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Sample records for acne vulgaris

  1. Acne (Acne Vulgaris)

    Science.gov (United States)

    ... rash and rashes clinical tools newsletter | contact Share | Acne (Acne Vulgaris) Information for adults A A A Whiteheads (closed comedones) are the earliest lesions of acne. Overview Acne, also known as acne vulgaris, is ...

  2. Acne vulgaris.

    Science.gov (United States)

    Moradi Tuchayi, Sara; Makrantonaki, Evgenia; Ganceviciene, Ruta; Dessinioti, Clio; Feldman, Steven R; Zouboulis, Christos C

    2015-01-01

    Acne vulgaris is a chronic inflammatory disease - rather than a natural part of the life cycle as colloquially viewed - of the pilosebaceous unit (comprising the hair follicle, hair shaft and sebaceous gland) and is among the most common dermatological conditions worldwide. Some of the key mechanisms involved in the development of acne include disturbed sebaceous gland activity associated with hyperseborrhoea (that is, increased sebum production) and alterations in sebum fatty acid composition, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinization, induction of inflammation and dysfunction of the innate and adaptive immunity. Grading of acne involves lesion counting and photographic methods. However, there is a lack of consensus on the exact grading criteria, which hampers the conduction and comparison of randomized controlled clinical trials evaluating treatments. Prevention of acne relies on the successful management of modifiable risk factors, such as underlying systemic diseases and lifestyle factors. Several treatments are available, but guidelines suffer from a lack of data to make evidence-based recommendations. In addition, the complex combination treatment regimens required to target different aspects of acne pathophysiology lead to poor adherence, which undermines treatment success. Acne commonly causes scarring and reduces the quality of life of patients. New treatment options with a shift towards targeting the early processes involved in acne development instead of suppressing the effects of end products will enhance our ability to improve the outcomes for patients with acne. PMID:27189872

  3. Acne vulgaris.

    Science.gov (United States)

    Moradi Tuchayi, Sara; Makrantonaki, Evgenia; Ganceviciene, Ruta; Dessinioti, Clio; Feldman, Steven R; Zouboulis, Christos C

    2015-09-17

    Acne vulgaris is a chronic inflammatory disease - rather than a natural part of the life cycle as colloquially viewed - of the pilosebaceous unit (comprising the hair follicle, hair shaft and sebaceous gland) and is among the most common dermatological conditions worldwide. Some of the key mechanisms involved in the development of acne include disturbed sebaceous gland activity associated with hyperseborrhoea (that is, increased sebum production) and alterations in sebum fatty acid composition, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinization, induction of inflammation and dysfunction of the innate and adaptive immunity. Grading of acne involves lesion counting and photographic methods. However, there is a lack of consensus on the exact grading criteria, which hampers the conduction and comparison of randomized controlled clinical trials evaluating treatments. Prevention of acne relies on the successful management of modifiable risk factors, such as underlying systemic diseases and lifestyle factors. Several treatments are available, but guidelines suffer from a lack of data to make evidence-based recommendations. In addition, the complex combination treatment regimens required to target different aspects of acne pathophysiology lead to poor adherence, which undermines treatment success. Acne commonly causes scarring and reduces the quality of life of patients. New treatment options with a shift towards targeting the early processes involved in acne development instead of suppressing the effects of end products will enhance our ability to improve the outcomes for patients with acne.

  4. Acne vulgaris.

    Science.gov (United States)

    Williams, Hywel C; Dellavalle, Robert P; Garner, Sarah

    2012-01-28

    Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Although early colonisation with P acnes and family history might have important roles in the disease, exactly what triggers acne and how treatment affects the course of the disease remain unclear. Other factors such as diet have been implicated, but not proven. Facial scarring due to acne affects up to 20% of teenagers. Acne can persist into adulthood, with detrimental effects on self-esteem. There is no ideal treatment for acne, although a suitable regimen for reducing lesions can be found for most patients. Good quality evidence on comparative effectiveness of common topical and systemic acne therapies is scarce. Topical therapies including benzoyl peroxide, retinoids, and antibiotics when used in combination usually improve control of mild to moderate acne. Treatment with combined oral contraceptives can help women with acne. Patients with more severe inflammatory acne usually need oral antibiotics combined with topical benzoyl peroxide to decrease antibiotic-resistant organisms. Oral isotretinoin is the most effective therapy and is used early in severe disease, although its use is limited by teratogenicity and other side-effects. Availability, adverse effects, and cost, limit the use of photodynamic therapy. New research is needed into the therapeutic comparative effectiveness and safety of the many products available, and to better understand the natural history, subtypes, and triggers of acne. PMID:21880356

  5. [Acne vulgaris: endocrine aspects].

    Science.gov (United States)

    Dekkers, O M; Thio, B H; Romijn, J A; Smit, J W A

    2006-06-10

    Androgens play an important part in the development of acne vulgaris. Androgen levels in patients with acne are higher than those in controls and people with the androgen insensitivity syndrome do not develop acne. Local factors other than androgen plasma levels, also play a part in the development of acne. The skin contains enzymes that convert precursor hormones to the more potent androgens such as testosterone and dihydrotestosterone. Androgen synthesis can therefore be regulated locally. The effects of androgens on the skin are the result of circulating androgens and enzyme activity in local tissues and androgen receptors. Acne is a clinical manifestation of some endocrine diseases. The polycystic ovary syndrome has the highest prevalence. In women with acne that persists after puberty, in 10-200% of cases polycystic ovary syndrome is later diagnosed. The mechanism of hormonal anti-acne therapy may work by blocking the androgen-production (oestrogens) or by blocking the androgen receptor (cyproterone, spironolactone). PMID:16821451

  6. Sunflower Seed and Acne Vulgaris

    OpenAIRE

    Mohebbipour, Alireza; Sadeghi-Bazargani, Homayoun; Mansouri, Mona

    2015-01-01

    Background: Regardless of the overall association between diet and acne which cannot be easily ignored, there might be an association between specific nutrients and acne development or improvement. Objectives: The aim of this study was to assess the effect of dietary intake of sunflower seeds on acne severity and the pattern of acne lesions. Patients and Methods: In a randomized controlled trial, 50 patients aged 15 - 30 years old with acne vulgaris were enrolled through consecutive convenien...

  7. Propionibacterium acnes in the pathogenesis and immunotherapy of acne vulgaris.

    Science.gov (United States)

    Liu, Pei-Feng; Hsieh, Yao-Dung; Lin, Ya-Ching; Two, Aimee; Shu, Chih-Wen; Huang, Chun-Ming

    2015-01-01

    Acne vulgaris, a multi-factorial disease, is one of the most common skin diseases, affecting an estimated 80% of Americans at some point during their lives. The gram-positive and anaerobic Propionibacterium acnes (P. acnes) bacterium has been implicated in acne inflammation and pathogenesis. Therapies for acne vulgaris using antibiotics generally lack bacterial specificity, promote the generation of antibiotic-resistant bacterial strains, and cause adverse effects. Immunotherapy against P. acnes or its antigens (sialidase and CAMP factor) has been demonstrated to be effective in mice, attenuating P. acnes-induced inflammation; thus, this method may be applied to develop a potential vaccine targeting P. acnes for acne vulgaris treatment. This review summarizes reports describing the role of P. acnes in the pathogenesis of acne and various immunotherapy-based approaches targeting P. acnes, suggesting the potential effectiveness of immunotherapy for acne vulgaris as well as P. acnes-associated diseases.

  8. Management strategies for acne vulgaris

    Directory of Open Access Journals (Sweden)

    Whitney KM

    2011-04-01

    Full Text Available Kristen M Whitney1, Chérie M Ditre21Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA; 2Skin Enhancement Center and Cosmetic Dermatology, Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USADate of preparation: 30th November 2010Conflicts of interest: None declaredClinical question: What are the most effective treatment(s for mild, moderate, severe, and hormonally driven acne?Results: Mild acne responds favorably to topical treatments such as benzoyl peroxide, salicylic acid, and a low-dose retinoid. Moderate acne responds well to combination therapy comprising-topical benzoyl peroxide, antibiotics, and/or retinoids, as well as oral antibiotics in refractory cases and oral contraceptive pills for female acne patients. Severe nodulocystic acne vulgaris responds best to oral isotretinoin therapy. In female patients with moderate to severe acne, facial hair, loss of scalp hair and irregular periods, polycystic ovarian syndrome should be considered and appropriate treatment with hormonal modulation given. Adjunctive procedures can also be considered for all acne patients.Implementation: Pitfalls to avoid when treating acne: treatment of acne in women of childbearing age; familiarization of all acne treatments in order to individualize management for patients; indications for specialist referral.Keywords: acne vulgaris, benzoyl peroxide, retinoids, antibiotics, light and laser therapy, photodynamic therapy, photopneumatic therapy, chemical peels

  9. Epidemiology of acne vulgaris.

    Science.gov (United States)

    Bhate, K; Williams, H C

    2013-03-01

    Despite acne being an almost universal condition in younger people, relatively little is known about its epidemiology. We sought to review what is known about the distribution and causes of acne by conducting a systematic review of relevant epidemiological studies. We searched Medline and Embase to the end of November 2011. The role of Propionibacterium acnes in pathogenesis is unclear: antibiotics have a direct antimicrobial as well as an anti-inflammatory effect. Moderate-to-severe acne affects around 20% of young people and severity correlates with pubertal maturity. Acne may be presenting at a younger age because of earlier puberty. It is unclear if ethnicity is truly associated with acne. Black individuals are more prone to postinflammatory hyperpigmentation and specific subtypes such as 'pomade acne'. Acne persists into the 20s and 30s in around 64% and 43% of individuals, respectively. The heritability of acne is almost 80% in first-degree relatives. Acne occurs earlier and is more severe in those with a positive family history. Suicidal ideation is more common in those with severe compared with mild acne. In the U.S.A., the cost of acne is over 3 billion dollars per year in terms of treatment and loss of productivity. A systematic review in 2005 found no clear evidence of dietary components increasing acne risk. One small randomized controlled trial showed that low glycaemic index (GI) diets can lower acne severity. A possible association between dairy food intake and acne requires closer scrutiny. Natural sunlight or poor hygiene are not associated. The association between smoking and acne is probably due to confounding. Validated core outcomes in future studies will help in combining future evidence. PMID:23210645

  10. Epidemiology of acne vulgaris.

    Science.gov (United States)

    Bhate, K; Williams, H C

    2013-03-01

    Despite acne being an almost universal condition in younger people, relatively little is known about its epidemiology. We sought to review what is known about the distribution and causes of acne by conducting a systematic review of relevant epidemiological studies. We searched Medline and Embase to the end of November 2011. The role of Propionibacterium acnes in pathogenesis is unclear: antibiotics have a direct antimicrobial as well as an anti-inflammatory effect. Moderate-to-severe acne affects around 20% of young people and severity correlates with pubertal maturity. Acne may be presenting at a younger age because of earlier puberty. It is unclear if ethnicity is truly associated with acne. Black individuals are more prone to postinflammatory hyperpigmentation and specific subtypes such as 'pomade acne'. Acne persists into the 20s and 30s in around 64% and 43% of individuals, respectively. The heritability of acne is almost 80% in first-degree relatives. Acne occurs earlier and is more severe in those with a positive family history. Suicidal ideation is more common in those with severe compared with mild acne. In the U.S.A., the cost of acne is over 3 billion dollars per year in terms of treatment and loss of productivity. A systematic review in 2005 found no clear evidence of dietary components increasing acne risk. One small randomized controlled trial showed that low glycaemic index (GI) diets can lower acne severity. A possible association between dairy food intake and acne requires closer scrutiny. Natural sunlight or poor hygiene are not associated. The association between smoking and acne is probably due to confounding. Validated core outcomes in future studies will help in combining future evidence.

  11. Laser Treatment of Acne Vulgaris

    OpenAIRE

    Jih, Ming H.; Kimyai-Asadi, Arash

    2007-01-01

    Traditional medical treatments for acne vulgaris include a variety of topical and oral medications. The combination of poor compliance, lack of durable remission, and potential side effects are common drawbacks to these treatments. The use of lasers and light devices has increased dramatically in recent years due to the overall ease of treatment, predictable clinical efficacy, and minimal adverse effects. A variety of light and laser devices has been used for the treatment of acne, including ...

  12. The Historic Panorama of Acne Vulgaris

    OpenAIRE

    Humyra Tabasum; Tanzeel Ahmad; Farzana Anjum; Hina Rehman

    2013-01-01

    Although acne is described in very ancient writings dating back to Eber’s Papyrus, its clear description is found after Fuch’s coined the term ‘Acne Vulgaris’ and Erasmus Wilson separated it from acne rosacea. The early treatment of acne was based upon the witchcraft. Later new therapies got evolved with the discoveries in the field of anatomy, physiology and biochemistry. The following review focuses the historical overview of acne vulgaris, highlighting persons and discoveries in medival an...

  13. The psychosocial impact of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Neirita Hazarika

    2016-01-01

    Full Text Available Background: Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period. Aims: To assess the impact of acne on the various psychosocial domains of daily life. Materials and Methods: This was a prospective, cross-sectional study done in the dermatology out-patient department of a tertiary care hospital from January to March 2015. A total of 100 consecutive, newly diagnosed patients of acne vulgaris, aged 15 years and above were included in this study. The relationship between acne vulgaris and its sequelae was analyzed with ten different domains of daily life by using dermatology life quality index (DLQI questionnaire. Results: Females (56%, 15–20 year olds (61%, facial lesions (60%, and Grade II acne (70% were most common. Acne scars were noted in 75% patients, whereas 79% cases had post-acne hyperpigmentation. Thirty-seven percent patients had DLQI scores of (6–10 interpreted as moderate effect on patient's life. Statistically significant correlation (P < 0.05 found were as follows: Physical symptoms with grade of acne; embarrassment with site and grade of acne; daily activities with grade of acne and post-acne pigmentation; choice of clothes with site of acne; social activities with gender, site and grade of acne; effect on work/study with grade of acne; interpersonal problems with site and post-acne pigmentation; sexual difficulties with grade of acne. Limitation: It was a hospital-based study with small sample size. Conclusion: Significant impact of acne and its sequelae was noted on emotions, daily activities, social activities, study/work, and interpersonal relationships. Assurance and counseling along with early treatment of acne vulgaris is important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment.

  14. Oxidative Stress in Patients With Acne Vulgaris

    OpenAIRE

    2005-01-01

    Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aim to determine the effects of oxidative stress in acne vulgaris. Forty-three consecutive acne patients and 46 controls were enrolled. The parameters of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood of cases were measured spectrophotometrically. The values compared wi...

  15. Insulin resistance in severe acne vulgaris

    OpenAIRE

    Emiroğlu, Nazan; Cengiz, Fatma Pelin; Kemeriz, Funda

    2015-01-01

    Introduction Acne vulgaris is a pilosebaceous gland disease that usually affects people from puberty to young adulthood. It is seen especially on the face, neck, trunk and arms. Its severity differs from patient to patient and its pathogenesis is multifactorial. The main pathogenic factors of acne are high sebaceous gland secretion, follicular hyperproliferation, high androgen effects, propionibacterium acnes colonization and inflammation. Diet is always thought a probable reason for acne and...

  16. Acne Vulgaris and Acne Rosacea: An Update in Etiopathogenesis

    Directory of Open Access Journals (Sweden)

    Ozlem Ekiz

    2014-04-01

    Full Text Available Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, characterized by comedones, papules, pustules, nodules, and scars rarely. The major pathogenic factors are abnormal follicular differentiation and increased ductal cornification, abnormal activity of sebaceous glands, microbial colonization of pilosebaceous units by Propionibacterium acnes and inflammation. Rosacea is a common, chronic inflammatory relapsing skin disorder of the central area of the face characterized by transient or persistent erythema, telangiectasia, papules and pustules. Although several hypotheses have been suggested for the etiopathogenesis of rosacea, the exact etiology is still unknown. In this review, we tried to summarize up-to-date information about etiopathogenesis of acne vulgaris and rosocea.

  17. The Historic Panorama of Acne Vulgaris

    Directory of Open Access Journals (Sweden)

    Humyra Tabasum

    2013-09-01

    Full Text Available Although acne is described in very ancient writings dating back to Eber’s Papyrus, its clear description is found after Fuch’s coined the term ‘Acne Vulgaris’ and Erasmus Wilson separated it from acne rosacea. The early treatment of acne was based upon the witchcraft. Later new therapies got evolved with the discoveries in the field of anatomy, physiology and biochemistry. The following review focuses the historical overview of acne vulgaris, highlighting persons and discoveries in medival and modern period.

  18. Pulse Clarithromycin Therapy In Severe ACNE Vulgaris

    Directory of Open Access Journals (Sweden)

    Rathi Sanjay K

    2002-01-01

    Full Text Available Three patients with severe acne vulgaris, not responding with long courses of doxycycline, minocycline and erythromycin were given oral clarithromycin in pulsed regimen. The patients were given 7 days course of clarithromycin 250mg twice daily, which was repeated after a gap of 10 days. Such 3 courses were given. The lesions responded significantly. No significant side effect was noted. Pulse clarithromycin therapy seems to be a good alternative and effective tool in the management of severe acne vulgaris.

  19. Acne vulgaris and rosacea: evaluation and management.

    Science.gov (United States)

    Webster, G F

    2001-01-01

    Acne vulgaris, commonly termed acne, is an extremely common disease. It can be found in nearly all teenagers to some degree as well as in women in their 30s. Regardless of severity, acne often has a greater psychologic effect than cutaneous effect. Indeed, most patients overestimate the severity of their disease, while most physicians underestimate its impact on their patients. Studies have shown that people with severe acne as teens are less employable as adults and that self-esteem is low. When combined with other adolescent tensions, acne can be a difficult disease to treat. Rosacea, which usually starts in the late 20s, may affect the eyes as well as the skin. This article describes the pathogenesis of acne and rosacea and treatment approaches the primary care physician can use. PMID:12739318

  20. ACNE VULGARIS TREATMENT : THE CURRENT SCENARIO

    OpenAIRE

    Rathi, Sanjay K

    2011-01-01

    Acne Vulgaris is one of the most common skin disorders which dermatologists have to treat. It mainly affect adolescent, though may present at any age. In recent years, due to better understanding of the pathogenesis of acne, new therapeutic modalities and various permutation and combinations have been designed. In topical agents; benzoyl peroxide, antibiotics, retinoids, etc are the mainstay of treatment; can be given in combinations. While systemic therapy includes oral antibiotics, hormonal...

  1. Treatment of acne vulgaris with anti androgens

    OpenAIRE

    Vaswani Neena; Pandhi R

    1990-01-01

    This study was conducted to compare the relative efficacy of spironolactone and cimetidine in moderately severe acne vulgaris. Fifteen women were treated with spironolactone (100 mg daily) given cyclically, while 14 women were given cimetidine (1400 mg daily) cyclically. The response was evaluated at 12 weeks. Spironolactone produced a good to excellent response in 11 (73. 3%) acne patients while with cimetidine 6 (42.8%) patients showed a good to excellent response. The mean re...

  2. The psychosocial impact of acne vulgaris

    OpenAIRE

    Neirita Hazarika; M Archana

    2016-01-01

    Background: Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period. Aims: To assess the impact of acne on the various psychosocial domains of daily life. Materials and Methods: This was a prospective, cross-sectional study done in the dermatology out-patient department of a tertiary care hospital from January...

  3. [ACNE VULGARIS--AETIOLOGY, CLASSIFICATION, TREATMENT].

    Science.gov (United States)

    Janda, Katarzyna; Chwilkowska, Magdalena

    2014-01-01

    A spotless skin is a rarity. Both women and men have different problems related to the complexion. One of the most common problems is acne, which affects an increasing number of people of all ages. Seborrhea skin areas rich in sebaceous glands, the formation of comedones, inflammation, and scars are characteristic for this disease. The aim of the study was to discuss the causes of acne vulgaris, methods of treatment, and proper care of the skin affected by this problem.

  4. Hormonal treatment of acne vulgaris: an update.

    Science.gov (United States)

    Elsaie, Mohamed L

    2016-01-01

    Acne vulgaris is a common skin condition associated with multiple factors. Although mostly presenting alone, it can likewise present with features of hyperandrogenism and hormonal discrepancies. Of note, hormonal therapies are indicated in severe, resistant-to-treatment cases and in those with monthly flare-ups and when standard therapeutic options are inappropriate. This article serves as an update to hormonal pathogenesis of acne, discusses the basics of endocrinal evaluation for patients with suspected hormonal acne, and provides an overview of the current hormonal treatment options in women. PMID:27621661

  5. Hormonal treatment of acne vulgaris: an update

    Science.gov (United States)

    Elsaie, Mohamed L

    2016-01-01

    Acne vulgaris is a common skin condition associated with multiple factors. Although mostly presenting alone, it can likewise present with features of hyperandrogenism and hormonal discrepancies. Of note, hormonal therapies are indicated in severe, resistant-to-treatment cases and in those with monthly flare-ups and when standard therapeutic options are inappropriate. This article serves as an update to hormonal pathogenesis of acne, discusses the basics of endocrinal evaluation for patients with suspected hormonal acne, and provides an overview of the current hormonal treatment options in women. PMID:27621661

  6. Treatment of acne vulgaris with anti androgens

    Directory of Open Access Journals (Sweden)

    Vaswani Neena

    1990-01-01

    Full Text Available This study was conducted to compare the relative efficacy of spironolactone and cimetidine in moderately severe acne vulgaris. Fifteen women were treated with spironolactone (100 mg daily given cyclically, while 14 women were given cimetidine (1400 mg daily cyclically. The response was evaluated at 12 weeks. Spironolactone produced a good to excellent response in 11 (73. 3% acne patients while with cimetidine 6 (42.8% patients showed a good to excellent response. The mean reduction of the non-inflammatory and inflammatory lesion count was 29. 3 + 3. 6 and 9. 7 + 1. 3 respectively with spironolactone and 18.6 + 5.8 and 6.4 + 2.1 respectively with cimetidine. The response of acne vulgaris to spironolactone was superior to that of cimetidine and this difference was statistically significant (p< .05. The side effects were minimal and did not necessitate withdrawal of treatment.

  7. Significance of diet in treated and untreated acne vulgaris

    OpenAIRE

    Kucharska, Alicja; Szmurło, Agnieszka; Sińska, Beata

    2016-01-01

    The relationship between diet and acne is highly controversial. Several studies during the last decade have led dermatologists to reflect on a potential link between diet and acne. This article presents the latest findings on a potential impact that diet can have on pathogenesis of acne vulgaris. The association between diet and acne can no longer be dismissed. Compelling evidence shows that high glycemic load diets may exacerbate acne. Dairy ingestion appears to be weakly associated with acn...

  8. Management strategies for acne vulgaris

    OpenAIRE

    Ditre, Cherie

    2011-01-01

    Kristen M Whitney1, Chérie M Ditre21Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA; 2Skin Enhancement Center and Cosmetic Dermatology, Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USADate of preparation: 30th November 2010Conflicts of interest: None declaredClinical question: What are the most effective treatment(s) for mild, moderate, severe, and hormonally driven acne?Results: Mild acne responds favorably to topi...

  9. Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

    OpenAIRE

    Majid Rostami Mogaddam; Nastaran Safavi Ardabili; Nasrollah Maleki; Maedeh Soflaee

    2014-01-01

    Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry ...

  10. Impaired water barrier function in acne vulgaris.

    Science.gov (United States)

    Yamamoto, A; Takenouchi, K; Ito, M

    1995-01-01

    In acne vulgaris, abnormal follicular keratinization is important for comedo formation, yet the precise mechanisms of comedogenesis are not known. The present study examined the interrelationship between sebum secretion rate (SSR), lipid content and water barrier function (WBF) of the stratum corneum (SC) in 36 acne patients and 29 control subjects. All major SC lipid classes were separated and quantified by thin-layer chromatography/photodensitometry. WBF was evaluated by measuring transepidermal water loss (TEWL), and the hygroscopic properties and waterholding capacity of the SC. The SSR over a period of 3 h was significantly higher in patients with moderate acne than in control subjects, but no significant difference was noticed between patients with mild acne and control subjects. Significant differences between patients with both moderate and mild acne and control subjects were noted in the amount of sphingolipids (ceramides and free sphingosine), but not for any other lipid classes. Furthermore in acne patients, lower amounts of sphingolipids were observed corresponding with a diminished WBF. These results suggest that an impaired WBF caused by decreased amounts of ceramides may be responsible for comedo formation, since barrier dysfunction is accompanied by hyperkeratosis of the follicular epithelium.

  11. Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris.

    Directory of Open Access Journals (Sweden)

    Teruaki Nakatsuji

    Full Text Available BACKGROUND: Acne vulgaris afflicts more than fifty million people in the United State and the severity of this disorder is associated with the immune response to Propionibacterium acnes (P. acnes. Systemic therapies for acne target P. acnes using antibiotics, or target the follicle with retinoids such as isotretinoin. The latter systemic treatment is highly effective but also carries a risk of side effects including immune imbalance, hyperlipidemia, and teratogenicity. Despite substantial research into potential new therapies for this common disease, vaccines against acne vulgaris are not yet available. METHODS AND FINDINGS: Here we create an acne vaccine targeting a cell wall-anchored sialidase of P. acnes. The importance of sialidase to disease pathogenesis is shown by treatment of a human sebocyte cell line with recombinant sialidase that increased susceptibility to P. acnes cytotoxicity and adhesion. Mice immunized with sialidase elicit a detectable antibody; the anti-sialidase serum effectively neutralized the cytotoxicity of P. acnes in vitro and P. acnes-induced interleukin-8 (IL-8 production in human sebocytes. Furthermore, the sialidase-immunized mice provided protective immunity against P. acnes in vivo as this treatment blocked an increase in ear thickness and release of pro-inflammatory macrophage inflammatory protein (MIP-2 cytokine. CONCLUSIONS: Results indicated that acne vaccines open novel therapeutic avenues for acne vulgaris and other P. acnes-associated diseases.

  12. Topical and oral antibiotics for acne vulgaris.

    Science.gov (United States)

    Del Rosso, James Q

    2016-06-01

    Antibiotics, both oral and topical, have been an integral component of the management of acne vulgaris (AV) for approximately 6 decades. Originally thought to be effective for AV due to their ability to inhibit proliferation of Propionibacterium acnes, it is now believed that at least some antibiotics also exert anti-inflammatory effects that provide additional therapeutic benefit. To add, an increase in strains of P acnes and other exposed bacteria that are less sensitive to antibiotics used to treat AV have emerged, with resistance directly correlated geographically with the magnitude of antibiotic use. Although antibiotics still remain part of the therapeutic armamentarium for AV treatment, current recommendations support the following when used to treat AV: 1) monotherapy use should be avoided; 2) use benzoyl peroxide concomitantly to reduce emergence of resistant P acnes strains; 3) oral antibiotics should be used in combination with a topical regimen for moderate-to-severe inflammatory AV; and 4) use oral antibiotics over a limited duration to achieve control of inflammatory AV with an exit plan in place to discontinue their use as soon as possible. When selecting an oral antibiotic to treat AV, potential adverse effects are important to consider. PMID:27416309

  13. Topical and oral antibiotics for acne vulgaris.

    Science.gov (United States)

    Del Rosso, James Q

    2016-06-01

    Antibiotics, both oral and topical, have been an integral component of the management of acne vulgaris (AV) for approximately 6 decades. Originally thought to be effective for AV due to their ability to inhibit proliferation of Propionibacterium acnes, it is now believed that at least some antibiotics also exert anti-inflammatory effects that provide additional therapeutic benefit. To add, an increase in strains of P acnes and other exposed bacteria that are less sensitive to antibiotics used to treat AV have emerged, with resistance directly correlated geographically with the magnitude of antibiotic use. Although antibiotics still remain part of the therapeutic armamentarium for AV treatment, current recommendations support the following when used to treat AV: 1) monotherapy use should be avoided; 2) use benzoyl peroxide concomitantly to reduce emergence of resistant P acnes strains; 3) oral antibiotics should be used in combination with a topical regimen for moderate-to-severe inflammatory AV; and 4) use oral antibiotics over a limited duration to achieve control of inflammatory AV with an exit plan in place to discontinue their use as soon as possible. When selecting an oral antibiotic to treat AV, potential adverse effects are important to consider.

  14. ICG laser therapy of acne vulgaris

    Science.gov (United States)

    Tuchin, Valery V.; Altshuler, Gregory B.; Genina, Elina A.; Bashkatov, Alexey N.; Simonenko, Georgy V.; Odoevskaya, Olga D.; Yaroslavsky, Ilya V.

    2004-07-01

    The near-infrared (NIR) laser radiation due to its high penetration depth is widely used in phototherapy. In application to skin appendages a high selectivity of laser treatment is needed to prevent light action on surrounding tissues. Indocyanine Green (ICG) dye may provide a high selectivity of treatment due to effective ICG uploading by a target and its narrow band of considerable absorption just at the wavelength of the NIR diode laser. The goal of this study is to demonstrate the efficacy of the NIR diode laser phototherapy in combination with topical application of ICG suggested for soft and thermal treatment of acne vulgaris. 28 volunteers with facile or back-located acne were enrolled. Skin sites of subjects were stained by ICG and irradiated by NIR laser-diode light (803 or 809 nm). Untreated, only stained and only light irradiated skin areas served as controls. For soft acne treatment, the low-intensity (803 nm, 10 - 50 mW/cm2, 5-10 min) or the medium-intensity (809 nm, 150 - 190 mW/cm2, 15 min) protocols were used. The single and multiple (up to 8-9) treatments were provided. The individual acne lesions were photothermally treated at 18 W/cm2 (803 nm, 0.5 sec) without skin surface cooling or at 200 W/cm2 (809 nm, 0.5 sec) with cooling. The results of the observations during 1-2 months after the completion of the treatment have shown that only in the case of the multiple-wise treatment a combined action of ICG and NIR irradiation reduces inflammation and improves skin state during a month without any side effects. At high power densities (up to 200 W/cm2) ICG stained acne inflammatory elements were destructed for light exposures of 0.5 sec. Based on the concept that hair follicle, especially sebaceous gland, can be intensively and selectively stained by ICG due to dye diffusion through pilosebaceous canal and its fast uptake by living microorganisms, by vital keratinocytes of epithelium of the canal and sebaceous duct, and by rapidly proliferating

  15. Significance of diet in treated and untreated acne vulgaris.

    Science.gov (United States)

    Kucharska, Alicja; Szmurło, Agnieszka; Sińska, Beata

    2016-04-01

    The relationship between diet and acne is highly controversial. Several studies during the last decade have led dermatologists to reflect on a potential link between diet and acne. This article presents the latest findings on a potential impact that diet can have on pathogenesis of acne vulgaris. The association between diet and acne can no longer be dismissed. Compelling evidence shows that high glycemic load diets may exacerbate acne. Dairy ingestion appears to be weakly associated with acne and the roles of omega-3 fatty acids, dietary fiber, antioxidants, vitamin A, zinc and iodine remain to be elucidated. The question of what the impact of diet is on the course of acne vulgaris still remains unclear. PMID:27279815

  16. Significance of diet in treated and untreated acne vulgaris.

    Science.gov (United States)

    Kucharska, Alicja; Szmurło, Agnieszka; Sińska, Beata

    2016-04-01

    The relationship between diet and acne is highly controversial. Several studies during the last decade have led dermatologists to reflect on a potential link between diet and acne. This article presents the latest findings on a potential impact that diet can have on pathogenesis of acne vulgaris. The association between diet and acne can no longer be dismissed. Compelling evidence shows that high glycemic load diets may exacerbate acne. Dairy ingestion appears to be weakly associated with acne and the roles of omega-3 fatty acids, dietary fiber, antioxidants, vitamin A, zinc and iodine remain to be elucidated. The question of what the impact of diet is on the course of acne vulgaris still remains unclear.

  17. Calcinosis cutis secondary to facial acne vulgaris: A rare complication.

    Science.gov (United States)

    Sahu, Srimanta Kumar; Gupta, Nikhil; Vohra, Suruchi

    2015-12-01

    Acne vulgaris is a common dermatological disease commonly affecting the adolescent and young adults. It is characterized by the presence of pleomorphic skin lesions such as comadones, papules, pustules, and nodules. The common complications are postacne hyperpigmentation and scarring causing psychological impact. Calcinosis cutis is the pathologic deposition of insoluble calcium salt in the skin and subcutaneous tissue. Calcinosis cutis following acne vulgaris is rarely reported in the literature. We report a case of calcinosis cutis in acne vulgaris in a 55-year-old man.

  18. Acne vulgaris: A review of causes and treatment options.

    Science.gov (United States)

    Well, Danielle

    2013-10-10

    Acne vulgaris is a disorder of the sebaceous follicle. The cause is multifactorial, and both adolescents and adults can be affected. Acne is associated with a significant financial burden and considerable psychological distress. Treatment options are reviewed, including over-the-counter medications, prescription medications, and in-office procedures.

  19. Efficacy and Safety of Topical Niacinamide for Acne Vulgaris

    OpenAIRE

    Zeynep Nurhan Saraçoğlu; Ayşe Esra Koku Aksu; Tuğçe Köksüz; İlham Sabuncu; İnci Arıkan

    2011-01-01

    Background and Design: To investigate the efficacy and safety of topical 4% naicinamide gel cream in the treatment of mild to moderate acne vulgaris and to assess the quality of life of acne patients.Material and Method: Twenty-nine female patients aged 16-38 (mean: 23.57±5.42) years with mild to moderate acne vulgaris who presented in dermatology outpatient clinic were enrolled in the study. All patients applied 4% niacinamide gel cream (Vivatinell-acnecinamide gel cream®) on their faces twi...

  20. Acne vulgaris: diagnosis and management by the family physician

    Directory of Open Access Journals (Sweden)

    Ana Margarida Ferreira da Silva

    2014-01-01

    Full Text Available Acne vulgaris is the most common skin disease worldwide. It affects 85-100% of the population at any point in life. Consequently, it is a frequent reason for primary care visits. It usually begins at puberty, reaching its peak between the age of 14-17 in girls, and 16-19 in boys, and it is more severe and prevalent in males. Although widely discussed, Acne vulgaris still requires constant updating. We conducted a survey of clinical guidelines, systematic reviews, and meta-analyses published over the past 15 years, concerning acne vulgaris and its treatment. Acne vulgaris is usually divided in three clinical types: comedonal, papulopustular, and nodular. The diagnosis is based on clinical signs; however, other conditions should be considered. There are several pharmacological therapies available, especially retinoids, antimicrobials, and hormone therapy, which should be used after considering its indications (type of acne and its severity and side effects. Thus, the family physician plays a leading role in addressing acne vulgaris, from diagnosis to management of therapeutic options. 

  1. Knowledge, Beliefs, and Psychosocial Effect of Acne Vulgaris among Saudi Acne Patients

    OpenAIRE

    Magdy A Darwish; Al-Rubaya, Ahmed A.

    2013-01-01

    Objective. This study was conducted to assess the knowledge, beliefs, and psychosocial effect of acne vulgaris among acne patients attending referral dermatology clinic in Al-Khobar city. Material and Methods. A cross-sectional study was conducted on all Saudi acne patients (males and females) attending referral dermatology clinic in Al-Khobar Governmental Hospital. The data were collected by using a structured self-administered questionnaire. Results. Like other studies conducted before, we ...

  2. Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris

    OpenAIRE

    K. O. Abulnaja

    2009-01-01

    Acne vulgaris is a multifactorial disease affecting a majority of the adolescent population. The objective of this study was to test for a correlation between fasting serum lipid profiles and levels of testosterone, insulin, leptin, and interleukin 1-β (IL-1β) and the incidence of severe acne vulgaris in obese adolescent females. Four groups of adolescent females were studied: obese with acne, obese without acne, non-obese with acne, and non-obese without acne. Obese females with ac...

  3. An update on the management of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Jonette Keri

    2009-06-01

    Full Text Available Jonette Keri1,2, Michael Shiman11Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; 2Dermatology Service, Miami VA Hospital, FL, USAAbstract: Acne vulgaris is a common skin disorder that can affect individuals from childhood to adulthood, most often occurring in the teenage years. Acne can have a significant physical, emotional, and social impact on an individual. Many different treatment options are available for the treatment of acne vulgaris. Commonly used topical treatments include benzoyl peroxide, antibiotics, sulfur and sodium sulfacetamide, azelaic acid, and retinoids. Systemic treatment is frequently used and includes the use of systemic antibiotics, oral contraceptives, antiandrogens, and retinoids. Other treatment modalities exist such as the use of superficial chemical peels as well as using laser and light devices for the treatment of acne. With the multitude of treatment options and the rapidly expanding newer technologies available to clinicians, it is important to review and be aware of the current literature and studies regarding the treatment of acne vulgaris.Keywords: acne vulgaris, treatment, benzoyl peroxide, antibiotics, retinoids, lasers

  4. Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris.

    Science.gov (United States)

    Rostami Mogaddam, Majid; Safavi Ardabili, Nastaran; Maleki, Nasrollah; Soflaee, Maedeh

    2014-01-01

    Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P = 0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

  5. Acne, vulgaris on the back (image)

    Science.gov (United States)

    Acne frequently occurs on the back. Here, there are 2 to 6 millimeter wide erythematous (red) pustules ... Permanent scarring may follow a severe case of acne. Men are more often affected on their shoulders ...

  6. TRENDS OF SELF MEDICATION IN PATIENTS WITH ACNE VULGARIS

    OpenAIRE

    Tanzeela Khalid; Tariq Iqbal

    2010-01-01

    Back ground:Self medication is a norm in our country. One factor probably contributing to this phenomenonis over the counter sale of almost all medication without any regulation. In our dermatologypractice, we frequently encounter patients with acne vulgaris deteriorated by topical use of selfmedication. However, there is very little data to support this in our set up.Objective:To determine the percentage of acne patients using self medication in our population.Design:A cross-sectional survey...

  7. An update on the management of acne vulgaris

    OpenAIRE

    Shiman,

    2009-01-01

    Jonette Keri1,2, Michael Shiman11Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; 2Dermatology Service, Miami VA Hospital, FL, USAAbstract: Acne vulgaris is a common skin disorder that can affect individuals from childhood to adulthood, most often occurring in the teenage years. Acne can have a significant physical, emotional, and social impact on an individual. Many different treatment options are available for the treatment of a...

  8. Body Image Disturbance in Patients with Acne Vulgaris

    OpenAIRE

    Bowe, Whitney P; Doyle, Amanda K.; Crerand, Canice E.; Margolis, David J.; Shalita, Alan R.

    2011-01-01

    Psychosocial outcome measures, which attempt to examine acne from the patient's perspective, have become increasingly important in dermatology research. One such measure is the Body Image Disturbance Questionnaire. The authors' primary aim was to determine the validity and internal consistency of the Body Image Disturbance Questionnaire in patients with acne vulgaris. The secondary aim was to investigate the relationship between body image disturbance and quality of life. This cross-sectional...

  9. Use of tazarotene foam for the treatment of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Gregoriou S

    2014-05-01

    Full Text Available Stamatis Gregoriou, Eleftheria Kritsotaki, Alexandros Katoulis, Dimitris RigopoulosSecond Department of Dermatology and Venereology, Attikon Hospital, University of Athens Medical School, Athens, GreeceAbstract: Acne vulgaris is a common inflammatory chronic disease of the pilosebaceous unit. It often requires long-term treatment, resulting in increased demand for topical medications that are popular with patients in order to achieve long-term compliance. Tazarotene foam 1% is a novel formulation of tazarotene. We review efficacy and tolerability studies of the new formulation, and suggest a possible place for the product in the management of acne vulgaris.Keywords: retinoids, efficacy, safety, tolerability

  10. Treatment of acne vulgaris with fractional radiofrequency microneedling.

    Science.gov (United States)

    Kim, Sang Tae; Lee, Kang Hoon; Sim, Hyung Jun; Suh, Kee Suck; Jang, Min Soo

    2014-07-01

    Fractional radiofrequency microneedling is a novel radiofrequency technique that uses insulated microneedles to deliver energy to the deep dermis at the point of penetration without destruction of the epidermis. It has been used for the treatment of various dermatological conditions including wrinkles, atrophic scars and hypertrophic scars. There have been few studies evaluating the efficacy of fractional radiofrequency microneedling in the treatment of acne, and none measuring objective parameters like the number of inflammatory and non-inflammatory acne lesions or sebum excretion levels. The safety and efficacy of fractional radiofrequency microneedling in the treatment of acne vulgaris was investigated. In a prospective clinical trial, 25 patients with moderate to severe acne were treated with fractional radiofrequency microneedling. The procedure was carried out three times at 1-month intervals. Acne lesion count, subjective satisfaction score, sebum excretion level and adverse effects were assessed at baseline and at 4, 8 and 12 weeks after the first treatment as well as 4, 8 and 12 weeks after the last treatment. Number of acne lesions (inflammatory and non-inflammatory) decreased. Sebum excretion and subjective satisfaction were more favorable at every time point compared with the baseline values (P acne vulgaris.

  11. The epidemiology of acne vulgaris in late adolescence

    Directory of Open Access Journals (Sweden)

    Lynn DD

    2016-01-01

    Full Text Available Darren D Lynn,1 Tamara Umari,1 Cory A Dunnick,2,3 Robert P Dellavalle2–4 1Department of Dermatology, University of Colorado School of Medicine, 2Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, 3Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, 4Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Importance: Acne vulgaris is the most common skin condition affecting late adolescents across the globe. Although prior studies have evaluated epidemiologic patterns of acne vulgaris in various ethnicities and regions, adequate understanding of the worldwide burden of the disease associated with patients in their late adolescence (15–19-year olds remains lacking. Objective: To assess the global burden of the disease associated with acne vulgaris for late adolescents (15–19-year olds and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population. Design: Database summary study. Setting: Global Burden of Disease Study 2010 database. Participants: Global Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years. Main outcomes and measures: Geographic region-level disability-adjusted life year rates (per 100,000 persons associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability-adjusted life year rates was estimated for each region across the specified study period. Conclusion and relevance: Acne vulgaris-associated disease burden exhibits global distribution and has continued to grow in prevalence over time within this population. This continued growth suggests an unmet dermatologic need worldwide for this disorder and potential opportunities for improved access and delivery of dermatologic care. Our analysis of the literature reveals numerous

  12. Comparison of three different regimens of oral azithromycin in the treatment of acne vulgaris

    OpenAIRE

    Naieni Farahnaz; Akrami Hooman

    2006-01-01

    Background: Acne vulgaris is a common skin disease that involves pilosebaceous units. Oral antibiotics are the most widely administered drugs, which are prescribed as systemic therapy for treatment of moderate to severe acne vulgaris. Azithromycin is one of the antibiotics that has been recently used for acne treatment. There are several protocols of oral azithromycin in the treatment of acne. Objective: To compare three various regimens of oral azithromycin in the treatment of acne. Mate...

  13. Profile of acne vulgaris-A hospital-based study from South India

    Directory of Open Access Journals (Sweden)

    Adityan Balaji

    2009-01-01

    Full Text Available Background: Acne vulgaris is believed to be the most common disease of the skin. There is no Indian study on the profile of acne vulgaris, markers of severe forms of acne vulgaris and a possible correlation between acne vulgaris and markers of androgenicity in females. Aim: To study the profile of acne vulgaris, its seasonal variation, relationship with smoking and possible correlation between acne vulgaris and markers of androgenicity in females. Methods: The study was conducted between August 2006 and June 2008. All patients with acne vulgaris who consented to participate in the study were included. The parameters evaluated included age, gender, age of onset, duration of lesions, site of lesions, grade, relation with menstrual cycle, markers of androgenicity, number of acne lesions such as comedones, papules pustules and nodules, number and site of post-acne scarring, post-acne hyperpigmentation, seasonal variation and history of smoking. Results: A total of 309 patients with acne vulgaris were included in the study. The frequency of acne vulgaris in our study was 1.068%. Mean age of the study group was 19.78 years. Male to female ratio was 1.25:1. The most common age group involved was 16 to 20 years (59.8%. Mean age of onset was 15.97 years. Face was involved in all the patients, followed by back (28.2%, chest (20.1%, neck (9.4% and arms (10%. In the older age groups, women were more likely to report having acne vulgaris than men ( P = 0.01. The closed comedones outnumbered open comedones by a factor of 4.9:1. A total of 186 patients (60.2% had grade 1 acne vulgaris, 85 (27.5% had grade 2 acne, 8 (2.6% had grade 3 acne and 30 (9.7% had grade 4 acne vulgaris. There was a higher incidence of scarring (39.5% and post-acne hyperpigmentation (24.6% in our study. In female patients, 57.7% had premenstrual flare and 12.4% had cutaneous markers of androgenicity. There was no association between severity of acne vulgaris and other markers of

  14. Body Image Disturbance in Patients with Acne Vulgaris

    Science.gov (United States)

    Bowe, Whitney P.; Crerand, Canice E.; Margolis, David J.; Shalita, Alan R.

    2011-01-01

    Psychosocial outcome measures, which attempt to examine acne from the patient's perspective, have become increasingly important in dermatology research. One such measure is the Body Image Disturbance Questionnaire. The authors' primary aim was to determine the validity and internal consistency of the Body Image Disturbance Questionnaire in patients with acne vulgaris. The secondary aim was to investigate the relationship between body image disturbance and quality of life. This cross-sectional investigation included 52 consecutive acne patients presenting to an outpatient dermatology clinic. Subjects completed the Body Image Disturbance Questionnaire, Skindex-16, and other body image and psychosocial functioning measures. An objective assessment of acne was performed. The Body Image Disturbance Questionnaire was internally consistent and converged with other known body image indices. Body Image Disturbance Questionnaire scores also correlated with Skindex-16 scores, confirming that quality of life and body image are related psychosocial constructs. The Body Image Disturbance Questionnaire appears to be an accurate instrument that can assess appearance-related concern and impairment in patients with acne vulgaris. Limitations include a small sample size and the cross-sectional design. PMID:21779418

  15. Body image disturbance in patients with acne vulgaris.

    Science.gov (United States)

    Bowe, Whitney P; Doyle, Amanda K; Crerand, Canice E; Margolis, David J; Shalita, Alan R

    2011-07-01

    Psychosocial outcome measures, which attempt to examine acne from the patient's perspective, have become increasingly important in dermatology research. One such measure is the Body Image Disturbance Questionnaire. The authors' primary aim was to determine the validity and internal consistency of the Body Image Disturbance Questionnaire in patients with acne vulgaris. The secondary aim was to investigate the relationship between body image disturbance and quality of life. This cross-sectional investigation included 52 consecutive acne patients presenting to an outpatient dermatology clinic. Subjects completed the Body Image Disturbance Questionnaire, Skindex-16, and other body image and psychosocial functioning measures. An objective assessment of acne was performed. The Body Image Disturbance Questionnaire was internally consistent and converged with other known body image indices. Body Image Disturbance Questionnaire scores also correlated with Skindex-16 scores, confirming that quality of life and body image are related psychosocial constructs. The Body Image Disturbance Questionnaire appears to be an accurate instrument that can assess appearance-related concern and impairment in patients with acne vulgaris. Limitations include a small sample size and the cross-sectional design. PMID:21779418

  16. Passive Immunoprotection Targeting a Secreted CAMP Factor of Propionibacterium acnes as a Novel Immunotherapeutic for Acne Vulgaris

    OpenAIRE

    Liu, Pei-Feng; Nakatsuji, Teruaki; Zhu, Wenhong; Gallo, Richard L; Huang, Chun-Ming

    2011-01-01

    Propionibacterium acnes (P. acnes) bacteria play a key role in the pathogenesis of acne vulgaris. Although our previous studies have demonstrated that vaccines targeting a surface sialidase or bacterial particles exhibit a preventive effect against P. acnes, the lack of therapeutic activities and incapability of neutralizing secretory virulence factors motivate us to generate novel immunotherapeutics. In this study, we develop an immunotherapeutic antibody to secretory Christie-Atkins-Munch-P...

  17. Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris

    OpenAIRE

    Mir Hadi Aziz-Jalali; Seyed Mehdi Tabaie; Gholamreza Esmaeeli Djavid

    2012-01-01

    Background/Purpose : Acne vulgaris is a very prevalent skin disorder and remains a main problem in practice. Recently, phototherapy with various light spectrums for acne has been used. There are some evidences that low-level laser therapy (LLLT) has beneficial effect in the treatment of acne lesions. In this study, two different wavelengths of LLLT (630 and 890 nm) were evaluated in treatment of acne vulgaris. Materials and Methods: This study was a single-blind randomized clinical trial. Pat...

  18. Treatment of Active Acne Vulgaris by Chemical Peeling Using 88% Lactic Acid

    OpenAIRE

    Khalifa E Sharquie; Adil A Noaimi; Entesar A. Al-Janabi

    2014-01-01

    Introduction: The etiopathogenesis of acne vulgaris is multifactorial, and its therapy is prolonged course that might be not accepted by many patients. Most recently TCA 35% one session peeling gave complete clearance and full remission for active acne vulgaris. Lactic acid has been used effectively as therapeutic topical agents for many skin diseases. Aim: To evaluate the efficacy and safety of chemical peeling using 88% lactic acid solution in the treatment of active acne vulgaris. ...

  19. OXIDANT/ANTIOXIDANT STATUS IN OBESE ADOLESCENT FEMALES WITH ACNE VULGARIS

    OpenAIRE

    Abulnaja Khalid

    2009-01-01

    Background and Objectives: Acne vulgaris is a distressing skin condition, which can carry with it significant psychological disability. Oxidant/antioxidant imbalance leads to increased production of free radicals, that cause many diseases. Some nutrients, along with systemic oxidative stress, have been implicated in acne vulgaris. The goal of the present study was to assess oxidant and antioxidant status in correlation with the incidence of acne vulgaris in adolescent obese females. Materia...

  20. Thyroid neoplasms after radiation therapy for adolescent acne vulgaris

    International Nuclear Information System (INIS)

    There is a potential hazard of thyroid cancer after exposure to external irradiation for the treatment of adolescent acne vulgaris. We noted a 60% incidence of thyroid carcinoma among 20 patients with such a history, who were operated on for thyroid nodules during a five-year period. Eighty-three percent of the patients with carcinoma had either a follicular or a mixed papillary-follicular carcinoma; 17% had a papillary carcinoma; 33% had regional node metastases; none had evidence of distant metastases. The interval between radiation exposure and thyroidectomy ranged from nine to 41 years. This association of thyroid neoplasms and a prior history of radiation for acne vulgaris may be coincidental and therefore remains to be proved by retrospective surveys of large numbers of treated patients with appropriate controls

  1. Newer approaches to the treatment of acne vulgaris.

    Science.gov (United States)

    Simonart, Thierry

    2012-12-01

    The multifactorial etiology of acne vulgaris makes it challenging to treat. Current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, azelaic acid, and systemic isotretinoin. Adjunctive and/or emerging approaches include topical dapsone, taurine bromamine, resveratrol, chemical peels, optical treatments, as well as complementary and alternative medications. The purpose of this paper is to discuss the therapies available for acne and their latest developments, including new treatment strategies (i.e. re-evaluation of the use of oral antibiotics and avoidance of topical antibiotic monotherapy, use of subantimicrobial antibiotic dosing, use of low-dose isotretinoin, optical treatments), new formulations (microsponges, liposomes, nanoemulsions, aerosol foams), new combinations (fixed-combination products of topical retinoids and topical antibiotics [essentially clindamycin] or benzoyl peroxide), new agents (topical dapsone, taurine bromamine, resveratrol) and their rationale and likely place in treatment. Acne vaccines, topical natural antimicrobial peptides, and lauric acid represent other promising therapies. PMID:22920095

  2. The epidemiology of acne vulgaris in late adolescence

    OpenAIRE

    Lynn DD; Umari T; Dunnick CA; Dellavalle RP

    2016-01-01

    Darren D Lynn,1 Tamara Umari,1 Cory A Dunnick,2,3 Robert P Dellavalle2–4 1Department of Dermatology, University of Colorado School of Medicine, 2Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, 3Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, 4Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Importance: Acne vulgaris is ...

  3. TRENDS OF SELF MEDICATION IN PATIENTS WITH ACNE VULGARIS

    Directory of Open Access Journals (Sweden)

    Tanzeela Khalid

    2010-07-01

    Full Text Available Back ground:Self medication is a norm in our country. One factor probably contributing to this phenomenonis over the counter sale of almost all medication without any regulation. In our dermatologypractice, we frequently encounter patients with acne vulgaris deteriorated by topical use of selfmedication. However, there is very little data to support this in our set up.Objective:To determine the percentage of acne patients using self medication in our population.Design:A cross-sectional survey.Patients and methods:One hundred and fifty patients, of any age and either sex, presenting at outpatient dermatologyclinics (Madina Teaching Hospital and Faisal Hospital, Faisalabad, from June to September2009, for the treatment of acne vulgaris were included. An in-person interview using aquestionnaire was conducted. They were asked about the use of self medication for theirdisease. Details of type of medication, its effects on disease and the source of advice were alsonoted. Objective assessment of acne grade was done by trained dermatology personnel.Data was analyzed using micro software SPSS version 17.Results:Show that 115(77% patients had used self medication. Potent topical steroids were used by72(48% patients. Majority of the patients received the advice about self medication from theirfriends (31% or relatives (27%. Temporary improvement was noticed by 47% of those whoused self medication.Conclusion:A significantly high percentage of patients (77% in our population use self medication for acnevulgaris.

  4. Efficacy and Safety of Topical Niacinamide for Acne Vulgaris

    Directory of Open Access Journals (Sweden)

    Zeynep Nurhan Saraçoğlu

    2011-06-01

    Full Text Available Background and Design: To investigate the efficacy and safety of topical 4% naicinamide gel cream in the treatment of mild to moderate acne vulgaris and to assess the quality of life of acne patients.Material and Method: Twenty-nine female patients aged 16-38 (mean: 23.57±5.42 years with mild to moderate acne vulgaris who presented in dermatology outpatient clinic were enrolled in the study. All patients applied 4% niacinamide gel cream (Vivatinell-acnecinamide gel cream® on their faces twice daily for eight weeks. The number of lesions (inflammatory and non-inflammatory was counted at 0, 2, 4 and 8 weeks. The side effects (erythema, desquamation, burning and dryness were recorded. The Skindex-29, a quality-of-life measure for patients with skin disease, was administered to the subjects at the beginning and the end of treatment.Results: The decrease in the mean number of inflammatory lesions was statistically significant at the end of the treatment (pre-treatment vs. post-treatment: 12.24 vs. 6.14; p =0.000. However, there was no statistically significant decrease in the number of non-inflammatory lesions at the end of the eight weeks. The niacinamide gel cream was generally well tolerated. There was statistically significant improvement in the Skindex-29 scale scores (p =0.000 at the end of the treatment.Conclusion: Topical 4% niacinamide gel cream may be an alternative treatment for inflammatory lesions of mild to moderate acne vulgaris.

  5. Effect of a Polyherbal Unani formulation in acne vulgaris: A preliminary study

    OpenAIRE

    Azad Hussain Lone; Shahida Habib; Tanzeel Ahmad; Mohd Anwar

    2012-01-01

    Acne vulgaris is the most common disorder treated by dermatologists. Acne is a disease of pilosebaceous units characterized by the formation of the open and closed comedones, papules, pustules, nodules and cysts. A preliminary trial was conducted in the department of Medicine, National Institute of Unani Medicine, Bangalore, India, to assess the safety and efficacy of a Polyherbal Unani Formulation (PHUF) in the management of Acne Vulgaris on scientific parameters. Twenty five patients, diagn...

  6. Quality of life in adult patients with acne vulgaris before and after treatment

    OpenAIRE

    Hikmet Akyazı; Davut Baltacı; Köksal Alpay; Çiçek Hocaoğlu

    2011-01-01

    Objectives: To investigate effect of acne treatment on quality of life in patients with acne vulgaris.Materials and methods: The study was prospective and conducted in a university hospital, enrolling the previously untreated patients with acne vulgaris. Before treatment, dermatology life quality index (DLQI) was applied to all participants of both study and control group. After 3rd and 6th months of treatment administration, DLQI tool was applied to patients in the study group, and scores we...

  7. Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences

    OpenAIRE

    Nasri, Hamid; Bahmani, Mahmoud; Shahinfard, Najmeh; Moradi Nafchi, Atefeh; Saberianpour, Shirin; Rafieian Kopaei, Mahmoud

    2015-01-01

    Context: Acne vulgaris affects about 85% of teenagers and may continue to adulthood. There are about two million visits to physicians per year for teenagers and the direct cost of acne treatment in the US exceeds $1 billion per year. Evidence Acquisition: A wide variety of treatment regimens exist for acne vulgaris including benzoil peroxide, retinoids, isotretinoids, keratolytic soaps, alpha hydroxy acids, azelaic acid, salicilic acid as well as hormonal, anti-androgen or antiseborrheic trea...

  8. Managing nonteratogenic adverse reactions to isotretinoin treatment for acne vulgaris.

    Science.gov (United States)

    Reilly, Bridget K; Ritsema, Tamara S

    2015-07-01

    Isotretinoin is the strongest, most effective oral treatment for patients with severe acne vulgaris, with remission rates of 89% and higher. Because of its potency, isotretinoin causes many adverse reactions. This article reviews common and severe adverse reactions to isotretinoin and how providers can best manage these reactions. Because of inconclusive research on the correlation between isotretinoin and depression and irritable bowel syndrome, providers should ask patients about symptoms monthly. Prescribing micronized isotretinoin and starting at the lowest dose with gradual upward titration also can help reduce the incidence of adverse reactions.

  9. Advantage of soybean isoflavone as antiandrogen on acne vulgaris

    OpenAIRE

    Riyanto, Puguh; Subchan, Prasetyowati; Lelyana, Rosa

    2015-01-01

    Background: Acne vulgaris (AV) is the commonest skin disorder, whereas soybean isoflavone had been proved as antiandrogen that is it can inhibit the enzyme 3ß-hydroxysteroid dehydrogenase,17ß-hydroxysteroid dehydrogenase and 5α-reductase. The purpose of this study is to prove the advantage of soybean isoflavone as antiandrogen on AV. Methods: this study is a clinical study using randomized pretest-posttest control group design. This study is a study with 40 samples randomized into 2 groups, i...

  10. Depression, mood change and self-esteem among adolescents aged 12-25 years with acne vulgaris in India

    OpenAIRE

    Saravanan Dharshana; Awnish Kumar Singh; Shruti Sharma; Surapaneni Krishna Mohan; Ashish Joshi

    2016-01-01

    Introduction: Acne vulgaris is a medical condition of serious concern among adolescents. This study was conducted with the aim to compare psychosocial factors such as depression, self-esteem, and social impairments between females who had acne vulgaris and those who did not have acne vulgaris. Materials and Methods: Fifty (50) female acne cases and 100 controls (hereafter nonacne participants) in the age group of 12-25 years who were seeking treatment at the Dermatology Outpatient Department ...

  11. The Use of Sodium Sulfacetamide 10%-Sulfur 5% Emollient Foam in the Treatment of Acne Vulgaris

    OpenAIRE

    Del Rosso, James Q.

    2009-01-01

    Acne vulgaris is the most common disorder encountered in ambulatory clinical practice comprising 11.3 percent of office visits to dermatologists in 2005.1 By comparison, eczematous dermatoses, psoriasis, and skin cancer accounted for 6.2, 3.5, and 10 percent of office visits, respectively.1 A variety of topical therapeutic options are available for treatment of acne vulgaris, including benzoyl peroxide, antibiotics, retinoids, azelaic acid, and sodium sulfacetamide-sulfur.2,3 Sodium sulfaceta...

  12. A review of the use of adapalene for the treatment of acne vulgaris

    OpenAIRE

    Piskin, Suleyman; Uzunali, Erol

    2007-01-01

    Acne is a disease of the pilosebaceous unit with involving abnormalities in sebum production, microbial flora changes, abnormal keratinization, and inflammation. There are several therapeutic options like topical and systemic retinoids, antibiotics, and systemic hormonal drugs. The topical retinoids a play very important role in the treatment of acne vulgaris. However, their use is limited due to skin irritation. A new generation product, adapalene is a good choice in the treatment of acne vu...

  13. Oxidant/antioxidant status in obese adolescent females with acne vulgaris

    Directory of Open Access Journals (Sweden)

    Abulnaja Khalid

    2009-01-01

    Full Text Available Background and Objectives: Acne vulgaris is a distressing skin condition, which can carry with it significant psychological disability. Oxidant/antioxidant imbalance leads to increased production of free radicals, that cause many diseases. Some nutrients, along with systemic oxidative stress, have been implicated in acne vulgaris. The goal of the present study was to assess oxidant and antioxidant status in correlation with the incidence of acne vulgaris in adolescent obese females. Materials and Methods: A total of 60 adolescent females (age 16-22 years were divided into four groups (15 each as follows: The first included obese females with acne; the second included obese females without acne; the third included non obese with acne and the fourth included non obese without acne. Fasting serum Malondialdehyde (MDA, β-carotene, and Vitamins A, E, and C were measured. In addition, platelet monoamineoxidase (MAO, and erythrocyte catechol-o-methyltransferase (COMT activities were determined. Results: It was found that serum MDA was statistically significantly decreased in obese and non obese subjects with acne, as compared to those without acne ( P < 0.05, P < 0.001 respectively. In contrast, the levels of β-carotene, vitamins A, E and C and the activity of MAO were significantly decreased in the obese and non obese with acne, as against the obese and non obese without acne. Interpretation: In obese subjects, increased fat content facilitates free radical production and lipid peroxidation, as indicated by increased MDA level, which is scavenged by the antioxidant vitamins. The decreased activity of MAO may be inhibited by free radicals and this causes psychological depression in adolescents. However there were non significant changes in the activity of COMT among the studied groups. Conclusion: The nutritional factors and a weakened antioxidant defense system may interplay, to increase the risk of psychological sequelae in acne vulgaris.

  14. Acne vulgaris and quality of life among young adults in South India

    OpenAIRE

    Priya Cinna T Durai; Dhanya G Nair

    2015-01-01

    Acne vulgaris is a chronic condition affecting more than 85% of adolescents and young adults. It is one of the most common diseases affecting humanity and its impact on quality of life (QoL) is important. The impact of acne on QoL in Indian patients remains undocumented. The study was undertaken to detect the impact of acne vulgaris and related factors that may influence the QoL. Materials and Methods: This was a hospital-based, prospective, cross-sectional, prestructured, questionnaire-based...

  15. Cosmeceuticals based on Rhealba(®) Oat plantlet extract for the treatment of acne vulgaris.

    Science.gov (United States)

    Fabbrocini, G; Saint Aroman, M

    2014-12-01

    Recent evidence suggests that acne vulgaris begins as an inflammation in and around the sebaceous gland and alterations in the lipid content of sebum, which drive hyperproliferation and increased desquamation of keratinocytes within sebaceous follicles. This prevents sebum drainage, causing the formation of microcomedones, which spontaneously regress or become acne lesions when the pilosebaceous unit is further blocked by the accumulation of corneocytes. These conditions are favourable for the proliferation of Propionibacterium acnes, which further aggravates acne by enhancing abnormal desquamation, sebum production and inflammation. Also, skin fragility due to inflammation or irritation by anti-comedogenic agents can worsen the situation. Rhealba(®) Oat plantlet extract (Pierre Fabre Dermo Cosmetique) soothes and restores fragile skin in acne by reducing inflammation and inhibits bacterial adhesion of Propionibacterium acnes. Cosmeceuticals combining Rhealba(®) Oat plantlet extract and hydro-compensating actives, which are available with or without anti-comedogenic hydroxy acids, provide a balanced, multifaceted approach for acne patients.

  16. Generation and characterization of chicken egg yolk antibodies against propionibacterium acnes for the prevention of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Karthika Selvan

    2012-01-01

    Full Text Available Introduction: Antigen-specific antibody has been widely used for immunological analysis in the field of diagnosis as well as in pure scientific research, where the IgY antibodies can be raised against P acnes antigen. Material and Methods: To produce IgY against Propionibacterium acnes, laying hens were immunized with P acnes (MTCC No: 1951 and subsequent booster injections were given. The antibodies produced were purified from the egg yolk of immunized chicken using the polyethylene glycol and ammonium sulfate precipitation method and, further, by Diethylaminoethyl (DEAE cellulose ion-exchange column chromatography. The protein fraction of IgY was isolated from the egg yolk. The separation was rapid, and the success of each step was viewed on Sodium Dodecyl Sulphate-polyacrylamide gel electrophoresis (SDS-PAGE. The reactivity of anti-P acnes was evaluated by the Enzyme-linked immunosorbent assay (ELISA test and the dot-immunoassay. Results: With ELISA, the highest titter of 1:10000 was observed on the 150 th day after vaccination. The results of dot-immunoassay suggested that anti-P acnes IgY developed a brown color as positive reaction, which showed the antigen-antibody binding even after a maximum dilution of 1/500. These results suggest that anti-acne IgY was produced and had strong specific antibody reactivity. Conclusion: The findings indicate that anti-acne IgY is worth utilizing as a preventive agent for acne vulgaris.

  17. Comparison of red and infrared low-level laser therapy in the treatment of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Mir Hadi Aziz-Jalali

    2012-01-01

    Full Text Available Background/Purpose : Acne vulgaris is a very prevalent skin disorder and remains a main problem in practice. Recently, phototherapy with various light spectrums for acne has been used. There are some evidences that low-level laser therapy (LLLT has beneficial effect in the treatment of acne lesions. In this study, two different wavelengths of LLLT (630 and 890 nm were evaluated in treatment of acne vulgaris. Materials and Methods: This study was a single-blind randomized clinical trial. Patients with mild to moderate acne vulgaris and age above 18 years and included were treated with red LLLT (630 nm and infrared LLLT (890 nm on the right and left sides of the face respectively, twice in a week for 12 sessions, and clinically assessed at baseline and weeks 2, 4, 6, and 8. Results: Twenty-eight patients were participated in this study. Ten weeks after treatment acne lesion were significantly decreased in the side treated by 630 nm LLLT (27.7±12.7 to 6.3±1.9 (P0.05. Conclusion: Red wavelength is safe and effective to be used to treat acne vulgaris by LLLT compared to infrared wavelength.

  18. Antimicrobial activities of ozenoxacin against isolates of propionibacteria and staphylococci from Japanese patients with acne vulgaris.

