WorldWideScience

Sample records for acidente vascular cerebral

  1. Mixoma atrial esquerdo com acidente vascular cerebral isquêmico em criança

    Directory of Open Access Journals (Sweden)

    Takakura Isabela Thomaz

    1998-01-01

    Full Text Available É apresentado um caso de mixoma atrial esquerdo associado a acidente vascular cerebral embólico em paciente do sexo feminino, com oito anos de idade. Feita a exérese do tumor, a criança apresentava, dois meses após cirurgia, presença de massa septoatrial esquerda, sugerindo recidiva, mantendo-se, porém, assintomática. A revisão da literatura enfatiza a raridade e a agressividade com que este tumor acomete esta faixa etária, além de salientar baixas taxas de recidiva após sua retirada.

  2. Acidente vascular cerebral ou doença encéfalo vascular ?: Revendo a designação e respeitando a anatomia

    Directory of Open Access Journals (Sweden)

    João Eliézer Ferri-de-Barros

    1994-06-01

    Full Text Available Desde que a doença vascular que acomete o sistema nervoso central de localização intracraniana pode comprometer estruturas supra ou/e infratentoriais, propomos a mudança de "Acidente vascular cerebral" para "Doença encéfalo vascular".

  3. Avaliação da linguagem após acidente vascular cerebral em adultos no estado de Sergipe

    Directory of Open Access Journals (Sweden)

    João Sigefredo Arruda

    2014-06-01

    Full Text Available Objetivo analisar a ocorrência de distúrbios de linguagem nos indivíduos que sofreram Acidente Vascular Cerebral. Métodos foi avaliada a linguagem de todos os pacientes acometidos por Acidente Vascular Cerebral, atendidos de fevereiro a agosto de 2012, no setor de fisioterapia de centro de referência em educação e saúde do Estado de Sergipe. A avaliação foi baseada no Teste do Rio de Janeiro (2005. A análise dos dados foi realizada por meio de estatística descritiva e probabilística através da distribuição de frequência, cálculos da média, desvio padrão e percentis, do Teste U de Mann-Whitney e Qui-Quadrado. Resultado foram encontrados 31 indivíduos, de ambos os gêneros, com idade variando de 30 a 94 anos. Foi evidenciado que as variáveis: gênero, escolaridade e idade, influenciam no desempenho do teste, verificando-se que o gênero masculino, sujeitos abaixo de 65 anos e os com escolaridade acima de fundamental incompleto pontuam mais. Conclusão maior percentual da amostra apresenta mais alteração na compreensão do que na expressão.

  4. Predictive factors for spasticity among ischemic stroke patients Fatores preditivos para espasticidade após acidente vascular cerebral

    Directory of Open Access Journals (Sweden)

    Rita de Cássia dos Reis Moura

    2009-12-01

    Full Text Available Spasticity is a determining for functional loss following ischemic stroke. OBJECTIVE: To detect possible predictive factors for its occurrence. METHOD: Demographic, clinical and tomographic data on 146 stroke patients were analyzed. RESULTS: Spasticity was noted more frequently among patients who underwent physiotherapy (pA espasticidade é fator determinante para perda funcional após o acidente vascular cerebral isquêmico (AVCI. OBJETIVO: Detectar possíveis fatores preditivos para a ocorrência da espasticidade. MÉTODO: Foram analisados dados demográficos, clínicos e tomográficos de 146 pacientes pós-AVCI. RESULTADOS: Na análise univariada a espasticidade foi notada com maior freqüência em pacientes que realizaram fisioterapia (p<0,0001; OR=19,4; 95% CI: 4,4-84,5, com maior tempo de duração desse tratamento (p=0,028; OR=4,80; 95% CI: 1,1-8,3 e que realizavam trabalho braçal (p=0,041; OR=2,2; 95% CI: 1,02-4,6, renda menor (p=0,038, referência de dor (p<0,0001; OR=107,0; 95% CI: 13,5-847,3 e seu aparecimento simultâneo à espasticidade (p<0,0001, acidente vascular cerebral (AVC pregresso (p=0,001; OR=4,2; 95% CI: 1,7-10,3, fraqueza muscular (p<0,0001; OR=91,9; 95% CI: 12,0-699,4, lesão tomográfica extensa (p=0,01 e lesão afetando mais de um lobo cerebral (p=0,018. Na análise de regressão multivariada a atividade braçal apresentou risco relativo de 2,9; acidente vascular cerebral prévio com risco relativo de 3,9 e lesão tomográfica extensa risco relativo de 3,6. CONCLUSÃO: A espasticidade afetou um quarto da população estudada e esteve associada ao trabalho braçal, AVC pregresso, lesões tomográficas extensas, diminuição da renda individual, realização de fisioterapia, realização de fisioterapia por um período maior, presença de dor, surgimento da dor simultânea à espasticidade e alteração da força.

  5. PERFIL DA DISFAGIA APÓS UM ACIDENTE VASCULAR CEREBRAL: UMA REVISÃO INTEGRATIVA

    Directory of Open Access Journals (Sweden)

    CARINA TEIXEIRA PAIXÃO

    2010-01-01

    Full Text Available Este artículo trata de disfagia decurrente de una enfermedad vascular cerebral (EVC. El objetivo fue determinar el perfil de las publicaciones acerca de la disfagia en pacientes víctimas de EVC. Investigación de revisión integradora que usó los mismos descriptores en las bases Medline, Scielo e Lilacs, seleccionando 17 artículos entre 1998 a 2008. Los datos fueron analizados a partir de las categorías correspondientes a los enfoques de las publicaciones encontradas. Los resultados muestran diecisiete artículos agrupados en dos categorías, la que trató de la incidencia y características de la disfagia (9 y la que discutió las complicaciones de la disfagia (8. Las publicaciones de la primera categoría muestran una incidencia de la disfagia entre 30% a 91% e indican que tamaño y localización de la lesión son determinantes en la gravedad de la disfagia. La segunda categoría presenta la pulmonía y desnutrición como consecuencias de la disfagia. Se concluye que el enfermero debe guiar los cuidados direccionados a limitar el efecto de la disfagia post EVC y sus complicaciones para el paciente.

  6. Acidente vascular cerebral hemorrágico associado à acidente ofídico por serpente do gênero bothrops: relato de caso Hemorrhagic stroke related to snakebite by bothrops genus: a case report

    Directory of Open Access Journals (Sweden)

    Amanda Silva Machado

    2010-10-01

    Full Text Available Este trabalho tem como objetivo relatar um caso de acidente vascular cerebral hemorrágico, associado à acidente ofídico por serpente do gênero bothrops e hipertensão arterial sistêmica grave. Apesar do ofidismo botrópico ser frequente no Estado do Pará, tais associações são incomuns, necessitando de uma abordagem especializada e precoce, visando menores complicações.This research reports a clinical case of hemorrhagic stroke due to envenomation by bothrops snakebite associated with severe hypertension. Although bothrops snakebites are frequent in the State of Pará, such associations are uncommon, requiring specialized and early management to avoid severe complications.

  7. Neurofibromatosis, stroke and basilar impression: case report Neurofibromatose, acidente vascular cerebral e impressão basilar: relato de caso

    Directory of Open Access Journals (Sweden)

    ELCIO JULIATO PIOVESAN

    1999-06-01

    Full Text Available Neurofibromatosis type 1 (NF1 can virtually affect any organ, presenting most frequently with "cafe au lait" spots and neurofibromas. Vasculopathy is a known complication of NF1, but cerebrovascular disease is rare. We report the case of a 51-year-old man admitted to the hospital with a history of stroke four months before admission. On physical examination, he presented various "cafe au lait" spots and cutaneous neurofibromas. Neurologic examination demonstrated right-sided facial paralysis, right-sided hemiplegia, and aphasia. Computed tomography scan of head showed hypodense areas in the basal ganglia and centrum semiovale. Radiographs of cranium and cervical spine showed basilar impression. Angiography revealed complete occlusion of both vertebral and left internal carotid arteries, and partial stenosis of the right internal carotid artery. A large network of collateral vessels was present (moyamoya syndrome. It is an uncommon case of occlusive cerebrovascular disease associated with NF1, since most cases described in the literature are in young people, and tend to spare the posterior cerebral circulation. Basilar impression associated with this case may be considered a pure coincidence, but rare cases of basilar impression and NF1 have been described.A neurofibromatose tipo 1 (NF1 pode acometer qualquer órgão mas as apresentações mais frequente são manchas café com leite e neurofibromas. O envolvimento de vasos é complicação conhecida da NF1, mas a doença cerebrovascular é rara. Relatamos o caso de paciente do sexo masculino de 51 anos com história de acidente vascular cerebral há quatro meses da admissão. Ao exame físico apresentava várias manchas café com leite e neurofibromas cutâneos. O exame neurológico demonstrou acometimento facial direito, hemiplegia direita e afasia. Tomografia computadorizada de crânio mostrou áreas hipodensas nos gânglios basais e centros semi-ovais. Radiografias do crânio e coluna cervical

  8. O G-CSF na terapia do acidente vascular cerebral The potential role of G-CSF in stroke

    Directory of Open Access Journals (Sweden)

    Angelo L. Maset

    2009-05-01

    Full Text Available O fator estimulador de colônias granulocitárias (G-CSF é uma glicoproteína descrita há mais de vinte anos, e é largamente utilizada para tratamento de estados neutropênicos e no transplante de medula óssea. O G-CSF estimula células-tronco hematopoéticas e regula crucialmente a sobrevivência de neutrófilos maduros, pós-mitóticos, através da inibição da apoptose. Além do efeito sistêmico, mais recentemente tem-se demonstrado uma surpreendente atividade do G-CSF no sistema nervoso central. A administração de G-CSF mobiliza células-tronco e progenitoras da medula óssea para o sangue periférico, que, por sua vez, atravessa a barreira hemato-encefálica (BHE e se dirige à área acometida do cérebro. A atividade do G-CSF no sistema nervoso central tem sido caracterizada como multimodal, pois, além do efeito mobilizador de células da medula óssea, demonstrou uma ação direta neuroprotetora através de diferentes mecanismos, tais como a atividade antiapoptótica em neurônios, regeneração da vascularização, efeito anti-inflamatório e estimulação da neurogênese endógena. Este relato sumariza a ação do G-CSF no sistema nervoso central e aborda seu potencial para o emprego no acidente vascular cerebral.The granulocyte colony-stimulating-factor (G-CSF is a glycoproteina which has been described for decades, and it is commonly utilized in the treatment of neutropenic states and bone marrow transplants. G-CSF stimulates hematopoietic stem-cels e crucially regulates the survival of mature neutrophils through a mechanism of apoptosis inhibition. Beyond its systemic effect, recently it has been shown its surprising activity in the central nervous system (CNS. G-CSF administration mobilizes bone marrow stem cells para systemic blood, and those cells cross the blood-brain-barrier e target brain's damaged area. G-CSF's activity in the CNS has been defined as multimodal, because additionally it has been demonstrated a direct

  9. Dieta DASH na redução dos níveis de pressão arterial e prevenção do acidente vascular cerebral = DASH diet in reducing blood pressure and preventing stroke

    Directory of Open Access Journals (Sweden)

    Piper, Vanessa Alves

    2012-01-01

    Conclusões: As evidências disponíveis sugerem que modificações no estilo de vida, incluindo a adoção de uma dieta tipo DASH, são estratégias eficazes no controle da hipertensão arterial e na redução de eventos cardiovasculares, como o acidente vascular cerebral

  10. Cuidador familiar de seqüelados de acidente vascular cerebral: significado e implicações Family caregiver of stroke sequel patients: meanings and implications

    Directory of Open Access Journals (Sweden)

    Fernanda de Freitas Mendonça

    2008-01-01

    Full Text Available O acidente vascular cerebral (AVC está entre as principais causas de morte no mundo. Diante das incapacidades impostas pelo AVC, surge o cuidador familiar. O objetivo desta pesquisa foi analisar o significado e as implicações de se tornar cuidador de um indivíduo seqüelado de AVC. Trata-se de um estudo qualitativo, realizado com cinco cuidadores, em Londrina-PR, no período de agosto a dezembro de 2005. Os dados foram coletados por meio de entrevistas semi-estruturadas e submetidos à análise de discurso proposta por Martins e Bicudo. Da análise das entrevistas emergiram sete categorias: voltando-se para o Ser cuidado, descrevendo os cuidados, apresentando as mudanças, o apoio da espiritualidade, compreendendo o significado do cuidado, expressando as necessidades para cuidar e perspectivas para o futuro. Os resultados revelaram que ser cuidador familiar é um fenômeno complexo, que gera nos sujeitos sentimentos de alegria e felicidade concomitantes aos sentimentos de medo, ansiedade e revolta.The brain vascular accident (BVA is one of the main death causes worldwide. Due to the impairments imposed by the BVA, there is the family caregiver. This work aims to analyze the meaning and implications of being a caregiver of a stroke sequel person. It is a qualitative research, carried out with five caregivers in Londrina-PR, from August to December 2005. Data were collected in semi-structured interviews and were subjected to discourse analysis proposed by Martins and Bicudo. From the analysis of interviews seven categories arouse: turning to the being cared, describing care, presenting changes, spirituality support, understanding the meaning of care, expressing the needs to take care and future perspectives. Results revealed that being a family caregiver is a complex phenomenon, that creates in the subjects feelings of happiness and along with feelings of fear, anxiety and revolt.

  11. Time of presentation of stroke patients in São Paulo Hospital Tempo de chegada do paciente com acidente vascular cerebral no Hospital São Paulo

    Directory of Open Access Journals (Sweden)

    José Fábio Santos Leopoldino

    2003-06-01

    Full Text Available With the advent of time-dependent thrombolytic therapy for ischemic stroke it has become increasingly important for stroke patients to arrive at the hospital quickly. This study investigated the time that our patients took since the recognition of the symptoms until the stroke diagnosis in a hospital in the city of São Paulo. We concluded that in our hospital medical personnel and paramedics did not consider stroke as a medical emergency before neurological evaluation. Social problems as lack of access to an effective emergency medical service are another important factor that was responsible for patient's delay. Our study was important in order to identify the problems that stroke patients face in our country until the diagnosis is established.Com o uso da terapia trombolítica para acidente vascular cerebral (AVC isquêmico, torna-se importante o tempo de chegada do paciente nos serviços de referência. Neste estudo foi investigado o tempo entre o reconhecimento dos sintomas e o diagnóstico de AVC em hospital universitário na cidade de São Paulo. Concluímos que neste serviço, os profissionais da saúde não consideravam AVC uma emergência antes da avaliação neurológica. Outro fator que contribuiu para o atraso na chegada ao hospital foi dificuldade de transporte aos serviços públicos. Este estudo foi importante para a identificação dos problemas que os pacientes com AVC enfrentam para ter o diagnóstico e tratamento, o que possibilitou implantação de programas para melhora do atendimento.

  12. Estudo das freqüências dos principais fatores de risco para acidente vascular cerebral isquêmico em idosos Study of the main risk factors frequencies for ischemic cerebrovascular disease in elderly patients

    OpenAIRE

    Sueli Luciano Pires; Rubens José Gagliardi; Milton Luiz Gorzoni

    2004-01-01

    Foram estudados retrospectivamente 262 pacientes com diagnóstico clínico de acidente vascular cerebral isquêmico (AVCi) permanente, com idade igual ou superior a 60 anos, selecionados dos 1015 registros da Liga de Aterosclerose da Clínica Neurológica da ISCMSP, de 1990 a 2002. O estudo focalizou as freqüências dos fatores de risco modificáveis para AVCi nesta população idosa, considerando-se sexo e faixa etária dos pacientes. Os resultados evidenciaram que a hipertenção arterial sistêmica é s...

  13. Stroke in ancient times: a reinterpretation of Psalms 137:5,6 Acidente vascular cerebral nos velhos tempos: uma reinterpretação dos Salmos 137 (versículos 5,6

    Directory of Open Access Journals (Sweden)

    Luiz Antonio de Lima Resende

    2008-09-01

    Full Text Available Stroke was probably first described in Psalms 136: 5-6 of the Catholic Bible, and Psalms 137:5-6 of the Evangelical Bible. Based on the Portuguese, Spanish, English, German, Dutch, Russian, Greek, and original Hebrew Bible, the significance of this Psalm is the invocation of a punishment, of which the final result would be a stroke of the left middle cerebral artery, causing motor aphasia and right hemiparesis.Acidente vascular cerebral foi descrito pela primeira vez provavelmente na Bíblia, nos Salmos 136, versículos 5 e 6, da bíblia católica, e 137, versículos 5 e 6, da bíblia evangélica. Nas bíblias escritas em português, espanhol, inglês, alemão, holandês, russo, grego e no original hebraico, o significado destes Salmos seria a invocação de um castigo, que poderia corresponder a acidente vascular da artéria cerebral média esquerda, levando a afasia motora com hemiplegia direita.

  14. Aplicabilidade e segurança do nitroprussiato de sódio para controle da pressão arterial durante trombólise no tratamento do acidente vascular cerebral isquêmico agudo = Applicability and safety of sodium nitroprusside to control arterial pressure during thrombolysis in the treatment of acute ischemic stroke

    OpenAIRE

    Oliveira, Fábio Pascotto de; Klant, Charles Luiz; Friedrich, Maurício André Gheller

    2008-01-01

    Objetivos: relatar a experiência com uso do nitroprussiato de sódio na fase aguda do acidente vascular cerebral isquêmico. Métodos: um estudo retrospectivo, consistindo na revisão de prontuários, incluiu os pacientes que sofreram acidente vascular cerebral isquêmico e foram trombolisados com alteplase endovenosa, entre maio de 2005 e julho de 2007. Resultados: dos 48 pacientes que atenderam aos critérios de inclusão, 15 utilizaram nitroprussiato de sódio para controle da pressão arteria...

  15. Ischemic stroke in children: a study of the associated alterations Acidente vascular cerebral isquêmico na infância: estudo das alterações associadas

    Directory of Open Access Journals (Sweden)

    Josiane Ranzan

    2004-09-01

    Full Text Available Arterial ischemic stroke (AIS in children is a relatively rare disease, not yet clearly understood and with a multifactored etiology. It can cause a severe impact on the child and be the first manifestation of a systemic disease. Delayed diagnosis is still common and research on the subject in our field practically does not exist. Prothrombotic disorders have been described as important causative factors of the ischemic event in children. Forty-six patients from zero to 18 years of age diagnosed with AIS were studied in the period between March 2002 and September 2003. Laboratory tests were realised including coagulation proteins and echocardiogram. AIS of the newborn occurred in 37% of the cases. Focal seizures and hemiparesis were the most frequent symptoms; 40% of the patients presented prior pathologies. Abnormalities of the S and C proteins occurred in 22% and 17%. Associated alterations, particularly those that generate a hypercoagulability state, indicate more than one risk factor for this disease in childhood.Acidente vascular cerebral Isquêmico (AVCI na infância é relativamente raro, de conhecimento ainda obscuro, e com etiologia multifatorial. Pode causar grave impacto na criança e ser a primeira manifestação de doença sistêmica. O subdiagnóstico ainda é comum e são praticamente inexistentes as pesquisas sobre o assunto no nosso meio. Desordens protrombóticas têm sido descritas como importantes fatores causais do evento isquêmico na infância. Foram estudados 46 pacientes de zero a 18 anos, com diagnóstico de AVCI, no período de março/2002 a setembro/2003. Exames laboratoriais, incluindo proteínas de coagulação e ecocardiograma foram realizados. AVCI neonatal ocorreu em 35% dos casos. Crise focal e hemiparesia foram os sintomas iniciais mais freqüentes; 40% dos casos apresentaram patologia prévia. Anormalidades nas proteínas S e C ocorreram em 22% e 17% da amostra. Alterações associadas, principalmente as que

  16. Cognitive improvement after treatment of depressive symptoms in the acute phase of stroke Melhora cognitiva com tratamento antidepressivo na fase aguda do acidente vascular cerebral

    Directory of Open Access Journals (Sweden)

    Samuel Simis

    2006-06-01

    Full Text Available The outcome of antidepressant treatment for depressive symptoms and cognitive impairment at the acute phase of stroke is controversial. We investigated 93 patients, treating with citalopram 36 with severe depressive symptoms (HAM-D: Hamilton Depression Rating Scale >18, whilst 19 patients with mild depressive symptoms, and 38 non-depressed patients, remained untreated. At baseline (two weeks after stroke, patients with severe depressive symptoms had lower scores in total Dementia Rating Scale (DRS and in the attention and memory DRS subscales, than the non-depressed patients (pOs resultados do tratamento com antidepressivo para os sintomas depressivos e comprometimento cognitivo da fase aguda do acidente vascular cerebral não estão estabelecidos. Investigamos 93 pacientes, 36 com sintomas depressivos graves (HAM-D: Escala de Depressão de Hamilton >18 foram tratados com citalopram, enquanto 19 pacientes com sintomas depressivos leves e 38 não-deprimidos não foram tratados. Ao início do tratamento (duas semanas depois do icto, pacientes com sintomas depressivos graves tinham escores mais baixos na Escala de Avaliação de Demência (DRS total e nas subescalas de atenção e de memória da DRS do que os pacientes não-deprimidos (p<0,001. Ao fim de três meses de acompanhamento essas diferenças tinham desaparecido, mas pacientes que inicialmente tinham sintomas depressivos leves passaram a ter escores mais altos no HAM-D do que os não-deprimidos (p=0,015, e escores mais baixos nas subescalas de atenção e memória da DRS (p<0,01 do que os pacientes tratados com citalopram. O tratamento associou-se a melhora de humor, memória e atenção, e demonstra que é necessário um estudo controlado com placebo para o tratamento de sintomas depressivos leves.

  17. Reabilitação de déficits comunicativos pós-acidente vascular cerebral Rehabilitation of post-stroke communication impairments

    Directory of Open Access Journals (Sweden)

    Gigiane Gindri

    2012-01-01

    Full Text Available Os processamentos comunicativos discursivo, léxico-semântico, pragmático-inferencial e/ou prosódico podem apresentar-se deficitários após um acidente vascular cerebral. Esses prejuízos demandam métodos e programas de intervenção para uma reabilitação efetiva da comunicação. Neste contexto, o objetivo desta revisão sistemática foi identificar e descrever métodos utilizados para reabilitação neuropsicológica da comunicação de adultos acometidos por lesão cerebrovascular, mais especificamente, abordagens sistematizadas de intervenção para cada um dos processamentos comunicativos. Foram avaliados resumos publicados nos últimos dez anos na base de dados PubMed, utilizando palavras-chave relacionadas aos construtos reabilitação, acidente vascular cerebral (AVC e comunicação. Para o construto comunicação foram utilizadas, ainda, palavras específicas dos quatro processamentos comunicativos. Inicialmente, foram encontrados 914 abstracts, dos quais, após exclusão dos repetidos, 460 foram analisados. Os critérios de inclusão de abstracts para análise de seus textos completos foram ser estudo empírico, ter a participação de pelo menos um indivíduo adulto pós-AVC, tratar de reabilitação da comunicação, apresentar intervenção para pelo menos um dos quatro processamentos comunicativos, ter avaliação pré e pós-tratamento, estar escrito em inglês, francês ou português, e ter sido publicado nos últimos dez anos. Apenas quatro artigos empíricos cumpriram tais critérios, sendo conduzidos predominantemente com adultos afásicos ou com aprosódia. Assim, tais achados podem ser considerados surpreendentes e alarmantes frente à escassez de estudos sistemáticos de reabilitação de componentes comunicativos. Ressalta-se a necessidade de descrição detalhada de procedimentos de intervenção com objetivos específicos para que estudos possam ser replicados, contribuindo também para a verificação do efeito

  18. Função vestibular no acidente vascular cerebral do território carot��deo Vestibular function in carotid territory stroke patients

    Directory of Open Access Journals (Sweden)

    Anna Paula Batista de Ávila Pires

    2013-02-01

    Full Text Available Pacientes após Acidente Vascular Cerebral (AVC podem apresentar sintomas otoneurológicos. OBJETIVO: Avaliar a função vestibular de pacientes com antecedente pessoal de AVC no território carotídeo. Desenho científico: estudo de coorte histórica com corte transversal. MÉTODO: Quarenta pacientes foram submetidos à anamnese, exame otorrinolaringológico, Dizziness Handicap Inventory e vectoeletronistagmografia. RESULTADOS: Anormalidades discretas dos movimentos sacádicos foram encontradas em 20 pacientes (50,0%; nove referiram desequilíbrio e um tontura. O ganho do rastreio pendular foi anormal em 17 casos (42,5%; seis referiram desequilíbrio e um tontura. Preponderância direcional anormal do nistagmoperrotatório ocorreu em dois casos (5,0%, que referiram desequilíbrio. A prova calórica identificou três casos (7,5% com predomínio labiríntico anormal e dois (5,0% com preponderância direcional anormal do nistagmo; os cinco casos relataram desequilíbrio. Dos 11 pacientes que não referiram manifestações de alteração do equilíbrio corporal, 10 apresentaram alterações nos movimentos sacádicos e no rastreio pendular e um apresentou exame vestibular normal. CONCLUSÃO: Pacientes com antecedente pessoal de AVC no território carotídeo podem apresentar tontura ou desequilíbrio corporal e sinais de comprometimento da motilidade ocular e da função vestibular.Stroke patients may present otoneurological symptoms. OBJECTIVE: To assess the vestibular function of subjects with a history of carotid territory stroke. METHOD: This historical cohort cross sectional study enrolled 40 patients; subjects answered the Dizziness Handicap Inventory, were interviewed and submitted to ENT examination and vectorelectronystagmography. RESULTS: Mild saccadic movement anomalies were seen in 20 patients (50.0%; nine complained of imbalance and dizziness. Abnormal smooth pursuit gain was seen in 17 cases (42.5%; six subjects reported imbalance and

  19. Sobrecarga dos cuidadores de idosos com acidente vascular cerebral Sobrecarga de los cuidadores de ancianos con accidente cerebrovascular Burden on caregivers of elderly victims of cerebrovascular accident

    Directory of Open Access Journals (Sweden)

    Roberta Amorim Pereira

    2013-02-01

    Full Text Available O objetivo deste estudo foi avaliar a sobrecarga dos cuidadores de idosos com acidente vascular cerebral (AVC, assim como correlacioná-la com as horas de cuidado, a idade e a independência funcional dos idosos. Trata-se de estudo transversal feito com 62 idosos com AVC e seus cuidadores. O instrumento continha variáveis sociodemográficas e econômicas, Mini-Exame do Estado Mental, Medida da Independência Funcional (MIF e a Escala de Zarit. A possível correlação entre os escores da escala de Zarit e as outras variáveis foi avaliada por meio do Coeficiente de Correlação de Pearson. A maioria dos cuidadores era adultos, filhos, casados e do sexo feminino. A média do escore de Zarit foi 34,92 (15,8. A MIF apresentou correlação negativa com a sobrecarga do cuidador, porém, não houve correlação com a idade e as horas de cuidado. A sobrecarga da maioria dos cuidadores variou de moderada a severa e parece estar relacionada ao nível de independência funcional dos idosos.Se objetivó evaluar la sobrecarga de cuidadores de ancianos con accidente cerebrovascular (ACV, y correlacionarla con horas de cuidado, edad e independencia funcional de los ancianos. Estudio transversal con 62 ancianos con ACV y sus cuidadores. El instrumento contenía variables sociodemográficas y económicas, Mini-Examen del Estado Mental, Medida de la Independencia Funcional (MIF y la Escala de Zarit. La posible correlación entre los puntajes de la escala de Zarit y las otras variables fue evaluada por Coeficiente de Correlación de Pearson. La mayoría de los cuidadores eran adultos, hijos, casados y de sexo femenino. El promedio de puntaje de Zarit fue 34,92 (15,8. La MIF presentó correlación negativa con la sobrecarga del cuidador, sin embargo no hubo correlación con edad y horas de cuidado. La sobrecarga de la mayoría de los cuidadores varió entre moderada y severa, y parece relacionarse con el nivel de independencia funcional del anciano.The aim was to

  20. Perfil do cuidador familiar do paciente com seqüela de acidente vascular encefálico Profile of the family caregiver caring for patients with sequels of cerebral vascular accident

    OpenAIRE

    Natália da Rosa Fonseca; Aline Fonseca Gueudeville Penna

    2008-01-01

    Este estudo descritivo, por meio de uma abordagem qualitativa, teve como objetivo conhecer quem são os cuidadores familiares e entender como se dá a escolha do cuidador dentro da família de pacientes com seqüela de acidente vascular encefálico. Participaram do estudo dez cuidadores familiares através de entrevistas e anotações de campo. As entrevistas foram gravadas e posteriormente transcritas e analisadas. Entre os entrevistados, predominaram as mulheres, casadas, cônjuges e filhos, com méd...

  1. Imaging findings and cerebral perfusion in arterial ischemic stroke due to transient cerebral arteriopathy in children; Achados de imagem e perfusao arterial cerebral em acidente vascular cerebral isquemico devido a arteriopatia transitoria em crianca

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa Junior, Alcino Alves, E-mail: alcinojr@uol.com.br [Departamento de Diagnostico por Imagem, Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP (Brazil); Ellovitch, Saada Resende de Souza [Neuropediatria, Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP (Brazil); Pincerato, Rita de Cassia Maciel [Hospital Samaritano, Sao Paulo, SP (Brazil)

    2012-04-15

    We report the case of a 4-year-old female child who developed an arterial ischemic stroke in the left middle cerebral artery territory, due to a proximal stenosis of the supraclinoid internal carotid artery, most probably related to transient cerebral arteriopathy of childhood. Computed tomography scan, magnetic resonance imaging, perfusion magnetic resonance and magnetic resonance angiography are presented, as well as follow-up by magnetic resonance and magnetic resonance angiography exams. Changes in cerebral perfusion and diffusion-perfusion mismatch call attention. As far as we know, this is the first report of magnetic resonance perfusion findings in transient cerebral arteriopathy. (author)

  2. Emergency physician's diagnosis of stroke subtype: an accuracy study Diagnóstico dos subtipos de acidente vascular cerebral: um estudo de acurácia com médicos de emergência

    Directory of Open Access Journals (Sweden)

    MARLEIDE DA MOTA GOMES

    1998-09-01

    Full Text Available OBJECTIVE: To evaluate the accuracy of clinical unstructured and structured diagnosis of acute stroke subtypes -- cerebral haemorrhage (CH, cerebral infarction (CI, subarachnoid haemorrhage (SAH. METHODS: Sixty consecutive patients with acute stroke admitted to the Emergency Ward of a Brazilian University Hospital were examined by emergency physicians and computerised tomography (CT. We also compared it (physician's unstructured diagnosis to two published clinical scoring systems (structured diagnosis - Guy's Hospital and Siriraj Hospital applied to three other populations -- regarding the operational characteristics of the tests. RESULTS: In our personal data, among 9 variables that could discriminate CH and CI, three have statistically significant difference (p OBJETIVO: Avaliar a acurácia do diagnóstico clínico não estruturado e do estruturado dos subtipos do acidente vascular cerebral (AVC: hemorragia cerebral (HC, infarto cerebral (IC, hemorragia subaracnóide (HSA. MÉTODO: Sessenta pacientes com AVC consecutivamente admitidos em emergência de hospital universitário brasileiro foram examinados por médicos da emergência e por tomografia computadorizada (TC. Nós também comparamos isso (diagnóstico clínico não estruturado com os resultados de dois testes diagnósticos estruturados sobre AVC da literatura (Guy's Hospital e Siriraj Hospital aplicados a três outras populações -- com atenção às características operacionais dos testes. RESULTADOS: Em nossos dados pessoais, entre nove variáveis que poderiam discriminar HC e IC, três apresentaram diferenças significantes estatisticamente (p<0.05: cefaléia (p=0.0002 e vômito (p=0.02 ocorreram mais frequentemente naqueles com HC, mas AVC prévio naqueles com IC (p=0.04. Diagnóstico não estruturado mostrou-se válido para HSA, com +LHR= 39.7; e em menor grau para IC (-LHR= 0,1. No entanto, ele exibiu baixa sensibilidade para o diagnóstico de HC. Testes estruturados (Guy

  3. Incidência de acidente cerebro-vascular embólico na cardiopatia chagásica crônica

    Directory of Open Access Journals (Sweden)

    A. Spina-França

    1974-09-01

    Full Text Available A incidência de acidente vascular cerebral embólico na cardiopatia chagásica crônica foi avaliada a partir de duas séries consecutivas de casos: a primeira compreendendo 63 pacientes com cardiopatia chagásica crônica e, a segunda, 84 pacientes com acidentes cerebrovasculares, 59 dos quais de tipo não hemorrágico. Em relação aos casos de cardiopatia chagásica crônica a incidência de acidente vascular cerebral embólico mostrou-se da ordem de 3,17%; em relação aos acidentes cerebrovasculares, da ordem de 4,76% e quando considerados apenas aqueles de tipo não hemorrágico, da ordem de 6,78%.

  4. Transition of care for the elderly after cerebrovascular accidents - from hospital to the home Transición del cuidado del adulto mayor despues del accidente cerebral vascular del hospital para casa Transição do cuidado com o idoso após acidente vascular cerebral do hospital para casa

    Directory of Open Access Journals (Sweden)

    Rosalina Aparecida Partezani Rodrigues

    2013-02-01

    codificar, clasificar los datos y formular categorías significativas, lo que generó tipologías de cuidado. RESULTADOS Y DISCUSIÓN: La idea central fue la transición del cuidado y mostró el contexto en tres tipologías: El proceso de cuidar del adulto mayor dependiente, Estrategias para el proceso de cuidar e Impacto y aceptación de las limitaciones. CONCLUSIÓN: Los datos nos indicaron que el cuidado para el adulto mayor, después del accidente cerebral vascular es un desafío para la familia. Los datos posibilitaron elaborar una propuesta de modelo para la organización del trabajo, visando la integralidad del cuidado en los servicios de salud, formando una red de cuidado, lo que representa un avance para el área de enfermería.OBJETIVO: examinar a transição do cuidado em famílias que cuidam de idosos que sofreram o primeiro episódio de acidente vascular cerebral. METODOLOGIA: foi utilizado o estudo de caso etnográfico instrumental. A amostra foi constituída por 20 sujeitos, sendo 10 cuidadores e 10 idosos, com 65 anos ou mais, de ambos os sexos, com diagnóstico de primeiro episódio de acidente vascular cerebral, capazes de se comunicarem, demandando cuidado de um cuidador principal na família. Os dados foram coletados por meio de entrevistas, observações, documentos existentes e notas de campo. Foram utilizadas técnicas de análises qualitativa para codificar, classificar os dados e formular categorias significativas, o que gerou tipologias de cuidado. RESULTADOS E DISCUSSÃO: a ideia central foi a transição do cuidado e mostrou o contexto em três tipologias: o processo de cuidar do idoso dependente, estratégias para o processo de cuidar e impacto e aceitação das limitações. CONCLUSÃO: os dados indicaram que o cuidado com o idoso, após o acidente vascular cerebral, é um desafio para a família. Os dados possibilitaram elaborar uma proposta de modelo para a organização do trabalho, visando a integralidade do cuidado nos serviços de sa

  5. Acidente vascular cerebral isquêmico em uma enfermaria de neurologia: complicações e tempo de internação Stroke in a neurology ward: etiologies, complications and length of stay

    Directory of Open Access Journals (Sweden)

    Rodrigo Bomeny de Paulo

    2009-01-01

    Full Text Available OBJETIVOS: Os objetivos deste trabalho foram: avaliar as complicações e o tempo de internação de doentes com acidente vascular cerebral isquêmico (AVCI na fase aguda ou subaguda em uma enfermaria de Neurologia geral em São Paulo; investigar a influência de idade, fatores de risco para doença vascular, território arterial acometido e etiologia sobre as complicações e o tempo de internação. MÉTODOS: Foram coletados prospectivamente dados de 191 doentes com AVCI e posteriormente analisados. RESULTADOS: Cinquenta e um doentes (26,7% apresentaram alguma complicação clínica durante a internação. A pneumonia foi a complicação mais frequente. O tempo médio de internação na enfermaria foi de 16,8±13,8 dias. Na análise multivariável, o único fator que se correlacionou significativamente com menor taxa de complicações foi idade mais jovem (OR=0,92-0,97, p INTRODUCTION: Purposes of this study were: evaluate complications and length of stay of patients admitted with diagnosis of ischemic stroke (IS in the acute or subacute phase, in a general Neurology ward in São paulo, Brazil; investigate the influence of age, risk factors for vascular disease, arterial territory and etiology. METHODS: Data from 191 IS patients were collected prospectively. RESULTS: Fifty-one patients (26.7% presented at least one clinical complication during stay. pneumonia was the most frequent complication. Mean length of stay was 16.8+-13.8 days. Multivariate analysis revealed a correlation between younger age and lower complication rates (OR=0.92-0.97, p < 0.001. presence of complications was the only factor that independently influenced length of stay (OR=4.20; CI=1.928.84; p<0.0001. CONCLUSION: These results should be considered in the planning and organization of IS care in Brazil.

  6. O envelhecimento cortical e a reorganização neural após o acidente vascular encefálico (AVE): implicações para a reabilitação Cortical aging and neural reorganization following cerebral vascular accident (CVA): implications for rehabilitation

    OpenAIRE

    Ilka Nicéia D'Aquino Oliveira Teixeira

    2008-01-01

    Este artigo apresenta uma síntese sobre o envelhecimento do córtex cerebral humano e uma revisão das abordagens para a reabilitação do controle motor após o acidente vascular encefálico (AVE). Na discussão sobre as implicações clínicas na compensação das perdas, é enfatizado que os profissionais de reabilitação devem incentivar os pacientes idosos a usarem os dois membros superiores para a realização das atividades da vida diária (AVDs) ao invés de reforçarem o uso do membro superior não afet...

  7. Use of decompressive craniectomy in the treatment of hemispheric infarction Uso da craniectomia descompressiva no tratamento do acidente vascular cerebral isquêmico hemisférico

    Directory of Open Access Journals (Sweden)

    José Antonio Fiorot Jr.

    2008-06-01

    Full Text Available Decompressive craniectomy (DC has demonstrated efficacy in reducing mortality in hemispheric infarction of the middle cerebral artery. The aim of our study was to compare the outcome of patients submitted to DC to patients treated in a conservative way. Eighteen patients were submitted to DC and 14 received conservative treatment. Neurological status was assessed by the Glasgow Coma Score and National Institutes of Health Stroke Scale score. Mortality, modified Rankin Scale and Barthel Index scores were assessed at 90 days to evaluate outcome. We did not observe reduction in overall mortality and functional outcome in patients submitted to DC. The differences between our group and previously published series are probably related to the neurological status of the patients at the time of therapeutic decision.Craniectomia descompressiva (CD tem demonstrado eficácia em reduzir a mortalidade em pacientes com infarto hemisférico (IH da artéria cerebral média. Este estudo avaliou o prognóstico dos pacientes submetidos a CD comparando a pacientes com IH tratados de maneira conservadora. Dezoito pacientes foram submetidos a CD e 14 receberam tratamento conservador. Escala de Coma de Glasgow e Escala de AVC do National Institutes of Health foram utilizadas para graduar o déficit neurológico. A mortalidade, bem como os escores obtidos na escala modificada de Rankin e índice de Barthel foram avaliados em 90 dias. Não foi observada redução de mortalidade nos pacientes submetidos a CD. Essa diferença entre os nossos resultados e os estudos publicados previamente se deve, provavelmente, à decisão cirúrgica tardia em pacientes com sinais clínicos de herniação cerebral.

  8. Qualidade de vida em sobreviventes de acidente vascular cerebral: instrumentos de avaliação e seus resultados Quality of life in stroke survivors: assessment instruments and their outcomes

    Directory of Open Access Journals (Sweden)

    Juliana Ferreira Mota

    2008-01-01

    Full Text Available OBJETIVOS: Os objetivos deste estudo foram identificar os instrumentos genéricos e específicos utilizados na avaliação da qualidade de vida (QV e os seus resultados em sobreviventes de acidente vascular cerebral (AVC. MÉTODOS: Realizou-se revisão da literatura dos últimos dez anos, com população acima de 18 anos, nos bancos de dados MedLine e Lilacs, cujas publicações utilizassem instrumentos padronizados e validados no país de origem. Combinaram-se os descritores quality of life, cerebrovascular accident, stroke, QV e acidente cerebrovascular. RESULTADOS: Consideraram-se relevantes 96 estudos e 31 entram neste trabalho, de acordo com os critérios de inclusão. Foram encontrados cinco tipos diferentes de instrumentos genéricos/perfil, nove genérico/utility e dois específicos. O mais freqüente foi o SF-36, em 45,2% dos estudos. Observou-se que a baixa QV relacionou-se, principalmente, ao déficit da função física, à presença de depressão ou de seus sintomas, ser do sexo feminino e ser mais idoso. De modo geral, os sujeitos no pós-AVC possuíam pior QV do que aqueles que não sofreram o evento. CONCLUSÃO: Foram encontrados 16 instrumentos para avaliação da QV. A baixa QV foi prevalente nos sobreviventes pós-AVC e se correlacionou com a função física, a depressão, o sexo e a idade.OBJECTIVE: The purpose of this study is to identify generical and specific instruments used for valueing quality of life (QOL and their outcomes in stroke survivors. METHODS: Review of literature of last 10 years, with people above 18 years old, in MedLine and Lilacs database. The instruments used on the studies were validated for the their countries. 96 articles have been considered relevant and 31 were in accordance with inclusion criteria. Five kind of generic/profile, nine generic/utility and two specific instruments were found. The more frequent was SF-36, on the 45,2% of the studies. It has been observed that poverty in quality of

  9. Perfil do cuidador familiar do paciente com seqüela de acidente vascular encefálico Profile of the family caregiver caring for patients with sequels of cerebral vascular accident

    Directory of Open Access Journals (Sweden)

    Natália da Rosa Fonseca

    2008-08-01

    Full Text Available Este estudo descritivo, por meio de uma abordagem qualitativa, teve como objetivo conhecer quem são os cuidadores familiares e entender como se dá a escolha do cuidador dentro da família de pacientes com seqüela de acidente vascular encefálico. Participaram do estudo dez cuidadores familiares através de entrevistas e anotações de campo. As entrevistas foram gravadas e posteriormente transcritas e analisadas. Entre os entrevistados, predominaram as mulheres, casadas, cônjuges e filhos, com média etária de 54 anos. Em relação os fatores que determinam que o familiar assuma os cuidados, percebe-se que o cuidar é muito mais uma obrigação do que uma opção. No entanto, esse sentimento de obrigação une-se ao afeto proveniente das relações estabelecidas anteriormente à doença.This descriptive study using a qualitative approach aimed to identify who are the family caregivers and to understand how the caregiver is chosen amongst the family members of stroke patients. Data were collected by means of a semi-structured questionnaire applied to ten family caregivers. In addition, these caregivers were observed during the interview.The interviews were recorded, transcribed and analyzed. Most of the caregivers who participated in this study were females, married, partners and daughters, with a mean age of 54 years. The statements demonstrated that the "choice" of taking care is not so much an option but closely related to a feeling of obligation. Besides, this choice is also related to the affective relation established with the patient before the illness.

  10. Screening for MELAS mutations in young patients with stroke of undetermined origin Mutações relacionadas à síndrome de MELAS em pacientes jovens com acidente vascular cerebral de etiologia indeterminada

    Directory of Open Access Journals (Sweden)

    Adriana Bastos Conforto

    2007-06-01

    Full Text Available PURPOSE: It has been suggested that mitochondrial disease may be responsible for a substantial proportion of strokes of indetermined origin. We have preliminarily screened for MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes mutations in young patients with cryptogenic strokes. METHOD: The mitochondrial mutations A3243G and T3271C were investigated in 38 subjects aged less than 46 years. Group 1: 15 patients with cryptogenic strokes; Group 2: 3 patients with diagnosis of MELAS syndrome, including stroke-like episodes; Group 3: 20 healthy subjects. RESULTS: The A3243G mutation was absent in all subjects in Groups 1 and 3 but was present in all subjects in Group 2. CONCLUSION: Our results do not support screening for these mutations to diagnose oligosymptomatic forms of MELAS in cryptogenic strokes in the absence of other features of the syndrome. We suggest that clinical findings should guide mitochondrial genetic testing.PROPÓSITO: Foi sugerido que mitocondriopatias possam ser responsáveis por uma proporção substancial de acidentes vasculares cerebrais de etiologia indeterminada. Realizamos um estudo preliminar de pesquisa de mutações relacionadas à síndrome de MELAS (encefalomiopatia mitocondrial, acidose lática e episódios "stroke-like" em pacientes jovens com acidentes vasculares cerebrais criptogênicos. MÉTODO: As mutações mitocondriais A3243G e T3271C em 38 indivíduos com menos de 46 anos. Grupo 1: 15 pacientes com acidentes vasculares cerebrais criptogênicos; Grupo 2: 3 pacientes com diagnóstico de síndrome de MELAS, incluindo episódios "stroke-like"; Grupo 3: 20 voluntários saudáveis. RESULTADOS: A mutação A3243G esteve ausente em todos os indivíduos dos Grupos 1 e 3 mas esteve presente em todos os indivíduos do Grupo 2. CONCLUSÃO: Nossos resultados sugerem que não há utilidade em pesquisar estas mutações para diagnosticar formas oligossintomáticas de MELAS em acidentes

  11. Estudo das freqüências dos principais fatores de risco para acidente vascular cerebral isquêmico em idosos Study of the main risk factors frequencies for ischemic cerebrovascular disease in elderly patients

    Directory of Open Access Journals (Sweden)

    Sueli Luciano Pires

    2004-09-01

    Full Text Available Foram estudados retrospectivamente 262 pacientes com diagnóstico clínico de acidente vascular cerebral isquêmico (AVCi permanente, com idade igual ou superior a 60 anos, selecionados dos 1015 registros da Liga de Aterosclerose da Clínica Neurológica da ISCMSP, de 1990 a 2002. O estudo focalizou as freqüências dos fatores de risco modificáveis para AVCi nesta população idosa, considerando-se sexo e faixa etária dos pacientes. Os resultados evidenciaram que a hipertenção arterial sistêmica é significativamente freqüente (87,8% entre pacientes idosos com AVCi, independentemente do sexo e da faixa etária. Tabagismo (46,9% e etilismo (35,1% revelaram-se fatores de riscos modificáveis freqüentes especialmente entre os homens. As cardiopatias (27,0%, o Diabete Melito (19,9% e as dislipidemias (15,6% também se revelaram fatores de risco modificáveis freqüentes em pacientes idosos com AVCi, em ambos os sexos e em ambas as faixas etárias estudadas (60 a 70 anos e mais que 71 anos. Foi relativamente baixa a freqüência de hiperuricemia nesta amostra.Two hundred and sixty two patients with clinical diagnosis of permanent ischemic stroke, all of them aged 60 or more were retrospectively studied from the 1015 cerebrovascular diseases (CVD records of the Atherosclerosis Ligue of the Neurology Clinics of the ISCMSP, from 1990 to 2002. The study emphasized modifiable risk factors frequencies for ischemic stroke in this population, considering gender and age of the patients. Results have evidenced that systemic arterial hypertension is a main risk factor significantly frequent in old people (87.8%, independently of gender and age. Smoking (46.9% and alcohol consumption (35.1% have revealed to be very frequent important modifiable risk factors especially among men. Lower frequencies have been presented for cardiac diseases (27.0%, Diabetes Melitus (19.9%, and dislipidemia (15.6% as risk factors for ischemic stroke in old people of both

  12. Importance of retardation and fatigue/interest domains for the diagnosis of major depressive episode after stroke: a four months prospective study Lentificação e fadiga/interesse no diagnóstico do episódio depressivo maior após o acidente vascular cerebral: um estudo prospectivo de quatro meses

    Directory of Open Access Journals (Sweden)

    Luisa de Marillac Niro Terroni

    2009-09-01

    Full Text Available OBJECTIVE: Post-stroke major depressive episode is very frequent, but underdiagnosed. Researchers have investigated major depressive episode symptomatology, which may increase its detection. This study was developed to identify the depressive symptoms that better differentiate post-stroke patients with major depressive episode from those without major depressive episode. METHOD: We screened 260 consecutive ischemic stroke patients admitted to the neurology clinic of a university hospital. Seventy-three patients were eligible and prospectively evaluated. We assessed the diagnosis of major depressive episode using the Structured Clinical Interview for DSM-IV and the profile of depressive symptoms using the 31-item version of the Hamilton Depression Rating Scale. For data analysis we used cluster analyses and logistic regression equations. RESULTS: Twenty-one (28.8% patients had a major depressive episode. The odds ratio of being diagnosed with major depressive episode was 3.86; (95% CI, 1.23-12.04 for an increase of one unit in the cluster composed by the domains of fatigue/interest and retardation, and 2.39 (95% CI, 1.21-4.71 for an increase of one unit in the cluster composed by the domains of cognitive, accessory and anxiety symptoms. The domains of eating/weight and insomnia did not contribute for the major depressive episode diagnosis. CONCLUSION: The domains of retardation and interest/fatigue are the most relevant for the diagnosis of major depressive episode after stroke.OBJETIVO: O episódio depressivo maior após acidente vascular cerebral é muito frequente, mas é subdiagnosticado. Pesquisas têm investigado a sintomatologia do episódio depressivo maior pós-acidente vascular cerebral, o que pode facilitar sua identificação. Este estudo foi desenvolvido para identificar os sintomas depressivos que melhor diferenciam pacientes com episódio depressivo maior daqueles sem episódio depressivo maior após o acidente vascular cerebral

  13. Patent foramen ovale in a cohort of young patients with cryptogenic ischemic stroke Forame oval patente em uma coorte de pacientes jovens com acidente vascular cerebral isquêmico

    Directory of Open Access Journals (Sweden)

    Marcus Tulius T. Silva

    2005-06-01

    Full Text Available OBJECTIVE: Although its role is a matter of debate, some studies described a higher prevalence of patent foramen ovale (PFO and atrial septal aneurysm (ASA in young stroke patients, with higher risk with PFO / ASA association (OR 4.96. The aim of this study was determine the prevalence of PFO and ASA in a cohort of cryptogenic ischemic stroke (IS patients younger than 55 years and to follow-up after surgical or percutaneous endovascular closure (PEC. METHOD: In 21 months we identified all patients less than 55 years old with IS who were admitted to our hospital. Cryptogenic IS was considered if there is not an identifiably cause to cerebral ischemia. Transesophageal echocardiography (TEE was performed in all patients. After interatrial septal abnormalities diagnosis, percutaneous device closure was offered to all. Patients were followed monthly and keeped with oral AAS or Clopidogrel. RESULTS: We identified 189 patients with IS and 32 were less than 55 years old (16.9%. In 29 the IS was cryptogenic. TEE was performed in all patients and some form of interatrial septal abnormality was identified in 12 (12/29 - 41.3%; 5 had a PFO and in 7 there was PFO plus ASA. Ten patients were submitted to PEC and 2 were submitted to surgical closure. In mid-term follow-up (28 months no ischemic events occurred and 2 patients related disappearance of migraine symptoms. CONCLUSION: Our small series description is in accordance with other studies and suggests a possible relation between interatrial septal abnormalities and IS in a cohort of young patient.OBJETIVO: A associação das anormalidades do septo interatrial - forame oval patente (FOP e aneurisma de septo interatrial (ASA - com acidente vascular cerebral isquêmico (AVCI ainda é questão de incerteza para muitos autores. No entanto, vários estudo mostram que em pacientes jovens tais anormalidades podem estar relacionadas à gênese de eventos isquêmicos. Nosso objetivo é descrever a prevalência do

  14. Does botulinum toxin improve the function of the patient with spasticity after stroke? Toxina botulínica proporciona melhora funcional em pacientes com espasticidade secundária a acidente vascular cerebral?

    Directory of Open Access Journals (Sweden)

    Eduardo Cardoso

    2007-09-01

    Full Text Available Post-stroke spasticity is an important cause of disability in adults, due to muscle hyperactivity, which results in limb stiffness and muscle spasm. The prognosis for these patients depends on several features such as early management and adequate physical therapy to avoid muscle shortening, pain, and their consequences. Although several papers have shown that intramuscular injections of botulinum toxin type A (BT-A decreases spasticity in post-stroke patients, few authors have demonstrated functional improvement after this therapy. In order to assess if individualized BT-A injections improves upper limb function in post-stroke spastic patients, we prospectively followed 20 consecutive patients of 18 years of age or more with spastic hemiparesis secondary to stroke. Fulg-Meyer scale modified for upper limbs, measure of functional independence (MFI, Ashworth modified scale, and goniometry were applied in the beginning of the investigation and in the 16th and 32nd weeks. BT-A was applied at baseline and in the 16th week. All subjects were submitted to rehabilitation therapy. All patients showed improvement according to Ashworth modified scale and increase in the range of motion, which were sustained until the 32nd week (pEspasticidade secundária a acidente vascular cerebral (AVC é importante causa de incapacidade em adultos. O prognóstico para estes pacientes depende de vários fatores como tratamento precoce e terapia física adequada, evitando encurtamento muscular, dor e outras conseqüências. Vários estudos têm demonstrado que aplicacões intramusculares de toxina botulínica do tipo A (TxB-A reduzem a espasticidade após AVC, entretanto poucos autores observaram melhora funcional de membros superiores com esta terapêutica. Para determinar se aplicações individualizadas de TxB-A melhoram a função no membro superior espástico de pacientes com hemiparesia secundária a AVC, acompanhamos 20 pacientes com história de AVC entre 6 meses

  15. Are the angiotensin-converting enzime gene and acticity risk factors for stroke? São fatores de risco para acidente vascular cerebral o gene e a atividade da enzima conversora de angiotensina ?

    Directory of Open Access Journals (Sweden)

    Miris Dikmen

    2006-06-01

    Full Text Available Stroke is a multifactorial disease in which genetic factors play an important role. This study was carried out to determine angiotensin-converting enzyme (ACE gene polymorphism in Turkish acute stroke patients and to establish whether there is an association of angiotensin-converting enzyme gene I/D polymorphism with clinical parameters. In this study 185 patients and 50 controls were recruited. We have investigated the association among the allelic distribution of the insertion/deletion (I/D polymorphism of the ACE gene identified by polymerase chain reaction. Distribution of ACE gene I/D genotypes and allele frequencies in patients were not significantly different from controls. D allele frequencies were 57.8% in patients versus 53.0% in controls and I allele 42.2% versus 47% respectively. History of hypertension, stroke, renal, heart and vessel diseases incidence and age, gender, systolic-diastolic blood pressures and creatinine levels were significantly high in patients. But these results and ACE activities had no significant differences among the ACE genotypes in patients and controls. Our results suggest that the ACE gene polymorphism is not associated with the pathogenesis of stroke in Turkish stroke patients.O acidente vascular cerebral (AVC é doença multifatorial em que fatores genéticos desempenham papel importante. Este estudo foi desenvolvido para verificar o polimorfismo do gene da enzima conversora da angiotensina (ECA em pacientes turcos com AVC agudo e estabelecer se existe associação do gene I/D da ECA com parâmetros clínicos. O estudo foi realizado com 185 pacientes e 50 controles. A associação entre a distribuição alélica da inserção / deleção (I/D do polimorfismo do gene da ECA foi estudada pela reação em cadeia da polimerase. A distribuição dos genótipos I/D do gene da ECA e suas freqüências não apresentaram significância estatística quando comparados os pacientes e controles. As freqüências dos

  16. Cerebrovascular accident in the aged: changes in family relations El anciano tras accidente cerebrovascular: alteraciones en el relacionamento familiar O idoso após acidente vascular cerebral: alterações no relacionamento familiar

    Directory of Open Access Journals (Sweden)

    Sueli Marques

    2006-06-01

    desarrollar un plan de acción que pueda favorecer las relaciones y la adaptación de la familia a las demandas, con vistas a mejorar las condiciones de vida de sus miembros, incluso el anciano.Os objetivos deste estudo foram: identificar os idosos atendidos, na Unidade de Emergência de um hospital governamental do município de Ribeirão Preto-SP, com diagnóstico médico de acidente vascular cerebral, e suas respectivas famílias, bem como identificar as alterações, no relacionamento familiar, que ocorreram após o evento. Utilizou-se a Técnica de Incidentes Críticos adaptada para identificar as alterações no relacionamento familiar ocorridas após a doença e, para a análise, a reflexão do Caminho do Pensamento. A amostra constou de 11 famílias, totalizando 34 participantes. A análise das conseqüências revelou as alterações no relacionamento familiar, que constituíram 13 subcategorias, 5 positivas e 8 negativas, perfazendo o total de 58 alterações, sendo 30 positivas e 28 negativas. O estudo revelou a necessidade de trabalhar com a família para identificar as alterações e desenvolver um plano de ações que possa favorecer as relações e a adaptação da família às demandas, com vistas a melhorar as condições de vida de seus membros, inclusive o idoso.

  17. Acidentes vasculares cerebrais embólicos na cardiopatia chagásica crônica

    Directory of Open Access Journals (Sweden)

    Israel Nussenzveig

    1953-12-01

    Full Text Available Os autores apresentam oito casos de cardiopatia crônica chagásica, comprovada pela reação de Machado-Guerrero, em cuja evolução ocorreram acidentes vasculares cerebrais. Discutem a etiología dêsses acidentes, afastando os fatôres etiológicos conhecidos e formulando a hipótese de embolia cerebral a partir de trombose mural cardíaca. Quatro casos foram fatais, tendo sido necropsiados. Em dois dêles os achados anátomo-patológicos vieram comprovar a hipótese, enquanto, dos dois restantes, em um havia concomitantemente artériosclérose cerebral difusa e no outro verificou-se amolecimento cerebral, na ausência de qualquer dos fatôres etiológicos conhecidos, mas não havia trombose nas cavidades esquerdas do coração; é lembrada a possibilidade de trombo mural fracamente aderido ao endocárdio, que se tivesse desprendido in totum. Embora não tivessem conseguido a comprovação de sua hipótese, os autores são de opinião que êste foi o mecanismo patogênico nos 8 casos apresentados e chamam a atenção para a doença de Chagas como fator etiológico da embolia cerebral.

  18. Disfunção intestinal em pacientes com lesão cerebral decorrente de acidente vascular cerebral e traumatismo craniencefálico: estudo retrospectivo de uma série de casos

    Directory of Open Access Journals (Sweden)

    Cinthia Carlos Dourado

    2012-01-01

    Full Text Available La disfunción del intestino es una queja común entre los pacientes con daño cerebral debido a una lesión cerebral traumática y accidente cerebrovascular. Este estudio tuvo como objetivo investigar la prevalencia de disfunción del intestino (incontinencia y constipación en pacientes con daño cerebral debido a una lesión cerebral traumática y accidente cerebrovascular admitidos para la rehabilitación. Este es un estudio retrospectivo de una serie de casos a partir del análisis de los datos de 138 expedientes de los pacientes ingresados en el primer semestre de 2009. La prevalencia de disfunción del intestino fue de 41%, siendo 33 (24% incontinencia anal y 37 (27%, constipación. El comprometimiento motor, ayuda a la movilidad, cambios en la memoria y la comunicación se asocian con la presencia de la incontinencia anal. La prevalencia de disfunción del intestino es alta en esta población, identificar en forma temprana los factores relacionados, y promover el reentrenamiento intestinal pueden ayudar a mejorar la calidad de sus vidas.

  19. Burden and modifications in life from the perspective of caregivers for patients after stroke Sobrecarga y modificaciones de vida en la perspectiva de los cuidadores de pacientes con accidente vascular cerebral Sobrecarga e modificações de vida na perspectiva dos cuidadores de pacientes com acidente vascular cerebral

    Directory of Open Access Journals (Sweden)

    Huana Carolina Cândido Morais

    2012-10-01

    ñados por el Programa de Servicio Domiciliar de tres hospitales. La colecta de los datos ocurrió mediante entrevista para identificar modificaciones de vida, y con la aplicación de tres escalas para investigar la sobrecarga percibida, estado mental y sufrimiento psíquico. Son ellas, respectivamente: Caregiver Burden Scale (CBS, Mini Examen del Estado Mental (MEEM y Self Reported Questionnaire (SRQ. Los cuidadores, en su mayoría, eran del sexo femenino, casados (as e hijo (as de los pacientes después del AVC. Edad Media de 48,2 años (±12,4. Las modificaciones de vida más citadas fueron referentes a la rutina diaria, a las actividades de ocio y agotamiento o cansancio. En cuanto a la sobrecarga, se destacaron las dimensiones Tensión general, Aislamiento y Decepción. Se verificó mayor sobrecarga cuanto más síntomas de sufrimiento psíquico el cuidador presentase, en la ausencia de cuidador secundario y cuando los cuidadores principales relataron percibir modificación en el cuerpo y en la salud. CONCLUSIÓN: no fue observada asociación de la sobrecarga con el estado mental del cuidador. Entender la coyuntura del cuidado, mediante análisis del recargo de trabajo, y del conocimiento de la situación biopsicosocial, suministrará subsidios para la actuación del enfermero para reducir la carga generada para los cuidadores familiares.OBJETIVO: analisar o impacto do cuidar para o cuidador familiar de paciente após acidente vascular cerebral (AVC, correlacionando modificações de vida e sofrimento psíquico com a sobrecarga percebida. MÉTODO: estudo transversal, quantitativo, realizado de janeiro a abril de 2010, em Fortaleza, Ceará, Brasil. RESULTADO: investigaram-se 61 indivíduos, acompanhados pelo Programa de Atendimento Domiciliar (PAD, de três hospitais. A coleta dos dados ocorreu mediante entrevista para identificar modificações de vida, e com a aplicação de três escalas para investigar sobrecarga percebida, estado mental e sofrimento psíquico. S

  20. Análise de custo-efetividade da trombólise com alteplase no Acidente Vascular Cerebral Análisis de costo-efectividad de la trombólisis con alteplase en el accidente vascular cerebral Analysis of the cost-effectiveness of thrombolysis with alteplase in stroke

    Directory of Open Access Journals (Sweden)

    Denizar Vianna Araújo

    2010-07-01

    Full Text Available FUNDAMENTO: Acidente Vascular Cerebral (AVC é a principal causa de óbito no Brasil e pouca informação está disponível sobre custo do tratamento. OBJETIVO: Elaborar análise de custo-efetividade da trombólise no AVC, até três horas após o início dos sintomas, comparando o tratamento com alteplase versus conservador, sob a perspectiva do Sistema Único de Saúde (SUS. MÉTODOS: Modelo de análise de decisão foi desenvolvido para comparar os dois tratamentos. Ciclos foram considerados, durante os quais pacientes poderiam transitar entre cinco estágios de incapacidade pós-AVC, baseados na escala modificada de Rankin. A probabilidade de apresentar hemorragia intracerebral no primeiro ano foi obtida do ensaio NINDS. Para os anos subsequentes, ciclos de um ano foram considerados, para contabilizar a mortalidade dos pacientes. O desfecho foi expresso em Anos de Vida Ajustados pela Qualidade (QALY. Tanto os custos diretos quanto os indiretos foram considerados na análise. Custos e desfecho foram descontados em 5% ao ano. RESULTADOS: No primeiro ano, o QALY ganho foi de 0,06 para ambos os gêneros, com custo incremental de R$ 2.558 para homens e R$ 2.312 para mulheres. A razão de custo-efetividade incremental em um ano foi de R$ 40.539 / QALY (USD 28.956 para homens e R$ 36.640 / QALY (USD 26.171 para mulheres. Após o segundo ano, o tratamento com alteplase reduziu o custo do tratamento (índice de Paridade do Poder de Compra US$ 1 = R$ 1,4. CONCLUSÃO: Terapia trombolítica com alteplase nas primeiras três horas após o AVC é custo-efetiva no cenário do Sistema Único de Saúde.FUNDAMENTO: Accidente Vascular Cerebral (AVC es la principal causa de óbito en el Brasil y poca información está disponible sobre el costo del tratamiento. OBJETIVO: Elaborar análisis de costo-efectividad de la trombólisis en el AVC, hasta tres horas después del comienzo de los síntomas, comparando el tratamiento con alteplase versus conservador, bajo la

  1. Cerebrovascular disorders in childhood: etiology, clinical presentation, and neuroimaging findings in a case series study Acidente vascular cerebral na infância: etiologia, apresentação clínica e achados de neuroimagem em um estudo de série de casos

    Directory of Open Access Journals (Sweden)

    André P.C. Matta

    2006-06-01

    Full Text Available OBJECTIVE: To describe the main etiologies, neurological manifestations and neuro-imaging findings among children with sequelae of cerebrovascular disorders. METHOD: Case series study of children whose diagnosis was stroke sequelae. Variables studied were age at the time of first episode, number of episodes, etiology, motor deficits, epilepsy, and effected vascular territory. RESULTS: Twenty three patients were studied. Average age at first episode was 6.91 (±2.08 years. Fourteen patients were female. The number of stroke events per patient ranged from one to five. The most frequent etiologies were heart disease and sickle cell anemia. The most frequent neurological deficit was right hemiparesis. Nine patients experienced seizures. The left middle cerebral artery was the most affected vascular area. CONCLUSION: Our findings are similar to those described in the literature. Despite a careful investigation, some causes of stroke remain unidentified.OBJETIVO: Descrever as principais etiologias, manifestações neurológicas e achados de neuroimagem entre crianças com seqüela de acidente vascular cerebral (AVC. MÉTODO: Estudo de série de casos de crianças com seqüela de AVC isquêmico ou hemorrágico, analisando-se as variáveis: idade no primeiro episódio, número de eventos, etiologia, déficit motor, epilepsia e território vascular acometido. RESULTADO: Vinte e três pacientes foram incluídos, sendo 14 do sexo feminino. A idade do primeiro episódio foi 6.91 (±2,08 anos. O número de eventos por paciente variou entre 1 e 5. As etiologias mais freqüentes foram cardiopatia e anemia falciforme. O déficit mais encontrado foi a hemiparesia direita. Nove pacientes apresentaram convulsões. A artéria cerebral média esquerda foi o território vascular mais afetado. COCLUSÃO: Os achados deste trabalho estão de acordo com a literatura em geral. Apesar de extensa investigação, alguns casos permanecem sem definição etiológica.

  2. Botulinum toxin A and physiotherapy intervention in the treatment of the painful shoulder after stroke: case report Toxina botulínica A e intervenção fisioterapêutica no tratamento do ombro doloroso pós acidente vascular cerebral: relato de caso

    Directory of Open Access Journals (Sweden)

    Suellen M. Marinho dos Santos Andrade

    2007-10-01

    Full Text Available The syndrome of the painful shoulder is considered a common finding in patients who suffered stroke. Several therapeutic modalities are suggested for the improvement of the patients’ clinical condition. In this report, a case of syndrome of the painful shoulder will be discussed, whose treatment consisted of the use of botulinum toxin A associated to physiotherapy. After a four-month treatment, significant improvements occurred concerning pain, spasticity, range of motion and quality of life, suggesting that this therapeutic association is an efficient tool against the incapacitating effects related to this syndrome. A síndrome do ombro doloroso é considerada um achado comum em pacientes que sofreram acidente vascular cerebral. Várias modalidades terapêuticas são apontadas para melhoria do quadro clínico dos pacientes. Neste relato, será apresentado um caso de síndrome do ombro doloroso, cujo tratamento consistiu no emprego de toxina botulínica A associada à fisioterapia. Após quatro meses de tratamento, houve melhorias significativas quanto à dor, espasticidade, amplitude de movimento e qualidade de vida, e isso sugere ser essa associação terapêutica uma ferramenta eficaz contra os efeitos incapacitantes relacionados a esta síndrome.

  3. Cuidar de pessoa incapacitada por acidente vascular cerebral no domicílio: o fazer do cuidador familiar El cuidado de la persona incapacitada por accidente cerebro vascular en el domicilio: el hacer del cuidador familiar Taking care of persons handicapped by cerebral vascular accident at home: the familial caregiver activity

    Directory of Open Access Journals (Sweden)

    Nara Marilene Oliveira Girardon Perlini

    2005-06-01

    incapacitated by cerebral vascular accident. The sample was comprised of 35 family caregivers, most of them women, wives or daughters. The care given is directly related to the degree of incapacity of the person who is being cared for. The orientation received indicated no commitment of professionals for the continuity of the care. The caregivers learn in daily practice how to care, based on observation and assistance to nursing during the internment period. The difficulties are related to physical effort, to lack of information and fear, to the embarassment and the shame of handling someone else's body. The study focuses on the need for preparation for hospital discharge, emphasizes the family as a concrete space for care; and observed an increase in life expectancy.

  4. Educação em saúde e família: o cuidado ao paciente, vítima de acidente vascular cerebral - DOI: 10.4025/actascihealthsci.v26i1.1663 Health education in family:nursing CVA patients - DOI: 10.4025/actascihealthsci.v26i1.1663

    Directory of Open Access Journals (Sweden)

    Ana Ruth Macêdo Monteiro

    2004-04-01

    Full Text Available O presente estudo objetiva identificar o conhecimento dos familiares de pacientes acometidos por AVC (Acidente Vascular Cerebral sobre a doença e sobre seus cuidados e, ainda, elaborar uma cartilha de orientação quanto aos cuidados domiciliares a esses pacientes. Participaram da presente pesquisa 50 familiares de pacientes acometidos por AVC, os quais estavam acompanhando os pacientes por um período mínimo de 3 dias. Os dados obtidos da análise dos depoimentos dos familiares estão agrupados em 3 categorias: conhecendo as famílias, identificando o conhecimento dos familiares, atendendo às solicitações dos familiares. A cartilha de orientação, elaborada de acordo com o levantamento das principais dúvidas e/ou dificuldades dos familiares, busca favorecer o processo educativo dessas famílias no ambiente hospitalar, promovendo, assim, seu envolvimento nesse processo. A importância de um trabalho nesse sentido está baseada na possibilidade de uma maior compreensão dos problemas vivenciados pelos pacientes acometidos por AVC e por suas famílias, auxiliando, dessa forma, o enfermeiro a desenvolver ações visando minimizá-los e tornar a situação menos traumática para ambos.The present study aims to identify the knowledge of CVA (Cerebral Vascular Accident patients' close relatives on the disease and its specific cares; and also, to elaborate a guide for the home care of those patients. The present research evaluated family members from 50 CVA patients. These relatives were taking care of the patients for at least 3 days. The data obtained from the testimonies analysis are grouped in three categories: acquainting the families; identifying the family’s knowledge; assisting family’s requests. The guide, organized according to the relatives' main doubts and difficulties, intends to help the educational process of those families in the hospital’s atmosphere, promoting their engagement in the process. This work makes possible a

  5. Papel da curva de agregação plaquetária no controle da antiagregação na prevenção secundária do acidente vascular cerebral isquêmico Platelet aggregation test: application in the control of antiplatelet aggregation in the secondary prevention of stroke

    Directory of Open Access Journals (Sweden)

    Patrícia Regina Piedade

    2003-09-01

    Full Text Available INTRODUÇÃO: O acidente vascular cerebral (AVC é atualmente a primeira causa de morte no Brasil. O risco de recorrência de AVC é de aproximadamente 30% em cinco anos. Agentes antiagregantes plaquetários são frequentemente prescritos para a prevenção de recorrência do AVC, porém sem um parâmetro laboratorial de ajuste terapêutico. OBJETIVO: Determinar a aplicabilidade da curva de agregação plaquetária, no controle do antiagregante, na prevenção secundária do acidente vascular cerebral isquêmico (AVCi. MÉTODO: Estudo retrospectivo de janeiro de 1990 a janeiro de 2001; foram analisados 189 pacientes com diagnóstico de AVCi acompanhados durante este período com curva de agregação plaquetária. Foram excluídos os portadores de doenças cardioembólicas. Consideraram-se hipoagregados os doentes com agregação plaquetária ativada pelo ADP e/ou pela adrenalina menor ou igual a 50%. Os doentes tiveram acompanhamento por 1 a 6 anos e a taxa de recorrência de AVCi foi comparada entre os normoagregados e os hipoagregados. RESULTADOS: Nove doentes apresentaram novo AVCi no período do seguimento. Entre os hipoagregados ocorreu 2,6% de recidiva e entre os normoagregados, 15,1% (0,03INTRODUCTION: Stroke is the leading cause of death in Brazil. The risk of suffering a recurrent stroke is around 30% in 5 years. Antiplatelet therapy has been frequently used to prevent recurrent strokes without laboratory control. OBJECTIVE: To determine the value of the platelet aggregation test in the control of antiplatelet aggregation in the secondary stroke prevention. METHOD: Retrospective study from January 1990 to January 2001 with 189 patients with stroke that were followed up during this period with platelet aggregation curve. Patients with cardioembolic disease were excluded. Low aggregation rates of platelet aggregation activated by ADP and/or epinephrine lower or equal to 50% were considered. Patients were followed up for a period from one

  6. Perfil de indivíduos com sequela de acidente vascular encefálico

    OpenAIRE

    Costa, Tatiana Ferreira da; Macêdo Costa, Katia Nêyla de Freitas; Martins, Kaisy Pereira; Fernandes, Maria das Graças Melo; Gomes, Thayris Mariano; Galdino, Milena Melo

    2015-01-01

    Introdução: O acidente vascular encefálico (AVE) caracteriza-se ainda como um grande problema de saúde pública e a principal causa de incapacidade neurológica grave. Objetivo: Analisar o perfil dos indivíduos com sequela de AVE. Metodologia: Pesquisa descritiva, transversal, com abordagem quantitativa, realizada no domicilio dos pacientes com sequela de AVE (João Pessoa/PB). Resultados: Evidenciou uma predominância do sexo feminino; idosos; casados; baixo grau de escolaridade; e baixa renda. ...

  7. Cuidado de enfermagem no adoecimento por acidente vascular encefálico: revisão integrativa da literatura brasileira

    OpenAIRE

    Samia Jardelle Costa de Freitas Maniva; Consuelo Helena Aires de Freitas

    2012-01-01

    Revisão integrativa que objetivou analisar o conhecimento acerca do cuidado de enfermagem no adoecimento por Acidente Vascular Encefálico na base de dados LILACS. Os critérios de elegibilidade dos artigos foram os seguintes: correspondência aos termos “cuidado” e “acidente vascular encefálico”; publicação em língua portuguesa; disponibilidade de texto completo; ano de publicação no período de 2000 a 2011. Encontraram-se vinte publicações cujos dados foram coletados por meio de formulário. A a...

  8. Desempenho Manual do Membro Superior Ipsilesional em Indivíduos com Acidente Vascular Encefálico

    OpenAIRE

    Alves, Katia

    2014-01-01

    Introdução: nos pacientes que sofreram um Acidente Vascular Encefálico são incididos programas de reabilitação que visam principalmente o hemicorpo contralesional, negligenciando o lado ipsilesional. Porém, estão descritas alterações sensitivas e motoras do membro superior ipsilesional neste grupo populacional. Objetivo: avaliar os défices de sensibilidade, destreza grossa e fina e força de preensão da mão ipsilesional em indivíduos com diagnóstico de Acidente Vascular Encefálico, comparando ...

  9. Efeito da administração de uma dieta enteral com antioxidantes sobre as concentrações plasmáticas de tióis totais, carbonilas de proteínas e malondialdeído após acidente vascular cerebral

    Directory of Open Access Journals (Sweden)

    Lorene Simioni Yassin

    2012-04-01

    Full Text Available OBJETIVO: Avaliar o efeito da administração de uma dieta enteral industrializada com antioxidantes sobre as concentrações plasmáticas de tióis totais, carbonilas de proteínas e malondialdeído em pacientes após acidente vascular cerebral. MÉTODOS: A amostra foi constituída de 14 pacientes de um hospital geral que iniciaram nutrição enteral 48 horas após o evento. Falência múltipla, insuficiência hepática, obesidade mórbida e diabetes Mellitus associados foram critérios de exclusão. A dieta industrializada ofertada por gotejamento contínuo, com uso de bombas infusoras, continha mix de carotenoides, vitaminas C, E e minerais Se, Zn e Cu em sua formulação. As amostras de sangue foram coletadas antes do início da administração da dieta e após cinco dias de início da dieta enteral, somente de pacientes que tivessem recebido o volume necessário para completar o gasto energético total. Tióis plasmáticos e carbonilas de proteína foram determinados por meio do Reagente de Ellman e pela reação com dinitrofenilhidrazina respectivamente. O malondialdeído foi obtido pela determinação de substâncias reativas do ácido tiobarbitúrico. RESULTADOS: A média de idade foi M=70,3, DP=14,1 anos. Todos receberam acima de 100% da Dietary Reference Intakes para nutrientes antioxidantes, que não ultrapassaram os limites superiores toleráveis de ingestão. Não houve alteração da concentração de tióis, mas houve aumento da formação de carbonilas de proteínas (p=0,034. Nos pacientes entubados, esse marcador mostrou-se significativamente maior (p=0,048 após administração da dieta. Não houve diferença nas concentrações de malondialdeído após a oferta de antioxidantes dietéticos. CONCLUSÃO: A análise de biomarcadores não demonstrou redução do estresse oxidativo após administração de dieta enteral industrializada com antioxidantes.

  10. Acidente vascular cerebral de etiologia rara com indicação cirúrgica urgente: caso clínico Stroke of a rare etiology with need of urgent surgery: case report

    Directory of Open Access Journals (Sweden)

    Ana Vieira Baptista

    2012-03-01

    Full Text Available Doente de 19 anos com quadro de febre com 8 dias de evolução e posterior instalação súbita de afasia, hemiparésia esquerda e alterações do comportamento. Aumento das proteínas de fase aguda no estudo analítico. TAC e RMN crânio-encefálicas revelaram lesão isquémica temporo-parietal direita. Ecocardiograma excluiu endocardite. Eco-döppler e angio-TAC carotídeo-vertebrais mostraram formação vegetante, móvel com a pulsação cardíaca, na artéria carótida comum direita. Submetido, de urgência, a cirurgia carotídea. Intraoperatoriamente constatou-se a presença de trombo ligeiramente aderente à artéria carótida comum e na dependência de lesão da íntima subjacente, tendo-se procedido à sua exérese e a arteriorrafia primária. Aponta-se como etiologia mais provável do quadro, uma vasculite secundária a infecção por HSV1 (infecção activa ou por Rickettsia conorii.19 years old patient with fever for 8 days associated with sudden aphasia, left hemiparesis and abnormal behavior. Increased acute phase proteins in the analytical study. Head CT scan and MRI revealed a right temporo-parietal ischemic lesion. An echocardiogram excluded endocarditis. Ultrasound and CT angiography scanning of the extracranial cerebral circulation showed a vegetative formation, mobile with the heartbeat, in the right common carotid artery. Submitted, urgently, to carotid surgery. Intraoperatively, a slightly adherent thrombus to the common carotid artery was found and in the dependence of an underlying injury to the intima. The thrombus was ressected and a primary arteriorrhaphy performed. It is pointed out a vasculitis secondary to HSV1 (active infection or to Rickettsia conorii infection as the most likely etiology of the clinic.

  11. Avaliação dos níveis de hiper-homocisteinemia, vitamina E, selênio, cobre, ceruloplasmina e ferritina em pacientes com diagnóstico de acidente vascular cerebral isquêmico Assesment of homocysteine, vitamin E, selenium, copper, ceruloplasmin and ferritin levels in patients with ischemic stroke diagnosis

    Directory of Open Access Journals (Sweden)

    Lillian Harboe-Gonçalves

    2007-02-01

    Full Text Available OBJETIVO: Avaliar níveis sangüíneos de hiper-homocisteinemia, vitamina E, selênio, cobre, ceruloplasmina e ferritina em pacientes com diagnóstico de acidente vascular cerebral isquêmico (AVCI. CASUÍSTICA, MATERIAIS E MÉTODOS: Estudo transversal analítico de 104 pacientes diagnosticados com AVCI e 98 controles. Dosagem de homocisteína e vitamina E feita por cromatografia líquida de alta performance. O selênio foi dosado por tecnologia de espectrometria de massa por plasma indutivamente acoplado; o cobre o foi por colorimetria; a ceruloplasmina, por nefelometria; e a ferritina, por imunoensaio enzimático conjugado à fluorescência (Elfa. Análise estatística feita com testes t de Student e análise de variância. RESULTADOS: Encontrada hiper-homocisteinemia em 43% dos pacientes e 13% dos controles. Os valores obtidos nas dosagens de vitamina E, cobre, ceruloplasmina e ferritina foram significativamente maiores no grupo paciente do que no grupo controle. Quanto ao selênio, a diferença entre os dois grupos não foi significativa. DISCUSSÃO: Níveis de hiper-homocisteinemia foram maiores que os encontrados na literatura, podendo ser conseqüência da genética ou dos hábitos alimentares da população. Os resultados encontrados para vitamina E, selênio, cobre, ceruloplasmina e ferritina coincidem com os de alguns trabalhos publicados, mas o modelo deste estudo não avalia se os níveis de vitamina E e selênio foram alterados pelo AVCI ou por mudanças nos hábitos dos pacientes. A ferritina e a ceruloplasmina podem ser marcadores de AVCI, e não fator causal da sua patogênese. CONCLUSÃO: A hiper-homocisteinemia é mais prevalente nos pacientes diagnosticados com AVCI. Os níveis de vitamina E, cobre, ceruloplasmina e ferritina mais elevados encontrados nos pacientes não podem ser atribuídos à ocorrência de AVCI.OBJECTIVE: To assess blood levels of hyperhomocysteinaemia, vitamin E, selenium, copper, ceruloplasmin and

  12. Vivenciando a sobrecarga ao vir-a-ser um cuidador familiar de pessoa com acidente vascular cerebral (AVC: análise do conhecimento Viviendo la sobrecarga al convertirse en cuidador familiar de personas con accidente cerebrovascular: análisis del conocimiento Living the burden in becoming a family caregiver for a cerebrovascular accident survivor: knowledge analysis

    Directory of Open Access Journals (Sweden)

    Silvia Cristina Mangini Bocchi

    2004-02-01

    Full Text Available Trata-se de trabalho do tipo bibliográfico com a finalidade de fazer uma análise temática da produção do conhecimento em periódicos, acerca da sobrecarga em cuidadores familiares de pessoas com Acidente Vascular Cerebral (AVC. O corpus de análise reuniu artigos localizados nas décadas de 80 e 90, a partir das bases de dados Medline, Lilacs e Cinahl. A análise de conteúdo foi o referencial metodológico que permitiu organizar todo o conhecimento, em um corpo de categorias e subcategorias, denominadas: Categoria 1 - As seqüelas do AVC gerando sobrecarga; Categoria 2 - Aspectos gerando sobrecarga, congregando as subcategorias: o isolamento social, as mudanças e as insatisfações conjugais, as dificuldades financeiras e os déficits na saúde física e no autocuidado do cuidador; Categoria 3 - Outras análises relacionadas à sobrecarga em cuidadores familiares.Se trata de un trabajo del tipo bibliográfico con la finalidad de hacer un análisis temático de producción del conocimiento en revistas, sobre la carga de cuidadores familiares de personas con Accidente Cerebrovascular (ACV. El corpus de análisis reunió artículos realizados en las décadas de 80 y 90 a partir de las bases de datos Medline, Lilacs y Cinahl. El análisis de contenido fue el referencial metodológico que permitió organizar todo el conocimiento en un cuerpo de categorías y subcategorías denominadas: categoría 1 - Las secuelas del ACV generando carga, Categoría 2 - Aspectos generadores de la carga que congregan las subcategorías: el aislamiento social, los cambios y las insatisfacciones conyugales, las dificultades financieras y los déficit en la salud física y en el cuidado consigo mismo, Categoría 3 - Otros análisis sobre la carga de cuidadores familiares de personas con ACV.This bibliographical research aims to carry out a thematic analysis of knowledge production in periodicals, about the burden placed on family caregivers of Cerebrovascular

  13. Modelling of increased homocysteine in ischaemic stroke: post-hoc cross-sectional matched case-control analysis in young patients Aumento de homocisteína em acidente vascular cerebral isquêmico: análise post-hoc com casos controles em pacientes jovens

    Directory of Open Access Journals (Sweden)

    Penka A. Atanassova

    2007-03-01

    Full Text Available BACKGROUND & PURPOSE: Hyperhomocysteinaemia has been postulated to participate in pathogenesis of ischaemic stroke (IS. However, especially in young adults, there is possibility of significantly increased IS risk due to increased ‘normal’ homocysteinaemia, i.e., ‘hidden’ (‘pathologically dormant’ prevalence within a healthy, normally-defined range. We performed a post-hoc modelling investigation on plasma total homocysteinaemia (THCY in gender- and age-matched young patients in the acute IS phase. We evaluated relationships between THCY and prevalence of other potential risk factors in 41 patients vs. 41 healthy controls. METHOD: We used clinical methods, instrumental and neuroimmaging procedures, risk factors examination, total plasma homocysteine measurements and other laboratory and statistical modelling techniques. RESULTS: IS patients and healthy controls were similar not only for matching variables, but also for smoking, main vitamin status, serum creatinine and lipid profile. Patients with IS, however, had lower vitamin B6 levels and higher THCY, fibrinogen and triglycerides (TGL. At multivariate stepwise logistic regression only increased THCY and TGL were significantly and independently associated with the risk for stroke (72% model accuracy, p model=0.001. An increase of THCY with 1.0 µmol/L was associated with 22% higher risk of ischaemic stroke [adjusted OR=1.22 (95%CI 1.03?1.44]. In this way, novel lower cut-off value for HCY of 11.58 µmol/L in younger patients has been revealed (ROC AUC= 0.67, 95CI% 0.55-0.78, p=0.009. CONCLUSION: The new THCY cut-off clearly discriminated between absence and presence of IS (sensitivity>63%, specificity>68% irrespectively of age and gender and may be applied to better evaluate and more precisely define, as earlier as possible, the young patients at increased IS risk.OBJETIVO: Hiperhomocisteinemia tem sido postulada como um dos fatores de risco na patogênese do acidente vascular

  14. Renovascular hypertension causes cerebral vascular remodeling

    Institute of Scientific and Technical Information of China (English)

    Yamei Tang; Xiangpen Li; Yi Li; Qingyu Shen; Xiaoming Rong; Ruxun Huang; Ying Peng

    2011-01-01

    Renovascular hypertensive rats (RHRs) were developed using the 2-kidney, 2-clip method. All RHRs at 10 weeks displayed high permeability of the cerebral surface blood vessels. Vascular casts of the RHRs showed that the vascular network was sparse. The arterioles of the RHRs at 10 weeks had smaller lumen diameters, but thicker vessel walls with hyalinosis formation compared with control animals. The endothelial cell membrane appeared damaged, and microthrombus formed. After ischemia, the infarction size was larger in RHRs than in control animals. These results suggest that cerebral arterioles in RHRs underwent structural remodeling. High blood pressure may aggravate the severity of brain injury in cerebral ischemia and affect the recovery of ischemia.

  15. [Transcranial electrostimulation in chronic cerebral vascular insufficiency].

    Science.gov (United States)

    Voropaev, A A; Mochalov, A D

    2006-01-01

    The method of transcranial electrostimulation (TCES) has been used for treatment of 68 patients with chronic cerebral vascular insufficiency, stages I and II. A treatment course included 7 daily procedures. The influence of TCES was evaluated clinically, by EEG, transcranial ultrasonic Doppler study and hemodynamic indices in arteries and veins as well as by expression of trait and state anxiety. All the parameters were compared to those of the control group which was treated using conventional methods. TCES resulted in normalization of cerebral vascular reactivity, a decrease of venous circulation disturbances, positive influence on cerebral blood flow and EEG parameters, that corresponded to global improvement of the patients' state, regress of cephalgic syndrome and reduction of trait and state anxiety. The method is simple and safety and can be recommended for wide application including outpatient setting.

  16. Ausência de descenso noturno se associa a acidente vascular cerebral e infarto do miocárdio La ausencia de descenso nocturno de la presión arterial se asocia a accidente cerebrovascular e infarto de miocardio Absence of nocturnal dipping is associated with stroke and myocardium infarction

    Directory of Open Access Journals (Sweden)

    Renan Oliveira Vaz-de-Melo

    2010-01-01

    Full Text Available FUNDAMENTO: A pressão arterial (PA varia de acordo com o ciclo circadiano, apresentando quedas fisiológicas durante o sono (descenso noturno - DN. A ausência dessa queda se associa a maior incidência de lesões em órgãos-alvo. OBJETIVO: Analisar a prevalência de DN em indivíduos hipertensos, correlacionar DN aos níveis pressóricos, variáveis clínicas, fatores sociodemográficos e bioquímicos e associá-lo a eventos cardiovasculares (acidente vascular cerebral - AVC e infarto agudo do miocárdio - IAM. MÉTODOS: Foram avaliados 163 hipertensos, submetidos a monitorização ambulatorial da pressão arterial. DN foi definido como queda >10% da PA sistólica do período da vigília para o de sono. RESULTADOS: Os pacientes foram divididos em grupos dipper (D e não dipper (ND. Não houve diferença significante entre os grupos quanto a idade, sexo, raça, tempo de hipertensão, glicemia, LDL-colesterol, colesterol total, triglicérides, escolaridade, tabagismo, história de diabetes. Grupo dipper apresentou PA superior a ND durante a vigília e inferior durante o sono. Grupo ND cursou com maior índice de massa corpórea (IMC (p=0,0377, menor HDL-colesterol (p=0,0189 e maior pressão de pulso durante o sono (p=0,0025. História de AVC ou IAM foram mais frequentes em ND. À regressão logística, apenas a ausência de descenso noturno associou-se independentemente a AVC ou IAM. CONCLUSÃO: A ausência de DN associou-se de maneira independente às lesões em órgãos-alvo analisadas, o que demonstra a sua importância e reforça a necessidade de tratamento mais agressivo com objetivo de se atingir as metas pressóricas e, consequentemente, evitar o desenvolvimento de novos eventos cardiocerebrovasculares.FUNDAMENTO: La presión arterial (PA varía de acuerdo al ciclo circadiano, presentando descensos fisiológicos durante el sueño (descenso nocturno - DN. La ausencia de ese descenso se asocia a mayor incidencia de lesiones en

  17. Advances in the Management of Cerebral Vascular Disease

    OpenAIRE

    Muhammad Imran Qadir; Hina Kanwal

    2015-01-01

    A cerebral vascular disease occurred with the arteries of brain due to the less supply of blood.  Stroke is mostly caused by cerebral vascular disease and it is also a common cause of vascular dementia due to reduced oxygen supply and blood flow to the brain. In industrialized countries, neurologic disability is most frequently caused by cerebeovascular disease. Individuals with cardiovascular disease, diabetes and high blood pressure etc are at higher possibility for cerebral vascular diseas...

  18. Eficácia da fonoterapia em um caso de afasia expressiva decorrente de acidente vascular encefálico

    Directory of Open Access Journals (Sweden)

    Letícia Regina Kunst

    2013-12-01

    Full Text Available O objetivo deste estudo de caso foi relatar e analisar o caso de um paciente afásico adulto em tratamento fonoaudiológico na clínica escola do Curso de Fonoaudiologia de uma instituição federal de ensino. O sujeito estudado é um paciente do sexo masculino, com 68 anos de idade, em tratamento na clínica escola desde maio de 2009, sendo que seu processo terapêutico foi analisado até dezembro de 2010. Quanto à história clínica, o paciente sofreu acidente vascular encefálico isquêmico no hemisfério esquerdo, em janeiro de 2009, quando repentinamente apresentou um quadro de mutismo. Após serem realizadas avaliações fonoaudiológicas, concluiu-se que o mesmo apresentava como hipótese diagnóstica "Afasia de expressão, oral e escrita, decorrente de acidente vascular encefálico isquêmico." Diante disto foi elaborado o planejamento terapêutico. Desde o início do processo de terapia foi possível observar evoluções linguísticas no paciente. O fato de o sujeito ter procurado atendimento fonoaudiológico 15 dias após o acometimento pelo acidente vascular encefálico, provavelmente foi um fator fundamental para sua boa recuperação, pois há um grau de recuperação espontânea em pacientes afásicos, porém a melhora é mínima sem o tratamento adequado. Em aproximadamente um mês de terapia fonoaudiológica, o paciente expandiu consideravelmente seu vocabulário. Apesar de a área lesada ser extensa e fundamental para a linguagem, observou-se avanços bastante positivos com a terapia. Deste modo, acredita-se que a intervenção fonoaudiológica precoce contribuiu, em grande parte, para a reorganização da atividade linguística, visto que o paciente comunica-se satisfatoriamente considerando a grande extensão de sua lesão.

  19. Vascular permeability in cerebral cavernous malformations

    DEFF Research Database (Denmark)

    Mikati, Abdul G; Khanna, Omaditya; Zhang, Lingjiao;

    2015-01-01

    -controlled observational study investigated whether the brains of human subjects with familial CCM show vascular hyperpermeability by dynamic contrast-enhanced quantitative perfusion magnetic resonance imaging, in comparison with CCM cases without familial disease, and whether lesional or brain vascular permeability...... vascular hyperpermeability in humans with an autosomal dominant disease, as predicted mechanistically. Brain permeability, more than lesion permeability, may serve as a biomarker of CCM disease activity, and help calibrate potential drug therapy.......Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo. A prospective case...

  20. Escalas para avaliação da sobrecarga de cuidadores de pacientes com Acidente Vascular Encefálico

    Directory of Open Access Journals (Sweden)

    Ana Railka de Souza Oliveira

    2012-10-01

    Full Text Available O objetivo do estudo foi avaliar as escalas disponíveis na literatura para medir a sobrecarga de cuidadores de pacientes acometidos por acidente vascular encefálico. Realizou-se uma revisão bibliográfica nas três bases de dados: LILACS, CINAHL e SCOPUS. Selecionaram-se 23 trabalhos e identificaram-se 24 diferentes escalas. Destas, as mais citadas foram o Caregiver Strain Index, a Caregiver Burden Scale, a Caregiver Reaction Assessment, o Sense of Competence Questionnaire, a Relatives Stress Scale e a Zarit Burden Interview. O uso de escalas para mensurar a sobrecarga é uma ferramenta importante para avaliar o contexto no qual está inserido o cuidador, entretanto é mais fidedigno quando associado a outros instrumentos de mensuração. Portanto, é fundamental pesquisas de validação de escalas para essa população.

  1. Advances in the Management of Cerebral Vascular Disease

    Directory of Open Access Journals (Sweden)

    Muhammad Imran Qadir

    2015-06-01

    Full Text Available A cerebral vascular disease occurred with the arteries of brain due to the less supply of blood.  Stroke is mostly caused by cerebral vascular disease and it is also a common cause of vascular dementia due to reduced oxygen supply and blood flow to the brain. In industrialized countries, neurologic disability is most frequently caused by cerebeovascular disease. Individuals with cardiovascular disease, diabetes and high blood pressure etc are at higher possibility for cerebral vascular disease. After malignancy and heart disease, cerebral vascular disease is the third leading of death and estimated that an average 500,000 new stroke occurred in each year. Advance techniques such as Carotid Endarterectomy, Magnetic resonance imaging, Angiography and Single photon emission computed tomography etc are used for management of cerebral vascular disease.

  2. Vascular permeability in cerebral cavernous malformations.

    Science.gov (United States)

    Mikati, Abdul G; Khanna, Omaditya; Zhang, Lingjiao; Girard, Romuald; Shenkar, Robert; Guo, Xiaodong; Shah, Akash; Larsson, Henrik B W; Tan, Huan; Li, Luying; Wishnoff, Matthew S; Shi, Changbin; Christoforidis, Gregory A; Awad, Issam A

    2015-10-01

    Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo. A prospective case-controlled observational study investigated whether the brains of human subjects with familial CCM show vascular hyperpermeability by dynamic contrast-enhanced quantitative perfusion magnetic resonance imaging, in comparison with CCM cases without familial disease, and whether lesional or brain vascular permeability correlates with CCM disease activity. Permeability in white matter far (WMF) from lesions was significantly greater in familial than in sporadic cases, but was similar in CCM lesions. Permeability in WMF increased with age in sporadic patients, but not in familial cases. Patients with more aggressive familial CCM disease had greater WMF permeability compared to those with milder disease phenotype, but similar lesion permeability. Subjects receiving statin medications for routine cardiovascular indications had a trend of lower WMF, but not lesion, permeability. This is the first demonstration of brain vascular hyperpermeability in humans with an autosomal dominant disease, as predicted mechanistically. Brain permeability, more than lesion permeability, may serve as a biomarker of CCM disease activity, and help calibrate potential drug therapy.

  3. [Neurourological signs of chronic cerebral vascular diseases].

    Science.gov (United States)

    Shvarts, P G; Dutov, V V; Kadykov, A S; Shvedkov, V V; Popov, S V; Plotnikov, A N

    2013-01-01

    Disorders of urination, along with motor and cognitive disorders, are characteristic of different forms of chronic cerebral vascular diseases (CCVD). Irritation symptoms are more frequent in subcortical arteriosclerotic encephalopathy (SAE) and multi infarct hypertonic encephalopathy (MIHE). Overactive urine bladder syndrome (OUBS) caused by neurogenic detrusive hyperactivity manifests itself in frequent urination, nocturia and imperative enuresis and thus decreases quality of life and results in disability of patents with CCVD. At the same time, the character of symptoms points indirectly to the localization of lacunar infarction or the extent of severity of leukoareosis. It is the most frequent form of disorders of urination in the first years of disease that significantly aggravates its course and needs timed diagnosis and pharmacological treatment. Competitive antagonists of muscarinic receptors M2, M3 subtypes are the most effective drugs for treatment of OUBS comorbid to CCVD. PMID:23994932

  4. Análise de terapias coadjuvantes de intervenção terapêutica na funcionalidade em doentes com acidente vascular encefálico

    OpenAIRE

    Sousa, João Paulo de

    2015-01-01

    Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciado em Fisioterapia Objectivo: Analisar as diferentes terapias coadjuvantes de intervenção terapêutica na funcionalidade de doentes com Acidente Vascular Encefálico (AVE). Metodologia: Foi realizada uma pesquisa nas bases de dados PubMed e PEDro. Foram utilizadas as palavras-chave: “stroke”, “physical therapy” e “outcome FIM”. Resultado: Obtiveram-se 144 estudos, após a...

  5. Cuidados Paliativos: o necessário para o idoso com acidente vascular encefálico

    Directory of Open Access Journals (Sweden)

    Sônia Maria Dorta Ferreira

    2014-03-01

    Full Text Available A expectativa de vida do ser humano tem aumentado nas últimas décadas, o que vem exigindo o avanço da qualidade dos cuidados destinados a pessoas com fragilidades, especialmente em decorrência do crescimento considerável das doenças crônicas. Dentre essas doenças, destaca-se o acidente vascular encefálico (AVE que acomete grande parte da população idosa, ocasionando perdas e sequelas significativas. Formas inovadoras quanto à essência do cuidar devem ser estudadas e praticadas em nossa sociedade, reconhecendo-se como exemplar nesse sentido a intervenção em cuidados paliativos, que pode melhorar a qualidade de vida e confortar uma pessoa nos seus últimos dias. Nessa direção, objetiva este trabalho enfatizar a necessidade e o valor dos cuidados paliativos para a pessoa idosa com AVE e, para tal, foi realizado um levantamento da pesquisa científica sobre a temática nas principais revistas indexadas. Os resultados indicaram um número limitado de produção científica a esse respeito, assim como se verifica a escassez de serviços que assistam os idosos no final da vida, evidenciando ainda o desconhecimento dos serviços de cuidados paliativos à maior parte dos doentes e suas famílias. Os dados mostram que são múltiplos os sintomas físicos e psicológicos que comprometem a qualidade de vida dessas pessoas em terminalidade, e que a comunicação é essencial nas relações entre paciente, cuidador, família e equipe de saúde. No caso de idosos com AVE, a presença dos Cuidados Paliativos torna-se ainda mais relevante na relação desses pacientes com familiares e outros profissionais. Trabalhos futuros envolvendo os variados aspectos dos Cuidados Paliativos são necessários, para que se possa assegurar um atendimento mais competente e efetivo a essa população.

  6. Associação entre acidentes vasculares encefálicos e doença de Chagas

    Directory of Open Access Journals (Sweden)

    Edison Reis Lopes

    1991-06-01

    Full Text Available Foi pesquisada a freqüência de acidentes vasculares encefálicos (A VE, isquêmicos e hemorrágicos, em chagásicos crônicos e em não chagásicos, maiores de 15 anos de idade, necropsiados em Uberaba, de 1979 a 1988, optando-se por estudo emparelhado por sexo e idade em 208 pares. Em 41 (19,7% dos chagásicos e em 55 (26,4% dos não chagásicos foram diagnosticados AVE, diferença não significante ao nível de 5%. Dos chagásicos 12 (75% tiveram infarto e 4 (25% hemorragia encefálica; dos não chagásicos 5 (31,3% tiveram infarto e 11 (68,7% hemorragia. As .diferenças são significantes ao nível de 5%. Os resultados demonstram menor freqüência de AVE hemorrágico em chagásicos que em não chagásicos e comprovam alta freqüência de AVE isqüêmico na doença de Chagas humana.The frequency of strokes was studied in chronic chagasic and years ofage, non-chagasicpatients, older than 15 coming to necropsy in Uberaba, from 1979 than 1988. The study consisted of paired sex and age matched controls. Two hundred and eight pairs were analysed. Either ischemic or hemorrhagic strokes were found in 41 (19,7% of the chagasics and in 55 (26.4% of the non-chagasic, a difference not significant at the level of 5%. Twelve (75% of the former had infarcts and 4(25% had brain hemorrhage; five (31,3% of the non-chagasics had ischemic strokes and 11 (68,7% had hemorrhagic strokes. The differences were significant to the level of 5%. The results indicate a high frequency of ischemic strokes in human Chagas'disease and demonstrate a lesser frequency of hemorrhagic stroke in chagasics when compared with non-chagasics.

  7. Cerebral vascular control and metabolism in heat stress

    DEFF Research Database (Denmark)

    Bain, Anthony R; Nybo, Lars; Ainslie, Philip N

    2015-01-01

    This review provides an in-depth update on the impact of heat stress on cerebrovascular functioning. The regulation of cerebral temperature, blood flow, and metabolism are discussed. We further provide an overview of vascular permeability, the neurocognitive changes, and the key clinical implicat...... thermoregulatory control-for example, spinal cord injury, elderly, and those with preexisting cardiovascular diseases. © 2015 American Physiological Society. Compr Physiol 5:1345-1380, 2015.......This review provides an in-depth update on the impact of heat stress on cerebrovascular functioning. The regulation of cerebral temperature, blood flow, and metabolism are discussed. We further provide an overview of vascular permeability, the neurocognitive changes, and the key clinical...... peripheral resistance secondary to skin vasodilatation. Therefore, when hyperthermia is combined with conditions that increase cardiovascular strain, for example, orthostasis or dehydration, the inability to preserve cerebral perfusion pressure further reduces CBF. A reduced cerebral perfusion pressure...

  8. Occupational performance and satisfaction of individuals after cerebral vascular accident

    OpenAIRE

    Kátia Vanessa Pinto de Meneses; Ana Carolina dos Santos Pereira; Vanessa de Oliveira Alencar; Jeanine Schuabb Duarte

    2014-01-01

    Introduction: Scientific studies show that occupational therapy interventions with patients after cerebral vascular accident (CVA) - post-stroke patients, help them resume the performance of important meaningful tasks. Objective: To measure changes in the perception of post-stroke patients on their occupational performance and satisfaction after the intervention of occupational therapy. Methodology: An observational, longitudinal, prospective study with CVA patients treated at occupational...

  9. Atividade muscular durante a marcha após acidente vascular encefálico Muscle activity during gait following stroke

    OpenAIRE

    Fernanda Ishida Corrêa; Flávia Soares; Daniel Ventura Andrade; Ricardo Mitsuo Gondo; José Augusto Peres; Antônio Olival Fernandes; João Carlos Ferrari Corrêa

    2005-01-01

    OBJETIVO: Buscar parâmetros da marcha de pacientes após ter sofrido acidente vascular encefálico (AVE) com hemiparesia. MÉTODO: Comparados 15 voluntários pós-AVE e 15 voluntários saudáveis com a mesma idade, gênero e peso. A comparação foi feita por eletromiografia utilizando cinco pares de eletrodos de superfície do lado comprometido (espástico) e um eletrogoniômetro sobre o eixo articular de rotação da articulação do tornozelo em estudo. RESULTADOS: O início da atividade eletromiográfica, a...

  10. Erythropoietin and cerebral vascular protection: role of nitric oxide

    Institute of Scientific and Technical Information of China (English)

    Anantha Vijay R SANTHANAM; Zvonimir S KATUSIC

    2006-01-01

    Cerebral vasospasm after subarachnoid hemorrhage (SAH) is a major clinical problem causing cerebral ischemia and infarction.The pathogenesis of vasospasm is related to a number of pathological processes including endothelial damage and alterations in vasomotor function leading to narrowing of artefial diameter and a subsequent decrease in cerebral blood flow.Discovery of the tissue protective effects of erythropoietin (EPO) stimulated the search for therapeutic application of EPO for the prevention and treatment of cerebrovascular disease.Recent studies have identified the role of EP0 in vascular protection mediated by the preservation of endothelial cell integrity and stimulation of angiogenesis.In this review, we discuss the EPO-induced activation of endothelial nitric oxide (NO) synthase and its contribution to the prevention of cerebral vasospasm.

  11. Studies on Treatment of Cerebral Vascular Disease with Integrative Medicine

    Institute of Scientific and Technical Information of China (English)

    孙怡; 韩景献; 谢道珍; 李如奎; 高利; 许健鹏

    2003-01-01

    @@Cerebral vascular disease (CVD) also called the cerebral stroke or wind stroke. There are two common types in clinic, that is, thrombotic CVD and hemorrhagic CVD. CVD has both a high incidence rate and a high mortality rate. It has become the most dangerous factor that costs the lives of the urban population in our country. People of different age groups can develop this kind of disease, and the morbidity rate increases dramatically for those middle-aged in recent years. At present, the harms done by CVD to the human heath are more prominent.

  12. Role of Mitochondria in Cerebral Vascular Function: Energy Production, Cellular Protection, and Regulation of Vascular Tone.

    Science.gov (United States)

    Busija, David W; Rutkai, Ibolya; Dutta, Somhrita; Katakam, Prasad V

    2016-06-13

    Mitochondria not only produce energy in the form of ATP to support the activities of cells comprising the neurovascular unit, but mitochondrial events, such as depolarization and/or ROS release, also initiate signaling events which protect the endothelium and neurons against lethal stresses via pre-/postconditioning as well as promote changes in cerebral vascular tone. Mitochondrial depolarization in vascular smooth muscle (VSM), via pharmacological activation of the ATP-dependent potassium channels on the inner mitochondrial membrane (mitoKATP channels), leads to vasorelaxation through generation of calcium sparks by the sarcoplasmic reticulum and subsequent downstream signaling mechanisms. Increased release of ROS by mitochondria has similar effects. Relaxation of VSM can also be indirectly achieved via actions of nitric oxide (NO) and other vasoactive agents produced by endothelium, perivascular and parenchymal nerves, and astroglia following mitochondrial activation. Additionally, NO production following mitochondrial activation is involved in neuronal preconditioning. Cerebral arteries from female rats have greater mitochondrial mass and respiration and enhanced cerebral arterial dilation to mitochondrial activators. Preexisting chronic conditions such as insulin resistance and/or diabetes impair mitoKATP channel relaxation of cerebral arteries and preconditioning. Surprisingly, mitoKATP channel function after transient ischemia appears to be retained in the endothelium of large cerebral arteries despite generalized cerebral vascular dysfunction. Thus, mitochondrial mechanisms may represent the elusive signaling link between metabolic rate and blood flow as well as mediators of vascular change according to physiological status. Mitochondrial mechanisms are an important, but underutilized target for improving vascular function and decreasing brain injury in stroke patients. © 2016 American Physiological Society. Compr Physiol 6:1529-1548, 2016.

  13. Role of Mitochondria in Cerebral Vascular Function: Energy Production, Cellular Protection, and Regulation of Vascular Tone.

    Science.gov (United States)

    Busija, David W; Rutkai, Ibolya; Dutta, Somhrita; Katakam, Prasad V

    2016-01-01

    Mitochondria not only produce energy in the form of ATP to support the activities of cells comprising the neurovascular unit, but mitochondrial events, such as depolarization and/or ROS release, also initiate signaling events which protect the endothelium and neurons against lethal stresses via pre-/postconditioning as well as promote changes in cerebral vascular tone. Mitochondrial depolarization in vascular smooth muscle (VSM), via pharmacological activation of the ATP-dependent potassium channels on the inner mitochondrial membrane (mitoKATP channels), leads to vasorelaxation through generation of calcium sparks by the sarcoplasmic reticulum and subsequent downstream signaling mechanisms. Increased release of ROS by mitochondria has similar effects. Relaxation of VSM can also be indirectly achieved via actions of nitric oxide (NO) and other vasoactive agents produced by endothelium, perivascular and parenchymal nerves, and astroglia following mitochondrial activation. Additionally, NO production following mitochondrial activation is involved in neuronal preconditioning. Cerebral arteries from female rats have greater mitochondrial mass and respiration and enhanced cerebral arterial dilation to mitochondrial activators. Preexisting chronic conditions such as insulin resistance and/or diabetes impair mitoKATP channel relaxation of cerebral arteries and preconditioning. Surprisingly, mitoKATP channel function after transient ischemia appears to be retained in the endothelium of large cerebral arteries despite generalized cerebral vascular dysfunction. Thus, mitochondrial mechanisms may represent the elusive signaling link between metabolic rate and blood flow as well as mediators of vascular change according to physiological status. Mitochondrial mechanisms are an important, but underutilized target for improving vascular function and decreasing brain injury in stroke patients. © 2016 American Physiological Society. Compr Physiol 6:1529-1548, 2016. PMID:27347901

  14. Acupuncture Treatment of Depressive Syndromes after Cerebral Vascular Accidents

    Institute of Scientific and Technical Information of China (English)

    王海荣

    2002-01-01

    @@ Depressive syndrome is a common complication in cerebral vascular accidents (CVA), which accounts for 70% of the complications. A mild case of the syndrome is marked by grief, sleeping disturbance, weakened mental activities, worry, loss of interest, and irritability. A severe case may have worse symptoms and signs, except the above mentioned ones, such as anxiety, reduced appetite, hallucination, delusion, desperation, etc. The author has adopted acupuncture to treat depressive syndromes after CVA with good therapeutic result as reported in the following.

  15. Pathogenesis of diabetic cerebral vascular diseasecomplication

    Institute of Scientific and Technical Information of China (English)

    Ren-Shi Xu

    2015-01-01

    Diabetes mellitus is one of the most potent independentrisk factors for the development of diabetic cerebralvascular disease (CVD). Many evidences suggested thathyperglycemia caused excess free fatty acids, the lossof endothelium-derived nitric oxide, insulin resistance,the prothrombotic state, endothelial dysfunction,the abnormal release of endothelial vasoactivators,vascular smooth muscle dysfunction, oxidative stress,and the downregulation of miRs participated in vesselgeneration and recovery as well as the balance ofendotheliocytes. In turn, these abnormalities, mainly viaphosphatidylinositol 3 kinase, mitogen-activated proteinkinase, polyol, hexosamine, protein kinase C activation,and increased generation of advanced glycosylation endproducts pathway, play an important role in inducingdiabetic CVD complication. A deeper comprehensionof pathogenesis producing diabetic CVD could offerbase for developing new therapeutic ways preventingdiabetic CVD complications, therefore, in the paper wemainly reviewed present information about the possiblepathogenesis of diabetic CVD complication.

  16. Atuação da enfermagem no autocuidado e reabilitação de pacientes que sofreram Acidente Vascular Encefálico

    Directory of Open Access Journals (Sweden)

    Juliana Cristina Lessmann

    2011-02-01

    Full Text Available Quando o cérebro sofre alterações vasculares podem ocorrer sérias sequelas motoras, sensoriais e na percepção. Nesta perspectiva o estudo objetiva relatar/ compartilhar assistência de Enfermagem ao indivíduo acometido pelo Acidente Vascular Encefálico enfatizando a reabilitação e o autocuidado baseado em Orem. Trata-se de relato de experiência de prática assistencial, realizada de maio a julho de 2006, com 15 indivíduos e seus familiares, em um centro de reabilitação da região sul do Brasil. O cuidado de Enfermagem integral ocorre com atividades de estimulação sensitiva, motora, controle postural, amplitude de movimentos e treino de marcha, sempre acompanhados por ações de educação em saúde. Estas habilidades conferem aos enfermeiros capacidades de atuação proporcionando a redução de danos e incapacidades

  17. Monitoring cerebral oxygenation in a pediatric patient undergoing surgery for vascular ring.

    Science.gov (United States)

    Joshi, Reena K; Motta, Pablo; Horibe, Mayumi; Mossad, Emad

    2006-02-01

    Regional cerebral oxygenation can be monitored using near-infrared spectroscopy (NIRS). Inadequacy of collateral cerebral circulation and regional cerebral ischemia during cardiac and vascular surgery may be detected by the use of NIRS monitoring. We report a 2-year-old child who underwent surgical repair of vascular ring and subclavian reimplantation, where use of NIRS helped in early detection and timely intervention to prevent prolonged cerebral ischemia. PMID:16430416

  18. Cerebral angiography, blood flow and vascular reactivity in progressive hypertension

    Science.gov (United States)

    Li, Yunxia; Shen, Qiang; Huang, Shiliang; Li, Wei; Muir, Eric R.; Long, Justin; Duong, Timothy Q.

    2015-01-01

    Chronic hypertension alters cerebral vascular morphology, cerebral blood flow (CBF), cerebrovascular reactivity, increasing susceptibility to neurological disorders. This study evaluated: i) the lumen diameters of major cerebral and downstream arteries using magnetic resonance angiography, and ii) basal CBF, and iii) cerebrovascular reactivity to hypercapnia of multiple brain regions using arterial-spin-labeling technique in spontaneously hypertensive rats (SHR) at different stages. Comparisons were made with age-matched normotensive Wistar Kyoto (WKY) rats. In 10-week SHR, lumen diameter started to reduce, basal CBF, and hypercapnic CBF response were higher from elevated arterial blood pressure, but there was no evidence of stenosis, compared to age-matched WKY. In 20-week SHR, lumen diameter remained reduced, CBF returned toward normal from vasoconstriction, hypercapnic CBF response reversed and became smaller, but without apparent stenosis. In 40-week SHR, lumen diameter remained reduced and basal CBF further decreased, resulting in larger differences compared to WKY. There was significant stenosis in main supplying cerebral vessels. Hypercapnic CBF response further decreased, with some animals showing negative hypercapnic CBF responses in some brain regions, indicative of compromised cerebrovascular reserve. The territory with negative hypercapnia CBF responses corresponded with the severity of stenosis in arteries that supplied those territories. We also found enlargement of downstream vessels and formation of collateral vessels as compensatory responses to vasoconstriction upstream vessels. The middle cerebral and azygos arteries were amongst the most susceptible to hypertension-induced changes. Multimodal MRI provides clinically relevant data that might be useful to characterize disease pathogenesis, stage disease progression, and monitor treatment effects in hypertension. PMID:25731987

  19. Categorical course in neuroradiology cerebral ischemia, hemorrhage, and vascular lesions

    International Nuclear Information System (INIS)

    The diagnostic imaging of acute stroke is primarily directed toward identifying the lesion, characterizing it as either intracranial hemorrhage or ischemia, and assessing the anatomic extent of the lesion. The acute medical or surgical management decisions are best aided by a combination of CT and cerebral angiography, the latter used acutely mostly for intracranial hemorrhage, especially subarachnoid hemorrhage. More complex presentations benefit from MR imaging evaluation as well. After the acute phase, the main goal of treatment, especially for patients who have had reasonable recovery from the acute stroke, is the prevention of recurrent, and perhaps more severe, stroke. Treatments such as aneurysm clipping or arteriovenous malformation removal for hemorrhagic lesions, or anticoagulation or carotid endarterectomy for ischemic lesions, require brain and vascular imaging studies for appropriate treatment planning. Angiography to show the anatomic vascular cause for the bleed or ischemia is therefore usually a requirement. The enlarging experience with MR imaging has contributed greatly to the identification of occult vascular lesions of the brain that may be prone to bleeding and to recognizing blood in the brain accurately. For this purpose MR imaging is sometimes more specific than CT

  20. Value of cerebral perfusion and vascular reserve for the treatment of symptomatic intracranial arterial stenosis

    Institute of Scientific and Technical Information of China (English)

    Li'an Huang; Xuewen Song; Anding Xu

    2008-01-01

    BACKGROUND: It is crucial to understand cerebral perfusion and vascular reserve in stegnotic arterial blood-supply regions to treat ischemic cerebrovascular diseases. However, effects on symptomatic intracrani-al arterial stenosis (SICAS) need to be further studied in additional applications. OBJECTIVE: To evaluate and summarize the effects of cerebral perfusion and vascular reserve on the treatment of SICAS. RETRIEVAL STRATEGY: A computer-based online search of English language publications from January 2000 to July 2007 was conducted in PubMed to identify publications that addressed cerebral perfusion and vascular reserve of SICAS. Search key words were "intracranial stenosis, perfusion, brain reserve". Relevant data were also searched with the China Journal Net, using the same key words in Chinese from January 2000 to January 2007. In total, 101 articles were retrieved. Inclusion criteria: ① Articles describing the current status for the diagnosis and treatment of SICAS; ② Articles concerning research developments of cerebral perfusion and vascular reserve of SICAS. Exclusion criteria: duplicated articles. LITERATURE EVALUATION: This study included 21 articles of experimental studies and conference re-ports.DATA SYNTHESIS: When performing interventional surgery in SICAS patients, it is important to under-stand cerebral perfusion and vascular reserve in addition to knowing the clinical symptoms and degrees of arterial stenosis. In recent years, there are a growing number of reports on measurements of vascular reserve through the use of magnetic resonance perfusion imaging (MR-PWI). Investigations demonstrate cerebral perfusion and vascular reserve decrease in many SICAS patients. Many studies show that both improve after surgical intervention. CONCLUSION: Cerebral perfusion could provide direct evidence of whether ischemia has occurred in the brain. Because of lateral circulation and cerebral vascular reserve, intracranial vascular stenosis and/or decreased

  1. Desarrumou tudo!O impacto do acidente vascular encefálico na família It changed everything! The impact of the stroke on the family

    Directory of Open Access Journals (Sweden)

    Eliana Sales Brito

    2008-06-01

    Full Text Available O acidente vascular encefálico (AVE resulta em déficits neurológicos temporários ou permanentes, de variadas intensidades, que podem comprometer a independência do indivíduo acometido na realização de atividades de vida diária. Este estudo de caso investigou famílias de pacientes com diagnóstico de AVE, buscando compreender as dificuldades de ordem estrutural, socioeconômica e emocional pelas quais elas passam; a relação entre o grau de severidade de agravo, tempo de ocorrência da doença e o desenvolvimento de estratégias de proteção e cuidado ao familiar doente. Foram utilizados como instrumentos de coleta de dados: questionário; roteiro de entrevista; observações registradas em diário de pesquisa; aplicação do Índice de Barthel, escala de avaliação funcional internacionalmente validada. A análise dos dados foi realizada pelo Discurso do Sujeito Coletivo, produzindo representações sociais e idéias centrais. Constatou-se que a família passa por um processo de transformação que implica em reorganização e adoção de estratégias de enfrentamento favorecidas pela existência de uma rede de suporte. Esses resultados apontam para a necessidade de se habilitar a família para o cuidado ao paciente com incapacidade decorrente de acidente vascular encefálico e para o autocuidado.Strokes (cerebrovascular accidents result in temporal or permanent neurological deficits of varied intensities that can endanger the victim's independency in performing everyday activities. This qualitative case study investigated the families of patients with diagnosis of stroke, in order to understand the structural, socioeconomic and emotional difficulties that they face, and the relationship between the degree of damage severity, the time of disease occurrence and the development of strategies for the relative's protection and care. Data collection instruments were: questionnaire; interview guide; observations registered in a research

  2. Arterioles in cerebral amyloid angiopathy and vascular dementia

    Institute of Scientific and Technical Information of China (English)

    ZHU Guang-ming; ZHANG Wei-wei; LIU Ying; LI Juan

    2009-01-01

    Background Small cerebrovascular lesions are one of the most important factors in cerebral amyloid angiopathy (CM) and vascular dementia (VaD). We analyzed the difference of arteriolar pathology between CM patients (CMs) and vascular dementia patients without CAA (VaDs).Methods Ten deceased CMs and twelve deceased VaDs were available for this study. Five deceased patients without known cerebrovascular diseases served as controls. These patients were all autopsy cases. All transversely cut arterioles in the gray matter and white matter with an external diameter equal to or larger than 30 μm and with a maximum of 300 μm were examined. The internal and external diameters of arterioles were measured. Results The external diameter of gray matter arterioles in the CAAs was significantly greater than in controls. In gray matter arterioles, the diameter of the lumen in VaDs was markedly smaller than in the CAAs, whereas there was no significant difference between CAAs and controls. CMs and VaDs may cause remarkable thickening of the arteriolar walls in either white matter or gray matter. The sclerotic index of arterioles in VaDs was significantly greater than in CAAs and controls. Conclusions Stenosis of arterioles occurred in both CM and VaD, but the tendency was greater in VaD. Arterioles of CM were also expanded in gray matter, which may be related to lobar hemorrhage. The loss and/or degeneration of vascular smooth muscle cells was predominant in CM, while the over-proliferation of vascular smooth muscle cells was greater in VaD.

  3. A família também adoece!: mudanças secundárias à ocorrência de um acidente vascular encefálico na família

    OpenAIRE

    Eliana Sales Brito; Elaine Pedreira Rabinovich

    2008-01-01

    Este estudo buscou compreender o impacto da doença incapacitante na família de pacientes vítimas de acidente vascular encefálico (AVE), investigando as mudanças de ordem estrutural, social e emocional. Foram analisadas nove famílias de pacientes com primeiro episódio de AVE identificados pelo registro geral de doenças do Hospital São Rafael, Salvador, Bahia. A coleta dos dados foi realizada mediante aplicação de questionário, roteiro de entrevista, escala de avaliação funcional e observações ...

  4. ESTUDOS SOBRE ABORDAGENS TERAPÊUTICAS PARA O ACIDENTE VASCULAR ENCEFÁLICO (AVE) EM MODELO ANIMAL: USO DE CÉLULAS DERIVADAS DE MEDULA ÓSSEA E DE FLAVONOIDES

    OpenAIRE

    Arthur Giraldi-Guimarães; Maria de Fátima dos Santos Sampaio; Amélia Miranda Gomes Rodrigues; Helder Teixeira de Freitas; Viviane Gomes da Silva; Fralini dos Santos Marcilio; Bárbara de Paula Coelho; Mayara de Almeida Martins Soares; Mariana Gomes Rebel

    2012-01-01

    O Acidente Vascular Encefálico é a maior causa de incapacitação em seres humanos adultos, representandoatualmente um grande custo pessoal e social. Empregando modelos experimentais de lesões cerebrais focais,este projeto tem como objetivo geral avaliar o efeito benéfico de abordagens terapêuticas promissoras notratamento do AVE e de outras lesões cerebrais. Em estudos concluídos, tivemos como objetivo principalavaliar a capacidade de indução de recuperação funcional em testes sensorimotores p...

  5. Estudo clínico e videofluoroscópico da disfagia na fase subaguda do acidente vascular encefálico Clinical and videofluoroscopic study of dysphagia in patients with cerebrovascular accident in the subacute phase

    OpenAIRE

    Denise Rodrigues Xerez; Yonatta Salarini Vieira Carvalho; Milton Melciades Barbosa Costa

    2004-01-01

    OBJETIVO: Correlacionar, em pacientes portadores de acidente vascular encefálico (AVE) na fase subaguda, as alterações clínicas da deglutição com as observadas na videofluoroscopia. MATERIAIS E MÉTODOS: De 37 portadores de AVE subagudo confirmado por exame de imagem, 26 pacientes de ambos os sexos, com idade média de 59,69 anos, foram avaliados clínica e videofluoroscopicamente. Consideramos como variáveis para pareamento estatístico os parâmetros clínicos indicativos de penetração/aspiração ...

  6. Hospitalização por acidente vascular encefálico isquêmico no Brasil: estudo ecológico sobre possível impacto do Hiperdia

    OpenAIRE

    Johnnatas Mikael Lopes; Gerônimo José Bouzas Sanchis; Jovany Luiz Alves de Medeiros; Fábio Galvão Dantas

    2016-01-01

    RESUMO: Objetivo: O estudo avaliou a tendência de hospitalização por acidente vascular encefálico isquêmico (HAVEI) e a sua mortalidade hospitalar no Brasil nos últimos 15 anos, assim como o impacto do programa Hiperdia nesse cenário. Métodos: Delineou-se um estudo ecológico com abordagem analítica e dados coletados no Sistema de Internação Hospitalar sobre episódios de AVEI, referentes aos anos de 1998 a 2012. Todos os dados foram estratificados por sexo e faixa etária, criando-se um indi...

  7. Avaliação da capacidade funcional de idosos com acidente vascular encefálico Evaluación de la capacidad funcional de adultos mayores con accidente vascular encefálico Evaluation of functional capaciy in elders with encephalic vascular accident

    OpenAIRE

    Keila Cristianne Trindade da Cruz; Maria José D'Elboux Diogo

    2009-01-01

    OBJETIVO: Avaliar a capacidade funcional de idosos com acidente vascular encefálico (AVE) e verificar a relação, bem como a influência de variáveis sociodemográficas e de saúde na capacidade funcional desses sujeitos. MÉTODOS: Foram realizadas entrevistas com 44 idosos, vítimas de AVE, durante o atendimento nos locais de coleta de dados. O instrumento de coleta de dados contemplou dados sociodemográficos e clínicos. Para avaliar a capacidade funcional dos sujeitos foi aplicado o instrumento d...

  8. Estudo clínico e videofluoroscópico da disfagia na fase subaguda do acidente vascular encefálico

    Directory of Open Access Journals (Sweden)

    Xerez Denise Rodrigues

    2004-01-01

    Full Text Available OBJETIVO: Correlacionar, em pacientes portadores de acidente vascular encefálico (AVE na fase subaguda, as alterações clínicas da deglutição com as observadas na videofluoroscopia. MATERIAIS E MÉTODOS: De 37 portadores de AVE subagudo confirmado por exame de imagem, 26 pacientes de ambos os sexos, com idade média de 59,69 anos, foram avaliados clínica e videofluoroscopicamente. Consideramos como variáveis para pareamento estatístico os parâmetros clínicos indicativos de penetração/aspiração e sua confirmação na videofluoroscopia. RESULTADOS: Identificamos disfagia em 19 (73% dos 26 pacientes que fizeram videofluoroscopia; dez (38,46% apresentaram penetração/aspiração de líquidos. Os dados resultantes mostraram não existir correlação (p < 0,05 entre a presença de disfagia e/ou disartria e a presença de penetração/aspiração de líquidos na videofluoroscopia. Houve correlação entre a presença de penetração/aspiração de líquidos observados na videofluoroscopia com os seguintes parâmetros clínicos: estado dos dentes (p = 0,047, mobilidade (p = 0,019 e sensibilidade da face (p = 0,039 e mobilidade da língua (p = 0,012. CONCLUSÃO: Não foi possível definir a presença de penetração/aspiração de líquidos nas vias aéreas por dados epidemiológicos do AVE. A existência de mau estado de preservação dos dentes, alterações na mobilidade da face e da língua e na sensibilidade da face mostrou risco aumentado de penetração/aspiração para líquidos. Permanece importante a indicação da videofluoroscopia para melhor avaliação dos quadros de disfagia após AVE.

  9. Avaliação da aptidão cardiopulmonar em indivíduos com hemiparesia após acidente vascular encefálico

    Directory of Open Access Journals (Sweden)

    Angélica Cristiane Ovando

    2011-02-01

    Full Text Available FUNDAMENTO: Devido à hemiparesia, a avaliação da aptidão cardiorrespiratória de indivíduos após acidente vascular encefálico (AVE, por meio de testes ergométricos com protocolos convencionais, tem se tornado um desafio. OBJETIVO: Realizar teste cardiopulmonar (TCP em hemiparéticos para uma avaliação pré-participação visando uma criteriosa prescrição de exercício aeróbico. MÉTODOS: Participaram do estudo 8 indivíduos com hemiparesia crônica, que foram submetidos a TCP realizado com protocolo individualizado em rampa, desenvolvido a partir da informação da velocidade de marcha dos indivíduos previamente avaliados em teste de pista. Foi considerada a proposta de inclinação variando entre 0 e 10,0%, velocidade inicial correspondente a 70,0% do ritmo de caminhada confortável e velocidade máxima 40,0% superior à velocidade máxima no teste de pista, na expectativa de que o TCP, com este incremento gradativo e constante da intensidade, durasse entre 6 e 8 minutos. RESULTADOS: Em 100,0% dos avaliados, o motivo para a interrupção do teste foi fadiga periférica. O VO2 de pico alcançado foi de 20,6 ± 5,7 ml/kg.min. O Limiar I foi identificado em todos os exames, situando-se em 82,64 ± 4,78% da FC de pico e 73,31 ± 4,97% do VO2 de pico. O quociente respiratório (R do grupo foi de 0,96 ± 0,09, e três dos 8 indivíduos (37,5% atingiram R superior a 1,00, sendo o Limiar II identificado nestes sujeitos. Foram encontradas relações positivas entre variáveis do TCP e escores de equilíbrio, desempenho no teste de caminhada de 6 minutos e velocidade de marcha no solo. CONCLUSÃO: O teste mostrou ser útil para prescrição de atividade física nesses indivíduos.

  10. Correction of vegetative-vascular regulation in cerebral palsy by means of sports games.

    Directory of Open Access Journals (Sweden)

    Kucherov D.S.

    2011-08-01

    Full Text Available The peculiarities of the physical rehabilitation of sports facilities aimed at correcting the condition of vegetative-vascular regulation of children with cerebral palsy at the age of 11-13 years. The results of heart rate variability. The positive effects of the application of physical rehabilitation with elements of sports in children with cerebral palsy, effective changes in the state of vegetative-vascular regulation and improvement of cardiac regulation.

  11. Occupational performance and satisfaction of individuals after cerebral vascular accident

    Directory of Open Access Journals (Sweden)

    Kátia Vanessa Pinto de Meneses

    2014-12-01

    Full Text Available Introduction: Scientific studies show that occupational therapy interventions with patients after cerebral vascular accident (CVA - post-stroke patients, help them resume the performance of important meaningful tasks. Objective: To measure changes in the perception of post-stroke patients on their occupational performance and satisfaction after the intervention of occupational therapy. Methodology: An observational, longitudinal, prospective study with CVA patients treated at occupational therapy service at the ‘Unidade Mista de Taguatinga’, Federal District, Brazil. The Canadian Occupational Performance Measure (COPM was applied in three distinct times: during the initial assessment (time 1, after 3 months (time 2, and after 6 months (time 3 of occupational therapy intervention. Results: The analysis after 3 months of intervention was performed with 17 patients; all showed increased performance scores (p = 0.000, and only one patient presented decrease in satisfaction scores. The analysis after 6 months was conducted with 13 patients; all showed significant improvement (p = 0.000 in scores for performance and satisfaction. Conclusions: The study shows the improvement in satisfaction and occupational performance of CVA patients after occupational therapy intervention. The study suggests that occupational therapy intervention helps the rehabilitation process of post-stroke patients, enabling them to improve their occupational performance and satisfaction and, consequently, their independence.

  12. Cerebral vascular effects of hypovolemia and dopamine infusions

    DEFF Research Database (Denmark)

    Holst Hahn, Gitte; Heiring, Christian; Pryds, Ole;

    2012-01-01

    Despite widespread use, effects of volume boluses and dopamine in hypotensive newborn infants remain controversial. We aimed to elucidate if hypovolemia alone impairs cerebral autoregulation (CA) and if dopamine affects cerebral vasculature.......Despite widespread use, effects of volume boluses and dopamine in hypotensive newborn infants remain controversial. We aimed to elucidate if hypovolemia alone impairs cerebral autoregulation (CA) and if dopamine affects cerebral vasculature....

  13. Percepção de sabores em pacientes com acidente vascular encefálico Taste perception in stroke patients

    Directory of Open Access Journals (Sweden)

    Leda Maria Tavares Alves

    2011-12-01

    Full Text Available OBJETIVO: avaliar a percepção dos sabores amargo, azedo, doce e neutro. MÉTODO: foram estudados 36 pacientes com Acidente Vascular Encefálico (AVE (5 hemorrágicos e 31 isquêmicos e 30 sujeitos controles. Foi realizada avaliação fonoaudiológica estrutural e funcional incluindo postura, vedamento labial, presença de resíduos, tosse, engasgo, e ausculta cervical. Cada sujeito deglutiu em sequência aleatória 5 mL de líquido com os 4 sabores [chá de boldo (amargo, suco de limão diluído (azedo, sacarose diluída (doce e água (neutro] na temperatura ambiente. Entre as deglutições os participantes eram questionados sobre a dificuldade em deglutir e qual o sabor do líquido daquela deglutição. RESULTADOS: entre os pacientes houve maior freqüência de erros na identificação dos sabores amargo (controles: 16,7%, AVE: 47,3%, p=0,01 e azedo (controles: 6,7%, AVE: 27,8%, p=0,05, sem diferenças para o sabores neutro (controles: 10,0%, AVE: 16,7%, p=0,50 e doce (controles: 13,3%, AVE: 16,7%, p=0,80. Os pacientes com AVE tiveram maior dificuldade para deglutir os líquidos do que os controles (pPURPOSE: to assess the perception of bitter, sour, sweet and neutral flavors in stroke patients. METHOD: we studied 36 patients with stroke (5 hemorrhagic and 31 ischemic and had a 30 subjects' control group. W performed a structural and functional oral and pharyngeal evaluation including posture, lip sealing, presence of residues, cough, choking, and cervical auscultation. Five ml of fluids with the 4 flavors ["boldus" tea (bitter, diluted lemon juice (sour, diluted sucrose (sweet, and water (neutral] were offered in random sequence under room temperature. Participants were questioned, between swallows, on the difficulty in swallowing and which flavor they had just swallowed. RESULTS: patients with stroke had greater difficulty in swallowing the fluids than control group (p<0.04. Patients made more mistakes in identifying bitter (control: 16

  14. Atividade muscular durante a marcha após acidente vascular encefálico Muscle activity during gait following stroke

    Directory of Open Access Journals (Sweden)

    Fernanda Ishida Corrêa

    2005-09-01

    Full Text Available OBJETIVO: Buscar parâmetros da marcha de pacientes após ter sofrido acidente vascular encefálico (AVE com hemiparesia. MÉTODO: Comparados 15 voluntários pós-AVE e 15 voluntários saudáveis com a mesma idade, gênero e peso. A comparação foi feita por eletromiografia utilizando cinco pares de eletrodos de superfície do lado comprometido (espástico e um eletrogoniômetro sobre o eixo articular de rotação da articulação do tornozelo em estudo. RESULTADOS: O início da atividade eletromiográfica, a partir da fase de apoio, para os músculos glúteo medial, reto femoral, tibial anterior, sóleo, e porção medial dos isquiotibiais foi significantemente ativados anteriormente durante o ciclo da marcha nos voluntários pós-AVE. O final da atividade eletromiográfica para os músculos reto femoral, tibial anterior, sóleo, e porção medial dos isquiotibiais foi significantemente prolongado nos voluntários pós-AVE. Voluntários pós-AVE demonstraram também mais co-ativação dos músculos agonistas e antagonistas da articulação do tornozelo e joelho durante a fase de balanceio. CONCLUSÃO: Essas alterações e co-contrações musculares da marcha permitem que os voluntários pós-AVE adotem um padrão de marcha mais seguro e mais estável para compensar a diminuição da informação sensorial da articulação do tornozelo.OBJECTIVE: To compare muscle activity and joint moments in the lower extremities during walking between subjects with stroke and control subjects. METHOD: We compared fifteen healthy volunteers and fifteen stroke patients, with the same age gender and weight data had been compared by electromyography. The system of signals acquisition used consisted of five pairs of electrodes of surface, beyond one electrogoniometer on the axis articulate of rotation of the joint of the ankle in study. RESULTS: Onset times with respect to heel-strike for the medial gluteus, tibialis anterior, soleus, rectus femoris and medial

  15. Análise de conceito do resultado de enfermagem Mobilidade em pacientes com acidente vascular cerebral

    Directory of Open Access Journals (Sweden)

    Rafaella Pessoa Moreira

    2014-06-01

    Full Text Available O objetivo foi realizar análise do conceito do resultado de enfermagem Mobilidade em paciente com AVC. Realizou-se revisão integrativa da literatura, por meio de acesso on-line às bases: Scopus, Pubmed, Cinahl, Cochrane e Lilacs, usando-se os descritores: mobility, stroke, nursing e sinonímias nas línguas portuguesa e espanhola. Identificaram-se 1.521 artigos de que, após seleção criteriosa, resultaram 49. Destacam-se artigos publicados no Canadá (26,7%, a partir de 2001 (95,9%, por fisioterapeutas (34,6%, em unidades de reabilitação (61,5%. Atributos identificados para Mobilidade: andar, ficar em pé, sentar, colocar a perna de um lado para outro, virar-se, iniciar e parar a locomoção, subir escadas, função motora, transferência e habilidade motora. Também foi construído caso modelo, caso contrário e identificados antecedentes: controle postural e equilíbrio; e consequentes: realiza tarefas no interior e exterior da casa e deambula sem dificuldade. Os conceitos do resultado Mobilidade encontrados nesta pesquisa precisam ser validados com especialistas na área e na prática clínica.

  16. Neurofibromatosis, stroke and basilar impression: case report Neurofibromatose, acidente vascular cerebral e impressão basilar: relato de caso

    OpenAIRE

    ELCIO JULIATO PIOVESAN; ROSANA HERMINIA SCOLA; LINEU CESAR WERNECK; Viviane H. Flumignan Zétola; EDISON MATOS NÓVAK; FABIO MASSAITI IWAMOTO; LICIANE MAIA PIOVESAN

    1999-01-01

    Neurofibromatosis type 1 (NF1) can virtually affect any organ, presenting most frequently with "cafe au lait" spots and neurofibromas. Vasculopathy is a known complication of NF1, but cerebrovascular disease is rare. We report the case of a 51-year-old man admitted to the hospital with a history of stroke four months before admission. On physical examination, he presented various "cafe au lait" spots and cutaneous neurofibromas. Neurologic examination demonstrated right-sided facial paralysis...

  17. Cerebral ischemia upregulates vascular endothelin ET(B) receptors in rat

    DEFF Research Database (Denmark)

    Stenman, Emelie; Malmsjö, Malin; Uddman, Erik;

    2002-01-01

    BACKGROUND AND PURPOSE: Elevated levels of endothelin-1 (ET-1) have been reported in cerebral ischemia. A role for ET may prove more important if the vascular receptors were changed. We addressed whether there is any change in ET receptor expression in cerebral ischemia. METHODS: The right middle...... receptors in the pathogenesis of a vascular component after cerebral ischemia....... cerebral artery (MCA) was occluded in male Wistar rats for 2 hours with the intraluminal filament method. The basilar artery and both MCAs were removed after 46 hours of recirculation. The contractile responses to ET-1, a combined ET(A) and ET(B) receptor agonist, and sarafotoxin 6c (S6c), a selective ET...

  18. Lower cranial nerve motor function in unilateral vascular lesions of the cerebral hemisphere

    OpenAIRE

    Willoughby, E W; Anderson, N.E.

    1984-01-01

    Motor function subserved by cranial nerves V, VII, X, XI, and XII was assessed in 100 patients with hemiparesis due to a unilateral vascular lesion of the cerebral hemisphere. Several of the findings were not described clearly in many of the standard textbooks of neurology. Weakness of sternomastoid when present was always contralateral to the hemiparesis. This emphasises the principle that the cerebral hemisphere controls movement of the body parts in or towards the contralateral half of the...

  19. Estimation of cerebral vascular tone during exercise; evaluation by critical closing pressure in humans

    DEFF Research Database (Denmark)

    Ogoh, Shigehiko; Brothers, R Matthew; Jeschke, Monica;

    2010-01-01

    The aim of the present study was to calculate critical closing pressure (CCP) of the cerebral vasculature at rest and during exercise to estimate cerebral vascular tone. Five men and two women were seated upright for 15 min and then performed 15 min of right-legged knee extension exercise at 40, 60...... and 75% of their maximal workload (WL(max)). Middle cerebral artery blood velocity (MCA V) and blood pressure in the radial artery were recorded. The CCP was calculated by linear extrapolation from 1 min recordings of pairs of systolic and diastolic pressure and MCA V waveforms from both the right...

  20. Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats

    DEFF Research Database (Denmark)

    Stenman, Emelie; Edvinsson, Lars

    2004-01-01

    BACKGROUND AND PURPOSE: The aim of the study was to examine how focal cerebral ischemia affects the expression and function of vascular angiotensin II receptors. MATERIALS AND METHODS: We used an intraluminal filament occlusion technique to occlude the right middle cerebral artery (MCA) of the rat...... with nonoccluded MCAs 48 hours after occlusion (Pcerebral ischemia in the rat upregulated the contractile....... These results support a role for AT1 receptors in cerebral ischemia, and we think that AT1 receptors might be a future therapeutic target in ischemic stroke....

  1. Study of the Dynamics of Transcephalic Cerebral Impedance Data during Cardio-Vascular Surgery

    Science.gov (United States)

    Atefi, S. R.; Seoane, F.; Lindecrantz, K.

    2013-04-01

    Postoperative neurological deficits are one of the risks associated with cardio vascular surgery, necessitating development of new techniques for cerebral monitoring. In this study an experimental observation regarding the dynamics of transcephalic Electrical Bioimpedance (EBI) in patients undergoing cardiac surgery with and without extracorporeal circulation (ECC) was conducted to investigate the potential use of electrical Bioimpedance for cerebral monitoring in cardio vascular surgery. Tetrapolar transcephalic EBI measurements at single frequency of 50 kHz were recorded prior to and during cardio vascular surgery. The obtained results show that the transcephalic impedance decreases in both groups of patients as operation starts, however slight differences in these two groups were also observed with the cerebral impedance reduction in patients having no ECC being less common and not as pronounced as in the ECC group. Changes in the cerebral impedance were in agreement with changes of haematocrit and temperature. The origin of EBI changes is still unexplained however these results encourage us to continue investigating the application of electrical bioimpedance cerebral monitoring clinically.

  2. Study of the Dynamics of Transcephalic Cerebral Impedance Data during Cardio-Vascular Surgery

    International Nuclear Information System (INIS)

    Postoperative neurological deficits are one of the risks associated with cardio vascular surgery, necessitating development of new techniques for cerebral monitoring. In this study an experimental observation regarding the dynamics of transcephalic Electrical Bioimpedance (EBI) in patients undergoing cardiac surgery with and without extracorporeal circulation (ECC) was conducted to investigate the potential use of electrical Bioimpedance for cerebral monitoring in cardio vascular surgery. Tetrapolar transcephalic EBI measurements at single frequency of 50 kHz were recorded prior to and during cardio vascular surgery. The obtained results show that the transcephalic impedance decreases in both groups of patients as operation starts, however slight differences in these two groups were also observed with the cerebral impedance reduction in patients having no ECC being less common and not as pronounced as in the ECC group. Changes in the cerebral impedance were in agreement with changes of haematocrit and temperature. The origin of EBI changes is still unexplained however these results encourage us to continue investigating the application of electrical bioimpedance cerebral monitoring clinically.

  3. Cerebral vascular effects of loading dose of dexmedetomidine: A Transcranial Color Doppler study

    Directory of Open Access Journals (Sweden)

    Appavoo Arulvelan

    2016-01-01

    Full Text Available Background: Dexmedetomidine has been widely used in critical care settings because of its property of maintaining stable hemodynamics and inducing conscious sedation. The use of dexmedetomidine is in increasing trend particularly in patients with neurological disorders. Very few studies have focused on the cerebral hemodynamic effects of dexmedetomidine. This study is aimed to address this issue. Methods: Thirty patients without any intracranial pathology were included in this study. Middle cerebral artery flow velocity obtained from transcranial color Doppler was used to assess the cerebral hemodynamic indices. Mean flow velocity (mFV, pulsatility index (PI, cerebral vascular resistant index (CVRi, estimated cerebral perfusion pressure (eCPP, and zero flow pressure (ZFP were calculated bilaterally at baseline and after infusion of injection Dexmedetomidine 1 mcg/Kg over 10 min. Results: Twenty-six patients completed the study protocol. After administration of loading dose of dexmedetomidine, mFV and eCPP values were significantly decreased in both hemispheres (P < 0.05; PI, CVRi, and ZFP values showed significant increase (P < 0.05 after dexmedetomidine infusion. Conclusion: Increase in PI, CVRi, and ZFP suggests that there is a possibility of an increase in distal cerebral vascular resistance (CVR with loading dose of dexmedetomidine. Decrease in mFV and eCPP along with an increase in CVR may lead to a decrease in cerebral perfusion. This effect can be exaggerated in patients with preexisting neurological illness. Further studies are needed to evaluate the effect of dexmedetomidine on various other pathological conditions involving brain like traumatic brain injury and vascular malformations.

  4. A rare combination of atypical cerebral vascular anatomy.

    Science.gov (United States)

    Koleilat, Issam; Eidt, John

    2015-10-01

    A 57-year-old woman presented with neurologic deficits consistent with a cerebrovascular accident. Her workup demonstrated the simultaneous occurrence of three uncommon cerebrovascular congenital anomalies in a single patient: (1) persistent trigeminal artery, (2) persistent fetal origin of the posterior cerebral artery and (3) bilateral occurrence of the vertebral arteries terminating in the posterior inferior cerebellar arteries. These persistent fetal cerebrovascular anatomic variants are reviewed and the clinical relevance discussed. PMID:25414171

  5. MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia

    DEFF Research Database (Denmark)

    Henriksson, Marie; Stenman, Emelie; Vikman, Petter;

    2007-01-01

    Cerebral ischaemia is associated with elevated levels of endothelin B (ETB) receptors in the ipsilateral middle cerebral artery (MCA). This up-regulation of ET receptors occurs via de novo transcription involving mitogen-activated protein kinases (MAPK). The aim of this study was to examine the e......, neurological symptoms, and ET receptor alteration. The vascular effects of U0126 provide new perspective on possible mechanisms of actions of MAPK inhibition in cerebral ischaemia.......Cerebral ischaemia is associated with elevated levels of endothelin B (ETB) receptors in the ipsilateral middle cerebral artery (MCA). This up-regulation of ET receptors occurs via de novo transcription involving mitogen-activated protein kinases (MAPK). The aim of this study was to examine...... the effect of inhibition of the MAP kinase/ERK kinase (MEK)1/2 on ET receptor alteration, brain damage, and neurology in experimental cerebral ischaemia. Transient middle cerebral artery occlusion (MCAO) was induced in male Wistar rats by the intraluminal filament technique. The animals received 100 mg...

  6. Impacto da intubação orotraqueal na deglutição do indivíduo pós-acidente vascular encefálico após cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Tatiana Magalhães de Almeida

    2015-04-01

    Full Text Available OBJETIVO:associar o grau de disfagia orofaríngea e o tempo de intubação orotraqueal no indivíduo pós-acidente vascular encefálico após cirurgia cardíaca.MÉTODOS:estudo clínico transversal descritivo, retrospectivo, realizado por meio da coleta de dados de protocolos e registros de prontuário, durante seis meses, em Hospital Público de Referência em Cardiologia. Foram analisados 25 protocolos e prontuários de indivíduos submetidos à cirurgia cardíaca, que evoluíram com acidente vascular encefálico e foram assistidos pela equipe de Fonoaudiologia. Os indivíduos foram divididos em dois grupos. O Grupo I (GI constou de 10 indivíduos com intubação orotraqueal menor que 24 horas e o Grupo II (GII de 15 indivíduos com intubação orotraqueal maior que 24 horas. Realizada avaliação clínica da deglutição e analisada a associação entre a classificação clínica do grau de comprometimento para disfagia e o tempo de intubação orotraqueal.RESULTADOS:verificou-se que no GI 40% apresentaram disfagia leve, 30% moderada e 20% grave. No GII 13,3% apresentaram disfagia leve, 33,3% moderada e 53,33% grave. Verificou-se associação linear significante entre o grau de disfagia e o tempo de IOT (p= 0,031, indicando que o número de indivíduos com disfagia moderada e grave foi maior no grupo com mais tempo de intubaçao.CONCLUSÕES:constatou-se que o tempo de intubação orotraqueal maior que 24 horas aumentou o grau da disfagia orofaríngea nesta população.

  7. Interactive effects of vascular risk burden and advanced age on cerebral blood flow

    Directory of Open Access Journals (Sweden)

    Katherine eBangen

    2014-07-01

    Full Text Available Vascular risk factors and cerebral blood flow (CBF reduction have been linked to increased risk of cognitive impairment and Alzheimer’s disease (AD; however the possible moderating effects of age and vascular risk burden on CBF in late life remain understudied. We examined the relationships among elevated vascular risk burden, age, CBF, and cognition. Seventy-one non-demented older adults completed an arterial spin labeling MR scan, neuropsychological assessment, and medical history interview. Relationships among vascular risk burden, age, and CBF were examined in a priori regions of interest (ROIs previously implicated in aging and AD. Interaction effects indicated that, among older adults with elevated vascular risk burden (i.e., multiple vascular risk factors, advancing age was significantly associated with reduced cortical CBF whereas there was no such relationship for those with low vascular risk burden (i.e., no or one vascular risk factor. This pattern was observed in cortical ROIs including medial temporal (hippocampus, parahippocampal gyrus, uncus, inferior parietal (supramarginal gyrus, inferior parietal lobule, angular gyrus, and frontal (anterior cingulate, middle frontal gyrus, medial frontal gyrus cortices. Furthermore, among those with elevated vascular risk, reduced CBF was associated with poorer cognitive performance. Such findings suggest that older adults with elevated vascular risk burden may be particularly vulnerable to cognitive change as a function of CBF reductions. Findings support the use of CBF as a potential biomarker in preclinical AD and suggest that vascular risk burden and regionally-specific CBF changes may contribute to differential age-related cognitive declines.

  8. A família também adoece!: mudanças secundárias à ocorrência de um acidente vascular encefálico na família

    Directory of Open Access Journals (Sweden)

    Eliana Sales Brito

    2008-12-01

    Full Text Available Este estudo buscou compreender o impacto da doença incapacitante na família de pacientes vítimas de acidente vascular encefálico (AVE, investigando as mudanças de ordem estrutural, social e emocional. Foram analisadas nove famílias de pacientes com primeiro episódio de AVE identificados pelo registro geral de doenças do Hospital São Rafael, Salvador, Bahia. A coleta dos dados foi realizada mediante aplicação de questionário, roteiro de entrevista, escala de avaliação funcional e observações registradas em diário de campo. O método empregado para análise dos dados foi o discurso do sujeito coletivo, produzindo representações sociais e transformando em um só discurso a fala dos sujeitos pesquisados. Constatou-se que a ocorrência de um AVE é uma experiência marcada por bruscas transformações no cotidiano familiar e na vida de cada um de seus membros. Os resultados indicam a necessidade de se habilitar a família para o cuidado ao paciente e para o autocuidado.

  9. Study on the Relationship between Plasma Homocysteine and Acute Cerebral Vascular Disease

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The levels of plasma homocysteine were determined by using high-performance liquid chromatographic method. It was found that plasma homocysteine levels were significantly higher in the patients with stroke than that in the controls. There was no correlation between plasma homocysteine levels and hypertension, smoking, concentrations of blood glucose or hypertriglyceridesemia. It was suggested that hyperhomocysteinemia may be an independent risk factor for acute cerebral vascular disease.

  10. Autonomic cerebral vascular response to sildenafil in diabetic patient

    Directory of Open Access Journals (Sweden)

    Al-Amran Fadhil G

    2012-01-01

    Full Text Available Abstract Background Erectile dysfunction is a common problem in type 2 diabetic patients who are at higher risk of cerebrovascular events, and it's recorded with sildenafil, a drug which is primarily used for erectile dysfunction. Objectives We tested the hypothesis whether or not sildenafil modulates cerebrovascular reactivity (CVR in patients with type 2 diabetes mellitus. Methods A total of 35 male participants were enrolled; eighteen with type 2 diabetes mellitus matched with seventeen normal individuals. Transcranial Doppler Ultrasonographic examination (TCD was performed for all participants to insonate the middle cerebral artery (MCA through a trans-temporal window. CVR was assessed by using breath holding (BH-hyperventilation (HV test, before and after oral 50 mg sildenafil; recordings were analyzed by using SPSS program version 12. Results In normal individuals, sildenafil did not result in statistically significant change in breath holding index (BHI from 0.91 ± 0.11 to 0.81 ± 0.09 and full range of vasodilatation (FVD from (59.4% ± 6.3% to (53.7% ± 4.9%. In diabetic patients, giving sildenafil resulted in significant increase in BHI (from 0.74 ± 0.14 to 1.03 ± 0.14 and FVD (from 60.2% ± 4.96% to 74% ± 4.8%, (p Conclusion Sildenafil significantly improves CVR in type 2 diabetic patients but not in normal subjects.

  11. Avaliação da aptidão cardiopulmonar em indivíduos com hemiparesia após acidente vascular encefálico Evaluación de la aptitud cardiopulmonar en individuos con hemiparesia tras accidente vascular encefálico Evaluation of cardiopulmonary fitness in individuals with hemiparesis after cerebrovascular accident

    OpenAIRE

    Angélica Cristiane Ovando; Stella Maris Michaelsen; Tales de Carvalho; Vanessa Herber

    2011-01-01

    FUNDAMENTO: Devido à hemiparesia, a avaliação da aptidão cardiorrespiratória de indivíduos após acidente vascular encefálico (AVE), por meio de testes ergométricos com protocolos convencionais, tem se tornado um desafio. OBJETIVO: Realizar teste cardiopulmonar (TCP) em hemiparéticos para uma avaliação pré-participação visando uma criteriosa prescrição de exercício aeróbico. MÉTODOS: Participaram do estudo 8 indivíduos com hemiparesia crônica, que foram submetidos a TCP realizado com protocolo...

  12. Cerebral blood flow single-photon emission tomography with 123I-IMP in vascular dementia

    International Nuclear Information System (INIS)

    Cerebral blood flow differences between patients with vascular dementia, patients with multiple lacunar infarction without cognitive dysfunction, and age-matched controls were examined. Thirty four patients with vascular dementia (VD) were selected from consecutive referrals to the Memory Clinic at Narita Memorial Hospital. All the patients had routine assessment including history, physical and neurological examinations, neuropsychological assessment, blood tests, EEG, head MRI, and single photon emission computed tomography (SPECT). All of them fulfilled the NINDS-AIREN diagnostic criteria for vascular dementia. Thirty nine patients with multiple lacunar infarction without cognitive dysfunction and 110 age-matched controls were included in this study. Mean cerebral blood flow (mCBF) and regional cerebral blood flow (rCBF) were measured using N-isopropyl-P-123I-iodoamphetamine (123I-IMP) and SPECT imager. The mCBF in VD was 27.6±5.3 ml/100 g/min, while those in the control group and multiple lacunar infarction without cognitive dysfunction were 36.6±6.1 ml/100 g/min and 32.5±5.5 ml/100 g/min, respectively. The patients with VD demonstrated significantly reduced mCBF and rCBF in twenty regions including both cerebellar hemispheres as compared with those of the control group. Although there was no significant rCBF differences in bilateral inferior occipital regions and the right cerebellar hemisphere between patients with VD and multiple lacunar infarction without cognitive dysfunction, we could find significant lower rCBF in the remaining brain areas. In spite of the severity of VD, the diffuse decrease of cerebral blood flow was recognized in all patients with VD. (author)

  13. Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment.

    Science.gov (United States)

    Banerjee, Gargi; Wilson, Duncan; Jäger, Hans R; Werring, David J

    2016-05-01

    Dementia is a global growing concern, affecting over 35 million people with a global economic impact of over $604 billion US. With an ageing population the number of people affected is expected double over the next two decades. Vascular cognitive impairment can be caused by various types of cerebrovascular disease, including cortical and subcortical infarcts, and the more diffuse white matter injury due to cerebral small vessel disease. Although this type of cognitive impairment is usually considered the second most common form of dementia after Alzheimer's disease, there is increasing recognition of the vascular contribution to neurodegeneration, with both pathologies frequently coexisting. The aim of this review is to highlight the recent advances in the understanding of vascular cognitive impairment, with a focus on small vessel diseases of the brain. We discuss recently identified small vessel imaging markers that have been associated with cognitive impairment, namely cerebral microbleeds, enlarged perivascular spaces, cortical superficial siderosis, and microinfarcts. We will also consider quantitative techniques including diffusion tensor imaging, magnetic resonance perfusion imaging with arterial spin labelling, functional magnetic resonance imaging and positron emission tomography. As well as potentially shedding light on the mechanism by which cerebral small vessel diseases cause dementia, these novel imaging biomarkers are also of increasing relevance given their ability to guide diagnosis and reflect disease progression, which may in the future be useful for therapeutic interventions. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. PMID:26687324

  14. Effects of ginsenosides on vascular reactivity in rat cerebral and renal arteries

    Institute of Scientific and Technical Information of China (English)

    WONG Wing-tak; LEUNG Fung-ping; YUNG Lai-hang; TIAN Xiao-yu; WONG Ricky Ngok Shun; HUANG Yu

    2008-01-01

    Objective To investigate possible mechanisms underlying the antioxidant property (1) and the in vitro vasodilator effects (2) of the two ginsenosides, Rb1 and Rg1, in isolated rat renal and cerebral arteries. Methods Arterial rings were mounted in a multi-channel myograph for recording of isometric tension. To examine the antioxidant activity, some rings were exposed to a free radical-generating reaction (hypoxan-thine and xanthine oxidase) with and without pre-treatment with ginsenosides. The calcium antagonistic effects were tested on rings contracted by membrane depolarization in elevated extracellular potassium ions, a condition that promoted Ca2+ influx in vascular smooth muscle cells. Results Ginsenosides protected endothelial function (endothelial nitric oxide-dependent relaxation) against oxidative stress; (2) ginsenoside Rb1 reduced the high K+ -induced contractions of both renal and cerebral arteries while ginsenoside Rgl relaxed the rat cerebral artery but not the renal artery. Conclusions Ginsenosides are vaso-protective via (1) the antioxidant activity which protects endothelial cell function and (2) the inhibition of Ca2+ influx through voltage-sensitive Ca2+ channels in vascular smooth muscle. The vasodilator effects may suggest the potential preventive or therapeutic values of ginsenosides against stroke and renal hypertension.

  15. Regional cerebral blood flow in vascular depression assessed by 123I-IMP SPECT

    International Nuclear Information System (INIS)

    As the prevalence of white matter hyperintensities detected on T2 weighted MRI scans in patients with late-onset depression is higher than that in nondepressed patients, the concept of ''vascular depression'' (VDep) was introduced in 1997. However, the pathology of vascular depression has not been clarified. This study examined the differences in functional imaging between vascular and non-vascular depression (non-VDep). We utilized 123I-IMP single photon emission computed tomography (SPECT) to compare regional cerebral blood flows (rCBF) between 9 patients with VDep (Krishnan criteria) and 11 age- and sex-matched patients with non-VDep in both depressed and remitted states. In both VDep and non-VDep patients, mean rCBF increased significantly as depression improved, partially aided by changes in left anterior temporal blood flow. In addition, compared to non-VDep patients, the left anterior frontal rCBF for VDep patients was significantly lower in both depressed and remitted states. Left anterior temporal rCBF therefore appears to represent a state marker that increases as symptoms associated with late-onset depression improve, regardless of vascular changes. Furthermore, in VDep patients, left anterior frontal rCBF was low in both states compared to non-VDep patients, and might not only represent a trait marker, but also correlated with the duration of disease and likelihood of recurrence and relapse. (author)

  16. Effects of cerebrolysin on moderate cognitive impairments in cerebral vascular insufficiency (a clinical-electrophysiological study).

    Science.gov (United States)

    Damulin, I V; Koberskaya, N N; Mkhitaryan, E A

    2008-07-01

    The efficacy of treatment with cerebrolysin was studied in 40 patients with cerebral vascular insufficiency. Cerebrolysin (20 daily i.v. infusions of 10 ml in 200 ml of physiological saline) was found to be an effective means of treating this group of patients. Courses of cerebrolysin treatment decreased the severity of memory and attention impairments, improving the overall cognitive status of the patients. Clinical observations and neuropsychological testing were supported by electrophysiological results, in terms of the P300 cognitive evoked potential. The effects of treatment at the doses used here were delayed and were seen three months after completion of treatment.

  17. Effect of preceding exercise on cerebral and splanchnic vascular responses to mental task

    Directory of Open Access Journals (Sweden)

    Someya Nami

    2012-06-01

    Full Text Available Abstract Background To investigate the effect of preceding acute exercise on the peripheral vascular response to a mental task, we measured splanchnic and cerebral blood flow responses to performing a mental task after exercise and resting. Methods In the exercise trial, 11 males exercised for 30 min on a cycle ergometer with a workload set at 70% of the age-predicted maximal heart rate for each individual. After a 15-min recovery period, the subjects rested for 5 min for pre-task baseline measurement and then performed mental arithmetic for 5 min followed by 5 min of post-task measurement. In the resting trial, they rested for 45 min and pre-task baseline data was obtained for 5 min. Then mental arithmetic was performed for 5 min followed by post-task measurement. We measured the mean blood velocity in the middle cerebral artery and superior mesenteric artery and the mean arterial pressure. Results Mean arterial pressure and mean blood velocity in the middle cerebral artery were significantly higher than the baseline during mental arithmetic in both exercise and resting trials. Mean blood velocity in the middle cerebral artery during mental arithmetic was greater in the control trial than the exercise trial. Mean blood velocity in the superior mesenteric artery showed no significant change during mental arithmetic from baseline in both trials. Conclusion These results suggest that acute exercise can moderate the increase in cerebral blood flow induced by a mental task.

  18. Stabiliztin of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 is Critical for Vascular Development

    Energy Technology Data Exchange (ETDEWEB)

    Y He; H Zhang; L Yu; M Gunel; T Boggon; H Chen; W Min

    2011-12-31

    Cerebral cavernous malformations (CCMs) are human vascular malformations caused by mutations in three genes of unknown function: CCM1, CCM2, and CCM3. CCM3, also known as PDCD10 (programmed cell death 10), was initially identified as a messenger RNA whose abundance was induced by apoptotic stimuli in vitro. However, the in vivo function of CCM3 has not been determined. Here, we describe mice with a deletion of the CCM3 gene either ubiquitously or specifically in the vascular endothelium, smooth muscle cells, or neurons. Mice with global or endothelial cell-specific deletion of CCM3 exhibited defects in embryonic angiogenesis and died at an early embryonic stage. CCM3 deletion reduced vascular endothelial growth factor receptor 2 (VEGFR2) signaling in embryos and endothelial cells. In response to VEGF stimulation, CCM3 was recruited to and stabilized VEGFR2, and the carboxyl-terminal domain of CCM3 was required for the stabilization of VEGFR2. Indeed, the CCM3 mutants found in human patients lacking the carboxyl-terminal domain were labile and were unable to stabilize and activate VEGFR2. These results demonstrate that CCM3 promotes VEGFR2 signaling during vascular development.

  19. Efeitos da facilitação neuromuscular proprioceptiva na estabilidade postural e risco de quedas em pacientes com sequela de acidente vascular encefálico: estudo piloto Efectos de la facilitación neuromuscular propioceptiva en la estabilidad postural y riesgo de caídas en pacientes con secuela de accidente vascular encefálico: estudio piloto Effects of proprioceptive neuromuscular facilitation in postural stability and risk of falls in patients with sequelae of stroke: pilot study

    OpenAIRE

    Natália Noman de Lacerda; Érika Baptista Gomes; Hudson Azevedo Pinheiro

    2013-01-01

    O controle do tronco é uma habilidade motora básica necessária para executar diversas tarefas funcionais, e é deficiente em pacientes que sofreram acidente vascular encefálico (AVE). Objetivo: Avaliar o efeito do método facilitação neuromuscular proprioceptiva (PNF) na estabilidade postural e risco de quedas em pacientes com sequela de AVE. Metodologia: Foi realizado estudo de intervenção que consistiu em treinamento da estabilidade postural por meio de um protocolo fixo constituído por 5 exe...

  20. Hemorrhagic stroke after naphazoline exposition: case report Acidente vascular encefálico hemorrágico após exposição à nafazolina: relato de caso

    Directory of Open Access Journals (Sweden)

    Jorge A.A. Zavala

    2004-09-01

    Full Text Available Ten percent of all strokes are due to spontaneous cerebral hemorrhages. They are associated to drugs (licit and illicit in 9.5% of all cases in young adults. This is a case report of a 44-year-old man, without previous morbidities, who presented a sudden onset headache and arterial hypertension 24 hours after use of naphazoline as nasal decongestant. Cranial tomography showed right thalamus hemorrhage. Cerebral angiography showed no aneurisms, vascular malformations or vasculitis. No other risk factors were found during investigation in this patient and the stroke was attributed to naphazoline exposition.Dez por cento de todos os eventos vasculares encefálicos são devido às hemorragias intracerebrais espontâneas, associados a drogas (lícitas e ilícitas em 9,5% de todos os casos em adultos jovens. Relatamos o caso de um homem de 44 anos de idade, sem doenças prévias, que apresentou cefaléia súbita e hipertensão arterial 24 horas após o uso de congestionante nasal contendo nafazolina. A tomografia de crânio evidenciou hemorragia talâmica. Durante a investigação não foram encontrados outros fatores de risco e a hemorragia foi atribuída à exposição à nafazolina.

  1. Decreased expression of transient receptor potential channels in cerebral vascular tissue from patients after hypertensive intracerebral hemorrhage

    DEFF Research Database (Denmark)

    Thilo, Florian; Suess, Olaf; Liu, Ying;

    2011-01-01

    the expression of TRP expression and hypoxic conditions caused by the intracerebral bleeding, we examined the expression of hypoxia inducible factor 1a (HIF1a). Transcripts of TRPC3, TRPC5, TRPM6, and HIF1a were significantly reduced in cerebral vascular tissue from patients after hypertensive intracerebral...... hemorrhage compared to controls. TRPC3 mRNA correlated well with the expression of HIF1a mRNA (r(2) = 0.59; p = 0.01). TRPC3 expression is associated with hypertension and hypoxic conditions in human cerebral vascular tissue....

  2. Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein.

    NARCIS (Netherlands)

    Miao, J.; Xu, F.; Davis, J.; Otte-Holler, I.; Verbeek, M.M.; Nostrand, W.E. van

    2005-01-01

    Cerebral vascular amyloid beta-protein (Abeta) deposition, also known as cerebral amyloid angiopathy, is a common pathological feature of Alzheimer's disease. Additionally, several familial forms of cerebral amyloid angiopathy exist including the Dutch (E22Q) and Iowa (D23N) mutations of Abeta. Incr

  3. Regional cerebral blood flow analysis of vascular dementia by the single photon emission computed tomography

    International Nuclear Information System (INIS)

    In order to evaluate the relationship between the regional cerebral blood flow (CBF) and cerebrovascular dementia, eleven patients with vascular dementia and eight patients with non-demented infarction were studied and regional CBF were measured quantitatively with single photon emission computed tomography (SPECT) by using N-isopropyl-p-(I-123) iodoamphetamine. All cases were basal infarction and vascular dementia were diagnosed by less than 21.5 of the Hasegawa's dementia score and more than 7 of Hachinsk's ischemic score. The results of the present study were as follows: (1) Cerebrovascular dementia showed lower mean CBF value compared with non-demented group. (2) Regional CBF of bilateral frontal areas and affected basal ganglia were significantly reduced than occipital area in the dementia group. (3) A comparison of regional CBF and the Hasegawa's dementia score revealed a statistically significant correlation at the bilateral frontal areas in the dementia group. It is possible that measuring the regional CBF quantitatively by IMP-SPECT is useful for clinical analysis of vascular dementia. (author)

  4. ESTUDOS SOBRE ABORDAGENS TERAPÊUTICAS PARA O ACIDENTE VASCULAR ENCEFÁLICO (AVE EM MODELO ANIMAL: USO DE CÉLULAS DERIVADAS DE MEDULA ÓSSEA E DE FLAVONOIDES

    Directory of Open Access Journals (Sweden)

    Arthur Giraldi-Guimarães

    2012-01-01

    Full Text Available O Acidente Vascular Encefálico é a maior causa de incapacitação em seres humanos adultos, representandoatualmente um grande custo pessoal e social. Empregando modelos experimentais de lesões cerebrais focais,este projeto tem como objetivo geral avaliar o efeito benéfico de abordagens terapêuticas promissoras notratamento do AVE e de outras lesões cerebrais. Em estudos concluídos, tivemos como objetivo principalavaliar a capacidade de indução de recuperação funcional em testes sensorimotores pelas terapias comcélulas derivadas de medula óssea e com o flavonoide rutina. Foram utilizados o modelo de isquemia corticalfocal unilateral por termocoagulação dos vasos cortical superficiais, e o modelo da ablação cortical focalunilateral por sucção, ambos causando lesão de mesma localização e extensão. Nossos resultados mostraramque as células mononucleares de medula óssea (MNMOs e as células-tronco mesenquimais (CTMs foramcapazes de promover recuperação de função sensorimotora em testes de movimentos menos sofisticados, em21ambos os modelos de lesão. Entretanto, as MNMOs não promoveram aumento da recuperação demovimentos de destreza, que envolvem treinamento, como agarrar uma pílula de ração. No estudo com oflavonoide rutina, demonstramos que houve promoção de recuperação sensorimotora após a isquemia, e estase correlacionou com uma ação neuroprotetora do flavonoide. Nossos resultados sugerem que tanto asMNMOs e como a rutina podem ser utilizados como terapias eficazes para o tratamento de lesões cerebrais,quando administradas na fase aguda da doença. Os estudos precisam ser aprofundados no sentido de ampliaros conhecimentos sobre os seus respectivos mecanismos celulares e moleculares de ação.

  5. Controle autonômico do coração e fração de ejeção na fase crônica do acidente vascular encefálico

    Directory of Open Access Journals (Sweden)

    Suenimeire Vieira

    2014-12-01

    Full Text Available Introdução: Sujeitos acometidos por acidente vascular encefálico (AVE podem apresentar alterações na estrutura e função do coração e na modulação autonômica. Objetivo: Verificar função autonômica e cardíaca sistólica em homens após AVE, e se estas variáveis estão associadas. Métodos: Foram avaliados oito homens, com idade entre 55 e 65 anos, acometidos por lesão cerebrovascular há pelo menos seis meses e todos com hemiparesia. Foram realizadas as seguintes avaliações: 1 Ecocardiografia, para avaliar a função cardíaca sistólica. 2 Registro da frequência cardíaca (FC e dos intervalos R-R (IRR, batimento a batimento, para avaliação do controle neural do coração. Esses dados foram analisados no domínio da frequência, por meio das análises dos seguintes componentes espectrais: alta frequência; baixa frequência e a razão BF/AF. Foi aplicado o teste de correlação de Pearson (p ≤ 0,05. Resultados: Características demográficas, antropométricas e fisiológicas: Idade = 58,62 ± 2,88 anos; IMC = 27,41 ± 5,33 kg/m2 ; BF = 61,78 ± 26,79 (un; AF = 38,23 ± 26,79 (un; BF/AF = 3,41 ± 3,38; FE = 0,65 ± 0,04. Não houve correlação estatisticamente significativa entre os índices espectrais BF e AF com fração de ejeção e a presença de fatores de risco para AVE. Conclusão: No presente estudo, a fração de ejeção do ventrículo esquerdo encontra-se normal e o controle neural do coração pode estar normal ou não, mesmo na presença de fatores de risco para o AVE.

  6. Alterações eletromiográficas dos músculos do tronco de pacientes com hemiparesia após acidente vascular encefálico Electromyographic alterations of trunk muscle of patients with post-stroke hemiparesis

    Directory of Open Access Journals (Sweden)

    Fernando Cesar Iwamoto Marcucci

    2007-09-01

    Full Text Available O acidente vascular encefálico é a principal causa de incapacidade crônica em adultos, porém poucos estudos avaliaram a motricidade do tronco nestes indivíduos. OBJETIVO: Comparar a atividade mioelétrica do tronco entre indivíduos hemiparéticos e controle. MÉTODO: Foram avaliados oito indivíduos hemiparéticos e oito controles, por meio de eletromiografia de superfície (EMGs, durante atividades de flexão dos membros inferiores e rotação do tronco em supino; levantar e elevação dos membros superiores na posição sentada. RESULTADOS: O músculo reto abdominal parético apresentou maior ativação que o grupo controle (p=0,031 durante a flexão dos membros inferiores. Os músculos oblíquos apresentaram, bilateralmente, maior ativação na elevação dos membros inferiores do que na rotação (p=0,014 e p=0,002, respectivamente. Não houve diferenças entre músculos eretores durante as atividades. CONCLUSÃO: Os músculos flexores do tronco de indivíduos hemiparéticos apresentaram alterações motoras no reto abdominal do lado parético e realizam compensações por meio dos oblíquos externos.Stroke is the main cause of chronic disability in adults, but few studies evaluated the trunk motor activity in affected subjects. OBJECTIVE: To compare the myoelectrical activity of trunk muscle in hemiparetic and control subjects. METHOD: Eight hemiparetic and eight control subjects were assessed during lower extremities flexion and trunk rotation in supine position; stand up and rise up upper extremities in seated position. RESULTS: Paretic rectus abdominis presented a higher activation than control group (p=0.031 during lower extremities elevation. Obliquus externus abdominis showed a bilateral higher activation during lower extremities elevation than rotation activities (p=0.014 and p=0.002, respectively. There was no difference in extension activities comparison. CONCLUSION: Trunk flexor muscles of hemiparetic subjects demonstrated

  7. Atuação da enfermagem no autocuidado e reabilitação de pacientes que sofreram Acidente Vascular Encefálico Actuación de la enfermería en el autocuidado y rehabilitación de pacientes que sufreran Accidente Nursing activities in self-care and rehabilitation of patients who suffered Stroke

    OpenAIRE

    Juliana Cristina Lessmann; Fernanda De Conto; Greice Ramos; Míriam Susskind Borenstein; Betina Homer Schlindwein Meirelles

    2011-01-01

    Quando o cérebro sofre alterações vasculares podem ocorrer sérias sequelas motoras, sensoriais e na percepção. Nesta perspectiva o estudo objetiva relatar/ compartilhar assistência de Enfermagem ao indivíduo acometido pelo Acidente Vascular Encefálico enfatizando a reabilitação e o autocuidado baseado em Orem. Trata-se de relato de experiência de prática assistencial, realizada de maio a julho de 2006, com 15 indivíduos e seus familiares, em um centro de reabilitação da região sul do Brasil. ...

  8. Multichannel optical brain imaging to separate cerebral vascular, tissue metabolic, and neuronal effects of cocaine

    Science.gov (United States)

    Ren, Hugang; Luo, Zhongchi; Yuan, Zhijia; Pan, Yingtian; Du, Congwu

    2012-02-01

    Characterization of cerebral hemodynamic and oxygenation metabolic changes, as well neuronal function is of great importance to study of brain functions and the relevant brain disorders such as drug addiction. Compared with other neuroimaging modalities, optical imaging techniques have the potential for high spatiotemporal resolution and dissection of the changes in cerebral blood flow (CBF), blood volume (CBV), and hemoglobing oxygenation and intracellular Ca ([Ca2+]i), which serves as markers of vascular function, tissue metabolism and neuronal activity, respectively. Recently, we developed a multiwavelength imaging system and integrated it into a surgical microscope. Three LEDs of λ1=530nm, λ2=570nm and λ3=630nm were used for exciting [Ca2+]i fluorescence labeled by Rhod2 (AM) and sensitizing total hemoglobin (i.e., CBV), and deoxygenated-hemoglobin, whereas one LD of λ1=830nm was used for laser speckle imaging to form a CBF mapping of the brain. These light sources were time-sharing for illumination on the brain and synchronized with the exposure of CCD camera for multichannel images of the brain. Our animal studies indicated that this optical approach enabled simultaneous mapping of cocaine-induced changes in CBF, CBV and oxygenated- and deoxygenated hemoglobin as well as [Ca2+]i in the cortical brain. Its high spatiotemporal resolution (30μm, 10Hz) and large field of view (4x5 mm2) are advanced as a neuroimaging tool for brain functional study.

  9. Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Oriana S. [Yale Univ., New Haven, CT (United States); Deng, Hanqiang [Shanghai Jiao Tong Univ. School of Medicine (SJTU-SM), Shanghai (China); Liu, Dou [Yale Univ. School of Medicine, New Haven, CT (United States); Zhang, Ya [Yale Univ. School of Medicine, New Haven, CT (United States); Wei, Rong [Shanghai Jiao Tong Univ. School of Medicine (SJTU-SM), Shanghai (China); Deng, Yong [Yale Univ. School of Medicine, New Haven, CT (United States); Zhang, Fan [Yale Univ. School of Medicine, New Haven, CT (United States); Louvi, Angeliki [Yale Univ. School of Medicine, New Haven, CT (United States); Turk, Benjamin E. [Yale Univ., New Haven, CT (United States); Boggon, Titus J. [Yale Univ., New Haven, CT (United States); Su, Bing [Shanghai Jiao Tong Univ. School of Medicine (SJTU-SM), Shanghai (China)

    2015-08-03

    Cerebral cavernous malformations 2 (CCM2) loss is associated with the familial form of CCM disease. The protein kinase MEKK3 (MAP3K3) is essential for embryonic angiogenesis in mice and interacts physically with CCM2, but how this interaction is mediated and its relevance to cerebral vasculature are unknown. Here we report that Mekk3 plays an intrinsic role in embryonic vascular development. Inducible endothelial Mekk3 knockout in neonatal mice is lethal due to multiple intracranial haemorrhages and brain blood vessels leakage. We discover direct interaction between CCM2 harmonin homology domain (HHD) and the N terminus of MEKK3, and determine a 2.35 Å cocrystal structure. We find Mekk3 deficiency impairs neurovascular integrity, which is partially dependent on Rho–ROCK signalling, and that disruption of MEKK3:CCM2 interaction leads to similar neurovascular leakage. We conclude that CCM2:MEKK3-mediated regulation of Rho signalling is required for maintenance of neurovascular integrity, unravelling a mechanism by which CCM2 loss leads to disease.

  10. Systemic and cerebral vascular endothelial growth factor levels increase in murine cerebral malaria along with increased Calpain and caspase activity and can be reduced by erythropoietin treatment

    DEFF Research Database (Denmark)

    Hempel, Casper; Hoyer, Nils; Kildemoes, Anna;

    2014-01-01

    The pathogenesis of cerebral malaria (CM) includes compromised microvascular perfusion, increased inflammation, cytoadhesion, and endothelial activation. These events cause blood-brain barrier disruption and neuropathology and associations with the vascular endothelial growth factor (VEGF...... increased levels of VEGF in brain and plasma and decreased plasma levels of soluble VEGF receptor 2. EPO treatment normalized VEGF receptor 2 levels and reduced brain VEGF levels. Hypoxia-inducible factor (HIF)-1α was significantly upregulated whereas cerebral HIF-2α and EPO levels remained unchanged....... Furthermore, we noticed increased caspase-3 and calpain activity in terminally ill mice, as measured by protease-specific cleavage of α-spectrin and p35. In conclusion, we detected increased cerebral and systemic VEGF as well as HIF-1α, which in the brain were reduced to normal in EPO-treated mice. Also...

  11. Vascular inward rectifier K+ channels as external K+ sensors in the control of cerebral blood flow.

    Science.gov (United States)

    Longden, Thomas A; Nelson, Mark T

    2015-04-01

    For decades it has been known that external K(+) ions are rapid and potent vasodilators that increase CBF. Recent studies have implicated the local release of K(+) from astrocytic endfeet-which encase the entirety of the parenchymal vasculature-in the dynamic regulation of local CBF during NVC. It has been proposed that the activation of KIR channels in the vascular wall by external K(+) is a central component of these hyperemic responses; however, a number of significant gaps in our knowledge remain. Here, we explore the concept that vascular KIR channels are the major extracellular K(+) sensors in the control of CBF. We propose that K(+) is an ideal mediator of NVC, and discuss KIR channels as effectors that produce rapid hyperpolarization and robust vasodilation of cerebral arterioles. We provide evidence that KIR channels, of the KIR 2 subtype in particular, are present in both the endothelial and SM cells of parenchymal arterioles and propose that this dual positioning of KIR 2 channels increases the robustness of the vasodilation to external K(+), enables the endothelium to be actively engaged in NVC, and permits electrical signaling through the endothelial syncytium to promote upstream vasodilation to modulate CBF.

  12. Infarctions in the vascular territory of the posterior cerebral artery: clinical features in 232 patients

    Directory of Open Access Journals (Sweden)

    Parra Olga

    2011-09-01

    Full Text Available Abstract Background Ischemic stroke caused by infarction in the territory of the posterior cerebral artery (PCA has not been studied as extensively as infarctions in other vascular territories. This single centre, retrospective clinical study was conducted a to describe salient characteristics of stroke patients with PCA infarction, b to compare data of these patients with those with ischaemic stroke due to middle cerebral artery (MCA and anterior cerebral artery (ACA infarctions, and c to identify predictors of PCA stroke. Findings A total of 232 patients with PCA stroke were included in the "Sagrat Cor Hospital of Barcelona Stroke Registry" during a period of 19 years (1986-2004. Data from stroke patients are entered in the stroke registry following a standardized protocol with 161 items regarding demographics, risk factors, clinical features, laboratory and neuroimaging data, complications and outcome. The characteristics of these 232 patients with PCA stroke were compared with those of the 1355 patients with MCA infarctions and 51 patients with ACA infarctions included in the registry. Infarctions of the PCA accounted for 6.8% of all cases of stroke (n = 3808 and 9.6% of cerebral infarctions (n = 2704. Lacunar infarction was the most frequent stroke subtype (34.5% followed by atherothrombotic infarction (29.3% and cardioembolic infarction (21.6%. In-hospital mortality was 3.9% (n = 9. Forty-five patients (19.4% were symptom-free at hospital discharge. Hemianopia (odds ratio [OR] = 6.43, lacunar stroke subtype (OR = 2.18, symptom-free at discharge (OR = 1.92, limb weakness (OR = 0.10, speech disorders (OR = 0.33 and cardioembolism (OR = 0.65 were independent variables of PCA stroke in comparison with MCA infarction, whereas sensory deficit (OR = 2.36, limb weakness (OR = 0.11 and cardioembolism as stroke mechanism (OR = 0.43 were independent variables associated with PCA stroke in comparison with ACA infarction. Conclusions Lacunar stroke is

  13. Vascular endothelial growth factor induced angiogenesis following focal cerebral ischemia/reperfusion injury in rabbits

    Institute of Scientific and Technical Information of China (English)

    Huaijun Liu; Jiping Yang; Fenghai Liu; Qiang Zhang; Hui Li

    2006-01-01

    BACKGROUND: Therapeutic angiogenesis has opened up new pathway for the treatment of ischemic cerebrovascular disease in recent years. The exploration of the effect of vascular endothelial growth factor (VEGF) on inducing angiogenesis following ischemia/reperfusion injury can provide better help for the long-term treatment of cerebrovascular disease in clinic.OBJECTIVE: To observe the effect of VEGF on inducing angiogenesis following focal cerebral ischemia/reperfusion injury in rabbits through the angiogenesis of microvessels reflected by the expression of the factors of vascular pseudohemophilia.DESIGN: A randomized controlled animal trial.SETTING: Department of Medical Imaging, Second Hospital of Hebei Medical University.MATERIALS: Sixty-five healthy male New Zealand rabbits of clean degree, weighing (2.6±0.2) kg, aged4.5-5 months, were used. The polyclonal antibody against vascular pseudohemophilia (Beijing Zhongshan Company), recombinant VEGF165 (Peprotech Company, USA), biotinylated second antibody and ABC compound (Wuhan Boster Company) were applied.METHODS: The experiments were carried out in the Laboratory of Neuromolecular Imaging and Neuropathy,Second Hospital of Hebei Medical University from May to August in 2005. ① The rabbits were randomly divided into three groups: sham-operated group (n=15), control group (n=25) and VEGF-treated group(n=25). In the control group and VEGF-treated group, models were established by middle cerebral artery occlusion (MCAO) induced focal cerebral ischemia/reperfusion. In the VEGF-treated group, VEGF165(2.5 mg/L) was stereotactically injected into the surrounding regions of the infarcted sites immediately after the 2-hour ischemia/reperfusion; Saline of the same dosage was injected in the control group. But the rabobserved on the 3rd, 7th, 14th, 28th and 70th days of the experiment respectively, 3 rabbits in the sham-operated group and 5 in the control group and VEGF-treated group were observed at each time point. The

  14. Optical measures of changes in cerebral vascular tone during voluntary breath holding and a Sternberg memory task.

    Science.gov (United States)

    Tan, Chin Hong; Low, Kathy A; Schneider-Garces, Nils; Zimmerman, Benjamin; Fletcher, Mark A; Maclin, Edward L; Chiarelli, Antonio M; Gratton, Gabriele; Fabiani, Monica

    2016-07-01

    The human cerebral vasculature responds to changes in blood pressure and demands for oxygenation via cerebral autoregulation. Changes in cerebrovascular tone (vasoconstriction and vasodilation) also mediate the changes in blood flow measured by the BOLD fMRI signal. This cerebrovascular reactivity is known to vary with age. In two experiments, we demonstrate that cerebral pulse parameters measured using optical imaging can quantify changes in cerebral vascular tone, both globally and locally. In experiment 1, 51 older adults (age range=55-87) performed a voluntary breath-holding task while cerebral pulse amplitude measures were taken. We found significant pulse amplitude variations across breath-holding periods, indicating vasodilation during, and vasoconstriction after breath holding. The breath-holding index (BHI), a measure of cerebrovascular reactivity (CVR) was derived and found to correlate with age. BHI was also correlated with performance in the Modified Mini-Mental Status Examination, even after controlling for age and education. In experiment 2, the same participants performed a Sternberg task, and changes in regional pulse amplitude between high (set-size 6) and low (set-size 2) task loads were compared. Only task-related areas in the fronto-parietal network (FPN) showed significant reduction in pulse amplitude, indicating vasodilation. Non-task-related areas such as the somatosensory and auditory cortices did not show such reductions. Taken together, these experiments suggest that optical pulse parameters can index changes in brain vascular tone both globally and locally, using both physiological and cognitive load manipulations.

  15. O PRODUTO COMO CAUSADOR DE ACIDENTES

    Directory of Open Access Journals (Sweden)

    Widomar Carpes Jr

    2004-06-01

    Full Text Available Neste artigo analisa-se a contribuição dos produtos para a geração de acidentes, apresentando-se estatísticas de acidentes de trabalho, de trânsito e aeronáuticos. Além disso, para melhor ilustrar a relação entre produtos e a ocorrência de acidentes, alguns casos de acidentes ocorridos e divulgados pela mídia são comentados. As estatísticas e os casos comentados demonstram a importância do estudo dos acidentes envolvendo produtos, evidenciando que praticamente todos os acidentes estão relacionados com o uso de produtos industrializados. Então, se analisa histórica e criticamente as principais teorias de acidentes de trabalho, porque são as únicas teorias existentes em relação aos acidentes. Além delas, são analisados os diversos conceitos sobre o erro humano e sua ocorrência, pois estes são apontados como grandes causadores de acidentes. Nesta análise, se observa que os acidentes estão mais relacionados aos perigos ou às características perigosas dos produtos do que às atitudes e ao comportamento do usuário. Faz-se uma revisão dos conceitos associados aos acidentes, tais como perigo, risco, acidente e dano, a partir dos quais apresenta-se um fluxograma contendo os elementos necessários para a manifestação dos acidentes. Ao final, conclui-se que a participação dos produtos na ocorrência de acidentes é evidente e que o comportamento do usuário é dependente das características do produto e da situação na qual ele é utilizado.

  16. Systemic and cerebral vascular endothelial growth factor levels increase in murine cerebral malaria along with increased calpain and caspase activity and can be reduced by erythropoietin treatment

    Directory of Open Access Journals (Sweden)

    Casper eHempel

    2014-06-01

    Full Text Available The pathogenesis of cerebral malaria includes compromised microvascular perfusion, increased inflammation, cytoadhesion and endothelial activation. These events cause blood-brain barrier disruption and neuropathology and can be associated with the vascular endothelial growth factor (VEGF signalling pathway. We studied this pathway in mice infected with Plasmodium berghei ANKA causing murine cerebral malaria with or without the use of erythropoietin as adjunct therapy. ELISA and western blotting was used for quantification of VEGF and relevant proteins in brain and plasma. Cerebral malaria increased levels of VEGF in brain and plasma and decreased plasma levels of soluble VEGF receptor 2. Erythropoietin treatment normalised VEGF receptor 2 levels and reduced brain VEGF levels. Hypoxia-inducible factor (HIF-1α was significantly upregulated whereas cerebral HIF-2α and erythropoietin levels remained unchanged. Furthermore, we noticed increased caspase-3 and calpain activity in terminally ill mice, as measured by protease-specific cleavage of α-spectrin and p35. In conclusion, we detected increased cerebral and systemic VEGF as well as HIF-1α, which in the brain were reduced to normal in erythropoietin-treated mice. Also caspase and calpain activity was reduced markedly in erythropoietin-treated mice.

  17. Confiabilidade do Perfil de Saúde de Nottingham após acidente vascular encefálico Reliability of the Nottingham Health Profile after suffering a stroke

    Directory of Open Access Journals (Sweden)

    Dinalva Lacerda Cabral

    2012-05-01

    Full Text Available O artigo tem o objetivo de avaliar a confiabilidade, a consistência interna e a concordância do instrumento de qualidade de vida (QV Perfil de Saúde de Nottingham (PSN em indivíduos após Acidente Vascular Encefálico (AVE. Estudo do tipo transversal realizado em comunidades da Cidade do Recife-PE. A amostra foi composta por 53 indivíduos na fase crônica do AVE. Após verificação do estado cognitivo foi aplicado o PSN. Utilizou-se estatística descritiva para caracterizar a amostra; a consistência interna foi medida através do alfa (α de Cronbach; a confiabilidade com o coeficiente de correlação intraclasse (CCI e a concordância pelo teste de plotagem Bland and Altman, com nível de significância de 5%. A percepção dos indivíduos sobre suas saúdes teve uma tendência positiva em 83,3% dos domínios do PSN (média > 50 pontos, exceto para o domínio "habilidades físicas" que variou entre 41,5 e 50 pontos. O instrumento obteve boa consistência interna, com α entre 0,81 e 0,87; excelente confiabilidade nos domínios "dor" e "habilidades físicas", ICC >0,90 (p This article seeks to evaluate the reliability, internal consistency and accuracy of the Nottingham Health Profile (NHP, namely a quality of life (QL instrument for individuals after suffering a stroke. This cross-sectional study was carried out in the communities of Recife in the State of Pernambuco. The sample was composed of 53 individuals at the chronic stroke phase. After checking the cognitive state, the NHP was applied. Descriptive statistics were employed for characterization of the sample; Cronbach's alpha (α coefficients were used for evaluation of internal consistency, and intra-class correlation coefficients (ICC were used for investigation of reliability, as well as consistency of the Bland and Altman plotting tests with 5% level of significance. Their perceptions of their own health were 83.3% positive for the majority of NHP criteria (average scores > 50

  18. Cronotipo e implicações para sua utilização na fisioterapia em pacientes com acidente vascular encefálico Chronotype and implications for its use in physical therapy in patients with stroke

    Directory of Open Access Journals (Sweden)

    Tania Fernandes Campos

    2011-09-01

    Full Text Available Na prática clínica, frequentemente o fisioterapeuta avalia e programa o tratamento do paciente sem levar em consideração a variação temporal de funções e comportamentos. O objetivo do estudo foi analisar a influência do cronotipo, padrão vigília-sono (qualidade do sono e sonolência excessiva e regularidade do estilo de vida na determinação do horário de preferência para a prática de atividades física e mental em pacientes com acidente vascular encefálico (AVE. Participaram 42 pacientes (61±9 anos no estágio crônico do AVE (18±21 meses e 12 indivíduos saudáveis (53±6 anos que responderam ao Questionário de Horne e Östberg (QHO, Índice de Qualidade do Sono de Pittsburgh (IQSP, Sonolência Excessiva de Epworth (SEE e o Social Rhythm Metric (SRM. Foi questionado em qual horário os participantes preferiam realizar atividade física (exercícios e mental (tarefas de raciocínio, considerando apenas seu bem-estar pessoal. Os dados foram analisados através do teste do χ2 e regressão múltipla. Dos pacientes avaliados, 93% eram matutinos, 64% apresentavam qualidade ruim do sono, 43% sonolência excessiva e 57% padrão irregular da rotina diária. Ao final da análise de regressão verificou-se que o cronotipo foi o único fator que teve influência no horário preferencial das atividades. Esses achados sugerem a necessidade da avaliação do cronotipo dos pacientes antes de se estabelecer um horário de atendimento na Fisioterapia.In clinical practice, the physical therapist often evaluates and programs the patient's treatment without taking into account the temporal variation of functions and behaviors. The aim of this study was to analyze the influence of the chronotype (morning type - evening type, sleep-wake state (sleep quality and excessive sleepiness and lifestyle regularity in determining the preferred time of day for physical and mental activities following stroke. Participants responded to the Morningness

  19. Avaliação da capacidade funcional de idosos com acidente vascular encefálico Evaluación de la capacidad funcional de adultos mayores con accidente vascular encefálico Evaluation of functional capaciy in elders with encephalic vascular accident

    Directory of Open Access Journals (Sweden)

    Keila Cristianne Trindade da Cruz

    2009-10-01

    Full Text Available OBJETIVO: Avaliar a capacidade funcional de idosos com acidente vascular encefálico (AVE e verificar a relação, bem como a influência de variáveis sociodemográficas e de saúde na capacidade funcional desses sujeitos. MÉTODOS: Foram realizadas entrevistas com 44 idosos, vítimas de AVE, durante o atendimento nos locais de coleta de dados. O instrumento de coleta de dados contemplou dados sociodemográficos e clínicos. Para avaliar a capacidade funcional dos sujeitos foi aplicado o instrumento de Medida de Independência Funcional (MIF. RESULTADOS: Houve predomínio da faixa etária entre 60 e 69 anos. A MIF apresentou boa consistência interna. A pontuação total MIF dos apresentou média de 97,0. Os pacientes com acesso ao serviço de saúde apresentaram valores superiores aos dos indivíduos que não tinham acesso (Teste de Mann-Whitney. Foi observada correlação negativa entre a MIF e seus domínios e a idade (Pearson. CONCLUSÃO: O AVE causou alteração na capacidade funcional dos sujeitos da pesquisa, o que aponta para a necessidade de se investir em estratégias de reabilitação que venham a amenizar as perdas funcionais advindas da própria idade e, principalmente, das seqüelas de AVE.OBJETIVO: Evaluar la capacidad funcional de personas adultas mayores con accidente vascular encefálico (AVE y verificar la relación, así como la influencia de variables sociodemográficas y de salud en la capacidad funcional de esos sujetos. MÉTODOS: Fueron entrevistadas 44 personas adultas mayores, víctimas de AVE, durante la atención en los locales de recolección de datos. El instrumento de recolección de datos incluyó datos sociodemográficos y clínicos. Para evaluar la capacidad funcional de los sujetos se aplicó el instrumento de Medida de Independencia Funcional (MIF. RESULTADOS: Hubo predominio del grupo etáreo comprendido entre 60 y 69 años. La MIF presentó buena consistencia interna. La puntuación total de la MIF present

  20. CT features on increased cerebral vascular density and its pathological mechanism in patients with cyanotic congenital disease

    International Nuclear Information System (INIS)

    Objective: To investigate CT features on increased cerebral vascular density and its pathological mechanism in patients with cyanotic congenital heart disease (CCHD). Methods: Preoperative brain CT scan and clinical data in 82 patients suffering from CCHD were analyzed. According to the increased levels of vascular density, patients were divided into 4 groups: normal, mild, moderate and severe. Relationships between the increased levels of vascular density and Hb, RBC, HCT, as well as the degree of cyanosis,were studied. AVONA was carried out to test blood CT value of cerebral sinuses, Hb, RBC and HCT in different groups. Descriptive analysis and linear regression were adopted to study the correlation between blood CT value and Hb concentration. The relationship of increased vascular density to degrees of cyanosis was analysed by Spearman. Results: Among 82 patients, 12 patients (14.6%) were found in the group of normal vascular density and 70 patients (85.4%) in the increased vascular density group. Among 70 patients with increased vascular density, 22 patients (26.8% ) with (55.4 ± 2.6) HU, (169 ±6)g/L of Hb, (5.8 ±0.3) × 1012/L of RBC and 0.51 ±0.03 of HCT, 29 patients (35.4%) with (61.3 ± 2.9) HU, (209 ± 15 ) g/L, (7.1 ± 0.4) × 1012/L, 0.66 ± 0.06 and 19 patients (23.2%) with (68.8 ± 4.2) HU, (242 ± 23) g/L, (8.3 ± 0.9) × 1012/L, 0.78 ± 0.08 were observed in the mild,moderate and severe group,respectively. There were significant differences in distribution of blood CT value (HU), Hb, RBC and HCT in different groups (F=163.263, 134.703, 120.974, 136.541; P<0.01). Blood CT value was positively correlated with Hb concentration (r=0.98, P<0.01). Vascular density was also positively correlated with the degree of cyanosis (r=0.86, P<0.01). Conclusions: Cerebral vascular density of patients suffering from CCHD presented different levels of increases based on CT scan results due to rise of RBC stimulated by anoxia. The increased level of vascular density

  1. Deviation from optimal vascular caliber control at middle cerebral artery bifurcations harboring aneurysms.

    Science.gov (United States)

    Baharoglu, Merih I; Lauric, Alexandra; Wu, Chengyuan; Hippelheuser, James; Malek, Adel M

    2014-10-17

    Cerebral aneurysms form preferentially at arterial bifurcations. The vascular optimality principle (VOP) decrees that minimal energy loss across bifurcations requires optimal caliber control between radii of parent (r₀) and daughter branches (r1 and r2): r₀(n)=r₁(n)+r₂(n), with n approximating three. VOP entails constant wall shear stress (WSS), an endothelial phenotype regulator. We sought to determine if caliber control is maintained in aneurysmal intracranial bifurcations. Three-dimensional rotational angiographic volumes of 159 middle cerebral artery (MCA) bifurcations (62 aneurysmal) were processed using 3D gradient edge-detection filtering, enabling threshold-insensitive radius measurement. Radius ratio (RR)=r₀(3)/(r₁(3)+r₂(3)) and estimated junction exponent (n) were compared between aneurysmal and non-aneurysmal bifurcations using Student t-test and Wilcoxon rank-sum analysis. The results show that non-aneurysmal bifurcations display optimal caliber control with mean RR of 1.05 and median n of 2.84. In contrast, aneurysmal bifurcations had significantly lower RR (0.76, pbifurcations revealed a daughter branch larger than its parent vessel, an absolute violation of optimality, not witnessed in non-aneurysmal bifurcations. The aneurysms originated more often off the smaller daughter (52%) vs. larger daughter branch (16%). Aneurysm size was not statistically correlated to RR or n. Aneurysmal males showed higher deviation from VOP. Non-aneurysmal MCA bifurcations contralateral to aneurysmal ones showed optimal caliber control. Aneurysmal bifurcations, in contrast to non-aneurysmal counterparts, disobey the VOP and may exhibit dysregulation in WSS-mediated caliber control. The mechanism of this focal divergence from optimality may underlie aneurysm pathogenesis and requires further study.

  2. Acidente vascular cerebral em pacientes jovens: análise de 164 casos Stroke in young adults: analysis of 164 patients

    Directory of Open Access Journals (Sweden)

    Viviane H. Flumignan Zétola

    2001-09-01

    Full Text Available Realizamos análise epidemiológica de 164 pacientes com AVC, cujo primeiro episódio ocorreu entre 15 e 49 anos de idade através de um estudo retrospectivo de pacientes ambulatoriais. O principal tipo de apresentação foi AVC isquêmico (AVCI em 141 pacientes, ocorrendo AVC hemorrágico (AVCH em16 casos e 7 pacientes com trombose venosa. A presença de fatores de risco aterotrombóticos foi prevalente, em 48,22% dos pacientes com AVCI sendo que a hipertensão arterial sistêmica (HAS, nos casos de AVCH, foi a etiologia mais frequente. Em 32% dos casos não se pode determinar a sua causa. Embora a população jovem possua determinantes diferentes e geralmente deva ter uma investigação etiológica mais abrangente, no grupo estudado foram prevalentes os fatores de risco conhecidos e potencialmente controláveis, sugerindo que campanhas de prevenção e detecção precoce devam ser incentivados.We retrospectively analyzed the epidemiological features of 164 out-clinic patients with a first-onset stroke between 15 and 49 years old. Ischemic stroke occurred in 141 patients, hemorrhagic stroke in 16 patients, and venous thrombosis in 7 patients. Forty-eight percent of ischemic strokes were atherothrombotic, but no etiology was found in 32% of patients with ischemic stroke. Systemic arterial hypertension was the most frequent etiology in the hemorrhagic stroke group. The most frequent risk factors were systemic arterial hypertension, smoking, hypercholesterolemia, alcoholism and diabetes mellitus. Although stroke in young adults deserves some specific etiological investigation, we found that ordinary risk factors such as hypertension, tabacco use, hypercolesteremia and diabetes were prevalent in our population. It seems that prevention campaigns should be the target of our work.

  3. The follow-up research on the value of the plasma homocystine after methionine loading test on the recurrent ischemic vascular event in cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    刘怀翔

    2014-01-01

    Objective To evaluate the effect of the plasma homocystine(Hcy)after methionine loading test(MLT)on the recurrence of ischemic vascular event,including cerebral infarction,transient ischemic attack(TIA),acute coronary syndrome,other vascular embolism in cerebral infarction patients.Methods The fasting plasma homocystine(FHcy)and homocystine after MLT(PHcy)levels were measured by high-performance liquid chromatog-

  4. Minocycline inhibits neuroinflammation and enhances vascular endothelial growth factor expression in a cerebral ischemia/reperfusion rat model

    Institute of Scientific and Technical Information of China (English)

    Zhiyou Cai; Yong Yan; Changyin Yu; Jun Zhang

    2008-01-01

    BACKGROUND: Brain ischemia involves secondary inflammation, which significantly contributes to the outcome of ischemic insults. Vascular endothelial growth factor (VEGF) may play an important role in the vascular response to cerebral ischemia, because ischemia stimulates VEGF expression in the brain, and VEGF promotes formation of new cerebral blood vessels. Minocyclinc, a tetracycline derivative, protects against cerebral ischemia and reduces inflammation, oxidative stress, and apoptosis.OBJECTIVE: To observe the influence of minocycline on VEGE interleukin-1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) expression in Wistar rats with focal cerebral ischemia/rcperfusion injury, and to study the neuroproteetion mechanism of minocycline against focal cerebral ischemia/rcpeffusion injury.DESIGN, TIME AND SETTING: Randomized, controlled experiment, which was performed in the Chongqing Key Laboratory of Neurology between March 2007 and March 2008.MATERIALS: A total of 36 female, Wistar rats underwent surgery to insert a thread into the left middle cerebral artery. Animals were randomly divided into sham-operation, minocyclinc treatment, and ischemia/reperfusion groups, with 12 rats in each group. Minocycline (Huishi Pharmaceutical Limited Company, China) was dissolved to 0.5 g/L in normal saline.METHODS: A 0.5- 1.0 cm thread was inserted into rats from the sham-operation group. Rats in the ischemia/reperfusion group underwent ischemia and reperfusion. The minocycline group received minocycline (50 mg/kg) 12 and 24 hours following ischemia and reperfusion, whereas the other groups received saline at the corresponding time points.MAIN OUTCOME MEASURES: mRNA and protein expression of IL-1β and TNF-α was measured by reverse transcriptase-polymerasc chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA), respectively. VEGF mRNA and protein expression was examined by RT-PCR, Western blot, and ELISA.RESULTS: Minocycline decreased the focal infarct

  5. No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin : The promise study

    NARCIS (Netherlands)

    S. Achterberg (Sefanja); L.J. Kappelle (Jaap); P.I.W. de Bakker (Paul); M. Traylor (Matthew); A. Algra (Ale); Y. van der Graaf (Yolanda); D.E. Grobbee (Diederick); G.E.H.M. Rutten (Guy); F.L.J. Visseren (Frank); F.L. Moll (Frans); W.P. Mali (Willem); P.A. Doevendans (Pieter); Martin, F. (Farrall); E.G. Holliday (Elizabeth); C. Sudlow (Cathie); J. Hopewell; Cheng, Y.-C. (Yu-Ching); M. Fornage (Myriam); M.K. Ikram (Kamran); R. Malik (Rainer); S. Bevan (Steve); U. Thorsteinsdottir (Unnur); A.L. DeStefano (Anita); B.B. Worrall (Bradford B.); Reiner, A.P. (Alex P.); B.D. Mitchell (Braxton); R. Clarke (Robert); C. Levi (Christopher); Seshadri, S. (Sudha); G. Boncoraglio (Giorgio Battista); Sharma, P. (Pankaj); J.C. Bis (Joshua); S. Gretarsdottir (Solveig); B.M. Psaty (Bruce); Rothwell, P.M. (Peter M.); J. Rosand (Jonathan); J.F. Meschia (James F.); K. Stefansson (Kari); C. Kubisch (Christian); H.S. Markus (Hugh)

    2015-01-01

    textabstractBackground: Patients who have suffered from cerebral ischemia have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that cerebral ischemia has a heritable component, genetic information might improv

  6. Escalas para avaliação da sobrecarga de cuidadores de pacientes com Acidente Vascular Encefálico Escalas para evaluación de la sobrecarga de cuidadores de pacientes con Accidente Vascular Encefálico Scales for evaluation of the overload of caregivers of patients with Stroke

    Directory of Open Access Journals (Sweden)

    Ana Railka de Souza Oliveira

    2012-10-01

    Full Text Available O objetivo do estudo foi avaliar as escalas disponíveis na literatura para medir a sobrecarga de cuidadores de pacientes acometidos por acidente vascular encefálico. Realizou-se uma revisão bibliográfica nas três bases de dados: LILACS, CINAHL e SCOPUS. Selecionaram-se 23 trabalhos e identificaram-se 24 diferentes escalas. Destas, as mais citadas foram o Caregiver Strain Index, a Caregiver Burden Scale, a Caregiver Reaction Assessment, o Sense of Competence Questionnaire, a Relatives Stress Scale e a Zarit Burden Interview. O uso de escalas para mensurar a sobrecarga é uma ferramenta importante para avaliar o contexto no qual está inserido o cuidador, entretanto é mais fidedigno quando associado a outros instrumentos de mensuração. Portanto, é fundamental pesquisas de validação de escalas para essa população.El objetivo de esto estudio fue evaluar las escalas disponibles en literatura para evaluar la sobrecarga de cuidadores de pacientes acometidos por accidente vascular encefálico. Una revisión bibliográfica fue desarrollada en tres bases de datos: LILAS, CINAHL y SCOPUS. En 23 trabajos seleccionados, 24 diferentes escalas fueron identificadas, siendo las principales: el Caregiver Strain Index, la Caregiver Burden Scale, el Caregiver Reaction Assessment, el Sense of Competence Questionnaire, la Relatives Stress Scale y la Zarit Burden Interview. El uso de escalas para mensurar sobrecarga es una herramienta importante en el contexto donde se inserta el cuidador. Es más confiable utilizar más que uno instrumento de mensuración. Por esto, la validación de escalas es importante para esta población.The objective of the study was to evaluate the available productions in literature about scales to measure the overload of caregivers of patients with stroke. It was carried out a bibliographical revision in three databases: LILACS, CINAHL and SCOPUS. In 23 works, 24 different scales were identified, and the most cited were: the

  7. Effect of isovolemic, isothermic hemodialysis on cerebral perfusion and vascular stiffness using contrast computed tomography and pulse wave velocity.

    Directory of Open Access Journals (Sweden)

    Ansgar Reising

    Full Text Available BACKGROUND: Patients undergoing hemodialysis treatment have a six-fold increased risk for stroke relative to the general population. However, the effect of hemodialysis on cerebral blood flow is poorly studied and confounding factors like blood pressure and ultrafiltration as well as temperature changes have rarely been accounted for. The aim of our study was to use state-of-the-art technology to evaluate the effect of a single dialysis session on cerebral perfusion as well as on vascular stiffness. METHODS: Chronic hemodialysis patients (7 male/3 female, mean age 58 years were recruited. Cerebral blood flow and arterial pulse wave velocity were measured before and immediately after a hemodialysis session. To exclude effects of volume changes we kept ultrafiltration to a minimum, allowing no change in body weight. Isothermic conditions were maintained by using the GENIUS single-pass batch-dialysis system with a high-flux polysulfone dialyser. Cerebral blood flow was measured by contrast-enhanced computed tomography. Pulse wave velocity was measured using the SphygmoCor (AtCor Medical, USA device by a single operator. RESULTS: This study shows for the first time that isovolemic, isothermic hemodialysis neither affected blood pressure or heart rate, nor total or regional cerebral perfusion. There was also no change in pulse wave velocity. CONCLUSIONS: Mechanisms other than the dialysis procedure itself might be causative for the high incidence of ischemic strokes in this patient population. Moreover, the sole removal of uremic toxins does not lead to short-term effects on vascular stiffness, underlying the importance of volume control in this patient population.

  8. Vasculite cerebral e uso de cocaína e crack Cerebral vasculitis and cocaine and crack abuse

    Directory of Open Access Journals (Sweden)

    Fernando Madalena Volpe

    1999-09-01

    Full Text Available O abuso de cocaína e crack está associado com importante parcela dos acidentes vasculares cerebrais, especialmente em pacientes jovens. O presente estudo relata o caso de um usuário de cocaína e crack que desenvolveu vasculite do sistema nervoso central, resultando em infartos cerebrais e edema extensos, levando à demência com alterações comportamentais e convulsões. Ressalta-se a importância de suspeitar do uso de drogas em jovens que se apresentam com acidente vascular cerebral, assim como avaliar possíveis lesões cerebrais em usuários de drogas com deterioração cognitiva.Cocaine and crack abuse is strongly related to stroke, particularly in young patients. The present study reports the case of a cocaine and crack abuser who developed central nervous system vasculitis, resulting in extensive cerebral infarctions, leading to dementia, behavioural disturbances and seizures. The relevance of detecting drug abuse in young stroke patients is stressed. Assessing possible brain lesions in drug abusers with cognitive impairment is also important.

  9. Efeitos da sondagem nasogástrica em pacientes com acidente cerebrovascular e disfagia

    Directory of Open Access Journals (Sweden)

    Tahissa Frota Cavalcante

    2014-10-01

    Full Text Available O estudo teve por objetivo analisar os efeitos da sondagem gástrica em pacientes com acidente vascular cerebral e disfagia. Revisão sistemática da literatura, realizada em seis bases de dados, com os descritores stroke e intubation, gastrointestinal. Foram encontrados 120 estudos e selecionados três ensaios clínicos. Os resultados apontaram diferentes desfechos, entre os quais: aumento do nível sérico de albumina (gastrostomia, prognóstico ruim e risco de morte (gastrostomia, aumento das falhas no tratamento devido a bloqueio, deslocamento e reinserção da sonda nasogástrica, e aumento da incidência de hemorragia gastrointestinal (sonda nasogástrica. A partir dos resultados obtidos nesta revisão sistemática, ressaltam-se as seguintes evidências: a sondagem nasogástrica deve ser adotada precocemente como um método de alimentação enteral; as falhas do tratamento são mais comuns naqueles que utilizam a sonda nasogástrica como método de alimentação; os resultados relacionados à melhora do estado funcional dos pacientes foram semelhantes, independente do método de terapia nutricional empregado.

  10. Response of the sensorimotor cortex of cerebral palsy rats receiving transplantation of vascular endothelial growth factor 165-transfected neural stem cells

    Institute of Scientific and Technical Information of China (English)

    Jielu Tan; Xiangrong Zheng; Shanshan Zhang; Yujia Yang; Xia Wang; Xiaohe Yu; Le Zhong

    2014-01-01

    Neural stem cells are characterized by the ability to differentiate and stably express exogenous ge-nes. Vascular endothelial growth factor plays a role in protecting local blood vessels and neurons of newborn rats with hypoxic-ischemic encephalopathy. Transplantation of vascular endothelial growth factor-transfected neural stem cells may be neuroprotective in rats with cerebral palsy. In this study, 7-day-old Sprague-Dawley rats were divided into ifve groups: (1) sham operation (control), (2) cerebral palsy model alone or with (3) phosphate-buffered saline, (4) vascular en-dothelial growth factor 165 + neural stem cells, or (5) neural stem cells alone. hTe cerebral palsy model was established by ligating the letf common carotid artery followed by exposure to hypox-ia. Phosphate-buffered saline, vascular endothelial growth factor + neural stem cells, and neural stem cells alone were administered into the sensorimotor cortex using the stereotaxic instrument and microsyringe. Atfer transplantation, the radial-arm water maze test and holding test were performed. Immunohistochemistry for vascular endothelial growth factor and histology using hematoxylin-eosin were performed on cerebral cortex. Results revealed that the number of vas-cular endothelial growth factor-positive cells in cerebral palsy rats transplanted with vascular endothelial growth factor-transfected neural stem cells was increased, the time for ifnding water and the ifnding repetitions were reduced, the holding time was prolonged, and the degree of cell degeneration or necrosis was reduced. hTese ifndings indicate that the transplantation of vascu-lar endothelial growth factor-transfected neural stem cells alleviates brain damage and cognitive deifcits, and is neuroprotective in neonatal rats with hypoxia ischemic-mediated cerebral palsy.

  11. Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo

    Science.gov (United States)

    Jia, Yali; Alkayed, Nabil; Wang, Ruikang K.

    2009-07-01

    Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mouse brain upon traumatic brain injury (TBI), with the cranium left intact, for a period of two weeks on the same animal. We show the ability of OMAG to repeatedly image 3-D cerebral vasculatures during pre- and post-traumatic phases, and to visualize the changes of regulated CBF and the vascular plasticity after TBI. The results indicate the potential of OMAG to explore the mechanism involved in the rehabilitation of TBI.

  12. Vivendo o acidente vascular encefálico agudo: significados da doença para pessoas hospitalizadas Viviendo el accidente cerebrovascular agudo: significado de la enfermedad para personas hospitalizadas Experiencing acute stroke: the meaning of the illness for hospitalized patients

    Directory of Open Access Journals (Sweden)

    Samia Jardelle Costa de Freitas Maniva

    2013-04-01

    Full Text Available Objetivou-se compreender o significado da experiência vivenciada pela pessoa adoecida por acidente vascular encefálico agudo. Trata-se de estudo qualitativo, fundamentado nos pressupostos teóricos do interacionismo simbólico, realizado em uma unidade especializada no tratamento de acidente vascular encefálico de um hospital terciário, situado na cidade de Fortaleza, CE. Participaram do estudo 10 pacientes. A coleta de dados ocorreu por meio de entrevista aberta e os dados foram organizados e analisados segundo a técnica de enunciação. Cumpriram-se todos os aspectos éticos. O significado da experiência de adoecimento foi construído com base na percepção dos sentimentos surgidos durante a hospitalização, caracterizados por medo da morte e das sequelas da doença; tristeza pelo distanciamento do lar; alívio, ao evidenciar-se melhora do quadro clínico, e desejo de mudança dos hábitos de vida. Apreendeu-se que a experiência de adoecimento por acidente vascular encefálico é complexa, e nela os significados são elaborados com base em sentimentos, ações e comportamentos dos sujeitos.Se objetivó comprender el significado de la experiencia de la persona que padeció accidente cerebrovascular agudo. Estudio cualitativo, fundamentado en los presupuestos teóricos del interaccionismo simbólico, realizado en unidad especializada en tratamiento de accidente cerebrovascular de un hospital terciario en Fortaleza-CE. Participaron diez pacientes. Datos recolectados mediante entrevista abierta, organizados y analizados según técnica de enunciación. Se cumplió con todos los aspectos éticos. El significado de la experiencia del padecimiento fue construido en base a la percepción de los sentimientos surgidos durante la internación, caracterizados por el miedo a la muerte y a las secuelas de la enfermedad; tristeza por alejarse del hogar; alivio al evidenciarse mejoras del cuadro clínico; e intención de cambio de hábitos de vida

  13. Expression of cyclin-dependent protein kinase 5 in the hippocampus of vascular dementia mice after cerebral ischemia and reperfusion

    Institute of Scientific and Technical Information of China (English)

    Tianjun Wang; Peiyuan Lü; Hezhen Zhang; Hebo Wang; Wei Jin; Zongcheng Guo; Changlin Liu

    2009-01-01

    BACKGROUND: The p25-activated cyclin-dependent protein kinase 5 (Cdk5) may induce neuronal cell death and cause the development of dementia following cerebral ischemia and reperfusion. OBJECTIVE: To observe changes in the expression of Cdk5 and p25 in hippocampal tissue of vascular dementia mice at different time points following cerebral ischemia and reperfusion. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment was performed in the clinical trial center of Hebei Provincial People's Hospital between September 2007 and October 2008.MATERIALS: Cdk5 rabbit anti-mouse polyclonal antibody, p35 rabbit anti-mouse polyclonal antibody, and β-actin mouse monoclonal antibody were purchased from Santa Cruz Biotechnology, Inc., USA; horseradish peroxidase-labeled goat anti-rabbit IgG and horseradish peroxidase-labeled goat anti-mice IgG were offered by Beijing Zhongshan Goldenbridye Biotechnology Co.,Ltd., China; the protein quantitative kit was produced by Applygen Gene Technology Corp., Beijing, China; cDNA reverse transcription and PCR amplification reagents were products of TianGen&Biotech (Beijing) Co.,Ltd., China.METHODS: One hundred and sixty male Kunming mice were randomly divided into two groups: a sham-operated group (n=65) and a model group (n=95). Vascular dementia was induced with three periods of transient ischemia and reperfusion of the bilateral common carotid arteries. In the sham-operated group, the bilateral common carotid arteries were not blocked.MAIN OUTCOME MEASURES: Behavioral tests were done at four and six weeks post surgery. Pathological changes in the hippocampal CA1 region were observed with hematoxylin-eosin staining. Cdk5 mRNA expression was examined by RT-PCR, and Western blots were used to evaluate Cdk5 and p25 expression. Learning and memory performance were assayed using the Morris water maze. RESULTS: Vascular dementia reduced learning and memory performance at 4 and 6 weeks post surgery. Vascular dementia also caused

  14. The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy

    Directory of Open Access Journals (Sweden)

    C. Moran

    2016-01-01

    Full Text Available It is uncertain whether small vessel disease underlies the relationship between Type 2 Diabetes Mellitus (T2DM and brain atrophy. We aimed to study whether retinal vascular architecture, as a proxy for cerebral small vessel disease, may modify or mediate the associations of T2DM with brain volumes. In this cross-sectional study using Magnetic Resonance Imaging (MRI scans and retinal photographs in 451 people with and without T2DM, we measured brain volumes, geometric measures of retinal vascular architecture, clinical retinopathy, and MRI cerebrovascular lesions. There were 270 people with (mean age 67.3 years and 181 without T2DM (mean age 72.9 years. T2DM was associated with lower gray matter volume (p=0.008. T2DM was associated with greater arteriolar diameter (p=0.03 and optimality ratio (p=0.04, but these associations were attenuated by adjustments for age and sex. Only optimality ratio was associated with lower gray matter volume (p=0.03. The inclusion of retinal measures in regression models did not attenuate the association of T2DM with gray matter volume. The association of T2DM with lower gray matter volume was independent of retinal vascular architecture and clinical retinopathy. Retinal vascular measures or retinopathy may not be sufficiently sensitive to confirm a microvascular basis for T2DM-related brain atrophy.

  15. Environmental pollutants and stroke-related hospital admissions Poluentes ambientais e internações devido a acidente vasculoencéfalico

    Directory of Open Access Journals (Sweden)

    Luiz Fernando Costa Nascimento

    2012-07-01

    Full Text Available Some effects of environmental pollution on human health are known, especially those affecting the respiratory and cardiovascular systems. The current study aimed to estimate these effects on the production of hospital admissions for stroke. This was an ecological study using hospital admissions data in São José dos Campos, São Paulo State, Brazil, with diagnosis of stroke, from January 1, 2007, to April 30, 2008. The target pollutants were particulate matter, sulfur dioxide, and ozone. Use of a Poisson linear regression model showed that same-day exposure to particulate matter was associated with hospitalization for stroke (RR = 1.013; 95%CI: 1.001-1.025. An increase of 10µg/m³ in this pollutant increased the risk of hospitalization by 12% (RR = 1.137; 95%CI: 1.014-1.276. In the multi-pollutant model, it was thus possible to identify particulate matter as associated with hospitalization for stroke in a medium-sized city like São José dos Campos.Alguns dos efeitos da poluição ambiental na saúde humana são conhecidos, destacando aqueles nos sistemas respiratório e cardiovascular. Este trabalho tem por objetivo estimar esses efeitos na gênese das internações por acidente vasculoencefálico. Foi um estudo ecológico realizado com dados de internações da cidade de São José dos Campos, São Paulo, Brasil, relativos aos diagnósticos de acidente vascular cerebral, entre 1º de janeiro de 2007 e 30 de abril de 2008. Os poluentes estudados foram material particulado, dióxido de enxofre e ozônio. Utilizando-se de modelo linear generalizado da regressão de Poisson, foi possível identificar exposição ao material particulado, no mesmo dia, como associado à internação por acidente vasculoencefálico (RR = 1,013; IC95%: 1,001-1,025. O aumento de 10µg/m3 desse poluente aumenta o risco de internação em 12% (RR = 1,137; IC95%: 1,014-1,276. Assim, foi possível identificar o material particulado, no modelo multipoluente, como

  16. Determination of Vascular Reactivity of Middle Cerebral Arteries from Stroke and Spinal Cord Injury Animal Models Using Pressure Myography.

    Science.gov (United States)

    Anwar, Mohammad A; Eid, Ali H

    2016-01-01

    Stroke and other neurovascular derangements are main causes of global death. They, along with spinal cord injuries, are responsible for being the principal cause of disability due to neurological and cognitive problems. These problems then lead to a burden on scarce financial resources and societal care facilities as well as have a profound effect on patients' families. The mechanism of action in these debilitating diseases is complex and unclear. An important component of these problems arises from derangement of blood vessels, such as blockage due to clotting/embolism, endothelial dysfunction, and overreactivity to contractile agents, as well as alteration in endothelial permeability. Moreover, the cerebro-vasculature (large vessels and arterioles) is involved in regulating blood flow by facilitating auto-regulatory processes. Moreover, the anterior (middle cerebral artery and the surrounding region) and posterior (basilar artery and its immediate locality) regions of the brain play a significant role in triggering the pathological progression of ischemic stroke particularly due to inflammatory activity and oxidative stress. Interestingly, modifiable and non-modifiable cardiovascular risk factors are responsible for driving ischemic and hemorrhagic stroke and spinal cord injury. There are different stroke animal models to examine the pathophysiology of middle cerebral and basilar arteries. In this context, arterial myography offers an opportunity to determine the etiology of vascular dysfunction in these diseases. Herein, we describe the technique of pressure myography to examine the reactivity of cerebral vessels to contractile and vasodilator agents and a prelude to stroke and spinal cord injury. PMID:27604741

  17. Effect of large decompressive craniectomy combined with vascular reconstruction on cerebral perfusion in patients with severe brain injury

    Directory of Open Access Journals (Sweden)

    Liang-zhen HUANG

    2015-11-01

    Full Text Available Objective To compare the efficacies of large decompressive craniectomy combined with vascular reconstruction and traditional decompressive craniectomy in treatment of severe brain injury. Methods Forty-eight patients with severe brain injury, which was dominated by brain contusion to the frontoparietal lobes, admitted to our hospital from March 2012 to March 2014 were divided equally into experimental group and control group. The patients in the experimental group underwent large decompressive craniectomy combined with vascular reconstruction, and the patients in the control group received traditional decompressive craniectomy. The hemodynamic changes including cerebral blood flow (CBF, cerebral blood volume (CBV, mean transit time (MTT, time to peak (TTP and the ratios of these values (rCBF, rCBV, rMTT and rTTP on two sides were observed by CT perfusion imaging, and the Glasgow outcome score (GOS was analyzed 6 months after operation. Results The CBF and CBV scores in experimental group were higher than those in the control group at 1 week and 1 month after the operation (P0.05. The rate of satisfactory recovery (including good recovery and moderate disability was higher in the experimental group than in the control group, while the rate of poor recovery (including severe disability, vegetative state and death was lower in the experimental group than in the control group (P<0.05. Conclusion The large decompressive craniectomy combined with vascular reconstruction can not only decrease the intracranial pressure, but also recover the blood supply of brain, thus deserving the clinical application and popularization. DOI: 10.11855/j.issn.0577-7402.2015.11.15

  18. Characteristics of Cerebral Blood Flow in Vascular Dementia using SPM Analysis Compared to Normal Control and Alzheimer's Dementia

    International Nuclear Information System (INIS)

    Cerebral perfusion pattern of vascular dementia (VD) was not well established and overlap of cerebral perfusion pattern was reported between VD and Alzheimer's dementia (AD). The aim of this study is to assess the specific patterns of SPECT finding in VD compared with normal control subjects and to disclose differences of cerebral blood flow between subjects with VD and AD were investigated using statistic parametric mapping analysis. Thirty-two VD (mean age ; 67.86.4 years, mean CDR ; 0.980.27), 51 AD (mean age ; 71.47.2 years, CDR ; 1.160.47), which were matched for age and severity of dementia, and 30 normal control subjects (mean age ; 60.17.7 years) participated in this study. The Tc-99m HMPAO brain perfusion SPECT data were analyzed by SPM99. The SPECT data of the patients with VD were compared to those of the control subjects and then compared to the patients with AD. SPM analysis of the SPECT image showed significant perfusion deficits in the both frontal (both cingulate gyrus, both inferior frontal gyrus, B no.47, right frontal rectal gyrus, left frontal subcallosal gyrus, B no.25), both temporal (right insula, B no.13, left superior temporal gyrus, left parahippocampal gyrus, B no.35), occipital (occipital lingual gyrus), right corpus callosum and right cerebellar tonsil regions in subjects with VD compared with normal control subjects (uncorrected p<0.01). Comparison of the two dementia groups (uncorrected p<0.01) revealed significant hypoperfusion in both parietal posterior central gyrus, right inferior frontal gyrus (B no.47), left insula, right thalamus (ventral lateral nucleus), right claustrum and right occipital cuneus regions in VD group compared with AD. There were no typical confined regional hypoperfusion areas but scattered multiple perfusion deficits in VD compared AD. These findings may be helpful to reflect the pathophysiological mechanisms of VD and to disclose differences of cerebral blood flow between subjects with VD and AD

  19. Vascular Function, Cerebral Cortical Thickness, and Cognitive Performance in Middle-Aged Hispanic and Non-Hispanic Caucasian Adults

    Science.gov (United States)

    Pasha, Evan; Kaur, Sonya S.; Gonzales, Mitzi M.; Machin, Daniel R.; Kasischke, Kennon; Tanaka, Hirofumi; Haley, Andreana P.

    2015-01-01

    Hispanics are at increased risk of acquiring cardiovascular risk factors that contribute to cognitive dysfunction. To compare indices of vascular health to measures of cerebral gray matter integrity, 60 middle-aged Hispanic and non-Hispanic Caucasian participants were matched across age, gender, years of education, and mental status. Arterial stiffness was characterized via β-stiffness index and carotid-femoral pulse-wave velocity, and magnetic resonance imaging estimated cortical thickness in a priori regions of interest known to be susceptible to vascular risk factors. Measures of arterial stiffness were significantly higher in Hispanics than in non-Hispanic Caucasians. Hispanics exhibited thinner left inferior frontal gyrus (LIFG) cortical thickness (p=0.04) with concurrently lower language (p=0.02), memory (p=0.03), and attention-executive functioning (p=0.02). These results suggest that compromised vascular health may occur simultaneously with cortical thinning of the LIFG as an early neuropathological alteration in Hispanics. PMID:25720950

  20. [Vascular parkinsonism].

    Science.gov (United States)

    Marxreiter, F; Winkler, J

    2016-07-01

    Parkinsonism may result from cerebral vascular disorders that feature white matter lesions and small vessel pathology. Vascular Parkinsonism typically presents as lower body Parkinsonism with predominant gait impairment. Urinary incontinence and cognitive decline are additional features of the disease. There is a considerable overlap between vascular Parkinsonism and vascular dementia. We review the clinical characteristics of vascular Parkinsonism and discuss the current treatment approaches, as well as the role of brain imaging for the diagnostic workup. . PMID:27299942

  1. Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia

    OpenAIRE

    Zhang, Wenri; Iliff, Jeffrey J.; Campbell, Caitlyn J; Wang, Ruikang K.; Hurn, Patricia D.; Alkayed, Nabil J.

    2009-01-01

    Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilator eicosanoids called epoxyeicosatrienoic acids (EETs), is sexually dimorphic and suppressed by estrogen. We determined if the sex difference in blood flow during focal cerebral ischemia is linked to sEH. Soluble epoxide hydrolase expression in brain, hydrolase activity in cerebral vessels, and plasma 14,15-dihydroxyeicosatrienoic acid (14,15-DHET) were determined in male and female wild-type (WT) and sEH knockout (sE...

  2. Cerebral vasoconstriction after subarachnoid hemorrhage--role of changes in vascular receptor phenotype

    DEFF Research Database (Denmark)

    Hansen-Schwartz, Jacob; Ansar, Saema; Edvinsson, Lars

    2008-01-01

    prominent given their ability to elicit powerful constriction of cerebral arteries. Investigating both 5-HT and ET receptors we have observed that there are distinct changes in receptor phenotype after experimental SAH, namely upregulation of the ETB and 5-HT1B receptors, and that this upregulation is...... linked to a higher sensitivity to the endogenous agonists. It has also been shown that reduction in regional cerebral blood flow (CBF) is associated with receptor upregulation and interventional animal experiments have shown a benefit from inhibiting the PKC and MAP kinase pathways on receptor...

  3. 急性脑梗死患者合并脑微出血的心脑血管事件发生的研究%Effect of cerebral microbleeds on cardiac and cerebral vascular events following acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    李晓晴; 毕齐; 王力; 王力峰

    2012-01-01

    目的 研究急性脑梗死合并脑微出血(CMB)患者后期心脑血管事件的发生率和危险因素.方法 将109例急性脑梗死患者分为CMB组38例和无CMB组71例,对其进行前瞻性研究,给予梯度回波T2* WI或磁敏感加权成像,并对患者的临床资料和影像学特点进行分析.平均随访(9.5±3.7)个月.结果 与无CMB组比较,CMB组脑梗死和脑出血两者兼有,单纯脑出血比例明显升高(7.9% vs 1.4%,P<0.05;10.5% vs 0,P<0.01).CMB组共检出CMB 153个.在随访中,16例患者再发脑卒中,包括11例脑梗死,5例脑出血.5例脑出血患者中有3例服用阿司匹林,2例接受抗凝治疗.CMB组有2例脑出血患者的出血部位与CMB部位相同.结论 CMB是脑微小血管病变特征之一;是急性缺血性脑血管病患者后期发生脑出血的危险因素之一;CMB对脑卒中患者长期服用阿司匹林或者抗凝治疗具有重要意义.%Objective To study the incidence and risk factor of cardiac and cerebral vascular events in patients with acute cerebral infarction accompanying cerebral mierobleeds(CMB). Methods One hundred and nine acute cerebral infarction patients were divided into CMB group(n = 38) and non-CMB group (n = 71). The patients underwent gradient echo T2-weighted MRI or magnetic susceptibility-weighted imaging. Their clinical data and imaging characteristics were analyzed. The patients were followed up for 9. 5 + 3. 7 months. Results The proportions of acute cerebral infarction and CMB were significantly higher in CMB group than in non-CMB group(7. 9% vs 1.4%,P<0. 05)10. 5% vs 0,P<0.01).One hundred and fifty-three CMB were detected in CMB group. Of the 16 patients who had relapse of cerebral stroke during the follow-up, 11 had cerebral infarction and 5 had intracerebral hemorrhage(3 were treated with aspirin and 2 received anti-coagulant therapy). The bleeding site was similar to that of CMB in 2 patients of CMB group. Conclusion CMB are one of the

  4. Tratamento cirúrgico das patologias vasculares cerebrais nos pacientes epilépticos Surgical treatment of cerebral vascular pathologies in epiletic patients

    Directory of Open Access Journals (Sweden)

    Aziz Rassi-Neto

    1997-09-01

    Full Text Available A cirurgia das malformações arteriovenosas (MAV e dos cavernomas (angioma cavernoso na maioria das vezes é indicada após episódios de sangramento. Com o desenvolvimento das técnicas de diagnóstico e cirúrgicas na epilepsia de difícil controle, passou a ser cada vez maior a indicação cirúrgica destas lesões vasculares. Apresentamos nove pacientes com lesões vasculares cerebrais e crises muito frequentes, apesar do tratamento clínico adequado. A faixa etária variou de 12 a 42 anos de idade, com média de 25 anos; houve prevalência no sexo masculino (2:1. A cirurgia consistiu na exérese da lesão em todos os casos. Em quatro casos houve também ressecção da área irritativa perilesional, que foi demostrada pela eletrocorticografia. O estudo anatomopatológico das lesões mostrou cinco casos de cavernoma, três de MAV e um de angioma venoso. Quanto à localização, observamos três lesões no lobo temporal, quatro no frontal e duas na região parietal. O acompanhamento ambulatorial mostrou redução das crises em todos os pacientes, sendo que sete evoluíram sem crises após a cirurgia.Surgery of arteriovenous malformations (AVM and of cavernous angiomas (cavernoma in the majority of cases is indicated subsequently to episodes of bleeding. With the development of techniques for diagnosis and surgery for epilepsy of difficult control, indication for surgery of these vascular lesions has become greater. We present nine patients with cerebral vascular lesions and very frequent crises in spite of adequate clinical treatment. Ages ranged from 12 to 42 years with an average of 25 years; there was a prevalence of the male sex (2:1. Surgery consisted of exeresis of the lesion in all cases and in four there was also resection of the perilesional irritative area shown by electrocorticography. The pathologic study of lesions showed five cases of cavernoma, three cases of AVM, and one case of venous angioma. As to localization, we observed

  5. Cerebral vasoconstriction after subarachnoid hemorrhage--role of changes in vascular receptor phenotype

    DEFF Research Database (Denmark)

    Hansen-Schwartz, J.; Ansar, S.; Edvinsson, L.

    2008-01-01

    linked to a higher sensitivity to the endogenous agonists. It has also been shown that reduction in regional cerebral blood flow (CBF) is associated with receptor upregulation and interventional animal experiments have shown a benefit from inhibiting the PKC and MAP kinase pathways on receptor...

  6. 1H-magnetic resonance spectroscopy of vascular endothelial growth factor-induced neuroprotection following acute cerebral ischemia and reperfusion

    Institute of Scientific and Technical Information of China (English)

    Li Yi; Haiou Zhang; Hao Lei; Li Wei

    2008-01-01

    BACKGROUND: It has become generally accepted that measuring N-acetyI-L-aspartic acid through the use of 1H-magnetic resonance spectroscopy (1H-MRS) could be used to evaluate neuronal injury. OBJECTIVE: To study metabolic changes of N-acetyl-L-aspanic acid surrounding the acute cerebral ischcmia area following vascular endothelial growth factor (VEGF) treatment using 1H-MRS imaging, and to evaluate the neuroprotective effects of VEGE.DESIGN, TIME AND SETTING: Randomly controlled animal study, according to one-factor analysis of variance, was performed at the Shenzhen Hospital of Peking University and State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences from August 2003 to December 2005.MATERIALS: Twelve healthy, adult, Sprague Dawley rats were used to establish an ischemia/reperfusion model through the use of middle cerebral artery occlusion. The 4.7T superconducting nuclear magnetic resonance meter was provided by Brucker Company. VEGF164 was purchased from Shenzhen Jingmei Bioengineering Co., Ltd. Titus ancsthesia machine was purchased from Draeger Medical AG & Co. KG.METHODS: The rats were randomly divided into model control (n = 6) and VEGF-injected (n = 6) groups. All animals received 60-minute middle cerebral artery occlusion and 24-hour repcrfusion. Lateral cerebral ventricle injection was performed by stereotaxic technique at respective time points. The VEGF group received 0. 1 μ g/μ L VEGF (5 μL), and the model group received the same amount of normal saline, once daily for 3 days.MAIN OUTCOME MEASURES: Metabolic changes of N-acetyl-L-aspartic acid and lactic acid following cerebral ischemia and reperfusion were detected using 1H-MRS, and the ischemic volume was measured.RESULTS: Twelve rats were included in the final analysis. =H-MRS results revealed that the ischemic volume increased in the control group compared with prior to injection (P < 0.01). In the

  7. Assessment of cerebral haemodynamics and vascular reserve in patients with symptomatic carotid artery occlusion: an integrated MR method

    Energy Technology Data Exchange (ETDEWEB)

    Griffiths, P.D.; Wilkinson, I.D. [Royal Hallamshire Hospital, Unit of Academic Radiology, Sheffield (United Kingdom); Gaines, P.; Cleveland, T.; Beard, J. [Northern General Hospital, Vascular Institute, Sheffield (United Kingdom); Venables, G. [Royal Hallamshire Hospital, Neurology Department, Sheffield (United Kingdom)

    2005-03-01

    We describe an MR-based methodology designed to study cerebral haemodynamic compromise in patients with symptomatic carotid occlusions. We present the results of eight patients who underwent MR angiography of the cervical carotids and circle of Willis, MR imaging of the brain and dynamic gadolinium MR perfusion studies before and after the injection of the carbonic anhydrase inhibitor acetazolamide. All patients showed increased transit times in the symptomatic hemisphere at rest indicating reduced flow. The transit time asymmetries became more pronounced after acetazolamide in all patients because of failed vasodilatation on the affected side. There was an inverse correlation between the degree of increased transit time and the degree of collateralisation around the circle of Willis. We believe that demonstration of both macroscopic vascular anatomy and microvascular reserve is important when assessing patients with possible low-flow states and the described method is a robust means of obtaining that data. (orig.)

  8. Influence of the gender on cerebral vascular diameters observed during the magnetic resonance angiographic examination of willis circle

    Directory of Open Access Journals (Sweden)

    Marco Antonio Stefani

    2013-02-01

    Full Text Available The present study evaluated the calibers and anatomic configurations based on the Magnetic Resonance analysis (MRA, assaying the cerebral vascular territories and sex-linked variations. A randomized sample of 30 angiographic examinations in adult patients of both sexes was obtained and components of the circle of Willis were identified. Branch diameters were measured on a transversal cut 5mm from the vessel origin in a typical angiographic frontal incidence. For the comparative statistical analysis, tests were divided in the groups considering the patients' sex and age. The classical Circle of Willis configuration was oberved in only 15 samples (50%. Greater calibers were observed in the arteries of the posterior circulation and multiple linear regression analysis established that the caliber of the posterior circulation was influenced by an independent variable related to the gender. Additional variations included unilateral and bilateral fetal and hypoplasic Posterior communicating arteries. In the anterior cerebral artery (ACA, the presence of an accessory developed ACA, an ACA giving branches to the distal portion of the two hemispheres and a third median ACA the variants were observed. Gender influenced the variations on internal diameters of posterior circulation vessels, with larger measurements in men.

  9. Vitamin D status and vascular dementia due to cerebral small vessel disease in the elderly Asian Indian population.

    Science.gov (United States)

    Prabhakar, Puttachandra; Chandra, Sadanandavalli Retnaswami; Supriya, Manjunath; Issac, Thomas Gregor; Prasad, Chandrajit; Christopher, Rita

    2015-12-15

    Vitamin D plays vital roles in human health and recent studies have shown its beneficial effect on brain functioning. The present study was designed to evaluate the association of vitamin D with vascular dementia (VaD) due to cerebral small vessel disease (SVD) in Asian Indian population. 140 VaD patients aged ≥ 60 years with neuroimaging evidence of SVD, and 132 age and gender-matched controls, were investigated. Vitamin D status was estimated by measuring serum 25-hydroxy vitamin D. Logistic regression model revealed that deficient levels of vitamin D (vitamin D deficiency and insufficiency (12-20 ng/ml), the odds were increased to 31.6-fold and 14.4-fold, respectively. However, in hypertensives with vitamin D sufficiency (>20 ng/ml), the odds of VaD were increased by 3.8-fold only. Pearson correlation showed that serum vitamin D was inversely associated with systolic and diastolic blood pressure (r=-0.401 and -0.411, pvitamin D-deficient subjects. Since the combined presence of hypertension and vitamin D deficiency increases the probability of developing VaD, screening for vitamin D status in addition to regular monitoring of blood pressure, could reduce the risk of VaD associated with cerebral SVD in the elderly Asian Indian subjects. PMID:26671097

  10. Reduced cerebral oxygen–carbohydrate index during endotracheal intubation in vascular surgical patients

    DEFF Research Database (Denmark)

    Fabricius-Bjerre, Andreas; Overgaard, Anders; Winther-Olesen, Marie;

    2015-01-01

    aortic surgery, arterial to internal jugular venous (a-v) concentration differences for oxygen versus lactate and glucose were determined from before anaesthesia to when the patient left the recovery room. Intravenous anaesthesia was supplemented with thoracic epidural anaesthesia for open aortic surgery......Brain activation reduces balance between cerebral consumption of oxygen versus carbohydrate as expressed by the so-called cerebral oxygen-carbohydrate-index (OCI). We evaluated whether preparation for surgery, anaesthesia including tracheal intubation and surgery affect OCI. In patients undergoing...... (n = 5) and infiltration with bupivacaine for endovascular procedures (n = 14). The a-v difference for O2 decreased throughout anaesthesia and in the recovery room (1.6 ± 1.9 versus 3.2 ± 0.8 mmol l(-1), mean ± SD), and while a-v glucose decreased during surgery and into the recovery (0.4 ± 0...

  11. Cine gamma-angiography. Aids for the diagnosis of cerebral vascular disease

    International Nuclear Information System (INIS)

    Gamma-angioencephalography allows in a simple examination, the bilateral visualization of the injection of the main cerebral vessels, the regional measurement of transit times and, if it occurs, the observation of the diffusion of the tracer in a lesion. These different steps of the investigation are described and its diagnostic value is discussed. Sup(99m)Tc is the radioisotope used. To increase the accuracy of the qualitative data obtained from the gamma camera, a data processing system is used. Regions of interest are selected over the carotid and cerebral middle arteries. Time function curves are generated for each region of interest. From mathematical models, some pathological aspects of transit curves can be explained

  12. Cerebral vascular effects of loading dose of dexmedetomidine: A Transcranial Color Doppler study

    OpenAIRE

    Appavoo Arulvelan; Sethuraman Manikandan; Hari Venkat Easwer; Kesavapisharady Krishnakumar

    2016-01-01

    Background: Dexmedetomidine has been widely used in critical care settings because of its property of maintaining stable hemodynamics and inducing conscious sedation. The use of dexmedetomidine is in increasing trend particularly in patients with neurological disorders. Very few studies have focused on the cerebral hemodynamic effects of dexmedetomidine. This study is aimed to address this issue. Methods: Thirty patients without any intracranial pathology were included in this study. Middle c...

  13. Influence of mild hypothermia on vascular endothelial growth factor and infarct volume in brain tissues after cerebral ischemia in rats

    Institute of Scientific and Technical Information of China (English)

    Fei Ye; Gangming Xi; Biyong Qin; Shifeng Wang; Chengyan Li

    2006-01-01

    BACKGROUND: It has been demonstrated that mild hypothermia has obvious protective effect on both whole and local cerebral ischemia. However, the definite mechanism is still unclear for the brain protection of mild hypothermia on cerebral edema, inhibiting inflammatory reaction, stabilizing blood brain barrier, etc.OBJECTIVE: To investigate the effect of mild hypothermia on the expression of vascular endothelial growth factor and the infarct volume after cerebral ischemia in rats, and analyze the brain protective mechanism of mild hypothermia.DESIGN: A randomized grouping and controlled animal trial.SETTING: Department of Neurology, People's Hospital of Yunyang Medical College.MATERIALS: Twenty adult male SD rats of clean degree, weighing (250±30) g, were provided by the animal experimental center, School of Medicine, Wuhan University. The kits for SP immunohistochemistry were purchased from Beijing Zhongshan Golden Bridge Biotechnology Co., Ltd.METHODS: The experiments were carried out in the laboratory of Department of Neurology, Renmen Hospital of Wuhan University from May to July 2005. ① The 20 rats were divided randomly into normal temperature group (n =10) and mild hypothermia group (n =10). Models of permanent middle cerebral artery occlusion were established with modified nylon suture embolization. The rats were assessed with the Longa standards: O point for without nerve dysfunction; 1 for mild neurological deficit (fore claws could no extend completely); 2 for moderate neurological deficit (circling towards the affected side); 3 for severe neurological deficit (tilting towards the affected side); 4 for coma and unconscious; 1 -3 points represented that models were successfully established. The rats of the normal temperature group were fed at room temperature, and those in the mild hypothermia group were induced by hypothermia from 2 hours postoperatively, and the rectal temperature was kept at 34-35 ℃ for 72 hours. ② Measurement of infarct volume

  14. A functional electric orthesis on the paretic leg improves quality of life of stroke patients Órtese elétrica funcional usada no membro inferior parético melhora a qualidade de vida em pacientes com acidente vascular encefálico

    Directory of Open Access Journals (Sweden)

    Mara Renata Fernandes

    2006-03-01

    Full Text Available CONTEXT: Hemiparesia changes quality of life of patients with stroke making difficult a normal life. OBJECTIVE: To evaluate the effect of Functional Eletric Orthesis (FEO applied over the paretic leg in the quality of life of stroke patients. METHOD: The quality of life of 50 stroke patients of Associacao de Assistencia a Crianca Deficiente (AACD was evaluated with SF-36 questionnaire before and after the treatment with a FEO for rehabilitation of walking. We analyzed data according to gender and affected hemisphere. RESULTS: The average values from all domains of SF-36 improved significantly (pCONTEXTO: A hemiparesia altera a qualidade de vida de pacientes com acidente vascular encefálico (AVE dificultando uma vida normal. OBJETIVO: Avaliar o efeito da Órtese Elétrica Funcional (OEF colocada na perna parética, sobre a qualidade de vida de pacientes com AVE. MÉTODO: A qualidade de vida de 50 pacientes da AACD foi avaliada pelo questionário SF-36 antes e após o tratamento com OEF. Os dados foram analisados segundo sexo e lado do corpo acometido pelo AVE. RESULTADOS: As médias em todas as categorias do SF-36 foram significantemente maiores após tratamento com OEF (p<0,001. Pacientes do sexo feminino apresentaram resultados superiores aos do sexo masculino nos Aspectos Emocionais (p=0,04 e apresentaram tendência a melhora em Dor e Aspectos Sociais. Pacientes com hemiparesia direita obtiveram resultados superiores aos com hemiparesia esquerda nos Aspectos Emocionais (p=0,02. CONCLUSÃO: A utilização da OEF na perna parética por AVE é eficaz em melhorar a qualidade de vida dos pacientes.

  15. An Active Contour Model Based on Adaptive Threshold for Extraction of Cerebral Vascular Structures

    Science.gov (United States)

    Wang, Jiaxin; Zhao, Shifeng; Liu, Zifeng; Duan, Fuqing; Pan, Yutong

    2016-01-01

    Cerebral vessel segmentation is essential and helpful for the clinical diagnosis and the related research. However, automatic segmentation of brain vessels remains challenging because of the variable vessel shape and high complex of vessel geometry. This study proposes a new active contour model (ACM) implemented by the level-set method for segmenting vessels from TOF-MRA data. The energy function of the new model, combining both region intensity and boundary information, is composed of two region terms, one boundary term and one penalty term. The global threshold representing the lower gray boundary of the target object by maximum intensity projection (MIP) is defined in the first-region term, and it is used to guide the segmentation of the thick vessels. In the second term, a dynamic intensity threshold is employed to extract the tiny vessels. The boundary term is used to drive the contours to evolve towards the boundaries with high gradients. The penalty term is used to avoid reinitialization of the level-set function. Experimental results on 10 clinical brain data sets demonstrate that our method is not only able to achieve better Dice Similarity Coefficient than the global threshold based method and localized hybrid level-set method but also able to extract whole cerebral vessel trees, including the thin vessels. PMID:27597878

  16. An Active Contour Model Based on Adaptive Threshold for Extraction of Cerebral Vascular Structures.

    Science.gov (United States)

    Wang, Jiaxin; Zhao, Shifeng; Liu, Zifeng; Tian, Yun; Duan, Fuqing; Pan, Yutong

    2016-01-01

    Cerebral vessel segmentation is essential and helpful for the clinical diagnosis and the related research. However, automatic segmentation of brain vessels remains challenging because of the variable vessel shape and high complex of vessel geometry. This study proposes a new active contour model (ACM) implemented by the level-set method for segmenting vessels from TOF-MRA data. The energy function of the new model, combining both region intensity and boundary information, is composed of two region terms, one boundary term and one penalty term. The global threshold representing the lower gray boundary of the target object by maximum intensity projection (MIP) is defined in the first-region term, and it is used to guide the segmentation of the thick vessels. In the second term, a dynamic intensity threshold is employed to extract the tiny vessels. The boundary term is used to drive the contours to evolve towards the boundaries with high gradients. The penalty term is used to avoid reinitialization of the level-set function. Experimental results on 10 clinical brain data sets demonstrate that our method is not only able to achieve better Dice Similarity Coefficient than the global threshold based method and localized hybrid level-set method but also able to extract whole cerebral vessel trees, including the thin vessels. PMID:27597878

  17. Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment

    Science.gov (United States)

    Jing, Zhen; Shi, Changzheng; Zhu, Lihui; Xiang, Yonghui; Chen, Peihao; Xiong, Zhilin; Li, Wenxian; Ruan, Yiwen; Huang, Li'an

    2015-01-01

    Chronic cerebral hypoperfusion (CCH) induces cognitive impairment, but the compensative mechanism of cerebral blood flow (CBF) is not fully understood. The present study mainly investigated dynamic changes in CBF, angiogenesis, and cellular pathology in the cortex, the striatum, and the cerebellum, and also studied cognitive impairment of rats induced by bilateral common carotid artery occlusion (BCCAO). Magnetic resonance imaging (MRI) techniques, immunochemistry, and Morris water maze were employed to the study. The CBF of the cortex, striatum, and cerebellum dramatically decreased after right common carotid artery occlusion (RCCAO), and remained lower level at 2 weeks after BCCAO. It returned to the sham level from 3 to 6 weeks companied by the dilation of vertebral arteries after BCCAO. The number of microvessels declined at 2, 3, and 4 weeks but increased at 6 weeks after BCCAO. Neuronal degeneration occurred in the cortex and striatum from 2 to 6 weeks, but the number of glial cells dramatically increased at 4 weeks after BCCAO. Cognitive impairment of ischemic rats was directly related to ischemic duration. Our results suggest that CCH induces a compensative mechanism attempting to maintain optimal CBF to the brain. However, this limited compensation cannot prevent neuronal loss and cognitive impairment after permanent ischemia. PMID:25853908

  18. A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.

    Directory of Open Access Journals (Sweden)

    Jianhong Ye

    Full Text Available PURPOSE: To investigate radiation-induced carotid and cerebral vascular injury and its relationship with radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma (NPC patients. METHODS AND MATERIALS: Fifty eight NPC patients with radiation-induced temporal lobe necrosis (TLN were recruited in the study. Duplex ultrasonography was used to scan bilateral carotid arterials to evaluate the intima-media thickness (IMT and occurrence of plaque formation. Flow velocities of bilateral middle cerebral arteries (MCAs, internal carotid arteries (ICAs and basal artery (BA were estimated through Transcranial Color Doppler (TCD. The results were compared with data from 33 patients who were free from radiation-induced temporal lobe necrosis after radiotherapy and 29 healthy individuals. RESULTS: Significant differences in IMT, occurrence of plaques of ICAs and flow velocities of both MCAs and ICAs were found between patients after radiotherapy and healthy individuals (p<0.05. IMT had positive correlation with post radiation interval (p = 0.049. Compared with results from patients without radiation-induced TLN, the mean IMT was significantly thicker in patients with TLN (p<0.001. Plaques were more common in patients with TLN than patients without TLN (p = 0.038. In addition, flow velocities of MCAs and ICAs in patients with TLN were much faster (p<0.001, p<0.001. Among patients with unilateral TLN, flow velocity of MCAs was significantly different between ipsilateral and contralateral sides to the lesion (p = 0.001. CONCLUSION: Thickening of IMT, occurrence of plaque formation and hemodynamic abnormality are more common in patients after radiotherapy, especially in those with TLN, compared with healthy individuals.

  19. Clinical significance of measurement of plasma thromboxane B2 and 6-keto-prostaglandin F1α in patients with acute cerebral vascular accident

    International Nuclear Information System (INIS)

    Objective: To explore the clinical significance of the variations of plasma concentration of thromboxane B2(TXB2) and 6-keto-prostaglandin F1α (6-K-PGF1α) in patients with acute cerebral vascular accident. Methods: The plasma concentrations of TXB2 and 6-K-PGF1α in patients with acute cerebral infarction (n = 45) and patients with acute cerebral hemorrhage (n = 28) as wall as 40 controls were determined with radioimmunoassay (RIA). Results: Plasma concentration of TXB2 in patients with cerebral infarction were significantly higher than those in controls (p 1α levels were not much changed and T/P ratios (TXB2/6-K-PGF1α) were significantly increased (p 2 and 6-K-PGF1α levels were significantly increased (vs controls: p < 0.05), but T/P ratio remained unchanged. Conclusion: T/P increased obviously in patients with acute cerebral infarction, which suggested that anti-platelet aggregators might have remarkable effect on the treatment of acute cerebral infarction

  20. Características morfológicas da distribuição vascular cerebral de Sus scrofa Linnaeus (Mammalia, Artiodactyla Morphological characteristics of the cerebral vascular distribution of Sus scrofa Linnaeus (Mammalia, Artiodactyla

    Directory of Open Access Journals (Sweden)

    Jurandyr de A. Câmara Filho

    2004-12-01

    Full Text Available O objetivo do presente estudo foi verificar a vascularização arterial do encéfalo do javali, Sus scrofa Linnaeus, 1758, Suidae, e comparar com outras espécies. Cinco machos e cinco fêmeas foram injetados com látex colorido. O suprimento arterial do encéfalo foi descrito e análises morfológicas foram feitas. Nesta espécie o circuito arterial do encéfalo é formado por ramos da artéria carótida interna, como: as artérias comunicantes caudais, o ramo rostral, as artérias cerebrais rostrais, e artérias comunicantes rostrais.The aim this study was to verify the arterial vascularization of the wild boar brain, Sus scrofa Linnaeus, 1758, Suidae, and compare with other species. Five male and five female were injected with colored latex. The arterial supply of the brain was described and were done morphological analyses. In this species the arterial circuit of the brain is formed by the internal carotid artery branches, such as: the caudal communicant arteries, rostral branch, rostral cerebral arteries and rostral communicant arteries.

  1. Avaliação da aptidão cardiopulmonar em indivíduos com hemiparesia após acidente vascular encefálico Evaluación de la aptitud cardiopulmonar en individuos con hemiparesia tras accidente vascular encefálico Evaluation of cardiopulmonary fitness in individuals with hemiparesis after cerebrovascular accident

    Directory of Open Access Journals (Sweden)

    Angélica Cristiane Ovando

    2011-02-01

    Full Text Available FUNDAMENTO: Devido à hemiparesia, a avaliação da aptidão cardiorrespiratória de indivíduos após acidente vascular encefálico (AVE, por meio de testes ergométricos com protocolos convencionais, tem se tornado um desafio. OBJETIVO: Realizar teste cardiopulmonar (TCP em hemiparéticos para uma avaliação pré-participação visando uma criteriosa prescrição de exercício aeróbico. MÉTODOS: Participaram do estudo 8 indivíduos com hemiparesia crônica, que foram submetidos a TCP realizado com protocolo individualizado em rampa, desenvolvido a partir da informação da velocidade de marcha dos indivíduos previamente avaliados em teste de pista. Foi considerada a proposta de inclinação variando entre 0 e 10,0%, velocidade inicial correspondente a 70,0% do ritmo de caminhada confortável e velocidade máxima 40,0% superior à velocidade máxima no teste de pista, na expectativa de que o TCP, com este incremento gradativo e constante da intensidade, durasse entre 6 e 8 minutos. RESULTADOS: Em 100,0% dos avaliados, o motivo para a interrupção do teste foi fadiga periférica. O VO2 de pico alcançado foi de 20,6 ± 5,7 ml/kg.min. O Limiar I foi identificado em todos os exames, situando-se em 82,64 ± 4,78% da FC de pico e 73,31 ± 4,97% do VO2 de pico. O quociente respiratório (R do grupo foi de 0,96 ± 0,09, e três dos 8 indivíduos (37,5% atingiram R superior a 1,00, sendo o Limiar II identificado nestes sujeitos. Foram encontradas relações positivas entre variáveis do TCP e escores de equilíbrio, desempenho no teste de caminhada de 6 minutos e velocidade de marcha no solo. CONCLUSÃO: O teste mostrou ser útil para prescrição de atividade física nesses indivíduos.FUNDAMENTO: Debido a la hemiparesia, la evaluación de la aptitud cardiorrespiratoria de individuos después de accidente vascular encefálico (AVE, por medio de pruebas ergométricas con protocolos convencionales, se ha vuelto en un reto. OBJETIVO: Llevar a cabo

  2. MR imaging assessment of cerebral vascular disease: A combination of angiographic and parenchymal techniques

    International Nuclear Information System (INIS)

    This study tested the accuracy and clinical utility of a three-dimensional MR angiographic technique of the cervical carotids in combination with a routine spin-echo examination of the brain as a screening examination for cerebrovascular disease in 23 patients. The technique used a fast low-angle shot sequence with a reduced echo time and voxel size, gradient refocusing, and time of flight effects to minimize signal loss secondary to phase dispersion and maximize vessel contrast. Subsequent multiplanar three-dimensional reconstructions were obtained at 50 increments about the z-axis via ray-tracing linear thresholding algorithms. Examinations were compared with IV/IA-digital subtraction angiography or Doppler US as the objective of accuracy. Results of this ongoing study indicate that an MR angiographic screening examination can be coupled with routine brain MR imaging with only a 10-14 minute extension of examination time, providing both a vascular and a parenchymal evaluation

  3. Analyzing the Correlation between the Level of Serum Markers and Ischemic Cerebral Vascular Disease by Multiple Parameters

    Directory of Open Access Journals (Sweden)

    Laibin Dong

    2015-01-01

    Full Text Available Objective. To explore the serum markers associated with ischemic cerebral vascular disease (ICVD and discuss their diagnostic value. Methods. Two hundred and eighty-eight patients with ICVD and one hundred and eighty healthy persons were enrolled as the case group and the control group, respectively. This paper then carried out the univariate and multivariate logistic regression analyses of their respective levels of serum markers, made combined analysis of related factors, and detected the diagnostic value. Results. Meta-analysis results showed that for ICVD patients the levels of CRP, S-100, TNF-α, HCY, NSE, and IL-6 were higher than those of the healthy persons, while the level of HDL was obviously lower than that of the healthy persons. The multivariate regression analysis indicated that the association between the level of HDL and TNF-α and the occurrence of ICVD was statistically significant (P<0.05. The area under the curves (AUC of receiver operating characteristic (ROC curve of HDL and TNF-α was 0.916, with sensitivity of 90.91% and specificity of 76.47%. Conclusion. HDL has negative correlation with the occurrence of ICVD, while TNF-α was positively correlated with it. The combination test of HDL and TNF-α could raise the accuracy of ICVD diagnosis.

  4. Occult cerebral vascular malformation: High-field (2.0 T) MR imaging and comparison with CT

    International Nuclear Information System (INIS)

    Extensive experience with CT has led to the recognition of criteria for the diagnosis of occult cerebral vascular malformation. MR demonstrated all lesions as hemorrhage foci. The most common and typical MR findings of OVCM was circumscribed thick hypointense rim on T2-weighted images (T2-Wls) representing hemosiderin deposit with various central intensities suggesting the presence of hematomas in different stages (11 lesions). Among these. the recurrent hemorrhage in small amount produced the characteristic 'a bunch of grape' appearance. But, small OCVM less than 1 cm in diameter was identified as a small homogeneous hypointense nodule on T2-Wls with sharp (6 lesions) or fade-out (1 lesions) border. There were 2 lesions showing atypical findings such as dense hemosiderin rin with central lacuma or bilobed subacute hematoma. As the associated MR findings which strongly suggest the diagnosis of OCVM signal void due to feeding or draining vessels was found in 4, lesions and the surrounding focal cortical atrophy or leukomalacia in 2 lesions. The predilection site of OCVM was subcortical (8 lesions) and periventricular (6 cases) location. CT depicted 16 of the 20 lesions, but missed 4 lesions of small OCVM. CT alone did not permit definitive diagnosis of OCVM is most cases. Fifteen lesions demonstrated on CT contained somewhat hyperdense area in central or peripheral locations. Peripheral hyperdense area corresponded to the dense hemosiderin deposit on MR and central one to the hematoma formed by recent hemorrhage. Low density area on CT usually corresponded to liquefied subacute hematoma on MR

  5. Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

    Energy Technology Data Exchange (ETDEWEB)

    Li, X.; Zhang, R; Zhang, H; He, Y; Ji, W; Min, W; Boggon, T

    2010-01-01

    CCM3 mutations are associated with cerebral cavernous malformation (CCM), a disease affecting 0.1-0.5% of the human population. CCM3 (PDCD10, TFAR15) is thought to form a CCM complex with CCM1 and CCM2; however, the molecular basis for these interactions is not known. We have determined the 2.5 {angstrom} crystal structure of CCM3. This structure shows an all {alpha}-helical protein containing two domains, an N-terminal dimerization domain with a fold not previously observed, and a C-terminal focal adhesion targeting (FAT)-homology domain. We show that CCM3 binds CCM2 via this FAT-homology domain and that mutation of a highly conserved FAK-like hydrophobic pocket (HP1) abrogates CCM3-CCM2 interaction. This CCM3 FAT-homology domain also interacts with paxillin LD motifs using the same surface, and partial CCM3 co-localization with paxillin in cells is lost on HP1 mutation. Disease-related CCM3 truncations affect the FAT-homology domain suggesting a role for the FAT-homology domain in the etiology of CCM.

  6. Regional cerebral blood flow analysis of vascular dementia by the 133Xe inhalation method

    International Nuclear Information System (INIS)

    Eighty-one cases of ischemic cerebrovascular disease were investigated using the 133Xe inhalation method. Fifty-six were male and 25 were female. ages ranged from 25 to 84, with a mean age of 65.4 years. Thirty-two had cerebrovascular dementia and 49 had non dementia infarction. Two criteria were used for a diagnosis of cerebrovascular dementia: 1) the presense of cerebrovascular disease and 2) a score of less than 21.5 Hasegawa's dementia scale. By computed tomographic findings all cases were classified into three groups: lesion on a right hemisphere, a left hemisphere and bilateral hemispheres. Regional cerebral blood flow (rCBF) was calculated by 2-compartmental analysis and initial slope index method. The results are as follows: 1) Cases of cerebrovascular dementia tended to have a lower mean rCBF value. (p < 0.001). 2)rCBF patterns showed lower values in the central area for cases of laterality as determined by CT scan. 3) Both interhemispheric mean rCBF and mean rCBF classified from main lesion were no significant different between dementia group and non dementia group. 4) A comparison of mean rCBF with Hasegawa's dementia scale revealed a statistically significant correlation. (p < 0.001). (author)

  7. Single Sustained Inflation followed by Ventilation Leads to Rapid Cardiorespiratory Recovery but Causes Cerebral Vascular Leakage in Asphyxiated Near-Term Lambs.

    Directory of Open Access Journals (Sweden)

    Kristina S Sobotka

    Full Text Available A sustained inflation (SI rapidly restores cardiac function in asphyxic, bradycardic newborns but its effects on cerebral haemodynamics and brain injury are unknown. We determined the effect of different SI strategies on carotid blood flow (CaBF and cerebral vascular integrity in asphyxiated near-term lambs.Lambs were instrumented and delivered at 139 ± 2 d gestation and asphyxia was induced by delaying ventilation onset. Lambs were randomised to receive 5 consecutive 3 s SI (multiple SI; n = 6, a single 30 s SI (single SI; n = 6 or conventional ventilation (no SI; n = 6. Ventilation continued for 30 min in all lambs while CaBF and respiratory function parameters were recorded. Brains were assessed for gross histopathology and vascular leakage.CaBF increased more rapidly and to a greater extent during a single SI (p = 0.01, which then decreased below both other groups by 10 min, due to a higher cerebral oxygen delivery (p = 0.01. Blood brain barrier disruption was increased in single SI lambs as indicated by increased numbers of blood vessel profiles with plasma protein extravasation (p = 0.001 in the cerebral cortex. There were no differences in CaBF or cerebral oxygen delivery between the multiple SI and no SI lambs.Ventilation with an initial single 30 s SI improves circulatory recovery, but is associated with greater disruption of blood brain barrier function, which may exacerbate brain injury suffered by asphyxiated newborns. This injury may occur as a direct result of the initial SI or to the higher tidal volumes delivered during subsequent ventilation.

  8. Biorretroalimentação para treinamento do equilíbrio em hemiparéticos por acidente vascular encefálico: estudo preliminar Biofeedback for training of standing balance in post-stroke hemiparetic patients: a preliminary study

    Directory of Open Access Journals (Sweden)

    Antonio Vinicius Soares

    2009-06-01

    Full Text Available Como disfunções do equilíbrio são freqüentes nos pacientes hemiparéticos por acidente vascular encefálico (AVE, o treinamento do equilíbrio é meta fundamental em seu tratamento. O objetivo deste estudo preliminar foi verificar os efeitos da biorretroalimentação, por treinamento em plataforma instável computadorizada, em seis pacientes hemiparéticos por AVE (três homens e três mulheres, com idade média de 56,2 anos. Os pacientes foram avaliados, antes e após o tratamento, quanto a mobilidade funcional (pelo teste de levantar e caminhar cronometrado, TUGT na sigla em inglês, alcance funcional, qualidade de vida relacionada à saúde (pelo Perfil de Saúde de Nottingham e equilíbrio sobre prancha instável. O treinamento foi feito na mesma prancha, em 23 sessões de cerca de 30 minutos cada, durante oito semanas. Os resultados indicam melhora do equilíbrio, em média, de 119,1% com pés separados e de 79,6% com pés juntos (pSince balance dysfunction is frequent among poststroke hemiparetic patients, balance training is a fundamental goal in their rehabilitation. The purpose of this study was to assess the effects of biofeedback balance training on an unstable computerized platform in six hemiparetic patients (three men and three women, mean age 56,2 years old. Subjects were assessed, before and after treatment, as to functional mobility (by the timed up-and-go test, TUGT, functional reach, health-related quality of life (by the Nottingham health profile, and as to equilibrium on the unstable platform. The training on an unstable computerized platform took place along 23, 30-minute sessions for 8 weeks. Results showed significant improvement (p<0.001 in standing balance, of 119.1% with feet apart, and of 79.6% with feet together; a 15% increase (p<0.001 in functional reach; a 25.6% improvement in TUGT (p<0.001; and a slight improvement in self-reported quality of life. The program brought thus significant improvements for the

  9. Cinesioterapia previne ombro doloroso em pacientes hemiplégicos/paréticos na fase sub-aguda do acidente vascular encefálico Kinesiotherapy prevents shoulder pain in hemiplegic/paretic patients on sub-acute stage post-stroke

    Directory of Open Access Journals (Sweden)

    Agnes Irna Horn

    2003-09-01

    Full Text Available CONTEXTO: Ombro doloroso é freqüente em pacientes com hemiplegia/hemiparesia (H/P por acidente vascular encefálico (AVE, dificultando a recuperação neuromotora gerando incapacidade funcional. OBJETIVO: Estudar tratamento fisioterapêutico para a prevenção da dor no ombro com H/P em pacientes com AVE na fase sub-aguda, e analisar desfechos secundários (força muscular do ombro acometido e movimentos funcionais ativos básicos. MÉTODO: Estudaram-se 21 pacientes (12 homens, 9 mulheres; idades 26 a 87 anos com H/P. O tratamento fisioterapêutico consistiu de 30 minutos diários de cinesioterapia, desde as 48 horas após o AVE até a alta hospitalar. Os pacientes foram avaliados antes e após o tratamento em relação à presença ou ausência de dor no ombro H/P, à força dos diversos grupos musculares do ombro e quanto aos movimentos funcionais de transferência e manutenção postural básica. RESULTADOS: Nenhum paciente apresentava dor no ombro H/P na alta (pBACKGROUND: Painful shoulder is considered the most common complication of hemiplegic/parethic (H/P stroke patients. It is a negative factor for neuromotor recovery. PURPOSE: To study the effects of kinesiotherapy treatment on shoulder pain prevention, and as a secondary endpoints, to analyze muscle strength of H/P shoulder looking at basic functional active mobility. METHOD: Twenty one inpatients (12 men, 9 women aged 26 to 87 years, with post-stroke H/P were submitted to thirty minutes daily program kinesiotherapy, started at 48 hours post-stroke up to their hospital discharge. Patients were evaluated pre and post treatment according to the presence or absence of shoulder pain, movements and shoulder strength, and for presence or absence of basic functional movements. RESULTS: No patient complaining of shoulder pain at the hospital discharge (p<0.001. The muscle strength improved signifcantly for elevation, protusion, abduction and flexion of the shoulder (p<0.001. There was

  10. Occult cerebral vascular malformation: High-field (2.0 T) MR imaging and comparison with CT

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Kee Hyun; Chung, Jin Wook; Han, Moon Hee; Kang, Heung Sik; Han, Man Chung; Kim, Chu Wan [Seoul National Unversity College of Medicine, Seoul (Korea, Republic of)

    1989-02-15

    Extensive experience with CT has led to the recognition of criteria for the diagnosis of occult cerebral vascular malformation. MR demonstrated all lesions as hemorrhage foci. The most common and typical MR findings of OVCM was circumscribed thick hypointense rim on T2-weighted images (T2-Wls) representing hemosiderin deposit with various central intensities suggesting the presence of hematomas in different stages (11 lesions). Among these. the recurrent hemorrhage in small amount produced the characteristic 'a bunch of grape' appearance. But, small OCVM less than 1 cm in diameter was identified as a small homogeneous hypointense nodule on T2-Wls with sharp (6 lesions) or fade-out (1 lesions) border. There were 2 lesions showing atypical findings such as dense hemosiderin rin with central lacuma or bilobed subacute hematoma. As the associated MR findings which strongly suggest the diagnosis of OCVM signal void due to feeding or draining vessels was found in 4, lesions and the surrounding focal cortical atrophy or leukomalacia in 2 lesions. The predilection site of OCVM was subcortical (8 lesions) and periventricular (6 cases) location. CT depicted 16 of the 20 lesions, but missed 4 lesions of small OCVM. CT alone did not permit definitive diagnosis of OCVM is most cases. Fifteen lesions demonstrated on CT contained somewhat hyperdense area in central or peripheral locations. Peripheral hyperdense area corresponded to the dense hemosiderin deposit on MR and central one to the hematoma formed by recent hemorrhage. Low density area on CT usually corresponded to liquefied subacute hematoma on MR.

  11. The contribution of CXCL12-expressing radial glia cells to neuro-vascular patterning during human cerebral cortex development

    Directory of Open Access Journals (Sweden)

    Mariella eErrede

    2014-10-01

    Full Text Available This study was conducted on human developing brain by laser confocal and transmission electron microscopy to make a detailed analysis of important features of blood-brain barrier microvessels and possible control mechanisms of vessel growth and differentiation during cerebral cortex vascularization. The blood-brain barrier status of cortex microvessels was examined at a defined stage of cortex development, at the end of neuroblast waves of migration and before cortex lamination, with blood-brain barrier-endothelial cell markers, namely tight junction proteins (occludin and claudin-5 and influx and efflux transporters (Glut-1 and P-glycoprotein, the latter supporting evidence for functional effectiveness of the fetal blood-brain barrier. According to the well-known roles of astroglia cells on microvessel growth and differentiation, the early composition of astroglia/endothelial cell relationships was analysed by detecting the appropriate astroglia, endothelial, and pericyte markers. GFAP, chemokine CXCL12, and connexin 43 (Cx43 were utilized as markers of radial glia cells, CD105 (endoglin as a marker of angiogenically activated endothelial cells, and proteoglycan NG2 as a marker of immature pericytes. Immunolabeling for CXCL12 showed the highest level of the ligand in radial glial fibres in contact with the growing cortex microvessels. These specialized contacts, recognizable on both perforating radial vessels and growing collaterals, appeared as CXCL12-reactive en passant, symmetrical and asymmetrical vessel-specific RG fibre swellings. At the highest confocal resolution, these RG varicosities showed a CXCL12-reactive dot-like content whose microvesicular nature was confirmed by ultrastructural observations. A further analysis of radial glial varicosities reveals colocalization of CXCL12 with connexin Cx43, which is possibly implicated in vessel-specific chemokine signalling.

  12. Efeitos da facilitação neuromuscular proprioceptiva na estabilidade postural e risco de quedas em pacientes com sequela de acidente vascular encefálico: estudo piloto Efectos de la facilitación neuromuscular propioceptiva en la estabilidad postural y riesgo de caídas en pacientes con secuela de accidente vascular encefálico: estudio piloto Effects of proprioceptive neuromuscular facilitation in postural stability and risk of falls in patients with sequelae of stroke: pilot study

    Directory of Open Access Journals (Sweden)

    Natália Noman de Lacerda

    2013-03-01

    Full Text Available O controle do tronco é uma habilidade motora básica necessária para executar diversas tarefas funcionais, e é deficiente em pacientes que sofreram acidente vascular encefálico (AVE. Objetivo: Avaliar o efeito do método facilitação neuromuscular proprioceptiva (PNF na estabilidade postural e risco de quedas em pacientes com sequela de AVE. Metodologia: Foi realizado estudo de intervenção que consistiu em treinamento da estabilidade postural por meio de um protocolo fixo constituído por 5 exercícios utilizando o método PNF, onde foram realizados 10 atendimentos com frequência de três vezes por semana e duração em média de 45 minutos, e para a avaliação dos desfechos, utilizou-se a escala de equilíbrio de Berg (EEB. Resultados: Foram atendidos 12 homens com hemiparesia à esquerda e no mínimo seis meses de evolução e observou-se diferença altamente significativa entre os valores pré e pós teste por meio da EEB (pEl control del tronco es una habilidad motora básica necesaria para realizar diversas tareas funcionales y es deficiente en los pacientes que han sufrido Accidente Vascular Encefálico (AVE. Objetivo: Evaluar el efecto del método de Facilitación Neuromuscular Propioceptiva (PNF en la estabilidad postural y riesgo de caídas en pacientes con secuela de Accidente Vascular Encefálico (AVE. Metodología: Se realizó un estudio de intervención que consistió en entrenamiento de la estabilidad postural por medio de un protocolo fijo compuesto por cinco ejercicios utilizando el método PNF, donde fueron realizadas 10 sesiones, con frecuencia de tres veces por semana y duración media de 45 minutos. Para la evaluación de los resultados, se utilizó la escala de equilibrio de Berg (EEB. Resultados: Fueron atendidos 12 hombres con hemiparesia izquierda con un mínimo de seis meses de evolución y se observó diferencia altamente significativa entre los valores pre y post test por medio de la EEB (pThe trunk control is

  13. Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat

    DEFF Research Database (Denmark)

    Henriksson, Marie; Stenman, Emelie; Vikman, Petter;

    2007-01-01

    BACKGROUND: Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ipsilateral middle cerebral artery...... with Ro-32-0432 in ischemic stroke decreases the ischemic infarction area, neurological symptoms and associated endothelin B receptor upregulation. This provides a new perspective on possible mechanisms of actions of PKC inhibition in cerebral ischemia........ The present study aimed to examine the effect of the PKC inhibitor Ro-32-0432 on endothelin receptor upregulation, infarct volume and neurology outcome after middle cerebral artery occlusion in rat. RESULTS: At 24 hours after transient middle cerebral artery occlusion (MCAO), the contractile endothelin B...

  14. Hippocampal expression of synaptic structural proteins and phosphorylated cAMP response element-binding protein in a rat model of vascular dementia induced by chronic cerebral hypoperfusion

    Institute of Scientific and Technical Information of China (English)

    Hui Zhao; Zhiyong Li; Yali Wang; Qiuxia Zhang

    2012-01-01

    The present study established a rat model of vascular dementia induced by chronic cerebral hy-poperfusion through permanent ligation of bilateral common carotid arteries. At 60 days after mod-eling, escape latency and swimming path length during hidden-platform acquisition training in Morris water maze significantly increased in the model group. In addition, the number of accurate crossings over the original platform significantly decreased, hippocampal CA1 synaptophysin and growth-associated protein 43 expression significantly decreased, cAMP response element-binding protein expression remained unchanged, and phosphorylated cAMP response element-binding protein expression significantly decreased. Results suggested that abnormal expression of hippo-campal synaptic structural protein and cAMP response element-binding protein phosphorylation played a role in cognitive impairment following chronic cerebral hypoperfusion.

  15. Clinical value of multi-slice helical CT angiography in diagnosis of cerebral vascular diseases%MSCTA在脑血管性疾病诊断中的应用价值

    Institute of Scientific and Technical Information of China (English)

    宁殿秀; 李智勇; 王克礼

    2006-01-01

    Objective: To evaluate the clinical value of multi-slice helical CT angiography (MSCTA) in diagnosis of cerebral vascular diseases.Methods: 52 patients with cerebral vascular diseases were examined with GE Light Speed 4-slice and 16-slice helical CT.Pitch: 0.5-3,slice thickness: 0.625-1.25 mm,adult injection dosage: 90-100 mL,children injection dosage: 2 mL/kg,injection rate: 2.5-4.0 mL/s,delay time: 15-22 s.Intelligent track scan (Smart prep Rx) were adopted in parts of these cases.Three-dimensional cerebral vascular images were processed at ADW 3.1 and ADW 4.2 workstation.Results:MSCTA could clearly display spacious anatomic details of cerebral aneurysm,including its origin,size,neck width,and trend etc.MSCTA results of 19 cases were consistent with those of operations.The diameter of the smallest cerebral aneurysm shown in our research was about 3 mm.As a non-invasive examination,MSCTA could also be applied in post-operational evaluation of cerebral aneurysm by observing the location of silver clip and the distant vessels.Besides,MSCTA could be used to diagnose arteriovenous malformation and moyamoya disease.Of all the three-dimentional imaging methods,volume rendering (VR)is the best means to display the cerebral vascular diseases.Conclusion: As a non-invasive examination,MSCTA plays an important role in detection,pre-operational and post-operational evaluation of cerebral vascular diseases.

  16. Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat

    Directory of Open Access Journals (Sweden)

    Vikman Petter

    2007-01-01

    Full Text Available Abstract Background Protein kinase C (PKC is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ipsilateral middle cerebral artery. The present study aimed to examine the effect of the PKC inhibitor Ro-32-0432 on endothelin receptor upregulation, infarct volume and neurology outcome after middle cerebral artery occlusion in rat. Results At 24 hours after transient middle cerebral artery occlusion (MCAO, the contractile endothelin B receptor mediated response and the endothelin B receptor protein expression were upregulated in the ipsilateral but not the contralateral middle cerebral artery. In Ro-32-0432 treated rats, the upregulated endothelin receptor response was attenuated. Furthermore, Ro-32-0432 treatment decreased the ischemic brain damage significantly and improved neurological scores. Immunohistochemistry showed fainter staining of endothelin B receptor protein in the smooth muscle cells of the ipsilateral middle cerebral artery of Ro-32-0432 treated rats compared to control. Conclusion The results suggest that treatment with Ro-32-0432 in ischemic stroke decreases the ischemic infarction area, neurological symptoms and associated endothelin B receptor upregulation. This provides a new perspective on possible mechanisms of actions of PKC inhibition in cerebral ischemia.

  17. Acidente vascular encefálico como complicação da hipertensão arterial: quais são os fatores intervenientes? Accidente Vascular Encefálico como complicación de la hipertensión arterial: ¿cuáles son los factores que interfieren? Stroke as complication of arterial hypertension: which are the intervenient factors?

    Directory of Open Access Journals (Sweden)

    Larissa Bento de Araújo Mendonça

    2012-06-01

    Full Text Available O objetivo foi identificar os fatores intervenientes na adesão ao tratamento anti-hipertensivo que contribuíram para surgimento do acidente vascular encefálico (AVE. Estudo descritivo realizado em uma Unidade de AVE de um hospital público. A amostra constituiuse de 75 pacientes com diagnóstico de Hipertensão Arterial Sistêmica acometidos por um AVE. A coleta de dados aconteceu em março e abril de 2010. Estudo aprovado pelo Comitê de Ética e Pesquisa sob parecer nº 110302/10. Os fatores intervenientes na adesão do paciente ao tratamento anti-hipertensivo foram: sexo masculino (61,4%, idade >60 anos (48%, antecedentes familiares para HAS (68%, baixa escolaridade (72%, renda familiar até um salário mínimo (52% e presença de efeitos colaterais (22,6%. Talvez a experiência de um AVE seja um fator determinante para a maior adesão do paciente ao tratamento antihipertensivo. É necessário que os enfermeiros realizem acompanhamento ao hipertenso periodicamente, informando-o acerca da doença e do tratamento, visando evitar complicações.El objetivo fue identificar los factores que intervienen en la adherencia al tratamiento antihipertensivo que contribuyeron a la aparición del accidente vascular encefálico (ACV. Estudio descriptivo en una unidad de ACV de un hospital público. La muestra fue constituida por 75 pacientes diagnosticados con Hipertensión Arterial Sistémica afectados por el ACV. La recolección de datos ocurrió entre marzo y abril de 2010. Estudio aprobado por el Comité de Ética e Investigación bajo parecer nº 110302/10. Los factores que intervienen en la adhesión del paciente al tratamiento antihipertensivo fueron: sexo masculino (61,4%, edad > 60 años (48%, antecedentes familiares de hipertensión arterial (68%, baja escolaridad (72%, renta familiar hasta un sueldo mínimo (52% y presencia de efectos colaterales (22,6%. Tal vez la experiencia de un ACV sea un factor determinante en la mayor adherencia del

  18. Epidemiologia dos acidentes cerebrovasculares em Joinville, Brasil: estudo institucional Epidemiology of cerebrovascular disease in Joinville, Brazil: an institutional study

    Directory of Open Access Journals (Sweden)

    Norberto L. Cabral

    1997-09-01

    Full Text Available A carência de dados epidemiológicos e a impressão prévia de elevada incidência de acidente vascular cerebral (AVC no Brasil criou o estímulo para estudo institucional prospectivo em Joinville. No período de 1-março-1995 a 1-março-1996, avaliamos o primeiro episódio e episódios recorrentes em AVC, incidência, mortalidade, taxa de fatalidade-caso em 30 dias (letalidade, freqüência de fatores de risco, tempo para admissão hospitalar e distribuição dos infartos cerebrais por subtipos patológicos. Registramos 429 pacientes no período, 320 destes com primeiro episódio. Tomografia de crânio foi realizada em 98% dos casos. A taxa de incidência anual ajustada por idade em primeiro episódio de AVC foi de 156/100000. A distribuição por diagnóstico foi: 73,4% para infarto cerebral, 18.4% para hemorragia cerebral e 7,5% para hemorragia subaracnóide. A taxa de mortalidade anual padronizada foi 25/100000. A letalidade foi 26%. Hipertensão, AVC prévio e diabetes foram os fatores de risco mais freqüentes. Somente 25% dos pacientes chegaram ao hospital nas primeiras três horas iniciais. Concluímos que a taxa de incidência em primeiro episódio de AVC em pacientes institucionalizados em Joinville, Brasil, é elevada. A taxa de mortalidade e letalidade são similares as de outras populações.The paucity of epidemiologic data, and the previous impression of high incidence of cerebrovascular disease in Brazil, made us elaborate a prospective institutional study in Joinville, Brazil, with the objective of identifying first and recurrent episodes in stroke. This study occurred from March 1995 to March 1996. We evaluated during the first episode of stroke: incidence, mortality and fatality-case rate (in 30 days letality, frequency of risk factor, time in hospital and distribution of cerebral infarcts by pathological subtypes. In this period, 429 patients with stroke were registered, 320 with the first episode. 98% of all the patients

  19. ACIDENTE VASCULAR ENCEFÁLICO: PERFIL DE INDICADORES DE RISCO

    Directory of Open Access Journals (Sweden)

    Rafaella Pessoa Moreira

    2010-01-01

    Full Text Available El conocimiento de los indicadores de riesgo auxilia en la construcción de estrategias más eficaces de intervención en las personas con accidente cerebrovascular (ACE El objetivo del estudio fue identificar los indicadores de riesgo en los clientes que sobrevivieron a esta enfermedad. Estudio transversal, realizado con 121 clientes que frecuentaban unidades de rehabilitación en Fortaleza. Datos recogidos de noviembre del 2007 a marzo del 2008, a través de entrevista. El promedio de edad fue 61,6 años (± 12,4. La mayoría era del sexo masculino (52,9%. Los clientes presentaron en promedio 1,4 (±1,0 episodios de ACV. De los indicadores de riesgo, el de mayor presencia fue la hipertensión arterial (85,1%, seguido por el sedentarismo (58,7%, y dislipidemias (29,8%. Se concluye que la hipertensión arterial fue el indicador de riesgo más percibido y que las medidas de control de esa enfermedad deben ser implementadas para reducir el riesgo de nuevos ACV.

  20. Relationship between walking performance and types of community-based activities in people with stroke: an observational study Relação entre desempenho da marcha e tipos de atividades na comunidade após acidente vascular encefálico

    Directory of Open Access Journals (Sweden)

    Matar Alzahrani

    2011-02-01

    Full Text Available OBJECTIVES: To examine the relationship between clinical walking performance and amount and type of community activity in people after stroke. METHODS: A cross-sectional observational study of 14 people with stroke living in Sydney and able to walk was carried out. Demographics (such as age, gender, side of stroke, time since stroke, presence of spouse and aspects of walking performance (such as speed, capacity, automaticity, and stairs ability were measured. People with stroke were observed for at least five hours while they carried out activities in the community. These activities were then categorized into four types: domestic intrinsic, domestic extrinsic, leisure without contact, and leisure with contact activity. RESULTS: No relationship was found between walking performance and the amount of community activity. There was no relationship between walking performance and total time spent on domestic intrinsic activity. Walking speed and stairs ability were significantly correlated with leisure with contact activity (r=0.56, p=0.04, and r=0.57, p=0.03 respectively and inversely correlated with leisure without contact (r=-0.72, pOBJETIVOS: Examinar a relação entre o desempenho da marcha e a quantidade e tipo de atividades na comunidade em indivíduos após acidente vascular encefálico (AVE. MÉTODOS: Realizou-se um estudo observacional transversal em 14 indivíduos com AVE, aptos a deambular, residentes em Sydney. Resultados demográficos (como idade, gênero, lado hemiparético, tempo desde o AVE, estado civil e aspectos de desempenho da marcha (como velocidade, resistência, automaticidade e habilidade de usar escadas foram avaliados. Os indivíduos foram observados por pelo menos cinco horas durante suas atividades na comunidade. Essas atividades foram então categorizadas em quatro tipos: intrínseco-doméstica, extrínseco-doméstica, atividade de lazer com contato e atividade de lazer sem contato. RESULTADOS: Nenhuma relação foi

  1. Propriedades psicométricas da versão brasileira da escala de qualidade de vida específica para acidente vascular encefálico: aplicação do modelo Rasch Psychometric properties of the Brazilian version of the Stroke Specific Quality of Life Scale: application of the Rasch model

    Directory of Open Access Journals (Sweden)

    RCM Lima

    2008-04-01

    Full Text Available CONTEXTUALIZAÇÃO: O acidente vascular encefálico (AVE produz déficits importantes na qualidade de vida (QV dos indivíduos. Medidas específicas de QV são necessárias para compreender e quantificar o impacto dessa patologia. OBJETIVO: O objetivo desse estudo foi adaptar transculturalmente o Stroke Specific Quality of Life Scale (SSQOL para o Português (Brasil e avaliar suas propriedades psicométricas. MATERIAIS E MÉTODOS: O SSQOL foi traduzido e adaptado seguindo instruções padronizadas e submetido a exame de confiabilidade teste-reteste (10 hemiplégicos. As propriedades psicométricas foram investigadas pela análise Rasch em 50 hemiplégicos. RESULTADOS: Foram detectados coeficientes de confiabilidade de 0,92 para itens e indivíduos. O índice de separação dos hemiplégicos foi 3,34 e dos itens, 3,36, ou seja, os itens separaram as pessoas em pelo menos três níveis de QV e em três níveis de QV - baixa, média e alta. Dos 49 itens, quatro não se enquadram no modelo, o que compromete a validade de constructo do instrumento, embora o padrão errático dos itens se justifique na amostra examinada. CONCLUSÕES: O instrumento mostrou-se clinicamente útil na população avaliada. Novos estudos em populações com outras características já estão em andamento.BACKGROUND: Stroke results in important deficits, which reduce individuals’ quality of life (QOL. Specific QOL measurements are necessary to understand and quantify the impact of this pathological condition. OBJECTIVE: The aim of this study was to make a transcultural adaptation of the Stroke Specific Quality of Life Scale (SSQOL into Brazilian Portuguese and to assess its psychometric properties. METHODS: The SSQOL was translated and adapted in accordance with standardized procedures and was subjected to test-retest reliability analysis with 10 hemiplegic subjects. The psychometric properties were investigated using Rasch analysis on 50 hemiplegics. RESULTS: Reliability

  2. Estimulação elétrica funcional na subluxação crônica do ombro após acidente vascular encefálico: relato de casos Functional electrical stimulation for shoulder subluxation after chronic stroke: a case report

    Directory of Open Access Journals (Sweden)

    Juliana Barbosa Corrêa

    2009-03-01

    Full Text Available A subluxação do ombro é comum em indivíduos que sofreram acidente vascular encefálico (AVE, podendo gerar dor, lesões do plexo braquial, capsulite adesiva e lesões nos músculos da bainha rotatória, implicando atraso da reabilitação e interferência na qualidade de vida. O objetivo deste estudo foi verificar os efeitos da estimulação elétrica funcional (EEF na subluxação crônica do ombro em pacientes hemiplégicos que sofreram AVE. Foram avaliados três pacientes tendo tido AVE há mais de um ano com subluxação do ombro confirmada por exame de raios X. Foram analisados, antes e após o tratamento, o grau de subluxação e amplitude de movimento (ADM do ombro, função sensório-motora pela escala de Fugl-Meyer e dor em repouso e à movimentação passiva por meio de escala visual analógica. Todos os pacientes foram submetidos a tratamento com fisioterapia convencional e EEF no membro hemiplégico por dez sessões. A análise dos resultados mostrou melhora em relação às medidas iniciais da ADM, da avaliação sensório-motora, dor e subluxação do ombro após o uso da EEF. Concluiu-se que a EEF, asociada à fisioterapia convencional, mostrou-se eficaz em produzir diminuição da subluxação, aumento da função do membro superior e agir no alívio da dor em pacientes com subluxação do ombro pós-AVE.Shoulder subluxation is a common complication among stroke survivors; it may cause pain, brachial plexus injuries, adhesive capsulitis and rotator cuff muscle injuries, leading to rehabilitation delay and interference in patients' quality of life. The purpose of this study was to assess the effects of functional electrical stimulation (FES in post-stroke hemiplegia shoulder subluxation. Three patients with over one year of stroke onset and shoulder subluxation confirmed by X ray were assessed prior to, and after FES treatment, as to: degree of shoulder subluxation and range of motion (ROM; sensory-motor function by the Fugl

  3. Elaboração de um manual ilustrado de exercícios domiciliares para pacientes com hemiparesia secundária ao acidente vascular encefálico (AVE Elaboration of an illustrated home exercise manual for stroke patients with hemiparesis

    Directory of Open Access Journals (Sweden)

    Adriana Maria Barsante Santos

    2012-03-01

    Full Text Available A realização de exercícios físicos para pacientes com sequelas motoras pós-acidente vascular encefálico (AVE é essencial para a recuperação funcional. Programas educacionais podem facilitar a repetição dos exercícios em casa e contribuir para o tratamento. Este trabalho teve como objetivo elaborar e aplicar um manual de exercícios domiciliares para pacientes com AVE. O estudo consistiu em duas etapas: na primeira foi elaborado um manual de exercícios domiciliares (piloto com fotos e textos simples para facilitar a compreensão. Foi realizada uma avaliação funcional de cada paciente e selecionados os exercícios mais adequados, que deveriam ser feitos em casa. Esse manual foi aplicado a 17 pacientes, 70% crônicos e 30% agudos. Após 15 dias, o paciente retornava e era solicitado que reproduzisse os exercícios e informasse o nível de compreensão das fotos e do texto do manual e se sentia dor ao realizá-los. As fotos e os exercícios referidos como difíceis foram revistos, e criada a versão teste que foi aplicada em outros 23 pacientes, dando origem à versão final do manual. A avaliação do manual piloto foi insatisfatória, sendo que apenas 56% referiram aprovação das fotos e 87% do texto. Após a reformulação, a compreensão das fotos e do texto alcançou valores acima de 98%. Foi possível obter um manual ilustrado de exercícios domiciliares, de fácil aplicação e compreensão, específico e individualizado, para pacientes com AVE e adaptável aos diferentes quadros motores.The practice of exercises for patients with motor sequels post-stroke is essential for the functional recovery. Educational programs can facilitate the repetition of the exercises at home and contribute to the treatment. The objective of this study was to elaborate a home exercise manual for stroke patients. The study consisted of two stages: in the first one, a home exercise manual was made (pilot with pictures and simple text to facilitate

  4. Use of an optical technique to evaluate the cerebral vascular effects of alcohol (A): Effects on deoxyhemoglobin (DH) and levels of reduced cytochrome oxidase (rCO)

    Energy Technology Data Exchange (ETDEWEB)

    Barbour, R.L.; Gebiewold, A.; Altura, B.M. (Southern Univ. of New York, Brooklyn (United States))

    1992-02-26

    The dose-response effects of acute A infusion were studied to examine the suggestion that A can induce stroke-like events as a consequence of cerebral vasospasm. By employing a single sending and receiving fiber, an optical backscatter measurement was employed to monitor the levels in DH and rCO in a closed cranium preparation. Anesthetized rats were prepared by cannulating a branch of the internal carotid artery and subjected to either a bolus infusion (BI) or to a constant infusion (CI) of 5 or 10% A at various rates. Results showed that low BI doses of A typically produced a slight increase in the oxyhemoglobin signal indicating that vasodilation had probably occurred. Higher BI doses, however, produced a prompt and significant reduction in the hemoglobin signal with a rise in rCO suggesting a vasoconstrictor response leading to ischemia, followed by recovery within 3-5 min. CI of A produced a similar cerebral vascular response, in a dose-related manner, but of a more sustained nature. At 30-50% of the BI dose levels, a global blanching of the brain surface occurred; rCO levels increased by 50-90% with a corresponding decline in levels of oxyhemoglobin. Control experiments using identical volumes/flow rates of Ringers solution failed to produce any alterations in the optical spectrum. Overall, these data indicate that, depending on dose, (a) A can induce vasodilatory or vasoconstrictor effects in the intact brain; (b) the more pronounced effects involve vasospasm in the cortical microcirculation leading to global ischemia as determined by elevated levels of rCO and DH; (c) optical measurements permit direct noninvasive assessment of the cerebral vascular effects of substances of abuse.

  5. Epidemiologia e quadro clínico do acidente por cascavel sul-americana (Crotalus durissus Epidemiology and clinical features of South American rattlesnakes (Crotalus durissus envenomation

    Directory of Open Access Journals (Sweden)

    Miguel Tanús Jorge

    1992-08-01

    Full Text Available Foram estudados 249 casos de acidentes por cascavel sul-americana (Crotalus durissus atendidos no HVB-IB, São Paulo, Brasil, de 1974 a 1990. Os acidentes foram mais comuns no período da tarde, nos meses de janeiro a abril e de outubro a dezembro. Dentre cem serpentes classificadas quanto à subespécie 99 eram C. d. terrificus. Pertenciam ao sexo masculino 80,7% dos pacientes. Os membros inferiores e superiores foram picados em, respectivamente, 66,4% e 29,2% dos casos. As manifestações clínicas mais freqüentes foram dor (61,0% e edema (55,0% no local da picada, ptose palpebral (75,9%, escurecimento da urina atribuível à mioglobinúria (38,6% e mialgia (36,1%. Nove pacientes foram submetidos a diálise devido a insuficiência renal aguda (3,6%, três apresentavam insuficiência respiratória que motivou intubação e/ou traqueostomia e um apresentou acidente vascular cerebral isquêmico. A alteração da coagulação sanguínea ocorreu em 48,1% dos pacientes. Oito amostras de sangue colhidas horas após a picada mostraram leucocitose sendo 6 com desvio a esquerda e, nos dias subseqüentes, tendência à normalização do número de leucócitos e aparecimento de eosinofilia. Atividade sérica da creatinoquinase apresentou-se aumentada em 20 dentre 21 pacientes, sendo maior no final das primeiras 24 horas após a picada, chegando a 2.377 vezes o valor de referência. A letalidade foi de 0,8%.Under study were two hundred and forty nine cases of accidents caused by South American rattlesnakes (Crotalus durissus admitted to the Vital Brasil Hospital, São Paulo, Brasil, from 1974 to 1990. The accidents were more common in the afternoon, from January to April and from October to December. Ninety nine out of 100 snakes classified as subspecies were C. d. terrificus. Most of the patients were males (80.7%. The inferior and superior limbs were bitten in 66.4% and 29.2% of the cases, respectively. The more frequent clinical manifestations were

  6. iFlow in the auxiliary diagnosis of cerebral vascular disease%iFlow成像辅助诊断脑血管性病变

    Institute of Scientific and Technical Information of China (English)

    黄远亮; 周玉明; 童绥君; 傅建新; 王向东; 姜园

    2011-01-01

    目的 评估iFlow成像在脑血管性病变中的辅助诊断价值.方法对65例脑血管病变患者进行常规全脑2DDSA检查,对所采集的图像用iFlow软件编码,由低年资和高年资医师分别观察2D DSA图像及iFlow彩色编码血流图的血管解剖、病灶形态、大小、血流动力学情况,评估iFlow对脑血管病变是否具有辅助诊断价值.结果 iFlow成像能在一幅iFlow彩色编码血流图上完整显示脑血管DSA采集的动态序列所包含的病变信息,包括病灶的解剖形态、血流动力学变化及组织灌注情况,较2D DSA更加直观.低年资医师和高年资医师对iFlow辅助诊断价值认定的差异有统计学意义(x2=6.032,P=0.014).结论iFlow较单独2D DSA图像显示病变更全面,能对临床医师、尤其是低年资医师诊断和评估脑血管病变提供帮助.%Objective To evaluate the impact of iFlow in the auxiliary diagnosis of cerebral vascular diseases.Methods Totally 65 patients with cerebral vascular diseases underwent whole brain 2D DSA.Then the data were converted to color coded images with iFlow.The vascular anatomy,the shape and size of lesions,the blood dynamics on 2D DSA and iFlow images were evaluated by junior and senior physicians,who then reported whether iFlow images had supplementary diagnosis value.Results iFlow images displayed whole information of lesions more clearly than those of 2D DSA in brain vascular dynamic sequence,including vascular anatomy,hemodynamic changes and tissues perfusions.The evaluation of 2D DSA and iFlow images with junior and senior physicians had statistical difference (x2 =6.032,P=0.014).Conclusion Compared to single DSA,iFlow can facilitate the diagnosis and evaluation of cerebral vascular diseases,especially for junior physicians.

  7. Cerebral Arteriosclerosis

    Science.gov (United States)

    ... the brain can cause a hemorrhagic stroke. Both types of stroke can be fatal. Cerebral arteriosclerosis is also related to a condition known as vascular dementia, in which small, symptom-free strokes cause cumulative damage and death to neurons (nerve cells) in the brain. Personality changes in ...

  8. Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries

    DEFF Research Database (Denmark)

    Sandhu, Hardip; Ansar, Saema; Edvinsson, Lars

    2010-01-01

    on translational level and increased respective contractions. The prostanoid TP receptor mediated contraction curve was left-wards shifted by organ culture. Organ culture was associated with elevated pERK1/2 in the vascular smooth muscle cells: the MEK1/2 inhibitor U0126 attenuated the endothelin ET(B) receptor......Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase (ERK) specific inhibitors will attenuate the G......-protein coupled receptor expression following organ culture. Rat cerebral arteries were incubated 48h in the presence of MEK/ERK specific inhibitors U0126, PD98059, SL327, or AG126 for different time periods. Contractile responses by activation of endothelin receptor type A and type B, serotonin receptor 5-HT(1B...

  9. Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein

    OpenAIRE

    Rangel, Alejandra; Race, Brent; Klingeborn, Mikael; Striebel, James; Chesebro, Bruce

    2013-01-01

    Background In some prion diseases, misfolded aggregated protease-resistant prion protein (PrPres) is found in brain as amyloid, which can cause cerebral amyloid angiopathy. Small diffusible precursors of PrPres amyloid might flow with brain interstitial fluid (ISF), possibly accounting for the perivascular and intravascular distribution of PrPres amyloid. We previously reported that PrPres amyloid in scrapie-infected transgenic mice appeared to delay clearance of microinjected brain ISF trace...

  10. Exercise Training Could Improve Age-Related Changes in Cerebral Blood Flow and Capillary Vascularity through the Upregulation of VEGF and eNOS

    Directory of Open Access Journals (Sweden)

    Sheepsumon Viboolvorakul

    2014-01-01

    Full Text Available This study aimed to investigate the effect of exercise training on age-induced microvascular alterations in the brain. Additionally, the association with the protein levels of vascular endothelial growth factor (VEGF and endothelial nitric oxide synthase (eNOS was also assessed. Male Wistar rats were divided into four groups: sedentary-young (SE-Young, n=5, sedentary aged (SE-Aged, n=8, immersed-aged (IM-Aged, n=5, and exercise trained-aged (ET-Aged, 60 minutes/day and 5 days/week for 8 weeks, n=8 rats. The MAPs of all aged groups, SE-Aged, IM-Aged, and ET-Aged, were significantly higher than that of the SE-Young group. The regional cerebral blood flow (rCBF in the SE-Aged and IM-Aged was significantly decreased as compared to SE-Young groups. However, rCBF of ET-Aged group was significantly higher than that in the IM-Aged group (P<0.05. Moreover, the percentage of capillary vascularity (%CV and the levels of VEGF and eNOS in the ET-Aged group were significantly increased compared to the IM-Aged group (P<0.05. These results imply that exercise training could improve age-induced microvascular changes and hypoperfusion closely associated with the upregulation of VEGF and eNOS.

  11. 64层螺旋CT脑灌注成像联合CT血管造影评价颅内外血管搭桥术后疗效%Assessment of cerebral internal and external vascular bypass graft in patients with single middle cerebral artery stenosis or occlusion by combining 64-row CT cerebral perfusion with angiography

    Institute of Scientific and Technical Information of China (English)

    陈天金; 朱栓庄; 温有信; 王耀彬; 韩向东; 白莹; 于旋

    2012-01-01

    Objective To assess the curative effect of cerebral internal and external vascular bypass graft in patients with sin -gle middle cerebral artery (MCA) stenosis or occlusion by combining 64 -row CT cerebral perfusion (CTP) with angiography ( CTA ). Methods Patients with middle cerebral artery stenosis or occlusion were recruited and underwent superficial temporal artery and mid -die cerebral artery(STA -MCA) bypass graft between March 2009 and Mar 2011. CTP and CTA examinations were performed in all patients before and after operation. The cerebral perfusion parameters were analyzed quantitatively and qualitatively . The origin, travel and anastomotic stoma of bypass grafts were evaluated by reconstructed CTA images . Results 46 patients were found with severe MCA stenosis or occlusion. The time to peak (TTP) and relative mean transit time (rMTT) images before therapy displayed the existence of perfusion delay. The relative cerebral blood flow (rCBF) and relative cerebral blood volume (rCRV) images did not change significantly. The decrease of TTP and rMTT after therapy was of statistical significance ( P 0.05). In reconstructed CTA images , 82 bridge vessels were well displayed, including double bridges in 39 patients. The accuracy of CTA examination was 96.5%. All the bypass grafts were well shown and the anastomotic stomas were unobstructed. Conclusions It is feasible to evaluate the curative effects of cerebral internal and ex — ternal vascular bypass graft by combining CTP images of cerebral perfusion after therapy with CTA images of cerebral internal and exter -nal bypass grafts.%目的 探讨64层螺旋CT脑灌注成像(CT perfusion,CTP)联合CT血管造影(CT angiography,CTA)评价单侧大脑中动脉(middle cerebral artery,MCA)重度狭窄(闭塞)颅内外血管搭桥术后疗效的可行性.方法 46例拟行颅内外血管搭桥术患者,术前、后均行CTP及CTA检查.计算脑灌注参数图,对治疗前后脑灌注参数进行定量和定性对

  12. Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer's type and vascular dementia with deep white matter changes

    International Nuclear Information System (INIS)

    Regional cerebral blood flow (rCBF), cerebral metabolic rate of oxygen (rCMRO2), oxygen extraction fraction (rOEF), and cerebral blood volume (rCBV) were investigated using positron emission tomography (PET) in 16 patients with senile dementia of Alzheimer's type (SDAT), and compared with those of 6 nondemented and 3 demented patients with deep white matter high signal (DWMH) on T2-weighted MRI and 6 controls. rCBF, rCMRO2 and rCBV were determined using C15O2, 15O2 and C15O, respectively. rCBF and CMRO2 were significantly decreased in the frontal, parietal and temporal cortex (P 2 was significantly reduced in only the frontal and temporal cortex of demented patients (P < 0.05). rOEF was significantly increased in the parietal cortex of patients with SDAT and in the white matter of patients with SDAT or DWMH (P < 0.05), and the increase in the frontal white matter significantly paralleled the progression of dementia in patients with SDAT (P < 0.05). rCBV was significantly decreased in the parietal and temporal cortex of patients with SDAT (P < 0.05), but not in any areas of those with DWMH. (orig.)

  13. Regional cerebral blood flow before and after vascular surgery in patients with transient ischemic attacks with 133-xenon inhalation tomography

    DEFF Research Database (Denmark)

    Vorstrup, S; Hemmingsen, Ralf; Lindewald, H;

    1982-01-01

    with no abnormality on the CT-scan. The abnormal blood flow pattern was found to be unchanged after clinically successful reconstructive vascular surgery. This suggests the presence of irreversible ischemic tissue damage without gross emollition (incomplete infarction). It is concluded, that TIAs are often harmful...

  14. Logistic regression analysis on risk factors for vascular dementia following cerebral infarction in 403 patients from Chongqing City Hospital and family follow-up studies

    Institute of Scientific and Technical Information of China (English)

    Hong Yang; Jingcheng Li; Huadong Zhou

    2007-01-01

    BACKGROUND: Studies have demonstrated that the risk factors of vascular dementia following stroke are greatly different in region, race and other aspects.OBJECTIVE: To analyze the conditions and incidental risk factors of vascular dementia in patients with acute cerebral infarction from Chongqing City. DESIGN: Case analysis.SETTING: Department of Neurology, Daping Hospital, Third Military Medical University of Chinese PLA. PARTICIPANTS: Altogether 546 inpatients with acute ischemic stroke admitted to Department of Neurology, Daping Hospital, Third Military Medical University of Chinese PLA between May 1999 and December 2002 were involved in this study. The involved patients, including 295 males and 251 females, aged 55 - 94 years, dwelled in Chongqing over 5 years. They were admitted to hospital within 48 hours of attack of acute ischemic stroke, and survived for over 3 months. Informed consents were obtained from all the involved subjects.METHODS: ①Following the same standard, cognitive and social function evaluations were conducted by one physician on admission and 3 months after admission. Unified questionnaire, consisting of general characteristics, vascular risk factors, stroke characteristics, neurological physical sign, and other 28 factors of involved subjects, was used in all the patients. According to the investigation results, the patients were assigned into 2 groups: dementia group and non-dementia group. ②Ischemic stroke was diagnosed according to acute ischemic brain disorder>24 hours and CT or MRI imageology.③Neurophysiological examination was conducted in all the patients at 7 to 10 days after stroke (score was two SD less than or equaled to normal level was considered as abnormal).④Diagnosis and statistics of dementia were carried out with Mini-Mental State Examination and The Diagnostic and Statistical Manual of Mental Disorders-IV (published by American Psychiatric Association) on admission and 3 months after admission. Neurologic

  15. Burden and modifications in life from the perspective of caregivers for patients after stroke Sobrecarga y modificaciones de vida en la perspectiva de los cuidadores de pacientes con accidente vascular cerebral Sobrecarga e modificações de vida na perspectiva dos cuidadores de pacientes com acidente vascular cerebral

    OpenAIRE

    Huana Carolina Cândido Morais; Arethusa Morais de Gouveia Soares; Ana Railka de Souza Oliveira; Carolina Maria de Lima Carvalho; Maria Josefina da Silva; Thelma Leite de Araujo

    2012-01-01

    OBJECTIVE: to analyze the impact that caring has on a member of the family caring for a patient after a cerebrovascular accident, correlating life modifications and mental suffering with the perceived burden. METHOD: a cross-sectional, quantitative study, undertaken in January-April 2010 in Fortaleza, Ceará, Brazil. RESULT: 61 individuals were investigated, monitored by three hospitals' Home Care Program. Data collection was through interviews for identifying life changes, and through the app...

  16. Cerebral vascular autoregulation and CO2 reactivity following onset of the delayed postischemic hypoperfusion state in dogs.

    Science.gov (United States)

    Christopherson, T J; Milde, J H; Michenfelder, J D

    1993-03-01

    A small number of animal studies have suggested that during the delayed postischemic hypoperfusion state, CO2 reactivity of the cerebral vasculature is lost whereas autoregulation is retained. These findings, however, are inconsistent with the bulk of experimental evidence which demonstrates that CO2 reactivity is more robust and may be retained in pathologic circumstances which abolish autoregulation. These opposing viewpoints were therefore further evaluated in 18 dogs in which complete global ischemia was induced by cerebrospinal fluid (CSF) compression for periods of 12 (n = 12) and 18 (n = 6) min. Following 45 min of reperfusion and with onset of the delayed postischemic hypoperfusion state, autoregulation and CO2 reactivity were evaluated using a continuous measurement of CBF (by sagittal sinus outflow). CO2 reactivity was tested over a PaCO2 range of 20 to 60 mm Hg; autoregulation was tested over a blood pressure range of 60 to 140 mm Hg. Results demonstrated that after both 12 and 18 min of complete global ischemia, autoregulation and CO2 reactivity of the cerebral vasculature were both present, but attenuated. In the case of CO2 reactivity, the slope of the CBF response was decreased approximately 75%. In the case of autoregulation, the response in some dogs was incomplete as compared with their preischemic response. PMID:8436617

  17. Experimental stereotactic gamma knife radiosurgery. Vascular contractility studies of the rat middle cerebral artery after chronic survival.

    Science.gov (United States)

    Major, Otto; Szeifert, György Tamás; Radatz, Matthias W R; Walton, Lee; Kemeny, Andras Armand

    2002-03-01

    In vitro isometric small vessel myograph experiments and pathological investigations were performed on rat middle cerebral arteries. Thirty-four animals provided 68 normal vessels, six further rats had the endothelial layer mechanically removed from their 12 arteries. Eighteen animals received gamma knife irradiation to the middle cerebral arteries. Fifteen of these received 50 Gray, and three 25 Gray dose to the 50% isodose and the contralateral vessels offered 20 Gray and 15 Gray irradiated specimens. Survival times varied from 12 weeks to 18 months. In the acute stage, abolition of potassium-induced relaxation occurred as early as 24 h after irradiation whilst in one year this reaction seemed to recover and remained active to 18 months. The contraction response to prostaglandin F2 alpha was diminished at six weeks in the 50 Gray-irradiated vessels. However, from one year further reduction was seen and by 18 months this response was totally abolished. We demonstrated reduction of contractile capability of the irradiated normal vessels while the vessels remained patent. When using low irradiation dose there were no pathological changes even at 18 months, but marked physiological changes could be demonstrated. Different vessel wall functions appear to have different radiosensitivity, time course and capability for regeneration.

  18. Anesthesia Management of Patients with Cerebral Vascular Disease%脑血管病患神经介入治疗的麻醉管理

    Institute of Scientific and Technical Information of China (English)

    胥亮

    2015-01-01

    Objective In order to further explore the anesthetic management of patients with cerebral vascular disease in the treatment of neurological intervention. Methods According to the clinical data of 422 patients with cerebral vascular disease treated by interventional therapy in our hospital from March 2013 to March 2015, all patients were divided into management group (optimal anesthetic use and management method) and control group (211 patients). Results Compared with the two groups of patients with operation time, recovery time, the total effective rate of treatment, blood pressure recov-ery, anti hypertension, pain, blood pressure control effect and other clinical indicators, the management group were better than the control group, the results showed statistically significant difference (P<0.05). Conclusion The treatment of cerebral vascular disease with good anesthetic management strategy can not only play an ideal role in the treatment of patients, but also to ensure the operation of patients, reduce the use of anesthetic drugs in the process of adverse effects, improve the use of medical workers in the Department of Neurosurgery consciousness, should be the focus of clinical promotion.%目的:进一步探究脑血管病患者神经介入治疗的麻醉管理方法。方法根据该院2013年3月—2015年3月所收治的422例脑血管疾病行神经介入治疗病患的临床治疗资料,采用随机分组方式将全部患者分为管理组(优化麻醉剂使用和管理方法)和对照组(常规麻醉剂使用和管理方法),每组患者均为211人,对比两组患者治疗效果、麻醉解除时间等临床指标。结论对比两组患者手术时间、苏醒时间、治疗总有效以及血压回升平稳度、反跳性高血压、阵痛效果、血压控制效果等临床指标,管理组均优于对照组其对比结果,差异有统计学意义(P<0.05)。结果对于脑血管疾病行神经介入治疗病患良好的麻醉管

  19. Sleep Apnea, Sleep Duration and Brain MRI Markers of Cerebral Vascular Disease and Alzheimer's Disease: The Atherosclerosis Risk in Communities Study (ARIC.

    Directory of Open Access Journals (Sweden)

    Pamela L Lutsey

    Full Text Available A growing body of literature has suggested that obstructive sleep apnea (OSA and habitual short sleep duration are linked to poor cognitive function. Neuroimaging studies may provide insight into this relation.We tested the hypotheses that OSA and habitual short sleep duration, measured at ages 54-73 years, would be associated with adverse brain morphology at ages 67-89 years.Included in this analysis are 312 ARIC study participants who underwent in-home overnight polysomnography in 1996-1998 and brain MRI scans about 15 years later (2012-2013. Sleep apnea was quantified by the apnea-hypopnea index and categorized as moderate/severe (≥15.0 events/hour, mild (5.0-14.9 events/hour, or normal (<5.0 events/hour. Habitual sleep duration was categorized, in hours, as <7, 7 to <8, ≥8. MRI outcomes included number of infarcts (total, subcortical, and cortical and white matter hyperintensity (WMH and Alzheimer's disease signature region volumes. Multivariable adjusted logistic and linear regression models were used. All models incorporated inverse probability weighting, to adjust for potential selection bias.At the time of the sleep study participants were 61.7 (SD: 5.0 years old and 54% female; 19% had moderate/severe sleep apnea. MRI imaging took place 14.8 (SD: 1.0 years later, when participants were 76.5 (SD: 5.2 years old. In multivariable models which accounted for body mass index, neither OSA nor abnormal sleep duration were statistically significantly associated with odds of cerebral infarcts, WMH brain volumes or regional brain volumes.In this community-based sample, mid-life OSA and habitually short sleep duration were not associated with later-life cerebral markers of vascular dementia and Alzheimer's disease. However, selection bias may have influenced our results and the modest sample size led to relatively imprecise associations.

  20. Regional cerebral blood flow levels as measured by xenon-CT in vascular territorial low-density areas after subarachnoid hemorrhage are not always ischemic

    Energy Technology Data Exchange (ETDEWEB)

    Fainardi, E. [Arcispedale S. Anna, Neuroradiology Unit, Department of Neurosciences, Ferrara (Italy); Tagliaferri, M.F.; Compagnone, C.; Tanfani, A.; Cocciolo, F.; Targa, L.; Chieregato, A. [Ospedale M. Bufalini, Neurocritical Care Unit, Cesena (Italy); Battaglia, R.; Frattarelli, M. [Ospedale M. Bufalini, Neurosurgery Unit, Cesena (Italy); Pascarella, R. [Ospedale M. Bufalini, Neuroradiology Unit, Cesena (Italy)

    2006-09-15

    The aim of this study was to assess regional cerebral blood flow (rCBV) in areas of CT hypoattenuation appearing in the postoperative period in patients treated for aneurysmal subarachnoid hemorrhage (SAH) using xenon-enhanced CT scanning (Xe-CT). We analyzed 15 patients (5 male and 10 female; mean age 49.7{+-}12.1 years) with SAH on CT performed on admission to hospital and who showed a low-density area within a well-defined vascular territory on CT scans after clipping or coiling of a saccular aneurysm. All zones of hypoattenuation were larger than 1 cm{sup 2} and showed signs of a mass effect suggesting a subacute phase of evolution. Two aneurysms were detected in two patients. Aneurysms were located in the middle cerebral artery (n=7), in the anterior communicating artery (n=6), in the internal carotid artery (n=3), and in the posterior communicating artery (n=1). Treatments were surgical (n=8), endovascular (n=2) or both (n=1). A total of 36 Xe-CT studies were performed and rCBF values were measured in two different regions of interest (ROI): the low-density area, and an area of normal-appearing brain tissue located symmetrically in the contralateral hemisphere. rCBF levels were significantly lower in the low-density area than in the contralateral normal-appearing area (P<0.01). In the low-density areas, irreversible ischemia (CBF <10 ml/100 g per minute) was present in 11/36 lesions (30.6%), ischemic penumbra (CBF 10-20 ml/100 g per minute) and oligemia (CBF 20-34 ml/100 g per minute) in 8/36 lesions (22.2%), relative hyperemia (CBF 34-55 ml/100 g per minute) in 7/36 lesions (19.4%), and absolute hyperemia (CBF >55 ml/100 g per minute) in 2/36 lesions (5.6%). Our study confirmed that rCBF is reduced in new low-density lesions related to specific vascular territories. However, only about one-third of the lesions showed rCBF levels consistent with irreversible ischemia and in a relatively high proportion of lesions, rCBF levels indicated penumbral, oligemic and

  1. 血尿酸与脑血管病关系初探%A Study of the Relation between Serum Uric Acid and Cerebral Vascular Disease

    Institute of Scientific and Technical Information of China (English)

    谭来勋; 刘志超; 龙庆红

    2001-01-01

    To study the relation between the level of serum uric acid and cerebral vascular disease.Methods:The level of serum uric acid was investigated in 120 patients with acute cerebral vascular disease. Results:Patients with high uric acid level were more obese and likely to have a history of MI stroke and hypetrension(P<0.001).Furthermore, they had higher levels of serum creation,total cholesterol and total triglycerides and lower levels of LDL cholesterol,HDL cholesterol and serum glucose (P<0.001).High uric acid level was associated with the severity and outcome prognosis (P<0.05,0.005).Conclusion:Hyperuricemia is a strong predictor of stroke events and serum uric acid level is helpful in evaluating the severity and the outcome.%目的:探讨血尿酸与脑血管病的关系。方法:分析120例脑血管病患者临床资料及血尿酸含量。结果:高尿酸血症患者肥胖、有心肌梗塞史、脑卒中史、高血压病吏者较多(P<0.001),血肌酐、总胆固醇、总甘油三脂水平较高(P<0.001);而低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平、血糖水平较低(P<0.001);尿酸水平与病情、预后有关(P<0.01,0.005)。结论:高尿酸血症是脑血管危险因素;测定血尿酸含量有利于判断病情及评估预后。

  2. Usefulness of continuous suture using short-thread double-armed micro-suture for cerebral vascular anastomosis

    Directory of Open Access Journals (Sweden)

    Sei Haga

    2014-01-01

    Full Text Available Background: When microvascular anastomosis is performed in a deep, narrow operating field, securing space to throw knots is difficult. To simplify the procedure and avoid obstruction of the anastomosis, we use a continuous suturing with short-thread double-armed micro-suture. Methods: Sixty-four patients (38 cerebral revasculazation, 16 moyamoya disease, and 10 aneurysm surgery undergoing microvaucular anastomosis were included. During anastomosis, a continuous suture was placed with short-thread double-armed micro-suture. Results: During 64 microanastomosis procedures, 64 consecutive continuous sutures were performed with 1-year follow up. All patients showed patency of anastomosis with long-term follow up. Conclusions: This technique is especially useful for anastomosis in a deep, narrow surgical field, such as in superior cerebellar artery anastomosis.

  3. Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial claudin-5 and its modulation of cerebral vascular permeability.

    Science.gov (United States)

    Liao, Zhuangbin; Yang, Zhenguo; Piontek, Anna; Eichner, Miriam; Krause, Gerd; Li, Longxuan; Piontek, Joerg; Zhang, Jingjing

    2016-07-01

    The vertebrate blood-brain barrier (BBB) creates an obstacle for central nervous system-related drug delivery. Claudin-5 (Cldn5), expressed in large quantities in BBB, plays a vital role in restricting BBB permeability. The C-terminal domain of Clostridium perfringens enterotoxin (cCPE) has been verified as binding to a subset of claudins (Cldns). The Cldn5-binding cCPE194-319 variant cCPEY306W/S313H was applied in this study to investigate its ability to modulate the permeability of zebrafish larval BBB. In vitro results showed that cCPEY306W/S313H is able to bind specifically to Cldn5 in murine brain vascular endothelial (bEnd.3) cells, and is transported along with Cldn5 from the cell membrane to the cytoplasm, which in turn results in a reduction in transendothelial electrical resistance (TEER). Conversely, this effect can be reversed by removal of cCPEY306W/S313H. In an in vivo experiment, this study estimates the capability of cCPEY306W/S313H to modulate Cldn5 using a rhodamine B-Dextran dye diffusion assay in zebrafish larval BBB. The results show that cCPEY306W/S313H co-localized with Cldn5 in zebrafish cerebral vascular cells and modulated BBB permeability, resulting in dye leakage. Taken together, this study suggests that cCPEY306W/S313H has the capability - both in vitro and in vivo - to modulate BBB permeability temporarily by specific binding to Cldn5. PMID:27095710

  4. Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity.

    Science.gov (United States)

    Sun, Yawen; Cao, Wenwei; Ding, Weina; Wang, Yao; Han, Xu; Zhou, Yan; Xu, Qun; Zhang, Yong; Xu, Jianrong

    2016-01-01

    Abnormal reductions in cortical cerebral blood flow (CBF) have been identified in subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction in relation with the degree of cognitive impairment. CBF measured with three-dimensional (3D) Arterial Spin Labeling (ASL) perfusion magnetic resonance imaging (MRI) helps detect functional changes in subjects with SVCI. We aimed to compare CBF maps in subcortical ischemic vascular disease (SIVD) subjects with and without cognitive impairment and to detect the relationship of the regions of CBF reduction in the brain with the degree of cognitive impairment according to the z-score. A total of 53 subjects with SVCI and 23 matched SIVD subjects without cognitive impairment (controls), underwent a whole-brain 3D ASL MRI in the resting state. Regional CBF (rCBF) was compared voxel wise by using an analysis of variance design in a statistical parametric mapping program, with patient age and sex as covariates. Correlations were calculated between the rCBF value in the whole brain and the z-score in the 53 subjects with SVCI. Compared with the control subjects, SVCI group demonstrated diffuse decreased CBF in the brain. Significant positive correlations were determined in the rCBF values in the left hippocampus, left superior temporal pole gyrus, right superior frontal orbital lobe, right medial frontal orbital lobe, right middle temporal lobe, left thalamus and right insula with the z-scores in SVCI group. The noninvasively quantified resting CBF demonstrated altered CBF distributions in the SVCI brain. The deficit brain perfusions in the temporal and frontal lobe, hippocampus, thalamus and insula was related to the degree of cognitive impairment. Its relationship to cognition indicates the clinical relevance of this functional marker. Thus, our results provide further evidence for the mechanisms underlying the cognitive deficit in patients with SVCI. PMID:27630562

  5. Features of cerebral vascular reactivity in patients with different clinical course of a high degree of myopia

    Directory of Open Access Journals (Sweden)

    G. V. Shkrebets

    2014-07-01

    Full Text Available Purpose: to examine the state rate parameters of cerebral and ocular vessels in patients with glaucoma combined with myopia of high degree.Methods: the study involved 3 groups of patients aged 16-32 years: 1st — 30 patients (60 eyes — with a stationary myopia of 6.5 to 9.0 D and normal intraocular pressure (IOP; 2nd — 23 patients (46 eyes — with a high degree of progressive myopia and glaucoma with normalized intraocular pressure during instillation Azopt included 2 subgroups: subgroup A — 14 patients (28 eyes — with ischemic variant of glaucoma; subgroup B — 9 patients (18 eyes — with dyscirculatory variant of glaucoma; 3rd group (control — 10 somatically healthy individuals of similar age. Following a standard ophthalmic examination techniques, as well as color Doppler mapping of the main arteries of the brain and the eyeball on the unit Acuson 128 HR/10 (USA and hypocapnic (with O2 and hypercapnic (CO2 probe.Results: In subgroup 2A patients showed significant (p <0.05 decrease in Vs in the central retinal artery and short posterior cili- ary arteries respectively 38.0% and 32.8% and increase the resistance index (RI of vessels in 21.8% and 22.6%, increase Vs in the middle cerebral artery (MCA at 11.5% and RI by 11.8% compared to the patients the third and first groups, with а hypocapnic test Vs in the MCA decreased by 35.4%, and increased with hypercapnic test for 23.0%; of the subgroup B in central retinal vein to 33.9% and 19.6%, lower Vs and RI in the vertebral artery (VA by 20,0% and 9,1% respectively, with a hypercapnic test Vs in the MCA increased by 32.2%, and decreased during hypocapnic sample at 26.0%.Conclusion: the predominance of the ability of MCA to vasoconstriction combined with reduced blood flow in central retinal artery and short posterior ciliary arteries and cause ischemica variant of glaucoma, slowing blood flow in the vertebrobasilar basin combined with a reduction of venous outflow of the of the

  6. Malaria cerebral Cerebral malaria

    Directory of Open Access Journals (Sweden)

    Carlos Hugo Zapata Zapata

    2003-03-01

    Full Text Available La malaria Cerebral (MC es la complicación más frecuente de la malaria por P. falciparum; aproximadamente el 90% de las personas que la han padecido se recuperan completamente sin secuelas neurológicas. Aún no se conoce con claridad su patogénesis pero se han postulado cuatro hipótesis o mecanismos posibles: 1 citoadherencia y secuestro de glóbulos rojos parasitados en la microvasculatura cerebral; 2 formación de rosetas y aglutinación de glóbulos rojos parasitados; 3 producción de citoquinas y activación de segundos mensajeros y, 4 apertura de la barrera hematoencefálica. Sin embargo, queda un interrogante sin resolver aún: ¿qué proceso se lleva a cabo para que el parásito, desde el espacio microvascular, pueda interferir transitoriamente con la función cerebral? Recientemente se ha utilizado el precursor de la proteína b-Amiloide como un marcador de daño neuronal en MC; este precursor será de gran ayuda en futuras investigaciones realizadas en nuestro medio que aporten información para comprender la patogénesis de la MC. Is the most common complication of P. falciparum malaria; nearly 90% of people who have suffered CM can recover without neurological problems. Currently there are four hypotheses that explain pathogenesis of CM: cytoadherence and sequestering of parasitized red blood cells to cerebral capillaries; rosette formation and parasitized red blood cells agglutination; production of cytokines and activation of second messengers and opening of the blood-brain barrier. However the main question remains to be answered; how the host-parasite interaction in the vascular space interferes transiently with cerebral function? Recently, the beta amyloid precursor peptide has been employed as marker of neural injury in CM. It is expected that the beta amyloid precursor peptide will help to understand the pathogenesis of CM in complicated patients of endemic areas of Colombia.

  7. A New Computational Model for Neuro-Glio-Vascular Coupling: Astrocyte Activation Can Explain Cerebral Blood Flow Nonlinear Response to Interictal Events.

    Science.gov (United States)

    Blanchard, Solenna; Saillet, Sandrine; Ivanov, Anton; Benquet, Pascal; Bénar, Christian-George; Pélégrini-Issac, Mélanie; Benali, Habib; Wendling, Fabrice

    2016-01-01

    Developing a clear understanding of the relationship between cerebral blood flow (CBF) response and neuronal activity is of significant importance because CBF increase is essential to the health of neurons, for instance through oxygen supply. This relationship can be investigated by analyzing multimodal (fMRI, PET, laser Doppler…) recordings. However, the important number of intermediate (non-observable) variables involved in the underlying neurovascular coupling makes the discovery of mechanisms all the more difficult from the sole multimodal data. We present a new computational model developed at the population scale (voxel) with physiologically relevant but simple equations to facilitate the interpretation of regional multimodal recordings. This model links neuronal activity to regional CBF dynamics through neuro-glio-vascular coupling. This coupling involves a population of glial cells called astrocytes via their role in neurotransmitter (glutamate and GABA) recycling and their impact on neighboring vessels. In epilepsy, neuronal networks generate epileptiform discharges, leading to variations in astrocytic and CBF dynamics. In this study, we took advantage of these large variations in neuronal activity magnitude to test the capacity of our model to reproduce experimental data. We compared simulations from our model with isolated epileptiform events, which were obtained in vivo by simultaneous local field potential and laser Doppler recordings in rats after local bicuculline injection. We showed a predominant neuronal contribution for low level discharges and a significant astrocytic contribution for higher level discharges. Besides, neuronal contribution to CBF was linear while astrocytic contribution was nonlinear. Results thus indicate that the relationship between neuronal activity and CBF magnitudes can be nonlinear for isolated events and that this nonlinearity is due to astrocytic activity, highlighting the importance of astrocytes in the

  8. A New Computational Model for Neuro-Glio-Vascular Coupling: Astrocyte Activation Can Explain Cerebral Blood Flow Nonlinear Response to Interictal Events.

    Directory of Open Access Journals (Sweden)

    Solenna Blanchard

    Full Text Available Developing a clear understanding of the relationship between cerebral blood flow (CBF response and neuronal activity is of significant importance because CBF increase is essential to the health of neurons, for instance through oxygen supply. This relationship can be investigated by analyzing multimodal (fMRI, PET, laser Doppler… recordings. However, the important number of intermediate (non-observable variables involved in the underlying neurovascular coupling makes the discovery of mechanisms all the more difficult from the sole multimodal data. We present a new computational model developed at the population scale (voxel with physiologically relevant but simple equations to facilitate the interpretation of regional multimodal recordings. This model links neuronal activity to regional CBF dynamics through neuro-glio-vascular coupling. This coupling involves a population of glial cells called astrocytes via their role in neurotransmitter (glutamate and GABA recycling and their impact on neighboring vessels. In epilepsy, neuronal networks generate epileptiform discharges, leading to variations in astrocytic and CBF dynamics. In this study, we took advantage of these large variations in neuronal activity magnitude to test the capacity of our model to reproduce experimental data. We compared simulations from our model with isolated epileptiform events, which were obtained in vivo by simultaneous local field potential and laser Doppler recordings in rats after local bicuculline injection. We showed a predominant neuronal contribution for low level discharges and a significant astrocytic contribution for higher level discharges. Besides, neuronal contribution to CBF was linear while astrocytic contribution was nonlinear. Results thus indicate that the relationship between neuronal activity and CBF magnitudes can be nonlinear for isolated events and that this nonlinearity is due to astrocytic activity, highlighting the importance of astrocytes in

  9. Study on the change and relationship between plasma D-dimer and homocysteine levels in patients with acute cerebral vascular accident

    International Nuclear Information System (INIS)

    Objective: To study the clinical significance of the changes and the relationships between plasma D-dimer (D-D) and Homocysteine (Hcy) expression in patients with acute cerebral infarction and acute cerebral hemorrhage. Methods: Plasma D-D (with ELISA) and Hcy (with CLIA) levels were measured in 397 patients with cerebral infarction, 122 patients with cerebral hemorrhage and 30 controls.Results 1) The mean level of the plasma D-D and Hcy in patients with acute cerebral infarction was 5.20±0.92μg/L and 21.23±13.54 μmol/L respectively, which was significant higher than that in controls and patients with acute cerebral hemorrhage. 2) Higher expressing of D-D and Hcy was found in 101 (25.4%) and 140 (35.3%) cases of acute cerebral infarction patients. The data in acute cerebral hemorrhage group was 17 (13.9%) and 27 (22.1%) respectively. There was significant difference between two groups, P<0.01. 3) There was not correlations with the expression level of D-D and Hcy in patients with acute cerebral infarction and patients with acute cerebral hemorrhage. 4) The expressing level of the Plasma D-D in acute cerebral infarction patients was not significant difference in both age and sex. The expressing level of Hcy in male was higher than that in female. There was not significant difference in the expressing level of Hcy in different age. Conclusion: The levels of plasma D-D and Hcy in patients with acute cerebral infarction significantly in creased, but there were not correlations between the levels of the two parameters. (authors)

  10. Culpa da vítima: um modelo para perpetuar a impunidade nos acidentes do trabalho

    OpenAIRE

    Vilela Rodolfo Andrade Gouveia; Iguti Aparecida Mari; Almeida Ildeberto Muniz de

    2004-01-01

    Neste artigo analisam-se os laudos e dados obtidos das investigações de acidentes graves e fatais do trabalho efetuadas pelo Instituto de Criminalística (IC), Regional de Piracicaba. Foram analisados 71 laudos de acidentes ocorridos em 1998, 1999 e 2000. Os acidentes envolvendo máquinas representam 38,0%, seguido pelas quedas de altura (15,5%) e em terceiro lugar os causados por corrente elétrica (11,3%). Os laudos concluem que 80,0% dos acidentes são causados por "atos inseguros" cometidos p...

  11. Effects on cerebral circulation of decimeter wave therapy and variable magnetic field in patients with hemiparesis of vascular and traumatic origin

    Energy Technology Data Exchange (ETDEWEB)

    Strelkova, N.I.; Gavrilkov, A.T.; Dyuzhilova, N.F.; Strel' tsova, Ye.N.

    1981-08-01

    Both the artherosclerotic process in the case of cerebrovascular accident and cerebral trauma lead to impairment of cerebral hemodynamics, blood and spinal fluid circulation, macroscopic and microscopic disturbances. Electromagnetic waves in the decimeter range (decimeter waves - DMW) and a variable magnetic field (VMF) were used to treat these processes. Treatment was delivered directly to the region of the cerebral lesion, on the basis of the penetrating capacity of DMW and VMF to a relatively great depth (7 to 9 and 4 to 7 cm, respectively). Results of these treatments are discussed.

  12. Monitoring of cerebral haemodynamics in newborn infants

    DEFF Research Database (Denmark)

    Liem, K Djien; Greisen, Gorm

    2010-01-01

    The most important cerebrovascular injuries in newborn infants, particularly in preterm infants, are cerebral haemorrhage and ischemic injury. The typical cerebral vascular anatomy and the disturbance of cerebral haemodynamics play important roles in the pathophysiology. The term 'cerebral...... haemodynamics' includes cerebral blood flow (CBF), cerebral blood flow velocity, and cerebral blood volume (CBV). Therapy aimed at changing vascular anatomy is not available. Therefore, prevention of disturbances in CBF and CBV is pivotal. However, continuous monitoring of CBF and CBV is still unavailable for....... Using it even without knowing the exact level of CBF and CBV, it is possible to aim to keep CBF and CBV stable. Futureresearch should focus on development of monitoring tools, gaining more insight in neonatal cerebral autoregulation, and demonstrating clinical benefits of a 'cerebral perfusion...

  13. MRI in cerebral ischemia - value of FLAIR vascular hyperintensities and high-resolution diffusion-weighted imaging and risk factor analysis in athletes

    OpenAIRE

    Hohenhaus, Marc

    2014-01-01

    The importance of cerebral magnetic resonance imaging (MRI) in acute stroke has increased during the last years. The presented papers focus on improvement of the diagnostic workup of specific MRI sequences for additional information in acute stroke and on detecting risk factors for cerebral ischemic lesions in marathon runners. The diagnostic impact of specific vessel signs on MRI for prognostic and therapeutic questions is increasingly discussed. We evaluated the association of distal cor...

  14. Processo de cuidar de idosos com acidente vascular encefálico: sentimentos dos familiares envolvidos - DOI: 10.4025/actascihealthsci.v26i1.1614 The process of taking care of seniors with cerebral vascular accident: relatives’ feelings - DOI: 10.4025/actascihealthsci.v26i1.1614

    Directory of Open Access Journals (Sweden)

    Andréa Evangelista Lavinsky

    2004-04-01

    Full Text Available Envelhecer deixou de ser um fenômeno exclusivo dos países desenvolvidos e tornou-se comum também aos países em desenvolvimento, exigindo da família conhecimentos e habilidades para prevenir ou minimizar os efeitos da velhice e de patologias como o AVE. Propomos como objetivos identificar os sentimentos dos familiares envolvidos no cuidar desses idosos e analisá-los à luz da Teoria das Representações Sociais. Estudo descritivo, qualitativo realizado nos domicílios de idosos com AVE, em Itabuna-Ba, de julho de 2000 a julho de 2001. Os dados coletados por meio de entrevista semiestruturada foram trabalhados a partir da análise de conteúdo proposta por Bardin. Os sujeitos apresentaram-se envolvidos em um misto de sentimentos que envolve retribuição, amor, satisfação, medo, tristeza, pena, culpa, angústia, insegurança, nervosismo e impaciência ao cuidarem de seus familiares idosos. Esperamos contribuir com a reflexão sobre o cuidar de idosos em domicílio e o engajamento da enfermagem na orientação e no preparo técnico do familiar para o cuidado domiciliar.Aging is not an exclusive phenomenon of developed countries, but also of developing countries. Thus, the family must have knowledge and abilities to prevent or to minimize the effects of aging and also of pathologies as the CVA. The aim is to identify the relatives' feelings involved in taking care of the seniors and to analyze them according to the Theory of Social Representations. This descriptive, qualitative study was performed in the CVA seniors' homes, in Itabuna-BA, from July 2000 to July 2001. The data, collected through semi-structured interview, were analyzed according to the content analysis proposed by Bardin. The subjects are shown to be involved in a group of feelings that involve retribution, love, satisfaction, fear, sadness, grieves, blame, anguish, insecurity, nervousness and impatience when they take care of their senior relatives. Thus, we hope to contribute to the reflection on taking care of seniors in the home and the nursing engagement in the orientation and the relative's technical preparation for the home care.

  15. Cerebrovascular hemodynamics in patients with cerebral arteriosclerosis

    Institute of Scientific and Technical Information of China (English)

    Jianbo Yang; Changcong Cui; Chengbin Wu

    2011-01-01

    The present study observed hemodynamic changes in 26 patients with cerebral arteriosclerosis using a cerebral circulation dynamics detector and transcranial Doppler.In patients with cerebral arteriosclerosis the blood supply and flow rate in the bilateral carotid arteries and the blood flow rate in the anterior cerebral and middle cerebral arteries were similar to normal controls, but the cerebral vascular resistance, critical pressure and pulsatility index were increased, and cerebral arterial elasticity and cerebral blood flow autoregulation were decreased.Compared with the lesioned hemisphere of patients with cerebral infarction, the total blood supply and blood flow rate of patients with cerebral arteriosclerosis were higher.Compared with normal subjects, patients with cerebral arteriosclerosis exhibited cognitive disturbances, mainly in short-term memory, attention, abstract capability, and spatial and executive dysfunction.Results showed that cerebral arteriosclerosis does not directly affect the blood supply of a cerebral hemisphere, but affects cognitive function.The increased cerebral vascular resistance and reduced autoregulation of cerebral blood vessels may be important hemodynamic mechanisms of arteriosclerosis-induced cerebral infarction.

  16. Acidentes múltiplos como sintoma neurótico

    Directory of Open Access Journals (Sweden)

    Cicero Christiano de Sousa

    1947-06-01

    Full Text Available Assinalando o grande desenvolvimento atual da Medicina psicossomática, o A. chama a atenção para os casos em que a ação psicopatógena é indireta: do comportamento do doente resulta um dano qualquer ao seu organismo. Após recordar alguns casos na literatura cita o trabalho de Marbe que estabeleceu claramente, por meios estatísticos, que há pessoas mais sujeitas a acidentes do que outras. Para o A., de acordo com a gênese, os acidentes podem ser: 1 puramente casuais; 2 dependentes de falta de habilidade do indivíduo, ou de defeitos neurológicos; 3 constituir verdadeiros "atos falhados", comparáveis a lapsos da memória ou da linguagem, e causados por um conflito intrapsíquico de tendências conscientes ou inconscientes. Quando muito numerosos, os atos do último tipo constituem verdadeiro sintoma neurótico e evidentemente, só poderão ser afastados pela psicoterapia. O A. refere o caso de um operário que, em pouco mais de um ano de observação, sofreu 17 acidentes, de gravidade geralmente pequena. A tendência a se ferir era notada desde a adolescência. O exame mental revelou indivíduo com traços neuróticos acentuados: irritabilidade, dúvidas, inveja, ansiedade, fobias. O psico-diagnóstico de Rorschach confirmou tratar-se de um neurótico; em particular, todas as respostas são determinadas pela forma, sendo O: O o tipo de vivência; há 91% de F+; o tipo de percepção é G: (D: Dd; a seqüência é rígida; o choque de cores evidente no cartão II. Procurando dar uma explicação psicanalítica para o caso, e diante dos dados relativos à familia do paciente e à sua vida anterior, admite o A. que os acidentes indicam: 1 no plano mais profundo, uma agressividade pré-edipiana introjetada contra a mãe; 2 mais superficialmente, autocastração para se castigar dos desejos contidos no complexo de Édipo e evitar que se realizem; 3 mais superficialmente ainda, há a considerar o lucro secundário do sintoma, relativamente

  17. Clinical Neuroimaging of cerebral ischemia

    Energy Technology Data Exchange (ETDEWEB)

    Nakagawara, Jyoji [Nakamura Memorial Hospital, Sapporo (Japan)

    1999-06-01

    Notice points in clinical imaging of cerebral ischemia are reviewed. When cerebral blood flow is determined in acute stage of cerebral embolism (cerebral blood flow SPECT), it is important to find area of ischemic core and ischemic penumbra. When large cortex area is assigned to ischemic penumbra, thrombolytic therapy is positively adapted, but cautious correspondence is necessary when ischemic core is recognized. DWI is superior in the detection of area equivalent to ischemic core of early stage, but, in imaging of area equivalent to ischemic penumbra, perfusion image or distribution image of cerebral blood volume (CBV) by MRI need to be combined. Luxury perfusion detected by cerebral blood flow SPECT in the cases of acute cerebral embolism suggests vascular recanalization, but a comparison with CT/MRI and continuous assessment of cerebral circulation dynamics were necessary in order to predict brain tissue disease (metabolic abnormality). In hemodynamic cerebral ischemia, it is important to find stage 2 equivalent to misery perfusion by quantification of cerebral blood flow SPECT. Degree of diaschisis can indicate seriousness of brain dysfunction for lacuna infarct. Because cerebral circulation reserve ability (perfusion pressure) is normal in all areas of the low cerebral blood flow by diaschisis mechanism, their areas are easily distinguished from those of hemodynamic cerebral ischemia. (K.H.)

  18. Modified constraint-induced movement therapy and modified forced-use therapy for stroke patients are both effective to promote balance and gait improvements Terapia de constrição com indução do movimento e terapia de uso forçado modificadas em pacientes pós-acidente vascular encefálico são eficientes em promover melhora do equilíbrio e da marcha

    Directory of Open Access Journals (Sweden)

    Amanda C. Fuzaro

    2012-04-01

    Full Text Available BACKGROUND: Previous studies show that chronic hemiparetic patients after stroke, presents inabilities to perform movements in paretic hemibody. This inability is induced by positive reinforcement of unsuccessful attempts, a concept called learned non-use. Forced use therapy (FUT and constraint induced movement therapy (CIMT were developed with the goal of reversing the learned non-use. These approaches have been proposed for the rehabilitation of the paretic upper limb (PUL. It is unknown what would be the possible effects of these approaches in the rehabilitation of gait and balance. OBJECTIVES: To evaluate the effect of Modified FUT (mFUT and Modified CIMT (mCIMT on the gait and balance during four weeks of treatment and 3 months follow-up. METHODS: This study included thirty-seven hemiparetic post-stroke subjects that were randomly allocated into two groups based on the treatment protocol. The non-paretic UL was immobilized for a period of 23 hours per day, five days a week. Participants were evaluated at Baseline, 1st, 2nd, 3rd and 4th weeks, and three months after randomization. For the evaluation we used: The Stroke Impact Scale (SIS, Berg Balance Scale (BBS and Fugl-Meyer Motor Assessment (FM. Gait was analyzed by the 10-meter walk test (T10 and Timed Up & Go test (TUG. RESULTS: Both groups revealed a better health status (SIS, better balance, better use of lower limb (BBS and FM and greater speed in gait (T10 and TUG, during the weeks of treatment and months of follow-up, compared to the baseline. CONCLUSION: The results show mFUT and mCIMT are effective in the rehabilitation of balance and gait.CONTEXTUALIZAÇÃO: Pacientes hemiparéticos crônicos, após acidente vascular encefálico (AVE, apresentam incapacidade para executar movimentos no hemicorpo parético. Essa incapacidade é reforçada positivamente por tentativas fracassadas de movimento, conceito chamado desuso aprendido. A terapia de uso forçado (FUT e a terapia de constri

  19. Investigation and analysis of relevant knowledge needs among patients underwent cerebral vascular interventional therapy%脑血管介入治疗患者相关知识需求的调查分析

    Institute of Scientific and Technical Information of China (English)

    符晓艳; 周华东

    2010-01-01

    Objective To understand the relevant knowledge needs among patients underwent cerebral vascular interventional therapy, in order to provide a basis for developing targeted, personalized and standardized health education programs and canying out predictable care. Methods A total of 337 discharged cases with cerebral vascular interventional treatment wree surveyed by self-designed questionnaire. Results 100% of the patients had strong demands for interventional treatment of cerebral vascular in terms of surgical efffects and prognosis of the disease. The most common style of healthcare education was talking with doctors and nurses, understanding of relevant knowledge were generally insufficient, which revealed that these patients had some misunderstanding about the demand for healthcare. Conclusions Nurses should pay attention to relevant knowledge in patients, carrying on targeted diverse health education according to individual differences.%目的 了解脑血管介入治疗患者对相关知识的需求情况,为制定有针对性的个性化、规范化的健康教育计划、实施预见性护理提供依据.方法 采用自行设计的调查问卷,对337例脑血管介入治疗患者进行问卷调奁.结果 100%患者对手术效果和疾病预后有强烈需求.最受欢迎的健康宣教方式是与医护人员的直接交流.对脑血管介入治疗的相关知识普遍缺乏了解,显示患者对健康教育需求存在误区.结论 护理人员应重视对患者进行相关的知识宣教,根据不同的个体差异开展针对性、形式多样的健康教育.

  20. Clinical analysis of 22 cases of hypoglycemia similar to acute cerebral vascular disease%类似急性脑血管病的低血糖症22例临床分析

    Institute of Scientific and Technical Information of China (English)

    商杰; 徐宏; 毛九华

    2014-01-01

    Objective:To improve the understanding of damage in nervous system caused by hypoglycemia.Methods:We selected 22 cases of hypoglycemia patient.The clinical manifestation is similar to acute cerebral vascular disease.The head of CT,MRI and clinical data of the patients were retrospectively analyzed.Results:In 22 patients,the results of brain CT,MRI examination were negative,and the blood glucose was lower than 2.8mmol/L.After the treatment of Hypertonic glucose,symptoms and signs were disappeared.The manifestation of central nervous system of hypoglycemia were similar to the acute cerebral vascular disease,so it was easy to be misdiagnosed.Conclusion:When a person with diabetes suddenly appear similar symptom of acute cerebral vascular disease,we should give the quick check of head CT and MRI for them,at the same time,we should give the quick check of blood sugar,urine sugar,urine ketone for them in order to improve the early diagnosis rate of hypoglycemia and strive for the opportunity to treatment.%目的:提高对低血糖所致神经系统损害的认识。方法:收治22例低血糖症患者,临床表现类似急性脑血管病,对其头颅CT、MRI及临床资料进行回顾性分析。结果:22例患者头颅CT、MRI检查阴性,血糖<2.8mmol/L,给予高渗糖治疗,症状、体征均消失。结论:对于糖尿病患者突发类似急性脑血管病症状时,急查头颅CT、MRI的同时,应急检血糖、尿糖、尿酮体,以提高低血糖症的早期诊断率,为治疗争取时机。

  1. Patología cerebro-vascular hemorrágica en adultos asociada al consumo de cocaína Cerebral haemorrhage in adults associated with the use of cocaine

    Directory of Open Access Journals (Sweden)

    M. Blanco

    2005-07-01

    Full Text Available La cocaína es la segunda droga de comercio ilegal más consumida en España después del cannabis. El número de pacientes atendidos en los servicios de urgencias tras consumir cocaína y los casos de muerte secundarios al consumo de la misma han ido aumentando hasta multiplicarse por seis en los últimos años. El consumo de este alcaloide ocasiona efectos nocivos, constatados sobre diferentes órganos y sistemas corporales, e incluso la muerte. A nivel del SNC destaca, por su gravedad e incidencia, la patología cerebro-vascular hemorrágica (PCVH. Este tipo de cuadro se halla asociado al consumo de drogas ilícitas entre el 9,5% y el 34% de los accidentes vasculares en menores de 45 años, siendo la cocaína la más frecuentemente implicada en su presentación. Por otro lado, la rotura de un aneurisma o malformación arteriovenosa se ha detectado hasta en el 50% de los pacientes con PCVH secundarios al consumo de cocaína. Presentamos tres casos de muerte súbita en adultos por patología cerebro-vascular hemorrágica asociada al consumo de cocaína.Cocaine is the second most frequent illegal drug consumed in Spain after cannabis. A significant increase has occurred in the number of individuals treated in emergency departments after cocaine use just as in the number of cocaine-related deaths. These rates have been actually multiplied by six in the latest years. Cocaine causes injury in different organ systems, even death. In the CNS the use of cocaine is frequently associated with cerebral haemorrhage. Stroke in young adults below 45 years is usually related to drug use between 9,5% and 34% of cases, and cocaine is the most frequently mentioned drug. Otherwise, even 50% of cocaine-related stroke is the result of rupture of saccular aneurysms involving the arteries at the base of the brain and vascular malformation. In this paper, we present three cases of sudden death in adults due to cerebral haemorrhage associated with cocaine use.

  2. 全脑低灌注型血管性认知损害动物模型%Animal models of vascular cognitive impairment of global cerebral hypoperfusion

    Institute of Scientific and Technical Information of China (English)

    孟楠; 吕佩源

    2012-01-01

    血管性认知损害(vascular cognitive impairment,VCI)是指由血管危险因素、明显或不明显的脑血管病引起的从轻度认知损害到痴呆的一大类临床综合征.寻找一种生理学可控且可复制的动物模型,对于VCI病理生理学过程的系统研究以及新型治疗方法的评价至关重要.%Vascular cognitive impaiment (VCI) refers to a large class of clinical syndromes caused by vascular risk factors,obvious or not obvious cerebrovascular diseases from mild cognitive impairment to dementia.Looking for a physiologically controllable and repeatable animal model is critical for the systematic research of the VCI pathophysiological processes and the evaluation of new treatment methods.

  3. Protein kinase C inhibition prevents upregulation of vascular ET(B) and 5-HT(1B) receptors and reverses cerebral blood flow reduction after subarachnoid haemorrhage in rats

    DEFF Research Database (Denmark)

    Beg, Saema S; Hansen-Schwartz, Jacob A; Vikman, Petter J;

    2007-01-01

    The pathogenesis of cerebral ischaemia after subarachnoid haemorrhage (SAH) still remains elusive. The purpose of the present study was to examine whether specific protein kinas C (PKC) inhibition in rats could alter the transcriptional SAH induced Endothelin (ET) type B and 5-hydroxytryptamine......-CT; 5-HT(1) receptor agonist) were investigated with a myograph. The contractile responses to ET-1 and 5-CT were increased (PB) and 5-HT(1B) receptor mRNA and protein expression were significantly elevated after SAH, as analysed...... by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. Administration of RO-31-7549 prevented the upregulated contraction elicited by application of ET-1 and 5-CT in cerebral arteries and kept the ET(B) and 5-HT(1B) receptor mRNA and protein levels at pre-SAH levels. Regional...

  4. Demographic features and neuropsychological correlates in a cohort of 200 patients with vascular cognitive decline due to cerebral small vessel disease

    Directory of Open Access Journals (Sweden)

    Thomas Gregor Issac

    2016-01-01

    Full Text Available Introduction: Vascular dementia is the second most common form of dementia and is potentially reversible. Small vessel disease (SVD closely mimics degenerative dementia in view of its sub-acute onset and progressive course. Therefore, unlike large vessel disease, Hachinski Ischemic scale score may not always reflect vascular cognitive decline resulting in diagnostic and therapeutic confusions. Therefore, there is a need for detailed neuropsychological assessment for various cognitive domains for early identification of vascular cognitive decline as it carries a very good long term prognosis for cognitive morbidity, unlike degenerative dementias. Patients and Methods: This prospective study involves thorough domain based neuropsychological assessment of patients with a radiological diagnosis of SVD involving the following parameters-digit forward and backward, category fluency, color trails, stick test, logical memory test, and bender gestalt test. Magnetic resonance imaging scans done using 3-tesla machines and SVD graded using Fazekas visual scale. Results: The mean Hachinskis score was less sensitive for differentiating vascular dementia from degenerative dementia. However, the domain based neuropsychological scores were highly sensitive showing statistically significant impairment in all 6 domains tested and compared with Fazekas 1-3 grades in imaging. Discussion and Conclusion: This study aimed at establishing an early diagnosis of vascular mild cognitive impairment using domain wise neuropsychological testing and correlating it with radiological scores. Hachinskis score is more sensitive for large vessel disease in view of acute onset and step-like progression as against steady progression in SVD. However, domain-wise testing was highly sensitive in identifying early cognitive impairment in patients with SVD, and early therapeutic interventions are highly rewarding.

  5. Vascular Cures

    Science.gov (United States)

    ... our CEO Board of Directors Scientific Advisory Board History of Vascular Cures Impact Contact Us Vascular Disease What is Vascular Disease? Education and Awareness Vascular Diseases Abdominal Aortic Aneurysm Aortic ...

  6. The factors of mild vascular cognitive impairment in elderly patients with ischemic cerebral stroke%老年缺血性脑卒中后轻度血管性认知障碍的影响因素

    Institute of Scientific and Technical Information of China (English)

    王和平; 黄燕秋

    2016-01-01

    Objective To analyze the factors of mild vascular cognitive impairment (VCI) in elderly patients with ischemic cerebral stroke. Methods The general information ,physical examination ,cognitive evaluation and imaging data were collected and investigated;single factor analysis and Logistic regression analysis were used. Results The occurrence of mild VCI in eld-erly patients with ischemic cerebral stroke was related with age ,educational level ,coronary heart disease ,diabetes ,hyperten-sion ,stroke frequency ,disease location and area of stroke ,and had non-obvious relation with sex ,BMI ,smoking ,alcohol con-sumption. Logistic regression analysis showed that education was a protective factor for mild VIC in elderly patients with is-chemic cerebral stroke ,and age ,coronary heart disease ,diabetes ,hypertension ,stroke frequency ,disease location and area were the risk factors. Conclusion The risk factors for mild VCI in elderly patients with ischemic cerebral stroke are many ;targeted early intervention can be applied in clinic.%目的:分析老年缺血性脑卒中后轻度血管性认知障碍(VCI)的影响因素。方法对患者一般资料、体格检查、认知评估及影像学资料进行收集与调查,并行单因素分析与Logistic回归分析。结果老年缺血性卒中后轻度VCI的发生与患者年龄、文化程度、冠心病、糖尿病、高血压、卒中次数、发病部位及卒中面积有关;与性别、BM I、吸烟、饮酒等无明显相关。Logistic回归分析显示,文化程度为老年缺血性脑卒中后轻度VCI发生的保护因素,而年龄、冠心病、糖尿病、高血压、卒中次数、发病部位及卒中面积是危险因素。结论老年缺血性脑卒中后轻度 VCI发生的危险因素众多,临床上可进行针对性的早期干预。

  7. 老年缺血性脑卒中后轻度血管性认知障碍的影响因素%The factors of mild vascular cognitive impairment in elderly patients with ischemic cerebral stroke

    Institute of Scientific and Technical Information of China (English)

    王和平; 黄燕秋

    2016-01-01

    目的:分析老年缺血性脑卒中后轻度血管性认知障碍(VCI)的影响因素。方法对患者一般资料、体格检查、认知评估及影像学资料进行收集与调查,并行单因素分析与Logistic回归分析。结果老年缺血性卒中后轻度VCI的发生与患者年龄、文化程度、冠心病、糖尿病、高血压、卒中次数、发病部位及卒中面积有关;与性别、BM I、吸烟、饮酒等无明显相关。Logistic回归分析显示,文化程度为老年缺血性脑卒中后轻度VCI发生的保护因素,而年龄、冠心病、糖尿病、高血压、卒中次数、发病部位及卒中面积是危险因素。结论老年缺血性脑卒中后轻度 VCI发生的危险因素众多,临床上可进行针对性的早期干预。%Objective To analyze the factors of mild vascular cognitive impairment (VCI) in elderly patients with ischemic cerebral stroke. Methods The general information ,physical examination ,cognitive evaluation and imaging data were collected and investigated;single factor analysis and Logistic regression analysis were used. Results The occurrence of mild VCI in eld-erly patients with ischemic cerebral stroke was related with age ,educational level ,coronary heart disease ,diabetes ,hyperten-sion ,stroke frequency ,disease location and area of stroke ,and had non-obvious relation with sex ,BMI ,smoking ,alcohol con-sumption. Logistic regression analysis showed that education was a protective factor for mild VIC in elderly patients with is-chemic cerebral stroke ,and age ,coronary heart disease ,diabetes ,hypertension ,stroke frequency ,disease location and area were the risk factors. Conclusion The risk factors for mild VCI in elderly patients with ischemic cerebral stroke are many ;targeted early intervention can be applied in clinic.

  8. Cerebral Hypoxia

    Science.gov (United States)

    ... Enhancing Diversity Find People About NINDS NINDS Cerebral Hypoxia Information Page Synonym(s): Hypoxia, Anoxia Table of Contents ( ... Trials Organizations Publicaciones en Español What is Cerebral Hypoxia? Cerebral hypoxia refers to a condition in which ...

  9. Initial experience with a reversal-of-flow cerebral protection device in carotid angioplasty Experiência inicial com dispositivo de reversão de fluxo para proteção cerebral na angioplastia carotídea

    Directory of Open Access Journals (Sweden)

    Sidnei José Galego

    2013-03-01

    Full Text Available PURPOSE: To report initial findings with the GORE Flow Reversal System®, with a focus on major/minor adverse events in the 30 first postoperative days. METHODS: The first 24 patients submitted to carotid angioplasty using the GORE system, from June 2010 to May 2012, were retrospectively assessed with regard to indications, anatomic details, technical difficulties, and early clinical outcomes, including major (stroke, death, acute myocardial infarction and minor (hematoma adverse events. RESULTS: Systemic hypertension was present in 100% of the patients, diabetes mellitus in 58.3%, and coronary disease in 37.5%. Type II aortic arch was encountered in 62.5% of the patients and atherosclerotic lesion predominantly at the carotid bifurcation affecting the internal and common carotid arteries in 79.2%. Angiographic data revealed contralateral carotid arteries with OBJETIVO: Relatar os achados iniciais da utilização do GORE Flow Reversal System® (Sistema de Fluxo de Reversão, com foco em eventos adversos maiores/menores nos primeiros 30 dias do pós-operatório. MÉTODOS: Os primeiros 24 pacientes submetidos a angioplastia carotídea com a utilização do sistema GORE, de junho de 2010 a maio de 2012, foram avaliados retrospectivamente com relação a indicações, detalhes anatômicos, dificuldades técnicas e desfechos clínicos imediatos, incluindo eventos adversos maiores (acidente vascular cerebral, morte, infarto agudo do miocárdio e menores (hematoma. RESULTADOS: Hipertensão sistêmica estava presente em 100% dos pacientes, diabete melito em 58,3% e doença coronariana em 37,5%. Arco aórtico tipo II foi encontrado em 62,5% dos pacientes e lesão de aterosclerose predominantemente na bifurcação carotídea que afeta as artérias carótidas internas e comuns em 79,2%. Dados angiográficos revelaram artérias carótidas contralaterais com estenose <50% em 95,8% de casos e preservação de fluxo sanguíneo cerebral em 95,8%. Todos os

  10. Bobath、Brunnstrom、Rood及PNF技术对脑血管病迟缓期的康复疗效观察%Efficacy Observation on Bobath, Brunnstrom, Rood and PNF Technique on Rehabilitation of Cerebral Vascular Diseases in Lag Phase

    Institute of Scientific and Technical Information of China (English)

    黄妃凤; 朱炯端; 谭明芳; 孙芳; 成晓霞

    2014-01-01

    目的:观察Bobath技术、Brunnstrom技术、Rood技术及PNF技术对脑血管病迟缓期的康复疗效。方法:85例患者随机分为Bobath技术组、Rood技术组、Brunnstrom技术组、PNF技术组和对照组,五组均接受基础治疗至迟缓期结束,四组技术组分别予以相应的康复技术,治疗前后采用FMA、MBI进行康复评定,并记录迟缓期持续的时间。结果:治疗后五组患者FMA、MBI评分均较治疗前显著升高(P<0.05),且四组技术组MBI评分均显著高于对照组(P<0.05);四组技术组迟缓期持续时间均显著少于对照组(P<0.05)。结论:脑血管病迟缓期患者早期介入Bobath技术、Brunnstrom技术、Rood技术或PNF技术均可缩短迟缓期持续时间,促进患者肢体功能恢复,提高日常生活活动能力;且四种康复技术对脑血管病迟缓期患者的康复疗效相当,可康复治疗中灵活运用。%Objective:To study the rehabilitation efficacy of Bobath, Brunnstrom, Rood and PNF technique on rehabilitation of cerebral vascular dis-eases in lag phase. Methods:85 patients were randomly divided into Bobath group, Rood group, Brunnstrom group, PNF group and control group, five groups received basic treatment until the lag phase ended, four technique groups with corresponding rehabilitation technology, rehabilitation evaluation was made before and after treatment with FMA and MBI, and the duration of lag phase was recorded. Results:The FMA、MBI scores of five groups after treatment were all significantly higher than those before treatment (P<0.05);MBI scores of four technique group were all signifi-cantly higher than that of control group (P<0.05);duration of lag phase of four technique group were all significantly lower than that of control group (P<0.05). Conclusion:Cerebral vascular disease of lag phase with early intervention of Bobath, Brunnstrom, Rood and PNF technique can shorten duration of lag phase, promote the limb

  11. Relationship between cardio-ankle vascular index and cerebral atrophy in elderly hypertensive patients%老年高血压患者心踝血管指数与脑萎缩的关系研究

    Institute of Scientific and Technical Information of China (English)

    王晓兵; 张薇; 田国祥; 张海娟

    2013-01-01

    目的:探讨老年高血压患者心踝血管指数(cardio-ankle vascular index,CAVI)与脑萎缩发生率及萎缩程度的关系。方法纳入2010年1月~2013年1月北京军区总医院老年高血压患者193例,所有患者年龄>60岁。按照CAVI值分为实验组(CAVI≥9.0,n=110)和对照组(CAVI<9.0,n=83),比较两组脑萎缩发生率及脑萎缩程度(包括哈氏值、前角指数、脑室指数、侧脑室体部指数、侧脑室体部宽度)的差异。结果与对照组相比,实验组脑萎缩的发生率更高(27.27%vs.18.07,P<0.05),同时哈氏值更高[(60.12±5.88)mm vs.(54.21±5.14)mm,P=0.011]、前角指数更低[(3.34±0.35)vs.(3.61±0.29),P=0.024]、侧脑室体部指数和侧脑室体部宽度指数更低[(3.66±0.38) vs.(4.21±0.34), P=0.019;(3.39±0.28) vs.(3.65±0.35),P=0.033]。结论 CAVI值增高有助于评估老年高血压患者脑萎缩风险,并对萎缩程度具有一定的预测价值。%Objective To investigate the relationship between cardio-ankle vascular Index (CAVI) and the incidence of cerebral atrophy or atrophy severity in elderly patients with hypertension. Methods The patients (n=193, aged over 60) were chosen from the General Hospital of PLA Beijing Military Area Command from Jan. 2010 to Jan. 2013, and divided into test group (CAVI≥9.0, n=110) and control group (CAVI<9.0, n=83). The differences in the incidence of cerebral atrophy and atrophy severity were compared between two groups. Results Compared with control group, the incidence of cerebral atrophy was higher (27.27% vs. 18.07, P<0.05), Hartz index was higher [(60.12±5.88) mm vs. (54.21±5.14) mm, P=0.011], frontal horn index was lower [(3.34±0.35) vs. (3.61±0.29), P=0.024], lateral ventricle body index [(3.66±0.38) vs. (4.21±0.34), P=0.019] was lower, and width index of lateral ventricle body was lower [(3.39±0.28) vs. (3.65±0.35), P=0.033] in test group

  12. 血管壁和血管内皮细胞超微结构在急性机械性脑血管痉挛早期的变化%Ultrastructural changes in vascular wall and vascular endothelial cells during early stage of acute mechanical cerebral vasospasm

    Institute of Scientific and Technical Information of China (English)

    陆菁菁; 张邵东; 翟晶; 万虹

    2007-01-01

    BACKGROUND:Cerebrovascular drag, occlusion and other mechanical stimulations inevitably occur during some craniocerebral operations, which cause acute mechanical cerebrovascular vasospasm. At present, the mechanism underlying the patho-physiology as well as the pathological prognosis of this acute mechanical vasospasm remains unclear.OBJECTIVE: To observe changes in the vascular diameter of the middle cerebral artery, cerebral blood flow (CBF), and ultrastructure of vascular wall and vascular endothelial cells, during the early stage (2 hours) of mechanical cerebral vasospasm in cats.DESIGN: Open experiment.SETTING: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University; Beijing Institute of Neurosurgery.MATERIALS: Six healthy adult hybrid cats, of either gender, weighing from 2.5 to 3.5 kg, were provided by the China Medical Science Institute of Experimental Animals. Laser Doppler flowmetry (Periflux 5010, Sweden Perimed Company)was used.METHODS: This study was carried out in the Beijing Institute of Neurosurgery between August 2005 and March 2006. For all experimental surgical procedures, the cats were anesthetized by intraperitoneal injection of 200 g/L chloral hydrate, at 2 mL/kg, and then placed in a prone position. A median incision was made in the scalp and a square bone window, 8×10 mm, was opened at 1.5 cm posterior and 1.5 lateral to the anterior fontanel, after which the dura mater was pricked out. The fine detecting head of the Laser Doppler flowmetry was fixed to a region of the cerebral surfacewith no vessels or with only a few vessels. Subsequently, the cats were placed in lateral position. Under the surgical microscope, the right middle cerebral artery was exposed through a suborbital approach. Blunt apparatus was used to stimulate middle the middle cerebral artery repeatedly, at a frequency of 100 time/min within 30 minutes.The diameter of the middle cerebral artery was measured and a perfusion index of cortical brain tissue

  13. Clinical analysis of hematoma enlargement in patients with hypertensive cerebral hemorrhage cerebral vascular CTA prediction%脑血管CTA预测高血压脑出血患者血肿扩大的临床探析

    Institute of Scientific and Technical Information of China (English)

    王建; 刘世芳; 曾征; 涂桂英

    2013-01-01

    objective:to study the cerebral CTA predict hematoma enlargement of hypertensive cerebral hemorrhage patients clinical value. Methods:60 cases of high blood pressure in patients with acute cerebral hemorrhage as the research object, CT scan and CTA enhanced spiral scanning, was in hospital (within 6 h), 24 h after onset appointment, statistical check twice the hematoma volume, key points of positive cases and visit the hematoma expansion of positive cases. Results:both the points patients positive for hematoma volume is significantly higher than patients negative (t =6.819,P <0.01), new point) positive patients, visit the hematoma expansion patients negative, positive rate was significantly higher than point visit hematoma expansion of positive rate (χ2=8.458, P <0.01), and the hematoma volume was also significantly higher than the latter (t =2.341,P <0.05). Conclusion:for patients hospitalized time earlier, CTA for evaluating hematoma expansion aspect, has the high reference value, worthy of clinical thinking.%目的探讨脑血管CTA预测高血压脑出血患者血肿扩大的临床价值。方法60例高血压急性脑出血患者作为研究对象,进行CT平扫和CTA增强螺旋扫描,于入院时(发病6h内)初诊一次,发病24h后复诊1次,统计两次检查的血肿量,初诊时的点征阳性例数和复诊时的血肿扩大阳性例数。结果初诊点征阳性患者血肿量显著高于点征阴性患者(t=6.819,P<0.01),初诊点征阳性患者,复诊血肿扩大阳性率显著高于初诊点征阴性患者,复诊血肿扩大阳性率(χ2=8.458, P<0.01),且血肿量也显著高于后者(t=2.341,P<0.05)。结论对于入院时间较早的患者来说,CTA对于评估血肿扩大可能性方面,具有较高的参考价值,值得临床考虑。

  14. Fatores associados a acidentes de trabalho envolvendo trabalhadores informais do comércio

    Directory of Open Access Journals (Sweden)

    Marcela Andrade Rios

    2015-06-01

    Full Text Available O estudo objetivou estimar a incidência de acidentes de trabalho não fatais sobre trabalhadores informais do comércio e analisar os fatores associados a esses eventos quanto aos aspectos sociodemográficos, ocupacionais, condições laborais e de saúde. Realizou-se estudo transversal com 434 trabalhadores em área comercial do Município de Jequié, Bahia, Brasil, em 2013. A regressão logística foi utilizada para avaliar os possíveis fatores associados ao acidente. Estimou-se a incidência de acidentes de trabalho (nos últimos 12 meses em 32,3%, e a análise multivariada revelou maior chance de ocorrência de acidente entre trabalhadores do sexo masculino (OR = 1,61, jovens (OR = 4,62, comerciantes de carnes/frangos (OR = 9,55 e aqueles que apresentam alto esforço físico (OR = 1,71. Com a análise dos resultados, verifica-se a necessidade de políticas públicas voltadas para a prevenção de acidentes no setor informal comércio.

  15. Tuberculoma cerebral Cerebral tuberculoma

    OpenAIRE

    ELIZABETH CLARA BARROSO; TÂNIA REGINA BRÍGIDO DE OLIVEIRA; ANA MARIA DANTAS DO AMARAL; VALÉRIA GÓES FERREIRA PINHEIRO; ANA LÚCIA DE OLIVEIRA SOUSA

    2002-01-01

    Relata-se o caso de paciente com crises convulsivas de início recente. A tomografia computadorizada cerebral evidenciou imagem sugestiva de lesão expansiva metastática frontoparietal direita. A investigação de tumor primário ou outra doença foi negativa e o exame histopatológico do tecido cerebral diagnosticou tuberculoma. As convulsões foram controladas com a associação de hidantoína 300mg/dia ao esquema específico, utilizado por 18 meses. A tuberculose do sistema nervoso central representa ...

  16. Cerebral emboli and depressive symptoms in dementia.

    NARCIS (Netherlands)

    Purandare, N.; Oude Voshaar, R.C.; Hardicre, J.; Byrne, J.; McCollum, C.N.; Burns, A.

    2006-01-01

    BACKGROUND: The vascular depression hypothesis and our recent findings of increased frequency of spontaneous cerebral emboli in dementia suggest that such emboli may be involved in the causation of depressive symptoms in dementia. AIMS: To evaluate the association between spontaneous cerebral emboli

  17. 蛛网膜下腔出血后脑痉挛的临床研究及CT征象分析%Clinical Study of Cerebral Vascular Spasm after Subarachnoid Hemorrhage and Analysis of CT Findings

    Institute of Scientific and Technical Information of China (English)

    李伟钦; 郑华英; 朱玉莉; 江晨辉

    2016-01-01

    Objective To analyze the clinical characteristics and CT findings of cerebral vascular spasm (CVS) after subarachnoid hemorrhage (SAH).Methods The clinical data of 54 patients with SAH who were treated in our hospital between February 2010 and May 2015 were collected. All patients were examined by CT and digital subtraction angiography (DSA) after admission, and the clinical data were complete. With DSA as the golden standard, the accuracy of CT in the diagnosis of CVS after SAH was statistically analyzed. The CT imaging findings were summarized.Results There was 1 cases with ACA, MCA distal segment CVS missed diagnosed by CTA, and the accuracy rate in the diagnosis of CVS was 88.24%, slightly lower than that of DSA (P>0.05); CBV and CBF in patients with SAH and CVS were lower than those in patients with SAH and without CVS (P0.05);SAH并CVS者CBV、CBF低于SAH无CVS者(P<0.05),其MTT、TTP明显长于SAH无CVS者,对比差异有统计学意义(P<0.05)。结论 SAH后CVS患者脑灌注降低,MTT、TTP延长,痉挛血管可见均匀性狭窄,采用CT、CTP诊断与DSA符合率高,可为临床诊治提供影像学依据。

  18. Acidentes de trabalho com profissionais de saúde de um hospital universitário Work accidents among healthcare professionals in a university hospital

    OpenAIRE

    Hanne Alves Bakke; Nelma Mirian Chagas de Araújo

    2010-01-01

    Esta pesquisa almejou estudar os registros de acidentes de trabalho envolvendo profissionais de saúde em um hospital universitário, determinando as categorias profissionais com maiores índices de ocorrências e os setores mais críticos da organização. Os dados dos registros de acidentes analisados foram: sexo, idade, profissão, local do acidente, tipo de acidente, agente da lesão, área afetada e número de horas entre o início da jornada e a ocorrência do acidente. Os documentos foram obtidos a...

  19. MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain.

    Science.gov (United States)

    Christen, T; Pannetier, N A; Ni, W W; Qiu, D; Moseley, M E; Schuff, N; Zaharchuk, G

    2014-04-01

    In the present study, we describe a fingerprinting approach to analyze the time evolution of the MR signal and retrieve quantitative information about the microvascular network. We used a Gradient Echo Sampling of the Free Induction Decay and Spin Echo (GESFIDE) sequence and defined a fingerprint as the ratio of signals acquired pre- and post-injection of an iron-based contrast agent. We then simulated the same experiment with an advanced numerical tool that takes a virtual voxel containing blood vessels as input, then computes microscopic magnetic fields and water diffusion effects, and eventually derives the expected MR signal evolution. The parameter inputs of the simulations (cerebral blood volume [CBV], mean vessel radius [R], and blood oxygen saturation [SO2]) were varied to obtain a dictionary of all possible signal evolutions. The best fit between the observed fingerprint and the dictionary was then determined by using least square minimization. This approach was evaluated in 5 normal subjects and the results were compared to those obtained by using more conventional MR methods, steady-state contrast imaging for CBV and R and a global measure of oxygenation obtained from the superior sagittal sinus for SO2. The fingerprinting method enabled the creation of high-resolution parametric maps of the microvascular network showing expected contrast and fine details. Numerical values in gray matter (CBV=3.1±0.7%, R=12.6±2.4μm, SO2=59.5±4.7%) are consistent with literature reports and correlated with conventional MR approaches. SO2 values in white matter (53.0±4.0%) were slightly lower than expected. Numerous improvements can easily be made and the method should be useful to study brain pathologies. PMID:24321559

  20. Change of cerebral blood flow distribution and vascular reserver according to age in Koreans measured by Tc-99m HMPAO brain SPECT

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate the normal values of regional cerebral blood flow (rCBF) and cerebrovascular reserve (CVR) in normal children to aged volunteers using Tc-99m HMPAO. Thirty four right-handed normal volunteers (20 males, 14 females, mean age 40.3±24.9 years, range 4 to 82 years) were underwent rest/acetazolamide (ACZ) brain SPECT using Tc-99m HMPAO and the sequential injection and subtraction method. rCBF was estimated on the basis of a semiquantitative approach by means of right/left ratio, region/cerebellum and region to whole brain ratios in frontal, parietal, temporal, and occipital lobes, basal ganglia, thalami, and cerebellum. CVR was measured by means of % perfusion increase calculated as % mean count change compared to rest rCBF in each regions. Mean values of right to left ratios range from 1.004 to 1.018. rCBF was highest in cerebellum and lowest in basal ganglia and thalami. Frontal and temporal rCBF decreased while occipital and thalamic rCBF increased according to age. No sexual difference of rCBF was noted. Mean CVR was 29.9±12.9%. Mean CVR significantly increased to late teens, and declined thereafter. After 6th decade, CVR in both frontal lobes, left parietal lobe and right basal ganglia decreased significantly with advancing age. There was no sexual difference of CVR. Quantitative assessment of CVR was possible by ACZ Tc-99m MHPAO brain SPECT. It revealed that rCBF and CVR changed according to age in normal Korean volunteers. There was no sexual difference

  1. EPIDEMIOLOGIA DOS ACIDENTES COM ANIMAIS PEÇONHENTOS REGISTRADOS EM NOVA XAVANTINA – MT

    Directory of Open Access Journals (Sweden)

    Vivian Tallita Pinheiro Santana

    2015-11-01

    Full Text Available Justificativa e objetivo: No Brasil os acidentes com animais peçonhentos constituem um problema de Saúde Pública, principalmente em municípios do interior do país. Informações regionais atualizadas são importantes para o desenvolvimento de ações de vigilância epidemiológica. Através desta pesquisa determinaram-se os aspectos epidemiológicos dos acidentes com animais peçonhentos registrados no município de Nova Xavantina, Mato Grosso, entre janeiro de 2007 e maio de 2013. Método: Foi realizado um estudo epidemiológico transversal, não probabilístico. Resultados: No período estudado foram registrados 68 acidentes, destes 44 ocasionados por serpentes, 19 por escorpiões e quatro por aranhas. A maioria dos acidentes com serpentes foram provocadas pelos gêneros Bothrops (79,5%, Crotalus (11,5% e Micrurus (2,3%. Quanto às vítimas, prevaleceram indivíduos do sexo masculino (76,5%, na faixa etária entre 30 a 49 anos (41,2%, de raça parda (72,1%, com ensino fundamental (55,9% envolvidos em atividades do campo como agricultura e pecuária (41,2%. Predominaram os acidentes de gravidade moderada (48,5% e todos os casos graves foram provocados por serpentes. Na maioria dos agravos (75,0%, não foi registrada relação entre o acidente e a atividade ocupacional. As regiões corpóreas mais atingidas foram pé (39,7%, perna (20,6% e mão (11,8%. As manifestações locais predominantes foram dor, edema e equimose. As manifestações sistêmicas de maior ocorrência foram hemorrágicas e vagais. Conclusão: Portanto, o período avaliado foi caracterizado pelo predomínio de acidentes com serpentes, no sexo masculino, em atividades do campo e de gravidade moderada. Assim, campanhas educativas e a adoção de medidas de prevenção são fundamentais para diminuir o registro desses agravos neste município. DESCRITORES: Envenenamento; Acidente ofídico; Picadas de escorpião.

  2. Caracterização dos acidentes de trabalho graves no Estado do Paraná

    OpenAIRE

    Scussiato, Louise Aracema

    2013-01-01

    Resumo: Os acidentes de trabalho graves, entendidos como aqueles que ocasionam lesões graves podem causar incapacidade física ou funcional, parcial, temporária ou permanente ou mesmo levar a morte, sendo considerado um problema de saúde pública no Brasil. Este estudo objetivou caracterizar os acidentes de trabalho graves ocorridos no Estado do Paraná entre 2007 e 2010; e caracterizar o perfil dos trabalhadores acidentados, segundo os ramos de atividade. Trata-se de um estudo epidemiológico de...

  3. Cerebral Palsy

    Science.gov (United States)

    Cerebral palsy is a group of disorders that affect a person's ability to move and to maintain balance ... do not get worse over time. People with cerebral palsy may have difficulty walking. They may also have ...

  4. Recuperação da motricidade voluntária do membro superior de pacientes com hemiplegia após acidente vascular cerebral: avaliação prognostica Recovery of voluntary motion in upper extremity following hemiplegia in patients with cerebrovascular accident: contribution to the prognosis

    Directory of Open Access Journals (Sweden)

    Abrão Anghinah

    1976-06-01

    Full Text Available O estudo tem por finalidade o registro e a análise dos principais fatos que ocorrem durante a recuperação da motricidade voluntária do membro superior em pacientes com hemiplegia após AVC, tendo por objetivo contribuir para a avaliação do prognóstico. De particular interesse foi a observação comparativa do retorno espontâneo da motricidade voluntária nos vários segmentos do membro superior em 88 pacientes com hemiplegia após AVC hospitalizados na fase aguda da afecção. Dos 88 pacientes hemiplégicos estudados, com diagnóstico suficientemente esclarecido e evolução acompanhada durante período satisfatório para permitir conclusões, 56 casos (grupo 1 atingiram melhora clínica, com remissão parcial ou completa da sintomatologia neurológica (discreto deficit de força, hiperreflexia e hipertonia e recuperação de todos os movimentos voluntários nas várias articulações do membro superior, enquanto 32 pacientes (grupo 2 com persistência da sintomatologia neurológica, particularmente a hipertonia, apresentaram melhora clínica discreta e recuperação parcial de movimentos do membro superior. A quantificação clínica de sinais neurológicos utilizada no presente estudo, tornou possível registrar as modificações mais importantes ocorridas durante a evolução dos 88 pacientes. Este critério permitiu destacar quantitativamente a regressão espontânea da sintomatologia e a determinação do nível crítico de estabilização (platô. A análise dos dados fornecidos pelos dois grupos estudados permitiu concluir que: o ponto crítico de regressão da sintomatologia e recuperação da motricidade voluntária ocorre em média, 70 dias após ter-se instalado a hemiplegia; o cômputo médio de 256 pontos, que foi obtido 70 dias após a instalação da hemiplegia, representa o nível crítico de estabilização; embora a precocidade de aparecimento de movimentos iniciais logo após a instalação da hemiplegia seja dado importante para o prognóstico, o autor acredita ser de capital importância a caracterização dos tipos de movimentos iniciais. Levando em conta os tipos de movimentos iniciais o autor observou que, quando nos pacientes com hemiplegia após AVC, os movimentos de flexo-extensão e oponência do polegar aparecem precocemente de forma isolada ou associada a movimentos da articulação proximal (ombro, ou central (cotovelo é de esperar melhor prognóstico do que nos pacientes cujo movimento inicial é representado por flexão do cotovelo e/ou flexão-adução do braço.The study aims the registration and analysis of the main facts which occur during recovery of the voluntary movements in the upper extremity, in patients with hemiplegia following cerebrovascular accident, and it also intends to evaluate the prognosis. Of particular interest was the comparative recognition of the spontaneous recovery of voluntary motricity in different segments of the upper extremity in 88 patients, not previously selected, with hemiplegia after cerebrovascular accident, admitted to the hospital at the acute stage. Of the 88 hemiplegic patients studied whose further evolution has been fairly followed 56 cases (group 1 experienced clinical improvement, either with partial or total remission of neurological manifestations and complete recovery of all voluntary movements in the different upper extremity joints, while 32 patients (group 2 with persistent neurological symptoms, particularly spasticity, showed a slighter clinical improvement, as well as only partial recovery of upper extremity movements. The clinical quantification of neurological signs applied in this study, has made possible to report the main significant changes developed during the 88 patients recovery. This criteria has allowed to enphasize the degree of the spontaneous remission of symptoms and the determination of the critical level of stabilization "plateau". The analysis of the data supplied by the two groups led to the following conclusions: a the critical level of remission of symptoms and the spontaneous recover

  5. Botulinum toxin A and physiotherapy intervention in the treatment of the painful shoulder after stroke: case report
    Toxina botulínica A e intervenção fisioterapêutica no tratamento do ombro doloroso pós acidente vascular cerebral: relato de caso

    OpenAIRE

    Suellen M. Marinho dos Santos Andrade; Mayara Dinamine França Dantas; Cristina Katya Dantas Torres; Karen Lúcia de Araújo Freitas Moreira

    2007-01-01

    The syndrome of the painful shoulder is considered a common finding in patients who suffered stroke. Several therapeutic modalities are suggested for the improvement of the patients’ clinical condition. In this report, a case of syndrome of the painful shoulder will be discussed, whose treatment consisted of the use of botulinum toxin A associated to physiotherapy. After a four-month treatment, significant improvements occurred concerning pain, spasticity, range of motion and quality of life,...

  6. Via, homem e veiculo: fatores de risco associados a gravidade dos acidentes de transito

    Directory of Open Access Journals (Sweden)

    Rosa Livia Freitas de Almeida

    2013-08-01

    Full Text Available OBJETIVO Analisar as características das vítimas, vias e veículos envolvidos em acidentes de trânsito e os fatores de risco de acidentes com ocorrência de óbito.  MÉTODOS Estudo de coorte não concorrente considerando os acidentes de trânsito em Fortaleza, CE, de janeiro de 2004 a dezembro de 2008. Foram utilizados dados do Sistema de Informação de Acidente de Trânsito de Fortaleza, do Sistema de Informações de Mortalidade, do Sistema de Informações Hospitalares e dos bancos de dados de Habilitação e Veículos do Departamento Estadual de Trânsito. Técnicas de relacionamento determinístico e probabilístico foram aplicadas para integrar as bases de dados. Efetuou-se a análise descritiva das variáveis relativas às pessoas, às vias, aos veículos e ao tempo. Foram utilizados os modelos lineares generalizados na investigação de fatores de risco para óbito por acidente de trânsito. O ajuste do modelo foi verificado pela razão de verossimilhança e análise ROC.  RESULTADOS Registraram-se 118.830 acidentes no período. Predominaram colisão/abalroamento (78,1%, atropelamentos (11,9% e choque com obstáculo fixo (3,9% e com motocicletas (18,1%. Ocorreram óbitos em 1,4% dos acidentes. Estiveram independentemente associados ao óbito por acidente de trânsito: bicicletas (OR = 21,2; IC95% 16,1;27,8, atropelamentos (OR = 5,9; IC95% 3,7;9,2, choque com obstáculo fixo (OR = 5,7; IC95% 3,1;10,5 e acidentes com motociclistas (OR = 3,5; IC95% 2,6;4,6. Os principais fatores contribuintes foram envolvimento de uma única pessoa (OR = 6,6; IC95% 4,1;10,73, presença de condutores não habilitados (OR = 4,1; IC95% 2,9;5,5 um único veículo envolvido (OR = 3,9; IC95% 2,3;6,4, sexo masculino (OR = 2,5; IC95% 1,9;3,3, tráfego em vias de jurisdição federal (OR = 2,4; IC95% 1,8;3,7, horário madrugada (OR = 2,4; IC95% 1,8;3,0 e dia de domingo (OR = 1,7; IC95% 1,3;2,2, todas ajustadas segundo modelo log-binomial.  CONCLUSÕES As a

  7. The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats.

    Science.gov (United States)

    Cao, Yanjing; Liang, Lizhen; Xu, Jian; Wu, Jiali; Yan, Yongxing; Lin, Ping; Chen, Qiang; Zheng, Fengming; Wang, Qin; Ren, Qian; Gou, Zengmei; Du, Yifeng

    2016-05-01

    Flavonoids have been shown to improve cognitive function and delay the dementia progression. However, the underlying mechanisms remain elusive. In the present study, we examined the effect of Scutellaria baicalensis stem-leaf total flavonoids (SSTFs) extracted from S. baicalensis Georgi on spatial learning and memory in a vascular dementia (VaD) rat model and explored its molecular mechanisms. The VaD rats were developed by permanent bilateral occlusion of the common carotid artery. Seven days after recovery, the VaD rats were treated with either 50 or 100 mg/kg of SSTF for 60 days. The spatial learning and memory was evaluated in the Morris water maze (MWM) test. The tau hyperphosphorylation and the levels of the related protein kinases or phosphatases were examined by western blot analysis. In VaD rats, SSTF treatment at 100 mg/kg significantly reduced the escape latency in training trial in MWM test. In the probe trial, SSTF treatment increased the searching time and travel distance in the target quadrant. SSTF treatment inhibited the tau phosphorylation in both cortex and hippocampus in VaD rats. Meanwhile, SSTF reduced the activity of glycogen synthase kinase 3β and cyclin-dependent kinase 5 in VaD rats. In contrast, SSTF treatment increased the level of the protein phosphatase 2A subunit B in VaD rats. SSTF treatment significantly improved the spatial cognition in VaD rats. Our results suggest that SSTF may alleviate tau-hyperphosphorylation-induced neurotoxicity through coordinating the activity of kinases and phosphatase after a stroke. SSTF may be developed into promising novel therapeutics for VaD. PMID:27118553

  8. Transient acute renal failure and functional hemispheric depression after cerebral arteriography in diabetic patients

    DEFF Research Database (Denmark)

    Olsen, Tom Skyhøj; Lund, P; Praestholm, J

    1981-01-01

    Cerebral angiography was carried out in two diabetic patients in the evaluation of minor vascular ischemic episodes. A transient acute renal failure following cerebral angiography was accompanied by a transient comatose episode with severe unilateral neurological deficits. A functional depression...

  9. Rabbit focal cerebral ischemia model established by vascular interventional method%血管内介入技术制作兔局灶性脑缺血模型

    Institute of Scientific and Technical Information of China (English)

    陈丽; 戴炯; 严国锋; 沈加林; 邱永明; 许建荣; 陈学进; 江基尧

    2012-01-01

    were stained with 2, 3, 5-Triphenyltetrazolium chloride (TTC), and the conditions of infart lesions were observed. The left rabbits were sacrificed 2 weeks after operation, HE staining was performed for brain tissues, and the occlusion of middle cerebral artery and pathological changes of brain tissues were evaluated. Results Symptoms of hemiplegia emerged in rabbits of model group, and the success rate of model establishment was 94. 12% . TTC staining of brain sections confirmed there were infart lesions 6 h after operation, and the extent of infarct lesions tended to be stable 12 h after operation. It was revealed by HE staining that there was obvious isehemic damage in the right territory of frontoparietal lobe. All the above changes were not observed in sham operation group. Conclusion The focal cerebral ischemia and reperfusion model in rabbits established by vascular interventional method is micro-invasive, well-controllable, stable and reliable, which is a favorable experimental animal model for research of focal cerebral ischemia and reperfusion.

  10. ACIDENTE OFÍDICO EM EQUINO PORTADOR DE BABESIOSE CLÍNICA RELATO DE CASO

    Directory of Open Access Journals (Sweden)

    Joel de Souza Montello Neto

    2015-12-01

    Full Text Available One horse, snakebite victim and carrier of Babesia caballi, was met with intense dermal hemorrhage in the medial region of the fore and hindlimbs, face, jugular groove and ventral thorax and abdomen, and swelling in the area between the kneecap and the pastern of the left hind limb. Was made support medicine, dressing and bandage on site identified as snake-bite site. The next day, there was a marked decrease in packed cell volume, where it was decided to blood transfusion; After 12 hours the packed cell volume level is 14%, and it increased gradually, reaching 26% in the sixth day of hospitalization. The next day, there was a marked decrease in packed cell volume, where it was decided to blood transfusion; After 12 hours the hematocrit level is 14%, and it increased gradually, reaching 26% in the sixth day of hospitalization. The animal was discharged after 27 days of hospitalization. We conclude that clinical babesiosis was an enhancer factor in anemia in patients. The Synergy hemolytic action of hemoparasite as well as vascular toxic action the venom aggravate circulatory disease of the patient. Um equino vitima de acidente ofídico e portador de Babesia caballi foi atendido apresentando hemorragia dérmica intensa na região medial dos membros torácicos e pélvicos, face, sulco jugular e região ventral do tórax e abdômen, e edema na região compreendida entre a rótula e a quartela do membro pélvico esquerdo. Foi feito medicamento de suporte, curativo e bandagem no local identificado como sítio da picada. No dia seguinte, observou-se diminuição acentuada do volume globular, onde optou-se pela realização de transfusão sanguínea; decorridas 12 horas o volume globular encontrava-se em 14%, e apresentou aumento gradativo, chegando a 26% no sexto dia de internação. O animal obteve alta após 27 dias de internação. Concluímos que a babesiose clínica foi um fator intensificador na anemia apresentada pelo paciente. A sinergia da a

  11. 依达拉奉对脑梗死合并OSAHS患者血管性认知功能影响%Effect of Edaravone on the Cerebral Infarction Patients with Obstructive Sleep Apnea Hypopnea Syndrome with Vascular Cognitive Function

    Institute of Scientific and Technical Information of China (English)

    庞伟; 周琛; 全洁; 陈艳

    2016-01-01

    目的:研究依达拉奉能否改善脑梗死合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血管性认知功能。方法:68例脑梗死合并OSAHS患者,随机分为观察组34例,对照组34例。观察组予依达拉奉治疗10 d,于治疗前后进行神经功能缺失评分,生活自理评分及简易精神状态检查量表(minimum mental state examination,MMSE)评分。观察两组治疗效果,对比结果差异。结果:观察组患者神经功能缺失评分改善,生活自理能力提高,MMSE量表中的定向力、记忆力、注意力和计算力、语言能力及综合总分均较对照组改善,差异均有统计学意义(P (n=34) and the control group(n=34).The observation group received Edaravone for 10 days,before and after the treatment,the scores of neurological function deficits,activities of daily living scale and mini mental state examination table (minimum mental state examination,MMSE) score.Observed the therapeutic effect of the two groups,the differences between the results.Result:Observation groups of patients with neurological functional deficit scores improved,self-care ability,mini mental state examination table of orientation,memory, attention and calculation ability,language ability,comprehensive score were improved compared with control group the differences were statistically significant(P<0.05).Conclusion:Cerebral infarction patients with OSAHS caused by ischemia and hypoxia is the root cause of vascular cognitive impairment.Edaravone can improve the hypoxia caused by vascular injury,reduce the cognitive dysfunction,worthy of clinical popularization and application.

  12. Expression of Interleukin-10 on Cerebral Vascular Endothelial Cells in Smoking Rats%烟草烟雾对大鼠脑血管内皮细胞白细胞介素10表达的影响

    Institute of Scientific and Technical Information of China (English)

    刘菲; 柳宗兰; 王一沙

    2011-01-01

    目的 观察不同吸烟量大鼠脑血管内皮细胞白细胞介素10的表达,探讨烟草烟雾导致脑缺血的发病机制.方法 健康Wistar大鼠60只,分为正常对照组、假暴露组、暴露卷烟烟气30天组、暴露卷烟烟气30天后停止暴露30天组(戒烟组)、暴露卷烟烟气90天高剂量组、暴露卷烟烟气90天低剂量组.通过免疫组织化学法观察大鼠脑血管内皮细胞白细胞介素10的表达.结果 正常对照组和假暴露组白细胞介素10的表达较多,暴露卷烟烟气90天高剂量组白细胞介素10的表达明显低于其他各被动吸烟组,戒烟组白细胞介素10的表达明显高于其他各被动吸烟组,各被动吸烟组白细胞介素10的表达较正常对照组和假暴露组减少(P<0.05).结论 烟草烟雾可致脑血管内皮细胞白细胞介素10的表达减少,可能在缺血性脑血管病的发病中起重要作用.%Aim To observe the expression of interleukin-10 (IL-10) on cerebral vascular endothelial cells in smoking rats, and to discuss the mechanism of ischemia in brain caused by smoking. Methods 60 health Wistar rats were divied into 6 groups: normal control group, sham exposure group, exposed cigarette smoke 30 days group, exposed cigarette smoke 30 days then stopping exposion for 30 days group, exposed cigarette smoke 90 days high dose group and exposed cigarette smoke 90 days low dose group. The expression of IL-10 were observed in smoking rats by immunohistochemistry stain. Results The expression of IL-10 in normal control group and sham exposure group were more. The expression of IL-10 in exposed cigarette smoke 90 days high dose group were significantly lower than those in the other passive smoking groups. The expression of IL-10 in exposed cigarette smoke 30 days then stopping exposure for 30 days group were significantly higher than those in the other passive smoking groups. The expression of IL-10 in the passive smoking groups were significantly lower than

  13. Desigualdades entre pacientes hospitalizados por doenças cardíacas e vasculares-cerebrais em localidade do Estado de São Paulo (Brasil, 1986 Inequalities among patients hospitalized for cardiac and cerebral-vascular diseases in the City of the State of S. Paulo, Brazil, 1986

    Directory of Open Access Journals (Sweden)

    Juan Stuardo Yazlle Rocha

    1989-10-01

    Full Text Available Valendo-se de um sistema de informações sobre hospitalizações no Município de Ribeirão Preto, SP (Brasil foram estudadas as características clínico-epidemiológicas referidas dos pacientes internados, em 1986, por doenças cardíacas e vasculares-cerebrais (DCVC. De 43.499 hospitalizações ocorridas naquele ano, 4.673 foram ocasionadas por doenças cardíacas e vasculares-cerebrais. Utilizando a fonte de financiamento da internação como indicador do estrato social ao qual pertence o paciente, foram compostos 4 grupos de estudo: particulares, "outros", previdenciários e "não pagantes"; estes grupos apresentaram diferenças significativas quanto a coeficiente de internações por DCVC, média e mediana de idade na hospitalização, perfil ocupacional, duração da internação, freqüência dos sub-grupos diagnósticos, coeficientes de mortalidade e a idade média e mediana nos casos de óbitos. Estas diferenças foram atribuídas às disparidades sociais no nível de vida e condições de trabalho dos grupos estudados o que determina diferenças no adoecer, ser assistido e no morrer.The clinical and epidemiological characteristics of hospitalizations due to cardiac and cerebral-vascular diseases (CCVD - ICD 390 - 438, which occurred in 1986, were studied on the basis of data from an information system relating to medical care in the City of Ribeirão Preto, State of S. Paulo, Brazil. These causes accounted for 4,673 of the annual total of 43,449 hospital admissions. Using the sources of payment of the hospitalization as an indicator of the patients' social strata, the following four study groups were defined: private, social insurance, non-paying and "others". These groups showed significant differences in relation to the following variables: hospitalization rates due to CCVD, mean and median age at admission and time of death, occupation, average length of stay in the hospital, mortality rates and relative frequencies of specific

  14. Comparative Study of the Specificities of Needling Acupoints DU20, DU26 and HT7 in Intervening Vascular Dementia in Different Areas in the Brain on the Basis of Scale Assessment and Cerebral Functional Imaging

    Institute of Scientific and Technical Information of China (English)

    HUANG Yong; LAI Xin-sheng; TANG An-wu

    2007-01-01

    Objective: Using methods of clinical scale assessment and cerebral functional imaging to compare the relative specificity of needling acupoints Baihui (DU20), Shuigou (DU26) and Shenmen (HT7) in intervening vascular dementia (VD) in different areas in the brain. Methods: Fifty patients with VD were randomized into 5 groups. Needling on conventionally used acupoints of hand and foot three Yang-meridians aiming at hemiplegia was applied to the patients in Group A, and needling on DU20 to Group B, on DU26 to Group C, on HT7 to Group D and on all the three to Group E was applied additionally. Assessments of Mini Mental State Examination (MMSE), Activities of Daily Living (ADL) and Family Attitude Questionnaire (FAQ) were made. And the positron emission computerized tomography (PET) and single photon emission computerized tomography (SPECT) examinations were conducted in 5 selected patients from each group before and after treatment. Results: Needling on conventional acupoints plus DU20 could effect the inner temporal system, thalamencephalon system and prefrontal cortical system to improve memory and executive capacity of VD patients; conventional acupoints plus DU26 could effect more to the prefrontal cortical system to obviously elevate the executive capacity;that plus HT7 would reveal an effect similar to but rather weaker than plus DU20, and effect more to memory; and that plus all the three simultaneously could effect rather roundly multiple aspects of the nervous system related to intellectual activities, to elevate the recognition and enhance the executive capacity. Conclusion: Needling on various acupoints like DU20, DU26 and HT7 have effects on different brain areas.

  15. Analysis of CTA imaging feature for the neck vascular plagues in elderly patients with senile asymptomatic cerebral infarction%老年无症状脑梗死患者颈部血管斑块CTA影像学特点分析

    Institute of Scientific and Technical Information of China (English)

    赵红英; 杨国涛

    2014-01-01

    Objective Using MDCTA(multi slice spiral CT angiography)analyzed the characteristics of senile asymptomatic cerebral infarction patients with neck vascular plaque and plaque and the relationship between symptoms of cerebral infarction and distribution characteristics. Methods a retrospective analysis of 294 cases of senile cerebral infarction patients without symptoms of head and neck CTA findings and clinical data was done, with comparative analysis on the relationship between parts and the cerebral infarction of different properties of vascular plaques prone. Results The occurrence probability of patients with cerebral infarction of senile asymptomatic neck vascular calcification plaque and non calcified plaque had no statistical significance. Calcified plaque appeared more common in the intracranial segment of internal carotid artery, and non calcified plaques appeared more common in carotid artery. Conclusion The incidence of calcified plaque and non calcified plaques had an important role in asymptomatic cerebral infarction of the elderly.%目的:应用MDCTA(多排螺旋CT血管成像)检查分析老年无症状脑梗死患者颈部血管斑块性质及分布特点以及斑块分布特点与老年无症状脑梗死之间的关系。方法回顾性分析294例老年无症状脑梗死患者头颈部CTA结果和临床资料,比较分析不同性质的血管斑块容易发生的部位与脑梗死之间的关系。结果老年无症状脑梗死患者颈部血管钙化斑块与非钙化斑块发生概率差异无统计学意义,钙化斑块出现在颈内动脉颅内段较多,而非钙化斑块出现在颈总动脉较多。钙化斑块及非钙化斑块均对老年人无症状脑梗死的发病起重要作用。结论老年无症状脑梗死患者积极行头颈部CTA检查可以及时、详尽的了解颈部血管斑块病变,分析患者梗死灶出现的致病机理,对临床治疗起到重要的指导作用。

  16. Diagnóstico clínico diferencial entre oclusão da artéria carótida interna e da artéria cerebral média A comparative symptomatological study of internal carotid artery occlusion and middle cerebral artery occlusion

    Directory of Open Access Journals (Sweden)

    Roberto Melaragno

    1971-03-01

    Full Text Available Foi feito um estudo comparativo entre o quadro clínico inicial de 61 casos de oclusão da artéria carótida interna e o de 23 casos de oclusão da artéria cerebral média, diagnosticados pela angiografia cerebral e/ou pela necropsia em pacientes submetidos ou não à cirurgia vascular. Os autores comparam a idade dos pacientes, o sexo, o modo de início da afecção, a existência ou não de convulsões e/ou cefaléias, a ocorrência do acidente cerebral durante o sono ou em vigília, a existência de ictos prévios, os níveis de pressão arterial, o grau de consciência, a força muscular, os achados eletrencefalográficos, a palpação e ausculta das carótidas em nível cervical. Os resultados são demonstrados em índices percentuais, pelos quais os autores inferem que não há significância estatística nesses elementos com três exceções: a maior ocorrência de convulsões nas oclusões da artéria cerebral média em relação às da carótida, a oftalmodinamometria e a sintomatologia carotídea cervical. A oftalmodinamometria revela valores significantemente menores nas pressões da artéria central da retina, no mesmo lado da trombose da carótida em 70,0% dos casos, enquanto que medidas normais e simétricas verificaram-se em todos os casos de oclusão da artéria cerebral média em que o exame foi realizado. No que concerne a sinais arteriais no pescoço, havia anormalidades palpatórias e auscultatórias em 52,4% dos pacientes com trombose da carótida e em 8,6% dos casos com oclusão da cerebral média. Concluem os autores, portanto, que apenas a angiografia cerebral permite um diagnóstico seguro entre ambas as sedes da oclusão.A comparative study of the early clinical picture in 61 cases of internal carotid artery occlusion and 23 cases of middle cerebral artery occlusion, diagnosed by cerebral angiography and/or necropsy in patients who were either submitted to surgery or not operated upon is reported. The authors had

  17. Vascular imaging findings in 43 patients with cerebral infarction due to spontaneous cerebral artery dissection%43例表现为脑梗死的自发性脑动脉夹层分离的血管影像学表现

    Institute of Scientific and Technical Information of China (English)

    陈红兵; 洪华; 王莹; 刘德志; 殷勤; 刘新峰

    2011-01-01

    合。结论CAD的诊断依赖于血管影像学,诊断的关键在于熟悉其好发部位并发现特征性影像学改变。DSA是诊断CAD的重要手段,而MRA +MRI和CTA及其原始图像亦极具价值,应予重视。应对CAD进行血管影像学随访,为防治策略的调整提供依据。%Objective To investigate the imaging characteristics of spontaneous cerebral artery dissection (CAD) causing cerebral infarction by analyzing the vascular imaging findings.Methods The neuroimaging and clinical data in patients with cerebral infarction due to spontaneous CAD were reviewed. The characteristic findings at different sites of CAD in all vascular imaging examinations were analyzed and summarized. Results A total of 43 patients (28 men, 15women; mean age, 45.1 + 12.3 years) with CAD were included in the study. Twenty-three patients with extracranial internal carotid artery dissection (ICAD), 5 with intracranial anterior circulation dissection, 7 with extracranial vertebral artery dissection (VAD), 6 with intracranial VAD, and 2 with basilar artery dissection (BAD). In patients with extracranial ICAD, occlusion (usually beginning about 1-2 cm above the bifurcation and tapering to a complete occlusion with a flame-like or mouse-tail appearance) was the common imaging findings, luminal stenosis (irregular, elongated, and tapered stenosis) and/or dissecting aneurysms were observed in partial patients, intimal flaps and double-lumen sign were found in a few patients, and vessel tortuosity of ipsilateral or bilateral ICA were observed in 6 patients. Characteristic signs of occlusion or stenosis of extracranial ICAD were observed in computed tomography angiography (CTA) or magnetic resonance angiography (MRA) in partial patients, and magnetic resonance imaging (MRI) could reveal the bright hyperintense crescent-shaped zone that represents the intramural hematoma, and resource imaging of CTA could reveal intimal flaps and double-lumen sign at the level of

  18. Related risk factors for pulmonary infections in cerebral vascular disease patients%脑血管疾病患者合并肺部感染的相关危险因素调查

    Institute of Scientific and Technical Information of China (English)

    黄贞

    2013-01-01

    OBJECTIVE To explore the related risk factors for the pulmonary infections in the patients with cerebral vascular diseases so as to perform the targeted prevention. METHODS The medical records of 176 cases with cerebral vascular diseases were retrospectively analyzed, the related risk factors for the combined pulmonary infections were analyzed as well. RESULTS There were 36 cases with pulmonary infections, and the incidence rate was 20. 46%. The incidence rates of the pulmonary infections were as follows:the people whose age was less than 70 years 11. 98% , the people whose age was more than 70 years 4. 38% , the male 23. 91 % , the female 16. 67% , the people with disorder of consciousness 51. 72%, the people without consciousness disorder 14. 29%, the hemorrhagic patients 31. 96%, the ischemic patients 6. 33%, the people with invasive operation 37. 50%, the people without the invasive operation 10. 71%, the people complicated with diabetes mellitus 60. 00%, the people without complicated diabetes mellitus 10. 64% , the people combined with chronic bronchitis 76. 92%, the people without chronic bronchitis 10. 67%, the people with intracranial hypertension 55. 56%, the people without intracranial hypertension 16. 46% , the people with the bedridden duration less than 10 days 6. 67% ,and the people with the bedridden duration more than 10 days 25. 19%. The difference in the incidence of pulmonary infections between the patients with different age, consciousness disorders, cerebrovascular disease types, invasive operations, diabetes, chronic bronchitis, intracranial hypertension, and bedridden duration was statistically significant(P< 0. 05). Multivariate logistic analysis revealed that the age, impaired consciousness, cerebrovascular disease types, invasive operation, diabetes, chronic bronchitis, and bedridden time were the independent risk factors(P<0. 01). CONCLUSION The incidence rate of the pulmonary infections is relatively high in the patients with the

  19. Vascular cognitive impairment

    Directory of Open Access Journals (Sweden)

    N.V. Vakhnina

    2014-01-01

    Full Text Available Vascular pathology of the brain is the second most common cause of cognitive impairment after Alzheimer's disease. The article describes the modern concepts of etiology, pathogenetic mechanisms, clinical features and approaches to diagnosis and therapy of vascular cognitive impairment (VCI. Cerebrovascular accident, chronic cerebral circulatory insufficiency and their combination, sometimes in combination with a concomitant neurodegenerative process, are shown to be the major types of brain lesions leading to VCI. The clinical presentation of VCI is characterized by the neuropsychological status dominated by impairment of the executive frontal functions (planning, control, attention in combination with focal neurological symptoms. The diagnosis is based on comparing of the revealed neuropsychological and neurological features with neuroimaging data. Neurometabolic, acetylcholinergic, glutamatergic, and other vasoactive drugs and non-pharmacological methods are widely used to treat VCI. 

  20. Tuberculoma cerebral Cerebral tuberculoma

    Directory of Open Access Journals (Sweden)

    ELIZABETH CLARA BARROSO

    2002-01-01

    Full Text Available Relata-se o caso de paciente com crises convulsivas de início recente. A tomografia computadorizada cerebral evidenciou imagem sugestiva de lesão expansiva metastática frontoparietal direita. A investigação de tumor primário ou outra doença foi negativa e o exame histopatológico do tecido cerebral diagnosticou tuberculoma. As convulsões foram controladas com a associação de hidantoína 300mg/dia ao esquema específico, utilizado por 18 meses. A tuberculose do sistema nervoso central representa 5-15% das formas extrapulmonares e é reconhecida como de alta letalidade. Apresentação tumoral como a relatada é rara, particularmente em imunocompetentes. Quando tratada, pode ter bom prognóstico e deve entrar sempre no diagnóstico diferencial de massas cerebrais.It is reported a case of a previously healthy man with seizures of sudden onset. A contrast head computerized tomogram (CT showed a right frontoparietal expanding lesion suggesting to be metastatic. No prior disease was found on investigation. The histologic exam of the brain revealed tuberculoma. The seizures were controlled with Hidantoin 300 mg/day and antituberculosis chemotherapy for 18 months. Central nervous system tuberculosis (5-15% of the extrapulmonary forms is highly lethal. The case reported herein is specially rare in immunocompetent patients. It may have good prognosis and should be considered in the differential diagnosis of brain tumours.

  1. Clinical application of three-dimensional DSA combined with roadmap technique in diagnosis of cerebral vascular diseases%3D-DSA联合roadmap技术在脑血管疾病介入诊治中的应用价值

    Institute of Scientific and Technical Information of China (English)

    陈建华; 贺雄军; 段传志; 刘亚杰; 张炘; 彭志康; 刘亚洪; 汪求精; 何旭英; 黎凯锋

    2015-01-01

    Objective To discuss the application value of three-dimensional digital subtraction angiography(3D-DSA) combined with roadmap technology in diagnosis and therapy for cerebral vascular disease. Methods A total of 169 patients with cerebral vascular disease were enrolled, which included 73 males and 57 females;aged 6-81 years old with mean age of 49.31 years old. All of them were performed by DSA and endovascular treatment, and divided into 2 groups accorded to treatment process. The first group(n=104) received 3D-DSA and 2D-DSA examination which combined with roadmap treatment to identify features of aneurysm, arteriovenous malformations(AVM) and artery stenosis in image exposure of 3D-DSA, and compared results with those of 2D-DSA. The second group (n=65) was received 2D-DSA examination and interventional treatment, which also combined with roadmap treatment to compare with 3D-DSA examination combined roadmap treatment in first group. Results In aneurysmal neck detection rate, the accurate rate of 3D-DSA aneurysm was higher 16.3 %(7/43) than that of 2D-DSA, the exposure of aneurysmal neck was higher 48.2%than that of 2D-DSA. There were significant statistic differences in blood flow pattern of AVM artery and vascular malformation construction(P<0.05). The exposure of intravascular plaque by 3D-DSA was higher 30.7%than that of 2D-DSA, and accurate measurement of blood vessels stenosis of 3D-DSA was higher 42.3%than that of 2D-DSA. In treatment, there was significant statistic difference(P<0.05) in operation time and X-ray exposure time between 3D-DSA combined with roadmap technology and 2D-DSA combined with roadmap technology. And there were significant statistic differences between 3D-DSA and 2D-DSA in roadmap image times, image volume dose and X-ray radiation dosage( P<0.05). Conclusion It is demonstrated that compared with traditional 2D-DSA, the 3D-DSA combined with roadmap techniquein cerebrovascular disease has more important application value in diagnosis and

  2. Effects of Leukoaraiosis on Subsequent Cerebral Vascular Disease and Cognitive Function%脑白质疏松对脑血管事件和认知功能的影响

    Institute of Scientific and Technical Information of China (English)

    李晓晴; 毕齐; 刘喷飓

    2013-01-01

    Objective To determine whether the presence of leukoaraiosis (LA) is a risk factor for subsequent cerebral vascular disease and cognitive impairment. Methods We prospectively examined 253 consecutive outpatients at Department of Neurology of Beijing Anzhen Hospital. The patients were divided into two groups:patients with leukoaraiosis (LA group) and patients without leukoaraiosis (control group). According to the scores, the patients in LA group were divided into mild, moderate and severe groups. Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) (Beijing version) were used to assess the cognitive function. We analyzed clinical data. Patients were then followed up for the development of stroke and cognitive changes. Results In LA group, hypertension and diabetes were more common and there was signiifcant difference between LA and control group (P=0.003 and P=0.004, respectively). The prevalence of cognitive impairment in moderate and severe LA groups was much higher than those in control group (P=0.035 and P=0.019, respectively). The incidences of cerebral infarction in mild, moderate and severe LA group were much higher than those in control group (P=0.019, P=0.024 and P=0.049, respectively). The incidences of cognitive impairment in mild, moderate and severe were much higher than those in control group (P=0.048, P=0.036 and P=0.004, respectively). There was signiifcant difference between LA and control group for the development of cerebral infarction and cognitive impairment. Conclusion The incidence of cerebral infarction and cognitive impairment rose in senile patients with leukoaraiosis.%目的评估脑白质疏松(leukoaraiosis,LA)的危险因素,以及对老年患者后期脑血管事件和认知功能障碍发病率的影响。方法连续入组北京安贞医院神经内科253例门诊患者,分为LA组和对照组,按照LA的严重程度,LA组分为轻度组、中度组、重度组。将简

  3. 浅谈脑血管意外患者院前急救的护理程序%Nursing Procedure for Patients with Cerebral Vascular Accident Pre-hospital Emergency

    Institute of Scientific and Technical Information of China (English)

    潘帅平

    2015-01-01

    Objective Pre-hospital first aid is an important part of the rescue,discussed using the normative nursing program backyard before emergency cerebrovascular accident patients life support aging significantly increased,in improving pre-hospital emergency cerebrovascular accident patients play an important role in the success rate.Methods In pre-hospital first aid cor ect specification using the nursing process,quickly understand the patient's vital signs,to condition assessment in time,and make the necessary life support and safe transport.Results Using the right after the normative nursing program,cerebrovascular accident patients with pre-hospital emergency life support aging significantly increased.Conclusion The ef ect of life support on the life support of patients with cerebral vascular accidents in the pre hospital emergency treatment is significantly improved, and it plays an important role in improving the success rate of cerebrovascular accident patients.%目的院前急救是抢救的重要环节,探讨运用规范的护理程序后院前急救脑血管意外患者生命支持的时效显著提高,在提高脑血管意外患者院前急救成功率中有重要作用。方法在院前急救中正确规范运用护理程序,迅速了解患者的生命体征,对病情做出及时评估,并进行必要的生命支持及安全转运。结果运用正确规范的护理程序后,院前急救脑血管意外患者生命支持的时效显著提高。结论在运用正确规范的护理程序后,院前急救脑血管意外患者生命支持的时效显著提高,在提高脑血管意外患者院前急救成功率中有重要作用。

  4. Cerebral Palsy

    Science.gov (United States)

    ... 1 • 2 • 3 For Teens For Kids For Parents MORE ON THIS TOPIC Cerebral Palsy: Keith's Story Physical Therapy I Have Cerebral Palsy. Can I Babysit? Body Image and Self-Esteem Contact Us Print Resources Send to a friend ...

  5. Culpa da vítima: um modelo para perpetuar a impunidade nos acidentes do trabalho Guilty victims: a model to perpetuate impunity for work-related accidents

    OpenAIRE

    Rodolfo Andrade de Gouveia Vilela; Aparecida Mari Iguti; Ildeberto Muniz Almeida

    2004-01-01

    Neste artigo analisam-se os laudos e dados obtidos das investigações de acidentes graves e fatais do trabalho efetuadas pelo Instituto de Criminalística (IC), Regional de Piracicaba. Foram analisados 71 laudos de acidentes ocorridos em 1998, 1999 e 2000. Os acidentes envolvendo máquinas representam 38,0%, seguido pelas quedas de altura (15,5%) e em terceiro lugar os causados por corrente elétrica (11,3%). Os laudos concluem que 80,0% dos acidentes são causados por "atos inseguros" cometidos p...

  6. Acidentes de trabalho em indústria gráfica

    Directory of Open Access Journals (Sweden)

    João de Barros Barreto

    1947-03-01

    Full Text Available Os autores analisam, dentro do campo da higiene industrial, as condições sanitárias de um grande estabelecimento de artes gráficas no Rio de Janeiro — a Imprensa Nacional, o regime de trabalho aí instituído; e revistam, um a um, os processos industriais executados, especialmente atenção às causas potenciais de acidentes, que aí existem, e também àquelas cuja responsabilidade já se positivou. Ressaltam, no ponto de vista doutrinário, os diversos fatores que podem interferir na ocorrência dêsses infortúnios de trabalho; e, mostrando como tem sido superestimada a culpabilidade das máquinas, realçam a importância dos fatores individuais — idade e experiência do operário, doenças e defeitos físicos, atitude mental, constituição fisio-psicologica. Salientam como a evidência da predisposição a acidentes, que se reconheça existir, possibilita manter os operários, já em função ou pretendentes a emprego, debaixo de supervisão rigorosa; e oportuniza mesmo colocá-los melhormente, em tarefas que, no máximo, só lhes possam acarretar aciden¬tes de natureza leve. Mostram que, no período em estudo — 1942 a 1945, houve ao todo 1.123 acidentes na I.N., com o coeficiente geral de incidência de 220.3 por 1.000 operários expostos. O coeficiente de acidentes médios ou graves foi de 32 por mil, no mesmo período. Apontando ainda a descenção, no quatriênio, das curvas relativas tanto aos acidentes totais, como aos médios ou graves e aos produzidos por máquinas, dão a ver que a taxa, que retrata essa descida, é, para os primeiros, 3.5 e cêrca de 10 vêzes maior, respectivamente, que a dos acidentes por máquinas e dos médios ou graves. Mostra-se significativa a diferença, entre a tendência observada nas curvas dos acidentes em geral e dos médios ou graves; já isso, porém, não acontece, quanto à diferença entre a primeira e a dos acidentes produzidos por máquinas. De fato, sendo os valores de t respec

  7. [Cerebral vascular accidents in French Polynesia].

    Science.gov (United States)

    Gras, C; Papouin, G; Prigent, D; Beaugendre, E; Lionet, P; Brodin, S; Legall, R; Marjou, F; Spiegel, A; Gendron, Y

    1992-01-01

    The authors report on the results of a survey on cardiovascular accidents hospitalized between 01 April 1990 and 31 January 1991 carried out in the Services of Medicine and Cardiology in the Territorial Hospital Center of Papeete. This survey was: 56 cardiovascular accidents: 1/4 (hemorrhagic and 3/4 (42) ischemic. Mean age 59 (extremes 23-86). 36 males (64%); 20 females (36%). 50 Polynesians; 6 Chinese people. Among the risk factors recorded, 38 (68%) were hypertensed patients; 17 (30%) were due to tabagism and 15 (25%) to diabetes; 3 (5%) are known to be carriers of a hypercholesterolemia. 59% of the patients had no case history; 25% the cardiovascular accidents have been observed in patients with cardiopathy; 12.5% are recurrent cardiovascular accidents. Clinically, 5 transient ischemic accidents (12%) out of 42 cardiovascular ischemic accidents. High arterial tension was recognized in 12/14 (86%) of hemorrhagic cardiovascular accidents and in 26/42 (62%) of ischemic cardiovascular accidents. In 42 ischemic cardiovascular accidents, 31 patients suffered from cardiopathy (74%) of which 15 (36%) presented an embolic cardiopathy. Interest of echography and electrocardiogram are discussed. Ultrasonic exam of carotid vessels was found abnormal in almost half of the cases when utilized (12/26). Finally, etiological diagnosis was certain in 17 cases, of presumption in 16 cases, and in 9 cases, it was not possible to precise any cardiovascular etiology. Tomodensitometric tests are discussed. 86% of the ischemic cardiovascular accident were treated with anticoagulants/thrombocyte antiagglutination. 24% of the patients died, 50% recovered incompletely and 26% completely. PMID:1602953

  8. 胰岛素对脑梗死小鼠梗死周围区血管直径和梗死体积的影响%Effects of insulin on vascular diameter of the peri -infarct region and infarct volume after cerebral infarction in mice

    Institute of Scientific and Technical Information of China (English)

    吴腾腾; 李明月; 邝亚晗; 裴中; 陶玉倩

    2016-01-01

    Objective To investigate the effects of insulin on vascular diameter of the peri -infarct region and infarct volume after cerebral infarction in mice. Methods Forty male C57/BL6j mice w ere randomly divided into a control group ( n = 5), a cerebral infarction group ( n = 15), a cerebral insulin resistance group (n = 5), and a cerebral insulin resistance infarction group ( n = 15). A model of cerebral infarction w as induced by the photochemical method. A model of cerebral insulin resistance w as induced by intracerebroventricular injection of streptozocin. Tw o -photon confocal microscope w as used to in vivo evaluate the changes of vascular diameter in the peri-infarct region at 20 min after insulin injection into the cerebelomedulary cistern. After modeling of cerebral infarction, artificial cerebrospinal fluid or insulin (10 ng/ml) w as immediately injected into the cerebelomedulary cistern, and the effect of insulin on cerebral infarct volume w as evaluated at 24 h after infarction. Results Insulin did not have significant effect on various types of cerebral vascular diameters in the normal control group, but it significantly contracted cerebral arteries ( -23.16% ±6.86% and -23.32% ±6.40%, respectively; al P <0.001) and penetrating arteries ( -15.20% ±5.51% and -16.40% ±4.27%, respectively; al P < 0.001) in the cerebral insulin resistance group and the cerebral insulin resistance infarction group, but it did not have any effect on the diameters of the cerebral veins. There w ere no significant differences in the vasoactive effects of insulin betw een the cerebral infarction group and the normal control group, as w el as betw een the cerebral insulin resistance group and the cerebral insulin resistance infarction group. Insulin significantly reduced the volume of cerebral infarction in the cerebral infarction group (9.0 ±1.0 mm3 vs.6.0 ±1.2 mm3; t = 4.294,P =0.002), and it did not have significant effect on the volume of cerebral infarction in the

  9. Clinical study of senile cerebral vascular disease sequelae hyponatremia in elderly%老年脑血管病后遗症患者低钠血症临床研究

    Institute of Scientific and Technical Information of China (English)

    刘莹; 张敏; 李景刚

    2014-01-01

    Objective We aimed to research on the causes of senile cerebrovascular disease sequela patients complicated with hyponatremia, to facilitate the treatment process of the intervention. Method 80 patients with cerebral vascular disease sequelae from January 2012 to December 2013 in our hospital ward neural department of internal medicine were taken as the research objects. In terms of hyponatremia, they were divided into two groups: 32 cases in low sodium group, 48 cases in normal group. The related factors were analyzed. Results The main influence factors of senile cerebrovascular disease sequela patients complicated with hyponatremia is old age, being bedridden, nasal feeding, unconsciousness, combined with tumor, with pneumonia or respiratory failure, incomplete cardiac function in coronary heart disease, poor nutrition. The above factors were representative index (P<0.05). The clinical manifestations were mainly fatigue, anorexia, increase of disturbance of consciousness which accounted for 68.75%, 65.63%, 59.38%respectively, according to the incidences of qualifying are fatigue, anorexia, exacerbation of disturbance of consciousness, weak pulse, nausea, vomiting, cold extremities, dizziness, irritability, delirium and seizures. 32 cases were found in a timely manner. With timely supplement of sodium, 30 patients with hyponatremia were corrected, 2 patients with recurrent hyponatremia finally complicated with multiple organ failure, pulmonary infection were died. Conclusion The figure of elderly patients with cerebral vascular disease sequela of hyponatremia incidence is still high, the causes and severity of sequelae, complications, survival status are closely related, and the clinical manifestations were not specific. As for intervention on high risk factors of high-risk patients, the monitoring is the main means of prevention and treatment.%目的:研究老年脑血管病后遗症患者并发低钠血症的原因,以利于治疗

  10. Prevalência e fatores associados a acidentes de trabalho em zona rural

    Directory of Open Access Journals (Sweden)

    Fehlberg Marta Fernanda

    2001-01-01

    Full Text Available OBJETIVO: Investigar a ocorrência de acidentes do trabalho, na zona rural, e sua associação com alguns fatores de risco. MÉTODOS: O estudo foi realizado na zona rural do município de Pelotas, RS. O delineamento do estudo foi transversal de base populacional. Uma amostra representativa dos trabalhadores rurais foi obtida por meio de amostragem, em estágios múltiplos, utilizando-se os setores censitários da Fundação IBGE. As entrevistas foram realizadas em um período de quatro meses, utilizando-se questionários padronizados e pré-codificados. Os 580 trabalhadores entrevistados pertenciam a 258 famílias da zona rural. RESULTADOS E CONCLUSÕES: A prevalência de acidentes encontrada foi de 11%. Os fatores de risco associados à maior ocorrência de acidentes, na análise multivariada, foram a classe social mais baixa (OR=1,81, a cor não-branca (OR=3,50 e a insatisfação com o trabalho realizado (OR=2,77.

  11. Impact of metabolic syndrome on cardio-cerebral vascular events in pre-hypertensive population%代谢综合征对高血压前期人群心脑血管事件的影响

    Institute of Scientific and Technical Information of China (English)

    吴寿岭; 蔡军; 张颖; 阮春雨; 田琪; 金成; 李金锋; 孙玉艳; 黄卫; 钟吉文

    2012-01-01

    目的 探讨代谢综合征对高血压前期人群心脑血管事件的影响.方法 采用前瞻性队列研究方法,以参加2006年7月至2007年10月健康查体的101 510名开滦集团在职及离退休职工中30 ~70岁的高血压前期者(符合JNC-7诊断标准,29 968例)作为观察队列,并依据中国成人血脂异常防治指南对2004年中华医学会糖尿病学分会建议的修订将其分为代谢综合征阴性组和代谢综合征阳性组.随访38 ~53(47.35 ±4.68)月,随访期间每半年收集1次新发心脑血管事件情况.用Kaplan-Meier法计算代谢综合征阴性组和代谢综合征阳性组心脑血管事件的累积发病率,并用logrank法检验.采用多变量Cox比例风险回归模型分析影响心脑血管事件发生的因素.结果 (1)随访期间,代谢综合征阳性组总心脑血管事件、心肌梗死、脑梗死的累积发病率均高于代谢综合征阴性组,分别为1.80%比1.28%、0.35%比0.29%、1.10%比0.57%,其中总心脑血管事件、脑梗死事件组间差异有统计学意义(P<0.01);(2)校正相关因素后,与代谢综合征阴性组相比,代谢综合征阳性组总心脑血管事件和脑梗死事件的相对危险度(RR)分别为1.45(95%口CI:1.10 ~1.92)、1.84(95% CI:1.27 ~2.67).结论 代谢综合征可增加高血压前期人群发生心脑血管疾病的危险.%Objective This study investigated the impact of metabolic syndrome on the development of cardio-cerebral vascular (CVD) events in a pre-hypertensive population.Methods The data used in this prospective study was derived from the Kailuan study cohort ( n =101 510).Prehypertension was diagnosed in 29 968 (mean age:50 ±9 years and 23 744 males) individuals by the JNC Ⅶ criteria and these subjects were further classified into metabolic syndrome positive ( MS +,n =3447) and MS negative ( MS -,n =26521 ) groups according to the modified 2004 Chinese Diabetes Society criteria.Subjects were followed up

  12. Cerebral palsy.

    Science.gov (United States)

    Graham, H Kerr; Rosenbaum, Peter; Paneth, Nigel; Dan, Bernard; Lin, Jean-Pierre; Damiano, Diane L; Becher, Jules G; Gaebler-Spira, Deborah; Colver, Allan; Reddihough, Dinah S; Crompton, Kylie E; Lieber, Richard L

    2016-01-01

    Cerebral palsy is the most common cause of childhood-onset, lifelong physical disability in most countries, affecting about 1 in 500 neonates with an estimated prevalence of 17 million people worldwide. Cerebral palsy is not a disease entity in the traditional sense but a clinical description of children who share features of a non-progressive brain injury or lesion acquired during the antenatal, perinatal or early postnatal period. The clinical manifestations of cerebral palsy vary greatly in the type of movement disorder, the degree of functional ability and limitation and the affected parts of the body. There is currently no cure, but progress is being made in both the prevention and the amelioration of the brain injury. For example, administration of magnesium sulfate during premature labour and cooling of high-risk infants can reduce the rate and severity of cerebral palsy. Although the disorder affects individuals throughout their lifetime, most cerebral palsy research efforts and management strategies currently focus on the needs of children. Clinical management of children with cerebral palsy is directed towards maximizing function and participation in activities and minimizing the effects of the factors that can make the condition worse, such as epilepsy, feeding challenges, hip dislocation and scoliosis. These management strategies include enhancing neurological function during early development; managing medical co-morbidities, weakness and hypertonia; using rehabilitation technologies to enhance motor function; and preventing secondary musculoskeletal problems. Meeting the needs of people with cerebral palsy in resource-poor settings is particularly challenging. PMID:27188686

  13. CEREBRAL VENOUS THROMBOSIS AND TURNER SYNDROME: A RARE REPORTED ASSOCIATION.

    Science.gov (United States)

    Guler, A; Alpaydin, S; Bademkiran, F; Sirin, H; Celebisoy, N

    2015-01-01

    Turner Syndrome is the only known viable chromosomal monosomy, characterised by the complete or partial absence of an X chromosome. It's the most common chromosomal abnormality in females. Apart from the well known dysmorphic features of the syndrome, it has been associated with a number of vascular pathologies; mainly involving the cardiovascular, renovascular, peripheral vascular and cerebrovascular system. It seems striking that thromboembolism is not considered as a feature of the syndrome. Most of the thromboembolism cases are related to the arterial vascular system; except for some rare reported portal venous thrombosis cases, peripheral venous thrombosis cases and to the best of our knowledge a single case of cerebral venous thrombosis with Dandy Walker malformation and polymicrogyria. We herein report a cerebral venous thrombosis case with Turner Syndrome. With no other found underlying etiology, we want to highlight that Turner Syndrome, itself, may have a relationship not only with the cerebral arterial vascular system pathologies but also with the cerebral venous thrombosis.

  14. Detecting cerebral vascular diseases by transcranial Doppler ultrasound and dolor Doppler flow imaging in comparison with digital subtracted angiography%经颅多普勒及彩色多普勒超声与数字减影脑血管造影对脑血管病检测的比较研究

    Institute of Scientific and Technical Information of China (English)

    张小征; 吕健; 李俊; 胡军民; 龚杰; 徐国政; 马廉亭; 陈欣林

    2000-01-01

    目的 评价经颅多普勒(TCD)在脑血管病诊断、疗效评估中的应用价值.方法 应用TCD检测脑血管疾病患者306例,其中脑动静脉畸形170例,颈动脉海绵窦瘘(CCF)69例,颅内动脉瘤67例,并与数字减影脑血管造影(DSA)、彩色多普勒血流显像(CDFI)进行对比研究.结果 以DSA脑血管造影为金指标,TCD检出脑动静脉畸形93%,检出CCF 100%,判断CCF静脉回流方式96%,检出颅内动脉瘤67%.对颅内较大动脉瘤(>1.5 cm)的检测有特征性表现,提出"动脉瘤样频谱"的新概念.结论 TCD能实时、准确反映颅内血流动力学改变及侧支循环代偿情况,对脑血管病诊断、疗效评估有重要价值.%Objective To evaluate the effect of transcranial Doppler(TCD)on detecting cerebral vascular diseases.Methods One hundred and seventy patients with cerebral arterovenous malformation(AVM),69 carotid cavernous fistula (CCF)and 67 intracranial aneurysms were examined early or late by TCD, digital subtracted angiography(DSA)and color Dopplor flow imaging.The results of their examination were compared and analyzed.Results If the results of DSA examination was regarded as a golden criterion of diagnosing the cerebral vascular dNease,93%of the 170 patients with AVMs,100% of the 69 patients with CCFS and 67%of the 67 patients with the aneurysms were detected by TCD respectively.It was found that the relative larger aneurysm(diameter>1.5 crn)had a special TCD manifestation, the SO-called ”aneurysm-like spectrum”. Conclusion TCD is necessary for detecting the cerebral vascular lesions because it can reveal accurately a change in the intracranial hemodynamics and a condition of the collateral circulation.

  15. Análise dos acidentes de trânsito ocorridos em uma Capital do Nordeste Brasileiro, em 2006.

    Directory of Open Access Journals (Sweden)

    Francisco José de Paula Júnior

    2013-06-01

    Full Text Available Este trabalho teve como objetivo descrever os acidentes de trânsito ocorridos na cidade de Fortaleza, capital do Ceará, no ano de 2006. Foi realizado um estudo descritivo, transversal, a partir de dados do Sistema de Informação de Acidentes de Trânsito de Fortaleza, que agrega todas as informações pertinentes aos acidentes de trânsito ocorridos na capital cearense, além de informações do Sistema de Informações Hospitalares. Esses dados foram analisados utilizando o software EPI INFO®. Em 2006, foram registrados 23.443 acidentes de trânsito. Desses, houve uma proporção de 2:1, entre homens e mulheres e os óbitos ocorreram principalmente na faixa etária de 30 a 59 anos, liderados por pedestres 141 (41,34% e motociclistas com 76 (22,28%. Entre os tipos de acidentes 14.267 (60,85% registraram-se colisões, tendo o mês de dezembro e o intervalo de 18 às 20 horas apresentado o maior número de registros. Em relação aos ferimentos, os motociclistas foram os mais lesionados, atingindo 5.634 (40,57% pessoas. Parte significativa dos acidentes e óbitos envolveu adolescentes e adultos jovens, resultando em 341 (0,71% vitimas que evoluíram para óbito. É fundamental estimular políticas públicas para melhoria nas condições de trânsito e um maior investimento para os sistemas que coletam informações sobre os acidentes.

  16. The guiding significance of the 640 layer CT perfusion combined with the vascular imaging in thrombolysis therapy for the super acute cerebral in-farction%640层CT灌注联合血管成像在脑梗死超早期溶栓中的指导意义

    Institute of Scientific and Technical Information of China (English)

    田峰; 田学实; 梁文胜

    2014-01-01

    Objective To investigate the guiding significance of 640 layer CT perfusion combined with vascular ima-ging in thrombolytic therapy for super acute cerebral infarction .Methods 30 cases of patients with superacute cere-bral infarction were taken the examination of brain CT scan and 640 CT layer perfusion combined with the vascular im-aging.The ischemic penumbra were determined according to the change of cerebral blood flow (CBF),regional cere-bral blood volume (rCBV),mean traverse time(MTT)and time to peak(TTP)in region of interest(ROI)and the ratio of left and right sides of CBF .At the same time ,38 patients were chosen to give thrombolytic therapy without CT perfu-sion imaging (20 patients with arterial thrombolytic therapy and 18 patients with intravenous thrombolytic therapy ) . Compare their discrepancy in efficacy .Results The effect of arteriovenous thrombolytic therapy guided by CT perfu-sion is better than that of non perfusion guidance of arteriovenous thrombolytic therapy .Conclusion It has a guid-ing significance in thrombolytic therapy for super acute cerebral infarction to make 640 CT perfusion combined with vascular imaging ,which can show that the degree of head and neck vascular stenosis and determine ischemic penumbra for guiding early clinical interventional thrombolytic therapy or vascular reconstruction treatment in order to save ische -mic penumbra and restore the blood perfusion of ischemic brain tissue as soon as possible .It has crucial clinical value to improve the prognosis and reduce the incidence of mortality and morbidity .%目的:探讨640层CT灌注联合血管成像在脑梗死超早期溶栓中的指导意义。方法对30例脑梗死超早期的患者,进行脑部CT平扫及640层CT灌注联合血管成像检查,根据脑血流量( CBF )、脑血容量、平均通过时间、达峰时间的变化及左右两侧CBF的比值,判定有无缺血半暗带;同时选择未做CT灌注检查的38例溶栓患者,对比它

  17. Vascular CTA Imaging in the Early Diagnosis and Determine the Cause of the Value of Clinical Application of Cerebral Hemorrhage%血管CTA成像技术在脑出血早期诊断及其病因判断中的临床应用价值

    Institute of Scientific and Technical Information of China (English)

    廖文彬

    2015-01-01

    Objective To investigate the multi slice spiral CT angiography (MSCTA) in the application value in the early diagnosis of cerebral hemorrhage. Methods Through spiral CT plain scan in 45 cases of patients, cerebral hemorrhage patients for clinical diagnosis, the results of whole brain angiography diagnosis result is compared with the DSA method. Results In 45 cases of cerebral hemorrhage patients, were examined by MSCTA on it, found that 29 patients with cerebral aneurysm, 9 patients with arteriovenous malformation, 2 cases of patients with moyamoya disease, 3 patients with venous vascular malformation, 2 cases of patients with unexplained. Pathological detection of cerebral aneurysm in 30 cases, SCTA showed aneurysm in 29, the detection rate was 96.67%, 4 cases of patients with tumors located in the intracranial segment of internal carotid artery in 9 patients, the tumors located in the anterior communicating artery, 4 cases of patients with tumors located in the anterior cerebral artery, 3 cases of patients with tumor in the vertebral basilar artery, 9 patients with tumor in the brain artery. Conclusion Vascular CTA imaging technique is a safe, no brain vascular imaging invasive, reliable and can be used as the preferred method for early diagnosis of cerebral hemorrhage.%目的:探讨多层螺旋CT血管成像技术(MSCTA)在脑出血早期诊断的应用价值。方法通过对患者进行螺旋CT平扫,对45例脑出血患者进行临床诊断,将诊断的结果与DSA全脑动脉造影检查结果进行比较。结果在45例脑出血患者中,通过对其进行MSCTA检查,结果发现29例患者为脑动脉瘤,9例患者为动静脉畸型,2例患者为烟雾病,3例患者为静脉性血管畸型,2例患者原因不明。病理检出脑动脉瘤30例,SCTA显示动脉瘤29,检出率为96.67%,4例患者肿瘤位于颈内动脉颅内段、9例患者肿瘤位于前交通动脉、4例患者肿瘤位于大脑前动脉、3例患

  18. [Vascular dementia

    NARCIS (Netherlands)

    Leeuw, H.F. de; Gijn, J. van

    2004-01-01

    Vascular dementia is one of the most frequently occurring dementia syndromes. Its prevalence is about 5% among subjects above 85 years of age. Elevated blood pressure and atherosclerosis are the most important risk factors. According to international criteria, vascular dementia usually occurs within

  19. Acidente ofídico no estado de Goiás

    Directory of Open Access Journals (Sweden)

    Pinho Fábia Maria Oliveira

    2004-01-01

    Full Text Available OBJETIVO: Avaliar aspectos epidemiológicos dos acidentes por serpentes peçonhentas ocorridos no Estado de Goiás. MÉTODOS: Foram analisadas ''Fichas de investigação de acidentes por animais peçonhentos'', pertencentes ao sistema de notificação da Secretaria de Saúde do Estado de Goiás, no triênio 1998-2000. RESULTADOS: Foram notificados, neste período, 3.261 acidentes por serpentes peçonhentas, com coeficiente de incidência variando entre 20 e 23/100.000 habitantes. O maior número de casos ocorreu entre os meses de outubro e abril. Dentre os 2.350 casos em que houve referência ao gênero da serpente, 78,6% foram causados por Bothrops, 20,8% por Crotalus e 6% por Micrurus. Houve predominância do sexo masculino (78,5% e com faixa etária entre 20 e 39 anos de idade. As regiões anatômicas mais freqüentemente picadas foram: pé (43,6%, pernas (23,2% e mãos (20,1%. Em relação ao tempo de atendimento, mais de 80% dos envenenamentos foram atendidos com menos de 6 horas da picada. Os envenenamentos foram classificados, de acordo com a gravidade, em leves (31,6%, moderados (47,5% ou graves (9,6%. As complicações mais comuns foram necrose tecidual no local da picada (31,8% nos envenenamentos botrópicos e insuficiência renal aguda (1,2% nos envenenamentos crotálicos. A letalidade geral foi de 0,46%, sendo a maior taxa observada entre acidentes crotálicos (1%. CONCLUSÕES: Acidentes por serpentes peçonhentas no Estado de Goiás acometem principalmente a população jovem do sexo masculino e têm sido causa de óbito.

  20. [Insomnia and cerebral hypoperfusion].

    Science.gov (United States)

    Káposzta, Zoltán; Rácz, Klára

    2007-11-18

    Insomnia is defined as difficulty with the initiation, maintenance, duration, or quality of sleep that results in the impairment of daytime functioning, despite adequate opportunity and circumstances for sleep. In most countries approximately every third inhabitant has insomnia. Insomnia can be classified as primary and secondary. The pathogenesis of primary insomnia is unknown, but available evidence suggests a state of hyperarousal. Insomnia secondary to other causes is more common than primary insomnia. Cerebral hypoperfusion can be the cause of insomnia in some cases. In such patients the cerebral blood flow should be improved using parenteral vascular therapy. If insomnia persists despite treatment, then therapy for primary insomnia should be instituted using benzodiazepine-receptor agonists such as Zolpidem, Zopiclone, or Zaleplon. In those cases Midazolam cannot be used for the treatment of insomnia due to its marked negative effect on cerebral blood flow. In Hungary there is a need to organize multidisciplinary Insomnia Clinics because insomnia is more than a disease, it is a public health problem in this century. PMID:17988972

  1. Cerebral oxygenation and hyperthermia

    Directory of Open Access Journals (Sweden)

    Anthony Richard Bain

    2014-03-01

    Full Text Available Hyperthermia is associated with marked reductions in cerebral blood flow (CBF. Increased distribution of cardiac output to the periphery, increases in alveolar ventilation and resultant hypocapnia each contribute to the fall in CBF during passive hyperthermia; however, their relative contribution remains a point of contention, and probably depends on the experimental condition (e.g. posture and degree of hyperthermia. The hyperthermia-induced hyperventilatory response reduces arterial CO2 pressure (PaCO2 causing cerebral vasoconstriction and subsequent reductions in flow. During supine passive hyperthermia, the majority of recent data indicate that reductions in PaCO2 may be the primary, if not sole, culprit for reduced CBF. On the other hand, during more dynamic conditions (e.g. hemorrhage or orthostatic challenges, an inability to appropriately decrease peripheral vascular conductance presents a condition whereby adequate cerebral perfusion pressure may be compromised secondary to reductions in systemic blood pressure. Although studies have reported maintenance of pre-frontal cortex oxygenation (assessed by near-infrared spectroscopy during exercise and severe heat stress, the influence of cutaneous blood flow is known to contaminate this measure. This review discusses the governing mechanisms associated with changes in CBF and oxygenation during moderate to severe (i.e. 1.0°C to 2.0°C increase in body core temperature levels of hyperthermia. Future research directions are provided.

  2. Cerebral hypoxia

    Science.gov (United States)

    ... the veins ( deep vein thrombosis ) Lung infections (pneumonia) Malnutrition When to Contact a Medical Professional Cerebral hypoxia ... References Bernat JL. Coma, vegetative state, and brain death. In: Goldman L, Schafer AI, eds. Goldman's Cecil ...

  3. Human cerebral circulation. Positron emission tomography studies

    International Nuclear Information System (INIS)

    We reviewed the literature on human cerebral circulation and oxygen metabolism, as measured by positron emission tomography (PET), with respect to normal values and of regulation of cerebral circulation. A multicenter study in Japan showed that between-center variations in cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) values were not considerably larger than the corresponding within-center variations. Overall mean±SD values in cerebral cortical regions of normal human subjects were as follows: CBF=44.4±6.5 ml/100 ml/min; CBV=3.8±0.7 ml/100 ml; OEF=0.44±0.06; CMRO2=3.3±0.5 ml/100 ml/min (11 PET centers, 70 subjects). Intrinsic regulation of cerebral circulation involves several factors. Autoregulation maintains CBF in response to changes in cerebral perfusion pressure; chemical factors such as PaCO2 affect cerebral vascular tone and alter CBF; changes in neural activity cause changes in cerebral energy metabolism and CBF; neurogenic control of CBF occurs by sympathetic innervation. Regional differences in vascular response to changes in PaCO2 have been reported, indicating regional differences in cerebral vascular tone. Relations between CBF and CBV during changes in PaCO2 and during changes in neural activity were in good agreement with Poiseuille's law. The mechanisms of vascular response to neural activation and deactivation were independent on those of responses to PaCO2 changes. CBV in a brain region is the sum of three components: arterial, capillary and venous blood volumes. It has been reported that the arterial blood volume fraction is approximately 30% in humans and that changes in human CBV during changes in PaCO2 are caused by changes in arterial blood volume without changes in venous blood volume. These findings should be considered in future studies of the pathophysiology of cerebrovascular diseases. (author) 136 refs

  4. OCORRÊNCIA DE ACIDENTES COM MATERIAS PERFUROCORTANTES COM ENFERMEIROS NO AMBIENTE HOSPITALAR

    Directory of Open Access Journals (Sweden)

    PEREIRA, J.M.D.A.

    2015-09-01

    Full Text Available Segundo a Organização Internacional do Trabalho (OIT, cerca de 2,2 milhões pessoas morrem anualmente em ocorrência de acidentes e doenças de origem profissional, os quais geralmente são causados pelo não uso de equipamento de proteção individual (EPI, desobediência a normas e procedimentos; negligência profissional, imprudência pessoal e, terceirização de serviços. Neste contexto destacamos os enfermeiros, pois desempenham um trabalho de assistência direta e contínua ao paciente, tornando-se susceptível a contaminação por material biológico, principalmente em acidentes por inoculação percutânea mediada por agulhas ou instrumentos cortantes, que são os maiores responsáveis pela transmissão ocupacional de infecções sanguíneas. A prevenção de acidentes de trabalho deve ser uma preocupação tanto pelos profissionais quanto pelas instituições hospitalares. Os profissionais devem ser conscientes em relação à necessidade de conhecer e empregar adequadamente as normas de biossegurança e exigir segurança no ambiente hospitalar aos seus empregadores para o exercício assistencial com menor risco para a saúde ocupacional. Isto é de fundamental importância, uma vez que os profissionais de saúde e principalmente os de enfermagem, se opõem a utilização de equipamentos de proteção individual, subestimando o risco de se infectarem. Diante da frequência da ocorrência de acidentes de trabalho ocasionados por material perfuro cortante, que podem ser observados na atuação do enfermeiro, deve-se preocupar com implementação de práticas que lhe oferecem condições seguras para o desempenho de suas atividades laborais. Esta pesquisa terá como objetivo identificar o índice de acidentes com materiais perfurocortantes com enfermeiros nos diversos setores do hospital. Trata-se de um estudo retrospectivo descritivo, com abordagem quantitativa dos dados, no qual tem por finalidade se basear em dados de acidentes

  5. Cerebral autoregulation dynamics in endurance-trained individuals

    NARCIS (Netherlands)

    M. Lind-Holst; J.D. Cotter; J.W. Helge; R. Boushel; H. Augustesen; J.J. van Lieshout; F.C. Pott

    2011-01-01

    Aerobic fitness may be associated with reduced orthostatic tolerance. To investigate whether trained individuals have less effective regulation of cerebral vascular resistance, we studied the middle cerebral artery (MCA) mean blood velocity (V(mean)) response to a sudden drop in mean arterial pressu

  6. Cerebral Paragonimiasis.

    Science.gov (United States)

    Miyazaki, I

    1975-01-01

    The first case of cerebral paragonimiasis was reported by Otani in Japan in 1887. This was nine years after Kerbert's discovery of the fluke in the lungs of Bengal tigers and seven years after a human pulmonary infection by the fluke was demonstrated by Baelz and Manson. The first case was a 26-year-old man who had been suffering from cough and hemosputum for one year. The patient developed convulsive seizures with subsequent coma and died. The postmortem examination showed cystic lesions in the right frontal and occipital lobes. An adult fluke was found in the occipital lesion and another was seen in a gross specimen of normal brain tissue around the affected occipital lobe. Two years after Otani's discovery, at autopsy a 29-year-old man with a history of Jacksonian seizure was reported as having cerebral paragonimiasis. Some time later, however, it was confirmed that the case was actually cerebral schistosomiasis japonica. Subsequently, cases of cerebral paragonimiasis were reported. However, the majority of these cases were not confirmed histologically. It was pointed out that some of these early cases were probably not Paragonimus infection. After World War II, reviews as well as case reports were published. Recently, investigations have been reported from Korea, with a clinicla study on 62 cases of cerebral paragonimiasis seen at the Neurology Department of the National Medical Center, Seoul, between 1958 and 1964. In 1971 Higashi described a statistical study on 105 cases of cerebral paragonimiasis that had been treated surgically in Japan.

  7. Hipertensão intracraniana em vítimas fatais de acidente de trânsito Increased intracranial pressure in victims of fatal road traffic accident

    Directory of Open Access Journals (Sweden)

    JOSÉ EYMARD HOMEM PITTELLA

    1999-09-01

    Full Text Available Foi realizada análise morfológica, macro e microscópica, das lesões encefálicas de 120 vítimas fatais de acidente de trânsito. A hérnia para-hipocampal, a hemorragia de Duret e o infarto médio-basal occipital, indicadores fidedignos de que o paciente apresentou hipertensão intracraniana (HIC, ocorreram em 43 pacientes (35,8%. A HIC no trauma cranioencefálico é causada pela tumefação cerebral congestiva e pelos hematomas intracranianos. Na presente casuística foram observados 3 hematomas extradurais (7,0%, 9 hematomas subdurais agudos (20,9%, 6 hematomas intracerebrais (14%, 6 explosões lobares (14% e 9 tumefações cerebrais congestivas (20,9%.A morphological study, macro and microscopical, was made of brain lesions in 120 victims of fatal road traffic accidents. Parahipoccampal hernia, Duret haemorrhage and infarction in the medio-basal occipital lobe, clear evidence of raised intracranial pressure, occurred in 43 (35.8% patients. The increased intracranial pressure from the head injury is caused by brain swelling and by intracranial haematomas. In this series 3 cases of extradural haematomas (7.0%, 9 of subdural haematomas (20.9%, 6 of intracerebral haematomas (14%, 6 of burst lobe (14% and 9 of brain swelling (20.9% were observed.

  8. Effects of Xingnaojing Injection on the Expression of Vascular endothelial Growth Factor in Patients with Acute Cerebral Infarction%醒脑静注射液对急性脑梗死患者血清VEGF表达的影响

    Institute of Scientific and Technical Information of China (English)

    张晓玲; 翟丽萍; 官俏兵; 杜瑛媛; 钱淑霞

    2012-01-01

      目的:观察醒脑静注射液对急性脑梗死患者血清血管内皮生长因子(VEGF)表达的影响.方法:65例急性脑梗死患者随机分为醒脑静注射液治疗组33例和对照组32例,另设立正常对照组60例.两组急性脑梗死患者均给予常规抗血小板、他汀类药物治疗,治疗组在此基础上加用醒脑静注射液20mL加入生理盐水250mL中静滴,1天1次,14天为1个疗程.采用双抗体夹心酶联免疫吸附法(ELISA)动态测定两组患者发病第1、3、7、14天时血清VEGF浓度.同时记录入院时和治疗14天的脑梗死灶体积,并进行神经功能缺损评分(NIHSS).结果:与正常对照组比较,65例患者中风后1、3、7、14天各时间点的血清VEGF浓度均明显增高,差异有统计学意义(P0.05).结论:醒脑静注射液能促进急性脑梗死后血清VEGF的表达,参与新生血管形成,提高临床疗效.%  Objective: To explore the effects of Xingnaojing injection on the expression of vascular endothelial growth factor (VEGF) in patients with acute cerebral infarction (ACI). Methods: Sixty-five patients with ACI were randomly divided into Xingnaojing treatment group (experimental group, n=33) and routine treatment group(n=32). Both groups were treated with anti-platelet aggregation and stating, and patients in the experimental group were given additional Xingnaojing injection (20mL/250mL saline, vd, qd) for 14 days. Serum concentrations of VEGF were measured by double antibody sandwich ELISA on day 1,3,7 and 14 after the onset of stroke. Vol⁃umes of infarction and scores of national institutes of health stroke scale(NIHSS)were recorded on admission and on day 14. Other 60 healthy individuals served as blank controls. Results: Compared with the blank control group, the serum concentrations of VEGF in patients with ACI on day 1,3,7 and 14 were obviously increased (P0.05). Conclusion: Xingnaojing injection can promote the production of VEGF and participate in

  9. Cerebral palsy - resources

    Science.gov (United States)

    Resources - cerebral palsy ... The following organizations are good resources for information on cerebral palsy : National Institute of Neurological Disorders and Stroke -- www.ninds.nih.gov/disorders/cerebral_palsy/cerebral_palsy. ...

  10. Cerebral Palsy (For Parents)

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Cerebral Palsy KidsHealth > For Parents > Cerebral Palsy Print A A ... kids who are living with the condition. About Cerebral Palsy Cerebral palsy is one of the most common ...

  11. Lesion-symptom mapping in vascular cognitive impairment

    NARCIS (Netherlands)

    Biesbroek, J.M.

    2016-01-01

    Cerebral vascular disease (CVD) is an important cause of cognitive decline and dementia, either alone or in combination with neurodegenerative diseases, such as Alzheimer's Disease (AD). The contribution of CVD to cognitive decline and dementia is referred to as Vascular Cognitive Impairment (VCI).

  12. Chronic administration of isocarbophos induces vascular cognitive impairment in rats.

    Science.gov (United States)

    Li, Peng; Yin, Ya-Ling; Zhu, Mo-Li; Pan, Guo-Pin; Zhao, Fan-Rong; Lu, Jun-Xiu; Liu, Zhan; Wang, Shuang-Xi; Hu, Chang-Ping

    2016-04-01

    Vascular dementia, being the most severe form of vascular cognitive impairment (VCI), is caused by cerebrovascular disease. Whether organophosphorus causes VCI remains unknown. Isocarbophos (0.5 mg/kg per 2 days) was intragastrically administrated to rats for 16 weeks. The structure and function of cerebral arteries were assayed. The learning and memory were evaluated by serial tests of step-down, step-through and morris water maze. Long-term administration of isocarbophos reduced the hippocampal acetylcholinesterase (AChE) activity and acetylcholine (ACh) content but did not alter the plasma AChE activity, and significantly damaged the functions of learning and memory. Moreover, isocarbophos remarkably induced endothelial dysfunction in the middle cerebral artery and the expressions of ICAM-1 and VCAM-1 in the posterior cerebral artery. Morphological analysis by light microscopy and electron microscopy indicated disruptions of the hippocampus and vascular wall in the cerebral arteries from isocarbophos-treated rats. Treatment of isocarbophos injured primary neuronal and astroglial cells isolated from rats. Correlation analysis demonstrated that there was a high correlation between vascular function of cerebral artery and hippocampal AChE activity or ACh content in rats. In conclusion, chronic administration of isocarbophos induces impairments of memory and learning, which is possibly related to cerebral vascular dysfunction. PMID:26818681

  13. Epidemiologia do acidente por serpentes peçonhentas: estudo de casos atendidos em 1988

    Directory of Open Access Journals (Sweden)

    Lindioneza Adriano Ribeiro

    1995-10-01

    Full Text Available Foram avaliados aspectos epidemiológicos de acidentes por serpentes peçonhentas no Estado de São Paulo, Brasil, com base em prontuários de 322 pacientes e em entrevistas feitas com 209 deles e/ou seus acompanhantes. Os acidentes ocorreram principalmente com pessoas de 10 a 20 anos de idade, do sexo masculino, nos meses de outubro a abril e no período diurno. As regiões anatômicas mais freqüentemente picadas foram os pés, as mãos e as pernas. Bothrops, Crotalus e Micrurus foram responsáveis por, respectivamente, 95,0%, 4,4% e 0,6% dos casos. Não ocorreram óbitos, mas 2,2% dos pacientes apresentaram seqüelas. Dentre os 209 entrevistados, a ocupação de lavrador foi a mais freqüentemente relacionada ao acidente que, em aproximadamente 60% das vezes, ocorreu durante o trabalho. O total de 160 pacientes (76,6% submeteram-se a alguma forma de tratamento antes de chegarem a um serviço de saúde: foram mais comuns o uso de torniquete (50,2%, a expressão local na tentativa de retirar parte do veneno (33,5%, a colocação das mais diversas substâncias sobre o local da picada (36,8% e a ingestão de outras (12,9%; pouco mais de um quarto dos pacientes submeteram-se a alguma forma de tratamento médico antes de chegar ao HVB sendo mais comum a antissepsia (8,2%, a administração do antiveneno (6,2%, de anti-histamínicos (5,7% e de analgésicos (5,3%.

  14. Epidemiologia do acidente por serpentes peçonhentas: estudo de casos atendidos em 1988

    Directory of Open Access Journals (Sweden)

    Ribeiro Lindioneza Adriano

    1995-01-01

    Full Text Available Foram avaliados aspectos epidemiológicos de acidentes por serpentes peçonhentas no Estado de São Paulo, Brasil, com base em prontuários de 322 pacientes e em entrevistas feitas com 209 deles e/ou seus acompanhantes. Os acidentes ocorreram principalmente com pessoas de 10 a 20 anos de idade, do sexo masculino, nos meses de outubro a abril e no período diurno. As regiões anatômicas mais freqüentemente picadas foram os pés, as mãos e as pernas. Bothrops, Crotalus e Micrurus foram responsáveis por, respectivamente, 95,0%, 4,4% e 0,6% dos casos. Não ocorreram óbitos, mas 2,2% dos pacientes apresentaram seqüelas. Dentre os 209 entrevistados, a ocupação de lavrador foi a mais freqüentemente relacionada ao acidente que, em aproximadamente 60% das vezes, ocorreu durante o trabalho. O total de 160 pacientes (76,6% submeteram-se a alguma forma de tratamento antes de chegarem a um serviço de saúde: foram mais comuns o uso de torniquete (50,2%, a expressão local na tentativa de retirar parte do veneno (33,5%, a colocação das mais diversas substâncias sobre o local da picada (36,8% e a ingestão de outras (12,9%; pouco mais de um quarto dos pacientes submeteram-se a alguma forma de tratamento médico antes de chegar ao HVB sendo mais comum a antissepsia (8,2%, a administração do antiveneno (6,2%, de anti-histamínicos (5,7% e de analgésicos (5,3%.

  15. Acidentes de transporte terrestre em município da Região Sul do Brasil

    OpenAIRE

    Andrade Selma Maffei de; Mello Jorge Maria Helena P. de

    2001-01-01

    Foram estudadas as características dos acidentes de transporte terrestre, com 3.643 vítimas, ocorridos no primeiro semestre de 1996, em Londrina, PR. O tipo de acidente mais freqüente foi a colisão com carro/caminhonete. A frota de motocicletas foi a que gerou a maior taxa de vítimas (cerca de sete vezes a apresentada por carros/caminhonetes). Maior risco de óbito foi evidenciado entre motociclistas que colidiram com objeto fixo (letalidade de 29,4%), seguido por pedestres atropelados por cam...

  16. Tuberculoma cerebral

    OpenAIRE

    BARROSO ELIZABETH CLARA; OLIVEIRA TÂNIA REGINA BRÍGIDO DE; AMARAL ANA MARIA DANTAS DO; PINHEIRO VALÉRIA GÓES FERREIRA; SOUSA ANA LÚCIA DE OLIVEIRA

    2002-01-01

    Relata-se o caso de paciente com crises convulsivas de início recente. A tomografia computadorizada cerebral evidenciou imagem sugestiva de lesão expansiva metastática frontoparietal direita. A investigação de tumor primário ou outra doença foi negativa e o exame histopatológico do tecido cerebral diagnosticou tuberculoma. As convulsões foram controladas com a associação de hidantoína 300mg/dia ao esquema específico, utilizado por 18 meses. A tuberculose do sistema nervoso central representa ...

  17. Acidente de trabalho, morte e fatalismo Work accident, death and fatalism

    Directory of Open Access Journals (Sweden)

    Izabel Cristina Ferreira Borsoi

    2005-04-01

    Full Text Available Este artigo se propõe discutir a atitude fatalista diante do acidente de trabalho e da morte. Toma como suporte empírico a representação que trabalhadores acidentados na construção civil constroem acerca daqueles eventos. Parte de um conjunto de entrevistas com seis trabalhadores que se encontravam afastados do trabalho por invalidez decorrente do acidente. A análise realizada busca mostrar que os indivíduos tendem a construir explicações e justificativas a partir de uma perspectiva fatalista de modo a poderem aceitar e conviver com o medo do acidente e da morte ou com a dor da perda. Argumenta também que a atitude fatalista, não pode se modificar apenas com a tomada de consciência, por parte dos trabalhadores, de que acidentes e mortes no trabalho estão relacionados a condições precárias de trabalho. Para modificarem suas atitudes, seria necessário, também, que experimentassem novas condições de vida e trabalho, podendo, assim, construir uma nova concepção de mundo e de vida.This article proposes a discussion about the fatalistic posture adopted when a worker faces work accidents and death. It has its empirical support on the representation which injured construction workers create about these events. The study was based on interviews made with six workers who were unable to return to work due to the disability caused by accidents. The accomplished analysis intends to show that the individuals create explanations and justifications based on a fatalistic perspective. This way of thinking enables them to accept and to live with the fear of accidents and death, or with the pain caused by a loss. It also argues that the fatalistic attitude cannot be modified only by understanding that accidents and deaths that happen at the work environment are related to its precarious conditions. In order to change this attitude, it would be necessary to experience new conditions of life and work, so that the workers would be able to create

  18. OCORRÊNCIA DE ACIDENTES COM MATERIAS PERFUROCORTANTES COM ENFERMEIROS NO AMBIENTE HOSPITALAR

    OpenAIRE

    PEREIRA, J.M.D.A.; GAMA, N.B.; RICARDO,E.V.

    2015-01-01

    Segundo a Organização Internacional do Trabalho (OIT), cerca de 2,2 milhões pessoas morrem anualmente em ocorrência de acidentes e doenças de origem profissional, os quais geralmente são causados pelo não uso de equipamento de proteção individual (EPI), desobediência a normas e procedimentos; negligência profissional, imprudência pessoal e, terceirização de serviços. Neste contexto destacamos os enfermeiros, pois desempenham um trabalho de assistência direta e contínua ao paciente...

  19. CT Perfusion and MR Perfusion Weighted Imaging in Evaluating the Effect of Vascular Reconstruction on Short-term Cerebral Blood Flow in Patients with Moyamoya Disease%CT灌注与MR灌注加权成像评价烟雾病血管重建术对烟雾病患者短期脑血流的影响

    Institute of Scientific and Technical Information of China (English)

    崔若棣; 易明岗

    2015-01-01

    Objective To study CT perfusion (CTP) and MR perfusion (PWI) weighted imaging in evaluating the effect of vascular reconstruction on short-term cerebral blood flow in patients with moyamoya disease.Methods 47 patients with unilateral vascular reconstruction confirmed by DSA in the hospital were selected as the research objects and all received vascular reconstruction. All the patients received CTP and PWI examination before and after operation to obtain parameters, such as cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP). The preoperative and postoperative distribution of cerebral middle artery (MCA) and ipsilateral cerebellar perfusion parameters in control part (rCBF, rCBV, rMTT and rTTP) were compared as well as the differences in preoperative and postoperative relative value of CTP and PWI perfusion parameters.Results Postoperative CT perfusion image showed that CBF, CBV, MTT and TTP in the right distribution area of MCA significantly changed, compared with those before operation. Postoperative PWI perfusion image showed that CBF, CBV, MTT and TTP significantly significantly changed, compared with those before operation. After operation, rCBF and rCBV values in the distribution area of operation side MCA and the control ares were significantly higher than those before operation (P<0.05) while rMTT and rTTP were significantly lower than those before operation (P<0.05).Conclusion Both of CT perfusion and MR perfusion weighted imaging are the effective observation methods to observe the changes of cerebral blood flow in patients with moyamoya disease, which can be used in clinic.%目的:研究CT灌注(CTP)与MR灌注(PWI)加权成像评价烟雾病血管重建术对烟雾病患者短期脑血流的影响。方法选取我院47例经DSA证实的单侧血管重建术患者为研究对象,均行血管重建术治疗,术前术后接受CTP、PWI检查,获得脑血容量(CBV)、脑血流量(CBF)、平均通

  20. The effect of herbs on cerebral energy metabolism in cerebral ischemia-reperfusion mice

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Vascular dementia is one of the most familiar types of senile dementia. Over the past few years, the research on the damage of cerebral tissues after ischemia has become a focus. The factors and mechanism of cerebral tissue damage after ischemia are very complex. The handicap of energy metabolism is regarded as the beginning factor which leads to the damage of neurons, but its dynamic changes in ischemic area and its role during the process of neuronal damage are not very clear. There are few civil reports on using 31 P nuclear magnetic resonance instrument to explore the changes of cerebral energy metabolism in intravital animals. After exploring the influence of herbs on cerebral energy metabolism in ischemia-reperfusion mice, we came to the conclusion that herbs can improve the cerebral energy metabolism in ischemia-reperfusion mice.

  1. Vascular potassium channels in NVC.

    Science.gov (United States)

    Yamada, K

    2016-01-01

    It has long been proposed that the external potassium ion ([K(+)]0) works as a potent vasodilator in the dynamic regulation of local cerebral blood flow. Astrocytes may play a central role for producing K(+) outflow possibly through calcium-activated potassium channels on the end feet, responding to a rise in the intracellular Ca(2+) concentration, which might well reflect local neuronal activity. A mild elevation of [K(+)]0 in the end feet/vascular smooth muscle space could activate Na(+)/K(+)-ATPase concomitant with inwardly rectifying potassium (Kir) channels in vascular smooth muscle cells, leading to a hyperpolarization of vascular smooth muscle and relaxation of smooth muscle actin-positive vessels. Also proposed notion is endothelial calcium-activated potassium channels and/or inwardly rectifying potassium channel-mediated hyperpolarization of vascular smooth muscle. A larger elevation of [K(+)]0, which may occur pathophysiologically in such as spreading depression or stroke, can trigger a depolarization of vascular smooth muscle cells and vasoconstriction instead. PMID:27130411

  2. Short-term prognosis for speech and language in first stroke patients Prognóstico em curto prazo para fala e linguagem em pacientes acometidos de infarto cerebral único

    Directory of Open Access Journals (Sweden)

    Fabricio F. Oliveira

    2009-09-01

    Full Text Available OBJECTIVE: To evaluate the factors that can influence evolution of communication after a first stroke. METHOD: Thirty-seven adult patients were evaluated for speech and language within 72 hours after a single first-ever ischemic brain injury and later on. Patients who were comatose, with decompensated systemic diseases, or history of chronic alcoholism or illicit drug use were not included. Brain CT and/or 2T-MR exams were solicited for topographic correlation. Size of infarct was classified as large or small according to the TOAST classification. RESULTS: Patients who survived had lesser chances of presenting with aphasia or dysarthria 3 months after the stroke if the infarct size was small (p=0.017. Gender, age, schooling, aphasia subtype, infarct side and topography were non-significant in our sample. Subjects with global aphasia or lone cortical dysarthria had a slower evolution. CONCLUSION: Brain injury size was the most influential factor for neurological outcome at 3 months post-stroke.OBJETIVO: Avaliar os fatores que podem influenciar o desempenho neurolinguístico após um primeiro acidente vascular cerebral isquêmico. MÉTODO: Foram avaliados 37 pacientes quanto a fala e linguagem dentro de 72 horas após um primeiro infarto cerebral e posteriormente. Pacientes comatosos, com doenças sistêmicas descompensadas, história de etilismo crônico ou uso de drogas ilícitas não foram incluídos. TC e/ou RMN-2T cerebrais foram solicitadas para correlação topográfica. Utilizou-se a classificação TOAST para o tamanho do infarto (grande ou pequeno. RESULTADOS: Sobreviventes tiveram menores chances de apresentarem-se afásicos ou disártricos 3 meses após o evento agudo caso o infarto fosse pequeno (p=0.017. Gênero, idade, escolaridade, subtipo de afasia, lado e topografia da lesão cerebral não foram fatores estatisticamente significativos. Pacientes portadores de afasia global ou disartria cortical isolada evoluíram mais lentamente

  3. Multiparametric multidetector computed tomography scanning on suspicion of hyperacute ischemic stroke: validating a standardized protocol Avaliação multiparamétrica por tomografia computadorizada multidetectores na suspeita de isquemia cerebral hiperaguda: validando um protocolo padronizado

    Directory of Open Access Journals (Sweden)

    Felipe Torres Pacheco

    2013-06-01

    âmicas. O presente protocolo é adequado como um roteiro reprodutível para a análise da TCMD de pacientes com suspeita de acidente vascular cerebral isquêmico.

  4. Acidentes de trabalho com material biológico ocorridos em municípios de Minas Gerais

    Directory of Open Access Journals (Sweden)

    Renata Siqueira Julio

    2014-01-01

    Full Text Available O objetivo do estudo foi identificar o perfil dos acidentes com exposição a material biológico ocorridos em Minas Gerais. Estudo descritivo, transversal realizado por meio de consulta ao Sistema de Informação de Agravos de Notificação de 50 municípios do sul do Estado de Minas Gerais, Brasil, no período de 2007-2011. Foram registrados 460 acidentes, sendo que cerca da metade ocorreram entre auxiliares e técnicos de enfermagem, seguidos por enfermeiros e médicos. Houve predomínio dos acidentes ocorridos devido ao descarte inadequado de material perfurocortante. Entre os pacientes-fonte, verificou-se uma prevalência de 8,0% de sorologia reagente para o HIV; 1,0% para HBsAg; 6,0% para anti-HBC e 3% para o anti-HCV. Entre os acidentados, 14,0% não estavam imunizados para hepatite B, contudo, a prescrição de vacina e imunoglobulina foi inferior à necessidade. Os resultados subsidiarão o planejamento de ações preventivas e de novas condutas diante da ocorrência desse tipo de acidentes.

  5. Vascular emergencies.

    Science.gov (United States)

    Semashko, D C

    1997-01-01

    This article reviews the initial assessment and emergent management of several common as well as uncommon vascular emergencies. Aortic dissection, aneurysms, and arterial occlusive disease are familiar but challenging clinical entities. Less frequently encountered conditions are also discussed including an aortic enteric fistula, mesenteric venous thrombosis, phlegmasia alba dolens, and subclavian vein thrombosis.

  6. ATENDIMENTO AOS PROFISSIONAÍS VÍTIMAS DE ACIDENTE COM MATERIAL BIOLÓGICO EM UM HOSPITAL DE DOENÇAS INFECTOCONTAGIOSAS

    OpenAIRE

    Lillian Kelly de Oliveira Lopes; Anaclara Ferreira Veiga Tipple; Sirlene Neves Damando; Cássia Silva Miranda; Ivete Vieira Gomes

    2004-01-01

    O risco ocupacional biológico para os trabalhadores da saúde é um assunto muito discutido nas últimas décadas. Entretanto, os registros dos acidentes com material biológico ocorridos nas unidades de saúde não retratam a real situação. O objetivo deste estudo foi identificar o número de atendimento para acidente profissional com material biológico em um hospital de doenças infectocontagiososas e a origem dos encaminhamentos. Os dados foram obtidos por meio dos prontuários dos acidentes pro...

  7. 强化护理干预在高血压病合并脑血管意外后急性昏迷患者中的应用%Application of strengthening nursing intervention on acute coma patients with hypertension combined cerebral vascular accident

    Institute of Scientific and Technical Information of China (English)

    毛云霞

    2015-01-01

    目的:探讨强化护理干预在高血压病合并脑血管意外后急性昏迷患者护理中的应用效果。方法于2013年4月—2014年4月选取102例高血压病合并脑血管意外后急性昏迷患者,根据入院时间分为对照组50例和观察组52例,其中对照组采用常规急救与护理方法,观察组在对照组基础上采用强化护理干预。比较两组治疗结局、护理相关性并发症发生率和护理满意度的差异。结果两组治愈率、残疾率、植物生存率和病死率比较差异无统计学意义(P >0.05)。观察组感染、应激性溃疡、脑水肿、脑疝和下肢深静脉血栓等护理相关并发症发生率均低于对照组,护理满意率高于对照组,差异均有统计学意义(P <0.05)。结论严密观察病情,有效的强化护理干预措施有助于降低高血压病合并脑血管意外患者的护理相关并发症发生率,提高护理质量。%Objective To investigate the influence of strengthening nursing intervention on acute coma patients with hypertension combined cerebral vascular accident. Methods From April 2013 to April 2014,a total of 102 acute coma patients with hypertension combined cerebral vascular accident,were divided into the control group(n = 50),which were given the conventional treatment and nursing methods,and the observation group(n = 52),which were given the strengthening nursing intervention. The effects and nursing related complications rate were compared. Results The rates of cure,morbidity,mortality and plants survival of two groups had no significant differences( P > 0. 05). Nursing complication of infection,pressure ulcer,brain edema,cerebral hernia and low extremity deep vein thrombosis of the observation group were significantly lower than those of the control group(P < 0. 05). The nursing satisfaction rate between two groups was significantly different(P < 0. 05). The nursing satisfaction of the observation group was

  8. Revisão bibliográfica sobre acidentes com crianças Bibliography review about children' accidents

    Directory of Open Access Journals (Sweden)

    Luiza Jane Eyre Xavier de Souza

    1999-06-01

    Full Text Available RESUMO O objetivo do estudo consistiu em apresentar uma revisão bibliográfica dos acidentes com crianças. Utilizaram-se as pesquisas documental e bibliográfica como metodologia. Os dados evidenciam que o acidente com criança é um dos maiores problemas de saúde pública na Inglaterra. Nos Estados Unidos aconteceram, em 1989, cerca de 2.700 mortes como resultado de acidentes em crianças abaixo de 11 anos. No Brasil, também registram-se elevados índices de atendimentos envolvendo os acidentes domésticos e, em Fortaleza, no Ceará, esses casos também são identificados. Conclui-se que os acidentes com crianças são alarmantes e merecem atenção específica com uma abordagem preventiva.ABSTRACT The study's proposal was to evidence a. bibliography review about children' accidents. The bibliography and documental researches were used as methodology. The data made clear that children accidents are the bigger public health problem in. England. In the United States, in 1989, had happened about 2.700 deaths as accident results in children under 1.1 years old. In. Brazil has been registered high index of attendance at pediatric emergencies that involves home accidents. It has been concluded that these cases have been increasing and they need special attention and preventive approach.

  9. 伴脑血管病的晚发型Pompe病一家系临床、病理和分子遗传学特点%Clinical, pathological and molecular genetic studies on a pedigree with late-onset Pompe's disease complicated with cerebral vascular diseases

    Institute of Scientific and Technical Information of China (English)

    赵玉英; 赵冰; 杨霞峰; 孙义华; 李伟; 焉传祝

    2012-01-01

    目的 报道1个以脑血管病为主要临床表现的晚发型Pompe病家系,总结其临床、病理和分子遗传学特点.方法 对1个伴脑血管病的兄妹共患病晚发型Pompe病家系进行家系调查和临床、病理资料收集;5名家系成员均行酸性α-糖苷酶(GAA)基因目的片段PCR扩增与测序.结果 患病者为兄妹2人,均有自青少年期出现的进行性肢带肌无力,近来出现眩晕、共济失调等症状方就诊,颅脑CT和MRI示梗死、出血和脑白质多发缺血变性灶,其中哥哥颅脑CT血管成像(CTA)示脑动脉多处狭窄与后循环系统多发动脉瘤,妹妹颅脑CTA仅显示有多处动脉串珠样狭窄.前者肌肉活体组织检查病理表现为典型的空泡样变性和肌纤维内糖原的沉积.2例患者GAA酶活性均明显低于正常.对该家系5位家族成员(包括2例患者)的GAA基因分析发现2例患者及其母亲存在第9号外显子自1388位点起19个碱基的杂合缺失突变.结论 以后循环受累为主的脑血管病是Pompe病少见的特殊表型.GAA基因c.1388 del 19为新发突变,与临床表型的关系尚不能确定.%Objective To report a pedigree with late-onset Pompe' s disease complicated with cerebral vascular diseases as to summarize their clinical,pathological and molecular genetic characteristics.Methods We investigated the clinical and pathological data of the two affected siblings with late-onset Pompe' s disease complicated with cerebral vascular diseases.All the 5 members of this pedigree accepted the GAA gene analysis.Results Both affected siblings had progressive pelvic girdle muscle weakness from young adult age,and recently developed vertigo and ataxia.Brain imaging of them revealed multiple cerebral hemorrhage,infarction and diffuse ischemic white matter lesions.The brother had multiple aneurysms and stenoses of cerebral arteries revealed by brain CTA.However,his sister was only found to have multi-beaded stenoses of cerebral arteries

  10. What Is Vascular Disease?

    Science.gov (United States)

    ... our CEO Board of Directors Scientific Advisory Board History of Vascular Cures Impact Contact Us Vascular Disease What is Vascular Disease? Education and Awareness Vascular Diseases Abdominal Aortic Aneurysm Aortic ...

  11. Diabetes and Vascular Disease

    Science.gov (United States)

    ... our CEO Board of Directors Scientific Advisory Board History of Vascular Cures Impact Contact Us Vascular Disease What is Vascular Disease? Education and Awareness Vascular Diseases Abdominal Aortic Aneurysm Aortic ...

  12. Employees with Cerebral Palsy

    Science.gov (United States)

    ... Resources Home | Accommodation and Compliance Series: Employees with Cerebral Palsy (CP) By Eddie Whidden, MA Preface Introduction Information ... SOAR) at http://AskJAN.org/soar. Information about Cerebral Palsy (CP) What is CP? Cerebral palsy is a ...

  13. Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria

    DEFF Research Database (Denmark)

    Dellavalle, Brian; Staalsoe, Trine; Kurtzhals, Jørgen Anders;

    2013-01-01

    Cerebral malaria (CM) is a potentially fatal cerebrovascular disease of complex pathogenesis caused by Plasmodium falciparum. Hydrogen sulfide (HS) is a physiological gas, similar to nitric oxide and carbon monoxide, involved in cellular metabolism, vascular tension, inflammation, and cell death...

  14. 贝前列素联合维生素E治疗2型糖尿病合并下肢血管病变对防止心脑血管疾病发生的研究%Research on the prevention of cardio-cerebral vascular diseases to beraprost combined with Vitamin E in the treatment of type 2 diabetes mellitus with lower limb vascular diseases

    Institute of Scientific and Technical Information of China (English)

    黄文权; 陈俏洁; 陈聪

    2014-01-01

    目的:探讨贝前列素联合维生素E对心脑血管疾病的预防效果,为贝前列素和维生素E的使用提供理论依据。方法把2型糖尿病合并下肢血管病变患者随机分为实验组(95例)和对照组(86例),实验组的治疗方案采用贝前列素联合维生素E,而对照组采用阿司匹林肠溶片联合维生素E。时间从患者接受治疗算起,1年和2年后回访,统计两组患者发生心血管疾病、致死性心血管疾病、卒中、致死性卒中的情况,采用x2检验分析相关数据。结果1年和2年后发生心脑血管疾病和心血管疾病在实验组与对照组间的差异均有统计学意义(P<0.05)。结论在治疗2型糖尿病合并下肢血管病时,采用贝前列素联合维生素E较阿司匹林肠溶片联合维生素E更能预防心脑血管疾病的发生。%ObjectiveTo investigate the combinatory preventing effect of beraprost and Vitamin E against cardio-cerebral vascular diseases, thus providing a theory base for the usage of these two drugs.Methods Type 2 diabetes mellitus patients with lower limb vascular lesion were randomly divided into experimental group (EG, 95 cases) and control group (CG, 86 cases). EG was treated by the combination of beraprost and Vitamin E, and CG by the combination of aspirin enteric-coated tablets and Vitamin E. The 1 year and 2 year incidence of cardiovascular disease, fatal cardiovascular disease, stroke, fatal stroke in two groups were recorded since the initiation of treatment. Data was analyzed with chi-square test. ResultsThere were statistical difference in incidence of cardio-cerebro-vascular diseases and cardiovascular diseases between the experimental and control groups after 1 year and 2 year (P<0.05).Conclusion In the treatment of type 2 diabetes mellitus patients with lower limb vascular lesion, the preventing effect of combination of beraprost and Vitamin against ecardio-cerebro-vascular diseases is better than

  15. Role of BKCa channels in diabetic vascular complications

    Institute of Scientific and Technical Information of China (English)

    Qian Lingling; Liu Xiaoyu; Wang Ruxing

    2014-01-01

    Objective This review focuses on the role of the large conductance calcium-activated potassium (BKCa) channels in diabetic vascular complications.Data sources Relevant articles published in English or Chinese from 1981 to present were selected from PubMed.The search terms were "BKCa channels" and "diabetes".Important references from selected articles were also retrieved.Study selection Articles regarding the role of BKCa channels in diabetic vascular complications and relevant mechanisms were selected.Results The BKCa channels are abundantly expressed in vascular smooth cells and play an important role in regulation of vascular tone.Multiple studies indicated that the expression and function of BKCa channels are altered by different mechanisms in diabetic vascular diseases such as coronary arterial disease,cerebral arterial disease,and diabetic retinopathy.Conclusion BKCa channels may play an important role in diabetic vascular complications and may be an effective therapeutic target for relieving and reducing the burden of diabetic vascular complications.

  16. The Correlation Study on Intracranial Vascular Stenosis and Transient Ischemic Attack Were Converted to Cerebral Infarction Within One Week%颅内血管狭窄与短暂性脑缺血发作1周内转化为脑梗死的相关性研究

    Institute of Scientific and Technical Information of China (English)

    严庆吉; 刘明会

    2015-01-01

    Objective To discuss influencing factors of intracranial vascular stenosis and transient ischemic attack were converted to cerebral infarction within one week. Methods Retrospective analysis on the clinical data of the 113 patients admitted in our hospital with transient ischemic attack was made. According to the cases whether they had cerebral infraction within one week, these patients were divided into attack group and non-attack group. Using Pearson univariate to analyze the clinical relevant factors and the relationship between them respectively, and for statistically significant factors in single factor analysis, multivariate logistic regression analysis was used. Results Results Pearson univariate analysis showed that age, intracranial vascular stenosis, history of hypertension, history of diabetes, history of coronary heart disease, cerebrovascular disease, etc. are effects of the risk factors of transient ischemic attack was converted to cerebral infarction within one week (P<0.05). Multivariate logistic regression analysis were made to the above mentioned factors, and suggestive hints were that intracranial vascular stenosis, hypertension history, diabetes history, history of coronary heart disease, cerebrovascular disease, etc. belonging to independent risk factors of transient ischemic attack converted to cerebral infarction within one week (P<0.05). Conclusion Intracranial vascular stenosis, hypertension history, diabetes history, history of coronary heart disease, cerebrovascular disease, etc. were risk factors of transient ischemic attack converted to cerebral infarction within one week. For patients with the history of the above mentioned disease, early intervention should be given to avoid the occurrence of transient cerebral ischemia.%目的:探讨颅内血管狭窄与短暂性脑缺血发作1周内转化为脑梗死的影响因素。方法对该院收住的113例短暂性脑缺血发作患者进行临床资料回顾性分析

  17. Análise epidemiológica dos acidentes com material biológicos em um hospital oftalmológico

    Directory of Open Access Journals (Sweden)

    Eduardo Nery Rossi Camilo

    2015-10-01

    Full Text Available RESUMO Objetivo: Analisar a ocorrência e as características dos acidentes com material biológico em um hospital oftalmológico no nordeste do Brasil. Métodos: Estudo transversal, com análise retrospectiva dos dados dos pacientes, realizada por meio de um levantamento dos acidentes com material biológico notificados à Comunicação de Acidentes de Trabalho (CAT durante o período de 2010 a 2013. Resultados: Foram notificados 34 acidentes, sendo 26 (76,5% em trabalhadores do gênero feminino e 8 (23,5% masculino. A média de idade foi 30,0 ± 5,9 anos. Quarenta e oito (82,3% acidentes aconteceram no bloco cirúrgico da sede do hospital, 15 (44,1% foram com auxiliares/técnicos de enfermagem, 8 (23,5% com instrumentadores, 5 (14,7% com médicos em treinamento, 4 (11,8% com médicos formados e 2 (5,9% com equipe de profissionais de limpeza. Os acidentes foram do tipo percutâneo em 30 (88,2% casos e por contato com mucosa em 4 (11,7%. Em 28 (82,4% casos o acidente foi no membro superior, 4 (11,8% na face e 2 (5,9% em membros inferiores. O acidente ocorreu durante o ato cirúrgico em 12 (35,3% e 10 (29,4% durante a manipulação do material após o procedimento cirúrgico. Os acidentes aconteceram com funcionários que possuíam média de dois anos de experiência e após 5,5 horas trabalhadas. Conclusão: Os acidentes com material biológico em um hospital oftalmológico foram mais frequentes em profissionais auxiliares/técnicos de enfermagem, durante o ato cirúrgico e manipulação do instrumental após cirurgia. Este trabalho, portanto, demonstrou a importância de identificar riscos de acidentes laborais entre profissionais de saúde na área de oftalmologia.

  18. Cerebral palsy

    International Nuclear Information System (INIS)

    This paper reviews cranial MR findings in patients with cerebral palsy (CP) to clarify and categorize this disorder. The MR images of 40 patients with clinical CP were retrospectively reviewed. All patients suffered either varying spastic plegias, hypotonicity, or choreoathetosis. Concomitantly, the patients suffered from static encephalopathy, developmental delay, and/or microcephaly. Twenty-four patients were born at or near term, 10 were premature, and incomplete birth histories were available in six. The MR images revealed mild to severe degrees of white matter damage in 24 patients (12 term, nine premature, three unknown)

  19. Acidentes naturais: o paradoxo entre adversidades e potencialidades na gestão urbana

    Directory of Open Access Journals (Sweden)

    Clovis Ultramari

    2015-01-01

    Full Text Available Este artigo busca identificar potencialidades meio a situações de desastres natu - rais em áreas urbanas. É crescente o debate sobre acidentes naturais e seus im - pactos; porém é restrita à busca estratégica de instrumentos transformadores paradoxalmente disponibilizados quando dessas adversidades. A discussão teórico-referencial é seguida de estudo de caso sobre eventos adversos na Região Metropolitana de Curitiba e Região Serrana do Rio de Janeiro, Brasil. Os resul - tados da pesquisa ainda serão submetidos a outras realidades, porém, já se arrisca confirmar a hipótese: em situações adversas, potencialidades podem ser observadas e, talvez pelo paradoxo que suscitam, são pouco apropriadas pelo gestor urbano.

  20. Cerebral malaria.

    Science.gov (United States)

    Postels, Douglas G; Birbeck, Gretchen L

    2013-01-01

    Malaria, the most significant parasitic disease of man, kills approximately one million people per year. Half of these deaths occur in those with cerebral malaria (CM). The World Health Organization (WHO) defines CM as an otherwise unexplained coma in a patient with malarial parasitemia. Worldwide, CM occurs primarily in African children and Asian adults, with the vast majority (greater than 90%) of cases occurring in children 5 years old or younger in sub-Saharan Africa. The pathophysiology of the disease is complex and involves infected erythrocyte sequestration, cerebral inflammation, and breakdown of the blood-brain barrier. A recently characterized malarial retinopathy is visual evidence of Plasmodium falciparum's pathophysiological processes occurring in the affected patient. Treatment consists of supportive care and antimalarial administration. Thus far, adjuvant therapies have not been shown to improve mortality rates or neurological outcomes in children with CM. For those who survive CM, residual neurological abnormalities are common. Epilepsy, cognitive impairment, behavioral disorders, and gross neurological deficits which include motor, sensory, and language impairments are frequent sequelae. Primary prevention strategies, including bed nets, vaccine development, and chemoprophylaxis, are in varied states of development and implementation. Continuing efforts to find successful primary prevention options and strategies to decrease neurological sequelae are needed. PMID:23829902

  1. Comprometimento respiratório secundário a acidente ofídico crotálico (Crotalus durissus Respiratory abnormalities following Crotalus durissus snakebite

    Directory of Open Access Journals (Sweden)

    Carlos Faria Santos Amaral

    1991-08-01

    Full Text Available São analisados três pacientes que apresentaram comprometimento da função respiratória após acidente por Crotalus durissus. As manifestações respiratórias surgiram nas primeiras 48 horas após a picada do ofídio e consistiram de dispnéia, taquipnéia, uso da musculatura acessória da respiração (casos 1 e 2 e batimento das aletas nasais (caso 2. Dois pacientes (casos 1 e 2 apresentaram insuficiência respiratória aguda. O diagnóstico desta complicação no caso 1 foi clínico pois o paciente apresentou apnéia. O paciente do caso 2, 24 horas após o acidente ofídico apresentou dificuldade respiratória intensa e períodos de apnéia sendo intubado, permanecendo em respiração espontânea. Houve agravamento dos sinais clínicos de insuficiência respiratória e a determinação de pH e gases do sangue arterial mostrou em relação ao exame inicial elevação da pressão parcial de gás carbônico (40 mmHg para 50,3 mm Hg caracterizando insuficiência ventilatória aguda. Ambos foram tratados com emprego de ventilação artificial mecânica, tendo o paciente do caso 1 permanecido no ventilador durante 33 dias e o do caso 2 durante 15 dias. Ambos desenvolveram insuficiência renal aguda, necessitaram de diálise peritoneal e recuperaram a função renal. A paciente do caso 3, apesar dos sintomas e sinais de comprometimento respiratório não apresentou alterações do pH e gases arteriais. Espirometria realizada 58 horas após o acidente mostrou capacidade vital forçada (CVF e volume espirado no primeiro segundo (VEF1 abaixo do previsto (60 e 67% respectivamente. As espirometrias realizadas nos dias subseqüentes evidenciaram melhora progressiva destes parâmetros. No 10º dia após o acidente constatou-se aumento de 20% da CVF e de 17% do VEF1 comparativamente ao exame inicial. A relação entre VEF1 e a CVF manteve-se praticamente inalterada e em valores próximos ao previsto, caracterizando distúrbio ventilatório do tipo

  2. Aneurisma de artéria cerebral em criança com síndrome da imunodeficiência adquirida: relato de caso Cerebral arterial aneurysm in a child with acquired immunodeficiency syndrome: case report

    Directory of Open Access Journals (Sweden)

    Arnolfo de Carvalho Neto

    2001-06-01

    Full Text Available A dilatação aneurismática dos vasos do polígono de Willis é manifestação incomum da infecção pelo vírus da imunodeficiência adquirida (HIV, tendo sido relatados, até o momento, 15 casos na literatura. O presente estudo tem por objetivo relatar um novo caso dessa apresentação rara, além de revisar aspectos importantes relacionados à mesma. Um paciente, do sexo masculino, 6 anos de idade, com síndrome da imunodeficiência adquirida (AIDS de transmissão perinatal e tetraparesia, desenvolveu sintomas caracterizados por episódios de crises distônicas. A tomografia computadorizada de crânio, que inicialmente era normal, mostrou dilatação aneurismática dos vasos do polígono de Willis. A revisão de literatura demonstra que os principais achados patológicos em casos similares, são, principalmente, fibrose de camada média com destruição da lâmina interna e hiperplasia da íntima. A etiologia da vasculite não é conhecida, acreditando-se que o vírus da varicela-zoster e o próprio HIV possam estar relacionados à mesma. Conclui-se que, apesar de incomum, tal complicação apresenta grande importância pelo fato dos aneurismas colocarem esses pacientes em grupo de alto risco para acidentes vasculares. A sobrevida relatada na literatura é de menos de 6 meses após o diagnóstico da arteriopatia aneurismática cerebral.Cerebral aneurysmal arteriopathy of the circle of Willis is an uncommon manifestation of acquired human immunodeficiency virus (HIV infection and up to now only 15 cases have been published in the literature. For this reason we add our experience of this rare case, and review the most important aspects related to this entity. The patient is a 6 year old male with perinatal transmitted AIDS, tetraparethic, developed symptoms characterized by episodes of dystonic postures. The computed tomography of the brain showed aneurismal arteriopathy of the circle of Willis. He had a previous normal examination. The review

  3. Neuroradiological findings in vascular dementia

    Energy Technology Data Exchange (ETDEWEB)

    Guermazi, Ali; Miaux, Yves; Suhy, Joyce; Pauls, Jon; Lopez, Ria [Synarc, Inc., Department of Radiology Services, San Francisco, CA (United States); Rovira-Canellas, Alex [Hospital General Universitari Vall d' Hebron, Unita de Resonancia Magnetica, Barcelona (Spain); Posner, Holly [Eisai, Inc., Teaneck, NJ (United States)

    2007-01-15

    There are multiple diagnostic criteria for vascular dementia (VaD) that may define different populations. Utilizing the criteria of the National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN) has provided improved consistency in the diagnosis of VaD. The criteria include a table listing brain imaging lesions associated with VaD. The different neuroradiological aspects of the criteria are reviewed based on the imaging data from an ongoing large-scale clinical trial testing a new treatment for VaD. The NINDS-AIREN criteria were applied by a centralized imaging rater to determine eligibility for enrollment in 1,202 patients using brain CT or MRI. Based on the above data set, the neuroradiological features that are associated with VaD and that can result from cerebral small-vessel disease with extensive leukoencephalopathy or lacunae (basal ganglia or frontal white matter), or may be the consequence of single strategically located infarcts or multiple infarcts in large-vessel territories, are illustrated. These features may also be the consequence of global cerebral hypoperfusion, intracerebral hemorrhage, or other mechanisms such as genetically determined arteriopathies. Neuroimaging confirmation of cerebrovascular disease in VaD provides information about the topography and severity of vascular lesions. Neuroimaging may also assist with the differential diagnosis of dementia associated with normal pressure hydrocephalus, chronic subdural hematoma, arteriovenous malformation or tumoral diseases. (orig.)

  4. Contribution of the cerebral SPECT in the field of evaluation of the hemodynamic cerebral vascular accident risk in the Limb shaking syndrome; Apport de la TEMP cerebrale dans le cadre de l'evaluation du risque d'AVC hemodynamique dans le Limb Shaking Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Lauer, V.; Wolff, V.; Marescaux, C. [CHU de Strasbourg, Unite neurovasculaire, service de neurologie, 67 (France); Namer, I.J. [CHU de Strasbourg, service de biophysique et medecine nucleaire, 67 -Strasbourg (France)

    2010-07-01

    The limb shaking syndrome (L.S.S.) is characterized by uncontrollable shaking of members that are caused by a passage in the upright or by an hyper extension of the neck and occur in a patient with internal carotid stenosis. To investigate the pathophysiology of L.S.S. we used brain SPECT (SPECT-E.C.D. or H.M.P.A.O.) to measure cerebral perfusion in the supine position and standing in three patients. (N.C.)

  5. Study on expression of PKC in vascular smooth muscle of rats with middle cerebral artery occlusion and interfering effect of electro-acupuncture at Shuigou%大脑中动脉梗塞大鼠大脑中动脉蛋白激酶C表达及电针水沟穴干预的研究

    Institute of Scientific and Technical Information of China (English)

    吕艳; 杜元灏; 徐彦龙; 高靓; 崔景军; 杨丽红; 何娇君; 李晶

    2013-01-01

    Objective:To observe the influence of electro-acupuncture (EA) at Shuigou (GV26) on vascular smooth muscle contraction related Protein Kinase C,to discuss the regulation effect of PKC on vascular smooth muscle contraction and to reveal the molecular mechanism of vascular smooth muscle contraction underlying the acupuncture at Shuigou (GV26) via using Wistar rat middle cerebral artery occlusion (MCAO) model (Middle Cerebral Artery Occlusion,MCAO),detecting PKC expression in the brain artery vascular smooth muscle at different time.Methods:96 healthy male Wistar rats were randomly divided into four groups:model group (n=30),electro-acupuncture group (n=30),sham-operation group (n=30).Each group was further divided except control group into 0.5h,1h,3h,6h and 12h with 6 in each subgroup.Model group were set up by occlusion of the middle cerebral artery.Electro-acupuncture (15Hz,20mA) was applied to ‘Shuigou' (GV 26) for 20 minutes.The middle cerebral arteries on the infarct side of the brain were fixed in formalin,embedded with paraffin,followed by sectioning and staining with immunohistochemistry.Results:Compared with control group,PKC expression levels of model group and acupuncture group of each time-points were both increased (P<0.05).None of difference was observed between Sham-operation group and control group.Remarkable difference existed between model group and the electro-acupuncture at each time-point other than 6h and 12h (P<0.05).PKC expression level of model group was up-regulated with the increasing time-points (P<0.05).There was no difference in electro-acupuncture group between 6h and 12h other than the rest of the time-points (P<0.05).Conclusion:Upregulation of PKC expression during cerebral ischemia underlying mechanisms of MCAO and ischemia injury; PKC expression in rat model of MCAO was significantly down-regulated by EA treatment.%目的:通过检测Wistar大鼠大脑中动脉梗塞(MCAO)后,与血管平滑肌收缩相关的蛋白激酶C

  6. CITICOLIN IN THE TREATMENT OF STROKE AND VASCULAR COGNITIVE DISORDERS

    Directory of Open Access Journals (Sweden)

    Vladimir Anatol'evich Parfenov

    2009-01-01

    Full Text Available Citicolin (ceraxon is used as a neuroprotector in the treatment of acute stroke and vascular cognitive disorders. Experimental animal studies have demonstrated that citicolin reduces the extent of cerebral infarct and increases the degree of functional recovery. A few clinical trials have provided evidence for the efficacy of intravenous or oral citicolin used within the first 24 hours of ischemic stroke or cerebral hemorrhage in recovery of neurological functions. Citicolin is effective in memory and behavioral disorders in elderly patients with chronic cerebrovascular diseases. The use of citicolin has been found to be safe in stroke and vascular cognitive disorders

  7. Motociclistas de entrega: algumas características dos acidentes de trânsito na região sul do Brasil Motorcycle couriers: characteristics of traffic accidents in southern Brazil

    OpenAIRE

    Dorotéia Fátima Pelissari de Paula Soares; Thais Aidar de Freitas Mathias; Daniela Wosiack da Silva; Selma Maffei de Andrade

    2011-01-01

    OBJETIVO: conhecer características dos acidentes de trânsito ocorridos com motoboys nos municípios de Londrina e Maringá, Estado do Paraná. MÉTODOS: Foram considerados 327 motoboys que relataram, em 2005/2006, acidentes de motocicleta nos 12 meses anteriores à pesquisa (147 de Londrina e 180 de Maringá). RESULTADOS: Dos entrevistados, 39,6% relataram mais de um acidente de trânsito. Os acidentes foram percebidos como graves por 21,4% dos motoboys e 56,3% relataram conhecer motoboy afastado do...

  8. A enfermagem frente a acidentes de trabalho com material potencialmente contaminado na era do HIV The nursing team and occupational accidents with potentially contaminated material in the era of HIV

    OpenAIRE

    Elucir Gir; Fabiana Prado Potiens Costa; Adriana Maria da Silva

    1998-01-01

    Realizou-se esta investigação, com os objetivos de identificar a ocorrência de acidentes de trabalho com material pérfuro-cortante potencialmente contaminado, entre enfermeiros e auxiliares de enfermagem de um Hospital de ensino geral do interior do Estado de São Paulo; relacionar a ocorrência destes acidentes com a categoria profissional e anos de trabalho na instituição; identificar o tipo de material pérfuro-cortante causador do acidente e identificar as condutas tomadas após o acidente, p...

  9. Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy

    OpenAIRE

    Bertsch, Thomas; Mielke, Orell; Höly, Sabine; Zimmer, Wilma; Casarin, Wendy; Aufenanger, Johannes; Walter, Silke; Muehlhauser, Frank; Kuehl, Sandra; Ragoschke, Andreas; Fassbender, Klaus

    2001-01-01

    Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading to dementia. These results were compared to the homocysteine and vitamin plasma concentrations from patients with cerebral large vessel disease and healthy control subjects. Plasma concentrations of homocysteine, vascular risk factors and vita...

  10. Acidentes de transporte terrestre em município da Região Sul do Brasil

    Directory of Open Access Journals (Sweden)

    Selma Maffei de Andrade

    2001-06-01

    Full Text Available Foram estudadas as características dos acidentes de transporte terrestre, com 3.643 vítimas, ocorridos no primeiro semestre de 1996, em Londrina, PR. O tipo de acidente mais freqüente foi a colisão com carro/caminhonete. A frota de motocicletas foi a que gerou a maior taxa de vítimas (cerca de sete vezes a apresentada por carros/caminhonetes. Maior risco de óbito foi evidenciado entre motociclistas que colidiram com objeto fixo (letalidade de 29,4%, seguido por pedestres atropelados por caminhão ou ônibus (22,2%, muito superiores ao coeficiente médio (1,8%. O conhecimento desses aspectos é elemento norteador de políticas públicas para a redução da morbimortalidade por essa causa.

  11. Acidentes de transporte terrestre em município da Região Sul do Brasil

    Directory of Open Access Journals (Sweden)

    Andrade Selma Maffei de

    2001-01-01

    Full Text Available Foram estudadas as características dos acidentes de transporte terrestre, com 3.643 vítimas, ocorridos no primeiro semestre de 1996, em Londrina, PR. O tipo de acidente mais freqüente foi a colisão com carro/caminhonete. A frota de motocicletas foi a que gerou a maior taxa de vítimas (cerca de sete vezes a apresentada por carros/caminhonetes. Maior risco de óbito foi evidenciado entre motociclistas que colidiram com objeto fixo (letalidade de 29,4%, seguido por pedestres atropelados por caminhão ou ônibus (22,2%, muito superiores ao coeficiente médio (1,8%. O conhecimento desses aspectos é elemento norteador de políticas públicas para a redução da morbimortalidade por essa causa.

  12. Cerebral cysticercosis

    International Nuclear Information System (INIS)

    Two cases of histologically proven cerebral cysticercosis are presented. In both cases subcutaneous tissue nodules, a rare feature, were present. Several disease patterns are apparent - meningeal, parenchymatous and ventricular, spinal cord lesions and mixed patterns. Epilepsy is by far the major presenting symptom of cysticercosis, which in turn plays a significant role in the causation of adult-onset epilepsy in Blacks. Despite its drawbacks, the haemag-glutination inhibition test remains the most satisfactory serological method at present available for the diagnosis of cysticercosis; it is positive in up to 85% of cases of proven cysticercosis. With the advent of computed tomography many cases of unsuspected cysticercosis (symptomatic or asymptomatic) are being discovered

  13. Epidemiologia dos acidentes ofídicos nos últimos 100 anos no Brasil: uma revisão

    Directory of Open Access Journals (Sweden)

    Bochner Rosany

    2003-01-01

    Full Text Available Neste trabalho foram analisados 22 artigos, 4 livros, 3 relatórios e 1 manual publicados no período de 1901 a 2000, que tratam de acidentes ofídicos ocorridos no Brasil. Concluiu-se que as análises epidemiológicas realizadas nos últimos 100 anos são baseadas nas mesmas variáveis já apontadas por Vital Brazil em seu Boletim para Observação de Accidente Ophidico, ou seja, variáveis referentes ao indivíduo, ao evento e ao atendimento. O perfil epidemiológico desses acidentes também se manteve inalterado ao longo dos anos, isto é, são mais comuns em pessoas do sexo masculino, em trabalhadores rurais, na faixa etária de 15 a 49 anos, atingem principalmente os membros inferiores e a maioria desses acidentes é atribuída às serpentes do gênero Bothrops.

  14. Neuropsychological Effects of Cerebral Amyloid Angiopathy.

    Science.gov (United States)

    Schrag, Matthew; Kirshner, Howard

    2016-08-01

    Cerebral amyloid angiopathy is a condition of the cerebral arterioles and to a lesser extent capillaries and veins, wherein beta-amyloid is deposited. In arterioles, this preferentially targets vascular smooth muscle cells and in the later stages undermines the stability of the vessel. This condition is frequently comorbid with Alzheimer's disease and its role in cognitive impairment and dementia is a topic of considerable recent research. This article reviews recent literature which confirms that CAA independently contributes to cognitive impairment by potentiating the neurodegeneration of Alzheimer's disease, by predisposing to microhemorrhagic and microischemic injury to the brain parenchyma, and by interfering with the autoregulation of CNS blood flow. In this review, we discuss the clinical presentation of cerebral amyloid angiopathy, with a focus on the neuropsychological manifestations of this vasculopathy. PMID:27357378

  15. An experimental study of pioglitazone in treating vascular dementia

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Objective To compare the therapeutic effects of different doses of pioglitazone,a kind of peroxisome proliferator-activated receptor γ(PPARγ)agonist,on vascular dementia and explore how pioglitazone affects cerebral ischemia.Methods Modified Pulsinelli's vessel ligation was used to establish a vascular dementia model in rats.Recognition,learning and memory were evaluated by Morris's water maze test.Immunoenzyme staining was used to determine the number of nerve cells.Immunofluorescence double-staining was u...

  16. Wearable wireless cerebral oximeter (Conference Presentation)

    Science.gov (United States)

    Zhang, Xin; Jiang, Tianzi

    2016-03-01

    Cerebral oximeters measure continuous cerebral oxygen saturation using near-infrared spectroscopy (NIRS) technology noninvasively. It has been involved into operating room setting to monitor oxygenation within patient's brain when surgeons are concerned that a patient's levels might drop. Recently, cerebral oxygen saturation has also been related with chronic cerebral vascular insufficiency (CCVI). Patients with CCVI would be benefited if there would be a wearable system to measure their cerebral oxygen saturation in need. However, there has yet to be a wearable wireless cerebral oximeter to measure the saturation in 24 hours. So we proposed to develop the wearable wireless cerebral oximeter. The mechanism of the system follows the NIRS technology. Emitted light at wavelengths of 740nm and 860nm are sent from the light source penetrating the skull and cerebrum, and the light detector(s) receives the light not absorbed during the light pathway through the skull and cerebrum. The amount of oxygen absorbed within the brain is the difference between the amount of light sent out and received by the probe, which can be used to calculate the percentage of oxygen saturation. In the system, it has one source and four detectors. The source, located in the middle of forehead, can emit two near infrared light, 740nm and 860nm. Two detectors are arranged in one side in 2 centimeters and 3 centimeters from the source. Their measurements are used to calculate the saturation in the cerebral cortex. The system has included the rechargeable lithium battery and Bluetooth smart wireless micro-computer unit.

  17. Cerebrovascular angiotensin AT1 receptor regulation in cerebral ischemia

    DEFF Research Database (Denmark)

    Edvinsson, Lars

    2008-01-01

    The mechanism behind the positive response to the inhibition of the angiotensin II receptor AT(1) in conjunction with stroke is elusive. Here we demonstrate that cerebrovascular AT(1) receptors show increased expression (upregulation) after cerebral ischemia via enhanced translation. This enhanced...... expression of AT(1) receptors occurs in the ischemic cerebral arteries and microvessels, and their inhibition results in a reduction in infarct volume. These findings add to the understanding of the vascular component in stroke, and the identified inhibition provides a new way to reduce the extent...... of cerebral ischemic damage....

  18. Society for Vascular Medicine

    Science.gov (United States)

    ... 2017 Learn more Patient Information Pages from Vascular Medicine August 2016 The Vascular Laboratory More info for ... Learn more. Trending Now: Hot Topics in Vascular Medicine Video Series Fibromuscular Dysplasia (FMD) with Drs. Jeffrey ...

  19. Cerebral hemodynamic dysfunction in parkinsonian patients

    Directory of Open Access Journals (Sweden)

    Mirjana Vladetić

    2009-02-01

    Full Text Available Aim The purpose of this investigation was to determine the cerebral hemodynamics in patients withparkinsonism and the influence of hemodynamic dysfunction in developing the lacunar infarcts.Methods Fifty patients with the signs of parkinsonism were included in this study. The patients weredevided into two subgroups depending on whether they had vascular parkinsonism (VP (N-22 or idiopathicParkinson disease (N-28. The control group consisted of 30 patients who had ischemic stroke.The conventional transcranial dopler sonography was performed to evaluate the cerebral blood flow.To evaluate the cognitive impairment we performed the mini mental state examination to patients withparkinsonism.Results Patients with vascular parkinsonism have greater cognitive disturbances than patients withParkinson disease. In most of the parkinsonian patients the cerebral blood flow was decreased and themicroangiopathy was present.Conclusion In most patients with parkinsonism, the cerebral blood flow was decreased as a consequenceof microangiopathy. In our opinion, this led to lacunar infarction in VP patients, but can also bea risk factor for developing the same changes in patients with idiopathic Parkinson disease.

  20. Does the risk of cerebral palsy increase or decrease with increasing gestational age?

    OpenAIRE

    Murphy-Kaulbeck Lynn; Lutfi Samawal; Allen Alexander C; Joseph K S; Vincer Michael J; Wood Ellen

    2003-01-01

    Abstract Background It is generally accepted that the risk of cerebral palsy decreases with increasing gestational age of live born infants. However, recent studies have shown that cerebral palsy often has prenatal antecedents including congenital malformations, vascular insults and maternal infection. Cerebral palsy is therefore better viewed as occurring among fetuses, rather than among infants. We explored the epidemiologic implications of this change in perspective. Methods We used recent...

  1. A schizophrenic patient with cerebral infarctions after hemorrhagic shock

    Directory of Open Access Journals (Sweden)

    Youichi Yanagawa

    2013-01-01

    Full Text Available We herein report the fourth case of cerebral infarction, concomitant with hemorrhagic shock, in English literature. A 33-year-old male, who had been diagnosed with schizophrenia and given a prescription for Olanzapine, was discovered with multiple self-inflicted bleeding cuts on his wrist. On arrival, he was in hemorrhagic shock without verbal responsiveness, but his vital signs were normalized following infusion of Lactate Ringer′s solution. The neuroradiological studies revealed multiple cerebral ischemic lesions without any vascular abnormality. He was diagnosed with speech apraxia, motor aphasia, and dysgraphia, due to multiple cerebral infarctions. As there was no obvious causative factor with regard to the occurrence of cerebral infarction in the patient, the hypoperfusion due to hemorrhagic shock, and the thromboembolic tendency due to Olanzapine, might have acted together to lead to the patient′s cerebral ischemia.

  2. Closed-Loop Dynamic Modeling of Cerebral Hemodynamics

    Science.gov (United States)

    Marmarelis, V. Z.; Shin, D. C.; Orme, M. E.; Zhang, R.

    2013-01-01

    The dynamics of cerebral hemodynamics have been studied extensively because of their fundamental physiological and clinical importance. In particular, the dynamic processes of cerebral flow autoregulation and CO2 vasomotor reactivity have attracted broad attention because of their involvement in a host of pathologies and clinical conditions (e.g. hypertension, syncope, stroke, traumatic brain injury, vascular dementia, Alzheimer’s disease, mild cognitive impairment etc.). This raises the prospect of useful diagnostic methods being developed on the basis of quantitative models of cerebral hemodynamics, if cerebral vascular dysfunction can be quantified reliably from data collected within practical clinical constraints. This paper presents a modeling method that utilizes beat-to-beat measurements of mean arterial blood pressure, cerebral blood flow velocity and end-tidal CO2 (collected non-invasively under resting conditions) to quantify the dynamics of cerebral flow autoregulation (CFA) and cerebral vasomotor reactivity (CVMR). The unique and novel aspect of this dynamic model is that it is nonlinear and operates in a closed-loop configuration. PMID:23292615

  3. Lesões do aparelho locomotor nos acidentes com motocicleta Musculoskeletal injuries in motorcycle accidents

    Directory of Open Access Journals (Sweden)

    Pedro Debieux

    2010-01-01

    Full Text Available Estudo realizado no município de São Paulo entre janeiro de 2001 e julho de 2002 e tem como objetivo analisar o perfil do indivíduo envolvido em acidentes motociclísticos avaliando: o perfil do condutor, as circunstâncias dos acidentes, as lesões e o uso de equipamentos de segurança. Foram encontrados 387 pacientes sendo 354(91,0% do sexo masculino, entre 16 e 44 anos e considerados os indivíduos que necessitaram somente do tratamento traumato-ortopédico. O mecanismo de trauma mais comum envolveu a colisão entre a moto com outro veículo (67,0%, numa velocidade entre 20-60km/h (73,0%, em pessoas com menor experiência (67,0% na idade entre 21-24 anos (45,0%, nos quais 532 (53,9% lesões ocorreram nos membros inferiores. Quanto ao tipo de lesão tivemos 393(39,8% ferimentos, 314(31,8% contusões e 212(21,5% fraturas [ossos do pé 34(16%, fêmur 32(15,1%, tornozelo 27(12,7%, tíbia 25(11,8%]. A reincidência foi observada em 231(60,0% acidentes e somente 6,0% dos pacientes não usavam equipamentos de proteção.O aumento da velocidade relacionou-se à um índice maior de fraturas quando foi aplicado o teste de Mann-Whitney (p=0,001. Pesquisas de engenharia mecânica e de engenharia de tráfego, associadas à rigorosa fiscalização e conscientização da população, devem ser consideradas o método mais efetivo , que é o da prevenção.Study conducted in the city of São Paulo from January 2001 to July 2002 with the goal of analyzing the profiles of individuals involved in motorcycle accidents, evaluating the rider's profile, the circumstances of the accidents, injuries, and the use of protective gear. 387 patients needing only traumatic orthopedic treatment were found, between 16 and 44 years of age, of which 354 were males (91.0%. The most common mechanism of trauma involved a collision between the motorcycle and another vehicle (67.0% at a speed between 12.5-37.5 mph (73.0% involving less experienced riders (67.0% between 21 and 24

  4. Vascular endothelial growth factor:an attractive target in the treatment of hypoxic/ischemic brain injury

    Institute of Scientific and Technical Information of China (English)

    Hui Guo; Hui Zhou; Jie Lu; Yi Qu; Dan Yu; Yu Tong

    2016-01-01

    Cerebral hypoxia or ischemia results in cell death and cerebral edema, as well as other cellular reactions such as angiogenesis and the reestablishment of functional microvasculature to promote recovery from brain injury. Vascular endothelial growth factor is expressed in the central nervous system after hypoxic/ischemic brain injury, and is involved in the process of brain repairvia the regulation of angiogenesis, neurogenesis, neurite outgrowth, and cerebral edema, which all require vascular endothelial growth factor signaling. In this review, we focus on the role of the vascular endothelial growth factor signaling pathway in the response to hypoxic/ischemic brain injury, and discuss potential therapeutic interventions.

  5. Sonolência e acidentes automobilísticos Sleepiness and motor vehicle accidents

    Directory of Open Access Journals (Sweden)

    SIMONE FAGONDES CANANI

    2001-03-01

    Full Text Available Objetivo: Este artigo tem por finalidade apresentar uma sucinta revisão sobre as repercussões da sonolência excessiva no desempenho dos motoristas no trânsito, enfatizando a necessidade da maior valorização do tema abordado. Métodos: Revisão bibliográfica da literatura nacional e internacional, abrangendo artigos originais e publicações oficiais da American Thoracic Society e da American Sleep Apnea Association. Resultados: As evidências de que a sonolência é um fator que pode contribuir de forma decisiva para a ocorrência de acidentes automobilísticos são crescentes. As dificuldades com relação à caracterização da sonolência precedendo o acidente são discutidas no texto. Muitas são as causas de sonolência excessiva; felizmente, sua maioria é passível de identificação e manejo adequado. Conclusões: É importante que haja maior entendimento do problema em nosso meio, para que possam ocorrer modificações na abordagem do paciente com sonolência excessiva e também discussões acerca das leis de trânsito vigentes e das obrigações legais do médico com relação a este problema.Objective: The purpose of this article is to present a brief review of the effects of excessive sleepiness on driving performance, and to emphasize the importance of the subject. Methods: Bibliographic review of national and international literature, including original articles and official publications from the American Thoracic Society and the American Sleep Apnea Association. Results: There is growing evidence that excessive sleepiness may be an important factor related to the occurrence of motor vehicle accidents. Difficulties regarding the identification of sleepiness as a preceding factor related to motor vehicle crashes are discussed on the text. There are many causes for excessive sleepiness. Fortunately most of them are easy to recognize and have specific treatment. Conclusions: A better understanding of the problem is fundamental

  6. Characteristics and clinical application of different types of cerebral vascular scaffolds%不同类型脑血管支架材料的特点及临床应用

    Institute of Scientific and Technical Information of China (English)

    梅敏杰

    2014-01-01

    BACKGROUND:With the development of the basic research and clinical application, as wel as stent materials, endovascular stent therapy has been widely used in cerebrovascular disease treatment. OBJECTIVE:To review the characteristics and clinical application of several kinds of stent materials. METHODS: A computer-based search of CNKI, Wanfang, and PubMed databases was performed for relevant articles published before Match 2014 using the keywords of “cerebrovascular disease, stents, biocompatibility” in Chinese and English. RESULTS AND CONCLUSION:According to release methods, cerebrovascular stents can be divided into baloon expanding stents and self-expanding stents. The original materials are mainly bare metal materials, made of memory aloy, medical stainless steel, tantalum, cobalt, nickel and titanium aloy. Because the metalic stent after implantation wil release metal ions that are easy to cause thrombosis and the restenosis rate is high, the coating stents and covered stents appear. Perioperative complications of stent implantation mainly include excessive perfusion syndrome, acute thrombosis, and vascular rupture and distal vascular embolization, vasospasm and puncture-related complications; the long-term complications are mainly restenosis after stent implantation. With the continuous improvement of stent materials and production techniques, vascular stent implantation wil be more safe and effective.%背景:随着基础研究、临床应用,以及血管支架材料的不断发展,血管内支架置入治疗已被广泛应用于脑血管疾病治疗中。目的:综述这几种支架材料的特点及临床应用情况。方法:应用计算机检索CNKI数据库、万方数据库、PubMed数据库从建库到2014年3月的相关文献,中文检索关键词为“脑血管病,支架,生物相容性”,英文检索关键词为“cerebrovascular disease,stents, biocompatibility”。结果与结论:按释放方式可将脑血管支架

  7. Quantitative detection of cerebral arteriosclerosis by means of the Doppler ultrasonic technique.

    Science.gov (United States)

    Miyazaki, M

    1986-01-01

    A correlation between the continuity of the cerebral blood flow pattern and the cerebral vascular resistance (namely, cerebral arteriosclerosis) was investigated by the Doppler ultrasonic technique. The following facts were observed. Examination of the brachial blood flow pattern in circulatory stress, i.e., hand-grasping, brachial-binding, cold- and warm-stimulating tests revealed that the more the peripheral vascular resistance was increased, the more was the discontinuity of brachial blood flow pattern increased. Investigation of the continuity of the cerebral blood flow pattern (internal carotid artery) in 18 young healthy persons and 46 elderly patients with cerebral vascular diseases revealed a continuous pattern in all of the young persons, while the discontinuous pattern was frequently observed in the elderly patients. These findings suggest that the cerebral vascular resistance is more increased in the elderly patients than in the young persons. The cerebral blood flow pattern was classified into the following three types according to the continuity of the cerebral blood flow pattern: continuous, intermediate and discontinuous type, and the relation to the Continuous Index (CI), which was devised as an objective parameter of the continuity, was examined. The following CI figures were obtained: 110-200% in the young persons; in the elderly patients: continuous type, 120-185%; intermediate type, 85-135%; discontinuous type, 50-85%. From the above findings it is postulated that the Doppler ultrasonic technique is useful for the quantitative detection of cerebral arteriosclerosis, i.e., anticipation of cerebral vascular accidents, and for the discrimination between arteriosclerotic dementia and Alzheimer's disease. PMID:3525327

  8. Serpentes da área urbana de Cuiabá, Mato Grosso: aspectos ecológicos e acidentes ofídicos associados

    Directory of Open Access Journals (Sweden)

    Marcos André de Carvalho

    1998-10-01

    Full Text Available São apresentadas informações sobre as serpentes da área urbana do Município de Cuiabá, Mato Grosso, potencialmente causadoras de acidentes ofídicos. As informações estão baseadas em exemplares doados por populares ao Núcleo de Ofiologia Regional de Mato Grosso (Normat entre 1986 e 1993 e em registros efetuados pelo Centro de Informações Anti-Veneno (Ciave entre 1988 e 1993, que não fazem referência ao animal causador. Foram catalogadas 37 espécies de serpentes, em 25 gêneros e 3 famílias, com hábitos predominantemente diurnos, terrestres e com dietas baseadas em anfíbios e/ou lagartos. Dentre os 307 acidentes ofídicos registrados, 56% foram causados por serpentes sem interesse médico e 44% constituíram acidentes de importância médica. Cerca de 99% dos acidentes de importância médica foram atribuídos ao gênero Bothrops (Bothrops moojeni e Bothrops neuwiedi seriam as principais causadoras. Dentre as espécies sem interesse médico, Philodryas olfersii e Waglerophis merremii provavelmente foram as principais responsáveis pela maior parte dos acidentes.

  9. Serpentes da área urbana de Cuiabá, Mato Grosso: aspectos ecológicos e acidentes ofídicos associados

    Directory of Open Access Journals (Sweden)

    Carvalho Marcos André de

    1998-01-01

    Full Text Available São apresentadas informações sobre as serpentes da área urbana do Município de Cuiabá, Mato Grosso, potencialmente causadoras de acidentes ofídicos. As informações estão baseadas em exemplares doados por populares ao Núcleo de Ofiologia Regional de Mato Grosso (Normat entre 1986 e 1993 e em registros efetuados pelo Centro de Informações Anti-Veneno (Ciave entre 1988 e 1993, que não fazem referência ao animal causador. Foram catalogadas 37 espécies de serpentes, em 25 gêneros e 3 famílias, com hábitos predominantemente diurnos, terrestres e com dietas baseadas em anfíbios e/ou lagartos. Dentre os 307 acidentes ofídicos registrados, 56% foram causados por serpentes sem interesse médico e 44% constituíram acidentes de importância médica. Cerca de 99% dos acidentes de importância médica foram atribuídos ao gênero Bothrops (Bothrops moojeni e Bothrops neuwiedi seriam as principais causadoras. Dentre as espécies sem interesse médico, Philodryas olfersii e Waglerophis merremii provavelmente foram as principais responsáveis pela maior parte dos acidentes.

  10. CONTEMPORARY APPROACH TO THE CORRECTION OF COGNITIVE DISORDERS IN PATIENTS WITH VASCULAR COMORBIDITY

    Directory of Open Access Journals (Sweden)

    S. A. Rumianceva

    2013-01-01

    Full Text Available Various aspects of the therapy of patients with cognitive impairments and vascular comorbidity, including cerebral stroke and chronic brain ischemia associated with cardiac and endocrine diseases are discussed. Influence of vascular cognitive and psycho-emotional disorders on the social and everyday activity is demonstrated. Clinical studies of efficacy and safety of vinpocetine treatment in these patients are presented.

  11. Vascular retinopathy in relation to cognitive functioning in an older population--the Hoorn Study

    NARCIS (Netherlands)

    Heringa, S.M.; Walraven, I.; Moll, A.C.; van den Berg, E.; Nijpels, G.; Stehouwer, C.D.; Reijmer, Y.D.; Kappelle, L.J.; Dekker, J.; Biessels, G.J.

    2014-01-01

    To the Editor: Cognitive impairment and dementia are important health problems that may be caused by vascular damage in the brain.[1] The cerebral vasculature is anatomically, embryologically, and physiologically related to that of the retina, and both are sensitive to exposure to vascular risk fact

  12. CONTEMPORARY APPROACH TO THE CORRECTION OF COGNITIVE DISORDERS IN PATIENTS WITH VASCULAR COMORBIDITY

    Directory of Open Access Journals (Sweden)

    S. A. Rumianceva

    2015-09-01

    Full Text Available Various aspects of the therapy of patients with cognitive impairments and vascular comorbidity, including cerebral stroke and chronic brain ischemia associated with cardiac and endocrine diseases are discussed. Influence of vascular cognitive and psycho-emotional disorders on the social and everyday activity is demonstrated. Clinical studies of efficacy and safety of vinpocetine treatment in these patients are presented.

  13. United Cerebral Palsy

    Science.gov (United States)

    ... be sure to follow us on Twitter . United Cerebral Palsy UCP educates, advocates and provides support services to ... Partners Merz Logo Sprint Relay Copyright © 2015 United Cerebral Palsy 1825 K Street NW Suite 600 Washington, DC ...

  14. Time-varying modeling of cerebral hemodynamics.

    Science.gov (United States)

    Marmarelis, Vasilis Z; Shin, Dae C; Orme, Melissa; Rong Zhang

    2014-03-01

    The scientific and clinical importance of cerebral hemodynamics has generated considerable interest in their quantitative understanding via computational modeling. In particular, two aspects of cerebral hemodynamics, cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity (CVR), have attracted much attention because they are implicated in many important clinical conditions and pathologies (orthostatic intolerance, syncope, hypertension, stroke, vascular dementia, mild cognitive impairment, Alzheimer's disease, and other neurodegenerative diseases with cerebrovascular components). Both CFA and CVR are dynamic physiological processes by which cerebral blood flow is regulated in response to fluctuations in cerebral perfusion pressure and blood CO2 tension. Several modeling studies to date have analyzed beat-to-beat hemodynamic data in order to advance our quantitative understanding of CFA-CVR dynamics. A confounding factor in these studies is the fact that the dynamics of the CFA-CVR processes appear to vary with time (i.e., changes in cerebrovascular characteristics) due to neural, endocrine, and metabolic effects. This paper seeks to address this issue by tracking the changes in linear time-invariant models obtained from short successive segments of data from ten healthy human subjects. The results suggest that systemic variations exist but have stationary statistics and, therefore, the use of time-invariant modeling yields "time-averaged models" of physiological and clinical utility.

  15. Cerebral metabolism in streptozotocin-diabetic rats: an in vivo magnetic resonance spectroscopy study

    NARCIS (Netherlands)

    Gispen, W.H.; Biessels, G.J.; Braun, K.P.; Graaf, R.A. de; Eijsden, P. van; Nicolay, K.

    2001-01-01

    Aims/hypothesis. It is increasingly evident that the brain is another site of diabetic end-organ damage. The pathogenesis has not been fully explained, but seems to involve an interplay between aberrant glucose metabolism and vascular changes. Vascular changes, such as deficits in cerebral blood flo

  16. Advances in TCM Treatment of Senile Vascular Dementia

    Institute of Scientific and Technical Information of China (English)

    薛长连; 薛佩连; 王勤; 郭秀丽

    2002-01-01

    @@ Senile vascular dementia refers to organic loss of intellectual function due to cerebral damages caused by insufficient blood supply. The following is a summaryon achievements in its etiology, pathogenic mechanism, type identification and treatment in TCM, and the compound formulas, special formulas and drugs, and thepatent drugs used successfully for its treatment.

  17. Cerebral palsy and epilepsy

    OpenAIRE

    Knežević-Pogančev Marija

    2010-01-01

    Introduction. Cerebral palsy is the most common cause of physical disability in early childhood. Epilepsy is known to have a high association with cerebral palsy. All types of epileptic seizures can be seen in patients with cerebral palsy. Complex partial and secondary generalized ones are the most frequent seizure types. In persons with cerebral palsy and mental retardation, the diagnosis of epilepsy presents unique difficulties. Generally they are not able to describe the epileptic ev...

  18. 104例颅内动脉瘤和脑血管畸形患者氧治疗方案探讨%Observation on the therapeutic effects of different oxygen therapy protocols in the treatment of 104 patients with intracranial aneurysm and cerebral vascular malformations

    Institute of Scientific and Technical Information of China (English)

    卢晓欣; 彭慧平; 汤永建; 房卫红

    2012-01-01

    Objective To observe the therapeutic effects of different oxygen therapy protocols in the treatment of patients with intracranial aneurysm and cerebral vascular malformations. Methods Forty-one cases of intracranial aneurysm and 63 cases of various cerebral vascular malformations (with a total of 104 cases) were treated with different oxygen therapy protocols.High-flow normal pressure oxygen (NPO) therapy outside the chamber was given to 25 patients either with intracranial aneurysm or cerebral vascular malformation,who failed to receive surgical operation or endovascular treatment,or their family members refused to accept hyperbaric oxygen (HBO) therapy.Seventy-nine cases were treated with progressive HBO therapy protocol,i.e.treatment started with high-flow oxygen therapy outside the chamber,HBO therapy started from a lower pressure to a higher pressure,and a therapy protocol with relatively slower compression and decompression rates was adopted (with compression and decompression rates of 3- 4 kPa/min,the therapeutic pressure of 0.175 MPa and oxygen breathing for 60 min at stable pressure).At the same time,vital signs and ECG were analyzed,therapeutic effects and safety of the protocols were evaluated.Results Total effective rate for HBO therapy and high-flow NPO therapy outside the chamber was 97.5% and 40.0%.The therapeutic effectiveness of HBO therapy was superior to that of the high-flow NPO therapy outside the chamber,with statistical significance ( P < 0.05 ). Vital signs and ECG monitoring indicated that heart rate decreased [(83.63±15.80)/min]following HBO therapy,and statistical difference could be noted,when it was compared with those of the patients treated with high-flow NPO therapy outside the chamber.Arterial oxygen saturation all elevated for the two therapy protocols,but without statistical significance.As compared with those before compression,systolic and diastolic pressures all increased,when HBO therapy was implemented (P <0

  19. Pumps, Aqueducts, and Drought Management: vascular physiology in vascular cognitive impairment

    OpenAIRE

    Marshall, Randolph S.; Lazar, Ronald M

    2010-01-01

    Vascular cognitive impairment has been traditionally defined by structural pathology – an accumulation of infarcts -- leading to progressive cognitive decline. Recent evidence, however, suggests that cognitive impairment may be independently mediated by hemodynamic dysfunction including global and hemispheral hypoperfusion and altered cerebral blood flow regulation. In this review we examine evidence for the contribution of hemodynamic impairment to cognitive dysfunction in the setting of lar...

  20. Generación de agrupamientos semánticos en una tarea de fluidez verbal en pacientes víctimas de un Accidente Cerebro Vascular y controles sin patología cerebral.

    Directory of Open Access Journals (Sweden)

    Leticia Vivas

    2010-12-01

    Full Text Available Este artículo se propone comparar el desempeño de tres grupos de personas en una tarea de fluidez verbal semántica: pacientes que sufrieron un Accidente Cerebro Vascular (ACV, adultos mayores sanos y adultos jóvenes sanos. La tarea consiste en solicitarle a lo participantes que emitan la mayor cantidad de ejemplares que conozcan de una categoría semántica en un lapso de tiempo de un minuto. En este caso se escogió la categoría animales. En primer lugar, el análisis de varianza permitió detectar diferencias de medias significativas (p<0.05 en la cantidad de palabras emitidas por grupo, siendo los pacientes los que produjeron menor cantidad de ejemplares. Luego, se realizó un escalamiento multidimensional por grupo para analizar los agrupamientos de los ejemplares de acuerdo al orden en que fueron emitidos. Se observó que los pacientes son los que generaron menor cantidad de agrupamientos y los adultos jóvenes mayor cantidad de agrupamientos. De este modo, cabe suponer que existe una asociación entre la escasa conformación de agrupamientos y la dificultad en la recuperación de ejemplares de la memoria semántica. Así, tanto en el grupo de pacientes como en las personas adultas mayores (en menor grado habría un funcionamiento deficiente los mecanismos de recuperación de la información semántica que disminuiría la capacidad de generar ejemplares de una categoría semántica.

  1. Animal Models of Vascular Cognitive Impairment and Dementia (VCID).

    Science.gov (United States)

    Gooch, Jennifer; Wilcock, Donna M

    2016-03-01

    Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly. Both, vascular and Alzheimer's disease, pathologies work synergistically to create neurodegeneration and cognitive impairments. The main causes of VCID include hemorrhage/microbleed (i.e., hyperhomocysteinemia), cerebral small vessel disease, multi-infarct dementia, severe hypoperfusion (i.e., bilateral common carotid artery stenosis), strategic infarct, angiopathy (i.e., cerebral angiopathy), and hereditary vasculopathy (i.e., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). In this review, we will discuss the experimental animal models that have been developed to study these pathologies. We will discuss the limitations and strengths of these models and the important research findings that have advanced the field through the use of the models. PMID:26988696

  2. Sublingual Microvascular Changes in Patients With Cerebral Small Vessel Disease

    NARCIS (Netherlands)

    M. Khalilzada; K. Dogan; C. Ince; J. Stam

    2011-01-01

    Background and Purpose-It is unknown whether changes in cerebral small vessel disease (SVD) are limited to the brain or part of a generalized vascular disorder. Methods-We examined the sublingual microcirculation of 10 healthy controls, 10 patients with large vessel disease, and 8 with SVD, with sid

  3. Vitamin E but not 17B-estradiol protect against vascular toxicity induced by B-amyloid wild type and the Dutch amyploid variant

    OpenAIRE

    Mu??oz L??pez, Francisco Jos??, 1964-; Opazo, Carlos; Gil G??mez, Gabriel; Tapia, Gladys; Fern??ndez, Virginia; Valverde, M A; Nibaldo C Inestrosa

    2002-01-01

    Amyloid ??-peptide (A??) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called hereditary cerebral hemorrhage with amyloidosis of the Dutch type is caused by a point mutation in A?? yielding A??Glu22???Gln. The present study addresses the effect of amyloid fibrils from both wild-type and mutated A?? on vascular cells, as well as the putative protect...

  4. 存在血管危险因素的老年人脑白质损害与认知功能障碍的关系%Relationship between cerebral white matter lesions and cognitive function disorder in old people with vascular risk factors

    Institute of Scientific and Technical Information of China (English)

    沈树红; 王少石; 张会军; 宋彦彦

    2011-01-01

    Objective To examine the relationship between cerebral white matter lesions(WML)of different severity and the cognitive impairment in old people with vascular risk factors. Methods According to WML score,195 participants with WML were divided into mild WML group,medium WML group and severe WML group. The control group (n = 70) consisted of healthy old people without WML. All participants underwent neuropsychological tests including Mini Mental State Examination, Montreal Cognitive Assessment, Auditory Verbal Learning Test, Logical Memory Test, Rey-Osterrieth Complex Figure Test, Stroop Colour-Word Test, Trail Making Test,Similarity Test,Animals Category Fluency Test,Digital Span Test,Belling Test and Clock Drawing Test. Results The vascular risk factors increased as WML extent aggravated (P < 0. 05). Mild WML group had apparent decline in the memory score,attention score and part of the performance function score compared with the control group,the difference was statistically significant (P <0. 05,F<0. 01). The severe WML group had dramatic decline in all cognitive function scores compared with other groups, the differences were statistically significant. All of the cognitive function scores were inversely correlated with severity of WML (P < 0. 01). Conclusion Vascular risk factors could aggravate WML. Mild WML could impair cognitive function, while severe WML showed extensive cognitive impairment. Degree of cognitive impairment was positively correlated to severity of WML in old people with vascular risk factors.%目的 探讨存在血管危险因素老年人不同程度脑白质损害(WML)与认知障碍的关系.方法 选择WML患者195例,根据WML程度分为轻度组(54例),中度组(63例),重度组(78例),另选健康体检者70例作为对照组.所有受试者行神经心理学测试,包括简易智能状态检查量表、蒙特利尔认知评估量表、听觉词语记忆、逻辑记忆、复杂图形记忆、Stroop色词测验、连线测验B、相

  5. Vascular Dynamics Aid a Coupled Neurovascular Network Learn Sparse Independent Features: A Computational Model

    OpenAIRE

    Philips, Ryan T.; Chhabria, Karishma; Chakravarthy, V Srinivasa

    2016-01-01

    Cerebral vascular dynamics are generally thought to be controlled by neural activity in a unidirectional fashion. However, both computational modeling and experimental evidence point to the feedback effects of vascular dynamics on neural activity. Vascular feedback in the form of glucose and oxygen controls neuronal ATP, either directly or via the agency of astrocytes, which in turn modulates neural firing. Recently, a detailed model of the neuron-astrocyte-vessel system has shown how vasomot...

  6. Prevalence of cerebral aneurysm in patients with acromegaly.

    Science.gov (United States)

    Oshino, Satoru; Nishino, Akio; Suzuki, Tsuyoshi; Arita, Hideyuki; Tateishi, Akihiro; Matsumoto, Katsumi; Shimokawa, Toshio; Kinoshita, Manabu; Yoshimine, Toshiki; Saitoh, Youichi

    2013-06-01

    The prevalence of cerebral aneurysm was retrospectively investigated in 208 patients with acromegaly relative to the rate of cerebral aneurysm in a group of control subjects. Neuroradiological examinations of the cerebral vascular system were conducted in 208 acromegaly patients (101 men; mean age, 48.8 years). The prevalence of cerebral aneurysm in the acromegaly patients was compared to that in a control group consisting of 7,390 subjects who underwent "brain checkup" between 2006 and 2008 (mean age, 51.6 years). In the acromegaly group, cerebral aneurysm was detected in 4.3 % of patients. By sex, the prevalence was 6.9 % in males, a significantly proportion than that in the control group with an odds ratio of 4.40. The prevalence in females did not differ between the two groups. In the acromegaly group, the rate of hypertension was significantly higher in the patients with aneurysm compared to those without aneurysm. Multiple logistic regression identified acromegaly as a significant factor related to the prevalence of cerebral aneurysm in all male subjects; other factors, such as age, hypertension and smoking, were not found to be significant. A significantly higher prevalence of cerebral aneurysm was detected in male patients with acromegaly. This finding indicates that excess growth hormone or insulin-like growth factor 1 affects the cerebral vascular wall, resulting in aneurysm formation. In addition to known systematic complications in the cardiovascular, respiratory, metabolic, and other systems, the risk of cerebral aneurysm should be considered in the management of acromegaly.

  7. Cerebral microangiopathies; Zerebrale Mikroangiopathien

    Energy Technology Data Exchange (ETDEWEB)

    Linn, Jennifer [Klinikum der Universitaet Muenchen (Germany). Abt. fuer Neuroradiologie

    2011-03-15

    Cerebral microangiopathies are a very heterogenous group of diseases characterized by pathological changes of the small cerebral vessels. They account for 20 - 30 % of all ischemic strokes. Degenerative microangiopathy and sporadic cerebral amyloid angiography represent the typical acquired cerebral microangiopathies, which are found in over 90 % of cases. Besides, a wide variety of rare, hereditary microangiopathy exists, as e.g. CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), Fabrys disease and MELAS syndrome (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes). (orig.)

  8. Application of quality control circle management in the prevention of accidental prolapse of gastric tube in patients with cerebral-vascular disease%品管圈管理预防脑血管病患者胃管意外滑脱的效果

    Institute of Scientific and Technical Information of China (English)

    马虹颖; 杨存美; 冯瑞娟

    2014-01-01

    目的:探讨品管圈管理在预防脑血管病患者胃管滑脱中的作用。方法成立品管圈,应用头脑风暴法确立预防胃管滑脱为活动的主题,拟定计划,分析现状,统计绘制柏拉图及鱼骨图分析原因,针对3项主要原因设定目标,制定对策,将实施对策进行效果确认、标准化,修改并制定科室的胃管管理制度。结果实施措施后我科脑血管留置胃管患者拔管率由27.5%(55/200)降低至5.0%(10/200),差异有统计学意义(χ2=27.05,P<0.01);设定的目标值均已达到,目标达成率115%,进步率81%。圈员责任心、自信心、积极性、解决问题的能力、团队凝聚力等方面的能力得到提升。结论品管圈管理研究了影响胃管滑脱的主要因素,制定了切实有效的预防措施,有效解决了胃管滑脱的问题,提高了护士的综合素质,提高了临床护理质量。%Objective To investigate the effect of quality circle control ( QCC ) management in the prevention of accidental prolapse of gastric tube in patients with cerebral -vascular disease .Methods First, we set up the quality control circle , identified the theme , analyzed the current situation and drew the Pareto diagram and fishbone diagram to find out the three main causes .Then we set up the goals and developed strategies .At last we confirmed and standardized the results , modified and formulated the tube management system . Results After applying the QCC management , the extubation rate significantly reduced from 27.5%(55/200) to 5.0%(10/200) (χ2 =27.05,P<0.01), with an achievement rate of 115%and progress rate of 81%.The responsibility, self-confidence, initiative, problem solving ability, team cohesion, communicate and coordinated ability, happiness and quality control means had improved after the application of QCC management . Conclusions The application of QCC management can effectively solve the

  9. 血清血管生长因子浓度变化与急性脑梗死后神经功能康复的关系%Relationship between serum concentration of vascular growth factor and neurological recovery in patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    官俏兵; 张晓玲; 王琰萍; 余波; 杜瑛媛; 万里红

    2013-01-01

    目的:研究血清血管生长因子浓度变化与急性脑梗死后神经功能康复的关系.方法:测定60例急性脑梗死患者发病后不同时间点的血清血小板衍生内皮细胞生长因子(PD-ECGF)与血管内皮生长因子(VEGF)浓度,同步评估美国国立卫生研究院脑卒中量表(NIHSS)评分,并记录脑梗死的体积.另选取同期健康体检人员(否认有高血压病、糖尿病、心、脑血管病等病史)30例作为对照组.结果:脑梗死患者发病后24 h内和第3、7、14天的平均血清PD-ECGF及VEGF浓度均高于相应对照组,并以发病后第7天最高,第14天最低.相应时间点的NIHSS评分差异无统计学意义(F = 1.925,P = 0.126).不同时间点的血清PD-ECGF及VEGF浓度与NIHSS评分无相关性,与脑梗死体积也无相关性.结论:血清PD-ECGF、VEGF浓度在脑梗死后即有升高,参与新生血管形成及脑神经功能恢复,但血清浓度高低并非短期神经功能康复程度和预后的决定因素.%Objective To explore the relationship between serum concentration of vascular growth factor and neurological recovery in patients with acute cerebral infarction (ACI). Methods Serum concentrations of platelet-derived endothelial cell growth factor (PD-ECGF) and vascular endothelial growth factor (VEGF) in 60 patients with ACI were measured, and the scores of national institutes of health stroke scale (NIHSS) were measured at different time points after stroke. Moreover, volumes of infarction at admission were recorded. Results Serum concentrations of PD-ECGF and VEGF in 24 hours and on day 3, 7, 14 in ACI group were significantly higher than those in control group, and reached the peak on day 7 and the trough on day 14. The differences of NIHSS scores at corresponding time points were statistically insignificant (F = 1.925, P = 0.126). The serum concentrations of PD-ECGF and VEGF were irrelevant to NIHSS scores or cerebral infarction volumes at any time point. Conclusions

  10. Buyanghuanwu decoction promotes angiogenesis after cerebral ischemia/reperfusion injury: mechanisms of brain tissue repair.

    Science.gov (United States)

    Zhang, Zhen-Qiang; Song, Jun-Ying; Jia, Ya-Quan; Zhang, Yun-Ke

    2016-03-01

    Buyanghuanwu decoction has been shown to protect against cerebral ischemia/reperfusion injury, but the underlying mechanisms remain unclear. In this study, rats were intragastrically given Buyanghuanwu decoction, 15 mL/kg, for 3 days. A rat model of cerebral ischemia/reperfusion injury was established by middle cerebral artery occlusion. In rats administered Buyanghuanwu decoction, infarct volume was reduced, serum vascular endothelial growth factor and integrin αvβ3 levels were increased, and brain tissue vascular endothelial growth factor and CD34 expression levels were increased compared with untreated animals. These effects of Buyanghuanwu decoction were partially suppressed by an angiogenesis inhibitor (administered through the lateral ventricle for 7 consecutive days). These data suggest that Buyanghuanwu decoction promotes angiogenesis, improves cerebral circulation, and enhances brain tissue repair after cerebral ischemia/reperfusion injury. PMID:27127482

  11. Buyanghuanwu decoction promotes angiogenesis after cerebral ischemia/reperfusion injury:mechanisms of brain tissue repair

    Institute of Scientific and Technical Information of China (English)

    Zhen-qiang Zhang; Jun-ying Song; Ya-quan Jia; Yun-ke Zhang

    2016-01-01

    Buyanghuanwu decoction has been shown to protect against cerebral ischemia/reperfusion injury, but the underlying mechanisms remain unclear. In this study, rats were intragastrically givenBuyanghuanwu decoction, 15 mL/kg, for 3 days. A rat model of cerebral ischemia/reper-fusion injury was established by middle cerebral artery occlusion. In rats administeredBuyanghuanwu decoction, infarct volume was reduced, serum vascular endothelial growth factor and integrinαvβ3 levels were increased, and brain tissue vascular endothelial growth factor and CD34 expression levels were increased compared with untreated animals. These effects ofBuyanghuanwu decoction were partially suppressed by an angiogenesis inhibitor (administered through the lateral ventricle for 7 consecutive days). These data suggest thatBuyanghuanwu de-coction promotes angiogenesis, improves cerebral circulation, and enhances brain tissue repair after cerebral ischemia/reperfusion injury.

  12. Buyanghuanwu decoction promotes angiogenesis after cerebral ischemia/reperfusion injury: mechanisms of brain tissue repair

    Directory of Open Access Journals (Sweden)

    Zhen-qiang Zhang

    2016-01-01

    Full Text Available Buyanghuanwu decoction has been shown to protect against cerebral ischemia/reperfusion injury, but the underlying mechanisms remain unclear. In this study, rats were intragastrically given Buyanghuanwu decoction, 15 mL/kg, for 3 days. A rat model of cerebral ischemia/reperfusion injury was established by middle cerebral artery occlusion. In rats administered Buyanghuanwu decoction, infarct volume was reduced, serum vascular endothelial growth factor and integrin αvβ3 levels were increased, and brain tissue vascular endothelial growth factor and CD34 expression levels were increased compared with untreated animals. These effects of Buyanghuanwu decoction were partially suppressed by an angiogenesis inhibitor (administered through the lateral ventricle for 7 consecutive days. These data suggest that Buyanghuanwu decoction promotes angiogenesis, improves cerebral circulation, and enhances brain tissue repair after cerebral ischemia/reperfusion injury.

  13. Notificações de acidentes de trabalho com material biológico: um estudo no município de Santa Cruz do Sul / RS

    OpenAIRE

    Dayane Diehl; Karini da Rosa; Susimar Souza Rosa; Susane Beatriz Frantz Krug

    2012-01-01

    Trabalhadores da área da saúde estão constantemente expostos ao risco de acidentes ocupacionais envolvendo material biológico. Dessa forma o objetivo do estudo foi elaborar um perfil dos trabalhadores acometidos por acidentes de trabalho com material biológico no município de Santa Cruz do Sul, através do número de notificaçõesrealizadas nos sistemas de informação. Metodologia: Estudo transversal, retrospectivo e de abordagem quantitativa, comcoleta de dados dos anos de 2008 a 2010, em prontu...

  14. Acidentes de transporte terrestre em município da Região Sul do Brasil Road accidents in a city of southern BraziL

    OpenAIRE

    Selma Maffei de Andrade; Maria Helena P. de Mello Jorge

    2001-01-01

    Foram estudadas as características dos acidentes de transporte terrestre, com 3.643 vítimas, ocorridos no primeiro semestre de 1996, em Londrina, PR. O tipo de acidente mais freqüente foi a colisão com carro/caminhonete. A frota de motocicletas foi a que gerou a maior taxa de vítimas (cerca de sete vezes a apresentada por carros/caminhonetes). Maior risco de óbito foi evidenciado entre motociclistas que colidiram com objeto fixo (letalidade de 29,4%), seguido por pedestres atropelados por cam...

  15. Acidente de trabalho, com material biológico, em profissionais de saúde de hospitais públicos do Distrito Federal, Brasil, 2002/2003

    OpenAIRE

    Caixeta Roberta de Betânia; Barbosa-Branco Anadergh

    2005-01-01

    Foi estudada a ocorrência de acidente de trabalho em profissionais de saúde no período de 2002/2003 e a influência das medidas de biossegurança e aceitação de quimioprofilaxia frente ao risco de transmissão ocupacional do HIV. Avaliou-se 570 profissionais de saúde de seis hospitais públicos, selecionados aleatoriamente, do conjunto de hospitais do Distrito Federal, Brasil. Esses profissionais foram questionados quanto ao conhecimento sobre biossegurança, ocorrência de acidente de trabalho, ac...

  16. Perfil epidemiológico de acidentes com material biológico entre estudantes de medicina em um pronto-socorro cirúrgico

    OpenAIRE

    Phillipe Geraldo Teixeira de Abreu Reis; Anna Luiza Driessen; Ana Claudia Brenner Affonso da Costa; Adonis Nasr; Iwan Augusto Collaço; Flávio Daniel Saavedra Tomasich

    2013-01-01

    OBJETIVO: avaliar os acidentes com material biológico entre estudantes de medicina estagiando em um pronto-socorro de trauma e identificar as principais situações relacionadas, causas atribuídas e prevenção. MÉTODOS: estudo com abordagem quantitativa. Os dados foram coletados através de um questionário, aplicado via internet, contendo perguntas fechadas de escolha múltipla, referentes a acidentes com material biológico. A amostra obtida foi 100 estudantes. RESULTADOS: trinta e dois se acident...

  17. Subnotificação de acidentes ocupacionais com material biológico pela enfermagem no bloco cirúrgico

    OpenAIRE

    Amanda Pavinski Alves; Milene Dias Ferreira; Marina Fernandes Prearo; Elucir Gir; Sílvia Rita Marin da Silva Canini

    2013-01-01

    Embora o risco de transmissão de doenças infecciosas para profissionais de saúde devido à exposição a material biológico seja conhecido, estima-se que grande parte dos acidentes seja subnotificada. Os objetivos desta pesquisa foram identificar a taxa e os motivos de subnotificação de acidentes ocupacionais ocorridos com profissionais de enfermagem do bloco cirúrgico de um hospital universitário. Assim, todos os profissionais de enfermagem do bloco cirúrgico que aceitaram participar da pesquis...

  18. Angiopoietin-1 is associated with cerebral vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage

    Directory of Open Access Journals (Sweden)

    Pfausler Bettina

    2011-05-01

    Full Text Available Abstract Background Angiopoietin-1 (Ang-1 and -2 (Ang-2 are keyplayers in the regulation of endothelial homeostasis and vascular proliferation. Angiopoietins may play an important role in the pathophysiology of cerebral vasospasm (CVS. Ang-1 and Ang-2 have not been investigated in this regard so far. Methods 20 patients with subarachnoid hemorrhage (SAH and 20 healthy controls (HC were included in this prospective study. Blood samples were collected from days 1 to 7 and every other day thereafter. Ang-1 and Ang-2 were measured in serum samples using commercially available enzyme-linked immunosorbent assay. Transcranial Doppler sonography was performed to monitor the occurrence of cerebral vasospasm. Results SAH patients showed a significant drop of Ang-1 levels on day 2 and 3 post SAH compared to baseline and HC. Patients, who developed Doppler sonographic CVS, showed significantly lower levels of Ang-1 with a sustained decrease in contrast to patients without Doppler sonographic CVS, whose Ang-1 levels recovered in the later course of the disease. In patients developing cerebral ischemia attributable to vasospasm significantly lower Ang-1 levels have already been observed on the day of admission. Differences of Ang-2 between SAH patients and HC or patients with and without Doppler sonographic CVS were not statistically significant. Conclusions Ang-1, but not Ang-2, is significantly altered in patients suffering from SAH and especially in those experiencing CVS and cerebral ischemia. The loss of vascular integrity, regulated by Ang-1, might be in part responsible for the development of cerebral vasospasm and subsequent cerebral ischemia.

  19. Isquemia cerebral transitoria y riesgo de infarto cerebral isquémico

    Directory of Open Access Journals (Sweden)

    Luis Guillermo Rosales-Bravo

    2006-03-01

    Full Text Available La enfermedad vascular cerebral es la principal causa de hospitalización neurológica en el mundo. Costa Rica no es la excepción; en nuestros hospitales cada día es más frecuente el número de pacientes que ingresan con infartos cerebrales isquémicos. Esta común enfermedad obedece a la prevalencia de enfermedades crónicas como la hipertensión arterial, diabetes mellitus, dislipidemias, tabaquismo y la alta expectativa de vida de los costarricenses, todos considerados factores de riesgo. Aproximadamente un 80% de los infartos cerebrales son isquémicos secundarios a la oclusión arterial aguda de un territorio vascular específico; el restante 20% corresponde a la variante hemorrágica. Las secuelas neurológicas secundarias a esta entidad son la principal causa de discapacidad crónica en los pacientes y conllevan una alta morbilidad y mortalidad. Aunque muchos sufren el infarto cerebral isquémico en forma aguda, otro grupo de pacientes experimenta uno o varios episodios previos de isquemia cerebral transitoria, lo cual los pone en riesgo de sufrir un infarto cerebral isquémico durante un periodo corto, es decir, son pacientes vulnerables. Esta revisión pretende actualizar los conocimientos médicos, especialmente para aquellos que trabajan en la atención primaria y en los servicios de urgencias hospitalarias, que reconozcan a este grupo de pacientes y les brinden la atención médica necesaria para de prevenir un infarto cerebral isquémico. La isquemia cerebral transitoria debe ser considerada como una emergencia neurológica.

  20. Branding of vascular surgery.

    Science.gov (United States)

    Perler, Bruce A

    2008-03-01

    The Society for Vascular Surgery surveyed primary care physicians (PCPs) to understand how PCPs make referral decisions for their patients with peripheral vascular disease. Responses were received from 250 PCPs in 44 states. More than 80% of the respondents characterized their experiences with vascular surgeons as positive or very positive. PCPs perceive that vascular surgeons perform "invasive" procedures and refer patients with the most severe vascular disease to vascular surgeons but were more than twice as likely to refer patients to cardiologists, believing they are better able to perform minimally invasive procedures. Nevertheless, PCPs are receptive to the notion of increasing referrals to vascular surgeons. A successful branding campaign will require considerable education of referring physicians about the totality of traditional vascular and endovascular care increasingly provided by the contemporary vascular surgical practice and will be most effective at the local grassroots level.

  1. Effects of treadmill training on matrix metalloproteinases-2 and vascular endotheliar growth factor in ischemic brain of rats after cerebral ischemia-reperfusion%跑台训练对大鼠脑缺血再灌注后脑组织基质金属蛋白酶-2和血管内皮生长因子表达的影响

    Institute of Scientific and Technical Information of China (English)

    马跃文; 强琳

    2012-01-01

    Objective: To study the effects of treadmill training on the recovery of neurological function and the expression of MMP-2 and VEGF in ischemic brain of rats after cerebral ischemia-reperfusion. Method: A total of thirty-five male adult Wistar rats were given cerebral ischemia-reperfusion and were randomly divided into sham-operated group, control group and exercise group, with treadmill running. Neurological function was measured at the 24h after the operation, the 3rd, the 7th and the 14th day after the beginning of exercise respectively. RT-PCR was used to detect the expression of MMP-2 and VEGF in the ischemic brain at the 3rd, 7th and 14th day. Result: Compared with those in the control group, the behavior scores in exercise group was much lower at the 7th and 14th day (P < 0.05). MMP-2 expression in exercises group was higher than in the control group at the 7th and 14th day (P<0.05). The expression of VEGF in the exercise group was greater than that in the control group at all points (P < 0.05). Conclusion: The expression of MMP-2 and VEGF in the brain ischemic area can be improved through treadmill training. It can promote recovery of neurological function by developing neurogenesis and promoting vascularization after cerebral infarction.%目的:探讨跑台训练对大鼠脑缺血再灌注神经功能恢复和缺血脑组织中MMP-2和VEGF表达的影响.方法:用线栓法制作Wistar大鼠大脑中动脉梗死再灌注模型,35只大鼠随机分为假手术组、跑台训练组和手术对照组.跑台训练和手术对照组又分为跑3天、跑7天、跑14天3个亚组,各业组及假手术组每组5只大鼠.跑台组于术后第3天开始给予跑台训练,假手术组及手术对照组不予跑台训练.于跑3天、跑7天、跑14天3个时间点进行神经功能评估后处死大鼠.采用RT-PCR技术测定缺血区脑组织中MMP-2及VEGF的水平.结果:跑台训练组在跑7天、跑14天神经功能评分明显低于对照组(P<0.05).

  2. Changes and Its Clinical Significance of Erythrocyte Immune Function and T Lymphocyte Subsets in Patients with Acute Cerebral Vascular Disorder%急性脑血管病患者红细胞免疫功能和T淋巴细胞亚群变化的初步研究

    Institute of Scientific and Technical Information of China (English)

    苗建亭; 雷革胜; 李柱一; 王者晋

    2001-01-01

    目的 探讨急性脑血管病患者红细胞免疫功能和T淋巴细胞亚群的变化及其临床意义。方法 应用免疫粘附酵母菌花环法和流式细胞仪(FCM)直接免疫荧光染色法,检测79例脑血管病患者(脑梗死41例,脑出血38例)外周血RBC-C3bRR和RBC-ICR以及T淋巴细胞亚群,并进行相关分析。结果 急性期脑梗死组和脑出血组RBC-C3bRR、CD3+、CD4+和CD4+/CD8+均明显低于对照组,RBC-ICR则显著增高。不同损伤部位对细胞免疫功能的影响为基底节区>脑干>额叶>顶叶>颞叶>小脑>枕叶,且出血量或梗死面积越大,机体细胞免疫功能下降越显著。RBC-C3bRR与CD4+/CD8+呈显著正相关。结论 脑血管病患者发病后存在严重的红细胞和T细胞免疫功能低下和平衡失调,病变的性质(梗死或出血)不是其决定性因素,而可能取决于脑损伤的部位和程度。%Objective The changes and its clinical significance oferythrocyte immune function and T lymphocyte subsets were studied in patients with acute cerebral vascular disorders(ACVD). Methods Erythrocyte immune function(including RBC-C3bRR and RBC-ICR) and T lymphocyte subsets(including CD3+、CD4+、CD8+、CD4+/CD8+) were measured in 79 ACVD patients by the immune adherence rosette and the direct immunofluroscent staining technique. Results RBC-C3bRR、CD3+、CD4+ and CD4+/CD8+ decreased markedly while RBC-ICR increased relatively during acute period of CVD as compared with normal group. The effects on cell immune function vary with different cerebral focal lesions as in the following order of degree : basic ganglia >brain stem>frontal lobe > parietal lobe > temporal lobe > cerebellum > occipital lobel.Cell immune function declined markedly while hemorrhage volume or infarct area were more severe.There was a positive relationship between RBC-C3bRR and CD4+/CD8+. Conclusions Severe erythrocyte and T lymphocyte immune functional decline and disbalance were observed

  3. Acidente com material biológico: uma abordagem a partir da análise das atividades de trabalho

    OpenAIRE

    Sandra Donatelli; Rodolfo Andrade de Gouveia Vilela; Ildeberto Muniz de Almeida; Manoela Gomes Reis Lopes

    2015-01-01

    Trata-se de estudo qualitativo feito em hospital universitário, cujo objetivo foi analisar o trabalho de auxiliares e técnicos de enfermagem, categoria mais numerosa entre os profissionais de saúde e mais sujeita à incidência de acidentes de trabalho. Este hospital conta com um pouco mais de 2.000 profissionais de enfermagem. Foram utilizados dois métodos de análise. 1) A Análise Coletiva do Trabalho (ACT), que consiste em reuniões com pequenos grupos de trabalhadores explicando seu trabalho....

  4. Conduta pós-acidente de trabalho no cuidado às pessoas com HIV/Aids

    OpenAIRE

    Mariana Vieira Villarinho; Maria Itayra Padilha

    2015-01-01

    RESUMOObjetivo:identificar condutas pós-acidente de trabalho pelos profissionais da saúde no cuidado às pessoas com HIV/Aids.Método:estudo descritivo qualitativo com perspectiva sócio-histórica, (1986-2006) realizado em um hospital referência em doenças infectocontagiosas do Estado de Santa Catarina. Para a coleta de dados, utilizou-se entrevista, a partir da História Oral com 23 trabalhadores da saúde e para o tratamento dos dados a análise de conteúdo de Bardin foi utilizado.Resultados:emer...

  5. Mortalidade devido a acidentes de bicicletas em Pernambuco, Brasil Mortality due to bicycle accidents in Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Reginaldo Inojosa Carneiro Campello

    2013-05-01

    Full Text Available O artigo tem por objetivo analisar os casos de morte nos acidentes com bicicleta ocorridos em Pernambuco entre 2001 e 2010. Este estudo quantitativo analisou dados secundários. A amostra consistiu de todas as Declarações de Óbitos registradas no Sistema de Informação de Mortalidade do Banco de Dados do Sistema Único de Saúde que relataram acidentes de bicicleta entre 2001 e 2010. Medidas descritivas foram determinadas para todas as variáveis. As sociodemográficas foram cruzadas com a causa básica de morte em busca de correlação estatística. Em Pernambuco, no citado sistema de informação, foram registradas 517 Declarações de Óbitos decorrentes de acidentes de bicicleta, sendo nestes sinistros a participação mais frequente de homens, entre 25-59 anos, pardos, solteiros e de escolaridade ignorada. A idade média foi de 36,82 anos (desvio padrão = 17,026, sendo a idade mínima e a máxima, respectivamente, 4 e 86 anos. Os achados apontam para a necessidade da criação de infraestrutura adequada e de medidas legais efetivas para prevenir acidentes de tráfego envolvendo este tipo de veículo, apoiando-se na evidência de distribuição de casos na maioria dos municípios de Pernambuco.The scope of this paper was to conduct a quantitative analysis of deaths resulting from bicycle accidents in the state of Pernambuco by studying secondary data between 2001 and 2010. The sample consisted of all the Deaths recorded in the Mortality Information System of the Unified Health System Database that reported bicycle accidents between 2001 and 2010. Descriptive measures were determined for all variables. Socio-demographic variables were paired with the basic cause of death in order to find a statistical correlation. In Pernambuco, the aforementioned information system recorded 517 deaths resulting from bicycle accidents, with greater frequency in men between 25 and 59 years of age, Afro-Brazilians, single and of unknown schooling. The mean

  6. Modeling cerebral blood flow during posture change from sitting to standing

    DEFF Research Database (Denmark)

    Ottesen, Johnny T.; Olufsen, M.; Tran, H.T.

    2004-01-01

    extremities, the brain, and the heart. We use physiologically based control mechanisms to describe the regulation of cerebral blood flow velocity and arterial pressure in response to orthostatic hypotension resulting from postural change. To justify the fidelity of our mathematical model and control......Abstract Hypertension, decreased cerebral blood flow, and diminished cerebral blood flow velocity regulation, are among the first signs indicating the presence of cerebral vascular disease. In this paper, we will present a mathematical model that can predict blood flow and pressure during posture...

  7. Effects of electroacupuncture on learning and memory abilities and the apoptosis of cerebral cells in rats with vascular dementia%电针对血管性痴呆大鼠学习记忆能力和脑组织细胞凋亡的影响

    Institute of Scientific and Technical Information of China (English)

    赖新生; 王黎

    2004-01-01

    背景:血管性痴呆(vascular dementia,VD)目前尚缺乏特异性的治疗方法,但有效地消除危险因素,积极预防脑血管疾病,或对已发脑血管疾病的患者预防其复发、进展和并发症,对防止VD的发生将起到重要的作用.而探明针灸治疗VD的获效机制是VD治疗研究的热点之一.目的:观察电针对实验性,VD大鼠学习记忆能力和脑组织细胞凋亡的影响.设计:随机对照实验研究.单位:广州中医药大学针灸推拿学院与基础医学院.材料:成年健康SD大鼠60只,雌雄各半,体质量200~250 g,由广州中医药大学实验动物研究中心提供.方法:在本校动物实验中心选用健康SD大鼠建立4-血管阻断VD模型.用Morris水迷宫测定大鼠定位航行试验和空间探索试验,并用Tunel法检测鼠脑皮质和海马细胞凋亡表达.结果:在定位航行实验中,模型大鼠潜伏期为(58.08±38.77)s,假手术组为(26.50±29.4)s,模型大鼠潜伏期显著延长;在空间探索试验中,模型大鼠在原平台象限跨越平台次数与其余三个象限差异无显著意义;其顶叶皮层凋亡细胞数为41.60±3.71,海马凋亡细胞数为35.83±7.11.电针组定位航行试验的潜伏期为(29.89±32.62)s;在空间探索试验中,在原平台象限跨越平台次数显著多于其余三个象限,与假手术组比较差异无显著意义;顶叶皮层的凋亡细胞数为12.84±5.44,海马为11.30 ±4.16,其细胞凋亡数目明显少于模型组.结论:电针能改善VD大鼠学习记忆能力,有拮抗脑组织细胞凋亡的作用.%BACKGROUND: Although a specific and satisfactory therapeutic method for vascular dementia(VD) has not been developed, it is important to prevent VD by effectively avoiding risk factors, preventing cerebrovascular accident (CVA)or preventing the recurrence, development and complications in patients with CVA. Exploring the effective mechanism for VD treatment with electroacupuncture method is one of the hot issues

  8. Angiographic findings in 2 children with cerebral paragonimiasis with hemorrhage.

    Science.gov (United States)

    Chen, Zhi; Chen, Jingyu; Miao, Hongpin; Li, Fei; Feng, Hua; Zhu, Gang

    2013-05-01

    Hemorrhagic events associated with cerebral paragonimiasis are not rare, especially in children and adolescents; however, angiographic evidence of cerebrovascular involvement has not been reported. The authors describe angiographic abnormalities of the cerebral arteries seen in 2 children in whom cerebral paragonimiasis was associated with hemorrhagic stroke. The patients presented with acute intracerebral and subarachnoid hemorrhage. Angiography revealed a beaded appearance and long segmental narrowing of arteries, consistent with arteritis. In both patients, involved vessels were seen in the area of the hemorrhage. The vascular changes and the hemorrhage, together with new lesions that developed close to the hemorrhage and improved after praziquantel treatment, were attributed to paragonimiasis. Further study of the frequency and mechanism of hemorrhagic cerebrovascular complications associated with cerebral paragonimiasis is needed.

  9. Acute cerebral paragonimiasis presenting as hemorrhagic stroke in a child.

    Science.gov (United States)

    Chen, Zhi; Zhu, Gang; Lin, Jiangkai; Wu, Nan; Feng, Hua

    2008-08-01

    A hemorrhagic stroke in children is rarely secondary to cerebral paragonimiasis. We describe a 9-year-old boy in whom an intracerebral hemorrhage was the leading clinical indication of acute cerebral paragonimiasis. He was hospitalized because of a sudden onset of headache, right hemiparesis, and dysarthria. A computed tomography scan revealed an intracerebral hemorrhage in the left parietal lobe. Magnetic resonance angiography did not confirm any vascular abnormalities at the location of the hematoma. Four weeks later, he presented with right hemiparesis again, and fever. A diagnosis of cerebral paragonimiasis was based on repeated magnetic resonance imaging of the brain and an enzyme-linked immunosorbent assay for paragonimiasis. The patient gradually recovered with praziquantel treatment. Cerebral paragonimiasis should be considered in the differential diagnosis of hemorrhagic strokes in children in areas where paragonimiasis is epidemic.

  10. Cerebral large vessel vasculitis in systemic lupus erythematosus.

    Science.gov (United States)

    Böckle, B C; Jara, D; Aichhorn, K; Junker, D; Berger, T; Ratzinger, G; Sepp, N T

    2014-11-01

    Neuropsychiatric systemic lupus erythematosus (NPSLE) is defined by involvement of the central nervous system in systemic lupus erythematosus (SLE), with a wide range of both neurological and psychiatric manifestations. Although its aetiopathogenesis is not fully elucidated, NPSLE seems to be a consequence of cerebral vascular pathology including thromboembolism, small-vessel vasculopathy and, in rare cases, true vasculitis. Cerebral vasculitis is rare, and cerebral large-vessel vasculitis in SLE is even more unusual. We report the case of a female patient with the diagnosis of SLE. She presented with stroke-like symptoms, headache and vertigo, and palpable purpura on her legs. Further investigations revealed that she suffered from both vasculitis of the cerebral large vessels and coexisting cutaneous small-vessel vasculitis. PMID:24969082

  11. Study on the relationship between CSF LA levels and CT scanning or clinical manifestation in the patients with acute cerebral vascular diseases%脑卒中患者脑脊液乳酸水平与CT及临床的相关性研究

    Institute of Scientific and Technical Information of China (English)

    侯群; 陈眉; 王珏; 孙岩

    2001-01-01

    目的 探讨脑卒中患者脑脊液(CSF)乳酸(LA)浓度与CT及临床的关系及其临床意义。方法 以发病3天以内的24例基底节出血患者、9例脑叶出血患者、16例脑梗死患者为观察对象,以21例腔隙性脑梗死患者为对照。采用等速电泳法测定CSFLA浓度。按CT检查结果及多田公式计算出(缺)血量、按Glasgow昏迷观察量表计算入院GCS积分、按改良Edinburh-Scandinavia卒中量表计算入、出院RESSS积分。结果 在基底节出血组,CSFLA浓度明显高于脑梗死组及对照组(P<0.05或0.01),入院GCS积分较低,入、出院RESSS积分较高,有的组间差异有统计学意义;CSFLA浓度与血肿量,入院GCS积分及出院RESSS积分间的相关系数为0.455、-0.577、0.547(P<0.05);CSFLA浓度≥2.50mmol/L患者的血肿量,入、出院RESSS积分较高,入院GCS积分较低,其中出院RESSS积分间的差异有显著性意义。对脑叶出血、脑梗死患者未发现特殊规律。结论 测定CSFLA浓度对基底节出血患者可作为判断疾病严重程度及预后的指标,对脑叶出血、脑梗死患者的临床意义尚需进一步研究。%Objective To explore the relationship between the cerebrospinalfluid(CSF)lactic acid(LA)levels and the CT scanning or the clinical manifestation in the patients with acute cerebral vascular diseases and its clinical meanings.Methods All the patients chosen attacked in no more than 3 days.Among them,there were 24 patients with basal ganglion hemorrhage(BGH),9 patients with cerebral lobar hemorrhage(CLH),and 16 patients with cerebral infarction(CI) as observing cases.21 patients with cerebral lacuna infarction were as control.The CSF LA levels were determined using isotachphoresis.The amount of bleeding or ischemia was counted based on CT scanning and Duo Tian formula.The GCS score at admission and the RESSS scores at admission or discharge were summed up according to the Glasgow Coma Scale or the

  12. Cerebral angiography in leptomeningitis and cerebritis

    International Nuclear Information System (INIS)

    This is a report of the cerebral angiographic findings in cases of meningitis and cerebritis. Fifty-nine patients, 38 of whom were under 1 year of age, underwent cerebral angiography by means of femoral catheterization. All the patients had signs of increased intracranial pressure, seizures, focal cerebral signs, positive transillumination of the head, and or abnormal brain scan findings. A few patients who did not respond to systemic antibiotics as was expected were also evaluated by means of cerebral angiography. The following characteristic angiographic findings were observed in 18 cases of active meningitis: (1) A hasy appearance around the arteries (halo formation) between the late arterial and capillary phases. (2) Narrowing of the arteries in the basal cistern. This sometimes extended to the peripheral arteries. (3) Irregular caliber following the narrowing of arteries (in few cases). (4) Circulation time so slow that veins could be seen in the late arterial phase. (5) Halo formation around the anterior chroidal artery and the clear appearance of the choroid plexus in the venous phase (when the infectious process reached the choroid plexus). Cerebritis could be identified on the angiograms by two signs: (1) local swelling of the brain (mainly the temporal lobe) and (2) staining around the veins without any abnormal signs in the arterial phase (laminar staining). In conclusion, angiography is a meaningful test by which to determine the phase of meningitis and cerebritis. These two conditions should be treated based on valid information obtained by means of CSF examinations and neuroradiological tests, especially CT scan and cerebral angiography. (author)

  13. Collagen vascular disease

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/001223.htm Collagen vascular disease To use the sharing features on this page, ... were previously said to have "connective tissue" or "collagen vascular" disease. We now have names for many of many ...

  14. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

    OpenAIRE

    Joutel, A.; Monet-Lepretre, M.; Gosele, C.; Baron-Menguy, C.; Hammes, A.; Schmidt, S.; Lemaire-Carrette, B.; Domenga, V.; Schedl, A; Lacombe, P.; Huebner, N.

    2010-01-01

    Cerebral ischemic small vessel disease (SVD) is the leading cause of vascular dementia and a major contributor to stroke in humans. Dominant mutations in NOTCH3 cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic archetype of cerebral ischemic SVD. Progress toward understanding the pathogenesis of this disease and developing effective therapies has been hampered by the lack of a good animal model. Here, we report the developmen...

  15. Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

    OpenAIRE

    Han, Byung Hee; Zhou, Meng-liang; Johnson, Andrew W; Singh, Itender; Liao, Fan; Vellimana, Ananth K.; Nelson, James W.; Milner, Eric; Cirrito, John R.; Basak, Jacob; Yoo, Min; Dietrich, Hans H.; Holtzman, David M.; Zipfel, Gregory Joseph

    2015-01-01

    One of the hallmarks of Alzheimer’s disease (AD) is cerebral amyloid angiopathy (CAA), which is a strong and independent risk factor for cerebral hemorrhage, ischemic stroke, and dementia. However, the mechanisms by which CAA contributes to these conditions are poorly understood. Results from the present study provide strong evidence that vascular oxidative stress plays a causal role in CAA-induced cerebrovascular dysfunction, CAA-induced cerebral hemorrhage, and CAA formation, itself. They a...

  16. Cerebral CT of ischaemic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Aulich, A.

    1981-11-25

    The diagnosis of stroke must first be established by clinical examination. CT has proved useful for confirmation of the diagnosis and provides a global intracranial picture of morphological changes in cerebral vascular diseases. A hemorrhage can be recognized with certainty at the first CT examination as the cause of the stroke, but in the detection of a lesion due to ischemia an important role is played by the correct choice of the time of examination, and in some cases also of the check-up with contrast medium. The differential diagnosis between infarct in the acute stage and encephalitis or gliomas of low-grade malignity can be difficult. A decision can often only be made after a series of examinations. Postmalacial conditions are often difficult to differentiate from defects due to other causes, such as hemorrhage, head injury, postoperative states and after encephalitis. A knowledge of the anamnesis and the clinical findings is indispensable for CT evaluation. In assessing the prognosis before vascular surgery on the extracranial brain-supplying vessels the performance of a CT examination should be advised. A warning is given against the use of CT as a screening method.

  17. Vascular grading of angiogenesis

    DEFF Research Database (Denmark)

    Hansen, S; Grabau, D A; Sørensen, Flemming Brandt;

    2000-01-01

    was moderately reproduced (kappa = 0.59). Vascular grade was significantly associated with axillary node involvement, tumour size, malignancy grade, oestrogen receptor status and histological type. In univariate analyses vascular grade significantly predicted recurrence free survival and overall survival for all...... patients (P analysis showed that vascular grading contributed with independent prognostic value in all patients (P

  18. Effect of Electromagnetic Pulse Exposure on Brain Micro Vascular Permeability in Rats

    Institute of Scientific and Technical Information of China (English)

    GUI-RONG DING; KANG-CHU LI; XIAO-WU WANG; YONG-CHUN ZHOU; LIAN-BO QIU; JUAN TAN; SHENG-LONG XU; GUO-ZHEN GUO

    2009-01-01

    Objective To observe the effect of electromagnetic pulse (EMP) exposure on cerebral micro vascular permeability in rats.Methods The whole-body of male Sprague-Dawley rats were exposed or sham exposed to 200 pulses or 400 pulses (1 Hz) of EMP at 200 kV/m.At 0.5,1,3,6,and 12 h after EMP exposure,the permeability of cerebral micro vascular was detected by transmission electron microscopy and immunohistochemistry using lanthanum nitrate and endogenous albumin as vascular tracers,respectively. Results The lanthanum nitrate tracer was limited to the micro vascular lumen with no lanthanum nitrate or albumin tracer extravasation in control rat brain.After EMP exposure,the lanthanum nitrate ions reached the tight junction,basal lamina and pericapillary tissue.Similarly,the albumin immunopositive staining was identified in pericapillary tissue.The changes in brain micro vascular permeability were transient,the leakage of micro vascular vessels appeared at 1 h,and reached its peak at 3 h,and nearly recovered at 12 h,after EMP exposure.In addition,the leakage of micro vascular was more obvious after exposure of EMP at 400 pulses than after exposure of EMP at 200 pulses. Conclusion Exposure to 200 and 400 pulses (1 Hz) of EMP at 200 kV/m can increase cerebral micro vascular permeability in rats,which is recoverable.

  19. Computed tomography in spastic cerebral palsy

    Energy Technology Data Exchange (ETDEWEB)

    Pedersen, H.; Taudorf, K.; Melchior, J.C.

    1982-09-01

    Eighty-three children with spastic cerebral palsy (CP) were examined with cranial CT. In 56 cases the CT findings were abnormal. The most frequent abnormality was atrophy, present in 44 patients. The frequency of pathologic CT increased with severity of the CP. Patients with CP of postnatal aetiology more often had abnormal CT than patients with other known causes. Pathologic CT findings were seen more often in patients with seizures than in patients without. Infarctions and hemiatrophy were much more frequent in patients with hemiplegia than in patients with other types of spastic CP. A special kind of central atrophy, called isolated atrophy around the cella media, is described. This condition was seen in 20% of cases, most often in hemi- and paraplegic patients. Early infarctions in the border areas between the vascular territories of the internal carotid and the posterior cerebral artery may be the reason for this kind of atrophy.

  20. Cerebral angiographic findings in thromboangiitis obliterans

    Energy Technology Data Exchange (ETDEWEB)

    No, Young J.; Lee, Eun M.; Kim, Jong S. [University of Ulsan, Department of Neurology, Asan Medical Center, Song Pa, PO Pox 145, Seoul (Korea); Lee, Deok H. [University of Ulsan, Department of Neuroradiology, Asan Medical Center, Song Pa, PO Pox 145, Seoul (Korea)

    2005-12-01

    Transient ischemic attacks (TIAs) or ischemic stroke may complicate thromboangiitis obliterans (TAO). However, there has been debate regarding the mechanism of ischemic stroke in TAO. We report the case of a patient with TAO who developed repeated TIAs. An angiogram showed multiple alternative areas of arterial occlusions in the distal segments of both middle cerebral arteries. Extensive collateral vessels around the occluded segment were also observed, which resembled the ''tree root'' or ''corkscrew'' vessels described in the peripheral arteries in TAO. Our patient illustrates that cerebral manifestations of TAO may occur with vascular changes that are identical with those encountered in the limb arteries in TAO. (orig.)

  1. Esquistossomose mansônica cerebral

    Directory of Open Access Journals (Sweden)

    Andyr Nazareth Andrade

    1989-03-01

    Full Text Available Relata-se um caso de neuroesquistossomose (NE mansônica cerebral forma granulomatosa pseudotumoral de localização no córtex do lobo parietal esquerdo determinando, hemiparesia direita e síndrome de hipertensão intracraniana, diagnosticado por biópsia cirúrgica. Fatores vasculares e imunológicos são considerados na fisiopatogenia da NE. Enfatiza-se a necessidade de melhor se estudar, diagnosticar e divulgar as várias formas de envolvimento do SN na esquistossomose mansônica, que parece ser mais freqüente do que se julga atualmente. O comprometimento cerebral com repercussão clínica nesta doença é raro, sendo a forma pseudotumoral limitada a poucos casos descritos na literatura.

  2. How to Prevent Vascular Disease

    Science.gov (United States)

    ... our CEO Board of Directors Scientific Advisory Board History of Vascular Cures Impact Contact Us Vascular Disease What is Vascular Disease? Education and Awareness Vascular Diseases Abdominal Aortic Aneurysm Aortic ...

  3. Statins and cerebral hemodynamics

    Science.gov (United States)

    Giannopoulos, Sotirios; Katsanos, Aristeidis H; Tsivgoulis, Georgios; Marshall, Randolph S

    2012-01-01

    HMG-CoA reductase inhibitors (statins) are associated with improved stroke outcome. This observation has been attributed in part to the palliative effect of statins on cerebral hemodynamics and cerebral autoregulation (CA), which are mediated mainly through the upregulation of endothelium nitric oxide synthase (eNOS). Several animal studies indicate that statin pretreatment enhances cerebral blood flow after ischemic stroke, although this finding is not further supported in clinical settings. Cerebral vasomotor reactivity, however, is significantly improved after long-term statin administration in most patients with severe small vessel disease, aneurysmal subarachnoid hemorrhage, or impaired baseline CA. PMID:22929438

  4. Acute and chronic head-down tail suspension diminishes cerebral perfusion in rats

    Science.gov (United States)

    Wilkerson, M. Keith; Colleran, Patrick N.; Delp, Michael D.

    2002-01-01

    The purpose of this study was to test the hypothesis that regional brain blood flow and vascular resistance are altered by acute and chronic head-down tail suspension (HDT). Regional cerebral blood flow, arterial pressure, heart rate, and vascular resistance were measured in a group of control rats during normal standing and following 10 min of HDT and in two other groups of rats after 7 and 28 days of HDT. Heart rate was not different among conditions, whereas mean arterial pressure was elevated at 10 min of HDT relative to the other conditions. Total brain blood flow was reduced from that during standing by 48, 24, and 27% following 10 min and 7 and 28 days of HDT, respectively. Regional blood flows to all cerebral tissues and the eyes were reduced with 10 min of HDT and remained lower in the eye, olfactory bulbs, left and right cerebrum, thalamic region, and the midbrain with 7 and 28 days of HDT. Total brain vascular resistance was 116, 44, and 38% greater following 10 min and 7 and 28 days of HDT, respectively, relative to that during control standing. Vascular resistance was elevated in all cerebral regions with 10 min of HDT and remained higher than control levels in most brain regions. These results demonstrate that HDT results in chronic elevations in total and regional cerebral vascular resistance, and this may be the underlying stimulus for the HDT-induced smooth muscle hypertrophy of cerebral resistance arteries.

  5. Estudo espacial da mortalidade por acidentes de motocicleta em Pernambuco Estudio espacial de la mortalidad de accidentes de motocicleta en Pernambuco, Noreste de Brasil Spatial study of mortality in motorcycle accidents in the State of Pernambuco, Northeastern Brazil

    OpenAIRE

    Paul Hindenburg Nobre de Vasconcelos Silva; Maria Luiza Carvalho de Lima; Rafael da Silveira Moreira; Wayner Vieira de Souza; Amanda Priscila de Santana Cabral

    2011-01-01

    OBJETIVO: Analisar a distribuição espacial da mortalidade por acidentes de motocicleta no estado de Pernambuco. MÉTODOS: Estudo ecológico de base populacional, usando os dados de mortalidade por acidentes de motocicletas ocorridos de 01/01/2000 a 31/12/2005. As unidades de análise foram municípios. Para a análise da distribuição espacial dos óbitos foram construídos coeficientes médios de mortalidade, tendo como numerador os óbitos por acidentes de motocicletas registrados no Sistema de Infor...

  6. A mulher e o acidente de trânsito: caracterização do evento em Maringá, Paraná Women and traffic accidents: characterization of occurrences in Maringá, Paraná

    OpenAIRE

    Pedro Paulo Davantel; Sandra Marisa Pelloso; Maria Dalva de Barros Carvalho; Nelson Luis Batista de Oliveira

    2009-01-01

    Os acidentes de trânsito são atualmente a primeira causa de mortalidade no conjunto de causas externas entre as mulheres. A mulher atual, pelas mudanças em seu papel na sociedade, vem se expondo a novos riscos. Este estudo teve como objetivo caracterizar a mulher envolvida em acidente de trânsito, assim como os eventos. Foi realizado um estudo transversal, com dados secundários obtidos nos Boletins de Ocorrência de Acidente de Trânsito - BOAT, do 4º Batalhão da Polícia Militar de Maringá, Set...

  7. Acidente com material biológico no atendimento pré-hospitalar móvel: realidade para trabalhadores da saúde e não saúde

    OpenAIRE

    Anaclara Ferreira Veiga Tipple; Elisangelo Aparecido Costa Silva; Sheila Araújo Teles; Katiane Martins Mendonça; Adenícia Custódia Silva e Souza; Dulcelene de Sousa Melo

    2013-01-01

    Estudo analítico transversal, com objetivos de identificar a prevalência e caracterizar os acidentes com material biológico entre profissionais do Atendimento Pré-Hospitalar (APH) e comparar os comportamentos de risco adotados entre os grupos saúde e não saúde que podem influenciar na ocorrência e na gravidade destes acidentes. Dados foram obtidos por meio de questionário aplicado a todos os trabalhadores do APH de Goiânia - GO. Verificou-se alta prevalência de acidentes envolvendo material b...

  8. 踝臂指数对老年高血压合并下肢动脉病变患者发生心脑血管病风险的预测价值%Assessment of peripheral arterial disease in elderly hypertensive patients and risk prediction of cardio-cerebral vascular disease by ankle-brachial index

    Institute of Scientific and Technical Information of China (English)

    沈丹; 曹萍; 王桦; 刘珍丽

    2012-01-01

    目的 探讨踝臂指数(ABI)对老年高血压合并下肢动脉病变(PAD)患者发生心脑血管病变风险的预测价值.方法 回顾性分析老年高血压病患者285例,按照ABI值分为高血压合并PAD组(PAD组,55例)和高血压未合并PAD组(非PAD组,230例),比较2组间臂踝脉搏波传导速度(baPWV)及各种心脑血管病危险因素的差异.结果 与非PAD组比较,PAD组收缩压(SBP)、脉压(PP)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)[Lp(a)]、血尿酸(UA)、C反应蛋白(CRP)、糖化血红蛋白(HbA1c)以及baPWV值均明显增加(P<0.05,或P<0.01);且发生冠心病、脑梗死的风险分别增高3.17倍(95%CI 1.29~7.76)和5.57倍(95%CI 2.15~14.44);相关分析显示,ABI与年龄(r=-0.273,P=0.025)、PP(r=-0.230,P=0.034)、Lp(a)(r=-0.361,P=0.002)、UA(r=-0.210,P=0.046)、CRP(r=-0.311,P=0.030)、HbA1c(r=-0.272,P=0.017)、baPWV(r=-0.291,P=0.018)均呈负相关.Logistic回归分析提示,年龄、SBP、PP及Lp(a)是PAD的独立危险因素.结论 ABI可评估老年高血压患者下肢动脉病变的严重程度,并预测其心脑血管疾病的发生风险.%Objective To investigate whether the ankle-brachial index ( ABI ) can assess peripheral arterial disease ( PAD ) in elderly hypertensive patients and predict the risk of cardio-cerebral vascular diseases. Methods The data of 285 elderly hypertensive patients was retrospectively reviewed and analyzed. They were diagnosed as hypertension with PAD ( n = 55 ) or without PAD ( none-PAD, n = 230 ) according to ABI criteria. Brachial-ankle pulse wave velocity ( baPWV ) and various cardiovascular risk factors were compared between the two groups. Results The prevalence of PAD in elderly hypertensive patients was 19. 3% . Compared with patients without PAD, the levels of systolic blood pressure ( SBP ), pulse pressure ( PP ), low density lipoprotein-cholesterol ( LDL-C ), lipoprotein (a)[Lp(a)], uric acid ( UA ), C-reactive protein ( CRP ), HbAl c and ba

  9. Caracterização dos acidentes com máquinas agrícolas em rodovias federais no estado do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Deivielison Ximenes Siqueira Macedo

    2015-01-01

    Full Text Available Grande parte da área plantada do Rio Grande do Sul é destinada para o cultivo de culturas que necessitam do uso de máquinas agrícolas para seus tratos culturais. Todavia, o uso inadequado dessas máquinas propicia um maior número de acidentes, principalmente pela circulação das máquinas nas rodovias. Objetivou-se no trabalho caracterizar os acidentes com máquinas agrícolas ocorridos em rodovias federais no estado do Rio Grande do Sul, dando ênfase aos seus principais indicadores. Os registros dos acidentes foram obtidos através do Boletim de Acidentes de Trânsito da Polícia Rodoviária Federal, correspondentes ao período de janeiro de 2008 a setembro de 2011. Os indicadores dos acidentes avaliados foram tipo, causa, período do dia, rodovia em que ocorreu e a faixa etária dos acidentados. Foi feito o uso de estatística não paramétrica, sendo os dados avaliados através de análise de frequência e teste de independência do qui-quadrado. A causa mais frequente foi a falta de atenção, o tipo com maior percentual foi a colisão traseira, o período do dia com o maior número de acidentes foi o da tarde, o maior percentual de acidentados encontra-se na faixa etária entre 40 a 44 anos e as rodovias com maior número de acidentes foi a BR-285 e BR116. Recomenda-se que o trator só entre na rodovia seguindo as normas de trânsito e de segurança, e que o operador faça pequenas pausas quando estiver trabalhando em longos períodos

  10. Value of three-dimensional computed tomography in screening cerebral aneurysms

    International Nuclear Information System (INIS)

    We performed three-dimensional computed tomography (3D-CT) in 6 patients of cerebral aneurysm. Prior cerebral angiography showed a total of 17 aneurysms. 3D-CT alone detected 10 cerebral aneurysm (59%). It was possible to identify aneurysms larger than 10 mm even when located near the circle of Willis. It was difficult to identify aneurysms when smaller than 7 mm regardless of their location. 3D-CT was of limited value in detecting cerebral aneurysms, particularly when located near the circle of Willis with complex vascular network. As cases of oculomotor palsy may be caused by lesions other than cerebral aneurysm, we advocate that 3D-CT be performed after magnetic resonance imaging (MRI) in screening cases of suspected cerebral aneurysm. (author)

  11. Value of three-dimensional computed tomography in screening cerebral aneurysms

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, Tamaki; Sugiura, Yusuke; Suzuki, Atsushi; Yamagata, Yoshitaka [Hyogo Medical Coll. (Japan)

    1997-10-01

    We performed three-dimensional computed tomography (3D-CT) in 6 patients of cerebral aneurysm. Prior cerebral angiography showed a total of 17 aneurysms. 3D-CT alone detected 10 cerebral aneurysm (59%). It was possible to identify aneurysms larger than 10 mm even when located near the circle of Willis. It was difficult to identify aneurysms when smaller than 7 mm regardless of their location. 3D-CT was of limited value in detecting cerebral aneurysms, particularly when located near the circle of Willis with complex vascular network. As cases of oculomotor palsy may be caused by lesions other than cerebral aneurysm, we advocate that 3D-CT be performed after magnetic resonance imaging (MRI) in screening cases of suspected cerebral aneurysm. (author)

  12. Multifocal vascular lesions.

    Science.gov (United States)

    Levin, Laura E; Lauren, Christine T

    2016-03-01

    Multifocal vascular lesions are important to recognize and appropriately diagnose. Generally first noticed on the skin, multifocal vascular lesions may have systemic involvement. Distinguishing among the different types of multifocal vascular lesions is often based on clinical features; however, radiological imaging and/or biopsy are frequently needed to identify distinct features and guide treatment. Knowledge of the systemic associations that can occur with different vascular anomalies may reduce life-threatening complications, such as coagulopathy, bleeding, cardiac compromise, and neurologic sequelae. This review provides a synopsis of the epidemiology, pathogenesis, presentation, workup, and treatment of several well-recognized multifocal vascular tumors and malformations. PMID:27607324

  13. 蒙特利尔认知量表在脑小血管病患者认知功能障碍筛查中的作用%Value of the Montreal cognitive assessment for the detection of vascular cognitive impairment in cerebral small vessel disease

    Institute of Scientific and Technical Information of China (English)

    孔凡斌; 杨芳; 陈卫; 赵仁亮

    2011-01-01

    目的 探讨蒙特利尔认知量表(MoCA)在脑小血管病(SVD)患者认知功能障碍评估中的意义.方法 将103 例SVD 患者分为认知功能正常组和认知功能障碍组,应用MoCA 量表及简易精神状态量表(MMSE)对所有患者进行认知功能评估.结果 (1)两组患者在年龄、性别、教育程度方面无统计学差异(P >0.05).(2)认知功能障碍组MoCA 总分为18.20 ±3.42,MMSE 总分为25.53 ±2.91,两结果之间具有相关性,Spearman 相关系数r =0.531(P <0.05).(3)两组之间相比较,除注意子项外,MoCA 量表其余子项目及总分均有统计学差异,而MMSE 量表只有总分、记忆子项及回忆子项有统计学差异.(4)应用最大约登指数确定MoCA 量表识别SVD 所致认知障碍的最佳截断值为22/23 分,此时MoCA 量表的敏感度和特异度分别为91.9%和95.1%.结论 MoCA 量表在SVD 患者认知功能障的筛查中具有较高的敏感性和特异性,其最佳截断值为22/23 分.%Objective Cognitive impairment that is caused by or associated with vascular factors has been termed " vascular cognitive impairment " , which comprises vascular dementia ( VD ) and vascular cognitive impairment no-dementia ( VCIND). VCIND is a term that broadly encompasses cognitive deficits associated with vascular disease which fall short of a dementia diagnosis . In this study we aimed to evaluate the validity of Montreal cognitive assessment in cognitive impairment caused by cerebral small vessel disease ( SVD). Methods According to the diagnostic criteria, 103 patients with SVD were divided into two groups , cognitive impairment group ( n = 62 ) and the control ( n = 41). All the patients were assessed with MoCA and MMSE. Results ( 1 ) No significant differences were found between the two groups on age , gender and education level (P >0. 05). (2)The total scores of MoCA and MMSE were 18. 20 ±3. 42,25. 53 ±2.91, respectively in the cognitive impairment group. There was high correlation

  14. Indian-ink perfusion based method for reconstructing continuous vascular networks in whole mouse brain.

    Directory of Open Access Journals (Sweden)

    Songchao Xue

    Full Text Available The topology of the cerebral vasculature, which is the energy transport corridor of the brain, can be used to study cerebral circulatory pathways. Limited by the restrictions of the vascular markers and imaging methods, studies on cerebral vascular structure now mainly focus on either observation of the macro vessels in a whole brain or imaging of the micro vessels in a small region. Simultaneous vascular studies of arteries, veins and capillaries have not been achieved in the whole brain of mammals. Here, we have combined the improved gelatin-Indian ink vessel perfusion process with Micro-Optical Sectioning Tomography for imaging the vessel network of an entire mouse brain. With 17 days of work, an integral dataset for the entire cerebral vessels was acquired. The voxel resolution is 0.35×0.4×2.0 µm(3 for the whole brain. Besides the observations of fine and complex vascular networks in the reconstructed slices and entire brain views, a representative continuous vascular tracking has been demonstrated in the deep thalamus. This study provided an effective method for studying the entire macro and micro vascular networks of mouse brain simultaneously.

  15. Angiografia vértebrobasilar retrógrada acidental. A propósito de dois casos

    Directory of Open Access Journals (Sweden)

    José Zaclis

    1955-12-01

    Full Text Available São apresentados dois casos de angiografia vértebro-basilar em pacientes submetidos a angiografia cerebral via carótida. Na discussão do mecanismo dessa eventualidade angiográfica é admitido o refluxo da substância radiopaca até a artéria subclávia de onde o contraste seria levado, pela corrente sangüínea, para o interior da artéria vertebral. Para que o contraste pudesse progredir em sentido contrário ao normal, é forçoso admitir a existência de uma oclusão da carótida acima do ponto em que ela fôra puncionada. Quanto à causa determinante do bloqueio vascular julgamos provável que se trate de uma válvula artificial resultante da laceração da íntima, como no caso de Sirois e col. Tendo a atenção despertada pelos casos relatados neste trabalho, pudemos obter, deliberadamente, angiografia do sistema vértebro-basilar injetando o contraste na carótida primitiva (punção percutânea e ocluindo êste vaso, mediante compressão digital acima do nível da punção. Para maior aproveitamento do contraste, um manguito insuflado, até o desaparecimento do pulso radial, é colocado no braço. Com êste artifício visamos impedir que parte do contraste seja levado, inutilmente, para os vasos do membro superior. Os pormenores do método e os resultados serão descritos em trabalho que será publicado oportunamente.

  16. Incidência de acidentes de trabalho relacionada com a não utilização das precauções universais

    Directory of Open Access Journals (Sweden)

    Marcia de Souza

    1993-12-01

    Full Text Available Entrevistados todos (57 os funcionários do serviço de enfermagem de um hospital geral governamental de São Paulo, que sofreram acidentes de trabalho relacionados a materiais pérfuro-cortantes, ou que tiveram contato com sangue ou fluidos corpóreos contaminados no período de janeiro a setembro de 1992. Desses, 15,8% (9 eram enfermeiras, 49,1% (28 auxiliares de enfermagem, 33,3% (19 atendentes de atendentes de enfermagem e 1,8% (1 escriturária, que apresentavam idade inferior a 40 anos. 66,1% possuiam 2º grau completo ou superior e entre 4 a 7 anos de experiência na função. Em relação ao turno de trabalho, 49,1% dos acidentes ocorreram pela manhã e 38,7% durante a noite, principalmente no Pronto Socorro (36,8%. Materiais pérfuro-cortantes foram responsáveis por 71 ,9% dos acidentes, sendo 75,0% entre os auxiliares de enfermagem. Os funcionários acidentados atribuiram a causa do acidente: a fatalidade, ao descuido ou imprudencia da equipe medica e ao reencape de agulhas. Quanto as consequencias, 57,0% dos acidentados por. respingo de secreção nos olhos desenvolveram conjuntivite e uma das funcionárias, Hepatite B. Este estudo mostrou que 78,1 % dos acidentes poderiam ter sido evitados, 57,0% apenas com o uso das Precauções Universais.

  17. Acidentes de transporte terrestre em cidade da Região Sul do Brasil: avaliação da cobertura e qualidade dos dados

    Directory of Open Access Journals (Sweden)

    Andrade Selma Maffei de

    2001-01-01

    Full Text Available O objetivo do estudo foi o de avaliar a cobertura policial e a validade dos dados registrados em fichas de pronto-socorro, internação e nas declarações de óbito de vítimas de acidentes de transporte terrestre ocorridos em Londrina, Paraná, Brasil. Foram estudadas 3.643 vítimas resultantes de acidentes ocorridos no primeiro semestre de 1996, para as quais observou-se um prazo de seguimento de 180 dias para verificar a ocorrência de óbito devido ao acidente. A cobertura policial desses acidentes foi bastante baixa (32,5% sendo maior para os ocupantes de carro (71,6% e menor para ciclistas (8,1% e pedestres (24,8%. A concordância entre as informações registradas originalmente e a obtida após investigação foi pequena nas declarações de óbito (coeficiente Kappa 0,10; IC 95%: 0,02-0,17 regular nas fichas de internação (coeficiente Kappa 0,33; IC 95%: 0,27-0,40 e substancial nas fichas de pronto-socorro (coeficiente Kappa 0,63; IC 95%: 0,61-0,65. Os resultados indicam que os registros policiais subestimam o número de vítimas por esses acidentes. Sugerem, ainda, ser necessário investir na melhoria da qualidade dessas informações, principalmente nos níveis de internação e óbito.

  18. Acidentes de transporte terrestre em cidade da Região Sul do Brasil: avaliação da cobertura e qualidade dos dados

    Directory of Open Access Journals (Sweden)

    Selma Maffei de Andrade

    2001-12-01

    Full Text Available O objetivo do estudo foi o de avaliar a cobertura policial e a validade dos dados registrados em fichas de pronto-socorro, internação e nas declarações de óbito de vítimas de acidentes de transporte terrestre ocorridos em Londrina, Paraná, Brasil. Foram estudadas 3.643 vítimas resultantes de acidentes ocorridos no primeiro semestre de 1996, para as quais observou-se um prazo de seguimento de 180 dias para verificar a ocorrência de óbito devido ao acidente. A cobertura policial desses acidentes foi bastante baixa (32,5% sendo maior para os ocupantes de carro (71,6% e menor para ciclistas (8,1% e pedestres (24,8%. A concordância entre as informações registradas originalmente e a obtida após investigação foi pequena nas declarações de óbito (coeficiente Kappa 0,10; IC 95%: 0,02-0,17 regular nas fichas de internação (coeficiente Kappa 0,33; IC 95%: 0,27-0,40 e substancial nas fichas de pronto-socorro (coeficiente Kappa 0,63; IC 95%: 0,61-0,65. Os resultados indicam que os registros policiais subestimam o número de vítimas por esses acidentes. Sugerem, ainda, ser necessário investir na melhoria da qualidade dessas informações, principalmente nos níveis de internação e óbito.

  19. Perfil epidemiológico de acidentes com material biológico entre estudantes de medicina em um pronto-socorro cirúrgico

    Directory of Open Access Journals (Sweden)

    Phillipe Geraldo Teixeira de Abreu Reis

    2013-08-01

    Full Text Available OBJETIVO: avaliar os acidentes com material biológico entre estudantes de medicina estagiando em um pronto-socorro de trauma e identificar as principais situações relacionadas, causas atribuídas e prevenção. MÉTODOS: estudo com abordagem quantitativa. Os dados foram coletados através de um questionário, aplicado via internet, contendo perguntas fechadas de escolha múltipla, referentes a acidentes com material biológico. A amostra obtida foi 100 estudantes. RESULTADOS: trinta e dois se acidentaram com materiais biológicos. As atividades de maior risco foram anestesia local (39,47%, sutura (18,42% e recapeamento de agulha (15,79%. As principais vias de exposição ao material biológico foram contato com olho ou mucosa, com 34%, através de seringa com agulha com 45%. Após a contaminação, apenas 52% notificaram o acidente ao setor responsável. CONCLUSÃO: as principais causas de acidente encontradas e vias de exposição podem ser atribuídas a diversos fatores, como falta de treinamento e ao não uso de equipamentos de proteção individual. Ações preventivas e educativas são de extrema importância para diminuir a incidência dos acidentes com materiais biológicos e melhorar a conduta pós-exposição. É preciso entender as principais causas atribuídas e situações relacionadas a fim de implantar medidas gerais e eficazes.

  20. 急性脑梗死患者血清 PD-ECGF和 VEGF 的动态变化%Dynamic changes of platelet derived endothelial cell growth factor and vascular endothelial growth factor in the serum of patients with acute cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    张晓玲; 钱淑霞; 官俏兵; 杜瑛媛; 翟丽萍; 王琰萍; 俞晓翔

    2013-01-01

    Objective To investigate the dynamic changes of platelet derived endothelial cel growth factor (PD-ECGF) and vascular endothelial growth factor (VEGF) in the serum of patients with acute cerebral infarction (ACI). Methods Thirty four patients with acute cerebral infarction and 30 healthy subjects (control group)were enrol ed in the study. The PD-ECGF and VEGF levels were detected by ELISA in patients on d1, d3, d7 and d14 after infarction as wel as in healthy controls. According to the size of lesions the patients were classified as large lesion group (n=10), middle lesion group (n=13) and smal lesion group (n=11); according to the etiology patients were classified as large-artery atherosclerosis group (LAA, n=15), smal -artery occlu-sion (SAO, n=10) group and cardioembolism (CE, n=9) group. Then the correlation between serum PD-ECGF,VEGF levels and infarct size, etiology were analyzed. Results Serum PD-ECGF and VEGF levels were significantly increased in patients with ACI at al time points compared with healthy controls (P<0.05). The levels of PD-ECGF in serum reached peak value after 3d, and VEGF reached peak value after 7d, and they remained high levels at d14 after stroke. PD-ECGF and VEGF showed dramatic in-crease in serum of large lesion group and LAA group (P<0.05). Conclusion The contents of serum PD-ECGF and VEGF in-crease dramatically in patients with acute cerebral infarction, and have correlation with infarct volume and etiology. The results in-dicate that PD-ECGF and VEGF may be involved in the pathophysiology of acute cerebral infarction.%  目的探讨急性脑梗死患者血清血小板衍生内皮细胞生长因子(PD-ECGF)和血管内皮细胞生长因子(VEGF)的动态变化并分析与梗死灶大小、梗死病因类型的相关性.方法采用双抗体夹心酶联免疫吸附法(ELISA)动态测定34例急性脑梗死患者在发病后第1、3、7、14天时血清 PD-ECGF 和 VEGF 的浓度,对照组为30例本院健康体检者.

  1. Impact of Endothelial Microparticles on Coagulation, Inflammation, and Angiogenesis in Age-Related Vascular Diseases

    Directory of Open Access Journals (Sweden)

    Margaret Markiewicz

    2013-01-01

    Full Text Available Endothelial microparticles (EMPs are complex vesicular structures that originate from plasma membranes of activated or apoptotic endothelial cells. EMPs play a significant role in vascular function by altering the processes of inflammation, coagulation, and angiogenesis, and they are key players in the pathogenesis of several vascular diseases. Circulating EMPs are increased in many age-related vascular diseases such as coronary artery disease, peripheral vascular disease, cerebral ischemia, and congestive heart failure. Their elevation in plasma has been considered as both a biomarker and bioactive effector of vascular damage and a target for vascular diseases. This review focuses on the pleiotropic roles of EMPs and the mechanisms that trigger their formation, particularly the involvement of decreased estrogen levels, thrombin, and PAI-1 as major factors that induce EMPs in age-related vascular diseases.

  2. Cerebrovascular endothelin receptor upregulation in cerebral ischemia

    DEFF Research Database (Denmark)

    Edvinsson, Lars

    2009-01-01

    Stroke is a serious neurological disease and the third leading cause of death in the western world. In roughly 15 % of the cases, the cause is due to an intracranial haemorrhage, and the remaining 85 % represent ischemic strokes. Ischemic stroke is caused by the occlusion of a cerebral artery...... either by an embolus or by local thrombosis. Several studies have shown an involvement of the endothelin system in ischemic stroke. This review aims to examine the alterations of vascular endothelin receptor expression in ischemic stroke. Furthermore, studies of the intracellular signalling pathways...... leading to the enhanced expression of vascular endothelin receptors show that both protein kinase C (PKC) and mitogen activating protein kinase (MAPK) play important roles. The results from this work provide new perspectives on the pathophysiology of ischemic stroke, and give a possible explanation...

  3. Comprehensive Overview of Contemporary Management Strategies for Cerebral Aneurysms.

    Science.gov (United States)

    Manhas, Amitoz; Nimjee, Shahid M; Agrawal, Abhishek; Zhang, Jonathan; Diaz, Orlando; Zomorodi, Ali R; Smith, Tony; Powers, Ciarán J; Sauvageau, Eric; Klucznik, Richard P; Ferrell, Andrew; Golshani, Kiarash; Stieg, Philip E; Britz, Gavin W

    2015-10-01

    Aneurysmal subarachnoid hemorrhage (SAH) remains an important health issue in the United States. Despite recent improvements in the diagnosis and treatment of cerebral aneurysms, the mortality rate following aneurysm rupture. In those patients who survive, up to 50% are left severely disabled. The goal of preventing the hemorrhage or re-hemorrhage can only be achieved by successfully excluding the aneurysm from the circulation. This article is a comprehensive review by contemporary vascular neurosurgeons and interventional neuroradiolgists on the modern management of cerebral aneurysms. PMID:26072457

  4. Comprehensive Overview of Contemporary Management Strategies for Cerebral Aneurysms.

    Science.gov (United States)

    Manhas, Amitoz; Nimjee, Shahid M; Agrawal, Abhishek; Zhang, Jonathan; Diaz, Orlando; Zomorodi, Ali R; Smith, Tony; Powers, Ciarán J; Sauvageau, Eric; Klucznik, Richard P; Ferrell, Andrew; Golshani, Kiarash; Stieg, Philip E; Britz, Gavin W

    2015-10-01

    Aneurysmal subarachnoid hemorrhage (SAH) remains an important health issue in the United States. Despite recent improvements in the diagnosis and treatment of cerebral aneurysms, the mortality rate following aneurysm rupture. In those patients who survive, up to 50% are left severely disabled. The goal of preventing the hemorrhage or re-hemorrhage can only be achieved by successfully excluding the aneurysm from the circulation. This article is a comprehensive review by contemporary vascular neurosurgeons and interventional neuroradiolgists on the modern management of cerebral aneurysms.

  5. Cerebral Palsy (CP) Quiz

    Science.gov (United States)

    ... Submit Button Past Emails CDC Features Pop Quiz: Cerebral Palsy Language: English Español (Spanish) Recommend on Facebook Tweet ... Sandy is the parent of a child with cerebral palsy and the Board President of Gio’s Garden , a ...

  6. Retinopathy in severe malaria in Ghanaian children - overlap between fundus changes in cerebral and non-cerebral malaria

    DEFF Research Database (Denmark)

    Essuman, Vera A; Ntim-Amponsah, Christine T; Astrup, Birgitte S;

    2010-01-01

    diagnostic tool. This study was designed to determine the diagnostic usefulness of retinopathy on ophthalmoscopy in severe malaria syndromes: Cerebral malaria (CM) and non-cerebral severe malaria (non-CM), i.e. malaria with respiratory distress (RD) and malaria with severe anaemia (SA), in Ghanaian children...... and engorged retinal veins, not previously described as a feature of CM, was the most common vascular abnormality(15/58 = 26%) and was detected even in the absence of papilloedema. CONCLUSION: Retinal whitening, a sign suggestive of retinal ischaemia, was significantly more common in CM than in non...

  7. The role of neurosonology in the diagnosis of vascular dementia.

    Science.gov (United States)

    Tsivgoulis, Georgios; Katsanos, Aristeidis H; Papageorgiou, Sokratis G; Dardiotis, Efthimios; Voumvourakis, Konstantinos; Giannopoulos, Sotirios

    2014-01-01

    Although transcranial sonography is not yet an established diagnostic modality for dementia screening or differential diagnosis of Alzheimer's disease (AD) from vascular dementia (VaD), intracranial hemodynamic assessment may provide crucial information about the association between cognitive deterioration and vascular risk factors. We conducted a systematic narrative review of available literature through MEDLINE and EMBASE search to identify all available data about the evaluation of VaD patients with transcranial Doppler, and to discuss further the vascular disorders of the cerebral circulation in patients with vascular cognitive impairment. According to the available literature data to date, VaD patients were found to have lower mean flow velocity values in four studies (indicating cerebral hypoperfusion), higher pulsatility indices in three studies (indicating increased downstream vascular resistance), and more severe impairment of cerebrovascular reactivity in five studies (indicating exhausted vasodilatory reserve) compared to AD patients and controls. Microembolic signals were also found to be significantly more common in patients with VaD or AD compared to their age- and gender-matched controls, suggesting that asymptomatic microembolism, apart for being only marker of VaD, could presumably be involved in the genesis of dementia, and in the overlap between VaD and AD. Further studies with larger and carefully selected groups are required to eliminate potential confounders and to set specific cut-off values for the aforementioned hemodynamic parameters in demented patients and dementia subtypes.

  8. Cerebral vascular complication and hyperhomocysteinemia in a cystinotic uremic child.

    Science.gov (United States)

    Merouani, A; Genest, J; Rozen, R; Lambert, M; Mitchell, G A; Dubois, J; Robitaille, P

    1999-01-01

    We report a 13-year-old girl with nephropathic cystinosis on chronic peritoneal dialysis who presented with two episodes of stroke. Laboratory evaluation showed severe hyperhomocysteinemia (108 mumol/l). Further testing revealed that she was homozygous for the thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR) gene. Treatment with folic acid and vitamin B12 lowered plasma homocysteine to less than 20 mumol/l. No further episodes of stroke occurred over a follow-up of 12 months. Homocysteine levels should be measured in patients with chronic renal failure, since simple and safe treatment with folic acid and vitamin B12 is effective in lowering the plasma homocysteine level in patients with the thermolabile MTHFR allele. PMID:10100295

  9. Li Yunjie, an Expert on Cardio-Cerebral Vascular Diseases

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    LiYunjie,anExpertonCardio-CerebralVascularDiseasesByWANGLIJUN&ZHIRENATTHEThirdConferenceonAcademicExchangesofLeadingInternati...

  10. Acute effects of tibolone on cerebral vascular reactivity in vitro

    DEFF Research Database (Denmark)

    Lund, C O; Nilas, Lisbeth; Dalsgaard, T;

    2003-01-01

    alpha-OH-tibolone, 3beta-OH-tibolone, Delta(4) isomer and 17beta-estradiol were obtained before and after addition of the NO blocker N(omega)-nitro-L-arginine methyl ester (L-NAME, 10(-4) mol/l) or the potassium-channel blocker tetraethylammonium chloride (TEA, 10(-2) mol/l). Additionally, the effects...... of the hormones on the concentration-response curves with calcium were examined. RESULTS: Tibolone and its metabolites induced a concentration-dependent relaxation comparable to that of 17beta-estradiol (area under the curve (AUC); tibolone vs. 17beta-estradiol: 242 vs. 251; p < 0.05, analysis of...... variance). L-NAME increased the AUC for all substances compared with controls (p < 0.05, Student's t test), except for 17beta-estradiol. Preincubation with TEA induced no changes. The concentration-dependent contraction curves with calcium were shifted rightward by all hormones. CONCLUSIONS: The study...

  11. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease.

    Science.gov (United States)

    Kalaria, Raj N

    2016-05-01

    Vascular dementia (VaD) is recognised as a neurocognitive disorder, which is explained by numerous vascular causes in the general absence of other pathologies. The heterogeneity of cerebrovascular disease makes it challenging to elucidate the neuropathological substrates and mechanisms of VaD as well as vascular cognitive impairment (VCI). Consensus and accurate diagnosis of VaD relies on wide-ranging clinical, neuropsychometric and neuroimaging measures with subsequent pathological confirmation. Pathological diagnosis of suspected clinical VaD requires adequate postmortem brain sampling and rigorous assessment methods to identify important substrates. Factors that define the subtypes of VaD include the nature and extent of vascular pathologies, degree of involvement of extra and intracranial vessels and the anatomical location of tissue changes. Atherosclerotic and cardioembolic diseases appear the most common substrates of vascular brain injury or infarction. Small vessel disease characterised by arteriolosclerosis and lacunar infarcts also causes cortical and subcortical microinfarcts, which appear to be the most robust substrates of cognitive impairment. Diffuse WM changes with loss of myelin and axonal abnormalities are common to almost all subtypes of VaD. Medial temporal lobe and hippocampal atrophy accompanied by variable hippocampal sclerosis are also features of VaD as they are of Alzheimer's disease. Recent observations suggest that there is a vascular basis for neuronal atrophy in both the temporal and frontal lobes in VaD that is entirely independent of any Alzheimer pathology. Further knowledge on specific neuronal and dendro-synaptic changes in key regions resulting in executive dysfunction and other cognitive deficits, which define VCI and VaD, needs to be gathered. Hereditary arteriopathies such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy or CADASIL have provided insights into the mechanisms of

  12. Vascularity in thyroid neoplasms

    DEFF Research Database (Denmark)

    Larsen, Karen Kjaer; Andersen, Niels Frost; Melsen, Flemming;

    2006-01-01

    The aim of the present study was to evaluate the reliability of four different methods (vascular grading, Chalkley count, microvessel density (MVD) and stereological estimation) for quantifying intratumoral microvascularity in thyroid neoplasms, by comparing the variability within and between...... count should be the preferred method for assessing microvascularity in thyroid neoplasms. The diagnostic evaluation revealed a tendency towards higher degree of vascularity in FA compared to both FC and PC for all methods. No statistically significant association was seen between vascular density and...

  13. