plants, and they are very important materials since they determine the safety and the life span of nuclear power plants. In addition, they are utilized for a long period under very severe conditions such as a high pressure, high temperature, neutron irradiation and corrosion, so they need a good combination of strength and toughness, a good weldability and an excellent neutron irradiation resistance and so on. SA508 Gr.3 steel shows the upper bainite microstructure, which is a less tough, so the steel is more difficult to obtain good toughness than to have good strength. And then, if a loss of toughness due to a neutron irradiation during service is considered, above all improving the toughness is important when a pressure vessel is fabricated It is known that a higher strength and fracture toughness of low alloy steels could be achieved by increasing the Ni and Cr contents. In this study, we have performed a thermodynamic calculation based on the microstructure of SA508 Gr.4N low alloy steel which has higher Ni and Cr contents than SA508 Gr.3 low alloy steel. Based on the microstructure/property relations obtained from literature research experimental works on SA508 Gr.4N steels, and by predicting the constitutional changes with alloying elements (such as Mn, Cr) during individual steps of a steel making process a using thermodynamic calculation, fundamental information for an alloy design have been discussed

5 CFR 9701.508 - Homeland Security Labor Relations Board.

Science.gov (United States)

2010-01-01

... MANAGEMENT SYSTEM (DEPARTMENT OF HOMELAND SECURITY-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT SYSTEM Labor-Management Relations § 9701.508 Homeland Security Labor... impression or a major policy. (2) In cases where the full HSLRB acts, a vote of the majority of the HSLRB (or...

Registro Español de Trasplante Cardíaco. XX Informe oficial de la sección de insuficiencia Cardíaca y Trasplante Cardíaco de la sociedad Española de Cardiología (1984-2008

Directory of Open Access Journals (Sweden)

Luis Almenar Bonet

2009-07-01

Conclusiones: La supervivencia obtenida en España con el TC, sobre todo en los últimos años, sitúa al trasplante cardíaco como el tratamiento de elección para cardiopatías irreversibles en situación funcional avanzada y sin otras opciones médicas o quirúrgicas establecidas.

Autotransplante cardíaco: um novo método no tratamento de problemas cardíacos complexos Heart autotransplantation: a new technique to complex intracardiac reppairs

Directory of Open Access Journals (Sweden)

Randas J. V Batista

1995-06-01

Full Text Available No período de janeiro de 1990 a maio de 1995 foram operados com a técnica do autotransplante cardíaco 92 pacientes com cardiopatias complexas e arritmias supraventriculares, principalmente fibrilação atrial (n=89, reentrada (n=2, QT longo (n=1. O sexo feminino predominou (n=63. A idade variou de 18 a 76 anos (m=43. Os defeitos concomitantes foram: átrio esquerdo gigante (medido pelo ecocardiograma > 6 cm (n=65; átrio direito gigante (n=9; átrio esquerdo aumentado (4 cm (n=23; estenose mitral (n=46; insuficiência mitral (n=28; dupla lesão mitral (n=16; estenose aórtica (n=12; insuficiência aórtica (n=5; insuficiência tricúspide (n=78; trombose atrial (n=23; calcificação atrial (n=12; hipertensão pulmonar (n=86; fibroelastose biventricular (n=3; rotura atrioventricular (pós-troca de valva mitral (n=1; aneurisma da raiz aórtica (n=1; ventriculectomia parcial (n=8; 88 pacientes saíram do centro cirúrgico em ritmo sinusal e assim permaneceram; 6 precisaram de drogas inotrópicas e 3 de drogas antiarrítmicas. Todos os pacientes que apresentavam átrio esquerdo ou direito gigante com fibrilação atrial tiveram seus átrios reduzidos ao tamanho normal. Não houve mortalidade operatória e 6 evoluíram a óbito hospitalar. Na reavaliação aos seis meses de pós-operatório, os sobreviventes estavam bem, em ritmo sinusal. A técnica do autotransplante cardíaco facilita o reparo intracardíaco, proporciona a redução atrial e conseqüente retorno do paciente ao ritmo sinusal e abre novas perspectivas.From January 1990 to May 1995,92 patients with complex cardiac problems and supraventricular arrhythmias were operated upon with the technique of heart autotransplantation. The arrhythmias were: atrial fibrillation (n=89; reentry (n=2; long QT syndrome (n=1. Females predominated (n=63. The age varied from 18 to 76 years (m=43. Concomittant defects were: giant left atrium (> 6 cm measured by echo (n=65; giant right atrium (n=9; large

Qualidade de vida de pacientes submetidos ao transplante cardíaco: aplicação da escala Whoqol-Bref

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Maria Isis Freire de Aguiar

2011-01-01

Full Text Available FUNDAMENTO: O sucesso do transplante cardíaco significa garantir a sobrevida dos pacientes com cardiopatia e permitir-lhes desenvolver suas atividades diárias. O transplante cardíaco apresenta-se como a primeira opção de tratamento na falência cardíaca, representando um aumento de sobrevida e qualidade de vida dos transplantados. OBJETIVO: Avaliar a qualidade de vida de pacientes submetidos ao transplante cardíaco através da aplicação de uma escala padronizada (Whoqol-Bref. MÉTODOS: Estudo exploratório descritivo de abordagem quantitativa, realizado com 55 pacientes submetidos ao transplante cardíaco, em um período entre o terceiro e o 103º mês, que realizam acompanhamento na Unidade de Transplante e Insuficiência Cardíaca em um Hospital de Referência em Cardiologia na cidade de Fortaleza, CE. Os dados foram coletados no período de fevereiro a abril de 2009, por meio da aplicação de um questionário padronizado pela Organização Mundial da Saúde e utilização de dados constantes nos prontuários. RESULTADOS: Com relação ao domínio físico, 62,8% e 58,3% dos pacientes, dos sexos masculino e feminino, respectivamente, estão satisfeitos. No domínio psicológico, dentre pacientes do sexo masculino, 65,1% apresentam satisfação quanto à qualidade de vida e, no sexo feminino, 58,3% encontram-se satisfeitas. No domínio das relações sociais, observou-se que, no sexo masculino, 53,5% estão muito satisfeitos, e apresentou-se um nível de satisfação de 100% no sexo feminino. No domínio do meio ambiente, 65,1% do sexo masculino encontram-se satisfeitos, e no sexo feminino, 83,3% estão satisfeitas. CONCLUSÃO: O transplante cardíaco teve bastante influência na qualidade de vida dos pacientes transplantados, pois os resultados mostram-se estatisticamente significantes no pós-transplante.

Vacuum decay container/closure integrity testing technology. Part 1. ASTM F2338-09 precision and bias studies.

Science.gov (United States)

Wolf, Heinz; Stauffer, Tony; Chen, Shu-Chen Y; Lee, Yoojin; Forster, Ronald; Ludzinski, Miron; Kamat, Madhav; Godorov, Phillip; Guazzo, Dana Morton

2009-01-01

ASTM F2338-09 Standard Test Method for Nondestructive Detection of Leaks in Packages by Vacuum Decay Method is applicable for leak-testing rigid and semi-rigid non-lidded trays; trays or cups sealed with porous barrier lidding materials; rigid, nonporous packages; and flexible, nonporous packages. Part 1 of this series describes the precision and bias studies performed in 2008 to expand this method's scope to include rigid, nonporous packages completely or partially filled with liquid. Round robin tests using three VeriPac 325/LV vacuum decay leak testers (Packaging Technologies & Inspection, LLC, Tuckahoe, NY) were performed at three test sites. Test packages were 1-mL glass syringes. Positive controls had laser-drilled holes in the barrel ranging from about 5 to 15 microm in nominal diameter. Two different leak tests methods were performed at each site: a "gas leak test" performed at 250 mbar (absolute) and a "liquid leak test" performed at about 1 mbar (absolute). The gas leak test was used to test empty, air-filled syringes. All defects with holes > or = 5.0 microm and all no-defect controls were correctly identified. The only false negative result was attributed to a single syringe with a ASTM F2338-09 test method and the precision and bias study report are available by contacting ASTM International in West Conshohocken, PA, USA (www.astm.org).

48 CFR 3045.508-2 - Reporting results of inventories.

Science.gov (United States)

2010-10-01

...: (1) Land and rights therein; (2) Other real property; (3) Plant equipment; (4) Special test equipment... SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 3045.508-2 Reporting results of...

Fretting-corrosion at the modular tapers interface: Inspection of standard ASTM F1875-98.

Science.gov (United States)

Bingley, Rachel; Martin, Alan; Manfredi, Olivia; Nejadhamzeeigilani, Mahdiyar; Oladokun, Abimbola; Beadling, Andrew Robert; Siddiqui, Sohail; Anderson, James; Thompson, Jonathan; Neville, Anne; Bryant, Michael

2018-05-01

Interest in the degradation mechanisms at the modular tapers interfaces has been renewed due to increased reported cases of adverse reactions to metal debris and the appearance of wear and corrosion at the modular tapers interfaces at revision. Over the past two decades, a lot of research has been expended to understand the degradation mechanisms, with two primary implant loading procedures and orientations used consistently across the literature. ASTM F1875-98 is often used as a guide to understand and benchmark the tribocorrosion processes occurring within the modular tapers interface. This article presents a comparison of the two methods outlined in ASTM F1875-98 as well as a critique of the standard considering the current paradigm in pre-clinical assessment of modular tapers.

Characterization of nasal potential difference in cftr knockout and F508del-CFTR mice.

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Emilie Lyne Saussereau

Full Text Available BACKGROUND: Treatments designed to correct cystic fibrosis transmembrane conductance regulator (CFTR defects must first be evaluated in preclinical experiments in the mouse model of cystic fibrosis (CF. Mice nasal mucosa mimics the bioelectric defect seen in humans. The use of nasal potential difference (V(TE to assess ionic transport is a powerful test evaluating the restoration of CFTR function. Nasal V(TE in CF mice must be well characterized for correct interpretation. METHODS: We performed V(TE measurements in large-scale studies of two mouse models of CF--B6;129 cftr knockout and FVB F508del-CFTR--and their respective wild-type (WT littermates. We assessed the repeatability of the test for cftr knockout mice and defined cutoff points distinguishing between WT and F508del-CFTR mice. RESULTS: We determined the typical V(TE values for CF and WT mice and demonstrated the existence of residual CFTR activity in F508del-CFTR mice. We characterized intra-animal variability in B6;129 mice and defined the cutoff points for F508del-CFTR chloride secretion rescue. Hyperpolarization of more than -2.15 mV after perfusion with a low-concentration Cl(- solution was considered to indicate a normal response. CONCLUSIONS: These data will make it possible to interpret changes in nasal V(TE in mouse models of CF, in future preclinical studies.

Avaliação da doença vascular do enxerto no transplante cardíaco: experiência de um centro brasileiro

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Elide Sbardellotto Mariano da Costa

2012-10-01

Full Text Available FUNDAMENTO: O transplante cardíaco continua sendo o tratamento de escolha para a insuficiência cardíaca refratária ao tratamento otimizado. Dois métodos diagnósticos apresentam elevada sensibilidade no diagnóstico de episódios de rejeição ao enxerto e Doença Vascular do Enxerto (DVE, causas importantes de mortalidade no pós-transplante. OBJETIVO: Avaliar a relação entre os resultados do ultrassom intracoronariano (USIV e os laudos das biópsias endomiocárdicas (BX no seguimento de pacientes submetidos a transplante cardíaco em um serviço de referência brasileiro. MÉTODOS: Foi realizado um ensaio epidemiológico retrospectivo observacional, com pacientes submetidos a transplante cardíaco ortotópico, no período de 2000 a 2009. Foram analisados os prontuários desses pacientes e os resultados dos USIV e BX realizados rotineiramente no seguimento clínico pós-transplante e terapêutica em uso. RESULTADOS: Dos 77 pacientes analisados, 63,63% são do sexo masculino, nas faixas etárias de 22 a 69 anos. Quanto aos resultados dos USIV, 33,96% foram classificados em Stanford classe I, e 32,08%, como Stanford IV. Dos 143 laudos das biópsias, 51,08% tiveram resultado 1R, 3R em 0,69% dos laudos, e 14,48% apresentaram a descrição de efeito Quilty. Todos usaram antiproliferativos, 80,51% usaram inibidores da calcineurina e 19,48% usaram inibidores do sinal de proliferação (ISP. CONCLUSÃO: A avaliação dos pacientes pós-transplante cardíaco por meio do USIV incorpora informações detalhadas para o diagnóstico precoce e sensível da DVE, que são complementadas pelas informações histológicas fornecidas pelas BX, estabelecendo uma possível relação causal entre a DVE e os episódios de rejeição humoral.

Corrosion resistance and microstructure of alloy 625 weld overlay on ASTM A516 grade 70

Energy Technology Data Exchange (ETDEWEB)

Moradi, Mohammad J. [Amirkabir Univ. of Technology, Tehran (Iran, Islamic Republic of). Petroleum Engineering Dept.; Ketabchi, Mostafa [Amirkabir Univ. of Technology, Tehran (Iran, Islamic Republic of). Mining and Metallurgical Engineering Dept.

2016-02-01

Nickel-based alloys are a crucial class of materials because of their excellent corrosion resistance. In the present study, single layer and two layers alloy 625 weld overlays were deposited by GTAW process on A516 grade 70 carbon steel. The dilution in terms of Fe, Ni, Mo and Nb content was calculated in 30 points of weld overlay. Microstructure observations showed that alloy 625 had austenitic structure with two types of Laves and NbC secondary phases. The uniform and pitting corrosion resistance of alloy 625 weld overlay as casted and as forged were evaluated in accordance with ASTM G48-2011 standard at different temperatures to determine the weight loss and critical pitting temperature. For achieving a better comparison, samples from alloy 625 as casted and as forged were tested under the same conditions. The results point out that single layer alloy 625 weld overlay is not suitable for chloride containing environments, two layers alloy 625 weld overlay and alloy 625 as casted have acceptable corrosion resistance and almost the same critical pitting temperature. Alloy 625 as forged has the best corrosion resistance and the highest critical pitting temperature among all test specimens. Also, the corrosion behavior was evaluated in accordance with ASTM G28 standard. The corrosion rate of single layer weld overlay was unacceptable. The average corrosion rate of two layers weld overlay and in casted condition were 35.82 and 33.01 mpy, respectively. [German] Nickellegierungen sind aufgrund ihres exzellenten Korrosionswiderstandes eine bedeutende Werkstoffklasse. In der diesem Beitrag zugrunde liegenden Studie wurden mittels WIG-Schweissens ein- und zweilagige Schweissplattierungen auf den Kohlenstoffstahl A516 (Grade 70) aufgebracht. Die Vermischung in Form des Fe-, Ni-, Mo- und Nb-Gehaltes wurde an 30 Punkten der Schweissplattierungen berechnet. Die mikrostrukturellen Untersuchungen ergaben, dass die Legierung 625 eine austenitische Struktur mit zwei Arten von

Overview (this manuscript is an overview of an ASTM ...

Science.gov (United States)

The Symposium on Developing Consensus Standards for Measuring Chemical Emissions from Spray Polyurethane Foam (SPF) Insulation was held on April 30th and May 1, 2015. Sponsored by ASTM Committee D22 on Air Quality, the symposium was held in Anaheim, CA, in conjunction with the standards development meetings of the Committee. ASTM D22.05 is developing tools to answer fundamental questions: what is emitted from SPF, how long do the emissions persist, how does ventilation impact concentrations and potential exposures? How can we model these processes to address the multiplicity of products, applications, and environmental conditions that may impact exposure to emissions over the life cycle of the material? These are complex and interrelated questions that have challenged the indoor environments research community for many years. Objectives of Symposium: Standardized methods are needed to assess the potential impacts of SPF insulation products on indoor air quality, establish re-entry times for trade workers or re-occupancy times for building occupants after product installation and to evaluate post-occupancy ventilation. The objective of the symposium was to provide a forum for the exchange of ideas from SPF manufacturers, regulatory agencies, indoor air quality professionals, testing labs, air quality consultants, instrument vendors and other stakeholders. Following the presentations on the current status of measuring emissions from SPF insulation, participants di

ASTM clustering for improving coal analysis by near-infrared spectroscopy.

Science.gov (United States)

Andrés, J M; Bona, M T

2006-11-15

Multivariate analysis techniques have been applied to near-infrared (NIR) spectra coals to investigate the relationship between nine coal properties (moisture (%), ash (%), volatile matter (%), fixed carbon (%), heating value (kcal/kg), carbon (%), hydrogen (%), nitrogen (%) and sulphur (%)) and the corresponding predictor variables. In this work, a whole set of coal samples was grouped into six more homogeneous clusters following the ASTM reference method for classification prior to the application of calibration methods to each coal set. The results obtained showed a considerable improvement of the error determination compared with the calibration for the whole sample set. For some groups, the established calibrations approached the quality required by the ASTM/ISO norms for laboratory analysis. To predict property values for a new coal sample it is necessary the assignation of that sample to its respective group. Thus, the discrimination and classification ability of coal samples by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) in the NIR range was also studied by applying Soft Independent Modelling of Class Analogy (SIMCA) and Linear Discriminant Analysis (LDA) techniques. Modelling of the groups by SIMCA led to overlapping models that cannot discriminate for unique classification. On the other hand, the application of Linear Discriminant Analysis improved the classification of the samples but not enough to be satisfactory for every group considered.

31 CFR 535.420 - Transfers of accounts under § 535.508 from demand to interest-bearing status.

Science.gov (United States)

2010-07-01

....508 from demand to interest-bearing status. 535.420 Section 535.420 Money and Finance: Treasury... from demand to interest-bearing status. Section 535.508 authorizes transfer of a blocked demand deposit account to interest-bearing status at the instruction of the Iranian depositor at any time. [44 FR 76784...

Biophysical characterisation of calumenin as a charged F508del-CFTR folding modulator.

Directory of Open Access Journals (Sweden)

Rashmi Tripathi

Full Text Available The cystic fibrosis transmembrane regulator (CFTR is a cyclic-AMP dependent chloride channel expressed at the apical surface of epithelial cells lining various organs such as the respiratory tract. Defective processing and functioning of this protein caused by mutations in the CFTR gene results in loss of ionic balance, defective mucus clearance, increased proliferation of biofilms and inflammation of human airways observed in cystic fibrosis (CF patients. The process by which CFTR folds and matures under the influence of various chaperones in the secretory pathway remains incompletely understood. Recently, calumenin, a secretory protein, belonging to the CREC family of low affinity calcium binding proteins has been identified as a putative CFTR chaperone whose biophysical properties and functions remain uncharacterized. We compared hydropathy, instability, charge, unfoldability, disorder and aggregation propensity of calumenin and other CREC family members with CFTR associated chaperones and calcium binding proteins, wild-type and mutant CFTR proteins and intrinsically disordered proteins (IDPs. We observed that calumenin, along with other CREC proteins, was significantly more charged and less folded compared to CFTR associated chaperones. Moreover like IDPs, calumenin and other CREC proteins were found to be less hydrophobic and aggregation prone. Phylogenetic analysis revealed a close link between calumenin and other CREC proteins indicating how evolution might have shaped their similar biophysical properties. Experimentally, calumenin was observed to significantly reduce F508del-CFTR aggregation in a manner similar to AavLEA1, a well-characterized IDP. Fluorescence microscopy based imaging analysis also revealed altered trafficking of calumenin in bronchial cells expressing F508del-CFTR, indicating its direct role in the pathophysiology of CF. In conclusion, calumenin is characterized as a charged protein exhibiting close similarity with

Comparison of SA508 Gr.3 and SA508 Gr.4N Low Alloy Steels for Reactor Pressure Vessel Steel

Energy Technology Data Exchange (ETDEWEB)

Kim, Min Chul; Lee, B. S

2009-12-15

The microstructural characteristics and mechanical properties of SA508 Gr.3 Mn-Mo-Ni low alloy steel and SA508 Gr.4N Ni-Mo-Cr low alloy steel were investigated. The differences in the stable phases between these two low alloy steels were evaluated by means of a thermodynamic calculation using ThermoCalc. They were then compared to microstructural features and correlated with mechanical properties. Mn-Mo-Ni low alloy steel shows the upper bainite structure which has the coarse cementite in the lath boundaries. However, Ni-Mo-Cr low alloy steel shows the mixture of lower bainite and tempered martensite structure that homogeneously precipitates the small carbides such as M{sub 23}C{sub 6} and M{sub 7}C{sub 3} due to an increase of hardenability and Cr addition. In the mechanical properties, Ni-Mo-Cr low alloy steel has higher strength and toughness than Mn-Mo-Ni low alloy steel. Ni and Cr additions increase the strength by solid solution hardening. Besides, microstructural changes from upper bainite to tempered martensite improve the strength of the low alloy steel by grain refining effect. And the changes in the precipitation behavior by Cr addition improve the ductile-brittle transition behavior along with a toughening effect of Ni addition.

The Intricate Structure of HH 508, the Brightest Microjet in the Orion Nebula

Science.gov (United States)

Wu, Ya-Lin; Close, Laird M.; Kim, Jinyoung Serena; Males, Jared R.; Morzinski, Katie M.

2018-02-01

We present Magellan adaptive optics Hα imaging of HH 508, which has the highest surface brightness among protostellar jets in the Orion Nebula. We find that HH 508 actually has a shorter component to the west, and a longer and knotty component to the east. The east component has a kink at 0.″3 from the jet-driving star θ 1 Ori B2, so it may have been deflected by the wind/radiation from the nearby θ 1 Ori B1B5. The origin of both components is unclear, but if each of them is a separate jet, then θ 1 Ori B2 may be a tight binary. Alternatively, HH 508 may be a slow-moving outflow, and each component represents an illuminated cavity wall. The ionization front surrounding θ 1 Ori B2B3 does not directly face θ 1 Ori B1B5, suggesting that the EUV radiation from θ 1 Ori C plays a dominant role in affecting the morphology of proplyds even in the vicinity of θ 1 Ori B1B5. Finally, we report an Hα blob that might be ejected by the binary proplyd LV 1.

Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental

Directory of Open Access Journals (Sweden)

Julio E. Enders

1995-02-01

Full Text Available Experimental Chagas' disease (45 to 90 days post-infection showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase. Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control p Estudaram-se os receptores beta cardíacos de camundongos infectados pelo Trypanosoma cruzi na fase pós-aguda da doença de Chagas para estabelecer em que medida os mesmos contribuem a gerar respostas anômalas às catecolaminas observadas nestes miocardios. Utilizara-se 3-H/DHA para a marcação dos receptores beta cardíacos dos camundongos normais e dos infectados na fase pós-aguda (45 a 90 dias pós-infecção. O número dos sítios de fixação foi similar nos dois grupos, 78.591 ± 3.125 fmol/mg. Proteína nos chagásicos e 73.647 ± 2.194 fmol/mg. Proteína no grupo controle. Em vez disso, a afinidade verificou-se significativamente diminuida no grupo chagásico (Kd = 7.299 ± 0.426 nM respeito do controle (Kd = 3.759 ± 0.212 nM p < 0.001. Os resultados obtidos demonstram que as modificações observadas na estimulação adrenérgica do miocárdio chagásico se correlacionam com a menor afinidade dos receptores beta cardíacos e que estas alterações exerceriam uma parte determinante para as consequências funcionais que são detectadas na fase crônica.

30 CFR 285.508 - What rent payments must I pay on ROW grants or RUE grants associated with renewable energy projects?

Science.gov (United States)

2010-07-01

... RUE grants associated with renewable energy projects? 285.508 Section 285.508 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF... § 285.508 What rent payments must I pay on ROW grants or RUE grants associated with renewable energy...

Considerations on the ASTM standards 1789-04 and 1422-05 on the forensic examination of ink.

Science.gov (United States)

Neumann, Cedric; Margot, Pierre

2010-09-01

The ASTM standards on Writing Ink Identification (ASTM 1789-04) and on Writing Ink Comparison (ASTM 1422-05) are the most up-to-date guidelines that have been published on the forensic analysis of ink. The aim of these documents is to cover most aspects of the forensic analysis of ink evidence, from the analysis of ink samples, the comparison of the analytical profile of these samples (with the aim to differentiate them or not), through to the interpretation of the result of the examination of these samples in a forensic context. Significant evolutions in the technology available to forensic scientists, in the quality assurance requirements brought onto them, and in the understanding of frameworks to interpret forensic evidence have been made in recent years. This article reviews the two standards in the light of these evolutions and proposes some practical improvements in terms of the standardization of the analyses, the comparison of ink samples, and the interpretation of ink examination. Some of these suggestions have already been included in a DHS funded project aimed at creating a digital ink library for the United States Secret Service. © 2010 American Academy of Forensic Sciences.

31 CFR 560.508 - Telecommunications and mail transactions authorized.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Telecommunications and mail... REGULATIONS Licenses, Authorizations and Statements of Licensing Policy § 560.508 Telecommunications and mail... telecommunications and mail between the United States and Iran are authorized. For purposes of this section, the term...

Anodic Protection performance of Steels ASTM A 516-60 And JIS G 3131 SPHC In Concentrated Sulfuric Acid

International Nuclear Information System (INIS)

Harsisto; Ginting, Immanuel; Eddy, D.C

2001-01-01

One of the methods to protect a carbon steel material from corrosion attack of sulfuric acid environment is with anodic protection. This research was intended to investigate the effect of anodic protection quickened with potential polarization, The material under investigation were ASTM A 516 and JIS G 3131-SPHC in highly concentrated H 2 SO 4 solution. The results showed that potential that was effective for anodic protection in ASTM A 516-60 were at 236-436 mV for 75%, 276-476 mV for 80%, 264-514 mV for 85%,285-485 mV for 90%, and 231-431 mV for 97% H 2 SO 4 so that in JlS G 3131-SPHC were at 303 -503 mV for 75%, 290-490 mV for 80%, 269- 516 mV for 85%, 264-514 mV for 90%, and 287 -487 mV for 97% H 2 SO 4

41 CFR 302-3.508 - What relocation expenses are not authorized for new appointees or student trainees?

Science.gov (United States)

2010-07-01

... are not authorized for new appointees or student trainees? 302-3.508 Section 302-3.508 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION... relocation expenses are not authorized for new appointees or student trainees? You must not pay any expenses...

Significados dos episódios maníacos para pacientes com transtorno bipolar em remissão: um estudo qualitativo

Directory of Open Access Journals (Sweden)

Luiz Carlos Pereira Bin

2014-07-01

Full Text Available Objetivo Discutir os significados da vivência de episódios maníacos para pacientes com transtorno bipolar (TAB. Métodos Trata-se de uma pesquisa qualitativa, feita por meio de entrevistas semidirigidas em profundidade, em uma amostra fechada pelo critério de saturação com oito pacientes com TAB em remissão. A técnica de tratamento de dados foi feita por meio da análise de conteúdo das entrevistas transcritas na íntegra e categorização. Os resultados foram submetidos à validação externa, no Laboratório de Pesquisa Clínico-Qualitativa do Departamento de Psicologia Médica e Psiquiatria da Unicamp, composto por 37 pesquisadores do método, entre eles mestrandos, doutorandos, pós-doutorados e pesquisadores seniores. Resultados Foram identificadas três categorias – Ambivalência e vergonha: pensar ou não pensar sobre os episódios maníacos; Organizando sentimentos pessoais: a remissão como um momento de autoconsciência; Episódios maníacos estruturando relações interpessoais versus projeções da angústia. Conclusão Os achados da presente pesquisa contribuem para a maior compreensão dos quadros maníacos no TAB, que podem auxiliar nas reflexões acerca da relação profissional-paciente, para elaborar estratégias para aderência e para as medidas terapêuticas e preventivas da recorrência dos episódios. Podem auxiliar a equipe de saúde envolvida no acompanhamento desses casos e também os pesquisadores na investigação da contribuição dos significados aqui discutidos nos fenômenos de aderência ao tratamento e de um melhor prognóstico.

Qualidade de vida de pacientes submetidos ao transplante cardíaco: aplicação da escala Whoqol-Bref Calidad de vida de pacientes sometidos a transplante cardíaco: aplicación de la escala Whoqol-Bref Quality of life of patients that had a heart transplant: application of Whoqol-Bref scale

Directory of Open Access Journals (Sweden)

Maria Isis Freire de Aguiar

2011-01-01

Full Text Available FUNDAMENTO: O sucesso do transplante cardíaco significa garantir a sobrevida dos pacientes com cardiopatia e permitir-lhes desenvolver suas atividades diárias. O transplante cardíaco apresenta-se como a primeira opção de tratamento na falência cardíaca, representando um aumento de sobrevida e qualidade de vida dos transplantados. OBJETIVO: Avaliar a qualidade de vida de pacientes submetidos ao transplante cardíaco através da aplicação de uma escala padronizada (Whoqol-Bref. MÉTODOS: Estudo exploratório descritivo de abordagem quantitativa, realizado com 55 pacientes submetidos ao transplante cardíaco, em um período entre o terceiro e o 103º mês, que realizam acompanhamento na Unidade de Transplante e Insuficiência Cardíaca em um Hospital de Referência em Cardiologia na cidade de Fortaleza, CE. Os dados foram coletados no período de fevereiro a abril de 2009, por meio da aplicação de um questionário padronizado pela Organização Mundial da Saúde e utilização de dados constantes nos prontuários. RESULTADOS: Com relação ao domínio físico, 62,8% e 58,3% dos pacientes, dos sexos masculino e feminino, respectivamente, estão satisfeitos. No domínio psicológico, dentre pacientes do sexo masculino, 65,1% apresentam satisfação quanto à qualidade de vida e, no sexo feminino, 58,3% encontram-se satisfeitas. No domínio das relações sociais, observou-se que, no sexo masculino, 53,5% estão muito satisfeitos, e apresentou-se um nível de satisfação de 100% no sexo feminino. No domínio do meio ambiente, 65,1% do sexo masculino encontram-se satisfeitos, e no sexo feminino, 83,3% estão satisfeitas. CONCLUSÃO: O transplante cardíaco teve bastante influência na qualidade de vida dos pacientes transplantados, pois os resultados mostram-se estatisticamente significantes no pós-transplante.FUNDAMENTO: El éxito del transplante cardíaco significa garantizar la sobrevida de los pacientes con cardiopatía y permitirles

CCR+: Metadata Based Extended Personal Health Record Data Model Interoperable with the ASTM CCR Standard.

Science.gov (United States)

Park, Yu Rang; Yoon, Young Jo; Jang, Tae Hun; Seo, Hwa Jeong; Kim, Ju Han

2014-01-01

Extension of the standard model while retaining compliance with it is a challenging issue because there is currently no method for semantically or syntactically verifying an extended data model. A metadata-based extended model, named CCR+, was designed and implemented to achieve interoperability between standard and extended models. Furthermore, a multilayered validation method was devised to validate the standard and extended models. The American Society for Testing and Materials (ASTM) Community Care Record (CCR) standard was selected to evaluate the CCR+ model; two CCR and one CCR+ XML files were evaluated. In total, 188 metadata were extracted from the ASTM CCR standard; these metadata are semantically interconnected and registered in the metadata registry. An extended-data-model-specific validation file was generated from these metadata. This file can be used in a smartphone application (Health Avatar CCR+) as a part of a multilayered validation. The new CCR+ model was successfully evaluated via a patient-centric exchange scenario involving multiple hospitals, with the results supporting both syntactic and semantic interoperability between the standard CCR and extended, CCR+, model. A feasible method for delivering an extended model that complies with the standard model is presented herein. There is a great need to extend static standard models such as the ASTM CCR in various domains: the methods presented here represent an important reference for achieving interoperability between standard and extended models.

BER Performance of Stratified ACO-OFDM for Optical Wireless Communications over Multipath Channel

OpenAIRE

Gebeyehu, Zelalem Hailu; Langat, Philip Kibet; Maina, Ciira Wa

2018-01-01

In intensity modulation/direct detection- (IM/DD-) based optical OFDM systems, the requirement of the input signal to be real and positive unipolar imposes a reduction of system performances. Among previously proposed unipolar optical OFDM schemes for optical wireless communications (OWC), asymmetrically clipped optical OFDM (ACO-OFDM) and direct current biased optical OFDM (DCO-OFDM) are the most accepted ones. But those proposed schemes experience either spectral efficiency loss or energy e...

24 CFR 982.508 - Maximum family share at initial occupancy.

Science.gov (United States)

2010-04-01

... URBAN DEVELOPMENT SECTION 8 TENANT BASED ASSISTANCE: HOUSING CHOICE VOUCHER PROGRAM Rent and Housing Assistance Payment § 982.508 Maximum family share at initial occupancy. At the time the PHA approves a... program, and where the gross rent of the unit exceeds the applicable payment standard for the family, the...

Transient absorption spectroscopy in biology using the Super-ACO storage ring FEL and the synchrotron radiation combination

CERN Document Server

Renault, E; De Ninno, G; Garzella, D; Hirsch, M; Nahon, L; Nutarelli, D

2001-01-01

The Super-ACO storage ring FEL, covering the UV range down to 300 nm with a high average power (300 mW at 350 nm) together with a high stability and long lifetime, is a unique tool for the performance of users applications. We present here the first pump-probe two color experiments on biological species using a storage ring FEL coupled to the synchrotron radiation. The intense UV pulse of the Super-ACO FEL is used to prepare a high initial concentration of chromophores in their first singlet electronic excited state. The nearby bending magnet synchrotron radiation provides, on the other hand a pulsed, white light continuum (UV-IR), naturally synchronized with the FEL pulses and used to probe the photochemical subsequent events and the associated transient species. We have demonstrated the feasibility with a dye molecule (POPOP) observing a two-color effect, signature of excited state absorption and a temporal signature with Acridine. Applications on various chromophores of biological interest are carried out,...

Ensaios MSCR segundo as normas ASTM D7405-10a e AASHTO T350-14: um estudo de caso envolvendo ligantes asfálticos modificados

Directory of Open Access Journals (Sweden)

Matheus David Inocente Domingos

2016-12-01

especially the AC+rubber and the AC+rubber+PPA. The AC+PPA showed low stress sensitivity and the best results for the parameters R and Jnr at 3,200 Pa either in the ASTM or the AASHTO protocols, which justifies its choice as the best formulation. The data from the modified asphalt binders suggest that the change from the ASTM protocol to the AASHTO one is recommended.

ASTM Committee D-7 : Wood : promoting safety and standardization for 100 years

Science.gov (United States)

David W. Green; Robert L. Ethington

2004-01-01

In October 2004, Committee D-7 on Wood of the American Society for Testing and Materials (ASTM) is celebrating 100 years of contributions to the safe and efficient use of wood as a building material. Born during a period of rapid social, economic, and technological change, the Committee faced controversial issues and the challenge of a changing forest resource. This...

Dendrimer-based selective autophagy-induction rescues ΔF508-CFTR and inhibits Pseudomonas aeruginosa infection in cystic fibrosis.

Directory of Open Access Journals (Sweden)

Scott Mackenzie Brockman

Full Text Available Cystic Fibrosis (CF is a genetic disorder caused by mutation(s in the CF-transmembrane conductance regulator (Cftr gene. The most common mutation, ΔF508, leads to accumulation of defective-CFTR protein in aggresome-bodies. Additionally, Pseudomonas aeruginosa (Pa, a common CF pathogen, exacerbates obstructive CF lung pathology. In the present study, we aimed to develop and test a novel strategy to improve the bioavailability and potentially achieve targeted drug delivery of cysteamine, a potent autophagy-inducing drug with anti-bacterial properties, by developing a dendrimer (PAMAM-DEN-based cysteamine analogue.We first evaluated the effect of dendrimer-based cysteamine analogue (PAMAM-DENCYS on the intrinsic autophagy response in IB3-1 cells and observed a significant reduction in Ub-RFP and LC3-GFP co-localization (aggresome-bodies by PAMAM-DENCYS treatment as compared to plain dendrimer (PAMAM-DEN control. Next, we observed that PAMAM-DENCYS treatment shows a modest rescue of ΔF508-CFTR as the C-form. Moreover, immunofluorescence microscopy of HEK-293 cells transfected with ΔF508-CFTR-GFP showed that PAMAM-DENCYS is able to rescue the misfolded-ΔF508-CFTR from aggresome-bodies by inducing its trafficking to the plasma membrane. We further verified these results by flow cytometry and observed significant (p<0.05; PAMAM-DEN vs. PAMAM-DENCYS rescue of membrane-ΔF508-CFTR with PAMAM-DENCYS treatment using non-permeabilized IB3-1 cells immunostained for CFTR. Finally, we assessed the autophagy-mediated bacterial clearance potential of PAMAM-DENCYS by treating IB3-1 cells infected with PA01-GFP, and observed a significant (p<0.01; PAMAM-DEN vs. PAMAM-DENCYS decrease in intracellular bacterial counts by immunofluorescence microscopy and flow cytometry. Also, PAMAM-DENCYS treatment significantly inhibits the growth of PA01-GFP bacteria and demonstrates potent mucolytic properties.We demonstrate here the efficacy of dendrimer-based autophagy

Autogenous shrinkage of Ducorit S5R ASTM C 1698-09 test method

DEFF Research Database (Denmark)

Damkilde, Lars

The report deals with experimental measurement of autogenous shrinkage of Ducorit S5R according to the test method ASTM C 1698-09. This test method measures the bulk strain of a sealed cementitious specimen, at constant temperature and not subjected to external forces, from the time of final...

Neutron irradiation effects on mechanical properties in SA508 Gr4N high strength low alloy steel

International Nuclear Information System (INIS)

Kim, Minchul; Lee, Kihyoung; Park, Sanggyu; Choi, Kwonjae; Lee, Bongsang

2012-01-01

The Reactor Pressure Vessel (RPV) is the key component in determining the lifetime of nuclear power plants because it is subject to the significant aging degradation by irradiation and thermal aging, and there is no practical method for replacing that component. Advanced reactors with much larger capacity than current reactor require the usage of higher strength materials inevitably. The SA508 Gr.4N Ni Cr Mo low alloy steel, in which Ni and Cr contents are larger than in conventional RPV steels, could be a promising RPV material offering improved strength and toughness from its tempered martensitic microstructure. For a structural integrity of RPV, the effect of neutron irradiation on the material property is one of the key issues. The RPV materials suffer from the significant degradation of transition properties by the irradiation embrittlement when its strength is increased by a hardening mechanism. Therefore, the potential for application of SA508 Gr.4N steel as the structural components for nuclear power reactors depends on its ability to maintain adequate transition properties against the operating neutron does. However, it is not easy to fine the data on the irradiation effect on the mechanical properties of SA508 Gr.4N steel. In this study, the irradiation embrittlement of SA508 Gr.4N Ni Cr Mo low alloy steel was evaluated by using specimens irradiated in research reactor. For comparison, the variations of mechanical properties by neutron irradiation for commercial SA508 Gr.3 Mn Mo Ni low alloy steel were also evaluated

The Status of silicosis in the world: Feedback on the ASTM Silica Symposium

CSIR Research Space (South Africa)

Pretorius, CJ

2013-06-01

Full Text Available The second ASTM Silica Symposium was held in Oct 2012 where speakers reported on the status of silicosis in their respective countries. Speakers reported on findings of research that they carried out on sampling equipment and analytical techniques...

Summary: Update to ASTM guide E 1523 to charge control and charge referencing techniques in x-ray photoelectron spectroscopy

International Nuclear Information System (INIS)

Baer, D.R.

2005-01-01

An updated version of the American Society for Testing and Materials (ASTM) guide E 1523 to the methods to charge control and charge referencing techniques in x-ray photoelectron spectroscopy has been released by ASTM [Annual Book of ASTM Standards Surface Analysis (American Society for Testing and Materials, West Conshohocken, PA, 2004), Vol. 03.06]. The guide is meant to acquaint x-ray photoelectron spectroscopy (XPS) users with the various charge control and charge referencing techniques that are and have been used in the acquisition and interpretation of XPS data from surfaces of insulating specimens. The current guide has been expanded to include new references as well as recommendations for reporting information on charge control and charge referencing. The previous version of the document had been published in 1997 [D. R. Baer and K. D. Bomben, J. Vac. Sci. Technol. A 16, 754 (1998)

Weldability examination of ASTM A 240 S41500 martensitic stainless steel by thermal cycles simulation testings

Directory of Open Access Journals (Sweden)

Alberto Velázquez-del Rosario

2015-07-01

Full Text Available The weldability assets of ASTM A 240 S41500 (ASTM A 240/A 240M martensitic stainless steel are presented through the study of the effects of single and double thermal weld cycles on mechanical properties and microstructure of base metal (BM and the artificial heat affected zone (HAZ created by thermal weld simulations. For single cycles, separate peak temperatures of 1000 ºC/12 s and 1350 ºC/12 s (cooling times: 12 s in both cases were evaluated, whilst two combinations of peak temperatures: (1350 ºC/5 s + 1000 ºC/5 s ºC and (1350 ºC/12 s + 1000 ºC/12 s ºC (cooling times: 5 s and 12 s, were applied for double cycles. Post weld heat treatment (PWHT with short and long holding times were applied and Vickers hardness, impact toughness and metallographic examinations were used in order to assess mechanical and metallographic properties in the as-simulated (no heat treated and postweld heat treated conditions. Best properties of the welded joint for double thermal weld cycles with long holding times were reached, which reveals the good weldability and applicability of the tested material in post weld heat treated conditions.

Comparing the Methodologies in ASTM G198 Using Combined Hygrothermal-Corrosion Modeling

Science.gov (United States)

Samuel L. Zelinka

2013-01-01

ASTM G198, “Standard test method for determining the relative corrosion performance of driven fasteners in contact with treated wood,” was accepted by consensus and published in 2011. The method has two different exposure conditions for determining fastener corrosion performance in treated wood. The first method places the wood and embedded fasteners in a...

The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3

Directory of Open Access Journals (Sweden)

Liping He

2012-11-01

Membrane proteins make up ∼30% of the proteome. During the early stages of maturation, this class of proteins can experience localized misfolding in distinct cellular compartments, such as the cytoplasm, endoplasmic reticulum (ER lumen and ER membrane. ER quality control (ERQC mechanisms monitor folding and determine whether a membrane protein is appropriately folded or is misfolded and warrants degradation. ERQC plays crucial roles in human diseases, such as cystic fibrosis, in which deletion of a single amino acid (F508 results in the misfolding and degradation of the cystic fibrosis transmembrane conductance regulator (CFTR Cl– channel. We introduced the ΔF508 mutation into Caenorhabditis elegans PGP-3, a 12-transmembrane ABC transporter with 15% identity to CFTR. When expressed in intestinal epithelial cells, PGP-3wt was stable and efficiently trafficked to the apical plasma membrane through a COPII-dependent mechanism. However, PGP-3ΔF508 was post-transcriptionally destabilized, resulting in reduced total and apical membrane protein levels. Genetic or physiological activation of the osmotic stress response pathway, which causes accumulation of the chemical chaperone glycerol, stabilized PGP-3ΔF508. Efficient degradation of PGP-3ΔF508 required the function of several C. elegans ER-associated degradation (ERAD homologs, suggesting that destabilization occurs through an ERAD-type mechanism. Our studies show that the ΔF508 mutation causes post-transcriptional destabilization and degradation of PGP-3 in C. elegans epithelial cells. This model, combined with the power of C. elegans genetics, provides a new opportunity to genetically dissect metazoan ERQC.

Mechanical behaviour of Astm A 297 grade Hp joints welded using different processes

International Nuclear Information System (INIS)

Emygdio, Paulo Roberto Oliveira; Zeemann, Annelise; Almeida, Luiz Henrique de

1996-01-01

The influence of different arc welding processes on mechanical behaviour was studied for cast heat resistant stainless steel welded joints, in the as welded conditions. ASTM A 297 grade HP with niobium and niobium/titanium additions were welded following three different welding procedures, using shielded metal arc welding gas tungsten arc welding and plasma arc welding, in six welded joints. The welded joint mechanical behaviour was evaluated by ambient temperature and 870 deg C tensile tests; and creep tests at 900 deg C and 50 MPa. Mechanical test results showed that the welding procedure qualification following welding codes is not suitable for high temperature service applications. (author)

Modification of ASTM Standard E1681 on Environmental Cracking to Include Bolt-Load Specimen Testing

National Research Council Canada - National Science Library

Underwood, Jean D. M

1997-01-01

Benet Laboratories experience with environmental cracking of cannon components has been combined with the technical expertise of various participants at ASTM technical meetings and symposia to develop...

Estimation of improved productivity based on materials substitution in high temperature applications. Use of alloy ASTM A-335 P91

International Nuclear Information System (INIS)

Serna, J A; Afanador, W

2001-01-01

In ECOPETROL-ICP was carried out an evaluation of the mechanical and micro structural properties of modified 9 Cr-1 Mo alloy, ASTM A-335 Gr. P91, finding higher strength mechanical properties, allowable stresses and creep rupture strength, than the conventional 9 Cr-1 Mo alloy, ASTM A-335 Gr. P9, recommending the alloy P91 as substitute tube material in the radiation zone of the Visbreaking heater of Cartagena's refinery (furnace in revamping process). The results obtained permit a thickness reduction of radiation tubes of material P91 close to 25% and increase the internal volume tube over up 8%, which is a parameter to consider in improving productivity and efficiency process. Also would be obtained a significant savings cost in the material among 5 and 10%. Additionally, expectations of both design and remaining useful life would be seen extensively favored with this change of alloy

314. Extracción de dispositivos intracardíacos en pacientes sometidos previamente a procedimientos de cardiología intervencionista

OpenAIRE

E. Villagrán; L. Montes; Z. Garcés; A. Ayaon; M. Carnero; J. Silva; A. Alswies; J.E. Rodríguez

2012-01-01

Descripción de una cohorte de pacientes sometidos a la implantación de algún dispositivo intracardíaco percutáneo (DCIP) que finalmente fueron intervenidos quirúrgicamente por disfunción de los mismos. Material y métodos: Se analizó de forma retrospectiva toda la cohorte de pacientes sometidos a extracción de DCIP intervenidos en nuestro centro. Se describe la muestra de pacientes y se resumen los resultados quirúrgicos. Resultados: Desde julio de 2007 – julio de 2011, 25 pacientes inte...

Effect of increased fuel temperature on emissions of oxides of nitrogen from a gas turbine combustor burning ASTM jet-A fuel

Science.gov (United States)

Marchionna, N. R.

1974-01-01

An annular gas turbine combustor was tested with heated ASTM Jet-A fuel to determine the effect of increased fuel temperature on the formation of oxides of nitrogen. Fuel temperature ranged from ambient to 700 K. The NOx emission index increased at a rate of 6 percent per 100 K increase in fuel temperature.

Effects of Tempering Temperature and Path on the Microstructural and Mechanical Properties of ASTM Gr.92 Steel

International Nuclear Information System (INIS)

Han, C. H.; Baek, J. H.; Kim, S. H.; Lee, C. B.; Kim, Y. K.; Hong, S. I.

2009-01-01

SFR (Sodium-Cooled Fast Reactor) is one of the prospective nuclear reactor for the next generation (Gen-IV) systems. The fuel claddings in the SFR are subject to a high fast nuclear irradiation and a high temperature. Fuel technology is a key aspect of an SFR system, with implications for reactor safety, reactor operations, fuel reprocessing technology, and overall system economics. ASTM Gr.92 steel has been considered as the one of the main candidate fuel cladding materials in the design of SFR in that it has higher thermal conductivity as well as dimensional stability under irradiation when compared as austenitic stainless steel. The changes in microstructure and heat-treatment varying M 23 C 6 , MX, M 2 X, and precipitation by ASTM Gr.92 steels to improve high temperature mechanical properties is the attention. According to several researchers, it plays an important role in the mechanical properties of precipitates V, Nb, Cr, C, N as a form of MX and M 2 X precipitates. These fine precipitates formed in the sub- grain by preventing the movement of dislocations in high-temperature mechanical properties will contribute effectively. This study investigated the effects of tempering temperature and heat-treatment path on microstructure and mechanical properties of ASTM Gr.92 steels

Transient absorption spectroscopy in biology using the Super-ACO storage ring FEL and the synchrotron radiation combination

International Nuclear Information System (INIS)

Renault, Eric; Nahon, Laurent; Garzella, David; Nutarelli, Daniele; De Ninno, Giovanni; Hirsch, Matthias; Couprie, Marie Emmanuelle

2001-01-01

The Super-ACO storage ring FEL, covering the UV range down to 300 nm with a high average power (300 mW at 350 nm) together with a high stability and long lifetime, is a unique tool for the performance of users applications. We present here the first pump-probe two color experiments on biological species using a storage ring FEL coupled to the synchrotron radiation. The intense UV pulse of the Super-ACO FEL is used to prepare a high initial concentration of chromophores in their first singlet electronic excited state. The nearby bending magnet synchrotron radiation provides, on the other hand a pulsed, white light continuum (UV-IR), naturally synchronized with the FEL pulses and used to probe the photochemical subsequent events and the associated transient species. We have demonstrated the feasibility with a dye molecule (POPOP) observing a two-color effect, signature of excited state absorption and a temporal signature with Acridine. Applications on various chromophores of biological interest are carried out, such as the time-resolved absorption study of the first excited state of Acridine

Mensuração do tamanho cardíaco em radiografias de gatos com hipertireoidismo experimental

Directory of Open Access Journals (Sweden)

Mauro José Lahm Cardoso

2007-04-01

Full Text Available O hipertireoidismo felino ou tireotoxicose é a doença endócrina mais freqüente em gatos domésticos. O hipertireoidismo felino é uma desordem multissistêmica associada com aumento das concentrações dos hormônios tireoidianos circulantes, triidotironina (T3 e tiroxina (T4. Anormalidades cardiovasculares em gatos com hipertireoidismo espontâneo já foram bem descritas. O objetivo deste trabalho foi realizar a mensuração cardíaca em 19 gatos submetidos a tireotoxicose experimental, utilizando o "vertebral heart size" (VHS. A mensuração utilizando o VHS foi realizada a partir de radiografias torácicas lateral, dorsoventral e ventrodorsal. As radiografias torácicas laterais foram mais eficazes do que as ventrodorsal e dorsoventral em ilustrar o aumento progressivo do coração. O VHS é um método fácil de ser usado, permitindo a avaliação do tamanho cardíaco em gatos hipertireóideos, e facilita a identificação de cardiomegalia e progressão do tamanho cardíaco.

Manejo de las dislipidemias en pacientes cardíacos trasplantados. Hallazgos sobre nuevos factores de riesgo

Directory of Open Access Journals (Sweden)

Walter Masson

2008-01-01

Full Text Available En pacientes cardíacos trasplantados, el desarrollo de enfermedad vascular coronaria es una complicación frecuente y la dislipidemia es uno de los predictores más importantes. Los inmunosupresores predisponen a las dislipidemias y dificultan la utilización de hipolipemiantes. En este grupo particular de pacientes se recomienda alcanzar las metas terapéuticas de prevención secundaria. Las estatinas son los hipolipemiantes de elección. No existen recomendaciones claras sobre nuevos factores de riesgo, como la homocisteína y la lipoproteína (a [Lp(a].Con el objetivo de conocer el perfil lipídico, la prevalencia de homocisteinemia y de Lp(a elevadas, el cumplimiento de las metas terapéuticas y la tolerancia a la medicación, se incluyeron en el estudio 23 pacientes cardíacos trasplantados. Los resultados mostraron que el cumplimiento de las metas lipídicas fue aceptable y que el 65% recibía tratamiento hipolipemiante. El uso de estatinas fue seguro. Se encontró una prevalencia alta de homocisteína y Lp(a elevadas. Su implicación en la modificación del tratamiento se desconoce.

ASTM STANDARD GUIDE FOR EVALUATING DISPOSAL OPTIONS FOR REUSE OF CONCRETE FROM NUCLEAR FACILITY DECOMMISSIONING

International Nuclear Information System (INIS)

Phillips, Ann Marie; Meservey, Richard H.

2003-01-01

Within the nuclear industry, many contaminated facilities that require decommissioning contain huge volumes of concrete. This concrete is generally disposed of as low-level waste at a high cost. Much of the concrete is lightly contaminated and could be reused as roadbed, fill material, or aggregate for new concrete, thus saving millions of dollars. However, because of the possibility of volumetric contamination and the lack of a method to evaluate the risks and costs of reusing concrete, reuse is rarely considered. To address this problem, Argonne National Laboratory-East (ANL-E) and the Idaho National Engineering and Environmental Laboratory teamed to write a ''concrete protocol'' to help evaluate the ramifications of reusing concrete within the U.S. Department of Energy (DOE). This document, titled the Protocol for Development of Authorized Release Limits for Concrete at U.S. Department of Energy Site (1) is based on ANL-E's previously developed scrap metal recycle protocols; on the 10-step method outlined in DOE's draft handbook, Controlling Release for Reuse or Recycle of Property Containing Residual Radioactive Material (2); and on DOE Order 4500.5, Radiation Protection of the Public and the Environment (3). The DOE concrete protocol was the basis for the ASTM Standard Guide for Evaluating Disposal Options for Concrete from Nuclear Facility Decommissioning, which was written to make the information available to a wider audience outside DOE. The resulting ASTM Standard Guide is a more concise version that can be used by the nuclear industry worldwide to evaluate the risks and costs of reusing concrete from nuclear facility decommissioning. The bulk of the ASTM Standard Guide focuses on evaluating the dose and cost for each disposal option. The user calculates these from the detailed formulas and tabulated data provided, then compares the dose and cost for each disposal option to select the best option that meets regulatory requirements. With this information

Results of ASTM round robin testing for mode 1 interlaminar fracture toughness of composite materials

Science.gov (United States)

Obrien, T. Kevin; Martin, Roderick H.

1992-01-01

The results are summarized of several interlaboratory 'round robin' test programs for measuring the mode 1 interlaminar fracture toughness of advanced fiber reinforced composite materials. Double Cantilever Beam (DCB) tests were conducted by participants in ASTM committee D30 on High Modulus Fibers and their Composites and by representatives of the European Group on Fracture (EGF) and the Japanese Industrial Standards Group (JIS). DCB tests were performed on three AS4 carbon fiber reinforced composite materials: AS4/3501-6 with a brittle epoxy matrix; AS4/BP907 with a tough epoxy matrix; and AS4/PEEK with a tough thermoplastic matrix. Difficulties encountered in manufacturing panels, as well as conducting the tests are discussed. Critical issues that developed during the course of the testing are highlighted. Results of the round robin testing used to determine the precision of the ASTM DCB test standard are summarized.

Interacciones entre dispositivos cardíacos implantables y modalidades fisioterapéuticas: ¿Mito o realidad?

Directory of Open Access Journals (Sweden)

Genevieve C. Digby

2011-04-01

Full Text Available La fisioterapia se ha transformado en una especialidad que claramente incide en la calidad de vida de nuestros pacientes. En poblaciones añosas, el uso de fisioterapia incluye múltiples modalidades para un alto número de distintas enfermedades. Varios informes sobre posibles interacciones negativas entre las distintas modalidades de fisioterapia y los dispositivos cardíacos implantables (marcapasos y cardiodesfibriladores han sido publicados en los últimos aňos. A pesar de ello, existe muy poca evidencia y guías precisas para identificar cuáles son las modalidades de fisioterapia seguras a utilizar en esta población de pacientes. En la siguiente revisión, nos propusimos resumir las interacciones documentadas entre fisioterapia y dispositivos cardíacos implantables (DCI, discutir el estándar actual de estas prácticas e identificar las principales consideraciones que existen desde la perspectiva de un servicio de electrofisiología cardíaca, para el tratamiento adecuado en estos pacientes. Finalmente, abogamos por fortalecer la colaboración entre fisioterapeutas y electrofisiólogos, con el fin de asegurar una óptima y segura atención de este grupo de pacientes.

Effects of the normalizing time and temperature on the impact properties of ASTM A-516 grade 70 steel

International Nuclear Information System (INIS)

Carneiro, T.; Cescon, T.

1982-01-01

The influence of normalizing time and temperature, as well as the plate thickness, on the impact properties of ASTM A-516 grade 70 steel, is studied. Results show that different normalizing conditions may lead to equivalent microstructure with different impact properties. Normalizing conditions that cause low cooling rate in the critical zone exhibit banded microstructure with inferior impact properties. (Author) [pt

Doctors on deck. ACOs led by doctors seek to manage costs, quality and hospital relationships.

Science.gov (United States)

Evans, Melanie

2012-04-16

Most of the first crop of ACOs in the Medicare Shared Savings Program are owned and operated by physicians without formal participation of a hospital in the efforts to improve quality and curb costs. "There were some people who feared that the only entities that would participate would be hospital-dominated systems," says Jonathan Blum, director of the Center for Medicare Management at the CMS, left. "That has not happened".

Tests were inconclusive: California's experiment with ACOs raises questions about whether they'll save money.

Science.gov (United States)

Vesely, Rebecca

2010-11-01

In California, many providers have been working in accountable care organizations for decades, and they say they can work well. "It's not the type of organization that defines the success of an ACO, it's the leadership," said Tom Williams, executive director of the Oakland, Calif.-based Integrated Healthcare Association. "For success, there needs to be alignment between hospitals and physicians."

Biocompatibility of metal injection molded versus wrought ASTM F562 (MP35N) and ASTM F1537 (CCM) cobalt alloys.

Science.gov (United States)

Chen, Hao; Sago, Alan; West, Shari; Farina, Jeff; Eckert, John; Broadley, Mark

2011-01-01

We present a comparative analysis between biocompatibility test results of wrought and Metal Injection Molded (MIM) ASTM F562-02 UNS R30035 (MP35N) and F1537 UNS R31538 (CCM) alloy samples that have undergone the same generic orthopedic implant's mechanical, chemical surface pre-treatment, and a designed pre-testing sample preparation method. Because the biocompatibility properties resulting from this new MIM cobalt alloy process are not well understood, we conducted tests to evaluate cytotoxicity (in vitro), hemolysis (in vitro), toxicity effects (in vivo), tissue irritation level (in vivo), and pyrogenicity count (in vitro) on such samples. We show that our developed MIM MP35N and CCM materials and treatment processes are biocompatible, and that both the MIM and wrought samples, although somewhat different in microstructure and surface, do not show significant differences in biocompatibility.

Comparing the Methodologies in ASTM G198: Is There an Easy Way Out?

Science.gov (United States)

Samuel L. Zelinka

2013-01-01

ASTM(1) G198, Standard test method for determining the relative corrosion performance of driven fasteners in contact with treated wood, was accepted by consensus and published in 2011. The method has two different exposure conditions for determining fastener corrosion performance in treated wood. The first method places the wood and embedded...

Experimental and numerical study of a modified ASTM C633 adhesion test for strongly-bonded coatings

Energy Technology Data Exchange (ETDEWEB)

Bernardie, Raphaëlle; Berkouch, Reda; Valette, Stéphane; Absi, Joseph; Lefort, Pierre [University of Limoges, Limoges Cedex (France)

2017-07-15

When coatings are strongly bonded to their substrates it is often difficult to measure the adhesion values. The proposed method, which is suggested naming “silver print test”, consists in covering the central part of the samples with a thin layer of silver paint, before coating. The process used for testing this new method was the Air plasma spraying (APS), and the materials used were alumina coatings on C35 steel substrates, previously pre-oxidized in CO{sub 2}. The silver painted area was composed of small grains that did not oxidize but that significantly sintered during the APS process. The silver layer reduced the surface where the coating was linked to the substrate, which allowed its debonding, using the classical adhesion test ASTM C633-13, while the direct use of this test (without silver painting) led to ruptures inside the glue used in this test. The numerical modelling, based on the finite element method with the ABAQUS software, provided results in good agreement with the experimental measurements. This concordance validated the used method and allowed accessing to the values of adherence when the experimental test ASTM C633-13 failed, because of ruptures in the glue. After standardization, the “silver print test” might be used for other kinds of deposition methods, such as PVD, CVD, PECVD.

Síndrome de bajo gasto cardíaco en la tetralogía de Fallot

Directory of Open Access Journals (Sweden)

Lincoln de la Parte Pérez

2002-06-01

Full Text Available Se realiza un estudio retrospectivo de 200 niños operados de tetralogía de Fallot en el Cardiocentro del Hospital Pediátrico Universitario "William Soler" durante el período comprendido entre los años 1990 y 1993. Se observó una relación directamente proporcional entre el tiempo de pinzamiento aórtico (paro anóxico, el tiempo de circulación extracorpórea (CEC y el desarrollo del síndrome de bajo gasto cardíaco. La incidencia de bajo gasto cardíaco en los niños con tiempo de pinzamiento aórtico menor a los 30 min fue nula, en los pacientes con tiempo menor a los 60 min la incidencia fue del 23,2 % (40 pacientes. En los 24 pacientes que sufrieron procedimientos quirúrgicos prolongados y tiempo de pinzamiento aórtico mayor de 1 hora la incidencia fue del 95,8 %. En los pacientes con tiempo de CEC menor de 90 min la incidencia de bajo gasto cardíaco que de sólo el 9,75 %, en los niños con tiempo de CEC entre 91 y 105 min fue de 15,53 %, en los que necesitaron entre 106 y 120 min de CEC fue del 62,5 % y en los procedimientos quirúrgicos prolongados fue del 95,8 %. La mayoría de los pacientes respondió bien al tratamiento, aunque en un pequeño número de ellos se mantuvo la disfunción ventricular a pesar del tratamiento. Siete niños fallecieron en el posoperatorio para una mortalidad del 3,5 %.A retrospective study of 200 children with Tetralogy of Fallot, who were operated on the Cardiology Center of "William Soler" University Pediatric Hospital from 1990 to 1993, was performed. There was a direct proportional relation between time of holding aorta with forceps (anoxic arrest, time of extracorporeal circulation and the development of low cardiac output syndrome. The incidence of low cardiac output in children who underwent holding of aorta with forceps for less than 30 minutes was zero, but the same procedure applied in patients for less than 60 minutes, the incidence was 23,2%(40 patients. The 24 patients that underwent

“Manifestos do Coração”: Significados Atribuídos à Doença por Pacientes Cardíacos Pré-cirúrgicos

Directory of Open Access Journals (Sweden)

Shana Hastenpflug Wottrich

Full Text Available RESUMOEste estudo objetivou explorar os significados atribuídos à doença cardíaca por pacientes cardíacos pré-cirúrgicos em tratamento ambulatorial no sul do Brasil. É um estudo clínico-qualitativo, de caráter exploratório e descritivo, cuja coleta de dados aconteceu por meio de entrevistas semiestruturadas e da autofotografia, propostas a 15 indivíduos. Foi realizada análise de conteúdo temática, emergindo as categorias: Confrontação com a doença: os saberes em questão, Negação da doença, Doença e trabalho e Sexualidade rompida. Os resultados destacaram as dificuldades dos participantes relacionadas à apropriação do quadro da doença e à aceitação dessa condição. Salienta-se a premência de ações de saúde, que possam ser coadjuvantes na reestruturação das possibilidades de vida para os pacientes cardíacos pré-cirúrgicos.

Comparative Study of API 5L X60 and ASTM 572 Gr50 Steel Exposed to Crude Oil and Seawater

Directory of Open Access Journals (Sweden)

Marcy Viviana Chiquillo Márquez

2018-04-01

Full Text Available In the petroleum industry, the biphasic conditions in storage and separation tanks allow that the material to remain exposed to two different environments, causing its deterioration. In this article, an evaluation is made of the corrosive behavior and Vickers microhardness (HV of two high strength low alloy (HSLA steels and how their surfaces are characterized. The ASTM 572 Gr50 steel showed a lower corrosion rate in all systems after being immersed for 720 and 1440 hours. Characterizing the surface by means of Scanning Electron Microscopy (SEM showed uniform and localized corrosion for the both steels, and revealed that the ASTM 572 Gr50 steel shows pitting corrosion in crude oil systems. The electrochemical results revealed that the corrosion potential of API X60 steel was more negative; however the ASTM 572 Gr50 steel had a higher current density and a lower polarization resistance when immersed in an oil/seawater mixture. It also observed that, after being immersed in the corrosive fluids, the microstructures of the steels were not modified and variations in their microhardness (HV were minute.

Standard specification for tantalum and tantalum alloy plate, sheet, and strip. ASTM standard

International Nuclear Information System (INIS)

1998-09-01

This specification is under the jurisdiction of ASTM Committee B-10 on Reactive and Refractory Metals and Alloys and is the direct responsibility of Subcommittee B10.03 on Niobium and Tantalum. Current edition approved May 10, 1998 and published September 1998. Originally published as B 708-82. Last previous edition was B 708-92

Multi-criteria ACO-based Algorithm for Ship’s Trajectory Planning

Directory of Open Access Journals (Sweden)

Agnieszka Lazarowska

2017-03-01

Full Text Available The paper presents a new approach for solving a path planning problem for ships in the environment with static and dynamic obstacles. The algorithm utilizes a heuristic method, classified to the group of Swarm Intelligence approaches, called the Ant Colony Optimization. The method is inspired by a collective behaviour of ant colonies. A group of agents - artificial ants searches through the solution space in order to find a safe, optimal trajectory for a ship. The problem is considered as a multi-criteria optimization task. The criteria taken into account during problem solving are: path safety, path length, the International Regulations for Preventing Collisions at Sea (COLREGs compliance and path smoothness. The paper includes the description of the new multi-criteria ACO-based algorithm along with the presentation and discussion of simulation tests results.

Microstructure and mechanical characteristics of a laser welded joint in SA508 nuclear pressure vessel steel

Energy Technology Data Exchange (ETDEWEB)

Guo, Wei, E-mail: wei.guo-2@manchester.ac.uk [Laser Processing Research Centre, School of Mechanical, Aerospace and Civil Engineering, University of Manchester, Sackville Street, Manchester, M13 9 PL (United Kingdom); Dong, Shiyun [Laser Processing Research Centre, School of Mechanical, Aerospace and Civil Engineering, University of Manchester, Sackville Street, Manchester, M13 9 PL (United Kingdom); Institute of Laser Engineering, Beijing University of Technology, Beijing 100124 (China); Guo, Wei; Francis, John A.; Li, Lin [Laser Processing Research Centre, School of Mechanical, Aerospace and Civil Engineering, University of Manchester, Sackville Street, Manchester, M13 9 PL (United Kingdom)

2015-02-11

SA508 steels are typically used in civil nuclear reactors for critical components such as the reactor pressure vessel. Nuclear components are commonly joined using arc welding processes, but with design lives for prospective new build projects exceeding 60 years, new welding technologies are being sought. In this exploratory study, for the first time, autogenous laser welding was carried out on 6 mm thick SA508 Cl.3 steel sheets using a 16 kW fiber laser system operating at a power of 4 kW. The microstructure and mechanical properties (including microhardness, tensile strength, elongation, and Charpy impact toughness) were characterized and the microstructures were compared with those produced through arc welding. A three-dimensional transient model based on a moving volumetric heat source model was also developed to simulate the laser welding thermal cycles in order to estimate the cooling rates included by the process. Preliminary results suggest that the laser welding process can produce welds that are free of macroscopic defects, while the strength and toughness of the laser welded joint in this study matched the values that were obtained for the parent material in the as-welded condition.

Strain ageing of nuclear pressure vessel steels A533B and A508 cl.2

International Nuclear Information System (INIS)

Pelli, R.; Toerroenen, K.

1978-04-01

The susceptibility of the reactor pressure vessel steels A533B and A508 cl.2 to strain ageing has been studied using conventional tensile and impact testing of prestrained and aged specimens. The results show a modest susceptibility, seen as an increase in yield strength and Charpy V transition temperatures. The effect of varying alloying additions within the range of normal production was not observed, but the initial mechanical properties clearly affect the strain ageing. The lower the initial yield strength, the higher increase in strength and the lower increase in transition temperature is observed. (author)

Analysis and evaluation of the Electronic Health Record standard in China: a comparison with the American national standard ASTM E 1384.

Science.gov (United States)

Xu, Wei; Guan, Zhiyu; Cao, Hongxin; Zhang, Haiyan; Lu, Min; Li, Tiejun

2011-08-01

To analyze and evaluate the newly issued Electronic Health Record (EHR) Architecture and Data Standard of China (Chinese EHR Standard) and identify areas of improvement for future revisions. We compared the Chinese EHR Standard with the standard of the American Society for Testing and Materials Standard Practice for Content and Structure of Electronic Health Records in the United States (ASTM E 1384 Standard). The comparison comprised two steps: (1) comparing the conformance of the two standards to the international standard: Health Informatics-Requirements for an Electronic Health Record Architecture (ISO/TS 18308), and showing how the architectures of the two standards satisfy or deviate from the ISO requirements and (2) comparing the detailed data structures between the two standards. Of the 124 requirement items in ISO/TS 18308, the Chinese EHR Standard and the ASTM E 1384 Standard conformed to 77 (62.1%) and 111 (89.5%), respectively. The Chinese EHR Standard conformed to 34 of 50 Structure requirements (68.0%), 22 of 24 Process requirements (91.7%), and 21 of 50 Other requirements (42.0%). The ASTM E 1384 Standard conformed to 49 of 50 Structure requirements (98.0%), 23 of 24 Process requirements (95.8%), and 39 of 40 Other requirements (78.0%). Further development of the Chinese EHR Standard should focus on supporting privacy and security mechanism, diverse data types, more generic and extensible lower level data structures, and relational attributes for data elements. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Quantificação de tecido conjuntivo do músculo cardíaco de cães

Directory of Open Access Journals (Sweden)

Hildebrando Gomes Benedicto

2003-01-01

Full Text Available Objetivou-se, neste trabalho, estudar a proporção de tecido conjuntivo existente na fração ventricular direita e esquerda do músculo cardíaco de cães, buscando, através da morfometria, dados referentes a inter-relação entre o tecido conjuntivo e o tecido muscular cardíaco, para o conhecimento das relações anátomo-funcionais da estrutura cardíaca, característica de determinados processos ligados a diminuição do trabalho do órgão. Utilizou-se 6 corações de cães SRD, machos e fêmeas, com idade entre 48 e 150 meses, pesando entre 18 e 30 Kg, sem alterações cardíacas, confirmado mediante exames eletrocardiográfico e ecocardiográfico. Preparou-se o material oriundo de três regiões ventriculares em relação a sua base, proximal, média e distal, tanto da face direita quanto da esquerda, segundo as técnicas histológicas convencionais e corados com Picrosirius red, Fucsina-Paraldeido e Tricromo de Gomori, para evidenciação das fibras conjuntivas. As lâminas foram analisadas com auxílio do Axioscópio Zeiss acoplado ao programa de análise de imagens KS-400 Zeiss. A quantidade de tecido conjuntivo no Ventrículo Esquerdo variou de 0,44 a 26,26%; no Ventrículo Direito variou de 0,97 a 21,18%; no ápice variou de 1,32 a 29,24% e no septo interventricular variou de 5,41 a 11,24%. Os resultados obtidos mostram que há uma complexa rede de fibras conjuntivas envolvendo as fibras do tecido muscular cardíaco e que sua quantidade e disposição é muito variada, dependendo da região estudada.

Dynamics and performance of the free electron laser at Super-Aco with a harmonic RF cavity set on 500 MHz

International Nuclear Information System (INIS)

Nutarelli, D.

2000-01-01

This work is dedicated to the development of the potentialities of the free electron laser that has been installed on the storage ring Super-Aco at Orsay university. We have studied the dynamics of the electron beam inside a harmonic RF cavity set on 500 MHz. The impact of the geometric characteristics of the optical cavity on the transverse overlapping between laser radiation and the electron beam has been studied in details. An important part of the work has been the assessment of the optical characterization of the dielectric multi-layer mirrors of the cavity. For that purpose a complete system has been designed to assess the changes in optical properties of mirrors during laser operation. Another important part of this work was the study of the interaction process between laser radiation and the electron bunch leading to saturation. This interaction process has been simulated through a new model and some predictions given by this model have been successfully confronted to experimental data. The installation of the harmonic RF cavity has led to a significant increase of the laser radiation gain and the value of the mean power of the laser radiation has reached 300 mW. An interesting application of this technique is the generation of high energy gamma photons through Compton backscattering. A collimated 35 MeV-energy photon beam has been produced at Super-Aco with a rate of 5.10 6 photons per second. (A.C.)

Hot Deformation Behavior of SA508Gr.4N Steel for Reactor Pressure Vessels

Directory of Open Access Journals (Sweden)

YANG Zhi-qiang

2017-08-01

Full Text Available The high-temperature plastic deformation and dynamic recrystallization behavior of SA508Gr.4N steel were investigated through hot deformation tests in a Gleeble1500D thermal mechanical simulator. The compression tests were performed in the temperature range of 1050-1250℃ and the strain rate range of 0.001-0.1s-1 with true strain of 0.16. The results show that from the high-temperature true stress-strain curves of the SA508Gr.4N steel, the main feature is dynamic recrystallization,and the peak stress increases with the decrease of deformation temperature or the increase of strain rate, indicating the experimental steel is temperature and strain rate sensitive material. The constitutive equation for SA508Gr.4N steel is established on the basis of the true stress-strain curves, and exhibits the characteristics of the high-temperature flow behavior quite well, while the activation energy of the steel is determined to be 383.862kJ/mol. Furthermore, an inflection point is found in the θ-σ curve, while the -dθ/dσ-σ curve shows a minimum value. The critical strain increases with increasing strain rate and decreasing deformation temperature. A linear relationship between critical strain (εc and peak strain (εp is found and could be expressed as εc/εp=0.517. The predicted model of critical strain could be described as εc=8.57×10-4Z0.148.

Relation between the national handbook of recommended methods for water data acquisition and ASTM standards

Science.gov (United States)

Glysson, G. Douglas; Skinner, John V.

1991-01-01

In the late 1950's, intense demands for water and growing concerns about declines in the quality of water generated the need for more water-resources data. About thirty Federal agencies, hundreds of State, county and local agencies, and many private organizations had been collecting water data. However, because of differences in procedures and equipment, many of the data bases were incompatible. In 1964, as a step toward establishing more uniformity, the Bureau of the Budget (now the Office of Management and Budget, OMB) issued 'Circular A-67' which presented guidelines for collecting water data and also served as a catalyst for creating the Office of Water Data Coordination (OWDC) within the U.S. Geological Survey. This paper discusses past, present, and future aspects of the relation between methods in the National Handbook and standards published by ASTM (American Society for Testing and Materials) Committee D-19 on Water's Subcommittee D-19.07 on Sediment, Geomorphology, and Open Channel Flow. The discussion also covers historical aspects of standards - development work jointly conducted by OWDC and ASTM.

Heat treatment evaluation of steel ASTM A-131 grade A by X-Ray diffraction

Energy Technology Data Exchange (ETDEWEB)

Ferreira Junior, Francisco; Feio, Luciana Gaspar; Costa, Ednelson Silva; Rodrigues, Lino Alberto Soares; Braga, Eduardo Magalhaes, E-mail: juniorferrer93@gmail.com [Universidade Federal do Pará (UFPA), Belém, PA (Brazil)

2016-07-01

Full text: This study evaluates the residual stress of naval steel ASTM A-131 grade A before and after heat treatment. Residual stresses were determined by the technique of X-ray diffraction (XRD). Before heat treatment the residual stress measurements were made at 36 (thirty six) points distributed in a specimen with dimensions of 400 mm long, 200 mm wide and 95 mm thick, then the plate under analysis was brought to the oven for the implementation of heat treatment. To check the performance of the heat treatment, the plate was again subjected to XRD measurements of the same points previously measured in order to compare the residual stresses. As result, there was a reduction of residual stresses with the application of heat treatment. References: [1] COLPAERT, H. Metalografia dos Produtos Siderurgicos Comuns. 4 Edição. Editora Blucher. Saõ Paulo, SP, 2008. [2] HILL, R. Princípios de Metalurgia Física, 1992. (author)

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels.

Science.gov (United States)

Marcet, Brice; Becq, Frédéric; Norez, Caroline; Delmas, Patrick; Verrier, Bernard

2004-03-01

1. Cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel is defective during cystic fibrosis (CF). Activators of the CFTR Cl(-) channel may be useful for therapy of CF. Here, we demonstrate that a range of general anesthetics like normal-alkanols (n-alkanols) and related compounds can stimulate the Cl(-) channel activity of wild-type CFTR and delF508-CFTR mutant. 2. The effects of n-alkanols like octanol on CFTR activity were measured by iodide ((125)I) efflux and patch-clamp techniques on three distinct cellular models: (1). CFTR-expressing Chinese hamster ovary cells, (2). human airway Calu-3 epithelial cells and (3). human airway JME/CF15 epithelial cells which express the delF508-CFTR mutant. 3. Our data show for the first time that n-alkanols activate both wild-type CFTR and delF508-CFTR mutant. Octanol stimulated (125)I efflux in a dose-dependent manner in CFTR-expressing cells (wild-type and delF508) but not in cell lines lacking CFTR. (125)I efflux and Cl(-) currents induced by octanol were blocked by glibenclamide but insensitive to 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid, as expected for a CFTR Cl(-) current. 4. CFTR activation by octanol was neither due to cell-to-cell uncoupling properties of octanol nor to an intracellular cAMP increase. CFTR activation by octanol requires phosphorylation by protein kinase-A (PKA) since it was prevented by H-89, a PKA inhibitor. 5. n-Alkanols chain length was an important determinant for channel activation, with rank order of potencies: 1-heptanoloctanoloctanol<1-decanol. Our findings may be of valuable interest for developing novel therapeutic strategies for CF.

Effect of using the double layer technique on the microstructure, microhardness and residual stress of welded ASTM A516 GR70 structural steel

International Nuclear Information System (INIS)

Oliveira, George Luiz Gomes de; Miranda, Helio Cordeiro de

2010-01-01

The aim of this work is to evaluate the effect of using the double layer technique on the microstructure, microhardness and residual stresses of welded ASTM A516 Gr70 structural steel. Samples were welded with the same welding parameters and two types of chamfers, while the samples welded using the double layer technique underwent a buttering process on their chamfer face. Residual stress measurement was accomplished through x-ray diffraction, using a mini diffractometer for measurement in field. Metallographic analysis was accomplished in the transverse section of the welded joint, using optic microscopy and scanning electron microscopy. The double layer technique showed that can be used in the welding of ASTM A516 Gr70 steel, because, besides promote a refinement and a drawing back of the CG-HAZ, it increased compressive residual stress in the whole surface of the analyzed samples.(author)

Imunodepressão induzida por talidomida e ciclosporina em transplante cardíaco heterotópico de coelho

Directory of Open Access Journals (Sweden)

João Batista Vieira de Carvalho

Full Text Available OBJETIVO: A talidomida, por seus efeitos antiinflamatórios e imunodepressores, tem sido utilizada no tratamento de doenças dermatológicas e na doença enxerto-contra-hospedeiro no transplante de medula óssea. O objetivo deste trabalho é avaliar a ação deste medicamento como imunodepressor em transplante de órgãos, estudando sua ação isoladamente ou em combinação com a ciclosporina na prevenção da rejeição ao aloenxerto cardíaco heterotópico em coelho. MÉTODO: Foram utilizados 50 coelhos, sendo 25 doadores e 25 receptores.Os animais receptores foram subdivididos em cinco grupos (n= 5 : Grupo I (controle animais não-imunodeprimidos; Grupo II (imunodeprimidos com ciclosporina na dose de 10 mg/kg/dia; Grupo III (imunodeprimidos com talidomida na dose de 100 mg/kg/dia; Grupo IV (imunodeprimidos com ciclosporina na dose de 5,0 mg/kg/dia e Grupo V (imunodeprimidos com ciclosporina na dose de 5,0 mg/kg/dia associada a talidomida na dose de 50 mg/kg/dia. Os medicamentos foram administrados através de cateter orogástrico, a partir do dia anterior ao transplante. RESULTADOS: O coração do doador foi implantado no abdome dos receptores. A associação de talidomida e ciclosporina apresentou o menor escore histopatológico de rejeição (p < 0,05. Observou-se que a talidomida empregada isoladamente ou associada à ciclosporina foi efetiva contra a rejeição, aumentando a sobrevida (p < 0,01 de animais submetidos ao transplante cardíaco heterotópico em posição abdominal. CONCLUSÕES: A talidomida empregada isoladamente, ou associada à ciclosporina, pode representar uma opção de imunodepressão em transplantes cardíaco heterotópico experimental de coelho.

Systematic Approach to Design Tailor Made Fuel Blends That Meets ASTM Standards

DEFF Research Database (Denmark)

Intikhab, S.; Kalakul, Sawitree; H., Choudhury

2015-01-01

point, vapor pressure, and heat content were determined using analytical instruments according to their respective American Society for Testing and Materials (ASTM) standards. Most of the properties complied well with the industry standards. However, model gasoline had a comparatively low RVP....... On the other hand, model diesel had a significantly higher cloud point and pour point than what is recommended. This deviation will have an impact on the cold flow properties of the fuels. For both fuels, different additives along with their composition have also been determined using the same computational...

Comparação entre a medida contínua do débito cardíaco e por termodiluição em bolus durante a revascularização miocárdica sem circulação extracorpórea

Directory of Open Access Journals (Sweden)

Kim Sílvia M.

2004-01-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: A cirurgia de revascularização miocárdica sem o uso de circulação extracorpórea (CEC relaciona-se a importantes alterações hemodinâmicas bruscas, que podem não ser prontamente detectadas pela medida contínua de débito cardíaco. Este estudo compara resultados obtidos pela medida do índice cardíaco com o cateter de artéria pulmonar com filamento térmico (Baxter Edwards Critical Care, Irvine, CA com o método padrão por termodiluição com solução, durante a anastomose coronariana distal. MÉTODO: Dez pacientes submetidos à cirurgia de revascularização miocárdica sem CEC foram monitorizados com o cateter de artéria pulmonar com filamento térmico. As medidas de índice cardíaco foram obtidas em quatro momentos: no início da anestesia, enquanto o tórax ainda estava fechado (M1, após a esternotomia (M2, após a estabilização do coração com o aparelho octopus (M3 e ao final da anastomose coronariana distal (M4. RESULTADOS: Houve diminuição significativa (p < 0,05 do índice cardíaco durante a anastomose coronariana, detectada pela medida com termodiluição com bolus de solução. O índice cardíaco variou de 2,8 ± 0,7 para 2,3 ± 0,8 l.min.m-2 no início da anastomose e 2,5 ± 0,8 l.min.m-2 ao final da mesma. Essa variação não foi detectada pela medida contínua (de 3 ± 0,6 para 3,2 ± 0,5 e 3,1 ± 0,6 l.min.m-2 durante a anastomose coronariana. CONCLUSÕES: A medida de débito cardíaco contínuo utilizando o cateter de artéria pulmonar com filamento térmico apresentou atraso na detecção das alterações hemodinâmicas agudas relacionadas à mudança do posicionamento do coração na cirurgia de revascularização miocárdica sem CEC.

Investigating fractional exhaled nitric oxide (FeNO) in chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO): a scoping review protocol.

Science.gov (United States)

Mostafavi-Pour-Manshadi, Seyed-Mohammad-Yousof; Naderi, Nafiseh; Barrecheguren, Miriam; Dehghan, Abolfazl; Bourbeau, Jean

2017-12-21

During the last decade, many articles have been published, including reviews on fractional exhaled nitric oxide (FeNO) use and utility in clinical practice and for monitoring and identifying eosinophilic airway inflammation, especially in asthma, and evaluating corticosteroid responsiveness. However, the exact role of FeNO in patients with chronic obstructive pulmonary disease (COPD) and its ability to distinguish patients with COPD and those having concomitant asthma, that is, asthma-COPD overlap (ACO) is still unclear and needs to be defined. Due to the broad topics of FeNO in chronic airway disease, we undertook a scoping review. The present article describes the protocol of a scoping review of peer-reviewed published literature specific to FeNO in COPD/ACO over the last decade. We used Joanna Briggs Institute Reviewers' Manual scoping review methodology as well as Levac et al 's and Arksey et al 's framework as guides. We searched a variety of databases, including Medline, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library, Web of Science, and BioSciences Information Service (BIOSIS) on 29 June 2016. Additional studies will be recognised by exploring the reference list of identified eligible studies. Screening of eligible studies will be independently performed by two reviewers and any disagreement will be solved by the third reviewer. We will analyse the gathered data from article bibliographies and abstracts. To investigate the body of published studies regarding the role of FeNO in patients with COPD and its usefulness in the clinical setting, a scoping review can be used as a modern and pioneer model, which does not need ethics approval. By this review, new insights for conducting new research specific to FeNO in COPD/ACO population will emerge. The results of this study will be reported in the scientific meetings and conferences, which aim to provide information to the clinicians, primary care providers and basic

Interpreting the ASTM 'content standard for digital geospatial metadata'

Science.gov (United States)

Nebert, Douglas D.

1996-01-01

ASTM and the Federal Geographic Data Committee have developed a content standard for spatial metadata to facilitate documentation, discovery, and retrieval of digital spatial data using vendor-independent terminology. Spatial metadata elements are identifiable quality and content characteristics of a data set that can be tied to a geographic location or area. Several Office of Management and Budget Circulars and initiatives have been issued that specify improved cataloguing of and accessibility to federal data holdings. An Executive Order further requires the use of the metadata content standard to document digital spatial data sets. Collection and reporting of spatial metadata for field investigations performed for the federal government is an anticipated requirement. This paper provides an overview of the draft spatial metadata content standard and a description of how the standard could be applied to investigations collecting spatially-referenced field data.

CO2 Measurements from Space: Lessons Learned from the Collaboration between the ACOS/OCO-2 and GOSAT Teams

Science.gov (United States)

Crisp, D.; Eldering, A.; Gunson, M. R.

2012-12-01

The NASA Orbiting Carbon Observatory (OCO) and the Japanese Greenhouse gases Observing SATellite (GOSAT) were the first two missions designed to collect space-based observations of the column-averaged CO2 dry air mole fraction, XCO2, with the sensitivity, coverage, and resolution needed to quantify CO2 fluxes on regional scales over the globe. The OCO and GOSAT teams formed a close collaboration during the development phases of these missions. After the loss of OCO, the GOSAT project team invited the OCO team to contribute to the analysis of measurements collected by the GOSAT Thermal And Near infrared Sensor for carbon Observations-Fourier Transform Spectrometer (TANSO-FTS). NASA responded by reformulating the OCO science team under the Atmospheric CO2 Observations from Space (ACOS) task to exploit this opportunity. This collaboration is providing an independent GOSAT XCO2 product, and valuable insights into the retrieval algorithms, calibration methods, and validation techniques that are being developed to analyze data anticipated the NASA Orbiting Carbon Observatory-2 (OCO-2). The ACOS/OCO-2 and GOSAT teams have conducted four, joint, vicarious calibration campaigns at Railroad Valley, Nevada to track the long-term radiometric performance of the TANSO-FTS instrument. The methods used in these campaigns evolved from those used to characterize the radiometric performance of high spatial resolution, imaging spectroradiometers. For TANSO-FTS, the conventional, surface based radiometric measurements have been augmented with surface and aircraft measurements of atmospheric temperature and trace gas profiles, as well as surface observations from MODIS and ASTER to characterize spatial variations of the surface reflectance within the (relatively large) sounding footprints. Similar methods will be needed for OCO-2. The ACOS/OCO-2 retrieval algorithm and associated data screening methods have been modified to estimate XCO2 from TANSO-FTS observations. Comparisons of TANSO

Development of ASTM Standard for SiC-SiC Joint Testing Final Scientific/Technical Report

Energy Technology Data Exchange (ETDEWEB)

Jacobsen, George [General Atomics, San Diego, CA (United States); Back, Christina [General Atomics, San Diego, CA (United States)

2015-10-30

As the nuclear industry moves to advanced ceramic based materials for cladding and core structural materials for a variety of advanced reactors, new standards and test methods are required for material development and licensing purposes. For example, General Atomics (GA) is actively developing silicon carbide (SiC) based composite cladding (SiC-SiC) for its Energy Multiplier Module (EM2), a high efficiency gas cooled fast reactor. Through DOE funding via the advanced reactor concept program, GA developed a new test method for the nominal joint strength of an endplug sealed to advanced ceramic tubes, Fig. 1-1, at ambient and elevated temperatures called the endplug pushout (EPPO) test. This test utilizes widely available universal mechanical testers coupled with clam shell heaters, and specimen size is relatively small, making it a viable post irradiation test method. The culmination of this effort was a draft of an ASTM test standard that will be submitted for approval to the ASTM C28 ceramic committee. Once the standard has been vetted by the ceramics test community, an industry wide standard methodology to test joined tubular ceramic components will be available for the entire nuclear materials community.

Interface bonding of SA508-3 steel under deformation and high temperature diffusion

Science.gov (United States)

Xu, Bin; Shao, Chunjuan; Sun, Mingyue

2018-05-01

There are mainly two parameters affecting high temperature interface bonding: deformation and diffusion. To study these two parameters, interface bonding of SA508-3 bainitic steel at 1100°C are simulated by gleeble3500 thermal simulator. The results show that interface of SA508-3 steel can be bonded under deformation and high temperature. For a specimen pressed at 1100°C without further high temperature diffusion, a reduction ratio of 30% can make the interface begun to bond, but the interface is still part of the grain boundary and small grains exist near the interface. When reduction ratio reaches 50%, the interface can be completely bonded and the microstructure near the interface is the same as that of the base material. When deformation is small, long time diffusion can also help the interface bonding. The results show that when the diffusion time is long enough, the interface under small deformation can also be bonded. For a specimen holding for 24h at 1100°C, only 13% reduction ratio is enough for interface bonding.

Validation of the concept Risk for Decreased Cardiac Output Validación del concepto riesgo de débito cardiaco disminuido Validação do conceito risco de débito cardíaco diminuído

Directory of Open Access Journals (Sweden)

Eduarda Ribeiro dos Santos

2013-02-01

Full Text Available OBJECTIVES: to validate the concept "risk for decreased cardiac output". METHOD: Six of the eight steps suggested in the technique developed by Walker & Avant were adopted to analyze the concept of the phenomenon under study and the proposal made by Hoskins was used for content validation, taking into account agreement achieved among five experts. RESULTS: the concept "decreased cardiac output" was found in the nursing and medical fields and refers to the heart's pumping capacity while the concept "risk" is found in a large number of disciplines. In regard to the defining attributes, "impaired pumping capacity" was the main attribute of decreased cardiac output and "probability" was the main attribute of risk. The uses and defining attributes of the concepts "decreased cardiac output" and "risk" were analyzed as well as their antecedent and consequent events in order to establish the definition of "risk for decreased cardiac output", which was validated by 100% of the experts. CONCLUSION: The obtained data indicate that the risk for decreased cardiac output phenomenon can be a nursing diagnosis and refining it can contribute to the advancement of nursing classifications in this context.OBJETIVO: Validar el concepto riesgo del débito cardíaco disminuido. MÉTODO: Fue adoptada la técnica de Walker & Avant para analizar la definición del fenómeno enfocado, utilizando seis de las ocho etapas sugeridas y la propuesta de Hoskins para validar el contenido, considerándose la conformidad entre cinco expertos. RESULTADOS: el concepto de debito cardíaco disminuido se encuentra en las áreas enfermería y médica y su atención se centra en la capacidad de bombeo del corazón. Sin embargo, el concepto de riesgo es presente en un gran número de áreas. Las características definitorias de la disminución del gasto cardíaco mostraron como principal atributo deficiencia de la bomba cardiaca y, para el riesgo, el atributo de probabilidad. Analizados

Manejo de las dislipidemias en pacientes cardíacos trasplantados. Hallazgos sobre nuevos factores de riesgo

OpenAIRE

Walter Masson; Norberto Vulcano; Sandra Fernández; Alberto Domenech; Ricardo Marenchino; Daniel Bracco; César Belziti

2008-01-01

En pacientes cardíacos trasplantados, el desarrollo de enfermedad vascular coronaria es una complicación frecuente y la dislipidemia es uno de los predictores más importantes. Los inmunosupresores predisponen a las dislipidemias y dificultan la utilización de hipolipemiantes. En este grupo particular de pacientes se recomienda alcanzar las metas terapéuticas de prevención secundaria. Las estatinas son los hipolipemiantes de elección. No existen recomendaciones claras sobre nuevos factores de ...

Manejo de las dislipidemias en pacientes cardíacos trasplantados: Hallazgos sobre nuevos factores de riesgo

OpenAIRE

Masson, Walter; Vulcano, Norberto; Fernández, Sandra; Domenech, Alberto; Marenchino, Ricardo; Braccomtsac, Daniel; Belziti, César

2008-01-01

En pacientes cardíacos trasplantados, el desarrollo de enfermedad vascular coronaria es una complicación frecuente y la dislipidemia es uno de los predictores más importantes. Los inmunosupresores predisponen a las dislipidemias y dificultan la utilización de hipolipemiantes. En este grupo particular de pacientes se recomienda alcanzar las metas terapéuticas de prevención secundaria. Las estatinas son los hipolipemiantes de elección. No existen recomendaciones claras sobre nuevos factores de ...

Characterization of ASTM A335 P92 steel in continuous cooling cycles

International Nuclear Information System (INIS)

Xaubet, M. N.; Danón, C. A.; Ramos, C. P.

2013-01-01

The operating conditions demanded by Generation IV reactors include high temperatures, higher radiation doses and highly corrosive environments. Among the structural materials proposed both for in-core and out-of-core applications, elevated-temperature P91/P92 ferritic/martensitic steels have been considered. This work studies the transformation behavior and microstructural evolution of ASTM A335 P92 steel in continuous cooling cycles (CCT). The material was austenized at 1050 ºC and afterwards cooled down at controlled rates (300, 50 and 15 ºC/h). The determination and characterization of the phases present in the samples was performed by optical microscopy, field emission scanning electron microscopy, Mössbauer spectroscopy and X-ray diffraction. Samples whose cooling rates were on the limits of the studied range (300 and 15 ºC/h) presented completely martensitic and completely ferritic structures, respectively. The sample cooled down at intermediate rate exhibited, though, a mixed structure of martensite and ferrite. Second-phase precipitation has also been observed in all the samples. (author)

Spontaneous ignition in afterburner segment tests at an inlet temperature of 1240 K and a pressure of 1 atmosphere with ASTM jet-A fuel

Science.gov (United States)

Schultz, D. F.; Branstetter, J. R.

1973-01-01

A brief testing program was undertaken to determine if spontaneous ignition and stable combustion could be obtained in a jet engine afterburning operating with an inlet temperature of 1240 K and a pressure of 1 atmosphere with ASTM Jet-A fuel. Spontaneous ignition with 100-percent combustion efficiency and stable burning was obtained using water-cooled fuel spraybars as flameholders.

Impact of the [delta]F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure

Energy Technology Data Exchange (ETDEWEB)

Lewis, Hal A.; Zhao, Xun; Wang, Chi; Sauder, J. Michael; Rooney, Isabelle; Noland, Brian W.; Lorimer, Don; Kearins, Margaret C.; Conners, Kris; Condon, Brad; Maloney, Peter C.; Guggino, William B.; Hunt, John F.; Emtage, Spencer (SG); (Columbia); (JHU)

2010-07-19

Cystic fibrosis is caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR), commonly the deletion of residue Phe-508 (DeltaF508) in the first nucleotide-binding domain (NBD1), which results in a severe reduction in the population of functional channels at the epithelial cell surface. Previous studies employing incomplete NBD1 domains have attributed this to aberrant folding of DeltaF508 NBD1. We report structural and biophysical studies on complete human NBD1 domains, which fail to demonstrate significant changes of in vitro stability or folding kinetics in the presence or absence of the DeltaF508 mutation. Crystal structures show minimal changes in protein conformation but substantial changes in local surface topography at the site of the mutation, which is located in the region of NBD1 believed to interact with the first membrane spanning domain of CFTR. These results raise the possibility that the primary effect of DeltaF508 is a disruption of proper interdomain interactions at this site in CFTR rather than interference with the folding of NBD1. Interestingly, increases in the stability of NBD1 constructs are observed upon introduction of second-site mutations that suppress the trafficking defect caused by the DeltaF508 mutation, suggesting that these suppressors might function indirectly by improving the folding efficiency of NBD1 in the context of the full-length protein. The human NBD1 structures also solidify the understanding of CFTR regulation by showing that its two protein segments that can be phosphorylated both adopt multiple conformations that modulate access to the ATPase active site and functional interdomain interfaces.

The Ricor K508 cryocooler operational experience on Mars

Energy Technology Data Exchange (ETDEWEB)

Johnson, Dean L.; Lysek, Mark J.; Morookian, John Michael [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States)

2014-01-29

The Mars Science Laboratory (Curiosity) landed successfully on Mars on August 5, 2012, eight months after launch. The chosen landing site of Gale Crater, located at 4.5 degrees south latitude, 137.4 degrees east longitude, has provided a much more benign environment than was originally planned for during the critical design and integration phases of the MSL Project when all possible landing sites were still being considered. The expected near-surface atmospheric temperatures at the Gale Crater landing site during Curiosity's primary mission (1 Martian year or 687 Earth days) are from −90°C to 0°C. However, enclosed within Curiosity's thermal control fluid loops the Chemistry and Mineralogy (CheMin) instrument is maintained at approximately +20°C. The CheMin instrument uses X-ray diffraction spectroscopy to make precise measurements of mineral constituents of Mars rocks and soil. The instrument incorporated the commercially available Ricor K508 Stirling cycle cryocooler to cool the CCD detector. After several months of brushing itself off, stretching and testing out its subsystems, Curiosity began the exploration of the Mars surface in October 2012. The CheMin instrument on the Mars Science Laboratory (MSL) received its first soil sample from Curiosity on October 24, and successfully analyzed its first soil sample. After a brief review of the rigorous Ricor K508 cooler qualification tests and life tests based on the original MSL environmental requirements this paper presents final pre-launch instrument integration and testing results, and details the operational data of the CheMin cryocooler, providing a snapshot of the resulting CheMin instrument analytical data.

The Ricor K508 cryocooler operational experience on Mars

International Nuclear Information System (INIS)

Johnson, Dean L.; Lysek, Mark J.; Morookian, John Michael

2014-01-01

The Mars Science Laboratory (Curiosity) landed successfully on Mars on August 5, 2012, eight months after launch. The chosen landing site of Gale Crater, located at 4.5 degrees south latitude, 137.4 degrees east longitude, has provided a much more benign environment than was originally planned for during the critical design and integration phases of the MSL Project when all possible landing sites were still being considered. The expected near-surface atmospheric temperatures at the Gale Crater landing site during Curiosity's primary mission (1 Martian year or 687 Earth days) are from −90°C to 0°C. However, enclosed within Curiosity's thermal control fluid loops the Chemistry and Mineralogy (CheMin) instrument is maintained at approximately +20°C. The CheMin instrument uses X-ray diffraction spectroscopy to make precise measurements of mineral constituents of Mars rocks and soil. The instrument incorporated the commercially available Ricor K508 Stirling cycle cryocooler to cool the CCD detector. After several months of brushing itself off, stretching and testing out its subsystems, Curiosity began the exploration of the Mars surface in October 2012. The CheMin instrument on the Mars Science Laboratory (MSL) received its first soil sample from Curiosity on October 24, and successfully analyzed its first soil sample. After a brief review of the rigorous Ricor K508 cooler qualification tests and life tests based on the original MSL environmental requirements this paper presents final pre-launch instrument integration and testing results, and details the operational data of the CheMin cryocooler, providing a snapshot of the resulting CheMin instrument analytical data

Non typical results of the first and second irradiation set of the surveillance programme of a boiling water reactor in Switzerland

Energy Technology Data Exchange (ETDEWEB)

Ullrich, G; Krompholz, K [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

1994-12-31

In the surveillance programme for the pressure vessel of the Muhleberg NPP in Switzerland, tensile and impact tests on the base material (ASTM A 508 Cl 2) and two weldments (main and automatic) as well as the heat affected zone, were performed with two sets of irradiation (neutron fluence of 5.5.10{sup 17} and 1.1.10{sup 18}) leading to different shifts of the transition temperature (except for the automatic welded joints which keep the same large shift). Results and causes of the discrepancy are discussed. (authors). 6 figs., 2 tabs.

Avaliação do sopro cardíaco na infância Assessment of heart murmurs in childhood

Directory of Open Access Journals (Sweden)

Maria Elisabeth B.A. Kobinger

2003-06-01

Full Text Available OBJETIVO: discutir a avaliação clínica e laboratorial do sopro cardíaco, considerando sua alta freqüência no atendimento ambulatorial do pediatra geral. FONTE DE DADOS: revisão baseada na análise crítica da literatura atual e consulta a compêndios de cardiologia pediátrica e pediatria contendo informações básicas sobre o tema. SÍNTESE DOS DADOS: os principais destaques do artigo referem-se à importância da anamnese e exame físico do sistema cardiovascular, essenciais para o pediatra geral diagnosticar o sopro cardíaco inocente, e identificar situações que indiquem a ocorrência de cardiopatias congênitas, ou adquiridas, e a necessidade de encaminhamento ao especialista. CONCLUSÕES: o pediatra geral é geralmente o primeiro médico a detectar um sopro cardíaco e deve estar apto a reconhecer o sopro inocente, assim como a suspeitar precocemente de doenças cardiovasculares.OBJECTIVE: to discuss clinical and laboratorial evaluation of heart murmurs in children, an important problem faced by pediatricians in their practice. SOURCES OF DATA: this review was based on a critical analysis of the current literature, as well as pediatrics and pediatric cardiology textbooks, which were found to be an important source of information on the subject. SUMMARY OS THE FINDINGS: it is important for pediatricians to know how to obtain precise information regarding the patient's medical history and to perform extensive physical examination of a child with heart murmur. The diagnosis of innocent heart murmur is essentially clinical and it can help the pediatrician to identify situations which are associated with cardiovascular diseases. CONCLUSIONS: in our series, short-term video-EEG monitoring established a reliable diagnosis in most patients due to correlation between clinical and EEG data. This procedure was well tolerated by children, including infants and those with psychiatric disorders.

The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif.

Science.gov (United States)

Ross, Peter; Nemec, Paige S; Kapatos, Alexander; Miller, Keith R; Holmes, Jennifer C; Suter, Steven E; Buntzman, Adam S; Soderblom, Erik J; Collins, Edward J; Hess, Paul R

2018-03-01

Ideally, CD8+ T-cell responses against virally infected or malignant cells are defined at the level of the specific peptide and restricting MHC class I element, a determination not yet made in the dog. To advance the discovery of canine CTL epitopes, we sought to determine whether a putative classical MHC class Ia gene, Dog Leukocyte Antigen (DLA)-88, presents peptides from a viral pathogen, canine distemper virus (CDV). To investigate this possibility, DLA-88*508:01, an allele prevalent in Golden Retrievers, was expressed as a FLAG-tagged construct in canine histiocytic cells to allow affinity purification of peptide-DLA-88 complexes and subsequent elution of bound peptides. Pattern analysis of self peptide sequences, which were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS), permitted binding preferences to be inferred. DLA-88*508:01 binds peptides that are 9-to-12 amino acids in length, with a modest preference for 9- and 11-mers. Hydrophobic residues are favored at positions 2 and 3, as are K, R or F residues at the C-terminus. Testing motif-matched and -unmatched synthetic peptides via peptide-MHC surface stabilization assay using a DLA-88*508:01-transfected, TAP-deficient RMA-S line supported these conclusions. With CDV infection, 22 viral peptides ranging from 9-to-12 residues in length were identified in DLA-88*508:01 eluates by LC-MS/MS. Combined motif analysis and surface stabilization assay data suggested that 11 of these 22 peptides, derived from CDV hemagglutinin, large polymerase, matrix, nucleocapsid, and V proteins, were processed and presented, and thus, potential targets of anti-viral CTL in DLA-88*508:01-bearing dogs. The presentation of diverse self and viral peptides indicates that DLA-88 is a classical MHC class Ia gene. Copyright © 2018 Elsevier B.V. All rights reserved.

Impact of ASTM Standard E722 update on radiation damage metrics

Energy Technology Data Exchange (ETDEWEB)

DePriest, Kendall Russell [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2014-06-01

The impact of recent changes to the ASTM Standard E722 is investigated. The methodological changes in the production of the displacement kerma factors for silicon has significant impact for some energy regions of the 1-MeV(Si) equivalent fluence response function. When evaluating the integral over all neutrons energies in various spectra important to the SNL electronics testing community, the change in the response results in an increase in the total 1-MeV(Si) equivalent fluence of 2 7%. Response functions have been produced and are available for users of both the NuGET and MCNP codes.

Improved ASTM G72 Test Method for Ensuring Adequate Fuel-to-Oxidizer Ratios

Science.gov (United States)

Juarez, Alfredo; Harper, Susana Tapia

2016-01-01

The ASTM G72/G72M-15 Standard Test Method for Autogenous Ignition Temperature of Liquids and Solids in a High-Pressure Oxygen-Enriched Environment is currently used to evaluate materials for the ignition susceptibility driven by exposure to external heat in an enriched oxygen environment. Testing performed on highly volatile liquids such as cleaning solvents has proven problematic due to inconsistent test results (non-ignitions). Non-ignition results can be misinterpreted as favorable oxygen compatibility, although they are more likely associated with inadequate fuel-to-oxidizer ratios. Forced evaporation during purging and inadequate sample size were identified as two potential causes for inadequate available sample material during testing. In an effort to maintain adequate fuel-to-oxidizer ratios within the reaction vessel during test, several parameters were considered, including sample size, pretest sample chilling, pretest purging, and test pressure. Tests on a variety of solvents exhibiting a range of volatilities are presented in this paper. A proposed improvement to the standard test protocol as a result of this evaluation is also presented. Execution of the final proposed improved test protocol outlines an incremental step method of determining optimal conditions using increased sample sizes while considering test system safety limits. The proposed improved test method increases confidence in results obtained by utilizing the ASTM G72 autogenous ignition temperature test method and can aid in the oxygen compatibility assessment of highly volatile liquids and other conditions that may lead to false non-ignition results.

Tekken tests in a steel 'ASTM A 514 GR B' to determine the preheating temperature

International Nuclear Information System (INIS)

Quesada, Hector Juan; Zalazar, Monica; Asta, Eduardo Pablo

2004-01-01

Cold fissure tests are used to determine the proper preheating temperature in order to prevent fissures during the steel welding process. Tekken tests were carried out on a quenched and tempered high resistance 25.4 mm thick steel (ASTM A514 Gr.B) used in structural applications. The welding was carried out using a FCAW semiautomatic process with gas protection and low hydrogen tubular electrode E110T5-K4. Similar parameters and splicing design were later applied in production. The microstructures of the base material and the welding were determined by optic and electron microscopy. The thermal cycles of the welding were recorded in order to relate the preheating temperature with the cooling time from 800 o C - 500 o C (t 8/5 ) and from 800 o C - 100 o C (tg/1) and the presence or not of fissures. Preheating at 150 o C and t 8/5 greater than 17 s was found to guarantee fissure free welding (CW)

Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway.

Science.gov (United States)

Suriyo, Tawit; Tachachartvanich, Phum; Visitnonthachai, Daranee; Watcharasit, Piyajit; Satayavivad, Jutamaad

2015-12-02

Aside from the effects on neuronal cholinergic system, epidemiological studies suggest an association between chlorpyrifos (CPF) exposure and cancer risk. This in vitro study examined the effects of CPF and its toxic metabolite, chlorpyrifos oxon (CPF-O), on the growth of human colorectal adenocarcinoma H508, colorectal adenocarcinoma HT-29, normal colon epithelial CCD841, liver hepatocellular carcinoma HepG2, and normal liver hepatocyte THLE-3 cells. The results showed that CPF (5-100 μM) concentration-dependently increased viability of H508 and CCD841 cells in serum-free conditions. This increasing trend was not found in HT-29, HepG2 and THLE-3 cells. In contrast, CPF-O (50-100 μM) reduced the viability of all cell lines. Cell cycle analysis showed the induction of cells in the S phase, and EdU incorporation assay revealed the induction of DNA synthesis in CPF-treated H508 cells indicating that CPF promotes cell cycle progression. Despite the observation of acetylcholinesterase activity inhibition and reactive oxygen species (ROS) generation, atropine (a non-selective muscarinic acetylcholine receptor antagonist) and N-acetylcysteine (a potent antioxidant) failed to inhibit the growth-promoting effect of CPF. CPF increased the phosphorylation of epidermal growth factor receptor (EGFR) and its downstream effector, extracellular signal regulated kinase (ERK1/2), in H508 cells. AG-1478 (a specific EGFR tyrosine kinase inhibitor) and U0126 (a specific MEK inhibitor) completely mitigated the growth promoting effect of CPF. Altogether, these results suggest that EGFR/ERK1/2 signaling pathway but not cholinergic pathway involves in CPF-induced colorectal adenocarcinoma H508 cell growth. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Characterization of microstructure of A508III/309L/308L weld and oxide films formed in deaerated high-temperature water

Science.gov (United States)

Xiong, Qi; Li, Hongjuan; Lu, Zhanpeng; Chen, Junjie; Xiao, Qian; Ma, Jiarong; Ru, Xiangkun

2018-01-01

The microstructure of A508III/309L/308L weld clad and the properties of the oxide films formed in simulated pressurized water reactor primary water at 290 °C were characterized. The A508III heat-affected zone (HAZ) consisted primarily of a decarburization zone with ferrite near the fusion line and a following pearlite structure with fine grains. A high hardness region in the HAZ could be the result of C-enrichment. M23C6 and M7C3 precipitates were observed in element transition zone. 308L stainless steel (SS) containing ∼ 12% ferrites exhibited both ferritic-austenitic solidification mode (FA mode, δ→γ) and austenitic-ferritic solidification mode (AF mode, γ→δ), whereas 309L SS containing ∼ 9% ferrites exhibited only FA mode. The A508III surface oxide film was mainly Fe3O4 in deaerated high-temperature water. The coarse grain zone covered with few oxide particles was different from other types of film on the other region of HAZ and the bulk zone. More pitting appears on 309L SS after immersion in deaerated high-temperature water due to the dissolution of inclusions. SS surface oxide films consisted primarily of spinels. The oxide film on SS was divided into two layers. Ni was concentrated mainly at the oxide/substrate interface. The oxide film formed on 309L was thicker than that on the 308L. The ferrite in the stainless steel could improve the oxidation resistance.

Use of Bayesian Methods to Analyze and Visualize Content Uniformity Capability Versus United States Pharmacopeia and ASTM Standards.

Science.gov (United States)

Hofer, Jeffrey D; Rauk, Adam P

2017-02-01

The purpose of this work was to develop a straightforward and robust approach to analyze and summarize the ability of content uniformity data to meet different criteria. A robust Bayesian statistical analysis methodology is presented which provides a concise and easily interpretable visual summary of the content uniformity analysis results. The visualization displays individual batch analysis results and shows whether there is high confidence that different content uniformity criteria could be met a high percentage of the time in the future. The 3 tests assessed are as follows: (a) United States Pharmacopeia Uniformity of Dosage Units , (b) a specific ASTM E2810 Sampling Plan 1 criterion to potentially be used for routine release testing, and (c) another specific ASTM E2810 Sampling Plan 2 criterion to potentially be used for process validation. The approach shown here could readily be used to create similar result summaries for other potential criteria. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Quantifying Spatiotemporal Dynamics of Solar Radiation over the Northeast China Based on ACO-BPNN Model and Intensity Analysis

Directory of Open Access Journals (Sweden)

Xiangqian Li

2017-01-01

Full Text Available Reliable information on the spatiotemporal dynamics of solar radiation plays a crucial role in studies relating to global climate change. In this study, a new backpropagation neural network (BPNN model optimized with an Ant Colony Optimization (ACO algorithm was developed to generate the ACO-BPNN model, which had demonstrated superior performance for simulating solar radiation compared to traditional BPNN modelling, for Northeast China. On this basis, we applied an intensity analysis to investigate the spatiotemporal variation of solar radiation from 1982 to 2010 over the study region at three levels: interval, category, and conversion. Research findings revealed that (1 the solar radiation resource in the study region increased from the 1980s to the 2000s and the average annual rate of variation from the 1980s to the 1990s was lower than that from the 1990s to the 2000s and (2 the gains and losses of solar radiation at each level were in different conditions. The poor, normal, and comparatively abundant levels were transferred to higher levels, whereas the abundant level was transferred to lower levels. We believe our findings contribute to implementing ad hoc energy management strategies to optimize the use of solar radiation resources and provide scientific suggestions for policy planning.

Status on the selection and development of an embrittlement trend curve to use in ASTM standard guide E900

International Nuclear Information System (INIS)

Kirk, M.; Brian Hall, J.; Server, W.; Lucon, E.; Erickson, M.; Stoller, R.

2015-01-01

ASTM E900-07, Standard Guide for Predicting Radiation-Induced Transition Temperature Shift in Reactor Vessel Materials, includes an embrittlement trend curve. The trend curve can be used to predict the effect of neutron irradiation on the embrittlement of ferritic pressure vessel steels, as quantified by the shift in the Charpy V-Notch transition curve at 41 Joules of absorbed energy (ΔT 41J ). The current E900 trend curve was first adopted in the 2002 revision. In 2011 ASTM Subcommittee E10.02 undertook an extensive effort to evaluate the adequacy of the E900 trend curve for continued use. This paper summarizes the current status of this effort, which has produced a trend curve calibrated using a database of over 1800 ΔT 41J values from the light water reactor surveillance programs in thirteen countries. (authors)

Modeling flow stress constitutive behavior of SA508-3 steel for nuclear reactor pressure vessels

Energy Technology Data Exchange (ETDEWEB)

Sun Mingyue, E-mail: mysun@imr.ac.cn [Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016 (China); Luhan, Hao; Shijian, Li; Dianzhong, Li; Yiyi, Li [Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016 (China)

2011-11-15

Highlights: > A series of flow stress constitutive equations for SA508-3 steel were successfully established. > The experimental results under different conditions have validated the constitutive equations. > An industrial application of the model was present to simulate a large conical shell forging process. - Abstract: Based on the measured stress-strain curves under different temperatures and strain rates, a series of flow stress constitutive equations for SA508-3 steel were firstly established through the classical theories on work hardening and softening. The comparison between the experimental and modeling results has confirmed that the established constitutive equations can correctly describe the mechanical responses and microstructural evolutions of the steel under various hot deformation conditions. We further represented a successful industrial application of this model to simulate a forging process for a large conical shell used in a nuclear steam generator, which evidences its practical and promising perspective of our model with an aim of widely promoting the hot plasticity processing for heavy nuclear components of fission reactors.

31 CFR 586.508 - Entries in certain accounts for normal service charges authorized.

Science.gov (United States)

2010-07-01

... institution by the owner of such blocked account. (b) As used in this section, the term normal service charge..., and Statements of Licensing Policy § 586.508 Entries in certain accounts for normal service charges... by way of limitation, minimum balance charges, notary and protest fees, and charges for reference...

Fitting psychometric functions using a fixed-slope parameter: an advanced alternative for estimating odor thresholds with data generated by ASTM E679.

Science.gov (United States)

Peng, Mei; Jaeger, Sara R; Hautus, Michael J

2014-03-01

Psychometric functions are predominately used for estimating detection thresholds in vision and audition. However, the requirement of large data quantities for fitting psychometric functions (>30 replications) reduces their suitability in olfactory studies because olfactory response data are often limited (ASTM) E679. The slope parameter of the individual-judge psychometric function is fixed to be the same as that of the group function; the same-shaped symmetrical sigmoid function is fitted only using the intercept. This study evaluated the proposed method by comparing it with 2 available methods. Comparison to conventional psychometric functions (fitted slope and intercept) indicated that the assumption of a fixed slope did not compromise precision of the threshold estimates. No systematic difference was obtained between the proposed method and the ASTM method in terms of group threshold estimates or threshold distributions, but there were changes in the rank, by threshold, of judges in the group. Overall, the fixed-slope psychometric function is recommended for obtaining relatively reliable individual threshold estimates when the quantity of data is limited.

Trasplante cardíaco en pacientes con enfermedad de Chagas. Experiencia de un único centro

Directory of Open Access Journals (Sweden)

Alfredo Inácio Fiorelli

2011-07-01

Conclusiones: El trasplante cardíaco es el único tratamiento actual eficaz de tratamiento de la enfermedad de Chagas en fase terminal. La reactivación de la enfermedad es un problema real que es fácilmente revertido con la introducción de la terapéutica farmacológica específica, restaurando los padrones histológicos del miocardio sin dejar secuelas. La inmunosupresión, en especial los corticoides, predisponen al desarrollo de neoplasias y a la reactivación de la enfermedad, exigiendo una atención especial su interrupción o reducción precoz.

Application of Response Surface Methodology for Modeling of Postweld Heat Treatment Process in a Pressure Vessel Steel ASTM A516 Grade 70.

Science.gov (United States)

Peasura, Prachya

2015-01-01

This research studied the application of the response surface methodology (RSM) and central composite design (CCD) experiment in mathematical model and optimizes postweld heat treatment (PWHT). The material of study is a pressure vessel steel ASTM A516 grade 70 that is used for gas metal arc welding. PWHT parameters examined in this study included PWHT temperatures and time. The resulting materials were examined using CCD experiment and the RSM to determine the resulting material tensile strength test, observed with optical microscopy and scanning electron microscopy. The experimental results show that using a full quadratic model with the proposed mathematical model is YTS = -285.521 + 15.706X1 + 2.514X2 - 0.004X1(2) - 0.001X2(2) - 0.029X1X2. Tensile strength parameters of PWHT were optimized PWHT time of 5.00 hr and PWHT temperature of 645.75°C. The results show that the PWHT time is the dominant mechanism used to modify the tensile strength compared to the PWHT temperatures. This phenomenon could be explained by the fact that pearlite can contribute to higher tensile strength. Pearlite has an intensity, which results in increased material tensile strength. The research described here can be used as material data on PWHT parameters for an ASTM A516 grade 70 weld.

Effect of C content on the mechanical properties of solution treated as-cast ASTM F-75 alloys.

Science.gov (United States)

Herrera, M; Espinoza, A; Méndez, J; Castro, M; López, J; Rendón, J

2005-07-01

The mechanical properties of solution treated ASTM F-75 alloys with various carbon contents have been studied. Alloys cast under the same conditions were subjected to solution treatment for several periods and then their tensile properties were evaluated. In the as-cast conditions, the alloys exhibited higher strength values with increasing carbon content whereas their ductility was not significantly affected. For the solution treated alloys, the variation of the strength was characterized by a progressive increase for short treatment times until a maximum value was achieved, which was followed by a diminution in this property for longer treatment times. This behavior was more accentuated for the case of the alloys with medium carbon contents, which also exhibited the highest values of strength. Furthermore, the alloy's ductility was enhanced progressively with increasing solution treatment time. This improvement in ductility was significantly higher for the medium carbon alloys compared with the rest of the studied alloys. Thus, high and low carbon contents in solution treated ASTM F-75 alloys did not produced sufficiently high tensile properties.

30 CFR 77.508 - Lightning arresters, ungrounded and exposed power conductors and telephone wires.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Lightning arresters, ungrounded and exposed... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Electrical Equipment-General § 77.508 Lightning... conductors and telephone wires shall be equipped with suitable lightning arresters which are adequately...

Structural effects of hydrogen action in the low alloy Mn-Ni-Mo (A508.3) steel

International Nuclear Information System (INIS)

Sozanska, M.; Maciejny, A.; Sojka, J.; Hyspecka, L.; Galland, J.

1999-01-01

The presented paper deals with the study of hydrogen embrittlement of A508.3 steel used in nuclear industry. The effects in hydrogen are investigated by means of tensile testes on hydrogen charged specimens. The degree of degradation of mechanical properties is the first and the most important criterion of susceptibility to hydrogen embrittlement. The second criterion represents changes in failure micro mechanisms provoked by presence of hydrogen in microstructure or in the surface fracture. For this steel, hydrogen provoked special defects called 'fish eyes' on surface fractures after tensile tests. 'Fish eyes' nucleated on course spherical non-metallic inclusions. Inclusions were identified in most cases as a complex oxides containing variable quantities namely Al, Mg, Si, and Ca, the outer shell being formed by (Ca, Mn)S. Special attention was given to the detailed metallographic analysis by means of light and scanning electron microscopy, including the methods of image analysis, local chemical analysis, quantitative metallography quantitative fractography. Metallographic methods are explained by nonmetallic inclusion morphology. Inclusions were evaluated by means of image analysis and the results obtained have shown inclusion content and their geometric characteristics. Fractographic methods are used in quantitative characteristic of different types of fracture surfaces (ductile, quasicleavage and 'fish eyes') and parameters of 'fish eyes' (their number per unit of fracture area, diameter, surface, shape). All results obtained in this way can be used to describe more precisely the specific mechanism of hydrogen embrittlement in A508.3 steel. (author)

Microstructure and mechanical property change of dissimilar metal welds Alloy 600 - Alloy 182 - A508 Gr. 3 according to thermal aging effect at 400 .deg. C

Energy Technology Data Exchange (ETDEWEB)

Ham, Jun Hyuk; Choi, Kyoung Joon; Kim, Ji Hyun [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)

2015-10-15

To prevent such critical matters above mentioned, investigation about degradation mechanism of materials by thermal aging should be conducted. However, there are no sufficient studies on this field. Therefore, the final goal of this study is to investigate microstructure along the DMW undergone thermal aging process. Firstly, in order to get a reference data for further comparison analysis which is expected to show degradation mechanism of the weld joint, un-heated weld joint was investigated with several instruments, Vickers hardness tester, scanning electron microscope (SEM), and an energy-dispersive X-ray spectrometer (EDS). Detail instrumental analysis in Alloy 600 - Alloy 182 - A508 Gr. 3 DMW joint were performed in order to investigate microstructure and mechanical properties of material. Following conclusions can be drawn from this study. Alloy 182 has austenitic dendrite structure which is formed by heat flow during welding process. Type-II boundaries were observed at the interface between Alloy 182 and A508 Gr. 3. Chemical composition shows rapid transition at the interface which makes 3000 µm of chromium dilution zone. Microstructure of A508 Gr. 3 was investigated from the interface between Alloy 182 to base metal.

Glove powder's carrying capacity for latex protein: analysis using the ASTM ELISA test.

Science.gov (United States)

Beezhold, D; Horton, K; Hickey, V; Daddona, J; Kostyal, D

2003-01-01

Glove donning powders carry latex proteins and disperse them into the workplace environment. We have used the ASTM D6499 ELISA to quantify the amount of latex antigen bound to and carried by glove powders. We could differentiate between a small amount of protein actually bound to the powders and a larger amount carried by the powder. Enhanced binding of a major allergen, Hev b 5, to the starch powders was demonstrated by Western blot. The D6499 ELISA is able to measure total latex antigen, soluble and powder bound, simultaneously without the need to centrifuge the samples.

The new ASTM Manual for scrubber linings the evolution of a consensus guide

International Nuclear Information System (INIS)

Spires, G.V.; Cavallo, J.R.

1984-01-01

Faced with spiraling fuel oil costs, power utilities turned to abundant and inexpensive domestic coal and lignite. Conversions and new units designed to burn solid fossil fuels were pursued at a near crisis pace to get out from under the economic penalties associated with the continued use of oil. Coal contains much more sulfur than oil; EPA limitations on SO 2 necessitated costly flue gas desulfurization (FGD) systems when burning coal. Scrubbed gas presented a particularly corrosive environment in and downstream from the FGD system. Problems which often accompany a new technology were soon evident. Materials and linings initially selected were often seen to be inadequate. Severe and rapid degradation was commonplace. This paper traces the development of the recently published ASTM Manual of Protective Linings From Flue Gas Desulfurization System. The scope of the Manual is outlined and some of the more commonly used FGD lining systems are reviewed. Finally some views on the impact of foreseeable changes in regulations and FGD technology on the use and maintenance of FGD system linings are discussed

Data development for ASTM E24.06.02 round robin program on instability prediction

Science.gov (United States)

Mccabe, D. E.

1979-01-01

Basis data for use in an ASTM E24.06.02 task group round robin activity was developed. Compact specimens were made of 2024-T351, 7075-T651 aluminum alloys, and 304 stainless steel. All were 12.7 mm thick and planar dimension variables incorporated were for 1T, 2T and 4T sizes. Representative raw data for each material and specimen size are contained herein. R-curves plotted in terms of delta a physical and delta a effective are plotted for each material.

MULTICOMPONENT AND REGIOSELECTIVE SYNTHESIS OF DIHYDROPYRAZOLO[1,5-a]PYRIMIDINES FROM AROMATIC ALDEHYDES, MELDRUM'S ACID AND AMINOPYRAZOLE CAN508

OpenAIRE

Jedinák, L.; Kryštof, V. (Vladimír); Trávníček, Z.; Cankař, P.

2014-01-01

A regioselective synthesis of dihydropyrazolo[1,5-a]pyrimidines is reported. The multicomponent reaction of readily available arylaldehydes, Meldrum's acid, and aminopyrazole CAN508 afforded fused pyrazolopyrimidines in high yields. The reaction proceeded regioselectively via initial Michael addition of the exocyclic amino group to arylidene Meldrum's acid intermediate followed by a ring closure at the endocyclic nitrogen of aminopyrazole. The regioselectivity of the reaction was determined b...

Hydrogen embrittlement of ASTM A 203 D nuclear structural steel

International Nuclear Information System (INIS)

Chakravartty, J.K.; Prasad, G.E.; Sinha, T.K.; Asundi, M.K.

1986-01-01

The influence of hydrogen on the mechanical properties of ASTM A 203 D nuclear structural steel has been studied by tension, bend and delayed-failure tests at room temperature. While the tension tests of hydrogen charged unnotched specimens reveal no change in ultimate strength and ductility, the effect of hydrogen is manifested in notched specimens (tensile and bend) as a decrease in ultimate strength (maximum load in bend test) and ductility; the effect increases with increasing hydrogen content. It is observed that for a given hydrogen concentration, the decrease in bend ductility is remarkably large compared to that in tensile ductility. Hydrogen charging does not cause any delayed-failure upto 200 h under an applied tensile stress, 0.85 times the notch tensile strength. However delayed failure occurs in hydrogen charged bend samples in less than 10 h under an applied bending load of about 0.80 times of the uncharged maximum load. Fractographs of hydrogen charged unnotched specimens show ductile dimple fracture, while those of notched tension and bend specimens under hydrogen-charged conditions show a mixture of ductile dimple and quasi-cleavage cracking. The proportion of quasi-cleavage cracking increases with increasing hydrogen content and this fracture mode is more predominant in bend specimens. The changes in tensile properties and fracture modes can reasonably be explained by existing theories of hydrogen embrittlement. An attempt is made to explain the significant difference in the embrittlement susceptibility of bend and tensile specimens in the light of difference in triaxiality and plastic zone size near the notch tip. (orig.)

Dynamic fracture toughness of ASME SA508 Class 2a ASME SA533 grade A Class 2 base and heat affected zone material and applicable weld metals

International Nuclear Information System (INIS)

Logsdon, W.A.; Begley, J.A.; Gottshall, C.L.

1978-03-01

The ASME Boiler and Pressure Vessel Code, Section III, Article G-2000, requires that dynamic fracture toughness data be developed for materials with specified minimum yield strengths greater than 50 ksi to provide verification and utilization of the ASME specified minimum reference toughness K/sub IR/ curve. In order to qualify ASME SA508 Class 2a and ASME SA533 Grade A Class 2 pressure vessel steels (minimum yield strengths equal 65 kip/in. 2 and 70 kip/in. 2 , respectively) per this requirement, dynamic fracture toughness tests were performed on these materials. All dynamic fracture toughness values of SA508 Class 2a base and HAZ material, SA533 Grade A Class 2 base and HAZ material, and applicable weld metals exceeded the ASME specified minimum reference toughness K/sub IR/ curve

The fatigue-crack propagation behavior of ASTM A533-B steel tested in vacuo at LWR operating temperatures

International Nuclear Information System (INIS)

James, L.A.

1987-01-01

The fatigue-crack propagation (FCP) behavior of ASTM A533-B-1 steel was characterized in vacuo at 288 0 C. Tests were conducted at two stress ratios: R = 0.05 and R = 0.7. Results of these tests were compared with results from previous studies for the same type of steel tested in an air environment, and FCP rates in vacuo were generally lower than those in air. Stress ratio effects in vacuo were not as great as those in air, and both stress ratio effects and environmental effects are discussed from the standpoint of crack closure concepts

Modeling flow stress constitutive behavior of SA508-3 steel for nuclear reactor pressure vessels

International Nuclear Information System (INIS)

Sun Mingyue; Hao Luhan; Li Shijian; Li Dianzhong; Li Yiyi

2011-01-01

Highlights: → A series of flow stress constitutive equations for SA508-3 steel were successfully established. → The experimental results under different conditions have validated the constitutive equations. → An industrial application of the model was present to simulate a large conical shell forging process. - Abstract: Based on the measured stress-strain curves under different temperatures and strain rates, a series of flow stress constitutive equations for SA508-3 steel were firstly established through the classical theories on work hardening and softening. The comparison between the experimental and modeling results has confirmed that the established constitutive equations can correctly describe the mechanical responses and microstructural evolutions of the steel under various hot deformation conditions. We further represented a successful industrial application of this model to simulate a forging process for a large conical shell used in a nuclear steam generator, which evidences its practical and promising perspective of our model with an aim of widely promoting the hot plasticity processing for heavy nuclear components of fission reactors.

Study of radiation damage of steels for light water pressure vessels at UJV

International Nuclear Information System (INIS)

Vacek, N.; Stoces, B.

1980-01-01

Preoperational determination of radiation resistance of pressure vessel steels is performed at accelerated neutron exposure in a test or materials research reactor. The results obtained at accelerated and operating exposure are not fully identical and surveillance bodies are therefore used manufactured from the pressure vessel material. Currently, the following steels are used for the manufacture of light water reactor pressure vessels: Mn-Mo-Ni (ASTM-A533-B, ASTM-A508), Cr-Mo-V (15Kh2M1FA). At UJV Rez, for irradiation Chanca-M probes imported from France are used featuring electric temperature control. Almost identical radiation embrittlement was measured for all three steels after irradiation with a neutron fluence of 3x10 23 n.m -2 at a temperature of 290 degC. (H.S.)

46 CFR 508.101 - Cross-referrence to employee ethical conduct standards and financial disclosure regulations.

Science.gov (United States)

2010-10-01

... 46 Shipping 9 2010-10-01 2010-10-01 false Cross-referrence to employee ethical conduct standards... GENERAL AND ADMINISTRATIVE PROVISIONS EMPLOYEE ETHICAL CONDUCT STANDARDS AND FINANCIAL DISCLOSURE REGULATIONS § 508.101 Cross-referrence to employee ethical conduct standards and financial disclosure...

An Experimental Copyright Moratorium: Study of a Proposed Solution to the Copyright Photocopying Problem. Final Report to the American Society for Testing and Materials (ASTM).

Science.gov (United States)

Heilprin, Laurence B.

The Committee to Investigate Copyright Problems (CICP), a non-profit organization dedicated to resolving the conflict known as the "copyright photocopying problem" was joined by the American Society for Testing and Materials (ASTM), a large national publisher of technical and scientific standards, in a plan to simulate a long-proposed…

Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma

International Nuclear Information System (INIS)

Zhai, Qingna; Zhou, Liang; Zhao, Chunjuan; Wan, Jun; Yu, Zhendong; Guo, Xin; Qin, Jie; Chen, Jing; Lu, Ruijing

2012-01-01

Highlights: ► Previous method was the second-generation sequencing technology. ► miR-508-3p and miR-509-3p were significantly down-regulated in RCC tissues. ► They can inhibit cell proliferation and migration and promote cell apoptosis. ► The expression of miR-508-3p was significantly decreased in RCC patients plasma. ► miR-508-3p may be a novel diagnostic marker of RCC. -- Abstract: MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC.

Determination of ASTM 1016 structural welded joints fracture toughness through J integral

International Nuclear Information System (INIS)

Martins, Geraldo de Paula; Villela, Jefferson Jose; Terra, Jose Lucio; Rabello, Emerson Giovani; Martins, Geraldo Antonio Scoralick; Carneiro, Jose Rubens Goncalves

2009-01-01

Fracture toughness is an important parameter for studies of materials behavior in nuclear and conventional industry. Crack propagation resistance is, in general, evaluate using one of the fracture mechanics parameters K IC , for the case of the materials that exhibits a linear elastic behavior, the CTOD (crack tip opening displacement) and J IC , the critical value of J Integral, for the case of materials with elastic-plastic behavior. On this work the fracture mechanics parameters of the ASTM 1016 structural steel welded joints were obtained, using the J Integral. Charpy V tests at several temperatures were also obtained, with the purpose to obtain the curves of ductile-brittle of the regions of the welded joints: Base Metal, (MB), and Melted Zone (MZ). The joints were welded by Gas Metal Arc Welding (GMAW) with V bevel for evaluation the MZ toughness properties. The tests were accomplished at temperatures varying from -100 deg C to 100 deg C using the technical of compliance variation for J IC determination, the critical value that defines the initial stable crack growth, that applies to brittle and ductile materials. The J Integral alternative specimens has square cross section 10mmX10mm, according ASTM E 1820, with notch localized respectively at the BM and MZ. After the tests, the specimens fractured were analyzed in a scanning microscopic electronic (SME) for verification of the fracture surface. The fractography of the specimens at elevated temperatures presented dimples at the region of stable crack growth, characteristic of ductile fracture. The results of J Integral and Charpy V presented a good correlation between these two parameters. From these correlations it can be concluded that in some applications, the use Charpy V energy to infer fracture toughness can be substitute the Integral J tests. (author)

Application of ASTM E-1559 Apparatus to Study H2O Desorption

Science.gov (United States)

Woronowicz, Michael; Perry, Radford, III; Meadows, George A.

2015-01-01

The NASA James Webb Space Telescope project identified a need to measure water vapor desorption from cryogenic surfaces in order to validate predictions of spacecraft design performance. A review of available scientific literature indicated no such measurements had been reported below 131 K. Contamination control personnel at NASA Goddard Space Flight Center recognized the possibility they readily possessed the means to collect these measurements at lower temperatures using an existing apparatus commonly employed for making outgassing observations. This presentation will relate how the ASTM E-1559 Molekit apparatus was used without physical modification to measure water vapor sublimation down to 120 K and compare this data to existing equilibrium vapor pressure models.

Correção simultânea de defeito congênito intracardíaco e pectus excavatum Simultaneous repair of congenital heart defect and pectus excavatum

Directory of Open Access Journals (Sweden)

João Roberto Breda

2007-09-01

Full Text Available Relatamos tratamento simultâneo de pectus excavatum e defeito congênito intracardíaco representado por comunicação interatrial ostium secundum. Paciente do sexo masculino, 8 anos de idade, com diagnóstico clínico e ecocardiográfico de comunicação interatrial, associada à deformidade da parede torácica tipo pectus excavatum. Foi encaminhado para operação com correção simultânea do defeito congênito intracardíaco associado ao reparo do pectus. O tratamento operatório simultâneo do pectus excavatum e defeitos congênitos intracardíacos torna difícil o acesso ao coração. Foi feita a correção simultânea dessas alterações, com satisfatório resultado, sobretudo estético, para o paciente.The author describes the simultaneous treatment of pectus excavatum and congenital intracardiac defect (atrial septal defect represented by the interatrial foramen secundum. An 8-year-old boy, with clinical and echocardiography diagnosis of atrial septal defect associated with pectus excavatum was referred to a simultaneous surgical treatment of both abnormalities. The simultaneous surgical treatment of both pectus excavatum and congenital intracardiac defects make it difficult to access the heart. In this case, the simultaneous surgical treatment of atrial septal defect and pectus excavatum was a valuable alternative to surgical repair of both abnormalities, mainly due to its cosmetic outcome.

Mobile Robot and Mobile Manipulator Research Towards ASTM Standards Development.

Science.gov (United States)

Bostelman, Roger; Hong, Tsai; Legowik, Steven

2016-01-01

Performance standards for industrial mobile robots and mobile manipulators (robot arms onboard mobile robots) have only recently begun development. Low cost and standardized measurement techniques are needed to characterize system performance, compare different systems, and to determine if recalibration is required. This paper discusses work at the National Institute of Standards and Technology (NIST) and within the ASTM Committee F45 on Driverless Automatic Guided Industrial Vehicles. This includes standards for both terminology, F45.91, and for navigation performance test methods, F45.02. The paper defines terms that are being considered. Additionally, the paper describes navigation test methods that are near ballot and docking test methods being designed for consideration within F45.02. This includes the use of low cost artifacts that can provide alternatives to using relatively expensive measurement systems.

Tumores cardíacos: 10 anos de experiência

Directory of Open Access Journals (Sweden)

Antônio Augusto MIANA

1997-01-01

Full Text Available Objetivo: Avaliar a experiência cirúrgica do grupo no tratamento dos tumores cardíacos durante o período de janeiro de 1985 a dezembro de 1994. Casuística e Métodos: De um total de 2268 cirurgias cardíacas com circulação extracorpórea realizadas neste período de 10 anos, 6 foram para extirpação de tumores intracavitários, perfazendo 0,26% dos casos. Destes, 3 eram mixomas de átrio esquerdo, 1 fibroelastoma papilar de valva mitral, 1 rabdomioma de ventrículo esquerdo e 1 fibroma de ventrículo esquerdo. A forma clínica de apresentação foi embolia sistêmica (3 casos ou insuficiência cardíaca (3 casos. O diagnóstico foi ecocardiográfico (5 casos e angiográfico (6 casos. Resultados: Todos os pacientes tiveram evolução imediata favorável, exceto 1 deles, com mixoma de átrio equerdo, que evoluiu com mediastinite e septicemia, vindo a falecer e constituindo o único óbito hospitalar. O seguimento pós-operatório tardio, obtido em 4 pacientes (15 a 111 meses - média 49 ± 36,8 meses, não detectou qualquer recidiva, encontrando-se todos em classe funcional I (NYHA. Conclusões: Os autores concluem que os tumores cardíacos são bastante raros, de fácil diagnóstico desde que considerados, na grande maioria benignos e que cursam favoravelmente com a extirpação cirúrgica.Purpose: To review the surgical experience of our group in the treatment of primary cardiac tumors, during a 10 year period beginning January 1985 till December 1994. Material and Methods: From a total of 2268 cardiac surgeries with the aid of extracorporeal circulation performed during this 10 year period, there were 6 cases of intracavitary tumor resection, an incidence of 0.26%. Three were myxomas of the left atrium, 1 papillary fibroelastoma of the mitral valve, 1 rhabdomyoma of the left ventricule and 1 fibroma of the left ventricle. Three patients presented systemic embolism and the other three congestive heart failure. The diagnosis was confirmed

Empirical ranking of a wide range of WC-Co grades in terms of their abrasion resistance measured by the ASTM standard B 611-85 test

CSIR Research Space (South Africa)

O'Quigley, DGF

1997-01-01

Full Text Available This paper reports the results of a comprehensive investigation into the abrasion resistance of WC-Co alloys, as measured by the ASTM Standard B 611-85 test. The alloys ranged from 3 to 50 wt% and from 0.6 to 5 mu-m average grain size. Careful...

ASTM and VAMAS activities in titanium matrix composites test methods development

Science.gov (United States)

Johnson, W. S.; Harmon, D. M.; Bartolotta, P. A.; Russ, S. M.

1994-01-01

Titanium matrix composites (TMC's) are being considered for a number of aerospace applications ranging from high performance engine components to airframe structures in areas that require high stiffness to weight ratios at temperatures up to 400 C. TMC's exhibit unique mechanical behavior due to fiber-matrix interface failures, matrix cracks bridged by fibers, thermo-viscoplastic behavior of the matrix at elevated temperatures, and the development of significant thermal residual stresses in the composite due to fabrication. Standard testing methodology must be developed to reflect the uniqueness of this type of material systems. The purpose of this paper is to review the current activities in ASTM and Versailles Project on Advanced Materials and Standards (VAMAS) that are directed toward the development of standard test methodology for titanium matrix composites.

Controlling‏ ‏the Balance of Exploration and ‎Exploitation in ACO Algorithm ‎

Directory of Open Access Journals (Sweden)

Ayad ‎ Mohammed Jabbar

2018-02-01

Full Text Available Ant colony optimization is a meta-heuristic algorithm inspired by the foraging behavior of real ant colony. The algorithm is a population-based solution employed in different optimization problems such as classification, image processing, clustering, and so on. This paper sheds the light on the side of improving the results of traveling salesman problem produced by the algorithm. The key success that produces the valuable results is due to the two important components of exploration and exploitation. Balancing both components is the foundation of controlling search within the ACO. This paper proposes to modify the main probabilistic method to overcome the drawbacks of the exploration problem and produces global optimal results in high dimensional space. Experiments on six variant of ant colony optimization indicate that the proposed work produces high-quality results in terms of shortest route

Inter-dependence of the electron beam excitations with the free electron laser stability on the super-ACO storage ring

CERN Document Server

Couprie, Marie Emmanuelle; Nutarelli, D; Renault, E; Billardon, M

1999-01-01

Storage ring free electron lasers have a complex dynamics as compared to the LINAC driven FEL sources since both the laser and the recirculating electron beam behaviours are involved. Electron beam perturbations can strongly affect the FEL operation (start-up, stability) whereas the FEL can stabilize beam instabilities. Experimental analysis together with simulations are reported here. Improvements of the Super-ACO FEL for users is discussed, and consequences are given in terms of electron beam tolerances for a source development for users.

Tekken testing to determine the preheating temperature on ASTM A514 GR B steel

International Nuclear Information System (INIS)

Asta, Eduardo; Zalazar, Monica; Quesada, Hector

2003-01-01

The cold cracking test methods are used to determine the preheating temperature in order to avoid cracking in steel welding.In this work Tekken tests on high strength quenching and tempering (ASTM A514 GrB) structural steel with a thickness of 25 mm have been made.The welds were done using a FCAW process with gas shielding and basic low hydrogen cored wire E 110T5-K4.The welding parameters and joint design applied in this work are similar to the ones used on site production.The base metal, HAZ and weld metal microstructure have been evaluated by optical and SEM microscopy.Thermal cycles records of each welding have been made to relate preheat temperature with the cooling time on the range of 800-500 degC (t8/5) or 800-100degC (t8/1) and the evidence of crack or no crack condition.Finally, a preheat temperature of 150degC and the cooling time larger than 17 s improve a welding integrity without cracks

Cerebral physiology and preservation during cardiac arrest Fisiología y preservación cerebral durante el paro cardíaco: vulnerabilidad del cerebro

Directory of Open Access Journals (Sweden)

Luis M. Gómez

1991-03-01

Full Text Available

Cerebral physiology during cardiac arrest is discussed with particular Interest on selective neuronal damage. Previous concepts on brain tolerance to hypoxia are analyzed and new information about brain function prognosis after cardiac arrest is presented. Therapeutic alternatives for brain preservation are discussed with emphasis on the lack of effectiveness of barbiturates, the results of research with other drugs and the future role that blockers of excitatory neurotransmission may have as elements of cerebral preservation.

Se hace una aproximación a la fisiología cerebral durante el paro cardíaco, destacando el concepto de darlo neuronal selectivo. Se presentan elementos que permiten modificar concepciones antiguas sobre la tolerancia del cerebro a la hipoxia severa. Además, se hace un nuevo planteamiento sobre el pronóstico cerebral luego de un paro cardíaco y se esbozan las alternativas terapéuticas utilizadas hasta la fecha para la preservación cerebral. Se hace énfasis en la inefectividad de los barbitúricos, en la investigación sobre la terapia con otras drogas y en el futuro abierto hacia los bloqueadores de los neurotransmisores excitadores, como elementos terapéuticos para la preservación cerebral.

Measurements by a Vector Network Analyzer at 325 to 508 GHz

Science.gov (United States)

Fung, King Man; Samoska, Lorene; Chattopadhyay, Goutam; Gaier, Todd; Kangaslahti, Pekka; Pukala, David; Lau, Yuenie; Oleson, Charles; Denning, Anthony

2008-01-01

Recent experiments were performed in which return loss and insertion loss of waveguide test assemblies in the frequency range from 325 to 508 GHz were measured by use of a swept-frequency two-port vector network analyzer (VNA) test set. The experiments were part of a continuing effort to develop means of characterizing passive and active electronic components and systems operating at ever increasing frequencies. The waveguide test assemblies comprised WR-2.2 end sections collinear with WR-3.3 middle sections. The test set, assembled from commercially available components, included a 50-GHz VNA scattering- parameter test set and external signal synthesizers, augmented with recently developed frequency extenders, and further augmented with attenuators and amplifiers as needed to adjust radiofrequency and intermediate-frequency power levels between the aforementioned components. The tests included line-reflect-line calibration procedures, using WR-2.2 waveguide shims as the "line" standards and waveguide flange short circuits as the "reflect" standards. Calibrated dynamic ranges somewhat greater than about 20 dB for return loss and 35 dB for insertion loss were achieved. The measurement data of the test assemblies were found to substantially agree with results of computational simulations.

Standard test method for compressive strength of grouts for preplaced-aggregate concrete in the laboratory. ASTM standard

International Nuclear Information System (INIS)

1998-10-01

DoD adopted. This test method is under the jurisdiction of ASTM Committee C-9 on Concrete and Concrete Aggregates and is the direct responsibility of Subcommittee C09.41 on Concrete for Radiation Shielding. Current edition approved Feb. 10, 1986 and published October 1998. Originally published as C 942-81. Last previous edition was C 942-86(1991)

Standard test method for static leaching of monolithic waste forms for disposal of radioactive waste. ASTM standard

International Nuclear Information System (INIS)

1998-10-01

This test method is under the jurisdiction of ASTM Committee C-26 on Nuclear Fuel Cycles and is the direct responsibility of Subcommittee C26.07 on Waste Materials. The current edition was approved July 10, 1998, and published in October 1998. It was originally published as C 1220-92. The last previous edition was C 1220-92

Débito cardíaco diminuído: revisão sistemática das características definidoras Débito cardíaco disminuído: revisión sistemática de las características definidoras Decreased cardiac output: a systematic review of the defining characteristics

Directory of Open Access Journals (Sweden)

Vanessa de Souza

2011-01-01

Full Text Available OBJETIVOS: Caracterizar os artrigos científicos relacionados ao diagnóstico de enfermagem débito cardíaco diminuído. Verificar os artigos que descrevem o comportamento das características definidoras deste diagnóstico, identificando aquelas que ocorrem com maior frequência. MÉTODOS: Trata-se de uma revisão sistemática realizada nas bases de dados: Lilacs, SciELO, Embase, Medline, Pubmed e Cochrane, no período de 1985 a 2008. RESULTADOS: Foram selecionados 13 artigos, identificando 50 características definidoras, sendo dez com maior frequência: alteração da frequência/ritmo cardíaco, dispneia, labilidade da pressão arterial, estertores, oligúria anúria, edema, pele fria, fadiga/fraqueza, diminuição dos pulsos periféricos e diminuição da perfusão periférica. CONCLUSÃO: A temática vem sendo pouco explorada. Constatou-se a importância do exame físico, a utilização de técnicas menos invasivas e a necessidade de rever as características definidoras propostas a fim de proporcionar clareza e objetividade na identificação desse diagnóstico de enfermagemOBJETIVOS: Caracterizar los artículos científicos relacionados al diagnóstico de enfermería débito cardíaco disminuído. Verificar los artículos que describen el comportamiento de las características definidoras de este diagnóstico, identificando aquellas que ocurren con mayor frecuencia. MÉTODOS: Se trata de una revisión sistemática realizada en las bases de datos: Lilacs, SciELO, Embase, Medline, Pubmed y Cochrane, en el período de 1985 al 2008. RESULTADOS: Fueron seleccionados 13 artículos, identificando 50 características definidoras, siendo diez con mayor frecuencia: alteración de la frecuencia/ritmo cardíaco, disnea, labilidad de la presión arterial, estertores, oliguria anuria, edema, piel fría, fatiga/debilidad, disminución de los pulsos periféricos y disminución de la perfusión periférica. CONCLUSIÓN: La temática viene siendo poco

Corrosion resistant properties and weldabilities of ASTM Grade 12 titanium alloy

International Nuclear Information System (INIS)

Tsumori, Yoshikatsu; Itoh, Hideo

1988-01-01

Plates, sheets, bars, wires and thinner seam-welded tubings were manufactured from large-scaled ingot of ASTM Grade 12 alloy (Ti-0.8Ni-0.3Mo). The processability of G-12 alloy has proved almost similar to that of conventional commercially pure titanium grades. It has been clarified that the G-12 alloy showed several advantageous features: Chlorides-Crevice corrosion resistance of the alloy was almost equals to G-7 and Pd0/TiO 2 coated titanium, and the maximum allowable stress was able to be designed higher than that of commercially pure titanium. This alloy has been in applications also offers where such environments as seawater, brines and moist chlorine, various oil refinery and chemical industries, and others. (author)

Perfil dos pacientes na Lista Única de Espera para transplante cardíaco no estado do Ceará Perfil de los pacientes en la lista única de espera para transplante cardíaco en el estado de Ceará Profile of patients in the Unified Waiting List for heart transplantation in state of Ceará

Directory of Open Access Journals (Sweden)

Francisca Elisângela Teixeira Lima

2010-07-01

Full Text Available FUNDAMENTO: Os transplantes de órgãos têm aumentado consideravelmente nos últimos anos em razão da evolução tecnológica e da sensibilização da sociedade para doação de órgãos. OBJETIVO: Descrever as características dos pacientes da Lista Única de Espera para transplante cardíaco; identificar as principais cardiopatias; e verificar o tempo médio de permanência do paciente na Lista até a realização da cirurgia. MÉTODOS: Trata-se de um estudo descritivo, documental e retrospectivo, com abordagem quantitativa, desenvolvido na Central de Transplante do Estado do Ceará, com 156 pacientes incluídos na Lista Única de Espera do ano de 1999 a 2006. Os dados foram organizados em figuras. RESULTADOS: Foram encontrados: 81% do sexo masculino; 22,4% adultos jovens (20 a 40 anos e 56,4% adultos de meia-idade (40 a 64 anos, com uma média de 36 anos; 79% procedentes de Fortaleza-CE; 91% tinham miocardiopatia como causa do transplante cardíaco. Dentre esses pacientes 102 (69% foram transplantados; 37 (25% evoluíram para óbito antes do transplante e 8 (6% foram excluídos por melhora ou piora do quadro clínico. CONCLUSÃO: Os pacientes da Lista Única de Espera para transplante cardíaco no Estado do Ceará, no período de 1999 a 2006, eram do sexo masculino (80%, com faixa etária variando de 1 a 71 anos, com predomínio da miocardiopatia dilatada (53,4%, e o tempo médio de espera foi de 136 dias até o dia do transplante cardíaco.FUNDAMENTO: Los transplantes de órganos han aumentado considerablemente en los últimos años, en razón de la evolución tecnológica y de la sensibilización de la sociedad para la donación de órganos. OBJETIVO: Describir las características de los pacientes de la Lista Única de Espera para transplante cardíaco; identificar las principales cardiopatías; y verificar el tiempo medio de permanencia del paciente en la Lista hasta la realización de la cirugía. MÉTODOS: Se trata de un estudio

Refinement of grain structure in 20 MnNiMo (SA508C) steel

International Nuclear Information System (INIS)

Sheng Zhongqi; Xiao Hong; Peng Feng; Zou Min

1997-04-01

The size of prior austenite grains and bainitic colonies of 20 MnNiMo (SA508C) steel (a reactor pressure vessel steel) after normal heat treatment is measured and its controlling factors are discussed. Results show that low aluminium content can induce serious mixed structure with fine and coarse grains in prior austenite. Fast cooling rate can promote refinement of bainitic colonies. Further refinement of grains can be obtained by inter-critical quenching. (5 figs., 1 tab.)

Assessment of wrought ASTM F1058 cobalt alloy properties for permanent surgical implants.

Science.gov (United States)

Clerc, C O; Jedwab, M R; Mayer, D W; Thompson, P J; Stinson, J S

1997-01-01

The behavior of the ASTM F1058 wrought cobalt-chromium-nickel-molybdenum-iron alloy (commonly referred to as Elgiloy or Phynox) is evaluated in terms of mechanical properties, magnetic resonance imaging, corrosion resistance, and biocompatibility. The data found in the literature, the experimental corrosion and biocompatibility results presented in this article, and its long track record as an implant material demonstrate that the cobalt superalloy is an appropriate material for permanent surgical implants that require high yield strength and fatigue resistance combined with high elastic modulus, and that it can be safely imaged with magnetic resonance.

Fatigue crack propagation in neutron-irradiated ferritic pressure-vessel steels

International Nuclear Information System (INIS)

James, L.A.

1977-01-01

The results of a number of experiments dealing with fatigue crack propagation in irradiated reactor pressure-vessel steels are reviewed. The steels included ASTM alloys A302B, A533B, A508-2, and A543, as well as weldments in A543 steel. Fluences and irradiation conditions were generally typical of those experienced by most power reactors. In general, the effect of neutron irradiation on the fatigue crack propagation behavior of these steels was neither significantly beneficial nor significantly detrimental

ASTM E 1559 method for measuring material outgassing/deposition kinetics has applications to aerospace, electronics, and semiconductor industries

Science.gov (United States)

Garrett, J. W.; Glassford, A. P. M.; Steakley, J. M.

1994-01-01

The American Society for Testing and Materials has published a new standard test method for characterizing time and temperature-dependence of material outgassing kinetics and the deposition kinetics of outgassed species on surfaces at various temperatures. This new ASTM standard, E 1559(1), uses the quartz crystal microbalance (QCM) collection measurement approach. The test method was originally developed under a program sponsored by the United States Air Force Materials Laboratory (AFML) to create a standard test method for obtaining outgassing and deposition kinetics data for spacecraft materials. Standardization by ASTM recognizes that the method has applications beyond aerospace. In particular, the method will provide data of use to the electronics, semiconductor, and high vacuum industries. In ASTM E 1559 the material sample is held in vacuum in a temperature-controlled effusion cell, while its outgassing flux impinges on several QCM's which view the orifice of the effusion cell. Sample isothermal total mass loss (TML) is measured as a function of time from the mass collected on one of the QCM's which is cooled by liquid nitrogen, and the view factor from this QCM to the cell. The amount of outgassed volatile condensable material (VCM) on surfaces at higher temperatures is measured as a function of time during the isothermal outgassing test by controlling the temperatures of the remaining QCM's to selected values. The VCM on surfaces at temperatures in between those of the collector QCM's is determined at the end of the isothermal test by heating the QCM's at a controlled rate and measuring the mass loss from the end of the QCM's as a function of time and temperature. This reevaporation of the deposit collected on the QCM's is referred to as QCM thermogravimetric analysis. Isothermal outgassing and deposition rates can be determined by differentiating the isothermal TML and VCM data, respectively, while the evaporation rates of the species can be obtained as a

Assessing the Library Homepages of COPLAC Institutions for Section 508 Accessibility Errors: Who's Accessible, Who's Not, and How the Online WebXACT Assessment Tool Can Help

Science.gov (United States)

Huprich, Julia; Green, Ravonne

2007-01-01

The Council on Public Liberal Arts Colleges (COPLAC) libraries websites were assessed for Section 508 errors using the online WebXACT tool. Only three of the twenty-one institutions (14%) had zero accessibility errors. Eighty-six percent of the COPLAC institutions had an average of 1.24 errors. Section 508 compliance is required for institutions…

Lack of effect of delta F508 mutation on aerobic capacity in patients with cystic fibrosis.

Science.gov (United States)

Kaplan, T A; Moccia-Loos, G; Rabin, M; McKey, R M

1996-10-01

As aerobic exercise capacity, as defined by VO2max, is associated with patient functioning and possibly prognosis in cystic fibrosis (CF), correlations between VO2max phenotype and genotype may be of value. Retrospective clinical series. Cystic fibrosis referral clinic. Convenience sample of 35 patients with CF consecutively referred for exercise testing. Blood samples were examined for mutations of cystic fibrosis transmembrane regulator (CFTR), Height, wight, pulmonary function, resting-energy expenditure, VO2max, and other exercise variables were assessed in each referred patient. Statistical comparison of 10 patients who were homozygous for the dF508 mutation of CFTR with 20 patients heterozygous for dF508 revealed no significant differences for height, weight, pulmonary function, resting-energy expenditure, VO2max, or any other exercise variables. These results imply a limited effect of the mutation status on overall patient functioning and prognosis. Future identification of more rare CFTR mutations and other genes and subsequent classification of patients in a manner reflective of the cellular physiology may lead to different results.

ASTM Committee C28: International Standards for Properties and Performance of Advanced Ceramics-Three Decades of High-Quality, Technically-Rigorous Normalization

Science.gov (United States)

Jenkins, Michael G.; Salem, Jonathan A.

2016-01-01

Physical and mechanical properties and performance of advanced ceramics and glasses are difficult to measure correctly without the proper techniques. For over three decades, ASTM Committee C28 on Advanced Ceramics, has developed high-quality, technically-rigorous, full-consensus standards (e.g., test methods, practices, guides, terminology) to measure properties and performance of monolithic and composite ceramics that may be applied to glasses in some cases. These standards contain testing particulars for many mechanical, physical, thermal, properties and performance of these materials. As a result these standards are used to generate accurate, reliable, repeatable and complete data. Within Committee C28, users, producers, researchers, designers, academicians, etc. have written, continually updated, and validated through round-robin test programs, 50 standards since the Committee's founding in 1986. This paper provides a detailed retrospective of the 30 years of ASTM Committee C28 including a graphical pictogram listing of C28 standards along with examples of the tangible benefits of standards for advanced ceramics to demonstrate their practical applications.

ASTM Committee C28: International Standards for Properties and Performance of Advanced Ceramics, Three Decades of High-quality, Technically-rigorous Normalization

Science.gov (United States)

Jenkins, Michael G.; Salem, Jonathan A.

2016-01-01

Physical and mechanical properties and performance of advanced ceramics and glasses are difficult to measure correctly without the proper techniques. For over three decades, ASTM Committee C28 on Advanced Ceramics, has developed high quality, rigorous, full-consensus standards (e.g., test methods, practices, guides, terminology) to measure properties and performance of monolithic and composite ceramics that may be applied to glasses in some cases. These standards testing particulars for many mechanical, physical, thermal, properties and performance of these materials. As a result these standards provide accurate, reliable, repeatable and complete data. Within Committee C28 users, producers, researchers, designers, academicians, etc. have written, continually updated, and validated through round-robin test programs, nearly 50 standards since the Committees founding in 1986. This paper provides a retrospective review of the 30 years of ASTM Committee C28 including a graphical pictogram listing of C28 standards along with examples of the tangible benefits of advanced ceramics standards to demonstrate their practical applications.

Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del.

Science.gov (United States)

Taylor-Cousar, Jennifer L; Munck, Anne; McKone, Edward F; van der Ent, Cornelis K; Moeller, Alexander; Simard, Christopher; Wang, Linda T; Ingenito, Edward P; McKee, Charlotte; Lu, Yimeng; Lekstrom-Himes, Julie; Elborn, J Stuart

2017-11-23

Combination treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target the underlying cause of disease in patients with cystic fibrosis. In this phase 3, randomized, double-blind, multicenter, placebo-controlled, parallel-group trial, we evaluated combination therapy with tezacaftor and ivacaftor in patients 12 years of age or older who had cystic fibrosis and were homozygous for the CFTR Phe508del mutation. Patients were randomly assigned in a 1:1 ratio to receive either 100 mg of tezacaftor once daily and 150 mg of ivacaftor twice daily or matched placebo for 24 weeks. The primary end point was the absolute change in the percentage of the predicted forced expiratory volume in 1 second (FEV 1 ) through week 24 (calculated in percentage points); relative change in the percentage of the predicted FEV 1 through week 24 (calculated as a percentage) was a key secondary end point. Of the 510 patients who underwent randomization, 509 received tezacaftor-ivacaftor or placebo, and 475 completed 24 weeks of the trial regimen. The mean FEV 1 at baseline was 60.0% of the predicted value. The effects on the absolute and relative changes in the percentage of the predicted FEV 1 in favor of tezacaftor-ivacaftor over placebo were 4.0 percentage points and 6.8%, respectively (Pcystic fibrosis and were homozygous for the CFTR Phe508del mutation. (Funded by Vertex Pharmaceuticals; EVOLVE ClinicalTrials.gov number, NCT02347657 .).

Utilização de valvas homólogas e heterólogas em condutos extracardíacos The use of homograph and heterograph valves in extracardiac conduits

Directory of Open Access Journals (Sweden)

Rui Siqueira de Almeida

1988-08-01

Full Text Available O conceito do uso de um conduto extracardíaco para estabelecer uma via de saída, conectando o ventrículo direito com o tronco pulmonar, ou seus ramos, foi desenvolvido na década de 60. Entre 1971 e 1986, 335 pacientes receberam, no The Hospital for Sick Children, de Londres, condutos extracardíacos para o lado direito do coração; 176 destes foram homoenxertos aórticos, preservados em solução antibióticonutriente; 140 heteroenxertos (Hancock, Ross, Carpentier-Edwards, lonescu-Shiley e 19 tubos não valvulados. Estes condutos foram usados na correção de defeitos cardíacos complexos. A idade média foi de 6,34 anos e o peso médio, de 17,8 kg. O diâmetro interno dos condutos variou de 8 a 30 mm. A mortalidade hospitalar foi de 29,2% e o seguimento dos sobrevivente teve uma duração máxima de 14,3 anos, sendo que apenas 40% delas foram relacionadas ao conduto extracardíaco. A curva atuarial, livre de obstrução, dos condutos extracardíacos foi significativa, quando se analisaram os homoenxertos, face a cada grupo de heteroenxertos (p The concept of using extracardiac conduits, to establish an outflow tract between the right ventricle and the pulmonary artery was developed on the sixties. Between 1971 and 1986, 335 patients received extracardiac conduits for the right heart, at The Hospital for Sick Children, London; 176 were antibiotic preserved aortic homografts (Hancock, Ross, Carpentier-Edwards, lonescu-Shiley and 19 non-valved tubes. These conduits were used for the repair of complex congenital heart defects. The mean age of these groups was 6.34 ± 4.6 years and the mean weight 17.8 ± 10.8 kg. The internal diameter of the conduits varied from 8 to 30 mm. The hospital mortality was 29.2% and long-term follow-up of the survivals had a maximum period of 14,39 years. Sixty patients (17.9% were submited to 60 reoperations, being only 40% conduit related. The actuarial survival cun/e of freedom from obstruction was significant

Welding metallurgy of SA508 Cl II heat affected zones

International Nuclear Information System (INIS)

Alberry, P.J.; Lambert, J.A.

1982-01-01

A weld thermal simulation technique has been used to investigate the metallurgical response of SA508 class II material during welding. Dynamic Ac 1 and Ac 3 data, grain growth kinetics and continuous cooling transformation diagrams have been measured. The heat affected zone structure, grain size and precipitate distribution are described in terms of the weld thermal cycle experienced and compared with a weld heat affected zone. The as-welded hardness and tempering response of a range of possible heat affected zone structures has been established. The tempering effects of various weld thermal cycles are calculated from isothermal tempering data. The likely tempering effects during welding are estimated and compared with the tempering of actual welds during welding and in subsequent conventional post weld heat treatment. 16 figures, 6 tables

Treinamento físico de natação promove remodelamento cardíaco e melhora a perfusão sanguínea no músculo cardíaco de SHR via mecanismo dependente de adenosina

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Juliana Gonçalves de Barros

2011-06-01

Full Text Available INTRODUÇÃO: Exercícios físicos são utilizados como terapia não farmacológica para o tratamento da hipertensão arterial, e o treinamento físico (TF por natação é reconhecido por produzir remodelamento cardíaco em animais experimentais. Entretanto, a ação vasodilatadora da adenosina (ado resultante do exercício físico como prevenção e tratamento da hipertensão é pouco explorada. OBJETIVO: Avaliar o remodelamento cardíaco e o papel da adenosina na distribuição do fluxo sanguíneo para o miocárdio após treinamento físico em SHR. Método: 28 SHR machos babies e adultos foram submetidos ao TF aeróbio de natação, durante 10 semanas (5x/sem -1h/dia. Foram utilizados protocolos de microesferas coloridas para avaliar fluxo sanguíneo, técnicas de morfologia para avaliar hipertrofia cardíaca e análises bioquímicas para verificar atividade de enzimas envolvidas na formação de adenosina. RESULTADOS: TF por natação atenuou a evolução da HA em SHR babies (S: 145 ± 2; T: 140 ± 2mmHg, promoveu bradicardia de repouso em SHR adultos (S: 340 ± 4; T: 321 ± 6bpm e desenvolveu HC nos dois grupos (TB: 12%; TA: 10%. Na condição basal, o TF aumentou o FS coronário em SHR babies (S: 4.745 ± 2.145; T: 6.970 ± 2.374mi/coração e maior resposta vasodilatadora à infusão de adenosina foi observada (S: 18.946 ± 6.685; T: 25.045 ± 7.031mi/coração. Neste grupo, o TF promoveu maior atividade da enzima 5'-nucleotidase, levando à maior formação de adenosina (S: 0,45 ± 0,09; T: 1,01 ± 0,05. CONCLUSÃO: O TF de natação, além de desenvolver HC e apresentar maior hidrólise de AMP, promoveu aumento no FS coronário, sendo mostrado que desempenha um importante papel na regulação da hipertensão

Computer program for obtaining thermodynamic and transport properties of air and products of combustion of ASTM-A-1 fuel and air

Science.gov (United States)

Hippensteele, S. A.; Colladay, R. S.

1978-01-01

A computer program for determining desired thermodynamic and transport property values by means of a three-dimensional (pressure, fuel-air ratio, and either enthalpy or temperature) interpolation routine was developed. The program calculates temperature (or enthalpy), molecular weight, viscosity, specific heat at constant pressure, thermal conductivity, isentropic exponent (equal to the specific heat ratio at conditions where gases do not react), Prandtl number, and entropy for air and a combustion gas mixture of ASTM-A-1 fuel and air over fuel-air ratios from zero to stoichiometric, pressures from 1 to 40 atm, and temperatures from 250 to 2800 K.

150. ¿Tres en uno? Implante de tres dispositivos de asistencia circulatoria a un mismo paciente como terapia pre y postrasplante cardíaco. A propósito de un caso

Directory of Open Access Journals (Sweden)

J.A. Fernández-Divar

2012-04-01

Conclusiones: El implante ECMO es rápido y seguro, y permite mantener con vida a pacientes en shock cardiogénico grave. La reconversión a asistencias de media duración nos ayuda a mejorar el estado del paciente y que éste llegue al trasplante cardíaco en mejores condiciones. La incorporación de asistencias en pacientes con fallo primario del injerto (FPI tras el trasplante supone un avance en el tratamiento de esta patología.

Theory of monochromators based on holographic toroidal arrays for the X-UV spectrum band. Tests of the 'TGM 10 metres, 4 degrees' on the ACO storage ring

International Nuclear Information System (INIS)

Lizon a Lugrin, Eric

1988-01-01

As the use of synchrotron radiation is strongly increasing, needs for monochromators in the X-UV range are very important. This research thesis aimed at the development of prototype monochromator based toroidal lamellar arrays with grazing incidence. In the first part, the author recalls theoretical aspects of light scattering rules adapted to a lamellar array, and of wave-matter interaction rules. In the second part, he reports the calculation of the monochromator, its mechanical description, and its implementation on the light line of the ACO storage ring. In the third part, the author reports tests performed without any input slot and in reverse optical configuration on the ACO storage ring. The energy range, the linearity with respect to wave length, the rejection of higher orders of scattered light, flow and resolution are in compliance with expected values [fr

Formation of microcracks during stress-relief annealing of a weldment in pressure vessel steel of type A508 C1 2

International Nuclear Information System (INIS)

Liljestrand, L.-G.; Oestberg, G.; Lindhagen, P.

1978-01-01

Crack formation in the heat-affected zones of heavy section weldments of type A 508 C1 2 pressure vessel steel during stress-relief annealing has been studied on an actual weldment and on simulated structures. Mechanical testing of the latter showed that stress relaxation of the order of magnitude occuring during stress-relief annealing can produce cracks of the same kind as occasionally found in weldments of pressure vessel steel. The primary cause is believed to be grain boundary sliding, possibly but not necessarily enhanced by impurities. (Auth.)

Moessbauer spectroscopy study on the corrosion resistance of plasma nitrided ASTM F138 stainless steel in chloride solution

International Nuclear Information System (INIS)

Souza, S.D. de; Olzon-Dionysio, M.; Basso, R.L.O.; Souza, S. de

2010-01-01

Plasma nitriding of ASTM F138 stainless steel samples has been carried out using dc glow discharge under 80% H 2 -20% N 2 gas mixture, at 673 K, and 2, 4, and 7 h time intervals, in order to investigate the influence of treatment time on the microstructure and the corrosion resistance properties. The samples were characterized by scanning electron microscopy, glancing angle X-ray diffraction and conversion electron Moessbauer spectroscopy, besides electrochemical tests in NaCl aerated solution. A modified layer of about 6 μm was observed for all the nitrided samples, independent of nitriding time. The X-ray diffraction analysis shows broad γ N phase peaks, signifying a great degree of nitrogen supersaturation. Besides γ N, the Moessbauer spectroscopy results indicated the occurrence of γ' and ε phases, as well as some other less important phases. Corrosion measurements demonstrate that the plasma nitriding time affects the corrosion resistance and the best performance is reached at 4 h treatment. It seems that the ε/γ' fraction ratio plays an important role on the resistance corrosion. Additionally, the Moessbauer spectroscopy was decisive in this study, since it was able to identify and quantify the iron phases that influence the corrosion resistance of plasma nitrided ASTM F138 samples.

Effects of heat treatment to the sound velocity and microstructural changes of ASTM A516 steels

International Nuclear Information System (INIS)

Norasiah Abdul Kasim; Azali Muhammad; Amry Amin Abas; Zaiton Selamat

2010-01-01

Full-text: The used of ultrasonic testing as a thickness measurement for structural components (pipeline and pressure vessel) is among the popular inspection tool widely use in the industrial power plant such as at petrochemical and nuclear power plant. Currently, there are cases where the thickness grows and the result will affect the reliability of the test. There are many factors that can affect the reliability of measurement. One of it is the material under test itself. In the Malaysian Nuclear Agency, initial efforts are underway to study the understanding on the effects of heat treatment to the sound velocity and microstructure changes of ASTM A516 steel. Few samples of thin square shaped prepared were heat treated under the following conditions: austenitization at 9800 degree Celsius - 2 hours, quenching; tempering at various temperature 4000, 5000, 6000 and 7000 degree Celsius. The results show that the microstructure changes and samples exhibit different sound velocity at different heat treatment. (author)

Oxidación a alta temperatura de un acero ASTM A335 P92 en contacto con una mezcla de sales de

OpenAIRE

Jessica Rodríguez Pérez; Eduardo Santos Sánchez; Darío Yesid Peña Ballesteros; Anderson Sandoval Amador; Hugo Armando Estupiñán Durán

2016-01-01

En esta investigación se evaluó la oxidación del acero ASTM A335 P92 en una mezcla de sales 40% K2SO4 - 60% NaCl a temperaturas de 500ºC a 700ºC, a intervalos de 50°C con tiempos de exposición de 1, 3, 10, 30, 100 y 150 horas, utilizando la norma estandarizada por la Federación Europea de Corrosión. Se realizó análisis metalográfico y de dureza antes y después del ensayo para identificar el posible cambio estructural; se realizan pruebas de difracción de rayos X (DRX), microscopía electrónica...

Comparative study between EDXRF and ASTM E572 methods using two-way ANOVA

Science.gov (United States)

Krummenauer, A.; Veit, H. M.; Zoppas-Ferreira, J.

2018-03-01

Comparison with reference method is one of the necessary requirements for the validation of non-standard methods. This comparison was made using the experiment planning technique with two-way ANOVA. In ANOVA, the results obtained using the EDXRF method, to be validated, were compared with the results obtained using the ASTM E572-13 standard test method. Fisher's tests (F-test) were used to comparative study between of the elements: molybdenum, niobium, copper, nickel, manganese, chromium and vanadium. All F-tests of the elements indicate that the null hypothesis (Ho) has not been rejected. As a result, there is no significant difference between the methods compared. Therefore, according to this study, it is concluded that the EDXRF method was approved in this method comparison requirement.

Characterizing the transition region of an A508 cl3 steel using small specimens by the reference temperature and the weak-link distances

International Nuclear Information System (INIS)

Miranda, C.A.J.

2001-01-01

An experimental program was developed to characterize the transition region of an A508 cl3 steel. Some fracture mechanic specimens were tested in the transition region using three geometries with thickness B c values, the reference temperature values, To, associated with each geometry and test temperature, and the measured r wl distances and the theoretical ones. (author)

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines

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Sampson Heidi M

2013-01-01

Full Text Available Abstract Background Many genetic diseases are due to defects in protein trafficking where the mutant protein is recognized by the quality control systems, retained in the endoplasmic reticulum (ER, and degraded by the proteasome. In many cases, the mutant protein retains function if it can be trafficked to its proper cellular location. We have identified structurally diverse correctors that restore the trafficking and function of the most common mutation causing cystic fibrosis, F508del-CFTR. Most of these correctors do not act directly as ligands of CFTR, but indirectly on other pathways to promote folding and correction. We hypothesize that these proteostasis regulators may also correct other protein trafficking diseases. Methods To test our hypothesis, we used stable cell lines or transient transfection to express 2 well-studied trafficking disease mutations in each of 3 different proteins: the arginine-vasopressin receptor 2 (AVPR2, also known as V2R, the human ether-a-go-go-related gene (KCNH2, also known as hERG, and finally the sulfonylurea receptor 1 (ABCC8, also known as SUR1. We treated cells expressing these mutant proteins with 9 structurally diverse F508del-CFTR correctors that function through different cellular mechanisms and assessed whether correction occurred via immunoblotting and functional assays. Results were deemed significantly different from controls by a one-way ANOVA (p  Results Here we show that F508del-CFTR correctors RDR1, KM60 and KM57 also correct some mutant alleles of other protein trafficking diseases. We also show that one corrector, the cardiac glycoside ouabain, was found to alter the glycosylation of all mutant alleles tested. Conclusions Correctors of F508del-CFTR trafficking might have broader applications to other protein trafficking diseases.

Quality surveillance for steel forgings of SA508 Gr.3 used on the main NI equipment of AP1000 nuclear island

International Nuclear Information System (INIS)

Liu Lizhao

2011-01-01

Being a type of steel with ideal weldability, outstanding ability of anti-neutron irradiation embitterment and good property of fracture toughness and impact toughness, the steel of ASME SA508-3 was used widely for the nuclear island equipment of PWR Nuclear Power Plant. For the 3rd generation nuclear power plant AP1000, all large forgings and some critical components of the SG, RV and PRZ adopt this steel. Through analysis on the critical technical points during manufacturing of the SA508-3 forgings, this article try to identify the key points should be paid attention during the quality surveillance for this type of forgings, and to put forward the supervision method and focus during quality surveillance activities. (author)

Phases Evolution of an ASTM 335 steel under continuous cooling P91

International Nuclear Information System (INIS)

Carrizo, D.A; Danon, C.A; Ramos, C.P

2012-01-01

This paper studies the influence of the cooling rate on phase transformations and the resulting microstructure in continuous cooling cycles for an ASTM A335 P91 steel, under fixed austenization conditions. The CCT (Continuous Cooling Transformation) diagram of this material is reported in the literature, so the main phase fields are known. The final structure of the samples depends on the austenitic grain size and the cooling rate. The studied samples were austenized at 1050 o C for 30 minutes and then cooled at different rates between 50 o C/h and 300 o C/h. The identification and characterization of the phases was carried out by using Scanning Electron Microscopy, X-ray Diffraction and Moessbauer Spectroscopy. From the results so obtained, additions to the CCT diagram of the material are proposed, providing new information to it

Study on the welding continuous cooling transformation and weldability of SA508Gr4 steel for nuclear pressure vessels

International Nuclear Information System (INIS)

Bai, Qingwei; Ma, Yonglin; Xing, Shuqing; Chen, Zhongyi

2017-01-01

SA508Gr4 is a newly developed high-strength steel for nuclear reactor pressure vessels. Its welding characteristics remain largely unexplored. In this work, the simulated heat affected zone continuous cooling transformation (SH-CCT) diagram of SA508Gr4 steel was constructed and the high-temperature cooling phase compositions and the properties of the heat affected zone (HAZ) were characterized using dilatometry and microscopic tests. The results show that the phase transformation in the HAZ was divided into bainite and martensite transformation stages. When 4.6 ≤ t_8_/_5 (the HAZ cooling time from 800 C to 500 C) ≤ 15 s, lath-shaped martensite was fully developed, resulting in extensive hardening and cold cracking in the HAZ, while the cooling time required to form the bainite completely exceeds 1 200 s. Thus, to improve weld quality, preheating to 196 C or higher is recommended.

Study on the welding continuous cooling transformation and weldability of SA508Gr4 steel for nuclear pressure vessels

Energy Technology Data Exchange (ETDEWEB)

Bai, Qingwei; Ma, Yonglin; Xing, Shuqing; Chen, Zhongyi [Inner Mongolia Univ. of Science and Technology, Baotou (China). School of Material and Metallurgy; Kang, Xiaolan [Baotou Vocational and Technical College (China)

2017-02-15

SA508Gr4 is a newly developed high-strength steel for nuclear reactor pressure vessels. Its welding characteristics remain largely unexplored. In this work, the simulated heat affected zone continuous cooling transformation (SH-CCT) diagram of SA508Gr4 steel was constructed and the high-temperature cooling phase compositions and the properties of the heat affected zone (HAZ) were characterized using dilatometry and microscopic tests. The results show that the phase transformation in the HAZ was divided into bainite and martensite transformation stages. When 4.6 ≤ t{sub 8/5} (the HAZ cooling time from 800 C to 500 C) ≤ 15 s, lath-shaped martensite was fully developed, resulting in extensive hardening and cold cracking in the HAZ, while the cooling time required to form the bainite completely exceeds 1 200 s. Thus, to improve weld quality, preheating to 196 C or higher is recommended.

Standard specification for cobalt-chromium-nickel-molybdenum-tungsten alloy (UNS R31233) plate, sheet and strip. ASTM standard

International Nuclear Information System (INIS)

1998-09-01

This specification is under the jurisdiction of ASTM Committee B-2 on Nonferrous Metals and Alloys and is the direct responsibility of Subcommittee B02.07 on Refined Nickel and Cobalt, and Alloys Containing Nickel or Cobalt or Both as Principal Constituents. Current edition approved Apr. 10, 1998 and published September 1998. Originally published as B 818-91. Last previous edition was B 818-93

White Paper Summary of 2nd ASTM International Workshop on Hydrides in Zirconium Alloy Cladding

Energy Technology Data Exchange (ETDEWEB)

Sindelar, R. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Louthan, M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); PNNL, B. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2015-05-29

This white paper recommends that ASTM International develop standards to address the potential impact of hydrides on the long term performance of irradiated zirconium alloys. The need for such standards was apparent during the 2nd ASTM International Workshop on Hydrides in Zirconium Alloy Cladding and Assembly Components, sponsored by ASTM International Committee C26.13 and held on June 10-12, 2014, in Jackson, Wyoming. The potentially adverse impacts of hydrogen and hydrides on the long term performance of irradiated zirconium-alloy cladding on used fuel were shown to depend on multiple factors such as alloy chemistry and processing, irradiation and post irradiation history, residual and applied stresses and stress states, and the service environment. These factors determine the hydrogen content and hydride morphology in the alloy, which, in turn, influence the response of the alloy to the thermo-mechanical conditions imposed (and anticipated) during storage, transport and disposal of used nuclear fuel. Workshop presentations and discussions showed that although hydrogen/hydride induced degradation of zirconium alloys may be of concern, the potential for occurrence and the extent of anticipated degradation vary throughout the nuclear industry because of the variations in hydrogen content, hydride morphology, alloy chemistry and irradiation conditions. The tools and techniques used to characterize hydrides and hydride morphologies and their impacts on material performance also vary. Such variations make site-to-site comparisons of test results and observations difficult. There is no consensus that a single material or system characteristic (e.g., reactor type, burnup, hydrogen content, end-of life stress, alloy type, drying temperature, etc.) is an effective predictor of material response during long term storage or of performance after long term storage. Multi-variable correlations made for one alloy may not represent the behavior of another alloy exposed to

Hacia una descripción del cuento policíaco español contemporáneo

Directory of Open Access Journals (Sweden)

Alicia Valverde Velasco

2014-06-01

Full Text Available Desde su recepción en España, ya en el siglo XIX, el cuento policíaco nunca había experimentado un auge en su cultivo y aceptación como el acaecido a partir de los años setenta. Desde entonces, el cuento literario, como forma narrativa susceptible de desarrollar tramas de muy distinta índole, entre ellas la del hecho criminal, ha experimentado un período de reconocimiento paulatino por parte de los autores, las editoriales, el público y la crítica, por lo que no es de extrañar que los escritores del llamado “género criminal” se atreviesen a explorar las posibilidades del relato breve con mayor fortuna que durante las décadas precedentes.

An investigation of force components in orthogonal cutting of medical grade cobalt-chromium alloy (ASTM F1537).

Science.gov (United States)

Baron, Szymon; Ahearne, Eamonn

2017-04-01

An ageing population, increased physical activity and obesity are identified as lifestyle changes that are contributing to the ongoing growth in the use of in-vivo prosthetics for total hip and knee arthroplasty. Cobalt-chromium-molybdenum (Co-Cr-Mo) alloys, due to their mechanical properties and excellent biocompatibility, qualify as a class of materials that meet the stringent functional requirements of these devices. To cost effectively assure the required dimensional and geometric tolerances, manufacturers rely on high-precision machining. However, a comprehensive literature review has shown that there has been limited research into the fundamental mechanisms in mechanical cutting of these alloys. This article reports on the determination of the basic cutting-force coefficients in orthogonal cutting of medical grade Co-Cr-Mo alloy ASTM F1537 over an extended range of cutting speeds ([Formula: see text]) and levels of undeformed chip thickness ([Formula: see text]). A detailed characterisation of the segmented chip morphology over this range is also reported, allowing for an estimation of the shear plane angle and, overall, providing a basis for macro-mechanic modelling of more complex cutting processes. The results are compared with a baseline medical grade titanium alloy, Ti-6Al-4V ASTM F136, and it is shown that the tangential and thrust-force components generated were, respectively, ≈35% and ≈84% higher, depending primarily on undeformed chip thickness but with some influence of the cutting speed.

Microstructure evolution of ASTM 335 P91 steel, subjected to continuous cooling

International Nuclear Information System (INIS)

Carrizo, D.A; Danon, C.A; Ramos, C.P

2012-01-01

This paper studies the influence of the cooling rate on an isothermal phase transformations in ASTM A335 P91 steel, by the analysis of the resulting microstructure after several continuous cooling cycles under fixed austenization conditions. The CCT (Continuous Cooling Transformation) diagram of this material has already been reported in the literature, so the main phase fields are known, and they depend on the austenitic grain size and the cooling rate. Five samples were tested in a dilatometer, they were austenized and then cooled at different rates between 50 o C/h and 300 o C/h. The identification and characterization of the resulting phases was carried out by using Scanning Electron Microscopy, X-ray Diffraction and Mossbauer Spectroscopy. The obtained results allowed to add information about the presence of retained austenite and (Fe,Cr) 3 C - type carbides to the CCT diagram of the material (author)

Damage characterization of an ASTM A 213 grade 91 tube after 116.000 h of service in a reforming plant

International Nuclear Information System (INIS)

Tonti, Andrea; Lega, Daniela; Antonini, Alessandra; Romitelli, Manuela; Alvino, Antonello

2015-01-01

ASTM A213 T91 steel is used in power plants and petrochemical industry, for long-term service components. The improved mechanical properties of grade 91 are strictly related to its specific microstructure: a tempered martensite matrix with fine precipitates embedded in. Despite low alloy heat resistant ferritic steels, that have a well known operational experience, T91 service performances are still faintly consolidated, because this material has serviced only in a limited number of plants, since the eighties. Most of the available data were obtained by laboratory tests on relatively short term creep strength and corrosion properties. The investigations reported in this paper represent an important opportunity to describe and better evaluate the damage evolution of the grade T91 steel after more than 100000 h of exposure in severe conditions (580 °C, 18–26 bar, combustion environment). Our results suggest that the steel suffered by different damage forms, which appear on definite portions of the tube cross section. The main degradation forms observed, in fact, into the tube bulk are both the martensite recovery and the microstructural evolution. This latter promoted mostly Laves phase precipitation and coarsening. On the other hand, both the outer and the inner wall side, suffered mainly by severe oxidation/carburization. Especially on the outer surface, the massive carbide precipitation has caused an evident loss of ductility so that the mechanical properties of the tube appear appreciably reduced. - Highlights: • ASTM A213 T91 steel is used in petrochemical industry, for long-term service components. • The investigations reported an evaluation of the damage evolution of the grade T91 steel. • Our results suggest that the steel suffered both the martensite recovery and the microstructural evolution. • The outer and the inner wall side, suffered mainly by severe oxidation/carburization. • Carbide precipitation caused loss of ductility so that the

Ant Colony Optimization ACO For The Traveling Salesman Problem TSP Using Partitioning

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Alok Bajpai

2015-08-01

Full Text Available Abstract An ant colony optimization is a technique which was introduced in 1990s and which can be applied to a variety of discrete combinatorial optimization problem and to continuous optimization. The ACO algorithm is simulated with the foraging behavior of the real ants to find the incremental solution constructions and to realize a pheromone laying-and-following mechanism. This pheromone is the indirect communication among the ants. In this paper we introduces the partitioning technique based on the divide and conquer strategy for the traveling salesman problem which is one of the most important combinatorial problem in which the original problem is partitioned into the group of sub problems. And then we apply the ant colony algorithm using candidate list strategy for each smaller sub problems. After that by applying the local optimization and combining the sub problems to find the good solution for the original problem by improving the exploration efficiency of the ants. At the end of this paper we have also be presented the comparison of result with the normal ant colony system for finding the optimal solution to the traveling salesman problem.

The effect of water injection on nitric oxide emissions of a gas turbine combustor burning ASTM Jet-A fuel

Science.gov (United States)

Marchionna, N. R.; Diehl, L. A.; Trout, A. M.

1973-01-01

Tests were conducted to determine the effect of water injection on oxides of nitrogen (NOx) emissions of a full annular, ram induction gas turbine combustor burning ASTM Jet-A fuel. The combustor was operated at conditions simulating sea-level takeoff and cruise conditions. Water at ambient temperature was injected into the combustor primary zone at water-fuel ratios up to 2. At an inlet-air temperature of 589 K (600 F) water injection decreased the NOx emission index at a constant exponential rate: NOx = NOx (o) e to the -15 W/F power (where W/F is the water-fuel ratio and NOx(o) indicates the value with no injection). The effect of increasing combustor inlet-air temperature was to decrease the effect of the water injection. Other operating variables such as pressure and reference Mach number did not appear to significantly affect the percent reduction in NOx. Smoke emissions were found to decrease with increasing water injection.

123. Intervención quirúrgica urgente en paciente varón joven con angiosarcoma primario cardíaco con diagnóstico de tromboembolismo pulmonar agudo

Directory of Open Access Journals (Sweden)

N. Miranda

2012-04-01

Conclusiones: Son infrecuentes los casos de sarcoma cardíaco primario publicados en la bibliografía y muy pocos los que han cursado como tromboembolismo pulmonar agudo. Este caso ilustra la enorme dificultad que presentan para un diagnóstico y tratamiento precoz que ofrezca unas mínimas expectativas de vida a medio plazo.

Impacto del riesgo cardíaco sobre la Aneurismectomía

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Orestes Díaz Hernández

2000-04-01

Full Text Available Se realiza un análisis cardiológico a 100 pacientes a los cuales se les efectuó cirugía electiva por aneurisma de la aorta abdominal infrarrenal; para esto se emplearon 5 métodos: el índice de riesgo cardíaco de Goldman original y modificado, los marcadores coronarios de Eagle, las indicaciones por niveles recomendadas por Hollier y la ecuación de Cooperman. La cardiopatía isquémica se detectó en el 59 % del total de los pacientes. De ellos, el 43 % tenía antecedentes de infarto del miocardio, el 33 % angina estable bajo tratamiento medicamentoso, el 6 % insuficiencia cardíaca congestiva con tratamiento digitálico y el 11 % un ritmo no sinusal detectado en el electrocardiograma. La supervivencia a largo plazo en la cardiopatía isquémica se comportó al año y 2 años en el 80 %, a los 5 años en el 72 % y a los 10 y 13 años en el 35 %. Se propone un algoritmo simple y modificado de valoración cardiológica en los pacientes que muestran aneurisma de la aorta abdominalA cardiological analysis of 100 patients whe underwent elective surgery due to infrarenal abdominal aortic aneurysm was made. 5 methods were used to this end: the original and modified Goldman´s cardiac resk index, Eagle´s coronary markers, the indications by levels recommended by Hollier and Cooperman´s equation. Ischaemic heart disease was detected in 59 % of the patients. 43 % of them had history of myocardial infarction, 33 % of stable angina under drug treatment, 6 % of congestive heart failure with digitalis treatment and 11 % had a nonsinusal rate detected in the EKG. Among those suffering from schemic heart disease there was a long term survival of 80 % at the lst and 2nd year, 72 % at the 5 th year, and 35 % at the 10th and 13th year. A simple and modified algorithm of cardiological assessment was proposed for patients with abdominal aortic aneurysm

Investigation of fatigue crack growth in SA508-2 in a 2880C PWR environment by a constant δK test method

International Nuclear Information System (INIS)

Van Der Sluys, W.A.; DeMiglio, D.S.

1983-01-01

Fatigue crack growth experiments using a constant δK test technique were conducted on three 50.8 mm thick compact fracture specimens of SA508-2 in a 288 0 C simulated PWR water environment. Alternating stress intensity factor (δK) values were investigated in the range 16.5 to 44 MPa√m at sinusoidal loading frequencies ranging from 10 to .017 Hz (1 cpm) and R ratios 0.03 to 0.72. For a given δK and frequency, δK was held constant to within 1%. A steady-state rate of crack growth per cycle of stress (da/dN) was determined for each test condition. Over a typical crack extension of 1.3 mm, the crack growth rate in many cases was a constant. As many as 14 separate experiments were conducted on a single specimen. There was no influence of prior loading history or crack length on the crack growth rate. It was found that the crack growth rate was controlled by the δK, frequency, and R ratio of the test. Large changes in the crack growth rate did not occur as the frequency of loading was decreased from >1 Hz to .017 Hz (1 cpm). As compared to high frequency results (>1 Hz) the crack growth rate increased slightly at 1 cpm for δK > 22 MPa√m and decreased slightly for δK < 22 MPa√m. At 1 cpm the R ratio was observed to influence the crack growth rate; however, the magnitude of this effect was not well-defined

Model of ASTM Flammability Test in Microgravity: Iron Rods

Science.gov (United States)

Steinberg, Theodore A; Stoltzfus, Joel M.; Fries, Joseph (Technical Monitor)

2000-01-01

There is extensive qualitative results from burning metallic materials in a NASA/ASTM flammability test system in normal gravity. However, this data was shown to be inconclusive for applications involving oxygen-enriched atmospheres under microgravity conditions by conducting tests using the 2.2-second Lewis Research Center (LeRC) Drop Tower. Data from neither type of test has been reduced to fundamental kinetic and dynamic systems parameters. This paper reports the initial model analysis for burning iron rods under microgravity conditions using data obtained at the LERC tower and modeling the burning system after ignition. Under the conditions of the test the burning mass regresses up the rod to be detached upon deceleration at the end of the drop. The model describes the burning system as a semi-batch, well-mixed reactor with product accumulation only. This model is consistent with the 2.0-second duration of the test. Transient temperature and pressure measurements are made on the chamber volume. The rod solid-liquid interface melting rate is obtained from film records. The model consists of a set of 17 non-linear, first-order differential equations which are solved using MATLAB. This analysis confirms that a first-order rate, in oxygen concentration, is consistent for the iron-oxygen kinetic reaction. An apparent activation energy of 246.8 kJ/mol is consistent for this model.

Overview (this manuscript is an overview of an ASTM symposium. The authors, John Sebroski and Mark Mason, of the overview were the co-chairs of the symposium and co-editors of the manuscripts submitted for ASTM peer review and subsequent publication in the technical proceedings for the symposium)

Science.gov (United States)

The Symposium on Developing Consensus Standards for Measuring Chemical Emissions from Spray Polyurethane Foam (SPF) Insulation was held on April 30th and May 1, 2015. Sponsored by ASTM Committee D22 on Air Quality, the symposium was held in Anaheim, CA, in conjunction with the st...

Effects of strength mis-matching on the fracture behavior of nuclear pressure steel A508-III welded joint

Energy Technology Data Exchange (ETDEWEB)

Zhu Zhengqiang [School of Material Science and Technology, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030 (China)]. E-mail: zhuzhq01@sjtu.edu.cn; Jing Hongyang [School of Material Science and Technology, Tianjin University, Tianjin 300072 (China); Ge Jingguo [School of Material Science and Technology, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030 (China); Chen Ligong [School of Material Science and Technology, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030 (China)

2005-01-15

In this paper, according to the nuclear pressure steel A508-III, the effect of strength mis-matching on the fracture behavior was analyzed by fracture mechanics test and the crack tip stress field of three-point bend specimen was analyzed by using finite element analysis method (FEM). The fracture of heat-affected zone (HAZ) was emphasized especially. The results of FEM show that if the under-matching weld was used, the opening stress and stress triaxiality in the vicinity of crack tip would increase for weld-crack specimen, and would reduce for HAZ-crack specimen. This tendency was confirmed by the test results.

Aerodynamic effect of a honeycomb rotor tip shroud on a 50.8-centimeter-tip-diameter core turbine

Science.gov (United States)

Moffitt, T. P.; Whitney, W. J.

1983-01-01

A 50.8-cm-tip-diameter turbine equipped with a rotor tip shroud of hexagonal cell (or honeycomb) cross section has been tested in warm air (416 K) for a range of shroud coolant to primary flow rates. Test results were also obtained for the same turbine operated with a solid shroud for comparison. The results showed that the combined effect of the honeycomb shroud and the coolant flow was to cause a reduction of 2.8 points in efficiency at design speed, pressure ratio, and coolant flow rate. With the coolant system inactivated, the honeycomb shroud caused a decrease in efficiency of 2.3 points. These results and those obtained from a small reference turbine indicate that the dominant factor governing honeycomb tip shroud loss is the ratio of honeycomb depth to blade span. The loss results of the two shrouds could be correlated on this basis. The same honeycomb and coolant effects are expected to occur for the hot (2200 K) version of this turbine.

Hardness optimization of boride diffusion layer on Astm F-75 alloy using response surface methodology

Energy Technology Data Exchange (ETDEWEB)

Arguelles O, J. L.; Corona R, M. A. [Universidad Autonoma de San Luis Potosi, Doctorado Institucional en Ingenieria y Ciencia de Materiales, San Luis Potosi 78000, SLP (Mexico); Marquez H, A.; Saldana R, A. L.; Saldana R, A. [Universidad de Guanajuato, Ingenieria Mecanica Agricola DICIVA, Irapuato, Guanajuato 36500 (Mexico); Moreno P, J., E-mail: amarquez@ugto.mx [Universidad de Guanajuato, Departamento de Minas, Metalurgia y Geologia, Ex-Hacienda San Matias s/n, Guanajuato, Guanajuato 36020 (Mexico)

2017-11-01

In this study, the Response Surface Methodology (Rsm) and Central Composite Design (Ccd) were used to optimize the hardness of boride diffusion layer on Astm F-75 alloy (also called Haynes alloy). A boronizing thermochemical treatment was carried out at different temperatures and for different time periods. Hardness tests were conducted. The boride diffusion layer was verified by the X-ray diffraction (XRD) analysis indicating the formation of Co B, Co{sub 2}B, Cr B and Mo{sub 2}B phases. An optimal hardness of 3139.7 Hv was obtained for the samples subjected to the boriding process for a duration of 6.86 h at 802.4 degrees Celsius. (Author)

Measurement of susceptibility artifacts with histogram-based reference value on magnetic resonance images according to standard ASTM F2119.

Science.gov (United States)

Heinrich, Andreas; Teichgräber, Ulf K; Güttler, Felix V

2015-12-01

The standard ASTM F2119 describes a test method for measuring the size of a susceptibility artifact based on the example of a passive implant. A pixel in an image is considered to be a part of an image artifact if the intensity is changed by at least 30% in the presence of a test object, compared to a reference image in which the test object is absent (reference value). The aim of this paper is to simplify and accelerate the test method using a histogram-based reference value. Four test objects were scanned parallel and perpendicular to the main magnetic field, and the largest susceptibility artifacts were measured using two methods of reference value determination (reference image-based and histogram-based reference value). The results between both methods were compared using the Mann-Whitney U-test. The difference between both reference values was 42.35 ± 23.66. The difference of artifact size was 0.64 ± 0.69 mm. The artifact sizes of both methods did not show significant differences; the p-value of the Mann-Whitney U-test was between 0.710 and 0.521. A standard-conform method for a rapid, objective, and reproducible evaluation of susceptibility artifacts could be implemented. The result of the histogram-based method does not significantly differ from the ASTM-conform method.

Tamponamento cardíaco tardio traumático: análise de cinco casos Traumatic late cardiac tamponade: analysis of five cases

Directory of Open Access Journals (Sweden)

FERNANDO LUIZ WESTPHAL

2000-09-01

Full Text Available São analisados cinco casos de tamponamento cardíaco tardio traumático. Os pacientes eram masculinos, idade média de 26,2 anos, vítimas de ferimento por arma branca em região precordial, área de Ziedler, sendo admitidos em centro de referência para trauma. Foram classificados pelo índice fisiológico de Ivatury para trauma cardíaco e inicialmente tratados por pleurotomia intercostal e reposição volêmica, com estabilização do quadro hemodinâmico e respiratório. Os pacientes foram readmitidos após intervalo de oito a 24 dias (mediana de 20 dias, agora no serviço de cirurgia torácica de um hospital de referência terciária, com sinais de tamponamento cardíaco. Os exames diagnósticos confirmaram derrame pericárdico com espessamento pericárdico associado a encarceramento de base pulmonar esquerdo em quatro casos, os quais foram abordados por toracotomia póstero-lateral, com realização de pericardiectomia parcial e descorticação pulmonar. Um paciente evoluiu com pericardite purulenta, comprovada por exames complementares, e foi submetido à drenagem pericárdica subxifóidea. Ocorreu arritmia pós-operatória em um paciente; os demais evoluíram sem complicações pós-operatórias ou recidiva do tamponamento.Five traumatic late cardiac tamponade cases were analyzed. All patients were male, mean age was 26.2, victims of thoracic penetrating stabbing wound in the precordial region, Ziedler area, admitted to a trauma reference center. They were classified by the Ivatury physiological index for cardiac trauma. The first treatment approach was intercostal pleurectomy and volemic resuscitation followed by hemodynamic and respiratory recovery. Patients with cardiac tamponade symptoms were re-admitted within an interval from eight to twenty four days (mean 20 days in a thoracic surgery service of a tertiary reference hospital. Diagnostic exams confirmed thickening and pericardial effusion associated with a left pulmonary base

Experiência com transplante cardíaco heterotópico em pacientes com resistência pulmonar elevada: seguimento tardio Experiencia con trasplante cardíaco heterotópico en pacientes con resistencia pulmonar elevada: seguimiento tardío Experience with heterotopic heart transplantation in patients with elevated pulmonary vascular resistance: late follow-up

Directory of Open Access Journals (Sweden)

Jose Henrique Andrade Vila

2010-02-01

Full Text Available FUNDAMENTO: Nos últimos anos o numero de artigos sobre transplante cardíaco heterotópico tem sido escasso na literatura, inclusive internacional, e em particular do seguimento de longo prazo destes pacientes, o que levou ao presente relato. OBJETIVO: Relatar a experiência clínica inicial e evolução tardia de quatro pacientes submetidos a transplante cardíaco heterotópico, sua indicação e principais complicações. MÉTODOS: As cirurgias ocorreram entre 1992 e 2001, sendo que a indicação de transplante heterotópico, em todas, foi pela RVP, variável de 4,8UW a 6.5UW, com gradiente transpulmonar acima de 15mmHg. No 3º paciente, foi realizada uma anastomose direta entre as artérias pulmonares sem emprego de tubo protético e, no coração nativo, foi realizada uma valvoplastia mitral e aneurismectomia de ventrículo esquerdo (VE. O esquema imunossupressor imediato foi duplo com ciclosporina e azatioprina nos três primeiros pacientes e ciclosporina e micofenolato mofetil no 4º paciente. RESULTADOS: Um óbito imediato por falência do enxerto, um óbito após dois anos e meio por endocardite em trombo intraventricular no coração nativo, e um terceiro óbito seis anos após o transplante, por complicações pós-operatórias de cirurgia na valva aórtica do coração nativo. O remanescente, 15 anos após o transplante, encontra-se bem, em classe funcional II (NYHA, seis anos após a oclusão cirúrgica da valva aórtica do coração nativo. CONCLUSÃO: O transplante cardíaco heterotópico é um procedimento com resultado inferior ao transplante cardíaco ortotópico, por apresentarem maior RVP. Os trombos intraventriculares no coração nativo, que exigem anticoagulação prolongada, bem como as complicações de válvula aórtica, também no coração nativo, podem exigir tratamento cirúrgico. Entretanto, em um paciente, a sobrevida de 15 anos mostrou a eficácia de longo prazo desse tipo de alternativa, para pacientes

Determination of CTOD C in Fibre Metal Laminates by ASTM and Schwalbe Methods

Directory of Open Access Journals (Sweden)

E.M. Castrodeza

2002-06-01

Full Text Available Fibre Metal Laminates (FMLs have arisen as a demand of the aeronautical industry to use thin sheets with high resistance to fatigue crack growth, high damage tolerance, corrosion resistance and high specific strength. Considering these requirements, FMLs are an advantageous choice when compared to metal alloys currently used. In order to employ FMLs in aircraft structures, designers must hold a deep knowledge of a wide set of their properties including fracture toughness. The aim of this work was to evaluate the available methodologies to measure fracture toughness at instability (CTOD C in unidirectional fibre metal laminates reinforced with aramid fibres (ARALL®. To achieve this, tests were performed to obtain traditional and Schwalbe CTODs by using experimental ASTM based techniques, especially adapted to these laminates. Results achieved point out that Schwalbe method is more appropriate and also that there are differences between both CTOD parameters.

MGA trajectory planning with an ACO-inspired algorithm

Science.gov (United States)

Ceriotti, Matteo; Vasile, Massimiliano

2010-11-01

Given a set of celestial bodies, the problem of finding an optimal sequence of swing-bys, deep space manoeuvres (DSM) and transfer arcs connecting the elements of the set is combinatorial in nature. The number of possible paths grows exponentially with the number of celestial bodies. Therefore, the design of an optimal multiple gravity assist (MGA) trajectory is a NP-hard mixed combinatorial-continuous problem. Its automated solution would greatly improve the design of future space missions, allowing the assessment of a large number of alternative mission options in a short time. This work proposes to formulate the complete automated design of a multiple gravity assist trajectory as an autonomous planning and scheduling problem. The resulting scheduled plan will provide the optimal planetary sequence and a good estimation of the set of associated optimal trajectories. The trajectory model consists of a sequence of celestial bodies connected by two-dimensional transfer arcs containing one DSM. For each transfer arc, the position of the planet and the spacecraft, at the time of arrival, are matched by varying the pericentre of the preceding swing-by, or the magnitude of the launch excess velocity, for the first arc. For each departure date, this model generates a full tree of possible transfers from the departure to the destination planet. Each leaf of the tree represents a planetary encounter and a possible way to reach that planet. An algorithm inspired by ant colony optimization (ACO) is devised to explore the space of possible plans. The ants explore the tree from departure to destination adding one node at the time: every time an ant is at a node, a probability function is used to select a feasible direction. This approach to automatic trajectory planning is applied to the design of optimal transfers to Saturn and among the Galilean moons of Jupiter. Solutions are compared to those found through more traditional genetic-algorithm techniques.

Estudo anatômico dos gânglios celíaco, celiacomesentérico e mesentérico cranial e de suas conexões no gato doméstico (Felix domestica, Linnaeus, 1758

Directory of Open Access Journals (Sweden)

Antonio Augusto Coppi Maciel Ribeiro

2000-01-01

Full Text Available O gânglio celíaco é um dos principais responsáveis pela inervação do estômago, intestinos, fígado, pâncreas e ainda contribui para a inervação do baço, sendo desta forma essencial ao controle da motilidade gastrointestinal. O conhecimento do suprimento nervoso endereçado a estes órgãos é fundamental na clínica médica e cirúrgica no tocante às atonias digestivas, gastroenterites hemorrágicas, torções gástricas e invaginações intestinais. Neste trabalho, estudou-se a anatomia macro e microscópica dos gânglios celíaco, celiacomesentérico e mesentérico cranial. Foram utilizados trinta gatos domésticos, adultos, 10 machos e 20 fêmeas. A aorta torácica desses gatos foi injetada com solução de Neoprene látex 650 corada, sendo os animais congelados por no mínimo 48 horas. A fixação foi feita posteriormente com solução aquosa de formol a 10%. Nos estudos microscópicos, utilizaram-se as seguintes colorações: hematoxilina-eosina, tricrômico de Masson, reticulina e hematoxilina ácida fosfotúngstica. O gânglio celíaco ocorreu 7 vezes, sendo 4 direitos e 3 esquerdos, predominando a forma elíptica (23,3% e a situação periarterial. Os gânglios celiacomesentéricos foram contados em número de 24, sendo 11 independentes; 2 apresentando as porções direita e esquerda e 11 gânglios celiacomesentéricos direitos com uma porção mesentérica cranial esquerda, tendo formato semilunar assimétrico. Esses achados sugerem o predomínio da fusão do gânglio celíaco ao mesentérico cranial, constituindo assim o gânglio celiacomesentérico. Este é formado por neurônios imersos em abundante matriz conjuntiva fibrosa, envoltos por uma cápsula contendo fibras elásticas, colágenas e reticulares, apresentando uma continuidade nos pontos de fusão ganglionar.

Endovascular repair of an aorto-iliac aneurysm succeeded by kidney transplantation Tratamento endovascular de aneurisma aorto-ilíaco sucedido por transplante renal

Directory of Open Access Journals (Sweden)

Marcelo Bellini Dalio

2010-09-01

Full Text Available We present the case of aorto-iliac aneurysm in a patient with chronic renal failure requiring dialysis who were treated with an endovascular stent graft and, later on, submitted to kidney transplantation. A 53-year-old male with renal failure requiring dialysis presented with an asymptomatic abdominal aorto-iliac aneurysm measuring 5.0cm of diameter. He was treated with endovascular repair technique, being used an endoprosthesis Excluder®. After four months, he was successfully submitted to kidney transplantation (dead donor, with anastomosis of the graft renal artery in the external iliac artery distal to the endoprosthesis. The magnetic resonance imaging, carried out 30 days after the procedure, showed a good positioning of the endoprosthesis and adequate perfusion of the renal graft. In the follow-up, the patient presented improvement of nitrogenous waste, good positioning of the endoprosthesis without migration or endoleak. The endovascular repair of aorto-iliac aneurysm in a patient with end-stage renal failure under hemodialysis treatment showed to be feasible, safe and efficient, as it did not prevent the success of the posterior kidney transplantation.Apresentamos o caso de aneurisma aortoilíaco em um paciente com insuficiência renal crônica dialítica tratado com uma endoprótese vascular, sendo, após, submetido a transplante renal. Um homem de 53 anos com insuficiência renal dialítica apresentava um aneurisma abdominal aortoilíaco assintomático com 5,0cm de diâmetro. Foi tratado com técnica endovascular com uma endoprótese Excluderâ. Após quatro meses, foi submetido a transplante renal (doador cadáver com sucesso, com anastomose da artéria renal do enxerto na artéria ilíaca externa distal à endoprótese. A ressonância magnética 30 dias após o procedimento mostrou a endoprótese bem posicionada e o enxerto renal bem perfundido. No seguimento, o paciente evoluiu com melhora das escórias nitrogenadas, bom

Microstructure, local mechanical properties and stress corrosion cracking susceptibility of an SA508-52M-316LN safe-end dissimilar metal weld joint by GTAW

Energy Technology Data Exchange (ETDEWEB)

Ming, Hongliang; Zhu, Ruolin [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning KeyLaboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049 (China); Zhang, Zhiming [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning KeyLaboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Wang, Jianqiu, E-mail: wangjianqiu@imr.ac.cn [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning KeyLaboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Han, En.-Hou.; Ke, Wei [Key Laboratory of Nuclear Materials and Safety Assessment, Liaoning KeyLaboratory for Safety and Assessment Technique of Nuclear Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 (China); Su, Mingxing [Shanghai Research Center for Weld and Detection Engineering Technique of Nuclear Equipment, Shanghai 201306 (China)

2016-07-04

The microstructure, local mechanical properties and local stress corrosion cracking susceptibility of an SA508-52M-316LN domestic dissimilar metal welded safe-end joint used for AP1000 nuclear power plant prepared by automatic gas tungsten arc welding was studied in this work by optical microscopy, scanning electron microscopy (with electron back scattering diffraction and an energy dispersive X-ray spectroscopy system), micro-hardness testing, local mechanical tensile testing and local slow strain rate tests. The micro-hardness, local mechanical properties and stress corrosion cracking susceptibility across this dissimilar metal weld joint vary because of the complex microstructure across the fusion area and the dramatic chemical composition change across the fusion lines. Briefly, Type I boundaries and Type II boundaries exist in 52Mb near the SA508-52Mb interface, a microstructure transition was found in SA508 heat affected zone, the residual strain and grain boundary character distribution changes as a function of the distance from the fusion boundary in 316LN heat affected zone, micro-hardness distribution and local mechanical properties along the DMWJ are heterogeneous, and 52Mw-316LN interface has the highest SCC susceptibility in this DMWJ while 316LN base metal has the lowest one.

Designing cathodic protection systems for marine structures and vehicles. ASTM special technical publication 1370

Energy Technology Data Exchange (ETDEWEB)

Hack, H.P. [ed.

1999-07-01

Cathodic protection is an important method of protecting structures and ships from the corrosive effects of seawater. Poor designs can be far more costly to implement than optimal designs, Improper design can cause overprotection, with resulting paint blistering and accelerated corrosion of some alloys, underprotection, with resultant structure corrosion, or stray current corrosion of nearby structures. The first ASTM symposium specifically aimed at cathodic protection in seawater was intended to compile all the criteria and philosophy for designing both sacrificial and impressed current cathodic protection systems for structures and vehicles in seawater. The papers which are included in this STP are significant in that they summarize the major seawater cathodic protection system design philosophies. Papers have been processed separately for inclusion on the database.

Effects of oxidation-nitridation in the presence of water vapor on ASTM A335 P92 steel using SEM-EDS and XPS characterization techniques

Science.gov (United States)

Orozco, J. C.; Kafarov, V.; Y Peña, D.; Alviz, A.

2017-12-01

This research studies the physical and chemical changes in steel ASTM A335 P92, produced from a typical refinery corrosion environment. The environment evaluated was oxidation-nitridation with the presence of water vapor. In this study five (5) exposure times were selected: 1, 20, 50, 100 and 200 hours; As well as two (2) analysis temperatures: 450 and 550°C. The working pressure used was one (1) atmosphere. Bearing in mind the kinetic study, the behaviour shown in ASTM A335 P92 steel describes an accelerated growth until 50 hours, after this time growth is less. For the tests carried out at 450°C, the kinetic constant was 2x10-8g2mm-4h-1, as well as for 550°C the calculated kinetic constant was 3.1×10-7g2mm-4h-1 through the SEM-EDS characterization techniques, it was possible to appreciate a good adhesion and homogeneity of the layers formed on the metal matrix until a time of exposure of 100 hours at 450 and 550°C, different from that evidenced to 200 hours of exposure where the layer formed near to the substrate showed detachment, this is attributed to the formation of hydroxides product of water vapor. Among the results obtained are the elemental composition, the presence of nitrides such as Si3N4, also NSiO2 and NSi2O, molybdenum oxides: MoO2 and MoO3 and iron oxides: FeO and Fe2O3 can be evidenced.

Whole glove permeation of cyclohexanol through disposable nitrile gloves on a dextrous robot hand and comparison with the modified closed-loop ASTM F739 method 1. No fist clenching.

Science.gov (United States)

Mathews, Airek R; Que Hee, Shane S

2017-04-01

The aim was to develop a whole glove permeation method for cyclohexanol to generate permeation parameter data for a non-moving dextrous robot hand (normalized breakthrough time t b , standardized breakthrough time t s , steady state permeation rate P s , and diffusion coefficient D). Four types of disposable powderless, unsupported, and unlined nitrile gloves from the same producer were investigated: Safeskin Blue and Kimtech Science Blue, Purple, and Sterling. The whole glove method developed involved a peristaltic pump for water circulation through chemically resistant Viton tubing to continually wash the inner surface of the test glove via holes in the tubing, a dextrous robot hand operated by a microprocessor, a chemically protective nitrile glove to protect the robot hand, an incubator to maintain 35°C temperature, and a hot plate to maintain 35°C at the sampling point of the circulating water. Aliquots of 1.0 mL were sampled at regular time intervals for the first 60 min followed by removal of 0.5 mL aliquots every hour to 8 hr. Quantification was by the internal standard method after gas chromatography-selective ion electron impact mass spectrometry using a non-polar capillary column. The individual glove values of t b and t s differed for the ASTM closed loop method except for Safeskin Blue, but did not for the whole glove method. Most of the kinetic parameters agreed within an order of magnitude for the two techniques. The order of most protective to least protective glove was Blue and Safeskin, then Purple followed by Sterling for the whole gloves. The analogous order for the modified F739 ASTM closed loop method was: Safeskin, Blue, Purple, and Sterling, almost the same as for the whole glove. The Sterling glove was "not recommended" from the modified ASTM data, and was "poor" from the whole glove data.

Efecto de la incorporación de fibras dietéticas en la calidad de panes para celíacos

OpenAIRE

Díaz Malmierca, Álvaro

2013-01-01

La investigación en la elaboración de panes sin gluten está muy avanzada, siendo el déficit en micronutrientes de estos productos uno de los problemas sobre el que se está centrando la investigación. Uno de los nutrientes más deficitarios, y que más problemas causa sobre la salud de los pacientes celíacos es la fibra dietética. En este estudio se ha investigado el efecto que produce la adición de un 10% de diferentes fibras sobre las características de los panes, la influencia ...

Standard practice for application of thermoluminescence-dosimetry (TLD) systems for determining absorbed dose in radiation-hardness testing of electronic devices. ASTM standard

International Nuclear Information System (INIS)

1998-05-01

This practice is under the jurisdiction of ASTM Committee E-10 on Nuclear Technology and Applications and is the direct responsibility of Subcommittee E10.07 on Radiation Dosimetry for Radiation Effects on Materials and Devices. Current edition approved Jun. 10, 1997. Published May 1998. Originally published as E 668-78. Last previous edition E 668-93

Welding by submerged arc of steel with addition of iron powder; Soldagem por arco submerso de aco microligado com adicao de po de ferro

Energy Technology Data Exchange (ETDEWEB)

Gomes, Samuel I.N.; Spinelli, Dirceu [Sao Paulo Univ., Sao Carlos, SP (Brazil). Escola de Engenharia; Souza, Paulo C.R. D. de [SICOM Compressores Ltda., Sao Carlos, SP (Brazil); Magalhaes Bento Goncalves, Gilberto de [Bauru Univ., SP (Brazil)

1993-12-31

Welding metals with and without iron powder addition were produced in steel plates ASTM A 242 by submerged arc process. as a conclusion, the mechanical properties of hardness and toughness of weld metal and heat affect zone were more affected when the welding were done with lower heat input. (author). 16 refs., 3 figs., 9 tabs.

Extracción de un catéter fracturado mediante cateterismo cardíaco intervencionista en un paciente prematuro de 1 600 g

Directory of Open Access Journals (Sweden)

Francisco Javier Ozores Suárez

2011-06-01

Full Text Available Se documenta el caso de un paciente de 1 mes de edad, prematuro, con peso de 1 600 g, cuyo catéter epicutáneo se fracturó y desplazó hasta ubicarse en la porción distal en la rama izquierda de la arteria pulmonar. El catéter se extrajo por vía femoral mediante un procedimiento de cateterismo cardíaco intervencionista, con lo que se demostró la efectividad de dicho procedimiento ante este tipo de complicación.

Heat treatment temperature influence on ASTM A890 GR 6A super duplex stainless steel microstructure

International Nuclear Information System (INIS)

Martins, Marcelo; Casteletti, Luiz Carlos

2005-01-01

Duplex and super duplex stainless steels are ferrous alloys with up to 26% chromium, 8% nickel, 5% molybdenum and 0.3% nitrogen, which are largely used in applications in media containing ions from the halogen family, mainly the chloride ion (Cl - ). The emergence of this material aimed at substituting Copper-Nickel alloys (Cupro-Nickel) that despite presenting good corrosion resistance, has mechanical properties quite inferior to steel properties. The metallurgy of duplex and super duplex stainless steel is complex due to high sensitiveness to sigma phase precipitation that becomes apparent, due to the temperatures they are exposed on cooling from solidification as well as from heat treatment processes. The objective of this study was to verify the influence of heat treating temperatures on the microstructure and hardness of ASTM A890/A890M Gr 6A super duplex stainless steel type. Microstructure control is of extreme importance for castings, as the chemical composition and cooling during solidification inevitably provide conditions for precipitation of sigma phase. Higher hardness in these materials is directly associated to high sigma phase concentration in the microstructure, precipitated in the ferrite/austenite interface. While heat treatment temperature during solution treatment increases, the sigma phase content in the microstructure decreases and consequently, the material hardness diminishes. When the sigma phase was completely dissolved by the heat treatment, the material hardness was influenced only due to ferrite and austenite contents in the microstructure

Validation of standard ASTM F2732 and comparison with ISO 11079 with respect to comfort temperature ratings for cold protective clothing.

Science.gov (United States)

Gao, Chuansi; Lin, Li-Yen; Halder, Amitava; Kuklane, Kalev; Holmér, Ingvar

2015-01-01

American standard ASTM F2732 estimates the lowest environmental temperature for thermal comfort for cold weather protective clothing. International standard ISO 11079 serves the same purpose but expresses cold stress in terms of required clothing insulation for a given cold climate. The objective of this study was to validate and compare the temperature ratings using human subject tests at two levels of metabolic rates (2 and 4 MET corresponding to 116.4 and 232.8 W/m(2)). Nine young and healthy male subjects participated in the cold exposure at 3.4 and -30.6 °C. The results showed that both standards predict similar temperature ratings for an intrinsic clothing insulation of 1.89 clo and for 2 MET activity. The predicted temperature rating for 2 MET activity is consistent with test subjects' thermophysiological responses, perceived thermal sensation and thermal comfort. For 4 MET activity, however, the whole body responses were on the cold side, particularly the responses of the extremities. ASTM F2732 is also limited due to its omission and simplification of three climatic variables (air velocity, radiant temperature and relative humidity) and exposure time in the cold which are of practical importance. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Sildenafil vs. Nitroprussiato de Sódio durante Teste de Reatividade Pulmonar pré-transplante cardíaco

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Aguinaldo Figueiredo Freitas Jr

2012-09-01

Full Text Available FUNDAMENTO: A hipertensão pulmonar é associada ao pior prognóstico no pós-transplante cardíaco. O teste de reatividade pulmonar com Nitroprussiato de Sódio (NPS está associado a elevados índices de hipotensão arterial sistêmica, disfunção ventricular do enxerto transplantado e elevadas taxas de desqualificação para o transplante. OBJETIVO: Neste estudo, objetivou-se comparar os efeitos do Sildenafil (SIL e NPS sobre variáveis hemodinâmicas, neuro-hormonais e ecocardiográficas durante teste de reatividade pulmonar. MÉTODOS: Os pacientes foram submetidos, simultaneamente, ao cateterismo cardíaco direito, ao ecocardiograma e à dosagem de BNP e gasometria venosa, antes e após administração de NPS (1 - 2 µg/Kg/min ou SIL (100 mg, dose única. RESULTADOS: Ambos reduziram a hipertensão pulmonar, porém o nitrato promoveu hipotensão sistêmica significativa (Pressão Arterial Média - PAM: 85,2 vs. 69,8 mmHg, p < 0,001. Ambos reduziram as dimensões cardíacas e melhoraram a função cardíaca esquerda (NPS: 23,5 vs. 24,8 %, p = 0,02; SIL: 23,8 vs. 26 %, p < 0,001 e direita (SIL: 6,57 ± 2,08 vs. 8,11 ± 1,81 cm/s, p = 0,002; NPS: 6,64 ± 1,51 vs. 7,72 ± 1,44 cm/s, p = 0,003, medidas pela fração de ejeção ventricular esquerda e Doppler tecidual, respectivamente. O SIL, ao contrário do NPS, apresentou melhora no índice de saturação venosa de oxigênio, medido pela gasometria venosa. CONCLUSÃO: Sildenafil e NPS são vasodilatadores que reduzem, de forma significativa, a hipertensão pulmonar e a geometria cardíaca, além de melhorar a função biventricular. O NPS, ao contrário do SIL, esteve associado a hipotensão arterial sistêmica e piora da saturação venosa de oxigênio.

Evaluation of machining effect for the residual stress of SA508 by hole drilling method

International Nuclear Information System (INIS)

Lee, Jeong Kun; Lee, Kyoung Soo; Song, Ki O; Kim, Young Shin

2009-01-01

Residual stresses on a surface of the material are welcome or undesirable since it's direction, compression or tensile. But especially for the fatigue, it is not negligible effect on the material strength. These residual stresses developed during the manufacturing processes involving material deformation, heat treatment, machining. The object of this paper is verifying the effect of machining what is mostly used for SA508. For verifying the effect of machining, three different kind of machining have been achieved, milling, grinding, wire cutting. Also to measure the residual stress, hole drill method and indentation method are used.

Transplante experimental cardíaco heterotópico e cutâneo em camundongos Experimental heterotopic cardiac and cutaneous transplantation in mice

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Patrícia Sestrheim

2005-06-01

Full Text Available OBJETIVO: Estudo experimental com o objetivo de desenvolver e avaliar a viabilidade das técnicas de transplante experimental cardíaco heterotópico abdominal vascularizado e cutâneo em camundongos, criando um instrumento para investigação da eficácia de soluções de preservação, novas drogas imunossupressoras, agentes biológicos, terapia gênica e indução de tolerância imunológica. MÉTODO: Para este estudo, as técnicas utilizadas foram descritas previamente por Corry et al. e Billingham et al. RESULTADOS: O tempo cirúrgico total para a realização dos transplantes cardíacos (n=20 foi, em média, 60,3±6,3 minutos e para os transplantes cutâneos (n=20, 17,75±0,71 minutos. A média de sobrevida dos aloenxertos cutâneos (n=34 e cardíacos (n=24 foi, respectivamente, 7 e 11 dias, enquanto que os isoenxertos sobreviveram por mais de 100 dias. CONCLUSÕES: Ambas as técnicas se caracterizaram pela fácil reprodutibilidade dos modelos experimentais. As diferenças entre as técnicas não se limitaram às peculiaridades metodológicas ou ao tempo de sobrevida e vascularização, mas principalmente à sua imunogenicidade e suscetibilidade à rejeição.OBJECTIVE: This is an experimental study which aims at developing and evaluating the feasibility of experimental techniques of vascularized and cutaneous abdominal heterotopic heart transplant in mice, creating an instrument of investigation for the effectiveness of prservation solutions, new immunosuppressive drugs, biological agents, genetic therapy and induction of immunological tolerance. METHOD: The techniques used in this work were previously described by Corry et al. and Billingham et al. RESULTS: The total surgical time to perform the cardiac transplants (n=20 was on average 60.3+6.3 minutes and the time of cutaneous transplants (n= 20 17.75+0.71 minutes. The average survival of the cutaneous allografts (n=34 and cardiac (n=24 allografts was 7 and 11 days, respectively, while

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels

OpenAIRE

Marcet, Brice; Becq, Frédéric; Norez, Caroline; Delmas, Patrick; Verrier, Bernard

2004-01-01

Cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel is defective during cystic fibrosis (CF). Activators of the CFTR Cl− channel may be useful for therapy of CF. Here, we demonstrate that a range of general anesthetics like normal-alkanols (n-alkanols) and related compounds can stimulate the Cl− channel activity of wild-type CFTR and delF508-CFTR mutant.The effects of n-alkanols like octanol on CFTR activity were measured by iodide (125I) efflux and patch-clamp techniques o...

Tamponamento cardíaco como uma das primeiras manifestações do lúpus eritematoso sistêmico

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Michelle keiko Molina

2012-09-01

Full Text Available O Lúpus Eritematoso Sistêmico (LES é uma doença autoimune de causa desconhecida que pode produzir apresentações clínicas variáveis, com períodos de remissões e de recaídas. O diagnóstico é confirmado pela presença de quatro dos onze critérios clínicos e/ou laboratoriais (erupção malar, erupção discoide, fotossensibilidade, úlceras da mucosa oral, artrite, serosite, distúrbio renal, distúrbio neurológico, distúrbio hematológico, distúrbio imunológico e anticorpo antinuclear. Dentre as manifestações cardiovasculares, o derrame pericárdico e a pericardite clínica são observados na maioria dos pacientes. Porém, o tamponamento cardíaco é raro como manifestação clínica.

Grazing incidence synchrotron X-ray diffraction and Moessbauer spectroscopy analyses of plasma nitrided ASTM F138 stainless steel

Energy Technology Data Exchange (ETDEWEB)

Souza, Danilo Olzon Dionysio de; Ardisson, Jose Domingos, E-mail: dolzon@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Silva, Edilaine Honorio [Studiecentrum voor Kernenergie (Belgium); Olzon-Dionysio, Maristela; Souza, Sylvio Dionysio de; Fabris, Jose Domingos [Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG (Brazil); Martinez, L.G. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2016-07-01

Full text: systematic investigation of samples of plasma-nitriding austenitic stainless steels ASTM F138 and AISI 316L is reported. The surface treatment of the steels through plasma-nitriding was used to improve further the hardness, wear and corrosion resistance of these stainless steels. The resulting layered crystallographic structure actually corresponds to several phases with close cell parameters, making their identification and quantification a real experimental challenge. The ASTM F138 and AISI 316L stainless steel disks were plasma nitrided for 4 h at 400 deg C in a 80% H{sub 2} -20% N2 atmosphere at 6 torr, using plasma current frequencies between 6 and 100 kHz. Data of Moessbauer (CEMS and CXMS) and grazing incidence synchrotron X-ray diffraction (XRD-SR) were systematically collected. The nitrided layer thickness were not in general influenced by the plasma frequency, except at 12 kHz, which produced a layer thickness of approximately 8.0 mm, being in average 40% thicker than for the other samples. CXMS and CEMS Moessbauer spectra for this 12 kHz-sample show a much more pronounced magnetic resonance lines than for the other samples. The Fe{sub 4}N phase presents a single magnetic hyperfine interaction; the other two (Fe{sub 2-3}N and the expanded austenite) present both paramagnetic and magnetic components, even though their hyperfine parameters may not be safely separated. We also present the results of XRD-SR that were probed at several depths. The data from these techniques may be consistently correlated and this leads to an improved model to explain the structure of the nitrided layers. (author)

Sensitization Behavior of Type 409 Ferritic Stainless Steel: Confronting DL-EPR Test and Practice W of ASTM A763

Science.gov (United States)

Scalise, Taís Campos; de Oliveira, Mara Cristina Lopes; Sayeg, Isaac Jamil; Antunes, Renato Altobelli

2014-06-01

Stainless steels employed for manufacturing automotive exhaust systems must withstand severe thermal cycles, corrosive environment due to urea decomposition, and welding operations. AISI 409 ferritic stainless steel can be considered a low-cost alternative for this application. However, depending on the manufacturing conditions during welding cycles, this material can be sensitized due to the precipitation of chromium carbides at grain boundaries. In this work, the intergranular corrosion resistances of the AISI 409 ferritic stainless steel were evaluated after annealing at 300, 500, and 700 °C for 2, 4, and 6 h. Solution-annealed samples were also tested for comparison purposes. Two methodologies were used to assess the sensitization behavior of the 409 stainless steel samples: the first one was based on the ASTM A763 (practice W), while the second one was based on the double-loop electrochemical potentiodynamic reactivation test. It was possible to identify that the annealing treatment performed at 500 °C was more critical to the occurrence of intergranular corrosion.

Evaluation of ozonated water using ASTM E1174 for standardized testing of handwash formulations for healthcare personnel.

Science.gov (United States)

Nakamura, K; Saito, K; Kashiwazaki, J; Aoyagi, T; Arai, K; Hara, Y; Kobari, S; Mori, H; Ohashi, K; Takano, Y; Kaku, M; Kanemitsu, K

2018-02-13

Removal of bacteria by handwashing with ozonated water was evaluated using the ASTM E1174 standard test method. Thirty healthy volunteers were assigned randomly to three groups: ozonated water, antimicrobial soap and water, and non-antimicrobial soap and water. A 3 log 10  cfu reduction was achieved by washing hands with ozonated water or antimicrobial soap and water. However, ozonated water was not significantly superior to non-antimicrobial soap and water. Ozonated water may remove bacteria from the hands to at least a similar extent as that by non-antimicrobial soap and water in the absence of visible dirt or body fluid contamination. Copyright © 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Avaliação da doença vascular do enxerto no transplante cardíaco: experiência de um centro brasileiro Assessment of cardiac allograft vasculopathy in cardiac transplantation: experience of a Brazilian center

Directory of Open Access Journals (Sweden)

Elide Sbardellotto Mariano da Costa

2012-10-01

Full Text Available FUNDAMENTO: O transplante cardíaco continua sendo o tratamento de escolha para a insuficiência cardíaca refratária ao tratamento otimizado. Dois métodos diagnósticos apresentam elevada sensibilidade no diagnóstico de episódios de rejeição ao enxerto e Doença Vascular do Enxerto (DVE, causas importantes de mortalidade no pós-transplante. OBJETIVO: Avaliar a relação entre os resultados do ultrassom intracoronariano (USIV e os laudos das biópsias endomiocárdicas (BX no seguimento de pacientes submetidos a transplante cardíaco em um serviço de referência brasileiro. MÉTODOS: Foi realizado um ensaio epidemiológico retrospectivo observacional, com pacientes submetidos a transplante cardíaco ortotópico, no período de 2000 a 2009. Foram analisados os prontuários desses pacientes e os resultados dos USIV e BX realizados rotineiramente no seguimento clínico pós-transplante e terapêutica em uso. RESULTADOS: Dos 77 pacientes analisados, 63,63% são do sexo masculino, nas faixas etárias de 22 a 69 anos. Quanto aos resultados dos USIV, 33,96% foram classificados em Stanford classe I, e 32,08%, como Stanford IV. Dos 143 laudos das biópsias, 51,08% tiveram resultado 1R, 3R em 0,69% dos laudos, e 14,48% apresentaram a descrição de efeito Quilty. Todos usaram antiproliferativos, 80,51% usaram inibidores da calcineurina e 19,48% usaram inibidores do sinal de proliferação (ISP. CONCLUSÃO: A avaliação dos pacientes pós-transplante cardíaco por meio do USIV incorpora informações detalhadas para o diagnóstico precoce e sensível da DVE, que são complementadas pelas informações histológicas fornecidas pelas BX, estabelecendo uma possível relação causal entre a DVE e os episódios de rejeição humoral.BACKGROUND: Cardiac transplantation continues to be the treatment of choice for heart failure refractory to optimized treatment. Two methods have high sensitivity for diagnosing allograft rejection episodes and cardiac

Primary cardiac lymphoma in dogLinfoma cardíaco primário em cão

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Mirela Tinucci Costa

2013-10-01

Full Text Available Lymphomas are malignant neoplasm characterized by proliferation of lymphocytes that originate primarily in lymphoid organ such as lymph nodes, liver, spleen and bone marrow. However the feature of continuous migration of lymphocytes in different organs, this tumor can develop in any organ. Although lymphoma is a very common hematopoietic neoplasm in dogs, cardiac location is rare. The diagnosis of primary cardiac lymphoma may be performed when there is involvement of the heart and / or the pericardium without evidence of involvement in other organs. In veterinary medicine there are few reports on the diagnosis, treatment and prognosis of cardiac lymphoma. Therefore, the purpose of this report is to describe a case of cardiac lymphoma in which the patient responded favorably to chemotherapy employee with disease-free interval of 19 months and highlight the importance of including this neoplasm in the differential diagnosis of diseases that affect the cardiovascular system. Os linfomas são neoplasias caracterizadas pela proliferação maligna de linfócitos, que originamse principalmente em órgão linfóides como linfonodos, fígado, baço e medula óssea. Entretanto pela característica de contínua migração dos linfócitos por diferentes órgãos, esta neoplasia pode se desenvolver em qualquer órgão. Embora o linfoma seja a neoplasia hematopoiética de maior incidência em cães, a localização cardíaca é rara. O diagnóstico de linfoma cardíaco primário pode ser realizado quando há envolvimento do coração e/ou pericárdio sem evidências de ocorrência de órgãos linfáticos ou extranodais. Em medicina veterinária existem poucos relatos sobre o diagnóstico, tratamento e prognóstico desta neoplasia cardíaca. Portanto o objetivo do presente relato é descrever um caso de linfoma cardíaco em que o paciente respondeu favoravelmente ao tratamento quimioterápico empregado com intervalo livre de doença de 19 meses e salientar a

Fracture toughness determination of the pressure vessel steel A508 Cl 2 between 100 and 350 degree C

International Nuclear Information System (INIS)

Rao, S.

1980-09-01

The fracture toughness of the pressure vessel steel A508 was determined in the temperature range 100 - 350 degree C. The J-integral method with crack growth resistance curves, the so-called R-curves, was used. The results show that the steel does not have an 'upper-shelf' and the fracture toughness, K sub (JC), decreases with increasing temperature to a minimum around 300 degree C and an increase above it. These results are compared to those obtained previously on an other pressure vessel steel A533B which has essentially the same temperature dependence. The results were also analysed using the Tearing modulus, T. The conclusion iw that the crack growth resistance and the crack initiation resistance (K sub (JC)) show a significant decrease around the operating temperatures as compared to 100 degree C. (author)

Effects on Machining on Surface Residual Stress of SA 508 and Austenitic Stainless Steel

International Nuclear Information System (INIS)

Lee, Kyoung Soo; Lee, Seong Ho; Park, Chi Yong; Yang, Jun Seok; Lee, Jeong Geun; Park, Jai Hak

2011-01-01

Primary water stress corrosion cracking has occurred in dissimilar weld areas in nuclear power plants. Residual stress is a driving force in the crack. Residual stress may be generated by weld or surface machining. Residual stress due to surface machining depends on the machining method, e.g., milling, grinding, or EDM. The stress is usually distributed on or near the surface of the material. We present the measured residual stress for machining on SA 508 and austenitic stainless steels such as TP304 and F316. The residual stress can be tensile or compressive depending on the machining method. The depth and the magnitude of the residual stress depend on the material and the machining method

Consulta de enfermagem ao cliente transplantado cardíaco: impacto das ações educativas em saúde Consulta de Enfermería al cliente trasplantado cardíaco: impacto de las acciones en salud Appointment with nurses for transplanted heart clients: impact of educative health actions

Directory of Open Access Journals (Sweden)

Zélia Maria de Sousa Araújo Santos

2004-12-01

Full Text Available O estudo teve como objetivo avaliar o impacto das ações educativas em saúde, na consulta de Enfermagem com 18 clientes transplantados cardíacos, embasado na Teoria de Orem. Foi realizado em uma Unidade de Transplante e Insuficiência Cardíaca de uma Instituição Pública de Saúde de Fortaleza - Ce. Os dados foram coletados através da consulta de Enfermagem. Identificou-se 14 diagnósticos de enfermagem na primeira consulta e 7 na última. Constatou-se que, os clientes desenvolveram habilidades para o autocuidado, com a implementação das ações educativas em saúde, tornando-os agentes de autocuidado, com o alcance de um bom nível de saúde e bem-estar. Por outro lado, despertou no enfermeiro, um direcionamento sistemático e eficaz no acompanhamento ambulatorial a esta clientela.El estudio tiene como objetivo, evaluar el impacto de las acciones educativas en salud, en la consulta de Enfermería con 18 cliente trasplantados cardíacos, basado en la teoría de Orem. Se realizó en una Unidad de Trasplante e Insuficiencia Cardiaca de una Institución Pública de Fortaleza-Ce. Se colectaron los datos a través de consulta de enfermería. Se identificaron 14 diagnósticos en la primera consulta y 7 en la última. Hubo la constatación de que, los clientes desarrollaron habilidades para el autocuidado, con la implementación de las acciones educativas en salud, volviéndose agentes de autocuidado, con el alcance de un buen nivel de salud y bienestar. Por otro lado, estimuló en el enfermero, una dirección sistemática y eficaz en el acompañamiento ambulatorial a esta clientela.The study was aimed at evaluating the impact of educative health actions on nursing appointments with 18 transplanted heart clients, based on Orem's Theory. It was conducted in a Heart Transplant and Insufficiency Unit of a Public Health Institution in Fortaleza - CE. The data were collected by way of nursing appointments. 14 nursing diagnoses were identified in

Avaliação das propriedades termo-mecânicas de borracha nitrílica após ensaio de compatibilidade de acordo com ASTM D 3455 Thermal-mechanical properties evaluation of nitrilic rubber after compatibility test according to ASTM D 3455

Directory of Open Access Journals (Sweden)

Adailze L. Meyer

2006-01-01

Full Text Available O copolímero butadieno - acrilonitrila - NBR é comumente aplicado na confecção de gaxetas e anéis de vedação para transformadores elétricos isolados a óleo mineral. Durante o uso esses materiais permanecem em contato com óleo em temperaturas próximas a 90 ºC provocando alterações físicas e químicas no material elastomérico e no óleo. Neste trabalho, estudou-se a variação das propriedades mecânicas do elastômero resultantes do ensaio de compatibilidade (ASTM D 3455[3]. A caracterização mecânica foi realizada por ensaios de resistência a tração, dureza e análise dinâmico-mecânica (DMA. A verificação da estabilidade térmica e a composição do NBR foram obtidas através de análise termogravimétrica (TGA.The copolymer of acrylonitrile and butadiene - NBR is commonly used to manufacture gaskets and seals to be used in electrical transformers insulated by mineral oil. During operation those materials are constantly in contact with oil at temperatures that can reach 90 ºC, causing physical and chemicals changes in both gaskets and oil. In this paper the changes in elastomer mechanical properties after the compatibility test were studied (ASTM D 3455[3]. This characterization was done by tension properties, hardness and dynamical mechanical analysis (DMA. The evaluation of thermal stability and composition of the NBR was carried out through thermogravimetry analysis (TG.

Ethical challenges for accountable care organizations: a structured review.

Science.gov (United States)

DeCamp, Matthew; Farber, Neil J; Torke, Alexia M; George, Maura; Berger, Zackary; Keirns, Carla C; Kaldjian, Lauris C

2014-10-01

Accountable care organizations (ACOs) are proliferating as a solution to the cost crisis in American health care, and already involve as many as 31 million patients. ACOs hold clinicians, group practices, and in many circumstances hospitals financially accountable for reducing expenditures and improving their patients' health outcomes. The structure of health care affects the ethical issues arising in the practice of medicine; therefore, like all health care organizational structures, ACOs will experience ethical challenges. No framework exists to assist key ACO stakeholders in identifying or managing these challenges. We conducted a structured review of the medical ACO literature using qualitative content analysis to inform identification of ethical challenges for ACOs. Our analysis found infrequent discussion of ethics as an explicit concern for ACOs. Nonetheless, we identified nine critical ethical challenges, often described in other terms, for ACO stakeholders. Leaders could face challenges regarding fair resource allocation (e.g., about fairly using ACOs' shared savings), protection of professionals' ethical obligations (especially related to the design of financial incentives), and development of fair decision processes (e.g., ensuring that beneficiary representatives on the ACO board truly represent the ACO's patients). Clinicians could perceive threats to their professional autonomy (e.g., through cost control measures), a sense of dual or conflicted responsibility to their patients and the ACO, or competition with other clinicians. For patients, critical ethical challenges will include protecting their autonomy, ensuring privacy and confidentiality, and effectively engaging them with the ACO. ACOs are not inherently more or less "ethical" than other health care payment models, such as fee-for-service or pure capitation. ACOs' nascent development and flexibility in design, however, present a time-sensitive opportunity to ensure their ethical operation

Evolução hemodinâmica seqüencial no transplante cardíaco Sequential hemodynamic evaluation in heart transplantation

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Noedir A. G Stolf

1988-12-01

Full Text Available O transplante cardíaco tem tido ampla aplicação no tratamento da cardiomiopatia em fase terminal. Grande interesse existe no estudo das alterações hemodinâmicas imediatas e na identificação dos fatores que determinam essas alterações. Quarenta e três pacientes transplantados foram estudados com esse objetivo. Os seguintes dados foram obtidos: índice cardíaco, as pressões nas câmaras cardíacas, capilar pulmonar, aorta, artéria pulmonar, volume sistólico, fração de ejeção do ventrículo esquerdo (VE, resistência vascular pulmonar e sistêmica, índice do trabalho sistólico do ventrículo esquerdo e direito (VD e o tríplice produto. Esses valores foram comparados de acordo com os episódios de rejeição e com diferentes valores do gradiente transpulmonar. Verificou-se que no pós-operatório imediato há depressão da função dos ventrículos decorrente de uma série de fatores. O índice cardíaco se mantém em valore adequados através de vários mecanismos e adaptação dos ventrículos, que ocorre mais precocemente para o VE do que para o VD. Tardiamente as alterações hemodinâmicas dependem do aparecimento de hipertensão arterial sistêmica e da aterosclerose coronária. A presença e os valores mais elevados do gradiente transpulmonar não tiveram influência estatisticamente significativa nas condições hemodinâmicas dos pacientes.heart transplantation has been widely employed in treatment of end stage cardiomyopathy. Great interest exists in the study of early and late hemodynamic alterations following the procedure. Fourty three patients submited to heart transplantation were studied with this aim. The data obtained were: cardiac index, pressure in the heart chambers, capillary wedge pressure, aorta and pulmonary artery pressure, systolic volume and ejection fraction of left ventricle, pulmonary and systemic vascular resistances; left and right work systolic indexes; triple product. The data were compared in

Cladding nuclear steels - the application of plasma-arc hot wire surfacing

International Nuclear Information System (INIS)

Trarbach, K.O.

1981-01-01

The effect of one and two layer plasma-arc hot wire cladding on the HAZ microstructure of the fine grained structural steel 22 NiMoCr 3 7, which is similar to ASTM A 508, class 2, and steel 20 MnMoNi 5 5, similar to ASTM A 533, grade B, class 1 is determined. Attention is directed particularly to the behaviour of the susceptible region, and the consumables considered are cladding materials X 2 CrNiNb 19 9, similar to ER 347 Elc, and S-NiCr 20 Nb, similar to ER NiCr-3 (Inconel 82). Results of corrosion resistance tests show that this cladding technique can be recommended for manufacture of equipment for the chemical industry to avoid corrosion failure. Plasma-arc hot wire surfacing is also shown to be capable of depositing single or double clad layers to meet the highest safety requirements and could be applied to nuclear power plants for the special manufacture of wear resistant parts and for protection of equipment subject to a variety of corrosive environments. (U.K.)

Análisis acústico sobre señales de auscultación digital para la detección de soplos cardíacos

OpenAIRE

CASTAÑO, ANDRÉS M.; DELGADO T., EDILSON; GODINO, JUANI; CASTELLANOS, GERMÁN

2009-01-01

Se presenta la metodología basada en el análisis acústico de señales fonocardiográficas (FCG) par a detectar soplos cardíacos. En primer lugar se desarrolla un sistema de filtración basado en la transformada wavelet para reducir las perturbaciones que usualmente se presentan en la etapa de adquisición, ajustando la calidad del sonido de acuerdo a los requerimientos clínicos y validados por especialistas en semiología. Se propone un algoritmo de segmentación basado en la energía promedio norm...

Prediction of fracture toughness K/sub Ic/ of steel from Charpy impact test results

Energy Technology Data Exchange (ETDEWEB)

Iwadate, Tadao; Tanaka, Yasuhiko; Takemata, Hiroyuki; Terashima, Shuhei

1986-08-01

This paper presents a method to predict the fracture toughness K/sub Ic/ and/or K/sub Id/ of steels using their Charpy impact test results and tensile properties. The fracture toughness, Charpy impact and tensile properties of 2 1/4 Cr-1Mo, ASTM A508 Cl.1, A508 Cl.2 A508 Cl.3 and A533 Gr.B Cl.1 steels were measured and analysed on the basis of the excess temperature (test temperature minus FATT) and Rolfe-Novak correlation. The relationship between K/sub Ic//K/sub Ic-us/ and the excess temperature, where K/sub Ic-us/ is the upper-shelf fracture toughness K/sub Ic/ predicted by Rolfe-Novak correlation, discloses that the K/sub Ic/ transition curves of several steels are representable by only one trend curve of K/sub Ic//K/sub Ic-us/ or K/sub Id//K/sub Id-us/ versus excess temperature relation. This curve is denoted as a ''master curve''. By using this curve, the fracture toughness of steel can be predicted using Charpy impact and tensile test results. By taking account of the scattering of both the fracture toughness and Charpy impact test results, the confidence limits of the master curve were also determined. Another approach to develop more general procedure of predicting the fracture toughness K/sub Ic/ is also discussed.

High-cycle notch sensitivity of alloy steel ASTM A743 CA6NM used in hydrogenator turbine components

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José Alexander Araújo

2010-10-01

Full Text Available The presence of notches and other stress concentrations in turbine blades and other notch hydraulic components is a current problem in engineering. It causes a reduction of endurance limit of material. In that sense, specimens of the ASTM A743 CA6NM alloy steel using in several hydrogenator turbine components was tested. The specimens were tested under uniaxial fatigue loading with a load ratio equal to -1, and the considered stress concentration factors, Kt, values, calculated with respect to net area, were 1.55, 2.04 and 2.42. In order to determine the fatigue limit for such notch type, a reduction data method by Dixon and Mood, Staircase method was used. This approach is based on the assumed target distribution of the fatigue limit. For such geometry at least 8 specimens were tested. In addition, the Peterson and Neuber’s notch fatigue factor were compared through fatigue notch reduction factor, Kf, obtained from experimental data. According to results obtained it was possible to conclude that the tested material is less sensitive to notches than the prediction of the Peterson and Neuber’s empirical models.

Aplicación de un algoritmo ACO al problema de taller de flujo de permutación con tiempos de preparación dependientes de la secuencia y minimización de makespan An ant colony algorithm for the permutation flowshop with sequence dependent setup times and makespan minimization

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Eduardo Salazar Hornig

2011-08-01

Full Text Available En este trabajo se estudió el problema de secuenciamiento de trabajos en el taller de flujo de permutación con tiempos de preparación dependientes de la secuencia y minimización de makespan. Para ello se propuso un algoritmo de optimización mediante colonia de hormigas (ACO, llevando el problema original a una estructura semejante al problema del vendedor viajero TSP (Traveling Salesman Problem asimétrico, utilizado para su evaluación problemas propuestos en la literatura y se compara con una adaptación de la heurística NEH (Nawaz-Enscore-Ham. Posteriormente se aplica una búsqueda en vecindad a la solución obtenida tanto por ACO como NEH.This paper studied the permutation flowshop with sequence dependent setup times and makespan minimization. An ant colony algorithm which turns the original problem into an asymmetric TSP (Traveling Salesman Problem structure is presented, and applied to problems proposed in the literature and is compared with an adaptation of the NEH heuristic. Subsequently a neighborhood search was applied to the solution obtained by the ACO algorithm and the NEH heuristic.

Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non toxic modified pyrrolo[2,3-b]pyrazine derivatives

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Luc eDannhoffer

2011-08-01

Full Text Available Cystic Fibrosis is a major inherited disorder involving abnormalities of fluid and electrolyte transport in a number of different organs due to abnormal function of Cystic Fibrosis Transmembrane conductance Regulator (CFTR protein. We recently identified a family of CFTR activators, which contains the hit: RP107 [7-n-butyl-6-(4-hydroxyphenyl[5H]-pyrrolo[2,3-b]pyrazine]. Here, we further evaluated the effect of the chemical modifications of the RP107-OH radical on CFTR activation. The replacement of the OH radical by a fluorine atom at position 2 (RP193 or 4 (RP185 significantly decreased the toxicity of the compounds without altering the ability to activate CFTR, especially for RP193. The non-toxic compound RP193 has no effect on cAMP production but stimulates the channel activity of wild-type CFTR in stably transfected CHO cells, in human bronchial epithelial NuLi-1 cells and in primary culture of human bronchial epithelial cells. Whole cell and single patch clamp recordings showed that RP193 induced a linear, time and voltage-independent current, which was fully inhibited by two different and selective CFTR inhibitors (CFTRinh-172 and GPinh-5a. Moreover, RP193 stimulates CFTR in temperature-rescued CuFi-1 (F508del/F508del human bronchial epithelial cells and in CHO cells stably expressing G551D-CFTR. This study shows that it is feasible to reduce cytotoxicity of chemical compounds without affecting their potency to activate CFTR and to rescue the class 2 F508del-CFTR and class 3 G551D-CFTR CF mutant activities.

Determination of the sensitization of two coatings by steel welding 308l by the EPR-Dl and Astm A-262 practice A techniques; Determinacion de la sensibilizacion de dos revestimientos por soldadura de acero 308L por las tecnicas EPR-DL y ASTM A-262 practica A

Energy Technology Data Exchange (ETDEWEB)

Arganis J, C. R.; Zenteno S, J. C.; Robles F, J. L.; Rodriguez M, E.; Vazquez P, A., E-mail: carlos.arganis@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

2014-10-15

A stainless steel 308l coating was deposited by the shielded metal arc welding (SMAW) on steel A36 with a thickness of 4.726 mm in three layers. The sensitization was measured with the technique of Electrochemical Potentiodynamic Reactivation of Double-loop (EPR-Dl), using a portable cell and other of conventional window. The standard Astm A-262, practice A was used to verify the sensitization values. Two samples were used, a welding on a plate of 323 x 172 x 76.2 mm and the second welding on the end of a plate of 12.7 mm of thickness and 280 mm of longitude, with a post-welding process with gas tungsten arc welding (GTAW) with electrode ERNiCr{sub 3} and a process SMAW with electrode ENICRFe{sub 3}. The coating on the plate showed low values of sensitization grade (DOS) in all the points, indicating a very quick heat extraction and an inter dendritic structure type step. The second sample presented DOS values that are related with a structure of low sensitization and the influence of the heat of the post-welding process and a structure of recrystallized grains. (Author)

Ação do resveratrol sobre proteoglicanos de membrana presentes no músculo cardíaco em modelo animal de cardiomiopatia diabética

OpenAIRE

Paula Lazara Cruz

2016-01-01

Introdução: Ratos com diabetes induzido por estreptozotocina (STZ) apresentam alterações nos proteoglicanos Sindecan-4 e Glipican-1 no tecido cardíaco concomitantes à instalação da disfunção diastólica, evento precoce que culmina na cardiomiopatia diabética. O uso de resveratrol (RSV) em modelos animais foi capaz de melhorar a função cardíaca e o controle autonômico. Espera-se que o tratamento com esse flavonoide atue nos níveis alterados dos proteoglicanos em animais diabéticos. Objetivo: Av...

Private sector accountable care organization development: a qualitative study.

Science.gov (United States)

Scheck McAlearney, Ann; Hilligoss, Brian; Song, Paula H

2017-03-01

To explore accountable care organizations (ACOs) as they develop in the private sector, including their motivation for development, perspectives from consumers regarding these emerging ACOs, and the critical success factors associated with ACO development. Comprehensive organizational case studies of 4 full-risk private sector ACOs that included in-person interviews with providers and administrators and focus groups with local consumers. Sixty-eight key informant interviews conducted during site visits, supplemented by document collection and telephone interviews, and 5 focus groups were held with 52 consumers associated with the study ACOs. We found 3 main motivators for private sector ACO development: 1) opportunity to improve quality and efficiency, 2) potential to improve population health, and 3) belief that payment reform is inevitable. With respect to consumer perspectives, consumers were unaware they received care from an ACO. From the perspectives of ACO stakeholders, these ACOs noted that they prefer to focus on patients' relationships with providers and typically do not emphasize the ACO name or entity. Critical success factors for private sector ACO development included provider engagement, strategic buy-in, prior experience managing risk, IT infrastructure, and leadership, all meant to shift the culture to a focus on value instead of volume. These organizations perceived that pursuing an accountable care strategy allowed them to respond to policy changes anticipated to impact the way healthcare is delivered and reimbursed. Increased understanding of factors that have been important for more mature private sector ACOs may help other healthcare organizations as they strive to enhance value and advance in their ACO journeys.

Effects of thermal treatments on protein adsorption of Co-Cr-Mo ASTM-F75 alloys.

Science.gov (United States)

Duncan, L A; Labeed, F H; Abel, M-L; Kamali, A; Watts, J F

2011-06-01

Post-manufacturing thermal treatments are commonly employed in the production of hip replacements to reduce shrinkage voids which can occur in cast components. Several studies have investigated the consequences of these treatments upon the alloy microstructure and tribological properties but none have determined if there are any biological ramifications. In this study the adsorption of proteins from foetal bovine serum (FBS) on three Co-Cr-Mo ASTM-F75 alloy samples with different metallurgical histories, has been studied as a function of protein concentration. Adsorption isotherms have been plotted using the surface concentration of nitrogen as a diagnostic of protein uptake as measured by X-ray photoelectron spectroscopy. The data was a good fit to the Langmuir adsorption isotherm up to the concentration at which critical protein saturation occurred. Differences in protein adsorption on each alloy have been observed. This suggests that development of the tissue/implant interface, although similar, may differ between as-cast (AC) and heat treated samples.

Investigating the effect of coil model losses on computational electromagnetic exposure of an ASTM phantom at 64 MHz MRI.

Science.gov (United States)

Kozlov, Mikhail; Horner, Marc; Kainz, Wolfgang; Angelone, Leonardo M

2017-07-01

The goal of this work is to investigate the effect of coil losses on the electromagnetic field generated in an ASTM phantom by a birdcage coil. The study was based on different numerical implementations of an RF body coil at 64 MHz, using the same 3D EM and RF circuit co-simulation procedure. The coil quality factor was evaluated with respect to losses due to power feed mismatch and to resistive losses of the coil components. The results of the study showed that the magnetic field at the coil iso-center, normalized to the square root of the whole body specific absorption rate, depends on the coil quality factor.

Transplante cardíaco humano: experiência inicial Human cardiac transplant: initial experience

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Noedir A. G Stolf

1986-12-01

Full Text Available No Instituto do Coração, de março de 1985 a fevereiro de 1986,11 pacientes foram submetidos a transplante cardíaco ortotópico. Eram todos do sexo masculino, com idade variando de 39 a 54 anos; 6 com cardiopatia isquémica, 4 com cardiomiopatia dilatada e um com cardiomiopatia chagásica. Foi realizado estudo hemodinâmico através de catéter de Swan-Ganz, no pré-operatório, no pós-operatório, após estabilização na unidade de recuperação, e trinta ou mais dias após o transplante. Os dados mostram melhora progressiva em relação ao índice cardíaco, pressão em artéria pulmonar, pressão de capilar pulmonar, resistência vascular pulmonar e resistência vascular sistêmica. Três dos 11 pacientes apresentaram disfunção renal transitória no pós-operatório imediato e que regrediram até o 15º dia, enquanto que 2 pacientes apresentaram aumento moderado da creatinina plasmática. Apenas 3 pacientes não apresentaram qualquer episódio de rejeição; nos demais, esses episódios foram um diagnóstico histológico sem repercussões clínicas. Complicações infecciosas ocorreram em 9 pacientes e foram de fácil controle clínico. No pós-operatório tardio, a hipertensão esteve presente em 8 pacientes, sendo mais acentuada em 2 deles. Não houve óbitos, nesta série de pacientes; todos estão assintomáticos e os 6 primeiros estão trabalhando.At the Instituto do Cora��ão, University of São Paulo Medical School, 11 patients were submitted to heart transplantation from march 1985 up to february 1986. All were male, with ages of 39-59 years, 6 with coronary heart disease, 4 with dilated cardiomyopathy and 1 with Chagas cardiomyopathy. The patients were studied hemodynamically with a Swan-Ganz catheter pre-operatively, at the arrival in the intensive care unit, in the first postoperative day and 30 or more days after the transplant. The data showed that there was a progressive increase of cardiac index and decreases of

INFRASTRUCTURAL MECHANISMS LEADING TOWARD PRO-ACCOUNTABLE CARE ORGANISATION ORIENTATION: A SURVEY OF HOSPITAL MANAGERS

Science.gov (United States)

Wan, Thomas T.H.; Masri, Maysoun Dimachkie; Ortiz, Judith

2013-01-01

Organisations across the country are transforming the way they deliver care, in ways similar to the accountable care organisation (ACO) model supported by Medicare. ACOs modalities are varying in size, type, and financing structure. Little is known about how specific infrastructural mechanisms influence hospital managers’ pro-ACO orientation. Using an electronic-survey of hospital managers, this study explores how pro-ACO orientation, as a latent construct, is captured from the perceptions of hospital managers; and identify infrastructural mechanisms leading to the formation of pro-ACO orientation. Of the total hospital respondents, 58% are moving toward the establishment of ACOs; 56% are planning to join in the next two years; 48% are considering joining ACOs; while 25% had already participated in ACOs during 2012. Urban hospitals are more likely than rural hospitals to be engaged in ACO development. The health provider network size is one of the strongest indicators in predicting pro-ACO orientation. PMID:25374609

The correlation between accelerated and field corrosion tests performed in carbon steel and weathering steel coupons, coated and non-coated; Correlacao entre ensaios acelerados e ensaios de campo em corpos-de-provas de aco carbono e aco patinavel, sem e com revestimento

Energy Technology Data Exchange (ETDEWEB)

Antunes, Renato Altobelli

2002-07-01

The performance of four different organic coating systems applied to carbon and weathering steel coupons has been assessed in this investigation. applied on the surface of carbon steel and weathering steel coupons. The coupons have been evaluated using five different tests, three field tests and two accelerated tests. The field tests were carried out at three atmospheric stations, located at COSIPA in Cubatao-SP, at Alto da Serra in Cubatao-SP and at Paula Souza in Sao Paulo city. The accelerated tests consisted of (a) exposure to alternate cycles of ultraviolet radiation/condensation combined with salt spray cycles (UVCON combined with Salt Spray) and of (b) exposure to alternate cycles of ultraviolet radiation/condensation combined with the Prohesion test. The performance of the coatings was assessed by visual observation and photographs, using a method based on ASTM D-610, ASTM D-714 and ASTM-1654 standards to rank them. The oxide phases formed on the surfaces of the non-coated specimens of carbon and weathering steels, exposed to the same tests performed with the coated specimens, were identified using three different techniques: X-ray diffraction, Raman microscopy and Moessbauer spectroscopy. In the field tests, the specimens have been exposed for 1, 2, 3, 6 and 9 months. In the accelerated ones, the results were obtained after 1340 hours (4 cycles) test. The main component identified in all the specimens collected from the field tests and from the UVCON combined with the Prohesion test was lepidocrocite ({gamma}-FeOOH). Goethite ({alpha}-FeOOH ) and magnetite (Fe{sub 3}O{sub 4}) were identified as the other two main phases present in ali the specimens. In the UVCON combined with Salt Spray test, the dominant phase was magnetite, followed by goethite and lepidocrocite. The morphology of the rust formed on the specimens was examined by scanning electron microscopy (SEM). Structures corresponding to goethite and lepidocrocited were recognized on ali specimens

COMPETITION BEETWEN DYNAMIC RECUPERATION AND RECRYSTALLIZATION OF ASTM F 138 AUSTENITIC STAINLESS STEEL UTILIZED IN MEDICAL DEVICES

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Fabio Henrique Casarini Geronimo

2013-06-01

Full Text Available ASTM F 138 austenitic stainless steel has being used in the manufacture of orthopedical devices by hot forging. In this work, the flow stress curves are determined by hot torsion tests in a wide range of temperatures and strain rates. With the observed microestrutural evolution by optical microscopy in different hot forming conditions in addiction with EBSD (Electron Backscatter Diffraction techniques it is possible to obtained the recrystallized volume fraction and the misorientation angles of the samples. Due to the intermediate level of stacking fault energy of this material, during the dynamic softening occurs a competition between recrystallization and recovery. The aim of this work is to identify the softening mechanisms in this stainless steel, as well as in which hot work conditions they become more active.

Comparisons of ASTM standards cited in the NRC standard review plan, NUREG-0800 and related documents

International Nuclear Information System (INIS)

Ankrum, A.R.; Bohlander, K.L.; Gilbert, E.R.; Pawlowski, R.A.; Spiesman, J.B.

1995-10-01

This report provides the results of comparisons of the cited and latest versions of ASTM standards cited in the NRC Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants (NUREG 0800) and related documents. The comparisons were performed by Battelle Pacific Northwest Laboratories in support of the NRC's Standard Review Plan Update and Development Program. Significant changes to the standards, from the cited version to the latest version, are described and discussed in a tabular format for each standard. Recommendations for updating each citation in the Standard Review Plan are presented. Technical considerations and suggested changes are included for related regulatory documents (i.e., Regulatory Guides and the Code of Federal Regulations) citing the standard. The results and recommendations presented in this document have not been subjected to NRC staff review

Creep crack growth in a reactor pressure vessel steel at 360 deg C

Energy Technology Data Exchange (ETDEWEB)

Wu, Rui; Seitisleam, F; Sandstroem, R [Swedish Institute for Metals Research, Stockholm (Sweden)

1999-12-31

Plain creep (PC) and creep crack growth (CCG) tests at 360 deg C and post metallography were carried out on a low alloy reactor pressure vessel steel (ASTM A508 class 2) with different microstructures. Lives for the CCG tests were shorter than those for the PC tests and this is more pronounced for simulated heat affected zone microstructure than for the parent metal at longer lives. For the CCG tests, after initiation, the cracks grew constantly and intergranularly before they accelerated to approach rupture. The creep crack growth rate is well described by C*. The relations between reference stress, failure time and steady crack growth rate are presented for the CCG tests. It is demonstrated that the failure stress due to CCG is considerably lower than the yield stress at 360 deg C. Consequently, the CCG will control the static strength of a reactor vessel. (orig.) 17 refs.

Creep crack growth in a reactor pressure vessel steel at 360 deg C

Energy Technology Data Exchange (ETDEWEB)

Rui Wu; Seitisleam, F.; Sandstroem, R. [Swedish Institute for Metals Research, Stockholm (Sweden)

1998-12-31

Plain creep (PC) and creep crack growth (CCG) tests at 360 deg C and post metallography were carried out on a low alloy reactor pressure vessel steel (ASTM A508 class 2) with different microstructures. Lives for the CCG tests were shorter than those for the PC tests and this is more pronounced for simulated heat affected zone microstructure than for the parent metal at longer lives. For the CCG tests, after initiation, the cracks grew constantly and intergranularly before they accelerated to approach rupture. The creep crack growth rate is well described by C*. The relations between reference stress, failure time and steady crack growth rate are presented for the CCG tests. It is demonstrated that the failure stress due to CCG is considerably lower than the yield stress at 360 deg C. Consequently, the CCG will control the static strength of a reactor vessel. (orig.) 17 refs.

Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines.

Science.gov (United States)

Gonçalves, Cristine; Gomez, Jean-Pierre; Même, William; Rasolonjatovo, Bazoly; Gosset, David; Nedellec, Steven; Hulin, Philippe; Huin, Cécile; Le Gall, Tony; Montier, Tristan; Lehn, Pierre; Pichon, Chantal; Guégan, Philippe; Cheradame, Hervé; Midoux, Patrick

2017-08-01

Neutral amphiphilic triblock ABA copolymers are of great interest to solubilize hydrophobic drugs. We reported that a triblock ABA copolymer consisting of methyl-2-oxazoline (MeOx) and tetrahydrofuran (THF) (MeOx 6 -THF 19 -MeOx 6 ) (TBCP2) can solubilize curcumin (Cur) a very hydrophobic molecule exhibiting multiple therapeutic effects but whose insolubility and low stability in water is a major drawback for clinical applications. Here, we provide evidences by flow cytometry and confocal microscopy that Cur penetration in normal and ΔF508-CFTR human airway epithelial cell lines is facilitated by TBCP2. When used on ΔF508-CFTR cell lines, the Cur/TBCP2 formulation promotes the restoration of the expression of the CFTR protein in the plasma membrane. Furthermore, patch-clamp and MQAE fluorescence experiments show that this effect is associated with a correction of a Cl - selective current at the membrane surface of F508del-CFTR cells. The results show the great potential of the neutral amphiphilic triblock copolymer MeOx 6 -THF 19 -MeOx 6 as carrier for curcumin in a Cystic Fibrosis context. We anticipate that other MeOx n -THF m -MeOx n copolymers could have similar behaviours for other highly insoluble therapeutic drugs or cosmetic active ingredients. Copyright © 2017 Elsevier B.V. All rights reserved.

ASTM lights the way for tissue engineered medical products standards: jump start for combination medical products that restore biological function of human tissues.

Science.gov (United States)

Picciolo, G L; Stocum, D L

2001-01-01

Everybody hopes for better health and restoration of impaired bodily function, and now that hope is illuminated by the promise of powerful biological tools that make human cells grow and replace human tissue. ASTM Committee F04 on Medical and Surgical Materials and Devices is taking the lead by defining some of those tools as standards that can be used for the development, production, testing, and regulatory approval of medical products.

Investigação de lipofuscina em miócitos cardíacos de camundongos após tratamento com oxamniquine

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Maria Luiza Silveira Mello

1984-10-01

Full Text Available A fluorescencia natural devida à presença de corpos de lipofuscina foi pesquisada em miócitos cardíacos de camundongos adultos jovens tratados com oxamniquine. O objetivo foi buscar uma evidência de indução de envelhecimento celular precoce, com base em dados prévios de acentuação poliploidia, promovida pela droga. Comparando o miocárdio dos camundongos tratados com animais contrôle jovens e velhos, não foi observada a presença de lipofuscina nos seus miócitos. Isto possivelmente se deva a um não comprometimento da eficiência das lipases lisossomiais apesar da acentuação do fenômeno de poliploidização induzida pela droga.

Proinflammatory effect of sodium 4-phenylbutyrate in deltaF508-cystic fibrosis transmembrane conductance regulator lung epithelial cells: involvement of extracellular signal-regulated protein kinase 1/2 and c-Jun-NH2-terminal kinase signaling.

Science.gov (United States)

Roque, Telma; Boncoeur, Emilie; Saint-Criq, Vinciane; Bonvin, Elise; Clement, Annick; Tabary, Olivier; Jacquot, Jacky

2008-09-01

Sodium 4-phenylbutyrate (4-PBA) has attracted a great deal of attention in cystic fibrosis (CF) pathology due to its capacity to traffic DeltaF508-cystic fibrosis transmembrane conductance regulator (CFTR) to the cell membrane and restore CFTR chloride function at the plasma membrane of CF lung cells in vitro and in vivo. Using two different DeltaF508-CFTR lung epithelial cell lines (CFBE41o- and IB3-1 cells, characterized with DeltaF508-homozygous and heterozygous genotype, respectively) in vitro, 4-PBA induced an increase of proinflammatory cytokine interleukin (IL)-8 production in a concentration-dependent manner. This 4-PBA-induced IL-8 production was associated with a strong reduction of proteasome and nuclear factor-kappaB transcriptional activities in the two DeltaF508-CFTR lung cells either in a resting state or after tumor necrosis factor-alpha stimulation. In contrast, a strong increase of activator protein-1 transcriptional activity was observed. The inhibition of extracellular signal-regulated protein kinase 1/2 (ERK1/2) by 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene (U0126) and 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD98059) and c-Jun-NH(2)-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) by anthra[1,9-cd] pyrazol-6 (2H)-one (SP600125), respectively, was associated with a reduction (2-3.5-fold) of IL-8 production in both DeltaF508-CFTR lung cell lines treated with 4-PBA. No significant change of IL-8 production was observed after an inhibition of p38 MAPK with 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol (SB202190). Therefore, we suggest that inhibition of both ERK1/2 and JNK signaling may be a means to strongly reduce 4-PBA-induced IL-8 production in combination with 4-PBA treatment to restore CFTR Cl(-) channel function in lung epithelial cells of patients with CF.

Web Accessibility of the Higher Education Institute Websites Based on the World Wide Web Consortium and Section 508 of the Rehabilitation Act

Science.gov (United States)

Alam, Najma H.

2014-01-01

The problem observed in this study is the low level of compliance of higher education website accessibility with Section 508 of the Rehabilitation Act of 1973. The literature supports the non-compliance of websites with the federal policy in general. Studies were performed to analyze the accessibility of fifty-four sample web pages using automated…

A study of long term ageing effects in A533B Class 1 and A508 Class 3 steels

International Nuclear Information System (INIS)

Druce, S.G.

1981-08-01

The effects of long term thermal ageing treatments on notched impact fracture properties has been studied in two commercially produced PWR pressure vessel steels, A533B Class 1 and A508 Class 3. Heat treatments of up to 10,000h duration at temperatures between 300 and 600 0 C have been investigated. Additionally the effects of specimen size, specimen orientation, specimen position from within the plate and the effect of a prior post weld heat treatment on subsequent fracture behaviour following thermal ageing have been evaluated for the A533B Class 1 material. The susceptibility of both materials to temper embrittlement effects is relatively low, the maximum increase in transition temperature following thermal ageing treatments in the temperature range 300 to 500 0 C being about 40 to 45 0 C. Thermal ageing at 600 0 C for times in excess of 100h produces microstructural changes resulting in larger increases in transition temperature. For the A533B material, specimen position and orientation are found to have a large influence on impact behaviour but do not affect the susceptibility to temper embrittlement. Post weld heat treatment has little or no influence on impact fracture behaviour before further isothermal ageing treatments nor on susceptibility to temper embrittlement. (author)

Studies on the welding of heavy-section ASTM A542 Cl. 1 steel for large-sized pressure vessels

International Nuclear Information System (INIS)

Shimizu, Shigeki; Aota, Toshiichi; Kasahara, Masayuki

1977-01-01

ASTM A 542, Cl. 1 steel was developed and standardized recently, and is excellent in the high temperature strength and toughness as compared with conventionally used A 387, Grade 22 steel, accordingly the application to large pressure vessels is planned. This steel is a low alloy steel, and in case of large thickness, the possibility of cracking in the welded part is large. Also many times of annealing are required for the prevention of welding cracking, the relieving of residual stress, and the softening of hardened portion, but the possibility of cracking during stress-relieving annealing is large. In this study, Tekken type cracking test was carried out by coated electrode welding, and restricted cracking test was carried out by submerged arc welding of the A 542, Cl. 1 steel and A 387, Grade 22 steel, thus the welding cracking property was investigated, and the optimal welding conditions were selected. Also the test of cracking during the stress-relieving annealing of both steels was carried out, and the method of preventing the cracking was studied. The optimal conditions of stress-relieving annealing were selected, and the mechanism of the cracking was clarified. The mechanical properties of the joints welded and stress-relieved under the selected conditions were confirmed. (Kako, I.)

Prevalence of DF508, G551D, G542X, and R553X mutations among cystic fibrosis patients in the North of Brazil

Directory of Open Access Journals (Sweden)

Araújo F.G. de

2005-01-01

Full Text Available Cystic fibrosis (CF is the most common genetic disease among Caucasians and is rare among sub-Saharan Africans. The Brazilian population is not ethnically homogeneous but it is the result of three-way ethnic admixture of Europeans, Africans and Amerindians in varying proportions, depending on the region. In the present study, we investigated 33 patients who had been diagnosed and are currently under treatment for CF at the University Hospital João de Barros Barreto, Belém, Pará State. The molecular analysis for G542X, G551D and R553X mutations was performed by PCR followed by RFLP using BstNI, HincII and MboI, respectively, in polyacrylamide gel eletrophoresis and stained with AgNO3. ThedeltaF508 mutation (a deletion of 3 bp was only analyzed by polyacrylamide gel electrophoresis and stained with AgNO3. Each sample was analyzed for regions of interest in the CFTR gene using amplified by PCR and specific primers. The deltaF508 and G551D mutations presented frequencies of 22.7 and 3%, respectively. In 74.3% of the remaining patients, none of the mutations investigated was found. The present study characterized in a sample of patients with an established clinical diagnosis of CF (asthma, repeated bronchopneumonia, disorders of nutritional status, etc. the most frequent mutation ( deltaF508 in the North region of Brazil and is also the first report of the G551D mutation. In spite of the wide spectrum of CF mutations and the heterogeneous ethnic origin of the Amazon population, the molecular diagnosis is a helpful additional tool for the diagnosis and treatment of CF patients.

[Pseudo-Bartter syndrome as manifestation of cystic fibrosis with DF508 mutation].

Science.gov (United States)

Galaviz-Ballesteros, María de Jesús; Acosta-Rodríguez-Bueno, Carlos Patricio; Consuelo-Sánchez, Alejandra; Franco-Álvarez, Isidro; Olalla-Mora, Odilo Iván; Vázquez-Frias, Rodrigo

Pseudo Bartter syndrome (PBS) is defined as hypokalaemic hypochloraemic metabolic alkalosis in the absence of renal tubular pathology. Children with cystic fibrosis (CF) are at risk of developing electrolyte abnormalities and even PBS may occur. 5 months old female infant with a history of two events of dehydration with vomit, refusal to eat, chronic cough, polyuria, malnutrition, metabolic alkalosis, hypokalemia, hyponatremia, hypochloremia and acute renal failure. Chronic cough study was performed, discarding pulmonary tuberculosis, gastroesophageal reflux disease and impaired swallowing. PBS was diagnosed due to hypokalaemic hypochloraemic metabolic alkalosis in the absence of renal tubular pathology. CF was corroborated by electrolytes in sweat and through molecular analysis of the delta F508 mutation. This is one of the few reported cases linking PBS and this mutation. In patients with hyponatremic dehydration episodes with hypokalaemic hypochloraemic metabolic alkalosis, PBS should be considered as differential diagnosis. CF could be presented as PBS, mainly in patients younger than 2 years. Copyright © 2016 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

Application of Bimodal Master Curve Approach on KSNP RPV steel SA508 Gr. 3

International Nuclear Information System (INIS)

Kim, Jongmin; Kim, Minchul; Choi, Kwonjae; Lee, Bongsang

2014-01-01

In this paper, the standard MC approach and BMC are applied to the forging material of the KSNP RPV steel SA508 Gr. 3. A series of fracture toughness tests were conducted in the DBTT transition region, and fracture toughness specimens were extracted from four regions, i.e., the surface, 1/8T, 1/4T and 1/2T. Deterministic material inhomogeneity was reviewed through a conventional MC approach and the random inhomogeneity was evaluated by BMC. In the present paper, four regions, surface, 1/8T, 1/4T and 1/2T, were considered for the fracture toughness specimens of KSNP (Korean Standard Nuclear Plant) SA508 Gr. 3 steel to provide deterministic material inhomogeneity and review the applicability of BMC. T0 determined by a conventional MC has a low value owing to the higher quenching rate at the surface as expected. However, more than about 15% of the KJC values lay above the 95% probability curves indexed with the standard MC T0 at the surface and 1/8T, which implies the existence of inhomogeneity in the material. To review the applicability of the BMC method, the deterministic inhomogeneity owing to the extraction location and quenching rate is treated as random inhomogeneity. Although the lower bound and upper bound curve of the BMC covered more KJC values than that of the conventional MC, there is no significant relationship between the BMC analysis lines and measured KJC values in the higher toughness distribution, and BMC and MC provide almost the same T0 values. Therefore, the standard MC evaluation method for this material is appropriate even though the standard MC has a narrow upper/lower bound curve range from the RPV evaluation point of view. The material is not homogeneous in reality. Such inhomogeneity comes in the effect of material inhomogeneity depending on the specimen location, heat treatment, and whole manufacturing process. The conventional master curve has a limitation to be applied to a large scatted data of fracture toughness such as the weld region