    Science.gov (United States)

    Nakajima, Akiko; Ikeda, Fumiaki; Kanayama, Shoji; Okamoto, Kazuaki; Matsumoto, Tatsumi; Ishii, Ritsuko; Fujikawa, Akira; Takei, Katsuaki; Kawashima, Makoto

    2016-08-01

    Ozenoxacin, a novel non-fluorinated topical quinolone, was assessed for in vitro antimicrobial activity against clinical isolates of propionibacteria and staphylococci according to the broth microdilution method recommended by the Clinical and Laboratory Standards Institute. The isolates used in this study were collected from Japanese patients with acne vulgaris during a period from 2012 to 2013. The MIC90s of ozenoxacin against Propionibacterium acnes (n=266), Propionibacterium granulosum (n=10), Staphylococcus aureus (n=23), Staphylococcus epidermidis (n=229) and other coagulase-negative staphylococci (n=82) were ≤0.06, ≤0.06, ≤0.06, 0.125 and ≤0.06 µg ml-1, respectively. The antimicrobial activity of ozenoxacin against the clinical isolates of propionibacteria and staphylococci was greater than that of five reference antimicrobial agents which have been used for the treatment of acne vulgaris. The MICs of ozenoxacin were correlated with those of nadifloxacin in P. acnes and S. epidermidis isolates. However, the MICs of ozenoxacin were 0.25-0.5 µg ml-1 and 0.5-8 µg ml-1 against nadifloxacin-resistant P. acnes (MIC: ≥8 µg ml-1; n=8) and S. epidermidis (MIC: ≥64 µg ml-1; n=10), respectively. These results indicated the potent antimicrobial activity against P. acnes and S. epidermidis isolates resistant to nadifloxacin. Topical ozenoxacin could represent an alternative therapeutic drug for acne vulgaris based on its potent antimicrobial activity against the isolates of propionibacteria and staphylococci from acne patients. PMID:27305898

  19. Antimicrobial activities of ozenoxacin against isolates of propionibacteria and staphylococci from Japanese patients with acne vulgaris.

    Science.gov (United States)

    Nakajima, Akiko; Ikeda, Fumiaki; Kanayama, Shoji; Okamoto, Kazuaki; Matsumoto, Tatsumi; Ishii, Ritsuko; Fujikawa, Akira; Takei, Katsuaki; Kawashima, Makoto

    2016-08-01

    Ozenoxacin, a novel non-fluorinated topical quinolone, was assessed for in vitro antimicrobial activity against clinical isolates of propionibacteria and staphylococci according to the broth microdilution method recommended by the Clinical and Laboratory Standards Institute. The isolates used in this study were collected from Japanese patients with acne vulgaris during a period from 2012 to 2013. The MIC90s of ozenoxacin against Propionibacterium acnes (n=266), Propionibacterium granulosum (n=10), Staphylococcus aureus (n=23), Staphylococcus epidermidis (n=229) and other coagulase-negative staphylococci (n=82) were ≤0.06, ≤0.06, ≤0.06, 0.125 and ≤0.06 µg ml-1, respectively. The antimicrobial activity of ozenoxacin against the clinical isolates of propionibacteria and staphylococci was greater than that of five reference antimicrobial agents which have been used for the treatment of acne vulgaris. The MICs of ozenoxacin were correlated with those of nadifloxacin in P. acnes and S. epidermidis isolates. However, the MICs of ozenoxacin were 0.25-0.5 µg ml-1 and 0.5-8 µg ml-1 against nadifloxacin-resistant P. acnes (MIC: ≥8 µg ml-1; n=8) and S. epidermidis (MIC: ≥64 µg ml-1; n=10), respectively. These results indicated the potent antimicrobial activity against P. acnes and S. epidermidis isolates resistant to nadifloxacin. Topical ozenoxacin could represent an alternative therapeutic drug for acne vulgaris based on its potent antimicrobial activity against the isolates of propionibacteria and staphylococci from acne patients.

  20. Research of Effect of Acne Vulgaris on The Basal Metabolic Rate

    OpenAIRE

    Selcuk Ozdogan

    2011-01-01

     Aim: To determine the relation between basal metobolic rate and acne vulgaris in the teenage population.Material and Methods: We studied basal metabolic rate in 106 boarding school boys, all 14 years old (53 with acne, 53 without acne) .BMR measurement is done from 8 points, 4 extremities and body with bioimpedance device In Body 230. Results; In the group with acne Basal Metabolic Rate was higher than control group . There is a significant difference between two groups (p=0.009). Concl...

  1. Use of Oral Contraceptives for Management of Acne Vulgaris: Practical Considerations in Real World Practice.

    Science.gov (United States)

    Harper, Julie C

    2016-04-01

    Acne vulgaris may be effectively treated with combination oral contraceptive pills (COCs) in women. COCs may be useful in any woman with acne in the absence of known contraindications. When prescribing a COC to a woman who also desires contraception, the risks of the COC are compared with the risks associated with pregnancy. When prescribing a COC to a woman who does not desire contraception, the risks of the COC must be weighed against the risks associated with acne. COCs may take 3 cycles of use to show an effect in acne lesion count reductions.

  2. Evaluation and Management of Refractory Acne Vulgaris in Adolescent and Adult Men.

    Science.gov (United States)

    McCarty, Morgan

    2016-04-01

    Acne vulgaris alters the normal skin physiology, impairing stratum corneum and transepidermal water loss. A male's normal skin physiologic state is different than a female's and may have implications when choosing treatment when the skin is altered in a disease state. Transepidermal water loss, pH, and sebum production are different between the sexes. Several underlying conditions present in male acne patients at several ages that may require a more in-depth evaluation. As knowledge of the pathogenesis of acne expands, the differences in skin physiology between the sexes may alter the manner in which male patients with acne medications are approached. PMID:27015780

  3. Severity and impact of acne vulgaris on the quality of life of adolescents in Nigeria

    Directory of Open Access Journals (Sweden)

    Ogedegbe EE

    2014-12-01

    Full Text Available Evelyn E Ogedegbe,1 Eshan B Henshaw2 1Cedarcrest Hospital, Abuja, Federal Capital Territory, Nigeria; 2Department of Medicine, Faculty of Medicine and Dentistry, University of Calabar, Cross River State, Nigeria Background: Acne vulgaris is a common skin condition, which affects most adolescents at some point in their lives. It has been found to have a significant impact on their psychological well-being and has been associated with depression and suicide ideation. Many studies have assessed the impact of acne vulgaris on the quality of life (QoL in different population subgroups around the world, but there is a dearth of reports from the African subcontinent. This study thus seeks to assess the severity of acne vulgaris and determine its effect on the QoL of adolescents in Lagos, Nigeria. Methods: In a cross-sectional survey employing a two-stage sampling method, the severity of acne vulgaris and its impact on the QoL of adolescents attending a senior secondary school in Lagos, Nigeria was assessed using the Global Acne Grading Scale (GAGS and the Cardiff Acne Disability Index (CADI, respectively. The correlation between the results of the GAGS and CADI was also determined. Results: One hundred and sixty adolescent students with acne were recruited, with males accounting for 51.9% and females 48.1%. The mean and standard deviation of the GAGS severity scores were 11.3±5.4 for males and 11.9±5.4 for females. Only one student had severe acne vulgaris (GAGS, 31–38, 10% moderate (GAGS, 19–30, and 89.4% mild (GAGS, 1–18. The overall CADI score was 3.4±3.0, which suggests mild impairment in QoL; however, the solitary student with severe acne had severe QoL impairment. There was a weak positive correlation between the GAGS and the CADI score. Conclusion: Most adolescents in our study had mild acne vulgaris, and the overall impact on their QoL was mild. However, the correlation between the psychosocial impact and acne severity was weak. There

  4. A meta-analysis of association between acne vulgaris and Demodex infestation

    Institute of Scientific and Technical Information of China (English)

    Ya-e ZHAO; Li HU; Li-ping WU; Jun-xian MA

    2012-01-01

    Until now,etiology of acne vulgaris is still uncertain.Although clinicians usually deny the association between Demodex infestation and acne vulgaris,it has been proved in some clinical practices.To confirm the association between Demodex infestation and acne vulgaris,a meta-analysis was conducted.Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISl Web of Knowledge,MEDLINE,and China National Knowledge Infrastructure (CNKI) databases.A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs)based on fixed effects models or random effects models.We enrolled the 60 Chinese and 3 English papers in this meta-analysis,which covered Turkey and 25 different provinces/municipalities in China and 42130 participants including students and residents,aged from 1 to 78 years.The pooled OR in random effects models is 2.80 (95% Cl,2.34-3.36).Stability is robust according to sensitivity analysis.The fail-safe number is 18477,suggesting that at least 18477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation.So the effect of publication bias was insignificant and could be ignored.It was concluded that acne vulgaris is associated with Demodex infestation.This indicates that when regular treatments for acne vulgaris are ineffective,examination of Demodex mites and necessary acaricidal therapies should be considered.

  5. High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study

    OpenAIRE

    Ismail Noor; Manaf Zahara; Azizan Noor

    2012-01-01

    Abstract Background The role of dietary factors in the pathophysiology of acne vulgaris is highly controversial. Hence, the aim of this study was to determine the association between dietary factors and acne vulgaris among Malaysian young adults. Methods A case–control study was conducted among 44 acne vulgaris patients and 44 controls aged 18 to 30 years from October 2010 to January 2011. Comprehensive acne severity scale (CASS) was used to determine acne severity. A questionnaire comprising...

  6. Tissue Liver X-Receptor Alpha (LXRα) Level In Acne Vulgaris

    International Nuclear Information System (INIS)

    Acne vulgaris is a disease of the pilosebaceous unit. Increased sebum lipogenesis by sebaceous gland is the major factor in the pathophysiology of acne. LXRα have been recognized in the regulation of genes involved in lipid biosynthesis. Activation of LXRα inhibits proliferation, increase lipogenesis and improve differentiation of sebocytes. Aim: To investigate the level of tissue expression of LXRα in inflammatory and non inflammatory acne lesions and in comparison with normal skin. Patients and methods: Seventeen patients with inflammatory and non inflammatory acne lesions and sixteen age and sex comparable healthy volunteers as control were included in the study. Punch skin biopsies were taken from the acne lesions and normal skin of the volunteers for detection of gene expression of LXRα by RT- PCR. Results: the level of LXRα was significantly higher in the lesional skin either inflammatory (with a mean of 1188.52 ± 129.5) or comedonal acne (with a mean of 892.52 ± 66.08) in a statistically significant manner than the controls (with a mean of 600.50 ± 95.30) where the P value was <0.001. In addition, the level of LXRα was significantly higher in inflammatory acne (with a mean of 1188.52 ± 129.5) in a statistically significant manner) than comedonal acne (with a mean of 892.52 ± 66.08) where the P value was <0.001. Conclusion: the significant increase in the level of LXRα in acne lesions compared to controls suggesting that LXRα may have a role in the pathogenesis of acne vulgaris itself and is not a consequence of inflammation. In addition, it may play a role in the progression of the disease from comedonal to inflammatory. Further studies are recommended to evaluate the therapeutic benefits of the use of LXRα antagonists as a new therapeutic modality for acne vulgaris.

  7. Topical therapy of acne vulgaris using 2% tea lotion in comparison with5% Zinc sulphate lotion

    International Nuclear Information System (INIS)

    Objective was to evaluate effectiveness of 2% tea lotion in comparisonwith 5% zinc sulphate solution in the treatment of acne vulgaris. This is asingle-blind randomly comparative therapeutic clinical trial carried out inthe Department of Dermatology, Baghdad Teaching Hospital, Iraq from June 2006to December 2007. Full history and clinical examination were studied for eachpatient regarding all relevant points of the disease, to evaluate theseverity of acne. Forty-seven patients with acne vulgaris were dividedrandomly into 2 groups and were instructed to use the following solutionstwice daily for 2 months; group A used 2% tea lotion, group B used 5% zincsulphate lotion. Patients with papulopustular lesions were included in thestudy, while patients with severe acne were excluded. The clinicalimprovement was scored by counting the number of inflammatory lesions beforeand after treatment. Forty patients completed the study, their ages rangedfrom 13-27 years with a mean+-standard deviation of 19.5+-3.5 years with 20patients in each group. Two percent tea lotion was statistically significantin decreasing the number of the inflammatory lesions in acne vulgaris, while5% zinc sulphate solution was beneficial, but did not reach statisticallysignificant level as tea lotion. Two percent of tea lotion was a goodalternative remedy to be used in the treatment of acne vulgaris and was muchsuperior than topical 5% zinc sulphate solution. (author)

  8. Evaluating of Life Quality in Patients with Acne Vulgaris Using Generic and Specific Questionnaires

    Directory of Open Access Journals (Sweden)

    Reza Ghaderi

    2013-01-01

    Full Text Available Background. Acne vulgaris is a common skin disease that can adversely affect the quality of life of patients. Objective. The aim of this study was to determine the quality of life in patients with acne vulgaris. Methods. This study was carried out on 70 patients with acne vulgaris (28 males, 42 females. All the patients filled out two Persian versions of questionnaires: short form 36 (SF-36 and Dermatology Life Quality Index (DLQI. The obtained data were analyzed by using SPSS software (version 17. Results. The scores for physical functioning, social functioning, and bodily pain domains in patients were over 70%, but the scores for role physical, general health, vitality, role emotional, and mental health in patients were under 70%. Scores on the DLQI in patients with acne vulgaris ranged from 0 to 22 (mean ± SD, 8.18 ± 4.83. After comparing mean score of DLQI with respect to gender and age, it was found that the difference between the two groups was not statistically significant. Conclusion. Acne vulgaris has a significant effect on the quality of life. There was not any significant gender or age related difference in QOL.

  9. Acne vulgaris and quality of life among young adults in South India

    Directory of Open Access Journals (Sweden)

    Priya Cinna T Durai

    2015-01-01

    Full Text Available Acne vulgaris is a chronic condition affecting more than 85% of adolescents and young adults. It is one of the most common diseases affecting humanity and its impact on quality of life (QoL is important. The impact of acne on QoL in Indian patients remains undocumented. The study was undertaken to detect the impact of acne vulgaris and related factors that may influence the QoL. Materials and Methods: This was a hospital-based, prospective, cross-sectional, prestructured, questionnaire-based study done on 140 consenting individuals, who attended the Dermatology outpatient department. Acne vulgaris was graded using simple grading system. QoL was measured using a combination of skin disease-specific (Dermatological Life Quality Index (DLQI and acne-specific (Cardiff Acne Disability Index (CADI questionnaires. Results: Majority of our study population were students (103, 73.6%. Face (139, 99.3% was the commonest site of acne and comedones 133, 95% were the commonest type of lesion. Most of the individuals 66, 47.1% were observed to have grade 1 acne. The mean DLQI score was 6.91 and the mean CADI score was 5.2. Association between the scores was statistically significant. Age, occupation, marital status, family, and treatment history played a role in affecting the QoL. Diet, smoking, and alcohol did not influence the QoL . Conclusion: Though acne had impact on patient′s QoL, it was less severe in our study. It is important for health professionals to incorporate QoL measurements when managing acne patients to provide better and appropriate care.

  10. Topical, Biological and Clinical Challenges in the Management of Patients with Acne Vulgaris.

    Science.gov (United States)

    Al-Hammadi, Anwar; Al-Ismaily, Abla; Al-Ali, Sameer; Ramadurai, Rajesh; Jain, Rishi; McKinley-Grant, Lynn; Mughal, Tariq I

    2016-05-01

    Acne vulgaris is one of the most common chronic inflammatory skin disorders among adolescents and young adults. It is associated with substantial morbidity and, rarely, with mortality. The exact worldwide incidence and prevalence are currently unknown. Current challenges involve improving understanding of the underlying pathophysiology of acne vulgaris and developing a practical treatment consensus. Expert panel discussions were held in 2013 and 2014 among a group of scientists and clinicians from the Omani and United Arab Emirate Dermatology Societies to ascertain the current optimal management of acne vulgaris, identify clinically relevant end-points and construct suitable methodology for future clinical trial designs. This article reviews the discussions of these sessions and recent literature on this topic.

  11. Topical, Biological and Clinical Challenges in the Management of Patients with Acne Vulgaris

    Science.gov (United States)

    Al-Hammadi, Anwar; Al-Ismaily, Abla; Al-Ali, Sameer; Ramadurai, Rajesh; Jain, Rishi; McKinley-Grant, Lynn; Mughal, Tariq I.

    2016-01-01

    Acne vulgaris is one of the most common chronic inflammatory skin disorders among adolescents and young adults. It is associated with substantial morbidity and, rarely, with mortality. The exact worldwide incidence and prevalence are currently unknown. Current challenges involve improving understanding of the underlying pathophysiology of acne vulgaris and developing a practical treatment consensus. Expert panel discussions were held in 2013 and 2014 among a group of scientists and clinicians from the Omani and United Arab Emirate Dermatology Societies to ascertain the current optimal management of acne vulgaris, identify clinically relevant end-points and construct suitable methodology for future clinical trial designs. This article reviews the discussions of these sessions and recent literature on this topic. PMID:27226905

  12. Topical, Biological and Clinical Challenges in the Management of Patients with Acne Vulgaris

    Directory of Open Access Journals (Sweden)

    Anwar Al-Hammadi

    2016-05-01

    Full Text Available Acne vulgaris is one of the most common chronic inflammatory skin disorders among adolescents and young adults. It is associated with substantial morbidity and, rarely, with mortality. The exact worldwide incidence and prevalence are currently unknown. Current challenges involve improving understanding of the underlying pathophysiology of acne vulgaris and developing a practical treatment consensus. Expert panel discussions were held in 2013 and 2014 among a group of scientists and clinicians from the Omani and United Arab Emirate Dermatology Societies to ascertain the current optimal management of acne vulgaris, identify clinically relevant end-points and construct suitable methodology for future clinical trial designs. This article reviews the discussions of these sessions and recent literature on this topic.

  13. Efficiency and side effects of isotretinoin usage in the treatment of acne vulgaris

    OpenAIRE

    Ahu Çiler Çıkım; Muammer Seyhan

    2008-01-01

    Background and Design: Although satisfying results with isotretinoin therapy were reported in treatment of severe or moderate but resistant acne vulgaris; the data about this treatment modality in Turkey is insufficient. Therefore we aimed to asses the clinical efficiency of isotretinoin treatment in patients with severe or moderate but resistant acne.MATERIAL-METHOD: Ninety four patients were enrolled into the study. The patients were evaluated for clinical symptoms and biochemical parameter...

  14. Clinical practice guidelines for treatment of acne vulgaris: a critical appraisal using the AGREE II instrument.

    Science.gov (United States)

    Sanclemente, Gloria; Acosta, Jorge-Luis; Tamayo, Maria-Eulalia; Bonfill, Xavier; Alonso-Coello, Pablo

    2014-04-01

    A significant number of clinical practice guidelines (CPGs) about the treatment of acne vulgaris in adolescents and adults have been published worldwide. However, little is known about the quality of CPGs in this field. The aim of this study was to appraise the methodological quality of published acne vulgaris CPGs. We performed a systematic review of published CPGs on acne vulgaris therapy from July 2002 to July 2012. Three reviewers independently assessed each CPG using the AGREE II instrument. A standardized score was calculated for each of the six domains. Our search strategy identified 103 citations but just six met our inclusion criteria. Agreement among reviewers was very good: 0.981. The domains that scored better were: "scope and purpose" and "clarity and presentation". Those that scored worse were "stakeholder involvement", "rigor of development", and "applicability". The European and the Malaysian CPGs were the only recommended with no further modifications. In addition, the Mexican, Colombian and the United States guidelines were recommended with provisos, with lower scores regarding stakeholder involvement, rigor of development and applicability. Only two guidelines clearly reported outcome measures for evaluating efficacy or included quality of life outcomes. CPGs varied regarding the consideration of light/laser therapy or consideration of complementary/alternative medicines. None of them included cost considerations of drugs such as systemic isotretinoin. In conclusion, published acne vulgaris CPGs for acne therapy vary in quality with a clear need to improve their methodological rigor. This could be achieved with the adherence to current CPGs development standards.

  15. PRESCRIPTION AUDIT OF ACNE VULGARIS IN SKIN OUTPATIENT DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL

    Directory of Open Access Journals (Sweden)

    Vishal Prakash

    2014-10-01

    Full Text Available : OBJECTIVE: To evaluate prescribing pattern in acne vulgaris cases at a tertiary care teaching hospital in south India. METHODS: Prescriptions of 120 patients of acne vulgaris who attended Dermatology OPD of a tertiary care teaching hospital were selected for study and their drug data were analyzed. RESULTS: Topical Benzoyl peroxide, adapalene, ketoconazole were prescribed as monotherapy, while aloevera, liquid paraffin and white soft paraffin as polytherapy. Azithromycin, antibiotics, anti histaminics were prescribed as systemic monotherapy and polytherapy. Statistical analysis revealed p-value was > 0.05. CONCLUSIONS: Prescription patterns were in consensus with the general guidelines, with few changes, in the choice of established therapeutic agents.

  16. Assessment of Life Quality Index Among Patients with Acne Vulgaris in a Suburban Population

    OpenAIRE

    Neirita Hazarika; Rajaprabha, Radha K

    2016-01-01

    Background and Aims: Acne vulgaris affects about 85% of adolescents, often extending into adulthood. Psychosocial impact of acne on health-related quality of life (QoL) has been identified, but it remains under-evaluated, especially in Indian patients. This study was aimed to assess the impact of acne and its sequelae on the QoL. Materials and Methods: This was a hospital-based, prospective, cross-sectional study done between June and November 2014 on 114 consenting patients above 15 years of...

  17. Safety and efficacy of tazarotene foam for the treatment of acne vulgaris

    OpenAIRE

    Stein Gold, Linda

    2013-01-01

    Erica L Epstein, Linda Stein GoldHenry Ford Hospital, Detroit, MI, USABackground: Tazarotene foam is the first topical retinoid foam approved for the treatment of acne vulgaris.Objective: To review the safety and efficacy studies of tazarotene foam in the treatment of moderate to severe acne.Methods: Five Phase I safety studies in normal controls are reviewed and two Phase III safety and efficacy studies in patients with moderate to severe acne are reviewed.Conclusion: Tazarotene foam, 0.1% w...

  18. Acne vulgaris, mental health and omega-3 fatty acids: a report of cases

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    Kim Katherine

    2008-10-01

    Full Text Available Abstract Acne vulgaris is a common skin condition, one that is associated with significant psychological disability. The psychological impairments in acne include higher rates of depression, anxiety, anger and suicidal thoughts. Despite a paucity of clinical research, patients with skin conditions and/or mental health disorders are frequent consumers of dietary supplements. An overlap may exist between nutrients that potentially have both anti-acne and mood regulating properties; examples include omega-3 fatty acids from fish oil, chromium, zinc and selenium. Here we report on five cases of acne treated with eicosapentaenoic acid and antioxidant nutrients. Self-administration of these nutrients may have improved inflammatory acne lesions and global aspects of well-being; the observations suggest a need for controlled trials.

  19. Relationship between the severity of acne vulgaris and antimicrobial resistance of bacteria isolated from acne lesions in a hospital in Japan.

    Science.gov (United States)

    Nakase, Keisuke; Nakaminami, Hidemasa; Takenaka, Yuko; Hayashi, Nobukazu; Kawashima, Makoto; Noguchi, Norihisa

    2014-05-01

    Propionibacterium acnes and Staphylococcus epidermidis are normal skin inhabitants that are frequently isolated from lesions caused by acne, and these micro-organisms are considered to contribute to the inflammation of acne. In the present study, we examined the antimicrobial susceptibilities and resistance mechanisms of P. acnes and S. epidermidis isolated from patients with acne vulgaris in a university hospital in Japan from 2009 to 2010. Additionally, we analysed the relationship between the antimicrobial resistance of P. acnes and the severity of acne vulgaris. Some P. acnes strains (18.8 %; 13/69) were resistant to clindamycin. All strains had a mutation in the 23S rRNA gene, except for one strain that expressed erm(X) encoding a 23S rRNA methylase. Tetracycline-resistant P. acnes strains were found to represent 4.3 % (3/69) of the strains, and this resistance was caused by a mutation in the 16S rRNA gene. Furthermore, three strains with reduced susceptibility to nadifloxacin (MIC = 16 µg ml(-1)) were detected. When analysing the correlation between the antimicrobial resistance of P. acnes and S. epidermidis, more than 80 % of the patients who carried clindamycin-resistant P. acnes also carried clindamycin-resistant S. epidermidis. However, no epidemic strain that exhibited antimicrobial resistance was detected in the P. acnes strains when analysed by PFGE. Therefore, our results suggest that the antimicrobial resistance of P. acnes is closely related to antimicrobial therapy. Additionally, those P. acnes strains tended to be frequently found in severe acne patients rather than in mild acne patients. Consequently, the data support a relationship between using antimicrobial agents and the emergence of antimicrobial resistance.

  20. Comparison of anxiety and depression in patients with acne vulgaris and healthy individuals

    Directory of Open Access Journals (Sweden)

    Golchai Javad

    2010-01-01

    Full Text Available Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units, which chiefly involves face and upper part of the trunk. Its prevalence is highest in adolescence, where the individual counters several psychosocial changes. Depression, suicidal thoughts, and low self esteem are reported in the patients with this disease. Aim: The goal of this study is to compare prevalence of anxiety and depression in the patients with acne vulgaris and normal population. Materials and Methods: In this cross-sectional study, 82 patients with acne vulgaris and 82 persons without acne who referred to a dermatology clinic and a specialized office for skin diseases in Rasht were studied. Anxiety and depression were evaluated by Hospital Anxiety and Depression Scale (HADS questionnaire and severity of acne was evaluated by Global Acne Grading System (GAGS. Data were analyzed by SPSS ver. 14.0 software, independent T-test, multi variate analysis of covariance (MANCOVA and chi-square test for comparison the quantitative and ordinal data, respectively; with α=0.05. Results: Prevalence of anxiety and mean of anxiety scores were 68.3% and 9.17 ± 3.52, respectively, in patients group and 39.1% and 7.10 ± 3.07, respectively, in control group in which there was a significant difference (P = 0.001. Prevalence of depression and mean of depression scores were 25.6% and 5.34 ± 3.29, respectively, in patients group and 28.1% and 5.01 ± 3.32, respectively, in control group in which there was no significant difference. Conclusion: According to high prevalence of anxiety in patients with acne vulgaris, assessment of the screening mental status of the patients by simple questionnaire such as HADS is suggested.

  1. Association between smoking habits and acne vulgaris. A case-control study

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    Alice Mannocci

    2012-09-01

    Full Text Available

    Background: acne vulgaris, is one of the most common skin disorder. Previous studies about the role of smoke in the pathogenesis of acne reported contradictory results. The aim of this study was to conduct a case-control study investigating the relationship between tobacco smoking and acne.

    Methods: a case-control study was performed during the period September 2009 - February 2010. A questionnaire was administrated to each participant, to assess the association acne - smoke. Cases were outpatients of the Dermatologic Ambulatory of the “Fiorini” Hospital, Sapienza University of Rome (Italy. Controls were age and gender-matched to the cases. The ratio cases-controls was 1:2. A univariate and a multiple logistic regression analysis were conducted; Odds Ratio (OR and the relative 95% confidence interval (95%CI were assessed. The statistical significance was set at p < 0.05.

    Results: crude OR for the association acne - smoke was 7.26 (IC=2.27-23.18; adjusted OR for sex and age was 5.47 (IC=1.67-17.97. Of 93 cases, 6 had a severe grade of acne (6.5%, 19 had an intermediate grade of acne (20.4%, and 68 had a mild grade of acne (73.1%. No one of the smokers had a severe grade of acne, one had an intermediate grade of acne and 11 had mild acne; these differences are not statistically significant.

    Conclusions: the association between acne and smoke shows an increased risk (OR=7.26 with a statistically significant CI. Moreover, people ≥ 18 years of age have twice the risk compared to persons < 18 years of age (OR=2.31.

  2. Low Dose Intermittent Isotretinoin Therapy in Moderate Acne Vulgaris

    OpenAIRE

    Belçın İzol; Emel Bülbül Başkan; Zübeyde Başar; Şükran Tunalı; Hayriye Sarıcaoğlu

    2012-01-01

    Objective: In this study, we aimed to investigate the efficiency and side effects of intermittent low dose isotretinoin therapy in moderate acne. Materials and Methods: Patients followed up at our acne outpatient clinic between September 2007 and April 2009 were evaluated. Those treated with 20 mg/day isotretinoin three times a week were included in the study. Relevant data were recorded from patient files. We recorded the age and weight of the cases, duration of acne, previous treatments, ac...

  3. Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris

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    Iraji Fariba

    2007-01-01

    Full Text Available Background: Twenty percent azelaic acid gel is recommended as a topical treatment for acne due to its favorable profile. Aim: Our objective in this study was to evaluate the efficacy of 20% azelaic acid gel in the treatment of mild to moderate acne vulgaris. Methods: This was a double blind, randomized clinical trial. Sixty patients with mild to moderate acne vulgaris were selected randomly to receive either azelaic acid gel or the vehicle gel alone. Patients were followed up every 15 days for a period of 45 days. The number of lesions and the acne severity index (ASI were recorded and compared using Student′s t-test. Results: Total lesion count was reduced by 60.6% and 19.9% by azelaic acid gel and the placebo respectively (P =0.002. ASI was reduced by 65.2% and 21.3% by azelaic acid gel and the placebo respectively (P =0.001, i.e., azelaic acid gel was 3.06 times more effective than the placebo in reducing ASI. Conclusion: Azelaic acid gel can be used as an effective treatment in mild to moderate acne vulgaris.

  4. Incidence of Acne vulgaris in the schoolsof Sari, Iran during 2003-2004

    Directory of Open Access Journals (Sweden)

    M. Golpour

    2006-01-01

    Full Text Available Background and purpose: Acne vulgaris is a very common cutaneus disorder as chronic inflammation of sebaceous glands of the skin of face, chest and back that affects everyone almost once in life time. The goal of this study was to determine the prevalence of Acne vulgaris in schools of Sari in 2003-2004.Materials and Methods: In this cross-sectional-analytical study, stratified sampling method was used, to divide male and female groups, and then a multistage random sampling was performed. All of the samples were examined for Acne vulgaris by a dermatologist, according to reliable clinical and diagnostic criteria. Questionnaires containing demographic, epidemiologic and clinical variables were filled in accordingly.Results: Two hundred samples from each stratum (400 overall, with a mean age of 15±1.51 and range of 12 of 18 years were selected. One hundred and sixty three subjects (40.75 % were affected, 50 (30.6 % male and 113 (69.4 % female with the condition being mild in 150 (92.02 % and moderate in 13 (7.98 % of the patients. The highest prevalence was in 16 years olds 52 (62.65 % and the lowest was 2 (7.4 % in 12 years olds.Conclusion: According to the relatively high prevalence of Acne vulgaris in puberty, especially in females, performing continuous epidermiologic studies can be a good step for interventional studies, and preventing psychologic problems caused by the disease and hence increasing the health level of the community.

  5. MLST typing of antimicrobial-resistant Propionibacterium acnes isolates from patients with moderate to severe acne vulgaris.

    Science.gov (United States)

    Giannopoulos, Lambros; Papaparaskevas, Joseph; Refene, Eirini; Daikos, Georgios; Stavrianeas, Nikolaos; Tsakris, Athanassios

    2015-02-01

    Molecular typing data on antimicrobial-resistant Propionibacterium strains are limited in the literature. We examined antimicrobial resistance profiles and the underlying resistance mechanisms in Propionibacterium spp. isolates recovered from patients with moderate to severe acne vulgaris in Greece. The clonallity of the resistant Propionibacterium acnes isolates was also investigated. Propionibacterium spp. isolates were detected using Tryptone-Yeast Extract-Glucose (TYG) agar plates supplemented with 4% furazolidone. Erythromycin, clindamycin, vancomycin, penicillin, co-trimoxazole, doxycycline, minocycline and ciprofloxacin MICs were determined using the gradient strip method. Erythromycin, clindamycin and tetracycline mechanisms of resistance were determined using PCR and sequencing of the domain V of 23S rRNA and 16S rRNA, as well as the presence of the ermX gene. Typing was performed using the multi locus sequence typing (MLST) methodology. Seventy nine isolates from 76 patients were collected. Twenty-three isolates (29.1%) exhibited resistance to erythromycin and clindamycin, while two additional isolates (2.5%) were resistant only to erythromycin. Resistance to tetracycline was not detected. The underlying molecular mechanisms were point mutations A2059G and A2058G. MLST typing of the P. acnes resistant isolates revealed that lineage type IA1 (ST-1, 3 and 52) prevailed (12/18; 66.7%), whilst lineage type IA2 (ST-2 and 22) accounted for five more isolates (27.8%). Susceptible isolates were more evenly distributed between ST types. Propionibacterium spp. from moderate to severe acne vulgaris in Greece are frequently resistant to erythromycin/clindamycin but not to tetracyclines, mainly due to the point mutations A2059G and A2058G. P. acnes resistant isolates were more clonally related than susceptible ones and belonged to a limited number of MLST types.

  6. Relationship between acne vulgaris and attention-deficit/hyperactivity disorder symptoms in a clinical sample of women*

    Science.gov (United States)

    Bilgic, Ayhan; Bilgic, Özlem; Çolak, Rukiye Sivri; Altınyazar, Hilmi Cevdet

    2016-01-01

    Acne vulgaris has recently been reported to be associated with elevated rates of attention deficit/hyperactivity disorder in epidemiological studies. This report examines childhood and current attention-deficit/hyperactivity disorder symptoms in a clinical sample of female adults. Ninety-one women with acne vulgaris and 53 controls were included in this study. The aforementioned symptoms were measured in participants. No significant differences were found between patients and controls in any of the measurements. Contrary to the findings of epidemiological studies, this study did not uncover a link between acne vulgaris and attention-deficit/hyperactivity disorder PMID:27192533

  7. He-Ne Laser Auricular Irradiation Plus Body Acupuncture for Treatment of Acne Vulgaris in 36 Cases

    Institute of Scientific and Technical Information of China (English)

    Sun Lihong

    2006-01-01

    In order to observe the therapeutic effects of He-Ne laser auricular irradiation plus body acupuncture for acne vulgaris, 68 cases of acne vulgaris were randomly divided into a treatment group of 36 cases treated with He-Ne laser auricular irradiation plus body acupuncture, and a control group of 32 cases treated with body acupuncture only. The results showed that the cure rate was 77.8% in the treatment group and 46.9% in the control group (P<0.05), indicating that He-Ne laser auricular irradiation plus body acupuncture may exhibit better effects for acne vulgaris.

  8. Research Progress of Acne Vulgaris%痤疮研究进展

    Institute of Scientific and Technical Information of China (English)

    王光明; 孙世成

    2013-01-01

    痤疮(Acne vulgaris)是最为常见的皮肤病,且多发于面部,对容貌影响较大,给患者造成了严重的社会心理压力,引起了国内外学者的广泛关注该文就痤疮的发病、病因、治疗及耐药性机制等方面的研究进展作一综述.%Acne vulgaris is the most common skin disease, usually in the face, which has a greater impact on the appearance. It also put serious social and psychological stress on patients, causing widespread concern of scholars at home and abroad. In this paper, we detailed the epidemiology, therapy and drug resistance mechanisms of acne, and reviewed the studies in recent years.

  9. Depression, mood change and self-esteem among adolescents aged 12-25 years with acne vulgaris in India

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    Saravanan Dharshana

    2016-01-01

    Full Text Available Introduction: Acne vulgaris is a medical condition of serious concern among adolescents. This study was conducted with the aim to compare psychosocial factors such as depression, self-esteem, and social impairments between females who had acne vulgaris and those who did not have acne vulgaris. Materials and Methods: Fifty (50 female acne cases and 100 controls (hereafter nonacne participants in the age group of 12-25 years who were seeking treatment at the Dermatology Outpatient Department (OPD of Saveetha Medical College, were enrolled in the study. Information about sociodemographic profiles, disease management, and normative perception was gathered. Further assessment of self-esteem, cognitive and behavioral factors, and self-efficacy was done. Results: Seventy-four percent (74% of the acne cases were overwhelmed by their skin condition, and this was found to be statistically significant (P < .0001. More than half (58%; P < .0001 of the acne cases experienced anger while thinking of their skin conditions. Half of the number of acne cases (52% felt that people perceived them as being dirty due to their skin condition and that it hindered them from interacting with the opposite sex. Conclusion: Adolescent females who had acne reported difficulties in overcoming the emotional disturbances occurring due to acne vulgaris.

  10. Guidelines of care for the management of acne vulgaris.

    Science.gov (United States)

    Zaenglein, Andrea L; Pathy, Arun L; Schlosser, Bethanee J; Alikhan, Ali; Baldwin, Hilary E; Berson, Diane S; Bowe, Whitney P; Graber, Emmy M; Harper, Julie C; Kang, Sewon; Keri, Jonette E; Leyden, James J; Reynolds, Rachel V; Silverberg, Nanette B; Stein Gold, Linda F; Tollefson, Megha M; Weiss, Jonathan S; Dolan, Nancy C; Sagan, Andrew A; Stern, Mackenzie; Boyer, Kevin M; Bhushan, Reva

    2016-05-01

    Acne is one of the most common disorders treated by dermatologists and other health care providers. While it most often affects adolescents, it is not uncommon in adults and can also be seen in children. This evidence-based guideline addresses important clinical questions that arise in its management. Issues from grading of acne to the topical and systemic management of the disease are reviewed. Suggestions on use are provided based on available evidence.

  11. The role of topical dermocosmetics in acne vulgaris.

    Science.gov (United States)

    Araviiskaia, E; Dréno, B

    2016-06-01

    Acne is a common chronic inflammatory disease and treatment modalities based on acne severity are well established. The role of dermocosmetics in dermatology, and in particular acne, is becoming more important as more research elucidates the mechanisms of action of products in the pathogenesis of acne. Dermocosmetics have the potential to be used as monotherapy or in combination with medical treatment. Therefore, it has become important for dermatologists to understand dermocosmetics to effectively and appropriately advise patients on their use. The objective of this review was to provide new insights into the role of traditional and novel ingredients in dermocosmetics for the treatment of acne, based on the authors' objective assessment of the published literature. The type of products discussed include: those which have a sebostatic effect, such as topical antioxidants and niacinamide; agents targeting abnormal keratinization, such as salicylic acid, lipo-hydroxy acid, alpha-hydroxy acids, retinol-based products and linoleic acid; agents targeting Propionibacterium acnes, such as lauric acid; and anti-inflammatory agents such as nicotinamide, alpha-linolenic acid and zinc salts. Despite the scientific advances in understanding these cosmetic ingredients, there still remains a lack of rigorous controlled studies in this area. PMID:26916232

  12. The Effect of Isotretinoin Administration on Anxiety and Depression Scores in Patients with Acne Vulgaris

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    Hatice Nur Azaklı

    2012-03-01

    Full Text Available Background and Design: In this study, we aimed to determine whether isotretinoin, used in the treatment of acne vulgaris, causes depression and anxiety symptoms by evaluating its effect on depression and anxiety scale scores. Materials and Methods: Eighty-nine acne vulgaris patients (F/M: 60/29, age range: 16-36 years, who had attended the outpatient clinic of the Department of Dermatology at Haseki Education and Research Hospital between 2007 and 2009, were enrolled in the study. The clinical severity of acne vulgaris was between grade 4 and grade 8 according to Allen-Smith Scale. All patients were unresponsive to several previously applied topical acne preparations or systemic antibiotics treatments and had indication for isotretinoin use. The Hospital Anxiety and Depression Scale was administered to all patients twice; before and at the end of 16-week treatment. Results: There was no significant difference between pre- and post-treatment anxiety and depression frequency and scores in patients treated with isotretinoin (p>0.05. Conclusion: The findings of the present study do not support the presence of association between isotretinoin and depression.

  13. Bacterial resistance to antibiotics in acne vulgaris: An in vitro study

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    Hassanzadeh Parvin

    2008-01-01

    Full Text Available Background: Acne vulgaris is one of the most common skin disorders in youth especially during the puberty. Objective: This in vitro study was performed to determine the antibiotic resistance and sensitivity in acne vulgaris. Materials and Methods: Samples were collected from normal skin and nodulocystic and pustular skin lesions of one hundred youngsters (64 girls, 36 boys among college students in the age range of 18-24 years old. The specimens were cultured individually on blood agar and Muller-Hinton media. The cultures were then incubated under both aerobic and anaerobic conditions for 2 to 7 days. Bacteria were identified and their resistance to common antibiotics was evaluated according to the standard procedures. Results: In aerobic culture of pustular and nodulocystic skin lesions, Staphylococcus aureus was present in 41% of subjects, Staphylococcus epidermidis in 53% and Micrococcus spp in 45% of subjucts. In anaerobic bacterial culture of pustular and nodulocystic skin lesions, Staphylococcus aureus was present in 39%, Propionibacterium acne in 33% and Staphylococcus epidermidis in 21% of subjects. The results of present study revealed that clindamycin and erythromycin were the least effective antibiotics for Propionibacterium acne while tetracycline was the least effective for Staphylococcus aureus in vitro . A synergic effect of benzoyl peroxide, erythromycin or clindamycin was noticed. Rifampin was the most effective antibiotic in vitro . Conclusion: Our results showed that rifampin was the most sensitive antibiotic in vitro for acne vulgaris. To achieve a better treatment, a combination of rifampin with other antibiotics may be more efficient. We suggest in vivo studies for better evaluation and treatment of acne patients with rifampin.

  14. Effect of the Glycemic Index of Carbohydrates on Acne vulgaris

    OpenAIRE

    Jennie C. Brand-Miller; Peter Petocz; Karola S. Stockmann; Fiona S. Atkinson; Choi, James Y. J.; Stephen Lee; Reynolds, Rebecca C.

    2010-01-01

    Acne vulgaris may be improved by dietary factors that increase insulin sensitivity. We hypothesized that a low-glycemic index diet would improve facial acne severity and insulin sensitivity. Fifty-eight adolescent males (mean age ± standard deviation 16.5 ± 1.0 y and body mass index 23.1 ± 3.5 kg/m2) were alternately allocated to high or low glycemic index diets. Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modeling assessment of insulin resistance), androgen...

  15. Treatment of acne vulgaris and prevention of acne scarring: canadian consensus guidelines.

    Science.gov (United States)

    Madden, W S; Landells, I D; Poulin, Y; Searles, G E; Smith, K C; Tan, J K; Toole, J; Zip, C M; Degreef, H

    2000-06-01

    Acne affects approximately 95% of the population at some point during their lifetime.1 This common disorder can range from mild to severe forms, cause sometimes extensive scarring, and can last well into the fourth and fifth decades. Effective therapeutic agents are available to both treat acne and prevent ongoing disease. Despite this, dermatologists frequently see patients with significant acne scarring because many patients delay seeking medical attention for acne and many practitioners procrastinate over using effective antiscarring options. In patients who already demonstrate scarring, repeated courses of antibiotics only result in recurring acne and additional scarring. This, in turn, exacerbates the despair and other adverse psychosocial effects of the disease. There are a variety of agents and devices to help acne patients with scarring. However, successful treatment cannot be guaranteed, and in most cases residual scarring will be evident. Thus, the most effective way of managing acne scarring is to prevent its occurrence in the first place. Although we currently have a number of effective antiacne agents to control the disease, such as antibiotics and hormonal agents, isotretinoina is the only agent that has been shown to induce long-term drug-free remission and curative potential. PMID:11749902

  16. Treatment of acne vulgaris and prevention of acne scarring: canadian consensus guidelines.

    Science.gov (United States)

    Madden, W S; Landells, I D; Poulin, Y; Searles, G E; Smith, K C; Tan, J K; Toole, J; Zip, C M; Degreef, H

    2000-06-01

    Acne affects approximately 95% of the population at some point during their lifetime.1 This common disorder can range from mild to severe forms, cause sometimes extensive scarring, and can last well into the fourth and fifth decades. Effective therapeutic agents are available to both treat acne and prevent ongoing disease. Despite this, dermatologists frequently see patients with significant acne scarring because many patients delay seeking medical attention for acne and many practitioners procrastinate over using effective antiscarring options. In patients who already demonstrate scarring, repeated courses of antibiotics only result in recurring acne and additional scarring. This, in turn, exacerbates the despair and other adverse psychosocial effects of the disease. There are a variety of agents and devices to help acne patients with scarring. However, successful treatment cannot be guaranteed, and in most cases residual scarring will be evident. Thus, the most effective way of managing acne scarring is to prevent its occurrence in the first place. Although we currently have a number of effective antiacne agents to control the disease, such as antibiotics and hormonal agents, isotretinoina is the only agent that has been shown to induce long-term drug-free remission and curative potential.

  17. [Effective and safe pharmacotherapy of acne vulgaris and treatment of sun-damaged skin].

    Science.gov (United States)

    Fendrich, Z; Jandová, E; Finsterlová, M

    2000-03-01

    An inevitable condition for the pharmacist is a basic knowledge of dermatological changes which are prominent in acne and solar impairment of the skin to be able to recommend in a qualified manner an effective and safe treatment to the patient. However, sufferers of the more serious forms of acne should always be referred to their general practitioner, or preferentially a dermatologist. Acne vulgaris is an androgen-induced disorder, but three major mechanisms for the development of the disease have been identified: hypertrophy of the sebaceous gland, hyperkatosis of the follicular epithelium, and proliferation of microbial flora, particularly Propionibacterium acnes. The basis of all lesions is the microcomedone which is developed into the ripe comedone. Inflammatory lesions are thought to be due to proliferation of P. acnes. In the selfmedication of common acne, benzoyl peroxide, which in a 5-10% lotion exerts antimicrobial and keratolytic properties, proved to be useful. Patients appreciate a lot its instant effect which is visible after just one day of treatment. Salicylic acid is another effective drug, which, when used on the long-term basis, has comedolytic properties; it reduces the number of microcomedones and counteracts plugging of the follicles. In addition, in healthy young women who take oral contraception, a triphasic combined oral preparations of contraceptives with newer progestins, notably with norgestimmate, which is practically free of androgenic effects, are recommended with advantage for the treatment of moderate acne vulgaris without any adverse effects. Solar impairment of the skin, the so-called solar ageing, is clinically indistinguishable from biological ageing. Changes connected with solar impairment appear mostly in the dermis, where solar elastosis develops, the skin gets drier and wrinkle formation appears. For the treatment, hydroxy acids are recommended, namely salicylic acid, which is very effective, because in combination with a

  18. Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience

    OpenAIRE

    Kim, Grace K.; Del Rosso, James Q.

    2012-01-01

    Oral spironolactone has been used for over two decades in the dermatological setting. Although it is not generally considered a primary option in the management of female patients with acne vulgaris, the increase in office visits by post-teenage women with acne vulgaris has recently placed a spotlight on the use of this agent in this subgroup of patients. This article reviews the literature focusing on the use of oral spironolactone in this subset of women with acne vulgaris, including discus...

  19. Thyroid abnormalities in patients previously treated with irradiation for acne vulgaris

    International Nuclear Information System (INIS)

    Of 1,203 patients who received radiation treatment for acne vulgaris between 1940 and 1968, 302 patients were recalled and examined, 121 at Geisinger Medical Center and the remainder by their local physicians. Radiation records were reviewed on all patients. Lead-rubber and cones had been used as shielding. Mean age at the time of exposure was 21 years and mean total exposure was 692 R. Palpable nodular thyroid disease was found in eight patients (2.6%). Of these, thyroid carcinoma was detected in two patients (0.66%). Although the number of patients examined was small, the incidence of carcinomas was unexpectedly high. We conclude that follow-up examination is worthwhile for patients previously treated by irradiation for acne vulgaris

  20. Thyroid abnormalities in patients previously treated with irradiation for acne vulgaris

    International Nuclear Information System (INIS)

    Of 1203 patients who received radiation treatment for acne vulgaris between 1940 and 1968, 302 were recalled and examined, 121 at Geisinger Medical Center and the remainder by their local physicians. Radiation records were reviewed on all patients. Lead-rubber and cones had been used as shielding. Mean age at the time of exposure was 21 years and mean total exposure was 692 R. Palpable nodular thyroid disease was found in eight patients (2.6%). Of these, thyroid carcinoma was detected in two patients (0.66%). Although the number of patients examined was small, the incidence of carcinomas was unexpectedly high. The authors conclude that follow-up examination is worthwhile for patients previously treated by irradiation for acne vulgaris

  1. Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris.

    Science.gov (United States)

    Khodaeiani, Effat; Fouladi, Rohollah Fadaei; Amirnia, Mehdi; Saeidi, Majid; Karimi, Elham Razagh

    2013-08-01

    Nicotinamide and clindamycin gels are two popular topical medications for acne vulgaris. This study aimed to compare efficacy of the topical 4% nicotinamide and 1% clindamycin gels in these patients. In this randomized, double-blind clinical trial, patients with moderate inflammatory facial acne vulgaris were randomly allocated to receive either topical 4% nicotinamide (n = 40) or 1% clindamycin gels (n = 40) twice daily. In each group, they were further categorized in two subgroups with oily and non-oily types of facial skin. The Cook's acne grade was determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased from an average of 5.93 ± 0.83 at baseline to 4.03 ± 1.33 at week 4 and 2.08 ± 1.59 at week 8 in nicotinamide receivers, and from an average of 5.70 ± 0.94 at baseline to 3.85 ± 1.66 at week 4 and 2.03 ± 1.53 at week 8 in the clindamycin group (within-group P  0.05). Comparing with each other, nicotinamide and clindamycin gels were significantly more efficacious in oily and non-oily skin types, respectively. No major side effect was encountered by any patient. Skin type is a significant factor in choosing between topical nicotinamide and clindamycin in patients with acne vulgaris.

  2. Analytical study of treatment outcome of various topical modalities in Acne Vulgaris

    OpenAIRE

    Patil, Mahadevi; Bendigeri, Jyoti

    2015-01-01

    Acne vulgaris is a multifactorial disease affecting the pilosebaceous follicle characterized by comedones, papules, pustules, nodules, cysts and scars. This study constituted 120 patients and was conducted at Department of Dermatology, Venereology & Leprology at Basaveshwar Teaching & General Hospital, attached to Mahadevappa Rampure Medical College, Gulbarga during the period from September 2010 to August 2012. It was aimed to find out the outcome of treatment with various topical mo...

  3. Clinical efficacy of Kumkumadi Ghrita prepared by Kesar and Nagakesar on Mukhadushika (Acne vulgaris)

    OpenAIRE

    PK Prajapati; Amrutia A; Rohit Sharma; BJ Patigiri

    2014-01-01

    Introduction: In spite of large number of treatment options for Mukhdushika (Acne vulgaris), efforts are still carried out by medical society to bring out more effective treatment. Kumkumadi Ghrita (KG) is one of the highly valued formulations among Ayurvedic physicians, commonly recommended in Mukhdushika. Kesar (stigma of Crocus sativus Linn) is a prime ingredient in the formulation. Due to high cost and increased adulteration trends in Kesar, another botanical ‘Nagakesar’ (stigma of Mes...

  4. Severity and impact of acne vulgaris on the quality of life of adolescents in Nigeria

    OpenAIRE

    Ogedegbe EE; Henshaw EB

    2014-01-01

    Evelyn E Ogedegbe,1 Eshan B Henshaw2 1Cedarcrest Hospital, Abuja, Federal Capital Territory, Nigeria; 2Department of Medicine, Faculty of Medicine and Dentistry, University of Calabar, Cross River State, Nigeria Background: Acne vulgaris is a common skin condition, which affects most adolescents at some point in their lives. It has been found to have a significant impact on their psychological well-being and has been associated with depression and suicide ideation. Many studies have assessed...

  5. Profile of clindamycin phosphate 1.2%/benzoyl peroxide 3.75% aqueous gel for the treatment of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Nguyen TA

    2015-10-01

    Full Text Available Tuyet A Nguyen,1,2 Lawrence F Eichenfield1,31Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, CA, 2Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 3Department of Dermatology, University of California, San Diego, La Jolla, CA, USA Abstract: Acne vulgaris is a common and chronic skin disease, and is a frequent source of morbidity for affected patients. Treatment of acne vulgaris is often difficult due to the multifactorial nature of this disease. Combination therapy, such as that containing clindamycin and benzoyl peroxide, has become the standard of care. Several fixed formulations of clindamycin 1% and benzoyl peroxide of varying concentrations are available and have been used with considerable success. The major limitation is irritation and dryness from higher concentrations of benzoyl peroxide, and a combination providing optimal efficacy and tolerability has yet to be determined. Recently, a clindamycin and benzoyl peroxide 3.75% fixed combination formulation was developed. Studies have suggested that this formulation may be a safe and effective treatment regimen for patients with acne vulgaris. Here, we provide a brief review of acne pathogenesis, benzoyl peroxide and clindamycin, and profile a new Clindamycin-BP 3.75% fixed combination gel for the treatment of moderate-to-severe acne vulgaris. Keywords: acne vulgaris, benzoyl peroxide, clindamycin

  6. Efficacy of Intense Pulsed Light Therapy in the Treatment of Facial Acne Vulgaris: Comparison of Two Different Fluences

    Science.gov (United States)

    Patidar, Monika V; Deshmukh, Ashish Ramchandra; Khedkar, Maruti Yadav

    2016-01-01

    Background: Acne vulgaris is the most common disease of the skin affecting adolescents and young adults causing psychological distress. The combination of antibiotic resistance, adverse effects of topical and systemic anti acne medications and desire for high tech approaches have all led to new enthusiasm for light based acne treatment. Intense pulse light (IPL) therapy has three modes of action in acne vulgaris i.e., photochemical, photo thermal and photo immunological. Aims: (1) to study efficacy of IPL therapy in facial acne vulgaris. (2) To compare two fluences - one normal and other subnormal on right and left side of face respectively. Methods: (Including settings and design and statistical analysis used). Total 45 patients in age group 16 to 28 years with inflammatory facial acne vulgaris were included in prospective study. Baseline data for each patient was recorded. All patients were given 4 sittings of IPL at 2 weeks interval and were followed for 2 months every 2 weeks. Fluence used was 35J/cm2 on right and 20J/cm2 on left side. Percentage reduction in lesion count was calculated at each sitting and follow up and graded as mild (0-25%), moderate (26-50%), good (51-75%) and excellent (76-100%). Side effects were noted. The results were analysed using Mann-Whitney Test. Results: On right side, excellent results were achieved in 10(22%), good in 22(49%) and moderate in 13(29%) patients. On left side excellent were results achieved in 7(15%), good in 19(42%) and moderate in 16(43%) patients. There was no statically significant difference noted in efficacy of two fluences used in treatment of facial acne vulgaris. Conclusions: IPL is a effective and safe option for inflammatory acne vulgaris with minimal reversible side effects. Subnormal fluence is as effective as normal fluence in Indian skin. PMID:27688446

  7. Efficacy of intense pulsed light therapy in the treatment of facial acne vulgaris: Comparison of two different fluences

    Directory of Open Access Journals (Sweden)

    Monika V Patidar

    2016-01-01

    Full Text Available Background: Acne vulgaris is the most common disease of the skin affecting adolescents and young adults causing psychological distress. The combination of antibiotic resistance, adverse effects of topical and systemic anti acne medications and desire for high tech approaches have all led to new enthusiasm for light based acne treatment. Intense pulse light (IPL therapy has three modes of action in acne vulgaris i.e., photochemical, photo thermal and photo immunological. Aims: (1 to study efficacy of IPL therapy in facial acne vulgaris. (2 To compare two fluences - one normal and other subnormal on right and left side of face respectively. Methods: (Including settings and design and statistical analysis used. Total 45 patients in age group 16 to 28 years with inflammatory facial acne vulgaris were included in prospective study. Baseline data for each patient was recorded. All patients were given 4 sittings of IPL at 2 weeks interval and were followed for 2 months every 2 weeks. Fluence used was 35J/cm2 on right and 20J/cm2 on left side. Percentage reduction in lesion count was calculated at each sitting and follow up and graded as mild (0-25%, moderate (26-50%, good (51-75% and excellent (76-100%. Side effects were noted. The results were analysed using Mann-Whitney Test. Results: On right side, excellent results were achieved in 10(22%, good in 22(49% and moderate in 13(29% patients. On left side excellent were results achieved in 7(15%, good in 19(42% and moderate in 16(43% patients. There was no statically significant difference noted in efficacy of two fluences used in treatment of facial acne vulgaris. Conclusions: IPL is a effective and safe option for inflammatory acne vulgaris with minimal reversible side effects. Subnormal fluence is as effective as normal fluence in Indian skin.

  8. Safety and efficacy of adapalene gel 0.1% in acne vulgaris: Results of a post-marketing surveillance study

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    Percy S

    2003-07-01

    Full Text Available Introduction: Adapalene is a novel retinoid indicated for the topical treatment of acne vulgaris. The drug was introduced in India in 2001. Aims: A post-marketing surveillance study was conducted to assess the safety and efficacy of adapalene gel 0.1% when used as monotherapy or in combination with other anti-acne agents in Indian patients of acne vulgaris. Material and Methods: A 12-week, multicentre, open-label, non-comparative study involving 571 patients from 21 centers across India was conducted between January and September of 2002. Concomitant prescription of other anti-acne drugs was permitted, if needed. Results: Of the 571 patients, 441 completed the treatment as per protocol. At the end of therapy, 96.3% of patients showed an improvement in their acne from baseline, with greater than 75% improvement seen in two-thirds of patients. Adverse events were reported in 24% of the patients, none of which were serious. The tolerability of therapy was rated as excellent/good in 81% of patients by physicians and in 78% by the patients. Conclusion: Adapalene gel 0.1% is a safe and effective topical agent in the treatment of mild to moderate acne vulgaris in Indian patients. It may be safely combined with other topical and oral anti-acne agents.

  9. The impact of acne vulgaris on quality of life and psychic health in young adolescents in Greece. Results of a population survey *

    OpenAIRE

    Eleni Tasoula; Stamatis Gregoriou; John Chalikias; Dimitris Lazarou; Ifigenia Danopoulou; Andreas Katsambas; Dimitris Rigopoulos

    2012-01-01

    BACKGROUND: Acne vulgaris can severely affect social and psychological functioning. OBJECTIVE: The aim of this study was to investigate the impact of acne vulgaris and its severity on Quality of Life of young adolescents in Greece. METHODS: We conducted a questionnaire based survey among 1560 adolescent between the ages of 11 and 19 years old and 1531 of these were completed. Adolescents with acne filled all the questions including the Children Dermatology Life Quality Index. Adolescents with...

  10. Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine.

    Science.gov (United States)

    Bowe, W; Patel, N B; Logan, A C

    2014-06-01

    Acne vulgaris has long been postulated to feature a gastrointestinal mechanism, dating back 80 years to dermatologists John H. Stokes and Donald M. Pillsbury. They hypothesised that emotional states (e.g. depression and anxiety) could alter normal intestinal microbiota, increase intestinal permeability, and contribute to systemic inflammation. They were also among the first to propose the use of probiotic Lactobacillus acidophilus cultures. In recent years, aspects of this gut-brain-skin theory have been further validated via modern scientific investigations. It is evident that gut microbes and oral probiotics could be linked to the skin, and particularly acne severity, by their ability to influence systemic inflammation, oxidative stress, glycaemic control, tissue lipid content, and even mood. This intricate relationship between gut microbiota and the skin may also be influenced by diet, a current area of intense scrutiny by those who study acne. Here we provide a historical background to the gut-brain-skin theory in acne, followed by a summary of contemporary investigations and clinical implications. PMID:23886975

  11. Topical application of ALA PDT for the treatment of moderate to severe acne vulgaris

    Science.gov (United States)

    Wang, Xiu-Li; Wang, Hong-Wei; Zhang, Ling-Lin; Su, Lina; Guo, Ming-Xia; Huang, Zheng

    2009-06-01

    Objectives: To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)- medicated photodynamic therapy (ALA PDT) for the treatment of moderate to severe acne vulgaris. Methods: Sixteen Chinese patients with moderate to severe facial acne were treated with 1-3 courses of ALA PDT. ALA cream (3%) was freshly prepared and applied to acne lesions for 3-4 h. The lesions were irradiated by a 635 nm diode laser at dose levels of 60 - 80 J/cm2 at 100 mW/cm2. Clinical assessments were conducted before and after treatment up to 3 months. Results: All patents showed response to ALA PDT. Complete clearance was seen in 10 patients (62.5%) and partial clearance in 6 patients (37.5%). One case showed recurrence after complete clearance at 2 months and another two showed recurrence after complete clearance at 3 months. However, the number of new lesions were significantly reduced. Adverse effects were minimal. Conclusions: The results of this preliminary clinical study is encouraging. ALA PDT is a simple, safe and useful therapeutic option for the treatment of moderate to severe acne. Further studies to evaluate the treatment with a larger number of patients and for a longer period of follow-up are needed.

  12. Demographic Features, Beliefs And Socio–Psychological Impact Of Acne Vulgaris Among Its Sufferers In Two Towns In Nigeria

    OpenAIRE

    Ikaraoha CI; Taylor GOL; Anetor JI; Igwe CU; Ukaegbu QO; Nwobu GO; Mokogwu ATH

    2005-01-01

    There is paucity of reports in the demographic knowledge, belief and socio-psychological impact of acne vulgaris sufferers towards the disorder in a black population. This is the first study from Nigeria designed to address this issue. A total of 174 facial acne sufferers completed a self-administered questionnaire, which contained several items mentioning different areas in their belief, knowledge, perception, severity, socio-psychological impact and medication attention. The findings were d...

  13. Assessment of anxiety and depression in adolescents with acne vulgaris related to the severity of clinical features and gender

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    Nermina Kurtalić

    2010-11-01

    Full Text Available Objective. To determine anxiety and depression levels in adolescents with acne vulgaris in relation to clinical severity and gender. Patients and methods. Using a sectional study, the anxiety and depression level was analyzed of 90 adolescents of both sexes, aged 16 to 21 years, who were suffering from acne vulgaris. The study was conducted between February 1st 2008 and January 31st 2009 at the Dermatovenerology department of the Cantonal Hospital “Dr. Irfan Ljubijankić”, Bihac. According to the type of efflorescence, its localization and severity of clinical features, respondents were classified in three groups: the first group consisted of adolescents with mild forms of acne, the second group had moderate forms of acne and the third had severe forms of acne. Evaluation of anxiety levels in patients with acne vulgaris was made using STAI questionnaire (Spielberger’s state and trait Anxiety Inventory that consists of 20 questions about the essential characteristics of anxiety as the condition, and the level of depression was determined using the BDS-scale (Back Depression Inventory which consists of 18 items that were used by the respondents to perform self-evaluation of depression level. Results. In the study group there were 54 (60% female respondents and 36 (40% male, mean age 17.5 years (range 15.6-20.6. Of the total number of patients with acne vulgaris, nine of them or 10% (4 female and 5 male had a mild form of acne (first group, 72 of them or 80% (46 female and 26 male a moderate form of acne (second group and 9 of them or 10 % (4 female and 5 male a severe form of acne (third group (p > 0.95. 1.1% of the respondents had an exceptionally low anxiety level, 13.3% had low level, moderate 76.8% and 8.8% had a high level. 37.8% had distinct signs of depression, the risk group consisted of 44.4%, and a normal value was found in 17.7%. The values of the STAI questionnaire expressed as median (range in the first, second and third groups

  14. TNFR 2 M196R Polymorphism and Acne Vulgaris in Han Chinese:A Case-control Study

    Institute of Scientific and Technical Information of China (English)

    田黎明; 谢红付; 杨婷; 胡耀华; 李吉; 王玮蓁

    2010-01-01

    In this case-control study,the relationship between M196R(676 T→G) variant in exon 6 of tumor necrosis factor receptor type 2(TNFR2) gene and genetic susceptibility of acne vulgaris in Han Chinese was investigated.A total of 93 acne vulgaris patients and 90 healthy subjects from Han Chinese ethnic group were enrolled in this study.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique was adopted to analyze the single nucleotide polymorphisms(SNPs) of TNFR2 M196R gene,and to ...

  15. Prevalence of acne vulgaris in Chinese adolescents and adults: a community-based study of 17,345 subjects in six cities.

    Science.gov (United States)

    Shen, Yiwei; Wang, Tinglin; Zhou, Cheng; Wang, Xiaoyan; Ding, Xiaolan; Tian, Shan; Liu, Ying; Peng, Guanghui; Xue, Shuqi; Zhou, June; Wang, Renli; Meng, Xuemei; Pei, Guangde; Bai, Yunhua; Liu, Qing; Li, Hang; Zhang, Jianzhong

    2012-01-01

    Acne vulgaris is a common skin condition in adolescents. The prevalence of acne is thought to vary between ethnic groups and countries. A large-scale community-based study was performed in six cities in China to determine the prevalence and possible risk factors for acne in the Chinese population. A total of 17,345 inhabitants were included in this study. Of these, 1,399 were found to have acne. No acne was found in subjects under 10 years of age, and only 1.6% in the 10-year-old group had acne. Prevalence then increased rapidly with age, up to 46.8% in the 19-year-old group. After that, it declined gradually with age. Acne was rare in people over 50 years of age. In subjects in their late teens and 20s, acne was more prevalent in males, while in those over 30 years of age it was more prevalent in females. In subjects with acne, 68.4% had mild; 26.0% had moderate and 5.6% had severe acne. In adult acne, persistent acne was much more common (83.3%) than late-onset acne (16.7%). Smoking and drinking were found to be associated with adolescent acne, while no association was found between diet and acne. These results suggest that the prevalence of acne in the Chinese population is lower than that in Caucasian populations, and that adult acne is not uncommon in Chinese subjects. PMID:21710106

  16. Efficacy of local application of an Unani formulation in acne vulgaris

    OpenAIRE

    Sultana, Shabiya; Zulkifle, Mohd; Ansari, Abdul Haseeb; Shahnawaz,

    2015-01-01

    Background and Objectives: Buthūr-i-Labaniyya (Acne vulgaris) is affecting up to 80% of adolescents and many adults at different stages of life. It is one of the commonest skin disorders which appears on cheeks and nose as white eruptions that seems like solidified milk drops. These eruptions are treated by drugs having properties of tajfīf wa taḥlīl (desiccant and resolving), as mentioned by Ibne Sina. Daood Antaki in his book Tazkira Oolulalbab recommends the local application of a paste of...

  17. South-East Asia study alliance guidelines on the management of acne vulgaris in South-East Asian patients.

    Science.gov (United States)

    Goh, Chee Leok; Abad-Casintahan, Flordeliz; Aw, Derrick Chen Wee; Baba, Roshidah; Chan, Lee Chin; Hung, Nguyen Thanh; Kulthanan, Kanokvalai; Leong, Hoe Nam; Medina-Oblepias, Marie Socouer; Noppakun, Nopadon; Sitohang, Irma Bernadette; Sugito, Titi Lestari; Wong, Su-Ni

    2015-10-01

    The management of acne in South-East Asia is unique, as Asian skin and local variables require a clinical approach unlike that utilized in other parts of the world. There are different treatment guidelines per country in the region, and a group of leading dermatologists from these countries convened to review these guidelines, discuss current practices and recent advances, and formulate consensus guidelines to harmonize the management of acne vulgaris in the region. Emphasis has been placed on formulating recommendations to impede the development of antibiotic resistance in Propionibacterium acnes. The group adopted the Acne Consensus Conference system for grading acne severity. The group recommends that patients may be treated with topical medications including retinoids, benzoyl peroxide (BPO), salicylic acid, a combination of retinoid and BPO, or a combination of retinoids and BPO with or without antibiotics for mild acne; topical retinoid with topical BPO and a oral antibiotic for moderate acne; and oral isotretinoin if the patient fails first-line treatment (a 6- or 8-week trial of combined oral antibiotics and topical retinoids with BPO) for severe acne. Maintenance acne treatment using topical retinoids with or without BPO is recommended. To prevent the development of antibiotic resistance, topical antibiotics should not be used as monotherapy or used simultaneously with oral antibiotics. Skin care, comprised of cleansing, moisturizing and sun protection, is likewise recommended. Patient education and good communication is recommended to improve adherence, and advice should be given about the characteristics of the skin care products patients should use.

  18. The long-term effect of 1550 nm erbium:glass fractional laser in acne vulgaris.

    Science.gov (United States)

    Liu, Yale; Zeng, Weihui; Hu, Die; Jha, Smita; Ge, Qin; Geng, Songmei; Xiao, Shengxiang; Hu, Guanglei; Wang, Xiaoxiao

    2016-04-01

    We evaluated the short-term and long-term effects of the 1550 nm erbium:glass (Er:glass) fractional laser in the treatment of facial acne vulgaris. Forty-five (9 male and 36 female) acne patients were treated 4 times at 4-week intervals with the following parameters: 169 spot density and 15-30 mJ/cm(2) fluence. There was no control group. The laser spots were adjustable (maximum overlap: 20%) according to the treatment area, and delivered in rows in order to cover all the face. Clinical photographs were taken. The IGA scores and lesion counts were performed for each treatment. Their current state was obtained by phone call follow-up to determine the long-term effect and photographs were offered by themselves or taken in hospital. After four treatments, all patients had an obvious reduction of lesion counts and IGA score and the peak lesion counts decreased to 67.7% after the initial four treatment sessions. For long-term effect, 8 patients lost follow-up, hence 37 patients were followed-up. 8 patients were 2-year follow up, 27 at the 1-year follow-up, and all patients at the half-year follow-up. The mean percent reduction was 72% at the half-year follow-up, 79 at the 1-year follow-up and 75% at the 2-year follow-up. Side effects and complications were limited to transient erythema and edema, and few patients suffered from transient acne flare-ups and sensitivity. All patients responded that their skin was less prone to oiliness. In conclusion, acne can be successfully treated by 1550 nm Er:glass fractional laser, with few side effects and prolonged acne clearing. PMID:26796708

  19. Effect of the Glycemic Index of Carbohydrates on Acne vulgaris

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    Jennie C. Brand-Miller

    2010-10-01

    Full Text Available Acne vulgaris may be improved by dietary factors that increase insulin sensitivity. We hypothesized that a low-glycemic index diet would improve facial acne severity and insulin sensitivity. Fifty-eight adolescent males (mean age ± standard deviation 16.5 ± 1.0 y and body mass index 23.1 ± 3.5 kg/m2 were alternately allocated to high or low glycemic index diets. Severity of inflammatory lesions on the face, insulin sensitivity (homeostasis modeling assessment of insulin resistance, androgens and insulin-like growth factor-1 and its binding proteins were assessed at baseline and at eight weeks, a period corresponding to the school term. Forty-three subjects (n = 23 low glycemic index and n = 20 high glycemic index completed the study. Diets differed significantly in glycemic index (mean ± standard error of the mean, low glycemic index 51 ± 1 vs. high glycemic index 61 ± 2, p = 0.0002, but not in macronutrient distribution or fiber content. Facial acne improved on both diets (low glycemic index −26 ± 6%, p = 0.0004 and high glycemic index −16 ± 7%, p = 0.01, but differences between diets did not reach significance. Change in insulin sensitivity was not different between diets (low glycemic index 0.2 ± 0.1 and high glycemic index 0.1 ± 0.1, p = 0.60 and did not correlate with change in acne severity (Pearson correlation r = −0.196, p = 0.244. Longer time frames, greater reductions in glycemic load or/and weight loss may be necessary to detect improvements in acne among adolescent boys.

  20. The long-term effect of 1550 nm erbium:glass fractional laser in acne vulgaris.

    Science.gov (United States)

    Liu, Yale; Zeng, Weihui; Hu, Die; Jha, Smita; Ge, Qin; Geng, Songmei; Xiao, Shengxiang; Hu, Guanglei; Wang, Xiaoxiao

    2016-04-01

    We evaluated the short-term and long-term effects of the 1550 nm erbium:glass (Er:glass) fractional laser in the treatment of facial acne vulgaris. Forty-five (9 male and 36 female) acne patients were treated 4 times at 4-week intervals with the following parameters: 169 spot density and 15-30 mJ/cm(2) fluence. There was no control group. The laser spots were adjustable (maximum overlap: 20%) according to the treatment area, and delivered in rows in order to cover all the face. Clinical photographs were taken. The IGA scores and lesion counts were performed for each treatment. Their current state was obtained by phone call follow-up to determine the long-term effect and photographs were offered by themselves or taken in hospital. After four treatments, all patients had an obvious reduction of lesion counts and IGA score and the peak lesion counts decreased to 67.7% after the initial four treatment sessions. For long-term effect, 8 patients lost follow-up, hence 37 patients were followed-up. 8 patients were 2-year follow up, 27 at the 1-year follow-up, and all patients at the half-year follow-up. The mean percent reduction was 72% at the half-year follow-up, 79 at the 1-year follow-up and 75% at the 2-year follow-up. Side effects and complications were limited to transient erythema and edema, and few patients suffered from transient acne flare-ups and sensitivity. All patients responded that their skin was less prone to oiliness. In conclusion, acne can be successfully treated by 1550 nm Er:glass fractional laser, with few side effects and prolonged acne clearing.

  1. Acne

    Science.gov (United States)

    ... Hair care Douching Makeup Tanning Tattoos and piercing Cosmetic surgery Points about shoes Backpack safety Protecting your ears ... Acne Whether you call them pimples, zits, or acne, lots of teens find skin problems confusing and upsetting. But you ...

  2. Acne

    Science.gov (United States)

    Acne is a common skin disease that causes pimples. Pimples form when hair follicles under your skin ... neck, back, chest, and shoulders. Anyone can get acne, but it is common in teenagers and young ...

  3. Acne vulgar e bem-estar em acadêmicos de medicina Acne vulgaris and well-being in medical students

    Directory of Open Access Journals (Sweden)

    Jonas Ribas

    2008-12-01

    Full Text Available FUNDAMENTOS - Observa-se comorbidade psiquiátrica em 40% dos pacientes dermatológicos adultos, sendo a acne vulgar de interesse da psicodermatologia por ter entre suas complicações seqüelas psicossociais. OBJETIVOS - Estabelecer a relação entre acne e o status de bem-estar. MÉTODOS - Estudo de caso-controle com dados coletados a partir do Índice de Bem-Estar da Organização Mundial da Saúde, por meio de entrevistas com dois grupos de 50 acadêmicos de medicina, sendo um com acne e outro sem acne. RESULTADOS - Foi verificado que 26% dos acadêmicos do grupo de casos e 24% do grupo controle apresentaram de 0 a 4 pontos em pelo menos um dos itens questionados. CONCLUSÕES - Apesar de a maioria dos pacientes apresentar atitudes e sentimentos desencadeados pela acne, não se demonstrou associação estatisticamente significativa entre essa dermatose e baixo nível de bem-estar.BACKGROUND - Psychiatric comorbidity is observed in 40% of adult dermatological patients. Acne vulgaris, in particular, is in the interest of psychodermatology because of its psychological and social stigmas. OBJECTIVE - To establish the relation between acne and the state of well-being. METHODS - This consisted of a case-control study with data collected from the World Health Organization Well-being Index, through interviews with two groups of 50 medical students, one with and other without acne. RESULTS - It was verified that 26% of the students from the case group and 24% from the control group presented from 0 to 4 points in at least one item. CONCLUSIONS - Although the majority of the patients presented attitudes and feelings related to acne, a statistically significant association between this dermatosis and low level of well-being was not demonstrated.

  4. Acne

    OpenAIRE

    Emel Güngör

    2012-01-01

    Acne is a chronic disorder of pilosebaceous unit clinically characterized by comedones, papules, pustules, nodules and scarring. It affects almost 85% of young people between 12-24 years of age. Four main pathophysiologic factors that influence the development of acne are; increased sebum secretion, abnormal follicular desquamation, P. acnes colonization of the follicle and inflammation. The treatment of acne includes; topical retinoids, topical antimicrobial agents, systemic antibiotics, hor...

  5. Acne

    Science.gov (United States)

    ... Acne? (in Chinese 繁體中文 ) What Is Acne? (in Korean 한국어 ) What Is Acne? (in Vietnamese bằng tiếng ... of diseases and conditions. NIH RePORTER is an electronic tool that allows users to search a repository ...

  6. Acne

    Directory of Open Access Journals (Sweden)

    Emel Güngör

    2012-12-01

    Full Text Available Acne is a chronic disorder of pilosebaceous unit clinically characterized by comedones, papules, pustules, nodules and scarring. It affects almost 85% of young people between 12-24 years of age. Four main pathophysiologic factors that influence the development of acne are; increased sebum secretion, abnormal follicular desquamation, P. acnes colonization of the follicle and inflammation. The treatment of acne includes; topical retinoids, topical antimicrobial agents, systemic antibiotics, hormonal therapy and oral isotretinoin. Topical retinoids should be used as the first choice in comedonal acne, in combination with topical and/or systemic antimicrobials for mild to moderate inflammatory acne and as maintenance therapy once clearance has been achieved. Topical and systemic antibiotics which are used to treat moderate inflammatory acne should not be used as monotherapy but combined with topical benzoyl peroxide or topical retinoids and should be stopped as soon as possible. Hormonal therapy is an excellent choice for women, especially if oral contraception is desired. It may also be used for female patients with severe seborrhea, late onset acne and with proven hyperandrogenism. Oral isotretinoin targets all pathophysiologic factors in acne and is the mainstay of therapy for severe acne. It has to be kept in mind that the management of acne and compliance of the patient to the treatment can be enhanced by a number of general strategies such as education about acne and treatment, skin care, diet and adjuvant procedures.

  7. Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris

    Directory of Open Access Journals (Sweden)

    Yusuf Yildirim

    2014-01-01

    Full Text Available Purpose. We report the effect of isotretinoin on corneal topography, corneal thickness, and biomechanical parameters in patients with acne vulgaris. Method. Fifty-four eyes of 54 patients who received oral isotretinoin for treatment of acne vulgaris were evaluated. All patients underwent a corneal topographical evaluation with a Scheimpflug camera combined with Placido-disk (Sirius, ultrasonic pachymetry measurements, and corneal biomechanical evaluation with an ocular response analyzer at baseline, in the 1st, 3rd, and 6th months of treatment, and 6 months after isotretinoin discontinuation. Results. The thinnest corneal thickness measured with Sirius differed significantly in the 1st, 3rd, and 6th months compared with the baseline measurement; there was no significant change in ultrasonic central corneal thickness measurements and biomechanical parameters (corneal hysteresis and corneal resistance factor throughout the study. Average simulated keratometry and surface asymmetry index increased significantly only in the first month of treatment according to the baseline. All changes disappeared 6 months after the end of treatment. Conclusion. Basal tear secretion and corneal morphologic properties were significantly influenced during the systemic isotretinoin treatment and the changes were reversible after discontinuation. No statistical important biomechanical differences were found to be induced by isotretinoin.

  8. Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience.

    Science.gov (United States)

    Kim, Grace K; Del Rosso, James Q

    2012-03-01

    Oral spironolactone has been used for over two decades in the dermatological setting. Although it is not generally considered a primary option in the management of female patients with acne vulgaris, the increase in office visits by post-teenage women with acne vulgaris has recently placed a spotlight on the use of this agent in this subgroup of patients. This article reviews the literature focusing on the use of oral spironolactone in this subset of women with acne vulgaris, including discussions of the recommended starting dose, expected response time, adjustments in therapy, potential adverse effects, and patient monitoring. PMID:22468178

  9. Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris.

    Directory of Open Access Journals (Sweden)

    Yipeng Wang

    Full Text Available Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and it is the first identified cathelicidin antimicrobial peptide in reptiles. In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium acnes. Its minimal inhibitory concentration against two strains of P. acnes was 4.7 µg/ml. Cathelicidin-BF also effectively killed other microorganisms including Staphylococcus epidermidis, which was possible pathogen for acne vulgaris. Cathelicidin-BF significantly inhibited pro-inflammatory factors secretion in human monocytic cells and P. acnes-induced O2.- production of human HaCaT keratinocyte cells. Observed by scanning electron microscopy, the surfaces of the treated pathogens underwent obvious morphological changes compared with the untreated controls, suggesting that this antimicrobial peptide exerts its action by disrupting membranes of microorganisms. The efficacy of cathelicidin-BF gel topical administering was evaluated in experimental mice skin colonization model. In vivo anti-inflammatory effects of cathelicidin-BF were confirmed by relieving P. acnes-induced mice ear swelling and granulomatous inflammation. The anti-inflammatory effects combined with potent antimicrobial activities and O2.- production inhibition activities of cathelicidin-BF indicate its potential as a novel therapeutic option for acne vulgaris.

  10. Intense pulsed light versus photodynamic therapy using liposomal methylene blue gel for the treatment of truncal acne vulgaris: a comparative randomized split body study.

    Science.gov (United States)

    Moftah, Nayera Hassan; Ibrahim, Shady Mahmoud; Wahba, Nadine Hassan

    2016-05-01

    Acne vulgaris is an extremely common skin condition. It often leads to negative psychological consequences. Photodynamic therapy (PDT) using intense pulsed light has been introduced for effective treatment of acne. The objective was to study the effect of PDT in truncal acne vulgaris using liposomal methylene blue (LMB) versus IPL alone. Thirty-five patients with varying degrees of acne were treated with topical 0.1 % LMB hydrogel applied on the randomly selected one side of the back, and after 60 min the entire back was exposed to IPL. The procedure was done once weekly for three sessions and patients were re-evaluated 1 month after the third session by two independent dermatologists. Acne severity was graded using the Burton scale. Patient satisfaction using Cardiff Acne Disability Index (CADI) was recorded before and after treatment. On LMB-pretreated side, inflammatory acne lesion counts were significantly decreased by 56.40 % compared with 34.06 % on IPL alone. Marked improvement was seen on LMB-pretreated side in 11.5 % of patients compared with 2.8 % on IPL alone. There was a correlation between CADI score and overall improvement. Our study concluded that LMB-IPL is more effective than IPL alone, safe with tolerable pain in the treatment of acne vulgaris on the back. LMB-IPL is more effective than IPL alone, safe with tolerable pain in the treatment of acne vulgaris on the back.

  11. Acne

    OpenAIRE

    Krafchik, Bernice R

    1999-01-01

    Acne is a disease that primarily affects adolescents but it may also be seen in neonates, children and adults. The main areas of involvement are the face, chest and back. Many individuals with acne are embarrassed by their condition, and even refuse to go to school and become socially withdrawn. Early treatment can prevent the devastating physical and emotional sequelae of acne. There are numerous effective therapies, and it is not necessary for patients to go through the trauma that plagued ...

  12. Acne

    Science.gov (United States)

    ... pills are used along with a drug called spironolactone to treat acne in adult females. This medication lowers levels of ... include irregular menstruation, breast tenderness, headache and fatigue. Spironolactone is ... used for acne scarring? If you have scarring, your dermatologist may ...

  13. Decreased peroxisome proliferator-activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris.

    Science.gov (United States)

    Dozsa, A; Mihaly, J; Dezso, B; Csizmadia, E; Keresztessy, T; Marko, L; Rühl, R; Remenyik, E; Nagy, L

    2016-07-01

    Little is known about the altered lipid metabolism-related transcriptional events occuring in sebaceous glands of patients with acne vulgaris. Peroxisome proliferator-activated receptor (PPAR)γ, a lipid-activated transcription factor, is implicated in differentiation and lipid metabolism of sebocytes. We have observed that PPARγ and its target genes, ADRP (adipose differentiation related protein) and PGAR (PPARγ angioprotein related protein) are expressed at lower levels in sebocytes from patients with acne than in those from healthy controls (HCs) Furthermore, endogenous PPARγ activator lipids such as arachidonic acid-derived keto-metabolites (e.g. 5KETE, 12KETE) are increased in acne-involved and nonacne-involved skin of patients with acne, compared with skin from healthy individuals. Our findings highlight the possible anti-inflammatory role of endogenous ligand-activated PPARγ signaling in human sebocyte biology, and suggest that modulating PPARγ- expression and thereby signaling might be a promising strategy for the clinical management of acne vulgaris.

  14. Topical erythromycin-zinc acetate complex lotion versus topical erythromycin gel in treatment of mild to moderate acne vulgaris

    Directory of Open Access Journals (Sweden)

    Hayder R. Al-Hamamy

    2014-10-01

    Full Text Available Introduction: Topical antibiotics are the main step in the treatment of mild to moderate acne vulgaris. Erythromycin is one of the effective topical therapies for this disease. Zinc sulfate 5% solution was reported to be effective in treatment of acne vulgaris and rosacea. Aim: To compare the effectiveness and side effects of topical erythromycin in combination with zinc and erythromycin alone in treatment of mild to moderate acne vulgaris. Material and Methods: This single, blind, therapeutic, comparative study was done in the Department of Dermatology – Baghdad Teaching Hospital, Baghdad, Iraq; from May 2012 – August 2013.Scoring of acne was carried out and the patients were examined every two weeks for 10 weeks of treatment. One month after stopping drugs, patients were evaluated for drug complications and disease recurrence. Eighty patients fulfilling enrollment criteria were included in this study. Patients were divided into two groups: Group A (40 patients treated twice daily with topical erythromycin-zinc complex lotion and Group B (40 patients treated twice daily with topical 2% erythromycin gel. Results: Both topical erythromycin-zinc lotion and erythromycin gel were statistically an effective therapy starting after 6 weeks treatment and up to 4 weeks after stopping treatment. Erythromycin-zinc lotion was more effective and act earlier than erythromycin gel starting from 4 weeks of therapy till the end of treatment (after 10 week and even after 4 weeks after stopping the treatment (p value <0.0001. Conclusions: Erythromycin-zinc complex lotion was an effective and well tolerated topical therapy for mild to moderate inflammatory acne vulgaris and was more effective than erythromycin gel alone.

  15. The efficacy, safety and tolerability of adapalene versus benzoyl peroxide in the treatment of mild acne vulgaris; a randomized trial.

    Science.gov (United States)

    Babaeinejad, S H; Fouladi, R F

    2013-09-01

    Topical treatments, such as adapalene and benzoyl peroxide (BPO), are popular in mild-to-moderate acne vulgaris. This study aimed to compare the efficacy, safety and tolerability of adapalene and BPO in mild acne vulgaris. In this single-center, randomized, double-blind, clinical trial, 60 patients with mild acne vulgaris received either topical adapalene 0.1% gel or topical BPO 2.5% gel on their face once daily for two months. The changes of acne lesion count (efficacy), any adverse effect (safety), and the patients' overall satisfaction (tolerability) were compared after 3 months of follow-up. In both groups the mean number of noninflammatory, inflammatory and total lesions decreased significantly from baseline (10.77±5.54, 9.73±5.09, and 20.50±7.54, respectively in adapalene group; 11.50±5.92, 8.43±5.45, and 19.93±9.01, respectively in BPO group) to the third month (1.70±1.68, 0.33±0.66, and 0.50±0.78, respectively in adapalene group; 4.23±4.14, 0.33±0.71, and 4.13±4.44, respectively in BPO group; PBPO receivers only at first month (P=0.001), the mean number of noninflammatory and total lesions was significantly lower in adapalene group at second (P= 0.04 and 0.03, respectively) and third (P=0.02 and BPO group, P=0.54). The patients' overall satisfaction was good-excellent in 93.3% of adapalene receivers vs. 73.3% in BPO group (P=0.08). Both topical adapalene 0.1% and BPO 2.5% gels seem safe and effective in mild acne vulgaris, with a marginal tendency toward the former.

  16. The efficacy, safety, and tolerability of adapalene versus benzoyl peroxide in the treatment of mild acne vulgaris: a randomized trial.

    Science.gov (United States)

    Babaeinejad, S H; Fouladi, R F

    2013-07-01

    Topical treatments, such as adapalene and benzoyl peroxide (BPO), are popular in mild-to-moderate acne vulgaris. This study aimed to compare the efficacy, safety and tolerability of adapalene and BPO in mild acne vulgaris. In this single-center, randomized, double-blind, clinical trial, 60 patients with mild acne vulgaris received either topical adapalene 0.1% gel or topical BPO 2.5% gel on their face once daily for two months. The changes of acne lesion count (efficacy), any adverse effect (safety), and the patients' overall satisfaction (tolerability) were compared after 3 months of follow-up. In both groups the mean number of noninflammatory, inflammatory and total lesions decreased significantly from baseline (10.77±5.54, 9.73±5.09, and 20.50±7.54, respectively in adapalene group; 11.50±5.92, 8.43±5.45, and 19.93±9.01, respectively in BPO group) to the third month (1.70±1.68, 0.33±0.66, and 0.50±0.78, respectively in adapalene group; 4.23±4.14, 0.33±0.71, and 4.13±4.44, respectively in BPO group; PBPO receivers only at first month (P =0.001), the mean number of noninflammatory and total lesions was significantly lower in adapalene group at second (P = 0.04 and 0.03, respectively) and third (P =0.02 and BPO group, p=0.54). The patients' overall satisfaction was good to excellent in 93.3% of adapalene receivers vs. 73.3% in BPO group (P=0.08). Both topical adapalene 0.1% and BPO 2.5% gels seem safe and effective in mild acne vulgaris, with a marginal tendency toward the former.

  17. Clinical Observation in 86 Cases of Acne Vulgaris Treated with Compound Oldenlandis Mixture

    Institute of Scientific and Technical Information of China (English)

    刘瓦林; 沈冬; 宋坪; 许铣

    2003-01-01

    86 cases of acne vulgaris were treated with Fu Fang She She Cao He Ji (复方蛇舌草合剂 CompoundPrepared from Chinese Angelica and Flavescent Sophora Root) as the controls, to observe the therapeuticeffect of the former. The results showed that the cure plus markedly effective rate was 73.26% in thetreatment group, and 47.06% in the control group, with a significant difference in the cure plus markedlyeffective rate between the two groups (P<0.01), and also in the total effective rate between the two groupssignificant (P<0.05). It may be concluded that the Compound Oldenlandis Mixture is a better agent for theillness.

  18. Immunohistochemical expression of interleukin 8 in skin biopsies from patients with inflammatory acne vulgaris

    Directory of Open Access Journals (Sweden)

    El Maged Rabee A

    2007-01-01

    Full Text Available Abstract Background This study was conducted to evaluate the immunohistochemical (IHC expression of interleukin 8 (IL-8 in skin biopsies of inflammatory acne vulgaris (IAV in an attempt to understand the disease pathogenesis. Materials and methods A total of 58 biopsies, 29 from lesional IAV and 29 normal non lesional sites were immunostained for IL-8. The intensity of staining was evaluated in the epidermis and dermis and was scored as mild, moderate and severe. The expression was correlated with the clinical grade, disease course and histological changes. Results IL-8 immunoreactivity was expressed in lesional IAV compared to non lesional skin biopsies (p Conclusion We were able to demonstrate altered immunoreactivity of IL-8 in IAV compared to normal skin. Targeted therapy to block IL-8 production may hold promise in limiting the deleterious effects of IL-8-mediated inflammatory response and angiogenesis.

  19. Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris.

    Science.gov (United States)

    Akarsu, Sevgi; Fetil, Emel; Yücel, Filiz; Gül, Eylem; Güneş, Ali T

    2012-05-01

    Clindamycin phosphate (CDP), benzoyl peroxide (BPO) and salicylic acid (SA) are known to be effective acne therapy agents depending on their anti-inflammatory and comedolytic properties. The purpose of this study was to investigate the efficacy and tolerability of the addition of SA treatment to CDP and BPO (SA and CDP + BPO) and compare it with CDP + BPO in patients with mild to moderate facial acne vulgaris. Forty-nine patients were enrolled in a 12 week prospective, single-blind, randomized, comparative clinical study. Efficacy was assessed by lesion counts, global improvement, quality of life index and measurements of skin barrier functions. Local side effects were also evaluated. Both combinations were effective in reducing total lesion (TL), inflammatory lesion (IL) and non-inflammatory lesion (NIL) counts. There were statistically significant differences between treatment groups for reductions in NIL counts beyond 2 weeks, IL counts and TL counts throughout the all study weeks, and global improvement scores evaluated by patients and investigator at the end of the study in favor of SA and CDP + BPO treatment when compared to CDP + BPO treatment. Both combinations significantly decreased stratum corneum hydration, although skin sebum values decreased with SA and CDP + BPO treatment. These combinations were also well tolerated except significantly higher frequency of mild to moderate transient dryness in patients applied SA and CDP + BPO. The addition of SA to CDP + BPO treatment demonstrated significantly better and faster results in terms of reductions in acne lesion counts and well tolerated except for higher frequency of mild to moderate transient dryness.

  20. Comparison of Safety and Efficacy of Oral Azithromycin-Topical Adapalene Versus Oral Doxycycline-Topical Adapalene in the Treatment of Acne Vulgaris and Determination of the Effects of These Treatments on Patients’ Quality of Life

    OpenAIRE

    Serap Kayhan; İlham Sabuncu; Zeynep Nurhan Saraçoğlu; Ayşe Esra Koku Aksu; Mustafa Tozun

    2012-01-01

    Background and Design: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Oral antibiotics and topical retinoids are effective in the treatment of acne.Materials and Methods: In this study, 60 patients with moderate acne vulgaris were evaluated; the patients were randomized into two equal groups. The groups were matched with respect to age, gender and clinical severity of acne. The patients in group 1 received oral azithromycin (500 mg daily on 3 consecutive days per w...

  1. Solid Lipid Nanoparticles Loaded with Retinoic Acid and Lauric Acid as an Alternative for Topical Treatment of Acne Vulgaris.

    Science.gov (United States)

    Silva, Elton Luiz; Carneiro, Guilherme; De Araújo, Lidiane Advíncula; Trindade, Mariana de Jesus Vaz; Yoshida, Maria Irene; Oréfice, Rodrigo Lambert; Farias, Luis de Macêdo; De Carvalho, Maria Auxiliadora Roque; Dos Santos, Simone Gonçalves; Goulart, Gisele Assis Castro; Alves, Ricardo José; Ferreira, Lucas Antônio Miranda

    2015-01-01

    Topical therapy is the first choice for the treatment of mild to moderate acne and all-trans retinoic acid is one of the most used drugs. The combination of retinoids and antimicrobials is an innovative approach for acne therapy. Recently, lauric acid, a saturated fatty acid, has shown strong antimicrobial activity against Propionibacterium acnes. However, topical application of retinoic acid is followed by high incidence of side-effects, including erythema and irritation. Solid lipid nanoparticles represent an alternative to overcome these side-effects. This work aims to develop solid lipid nanoparticles loaded with retinoic acid and lauric acid and evaluate their antibacterial activity. The influence of lipophilic stearylamine on the characteristics of solid lipid nanoparticles was investigated. Solid lipid nanoparticles were characterized for size, zeta potential, encapsulation efficiency, differential scanning calorimetry and X-ray diffraction. The in vitro inhibitory activity of retinoic acid-lauric acid-loaded solid lipid nanoparticles was evaluated against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis. High encapsulation efficiency was obtained at initial time (94 ± 7% and 100 ± 4% for retinoic acid and lauric acid, respectively) and it was demonstrated that lauric acid-loaded-solid lipid nanoparticles provided the incorporation of retinoic acid. However, the presence of stearylamine is necessary to ensure stability of encapsulation. Moreover, retinoic acid-lauric acid-loaded solid lipid nanoparticles showed growth inhibitory activity against Staphylococcus epidermidis, Propionibacterium acnes and Staphylococcus aureus, representing an interesting alternative for the topical therapy of acne vulgaris. PMID:26328443

  2. The efficacy and safety of amoxicillin, trimethoprim-sulfamethoxazole, and spironolactone for treatment-resistant acne vulgaris.

    Science.gov (United States)

    Turowski, Cheryl Bansal; James, William D

    2007-01-01

    In situations where acne has proved resistant to other systemic agents or they are not indicated and isotretinoin is not desired by patients, the authors find amoxicillin, TMP-SMX, and spironolactone, alone or in combination, useful alternatives. In women who have acne, spironolactone can be used, and in patients who have sulfa allergy, amoxicillin can be used. It is important to continue alternate topical therapy along with these interventions to augment the improvement and to assist in the eventual discontinuance of oral medication. All of the authors' patients were using topical therapy concomitantly and, although this may have contributed to improvement, the authors believe the addition of amoxicillin, TMP-SMX, or spironolactone contributes to the majority of improvement. Tetrospective chart analysis provides supportive data for amoxicillin, TMP-SMX, and spironolactone in the treatment of refractory acne vulgaris. PMID:18159900

  3. Antiandrogenic Therapy with Ciproterone Acetate in Female Patients Who Suffer from Both Androgenetic Alopecia and Acne Vulgaris

    OpenAIRE

    2014-01-01

    Background. Androgenetic Alopecia in Women (AGA) occurs due to an underlying susceptibility of hair follicles to androgenic miniaturization, caused by androgens. Clinically, AGA is characterized by progressive hair loss, with a marked hair thinning in the fronto-parietal area so that the scalp can be easily seen. Acne vulgaris is androgen-dependent and often affects the skin that has an increased number of oil glands: face, back and chest. Although the sebaceous glands are present on the scal...

  4. Analysis of clinical efficacy, side effects, and laboratory changes among patients with acne vulgaris receiving single versus twice daily dose of oral isotretinoin.

    Science.gov (United States)

    Ahmad, Hesham M

    2015-01-01

    Acne vulgaris is a debilitating disorder and requires proper treatment. This work evaluates the clinical efficacy, side effects, and laboratory changes of serum lipids and liver function during oral isotretinoin therapy for acne vulgaris, comparing single versus twice daily dose. Fifty-eight patients with acne vulgaris were included and randomized into group I (26 patients), who received once daily dose, and group II (32 patients), who received twice daily dose of oral isotretinoin. Global acne scoring system was used to evaluate acne severity and post-treatment improvement. Both regimens resulted in highly significant clinical improvement of acne with no significant difference. However, side effects were significantly more common among patients of group I. Both regimens caused mild rise of serum cholesterol, alanine transaminase (ALT), and aspartate aminotransferase (AST) with more prominent rise of triglycerides especially with twice daily dose. Oral isotretinoin is a very effective treatment for acne vulgaris with no statistically significant difference in clinical efficacy between once and twice daily doses. However, dividing dose to twice per day might cause fewer incidence of side effects without reducing clinical efficacy. The drug causes mild clinically insignificant rise of serum cholesterol, triglycerides, AST, and ALT.

  5. High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study

    Directory of Open Access Journals (Sweden)

    Ismail Noor

    2012-08-01

    Full Text Available Abstract Background The role of dietary factors in the pathophysiology of acne vulgaris is highly controversial. Hence, the aim of this study was to determine the association between dietary factors and acne vulgaris among Malaysian young adults. Methods A case–control study was conducted among 44 acne vulgaris patients and 44 controls aged 18 to 30 years from October 2010 to January 2011. Comprehensive acne severity scale (CASS was used to determine acne severity. A questionnaire comprising items enquiring into the respondent’s family history and dietary patterns was distributed. Subjects were asked to record their food intake on two weekdays and one day on a weekend in a three day food diary. Anthropometric measurements including body weight, height and body fat percentage were taken. Acne severity was assessed by a dermatologist. Results Cases had a significantly higher dietary glycemic load (175 ± 35 compared to controls (122 ± 28 (p  0.05. Conclusions Glycemic load diet and frequencies of milk and ice cream intake were positively associated with acne vulgaris.

  6. Treatment of inflammatory facial acne vulgaris in Chinese patients with the 1450-nm diode laser: a pilot study

    Science.gov (United States)

    Liu, Huaxu; Dang, Yongyan; Wang, Zhan; Ma, Li; Ren, Qiushi

    2007-02-01

    The 1450-nm diode laser has been found to be effective for the treatment of inflammatory acne in USA, Europe and Japan. However, there is no report on its efficacy in Chinese acne vulgaris patients. We conduct this pilot study to evaluate the efficacy and safety of the 1450-nm diode laser in the treatment of inflammatory facial acne vulgaris in Chinese patients. Nineteen patients with inflammatory facial acne were treated with the 1450-nm diode laser at 4- to 6-week intervals. Clinical photographs and lesion counts were obtained at baseline and after each treatment. Subjective evaluation of response to treatment and pain was assessed using a questionnaire. In our study, clinical improvement was seen in all patients and was generally dramatic. Lesion counts decreased 34% after one treatment (ptreatments (ptreatments (ptreatment-related pain was comparatively hard to be tolerated in Chinese patitents, and the other main adverse effect was the hyper-pigmentation after treatments (36.84%, 7/19).

  7. A randomized controlled study for the treatment of acne vulgaris using high-intensity 414 nm solid state diode arrays.

    Science.gov (United States)

    Ash, Caerwyn; Harrison, Anna; Drew, Samantha; Whittall, Rebecca

    2015-01-01

    The treatment of acne vulgaris poses a challenge to the dermatologist, and the disease causes emotional anxiety for the patient. The treatment of acne vulgaris may be well-suited to home-use applications, where sufferers may be too embarrassed to seek medical treatment. This randomized controlled study is designed to quantify the effectiveness of using a blue light device in a therapy combined with proprietary creams, in the investigation of a self-treatment regimen. A total of 41 adults with mild-to-moderate facial inflammatory acne were recruited. The subjects were randomly assigned to combination blue light therapy (n = 26) or control (n = 15). Photography was used for qualitative assessment of lesion counts, at weeks 1, 2, 4, 8, and 12. All subjects in the treatment cohort achieved a reduction in their inflammatory lesion counts after 12 weeks. The mean inflammatory lesion counts reduced by 50.02% in the treatment cohort, and increased by 2.45% in the control cohort. The reduction in inflammatory lesions was typically observable at week-3, and maximal between weeks 8 and 12. The treatment is free of pain and side-effects. The blue light device offers a valuable alternative to antibiotics and potentially irritating topical treatments. Blue light phototherapy, using a narrow-band LED light source, appears to be a safe and effective additional therapy for mild to moderate acne.

  8. Effect on serum sex hormone levels, immune index of benzoyl peroxide combining with Hirudoid on acne vulgaris

    Institute of Scientific and Technical Information of China (English)

    Lin Li; Jie Sun; The authorsi-heng Yu; Yun-hao Hu

    2015-01-01

    Objective:To observe the effect on serum sex hormone levels, immune index of benzoyl peroxide combining with Hirudoid on acne vulgaris.Methods: 185 patients with acne vulgaris included in the study the authorsre divided into the observation group (85 cases) and the control group (80 cases), the observation group was given the treatment of benzoyl peroxide combining with Hirudoid, and the control group was treated with benzoyl peroxide. To observe the change of hormones (T, FSH, LH, E2) and immune indexes (IgG, IgA, IgM, C3, C4, IL-2, sIL-2R) after 1 month of treatment.Results: After treatment, IgG, C3, C4, IL-2 of the observation group the authorsre significantly different than those before trteatment(P0.05); After treatment, IgG, C3, C4, IL-2 level of two groups the authorsre statistically significant (P<0.05).Where the authorsre no significant difference on sex hormones betthe authorsen the two groups before and after treatment.Conclusion:Benzoyl peroxide combining with Hirudoid has certain effects on immune function for the patients with acne vulgaris, and may be related to therapeutic effect, but no obvious effect on sex hormone.

  9. Acne

    Science.gov (United States)

    ... skin. Testing is not needed in most cases. Bacterial culture may be performed to rule out infection if large pus bumps persist. Treatment SELF-CARE Steps you can take to help your acne : Clean your skin gently with a mild, nondrying soap (such as Dove, Neutrogena, Cetaphil, CeraVe, or Basics). ...

  10. Effect of Automated Online Counseling on Clinical Outcomes and Quality of Life Among Adolescents With Acne Vulgaris

    Science.gov (United States)

    Tuong, William; Wang, Audrey S.; Armstrong, April W.

    2016-01-01

    IMPORTANCE Effective patient education is necessary for treating patients with acne vulgaris. Automated online counseling simulates face-to-face encounters and may be a useful tool to deliver education. OBJECTIVE To compare the effectiveness of a standard educational website with that of an automated-counseling website in improving clinical outcomes and quality of life among adolescents with acne. DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial conducted between March 27, 2014, and June 27, 2014, including a 12-week follow-up in a local inner-city high school. Ninety-eight students aged at least 13 years with mild to moderate acne were eligible for participation. A per-protocol analysis of the evaluable population was conducted on clinical outcome data. INTERVENTIONS Participants viewed either a standard educational website or an automated-counseling website. MAIN OUTCOMES AND MEASURES The primary outcome was the total acne lesion count. Secondary measures included the Children’s Dermatology Life Quality Index (CDLQI) scores and general skin care behavior. RESULTS Forty-nine participants were randomized to each group. At baseline, the mean (SD) total acne lesion count was not significantly different between the standard-website group and the automated-counseling–website group (21.33 [10.81] vs 25.33 [12.45]; P = .10). Improvement in the mean (SD) acne lesion count was not significantly different between the standard-website group and the automated-counseling–website group (0.20 [9.26] vs 3.90 [12.19]; P = .10). The mean (SD) improvement in CDLQI score for the standard-website group was not significantly different from that of the automated-counseling–website group (0.17 [2.64] vs 0.39 [2.94]; P = .71). After 12 weeks, a greater proportion of participants in the automated-counseling–website group maintained or adopted a recommended anti-acne skin care routine compared with the standard-website group (43% vs 22%; P = .03). CONCLUSIONS AND

  11. [DRUG-INDUCED LUPUS CAUSED BY LONG TERM MINOCYCLINE TREATMENT FOR ACNE VULGARIS].

    Science.gov (United States)

    Hanai, Shunichiro; Sato, Takeo; Takeda, Koichi; Nagatani, Katsuya; Iwamoto, Masahiro; Minota, Seiji

    2015-09-01

    An 18-year-old Japanese girl had received oral minocycline 200mg daily for treatment of acne vulgaris since 16 years old. She had a fever three months before admission, followed by joint pains in her knees, elbows and several proximal interphalangeal joints one month before admission. She was referred to our hospital because of a high serum level of anti-DNA antibody. She had already discontinued oral minocycline five weeks before admission, because she missed her medication refilled. On admission, the arthralgia and fever spontaneously resolved, and there were no laboratory evidence of hypocomplementemia and cytopenia. She had neither erythema nor internal organ involvements. Because her symptoms subsided spontaneously after the cessation of minocycline, she was considered to have drug-induced lupus. Both the arthralgia and fever did not relapse, and anti-ds DNA antibody returned to normal during a follow-up period without treatment. There are few reports of drug-induced lupus caused by minocycline in Japan. This case highlights the importance of considering minocycline-induced lupus.

  12. A single-blinded, randomized, controlled clinical trial evaluating the effect of face washing on acne vulgaris.

    Science.gov (United States)

    Choi, Joanna Mimi; Lew, Vincent K; Kimball, Alexa B

    2006-01-01

    Despite the common recommendation to wash the face twice daily with a mild cleanser, there is little published evidence to support the practice. Indeed, while the general public believes that cleaner skin will result in fewer blemishes, dermatologists often warn that overwashing and scrubbing can exacerbate the condition. To clarify the effect of frequency of face washing on acne vulgaris, we designed a single-blinded, randomized, controlled clinical trial to be conducted on males with mild to moderate acne vulgaris. Subjects washed their faces twice daily for 2 weeks with a standard mild cleanser before being randomized to one of three study arms, in which face washing was to be done once, twice, or four times a day for 6 weeks. At the end of the study no statistically significant differences were noted between groups. However, significant improvements in both open comedones and total noninflammatory lesions were observed in the group washing twice a day. Worsening of acne condition was observed in the study group washing once a day, with significant increases in erythema, papules, and total inflammatory lesions. We concluded that slight support exists, both in terms of efficacy and convenience, for the recommendation to wash the face twice daily with a mild cleanser. However, excessive face washing may not be as culpable as previously thought. PMID:17014635

  13. Demographic Features, Beliefs And Socio–Psychological Impact Of Acne Vulgaris Among Its Sufferers In Two Towns In Nigeria

    Directory of Open Access Journals (Sweden)

    Ikaraoha CI

    2005-05-01

    Full Text Available There is paucity of reports in the demographic knowledge, belief and socio-psychological impact of acne vulgaris sufferers towards the disorder in a black population. This is the first study from Nigeria designed to address this issue. A total of 174 facial acne sufferers completed a self-administered questionnaire, which contained several items mentioning different areas in their belief, knowledge, perception, severity, socio-psychological impact and medication attention. The findings were discussed and compared to those of the Caucasians. The occurrence of the disorder was higher in females (65.0% compared to the males (35.0%. About 54.0% of the female subjects indicated increase in severity of the disorder during their pre-menstrual period. Also 64.9% of acne sufferers indicated increase in severity during the rainy season, while 93.1% of the population implicated stress to perpetuate the severity of the disorder. Most (75.7% of the acne sufferers believed that it is caused by oily diet, 40.8% thought that it is hereditary, while barely 5.2% had at sometime sought doctor's attention. Non- prescription products used by acne sufferers were cleansers and cream/lotions. Psychological abnormalities experienced by the sufferers included social inhibition, depression and anxiety. Pain and discomfort are the psychosomatic symptoms. No major differences were found in the beliefs, misconception and socio-psychological impact of acne sufferers in a black population (Nigeria compared to the Caucasians. There is need to improve the understanding of the disorder in Nigeria through health education programmes

  14. Serum and tissue contents of copper, calcium, iron and magnesium elements in cases of acne vulgaris after zinc therapy

    International Nuclear Information System (INIS)

    The effect of zinc therapy on some trace elements contents in serum and skin was studied in normal group (forty) and patients group with acne vulgaris (26 males and 14 females) with age ranged between 14-30 year. They were under medical treatment with 330 mg oral zinc sulfate for 12 weeks. Highly significant decreases in both serum and tissue contents of copper and calcium were detected, as well as, highly significant decrease in the serum content of magnesium was recorded. The serum content of iron was highly significantly increased and that for tissue content was slightly significantly increased. It could be concluded that zinc therapy could be valuable through modulation of copper. calcium, iron and magnesium in acne patients

  15. Successful treatment of mild to moderate acne vulgaris with Dr Michaels® (also branded as Zitinex®) topical products family: a clinical trial.

    Science.gov (United States)

    Wollina, U; Tirant, M; Bayer, P; Coburn, M; Anderson, P; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Walmsley, S; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Acne vulgaris is an epidemic inflammatory skin disease of multi-factorial origin, frequently seen in adolescents and often persisting or occurring through to adulthood. Acne vulgaris is a nearly universal skin disease afflicting 79-95% of the adolescent population in westernized societies and is a significant cause of psychological morbidity in affected patients. Despite the various treatment options available for acne, there is still a need for a safe and effective option. The aim of the study was to investigate the efficacy and tolerability of Dr Michaels® (Zitinex®) product family in the treatment of papulo-pustular acne. 25 patients (17 female/8 male), aged 15-22, with a mild to moderate papulo-pustular acne, localized on the face and on the trunk, were included in this study. None of the patients had used any other kind of treatment in the 3 months prior to commencing this study. All of the patients were treated with Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, a cream, PSC 200 and PSC 900 oral supplements. Application time of Dr Michaels® (Zitinex®) products was 12 weeks. The treatment was been evaluated clinically at 0, 4, 8 and 12 weeks. All of the patients showed an improvement in all parameters of their acne (comedones, papules, pustules, hyperpigmentation and scars). The acne lesions and erythema had mostly resolved. The hyperpigmentation and pitted scarring had significantly reduced also, with the skin appearing smoother. The treatment was well tolerated and no side effects have been described. Our study demonstrates that the Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, cream and oral supplements PSC 200 and PSC 900 are an effective therapeutic option for the treatment of moderately severe acne vulgaris. Moreover, it highlights the safety profile of the Dr Michaels® (Zitinex®) product family in a case of acne compared to traditional first-line treatments. PMID:27498658

  16. Successful treatment of mild to moderate acne vulgaris with Dr Michaels® (also branded as Zitinex®) topical products family: a clinical trial.

    Science.gov (United States)

    Wollina, U; Tirant, M; Bayer, P; Coburn, M; Anderson, P; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Walmsley, S; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Acne vulgaris is an epidemic inflammatory skin disease of multi-factorial origin, frequently seen in adolescents and often persisting or occurring through to adulthood. Acne vulgaris is a nearly universal skin disease afflicting 79-95% of the adolescent population in westernized societies and is a significant cause of psychological morbidity in affected patients. Despite the various treatment options available for acne, there is still a need for a safe and effective option. The aim of the study was to investigate the efficacy and tolerability of Dr Michaels® (Zitinex®) product family in the treatment of papulo-pustular acne. 25 patients (17 female/8 male), aged 15-22, with a mild to moderate papulo-pustular acne, localized on the face and on the trunk, were included in this study. None of the patients had used any other kind of treatment in the 3 months prior to commencing this study. All of the patients were treated with Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, a cream, PSC 200 and PSC 900 oral supplements. Application time of Dr Michaels® (Zitinex®) products was 12 weeks. The treatment was been evaluated clinically at 0, 4, 8 and 12 weeks. All of the patients showed an improvement in all parameters of their acne (comedones, papules, pustules, hyperpigmentation and scars). The acne lesions and erythema had mostly resolved. The hyperpigmentation and pitted scarring had significantly reduced also, with the skin appearing smoother. The treatment was well tolerated and no side effects have been described. Our study demonstrates that the Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, cream and oral supplements PSC 200 and PSC 900 are an effective therapeutic option for the treatment of moderately severe acne vulgaris. Moreover, it highlights the safety profile of the Dr Michaels® (Zitinex®) product family in a case of acne compared to traditional first-line treatments.

  17. Safety and efficacy of low-dose isotretinoin in the treatment of moderate to severe acne vulgaris

    Directory of Open Access Journals (Sweden)

    Parinitha K Rao

    2014-01-01

    Full Text Available Background: Isotretinoin is indicated for moderate to severe cases of acne which are unresponsive to conventional therapy. The classical recommended dose is 0.5 to 1.0 mg/kg/day. As the side effects are dose related, low-dose isotretinoin therapy for acne is an attractive option; however, but little data exists on the safety and efficacy of this strategy. Materials and Methods: In this prospective, non-comparative study, 50 participants, both male and female, having moderate to severe acne vulgaris were enrolled and treated with isotretinoin at a dose of 20 mg/day (approximately 0.3-0.4 mg/kg/day, for a period of 3 months. Participants were evaluated by means of clinical and laboratory investigations before starting isotretinoin. Investigations were repeated at the end of the first and third months following completion of treatment, and participants were followed up for 6 months to look for any relapse. Results: At the end of the treatment, very good results were observed in 90% of participants. Cheilitis was the most common among the side effects observed and was seen in 98% of the participants. One participant developed vitiligo as a side effect, which is a new finding, and has not reported in literature before. Elevated serum lipid levels were observed in 6% of the participants, and relapse occurred in 4% of the participants over a 6 month follow up period. Conclusion: Three months of treatment with low-dose isotretinoin (20 mg/day was found to be effective in the treatment of moderate to severe acne vulgaris, with a low incidence of serious side effects. This dose also was more economical than the higher doses.

  18. 红-蓝光联合治疗寻常痤疮的疗效%Clinical efficacy of combined blue and red phototherapy in treatment of acne vulgaris

    Institute of Scientific and Technical Information of China (English)

    蒋婷; 李军; 任军

    2010-01-01

    Objective Acne vulgaris remains a major problem in dermatological practice. Phototherapy for acne with blue and red light-emitting diode (LED) arrays has recently attracted attention.The aim of this study is to observe the clinical effect of the blue and red light combination phototherapy on acne. Methods 65 individuals were recruited: 25 females and 5 males. Patients underwent treatment of 20-25 minutes blue light and 5-10 minutes combined light treatment twice per week. Continuous irradiation for 4 weeks was as 1 session. Mild acne vulgaris was treated for 1 session, moderate and severe acne were treated for 1 or 2 sessions. Results After system treatment, the acne lesion was reduced apparently without side effect. The effective rate of mild acne vulgaris, moderate acne vulgaris and severe acne vulgris was 80 %, 89.4 % and 88.2 %, respectively. Conclusion The combination of blue and red light-emitting diode therapy for acne vulgaris is effective. This therapy is convenient without side effect, and it is a new preferable modality for the treatment of acne.%目的 探讨红-蓝光联合治疗寻常痤疮临床疗效.方法 对65例痤疮患者采用红-蓝光联合照射治疗,每位患者每次使用蓝光照射20~25 min,然后使用红-蓝光联合照射5~10 min,每周2次,连续照射4周为1个疗程.轻度痤疮患者治疗1个疗程,中、重度痤疮患者连续治疗1~2个疗程.结果 经过系统治疗后,所有患者痤疮皮损均有明显改善且无副作用,轻度痤疮有效率为80%,中度痤疮有效率为89.4%,重度痤疮有效率为88.2%.结论 应用红-蓝光联合治疗寻常痤疮是安全且有效的治疗方法.

  19. Impact of acne vulgaris on quality of life and self-esteem.

    Science.gov (United States)

    Hosthota, Abhineetha; Bondade, Swapna; Basavaraja, Vinay

    2016-08-01

    The psychological impact of acne is determined by various factors including age, sex, personality, grade of disease, scarring, and environmental and ethnic background. Apart from managing the clinical manifestations of acne, clinicians also have to deal with the psychological aspects of the disease by assessing patients' quality of life (QOL) and self-esteem. These measures will aid in better management of acne patients. This study examined the relationship between acne and QOL and self-esteem. The results showed that acne severity may have a considerable adverse impact on QOL and self-esteem. Dermatologists need to emphasize the psychosocial sequelae of acne through awareness programs and encourage medical treatment along with basic psychosomatic remedies in the management of acne. PMID:27622255

  20. Impact of acne vulgaris on quality of life and self-esteem.

    Science.gov (United States)

    Hosthota, Abhineetha; Bondade, Swapna; Basavaraja, Vinay

    2016-08-01

    The psychological impact of acne is determined by various factors including age, sex, personality, grade of disease, scarring, and environmental and ethnic background. Apart from managing the clinical manifestations of acne, clinicians also have to deal with the psychological aspects of the disease by assessing patients' quality of life (QOL) and self-esteem. These measures will aid in better management of acne patients. This study examined the relationship between acne and QOL and self-esteem. The results showed that acne severity may have a considerable adverse impact on QOL and self-esteem. Dermatologists need to emphasize the psychosocial sequelae of acne through awareness programs and encourage medical treatment along with basic psychosomatic remedies in the management of acne.

  1. Clinical efficacy of Kumkumadi Ghrita prepared by Kesar and Nagakesar on Mukhadushika (Acne vulgaris

    Directory of Open Access Journals (Sweden)

    PK Prajapati

    2014-11-01

    Full Text Available Introduction: In spite of large number of treatment options for Mukhdushika (Acne vulgaris, efforts are still carried out by medical society to bring out more effective treatment. Kumkumadi Ghrita (KG is one of the highly valued formulations among Ayurvedic physicians, commonly recommended in Mukhdushika. Kesar (stigma of Crocus sativus Linn is a prime ingredient in the formulation. Due to high cost and increased adulteration trends in Kesar, another botanical ‘Nagakesar’ (stigma of Mesua ferrea Linn. is suggested by Ayurvedic experts as an substitute, which have relatively low cost and possess similar therapeutic attributes like Kesar. However, no published work has been available till date on comparative clinical efficacy of KG prepared by Kesar and Nagakesar. Aims and Objectives: To evaluate the comparative clinical efficacy of Kesaryukta (with Kesar Kumkumadi Ghrita (KKG and Nagakesar yukta (with Nagakesar Kumkumadi Ghrita (NKG. Materials and Methods: Sixty known patients of Mukhdushika of both genders were selected. Both KKG and NKG were used as external application by Abhyanga (massage for 15 minutes and keep it for 10 minutes and then wash face by Besan (Gram powder once in a day, for 4 weeks duration. Suitable diet and lifestyles modifications were advised along with the therapy. The obtained data was analyzed statistically by applying paired ‘t’ test. Results and conclusion: Both groups of KG were found effective in treatment of Mukhdushika. Though, on signs and symptoms, KKG showed comparatively slightly better effect; on overall comparing the clinical efficacy of both groups, statistically no major difference was found. Since NKG is highly cost effective than KKG, present study warrants the use of Nagakesar in place of Kesar for preparation of KG.

  2. Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris.

    Science.gov (United States)

    Layton, Alison M

    2016-04-01

    Acne represents the most common inflammatory dermatosis seen worldwide and is the leading reason for seeing a dermatologist. This article provides some tips for managing acne in a safe and effective manner to minimize the physical and psychological scars that can result from acne. Tips include how to optimize available treatment regimens according to the evidence base and target therapy to pathophysiologic factors, while also tailoring treatments to patient expectation and needs. Attention is given to minimizing the emergence of antimicrobial resistance in acne patients and beyond.

  3. Effect of sequential application of topical adapalene and clindamycin phosphate in the treatment of Japanese patients with acne vulgaris.

    Science.gov (United States)

    Kubota, Yasuo; Munehiro, Asuka; Shirahige, Yoshie; Nakai, Kozo; Katsuura, Junko; Moriue, Tetsuya; Murakami, Yumi; Matsunaka, Hiroshi; Yoneda, Kozo

    2012-02-01

    The efficacy of combined therapy with a retinoid and antibiotic for Japanese patients with acne vulgaris remains to be established. Further, maintenance strategies limiting the use of topical retinoids must be identified. The objectives of this study are to determine the efficacy of sequential application of topical adapalene and clindamycin phosphate and to assess the impact of this regimen on patients' quality of life. Sixty-six patients were recruited. The regimen comprised two phases. For the 4-week initial treatment, 1% clindamycin phosphate gel was applied twice daily and 0.1% adapalene gel, once. In the 4-week maintenance phase, patients were randomly assigned to the OD group (adapalene applied once daily) or the TW group (adapalene applied once daily on 2 days per week). The acne severity score, lesion counts, microcomedone count, and sebum amount were measured. Quality of life (QOL) was assessed using Skindex-16. All parameters improved significantly by week 4 of initial treatment. No statistically significant differences were found in the improvement of clinical findings between the groups. All QOL scores improved significantly and did not significantly differ between the groups. Our regimen may enable clinical control of acne in Japanese patients and improve their QOL. For limiting retinoid use, weekly application of adapalene during maintenance is suitable. PMID:21254867

  4. Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial

    DEFF Research Database (Denmark)

    Haedersdal, M.; Togsverd, K.; Wiegell, S.R.;

    2008-01-01

    Background: Long-pulsed dye laser (LPDL)-assisted photodynamic therapy has been suggested to be superior to laser alone for acne vulgaris but no evidence is available. Objective: To evaluate the efficacy and safety of LPDL alone versus LPDL in photodynamic therapy with methylaminolevulinic acid...

  5. A comparison study of the clinical efficacy and safety of topical adapalene gel (0.1% and tretinoin cream (0.025% in the treatment of acne vulgaris

    Directory of Open Access Journals (Sweden)

    Usha Naraindas Khemani

    2016-06-01

    Conclusions: Adapalene gel 0.1% offers comparable efficacy to tretinoin cream 0.025 % cream , but is less irritating. Adapalene gel 0.1% is a safe and effective topical agent in the treatment of mild to moderate acne vulgaris in Indian patients. [Int J Basic Clin Pharmacol 2016; 5(3.000: 628-634

  6. Intense Pulsed light Versus 1,064 Long-Pulsed Neodymium: Yttrium–Aluminum– Garnet Laser in the Treatment of Facial Acne Vulgaris

    Science.gov (United States)

    Mohamed, Essam Elden; Tawfik, Khaled

    2016-01-01

    Introduction Laser and light-based procedures provide a good and safe modality for treatment of active acne lesions when used properly. Aim To compare the clinical efficacy of intense pulsed light (IPL) versus 1,064 long-pulsed Neodymium:Yttrium–Aluminum– Garnet (Nd: YAG) in treatment of facial acne vulgaris. Materials and Methods Seventy four patients recruited between June 2013 and August 2014 was enrolled in this controlled, single-blind, split-face clinical trial. All participants received 3 sessions of IPL on the right side of the face and 1,064-nm Nd:YAG on the left side of the face at 4-weeks intervals. Final assessment was made by comparison of the changes in the count of inflammatory acne lesions (inflammatory papules, pustules, nodules and cyst) and non-inflammatory acne lesions (Comedones) and the acne severity score between both therapies, based on standardized photography. Results At the final visit, the inflammatory acne lesions were reduced on the IPL and 1,064-nm Nd:YAG treated sides by 67.1% and 70.2% respectively (p0.05 for each). For both therapies, there was significant difference in the improvement on inflammatory acne lesions in comparison to non-inflammatory lesions (p0.05 for each). Conclusion Both IPL and 1,064-nm Nd:YAG laser are effective in treatment of inflammatory facial acne vulgaris. There is no significant difference between the effects of both therapies on facial acne lesions. PMID:27630934

  7. Short-term combination therapy and long-term relapse prevention in the treatment of severe acne vulgaris.

    Science.gov (United States)

    Tan, Jerry; Stein Gold, Linda; Schlessinger, Joel; Brodell, Robert; Jones, Terry; Cruz, Alma; Kerrouche, Nabil; Jarratt, Michael

    2012-02-01

    Few long-term treatment regimens for severe acne vulgaris have been investigated in clinical trials. Data were combined from two consecutive, randomized, double-blind, controlled studies to evaluate the efficacy, safety and subject satisfaction of four nine-month regimens in severe acne vulgaris treatment. Subjects were first randomized to receive doxycycline (DCN) and adapalene 0.1% - benzoyl peroxide 2.5% (A/BPO) or vehicle once daily for 12 weeks. Subjects who had at least 50% global improvement were subsequently randomized to receive A/BPO or its vehicle once daily for 24 weeks. Over nine months, there were four regimens: A/BPO and DCN followed by A/BPO, vehicle and DCN followed by A/BPO, A/BPO and DCN followed by vehicle, and vehicle and DCN followed by vehicle. Among the four regimens, A/BPO and DCN followed by A/BPO led to the highest percentage of subjects rated "clear" or "almost clear" (50.0% vs. 40.4%, 26.2% and 25.0%, respectively), biggest reduction in total lesion counts (76% vs. 70%, 51% and 47%, respectively) and greatest subject satisfaction (85.0% vs. 75.5%, 63.3% and 52.4%, respectively) at week 36. It provided a faster onset of action compared to groups started with vehicle and DCN (PBPO and DCN followed by vehicle experienced deterioration once the active treatment was discontinued. All regimens were safe and well-tolerated. In conclusion, efficacious initial therapy and long-term treatment are both important. An initial combination therapy with adapalene-BPO and DCN followed by longer-term adapalene-BPO treatment is an efficacious and satisfactory new regimen for severe acne subjects.

  8. Acne vulgaris: prevalence and clinical forms in adolescents from São Paulo, Brazil *

    OpenAIRE

    Bagatin, Ediléia; Timpano, Denise Lourenço; Guadanhim, Lilia Ramos dos Santos; Nogueira, Vanessa Mussupapo Andraus; Terzian, Luiz Roberto; Steiner, Denise; Florez, Mercedes

    2014-01-01

    BACKGROUND Acne is a common disease in adolescents, but there are no epidemiological data for acne in Brazil. OBJECTIVES To estimate the prevalence and degree of acne in adolescents from Sao Paulo and study socio-demographic factors, family history and lifestyle, associated with the disease. METHODS Cross-sectional study with 452 adolescents aged between 10 and 17 (mean=13.3 years), students from elementary and high school, examined by 3 independent evaluators. RESULTS 62.4% were female, 85.8...

  9. Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

    Directory of Open Access Journals (Sweden)

    Bowe Whitney P

    2011-01-01

    Full Text Available Abstract Over 70 years have passed since dermatologists John H. Stokes and Donald M. Pillsbury first proposed a gastrointestinal mechanism for the overlap between depression, anxiety and skin conditions such as acne. Stokes and Pillsbury hypothesized that emotional states might alter the normal intestinal microflora, increase intestinal permeability and contribute to systemic inflammation. Among the remedies advocated by Stokes and Pillsbury were Lactobacillus acidophilus cultures. Many aspects of this gut-brain-skin unifying theory have recently been validated. The ability of the gut microbiota and oral probiotics to influence systemic inflammation, oxidative stress, glycemic control, tissue lipid content and even mood itself, may have important implications in acne. The intestinal microflora may also provide a twist to the developing diet and acne research. Here we provide a historical perspective to the contemporary investigations and clinical implications of the gut-brain-skin connection in acne.

  10. Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

    Science.gov (United States)

    Bowe, Whitney P; Logan, Alan C

    2011-01-01

    Over 70 years have passed since dermatologists John H. Stokes and Donald M. Pillsbury first proposed a gastrointestinal mechanism for the overlap between depression, anxiety and skin conditions such as acne. Stokes and Pillsbury hypothesized that emotional states might alter the normal intestinal microflora, increase intestinal permeability and contribute to systemic inflammation. Among the remedies advocated by Stokes and Pillsbury were Lactobacillus acidophilus cultures. Many aspects of this gut-brain-skin unifying theory have recently been validated. The ability of the gut microbiota and oral probiotics to influence systemic inflammation, oxidative stress, glycemic control, tissue lipid content and even mood itself, may have important implications in acne. The intestinal microflora may also provide a twist to the developing diet and acne research. Here we provide a historical perspective to the contemporary investigations and clinical implications of the gut-brain-skin connection in acne. PMID:21281494

  11. Clinical and sebumetric evaluation of topical emulsions in the treatment of acne vulgaris

    OpenAIRE

    Khan, Barkat Ali; Akhtar, Naveed

    2014-01-01

    Introduction Numerous plant products described in the scientific literature show distinct activities on the skin, such as moisturizing, antioxidant, sunscreen, anti-acne and depigmentation. Aim The main objective of this study was to compare the effectiveness of emulsion formulations containing plant extracts (Hippophae rhamnoides and Cassia fistula) and placebo (without plant extracts) on acne patients. Material and methods A single-blind, randomized, placebo-controlled, split-face study was...

  12. A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial

    Directory of Open Access Journals (Sweden)

    Poláková K

    2015-04-01

    Full Text Available Katarína Poláková,1 Aurélie Fauger,2 Michèle Sayag,2 Eric Jourdan2 1Saint Elisabeth´s Oncological Institute, Bratislava, Slovakia; 2Laboratoire Bioderma, Lyon, France Background: Acne vulgaris is an inflammatory disorder of the pilosebaceous unit. Aim: To confirm that BGM (bakuchiol, Ginkgo biloba extract, and mannitol complex increases the established clinical efficacy of adapalene 0.1% gel in patients with acne. Methods: A clinical trial was conducted in acne patients. A total of 111 subjects received adapalene 0.1% gel and BGM complex or vehicle cream for 2 months. Assessments comprised Investigator Global Assessment (IGA, global efficacy, seborrhea intensity, inflammatory and non-inflammatory lesions, and subject perception, as well as overall safety and local tolerance and quality of life. Results: At the end of the trial, inflammatory and non-inflammatory lesions, IGA, global efficacy, and seborrhea intensity had significantly improved in both treatment groups. Differences were statistically significant (P<0.05 in favor of BGM complex for inflammatory lesions as well as IGA and seborrhea intensity. Global efficacy assessments and subject perception confirmed the superiority of BGM complex-including treatment over the comparative combination. Quality of life had improved more with the active combination than with the vehicle combination. In the active group, four subjects had to interrupt temporarily BGM complex and 12 adapalene compared to seven subjects interrupting the vehicle and eleven adapalene in the vehicle group. One subject withdrew from the trial due to an allergy to adapalene. The majority of all events were mild. Conclusion: BGM complex improves the treatment outcome of adapalene 0.1% gel in patients with acne vulgaris. Overall, safety and local tolerance of BGM complex were good. Keywords: adapalene, acne vulgaris, bakuchiol, BGM complex, P. acnes, sebum

  13. Comparison of the efficacy and safety of topical clindamycin and 5% benzoyl peroxide with nadifloxacin cream and 5% benzoyl peroxide gel in the treatment of acne vulgaris and assessment of the effects of these treatments on quality of life

    OpenAIRE

    Aslıhan Kırkağaç; Zeynep Nurhan Saraçoğlu; Ayşe Esra Koku Aksu

    2015-01-01

    Background and Design: Acne vulgaris is a multifactorial chronic inflammatory disase of the pilosebaceous unit. Topical antibiotics and anti-inflammatory treatment are used for mild and moderate acne. Clindamycin is frequently used for acne treatment, altough nadifloxacin is a relatively new agent. There are few studies evaluating nadifloxacin efficacy. It's impact on quality of life has not been determined previously. In this study, it is aimed to compare the effect of these two agents, and ...

  14. Effects of skin care and makeup under instructions from dermatologists on the quality of life of female patients with acne vulgaris.

    Science.gov (United States)

    Matsuoka, Yoshie; Yoneda, Kozo; Sadahira, Chieko; Katsuura, Junko; Moriue, Tetsuya; Kubota, Yasuo

    2006-11-01

    Acne vulgaris significantly affects patients' quality of life (QOL) and their lives in various ways, including social behavior and body dissatisfaction. This may be heightened by acne's typical involvement of the face. We investigated whether the use of skin care and makeup could influence the QOL of affected patients without deteriorating conventional acne treatments. Fifty female patients with acne were recruited for our study. Twenty-five patients were instructed how to use skin care and cosmetics, while 25 patients received no specific instructions from dermatologists. Both groups received conventional topical and/or oral medication for acne during the study period for 4 weeks. Both groups did not show any significant difference in clinical improvement of acne severity. Two validated QOL questionnaires, World Health Organization (WHO)QOL26 and the Dermatology Life Quality Index (DLQI) were administered to all patients at first visit and 4 weeks later. The mean scores of psychological and overall domains in WHOQOL26 for patients with instructions were improved significantly, while only the overall score was significantly improved for patients without instructions. The total mean scores and all domains except work/school in DLQI for patients with instructions were improved significantly, while the total scores and all domains except discomfort for treatment in DLQI were significantly improved for patients without instructions. Thus, instructions on the use of skin care and cosmetics for female acne patients did not deteriorate acne treatment and influenced patients' QOL effectively. We therefore suggest that instructions for using skin care and cosmetics complement conventional medical treatments for acne.

  15. Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females

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    Ola Ahmed Bakry

    2014-01-01

    Full Text Available Context: Acne vulgaris (AV is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process. Aim: The aim of this work was to determine hormonal levels and lipid profile in non-obese, non-hirsute females with AV. Subjects and Methods: A total of 60 non-obese, non-hirsute female cases with different grades of AV and 60 age- and gender-matched healthy volunteers were included. Measurement of serum total and free testosterone, sex hormone binding globulin (SHBG, estradiol and progesterone and blood lipids was done during the luteal phase of the menstrual cycle. Results: Total testosterone, free testosterone (FT and progesterone levels were significantly higher (P < 0.001 for all while estradiol levels (P < 0.001 and SHBG (P < 0.01 were significantly lower in cases than controls. Total cholesterol and low density lipoprotein cholesterol (LDL-C levels were significantly higher (P < 0.001 for both while high density lipoprotein cholesterol (HDL-C and apolipoprotein A-1 (ApoA-1 levels were significantly lower (P < 0.001 for both in cases than controls. Higher values of FT (P = 0.03 and SHBG (P = 0.02 and lower values of estradiol (P = 0.04 levels were significantly in favor of severe acne. Higher values of cholesterol (P < 0.001 and LDL-C (P = 0.03 and lower values of HDL-C (P = 0.01 and ApoA-1 (P = 0.02 levels were significantly associated with severe acne. Conclusion: Changes in hormone levels and lipid profile in non-obese and non-hirsute females with AV should be considered in disease pathogenesis and in treatment prescription of these patients.

  16. Oral isotretinoin in different dose regimens for acne vulgaris: A randomized comparative trial

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    Uma Shankar Agarwal

    2011-01-01

    Full Text Available Background: Oral isotretinoin is recommended for severe nodulocystic acne in the doses of 1-2 mg/kg/day which is usually associated with higher incidence of adverse effects. To reduce the incidence of side-effects and to make it more cost-effective, the lower dose regimen of isotretinoin has been used. Aim: To compare the efficacy and tolerability of oral isotretinoin in daily, alternate, pulse and low-dose regimens in acne of all types and also to assess whether it can be used for mild and moderate acne also. Methods: One hundred and twenty patients with acne were randomized into four different treatment regimens each consisting of 30 patients. Group A was prescribed isotretinoin 1 mg/kg/day, Group B 1 mg/kg alternate day, Group C 1 mg/kg/day for one week/four weeks and Group D 20 mg every alternate day for 16 weeks. Patients were further followed for eight weeks to see any relapse. Side-effects were also recorded. Results: Though the daily high dose treatment Group A performed better initially at eight weeks, at the end of therapy at 16 weeks results were comparable in Group A , B and D. Patients with severe acne did better in Group A than in Group B, C and D. Patients with mild acne had almost similar results in all the groups while patients with moderate acne did better in Group A, B and D. Frequency and severity of treatment-related side-effects were significantly higher in treatment Group A as compared to Group B, C and D. Conclusion: We conclude that for severe acne either conventional high doses of isotretinoin may be used or we can give conventional high dose for initial eight weeks and later maintain on low doses. Use of isotretinoin should be considered in mild to moderate acne also, in low doses; 20 mg, alternate day seems to be an effective and safe treatment option in such cases.

  17. Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    S Choudhury

    2011-01-01

    Full Text Available Background : Topical therapy with comedolytics and antibiotics are often advocated for mild and moderate severity acne vulgaris. Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. This randomized controlled assessor blind trial compared the clinical effectiveness and safety of eight weeks therapy of nadifloxacin 1% versus clindamycin 1% as add-on therapy to benzoyl peroxide (2.5% in mild to moderate grade acne. Materials and Methods : The efficacy parameters were changes in the total, inflammatory and non-inflammatory lesion counts, Investigator Global Assessment (IGA, and Cardiff Acne Disability Index (CADI scales from baseline to study end (eight weeks. All treatment emergent dermatological adverse events were evaluated for safety assessment. Results : Out of 84 randomized subjects (43-nadifloxacin arm and (41-clindamycin 42 in nadifloxacin group, 37 in clindamycin group completed the study. Reduction from baseline of total, inflammatory and non-inflammatory lesion counts were highly significant in both the groups (P<0.0001, but between group differences were not significant. Significant improvement in CADI and IGA scales were noted in both groups. Between-group comparison showed no significant differences. The safety and tolerability profile of both regimens were good and statistically comparable. Conclusions: Topical nadifloxacin, a new fluoroquinolone is effective, tolerable, and safe for mild o moderate facial acne. Its clinical effectiveness is comparable to clindamycin when used as add-on therapy to benzoyl peroxide.

  18. Assessment of nasal carriage of staphylococcus aureus in patients with acne vulgaris

    Directory of Open Access Journals (Sweden)

    Betül Demir

    2015-09-01

    Full Text Available Background and Design: Systemic antibiotics, such as tetracycline and doxycycline are used in the treatment of inflammatory forms of moderate acne, or acne that is resistant to topical treatment. Oral isotretinoin treatment is the most effective treatment option in severe papulopustular and nodular forms of acne. Dose-related nasal carrier state of Staphylococcus aureus (S. aureus, has been reported in 90% of patients using isotretinoin. Long-term oral and/or topical antibiotic use in the treatment of acne causes changes in antibiotic susceptibility and emergence of methicillin-resistant S. aureus (MRSA pathogens. The present retrospective study examined the colonization rates of S. aureus in patients who had an increase in acneiform lesions while taking medications for the treatment of acne and whose nasal swap samples were obtained and also investigated their relationship with treatment options. Materials and Methods: A total of 86 patients with moderate acne who attended our dermatology outpatient clinic with the complaints of acne and in whom nasal swap samples were obtained due to increased pustules during acne therapy. The patients were divided into three groups according to the treatment methods as patients receiving topical treatment, patients treated with oral doxycycline, and patients treated with oral isotretinoin. The results of the cultures were evaluated in three groups: no growth, methicillin-sensitive S. aureus (MSSA, and MRSAisolated. Results: 39.5% culture positivity (S. aureus were determined in 34 patients. Thirty two (94.1% culture positivity were MSSA, and 2 (5.9% culture positivity were MRSA. Twenty nine (58% culture positivity were found in the patients using the oral isotretinoin. There was statistically significant culture positivity in the patients using oral isotretinoin compared to patients receiving other treatments (p<0.001. Conclusion: We observed that S. aureus colonization increased in patients using systemic

  19. 针灸治疗寻常性痤疮临床观察%Clinical Therapeutic Effect of Acupuncture Treatment for Acne Vulgaris

    Institute of Scientific and Technical Information of China (English)

    孙亦农; 陈丽姝

    2013-01-01

    目的:采用近部选穴与远部选穴配合,针刺与放血结合的方法,观察针灸治疗寻常性痤疮的临床疗效.方法:采用痤疮综合分级系统量表(GAGS),对比观察针灸治疗前后及不同疗程对寻常性痤疮各类皮损的疗效影响.结果:寻常性痤疮患者通过8周针刺治疗后,绝大部分患者在痤疮各类皮损方面都有所好转,并且有显著的统计学意义(P<0.001).结论:近部选穴与远部选穴配合,针刺与放血结合的方法对寻常性痤疮的疗效是十分确切的,而且随治疗周期的增加而增加.%Objective:This study was to observe the clinical effect of acupuncture treatment combined with blood-letting at local points plus distant points on acne vulgaris.Methods:The Global Acne Gading System (GAGS) scale was used to contrast and the effect on various types of skin lesions caused by acne vulgaris was observed before and after treatments and the changes of these skin lesions in different treatment cycles were also observed.Results:After eight weeks treatment,the vast majority of patients in all types of acne lesions had been improved,and there was a significant statistical difference (P < 0.001).Conclusion:Filiform needle acupuncture combined with blood-letting can be the valid treatment for acne vulgaris,and the efficacy is associated with treatment cycles.

  20. Interaction and efficacy of Keigai-rengyo-to extract and acupuncture in male patients with acne vulgaris: A study protocol for a randomized controlled pilot trial

    OpenAIRE

    Kim Yoon-Bum; Kim Kyu

    2011-01-01

    Abstract Background In consideration of patients seeking to use traditional Chinese medicine, an evidence-based potentiality for safe and effective use of herbal medicine and acupuncture in treatment of acne vulgaris has been suggested. However, despite common use of a combination of herbal medicine and acupuncture in clinical practice, the current level of evidence is insufficient to draw a conclusion for an interaction and efficacy of herbal medicine and acupuncture. Therefore, considering ...

  1. Integrated cooling-vacuum-assisted 1540-nm erbium:glass laser is effective in treating mild-to-moderate acne vulgaris.

    Science.gov (United States)

    Politi, Y; Levi, A; Enk, C D; Lapidoth, M

    2015-12-01

    Acne treatment by a mid-infrared laser may be unsatisfactory due to deeply situated acne-affected sebaceous glands which serve as its target. Skin manipulation by vacuum and contact cooling may improve laser-skin interaction, reduce pain sensation, and increase overall safety and efficacy. To evaluate the safety and efficacy of acne treatment using an integrated cooling-vacuum-assisted 1540-nm erbium:glass laser, a prospective interventional study was conducted. It included 12 patients (seven men and five women) suffering from mild-to-moderate acne vulgaris. The device utilizes a mid-infrared 1540-nm laser (Alma Lasers Ltd. Caesarea, Israel), which is integrated with combined cooling-vacuum-assisted technology. An acne lesion is initially manipulated upon contact by a vacuum-cooling-assisted tip, followed by three to four stacked laser pulses (500-600 mJ, 4 mm spot size, and frequency of 2 Hz). Patients underwent four to six treatment sessions with a 2-week interval and were followed-up 1 and 3 months after the last treatment. Clinical photographs were taken by high-resolution digital camera before and after treatment. Clinical evaluation was performed by two independent dermatologists, and results were graded on a scale of 0 (exacerbation) to 4 (76-100 % improvement). Patients' and physicians' satisfaction was also recorded. Pain perception and adverse effects were evaluated as well. All patients demonstrated a moderate to significant improvement (average score of 3.6 and 2.0 within 1 and 3 months, respectively, following last treatment session). No side effects, besides a transient erythema, were observed. Cooling-vacuum-assisted 1540-nm laser is safe and effective for the treatment of acne vulgaris.

  2. Drospirenone/ethinylestradiol 3mg/20microg (24/4 day regimen): a review of its use in contraception, premenstrual dysphoric disorder and moderate acne vulgaris.

    Science.gov (United States)

    Fenton, Caroline; Wellington, Keri; Moen, Marit D; Robinson, Dean M

    2007-01-01

    Drospirenone 3mg with ethinylestradiol 20microg (Yaz) is a low-dose combined oral contraceptive (COC) administered in a regimen of 24 days of active tablets followed by a short hormone-free interval (4 days; 24/4 regimen). Drospirenone, unlike other synthetic progestogens used in COCs, is a 17alpha-spirolactone derivative and a 17alpha-spironolactone analogue with antimineralocorticoid and antiandrogenic properties. Drospirenone/ethinylestradiol 3mg/20microg (24/4) is approved in the US for the prevention of pregnancy in women, for the treatment of the symptoms of premenstrual dysphoric disorder (PMDD) and for the treatment of moderate acne vulgaris in women who wish to use an oral contraceptive for contraception.Drospirenone/ethinylestradiol 3mg/20microg (24/4) provided 99% contraceptive protection over 1 year of treatment in two large studies. The same treatment regimen over three treatment cycles also significantly improved the emotional and physical symptoms associated with PMDD, and improved moderate acne vulgaris over six treatment cycles in double-blind trials. It was generally well tolerated, with adverse events generally typical of those experienced with other COCs and which were most likely to occur in the first few cycles. Clinical trials indicate that drospirenone/ethinylestradiol 3mg/20microg (24/4) is a good long-term contraceptive option, and additionally offers relief of symptoms that characterise PMDD and has a favourable effect on moderate acne vulgaris. PMID:17683173

  3. Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

    OpenAIRE

    Bowe Whitney P; Logan Alan C

    2011-01-01

    Abstract Over 70 years have passed since dermatologists John H. Stokes and Donald M. Pillsbury first proposed a gastrointestinal mechanism for the overlap between depression, anxiety and skin conditions such as acne. Stokes and Pillsbury hypothesized that emotional states might alter the normal intestinal microflora, increase intestinal permeability and contribute to systemic inflammation. Among the remedies advocated by Stokes and Pillsbury were Lactobacillus acidophilus cultures. Many aspec...

  4. Importance of androgens in acne

    OpenAIRE

    Luz Stella Montoya de Bayona

    2002-01-01

    Several factor play animportant role in acne. Acne vulgaris affect pilosebaceousunit while in inversa acne affect terminal folicule. There is aninflammatory process with negative outcome when diagnosisand accurate treatment is delayed. Abnormal androgenproduction help acne apparition by stimulating seborrheicsecretion and queratinocitic growth in follicular channel. Thischange appear clinically by different forms, by example,hirsutism, seborrhea, acne, alopecia, and obesity. SAHAand Hair-an a...

  5. 针灸治疗寻常痤疮的疗效综合判定%Acupuncture for Acne Vulgaris Evaluation of the Comprehensive Effectiveness

    Institute of Scientific and Technical Information of China (English)

    陈然; 黎波; 杜元灏; 王栩

    2012-01-01

    目的:综合判定针灸治疗寻常痤疮(ACNE)的疗效.方法:运用循症医学的方法获得临床证据评价针灸治疗寻常痤疮的有效性和安全性;通过模糊综合评判技术对全国针灸专家问卷调查结果进行处理,评价针灸治疗寻常痤疮的效能等级.结果:2项A级证据支持针灸治疗寻常痤疮的有效性.6项研究结果显示针灸治疗寻常痤疮的复发率低于阳性药物.专家问卷调查结果显示针灸治疗寻常痤疮的疗效趋势为:Ⅰ度为临床治愈;Ⅱ度、Ⅲ度为整体好转;Ⅳ度为部分缓解.结论:现阶段研究表明针灸治疗寻常痤疮有效,且安全性高、复发率低:Ⅰ度寻常痤疮疗效等级为效能针灸Ⅰ级病谱,Ⅱ度、Ⅲ度寻常痤疮疗效等级为效能针灸Ⅱ级病谱,Ⅳ度寻常痤疮疗效等级为Ⅲ级病谱.%Objective : To comprehensively evaluate the effectiveness of acupuncture for Acne vulgaris ( ACNE ) . Methods; Collect the high quality evidence relative to clinical acupuncture evidence for acne based on EBM to evaluate effectiveness and safety The acade-mic investigation result of acupuncture experts opinions from these clinical experience were classified by fuzzy comprehensive estimation technique to acquire a grade-disease-spectrum on acne. Results; Obtain two Level A evidences showed effectiveness of acupuncture. Six studies showed treatment of acne by acupuncture with positive medicine as control has a lower recurrence rate. The investigation illustrated the effect of acupuncture for Ⅰ-ACNE is cured. The investigation illustrated the effect of acupuncture for Ⅱ- ACNE and Ⅲ- ACNE are the tendency of overall improvement. The investigation illustrated the effect of acupuncture for Ⅳ- ACNE is partially released. Conclusion: Acupuncture is an effective treatment in acne supported by limited evidences with a lower recurrence rate and fewer adverse reaction; the Ⅰ - ACNE is included in Grade - DiseasevSpectrum level

  6. Multicenter study to evaluate efficacy and irritation potential of benzoyl peroxide 4% cream in hydrophase base (Brevoxyl in acne vulgaris

    Directory of Open Access Journals (Sweden)

    Sawleshwarkar S

    2003-01-01

    Full Text Available In this multicenter, open, non-comparative study, the efficacy and irritation potential of 4% benzoyl peroxide cream in hydrophase base (Brevoxyl was evaluated for the treatment of acne vulgaris. All evaluable patients (n=567 received treatment with 4% benzoyl peroxide cream in hydrophase base for six weeks. The investigators evaluated the patients at baseline and at 1,2,4 & 6 weeks. Patients also rated their improvement and adverse effects. Doctor′s assessment showed that at the end of 6′h week 85.6% had good to very good effect of the treatment. The profile of side effects observed by doctors revealed that 53.8% of total patients did not have any irritation whereas only 11.6% had moderate to severe irritation. 53.8% of patients did not report any irritation: 41.4% had some irritation whereas only 4.8% patients reported troublesome irritation. A satisfactory response was reported as ear;y as two weeks and most of the patients had a very satisfactory response after six weeks and were willing to continue the treatment. This supports the theory that the hydrophase formulation in ′Brevoxyl helped to enhance efficacy and decrease the irritation associated with use of benzoyl peroxide.

  7. The impact of acne vulgaris on quality of life and psychic health in young adolescents in Greece: results of a population survey O impacto da acne vulgar na qualidade de vida e saúde psíquica em jovens adolescentes na Grécia: resultados de uma pesquisa populacional

    Directory of Open Access Journals (Sweden)

    Eleni Tasoula

    2012-12-01

    Full Text Available BACKGROUND: Acne vulgaris can severely affect social and psychological functioning. OBJECTIVE: The aim of this study was to investigate the impact of acne vulgaris and its severity on Quality of Life of young adolescents in Greece. METHODS: We conducted a questionnaire based survey among 1560 adolescent between the ages of 11 and 19 years old and 1531 of these were completed. Adolescents with acne filled all the questions including the Children Dermatology Life Quality Index. Adolescents without acne filled the questions about age, family history of acne, stress and smoking. Data were analyzed with Pearson Chi Square test. RESULTS: Acne prevalence was 51.2% affecting both sexes equally. Self reported mild acne was present in 71.2% and moderate-severe acne in 28.8% of the study population. The mean age of the study population was 15.77y. The median score of Children Dermatology Life Quality Index was 4.02. The impact of acne on quality of life is associated with the severity of the acne (pFUNDAMENTOS: Acne vulgar pode afetar seriamente o funcionamento social e psicológico. OBJETIVO: O objetivo deste estudo foi investigar o impacto da acne vulgar e sua gravidade na Qualidade de Vida de jovens adolescentes na Grécia. MÉTODOS: Nós conduzimos uma pesquisa baseada em questionário entre 1560 adolescentes com idades entre 11 e 19 anos e 1531 destes foram completados. Adolescentes com acne completaram todas as questões incluindo o Children Dermatology Life Quality Index (CDLQI. Adolescentes sem acne completaram as questões sobre idade, história familiar de acne, estresse e tabagismo. Os dados foram analisados pelo teste de chi-quadrado de Pearson. RESULTADOS: A prevalência de acne foi de 51.2%, afetando igualmente ambos os sexos. O auto relato de acne leve estava presente em 71.2% e de acne moderada a grave em 28.8% da população. A idade média da população em estudo foi de 15.77 anos. O escore médio do Children Dermatology Life Quality

  8. Interaction and efficacy of Keigai-rengyo-to extract and acupuncture in male patients with acne vulgaris: A study protocol for a randomized controlled pilot trial

    Directory of Open Access Journals (Sweden)

    Kim Yoon-Bum

    2011-03-01

    Full Text Available Abstract Background In consideration of patients seeking to use traditional Chinese medicine, an evidence-based potentiality for safe and effective use of herbal medicine and acupuncture in treatment of acne vulgaris has been suggested. However, despite common use of a combination of herbal medicine and acupuncture in clinical practice, the current level of evidence is insufficient to draw a conclusion for an interaction and efficacy of herbal medicine and acupuncture. Therefore, considering these methodological flaws, this study was designed to assess the interaction and efficacy of an available herbal medicine, Keigai-rengyo-to extract (KRTE, and acupuncture for treatment of acne using the 2 × 2 factorial design and the feasibility of a large clinical trial. Methods/Design A randomized, assessor single blinded, 2 × 2 factorial pilot trial will be conducted. Forty four participants with acne vulgaris will be randomized into one of four groups: waiting list group (WL, KRTE only group (KO, acupuncture only group (AO, and KRTE and acupuncture combined treatment group (KA. After randomization, a total of 8 sessions of acupuncture treatment will be performed twice a week in the AO- and KA groups, respectively. Patients in the KO- and KA groups will be prescribed KRTE 3 times a day at a dose of 7.4 g after meals for 4 weeks. The following outcome measurements will be used in examination of subjects: the mean percentage change and the count change of inflammatory and non-inflammatory acne lesions, the Skindex 29, visual analogue scale (VAS and investigator global assessment (IGA from baseline to the end of the trial. Trial Registration The trial is registered with the Clinical Research Information Service (CRiS, Republic of Korea: KCT0000071.

  9. Topical retinoids for acne.

    Science.gov (United States)

    Yeh, Lindsey; Bonati, Lauren Meshkov; Silverberg, Nanette B

    2016-06-01

    Topical retinoids are currently approved by the US Food and Drug Administration for the treatment of acne vulgaris in nonpregnant, nonlactating patients 12 years of age and older. Their efficacy, safety, and tolerability are well documented for inflammatory and noninflammatory acne with studies repeatedly demonstrating a decrease in the number of lesions, significant improvement in acne severity, improvement in the cosmetic appearance of acne, and the prevention of acne lesions through microcomedone formation. There is some variability between prescription retinoid products regarding efficacy, safety, and tolerability; with erythema, peeling, and dryness being common, potential side effects. Due to their efficacious and safe profile, topical retinoids remain the first-line treatment for acne vulgaris. PMID:27416308

  10. Acne: What's New.

    Science.gov (United States)

    Stein Gold, Linda F

    2016-06-01

    Acne vulgaris is one of the most prevalent skin conditions. Antibiotics, when considered, are most effective in combination with other therapies, and limited evidence suggests that submicrobial doses of antibiotics may improve acne without increasing the risk for antibiotic resistance. A small but significant risk for inflammatory bowel disease has also been identified in children treated with multiple courses of antibiotics. New topical agents are expanding therapeutic options for acne. Semin Cutan Med Surg 35(supp6):S114-S116. PMID:27538054

  11. EFFICACY OF IPL IN TREATMENT OF ACNE VULGARIS : COMPARISON OF SINGLE- AND BURST-PULSE MODE IN IPL

    OpenAIRE

    Kumaresan M; Srinivas C

    2010-01-01

    Background: Intense pulsed light (IPL) has been used for the treatment of facial acne. Modifications of various parameters allow flexibility in treatment, which include energy fluence, pulse duration, and pulse delay. We compared the efficacy of burst-pulse (multiple pulse) mode with single-pulse mode in treatment of acne. Objective: This study was designed to evaluate the efficacy of the IPL in treatment of facial acne and to compare burst-pulse and single-pulse mode in treatment of acne. Ma...

  12. Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial.

    Science.gov (United States)

    Kelidari, Hamid Reza; Saeedi, Majid; Hajheydari, Zohreh; Akbari, Jafar; Morteza-Semnani, Katayoun; Akhtari, Javad; Valizadeh, Hadi; Asare-Addo, Kofi; Nokhodchi, Ali

    2016-10-01

    Spironolactone (SP) known as an anti-androgen drug, has been proven to be effective in treatment of acne. The quest to minimize the unnecessary systemic side effects associated with the oral drug administration of spironolactone, has led to a growing interest of loading SP on lipid nanoparticles to deliver the drug in a topical formulation. The aim of the current investigation was to prepare and compare the performance of SP loaded nanostructured lipid carrier (SP-NLC) and SP alcoholic gels (SP-ALC) on two groups of respective patient populations, group A and group B in the treatment of mild to moderate acne vulgaris. The results showed that SP-NLCs were spherical in shape with an average diameter of ∼240nm. The polydispersity index (PI) and zeta potential of these nanoparticles were 0.286 and -21.4 respectively. The gels showed non-Newtonian independent pseudoplastic and shear thinning behavior. The SP-NLCs was not toxic to fibroblast cell strains at the 24 and 48h periods. Results showed that the mean number of total lesions (37.66±9.27) and non-inflammatory lesions (29.26±7.99) in group A significantly decreased to 20.31±6.58 (pacne vulgaris with skin care benefits. PMID:27248464

  13. Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial.

    Science.gov (United States)

    Kelidari, Hamid Reza; Saeedi, Majid; Hajheydari, Zohreh; Akbari, Jafar; Morteza-Semnani, Katayoun; Akhtari, Javad; Valizadeh, Hadi; Asare-Addo, Kofi; Nokhodchi, Ali

    2016-10-01

    Spironolactone (SP) known as an anti-androgen drug, has been proven to be effective in treatment of acne. The quest to minimize the unnecessary systemic side effects associated with the oral drug administration of spironolactone, has led to a growing interest of loading SP on lipid nanoparticles to deliver the drug in a topical formulation. The aim of the current investigation was to prepare and compare the performance of SP loaded nanostructured lipid carrier (SP-NLC) and SP alcoholic gels (SP-ALC) on two groups of respective patient populations, group A and group B in the treatment of mild to moderate acne vulgaris. The results showed that SP-NLCs were spherical in shape with an average diameter of ∼240nm. The polydispersity index (PI) and zeta potential of these nanoparticles were 0.286 and -21.4 respectively. The gels showed non-Newtonian independent pseudoplastic and shear thinning behavior. The SP-NLCs was not toxic to fibroblast cell strains at the 24 and 48h periods. Results showed that the mean number of total lesions (37.66±9.27) and non-inflammatory lesions (29.26±7.99) in group A significantly decreased to 20.31±6.58 (pacne vulgaris with skin care benefits.

  14. 寻常型痤疮的中医外治体会%Experience of Chinese medicine in the external treatment to acne vulgaris

    Institute of Scientific and Technical Information of China (English)

    刘祖丽

    2014-01-01

    痤疮是一种好发于青春期男女的皮肤疾病。易反复发作,影响容颜美观,特别是中重度(Ⅱ-Ⅳ度)寻常性痤疮给患者容貌及心理健康带来严重影响。中医外治法对其有较好的疗效。通过介绍毫针刺法、放血疗法、穴位注射、梅花针面部叩刺、中药面膜、中药熏蒸等常用的中医外治方法,进一步探讨中重度寻常性痤疮的治疗。%Acne is a skin disease,occurs in adolescents.It’ s easy to repeated attacks,affect the appearance of beautiful ,es-pecially in moderate to severe (Ⅱ-Ⅳ)acne vulgaris has seriously affected the appearance and the mental health of patients,with ex-ternal therapy of traditional Chinese medicine,has a good effect on the diseases.Through the introduction of traditional Chinese medi-cine treatment of acupuncture,bloodletting therapy,acupoint injection,plum blossom needle facial tapping,herbal mask,herbal fumi-gation and other commonly used,in order to improve the treatment of moderate to severe acne vulgaris.

  15. Photodynamic therapy of acne vulgaris%光动力疗法治疗寻常痤疮的研究进展

    Institute of Scientific and Technical Information of China (English)

    黄秋红; 王丹; 周炳荣; 骆丹

    2011-01-01

    寻常痤疮是临床上最常见的皮肤病之一,是一种由多因素综合作用引起的,累及毛囊皮脂腺的慢性炎症性皮肤病,其发病率呈逐年上升的趋势,并且影响患者的生活质量.传统的治疗方法为局部或系统治疗,具有潜在的毒副作用,加之细菌对抗生素耐药性的不断增加.近年来,光动力疗法已广泛应用于痤疮的治疗中,并成为治疗痤疮的有效方法,尤其是针对炎症性痤疮,其疗效优于单独光照治疗.光动力疗法的光源主要有二极管激光、强脉冲光、蓝光、红光.研究结果显示,该疗法安全、有效,不良反应较小.%Acne vulgaris,one of the most common skin diseases,is a multifactorial and chronic inflammatory disorder of pilosebaceous follicles with severe impact on the quality of life of patients.The incidence of acne vulgaris has been increasing yearly.The application of conventional local and systemic treatments for ance vulgaris is limited by their potential toxic and side effects as well as increasing resistance of bacteria to antibiotics.Recently,photodynamic therapy has been widely applied to the treatment of acne,and proved to be an effective treatment choice.In particular,the efficacy of photodynamic therapy appears superior to that of single phototherapy.The light sources of photodynamic therapy mainly include diode lasers,intense pulsed light,blue light and red light.There is considerable evidence that photodynamic therapy is safe and effective for the treatment of ance vulgaris with less side effects.

  16. Baby Acne (Neonatal Acne)

    Science.gov (United States)

    ... and rashes clinical tools newsletter | contact Share | Baby Acne (Neonatal Acne) A parent's guide for infants and babies A A A Acne whiteheads and bumps (papules) typically involve the forehead ...

  17. Diet, Smoking and Family History as Potential Risk Factors in Acne Vulgaris – a Community-Based Study

    Directory of Open Access Journals (Sweden)

    Al Hussein Stela Mariana

    2016-06-01

    Full Text Available Objective. This study aimed to evaluate the effects of practices and attitudes towards lifestyle in adolescence as risk or protective factors, for both the acne occurrence and lesions’ severity.

  18. Monte Carlo study of skin optical clearing to enhance light penetration in the tissue: implications for photodynamic therapy of acne vulgaris

    Science.gov (United States)

    Bashkatov, Alexey N.; Genina, Elina A.; Tuchin, Valery V.; Altshuler, Gregory B.; Yaroslavsky, Ilya V.

    2008-06-01

    Result of Monte Carlo simulations of skin optical clearing is presented. The model calculations were carried out with the aim of studying of spectral response of skin under immersion liquids action and calculation of enhancement of light penetration depth. In summary, we have shown that: 1) application of glucose, propylene glycol and glycerol produced significant decrease of light scattering in different skin layers; 2) maximal clearing effect will be obtained in case of optical clearing of skin dermis, however, absorbed light fraction in skin dermis changed insignificantly, independently on clearing agent and place it administration; 3) in contrast to it, the light absorbed fraction in skin adipose layer increased significantly in case of optical clearing of skin dermis. It is very important because it can be used for development of optical methods of obesity treatment; 4) optical clearing of superficial skin layers can be used for decreasing of power of light radiation used for treatment of acne vulgaris.

  19. The sequence of inflammation, relevant biomarkers, and the pathogenesis of acne vulgaris: what does recent research show and what does it mean to the clinician?

    Science.gov (United States)

    Del Rosso, James Q; Kircik, Leon H

    2013-08-01

    Acne vulgaris (AV) remains one of the most common skin disorders seen in dermatology practices worldwide. Despite an abundance of publications, AV continues to be a formidable therapeutic challenge due to its complex pathogenesis and chronicity. Regarding the sequence of AV lesion formation, the traditional model teaches that the primary lesion is the microcomedone, a subclinical lesion caused by follicular hyperkeratinization. From the microcomedone, visible AV emerges with development of comedonal ("noninflammatory") and inflammatory lesions. Research published over the past decade has provided information about inflammatory mechanisms that warrant us reconsidering the traditional model of AV pathogenesis. More specifically, there is evidence that specific cascades of inflammation occur early during the initial subclinical formation and visible emergence of AV lesions, later during progression, and finally during resolution including scarring. It has also been shown that subclinical inflammation occurs before or concurrently with microcomedone formation. This article reviews an updated model of acne lesion development and its progression based on a literature review that highlights the role of inflammatory mediators, cellular infiltration patterns, and expression of receptors that signal specific immunologic and inflammatory responses. Clinical relevance related to this updated model is also addressed.

  20. Acne compression joint red blue light observation and nursing for the treatment of acne vulgaris%粉刺挤压术联合红蓝光照射治疗寻常性痤疮疗效观察与护理

    Institute of Scientific and Technical Information of China (English)

    陈海燕; 郑跃; 区凤仙; 杨素莲; 万苗坚; 陆春; 赖维

    2015-01-01

    Objective To explore the curative effect of acne compression joint red blue light on acne vulgaris and nursing measures. Methods In 132 cases of acne vulgaris were treated by compression with red and blue light therapy,and cooperate with the nursing care. Results After the treatment,105 of them got recovered(79.55% ),19 remarkably imporved(14.39% ),8 slighly improved(6.06% )and 0 ineffectively treated.The total effective rate was 93.94%. Conclusion Acne compression joint red blue light is effective for the treatment of acne vulgaris.Hight quality nursing can ensure and improve the efficiency of the acne compression joint red blue ligh.%目的:探讨粉刺挤压术联合红蓝光照射治疗寻常性痤疮的疗效及护理要点。方法:对132例寻常性痤疮患者采用粉刺挤压术联合红蓝光照射治疗,并配合做好护理工作。结果:132例患者经4周治疗后,痊愈105例(79.55%),显效19例(14.39%),有效8例(6.06%),无效0例,总有效率为93.94%。结论:粉刺挤压术联合红蓝光照射是治疗寻常性痤疮的有效治疗方法,良好的护理措施能保证和提高联合治疗寻常性痤疮的疗效。

  1. Low-Dose Topical 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Different Severity of Acne Vulgaris.

    Science.gov (United States)

    Tao, Shi-Qin; Li, Fei; Cao, Lei; Xia, Ru-Shan; Fan, Hua; Fan, Ying; Sun, Hui; Jing, Cheng; Yang, Li-Jia

    2015-12-01

    The objective of this article is to investigate the effectiveness and safety of photodynamic therapy (PDT) with 3.6 % topical aminolevulinic acid (ALA) and a short incubation time with red light in moderate to severe acne. One hundred and thirty-six patients with moderate to severe acne were treated with 3.6 % topical ALA-PDT for three sessions with an interval of 2 weeks. Patients were evaluated for efficacy and safety on week 2, 4, 6, 8, and 12 after the initial treatment. Most patients showed apparent clearance of acne lesions at the treated site after three sessions. The effective treatment rates were increased after the multiple therapies. The clinical outcomes are the best at 4 weeks after the final treatment. The total effectiveness rate and cure rate of the low-dose ALA-PDT procedure is 92.65 and 47.06 %, respectively. Thirty-one patients and nineteen patients showed apparent exacerbation of acne lesions before the 2nd and 3rd treatment, respectively, but all of them showed good or excellent improvement after a three-course treatment. A few patients showed mild relapse including papules and comedos at 8 weeks after the final treatment. No significant differences are found in the effects of different acne severity and different genders. Adverse reactions are mild and transient. A 3.6 % topical ALA-PDT with a short time incubation with red light is a simple and an effective treatment option for moderate to severe acne with mild side effects in Chinese people.

  2. Prevalence of acne in primary school children and the relationship of acne with pubertal maturation

    Directory of Open Access Journals (Sweden)

    Hilal Kaya Erdoğan

    2014-12-01

    Full Text Available Background and Design: Although acne vulgaris is generally regarded as a disease of adolescence period, it can occur in infancy, early childhood and prepubertal period. Acne may emerge as the first sign of pubertal maturation. In our study, we aimed to determine the acne prevalence in primary school children, then, evaluate the pubertal signs in those children; examine the correlation of the presence and severity of acne with pubertal signs, and finally, revise the concept of prepubertal acne. Materials and Methods: A thousand students from 2 schools in Istanbul were included in the study. Age, gender, and the presence, localization and severity of acne were recorded. Acne severity was evaluated using the Orfanos-Gollnick Acne Grading System while a validated self evaluation form which had been developed by Morris and Udry was used to evaluate pubertal stage. Data were evaluated statistically. Results: Five hundred and thirty-four male and 466 female primary school children, with an age range of 7 to 11, were included in the study. Acne was determined in 11.5% of the students. 20% of girls and 4% of boys had acne. Comparing acne presence and age, the average age was higher in group with acne than those with no acne. The mean age of children with grade 1 acne was lower than those with grade 2 acne. All the students with acne had mid-facial acne. Comparing acne presence and pubertal symptoms, the rate of the presence of acne was higher in pubertal girls. No acne was observed in prepubertal boys. Evaluating acne severity and pubertal signs, the difference between prepubertal and pubertal girls was not significant. Comparing acne and telarche stages, the group without acne had lower telarche rates. Comparing acne and pubertal stages, children with acne had advanced puberty. Conclusion: Our study denotes that acne prevalence is related to pubertal maturation and age; while it does not support the hypothesis that acne is the first sign of pubertal

  3. Contraceptive use in acne.

    Science.gov (United States)

    Lam, Charlene; Zaenglein, Andrea L

    2014-01-01

    Acne vulgaris is an inflammatory disorder of the pilosebaceous follicle. It is well established that androgen hormones play a major role in sebum production and excretion, and are vital in the pathogenesis of acne. Isotretinoin notwithstanding, hormonal therapies such as combined oral contraceptives (COCs) and spironolactone are the only treatments that can affect sebum production and the androgen component of acne. Contraceptives are also used during isotretinoin therapy for pregnancy prevention. It is important for a dermatologist to be familiar with all the available methods of contraception to provide essential counseling to patients. The aim of this paper is to review the role of hormones in acne pathogenesis, discuss the use of hormonal therapies for acne, and detail various alternative contraceptive methods in relation to isotretinoin treatment and pregnancy prevention. PMID:25017461

  4. Self-reported acne is not associated with prostate cancer

    NARCIS (Netherlands)

    Cremers, R.G.H.M.; Aben, K.K.H.; Vermeulen, S.; Heijer, M. den; Oort, I.M. van; Kerkhof, P.C.M. van de; Schalken, J.A.; Kiemeney, L.A.L.M.

    2014-01-01

    OBJECTIVE: Some studies have suggested an inverse association between acne vulgaris and the acne-related bacterium Propionibacterium acnes and prostate cancer (PCa). Self-reported acne might be an easily obtainable marker to identify men at relatively low risk of PCa and might be incorporated into P

  5. Comparison of the efficacy and safety of topical clindamycin and 5% benzoyl peroxide with nadifloxacin cream and 5% benzoyl peroxide gel in the treatment of acne vulgaris and assessment of the effects of these treatments on quality of life

    Directory of Open Access Journals (Sweden)

    Aslıhan Kırkağaç

    2015-03-01

    Full Text Available Background and Design: Acne vulgaris is a multifactorial chronic inflammatory disase of the pilosebaceous unit. Topical antibiotics and anti-inflammatory treatment are used for mild and moderate acne. Clindamycin is frequently used for acne treatment, altough nadifloxacin is a relatively new agent. There are few studies evaluating nadifloxacin efficacy. It's impact on quality of life has not been determined previously. In this study, it is aimed to compare the effect of these two agents, and to evaluate the effect of these treatments on quality of life. Materials and Methods: Eighty patients with mild-moderate acne vulgaris were divided in two groups of 40 people that had no difference in terms of age, gender and acne severity. The combination of topical clindamycin and 5% benzoyl peroxide gel twice a day was given to group 1 for 12 weeks. The combination of nadifloxacin cream and 5% benzoyl peroxide gel twice a day was given to group 2 for 12 weeks. The number of the inflammatory and non-inflammatory lesions were recorded at baseline and on weeks 2, 4, 8, 12 and side effects were recorded and evaluated. Global improvement was evaluated separately by patients and doctor after the treatment. Before and after the treatment, the quality of life of the patients were evaluated with Skindex-29. Results: Both treatment group regimens were significantly effective on inflammatory and non-inflammatory lesions and were well tolerated by patients in terms of side effects. It was also observed that there was statistically significant recovery after treatment in terms of clinical severity and quality of life. There was not any statistically significant difference between two treatment methods in terms of effectiveness, side effect and quality of life. Conclusion: Nadifloxacin and 5% benzoyl peroxide combination is effective in the treatment and improvement of quality of life in acne patients.

  6. Comparison of Safety and Efficacy of Oral Azithromycin-Topical Adapalene Versus Oral Doxycycline-Topical Adapalene in the Treatment of Acne Vulgaris and Determination of the Effects of These Treatments on Patients’ Quality of Life

    Directory of Open Access Journals (Sweden)

    Serap Kayhan

    2012-09-01

    Full Text Available Background and Design: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Oral antibiotics and topical retinoids are effective in the treatment of acne.Materials and Methods: In this study, 60 patients with moderate acne vulgaris were evaluated; the patients were randomized into two equal groups. The groups were matched with respect to age, gender and clinical severity of acne. The patients in group 1 received oral azithromycin (500 mg daily on 3 consecutive days per week and the patients in group 2 received doxycycline (100 mg daily for 12 weeks. Topical adapalene gel was added to the systemic treatment in both groups. Clinical evaluation was performed at baseline and at the end of first, second and third months. Side effects were recorded. Quality of life in patients was measured with Skindex-29 and Acne Quality of Life Scale before treatment and at the end of third month. Results: At the end of the treatment, the patients in the two treatment groups had clinical improvement of more than 50%. Twenty-one patients in the azithromycin-adapalene group and 23 patients in the doxycycline-adapelene group had more than 80% clinical improvement. There was not any statistically significant difference in the clinical efficacy between the two combinations. Both treatment regimens were safe with minimal side effects. There was statistically significant difference in Skindex-29 and Acne Quality of Life Scale scores at baseline and at the end of the treatment (p0.05. Conclusion: Both treatments were efficient and safe. There was significant improvement in quality of life scale scores in both groups.

  7. Efficacy and safety of a nano-emulsion gel formulation of adapalene 0.1% and clindamycin 1% combination in acne vulgaris: A randomized, open label, active-controlled, multicentric, phase IV clinical trial

    Directory of Open Access Journals (Sweden)

    Siva Prasad

    2012-01-01

    Full Text Available Background: Acne vulgaris is a very common skin disease with a significant detrimental effect on the quality of life of the patients. Aims: To assess the comparative efficacy and safety of a nano-emulsion gel formulation of adapalene and clindamycin combination with its conventional formulation in the treatment of acne vulgaris of the face. It was a prospective, randomized, open label, active-controlled, multicentric, clinical trial. Methods: Eligible patients suffering from acne vulgaris of the face were randomized to receive once-daily treatment with a nano-emulsion gel or conventional gel formulation of adapalene 0.1% and clindamycin (as phosphate 1% combination for 12 weeks. Total, inflammatory and noninflammatory lesion counts, with grading of acne severity were carried out on a monthly basis. Safety assessments were done to determine the comparative local and systemic tolerability. Two-tailed significance testing was carried out with appropriate statistical tests, and P-values < 0.05 were considered as significant. Results: 209/212 patients enrolled in the study were eligible for efficacy and safety assessments in both nano-emulsion gel (118/119 patients and conventional gel (91/93 patients groups. Significantly better reductions in total (79.7% vs. 62.7%, inflammatory (88.7% vs. 71.4% and noninflammatory (74.9% vs. 58.4% lesions were reported with the nano-emulsion gel as compared to the conventional gel (P < 0.001 for all. Mean acne severity score also reduced significantly more with the nano-emulsion formulation (1.9 ± 0.9 vs. 1.4 ± 1.0; P < 0.001 than the comparator. Significantly lower incidence and lesser intensity of adverse events like local irritation (4.2% vs. 19.8%; P < 0.05 and erythema (0.8% vs. 9.9%; P < 0.05 were recorded with the nano-emulsion gel. Conclusions: The nano-emulsion gel formulation of adapalene and clindamycin combination appears to be more efficacious and better tolerated than the conventional formulation

  8. Effective Treatments of Atrophic Acne Scars

    OpenAIRE

    Gozali, Maya Valeska; ZHOU, BINGRONG

    2015-01-01

    Atrophic scarring is often an unfortunate and permanent complication of acne vulgaris. It has high prevalence, significant impact on quality of life, and therapeutic challenge for dermatologists. The treatment of atrophic acne scars varies depending on the types of acne scars and the limitations of the treatment modalities in their ability to improve scars. Therefore, many options are available for the treatment of acne scarring, including chemical peeling, dermabrasion, laser treatment, punc...

  9. Acne Scars

    Science.gov (United States)

    ... care Kids’ zone Video library Find a dermatologist Acne scars Overview Acne scar treatment: This woman's dermatologist ... At 3 months (right), she has noticeable improvement. Acne scars: Overview If acne scars bother you, safe ...

  10. EFFECT OF METHOD OF PREPARATION ON PHYSICAL PROPERTIES OF CIPROFLOXACIN HCL ELASTIC LIPOSOMES INTENDED TO BE UTILIZED IN TREATMENT OF ACNE VULGARIS

    Directory of Open Access Journals (Sweden)

    Raheem Saba Abdulridha

    2013-10-01

    Full Text Available Acne vulgaris usually associated with bacterial infections which develops antibiotic resistance in short time. To overcome the resistance, high dose of antibiotic must be directed toward the infected site for appropriate treatment period. For this reason, ciprofloxacin HCl in liposomes may have a chance to concentrate at hair follicles and sebaceous gland and treat skin infections and acne. Aim of this study was to find out the best formula in terms of entrapment efficiency and elasticity among the prepared formula in addition to find the effect of method of preparation on prepared liposomes. Multiple formulas were prepared using 100 mg of ciprofloxacin HCl, 700 mg of phospahtidylcholine with different concentrations of cholesterol (10, 20, 30 and 40 mg. Formulas contain 20 and 30 mg of cholesterol were selected to study the effect of sodium deoxycholate. Rotary evaporator and bath sonication methods were utilized to prepare liposomes. Liposomes properties as entrapment efficiency, vesicles size, relative deformability (elasticity and pH were studied. Regarding formulas prepared by rotary evaporator, formula which contains 30 mg cholesterol and 25 mg sodium deoxycholate has higher entrapment efficiency (77.24 %. While the highest entrapment efficiency (81.99 % was obtained from formula contain 20 mg cholesterol alone prepared by sonication method. Liposomes are relatively small in size and ranged between 8.89 - 89.9 microns. Sonication method gives liposomes with higher elasticity (relative deformability equal to 7 minutes for both formulas prepared by 20 mg cholesterol and 50 and 75 mg sodium deoxycholate respectively. No significant effect for method of preparation on pH of the formulas were observed as the pH values ranged between 4.4 - 5.5.

  11. Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: A randomized control trial

    Directory of Open Access Journals (Sweden)

    NilFroushzadeh Mohammad

    2009-01-01

    Full Text Available Background: Acne vulgaris is a common skin disease that affects 85% to 100% of people at some time during their lives. It is characterized by noninflammatory follicular papules or comedones and by inflammatory papules, pustules, and nodules in its more severe forms. Aims: To compare the efficacy of combination treatment of clindamycin+salicylic acid, versus clindamycin+tretinoin versus clindamycin alone in the treatment of the mild-to-moderate acne vulgaris. Methods: This was a single-blinded, randomized clinical trial.Forty-two female patients (age range: 15-25 years with mild-to-moderate acne vulgaris were selected randomly and subsequently randomized to 3 groups. Group A patients were treated with 1% clindamycin lotion (C lotion twice daily. Group B patients were treated with 1% clindamycin+0.025% tretinoin lotion once nightly (CT lotion. Group C patients were treated with 1% clindamycin+2% salicylic acid lotion twice daily (CS lotion for 12 weeks. For comparison of efficacy of these treatments, and regarding the skewed distribution of the data, Kruskal-Wallis Test and Mann-Whitney U test were used. SPSS software was used for statistical analysis. Results: There was a significant difference between 3 types of treatment in the respect of the total lesion count (TLC improvement ( P = 0.039. The efficacy of treatment on Acne Severity Index (ASI was maximum for CS lotion (81.80% reduction in ASI. CT lotion reduced ASI by as much as 73.73% during 12 weeks of treatment. The efficacy of C lotion was calculated to be 37.87% in the reduction of ASI. Conclusions: Our data suggested that the efficacy of CS lotion was significantly more than C lotion with respect to the TLC and ASI, although there was no significant difference between CS and CT lotion.

  12. Efficacy of Photodynamic Therapy in the Short and Medium Term in the Treatment of Actinic Keratosis, Basal Cell Carcinoma, Acne Vulgaris and Photoaging: Results from Four Clinical Trials

    Science.gov (United States)

    Martínez-Carpio, PA; Alcolea-López, JM; Vélez, M

    2012-01-01

    Objective: To determine the clinical efficacy of methyl-aminolevulinate (MAL)-Photodynamic Therapy (PDT) in the treatment of actinic keratosis (AK), basal cell carcinoma (BCC), acne vulgaris (AV) and photoaging (PA), in the short and medium term. Subjects and methods: Four separate prospective studies were designed on patients with AK (n=25), BCC (n=20), AV (n=20) and PA (n=25). Two PDT protocols were applied, and different clinical efficacy criteria were established, including lesion count and size. Two semi-quantitative and four analogue visual scales were completed for the evaluation of results according to the therapist, the patient and two independent experts. Results: In the AK and BCC studies, full clinical remission was observed in 84.7% and 75.7% of lesions, respectively. In the AV study, the number of inflammatory and non-inflammatory lesions fell significantly (pMAL-PDT procedures used produced efficacious, safe and satisfactory results in KA, BCC, AV and PA in the short and medium term. PMID:24511190

  13. The Association between Cigarette Smoking and Acne Intensity

    OpenAIRE

    Taheri Ramin; Nasaji Zavareh Mohammad; Ghorbani Raheb; Mohmmadi Zahra

    2009-01-01

    Background: Acne vulgaris is a common chronic inflammatory disease of pilosebaceous unit. Different factors have been suggested to influence acne including diet, menstruation and occupation. The role of some of these factors on acne intensity is confirmed. The affect of Cigarette smoking on acne intensity has been suggested. In this research, we evaluated the association between cigarette smoking and the acne intensity.Materials and Methods: This cross-sectional study was performed on 278 sm...

  14. Prevalence of acne in primary school children and the relationship of acne with pubertal maturation

    OpenAIRE

    Hilal Kaya Erdoğan; İlknur Kıvanç Altunay; Serap Turan

    2014-01-01

    Background and Design: Although acne vulgaris is generally regarded as a disease of adolescence period, it can occur in infancy, early childhood and prepubertal period. Acne may emerge as the first sign of pubertal maturation. In our study, we aimed to determine the acne prevalence in primary school children, then, evaluate the pubertal signs in those children; examine the correlation of the presence and severity of acne with pubertal signs, and finally, revise the concept of prepubertal a...

  15. Acne fulminans incapacitante Disabling Acne Fulminans

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    Tiago Pina Zanelato

    2011-08-01

    Full Text Available Acne fulminans é uma manifestação rara, que pode ocorrer durante a evolução da acne vulgar, principalmente, em adolescentes masculinos. Uso de isotretinoína, testosterona, e reações imunológicas exacerbadas no organismo são desencadeantes relacionados. Sinais, sintomas e alterações laboratoriais como: febre, hepatomegalia, poliartralgia, leucocitose, plaquetose, aumento de provas inflamatórias e transaminases, são característicos. A cintilografia óssea pode detectar lesões líticas em vários sítios do esqueleto. O tratamento é realizado com prednisolona, isotretinoína e antibióticos se infecções secundárias. Este caso relata um paciente masculino com diagnóstico de acne grau III, que desenvolveu acne fulminans e sacroileíte bilateral, com incapacidade de deambulação após início de terapia com isotretinoínaAcne fulminans is a rare manifestation that may occur during the evolution of acne vulgaris primarily in male adolescents. Use of isotretinoin, testosterone, and exacerbated immune responses in the body are related triggers. Signs, symptoms and laboratory findings such as fever, hepatomegaly, polyarthralgia, leukocytosis, plaquetose, increased inflammatory markers and transaminases, are characteristic. A bone scan can detect osteolytic lesions in multiple skeletal sites. The treatment is performed with prednisolone, isotretinoin and antibiotics if secondary infection is present. This case describes a male patient with a diagnosis of grade III acne, who developed acne fulminans and bilateral sacroiliitis with inability to ambulate, after initiation of therapy with isotretinoin

  16. Vulgaris

    Directory of Open Access Journals (Sweden)

    Mukaddes Kavala

    2012-01-01

    Full Text Available Background. Thyroid disorders may affect all of the organ systems of the body and they are also highly associated with a wide variety of skin disorders. The aim of this study was to investigate the prevalence of thyroid function abnormalities and thyroid autoimmunity in patients with pemphigus vulgaris (PV and to determine the association between thyroid disorders and clinical involvement and systemic corticosteroid treatment in patients with PV. Methods. The study consisted of eighty patients with PV and eighty healthy individuals. Thyroid functions (fT3, fT4, and TSH and thyroid autoimmunity (anti-thyroid peroxidase (anti-TPO, and anti-thyroglobulin (anti-Tg antibodies were investigated in both groups. Primary thyroid disease (PTD was diagnosed with one or more of the following diagnostic criteria: (i positive antithyroid antibodies, (ii primary thyroid function abnormalities. Results. Significant changes in the serum thyroid profile were found in 16% (13/80 of the PV group and 5% (4/80 of the control group. Positive titers of antithyroid antibodies (anti-TPO and anti-Tg were observed in 7 patients (9% with PV and one in the control group (1,2%. Hashimoto thyroiditis was diagnosed in 9% of PV patients and it was found to be more prevalent in the mucosal form of PV. PTD was found in 13 of (%16 PV patients which was significantly high compared to controls. PTD was not found to be associated with systemic corticosteroid use. Free T3 levels were significantly lower in PV group compared to the control group and free T4 levels were significantly higher in PV group compared to the controls. Conclusions. PV may exist together with autoimmune thyroid diseases especially Hashimoto thyroiditis and primer thyroid diseases. Laboratory work-up for thyroid function tests and thyroid autoantibodies should be performed to determine underlying thyroid diseases in patients with PV.

  17. Flavors disinfection decoction ingested orally plus topical treatment for 35 cases of acne vulgaris%五味消毒饮内服外敷治疗寻常性痤疮35例临床观察

    Institute of Scientific and Technical Information of China (English)

    游俊; 王英夫

    2012-01-01

    OBJECTIVE To observe the clinical efficacy of disinfection decoction taken orally and flavors used topically for the treatment of acne vulgaris. METHODS 60 cases of acne vulgaris were randomly divided into two groups: Treatment group 35 cases, disinfection decoction taken orally and flavors used topically. Control group 25 cases, oral ingestion of metronidazole tablets, vitamin A acid cream used topically before going to bed . RESULTS In treatment group, the recovery rate was 51.4%, the total effective rate was 97. 1 %. In control group, the basic recovery rate was 24.0%, the total effective rate was 80. 0%. The differences of recovery rate and the total effective rate between the two groups were significant differences (P< 0. 05). CONCLUSION Disinfection decoction taken orally and flavors used topically for the treatment of acne vulgaris has a significant effect, the security is good.%目的:观察五味消毒饮加减内服外敷治疗寻常性痤疮临床疗效.方法:60例痤疮患者随机分为两组,治疗组35例,采用五味消毒饮加减内服外敷联合治疗方法.对照组25例,口服甲硝唑片,睡前外用维A酸乳膏.结果:治疗组痊愈率51.4%.总有效率97.1%;对照组痊愈率24.0%.总有效率800.0%.两组痊愈率与总有效率比较,差异均有显著性(P<0.05).结论:五味消毒饮加减内服外敷法治疗寻常性痤疮有显著疗效,安全性好.

  18. Observation of curative effect by red-blue light combined with doxycycline in the treatment of acne ;vulgaris%红蓝光联合多西环素治疗寻常痤疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    种树彬

    2015-01-01

    Objective To observe clinical effect by red-blue light combined with doxycycline in the treatment of acne vulgaris. Methods A total of 120 acne vulgaris patients were randomly divided into treatment group and control group, with 60 cases in each group. The treatment group received red-blue light for radiation and oral administration of doxycycline. The control group received single doxycycline by oral administration. Their curative effects were compared. Results The treatment group had total effective rate as 83.3%, and the control group had that as 61.7%. It was better in the treatment group than the control group (P<0.05). Conclusion Implement of red-blue light combined with doxycycline in the treatment of acne vulgaris provides satisfactory effects, and this method is worthy of clinical promotion and application.%目的:观察红蓝光联合多西环素治疗寻常痤疮的临床疗效。方法120例寻常痤疮患者随机分为治疗组和对照组,各60例,治疗组采用红蓝光照射治疗,同时口服多西环素;对照组单独口服多西环素。对比两组疗效。结果治疗组总有效率为83.3%;对照组总有效率为61.7%,治疗组优于对照组(P<0.05)。结论红蓝光联合多西环素治疗寻常痤疮,疗效满意,值得临床推广应用。

  19. 红蓝光联合多西环素治疗寻常痤疮疗效观察%Observation of curative effect by red-blue light combined with doxycycline in the treatment of acne ;vulgaris

    Institute of Scientific and Technical Information of China (English)

    种树彬

    2015-01-01

    目的:观察红蓝光联合多西环素治疗寻常痤疮的临床疗效。方法120例寻常痤疮患者随机分为治疗组和对照组,各60例,治疗组采用红蓝光照射治疗,同时口服多西环素;对照组单独口服多西环素。对比两组疗效。结果治疗组总有效率为83.3%;对照组总有效率为61.7%,治疗组优于对照组(P<0.05)。结论红蓝光联合多西环素治疗寻常痤疮,疗效满意,值得临床推广应用。%Objective To observe clinical effect by red-blue light combined with doxycycline in the treatment of acne vulgaris. Methods A total of 120 acne vulgaris patients were randomly divided into treatment group and control group, with 60 cases in each group. The treatment group received red-blue light for radiation and oral administration of doxycycline. The control group received single doxycycline by oral administration. Their curative effects were compared. Results The treatment group had total effective rate as 83.3%, and the control group had that as 61.7%. It was better in the treatment group than the control group (P<0.05). Conclusion Implement of red-blue light combined with doxycycline in the treatment of acne vulgaris provides satisfactory effects, and this method is worthy of clinical promotion and application.

  20. New and emerging treatments in dermatology: acne.

    Science.gov (United States)

    Katsambas, A; Dessinioti, C

    2008-01-01

    Topical retinoids, benzoyl peroxide, azelaic acid, and topical and oral antibiotics remain the milestone of treatment for mild to moderate acne vulgaris. Oral isotretinoin is useful for the treatment of severe nodular acne, treatment-resistant acne, and acne with a risk of physical or psychological scarring. Hormonal treatment in female acne is useful in resistant or late-onset acne. With increasing concerns regarding teratogenicity of isotretinoin and increasing antibiotic resistance, there is a clear need for therapeutic alternatives to these long-used treatments. Research in the pathogenesis of acne has allowed for new therapies and future perspectives regarding acne to evolve. They include low-dose long-term isotretinoin regimens, insulin-sensitizing agents, 5alpha-reductase type 1 inhibitors, topical photodynamic therapy, new combination formulations, dietary interventions, and antiinflammatory agents such as lipoxygenase inhibitors. PMID:18394082

  1. Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes

    DEFF Research Database (Denmark)

    Kilian, Mogens; Scholz, Christian F. P.; Lomholt, Hans B.

    2012-01-01

    Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris, in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer...

  2. Multilocus Sequence Typing (MLST) and Phylogenetic Analysis of Propionibacterium acnes

    DEFF Research Database (Denmark)

    Kilian, Mogens; Scholz, Christian; Lomholt, Hans B

    2011-01-01

    Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris and in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer...

  3. Psychological impairments in the patients with acne

    OpenAIRE

    Behnaz Behnam; Ramin Taheri; Raheb Ghorbani; Peyvand Allameh

    2013-01-01

    Background: The psychological impacts of acne appearance and its-related negative emotional reactions have been proved; however, these reactions are varied in different populations. Aim: We investigated whether acne and its severity affected psychological functioning in those who suffered from this disorder among Iranians. Materials and Methods: One hundred and six patients with acne vulgaris who consecutively attended the dermatology outpatient clinics in Semnan city in 2008 were included. A...

  4. 红蓝光联合美满霉素治疗寻常痤疮临床疗效观察%Clinical observations on red-blue light combined with minomax in the treatment of acne vulgaris

    Institute of Scientific and Technical Information of China (English)

    沈娟; 张维娜; 张丹; 陈素琴

    2013-01-01

    目的评价红蓝光联合美满霉素治疗寻常痤疮的临床疗效及安全性。方法美满霉素100 mg每日1次,连服20 d;克林霉素甲硝唑搽剂外用,每日2次;红蓝光交替照射,每周2次,共4周。结果4周后治疗组痊愈率62.3%;总显效率89.1%。结论红蓝光联合美满霉素治疗寻常痤疮安全有效,患者满意度高。%Objective To evaluate the clinical efficacy and safety of joint red-blue light combined with minomax therapy for acne vulgaris. Methods Oral minomax 100mg daily and continued for 20 days. Topical clindamycin and metronidazole liniment, 2 times a day. Alternating red-blue light irradiation, 2 times a week for 4 weeks. Results After four weeks, the cure ratio was 62.3%in treatead patients, and the effective ratio was 89.1%. Conclusion Red-blue light combined with minomax therapy for acne vulgaris is safely and effectively, and patients have higher satisfactions with it.

  5. 针挑法结合维A酸类以及抗生素治疗痤疮疗效观察%Effect Observation of Needle Combined with Vitamin A Acid and Antibiotics in the Treatment of Acne Vulgaris

    Institute of Scientific and Technical Information of China (English)

    黄永辉

    2014-01-01

    目的:观察针挑痤疮内容物后应用维A酸类以及抗生素治疗痤疮的疗效和安全性。方法:治疗组70例,针挑痤疮内容物后,口服异维A酸胶丸或者维胺酯胶囊、单用或联合应用抗生素治疗;对照组67例,口服安体舒通片和单用或联合应用抗生素治疗;两组均外用治疗痤疮类乳膏。两组疗程均为6周。结果:治疗结束时两组有效率差异非常显著性(χ2=6.63,P<0.01)。结论:针挑法结合维A酸类以及抗生素治疗痤疮疗效好。%Objective:To observe the efficacy and safety of needle combined with vitamin A acid and antibiotics in the treatment of acne vulgaris. Methods:70 cases in the treatment group had oral vitamin A acid capsule or oral isotretinoin soft capsules, single or combined with antibiotic therapy with Viaminate capsules; 67 cases in the control group had oral administration of spironolactone and single or combined use of antibiotics; The two groups both had topical acne cream. The two groups were both treated for 6 weeks. Results:There was significant effective rate difference between the two groups(χ2= 6.63,P<0.01). Conclusion:The therapeutic effect of needle pricking method combined with vitamin A acid and antibiotics has good effect on the treatment of acne vulgaris.

  6. Multicenter study for efficacy and safety evaluation of a fixeddose combination gel with adapalen 0.1% and benzoyl peroxide 2.5% (Epiduo® for the treatment of acne vulgaris in Brazilian population*

    Science.gov (United States)

    Sittart, José Alexandre de Souza; da Costa, Adilson; Mulinari-Brenner, Fabiane; Follador, Ivonise; Azulay-Abulafia, Luna; de Castro, Lia Cândida Miranda

    2015-01-01

    BACKGROUND The current options for the treatment of acne vulgaris present many mechanisms of action. For several times, dermatologists try topical agents combinations, looking for better results. OBJECTIVES To evaluate the efficacy, tolerability and safety of a topical, fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel for the treatment of acne vulgaris in the Brazilian population. METHODS This is a multicenter, open-label and interventionist study. Patients applied 1.0 g of the fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel on the face, once daily at bedtime, during 12 weeks. Lesions were counted in all of the appointments, and the degree of acne severity, overall improvement, tolerability and safety were evaluated in each visit. RESULTS From 79 recruited patients, 73 concluded the study. There was significant, fast and progressive reduction of non-inflammatory, inflammatory and total number of lesions. At the end of the study, 75.3% of patients had a reduction of >50% in non-inflammatory lesions, 69.9% in inflammatory lesions and 78.1% in total number of lesions. Of the 73 patients, 71.2% had good to excellent response and 87.6% had satisfactory to good response. In the first week of treatment, erythema, burning, scaling and dryness of the skin were frequent complaints, but, from second week on, these signals and symptoms have reduced. CONCLUSION The fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel is effective, safe, well tolerated and apparently improves patient compliance with the treatment. PMID:27168522

  7. Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: a randomized, controlled trial.

    Science.gov (United States)

    Kwon, Hyuck Hoon; Yoon, Ji Young; Hong, Jong Soo; Jung, Jae Yoon; Park, Mi Sun; Suh, Dae Hun

    2012-05-01

    Recent studies have suggested that dietary factors, specifically glycaemic load, may be involved in the pathogenesis of acne. The aim of this study was to determine the clinical and histological effects on acne lesions of a low glycaemic load diet. A total of 32 patients with mild to moderate acne were randomly assigned to either a low glycaemic load diet or a control group diet, and completed a 10-week, parallel dietary intervention trial. Results indicate successful lowering of the glycaemic load. Subjects within the low glycaemic group demonstrated significant clinical improvement in the number of both non-inflammatory and inflammatory acne lesions. Histopathological examination of skin samples revealed several characteristics, including reduced size of sebaceous glands, decreased inflammation, and reduced expression of sterol regulatory element-binding protein-1, and interleukin-8 in the low glycaemic load group. A reduction in glycaemic load of the diet for 10 weeks resulted in improvements in acne. PMID:22678562

  8. [Acne tarda. Acne in adults].

    Science.gov (United States)

    Jansen, T; Janßen, O E; Plewig, G

    2013-04-01

    Acne is one of the most common skin diseases in the general population, especially among adolescents. Acne tarda (adult acne) is defined as acne that develops (late-onset acne) or continues (persistent acne) after 25 years of age. The disease is more common in women. The clinical features are quite specific: inflammatory acne in the lower facial region or macrocomedones (microcysts) spread over the face. Involvement of the trunk is much more common in men. The etiology of acne tarda is still controversial, as cosmetics, drugs, smoking, stress, diet, and endocrine abnormalities have been implicated. Women with acne tarda and other symptoms of hyperandrogenism have a high probability of endocrine abnormalities such as polycystic ovary syndrome. Treatment is similar to that of acne in adolescence. Long-term treatment over years or decades may be required. PMID:23576169

  9. Serum testosterone, DHEA-S and androstenedione levels in acne

    OpenAIRE

    Hatwal A; Singh S; Agarwal J; Singh G.; Bajpai H; Gupta S

    1990-01-01

    Basal serum levels of total testosterone, dehydroepiandosterone sulfate (DHEA, - S) and androstenedione (A4) were measured by radioimmunoassay in 100 patients of acne vulgaris, and in 100 age and sex matched acne free healthy subjects. In males with acne the mean serum testosterone levels were marginally and the DHEAS and A4A levels were significantly higher as compared to controls (p). Females with acne had significantly higher levels of testosterone (p< 0.001), DHEA-S (p< 0.001) and...

  10. A Four-question Approach to Determining the Impact of Acne Treatment on Quality of Life

    OpenAIRE

    Saitta, Peter; Grekin, Steven K.

    2012-01-01

    Facial acne vulgaris can have profound effects on health-related quality of life. In some studies, patients with acne vulgaris reported results similar to those noted with other chronic diseases, such as asthma, arthritis, or diabetes. Clinical objective assessments alone do not adequately capture the impact of acne vulgaris severity from a patient’s perspective. Health-related quality-of-life assessment is important in order to fully characterize the overall burden of disease and effectivene...

  11. A 6% Benzoyl Peroxide Foaming Cloth Cleanser Used in the Treatment of Acne Vulgaris: Aesthetic Characteristics, Patient Preference Considerations, and Impact on Compliance with Treatment

    OpenAIRE

    Del Rosso, James Q.

    2009-01-01

    Objective: The study was conducted to evaluate the product attributes of a new benzoyl peroxide-containing foaming cloth cleanser and to compare the overall patient satisfaction of this product with two currently available benzoyl peroxide acne products (6% benzoyl peroxide cleanser and 4% benzoyl peroxide wash). Design: This was a randomized, single-blind study. Setting: Two clinical trial sites. Participants: Male and female subjects (N=193) aged 17 to 30 years with a history of acne vulgar...

  12. DEVELOPMENT OF HERBAL ANTI ACNE GEL AND ITS EVALUATION AGAINST ACNE CAUSING BACTERIA PROPIONIBACTERIUM ACNE AND STAPHYLOCOCCUS EPIDERMIDIS

    Directory of Open Access Journals (Sweden)

    Daud Farhat S.

    2013-10-01

    Full Text Available Acne by definition is multifactorial chronic inflammatory disease of pilosebaceous units. Propionibacterium acnes and Staphylococcus epidermidis are considered as the major skin bacteria that cause the formation of acne. Although acne does not pose serious threat to general health, it is one of the most socially distressing conditions especially for adolescents. The objective of this study was to design a product to treat Acne with purely herbal actives as an effective and safe alternative to harmful antibiotics. For this purpose three essential oils and two herbal extracts having anti-microbial properties were selected. These were incorporated in a Gel Base in different concentrations and the in vitro antibacterial activity for the different formulations (F1, F2, F3 was studied against Propionibacterium acnes (P. acnes and Staphylococcus epidermidis (S.epidermidis, a causative organism for Acne vulgaris using Agar Well Diffusion method. All the formulations showed satisfactory Anti-microbial activity with Formulation F3 showing highest activity. It was then subjected to stress testing for three months at various temperatures. The samples were found to be stable after three months of stability studies and showed satisfactory antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis at the end of the stress testing studies. Thus it was concluded that the formulated Herbal Anti Acne Gel with natural actives can be used effectively for treating acne on skin.

  13. Psychological Impact of Isotretinoin Treatment in Patients with Moderate and Severe Acne

    OpenAIRE

    Šimić, Dubravka; Šitum, Mirna; Letica, Edita; Zeljko Penavić, Jasna; Vurnek Živković, Maja; Tomić, Teo

    2009-01-01

    Acne patients are subject to different degree of psychosocial distress. The emotional impact of acne vulgaris due to disfigurement caused by the disease is undisputed. Most common reactions to the acne are depression and anxiety. The use of isotretinoin, one of the most effective options in acne treatment, increases depression symptoms. The aim of this study was to investigate the psychological status of the patients with moderate to severe acne and to compare patients treated with isotretino...

  14. In-vivo fluorescence detection and imaging of porphyrin-producing bacteria in the human skin and in the oral cavity for diagnosis of acne vulgaris, caries, and squamous cell carcinoma

    Science.gov (United States)

    Koenig, Karsten; Schneckenburger, Herbert; Hemmer, Joerg; Tromberg, Bruce J.; Steiner, Rudolf W.

    1994-05-01

    Certain bacteria are able to synthesize metal-free fluorescent porphyrins and can therefore be detected by sensitive autofluorescence measurements in the red spectral region. The porphyrin-producing bacterium Propionibacterium acnes, which is involved in the pathogenesis of acne vulgaris, was localized in human skin. Spectrally resolved fluorescence images of bacteria distribution in the face were obtained by a slow-scan CCD camera combined with a tunable liquid crystal filter. The structured autofluorescence of dental caries and dental plaque in the red is caused by oral bacteria, like Bacteroides or Actinomyces odontolyticus. `Caries images' were created by time-gated imaging in the ns-region after ultrashort laser excitation. Time-gated measurements allow the suppression of backscattered light and non-porphyrin autofluorescence. Biopsies of oral squamous cell carcinoma exhibited red autofluorescence in necrotic regions and high concentrations of the porphyrin-producing bacterium Pseudomonas aerigunosa. These studies suggest that the temporal and spectral characteristics of bacterial autofluorescence can be used in the diagnosis and treatment of a variety of diseases.

  15. Hubungan Stres dengan Kejadian Akne Vulgaris Di kalangan Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Angkatan 2007-2009

    OpenAIRE

    Perumal, Nitya

    2011-01-01

    Background: Acne or acne vulgaris has always been well concerned among teenagers and adolescent age. Acne vulgaris is a common disorder of the follicle sebaceous unit that predominantly occurs in adolescence. Acne vulgaris which is suffered by 95 to 100 percent boys and 83 to 85 percent girls. This skin disease is caused by multifactoral of skin disease, which is stress. With the increased studying burden, packed time table and inadequate sleep has caused medical students in University of Nor...

  16. Clinical therapeutic effect of herbal facial mask combined with adapalene gel in treatment of acne vulgaris%中药面膜联合阿达帕林凝胶治疗寻常痤疮的临床观察

    Institute of Scientific and Technical Information of China (English)

    江从军; 金慧玲

    2014-01-01

    目的:评价中药面膜联合0.1%阿达帕林凝胶治疗轻、中度寻常痤疮的临床疗效及安全性。方法寻常痤疮76例,随机分为两组,治疗组40例,采用中药面膜联合0.1%阿达帕林凝胶治疗;对照组36例,单独使用0.1%阿达帕林凝胶治疗。两组均在治疗6周后观察疗效并评价安全性。结果试验组、对照组的总有效率在第6周时分别为82.5%和52.7%,具有明显的差异。在治疗过程中,两组均未见明显不良反应。结论中药面膜联合0.1%阿达帕林凝胶治疗轻、中度寻常痤疮较单用阿达帕林疗效显著,见效快,病程短,无明显不良反应。%Objective To evaluate the clinical efficacy and safety of the combination therapy of herbal facial mask with 0.1%adapalene gel in patients with mild and moderate acne vulgaris .Methods A total of 76 patients with mild to moderate acne vulgaris were enrolled and randomly divided into 2 groups:40 cases in treatment group which were treated by herbal facial mask combined with 0.1%adapalene gel;36 cases in control group which were treated only by 0.1%adapalene gel .All the patients received therapy for 6 weeks continuously and had been observed to evaluate the efficacy and safety on the sixth week of treatment .Results On the sixth week of treatment, the total effective rate of treatment group was 82.5%, and there was a significant difference compared with the control group ( 52.7%) .All these 2 groups had not obvious side-effect during treatment . Conclusions Herbal facial mask combined with 0.1% adapalene gel therapy is more effective than adapalene monotherapy in mild to moderate acne cases with a rapid response and similar adverse reactions .

  17. Estudo clínico aberto multicêntrico da efetividade e tolerabilidade do gel de adapaleno a 0,1%* em pacientes com acne vulgar Multicentric open clinical study of the efficacy and tolerability of adapalene 0.1% gel* in patients with acne vulgaris

    Directory of Open Access Journals (Sweden)

    Marcia Ramos-e-Silva

    2003-04-01

    Full Text Available FUNDAMENTOS: O adapaleno é um derivado do ácido naftóico, com propriedades biológicas similares às do ácido retinóico e utilizado no tratamento da acne vulgar. OBJETIVOS: Avaliar a eficácia e a tolerabilidade do adapaleno 0,1% gel no tratamento da acne vulgar leve à moderada, em pacientes residentes no Brasil. MATERIAIS E MÉTODOS: Os pacientes aplicaram o gel à noite, durante 12 semanas, e foram avaliados quanto à efetividade pelo número de lesões em cada visita e quanto à tolerabilidade ao produto nas consultas da segunda e da décima segunda semana. RESULTADOS: Dos 125 pacientes, 81,6% completaram as 12 semanas de tratamento, e 10,4% dos casos terminaram o estudo antes do período estabelecido por estarem livres de lesões. Os resultados permitem confirmar a marcante atividade antiinflamatória, antiproliferativa e na diferenciação celular dos ceratinócitos. Houve diminuição dos comedões e das lesões inflamatórias, com resposta satisfatória no eritema, no ressecamento e na descamação da pele. Efeitos adversos pouco graves foram relatados em apenas 9,6% dos pacientes. CONCLUSÕES: O adapaleno, neste estudo e nos vários que o antecederam, vem-se mostrando uma das melhores opções de tratamento tópico para os casos leves a moderados de acne vulgar.BACKGROUND: Adapalene, a naftoic acid derivative with biological properties similar to those of the retinoic acid, is indicated in the treatment of acne vulgaris. OBJECTIVES: The present study was carried out to evaluate the therapeutic action of adapalene 0.1% gel and its tolerability in the treatment of mild to moderate acne vulgaris in patients living in Brazil. MATERIAL AND METHODS: Patients applied the gel at night for 12 weeks; and were evaluated regarding the efficacy and tolerability of the product according to the number of lesions observed at each of the 2-week and 12-week visits. RESULTS: Out of 125 patients, 81.6% completed 12 weeks of therapy and 10.4% of the

  18. Qingdou Xiufu Jinghua Ye for the improvement of acne vulgaris: a multi-center study%清痘修复精华液改善寻常痤疮皮损的多中心研究

    Institute of Scientific and Technical Information of China (English)

    徐良恒; 李娜; 程波; 李惠; 林新瑜; 范文葛; 黄一锦; 曹萍; 孙东杰

    2013-01-01

    目的 探讨含重楼、马齿苋提取物、透明质酸钠的清痘修复精华液改善寻常痤疮的安全性.方法 多中心、随机、开放对照研究,分为观察组及对照组各80例.每天早晚各1次,在使用薇诺娜洁面泡沫清洁面部后,观察组在痤疮皮损处使用含重楼、马齿苋提取物、透明质酸钠的清痘修复精华液,对照组在皮损处外用含木瓜蛋白酶活性成分、维生素B3、马齿苋提取液、水杨酸衍生物的薇诺娜清痘修复精华液.分别观察观察组和对照组使用前后皮损改善情况.结果 共完成149例,脱落11例,完成实验中,观察组73例,对照组76例.使用受试品14 d,28 d,使用前后炎性皮损及总皮损数较首诊日均有明显改善(P<0.05),观察组与对照组有效率比较,差异无统计学意义.结论 含重楼、马齿苋提取物、透明质酸钠的清痘修复精华液能辅助改善痤疮皮损.%Objective To evaluate the safety of Qingdou Xiufu Jinghua Ye,a skin care product containing the extract of Chinese manyleaf paris rhizome,purslane and sodium hyaluronate,in the improvement of acne vulgaris.Methods A multicenter,randomized,open-label,controlled study was conducted.Totally,160 patients with acne vulgaris were equally classified into two groups to topically apply the modified Qingdou Xiufu Jinghua Ye containing the extract of Chinese manyleaf paris rhizome,purslane and sodium hyaluronate (experiment group) or the original Qingdou Xiufu Jinghua Ye containing papain,vitamin B3,extract of purslane,and salicylic acid derivate (control group),twice a day after face washing with a commercial foaming face wash.The number of acne lesions was calculated at the baseline,on day 7,14 and 28 after the start of intervention.Results Finally,11 patients were lost to follow-up,and 149 patients completed the trial,including 73 patients in the experiment group and 76 patients in the control group.The number of inflammatory lesions and total lesions

  19. Observation of clinical efficacy of red blue light irradiation for 198 cases of acne vulgaris%红蓝光照射治疗198例痤疮的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    姬静静; 杨卫涌; 朱洁丽; 安永涛

    2015-01-01

    目的:观察红蓝光照射治疗痤疮的临床疗效.方法:将198例痤疮患者随机分为治疗组和对照组,对照组给予丹参酮胶囊口服,克林霉素磷酸酯凝胶外敷.治疗组除给予以上药物外,配合红蓝光交替照射面部痤疮部位.一个月后对两组患者疗效进行评价.结果:治疗组治愈率为45.9%,显效率为30.6%,对照组治愈率为31.0%,显效率为21.0%,X2=9.87,P<0.05,差异明显.结论:红蓝光交替照射治疗痤疮疗效显著,临床上可以推广使用.%Objective: To observe the clinical effect of red blue light irradiation in the treatment of acne.Methods: 198 cases of patients with acne were randomly divided into the treatment group and the control group, the control group was given oral Danshentong capsule, clindamycin phosphate gel for external application. In addition to the treatment group to give the above, with the red blue light irradiation of facial acne. After a month, the efficacy of the two groups of patients were evaluated.Results: the cure rate of the treatment group was 45.9%, the cure rate was 30.6%, the cure rate was 31% in the control group, 21% in the control group, X2 = 9.87, P < 0.05, the difference was obvious. Conclusion: red and blue light irradiation in the treatment of acne vulgaris is effective, can be used in clinic.

  20. Efficacy of oral antibiotics on acne vulgaris and their effects on quality of life: a multicenter randomized controlled trial using minocycline, roxithromycin and faropenem.

    Science.gov (United States)

    Hayashi, Nobukazu; Kawashima, Makoto

    2011-02-01

    There are few clinical studies which compare the efficacy and patient satisfaction for oral antibiotics to treat inflammatory acne. To clarify the difference between oral antibiotics, acne patients with moderate to severe inflammatory eruptions were randomized into three groups, and each patient was given minocycline (MINO), roxithromycin (RXM) or faropenem (FRPM) for 4 weeks, followed by 4 weeks of observation without any oral antibiotics. We estimated the reduction rate of inflammatory lesion counts, the scale of Skindex-16 which represents patient quality of life (QOL), and minimum inhibitory concentrations required to inhibit the growth of 90% of Propionibacterium acnes isolated from acne patients (MIC(90) ). In all three groups, inflammatory lesion counts, and emotional and total score of Skindex-16 were significantly improved (P<0.05) after 4 weeks treatment, and these effects were maintained for the following 4 weeks. Dizziness/nausea in two patients (4.1%) of the MINO group and diarrhea in three patients (5.9%) of the FRPM group were observed. There was no significant difference of percentage reduction in inflammatory lesion counts and incident rates of side-effects between these three oral antibiotics. MIC(90) of MINO was 0.25 μg/mL before and after treatment, but MIC(90) of RXM had increased from 0.25 μg/mL to more than 32 μg/mL after treatment. MIC(90) of FRPM was 0.06 μg/mL or less for all strains before and after treatment. Our randomized controlled clinical trial suggested that MINO, RXM and FRPM were efficient to improve inflammatory acne and patient QOL, and there was no significant difference between them. PMID:21269305

  1. Laser and light based treatments of acne

    OpenAIRE

    Reena Rai; Karthika Natarajan

    2013-01-01

    Medical treatments for acne vulgaris include a variety of topical and oral medications. Poor compliance, lack of durable remission, and potential side effects are common drawbacks to these treatments. Therefore, there is a growing demand for a fast, safe, and side-effect-free novel therapy. Acne often improves after exposure to sunlight, and this has led to the development of laser and other light therapies resulting in the overall ease of treatment, with minimal adverse effects. A variety of...

  2. Treatment of Acne in Pregnancy.

    Science.gov (United States)

    Chien, Anna L; Qi, Ji; Rainer, Barbara; Sachs, Dana L; Helfrich, Yolanda R

    2016-01-01

    Acne vulgaris is a common disease of the pilosebaceous unit and affects adolescents and adults. Because high-quality guidelines regarding treatment of acne in pregnancy are scarce, management of this condition can be challenging. We describe the safety profile of common therapies and outline approaches based on available evidence. Topical azelaic acid or benzoyl peroxide can be recommended as baseline therapy. A combination of topical erythromycin or clindamycin with benzoyl peroxide is recommended for inflammatory acne. Oral erythromycin or cephalexin is generally considered safe for moderate to severe inflammatory acne when used for a few weeks. A short course of oral prednisolone may be useful for treating fulminant nodular cystic acne after the first trimester. In general, topical and oral antibiotics should not be used as monotherapy, but combined with topical benzoyl peroxide to decrease bacterial resistance. Oral retinoids are teratogenic and absolutely contraindicated for women who are pregnant or considering pregnancy. Although some complementary therapies including micronutrients and nonpharmacologic treatments seem to be well tolerated, limited data exist regarding their safety and efficacy, and they are not currently recommended during pregnancy. The risk-to-benefit ratio, efficacy, acceptability, and costs are considerations when choosing a treatment for acne in pregnancy. PMID:26957383

  3. Anxiety, depression, social phobia, and quality of life in Turkish patients with acne and their relationships with the severity of acne

    OpenAIRE

    Ahmet ÖZTÜRK; DEVECİ, Erdem; BAĞCIOĞLU, Erman; Atalay, Figen; Serdar, Zehra

    2013-01-01

    To investigate the psychiatric characteristics of acne vulgaris and the effects of the disease on quality of life. Materials and methods: We included 70 acne patients and 50 healthy controls. The Structured Clinical Interview for DSM-IV Axis I Disorders, Hospital Anxiety and Depression Scale, Liebowitz Social Anxiety Scale, Quality of Life Scale Short Form, and Acne Quality of Life Questionnaire were applied. Results: Anxiety and depression scores of the acne patients were significantly h...

  4. Carrier-Based Drug Delivery System for Treatment of Acne

    OpenAIRE

    Amber Vyas; Avinesh Kumar Sonker; Bina Gidwani

    2014-01-01

    Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of...

  5. Etiopathogenesis and Therapeutic Approach to Adult Onset Acne.

    Science.gov (United States)

    Kaur, Sarabjit; Verma, Poonam; Sangwan, Ankita; Dayal, Surabhi; Jain, Vijay Kumar

    2016-01-01

    Acne vulgaris is usually considered as a skin disorder that primarily affects adolescents reaching a peak at the age of 14-17 years in females and 16-19 years in males. However, recent epidemiologic studies have shown that a significant number of female patients aged >25 years experience acne. As it is regarded as a disease of teenagers, adults are more apprehensive and experience social anxiety. Hence, adult onset acne has become a matter of concern. PMID:27512185

  6. Multilocus Sequence Typing and Phylogenetic Analysis of Propionibacterium acnes

    OpenAIRE

    Kilian, Mogens; Scholz, Christian F. P.; Hans B Lomholt

    2012-01-01

    Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris, in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer. As the species includes evolutionary lineages with distinct association with health and disease, there is a need for a high-resolution typing scheme. Recently, two multilocus sequence typing (MLST) scheme...

  7. 抗雄激素疗法治疗痤疮的进展%Anti-androgen treatment of acne vulgaris: an update

    Institute of Scientific and Technical Information of China (English)

    刘晔; 项蕾红

    2012-01-01

    雄激素在痤疮发生过程中起着重要的作用,对于抗生素和维A酸类药物反应不佳的女性患者而言,无论其血雄激素水平是否正常,联合使用抗雄激素疗法可能是一种理想的选择,但具体机制尚不明确.抗雄激素疗法的药物可分为以下4类:雄激素受体拮抗剂、肾上腺源性雄激素阻断剂、卵巢源性雄激素阻断剂、酶抑制剂.外用抗雄激素制剂可能成为新的研究方向.概述抗雄激素治疗痤疮的机制、治疗方法以及新的研究进展.%Androgen plays an essential role in the pathophysiology of acne.The combination with antiandrogen agents may be an ideal option for the treatment of female patients with acne who poorly respond to antibiotics and tretinoins regardless of their blood level of androgens,although the exact therapeutic mechanism has not been well understood up to now.Anti-androgen agents can be classified into 4 groups,i.e.,androgen receptor antagonists,adrenal gland-derived inhibitors on androgen production,ovary-derived inhibitors on androgen production,and enzyme inhibitors.Topical anti-androgen agents may become a hot spot in future research on the treatment of acne.This paper presents the advances in therapeutic mechanisms and modalities of anti-androgen treatment of acne.

  8. Blue-red light and intense pulsed phototherapy combination therapy of acne vulgaris clinical observation%红蓝光与强脉冲光联合治疗痤疮的疗效观察

    Institute of Scientific and Technical Information of China (English)

    赵娜; 党辉; 李薇

    2012-01-01

    目的:探讨红蓝光与强脉冲光联合应用治疗痤疮的疗效.方法:青年痤疮患者60例,将其随机分为红蓝光组、强脉冲光组及联合治疗组,行相应治疗并评价其疗效,在治疗期间及治疗后3个月内,对患者进行进行随访并观察不良反应发生情况,治疗后从自我感知、社会与情感功能、痤疮症状三个维度评价其生活质量的变化.结果:在治疗2周和4周后,联合治疗组患者GAGS评分高于其他两组,其差异无统计学意义(P>0.05).在治疗全程及治疗后3个月内,联合治疗组患者不良反应发生率低于其他两组,其差异有统计学意义(P<0.05).在对患者生活质量的研究中,联合治疗组患者在自我感知、社会与情感功能、痤疮症状三个维度皆表现出了更积极的效果,其差异有统计学意义(P<0.05).结论:联合应用红蓝光与强脉冲光治疗痤疮,在保证治疗效果的同时,可以降低不良反应发生率,并提高青年患者生活质量,对痤疮治疗有重要意义.%Objective To observe the therapeutic effect of Blue-red light and intense pulsed phototherapy combination therapy of acne vulgaris. Methods 60 cases were randomly divided into three groups,20 cases in each group. Every group received the consistent treatment means. Aim to evaluate the clinical efficacy for acne vulgaris, compare GAGS score difference among the three groups at the 2 and 4 weeks after the beginning of the treatment. Aim to evaluate the incidence of adverse reactions, We arranged the 30 follow-up investigation of adverse reactions for comparing the difference of their incidence of adverse reactions. At the same time, we compared the change in the quality of life from the self-perception, social and emotional function and the acne symptoms. Results The therapeutic effects in the combination group were significantly as well as the two other groups (P>0.05). However, it has lower incidence of adverse reactions(P<0.05), and

  9. 肤痔清软膏在中重度寻常痤疮患者中的应用%Application of Fuzhiqing ointment in the treatment of moderate to severe acne vulgaris

    Institute of Scientific and Technical Information of China (English)

    梁国雄; 胡宝婵; 余嘉明; 王俊秀

    2014-01-01

    Objective To investigate the application of Fuzhiqing ointment in the treatment of moderate to severe acne vulgaris. Methods 400 patients with moderate to severe acne vulgaris were randomly divided (100 cases each) into topical group (Fuzhiqing ointment for topical use), routine group (routine oral drugs), combination group (Fuzhiqing ointment and routine oral drugs) and mask group (routine oral drugs and Fuzhiqing ointment used for fa-cial mask). Efficacy and adverse reactions were observed for 4 weeks. Results There was no statistical difference of effective rate between topical group and routine group. The effective rate of combination group was higher than that of topical group. The effective rate of mask group was 87%, which was higher than those of other groups and all the dif-ferences were statistical significant. 4 patients felt mild epigastric discomfort and 1 patient in mask group had mild fa-cial flushing and burning. All these adverse reactions needed no treatment. Conclusion For treating patients with moderate to severe acne vulgaris, Fuzhiqing ointment has the advantages of good efficacy and high safety. It was bet-ter when performed with facial mask combined with routine treatment. It was worthy of clinical popular application.%目的:探讨肤痔清软膏对中重度寻常痤疮的临床治疗作用。方法400例中重度寻常痤疮患者随机分为外用组(只外涂肤痔清软膏)、常规组(常规口服药物治疗)、联合组(常规口服药物联合外涂肤痔清软膏)和倒膜组(常规口服药物联合外涂肤痔清软膏和面部倒膜治疗)各100例,给予相应治疗4周,观察疗效和不良反应。结果外用组与常规组的有效率差异无统计学意义(P>0.05),联合组的有效率优于外用组,倒膜组的有效率为87.00%,优于其余各组,其差异均有统计学意义(P<0.05)。有4例患者出现轻微上腹部不适,倒膜组有1例患者出现面部轻微潮红和烧灼感

  10. 一清胶囊联合盐酸多西环素胶囊治疗痤疮疗效观察%Effect Observation of YiQing Capsules Combined with Doxycycline Hydrochl-oride Capsule on Acne Vulgaris

    Institute of Scientific and Technical Information of China (English)

    王宝庭

    2011-01-01

    Objective To investigate the effects of doxycycline hydrochloride capsules combined with YiQing capsules on acne vulgaris.Methods One handred cases of acne vulgaris were randomly divided into three groups:combination treatment group (34 cases)were treated with doxycycline hydrochloride capsules 100mg, 2 times/d and YiQing capsules 3 times after the food, for 21 days; doxycycline hydrochloride group (34 cases)were treated with doxycycline hydrochloride capsules 100mg, 2times/d after the food for 21 days,Yiqing capsules group (32 cases) YiQing capsules 3 times/d, after the food for 21 days.Results The clinical cure rate of combination treatment group,doxycycline hydrochloride group, Yiqing capsules group were 52.90%,35.30% ,31.25% ,and the total effective rate were 94.10% ,61.80% ,59.38%.Total effectiveness of Doxycycline Hydrochloride group and Yiqing Capsules group were significant difference between combination treatment group ( P < 0.05 ).The Doxycycline Hydrochloride group and Yiqing Capsules group were no significant difference( P > 0.05 ).The combination treatment group without obvious adverse reactions.Conclusion YiQing Capsules combined with Doxycycline Hydrochloride capsules for the treatment of acne vulgaris effective, few side-effect.%目的 评价一清胶囊联合盐酸多西环素胶囊治疗寻常性痤疮的疗效.方法 将100例寻常性痤疮患者随机分为3组.联合治疗组34例,予盐酸多西环素胶囊100mg饭后服,2次/d,一清胶囊饭后口服2粒,3次d,共21天;多西环素组34例,单纯口服多西环素;一清胶囊组32例,单纯口服一清胶囊,用法和用量均同联合治疗组.结果 治疗结束后,联合治疗组、多西环素组及一清胶囊组的痊愈率分别为52.90%,35.30%和31.25%,有效率分别为94.10%,61.80%和59.38%.多西环素组及一清胶囊组的有效率均低于联合治疗组,差异有统计学意义(P均0.05).联合治疗组无明显不良反应.结论 一清胶囊联合盐酸

  11. Responsiveness of the Dermatology-specific Quality of Life (DSQL) instrument to treatment for acne vulgaris in a placebo-controlled clinical trial.

    Science.gov (United States)

    Anderson, R; Rajagopalan, R

    1998-12-01

    The Dermatology-specific Quality of Life (DSQL) instrument is a new tool which has been developed to address the effects of skin disease and its treatment on physical and social functioning and self-perceptions. Previous reports have demonstrated its cross-sectional validity. The current study examines the DSQL's responsiveness to 12 weeks of acne treatment in a placebo-controlled randomized clinical trial. The DSQL change scores were moderately correlated (r = 0.18 to 0.37) with treatment efficacy parameters including: dermatologist's rating of improvement of acne and a skin irritation score, and highly correlated with patient's global rating of acne severity. Within treatment groups, the DSQL discriminated clinically meaningful changes associated with small and moderate effect sizes. The DSQL total score showed statistically significant differences on nearly all comparisons with placebo. The DSQL dimension scores were sensitive to the most effective therapy compared to placebo. Responsiveness benchmarks are provided for small and moderatesized treatment effects. As a comprehensive instrument, the DSQL is a practical and psychometrically sound tool for use in clinical trials in dermatology. PMID:10097621

  12. 红蓝光联合治疗面部寻常性痤疮的临床观察%Clinical comparative observation of red and blue light combination phototherapy in the treatment of acne vulgaris

    Institute of Scientific and Technical Information of China (English)

    潘敏; 林向飞; 朱晓芳

    2014-01-01

    Objective To evaluate the efficacy of red and blue light combination phototherapy in the treatment of acne vulgaris. Methods The acne patients were treated with red and blue light combination phototherapy twice a week for four weeks.The number of inflammatory lesions (papules, pustules,nodules and cysts),non - inflammatory lesions (comedones)and the total number were counted to evaluate the improvement rates. Results After the treatment,the patients got 60.00%improvement.Mean improvements rates after the final treatment in non- inflammatory and inflammatory lesions were 55.70%and 70.04%,respectively,which has significant difference. In the process of treatment no obvious side effects was observed. Conclusion Red and blue light is an effective therapy for inflammatory and non- inflammatory lesions with mild side effects.%目的:观察和评价红蓝光联合治疗面部寻常性痤疮的疗效。方法:应用红蓝光联合治疗40例面部寻常性痤疮患者,每周2次,共治疗8次。结果:总有效率为60.00%。非炎性及炎性皮损平均改善率分别为55.57%和70.04%,两者差异具有统计学意义,未见明显不良反应。结论:红蓝光治疗痤疮,对炎症型皮损及非炎症型皮损均有良好的治疗效果,不良反应少,患者依从性良好。

  13. Psychological impairments in the patients with acne

    Directory of Open Access Journals (Sweden)

    Behnaz Behnam

    2013-01-01

    Full Text Available Background: The psychological impacts of acne appearance and its-related negative emotional reactions have been proved; however, these reactions are varied in different populations. Aim: We investigated whether acne and its severity affected psychological functioning in those who suffered from this disorder among Iranians. Materials and Methods: One hundred and six patients with acne vulgaris who consecutively attended the dermatology outpatient clinics in Semnan city in 2008 were included. Among them, 103 patients met the study′s inclusion criterion and agreed to participate. One hundred and six age and gender cross-matched healthy volunteers were included as controls that attended the clinic with their diseased relatives. All acne patients were evaluated using the Symptom Check List-90 (SCL-90. Results: According to the American Academy of Dermatology classification, 25.2% of the patients had mild acne, 50.5% moderate acne, and 24.3% severe acne. A higher percentage of participants than controls required further evaluation and psychological consultant when studying each psychological problem. The most common psychological symptoms requiring treatment due to disturbed daily activities in acne group were psychoticism (34.0% and depression (31.1%, respectively. Significant positive correlations were observed between the duration of illness and SCL-90 total score. When evaluating the SCL-90 scores, patients with multiple sites of involvement were affected more severely than those with a single site of involvement. Conclusion: Acne vulgaris has significant effects on psychological status. Effective concomitant anti-acne therapy and psychological assessment make significant contributions for the mental health and should be strongly recommended.

  14. Systematic review on the rapidity of the onset of action of topical treatments in the therapy of mild-to-moderate acne vulgaris.

    Science.gov (United States)

    Jacobs, A; Starke, G; Rosumeck, S; Nast, A

    2014-03-01

    The time until a patient achieves a relevant improvement during the treatment of a skin disease is important for selecting a therapy, but has been largely neglected in reviews and guidelines. The aim of this systematic review was to determine the time until the onset of action (TOA) of topical acne treatments. The primary outcome was the TOA defined as the time until a 25% reduction in the mean number of inflammatory lesions had been achieved. A systematic literature search in Medline and Embase was carried out. Clinical trials that evaluated head-to-head comparisons of treatments in patients suffering from mild-to-moderate papulopustular acne were included. Abstract and full-text screening and data extraction were done independently by two investigators. With respect to inflammatory lesions, different concentrations of benzoyl peroxide (BPO) or adapalene did not seem to influence the TOA. BPO seemed to act more quickly than isotretinoin and tretinoin. Adapalene showed a shorter TOA than isotretinoin. Conflicting results were seen when comparing adapalene with tretinoin, with a tendency for adapalene to be faster. Clindamycin/BPO seemed to act more quickly than adapalene. Inconsistent results were seen for the comparison of clindamycin/BPO and BPO alone with a slight indication of a shorter TOA for clindamycin/BPO. Adapalene/BPO and clindamycin/BPO showed comparable TOA. When interpreting the data, the different study designs and the limited study quality need to be taken into account. Further research is needed to identify treatments that offer an early onset of action and possibly help to optimize patients' adherence. TOA should be considered as an additional outcome in acne trials.

  15. Practical Evaluation and Management of Atrophic Acne Scars: Tips for the General Dermatologist

    OpenAIRE

    Fife, Douglas

    2011-01-01

    Atrophic acne scarring is an unfortunate, permanent complication of acne vulgaris, which may be associated with significant psychological distress. General dermatologists are frequently presented with the challenge of evaluating and providing treatment recommendations to patients with acne scars. This article reviews a practical, step-by-step approach to evaluating the patient with atrophic acne scars. An algorithm for providing treatment options is presented, along with pitfalls to avoid. A ...

  16. Adherence to acne treatment guidelines in the military environment - a descriptive, serial cross-sectional study

    OpenAIRE

    Fleischmann, Chen; Cohen, Lior; Adams, Elimelech; Hartal, Michael

    2015-01-01

    Background Acne vulgaris, a common skin disease, affects up to 80 % of the population. Moderate to severe acne requires treatment with a combination of topical and oral drugs such as antibiotics, hormones and retinoids. Retinoids have many contraindications and adverse effects requiring close monitoring. The study’s objectives were to describe prescribing trends in acne medication over time in a military setting, and assess physician adherence to guidelines for acne treatment, including drug ...

  17. Efficacy of an Unani Formulation in Reducing Post Inflammatory Acne Hyperpigmentation Marks- A Clinical Study

    OpenAIRE

    Shabiya Sultana; Shah nawaz; Abdul Haseeb Ansari; Mohd. Zulkifle

    2015-01-01

    There is no single malady which causes supplementary psychic disturbance and more general insecurity and feeling of inferiority than acne vulgaris with post inflammatory acne pigmentation marks does. It is strongly associated with depression and anxiety. In addition to individuals with little objective evidence acne with post inflammatory acne hyperpigmentation marks may endure severe subjective impairment, greatly affecting their health related quality of life. Unani System of Medicine conta...

  18. Deciphering the effect of novel bacterial exopolysaccharide-based nanoparticle cream against Propionibacterium acnes

    OpenAIRE

    Karlapudi, Abraham P.; Kodali, Vidya P.; Kota, Krishna P.; Shaik, Sabiha S.; Sampath Kumar, N. S.; Vijaya R. Dirisala

    2016-01-01

    Acne vulgaris (acne) is a chronic inflammatory disease prevalent among adolescents and adults, with significant psychological effects. The aetiology of acne is multifactorial. Several pathophysiological associations have been identified in which Propionibacterium acnes plays a major role. This bacteria primarily affects areas containing oil glands including the face, back and trunk, where it causes the formation of seborrhoea and inflammatory lesions. The treatment methods currently in place ...

  19. Sacroiliitis after use of oral isotretinoin - association with acne fulminans or adverse effect?*

    OpenAIRE

    Geller, Ariane Silva Bastos; Alagia, Roberta Ferreira Nazareth

    2013-01-01

    Acne fulminans is a rare and severe form of acne that may evolve from acne vulgaris, especially in male adolescents, or occur as an adverse effect of oral isotretinoin. Arthritis is a serious clinical manifestation when the musculoskeletal system is compromised by AF and has been reported as a rare adverse effect of isotretinoin. Involvement of the sacroiliac joints occurs in 21% of acne fulminans cases. We present the case of a 18-year-old male patient in whom acne fulminans evolved from acn...

  20. When do efficacy outcomes in clinical trials correlate with clinical relevance? analysis of clindamycin phosphate 1.2%-benzoyl peroxide 3.75% gel in moderate to severe acne vulgaris.

    Science.gov (United States)

    Del Rosso, James Q

    2016-07-01

    Acne vulgaris (AV) is a common skin disease that is challenging to successfully treat due to its complex underlying pathophysiology and chronicity. Unrealistic expectations based on the desire for rapid and complete clearance or local tolerability reactions related to topical medications often lead to incomplete adherence with therapy, premature treatment cessation, and poor therapeutic outcomes. Despite stressing to patients the importance of compliance and the lag time of several weeks before visible improvement may be noted with treatments for AV, data on evaluation of the time taken to achieve a clinically meaningful improvement of AV that may be perceived by clinicians and patients are limited. Clindamycin phosphate 1.2%-benzoyl peroxide 3.75% (clindamycin-BP 3.75%) gel has been shown in pivotal trials to be effective and well tolerated in patients with moderate to severe AV. This article reviews a new concept referred to as time to onset of action (TOA), which is described in detail and illustrated using the pivotal trial data with clindamycin-BP 3.75% gel for treatment of AV. PMID:27529706

  1. 夫西地酸乳膏联合阿达帕林凝胶治疗寻常痤疮的临床观察%Clinical Therapeutic Effect of Fusidic Acid Cream Combine Adapalene Gel for Acne Vulgaris

    Institute of Scientific and Technical Information of China (English)

    龙福泉; 王千秋

    2012-01-01

    Objective To evaluate the clinical efficacy and safety of 2% fusidic acid cream and 0. 1% adapalene gel in the treatment of mild and moderate acne vulgaris. Methods A total of 246 patients with mild to moderate ( Grade I - HI ) acne vulgaris were enrolled and randomly divided into 3 groups: 98 cases in treatment group which were treated by 2% fusidic acid cream combined with 0. 1% adapalene gel; 81 cases in control group A which were treated by 1% clindamyein phosphate gel combined with 0. 1% adapalene gel; 67 cases in control group B which were treated only by 0. 1% adapalene gel. All the patients recieved therapy for 8 weeks continuously and had been observed to evaluate the efficacy on the second, fourth and eighth week of treatment. Results On the eighth week of treatment, the total effective rate of treatment group was 93.88% , and there was a significant difference compared with the control group A( 81. 48% ,P =0.010) , meanwhile, the effective rate of treatment group in acne vulgaris with Grade HI was 93. 02% and there was also significant difference between these two groups( 69. 70% ,P =0. 007 ). After the treatment, there were 5 cases of recurrence in the treatment group and the recurrence rate was 5. 10% , however, it was much lower than that of two control groups. The group treated only by 0.1 % adapalene gel had poor effect and higher recurrence. All these 3 groups had not obvious side-effect during Ireatment. Conclusion It is an ideal therapy by using 2% fusidie acid cream combined with 0.1 % adapalene gel in the treatment of mild to moderate acne vulgaris with belter effect, lower recurrence rate and less side-effect.A 41-year old male with aplastic anemia history of 1 year, suffered pedicled wart on the praeputium for more than 4 months. Laboratory examination: platelet account 28 ×109/L, haematoglobin 90g/L. Diagnosis; con-dyloma acuminatum, aplastic anemia. Therapy; We applied ligature to the patient. The wart body was removed completely after 21

  2. The Association between Cigarette Smoking and Acne Intensity

    Directory of Open Access Journals (Sweden)

    Taheri Ramin

    2009-06-01

    Full Text Available Background: Acne vulgaris is a common chronic inflammatory disease of pilosebaceous unit. Different factors have been suggested to influence acne including diet, menstruation and occupation. The role of some of these factors on acne intensity is confirmed. The affect of Cigarette smoking on acne intensity has been suggested. In this research, we evaluated the association between cigarette smoking and the acne intensity.Materials and Methods: This cross-sectional study was performed on 278 smoker and 277non smoker males referred to dermatology clinics of Semnan during 2006-2007. The dermatologists interviewing the patients completed questionnaires based on clinical diagnosis and intensity of acne. Data analysis was performed using t-test, Mann-Whitney, Chi-square and Spearman coefficient tests. P-value less than 0.05 were considered significant. Results: Severe acne was observed in 16.6% of non-smokers and 22.7% of smokers. Distribution of acne intensity in both groups was significant (P=0.023. Association between duration of cigarette smoking and acne intensity was significant too (P<0.001. The association between dosage of cigarette smoking and acne intensity was also significant (P<0.001.Conclusion: Significant association between cigarette smoking and acne intensity showed that smoking withdrawal is helpful for reducing the acne intensity

  3. Analysis on the Patterns and Formulas in Treatment of Acne Vulgaris Based on Literature Research%基于文献研究的寻常痤疮证型与方药分析

    Institute of Scientific and Technical Information of China (English)

    金浩然; 康润芳; 杨恩品

    2015-01-01

    Objective To explore the characteristics of TCM pattern distribution and rule of herbal prescription in treatment of acne vulgaris. Methods The secondary literature research method was used. The relevant literatures were retrieved on the treatment of acne in recent 20 years. Based on the inclusive and ex-clusive criteria,30 target literatures were enrolled. The descriptive statistical method was adopted for analysis and collection. Results The pattern sequence,from high frequency to low one,is spleen and stomach damp heat,wind heat in lung meridian,stagnation of phlegm,damp and stasis,interaction of phlegm and stasis,heat accumulation in lung and stomach,etc. The most common formulas are pipa qingfei yin,yinchenhao tang,tao-hong siwu tang,wuwei xiaodu yin,haizao yuhu tang,senling baizhu san,etc. The herbs with the use frequency up to 30 times are radix scutellariae,radix glycyrrhizae,radix paeoniae rubra,cortex moutan,gardenia,radix rehmanniae,cortex mori and angelica sinensis. Conclusion Most cases of acne vulgaris are excess syndrome and mixed syndrome. The common prescriptions are mainly for clearing heat,detoxification,cooling blood and removing dampness.%目的:探讨寻常痤疮的中医证型分布特点及处方用药规律。方法按照二次文献研究方法,检索近20年治疗痤疮的相关文献,通过纳入排除标准,选择到目标文献30篇,再用描述性统计学方法进行分析整理。结果出现频率最高的证型依次为脾胃湿热、肺经风热、痰湿瘀滞、痰瘀互结、肺胃积热等;最常使用的方剂为枇杷清肺饮、茵陈蒿汤、桃红四物汤、五味消毒饮、海藻玉壶汤合参苓白术散等;使用频次在30次以上的药物依次为黄芩、甘草、赤芍、丹皮、栀子、生地、桑白皮、当归。结论寻常痤疮的证型以实证为主且复合证型居多;处方用药常选用清热解毒、凉血除湿类方药。

  4. Acne Surgery

    OpenAIRE

    Dilworth, G. R.

    1983-01-01

    Acne surgery consists of comedone extraction of non-inflamed lesions, triamcinolone acetate injections of some inflamed lesions, and extraction of milia. Prevention is a very important part of comedone treatment, especially avoidance of picking, moisturizers and harsh soaps. Instruments are also very important: even the finest may be too thick and may have to be filed down. Acne surgery is only an adjunct of good medical therapy.

  5. Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment.

    Directory of Open Access Journals (Sweden)

    Teruaki Nakatsuji

    Full Text Available BACKGROUND: In the progression of acne vulgaris, the disruption of follicular epithelia by an over-growth of Propionibacterium acnes (P. acnes permits the bacteria to spread and become in contact with various skin and immune cells. METHODOLOGY/PRINCIPAL FINDINGS: We have demonstrated in the present study that the Christie, Atkins, Munch-Peterson (CAMP factor of P. acnes is a secretory protein with co-hemolytic activity with sphingomyelinase that can confer cytotoxicity to HaCaT keratinocytes and RAW264.7 macrophages. The CAMP factor from bacteria and acid sphingomyelinase (ASMase from the host cells were simultaneously present in the culture supernatant only when the cells were co-cultured with P. acnes. Either anti-CAMP factor serum or desipramine, a selective ASMase inhibitor, significantly abrogated the P. acnes-induced cell death of HaCaT and RAW264.7 cells. Intradermal injection of ICR mouse ears with live P. acnes induced considerable ear inflammation, macrophage infiltration, and an increase in cellular soluble ASMase. Suppression of ASMase by systemic treatment with desipramine significantly reduced inflammatory reaction induced by intradermal injection with P. acnes, suggesting the contribution of host ASMase in P. acnes-induced inflammatory reaction in vivo. Vaccination of mice with CAMP factor elicited a protective immunity against P. acnes-induced ear inflammation, indicating the involvement of CAMP factor in P. acnes-induced inflammation. Most notably, suppression of both bacterial CAMP factor and host ASMase using vaccination and specific antibody injection, respectively, cooperatively alleviated P. acnes-induced inflammation. CONCLUSIONS/SIGNIFICANCE: These findings envision a novel infectious mechanism by which P. acnes CAMP factor may hijack host ASMase to amplify bacterial virulence to degrade and invade host cells. This work has identified both CAMP factor and ASMase as potential molecular targets for the development of drugs

  6. A brief primer on acne therapy for adolescents with skin of color.

    Science.gov (United States)

    Silverberg, Nanette B

    2013-07-01

    The majority of adolescents with skin of color in the United States and other westernized civilizations develop acne vulgaris. Indigenous populations of children and teenagers with skin of color may not develop acne when raised on a paleolithic diet, suggesting the Western diet is the rudiment of acne vulgaris. Differences exist in the presentation of and therapy for acne in teenagers with skin of color, largely due to the increased risk for hyperpigmentation, scarring, and keloid formation, as well as style- and skin care-related exacerbating factors. The primary goal of acne therapy in adolescents with skin of color is the prevention of long-term sequelae such as keloid formation. This article provides a brief overview of the treatment of acne vulgaris in adolescents with skin of color. PMID:23961520

  7. Draft Genome Sequences of Two Propionibacterium acnes Strains Isolated from Progressive Macular Hypomelanosis Lesions of Human Skin

    DEFF Research Database (Denmark)

    Petersen, Rolf; Lomholt, Hans B.; Scholz, Christian F. P.;

    2015-01-01

    Propionibacterium acnes is a Gram-positive bacterium that is prevalent on human skin. It has been associated with skin disorders such as acne vulgaris and progressive macular hypomelanosis (PMH). Here, we report draft genome sequences of two type III P. acnes strains, PMH5 and PMH7, isolated from...

  8. Should dermatologists prescribe hormonal contraceptives for acne?

    Science.gov (United States)

    Harper, Julie C

    2009-01-01

    ABSTRACT One of the primary factors contributing to the development of acne vulgaris is excess sebum. Sebaceous glands and sebum excretion are regulated, at least in part, by androgen hormones. Acne treatments that block this androgen effect include spironolactone and combination oral contraceptives (COC). Three COC are now FDA approved to treat moderate acne. Dermatologists must become experts at prescribing these hormonal contraceptives. Likewise, it is vital to be aware of contraindications to hormonal contraceptive therapy. Proper patient selection relies on an appropriate medical history and an assessment of blood pressure. A pelvic exam and/or Papanicolaou smear are not required prior to initiating therapy with a COC. It is important to counsel patients about potential adverse effects of COC pills and to establish appropriate expectations concerning acne improvement. PMID:19845722

  9. The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells.

    Science.gov (United States)

    Michalak-Stoma, Anna; Tabarkiewicz, Jacek; Olender, Alina; Juszkiewicz-Borowiec, Maria; Stoma, Filip; Pietrzak, Aldona; Pozarowski, Piotr; Bartkowiak-Emeryk, Małgorzata

    2008-01-01

    Propionibacterium acnes (P. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder. It has a proinflammatory activity and takes part in immune reactions modulating the Th1/Th2 cellular response. The exposure of dendritic cells (DCs) to whole bacteria, their components, cytokines or other inflammatory stimuli and infectious agents induces differentiation from immature DCs into antigen-presenting mature DCs. The aim of the study was to evaluate the capability of P. acnes to induce the maturation of DCs. We stimulated monocyte derived dendritic cells (Mo-DCs) from acne patients with various concetrations of heat-killed P. acnes (10(6)-10(8) bacteria/ml) cultured from acne lesions. The results showed an increase in CD80+/CD86+/DR+ and CD83+/CD1a+/DR+ cells percentage depending on the concetration of P. acnes. The expression of CD83 and CD80 (shown as the mean fluorescence intensity - MFI) increased with higher concetrations of P. acnes. There were also significant correlations between MFI of CD83, CD80, CD86 and concetration of P. acnes. The study showed that P. acnes in the concetration of 10(8) bacteria/ml is most effective in the induction of Mo-DCs maturation. Futher studies concerning the influence on the function of T cells are needed.

  10. The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells.

    Directory of Open Access Journals (Sweden)

    Maria Juszkiewicz-Borowiec

    2009-01-01

    Full Text Available Propionibacterium acnes (P. acnes has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder. It has a proinflammatory activity and takes part in immune reactions modulating the Th1/Th2 cellular response. The exposure of dendritic cells (DCs to whole bacteria, their components, cytokines or other inflammatory stimuli and infectious agents induces differentiation from immature DCs into antigen-presenting mature DCs. The aim of the study was to evaluate the capability of P. acnes to induce the maturation of DCs. We stimulated monocyte derived dendritic cells (Mo-DCs from acne patients with various concetrations of heat-killed P. acnes (10(6-10(8 bacteria/ml cultured from acne lesions. The results showed an increase in CD80+/CD86+/DR+ and CD83+/CD1a+/DR+ cells percentage depending on the concetration of P. acnes. The expression of CD83 and CD80 (shown as the mean fluorescence intensity - MFI increased with higher concetrations of P. acnes. There were also significant correlations between MFI of CD83, CD80, CD86 and concetration of P. acnes. The study showed that P. acnes in the concetration of 10(8 bacteria/ml is most effective in the induction of Mo-DCs maturation. Futher studies concerning the influence on the function of T cells are needed.

  11. Formulation and evaluation of herbal anti-acne moisturizer.

    Science.gov (United States)

    Rasheed, Arun; Shama, Shaik Neelufar; Joy, Jyothi Mulanjananiyil; Reddy, Bobbu Sravya; Roja, Chirra

    2012-10-01

    The moisture content present in human skin makes it look young and the use of moisturizer results in fastening the moisture with a surface film of oil. Acne vulgaris is one of the most commonly seen diseases among the youth. The present study is focused on the use of herbs as moisturizer for acne treatment. The anti-acne moisturizer was formulated from herbal crude extracts and investigated the physico-chemical parameters as well as antibacterial activity of the formulation. The study revealed that ethanol extract of Andrographis paniculata, Glycyrrhiza glabra, Ocimum sanctum, Azadiracta indica and Green tea possessed the potential for inhibiting acne. It was observed that the optimal formula of anti-acne moisturizer was satisfactorily effective to control acne inducing bacteria i.e., Staphylococcus epidermis and Propionibacterium. The physico-chemical parameters of the formulation were also optimal with no signs of irritation. PMID:23010007

  12. Hubungan Konsumsi Makanan Cepat Saji Terhadap Kejadian Akne Vulgaris pada Mahasiswa FK USU Stambuk 2007

    OpenAIRE

    Bancin, Berry Eka Parda

    2011-01-01

    Introduction. Acne vulgaris is a very common disease found in public, especially in adolescence. About 85% of people in their life have had acne vulgaris, so it’s often assumed as a physiological state. High-calorie foods have been long suspected as one of the causes of this disease, this opinion is supported by the increased incidence of acne vulgaris in developing countries today. Since 1946 to 2007 various studies have been conducted on the relationship of food to the occurrence of acne vu...

  13. Can I Prevent Acne?

    Science.gov (United States)

    ... Help a Friend Who Cuts? Can I Prevent Acne? KidsHealth > For Teens > Can I Prevent Acne? Print ... en español ¿Puedo prevenir el acné? What Causes Acne? Contrary to what you may have heard, acne ...

  14. 中药面膜综合疗法治疗寻常痤疮的临床研究%Effects of Chinese Medical Facial Mask Comprehensive Therapy in Treating Acne Vulgaris

    Institute of Scientific and Technical Information of China (English)

    曾雪; 张晓红; 沈冬; 丁旭; 华华; 闫雨荷; 王煜明; 乔丽; 陈弘平; 刘瓦利; 赵婷; 赵俊英; 瞿幸; 徐志莉; 田野; 崔炳南; 吴小红

    2012-01-01

    目的 评价中药面膜综合疗法对Ⅰ~Ⅲ度寻常痤疮的临床疗效及安全性.方法 将233例(FAS集)Ⅰ~Ⅲ度寻常痤疮患者随机分为面膜组(113例)和西药组(120例),分别采用中药面膜综合疗法和5%过氧化苯甲酰凝胶外用治疗,面膜组每周治疗2次,西药组每晚治疗1次,均连续治疗4周.分别于治疗1、2、4周后观察皮损积分及中医证候积分改善情况,记录不良反应发生率以及受试者对中药面膜综合疗法使用后的评价.结果 233例病例共完成228例(超窗7例,PPS集221例,其中面膜组105例,西药组116例).治疗4周后,面膜组皮损及中医证候疗效总有效率明显高于对照组(46.9%vs 30.0%,70.8%vs55.8%,P<0.05),FAS集与PPS集统计结果一致.治疗4周后,面膜组PPS集皮损积分及中医证候积分低于西药组,差异均有统计学意义(P≤0.05).治疗2、4周后,两组FAS集与PPS集皮损积分治疗前后差值及中医证候积分治疗前后差值比较,面膜组均明显大于西药组(P<0.05).面膜组和西药组不良反应发生率分别为1.8% (2/113)、2.5% (3/120),两组比较差异无统计学意义(P>0.05).结论 中药面膜综合疗法治疗Ⅰ~Ⅲ度寻常痤疮安全有效,不良反应发生率低,易于操作及推广.%Objective To evaluate the clinical effectiveness and safety of Chinese medical facial mask comprehensive therapy in treating acne vulgaris. Methods Totally 233 acne vulgaris patients (FAS set) in I -ID degree were randomly assigned to the facial mask group (113 cases) and the Western medicine group (120 cases). They were respectively treated with external application of Chinese medical facial mask (twice a week) and 5% benzoly peroxide gel (Benzihex, once in the evening). The treatment lasted for four successive weeks. The integrals of lesions and the improvement of Chinese medicine syndrome integrals were observed 1 week, 2 weeks and 4 weeks after treatment respectively. The

  15. 光动力疗法治疗寻常痤疮疗效和安全性的系统评价%Efficacy and Safety of Photodynamic Therapy for Acne Vulgaris: A Systematic Review

    Institute of Scientific and Technical Information of China (English)

    陆梦婷; 王恒; 吴剑波

    2015-01-01

    目的 系统评价光动力疗法(photodynamic therapy,PDT)治疗寻常痤疮的临床疗效及安全性.方法 计算机检索PubMed、The Cochrane Library、EMbase、CNKI、VIP和WanFang Data数据库,搜集PDT治疗寻常痤疮的随机对照试验(randomized control trials,RCTs),检索时间均为从建库至2013年8月9日.同时,追溯纳入研究的参考文献,以补充获取相关文献.由2位评价员按纳入与排除标准独立筛选文献、提取资料并评价质量后,采用RevMan 5.2软件进行Meta分析.结果 共纳入8个RCT,271例患者.因纳入研究的干预措施不同,我们仅对干预措施相同的RCT进行了合并分析,结果显示5-氨基酮戊酸(5-Aminolevulinicacid,ALA)-红光-PDT疗效优于单纯红光[RR=1.78,95%CI(1.30,2.43),P<0.0S].而对其余研究的描述性分析结果显示:ALA-强脉冲光(intense pulse light,IPL)-PDT疗效优于单纯IPL,氨基乙酰丙酸甲酯(methyl-5 aminolevulinate,MAL)-红光-PDT疗效优于单纯红光,MAL-红光-PDT疗效与MAL-IPL-PDT疗效相当.结论 PDT治疗寻常痤疮可能有效,但存在灼热、疼痛、红斑、水肿、色素沉着、痤疮样发疹等不良反应,患者一般可耐受.受纳入研究数量和质量所限,本研究结论尚需开展更多高质量研究进行验证.%Objective To systematically evaluate the efficacy and safety of photodynamic therapy (PDT) for acne vulgaris.Methods PubMed,EMbase,The Cochrane Library,CNKI,WanFang Data and VIP databases were electronically searched from inception to August 9th,2013,to collect randomized controlled trials (RCTs) about PDT for acne vulgaris.References of included studies were also retrieved.Two reviewers independently screened literature according to the inclusion and exclusion criteria,extracted data and assessed the risk of bias of included studies.Then,meta-analysis was performed using RevMan 5.2 software.Results A total of 8 RCTs involving 271 patients were included.Because the interventions of included

  16. Acne Scars

    Science.gov (United States)

    ... for treating acne scars include: Improved appearance Enhanced self-esteem Promotion of better skin health What you need ... 480px View Render 320px View Connect with ASDS: Facebook LinkedIn YouTube Twitter Quick Links About ASDS Advocacy ...

  17. Draft Genome Sequence of an Antibiotic-Resistant Propionibacterium acnes Strain, PRP-38, from the Novel Type IC Cluster

    OpenAIRE

    McDowell, Andrew; Hunyadkürti, Judit; Horváth, Balázs; Vörös, Andrea; Barnard, Emma; Patrick, Sheila; Nagy, István

    2012-01-01

    Propionibacterium acnes, a non-spore-forming, anaerobic Gram-positive bacterium, is most notably recognized for its association with acne vulgaris (I. Kurokawa et al., Exp. Dermatol. 18:821–832, 2009). We now present the draft genome sequence of an antibiotic-resistant P. acnes strain, PRP-38, isolated from an acne patient in the United Kingdom and belonging to the novel type IC cluster.

  18. Can Acne Scars Be Removed?

    Science.gov (United States)

    ... Can I Help a Friend Who Cuts? Can Acne Scars Be Removed? KidsHealth > For Teens > Can Acne ... eliminarse las marcas de acne? Different Types of Acne Scars from acne can seem like double punishment — ...

  19. Isotretinoin for acne and rosacea.

    Science.gov (United States)

    Watson, Kendra D; Miest, Rachel Y; Tollefson, Megha M

    2016-06-01

    Isotretinoin is a revolutionary medicine for the treatment of acne vulgaris, with new studies showing evidence of excellent clinical outcomes in treating rosacea. After 30 years of clinical experience, new insights are being gained into dosing strategies, recurrence prevention, and dose-related side effects. Previous controversial associations with inflammatory bowel diseases and mood disorders have hampered the use of this medication in some clinical situations, with new evidence disproving these claims. The teratogenicity of this medication mandates iPLEDGE compliance with government regulations. Clinicians should be knowledgeable about this medication including its side effects, teratogenicity, and its controversies in order to adequately counsel patients, dissuade fears, and obtain the best clinical outcome when treating acne and rosacea. PMID:27416313

  20. Acne Facts and Stats

    Science.gov (United States)

    ... Conditions Cosmetic treatments Prevention and care News releases Acne Acne is the most common skin condition in the ... affecting up to 50 million Americans annually. 1 Acne often causes significant physical and psychological problems such ...

  1. Acne Keloidalis Nuchae

    Science.gov (United States)

    ... rash and rashes clinical tools newsletter | contact Share | Acne Keloidalis Nuchae Information for adults A A A ... neck at the hairline that is affected by acne keloidalis nuchae. Overview Acne keloidalis nuchae, also known ...

  2. Nanoparticle Stabilized Liposomes for Acne Therapy

    Science.gov (United States)

    Fu, Victoria

    Acne vulgaris is a common skin disease that affects over 40 million people in the United States alone. The main cause of acne vulgaris is Propionibacterium acnes (P. acnes), resides deep in the pores and follicles of the skin in order to feed on oil produced by the sebaceous glands. The liposome is a lipid based nanoparticle with numerous advantages over free drug molecules as an acne treatment alternative. Bare liposomes loaded with lauric acid (LipoLA) were found to show strong antimicrobial activity against P. acnes while generating minimal toxicity. However, the platform is limited by the spontaneous tendency of liposomes to fuse with each other. Attaching nanoparticles to the surface of liposomes can overcome this challenge by providing steric repulsion and reduce surface tension. Thus, carboxyl-functionalized gold nanoparticles (AuC) were attached to the surface of liposomes (AuC-liposomes) loaded with doxycycline, a general tetracycline antibiotic. These particles were found to have a diameter of 120 nm and a zeta potential of 20.0 mV. Both fluorescent and antimicrobial studies demonstrated that based on electrostatic interaction, negatively charged AuC attached to the liposome's positively charged surface and stabilized liposomes in a neutral pH environment (pH = 7.4). Upon entering the skin's acidic environment (pH = 4), AuC detached from the liposome's surface and liposomes could fuse with P. acnes residing in the pores. Furthermore, toxicity studies showed that AuC-liposomes did not induce any significant toxicity, while two of the leading over-the-counter therapies, benzoyl peroxide and salicylic acid, generated substantial skin irritation.

  3. A Family Physician's Approach to the Treatment of Acne

    OpenAIRE

    Rockerbie, Neil R.

    1988-01-01

    Acne vulgaris is a condition seen commonly in family practice. It is well recognized by physicians but, in general, poorly treated. An understanding of the disease process and of the medications used is essential to proper treatment. Moreover each case must be treated individually with a specific treatment regimen, depending on the type and severity of acne. The author of this paper deals with the disease process and medications, and suggests a treatment strategy useful for the primary care p...

  4. Profiling and Hormonal Therapy for Acne in Women

    OpenAIRE

    Sangita Ghosh; Soumik Chaudhuri; Vijay Kumar Jain; Kamal Aggarwal

    2014-01-01

    Acne vulgaris is the most common condition treated by physicians worldwide. Though most acne patients remit spontaneously, for the ones that do not or are unresponsive to conventional therapy or have obvious cutaneous signs of hyperandrogenism, hormonal therapy is the next option in the therapeutic ladder. It is not strictly indicated for only those patients who have cutaneous or biochemical evidence of hyperandrogenism, but can be used even without any evidence of hyperandrogenism, for thera...

  5. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

    OpenAIRE

    Melnik BC

    2015-01-01

    Bodo C Melnik Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Germany Abstract: Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet. Three major food classes that promote acne are: 1) hyperglycemic carbohydrates, 2) milk and dairy products, 3) saturated fats including trans-fats and deficient ω-3 polyunsaturated fatty acids (PUFAs). Diet-induced insulin/insulin-like growth fac...

  6. Observation of Chinese medicine gesso pour film and red, blue light phototherapy in treatment of acne vulgaris%中药石膏倒膜联合红蓝光交替照射治疗寻常痤疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    张丽君

    2014-01-01

    Object To observe the clinical effect and security of Chinese medicine gesso pour film and red, blue light phototherapy in treatment of acne vulgaris. Methods: 110 cases of acne were divided into treatment group and control group with 55 cases. Treatment group were treated by Chinese medicine gesso pour film combined with red, blue light phototherapy. Control group were treated with red, blue light phototherapy. Results: The total effective rate of treatment group was higher than control group, the difference was statistically significant (p<0.05). Conclusions: The therapy of Chinese medicine gesso pour film combined with red, blue light phototherapy has a good effect in treating vulgaris acne, worth clinical promotion.%目的:评价中药石膏倒膜联合红蓝光交替照射治疗寻常痤疮的疗效及安全性。方法将110例寻常型痤疮患者,随机分为治疗组和对照组,各55例。治疗组采用中药石膏倒膜联合红蓝光交替照射治疗,对照组仅采用红蓝光照射治疗。结果治疗组有效率高于对照组,两组相比差异显著(p<0.05)。结论中药石膏倒膜联合红蓝光交替照射治疗寻常痤疮,疗效满意,值得临床推广。

  7. Adolescent female acne: etiology and management.

    Science.gov (United States)

    Olutunmbi, Yetunde; Paley, Kristina; English, Joseph C

    2008-08-01

    Acne vulgaris, a multifactorial condition often conferring significant psychosocial morbidity, affects an estimated 40 million people in the United States. The majority of these individuals are adolescents and young adults. The pathophysiology of the condition is still not fully known, but it is believed to be related in part to excess sebum production, follicular hyperkeratinization, microbial colonization by P acnes, and inflammation. Prior to initiating treatment in a female patient, a hyperandrogenic state must be considered and ruled out through history, physical exam, and laboratory evaluation if necessary. Treatment options are vast and include hormonal therapy among others. Hormonal therapies have long been noted to reduce acne lesions and offer a valuable adjuvant to standard therapy. Hormonal agents are thought to improve acne by blocking the androgen receptor and/or decreasing circulating androgens which leads to decreased sebum production. Hormonal treatment options include spironolactone, other antiandrogens, and oral contraceptives. The use of these agents to effectively treat acne has been demonstrated in several randomized, placebo-controlled clinical trials. Optimal results are often achieved with combination therapy with the goal of targeting multiple pathogenic pathways in acne development. PMID:18656070

  8. Cultural adaptation of the Cardiff Acne Disability Index to a hindi speaking population: A pilot study

    OpenAIRE

    Aayush Gupta; Yugal K Sharma; K Dash; Sampurna Verma

    2015-01-01

    Background: Acne vulgaris is known to impair many aspects of the quality of life (QoL) of its patients. Aim: To translate the Cardiff Acne Disability Index (CADI) from English into Hindi and to assess its validity and reliability in Hindi speaking patients with acne from India. Methods: Hindi version of CADI, translated and linguistically validated as per published international guidelines, along with a previously translated Hindi version of dermatology life quality index (DLQI) and a demogra...

  9. Complete Genome Sequences of Three Propionibacterium acnes Isolates from the Type IA2 Cluster

    OpenAIRE

    Vörös, Andrea; Horváth, Balázs; Hunyadkürti, Judit; McDowell, Andrew; Barnard, Emma; Patrick, Sheila; Nagy, István

    2012-01-01

    Propionibacterium acnes is an anaerobic Gram-positive bacterium that has been linked to a wide range of opportunistic human infections and conditions, most notably acne vulgaris (I. Kurokawa et al., Exp. Dermatol. 18:821–832, 2009). We now present the whole-genome sequences of three P. acnes strains from the type IA2 cluster which were recovered from ophthalmic infections (A. McDowell et al., Microbiology 157:1990–2003, 2011).

  10. 云南汉族痤疮与CYP11B1基因多态性的相关性研究%Association of CYP11B1 gene polymorphisms with acne vulgaris in Han populations in Yunnan province

    Institute of Scientific and Technical Information of China (English)

    杨婷; 何黎; 李玉明; 吴文娟; 涂颖; 杨智; 杨小燕; 起珏

    2013-01-01

    目的 探讨CYP11B1基因多态性与痤疮发病风险之间的相关性.方法 SNaPshot法对云南汉族403例痤疮患者(包括轻型痤疮166例、重型痤疮237例)和207例健康对照CYP11B1基因2个单核苷酸多态性位点:rs4736312和rs4534位点进行分型,ABI 3730XL扫描分型结果.结果 rs4736312位点:男性轻型痤疮组AA、AC和CC基因型频率分别为0、20.6%、79.4%,重型痤疮组为1.8%、26.8%、71.4%,男性健康对照组为7.6%、34.8%、57.6%.A等位基因的频率分布在男性痤疮组与健康对照组间、男性轻型痤疮与健康对照组间以及男性重型痤疮与健康对照组间,差异均具有统计学意义(分别为P< 0.01、<0.05、<0.05),而女性痤疮组、女性轻型痤疮组、女性重型痤疮组A、G等位基因频率分布与健康对照组相比,差异均无统计学意义(P>0.05).rs4534位点:男性、女性两组别的痤疮组、轻型痤疮组及重型痤疮组的AA、AG、GG基因型频率分布和A、G等位基因频率分布与各自健康对照组间,差异均无统计学意义(P>0.05).结论 CYP11B1基因中rs4736312位点与云南汉族男性痤疮发病相关,而rs4534位点与云南汉族痤疮的发病无相关.%Objective To analyze the association of CYP11B 1 gene polymorphisms with the risk of acne vulgaris in Han populations in Yunnan province.Methods Totally,403 patients with acne (including 166 cases of mild acne and 237 cases of severe acne) and 207 healthy controls of Han nationality in Yunnan province were recruited to this study.Genomic DNA was extracted from the peripheral blood samples of these subjects.A SNaPshot assay was performed to determine the genotypes of two single nucleotide polymorphisms (SNPs) of the CYP11B1 gene,including rs4736312 and rs4534.The extension products were analyzed by eleetrophoresis in an ABI Prism 3730xl DNA analyzer.Results The frequency of AA,AC and CC genotype of the SNP rs4736312 was 7.6%,34.8% and 57.6

  11. Efficacy and safety of multiple vitamin E, C, B facial mask for 117 patients with acne vulgaris%复合维生素E,C,B组合物面膜治疗寻常痤疮117例的疗效和安全性

    Institute of Scientific and Technical Information of China (English)

    赵昭明; 陈荣福

    2005-01-01

    目的:了解维生素E,C,B组合物面膜治疗寻常痤疮的疗效及安全性.方法:117例13 a以上、痤疮严重程度分级在2级以上且主要表现于脸部的病人,予维生素E,C,B组合物面膜治疗,每日1次,共8 wk.观察治疗前后痤疮数量及性质,包括粉刺、丘疹、脓疱及囊肿之数目,并评估整体疗效.结果:治疗后,粉刺、丘疹、脓疱及囊肿数目下降了13±s 13,10±12,5±7及3±3,均P<0.01.7例(6.0%)病人症状完全改善,44例(37.6%)中度改善,56例(47.9%)轻度改善,10例(8.6%)无改善.59例(50.4%)病人无红肿、搔痒、灼热及脱皮等现象发生.结论:维生素E,C,B组合物面膜治疗痤疮有效,超过半数的受试者无不良反应发生,可作为传统治疗寻常痤疮药物的替代.%AIM: To evaluate the efficacy and safety of multiple vitamin E, C, B facial mask for the patients with acne vulgaris. METHODS: One hundred and seventeen patients aged over 13 a, with acnes mainly sited on the face and an acne severity rating above grade 2 were enrolled in this study. The mask treatment was used once a day with 8 wk as a course.The primary endpoint included the number and the degree of acne lesions including comedoes, papules, pustules and cysts. The secondary endpoint was the overall efficacy evaluation by the physicians. RESULTS:After 8 wk of treatment with multiple vitamin E, C, B facial mask, the mean number of acne lesions:comedoes, papules, pustules and cysts decreased 13 + s 13,10 ± 12, 5 + 7 and 3 + 3, respectively. These changes were statistically significant (P < 0.01 ). The results of overall efficacy evaluation showed that 7 patients '(6.0 % ) symptom was greatly improved, 44 patients '(37.6 % ) symptoms were moderately improved, 56patients'(47.9 % ) symptoms were slightly improved,and 10 patients' symptoms did not change. Among all 117 patients, 59 patients (50.4 % ) showed no adverse reactions, including swelling, redness, itching,burning or scaling. CONCLUSION

  12. Clinical comparative observation on red - blue light in combination with isotretinoin in the treatment of moderate to severe acne vulgaris%红蓝光联合异维 A 酸治疗中重度痤疮30例临床观察

    Institute of Scientific and Technical Information of China (English)

    王静

    2016-01-01

    Objective:To evaluate the therapeutic effect and safety of red - blue light in combination with isotretinoin in the treatment of moderate to severe acne vulgaris. Methods:All 60 cases with moderate to severe acne vulgaris were divided into two groups randomly,treatment group(30 cases)with red - blue light combination with isotretinoin treatment,the control group (30 cases)alone isotretinoin treatment. Resulus:The effective rate in two groups was compared. Results:The effective rate of the treatment group was 8 6 . 7 % ,that of the control group was 7 0 . 0 % ,and there were significant differences between them (P ﹤ 0. 05). Severe adverse effect which might cause termination of the treatment was not seen in two group. Conclusion:Red- blue light in combination with isotretinoin in the treatment of moderate to severe acne vulgaris has a significant clinical effect and high safety.%目的:探讨红蓝光照射联合异维 A 酸治疗中、重度痤疮的临床疗效和安全性。方法:将入选的60例中、重度痤疮患者随机分为两组,治疗组(30例)予红蓝光联合口服异维 A 酸治疗,对照组(30例)仅口服异维 A 酸治疗,比较两组的治疗效果。结果:有效率治疗组为86.7%,对照组为70.0%,差异有统计学意义(P ﹤0.05)。两组均未出现导致治疗终止的严重不良反应。结论:红蓝光联合异维 A 酸治疗中、重度痤疮疗效好,安全性高。

  13. 姜黄消痤搽剂联合红蓝光治疗寻常痤疮疗效观察%Observation of Clinical Effect of Compound Jiang Huang Xiao Cuo Liniment Combined Red-Blue Light in the Treatment of Acne Vulgaris

    Institute of Scientific and Technical Information of China (English)

    袁伟; 贾常莎

    2012-01-01

    Objective To evaluate the clinical effect of compound Jiang Huang Xiao Cuo Liniment combined red-blue light in the treatment of acne vulgaris. Methods One hundred and seventy-five cases of acne vulgaris were recruited and assigned into two groups randomly.The patients in treating group were treated with Jiang Huang Xiao Cuo Liniment combined with red-blue light,while the control group was treated with red-blue light only. After 4 weeks treatment, the effect was evaluated. Results The therapeutic effect in the treatment group was 82.22% and that in control group was 43.53%. The therapeutic effect of treatment group was significantly higher than those in control group(P < 0.01 ), while the clinical effects of second-degree and third-degree were higher than those of first-degree and fourth-degree in treatment group(P < 0.01). Conclusion Combined therapy of Jiang Huang Xiao Cuo Liniment and red-blue light is optimal choice for the treatment of acne vulgaris, which were effective and safe.%目的 探讨姜黄消痤搽剂与红蓝光联合应用治疗寻常痤疮的临床疗效.方法 将入选的175例寻常痤疮患者随机分为两组,治疗组采用姜黄消痤搽剂联合红蓝光照射治疗,对照组仅用红蓝光照射治疗,连续治疗4周后,按痤疮临床评分标准评价及记录疗效评分判断疗效.结果 治疗组的临床疗效明显高于对照组,其有效率为82.22%,对照组的有效率为43.53%,差异有统计学意义(P<0.01);治疗组中Ⅱ、Ⅲ度的疗效优于Ⅰ、Ⅳ度(P<0.01).结论 姜黄消痤搽剂与红蓝光联合治疗寻常痤疮起效快、疗效高、安全性好.

  14. Combined oral contraceptives for the treatment of acne: a practical guide.

    Science.gov (United States)

    Arrington, Elizabeth A; Patel, Nishit S; Gerancher, Karen; Feldman, Steven R

    2012-08-01

    Many therapies exist in the arsenal of drugs available to dermatologists for the treatment of acne vulgaris. Among them, hormonal therapy stands out as a unique and highly efficacious treatment modality. Although some dermatologists may be hesitant to prescribe hormonal therapies, they can be safely and appropriately used in eligible female patients to treat acne vulgaris. Herein, current issues regarding the hormonal treatment of acne in the form of combined oral contraceptives (COCs) are presented, and a practical method for implementing this therapy is proposed. Specifically, drug selection, associated risks, benefits, monitoring, and counseling are discussed, with emphasis on the practicality of use in the clinical setting. PMID:22988652

  15. Treatment considerations for inflammatory acne: clinical evidence for adapalene 0.1% in combination therapies.

    Science.gov (United States)

    Thiboutot, Diane M; Gollnick, Harald P

    2006-09-01

    Acne vulgaris is an exceptionally common, chronic, and recurring disease. It involves multiple etiological factors including follicular hyperkeratinization, increased sebum production, Propionibacterium acnes proliferation, and inflammation. Presently, oral isotretinoin is the only single agent that is effective against all 4 major pathophysiologic features. However, this drug is also responsible for several serious side effects, including teratogenicity. Therefore, it should be used in only the most severe cases and alternative treatment approaches for inflammatory acne, such as initial combination therapy, should be considered first. Combination therapy in inflammatory acne simultaneously targets multiple pathogenic factors. Current guidelines recommend early initiation of combination therapy with a topical retinoid and antimicrobials for mild to moderate inflammatory acne and topical retinoids with oral antibiotics (with or without the use of benzoyl peroxide) for moderate to severe cases of acne, followed by maintenance therapy with topical retinoids. This review evaluates the rationale and clinical evidence for the use of adapalene in combination therapy for inflammatory acne. PMID:16989194

  16. Laser and light based treatments of acne

    Directory of Open Access Journals (Sweden)

    Reena Rai

    2013-01-01

    Full Text Available Medical treatments for acne vulgaris include a variety of topical and oral medications. Poor compliance, lack of durable remission, and potential side effects are common drawbacks to these treatments. Therefore, there is a growing demand for a fast, safe, and side-effect-free novel therapy. Acne often improves after exposure to sunlight, and this has led to the development of laser and other light therapies resulting in the overall ease of treatment, with minimal adverse effects. A variety of light and laser devices has been used for the treatment of acne, including the potassium titanyl phosphate laser, the 585- and 595-nm pulsed dye lasers, the 1450-nm diode laser, radiofrequency devices, intense pulsed light sources, and photodynamic therapy using 5-aminolevulinic acid and indocyanine green. These devices are thought to target the underlying pathogenic factors such as propionibacterium acnes colonization, increased sebaceous gland activity, and the cutaneous inflammatory response. In this article, we review the current status of light- and laser-based treatment of acne.

  17. Acne Vulgaris Treated with Integrative Chinese Medicine Therapies Combined with Blue and Red LED Phototherapy: A Clinical Observation of 30 Cases%中医综合疗法联合红蓝光治疗寻常型痤疮30例

    Institute of Scientific and Technical Information of China (English)

    孙捷; 杜长明; 刘明珠

    2011-01-01

    目的 观察中医综合疗法联合红蓝光治疗寻常型痤疮的临床疗效.方法 将54例寻常型痤疮患者随机分为治疗组和对照组,对照组24例患者口服一清胶囊和外搽0.1%迪维霜,治疗组30例患者口服清热利湿化痰、凉血活血的中药汤剂,外用中药熏药和面膜,及采用红蓝光照射.2周为1个疗程.观察并比较治疗前后皮疹总评分和中医证候总评分的变化,以及两组痤疮愈显率和中医证候愈显率.结果 治疗后两组皮疹总评分和中医证候总评分均显著下降(P<0.01),治疗组皮疹总评分显著低于对照组(P<0.05);治疗组痤疮愈显率和中医证候愈显率显著高于对照组(P<0.05,或P<0.01).结论 中医综合疗法联合红蓝光疗法能显著改善寻常型痤疮患者的皮损情况及湿热证候.%Objective To observe the therapeutic effects of integrative Chinese medicine treatments combined with blue and red LED phototherapy in treating acne vulgaris. Methods Fifty-four patients with acne vulgaris were randomized into control group and treatment group. Twenty-four patients in the control group were treated with oral administration of Yiqing Capsules, a patent traditional Chinese medicine (TCM) , and external application of 0. 1% Diweishuang Emulsifiable Paste; while 30 patients in the treatment group were treated with TCM decoction for clearing heat, removing dampness, resolving phlegm,cooling blood, and activating blood circulation, and external application of TCM fumigation and TCM mask, as well as red and blue LED phototherapy. Before and after treatment, some indicators, including the total scores of rashes, and TCM syndrome as well as the recovery plus excellent efficacy rates of acne,and TCM syndrome, were observed and compared between the two groups. Results After treatment, the scores of rashes, and TCM syndrome were significantly decreased in the two groups compared with those before treatment (P<0. 01) ; furthermore, the scores of

  18. Quality of life, problem solving, focus of control and anger tendency in the patients with acne

    Directory of Open Access Journals (Sweden)

    Erman Bağcıoğlu

    2014-12-01

    Full Text Available Background and Design: In this study, we evaluated anxiety and depression levels, levels of problem solving, focus of control, tendency to anger and quality of life in patients with acne as well as the association between those parameters and the clinical features of acne. Materials and Methods: Fifty-two patients with mild to severe acne vulgaris and 46 healthy controls were enrolled. Acne severity was graded in all patients by a dermatologist. The Montgomery-Asberg Depression Rating Scale (MADRS, Hamilton Anxiety Rating Scale (HAM-A, Brief Symptom Inventory (BSI, Problem Solving Inventory (PSI, The State-Trait Anger Scale (STAS, Rotter’s Internal-External Focus of Control Scale (RIELCS and the Short Form 36-Item Health Survey (SF-36 were applied to all participants. Results: In our study, we found out that anxiety and depression scores were significantly higher in patients with acne vulgaris than in controls. In BSI, anxiety disorders, depression, interpersonal sensitivity, and paranoid thoughts scores were significantly higher in patients with acne than in controls. According to SF-36, physical role difficulty, general health and mental health scores were significantly lower in patients with acne. Conclusion: The results of our study support the previous findings suggesting that acne vulgaris leads to various psychiatric problems, such as depression and anxiety and, adversely affects quality of life of patients.

  19. Explore the relationship between TCM health maintenance and cosmetology according to investigation of facial acne vulgaris of college students in Tianjin%据“天津市大学生痤疮发病因素相关性调查”论中医养生与美容

    Institute of Scientific and Technical Information of China (English)

    杨帆; 夏庆梅; 孟静岩

    2012-01-01

    Objective: To study the prevalence and the related risk factors of facial acne vulgaris of college students in Tianjin and explore the contact between health of TCM and cosmetology. Methods: To conduct cross-sectional survey about the occurrance of acne grades in the studying students from 2006 to 2008 grade in Tianjin. Multi variate logistic analysis showed: lack of sleep, the addiction to fried or fatty foods, oily skin, the use of cosmetic products were risk factors. Conclusions: Risk factors of Acne occurrence are closely related to daily living habits, dietary habits, skin care.etc.%目的:通过对天津市大学生寻常痤疮的流行现况及相关危险因素的分析,探讨中医养生与美容的联系.方法:2008年9-11月对天津市2006-2008级在校大学生痤疮发病情况进行横断面问卷调查.多因素Logistic回归分析结果显示:睡眠不足、喜食油炸或肥腻食品、油性肌肤、混合性肌肤、经常使用彩妆化妆品为危险因素.结论:痤疮发生的危险因素与日常生活习惯、饮食、护理等养生方面有着密切的关系.

  20. Retinoid plus antimicrobial combination treatments for acne

    Directory of Open Access Journals (Sweden)

    Feneran A

    2011-07-01

    Full Text Available Ashley N Feneran1, William S Kaufman2, Tushar S Dabade1, Steven R Feldman1,3,41Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA; 2Medical College of Virginia, Richmond, VA, USA; 3Department of Pathology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, USA; 4Department of Public Health Sciences, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, USABackground: Acne vulgaris is a chronic disease with several pathogenic factors. Multiple medications are typically used that can lead to nonadherence and treatment failure. Combination medications target multiple pathways of acne formation and may offer therapeutic benefit.Purpose: To explore the efficacy and tolerability of combination retinoid plus antimicrobial treatments in acne vulgaris.Methods: A PubMed and Google search was conducted for combination therapies of clindamycin and tretinoin, with secondary analysis of related citations and references. Similar searches were completed for the combination medications of benzoyl peroxide plus clindamycin or erythromycin, and for the combination therapy of adapalene and benzoyl peroxide.Results: Combination clindamycin phosphate and tretinoin gel was found to be more efficacious than monotherapy of either drug or its vehicle for acne, including inflammatory acne, and has a greater onset of action than either drug alone. Clindamycin phosphate and tretinoin gel was well-tolerated, and adherence to its use exceeded that of using both medications in separate formulations. Benzoyl peroxide-containing combination medications with clindamycin or erythromycin were both more effective in the treatment of acne than either drug alone. Both medications were well-tolerated, with dry skin being the most common adverse effect.Conclusions: Combination medications have superior efficacy and adherence, and

  1. Acne scars in 18-year-old male adolescents: a population-based study of prevalence and associated factors*

    OpenAIRE

    Lauermann, Fernanda Tcatch; de Almeida Jr., Hiram Larangeira; Duquia, Rodrigo Pereira; Souza, Paulo Ricardo Martins; Breunig, Juliano de Avelar

    2016-01-01

    Background Acne vulgaris is a pilosebaceous follicle disorder affecting over 85% of adolescents to some degree. It frequently causes psychological distress that may persist into adulthood due to scarring. Little information about post-acne scarring epidemiology is available. Objectives To describe prevalence, distribution patterns and associated factors of acne scarring in young males, drawing on a representative population sample from a southern Brazilian city. Methods A cross-sectional stud...

  2. Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris.

    Science.gov (United States)

    Baumann, Leslie S; Oresajo, Christian; Yatskayer, Margarita; Dahl, Amanda; Figueras, Kristian

    2013-03-01

    This study evaluated the tolerance and efficacy of 2 facial skin products in subjects with acne using the following acne treatments: 1) treatment A, a combination of salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid, and 2) treatment B (BenzaClin®, clindamycin 1% and benzoyl peroxide 5% gel). The treatment design included the split-face application of treatment A and treatment B and the full-face application of the cleanser, moisturizer, and sunscreen. Data were collected through physician visual assessments, subject irritation questionnaires and assessments, along with clinical photography. Results showed similar tolerance and efficacy for both treatments.

  3. Proteomic identification of secreted proteins of Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    Holland Carsten

    2010-08-01

    Full Text Available Abstract Background The anaerobic Gram-positive bacterium Propionibacterium acnes is a human skin commensal that resides preferentially within sebaceous follicles; however, it also exhibits many traits of an opportunistic pathogen, playing roles in a variety of inflammatory diseases such as acne vulgaris. To date, the underlying disease-causing mechanisms remain ill-defined and knowledge of P. acnes virulence factors remains scarce. Here, we identified proteins secreted during anaerobic cultivation of a range of skin and clinical P. acnes isolates, spanning the four known phylogenetic groups. Results Culture supernatant proteins of P. acnes were separated by two-dimensional electrophoresis (2-DE and all Coomassie-stained spots were subsequently identified by MALDI mass spectrometry (MALDI-MS. A set of 20 proteins was secreted in the mid-exponential growth phase by the majority of strains tested. Functional annotation revealed that many of these common proteins possess degrading activities, including glycoside hydrolases with similarities to endoglycoceramidase, β-N-acetylglucosaminidase and muramidase; esterases such as lysophospholipase and triacylglycerol lipase; and several proteases. Other secreted factors included Christie-Atkins-Munch-Petersen (CAMP factors, glyceraldehyde 3-phosphate dehydrogenase (GAPDH, and several hypothetical proteins, a few of which are unique to P. acnes. Strain-specific differences were apparent, mostly in the secretion of putative adhesins, whose genes exhibit variable phase variation-like sequence signatures. Conclusions Our proteomic investigations have revealed that the P. acnes secretome harbors several proteins likely to play a role in host-tissue degradation and inflammation. Despite a large overlap between the secretomes of all four P. acnes phylotypes, distinct differences between predicted host-tissue interacting proteins were identified, providing potential insight into the differential virulence

  4. Acne in hirsute women

    Science.gov (United States)

    Pupovci, Hatixhe Latifi; Berisha, Violeta Lokaj; Goçi, Aferdita Uka; Gerqari, Antigona

    2014-01-01

    Introduction Acne and hirsutism are common manifestations of hyperandrogenism. Aim To investigate whether or not acne is present in women with hirsutism, associated with different clinical, endocrine and ultrasonographic features. Material and methods The prospective study included 135 women with hirsutism, aged 14–46 years. We measured the levels of hormones with radioimmunoassay/immunoradiometric assay methods. Results Acne were present in 63 (47.6%) women with hirsutism. Sixty women had mild forms of acne, including: whiteheads, blackheads, papules and pustules. Only 3 women had moderate to severe acne, including nodules. In a group of women with hirsutism and acne, 6 (9.5%) were obese. In our study we found a high prevalence of androgen excess among hirsute women with acne: total testosterone was increased in 79%, free testosterone in 20.6%, androstenedione in 69.8%, dehydroepiandrosterone sulfate (DHEAS) in 30.1%, 17-OH-progesterone 68.2% and sex hormone-binding globulin (SHBG) was decreased in 33.3% of women. Women with hirsutism and acne have received oral contraceptives for a year, without or in a combination with other medication. Thirty-four (53.9%) women have shown improvement in hirsutism and acne. Conclusions In this study we found a high prevalence of acne in hirsute women. The prevalence of acne was higher in polycystic ovarian syndrome. Since these women have associated endocrine changes it is important to correct them with hormonal therapy. PMID:25610349

  5. In vitro antimicrobial activity of benzoyl peroxide against Propionibacterium acnes assessed by a novel susceptibility testing method.

    Science.gov (United States)

    Okamoto, Kazuaki; Ikeda, Fumiaki; Kanayama, Shoji; Nakajima, Akiko; Matsumoto, Tatsumi; Ishii, Ritsuko; Umehara, Masatoshi; Gotoh, Naomasa; Hayashi, Naoki; Iyoda, Takako; Matsuzaki, Kaoru; Matsumoto, Satoru; Kawashima, Makoto

    2016-06-01

    Benzoyl peroxide (BPO), a therapeutic agent for acne vulgaris, was assessed for in vitro antimicrobial activity against Propionibacterium acnes using a novel broth microdilution testing that improved BPO solubility. We searched for a suitable culture medium to measure the minimum inhibitory concentration (MIC) of BPO against P. acnes and finally found the Gifu anaerobic medium (GAM) broth supplemented with 0.1(v/v)% glycerol and 2(v/v)% Tween 80, in which BPO dissolved up to 1250 μg/mL and P. acnes grew well. The MICs and minimum bactericidal concentrations (MBCs) of BPO against 44 clinical isolates of P. acnes collected from Japanese patients with acne vulgaris were determined by our testing method using the supplemented GAM broth. The MICs of BPO were 128 or 256 μg/mL against all isolates of P. acnes regardless of susceptibility to nadifloxacin or clindamycin. The MBCs of BPO were also 128 or 256 μg/mL against the same isolates. Moreover, BPO at the MIC showed a rapid bactericidal activity against P. acnes ATCC11827 in time-kill assay. In conclusion, we could develop a novel assay for the MIC and MBC determinations of BPO against P. acnes, which is reliable and reproducible as a broth microdilution testing and the present results suggest that BPO has a potent bactericidal activity against P. acnes.

  6. Efficacy of an Unani Formulation in Reducing Post Inflammatory Acne Hyperpigmentation Marks- A Clinical Study

    Directory of Open Access Journals (Sweden)

    Shabiya Sultana

    2015-10-01

    Full Text Available There is no single malady which causes supplementary psychic disturbance and more general insecurity and feeling of inferiority than acne vulgaris with post inflammatory acne pigmentation marks does. It is strongly associated with depression and anxiety. In addition to individuals with little objective evidence acne with post inflammatory acne hyperpigmentation marks may endure severe subjective impairment, greatly affecting their health related quality of life. Unani System of Medicine contains treatise of basic and compound formulations that can be administered orally and locally in improving post inflammatory acne hyperpigmentation marks. To evaluate the efficacy of a poly herbal Unani formulation in improving post inflammatory acne hyperpigmentation marks. The study was observational self-comparison before and after treatment on 32 female patients. The separate powders of drugs; Shūnīz, Būra Armanī, Naushādar sieved and mixed with Sirka (vinegar and prepared a Unani formulation and were applied topically. All the patients were assessed for change in pigmentation marks of face by using “Visual arbitrary scale for acne hyperpigmentation marks”. In present study out of 32 acne patients 20 (62.5% reported decrease in acne hyperpigmentation marks. The effect of drug was significant (p<0.01 statistically and clinically both. In the present study it was concluded that the used Unani formulation was much effective in improving post inflammatory acne hyperpigmentation marks.

  7. Acne: more than skin deep

    OpenAIRE

    Ayer, J; Burrows, N

    2006-01-01

    Acne is one of the most prevalent skin conditions affecting teenagers. It is a disease of the pilosebaceous unit. Blockage of sebaceous glands and colonisation with Proionobacterium acnes leads to acne. Grading the severity of acne helps to determine the appropriate treatment. Treatment of acne should be started as early as possible to minimise the risk of scarring and adverse psychological effects. It should be tailored to the individual patient, the type of acne, its severity, the patient's...

  8. Hormonal therapy for acne.

    Science.gov (United States)

    George, Rosalyn; Clarke, Shari; Thiboutot, Diane

    2008-09-01

    Acne affects more than 40 million people, of which more than half are women older than 25 years of age. These women frequently fail traditional therapy and have high relapse rates even after isotretinoin. Recent advances in research have helped to delineate the important role hormones play in the pathogenesis of acne. Androgens such as dihydrotestosterone and testosterone, the adrenal precursor dehydroepiandrosterone sulfate, estrogens, growth hormone, and insulin-like growth factors may all contribute to the development of acne. Hormonal therapy remains an important part of the arsenal of acne treatments available to the clinician. Women dealing with acne, even those without increased serum androgens, may benefit from hormonal treatments. The mainstays of hormonal therapy include oral contraceptives and antiandrogens such as spironolactone, cyproterone acetate, or flutamide. In this article, we discuss the effects of hormones on the pathogenesis of acne, evaluation of women with suspected endocrine abnormalities, and the myriad of treatment options available. PMID:18786497

  9. Research of Epidemiology of Acne Vulgaris of Syndrome Differentiation and Cause of Disease%寻常痤疮辨证与发病的流行病学研究

    Institute of Scientific and Technical Information of China (English)

    李灿新; 成改霞; 蔡东华; 闵莉

    2006-01-01

    寻常痤疮(Acne Vulgaris,AV)是一种毛囊皮脂腺的慢性炎症性疾病,以粉刺、丘疹、脓疱、结节、囊肿及瘢痕为其特征,常伴皮脂溢出,多发生于青春期男女。

  10. Therapeutic effect of blue and red LED phototherapy combined with traditional Chinese medical mask on acne vulgaris%窄谱红蓝光治疗仪联合中药面膜治疗寻常性痤疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘乐; 李百灵; 陈文慧; 李伯埙

    2012-01-01

    Objective To evaluate the therapeutic effect of the blue and red light-emitting diode (LED) phototherapy combined with traditional Chinese medical mask for acne vulgaris.Methods 94 patients with acne vulgaris were randomly divided into three groups, all groups were treated with "Fu Fang Zhen Zhu An Chuang" tablets, treatment group (31cases)was treated with traditional Chinese medical mask combined with blue and red LED phototherapy control group 1 was treated with blue and red LED phototherapy,control group 2 was treated with traditional Chinese medical mask twice one week.The therapeutic effect of both three groups was determined four weeks later. Results The effective ratio of the treatment group (80.00%) were significantly higher than that in control groups (66.66%,64.51%),the difference between the three grups (x21=4.23,x22=4,85,P<0,01). Conclusion The blue and red LED phototherapy combined with traditional Chinese medical mask has a marked effect on inflammatory acne lesions and seems sufficient for the treatment of acne,the course of treatment could be shorted and adverse effects could be cut down.%目的:探讨蓝光(417nm)和红光(630nm)交替照射治疗轻中度痤疮的疗效.方法:将94例轻中度痤疮患者随机分为治疗组、对照1组和对照2组,共三组.治疗组采用红蓝光照射联合中药面膜;对照1组单用红蓝光照射;对照2组单用自制中药面膜敷脸,均2次/周,三组均外用痤疮洗剂,口服复方珍珠暗疮片,共4周.结果:治疗组总有效率为80.00%,对照1组、对照2组总有效率分别为66.66%、64.51%,治疗组总有效率与对照组比较差异有统计学意义(x21=4.23,x22=4.85,P<0.01),对照1组和对照2组比较差异无统计学意义(x2=12.34,P>0.05).结论:417nm蓝光和633nm红光联合中药面膜对轻中度痤疮的治疗安全、有效,可以缩短疗程,提高治愈率.

  11. 锋勾针排脓放血对结节型痤疮皮损修复作用的研究%Study on Pus-draining and Bloodletting with Sharp-hook Needle in Repairing Skin Lesions in Acne Vulgaris of Nodules

    Institute of Scientific and Technical Information of China (English)

    万怡

    2015-01-01

    目的:观察锋勾针排脓放血与单纯排脓治疗对结节型痤疮溃疡皮损的修复作用。方法选取20对结节型痤疮皮损,分为治疗组和对照组,治疗组采用锋勾针排脓放血治疗,对照组采用锋勾针排脓治疗。患者面部选择2枚结节型痤疮皮损,其溃疡面积与皮损面积都相同,1枚行锋勾针排脓放血法治疗,另1枚行锋勾针单纯排脓治疗,观察比较两组1星期内每天的溃疡面积和皮损面积变化,软硬度变化。结果治疗组溃疡皮损面积缩小情况优于对照组(P<0.05),治疗组软硬度变化情况优于对照组(P<0.05)。结论锋勾针挑割排脓放血治疗寻常痤疮对痤疮溃疡皮损面积修复能力较单纯排脓更强。%ObjectiveTo observe the effect of pus-draining and bloodletting with sharp-hook needle in repairing the skin lesions in acne vulgaris of nodules type.MethodTwenty pairs of skin lesions caused by acne vulgaris of nodules type were divided into a treatment group and a control group. The treatment group was intervened by pus-draining and bloodletting with sharp-hook needle, while the control group was by pus-draining with sharp-hook needle. Two facial skin lesions of same size were selected from each patient to respectively receive pus-draining and bloodletting with sharp-hook needle or pus-drainage alone. The changes of lesion size and hardness in a week were observed and compared.ResultThe reducing of lesion size was more significant in the treatment group than that in the control group (P<0.05), and the improvement of hardness of the lesions in the treatment group was also more significant in the treatment group than that in the control group (P<0.05).ConclusionPus-draining and bloodletting with sharp-hook needle can produce amore significant effect in repairing skin lesions in acne vulgaris than pus-draining alone.

  12. 红/蓝光光动力联合五味消毒饮治疗中重度寻常性痤疮临床观察及护理%Clinical effects of the combination of red/blue light photodynamic and wuweixiaoduyin in treatment of patients with acne vulgaris and its nursing experiences

    Institute of Scientific and Technical Information of China (English)

    杨波; 代晓莉; 王淑秀

    2011-01-01

    Objective To explore the clinical effects of the combination of red/blue light photodynamic and wuweixiaoduyin in treatment of patients with acne vulgaris and its nursing requirements. Methods The red/blue light photodynamic therapy device was used to treatment with acne vulgaris 2 times per week for the treatment group,2 blue light and 2 red light were alternately administrated for 20 min in each time,48 J/cm2.AII of the patients in the treatment group drink wuweixiaoduyin every day The light photodynamic continued 4 weeks. On the other hand, the patients in the control group just drink wuweixiaoduyin every day. Results After treatments cases were cured completely,31 cases were improved significantly, 12 cases were improved effectively, and 3 cases were treated with no effect in the treatment group. However, one case was cured completely,24 cases were improved significant,20 cases were improved effectively,and 13 cases were treated with no effect in the control group. The effective rates in the treatment group were significantly higher than those in the control group (P<0.05). Conclusions The combination of red/blue light photodynamic and wuweixiaoduyin was a non-invasive.safe and effective method in treatment of acne vulgaris by, which should be suggested in clinical experiences.%目的:研究红/蓝光光动力联合五味消毒饮治疗寻常性痤疮的临床效果及护理要求。方法:治疗组采用红/蓝光光动力痤疮治疗仪,每周治疗2次,2次蓝光2次红光交替进行,疗程4周,每次治疗时间20min,剂量48 J/cm2。同时口服五味消毒饮,每日1剂;对照组仅口服五味消毒饮,每日1剂。结果:治疗组痊愈4例、显效31例、有效12例、无效3例;对照组痊愈1例、显效24例、有效20例、无效1 3例,治疗组有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:红/蓝光光动力联合五味消毒饮治疗寻常性痤疮为一种无创、安全、有效的新方法。

  13. Hormone therapy in acne

    OpenAIRE

    Chembolli Lakshmi

    2013-01-01

    Underlying hormone imbalances may render acne unresponsive to conventional therapy. Relevant investigations followed by initiation of hormonal therapy in combination with regular anti-acne therapy may be necessary if signs of hyperandrogenism are present. In addition to other factors, androgen-stimulated sebum production plays an important role in the pathophysiology of acne in women. Sebum production is also regulated by other hormones, including estrogens, growth hormone, insulin, insulin-l...

  14. Acne and anticonvulsants.

    OpenAIRE

    Greenwood, R; Fenwick, P B; Cunliffe, W J

    1983-01-01

    The severity of acne and rate of excretion of sebum were assessed in 243 patients with epilepsy taking various anticonvulsants who were in hospital long term and in matched controls derived from a normal population of 2176 people. Neither the prevalence of acne nor the sebum excretion rate significantly increased in the patients compared with the controls or in patients taking phenytoin compared with those not. It is concluded that anticonvulsant treatment does not cause acne.

  15. Acne in hirsute women

    OpenAIRE

    Lumezi, Besa Gacaferri; Pupovci, Hatixhe Latifi; Berisha, Violeta Lokaj; Goçi, Aferdita Uka; Gerqari, Antigona

    2014-01-01

    Introduction Acne and hirsutism are common manifestations of hyperandrogenism. Aim To investigate whether or not acne is present in women with hirsutism, associated with different clinical, endocrine and ultrasonographic features. Material and methods The prospective study included 135 women with hirsutism, aged 14–46 years. We measured the levels of hormones with radioimmunoassay/immunoradiometric assay methods. Results Acne were present in 63 (47.6%) women with hirsutism. Sixty women had mi...

  16. 壳聚糖抗菌成膜喷雾剂联合多功能治疗仪治疗中度痤疮临床观察%Clinical Observation of Chitosan Antiseptic Material Combined with Multifunctional Therapeutical in the Treatment of Moderate Acne Vulgaris

    Institute of Scientific and Technical Information of China (English)

    侯艳霞; 夏华; 韩旭; 李定超; 蒋靖

    2014-01-01

    Objective To evaluate the ef icacy of chitosan antiseptic material combined with multifunctional therapeutical in the treatment of moderate acne vulgaris. Methods The 50 patients were randomly divided into two groups, each group included 25 patients. The treatment group was given chitosan antiseptic material combined with multifunctional therapeutical while the control group was only given multifunctional therapeutical. The therapeutic ef ect was observed at the end of the 4th week after the treatment. Results After 4 weeks,the quantity of skin eruption in both groups was apparently lower than before but that of treatment group was apparently lower than that in control group.Besides, the ef ective rate in the treatment group (84.00%) was higher than that in the control group (56.00%).The dif erences were statistical y significant ( <0.05).No side effects were observed. Conclusion Chitosan antiseptic material combined with multifunctional therapeutical is ef ective in the treatment of moderate acne vulgaris with lit le adverse reaction.%目的:评价壳聚糖抗菌成膜喷雾剂联合多功能治疗仪治疗中度痤疮的临床疗效。方法将入选的50例中度痤疮患者随机分为两组,各25例。治疗组予壳聚糖抗菌成膜喷雾剂喷涂联合多功能治疗仪治疗,对照组仅予多功能治疗仪治疗,均在治疗4w后判定临床疗效。结果治疗4w后,治疗组和对照组的皮损总数均明显低于治疗前,而且治疗组明显少于对照组,治疗组有效率(84.00%)优于对照组(56.00%),差异均有统计学意义(<0.05)。两组患者也均未见明显的不良反应。结论壳聚糖抗菌成膜喷雾剂联合多功能治疗仪治疗中度痤疮有较好的临床疗效,且无明显不良反应。

  17. Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne:

    OpenAIRE

    Aberer, W.; Kränke, Birger; Mayr-Kanhäuser, Sigrid

    2008-01-01

    Background: With the increase in antibiotic-resistant strains of microorganisms in acne lesions, the search for alternative treatment methods has become important. We studied the efficacy of a combination of the antiseptic substances octenidine dihydrochloride and 2-phenoxyethanol (O/P) in mild to moderate inflammatory acne vulgaris. Methods: Thirty patients were instructed to apply O/P once or twice daily for a 6-week treatment period. Determination of efficacy included the numerical documen...

  18. The Clinical Efficacy of Blue Red Led Phototherapy Combined with Jinhua Xiaocuo Pills and Chloramphenicol Tincture on the Treatment of Acne Vulgaris%红蓝光治疗仪联合金花消痤丸及氯霉素酊治疗寻常痤疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    张玉红

    2013-01-01

    Objective To observe the clinical efficacy of blue and red led phototherapy combined with jinhua xiaocuo pills and chloramphenicol tincture on the treatment of patients with acne vulgaris. Methods Patients were randomly divided into two groups,60 patients of treatment group were treated by red blue phototherapy combined with jinhua xiaocuo pills and chloramphenicol tincture, 60 patients of control group were treated with jinhua xiaocuo pills and chloramphenicol tincture. Acne was assessed at baseline and 4 weeks later. Results The effective rate in treating group was 91.67% and control group was 65.00% (P <0. 05) ;Two subjects reported side effects of the light treatment in the form of mild facial erythema, itching and scaling. Conclusion Blue and red led phototherapy combined with jinhua xiaocuo pills and chlorampenicol tincture on the treatment of acne is superior to jinhua xiaocuo pills and chlorampenicol tincture.%目的 观察红蓝光治疗仪联合金花消痤丸及氯霉素酊治疗寻常痤疮的临床疗效.方法 将入选患者随机分成两组,治疗组60例用红蓝光照射联合口服金花消痤丸剂外用氯霉素酊治疗,对照组60例仅口服金花消痤丸剂外用氯霉素酊治疗,方法同治疗组,疗程均为4周.结果 治疗结束后,治疗组有效率91.67%,对照组65.00%,差异有统计学意义(P<0.05);治疗组有2例经红蓝光照射后面部皮肤出现轻度潮红、瘙瘁和脱屑.结论 红蓝光治疗仪联合口服金花消痤丸及外用氯霉素酊治疗痤疮起效快、有效率高、复发率低、值得临床选用.

  19. Avaliação dos efeitos adversos clínicos e alterações laboratoriais em pacientes com acne vulgar tratados com isotretinoína oral Evaluation of clinical adverse effects and laboratory alterations in patients with acne vulgaris treated with oral isotretinoin

    OpenAIRE

    Maria de Fátima de Medeiros Brito; Iara Pessoa Sant'Anna; Juliana Cordeiro Souza Galindo; Lígia Helena Pessoa de Melo Rosendo; Josemir Belo dos Santos

    2010-01-01

    FUNDAMENTOS: A isotretinoína oral revolucionou o manejo da acne. Os efeitos adversos observados, durante o tratamento, são divididos em dois grupos: mucocutâneos e sistêmicos. Anormalidades laboratoriais, principalmente, as dislipidemias e aumento das enzimas hepáticas são relatados. OBJETIVO: Avaliar a tolerabilidade da isotretinoína oral, com atenção, no metabolismo lipídico, função hepática e reações adversas clínicas. MÉTODOS: Foram incluídos 150 pacientes com diagnóstico clínico de acne ...

  20. Suppression of Propionibacterium acnes Infection and the Associated Inflammatory Response by the Antimicrobial Peptide P5 in Mice.

    Directory of Open Access Journals (Sweden)

    Sunhyo Ryu

    Full Text Available The cutaneous inflammation associated with acne vulgaris is caused by the anaerobic bacterium Propionibacterium acnes through activation of the innate immune system in the skin. Current standard treatments for acne have limitations that include adverse effects and poor efficacy in many patients, making development of a more effective therapy highly desirable. In the present study, we demonstrate the protective effects of a novel customized α-helical cationic peptide, P5, against P. acnes-induced inflammatory responses in vitro and in vivo. Application of P5 significantly reduced expression of two inflammatory cytokines IL-8 and TNF-α in P. acnes-treated primary human keratinocytes, where P5 appeared to act in part by binding to bacterial lipoteichoic acid, thereby suppressing TLR2-to-NF-κB signaling. In addition, in a mouse model of acne vulgaris, P5 exerted both anti-inflammatory and antimicrobial effects against P. acnes, but exerted no cytotoxic effects against skin cells. These results demonstrate that P5, and perhaps other cationic antimicrobial peptides, offer the unique ability to reduce numbers P. acnes cells in the skin and to inhibit the inflammation they trigger. This suggests these peptides could potentially be used to effectively treat acne without adversely affecting the skin.

  1. Teens and Acne Treatment

    Science.gov (United States)

    ... Español Text Size Email Print Share Teens and Acne Treatment Page Content Article Body I'm starting to ... peroxide wash, lotion, or gel—the most effective acne treatment you can get without a prescription. It helps ...

  2. Postadolescent acne in females.

    Science.gov (United States)

    Holzmann, R; Shakery, K

    2014-01-01

    Acne in the adult female often presents as a chronic condition that can have a considerable negative psychological, social and emotional impact on the affected individual. Estimated prevalence rates of adult female acne vary widely according to study type. Case reports and clinical examinations estimate the prevalence of clinical acne at 10-12%, while survey estimates of physiological disease states are as high as 54%. Two subtypes of adult female acne may be defined according to time of onset: 'persistent' and 'late-onset', accounting for approximately 80 and 20% of cases, respectively. Postadolescent acne is generally mild-to-moderate in severity and presents with more inflammatory lesions and fewer comedones compared to adolescent acne. Furthermore, the impact of acne on the quality of life is often greater in adult females than in younger individuals. Despite these important differences, the key principles of acne treatment in the adult female do not differ significantly from those of other age groups. However, specific characteristics relating to the adult female should be considered when selecting a treatment regimen. PMID:24280643

  3. Moisturizers for Acne

    Science.gov (United States)

    Chularojanamontri, Leena; Tuchinda, Papapit; Kulthanan, Kanokvalai

    2014-01-01

    Acne is a chronic inflammatory disease of the pilosebaceous unit that affects almost all teenagers. Different treatments offer different modes of action, but aim to target acne pathology. Topical therapies, such as benzoyl peroxide, retinoids, antibiotics with alcohol-based preparations, and salicylic acid, can cause skin irritation resulting in a lack of patient adherence. Some physicians recommend patients use moisturizers as adjunctive treatment of acne, especially when either topical benzoyl peroxide or a retinoid is prescribed. Furthermore, some evidence shows that moisturizers can contribute independently to improve signs and symptoms of acne. Moisturizers contain three main properties, which are occlusive, humectant, and emollient effects. Currently, many moisturizers claim to be suitable for acne treatment. This article aims to provide a review of the active ingredients and properties of those moisturizers. Fifty-two moisturizers for acne were included for analysis. Most of the products (92%) have anti-inflammatory properties apart from occlusive, humectant, and emollient effects. Anti-acne medications, including salicylic acid, benzoyl peroxide, and retinol, were found respectively in 35, 10, and 8 percent of the moisturizer products containing anti-inflammatory properties. More than half of the products contain dimethicone and/or glycerin for its moisturizer property. Aloe vera and witch hazel are botanical anti-inflammatories that were commonly found in this study. Scientific data regarding some ingredients are discussed to provide a guide for physicians in selecting moisturizers for acne patients. PMID:24847408

  4. [Charles Bukowski's acne].

    Science.gov (United States)

    Bahmer, F A; Bahmer, J A

    2012-04-01

    In his autobiography, Charles Bukowski (1920-1994) describes his severe acne conglobata, his experience with therapy, family conflicts and emotional tension. Despite the stigmatization by his acne scars, Bukowski became a philobatic writer and a true chronist of the American way of life in the second half of the 20th century, writing in a coarse and obscene language.

  5. Clinical observation of baixianxiatare tablet combined with doxycycline on treating of acne vulgaris%百癣夏塔热片联合多西环素治疗寻常性痤疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    王江涛; 冯佳汉

    2012-01-01

    Objective Aim To evaluate the efficacy of Baixianxiatare tablet combined with Doxycycline on treating of acne vuigaris. Methods 100 patients with acne vuigaris were divided into two groups randomly, the treatment group (50 patients) and the control group (50 patients). The treatment group was treated by Doxycycline plus Baixianxiatare tablet, and the control group treated by Doxycycline alone. Results The effective rate in the treatment group and control group was 78.0% and 60.0% respectively, and the effect of the treatment group was better than that of the control group. Conclusion The combination of Baixianxiatare tablet and Doxycycline is a safe and effective way of treating acne vuigaris. It's worthy to be popularized.%目的:观察百癣夏塔热片联合多西环素治疗寻常性痤疮的临床疗效.方法:将100例寻常性痤疮患者随机分为两组,治疗组50例,对照组50例,治疗组采用口服百癣夏塔热片,同时口服多西环素;对照组单独口服多西环素,两组疗程均为6周.结果:治疗组有效率78.0%,对照组有效率为60.0%,治疗组有效率高于对照组(P<0.05).结论:百癣夏塔热片联合多西环素治疗寻常性痤疮,疗效显著,副作用少,值得临床推广应用.

  6. Is benzoyl peroxide 3% topical gel effective and safe in the treatment of acne vulgaris in Japanese patients? A multicenter, randomized, double-blind, vehicle-controlled, parallel-group study.

    Science.gov (United States)

    Kawashima, Makoto; Hashimoto, Hirofumi; Alio Sáenz, Alessandra B; Ono, Makoto; Yamada, Masahiro

    2014-09-01

    Benzoyl peroxide (BPO) as an anti-acne medication is not yet approved in Japan. This study evaluated the efficacy and safety of a once-daily topical application of BPO 3% gel versus an inert vehicle gel in Japanese acne patients. Three hundred and sixty patients were randomized to receive BPO 3% or vehicle for 12 weeks. The primary efficacy end-point was absolute change in number of total lesions (TL) from baseline to week 12 to demonstrate the superiority of BPO 3% versus vehicle. Secondary efficacy end-points were absolute and percent change in TL, inflammatory lesions (IL), non-inflammatory lesions (non-IL) and Investigator's Static Global Assessment (ISGA). Change in TL counts from baseline to week 12 for BPO 3% was superior to vehicle (difference, -21.0; P BPO 3% at all study visits. The proportion of patients with improvement in ISGA scores was significantly higher with BPO 3% than with vehicle from week 2. All adverse events were mild or moderate. Adverse drug-related reactions were higher for BPO 3% (30%) than with vehicle (5%). Local tolerability scores of grade 1 or more (slight to moderate) were more frequent with BPO 3% than vehicle with the most significant differences observed in dryness (56% vs 27% at week 1-4), peeling (19% vs 9% at week 1-2) and burning/stinging (58% vs 15% at week 1-12). These results indicate that BPO 3% is effective while maintaining a favorable safety and tolerability profile in Japanese acne patients.

  7. You Are What You Eat: RCTs show a low glycemic index diet improves facial acne

    OpenAIRE

    Kazemi, Tiana

    2015-01-01

    An evidence-based literature review was conducted in order to identify human clinical trials that assess the effect of a low glycemic index diet on facial acne severity (Acne vulgaris). Of the twenty-one studies identified, three met the inclusion criteria of randomized-controlled clinical trials (RCTs) with a primary endpoint of changes in number and severity of acne lesions and were included for final analysis.7-9 During the trials, mean glycemic load in control groups ranged from 157 to 20...

  8. URIC ACID: A NEW ANTIOXIDANT IN PATIENTS WITH PEMPHIGUS VULGARIS

    OpenAIRE

    Maryam Yousefi; Hoda Rahimi; Behrooz Barikbin; Parviz Toossi; Sara Lotfi; Mehdi Hedayati; Shima Younespour

    2011-01-01

    Background: Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, for example, atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus, and alopecia areata. ROS has an important role in the inflammation process. In PV, increased production of ROS leads to decline of antioxidants in plasma and red blood cells which results in oxidative stress. We aimed to evaluate the level of these antioxidants in PV patie...

  9. Hormonal therapies in acne.

    Science.gov (United States)

    Shaw, James C

    2002-07-01

    Hormones, in particular androgen hormones, are the main cause of acne in men, women, children and adults, in both normal states and endocrine disorders. Therefore, the use of hormonal therapies in acne is rational in concept and gratifying in practice. Although non-hormonal therapies enjoy wide usage and continue to be developed, there is a solid place for hormonal approaches in women with acne, especially adult women with persistent acne. This review covers the physiological basis for hormonal influence in acne, the treatments that are in use today and those that show promise for the future. The main treatments to be discussed are oral contraceptives androgen receptor blockers like spironolactone and flutamide, inhibitors of the enzyme 5 alpha-reductase and topical hormonal treatments. PMID:12083987

  10. Evaluation and Management of Acne.

    Science.gov (United States)

    Botros, Paul A; Tsai, Gary; Pujalte, George G A

    2015-12-01

    Acne is a common complaint in the primary care clinics. It has not only physical implications but also psychological. This article discusses the epidemiology, pathophysiology, and criteria for making the diagnosis. It also discusses endocrine disorders that may be the cause of acne. Treatment and management are discussed by subtype. Acne mechanica or sports-related acne is also discussed. PMID:26612368

  11. Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin.

    Directory of Open Access Journals (Sweden)

    Philippe A Grange

    2009-07-01

    Full Text Available Acne vulgaris is a chronic inflammatory disorder of the sebaceous follicles. Propionibacterium acnes (P. acnes, a gram-positive anareobic bacterium, plays a critical role in the development of these inflammatory lesions. This study aimed at determining whether reactive oxygen species (ROS are produced by keratinocytes upon P. acnes infection, dissecting the mechanism of this production, and investigating how this phenomenon integrates in the general inflammatory response induced by P. acnes. In our hands, ROS, and especially superoxide anions (O2(*-, were rapidly produced by keratinocytes upon stimulation by P. acnes surface proteins. In P. acnes-stimulated keratinocytes, O2(*- was produced by NAD(PH oxidase through activation of the scavenger receptor CD36. O2(*- was dismuted by superoxide dismutase to form hydrogen peroxide which was further detoxified into water by the GSH/GPx system. In addition, P. acnes-induced O2(*- abrogated P. acnes growth and was involved in keratinocyte lysis through the combination of O2(*- with nitric oxide to form peroxynitrites. Finally, retinoic acid derivates, the most efficient anti-acneic drugs, prevent O2(*- production, IL-8 release and keratinocyte apoptosis, suggesting the relevance of this pathway in humans.

  12. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

    Directory of Open Access Journals (Sweden)

    Melnik BC

    2015-07-01

    Full Text Available Bodo C Melnik Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Germany Abstract: Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet. Three major food classes that promote acne are: 1 hyperglycemic carbohydrates, 2 milk and dairy products, 3 saturated fats including trans-fats and deficient ω-3 polyunsaturated fatty acids (PUFAs. Diet-induced insulin/insulin-like growth factor (IGF-1-signaling is superimposed on elevated IGF-1 levels during puberty, thereby unmasking the impact of aberrant nutrigenomics on sebaceous gland homeostasis. Western diet provides abundant branched-chain amino acids (BCAAs, glutamine, and palmitic acid. Insulin and IGF-1 suppress the activity of the metabolic transcription factor forkhead box O1 (FoxO1. Insulin, IGF-1, BCAAs, glutamine, and palmitate activate the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1, the key regulator of anabolism and lipogenesis. FoxO1 is a negative coregulator of androgen receptor, peroxisome proliferator-activated receptor-γ (PPARγ, liver X receptor-α, and sterol response element binding protein-1c (SREBP-1c, crucial transcription factors of sebaceous lipogenesis. mTORC1 stimulates the expression of PPARγ and SREBP-1c, promoting sebum production. SREBP-1c upregulates stearoyl-CoA- and Δ6-desaturase, enhancing the proportion of monounsaturated fatty acids in sebum triglycerides. Diet-mediated aberrations in sebum quantity (hyperseborrhea and composition (dysseborrhea promote Propionibacterium acnes overgrowth and biofilm formation with overexpression of the virulence factor triglyceride lipase increasing follicular levels of free palmitate and oleate. Free palmitate functions as a “danger signal,” stimulating toll-like receptor-2-mediated inflammasome activation with interleukin-1β release, Th17 differentiation, and interleukin-17-mediated keratinocyte

  13. Acne fulminans incapacitante Disabling Acne Fulminans

    OpenAIRE

    Tiago Pina Zanelato; Gabriela Maria Abreu Gontijo; Célia Antônia Xavier de Moares Alves; Jacqueline Campoi Calvo Lopes Pinto; Paulo Rowilson Cunha

    2011-01-01

    Acne fulminans é uma manifestação rara, que pode ocorrer durante a evolução da acne vulgar, principalmente, em adolescentes masculinos. Uso de isotretinoína, testosterona, e reações imunológicas exacerbadas no organismo são desencadeantes relacionados. Sinais, sintomas e alterações laboratoriais como: febre, hepatomegalia, poliartralgia, leucocitose, plaquetose, aumento de provas inflamatórias e transaminases, são característicos. A cintilografia óssea pode detectar lesões líticas em vários s...

  14. Serum Growth Hormone and Insulin-Like Growth Factor-1 Levels in Women with Postadolescent Acne

    Directory of Open Access Journals (Sweden)

    Mualla Polat

    2010-06-01

    Full Text Available Background and Design: Acne vulgaris is an inflammatory disease of pilosebaceous unit. It usually starts after puberty but may continue into adulthood. We studied Growth hormone (GH and insulin-like growth factor (IGF-1 levels in women patients with acne vulgaris in whom all other hormon levels were normal. We aimed to show any relation of the acne vulgaris lesion type and GH and IGF-1 levels. Material and Method: The study conducted on the postadolesance period woman patients applying to out patient dermatology department with complaint of acne symptoms between Semtember 2005 and July 2006. All other hormonal parameters were normal in patients. 25 healthy similar age women were accepted as control. IGF-I and GH were quantified by solid-phase competitive chemiluminescence assays. Results: There was no difference according to age between the groups (p=0.726. The mean IGF-1 level was 336.5±112.88 ng/ml in patients and 194±31.32 ng/ml in control; the difference was significantly important (p=0.000. The mean GH level was 3.16±4.35 µIU/ml in patients and 1.15±1.21 µIU/ml in control; and the diffrence was not found as important (p=0.03. IGF-1 level was significantly important in patients with noduler involvement (p=0.015, and GH level was also significantly important in patients with cystic involvement (p=0.05. Conclusion: We supported the hypothesis that GH and IGF-1 levels were important in postadolasence period women patients with acne vulgaris. We recommend new studies comparing GH and IGF-1 levels in adolesence and postadolesence period women patients in order to support the role of these hormones in pathogenesis of acne vulgaris.

  15. Acne Scar Subcision

    OpenAIRE

    B S Chandrashekar; A S Nandini

    2010-01-01

    Subcision is a simple and safe office surgery procedure for treatment of depressed acne scars. It can easily be combined with other treatments such as laser, dermaroller and scar revisions for maximum efficacy.

  16. Bacteriophages Infecting Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    Holger Brüggemann

    2013-01-01

    Full Text Available Viruses specifically infecting bacteria, or bacteriophages, are the most common biological entity in the biosphere. As such, they greatly influence bacteria, both in terms of enhancing their virulence and in terms of killing them. Since the first identification of bacteriophages in the beginning of the 20th century, researchers have been fascinated by these microorganisms and their ability to eradicate bacteria. In this review, we will cover the history of the Propionibacterium acnes bacteriophage research and point out how bacteriophage research has been an important part of the research on P. acnes itself. We will further discuss recent findings from phage genome sequencing and the identification of phage sequence signatures in clustered regularly interspaced short palindromic repeats (CRISPRs. Finally, the potential to use P. acnes bacteriophages as a therapeutic strategy to combat P. acnes-associated diseases will be discussed.

  17. Bacteriophages infecting Propionibacterium acnes.

    Science.gov (United States)

    Brüggemann, Holger; Lood, Rolf

    2013-01-01

    Viruses specifically infecting bacteria, or bacteriophages, are the most common biological entity in the biosphere. As such, they greatly influence bacteria, both in terms of enhancing their virulence and in terms of killing them. Since the first identification of bacteriophages in the beginning of the 20th century, researchers have been fascinated by these microorganisms and their ability to eradicate bacteria. In this review, we will cover the history of the Propionibacterium acnes bacteriophage research and point out how bacteriophage research has been an important part of the research on P. acnes itself. We will further discuss recent findings from phage genome sequencing and the identification of phage sequence signatures in clustered regularly interspaced short palindromic repeats (CRISPRs). Finally, the potential to use P. acnes bacteriophages as a therapeutic strategy to combat P. acnes-associated diseases will be discussed.

  18. Acne: Diet and acnegenesis

    OpenAIRE

    F William Danby

    2011-01-01

    Acne is a manifestation of hormonal overstimulation of the pilosebaceous units of genetically susceptible individuals. Endogenous reproductive and growth hormones, exogenous reproductive hormones, insulin and endogenous insulin-like growth hormone-1, sourced from and stimulated by dairy and high glycemic load foods, all appear to contribute to this overstimulation. A postulated molecular mechanism linking food and acne is reported and integrated into the clinical picture.

  19. Acne: Diet and acnegenesis

    Directory of Open Access Journals (Sweden)

    F William Danby

    2011-01-01

    Full Text Available Acne is a manifestation of hormonal overstimulation of the pilosebaceous units of genetically susceptible individuals. Endogenous reproductive and growth hormones, exogenous reproductive hormones, insulin and endogenous insulin-like growth hormone-1, sourced from and stimulated by dairy and high glycemic load foods, all appear to contribute to this overstimulation. A postulated molecular mechanism linking food and acne is reported and integrated into the clinical picture.

  20. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update.

    Science.gov (United States)

    Melnik, Bodo C

    2015-01-01

    Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to Western diet. Three major food classes that promote acne are: 1) hyperglycemic carbohydrates, 2) milk and dairy products, 3) saturated fats including trans-fats and deficient ω-3 polyunsaturated fatty acids (PUFAs). Diet-induced insulin/insulin-like growth factor (IGF-1)-signaling is superimposed on elevated IGF-1 levels during puberty, thereby unmasking the impact of aberrant nutrigenomics on sebaceous gland homeostasis. Western diet provides abundant branched-chain amino acids (BCAAs), glutamine, and palmitic acid. Insulin and IGF-1 suppress the activity of the metabolic transcription factor forkhead box O1 (FoxO1). Insulin, IGF-1, BCAAs, glutamine, and palmitate activate the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1), the key regulator of anabolism and lipogenesis. FoxO1 is a negative coregulator of androgen receptor, peroxisome proliferator-activated receptor-γ (PPARγ), liver X receptor-α, and sterol response element binding protein-1c (SREBP-1c), crucial transcription factors of sebaceous lipogenesis. mTORC1 stimulates the expression of PPARγ and SREBP-1c, promoting sebum production. SREBP-1c upregulates stearoyl-CoA- and Δ6-desaturase, enhancing the proportion of monounsaturated fatty acids in sebum triglycerides. Diet-mediated aberrations in sebum quantity (hyperseborrhea) and composition (dysseborrhea) promote Propionibacterium acnes overgrowth and biofilm formation with overexpression of the virulence factor triglyceride lipase increasing follicular levels of free palmitate and oleate. Free palmitate functions as a "danger signal," stimulating toll-like receptor-2-mediated inflammasome activation with interleukin-1β release, Th17 differentiation, and interleukin-17-mediated keratinocyte proliferation. Oleate stimulates P. acnes adhesion, keratinocyte proliferation, and comedogenesis via interleukin-1α release. Thus, diet

  1. Acne and diet.

    Science.gov (United States)

    Wolf, Ronni; Matz, Hagit; Orion, Edith

    2004-01-01

    Forbidden foods? "The first law of dietetics seems to be: If it tastes good, it's bad for you" (Isaac Asimov, Russian-born biochemist and science fiction writer). This was essentially the Magna Carta for dermatologists of the 1950s: anything coveted by the teenage palate was suspect for morning after acne. Today, half a century later, although the slant has shifted away for this line of thinking in our dermatologic textbooks, several articles on the beliefs and perceptions of acne patients showed that nothing much has changed and that they expect us to give them detailed instructions of what "acne-related" foods they should avoid. In one such study(1), diet was the third most frequently implicated factor (after hormones and genetics) as the cause of the disease, with 32% of the respondents selecting diet as the main cause, and 44% thinking that foods aggravate acne. In another study that analyzed knowledge about causes of acne among English teenagers, 11% of the responders blamed greasy food as the main cause of the disease(2), whereas in another study found that 41% of final-year medical students of the University of Melbourne chose diet as an important factor of acne exacerbation on a final examination.(3)

  2. Treatment Modalities for Acne.

    Science.gov (United States)

    Fox, Lizelle; Csongradi, Candice; Aucamp, Marique; du Plessis, Jeanetta; Gerber, Minja

    2016-01-01

    Acne is a common inflammatory skin disease which affects the pilosebaceous units of the skin. It can have severe psychological effects and can leave the patient with severe skin scarring. There are four well-recognized pathological factors responsible for acne which is also the target for acne therapy. In this review, different treatment options are discussed, including topical (i.e., retinoids, and antibiotics) and systemic (i.e., retinoids, antibiotics, and hormonal) treatments. Since the general public has been showing an increasing interest in more natural and generally safer treatment options, the use of complementary and alternative medicines (CAM) for treating acne was also discussed. The use of physical therapies such as comedone extraction, cryoslush therapy, cryotherapy, electrocauterization, intralesional corticosteroids and optical treatments are also mentioned. Acne has been extensively researched with regards to the disease mechanism as well as treatment options. However, due to the increasing resistance of Propionibacterium acnes towards the available antibiotics, there is a need for new treatment methods. Additionally, the lack of necessary evidence on the efficacy of CAM therapies makes it necessary for researchers to investigate these treatment options further. PMID:27529209

  3. What's new in acne? An analysis of systematic reviews published in 2011-2012.

    Science.gov (United States)

    Bhate, K; Williams, H C

    2014-04-01

    This review summarizes important clinical developments in acne vulgaris identified from 17 systematic reviews published between February 2011 and August 2012. Regarding causes, Demodex mites have been shown to be associated with both acne vulgaris and rosacea, although it is unclear if their eradication improves either disease. Some weak evidence has emerged that suggests a possible link between dairy produce and acne, which warrants further research. With reference to the effects of acne, there is good evidence that acne negatively affects quality of life, self-esteem and mood in adolescents. Acne is also associated with an increased risk of anxiety, depression and suicidal ideation, highlighting the importance of asking patients with acne directly about psychological issues in order to identify those who might benefit from early psychiatric support. Regarding treatment, there seems to be no additional benefit to using higher strengths of benzoyl peroxide, and lower strengths such as 2.5% have fewer side effects. Despite earlier concerns of increased mortality in those using topical tretinoin for skin cancer prevention, a systematic review on this topic has not found any convincing evidence of a link between such non-cutaneous events and once-daily application of 0.02-0.05% tretinoin. Combined oral contraceptives are of benefit in both inflammatory and non-inflammatory acne. Current surveys suggest that implementation of the pregnancy prevention programme for isotretinoin may not be stringent, and a high level of monitoring and audit is recommended. Ablative and non-ablative laser resurfacing for the treatment of acne scars may be beneficial, but further studies with a longer follow-up period are required.

  4. What's new in acne? An analysis of systematic reviews published in 2011-2012.

    Science.gov (United States)

    Bhate, K; Williams, H C

    2014-04-01

    This review summarizes important clinical developments in acne vulgaris identified from 17 systematic reviews published between February 2011 and August 2012. Regarding causes, Demodex mites have been shown to be associated with both acne vulgaris and rosacea, although it is unclear if their eradication improves either disease. Some weak evidence has emerged that suggests a possible link between dairy produce and acne, which warrants further research. With reference to the effects of acne, there is good evidence that acne negatively affects quality of life, self-esteem and mood in adolescents. Acne is also associated with an increased risk of anxiety, depression and suicidal ideation, highlighting the importance of asking patients with acne directly about psychological issues in order to identify those who might benefit from early psychiatric support. Regarding treatment, there seems to be no additional benefit to using higher strengths of benzoyl peroxide, and lower strengths such as 2.5% have fewer side effects. Despite earlier concerns of increased mortality in those using topical tretinoin for skin cancer prevention, a systematic review on this topic has not found any convincing evidence of a link between such non-cutaneous events and once-daily application of 0.02-0.05% tretinoin. Combined oral contraceptives are of benefit in both inflammatory and non-inflammatory acne. Current surveys suggest that implementation of the pregnancy prevention programme for isotretinoin may not be stringent, and a high level of monitoring and audit is recommended. Ablative and non-ablative laser resurfacing for the treatment of acne scars may be beneficial, but further studies with a longer follow-up period are required. PMID:24635060

  5. Blue and red light acne in acne therapy

    OpenAIRE

    Utz S.R.; Galkina Е.М.; Raigorodskiy Y.M.

    2013-01-01

    The review presents the results of the research of acne phototherapy. The foundational photobiological principles of acne therapy are considered, biomedical and therapeutic values of different wave lengths are discussed, a clinical case of laser technologies use is presented.

  6. The impact of post-acne scars on the quality of life among young adults in Singapore

    Directory of Open Access Journals (Sweden)

    Sai Yee Chuah

    2015-01-01

    Full Text Available Background and Objectives: Post-acne scarring is a common and well-known sequelae of acne vulgaris. We aim to study the impact of post-acne scarring on the quality of life (QOL among young adults in Singapore. Settings and Design: This was a non-interventional prospective study. Materials and Methods: Patients aged 21-40 years with atrophic and hypertrophic acne scars who attended the National Skin Centre, Singapore were recruited in the study. They answered a simple questionnaire and the clinical severity of their acne scars were assessed by the doctor. Statistical Analysis Used: Descriptive analyses using absolute and percentage frequencies were performed on all data. The test of significance was two-sided and was set at 5% (P ≤ 0.05. Differential analyses were conducted using the parametric, independent two-sample t-test and non-parametric Mann-Whitney U-test. The statistical assessments were performed using SPSS version 18.0. Results: A total of 100 patients were studied. The mean patients′ subjective self-scoring on the severity of their post-acne scars was 5.78/10 and the mean Dermatology Life Quality Index (DLQI for post-acne scars was 5.61. Many (36%, n = 36 were self-conscious of their acne scars and 24%, (n = 24 felt that their acne scars was affecting their social activities. Conclusions: Our study showed that post-acne scars have a significant negative effect on the QOL of young adults. It highlights the need to increase public awareness of acne vulgaris and its sequelae through education programs and advocating early treatment to reduce the risk of scarring.

  7. Avaliação dos efeitos adversos clínicos e alterações laboratoriais em pacientes com acne vulgar tratados com isotretinoína oral Evaluation of clinical adverse effects and laboratory alterations in patients with acne vulgaris treated with oral isotretinoin

    Directory of Open Access Journals (Sweden)

    Maria de Fátima de Medeiros Brito

    2010-06-01

    Full Text Available FUNDAMENTOS: A isotretinoína oral revolucionou o manejo da acne. Os efeitos adversos observados, durante o tratamento, são divididos em dois grupos: mucocutâneos e sistêmicos. Anormalidades laboratoriais, principalmente, as dislipidemias e aumento das enzimas hepáticas são relatados. OBJETIVO: Avaliar a tolerabilidade da isotretinoína oral, com atenção, no metabolismo lipídico, função hepática e reações adversas clínicas. MÉTODOS: Foram incluídos 150 pacientes com diagnóstico clínico de acne submetidos a tratamento com isotretinoína oral. Avaliações clínicas e laboratoriais foram feitas, após um mês e a cada três meses, até completar o tratamento. RESULTADOS: Dos 150 pacientes 48% eram do sexo feminino e 52% do sexo masculino. A idade variou de 15 a 32 anos. Quanto aos efeitos adversos cutâneos e mucosos da isotretinoína, queilite foi o mais frequente, ocorrendo em 94% pacientes. Efeitos clínicos sistêmicos foram bem menos comuns. Os níveis de colesterol, triglicerídeos, transaminases, foram avaliados e não mostraram alterações significativas, ao longo do tratamento. CONCLUSÃO: Os pacientes apresentaram efeitos adversos, compatíveis com os da literatura, e, em sua maioria, controlados com medicações sintomáticas. Podemos concluir que a isotretinoína é uma droga segura, em relação a seus efeitos adversos, tanto clínicos como laboratoriais.BACKGROUND: Oral isotretinoin therapy has completely changed the treatment of acne. The clinical adverse effects of isotretinoin are classified into two groups: mucocutaneous and systemic toxic. Laboratory alterations such as dyslipidemia and increase of hepatic enzymes are reported. OBJECTIVES: To evaluate the tolerability of oral isotretinoin with special attention to lipid metabolism, hepatic function, and clinical adverse reactions. METHODS: 150 patients clinically diagnosed with acne being treated with oral isotretinoin were included in the study. Clinical and

  8. Depositing α-mangostin nanoparticles to sebaceous gland area for acne treatment.

    Science.gov (United States)

    Pan-In, Porntip; Wongsomboon, Atthakorn; Kokpol, Chayada; Chaichanawongsaroj, Nuntaree; Wanichwecharungruang, Supason

    2015-12-01

    Although entrapment of nanoparticles of appropriate sizes at hair follicles has been clarified, there is no report on specific clinical application of this finding. Since sebaceous gland is associated with hair follicle, we hypothesize that effective acne vulgaris treatment/prevention can be achieved by depositing anti-acne agent in nanoparticle form at the hair follicles. Challenge of this strategy, however, lies at the finding of effective anti-acne particles with minimal skin irritation. Here using cellulose-based nanoparticles as nano-reservoir and α-mangostin (an active component isolated from the edible Garcinia mangostana Linn. fruit) as anti-acne agent, we prepare nanoparticles highly loaded with α-mangostin. Ability of the obtained particles to sustained release α-mangostin into synthetic sebum is demonstrated. The obtained mangostin particles are verified for their insignificant skin irritation through the two-week, twice-daily open application test in 20 healthy human volunteers. Excellent entrapment and sustainment of the mangostin nanoparticles at the hair follicles are elucidated in six human volunteers by detecting the presence of α-mangostin at the roots of hairs pulled from the treated skin area. The 4-week-randomized, double-blind, placebo-controlled, split-face study in 10 acne patients indicates significant improvement in acne vulgaris condition on the side twice daily applied with mangostin nanoparticles. PMID:26701606

  9. Matrix Metalloproteinases of Epithelial Origin in Facial Sebum of Patients with Acne and their Regulation by Isotretinoin

    OpenAIRE

    Papakonstantinou, E; Aletras, A.; Glass, E; Tsogas, P.; Dionyssopoulos, A.; Adjaye, J.; Fimmel, S.; Gouvousis, P.; Herwig, R.; Lehrach, H; ZOUBOULIS, C.; Karakiulakis, G.

    2005-01-01

    Acne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Matrix metalloproteinases (MMP) have a predominant role in inflammatory matrix remodeling and hyperproliferative skin disorders. We investigated the expression of MMP and tissue inhibitors of MMP (TIMP) in facial sebum specimens from acne patients, before and after treatment with isotretinoin. Gelatin zymography and Western-blot analysis revealed that sebum contains proM...

  10. 红蓝光照射联合中药面膜维持治疗寻常性痤疮疗效观察%Efficacy and safety of blue and red LED phototherapy with Traditional Chinese Medicine mask in the maintenance treatment of acne vulgaris

    Institute of Scientific and Technical Information of China (English)

    高洁; 周李燕; 李超

    2012-01-01

    Objective To observe the effect and safety of maintenance treatment of acne vulgaris by using blue and red light emitting diode (LED) phototherapy combined with Traditional Chinese Medicine (TCM) mask. Methods After being treated with blue and red LED phototherapy with TCM mask for 8 times, 60 patients, who had got successfully improvement (more than 25%), were randomly divided into two groups. 30 patients in experimental group were treated with blue and red LED phototherapy with TCM mask once a week, while another 30 patients in control group were treated with adapalene gel every night. Results The assessment was evaluated alter a course of 16-week treatment. The total number of lesions was significantly decreased after maintenance treatment in both groups. In experimental group and control group, the reduction rate of total lesion counts were 64.20% and 64.69%, respectively, and the relapse rate was 6.67% and 7.14%, with no statistical significant difference between them (P>0.05). In experimental group, the rate of adverse reaction was obviously lower than that of control group (P<0.05). Conclusions The maintenance treatment with blue and red LED phototherapy with TCM mask once a week is effective for mild to moderate acne vulgaris, and its remarkable effect on decreasing relapse rate was similar to adapalene gel, and with few adverse reactions.%目的:观察红蓝光照射联合中药面膜维持治疗对预防和减少寻常性痤疮复发的疗效和安全性.方法:选择60例经红蓝光照射联合中药面膜治疗8次,并获临床有效(改善≥25%)的患者进行随机分组,治疗组30例,给予红蓝光照射联合中药面膜治疗,每周1次;对照组30例,采用每晚1次外用0.1%阿达帕林凝胶.结果:维持治疗16周后评价疗效,两组皮损总数均显著减少,治疗组皮损数减少了64.20%,对照组为64.69%;治疗组复发率为6.67%,对照组为7.14%,两组间比较差异无统计学意义(P>0.05).治疗组皮

  11. Acne Excoriée

    Science.gov (United States)

    ... rash and rashes clinical tools newsletter | contact Share | Acne Excoriée Teen information A A A Scars displayed as dark spots (hyperpigmentation) with virtually no active acne on chest are a sign that the patient ...

  12. Topical Acne Treatments and Pregnancy

    Science.gov (United States)

    Topical Acne Treatments and Pregnancy In every pregnancy, a woman starts out with a 3-5% chance of having ... This sheet talks about whether exposure to topical acne treatments may increase the risk for birth defects ...

  13. Acne neonatorum and familial hyperandrogenism.

    Science.gov (United States)

    Bekaert, C; Song, M; Delvigne, A

    1998-01-01

    We report a case of acne neonatorum developed in a boy since birth. His mother and his aunt had different signs of hyperandrogenism including acne and hirsutism. This case illustrates the correlation between acne neonatorum and familial hyperandrogenism. It shows the importance of the family history and the eventual clinical and serological presence of hyperandrogenism in the mother when confronted with acne neonatorum. PMID:9669129

  14. Serum levels of hypersensitive-C-reactive protein in moderate and severe acne

    Directory of Open Access Journals (Sweden)

    M R Namazi

    2015-01-01

    Full Text Available Background: Elevation of C-reactive protein (CRP has been reported to occur in psoriasis, urticaria, acne, rosacea and many other dermatological and nondermatological conditions. Chronic systemic inflammation has been implicated in the development of neuropsychiatric/degenerative disorders, atherosclerosis, coronary artery disease, diabetes mellitus and even carcinogenesis. The present study is designed to determine whether the level of inflammation created by acne vulgaris could be high enough to raise the serum levels of high-sensitive CRP. Materials and Methods: Forty-two patients with moderate and severe acne vulgaris were enrolled, along with 44 age and sex matched healthy blood donors as controls. Hypersensitive-CRP (Hs-CRP was measured in both groups. Results: Hypersensitive-C-reactive protein levels in the case group varied between 0 and 28.1 μg/ml with an average of 2.24 ± 4.87 μg/ml (mean ± standard deviation and a median of 0.6 μg/ml (interquartile range [IQR] =0.3, 1.4 μg/ml. Hs-CRP levels of the control group varied between 0 and 14 μg/ml with an average of 3.12 ± 3.67 μg/ml and a median of 1.5 μg/ml (IQR = 0.55, 5.0 μg/ml. No significant difference of Hs-CRP level between the two groups was seen (t = -0.961, 95% confidence interval: Lower = -2.6942, upper = 0.9377; P = 0.339. Additionally, no significant difference in the level of Hs-CRP was noted between the moderate and severe acne groups (95% confidence interval: Lower = -5.2495, upper = 1.6711; P = 0.165. Conclusion: Acne vulgaris, even in its severe grades (excluding acne fulminans and acne conglobata, does not induce significant inflammation at the systemic level.

  15. Efficacy and Tolerability of a Three-Step Acne System Containing a Solubilized Benzoyl Peroxide Lotion versus a Benzoyl Peroxide/Clindamycin Combination Product: An Investigator-Blind, Randomized, Parallel-Group Study

    OpenAIRE

    Green, Lawrence J.; Del Rosso, James Q.

    2008-01-01

    A brand three-step acne treatment system containing a solubilized 5% benzoyl lotion and a designated cleanser and moisturizer was compared with a brand benzoyl peroxide 5%/clindamycin 1% gel in subjects with acne vulgaris. The single-center, four-week study was investigator-blinded and randomized. The three-step acne treatment system proved to be comparable in efficacy and tolerability.

  16. Inflammatory Acne Treatment: Review of Current and New Topical Therapeutic Options.

    Science.gov (United States)

    Zeichner, Joshua A

    2016-01-01

    Acne vulgaris (AV) is an inflammatory skin disease characterized by the presence of comedones, papules, pustules, and nodules. Consensus guidelines recommend the use of combination therapy using different drugs with complementary mechanisms of action to best address as many acne pathogenic factors as possible at the same time. Topical acne medications exist as individual agents that may be combined in physician-recommended regimens or as pre-formulated fixed-dose combination products. In addition, there are several new and promising topical therapies currently being developed that work by different mechanisms of action from traditionally used acne therapies. The following review will cover commonly used drugs, newcomers to the market, and what the future holds for the topical treatment of AV. PMID:26741391

  17. Contact dermatitis to topical acne drugs: a review of the literature.

    Science.gov (United States)

    Foti, Caterina; Romita, Paolo; Borghi, Alessandro; Angelini, Gianni; Bonamonte, Domenico; Corazza, Monica

    2015-01-01

    Acne vulgaris is a chronic dermatological disorder that affects the majority of teenagers in the Western world. Topical therapy is widely used to treat mild-moderate acne and is known as well-tolerated thanks to its low systemic toxicity, although associated to skin adverse effects. Acne seems to be associated also to an intrinsic alteration of the epidermal barrier, regarding both the upper and the follicular stratum corneum that promotes the onset of such local side effects. The commonest one is irritant contact dermatitis, an event of frequent observation occurring with erythema, burning, dryness, scaling, and itching, usually characterized by low severity and limited duration. Among topical acne drugs, retinoids are the most irritating ones. Another side effect is allergic contact dermatitis: it is rare and mainly associated to benzoyl peroxide. PMID:26302055

  18. Successful management of acne fulminans with combination of minocycline and dapsone

    Directory of Open Access Journals (Sweden)

    Mendiratta Vibhu

    2006-01-01

    Full Text Available Acne fulminans is a rare and unique variant of acne vulgaris and is characterized by a sudden, violent onset of tender, nodulo-cystic and ulcerocrusted lesions over the back and chest, with fever, arthralgia and weight loss, affecting predominantly adolescent males. The exact etiopathogenesis is unknown although a hypersensitivity reaction is the most accepted hypothesis. Systemic steroids alone or in combination with isotretinoin are the cornerstones of its treatment. The successful management of Acne fulminans in an Indian boy with a combination of minocycline (200 mg once a day and dapsone (200 mg once a day daily is reported. The efficacy of minocycline as an alternative to steroids in the management of acne fulminans is highlighted.

  19. Inflammatory Acne Treatment: Review of Current and New Topical Therapeutic Options.

    Science.gov (United States)

    Zeichner, Joshua A

    2016-01-01

    Acne vulgaris (AV) is an inflammatory skin disease characterized by the presence of comedones, papules, pustules, and nodules. Consensus guidelines recommend the use of combination therapy using different drugs with complementary mechanisms of action to best address as many acne pathogenic factors as possible at the same time. Topical acne medications exist as individual agents that may be combined in physician-recommended regimens or as pre-formulated fixed-dose combination products. In addition, there are several new and promising topical therapies currently being developed that work by different mechanisms of action from traditionally used acne therapies. The following review will cover commonly used drugs, newcomers to the market, and what the future holds for the topical treatment of AV.

  20. Injectable Poly-l-Lactic Acid: A Novel Sculpting Agent for the Treatment of Dermal Fat Atrophy After Severe Acne

    OpenAIRE

    Sadove, Richard

    2008-01-01

    Acne vulgaris affects up to 80% of people 11 to 30 years of age, and scarring can occur for up to 95% of these patients. Scarring may be pitted or hypertrophic in nature, although in most cases it is atrophic. Atrophic acne scarring follows dermal collagen and fat loss after moderate to severe acne infection. Injectable poly-L-acid (PLLA) is a biocompatible, biodegradable, synthetic polymer device that is hypothesized to enhance dermal volume via the endogenous production of fibroblasts and, ...

  1. Moderate acne as a potential barrier to social relationships: myth or reality?

    Science.gov (United States)

    Timms, Richard M

    2013-01-01

    Acne vulgaris is a skin disease affecting many young people and, if it continues into their twenties, can be a substantial barrier to social relationships. Although there is evidence that sufferers are adversely psychologically affected, what is less apparent from research to date is whether this is because of negative self-beliefs or the discriminatory attitudes of others. This study set out to explore how far young people with moderate acne are viewed less favourably compared to their clear-skinned peers. The design was quasi-experimental. The faces of two male and two female 21-year-old volunteers with clear skin were photographed and then photographed again after having had facial signs of moderate acne simulated by a professional make-up artist. Photographs of a male and female face were given to 143 participants who were divided randomly into two conditions: "Clear" and "acne". The former were shown the unblemished faces and the latter were given the faces with acne. The participants were asked to estimate the age of the person in the photograph and then rate the volunteer on a scale of 16 personality items. It was found that the participants in the "clear" condition estimated the volunteers as two years older and more mature than in the "acne" condition. In terms of personality, the photographs in the "clear" condition were given higher scores for potential friendship, attractiveness and overall positive personality features than the photographs in the "acne" condition. The conclusion is that moderate acne vulgaris could be a potential barrier to social relationships for young people not simply because of their social anxiety but because they may well be meeting with prejudice. It is suggested that attitudes might be changed by more accurate information about the condition. PMID:23083139

  2. Evaluation of Acne Quality of Life and Clinical Severity in Acne Female Adults

    OpenAIRE

    Amal Kokandi

    2010-01-01

    Acne is a common disease especially among teenagers. It has a considerable psychological impact on affected individuals. The aim of this paper was to assess if the effect of acne on acne-related quality of life is correlated to acne clinical severity. 112 university female students attending the university medical clinics with acne complaints were examined. Cardiff Acne Disability Index (CADI) was used to assess acne-related quality of life, and global acne grading system (GAGS) was used to a...

  3. Perbandingan Konsumsi Lemak Berdasarkan Tingkat Keparahan Akne Vulgaris pada Siswa SMK Negeri 1 Kota Jambi

    Directory of Open Access Journals (Sweden)

    Nisa Sulistia

    2015-09-01

    Full Text Available Abstrak Salah satu faktor pencetus akne vulgaris adalah diet tinggi lemak, terutama lemak jenuh. Tujuan penelitian ini adalah untuk mengetahui perbandingan konsumsi lemak berdasarkan tingkat keparahan akne vulgaris menurut kriteria Lehmann. Penelitian ini berupa studi analitik observasional dengan desain cross sectional melalui pemeriksaan statusdermatologikus menurut kriteria Lehmann dan pengambilan data konsumsi menggunakan FFQ (Food Frequency Questionnaire pada 138 siswa kelas X dan XI SMK Negeri 1 Kota Jambi. Hasil penelitian menunjukkan terdapat akne vulgaris derajat ringan (49%, akne vulgaris derajat sedang (42%, dan akne vulgaris derajat berat (9%. Reratakonsumsi lemak total 89,35 ± 17,63 gram. Rerata konsumsi SFA (Saturated Fatty Acid 37,07 ± 9,97 gram. Rerata konsumsi MUFA (Monounsaturated Fatty Acid 15,30 ± 11,79 gram. Rerata konsumsi PUFA (Polyunsaturated Fatty Acid 12,03 ± 9,25 gram.Uji oneway Anova menunjukkan tidak ada perbedaan bermakna rerata konsumsi lemak total (p > 0,05 dan SFA (p > 0,05 berdasarkan tingkat keparahan akne vulgaris. Uji Kruskal-Wallis menunjukkan tidak ada perbedaan bermakna MUFA (p > 0,05, dan PUFA (p > 0,05 berdasarkan tingkat keparahan akne vulgaris. Penelitian ini menunjukkan tidak ada perbedaan konsumsi lemak berdasarkan tingkat keparahan akne vulgaris pada siswa SMKNegeri 1 Kota Jambi.Kata kunci: akne vulgaris, FFQ, lemak total, SFA, MUFA, PUFA Abstract One of the precipited factors is high fat diet, especially saturated fats. The objective of this study was to determine the comparison of fat consumption which is based on the severity of acne vulgaris.This research wasanalytic observational study using cross sectional design, by examining dermatologic status according to Lehmann criteria and  taking consumption record with FFQ (Food Frequency Questionnaire of  138 tenth and eleventh grade student in SMKN 1 Jambi. The result showed that mild acne vulgaris (49%, moderate acne vulgaris (42%, and

  4. Acne - self-care

    Science.gov (United States)

    ... It may help to use a wash with salicylic acid or benzoyl if your skin is oily and prone to acne. Remove all ... products may contain benzoyl peroxide, sulfur, resorcinol, or ... bacteria, drying up skin oils, or causing the top layer of your ...

  5. Ichthyosis vulgaris

    DEFF Research Database (Denmark)

    Thyssen, J P; Godoy-Gijon, E; Elias, P M

    2013-01-01

    Ichthyosis vulgaris is caused by loss-of-function mutations in the filaggrin gene (FLG) and is characterized clinically by xerosis, scaling, keratosis pilaris, palmar and plantar hyperlinearity, and a strong association with atopic disorders. According to the published studies presented...... in this review article, FLG mutations are observed in approximately 7·7% of Europeans and 3·0% of Asians, but appear to be infrequent in darker-skinned populations. This clinical review article provides an overview of ichthyosis vulgaris epidemiology, related disorders and pathomechanisms. Not only does...... ichthyosis vulgaris possess a wide clinical spectrum, recent studies suggest that carriers of FLG mutations may have a generally altered risk of developing common diseases, even beyond atopic disorders. Mechanistic studies have shown increased penetration of allergens and chemicals in filaggrin...

  6. Complete Genome Sequence of Propionibacterium acnesType IB Strain 6609▿

    OpenAIRE

    Hunyadkürti, Judit; Feltóti, Zsófia; Horváth, Balázs; Nagymihály, Marianna; Vörös, Andrea; McDowell, Andrew; Patrick, Sheila; Urbán, Edit; Nagy, István

    2011-01-01

    Propionibacterium acnesis an anaerobic Gram-positive bacterium that forms part of the normal human cutaneous microbiota and is thought to play a central role in acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit (I. Kurokawa et al., Exp. Dermatol. 18:821-832, 2009). Here we present the whole genome sequence of P. acnestype IB strain 6609, which was recovered from a skin sample from a woman with no recorded acne history and is thus considered a nonpathogenic strain (I. Nag...

  7. Preliminary Observation of Face-mouth Infrared Thermal Image with Single Acupuncturing on Hegu (LI4) for Patients with Acne Vulgaris%单次针刺合谷穴对寻常型痤疮患者面口部红外热像图影响的观察

    Institute of Scientific and Technical Information of China (English)

    杨素音; 许金森; 潘晓华; 兰彩莲

    2015-01-01

    目的:观察单次针刺合谷穴对寻常型痤疮患者面部红外热像图及皮肤温度的影响。方法:应用红外热像仪对50例寻常型痤疮患者分为合谷组和外关组进行红外热像图扫描,观察其面部针刺前后红外热图像和温度的变化。结果:合谷组单次针刺后的面部最高温、最低温及平均温度较针刺前有明显的升高,且温度的差值具有统计学意义(P<0.05),而外关组温度的变化不具有统计学意义。结论:单次针刺合谷穴可引起面部皮肤温度的上升,使面部血管扩张、改善血液循环,促进皮肤细胞的新陈代谢。%Objective:To observe the influences of single acupuncturing of Hegu (LI4) on facial thermal images and facial temperature.Methods:The 50 patients with acne vulgaris were divided into Hegu group and Waiguan group and the facial temperature and infrared thermal images were observed before and after accepting a single acupuncturing respectively.Results:Hegu group’s facial maximum temperature,minimum temperature and average temperature after single acupuncturing is significantly higher than that before the treatment,and the temperature difference was statistically significant (P0.05).Conclusion:Single acupuncturing on Hegu can cause facial temperature rising,which dilates capillary vessels, improves blood circulation and promotes metabolism of skin cells.

  8. Improving adherence to acne treatment: the emerging role of application software

    Directory of Open Access Journals (Sweden)

    Park C

    2014-02-01

    Full Text Available Chanhyun Park,1 Gilwan Kim,1 Isha Patel,2 Jongwha Chang,3 Xi Tan2 1College of Pharmacy, University of Texas at Austin, Austin, TX, USA; 2College of Pharmacy, University of Michigan, Ann Arbor, MI, USA; 3McWhorter School of Pharmacy, Samford University, Birmingham, AL, USA Objective: To examine recent studies on the effect of mobile and electronic (ME-health technology on adherence to acne treatment. Background: With emerging use of ME-health technology, there is a growing interest in evaluating the effectiveness of the tools on medication adherence. Examples of ME-health technology-based tools include text message-based pill reminders and Web-based patient education. Methods: MEDLINE, Cochrane Library, and Web of Science were searched for articles on adherence to acne treatment published through November 2013. A combination of search terms such as "acne" and "adherence" or "compliance" were used. Results: Adherence to oral acne medication was higher than for topical acne medication. The frequency of office visits was also an influencing factor for acne treatment adherence. The telephone-based reminders on a daily basis did not improve acne patients' medication adherence, whereas the Web-based educational tools on a weekly basis had a positive effect on medication adherence in acne treatment. Conclusion: In using ME-health interventions, factors such as medication dosage forms, frequency of intervention, and patients' preferences should be taken into consideration. Developing disease-specific text message reminders may be helpful to increase adherence rates. In addition, a combination of text message reminders with another type of intervention may improve medication adherence. Keywords: acne vulgaris, medication adherence, compliance, mobile and electronic health technology, application software, telemedicine

  9. Isotretinoin Use in Severe Acne

    OpenAIRE

    Turgeon, E.W.T.

    1985-01-01

    Isotretinoin, an oral vitamin A derivative, is highly effective in, and at present indicated only for, the treatment of cystic acne, conglobate acne, or severe acne which has failed to respond to conventional therapy, including systemic antibiotics. Isotretinoin use usually results in a prolonged remission, often with complete disappearance of previously resistant lesions. Virtually all patients experience reversible integumentary side effects, which can almost always be controlled with emoll...

  10. Status report from the American Acne & Rosacea Society on medical management of acne in adult women, part 3: oral therapies.

    Science.gov (United States)

    Del Rosso, James Q; Harper, Julie C; Graber, Emmy M; Thiboutot, Diane; Silverberg, Nanette B; Eichenfield, Lawrence F

    2015-12-01

    Parts 1 and 2 of this 3-part series provided an overview of the epidemiology, visible patterns, and important considerations for clinical and laboratory evaluation of acne vulgaris (AV) in adult women and reviewed the role of proper skin care and topical therapies in this patient population. In Part 3, oral therapies including combination oral contraceptives, spironolactone, antibiotics, and isotretinoin are discussed along with important considerations that clinicians should keep in mind when selecting oral agents for management of AV in adult women. PMID:26761932

  11. Dietary intervention in acne

    OpenAIRE

    Melnik, Bodo

    2012-01-01

    The purpose of this paper is to highlight the endocrine signaling of Western diet, a fundamental environmental factor involved in the pathogenesis of epidemic acne. Western nutrition is characterized by high calorie uptake, high glycemic load, high fat and meat intake, as well as increased consumption of insulin- and IGF-1-level elevating dairy proteins. Metabolic signals of Western diet are sensed by the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), which integ...

  12. [Acne and diet].

    Science.gov (United States)

    Melnik, B C

    2013-04-01

    In industrialized countries acne presents as an epidemic disease of civilization affecting sebaceous follicles of adolescents and young adults, associated with increased body mass index and insulin resistance. "Western style" diet, characterized by high glycaemic load and increased consumption of insulinotropic milk proteins, plays an important role in acne pathogenesis. On the cellular level, nutrient-derived metabolic signals are sensed by the metabolic transcription factor FoxO1 and integrated by the regulatory kinase mTORC1. mTORC1, the central hub of protein- and lipid biosynthesis, cell growth and proliferation, is activated by insulin, IGF-1 and branched-chain essential amino acids, especially leucine. The understanding of Western diet-mediated nutrient signalling with over-activated mTORC1 offers a reasonable approach for dietary intervention in acne by lowering glycaemic load and consumption of milk and milk products. A suitable diet attenuating increased mTORC1 activity is a Palaeolithic-like diet with reduced intake of sugar, hyperglycaemic grains, milk and milk products but enriched consumption of vegetables and fish. PMID:23529682

  13. Blue and red light acne in acne therapy

    Directory of Open Access Journals (Sweden)

    Utz S.R.

    2013-09-01

    Full Text Available The review presents the results of the research of acne phototherapy. The foundational photobiological principles of acne therapy are considered, biomedical and therapeutic values of different wave lengths are discussed, a clinical case of laser technologies use is presented.

  14. New Developments in Acne Treatment

    OpenAIRE

    Stolman, Lewis P.

    1982-01-01

    Acne is a metabolic disorder of the pilosebaceous appendage in which microorganisms, hormones, inflammatory cells and fatty acids seem to contribute to the pathologic process. Through education and judicious use of therapeutic agents including benzoyl peroxide, vitamin A acid, topical and systemic antibiotics and 13 cis retinoic acid, most patients with acne can enjoy good control of their disease.

  15. Comparison of pneumatic broadband light plus adapalene gel 0.3% versus adapalene gel 0.3% monotherapy in the treatment of mild to moderate acne.

    Science.gov (United States)

    Tangjaturonrusamee, Chinmanat; Rattanaumpawan, Pinyo; Ditre, Chérie M

    2016-07-01

    Acne vulgaris is a common and distressing condition that typically presents in adolescents and young adults. The aim of this split-face, single-blind, randomized, controlled study was to determine if combination therapy with pneumatic broadband light (PBBL) plus adapalene gel 0.3% is superior to adapalene gel 0.3% monotherapy in the treatment of acne. Results indicated that the addition of PBBL to topical regimens may lead to quicker results and therefore may improve treatment adherence to topical therapies in acne patients. PMID:27529709

  16. Is acne caused by colonization with the "wrong" strain of Propionibacterium acnes? A review of the role of Propionibacterium acnes in acne

    DEFF Research Database (Denmark)

    Lomholt, Hans Bredsted; Kilian, Mogens

    2008-01-01

    Acne is still a major problem, and treatment options are far from ideal. A number of studies suggest that the species Propionibacterium acnes plays an important role in the pathogenesis, and new data point towards molecular mechanisms by which the organism is able to trigger the host inflammatory...... response. The current knowledge on P. acnes in relation to acne is reviewed....

  17. Development of anti-acne gel formulation of anthraquinones rich fraction from Rubia cordifolia (Rubiaceae

    Directory of Open Access Journals (Sweden)

    K Khan

    2012-01-01

    Full Text Available Summary. Acne vulgaris, a common skin disorder speculated in the age group of 15-25 years begins with increased production of sebum followed by the attack of Propionibacterium acne (Kathryn et al. Most of the synthetic anti-acne drugs tend to exhibit mild to severe side effects along with peeling and darkening of skin, ultimately leading to social withdrawal. Hence, there arises a need to develop a safe and effective anti-acne formulation that would cure and also prevent recurrence of acne. Considering the fact that roots of R. cordifolia (Rubiaceae are rich in anthraquinones characterized for their anti-inflammatory as well as wound healing property, (Singh, 2004 a gel formulation of anthraquinone rich fraction was developed and evaluated for its anti-acne potential using Cup plate diffusion method. A gel formulation containing 0.1 % of anthraquinone rich fraction exhibited optimum anti-acne activity against P.acne, S.epidermidis, M.furfur (zone of inhibition- 28.9, 20.4, 24.6 mm respectively when compared with standard i.e. Clindamycin gel (zone of inhibition- 36.7, 35.3, 32.7 mm respectively. Thus anthraquinone rich fraction in a gel formulation is proved to have a better potential in treating acne. Industrial relevance. Rubia cordifolia, often known as Common Madder, Indian Madder or Manjistha is highly recommended in skin diseases associated with edema and oozing (Yuangang Zu et al, 2010. The root powder was found to work well with ghee, for the medicament of acne. Used externally as a paste by itself or with honey, it heals inflammation and gives the skin an even tone and smoothness. Since the roots are claimed to be rich in anthraquinones, in this research work anthraquinone rich fraction from the roots R. cordifolia were extracted and formulated into an herbal gel and evaluated for its anti-acne activity. Topical gels are very useful as palliative products and prove to be economical and safe; hence it was decided to formulate a simple

  18. Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Adalatkhah H

    2011-07-01

    Full Text Available Hassan Adalatkhah1, Farhad Pourfarzi2, Homayoun Sadeghi-Bazargani31Department of Dermatology, 2Department of Social Medicine, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil; 3Statistics and Epidemiology Department, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, IranBackground: The use of oral flutamide is rarely investigated in acne therapy. The aim of this study was to compare the efficacy of oral flutamide with that of a cyproterone-estradiol combination in treating acne lesions.Methods: A randomized clinical trial enrolled patients with moderate acne into two equal groups to receive either oral flutamide or the cyproterone-estradiol combination for 6 months. Lesion count, Acne Severity Index, and Global Acne Grading system (GAGS scores were used to assess improvement in acne lesions. The dichotomous measurement scale for primary endpoint assessment was defined as improvement from moderate to mild acne based on GAGS score. Patient satisfaction and dermal fat were also assessed. Intention to treat and per protocol analyses were done, reporting related effect sizes.Results: Both treatments resulted in substantial improvement in acne lesions. Although flutamide seemed to have higher efficacy, an intention to treat analysis did not find the two treatment protocols to be different. The relative risk in intention to treat analysis was 1.8 (95% confidence interval [CI] 0.89–1.6, and was 1.33 (95% CI 1.03–1.72 for the per protocol analysis. The number needed to treat for flutamide compared with the cyproterone-estradiol combination was 7.7 and 4.2 in the intention to treat and per protocol analyses, respectively.Conclusion: Flutamide appears to be more effective than a cyproterone-estradiol combination in some aspects of acne treatment, but this requires confirmation in a larger trial.Keywords: acne vulgaris, flutamide, cyproterone acetate, ethinyl estradiol, androgen antagonists

  19. Acne Scars: Pathogenesis, Classification and Treatment

    OpenAIRE

    Gabriella Fabbrocini; Annunziata, M. C.; V. D'Arco; V. De Vita; Lodi, G.; M. C. Mauriello; F. Pastore; G. Monfrecola

    2010-01-01

    Acne has a prevalence of over 90% among adolescents and persists into adulthood in approximately 12%–14% of cases with psychological and social implications. Possible outcomes of the inflammatory acne lesions are acne scars which, although they can be treated in a number of ways, may have a negative psychological impact on social life and relationships. The main types of acne scars are atrophic and hypertrophic scars. The pathogenesis of acne scarring is still not fully understood, but severa...

  20. Cardiff Acne Disability Index in Sarawak, Malaysia

    OpenAIRE

    Yap, Felix Boon-Bin

    2012-01-01

    Background Acne is considered a cosmetic nuisance in Malaysia since no insurance coverage is provided for its treatment. Its psychological impact is unknown. Objective The aim of this study is to determine the impact of acne on quality of life and its relationship with severity. Methods A cross-sectional study using the Cardiff acne disability index (CADI) and Global Acne Grading System for acne severity grading was done in three government-run dermatology clinics in Sarawak, Malaysia. Result...

  1. Psychodermatologic Effects of Atopic Dermatitis and Acne: A Review on Self-Esteem and Identity.

    Science.gov (United States)

    Nguyen, Catherine M; Koo, John; Cordoro, Kelly M

    2016-01-01

    Atopic dermatitis (AD) and acne vulgaris are among the most-prevalent skin diseases in children. Both have been well documented in the literature to have significant negative effects on quality of life. Herein, we discuss the results of a comprehensive literature review aimed at assessing the impact of acne and AD on self-esteem and identity. We highlight clinical tools for their assessment and offer coping strategies for patients and families. Multiple factors including relationships with parents and classmates, sports participation, and the sex of the patient contribute to the development of self-esteem and identity in individuals with AD and acne. Atopic dermatitis was found to have significant behavioral effects on children, ultimately resulting in a lack of opportunity to develop proper coping. AD had a more-prominent role in identity formation and gender roles in girls. Acne vulgaris was found to have a more direct effect on self-esteem, self-confidence and identity, especially in girls. The Cutaneous Body Image Scale is reviewed and offered as an easy and reliable tool to evaluate a patient's mental perception of the appearance of their skin. Coping strategies that may be offered to patients and families include empowerment and cognitive adaptation. PMID:27001316

  2. Efficacy of Garcinia mangostana L. (mangosteen rind extract to reduce acne severity

    Directory of Open Access Journals (Sweden)

    Toni Sutono

    2013-08-01

    Full Text Available Background: In vitro studies showed that extract of mangosteen rind (EMR (Garcinia mangostana L. containing xanthones has antibacterial effect against Propionibacterium acnes and also anti-inflammatory effect. The aim of this study is to determine the efficacy of EMR in reducing acne vulgaris (AV.Methods: A randomized, double-blind, placebo controlled clinical trial was done on 94 subjects (18-30 years with mild and moderate AV. The treatment group was given 400 mg EMR 3 times daily orally, for 3 weeks and control group was given placebo capsules. As a standard therapy, all subjects were given a topical cream of 0.025% retinoic acid applied on acne lesions during night time. Efficacy was assessed by counting the acne lesion number as well as proportion of subjects with more than 20% decrease in lesion. The decrease of plasma malondialdehyde (MDA levels were also measured.Results: After 3 weeks of treatment, acne lesion counts was significantly reduced in both groups [from 934 to 584 lesion (37% in treatment group, p < 0.001 and from 832 to 608 lesion (27% in control group, p < 0.001]. Comparison between the two groups revealed a non significant difference (p > 0.55. The proportion of subjects whose acne lesion reduced ≥ 20% was 73% (33 of 45 subjects in treatment group vs 66% (27 of 41 subjects in control (p > 0.2. The level MDA was reduced from 1.16 to 1.02 nmol/mL in treatment group and from 1.32 become 1.02 nmol/mL in control (p > 0.48.Conclusion: Extract of mangosteen rind given orally for 3 weeks clinically reduced acne severity better than placebo, although statistically was not significant. Antioxidant effect of EMR seem to be unspecific in reducing acne severity. (Med J Indones. 2013;22:167-72. doi: 10.13181/mji.v22i3.586 Keywords: Acne vulgaris, malondialdehyde, mangosteen rind extract, retinoid acid

  3. Acne by Mikael Zobel

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    <正>提起Acne,你会立即想到什么?暗疮?不错,这的确是它的英文解释。可是Acne同时也是一个在瑞典家喻户晓的品牌名称,全名是Ambitions to Create Novel Expressions的Acne,是斯德哥尔摩的牛仔裤专家。年前与Lanvin合作的系列曾引起了一阵风潮。喜欢找不同设计师台作的Acne,这次请到的是产品在各国艺术馆展出的德国著名珠宝师Mikael Zobel。Mikael Zobel为Acne设计的09秋冬高级珠宝系列共有20多件,包括了吊坠、胸针、袖口钮和戒指等。设计的特色是原石及经过打磨的矿物的混合材料,如212克拉的红碧玺、紫锂辉石、白及紫玉石、金发石英,以及黑色、粉色、黄色和未经琢磨的钻石原石。所有宝石都根据各自的功能与设计,以经过抛光、氧化、装饰及电镀过的金、白金及银等金属共同镶嵌。虽然所用的材料都罕有而珍贵,但Mikael Zobel的设计却令整个系列不会过于奢华及俗气,反带有低调而贵气的味道。这个简洁而具有雕塑感觉的系列乍看之下有点女性化,但原石及金属的特殊质感,令整个系列仍不失Acne一贯的硬朗。官方网站由即日起接受订购。网址:shop.acnestudios.com

  4. The Clinical FeatUres of Severe Acne Investigation%重型痤疮临床特征分析

    Institute of Scientific and Technical Information of China (English)

    起珏; 吕乐春; 郭美华; 郑琪; 吴文娟; 何黎

    2014-01-01

    Objective To analyze the clinical features of severe acne patients of different genders,ages to provide a basis for more targeted treatments. Methods From 2009 to 2011,by a sampling survey,1 944 severe acne patients from 35 third-class a hospitals in 24 cities and used" Acne Vulgaris Genetic Epidemiology questionnaires". Two experienced dermato-logical clinicians assessed the types,quantity,locations of patientsˊ skin damages and guided them to complete the question-naires. ResUlts In 1 944 severe acne patients,there were 1 000 males,944 females;1 433 had adolescent acnes〔842 males (58. 8%),591 females(41. 2%)〕,591 had adult acne〔158 males(30. 9%),353 females(69. 1%)〕. There was sig-nificant difference in distribution of varying types of acnes between males and females(χ2 =116. 60,P<0. 001). Totally 377 patients had adult persistent acnes lasting from adolescent onset until after the age of 25 ( 73. 5%),134 had late-onset acnes after the age of 25(26. 5%). In 353 females patients with adult acnes,238 had persistent(67. 4%),115 had late-onset (32. 6%). In 158 males with adult acnes,139 had persistent(88. 0%),19 had late-onset(12. 0%). Adult acnes were mainly persistent both in males and females,but the proportion of late-onset acnes was higher in females than in males,the difference was significant〔χ2 =23. 36,OR=2. 71,95%CI(1. 73,4. 23),P<0. 001〕. A total of 716 patients had acne family histories(36. 8%),including 349 males,367 females;569 had adolescent acnes(79. 5%),130 had persistent (18. 1%),17 had late-onset(2. 4%). The proportion of adolescent acnes was the highest in males and females who had acne family histories. The proportion of adolescent acnes was higher in males than in females,while that of persistent,late-onset ac-nes higher in females than in males(P<0. 05). In females severe acne patients,adolescent acne pimples/pustules were more than persistent(Z =2. 39,P =0. 017),similar to late -onset(Z =1. 25,P =0. 210);the atrophic acars were

  5. Preparation, characterization, and in vitro antimicrobial assessment of nanocarrier based formulation of nadifloxacin for acne treatment.

    Science.gov (United States)

    Kumar, A; Agarwal, S P; Ahuja, A; Ali, J; Choudhry, R; Baboota, S

    2011-02-01

    The objective of the present study was to develop a nanocarrier based formulation of nadifloxacin and to investigate its in vitro antimicrobial effect against Propionibacterium acnes. Nanocarrier based microemulsion formulations were prepared by aqueous titration method, using oleic acid as oil phase, Tween-80 as surfactant and ethanol as co-surfactant in different ratios. This procedure yielded monodisperse microemulsions exhibiting a mean droplet size in the range of 95-560 nm. This range of particle size is good to treat follicle related disorders like acne vulgaris because the size of follicles is in the range of 50-100 microm. Furthermore the optimized formulations were characterized for surface morphology by transmission electron microscopy and refractive index. The permeation studies were carried out using rat skin mounted in Franz diffusion cells. Flux of the optimised formulation was 2.24 times that of control. The diameter of inhibition zone of the microemulsion was found good but smaller than that of a clindamycin disc because of the higher therapeutic efficacy of clindamycin against P. acnes. The results indicated that the developed microemulsion shows promising results against P. acnes bacteria and may be a good approach for acne treatment. PMID:21434572

  6. Acne scars in 18-year-old male adolescents: a population-based study of prevalence and associated factors*

    Science.gov (United States)

    Lauermann, Fernanda Tcatch; de Almeida Jr., Hiram Larangeira; Duquia, Rodrigo Pereira; de Souza, Paulo Ricardo Martins; Breunig, Juliano de Avelar

    2016-01-01

    Background Acne vulgaris is a pilosebaceous follicle disorder affecting over 85% of adolescents to some degree. It frequently causes psychological distress that may persist into adulthood due to scarring. Little information about post-acne scarring epidemiology is available. Objectives To describe prevalence, distribution patterns and associated factors of acne scarring in young males, drawing on a representative population sample from a southern Brazilian city. Methods A cross-sectional study was undertaken during presentation for military service, which is compulsory for all 18-year-old males. A questionnaire was applied, covering topics like diet, smoking habits, ethnicity, family structure, socio-economic level, as well as specific questions about active acne and resulting scars. Dermatologists conducted the clinical examination. Results A total of 2,201 male adolescents were interviewed and examined. The overall prevalence of acne scarring was 22%. The malar region was the most frequently involved, present in 80% of affected individuals, followed by the frontal region (31.5%), back (17%), anterior chest (8.2%) and mentonian region (6.4%). Correlation between the intensity of clinical acne and the presence of scars was found, but no association was observed with educational level, smoking, ethnicity, obesity or socio-economic status. Conclusions There is a high prevalence of acne scars among this population. This is the first study to ascertain a correlation between acne scarring and factors such as socio-economic status and educational level. The direct relation between acne severity and scarring indicates that prompt and effective treatment is the best way to reduce scarring.

  7. Acne scars in 18-year-old male adolescents: a population-based study of prevalence and associated factors*

    Science.gov (United States)

    Lauermann, Fernanda Tcatch; de Almeida Jr., Hiram Larangeira; Duquia, Rodrigo Pereira; de Souza, Paulo Ricardo Martins; Breunig, Juliano de Avelar

    2016-01-01

    Background Acne vulgaris is a pilosebaceous follicle disorder affecting over 85% of adolescents to some degree. It frequently causes psychological distress that may persist into adulthood due to scarring. Little information about post-acne scarring epidemiology is available. Objectives To describe prevalence, distribution patterns and associated factors of acne scarring in young males, drawing on a representative population sample from a southern Brazilian city. Methods A cross-sectional study was undertaken during presentation for military service, which is compulsory for all 18-year-old males. A questionnaire was applied, covering topics like diet, smoking habits, ethnicity, family structure, socio-economic level, as well as specific questions about active acne and resulting scars. Dermatologists conducted the clinical examination. Results A total of 2,201 male adolescents were interviewed and examined. The overall prevalence of acne scarring was 22%. The malar region was the most frequently involved, present in 80% of affected individuals, followed by the frontal region (31.5%), back (17%), anterior chest (8.2%) and mentonian region (6.4%). Correlation between the intensity of clinical acne and the presence of scars was found, but no association was observed with educational level, smoking, ethnicity, obesity or socio-economic status. Conclusions There is a high prevalence of acne scars among this population. This is the first study to ascertain a correlation between acne scarring and factors such as socio-economic status and educational level. The direct relation between acne severity and scarring indicates that prompt and effective treatment is the best way to reduce scarring. PMID:27438194

  8. Comparative study of oral isotretinoin versus oral isotretinoin + 20% salicylic acid peel in the treatment of Active Acne

    Directory of Open Access Journals (Sweden)

    Bikash Ranjan Kar

    2013-01-01

    Full Text Available Background: Acne is a self limiting condition that often results in scarring and disfigurement disproportionate to its clinical severity. Isotretinoin is considered the gold standard in the medical management of severe form of acne vulgaris. Salicyclic acid (SA peels, a β- hydroxy acid peel has got sebosuppressive effect and helps in faster resolution of acne with minimal scarring. It also decreases the post inflammatory hyperpigmentation. Combining both the modalities is usually not advocated because of expected excessive dryness and irritation Aims: To compare the efficacy of oral isotretinoin and oral isotretinoin with 20% SA peels in patients with moderate to severe acne. Materials and Methods: 60 consecutive patients with moderate to severe facial acne attending the skin department were randomized in to 2 groups. 1 st group received 20mg oral isotretinoin once daily for 16 weeks and 2nd group received 20mg oral isotretinoin once daily along with 20% SA peels every two weeks for 16 weeks. Baseline grading of acne was done with Michelsons Acne severity index (MASI.Right and left sides of the face were scored separately and total score was taken. Severity score was assessed monthly .Clinical photographs were obtained for evaluation every month. Patients were asked to follow up once every 2 weeks or earlier in case of any adverse events. Results: Patients in both the groups revealed a reduction in the number of lesions. The 1 st group showed a reduction of approximately 73.4% after receiving 20mg oral isotretinoin for 16 weeks. The 2 nd group showed a reduction of approximately 92.5 % after receiving 20mg oral isotretinoin along with 20% SA peel once every 2 weeks for 16 weeks. Conclusion: Both oral isotretinoin and combination of oral isotretinoin with 20% SA peels once every 2 weeks are effective in treating moderate to severe acne but the combination showed significantly better clearance of acne than monotherapy with isotretinoin.

  9. Comparison the effectiveness of pyruvic acid 50% and salicylic acid 30% in the treatment of acne

    Directory of Open Access Journals (Sweden)

    Fariba Jaffary

    2016-01-01

    Full Text Available Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles and one of the most common skin diseases. The peeling method has been recently found to be effective for acne treatment. This study aimed to compare the efficacy of pyruvic acid 50% and salicylic acid 30% peeling in the treatment of mild to moderate acne. Materials and Methods: In a prospective single-blinded clinical trial, 86 patients with acne were randomly assigned into two groups. In both groups, the routine treatment of acne (topical solution of erythromycin 4%, triclorocarban soap, and sunscreen were used twice a day for 8 weeks. In addition, salicylic acid 30% for the control group and pyruvic acid 50% for the case group were used. In both groups, acne severity index (ASI was calculated before and at week 2, 4, 6, and 8 of the treatment. Patient satisfaction was assessed at the end of the treatment. Side effects were recorded using a checklist. Results: In both groups, the reduction in the number of comedones, papules, and ASI were statistically significant (P < 0.001 in the course of treatment. However, it was not significant regarding the number of pustules (P = 0.09. None of the number of comedone, papules, pustules, and ASI was statistically different between study groups. Both treatment groups had similar side effects except for scaling in the fifth session, which was significantly lower in salicylic acid - treated patients (P = 0.015. Conclusion: Both pyruvic acid 50% and salicylic acid 30% are effective in the improvement of mild to moderate acne with no significant difference in efficacy and side effects.

  10. Zolav®: a new antibiotic for the treatment of acne

    Directory of Open Access Journals (Sweden)

    Dinant A

    2016-03-01

    Full Text Available Alexa Dinant,1 Ramiz A Boulos2,3 1AXD Pty Ltd, Semaphore Park, 2School of Chemical and Physical Sciences, Flinders University, Bedford Park, 3Boulos & Cooper Pharmaceuticals Pty Ltd, Port Adelaide, SA, Australia Background: Acne is a prominent skin condition affecting >80% of teenagers and young adults and ~650 million people globally. Isotretinoin, a vitamin A derivative, is currently the standard of care for treatment. However, it has a well-established teratogenic activity, a reason for the development of novel and low-risk treatment options for acne. Objective: To investigate the effectiveness of Zolav®, a novel antibiotic as a treatment for acne vulgaris. Materials and methods: Minimum inhibitory concentration of Zolav® against Propionibacterium acnes was determined by following a standard protocol using Mueller-Hinton broth and serial dilutions in a 96-well plate. Cytotoxicity effects on human umbilical vein endothelial cells and lung cells in the presence of Zolav® were investigated by determining the growth inhibition (GI50 concentration, total growth inhibition concentration, and the lethal concentration of 50% (LC50. The tryptophan auxotrophic mutant of Escherichia coli strain, WP2 uvrA (ATCC 49979, was used for the AMES assay with the addition of Zolav® tested for its ability to reverse the mutation and induce bacterial growth. The in vivo effectiveness of Zolav® was tested in a P. acnes mouse intradermal model where the skin at the infection site was removed, homogenized, and subjected to colony-forming unit (CFU counts. Results: Susceptibility testing of Zolav® against P. acnes showed a minimum inhibitory concentration of 2 µg/mL against three strains with no cytotoxicity and no mutagenicity observed at the highest concentrations tested, 30 µM and 1,500 µg/plate, respectively. The use of Zolav® at a concentration of 50 µg/mL (q8h elicited a two-log difference in CFU/g between the treatment group and the control

  11. Understanding Acne: How to Banish Breakouts

    Science.gov (United States)

    ... equipment, backpacks, tight collars or tight sports uniforms Skin irritants, such as pollution and high humidity Squeezing or picking at blemishes Hard scrubbing of the skin Stress Web Sites Acne What Is Acne? back ...

  12. Acne, cystic on the face (image)

    Science.gov (United States)

    The face is the most common location of acne. Here, there are 4 to 6 millimeter red ( ... scars and fistulous tract formation (connecting passages). Severe acne may have a profound psychological impact and may ...

  13. Fillers for the improvement in acne scars

    Science.gov (United States)

    Wollina, Uwe; Goldman, Alberto

    2015-01-01

    Acne is a common inflammatory disease. Scarring is an unwanted end point of acne. Both atrophic and hypertrophic scar types occur. Soft-tissue augmentation aims to improve atrophic scars. In this review, we will focus on the use of dermal fillers for acne scar improvement. Therefore, various filler types are characterized, and available data on their use in acne scar improvement are analyzed. PMID:26491364

  14. Therapeutic Approach to Acne and Rosacea, Introduction.

    Science.gov (United States)

    Graber, Emmy M

    2016-06-01

    Acne has been written about since ancient Greek times and was a recognized entity even during Cleopatra's reign. Today, acne is pervasive in most cultures and is the number two reason why patients visit a dermatologist in the United States. It is the eighth most common disease worldwide. Despite the longstanding awareness of acne and its prevalence, no perfect treatment yet exists. PMID:27416307

  15. Current and future treatment options for acne.

    NARCIS (Netherlands)

    Kerkhof, P.C.M. van de; Kleinpenning, M.M.; Jong, E.M.G.J. de; Gerritsen, M.J.P.; Dooren-Greebe, R.J. van; Alkemade, J.A.C.

    2006-01-01

    Acne is a frequent skin disease with abnormalities in the process of keratinization, sebaceous gland functioning and inflammation. In this review, our understanding of the pathogenesis of acne has been updated. An overview of efficacy and side effects of available anti-acne treatments is presented.

  16. Chemical peels for acne and acne scars in asians: Evidence based review

    Directory of Open Access Journals (Sweden)

    Evangeline B Handog

    2012-01-01

    Full Text Available Chemical peeling is a widely used procedure in the management of acne and acne scars, but there are very few studies on Asian populations who are more prone to develop hyper pigmentation. This article aims to summarize and evaluate the existing studies on the role of chemical peels in the treatment of acne and acne scars among Asians. An online search was conducted to identify prospective studies published in English that evaluated the use of chemical peels in active acne and acne scars in Asian populations. There were six studies for acne and eight studies for acne scars that were identified using our search parameters. Most were single-centre, open label and with small sample sizes. Acne severity was not uniformly reported and the objective outcome measures of some studies were not explicitly reported as well. The general trend of the results of the studies support the safety and efficacy of chemical peels for acne and acne scars including those of darker skin types. The existing studies support the use of chemical peels in the treatment of acne and acne scars in Asians. Further clinical trials with better study design and more subjects are needed to further establish the role of chemical peels in Asian acne patients.

  17. Efficacy and safety of combined ethinyl estradiol/drospirenone oral contraceptives in the treatment of acne

    Directory of Open Access Journals (Sweden)

    Jerry KL Tan

    2009-11-01

    Full Text Available Jerry KL Tan1, Chemanthi Ediriweera21University of Western Ontario and Windsor Clinical Research Inc., Windsor, Ontario, Canada; 2University of Western Ontario, Southwest Ontario Medical Education Network, Windsor, Ontario, CanadaAbstract: Acne is a common disorder affecting the majority of adolescents and often extends into adulthood. The central pathophysiological feature of acne is increased androgenic stimulation and/or end-organ sensitivity of pilosebaceous units leading to sebum hypersecretion and infundibular hyperkeratinization. These events lead to Propionibacterium acnes proliferation and subsequent inflammation. Hormonal therapy, including combined oral contraceptives (OCs, can attenuate the proximate androgenic trigger of this sequence. For many women, hormonal therapy is a rational option for acne treatment as it may be useful across the spectrum of severity. Drospirenone (DRSP is a unique progestin structurally related to spironolactone with progestogenic, antimineralocorticoid, and antiandrogenic properties. It is available in 2 combined OC preparations (30 µg EE/3 mg DRSP; Yasmin® in a 21/7 regimen; and 20 µg EE/3 mg DRSP; Yaz® in a 24/4 regimen. These preparations are bereft of the fluid retentional side effects typical of other progestins and their safety has been demonstrated in large epidemiological studies in which no increased risk of vascular thromboembolic disease or arrhythmias was observed. In acne, the efficacy of DRSP-containing OCs has been shown in placebo-controlled superiority trials and in active-comparator non-inferiority trials.Keywords: acne vulgaris, combined oral contraceptives, drosperinone, ethinyl estradiol, efficacy, safety, treatment

  18. Surface needle and blood-letting puncturing and cupping on back shu point for treatment of teens’vulgaris acne of syndrome%面针结合背俞穴刺络拔罐治疗青少年寻常性痤疮

    Institute of Scientific and Technical Information of China (English)

    孙慧丽; 熊桂华

    2015-01-01

    中医认为,青少年寻常性痤疮的病因病机外以风、热、寒、湿等外邪侵袭为主,内有血热、虚损等而致。采用面针结合背俞穴刺络拔罐法治疗是以面部皮损局部为中心行多针围刺,直达患处,能加快面部气血运行;根据不同证型选择相应的背俞穴行刺络拔罐治疗,可调理脏腑气血,促进脏腑生理功能。%Acne is a kind of disease that occurs in puberty. It is chronic,inflammatory and disfigured. In traditional Chinese medicine,acne is caused by wind,heat,cold,wet,blood-heat,and deficiency. Surface needle and blood-let-ting puncturing and cupping on back shu point for acne is a method that makes lesions as the center and acupunctures them,it can speed up the facial blood runs. According to different syndromes,we blood-letting puncture and cup on different back shu point. It can regulate qi and blood of Zang-Fu organs,and promote organs normal physiological function.

  19. Chemical peels for acne and acne scars in asians: Evidence based review

    OpenAIRE

    Handog, Evangeline B; Datuin, Maria Suzanne L; Singzon, Ivan A

    2012-01-01

    Chemical peeling is a widely used procedure in the management of acne and acne scars, but there are very few studies on Asian populations who are more prone to develop hyper pigmentation. This article aims to summarize and evaluate the existing studies on the role of chemical peels in the treatment of acne and acne scars among Asians. An online search was conducted to identify prospective studies published in English that evaluated the use of chemical peels in active acne and acne scars in As...

  20. Acne fulminans successfully treated with prednisone and dapsone Acne fulminans tratada com prednisona associada à dapsona

    Directory of Open Access Journals (Sweden)

    Rafael Bandeira Lages

    2012-08-01

    Full Text Available Acne fulminans is a rare condition and the most severe form of acne. It involves the sudden onset of febrile and multisystemic symptoms, with poor response to ordinary therapy in patients who previously had mild to moderate acne. It is characterized by hemorrhagic ulcerative crusting lesions on the face, chest and upper back. The authors report a case of acne fulminans that was successfully treated with oral prednisone and dapsone.A acne fulminans é uma condição rara e a mais severa forma de acne. Manifesta-se com um quadro agudo, febril e multissistêmico, resistente à terapêutica convencional em doentes com antecedente de acne leve ou moderada. As lesões são caracteristicamente úlcero-hemorrágicas e acometem preferencialmente tórax e face. Os autores relatam um caso de acne fulminans com excelente resposta terapêutica ao tratamento empregado.

  1. Do generalists and specialists agree on descriptive acne morphology?

    DEFF Research Database (Denmark)

    Yazdanyar, S; Bryld, L E; Heidenheim, M;

    2013-01-01

    BACKGROUND: Acne is a common skin disease, which is treated by many different specialities. Clinical guidelines for treatment are based on the recognition of acne morphology. The assessment of acne morphology is therefore an important element of the proper diagnosis and treatment of acne. OBJECTIVE...... in the distribution of answers. CONCLUSION: GPs described acne morphology recognized clinical hallmarks of severity in acne less well than dermatologists and were far less consistent....

  2. Acne induzida por amineptina Acne induced by amineptine

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Martins Guedes

    2009-02-01

    Full Text Available Relata-se um caso grave de lesões acne-símile associada a amineptina (Survector®, proeminentes na face e dorso, acometendo outros sítios não afetados pela acne vulgar, como períneo, braços e pernas. As lesões apareceram após a auto-administração crônica de altas doses do medicamento. Lesões ceratoacantoma-símile também estavam presentes, tendo as lesões menores resposta satisfatória ao tratamento com imiquimod tópico. O relato é significativo pela raridade da doença.

  3. Acne and diet: facts and controversies.

    Science.gov (United States)

    Rezaković, Saida; Bukvić Mokos, Zrinka; Basta-Juzbašić, Aleksandra

    2012-01-01

    Acne is a common skin disorder characterized by follicular hyperkeratinization and obstruction of the pilosebaceous follicles, androgen stimulated sebum production, colonization of the follicles by Propionibacterium acne, and inflammation. A large number of epidemiological studies have shown a low incidence of acne in non-Western societies, suggesting that diet might be an important factor in acne pathogenesis, particularly in mediating inflammation, oxidative stress and androgen stimulation in the acne process. Consequently, it has been hypothesized that diet might have a preventive or therapeutic effect in this skin disorder. Since the majority of recent data have not been consistent, the aim of this article is to present current knowledge and scientific assumptions on the relationship between diet and acne. PMID:23069302

  4. Kualitas Hidup Pasien Akne Vulgaris pada Mahasiswi Angkatan 2011 Fakultas Kedokteran Sumatera Utara

    OpenAIRE

    Fachry, M. Nevino

    2015-01-01

    Acne vulgaris (AV) is obstructive skin disease and chronic inflammation on Pilosebasea unit. The cause of AV is still unknown, but there are several factors that could affect the occurrence of AV such as sebum, bacteria, genetic issue, hormones, diet, climate, psychosocial, cosmetics, chemical liquids, and reactivity affected. Besides effecting physical symptom, AV has also impacted mental, social disturbance and emotion which influence the quality of life. The study is to determine the q...

  5. Rapid treatment of mild acne with a novel skin care system containing 1% salicylic acid, 10% buffered glycolic acid, and botanical ingredients.

    Science.gov (United States)

    Bhatia, Ashish C; Jimenez, Felipe

    2014-06-01

    The biggest hurdle in the treatment of acne vulgaris is patient non-compliance that is due in large part to poor tolerability to common acne medications. As such, new acne treatments must be developed that balance good anti-acne efficacy with excellent tolerability in order to ensure patient adherence and by extension ensure good clinical outcomes. The goal of the present study was to determine the tolerability and efficacy of a novel skin care system, composed of a cleanser, containing 1% salicylic acid and botanical ingredients, and a treatment gel, containing 1% salicylic acid, 10% buffered glycolic acid and botanical ingredients for the treatment of mild acne. In this single-center, open-label clinical study, 25 male and female volunteers used the test cleanser and test gel twice daily over six weeks. Tolerability assessments showed that the skin care regimen was very well tolerated by all study volunteers. Acne severity was significantly reduced by two acne grades at six weeks. Inflammatory lesion counts were significantly reduced, on average, by 59.06% (P ≤ 0.0001), 91.62% (P ≤ 0.0001), 90.85% (P ≤ 0.0001) and by 98.55% (P ≤ 0.0001) at weeks 1, 2, 4, and 6, respectively. Non-inflammatory lesion counts were reduced, on average, by 13.54% (ns), 38.95% (P ≤ 0.0001), 44.48% (P ≤ 0.0001), and by 56.10% (P ≤ 0.0001) at weeks 1, 2, 4, and 6, respectively. Standardized photography also demonstrated a progressive reduction in acne lesions over time. In conclusion, results of the present study suggest that the tested skin care regimen offers rapid acne clearance and excellent tolerability that together may help to improve patient adherence as well as treatment outcome.

  6. Physical modalities for treating acne and rosacea.

    Science.gov (United States)

    Jalian, H Ray; Levin, Yakir; Wanner, Molly

    2016-06-01

    Physical modalities provide an important adjunct to medical treatment of acne and rosacea. In patients who cannot tolerate or fail medical treatments, physical modalities offer an alternative approach. For cases of acne scarring, phymatous changes of rosacea, and rosacea-associated telangiectasia, physical modalities such as laser and light treatments represent the treatment of choice. We will review the use of laser and light treatments, photodynamic therapy, and other physical modalities such as targeted therapies for the treatment of acne and rosacea.

  7. Neglected aspects in the management of acne.

    OpenAIRE

    Gordon, B.

    1985-01-01

    Acne is the result of excessive grease on the skin. The successful treatment of acne depends essentially on the degreasing of the skin to an extent which produces peeling, which is the observable index of adequate treatment. The use of antibiotics is supplementary to degreasing and peeling. Degreasing is best achieved by thrice daily washing with Neutrogena acne cleansing soap, followed by the application of a benzoyl peroxide preparation of a suitable strength. If necessary, further degreasi...

  8. Moisturizers for Acne: What are their Constituents?

    OpenAIRE

    Chularojanamontri, Leena; Tuchinda, Papapit; Kulthanan, Kanokvalai; Pongparit, Kamolwan

    2014-01-01

    Acne is a chronic inflammatory disease of the pilosebaceous unit that affects almost all teenagers. Different treatments offer different modes of action, but aim to target acne pathology. Topical therapies, such as benzoyl peroxide, retinoids, antibiotics with alcohol-based preparations, and salicylic acid, can cause skin irritation resulting in a lack of patient adherence. Some physicians recommend patients use moisturizers as adjunctive treatment of acne, especially when either topical benz...

  9. Acne: the role of medical nutrition therapy.

    Science.gov (United States)

    Burris, Jennifer; Rietkerk, William; Woolf, Kathleen

    2013-03-01

    Acne is a common disease in Westernized nations, particularly among adolescents and young adults. Acne has substantial effects on quality of life, making treatment essential. Medical nutrition therapy as a potential treatment for acne is not new, although the literature examining diet and acne during the past 100 years is mixed. During the late 1800s and early 1900s, diet was commonly used as an adjunct treatment for acne. During the 1960s, however, the diet-acne connection fell out of favor. In recent years, dermatologists and registered dietitians have revisited the idea and become increasingly interested in the role of medical nutrition therapy in acne treatment. This article reviews the history and existing literature examining the association between diet and acne. Although the total number of studies conducted within the past 40 years is relatively small, the growing body of epidemiologic and experimental evidence suggests a relationship between diet and acne. Compared with other dietary factors, more research examines dietary glycemic load. The evidence is more convincing for high glycemic load diets, compared with other dietary factors. To date there are no randomized controlled trials investigating the relationship between frequent dairy or milk consumption and acne. Similarly, the number of research studies examining the relationship between dietary fat and/or n-3 fatty acids is sparse and the evidence is less robust. Taken together, several methodologic limitations need to be addressed, and additional research, preferably randomized controlled trials, is warranted before comprehensive evidence-based guidelines can be established. While dermatologists and registered dietitians continue to debate and research the potential relationship between diet and acne, the best dietary approach is to address each acne patient individually, carefully considering the possibility of dietary counseling. PMID:23438493

  10. [Using combined magnetotherapy in patients with acne].

    Science.gov (United States)

    Kul'chitskaia, D B; Orekhova, E M; Vasil'eva, E S

    2004-01-01

    Laser Doppler flowmetry discovered microcirculatory disorders in acne patients. Affected are arterioles as well as capillaries and venules. Combination of magnetotherapy with medication improves microcirculation in acne patients. More marked positive changes occurred in the microcirculatory system due to combined treatment compared to medication therapy only. Thus, laser Doppler flowmetry is a new, noninvasive method of assessing microcirculation in acne patients and can serve an objective criterion of treatment efficacy. PMID:15449670

  11. Standard guidelines of care for acne surgery

    Directory of Open Access Journals (Sweden)

    Khunger Niti

    2008-03-01

    Full Text Available Acne surgery is the use of various surgical procedures for the treatment of postacne scarring and also, as adjuvant treatment for active acne. Surgery is indicated both in active acne and post-acne scars. Physicians′ qualifications: Any Dermatologist can perform most acne surgery techniques as these are usually taught during postgraduation. However, certain techniques such as dermabrasion, laser resurfacing, scar revisions need specific "hands-on" training in appropriate training centers. Facility: Most acne surgery procedures can be performed in a physician′s minor procedure room. However, full-face dermabrasion and laser resurfacing need an operation theatre in a hospital setting. Active acne: Surgical treatment is only an adjunct to medical therapy, which remains the mainstay of treatment. Comedone extraction is a process of applying simple mechanical pressure with a comedone extractor, to extract the contents of the blocked pilosebaceous follicle. Superficial chemical peel is a process of applying a chemical agent to the skin, so as to cause controlled destruction of the epidermis leading to exfoliation. Glycolic acid, salicylic acid and trichloroacetic acid are commonly used peeling agents for the treatment of active acne and superficial acne scars. Cryotherapy: Cryoslush and cryopeel are used for the treatment of nodulocystic acne. Intralesional corticosteroids are indicated for the treatment of nodules, cysts and keloidal acne scars. Nonablative lasers and light therapy using Blue light, non ablative radiofrequency, Nd:YAG laser, IPL (Intense Pulsed Light, PDT (Photodynamic Therapy, pulse dye laser and light and heat energy machines have been used in recent years for the treatment of active inflammatory acne and superficial acne scars. Proper counseling is very important in the treatment of acne scars. Treatment depends on the type of acne scars; a patient may need more than one type of treatment. Subcision is a treatment to break the

  12. Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study

    Directory of Open Access Journals (Sweden)

    Alessandrini G

    2012-02-01

    Full Text Available Enzo Emanuele1, Marco Bertona1, Karmela Altabas2, Velimir Altabas2, Giuseppe Alessandrini31Department of Health Sciences, University of Pavia, Pavia, Italy; 2Clinical Hospital "Sestre Milosrdnice", Zagreb, Croatia; 3Dermatology Clinics, Ugento, ItalyPurpose: Acne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Aberrant extracellular matrix remodeling due to matrix metalloproteinases (MMPs has been associated with the presence of acne conditions. Given the complex pathophysiology of acne, novel topical therapies should include combination products that target multiple pathogenetic mechanisms. In this pilot study we investigated the changes in gene expression of extracellular MMPs, the tissue inhibitors of metalloproteinases, and proinflammatory molecules after 45 days of topical application of a combination product containing nicotinamide, retinol, and 7-dehydrocholesterol in 16 patients with inflammatory acne on their back.Materials and methods: Skin biopsies were obtained before and after treatment for gene expression studies.Results: Quantitative real-time polymerase chain reaction revealed a significant downregulation of MMP-1, MMP-2, MMP-9, MMP-14, interleukin-6, monocyte chemoattractant protein-1, and macrophage migration inhibitory factor. In contrast, the tissue inhibitors of metalloproteinases and transforming growth factor-ß1 were significantly upregulated. The gene expression findings correlated well with the clinical treatment response.Conclusions: The combination of nicotinamide, retinol, and 7-dehydrocholesterol appears to be effective for acne treatment from both clinical and molecular standpoints.Keywords: acne, gene expression, topical treatment, matrix metalloproteinases, inflammation

  13. Zapping Those Zits: Helping Teens Handle Acne.

    Science.gov (United States)

    Martin, Paul

    1992-01-01

    Describes five types of acne and stresses the importance of appropriate treatment. Some dermatologists believe diet is critical in improving acne. Other treatments include the use of drying lotions and soaps, astringents, abrasive cleansers, prescription drugs, face peels, and dermabrasion. (SM)

  14. Moisturizers for Acne: What are their Constituents?

    Science.gov (United States)

    Chularojanamontri, Leena; Tuchinda, Papapit; Kulthanan, Kanokvalai; Pongparit, Kamolwan

    2014-05-01

    Acne is a chronic inflammatory disease of the pilosebaceous unit that affects almost all teenagers. Different treatments offer different modes of action, but aim to target acne pathology. Topical therapies, such as benzoyl peroxide, retinoids, antibiotics with alcohol-based preparations, and salicylic acid, can cause skin irritation resulting in a lack of patient adherence. Some physicians recommend patients use moisturizers as adjunctive treatment of acne, especially when either topical benzoyl peroxide or a retinoid is prescribed. Furthermore, some evidence shows that moisturizers can contribute independently to improve signs and symptoms of acne. Moisturizers contain three main properties, which are occlusive, humectant, and emollient effects. Currently, many moisturizers claim to be suitable for acne treatment. This article aims to provide a review of the active ingredients and properties of those moisturizers. Fifty-two moisturizers for acne were included for analysis. Most of the products (92%) have anti-inflammatory properties apart from occlusive, humectant, and emollient effects. Anti-acne medications, including salicylic acid, benzoyl peroxide, and retinol, were found respectively in 35, 10, and 8 percent of the moisturizer products containing anti-inflammatory properties. More than half of the products contain dimethicone and/or glycerin for its moisturizer property. Aloe vera and witch hazel are botanical anti-inflammatories that were commonly found in this study. Scientific data regarding some ingredients are discussed to provide a guide for physicians in selecting moisturizers for acne patients. PMID:24847408

  15. The flexible gene pool of Propionibacterium acnes

    DEFF Research Database (Denmark)

    Brüggemann, Holger; Lomholt, Hans B; Kilian, Mogens

    2012-01-01

    palindromic repeats (CRISPR), found exclusively in type II P. acnes, recently revealed the presence of CRISPR spacers that derived from mobile genetic elements. These elements are present in a subset of P. acnes type I lineages. Their significance for type-specific host-interacting properties...

  16. Infantile acne treated with oral isotretinoin

    DEFF Research Database (Denmark)

    Miller, Iben Marie; Echeverría, Begoña; Torrelo, Antonio;

    2013-01-01

    In contrast to adolescent acne, infantile acne (IA) is a rare condition with only a limited body of available literature. In this descriptive, retrospective study, we reviewed six cases from 2002 to 2010 treated with oral isotretinoin. The average age of onset was 6.16 months (range 0-21 mos...

  17. Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study

    OpenAIRE

    Alessandrini G; Altabas V; Altabas K; Bertona M; Emanuele E

    2012-01-01

    Enzo Emanuele1, Marco Bertona1, Karmela Altabas2, Velimir Altabas2, Giuseppe Alessandrini31Department of Health Sciences, University of Pavia, Pavia, Italy; 2Clinical Hospital "Sestre Milosrdnice", Zagreb, Croatia; 3Dermatology Clinics, Ugento, ItalyPurpose: Acne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Aberrant extracellular matrix remodeling due to matrix metalloproteinases (MMPs) has been associ...

  18. Over-the-counter Acne Treatments: A Review

    OpenAIRE

    Decker, Ashley; Graber, Emmy M.

    2012-01-01

    Acne is a common dermatological disorder that most frequently affects adolescents; however, individuals may be affected at all ages. Many people who suffer from acne seek treatment from both prescription and over-the-counter acne medications. Due to convenience, lower cost, and difficulty getting an appointment with a dermatologist, the use of over-the-counter acne treatments is on the rise. As the plethora of over-the-counter acne treatment options can be overwhelming, it is important that d...

  19. Pseudo-acne fulminans associated with oral isotretinoin *

    OpenAIRE

    Grando, Luciana Rosa; Leite, Oriete Gerin; Cestari, Tania Ferreira

    2014-01-01

    Acne fulminans is a rare and serious condition characterized by the sudden onset of nodular and ulcerative acne lesions associated with systemic symptoms. It has been recognized a subset of patients with a sudden worsening of acne, often during treatment with oral isotretinoin, but without the strong presence of systemic involvement. Recognized by some authors as "pseudo-acne fulminans" or " acne fulminans sine fulminans," we report a case with these features in order to draw attention to the...

  20. Acne is not Associated with yet Uncultured Bacteria

    DEFF Research Database (Denmark)

    Bek-Thomsen, Malene; Lomholt, Hans Bredsted; Kilian, Mogens

    2008-01-01

    Current clinical and microbiological information on acne fail to demonstrate a clear association between particular species, including Propionibacterium acnes, and disease, and the disease continues to be a considerable problem. To test if acne is associated with hitherto uncultured bacteria...... excludes that acne is associated with yet uncultured bacteria and shows that healthy skin follicles constitute a remarkably exclusive habitat allowing colonization only by P. acnes....

  1. Effects of fish oil supplementation on inflammatory acne

    OpenAIRE

    Khayef Golandam; Young Julia; Burns-Whitmore Bonny; Spalding Thomas

    2012-01-01

    Abstract Background Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity. Methods 13 individuals with inflammatory acne were given three grams of fish oil containing 930 mg of EPA to their unchanged diet and existing acne remedies for 12 weeks. Acne was assessed using an overall severity grading scale, total inflamm...

  2. Update and future of systemic acne treatment.

    Science.gov (United States)

    Zouboulis, Christos C; Piquero-Martin, Jaime

    2003-01-01

    Systemic treatment is required in patients with moderate-to-severe acne, especially when acne scars start to occur. Antibiotics with anti-inflammatory properties, such as tetracyclines (oxytetracycline, tetracycline chloride, doxycycline, minocycline and limecycline) and macrolide antibiotics (erythromycin and azithromycin) are the agents of choice for papulopustular acne, even though the emerging resistant bacterial strains are minimizing their effect, especially regarding erythromycin. Systemic antibiotics should be administered during a period of 8-12 weeks. In severe papulopustular and in nodulocystic/conglobate acne, oral isotretinoin is the treatment of choice. Hormonal treatment represents an alternative regimen in female acne, whereas it is mandatory in resistant, severe pubertal or post-adolescent forms of the disease. Compounds with anti-androgenic properties include estrogens combined with progestins, such as ethinyl estradiol with cyproterone acetate, chlormadinone acetate, desogestrel, drospirenone, levonogestrel, norethindrone acetate, norgestimate, and other anti-androgens directly blocking the androgen receptor (flutamide) or inhibiting androgen activity at various levels, corticosteroids, spironolactone, cimetidine, and ketoconazole. After 3 months of treatment control of seborrhea and acne can be obtained. Low-dose corticosteroids (prednisone, prednisolone, or dexamethasone) are indicated in patients with adrenal hyperandrogenism or acne fulminans. New developments and future trends represent low-dose long-term isotretinoin regimens, new isotretinoin formulations (micronized isotretinoin), isotretinoin metabolites, combination treatments to reduce toxicity, insulin-sensitizing agents, 5alpha-reductase type 1 inhibitors, antisense oligonucleotide molecules, and, especially, new anti-inflammatory agents, such as lipoxygenase inhibitors. PMID:12566804

  3. Acne da mulher adulta: aspectos epidemiológicos, diagnósticos e terapêuticos Acne in adult women: epidemiological, diagnostic and therapeutic aspects

    Directory of Open Access Journals (Sweden)

    Flavia Alvim Sant'Anna Addor

    2010-12-01

    treatment and evolution. RESULTS: The mean age was 33.9 years and the predominant clinical grade of acne was moderate inflammatory (grade 2. The face was the most affected area. Topical retinoids were the most prescribed drugs, and systemic medication was prescribed to 53.4% of the patients. Total regression was observed in 31 patients (26.7% within 12 weeks of treatment. Adverse reactions to topical treatment occurred in 21.5% of the patients. CONCLUSION: The clinical manifestations of AFA in patients without hyperandrogenism are moderate, with predominance of inflammatory lesions. Treatment is similar to that of acne vulgaris; however, special attention should be taken with more irritating medication since this group appears to be more predisposed to skin irritations.

  4. Acne image analysis: lesion localization and classification

    Science.gov (United States)

    Abas, Fazly Salleh; Kaffenberger, Benjamin; Bikowski, Joseph; Gurcan, Metin N.

    2016-03-01

    Acne is a common skin condition present predominantly in the adolescent population, but may continue into adulthood. Scarring occurs commonly as a sequel to severe inflammatory acne. The presence of acne and resultant scars are more than cosmetic, with a significant potential to alter quality of life and even job prospects. The psychosocial effects of acne and scars can be disturbing and may be a risk factor for serious psychological concerns. Treatment efficacy is generally determined based on an invalidated gestalt by the physician and patient. However, the validated assessment of acne can be challenging and time consuming. Acne can be classified into several morphologies including closed comedones (whiteheads), open comedones (blackheads), papules, pustules, cysts (nodules) and scars. For a validated assessment, the different morphologies need to be counted independently, a method that is far too time consuming considering the limited time available for a consultation. However, it is practical to record and analyze images since dermatologists can validate the severity of acne within seconds after uploading an image. This paper covers the processes of region-ofinterest determination using entropy-based filtering and thresholding as well acne lesion feature extraction. Feature extraction methods using discrete wavelet frames and gray-level co-occurence matrix were presented and their effectiveness in separating the six major acne lesion classes were discussed. Several classifiers were used to test the extracted features. Correct classification accuracy as high as 85.5% was achieved using the binary classification tree with fourteen principle components used as descriptors. Further studies are underway to further improve the algorithm performance and validate it on a larger database.

  5. Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds.

    Science.gov (United States)

    Coenye, Tom; Brackman, Gilles; Rigole, Petra; De Witte, Evy; Honraet, Kris; Rossel, Bart; Nelis, Hans J

    2012-03-15

    Propionibacterium acnes is a Gram-positive bacterium that plays an important role in the pathogenesis of acne vulgaris. This organism is capable of biofilm formation and the decreased antimicrobial susceptibility of biofilm-associated cells may hamper efficient treatment. In addition, the prolonged use of systemic antibiotic therapy is likely to lead to the development and spread of antimicrobial resistance. In the present study we investigated whether P. acnes biofilms could be eradicated by plant extracts or their active compounds, and whether other mechanisms besides killing of biofilm cells could be involved. Out of 119 plant extracts investigated, we identified five with potent antibiofilm activity against P. acnes (extracts from Epimedium brevicornum, Malus pumila, Polygonum cuspidatum, Rhodiola crenulata and Dolichos lablab). We subsequently identified icariin, resveratrol and salidroside as active compounds in three of these extracts. Extracts from E. brevicornum and P. cuspidatum, as well as their active compounds (icariin and resveratrol, respectively) showed marked antibiofilm activity when used in subinhibitory concentrations, indicating that killing of microbial cells is not their only mode of action. PMID:22305279

  6. Acne and whey protein supplementation among bodybuilders.

    Science.gov (United States)

    Simonart, Thierry

    2012-01-01

    Accumulative evidence supports the role of nutritional factors in acne. I report here 5 healthy male adult patients developing acne after the consumption of whey protein, a favorite supplement of those engaged in bodybuilding. These observations are in line with biochemical and epidemiological data supporting the effects of milk and dairy products as enhancers of insulin/insulin-like growth factor 1 signaling and acne aggravation. Further prospective studies are required to determine the possible role of dietary supplements in the fitness and bodybuilding environment.

  7. Physical modalities for treating acne and rosacea.

    Science.gov (United States)

    Jalian, H Ray; Levin, Yakir; Wanner, Molly

    2016-06-01

    Physical modalities provide an important adjunct to medical treatment of acne and rosacea. In patients who cannot tolerate or fail medical treatments, physical modalities offer an alternative approach. For cases of acne scarring, phymatous changes of rosacea, and rosacea-associated telangiectasia, physical modalities such as laser and light treatments represent the treatment of choice. We will review the use of laser and light treatments, photodynamic therapy, and other physical modalities such as targeted therapies for the treatment of acne and rosacea. PMID:27416315

  8. Diet in acne: further evidence for the role of nutrient signalling in acne pathogenesis.

    Science.gov (United States)

    Melnik, Bodo C

    2012-05-01

    Recent evidence underlines the role of Western diet in the pathogenesis of acne. Acne is absent in populations consuming Palaeolithic diets with low glycaemic load and no consumption of milk or dairy products. Two randomized controlled studies, one of which is presented in this issue of Acta Dermato-Venereologica, have provided evidence for the beneficial therapeutic effects of low glycaemic load diets in acne. Epidemiological evidence confirms that milk consumption has an acne-promoting or acne-aggravating effect. Recent progress in understanding the nutrient-sensitive kinase mammalian target of rapamycin complex 1 (mTORC1) allows a new view of nutrient signalling in acne by both high glycaemic load and increased insulin-, IGF-1-, and leucine signalling due to milk protein consumption. Acne should be regarded as an mTORC1-driven disease of civilization, like obesity, type 2 diabetes and cancer induced by Western diet. Early dietary counselling of teenage acne patients is thus a great opportunity for dermatology, which will not only help to improve acne but may reduce the long-term adverse effects of Western diet on more serious mTORC1-driven diseases of civilization. PMID:22419445

  9. Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne.

    Directory of Open Access Journals (Sweden)

    Hans B Lomholt

    Full Text Available The involvement of Propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin. This study tested the hypothesis that specific evolutionary lineages of the species are associated with acne while others are compatible with health. Phylogenetic reconstruction based on nine housekeeping genes was performed on 210 isolates of P. acnes from well-characterized patients with acne, various opportunistic infections, and from healthy carriers. Although evidence of recombination was observed, the results showed a basically clonal population structure correlated with allelic variation in the virulence genes tly and camp5, with pulsed field gel electrophoresis (PFGE- and biotype, and with expressed putative virulence factors. An unexpected geographically and temporal widespread dissemination of some clones was demonstrated. The population comprised three major divisions, one of which, including an epidemic clone, was strongly associated with moderate to severe acne while others were associated with health and opportunistic infections. This dichotomy correlated with previously observed differences in in vitro inflammation-inducing properties. Comparison of five genomes representing acne- and health-associated clones revealed multiple both cluster- and strain-specific genes that suggest major differences in ecological preferences and redefines the spectrum of disease-associated virulence factors. The results of the study indicate that particular clones of P. acnes play an etiologic role in acne while others are associated with health.

  10. Properties of herbal extracts against Propionibacterium acnes for biomedical application

    Science.gov (United States)

    Lim, Youn-Mook; Kim, Sung Eun; Kim, Yong Soo; Shin, Young Min; Jeong, Sung In; Jo, Sun-Young; Gwon, Hui-Jeong; Park, Jong-seok; Nho, Young-Chang; Kim, Jong-Cheol; Kim, Seong-Jang; Shin, HeungSoo

    2012-10-01

    Propionibacterium acnes (P. acnes), one of the anaerobic bacterium, causes inflammatory acne. To find a novel medication for treating the inflammation caused by P. acnes, we investigated the anti-bacterial and anti-inflammatory activities of several herbal extracts against P. acnes. The aqueous extracts from five dried herbs, Phellodendron amurense Rupr., Paeonia lactiflora Pallas., Houttuynia cordata Thunb., Agrimonia pilosa Ledeb. and Glycyrrhiza uralensis Fisch., were prepared and mixed. In this experiment, 1 mg/ml of the herbal extract mixture caused a decrease in the growth of P. acnes and reduced the production of pro-inflammatory cytokines, TNF-α, IL-8, IL-1β and IL-6, in human monocytic THP-1 cells treated with heat-killed P. acnes. Therefore, this herbal extract mixture may possess both anti-bacterial and anti-inflammatory activities against P. acnes and can be a novel therapeutic agent for treating inflammatory acne.

  11. What's new in the physiopathology of acne?

    Science.gov (United States)

    Suh, D H; Kwon, H H

    2015-07-01

    There are four central factors that contribute to acne physiopathology: the inflammatory response, colonization with Propionibacterium acnes, increased sebum production and hypercornification of the pilosebaceous duct. In addition, research in the areas of diet and nutrition, genetics and oxidative stress is also yielding some interesting insights into the development of acne. In this paper we review some of the most recent research and novel concepts revealed in this work, which has been published by researchers from diverse academic disciplines including dermatology, immunology, microbiology and endocrinology. We discuss the implications of their findings (particularly in terms of opportunities to develop new therapies), highlight interrelationships between these novel factors that could contribute to the pathology of acne, and indicate where gaps in our understanding still exist. PMID:25645151

  12. What's new in acne and rosacea?

    Science.gov (United States)

    Keri, Jonette

    2016-06-01

    Acne and rosacea are common conditions seen every day by dermatologists. This review will discuss the most recent therapeutic options for patients with these conditions. Specifically, for acne, there will be a discussion of the use of isotretinoin at higher cumulative doses as well as a new formulation of isotretinoin, isotretinoin-lidose. Adult women with acne represent a growing population of patients who present for treatment of acne; the use of hormonal therapies as well as topical dapsone gel will be reviewed for these patients. For rosacea patients, the new topical agents - brimonidine gel and ivermectin cream - will be reviewed, with a discussion on possible rebound phenomenon from brimonidine. Finally, future treatments in the pipeline will be discussed. PMID:27416316

  13. Lupus vulgaris of external nose

    OpenAIRE

    Bhandary, Satheesh Kumar; Ranganna, B. Usha

    2008-01-01

    Lupus vulgaris is the commonest form of cutaneous tuberculosis which commonly involve trunk and buttocks. Lupus vulgaris affecting nose and face, are rarely reported in India. This study reports an unusual case of lupus vulgaris involving the external nose that showed dramatic outcome after six months of anti- tubercular treatment.

  14. Lupus vulgaris of external nose.

    Science.gov (United States)

    Bhandary, Satheesh Kumar; Ranganna, B Usha

    2008-12-01

    Lupus vulgaris is the commonest form of cutaneous tuberculosis which commonly involve trunk and buttocks. Lupus vulgaris affecting nose and face, are rarely reported in India. This study reports an unusual case of lupus vulgaris involving the external nose that showed dramatic outcome after six months of anti- tubercular treatment.

  15. Lupus vulgaris: difficulties in diagnosis.

    Science.gov (United States)

    Rhodes, Julia; Caccetta, Tony Philip; Tait, Clare

    2013-05-01

    Lupus vulgaris is one of the most common forms of cutaneous tuberculosis. It presents a diagnostic challenge due to its paucibacillary nature. This is a report of a case of a delayed diagnosis of lupus vulgaris, presenting as perianal and peristomal plaques, followed by a review of the diagnostic tools for lupus vulgaris and their limitations.

  16. Decreased vitamin B 12 and folic acid concentrations in acne patients after isotretinoin therapy: A controlled study

    Directory of Open Access Journals (Sweden)

    Hilal Gökalp

    2014-01-01

    Full Text Available Background: Oral isotretinoin treatment might influence the levels of vitamin B 12 and folic acid. Aims and Objectives: The aim of this study is to compare vitamin B 12 and folic acid levels in patients with moderate and severe acne vulgaris with those of the healthy control group and to investigate the effect of isotretinoin treatment on these vitamins. Materials and Methods: Patients who completed 6 months of isotretinoin therapy for moderate and severe forms of acne vulgaris and a control group consisting of healthy individuals between February 2011 and March 2012 were included in the study. Before isotretinoin therapy and at 6.- months of the therapy, serum vitamin B 12 and folic acid levels were measured. In the healthy control group, vitamin B 12 and folic acid levels were assessed only once. Results: In total, 120 patients with moderate and severe acne vulgaris who completed 6 months isotretinoin therapy and 100 healthy individuals who constituted the control group were included in the study. Pre-treatment vitamin B 12 values of the patient group were found to be statistically significantly higher (P = 0.002, but any statistically significant difference was not detected in folic acid measurements (P = 0.566. A statistically significant decrease was detected in post-treatment vitamin B 12 and folic acid levels (P < 0.05. Conclusion: Vitamin B 12 /folic acid treatment should be given under medical surveillance before and during isotretinoin therapy. Supplementation of these vitamins should be recommended in cases of their deficiency, so as to decrease the risks of neuropsychiatric and occlusive vascular diseases.

  17. 红蓝光联合陈氏粉刺清治疗痤疮的疗效观察%Therapeutic effect of acne treated by red and blue light combine with Chen's Acne Clear

    Institute of Scientific and Technical Information of China (English)

    林湘群; 李为儒

    2011-01-01

    探讨联合应用红蓝光及陈氏粉刺清治疗炎症性痤疮的临床效果.方法:选择中重度(Pillsbury分级为Ⅱ或Ⅲ度)寻常性痤疮92例,随机分为试验组(46例)和对照组(46例).试验组采用红蓝光与陈氏粉刺清联合治疗,对照组单用陈氏粉刺清治疗,研究分析其治疗效果.结果:总体效果评价中,试验组痊愈率为21.7%,有效率为82.6%;对照组痊愈率为10.8%,有效率为54.3%,比较两组之间痊愈率及有效率均有显著性差异(P<0.05).结论:红蓝光与粉刺清联合治疗炎症性痤疮疗效好,其疗效明显优于单用粉刺清治疗,不良反应亦轻微.%Objective To evaluate the clinical therapeutic effect of the red and blue light combine with Chen's acne clear for acne. And to explore the therapeutic effect. Methods Choose moderate to severe (Pillsbury classification of Ⅱ or Ⅲ degree) of acne vulgaris 92 patients, Divided into experimental group (46 cases) and control group (46 cases) randomly. Experimental group were treated with red and blue combined with Chen's acne Clear, control group only were treated with Chen's Acne clear, Observe and evaluate its therapeutic effect. Results The cure rate was 21.7%, the effective rate was 82.6% in experimental group, the cure rate was 10.8% and the effective rate was 54.3% in control group, between the two groups, cure rates and efficiency rates were with statistical significance (P<0.05).Only one case appeared skin turn red. Conclusion Combination Red and blue Light and Chen's Acne Clear therapy for inflammatory acne seems to be superior to use Chen's Acne Clear alone, and side effects were minimal

  18. Light-based therapies in acne treatment

    OpenAIRE

    Susan Pei; Inamadar, Arun C.; Keshavmurthy A Adya; Maria M Tsoukas

    2015-01-01

    The use of light and laser in the treatment of acne is increasing as these modalities are safe, effective, and associated with no or minimal complications when used appropriately. These light and laser sources are also being used in combination with pharmacological and/or physical measures to synergize their effects and optimize the therapeutic outcome. This review focuses on optical devices used in treating acne and serves to delineate the current application of various methods, including th...

  19. Comparative genomics and transcriptomics of Propionibacterium acnes.

    Directory of Open Access Journals (Sweden)

    Elzbieta Brzuszkiewicz

    Full Text Available The anaerobic gram-positive bacterium Propionibacterium acnes is a human skin commensal that is occasionally associated with inflammatory diseases. Recent work has indicated that evolutionary distinct lineages of P. acnes play etiologic roles in disease while others are associated with maintenance of skin homeostasis. To shed light on the molecular basis for differential strain properties, we carried out genomic and transcriptomic analysis of distinct P. acnes strains. We sequenced the genome of the P. acnes strain 266, a type I-1a strain. Comparative genome analysis of strain 266 and four other P. acnes strains revealed that overall genome plasticity is relatively low; however, a number of island-like genomic regions, encoding a variety of putative virulence-associated and fitness traits differ between phylotypes, as judged from PCR analysis of a collection of P. acnes strains. Comparative transcriptome analysis of strains KPA171202 (type I-2 and 266 during exponential growth revealed inter-strain differences in gene expression of transport systems and metabolic pathways. In addition, transcript levels of genes encoding possible virulence factors such as dermatan-sulphate adhesin, polyunsaturated fatty acid isomerase, iron acquisition protein HtaA and lipase GehA were upregulated in strain 266. We investigated differential gene expression during exponential and stationary growth phases. Genes encoding components of the energy-conserving respiratory chain as well as secreted and virulence-associated factors were transcribed during the exponential phase, while the stationary growth phase was characterized by upregulation of genes involved in stress responses and amino acid metabolism. Our data highlight the genomic basis for strain diversity and identify, for the first time, the actively transcribed part of the genome, underlining the important role growth status plays in the inflammation-inducing activity of P. acnes. We argue that the disease

  20. Tratamento da papilomatose canina com Propionibacterium acnes Treatment of canine papillomatosis using Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    J. Megid

    2001-10-01

    Full Text Available Propionibacterium acnes as immunostimulant in oral canine papillomatosis treatment in 16 animals was studied. Regression of the pappiloma started being observed after the second aplication, with complete resolution in all dogs after the sixth aplication. These results suggest the use of P. acnes as an alternative in oral canine papillomatosis therapy.

  1. Acne e dieta: verdade ou mito? Acne and diet: truth or myth?

    Directory of Open Access Journals (Sweden)

    Adilson Costa

    2010-06-01

    Full Text Available Nos últimos 50 anos, foram publicados inúmeros estudos com a finalidade de comprovar se a dieta está relacionada à etiologia da acne. Embora existam estudos antigos, que são bem difundidos entre os dermatologistas e negam a associação entre acne e dieta, seu delineamento científico é pobre. Recentemente, novos artigos demonstraram evidências contrárias às publicações anteriores. Sendo assim, os autores realizaram esta revisão bibliográfica com o intuito de averiguar se a dieta influencia direta ou indiretamente um ou mais dos quatro pilares etiopatogênicos fundamentais da acne: (1 hiperproliferação dos queratinócitos basais, (2 aumento da produção sebácea, (3 colonização pelo Propionibacterium acnes e (4 inflamação.Numerous studies were published over the last 50 years to investigate whether diet is associated with the etiology of acne. Although older studies well known by dermatologists that refute the association between acne and diet exist, their scientific foundation is weak. New articles have recently brought to light evidence contrary to previous findings. Therefore, we would like to investigate whether diet, directly or indirectly, influences one or more of the four fundamental etiopathogenic pillars of acne: (1 hyperproliferation of basal keratinocytes, (2 increase of sebaceous production, (3 colonization by Propionibacterium acnes, and (4 inflammation.

  2. Effects of fish oil supplementation on inflammatory acne

    Directory of Open Access Journals (Sweden)

    Khayef Golandam

    2012-12-01

    Full Text Available Abstract Background Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3 relative to omega-6 (n-6 fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity. Methods 13 individuals with inflammatory acne were given three grams of fish oil containing 930 mg of EPA to their unchanged diet and existing acne remedies for 12 weeks. Acne was assessed using an overall severity grading scale, total inflammatory lesion counts, and colorimetry. Findings There was no significant change in acne grading and inflammatory counts at week 12 compared to baseline. However, there was a broad range of response to the intervention on an individual basis. The results showed that acne severity improved in 8 individuals, worsened in 4, and remained unchanged in 1. Interestingly, among the individuals who showed improvement, 7 were classified as having moderate to severe acne at baseline, while 3 of the 4 whose acne deteriorated were classified as having mild acne. Conclusion There is some evidence that fish oil supplementation is associated with an improvement in overall acne severity, especially for individuals with moderate to severe acne. Divergent responses to fish oil in our pilot study indicates that dietary and supplemental lipids are worthy of further investigation in acne.

  3. Psoriasiform lupus vulgaris.

    Science.gov (United States)

    Padmavathy, L; Rao, L Lakshmana; Ethirajan, N; Dhanlaklshmi, M

    2008-04-01

    Tuberculosis is a major public health problem in both developing and developed countries. Cutaneous Tuberculosis constitutes a minor proportion of extra-pulmonary manifestations of Tuberculosis. Lupus Vulgaris (LV) is one of the clinical variants of Cutaneous Tuberculosis. A case of a large plaque type psoriasiform lesion of lupus vulgaris on the thigh, of 15 years' duration, in an 18-year-old girl is reported. This case highlights the ignorance level among the patients and consequent failure to avail proper anti-tuberculous treatment despite campaign in print and audio visual media.

  4. 痤疮丙酸杆菌与痤疮%Propionibacterium acnes and acne

    Institute of Scientific and Technical Information of China (English)

    王博; 赵肖庆; 郑捷

    2010-01-01

    痤疮丙酸杆菌的结构、分布和生理特点决定其在痤疮发病中的重要作用,尤其与痤疮的炎症损害及严重程度密切有关.目前,针对痤疮丙酸杆菌的痤疮治疗方法众多,包括应用四环素类、克林霉素、红霉素等治疗和过氧苯甲酰或5-氨基酮戊酸光动力疗法等.由于耐药性痤疮丙酸杆菌的出现,抗生素与非抗生素类药物的联合疗法已被证明为最佳治疗手段.痤疮丙酸杆菌全部基因组序列的测定使针对痤疮的菌苗疗法成为可能.%Propionibacterium acnes plays an essential role in the pathogenesis of acne, and is closely associated with the inflammation in and severity of acne, which may be attributed to the structure, colonization and physiological features of this pathogen. Now, many P. acnes-targeted strategies have been developed to treat acne, including antibiotic regimens such as tetracycline, clindamycin, erythromycin, nonantibiotic regimens such as benzoyl peroxide and photodynamic therapy with ALA. With the emergence of antibiotic-resistant P. acnes, the combination of antibiotic and non-antibiotic drugs has proved to be the optimized treatment for acne. The revealment of complete genome sequence of P. acnes has made it possible to treat acne with vaccines targeting P. acnes.

  5. FDA OKs Non-Prescription Use of Acne Drug

    Science.gov (United States)

    ... 159779.html FDA OKs Non-Prescription Use of Acne Drug Differin Gel 0.1% is first retinoid ... July 8, 2016 (HealthDay News) -- Good news for acne sufferers: The U.S. Food and Drug Administration has ...

  6. Development of Acne therapeutic hydrogel patches by radiation technology

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Younmook; Nho, Youngchang; Gwon, Huijeong; Park, Jongseok; Kim, Jinkyu; Kim, Yongsoo

    2012-04-15

    In this project, hydrogel patches containing herbal extracts mixture were developed by radiation technology for acne treatment. Propionibacterium acnes (P. acnes), one of the anaerobic bacterium, is the cause of inflammatory acne. To find novel mediation for inflammation of P. acnes, we confirmed the anti-bacterial and anti-inflammatory activities of several herbal extracts against P. acnes. The water extracts from five dried herbs, Phellodendron amurense Rupr., Paeonia lactiflora Pallas., Houttuynia cordata Thumb., Agrimonia pilosa Ledeb. and Glycyrrhiza uralensis Fisch., were mixed into biocompatible polymers and irradiated by using gamma-ray to prepare hydrogels. The hydrogels containing herbal extracts mixture initiated to decrease the growth of P. acnes and reduced the production of pro-inflammatory cytokines, TNF-{alpha}, IL-8, IL-1{beta} and IL-6, in experiment with human monocytic THP-1 cells treated with heat-killed P. acnes at 1 mg/ml of mixture concentration.

  7. Diet and acne: an exploratory survey study of patient beliefs

    OpenAIRE

    Nguyen, Quynh-Giao; Markus, Ramsey; Katta, Rajani

    2016-01-01

    Background: In the past, medical literature reflected that diet was not a proven cause of acne. However, studies in recent years have substantiated a link between certain dietary factors and acne. It is unclear whether patients are aware of recent research findings. Objectives: Acne patients were surveyed to explore beliefs regarding the link between diet and acne, to determine whether these beliefs translated into behavior change and to identify health information sources. Patients/Methods: ...

  8. An innovative approach to the topical treatment of acne

    OpenAIRE

    Sparavigna A; Tenconi B; De Ponti I; La Penna L

    2015-01-01

    Adele Sparavigna, Beatrice Tenconi, Ileana De Ponti, Laura La PennaDermIng srl, Clinical Research and Bioengineering Institute, Monza, MB, ItalyAbstract: Acne is characterized by primary lesions on the face, chest, and back, and by a variety of other signs and symptoms. In particular, acne inflammatory lesions result from Propionibacterium acnes colonization and are of particular relevance as they can cause permanent scarring. Acne also causes significant psychological morbidity in affected p...

  9. Consequences of psychological distress in adolescents with acne.

    Science.gov (United States)

    Misery, Laurent

    2011-02-01

    Acne may cause psychological distress that is associated with many psychiatric disorders. In this issue, Halvorsen et al. report suicidal ideation, mental health problems, and affective isolation to be relatively frequent in adolescents with acne. This report suggests that adverse events that have been attributed to therapies for acne, including suicidal ideation and depression, may reflect the burden of substantial acne rather than the effect of medications.

  10. Lupus vulgaris on keloid

    Directory of Open Access Journals (Sweden)

    Jena S

    2002-01-01

    Full Text Available A 28-year-old man presented with multicentric lupus vulgaris on keloids over chest, axilla, neck and back for last 6 months. He had pulmonary tuberculosis. All the laboratory investigations were in favour of clinical diagnosis. The patient responded to antituberculosis therapy.

  11. Atrophic Acne Scarring: A Review of Treatment Options

    OpenAIRE

    Hession, Meghan T.; Graber, Emmy M.

    2015-01-01

    Background: Scarring is an unfortunate and frequent complication of acne, resulting in significant psychological distress for patients. Fortunately, numerous treatment options exist for acne scarring. Objectives: To extensively review the literature on treatment options for atrophic acne scarring. Materials and methods: A comprehensive literature search was conducted on the following topics: dermabrasion, subcision, punch techniques, chemical peels, tissue augmentation, and lasers. Results: T...

  12. Hyaluronidase in Clinical Isolates of Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    Harmony Tyner

    2015-01-01

    Full Text Available Objectives. We sought to describe the prevalence of a hyaluronidase gene and hyaluronidase production in 197 clinical isolates of P. acnes; we assessed kinetics of hyaluronidase production in a subset of three isolates. Methods. The hyaluronidase gene was detected using polymerase chain reaction. Hyaluronidase production was detected by growing isolates on BHI agar containing 400 μg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyaluronic acid, with a zone of clearing representing a positive phenotype. Hyaluronidase production kinetics were measured as a function of hyaluronic acid digestion over time in a liquid medium. Results. A hyaluronidase gene and hyaluronidase production were detected in 100 and 97% of P. acnes isolates, respectively. Hyaluronidase production in liquid medium was detectable after 96 hours of growth. Conclusions. Hyaluronidase production is nearly universal among P. acnes isolates. Three days appear to be required for significant hyaluronidase production in a liquid medium. Detection of hyaluronidase in tissue specimens may be a strategy to differentiate P. acnes infection from colonization when P. acnes is isolated from a clinical specimen.

  13. Environmental pollution and acne: Chloracne

    Science.gov (United States)

    Zouboulis, Christos C; Xia, Longqing

    2009-01-01

    Environmental pollutants can result in a variant of acne called ‘chloracne’. Chloracne is caused by systemic exposure to certain halogenated aromatic hydrocarbons ‘chloracnegens’, and is considered to be one of the most sensitive indicators of systemic poisoning by these compounds. Dioxin is the most potent environmental chloracnegen. Most cases of chloracne have resulted from occupational and non-occupational exposures, non-occupational chloracne mainly resulted from contaminated industrial wastes and contaminated food products. Non-inflammatory comedones and straw-colored cysts are the primary clinical manifestation of chloracne. Increasing of cysts in number is a signal of aggravation of chloracne. Generalized lesions can appear on the face, neck, trunk, exterimities, genitalia, axillary and other areas. Course of chloracne is chronic. Severity of chloracne is related to dosage of exposed chloracnegens, chloracnegenic potency and individual susceptibility. Histopathology of chloracne is characterized mainly by hyperplasia of epidermal cell, while follicular and sebaceous gland are taken placed by keratinized epidermal cell. The pathogenesis of chloracne maybe related to the imbalance of epidermal stem cell. Chloracne appears to be resistant to all tested forms of treatment. The only way to control chloracne is to prevent exposure to chloracnegens. PMID:20436879

  14. Fraxelated radiofrequency device for acne scars

    Science.gov (United States)

    Rao, Babar K.; Khokher, Sairah

    2012-09-01

    Acne scars can be improved with various treatments such as topical creams, chemical peels, dermal fillers, microdermabrasion, laser, and radiofrequency devices. Some of these treatments especially lasers and deep chemical peels can have significant side effects such as post inflammatory hyperpigmentation in darker skin types. Fraxelated RF Laser devices have been reported to have lower incidence of side effects in all skin phototypes. Nine patients between ages 18 and 35 of various skin phototypes were selected from a private practice and treated with a RF fraxelated device (E-matrix) for acne scars. Outcomes were measured by physician observation, subjective feedback received by patients, and comparison of before and after photographs. In this small group of patients with various skin phototypes, fraxelated radiofrequency device improved acne scars with minimal side effects and downtime.

  15. Evaluation of the association between acne and smoking: systematic review and meta-analysis of cross-sectional studies

    Directory of Open Access Journals (Sweden)

    Alice Mannocci

    2010-09-01

    Full Text Available

    Background: Acne vulgaris is one of the most common skin diseases with a multifactorial pathogenesis. Examination of the literature regarding the contribution of smoking to acne shows contradictory results. The aim of this study was to undertake a systematic review of the literature and meta-analysis about the association between acne and smoking.

    Methods: A systematic review and meta-analysis, when possible were performed. The literature review was based on Pubmed, Scopus and Google Scholar searches using the keywords “(smoking OR tobacco OR nicotine OR cigarettes AND acne”. Only cross-sectional studies were included. Meta-analyses were performed using the RevMan software version 5 for Windows. Four different meta-analyses were carried out: one evaluating the association between smoking habit and acne, one including data stratified by gender, one for studies with a quality score > 6, and one relating to acne classification.

    Results: Six studies were selected. The first meta-analysis, including all studies, showed a non significant role of smoke in the development of acne: OR 1.05 (95% CI: 0.66–1.67 with random effect estimate. The second meta-analyses, including data stratified by gender, showed a OR=0.99 (95% CI: 0.57–1.73 for males and a OR of 1.45 (95% CI: 0.08–24.64 for females, using random effect for the heterogeneity in both cases. The third meta-analysis, included studies with a quality score >6 resulted in an estimated OR= 0.69 (95% CI: 0.55–0.85: in this case it was possible to use the fixed effect estimate. The last meta-analysis, concerning the severity grading, showed a non-significant result: OR=1.09 (95% CI: 0.61–1.95 using the random effect approach.

    Conclusions: The first two meta-analyses found no signification association between smoking and

  16. COMPARATIVE STUDY OF CLINICAL EFFICACY AND SIDE EFFECTS OF ADAPALENE 0.1% GEL AND BENZOYL PEROXIDE 2.5% GEL AS MONOTHERAPIES AND COMBINATION THERAPY IN FACIAL ACNE: INDIAN PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Adarsh

    2014-04-01

    Full Text Available A fixed dose combination gel with adapalene 0.1% and benzoyl peroxide 2.5% has been developed for the once daily treatment of acne vulgaris .This fixed combination was approved by U.S FDA in December 2008. This study was done in the Department of Dermatology, KIMS, Bangalore to assess the efficacy and adverse effects of topical adapalene 0.1%–benzoyl peroxide 2.5% combination gel as compared to topical adapalene 0.1% gel and 2.5% benzoyl peroxide gel (monotherapies in the treatment of facial acne vulgaris. To the best of our knowledge, this is one of the few studies conducted in India. It was an open label study. Participants received either adapalene 0.1% gel, benzoyl peroxide 2.5% gel or adapalene 0.1% – benzoyl peroxide 2.5% combination gel for 12 weeks. Follow up was done at the end of 1,2,4,8 and 12 weeks. Evaluation included lesion count and adverse events. Participants included males and females aged between 18-38 years with grade 2 or 3 facial acne vulgaris as per investigators global assessment of acne scale. A total of 62 participants were recruited out of which 23 were males and 39 were females.88.71% participants completed the study. The study revealed that combination of adapalene 0.1% and benzoyl peroxide 2.5% gel was more effective in the treatment of facial acne as compared to adapalene 0.1% gel and benzoyl peroxide 2.5% gel (topical monotherapies. The safety of combination of adapalene 0.1% and benzoyl peroxide 2.5% gel was comparable with adapalene 0.1% gel and benzoyl peroxide 2.5% gel monotherapies.

  17. Therapeutic considerations for severe nodular acne.

    Science.gov (United States)

    Newman, Marissa D; Bowe, Whitney P; Heughebaert, Carol; Shalita, Alan R

    2011-02-01

    Severe nodular acne, defined as grade 4 or 5 acne on the Investigator's Static Global Assessment scale, is a skin condition characterized by intense erythema, inflammation, nodules, cysts, and scarring. Both the well known risk of physical scarring and the more recent recognition that acne can be a chronic, psychologically distressing disease with significant adverse effects on a patient's quality of life, have prompted earlier, more aggressive treatment with more effective medications, in the hope of preventing progression to more severe, nodular forms of the disease. Oral antibacterials, primarily tetracyclines, have long been the first-line therapy for severe nodular acne, which frequently remained refractory to therapy. However, concerns of antibacterial adverse effects, patient adherence, and antimicrobial resistance prompted the search for alternate therapies and combinations thereof in order to target the multifactorial pathogenesis of the disease. Isotretinoin, an oral retinoid introduced in 1982, has since become the gold standard therapy in severe acne and has revolutionized its treatment. Several adjunctive agents exist. Oral antibacterials are indicated as an alternative for patients with severe acne who cannot tolerate oral retinoids, or for whom a contraindication exists. In order to prevent bacterial resistance, antibacterials should always be used in combination with benzoyl peroxide, a nonantibiotic antimicrobial agent with anti-inflammatory activity. Topical retinoids are often added to this regimen. In women, hormonal agents, which include oral contraceptives, spironolactone, and oral corticosteroids, and, in Europe, cyproterone acetate, may be used as monotherapy or concomitantly with isotretinoin. For rapid treatment of inflammatory nodules, intralesional corticosteroids are effective. These treatment modalities have been studied, refined, and combined in novel ways in order to target the multifactorial pathogenesis of the disease, and in this

  18. Comparative evaluation of retinoic acid, benzoyl peroxide and erythromycin lotion in acne vulgarils

    Directory of Open Access Journals (Sweden)

    Dogra A

    1993-01-01

    Full Text Available Ninety three patients suffering from acne vulgaris were treated with 0.05% retinoic acid (23 patients, 10% benzyoyl peroxide (24 patients, 2% erythromycin lotin (25 patients and 50% glycerine in methylated spirit (21 patients used as a control, for a period of 6 weeks. The patients were evaluated at 2 weeks and 6 weeks by spot counting of the lesions and diagrammatic representations. Good to excellent results were obtained in 69.6% of patients of erythromycin lotion. Retinoic acid was more effective in reducing noninflammatory lesions (75.2% whereas inflammatory lesions showed better response (73.6% with erythromycin lotion and benzoyl peroxide was almost equally effective in both types of lesions.

  19. Antiandrogen and hormonal treatment of acne.

    Science.gov (United States)

    Shaw, J C

    1996-10-01

    In the treatment of acne in women, the use of antiandrogens and other hormonal approaches is a valuable alternative to standard therapy. These treatments that are based on physiologically sound principles produce gratifying results in selected women with acne, and are the primary treatment for women with hirsutism. The drugs discussed in this article include spironolactone, cyproterone acetate, flutamide, oral contraceptives, corticosteroids, finasteride, and gonadotropin-releasing hormone agonists. Patient selection, pretreatment evaluation, and case studies also are discussed with an emphasis on practical applications. PMID:9238337

  20. [How I treat... acne by isotretinoin].

    Science.gov (United States)

    Piérard-Franchimont, C; Nikkels, A F; Piérard, G E

    2008-03-01

    Acne benefits from a series of treatments. The introduction of isotretinoin was a therapeutic breakthrough which considerably improved both the evolution and the prognosis of the disease. Indications of this retinoid kept changing over the past twenty years. New clinical conditions emerged including the management of disease recurrences. The daily dosages must be selected according to the type of acne, the gender of the patient and the pharmaco-economical implications. Teratogenicity must never be neglected as it represents the dreadful adverse event of the drug. A European Directive currently marks out the way to use this retinoid. PMID:18561765

  1. Light-based therapies in acne treatment

    Directory of Open Access Journals (Sweden)

    Susan Pei

    2015-01-01

    Full Text Available The use of light and laser in the treatment of acne is increasing as these modalities are safe, effective, and associated with no or minimal complications when used appropriately. These light and laser sources are also being used in combination with pharmacological and/or physical measures to synergize their effects and optimize the therapeutic outcome. This review focuses on optical devices used in treating acne and serves to delineate the current application of various methods, including their utility and efficacy.

  2. Fluorescence guided evaluation of photodynamic therapy as acne treatment

    Science.gov (United States)

    Ericson, Marica B.; Horfelt, Camilla; Cheng, Elaine; Larsson, Frida; Larko, Olle; Wennberg, Ann-Marie

    2005-08-01

    Photodynamic therapy (PDT) is an attractive alternative treatment for patients with acne because of its efficiency and few side effects. Propionibacterium acnes (P.acnes) are bacteria present in the skin, which produce endogenous porphyrins that act as photosensitisers. In addition, application of aminolaevulinic acid or its methyl ester (mALA) results in increased accumulation of porphyrins in the pilosebaceous units. This makes it possible to treat acne with PDT. This initial study investigates the possibility of fluorescence imaging as assessment tool in adjunct to PDT of patients with acne. Twenty-four patients with acne on the cheeks have been treated with PDT with and without mALA. Fluorescence images have been obtained before and after treatment. The clinical acne score was assessed as base line before PDT, and at every follow up visit. Additionally the amount of P.acnes was determined. The clinical evaluation showed a general improvement of acne, even though no difference between treatment with and without mALA was observed. By performing texture analysis and multivariate data analsysis on the fluorescence images, the extracted texture features were found to correlate with the corresponding clinical assessment (67%) and amount of P.acnes (72%). The analysis showed that features describing the highly fluorescent pores could be related to the clinical assessment. This result suggests that fluorescence imaging can be used as an objective assessment of acne, but further improvement of the technique is possible, for example by including colour images.

  3. Sociodemographic Characteristics of Acne among University Students in Damascus, Syria

    Directory of Open Access Journals (Sweden)

    Waqar Al-Kubaisy

    2014-01-01

    Full Text Available To estimate the prevalence and identify risk factors that may be associated with acne among university students in Syria, a cross-sectional study was conducted in the Syrian International University for Science and Technology in December 2009. A sample of 500 students was chosen. Each participant was subjected to an interview and clinical examination of acne in addition to height and weight measurements. Acne prevalence was 34.7% (172/496. Male students had higher rate of acne compared to females (42.9% versus 23.6%, P<0.0001 and their acne started significantly at a younger age (18.13 versus 19.04 years old, P<0.0001. Face was the commonest site for acne in both males and females. Washing face frequently per day in both sexes has a significant relation with a decreased prevalence of acne. Moreover, psychological stress particularly when the students were away from family was associated with a significant higher rate of acne. We found that the prevalence of acne steadily increased with increasing body mass index. Acne is a health and psychological problem among university students particularly when affecting the face. Several factors such as gender, body mass index, and stress were found to be associated with acne formation.

  4. Lung and lupus vulgaris.

    Science.gov (United States)

    Mukta, V; Jayachandran, K

    2011-04-01

    Lupus vulgaris is chronic, postprimary, paucibacillary cutaneous tuberculosis found in individuals with moderate immunity and high degree of tuberculin sensitivity. Eighty percent of the lesions are on the head and neck. We present the case of a 38 year old lady who was admitted with complaints of worsening breathlessness and low grade fever of one month duration. Examination showed multiple, nontender skin ulcers on bilateral lumbar areas, two oozing serosanguinous discharge and others scarred in the centre. Respiratory system examination and chest X-ray revealed right sided pleural effusion. On investigation, pleural fluid was tuberculous in nature. Skin biopsy from the edge of ulcer was also suggestive of tuberculosis. Patient is doing well on antituberculous drugs. This case highlights the importance of cutaneous manifestations of systemic disease and is an example of the unusual presentation of lupus vulgaris in a case of pleural effusion.

  5. Strongylus vulgaris and colic

    DEFF Research Database (Denmark)

    Nielsen, Martin Krarup; Jacobsen, Stine; Olsen, Susanne Nautrup;

    , warmblooded, coldblooded), age, gender, and admitted in the same month and year, but for problems unrelated to the gastrointestinal tract. Serum samples were analyzed for antibodies to migrating S. vulgaris larvae using a recently developed ELISA. Three case definitions were used; colic sensu latum (n=274...... result should be interpreted as exposure to the parasite within the preceding five months. Nonetheless, the ELISA may be helpful in evaluating the more severe colic categories involving infarctions in the abdominal cavity....

  6. Effect of systemic isotretinoin treatment on laboratory variables in patients with acne and a review of the literature

    Directory of Open Access Journals (Sweden)

    Haydar Uçak

    2014-09-01

    Full Text Available Objective: Isotretinoin (ISO is a synthetic retinoid that is a preferred drug for unresponsive to conventional therapy in the treatment of severe cystic acne. In this study, to evaluate retrospectively laboratory values in patients with acne using oral ISO treatment was aimed. Methods: 40 patients were enrolled to the study that admitted to the dermatology clinic and clinically diagnosed as acne vulgaris and oral isotretinoin treatment was started. Patient’s retreatment and 3rd month of the teatment values of liver function tests (AST, ALT, blood urea nitrogen and creatinine levels, total cholesterol, high density lipoprotein (HDL, low density lipoprotein (LDL and triglyceride (TG levels were obtained by screening of files. Results:Compared to values of patients before and 3rd month of treatment, statistically significant differences was detected for total cholesterol, LDL, HDL, TG and AST values (p<0.001, p<0.001, p= 0.003, p= 0.01, p=0.001 respectively. Conclusion: We think that starting a good diet before treatment would be useful to prevent TG disorder. In addition, we believe it would be useful to do strict laboratory follow in patients with familial hypertriglyceridemia during treatment. We believe that it is more necessary to follow up the blood lipid values rather than liver and kidney function tests. However, we also think that it would be sufficient to follow up once every 2 or 3 months.

  7. Make-up improves the quality of life of acne patients without aggravating acne eruptions during treatments.

    Science.gov (United States)

    Hayashi, Nobukazu; Imori, Mizuho; Yanagisawa, Midori; Seto, Yoko; Nagata, Osamu; Kawashima, Makoto

    2005-01-01

    Boehncke et al. suggested that decorative cosmetics can improve the quality of life (QOL) of skin diseases. But dermatologists sometimes discourage female acne patients from applying make-up since decorative cosmetics are considered one of the aggravating factors for acne eruptions. The purpose of this study is to assess whether make-up application interferes with acne treatments and how QOL changes when the make-up items are designed for acne patients and used in order to disguise acne eruptions. Eighteen female acne patients were trained by a make-up artist and advised to apply acne-designed basic and decorative cosmetics for 2 to 4 weeks while their acne was appropriately treated. The acne-severity and QOL of patients were assessed before and after the study. The results revealed that the number of acne eruptions decreased even though patients were applying make-up. The QOL scores of Skindex-16, GHQ30 and anxiety state index greatly improved. Our results suggest that dermatologists should encourage acne patients to utilize appropriate make-up to improve their QOL. PMID:16048760

  8. Acne Etiology and Treatments in Traditional Persian Medicine

    Science.gov (United States)

    Shirbeigi, Leila; Oveidzadeh, Laleh; Jafari, Zahra; Fard, Monireh Sadat Motahari

    2016-01-01

    Background: Traditional Persian medicine (TPM) is based on humors theory. Temperament or mizaj is the result of a combination of four fundamental humors called blood, phlegm, yellow bile, and black bile. Like any other diseases, acne is the result of humoral imbalance. Acne is a highly prevalent dermatological problem, which has both physical and psychological effects on patients. The aim of this study was to determine the etiology of acne formation and natural remedies from the perspective of Persian scientists. Methods: The etiology and treatment of acne were collected and analyzed from selected TPM medical textbooks. Some selected plants in these books were assessed in tabular format and their anti-acne activities were compared with modern medicine’s databases. Results: In the acne treatment, considering six essential schemes for health, diet and herbal remedies as well as manipulation are recommended. Although the mentioned herbs in acne treatment have antibacterial, anti-inflammatory, and antioxidant effects; however, some have special proven effects on the acne formation process. There is also a strong relationship between the digestive system and skin. This paper was rendered to show ancient Persian scholar’s viewpoints on acne and its treatment. Conclusion: Some reported remedies might be beneficial towards further studies on acne treatment. PMID:26722141

  9. Deciphering the Intracellular Fate of Propionibacterium acnes in Macrophages

    Directory of Open Access Journals (Sweden)

    Natalie Fischer

    2013-01-01

    Full Text Available Propionibacterium acnes is a Gram-positive bacterium that colonizes various niches of the human body, particularly the sebaceous follicles of the skin. Over the last years a role of this common skin bacterium as an opportunistic pathogen has been explored. Persistence of P. acnes in host tissue has been associated with chronic inflammation and disease development, for example, in prostate pathologies. This study investigated the intracellular fate of P. acnes in macrophages after phagocytosis. In a mouse model of P. acnes-induced chronic prostatic inflammation, the bacterium could be detected in prostate-infiltrating macrophages at 2 weeks postinfection. Further studies performed in the human macrophage cell line THP-1 revealed intracellular survival and persistence of P. acnes but no intracellular replication or escape from the host cell. Confocal analyses of phagosome acidification and maturation were performed. Acidification of P. acnes-containing phagosomes was observed at 6 h postinfection but then lost again, indicative of cytosolic escape of P. acnes or intraphagosomal pH neutralization. No colocalization with the lysosomal markers LAMP1 and cathepsin D was observed, implying that the P. acnes-containing phagosome does not fuse with lysosomes. Our findings give first insights into the intracellular fate of P. acnes; its persistency is likely to be important for the development of P. acnes-associated inflammatory diseases.

  10. Thymus vulgaris subsp. mansanetianus subsp. nov. (Lamiaceae)

    OpenAIRE

    Pedro Pablo Ferrer-Gallego; Albert J. Navarro Peris; Emilio Laguna Lumbreras; Gonzalo Mateo Sanz

    2013-01-01

    RESUMEN: Se describe una nueva subespecie de Thymus vulgaris L. (Lamiaceae); Th. vulgaris subsp. mansanetianus subsp. nov., caracterizada por presentar un hábito postrado, tallos estoloníferos, decumbentes y radicantes, hojas muy estrechas y una floración otoñal. ABSTRACT: Thymus vulgaris subsp. mansanetianus subsp. nov. (Lamiaceae). A new subspecies of Thymus vulgaris L. (Lamiaceae); Th. vulgaris subsp. mansanetianus subsp. nov. is described. This new subspecies is characterized by its prost...

  11. A Honey Trap for the Treatment of Acne: Manipulating the Follicular Microenvironment to Control Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    E. Anne Eady

    2013-01-01

    Full Text Available Today, as 40 years ago, we still rely on a limited number of antibiotics and benzoyl peroxide to treat inflammatory acne. An alternative way of suppressing the growth of Propionibacterium acnes is to target the environment in which it thrives. We conjecture that P. acnes colonises a relatively “extreme” habitat especially in relation to the availability of water and possibly related factors such as ionic strength and osmolarity. We hypothesise that the limiting “nutrient” within pilosebaceous follicles is water since native sebum as secreted by the sebaceous gland contains none. An aqueous component must be available within colonised follicles, and water may be a major factor determining which follicles can sustain microbial populations. One way of preventing microbial growth is to reduce the water activity ( of this component with a biocompatible solute of very high water solubility. For the method to work effectively, the solute must be small, easily diffusible, and minimally soluble in sebaceous lipids. Xylose and sucrose, which fulfil these criteria, are nonfermentable by P. acnes and have been used to reduce water activity and hence bacterial colonisation of wounds. A new follicularly targeted topical treatment for acne based on this approach should be well tolerated and highly effective.

  12. Role of insulin resistance and diet in acne

    OpenAIRE

    Rashmi Kumari; Devinder Mohan Thappa

    2013-01-01

    There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of vario...

  13. The use of hormonal agents in the treatment of acne.

    Science.gov (United States)

    Hassoun, Lauren A; Chahal, Dev S; Sivamani, Raja K; Larsen, Larissa N

    2016-06-01

    Hormones and androgens play an important role in the pathogenesis of acne. Multiple hormonal modulators are now available for the treatment of acne. The efficacies and side effects of currently available hormonal agents are reviewed here including the use of oral contraceptives, spironolactone, flutamide, cyproterone acetate, finasteride, and cortexolone 17α-propionate. Hormonal therapies are an efficacious treatment option for acne among females. With the growing need to reduce antibiotic exposures, hormonal therapies should be more widely studied and incorporated into acne treatment strategies. PMID:27416311

  14. Practical approach to the hormonal treatment of acne.

    Science.gov (United States)

    Poulin, Yves

    2004-01-01

    Acne is a disease of the pilosebaceous units and these are mainly under hormonal control. In female patients, hormonal therapy is a unique opportunity for the treatment of acne. Several combined oral contraceptives (COCs), cyproterone acetate, spironolactone, flutamide, and others, have been tried for the control of acne. An overview on the use of the most useful drugs in clinical practice was conducted. COCs are thoroughly discussed, also taking into consideration their potential side effects. A practical approach with guidelines on the use of COC in acne is proposed. PMID:15778820

  15. Role of insulin resistance and diet in acne.

    Science.gov (United States)

    Kumari, Rashmi; Thappa, Devinder Mohan

    2013-01-01

    There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne. PMID:23619434

  16. Diet and acne update: carbohydrates emerge as the main culprit.

    Science.gov (United States)

    Mahmood, Shereen N; Bowe, Whitney P

    2014-04-01

    The prevalence of adult acne in the US appears to be increasing over the last few decades. But what's behind the rise: is it nature or nurture? We are well aware that genetics can strongly influence a patient's risk of developing acne. However, significant changes in germline genetic variants are unlikely to have occurred over the last 20 years. Consequently, we are forced to examine environmental variables, including diet. This review article presents the most updated evidence supporting a link between refined carbohydrates and acne. Based on the data summarized here, dermatologists should encourage their acne patients to minimize their intake of high glycemic index foods. PMID:24719062

  17. Role of insulin resistance and diet in acne

    Directory of Open Access Journals (Sweden)

    Rashmi Kumari

    2013-01-01

    Full Text Available There is increasing evidence in support of the interplay of growth hormone (GH, insulin, and insulin-like growth factor-1 (IGF-1 signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.

  18. Hirsutism and acne in polycystic ovary syndrome.

    Science.gov (United States)

    Archer, Johanna S; Chang, R Jeffrey

    2004-10-01

    Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality affecting reproductive age women. Population-based studies estimate a prevalence of 5-10% [Obstet Gynecol 101 (2003) 995; Aust N Z J Obstet Gynaecol 41 (2001) 202]. The clinical characteristics of PCOS include hyperandrogenism, chronic anovulation, insulin resistance and infertility. Hyperandrogenism is generally manifested as hirsutism and acne. Both these clinical symptoms are treated with similar drug therapies, including oral contraceptive pills (OCPs), topical medications or antiandrogens such as spironolactone, flutamide and finasteride, as well as topical medications. Recent studies have shown that lower doses of these medications are as efficacious as high doses and have the advantage of decreased cost and an improved side-effect profile. Although hirsutism and acne can be considered cosmetic in nature, they cause significant social embarrassment and emotional distress. Physicians should be sensitive to these issues and approach patients in a caring and sympathetic manner. PMID:15380144

  19. Spironolactone for 
Adult Female Acne.

    Science.gov (United States)

    Friedman, Adam J

    2015-10-01

    Many cases of acne are hormonal in nature, meaning that 
they occur in adolescent girls and women and are aggravated 
by hormonal fluctuations such as those that occur during the menstrual cycle or in the setting of underlying hormonal imbalances as seen in polycystic ovary syndrome. For these patients, antihormonal therapy such as spironolactone is a valid and efficacious option. Herein, initiation and utilization of this medication is reviewed. PMID:27141564

  20. Hyaluronidase in Clinical Isolates of Propionibacterium acnes

    OpenAIRE

    Harmony Tyner; Robin Patel

    2015-01-01

    Objectives. We sought to describe the prevalence of a hyaluronidase gene and hyaluronidase production in 197 clinical isolates of P. acnes; we assessed kinetics of hyaluronidase production in a subset of three isolates. Methods. The hyaluronidase gene was detected using polymerase chain reaction. Hyaluronidase production was detected by growing isolates on BHI agar containing 400 μg/mL hyaluronic acid and 1% albumin and flooding plates with 2 N glacial acetic acid to precipitate unbound hyalu...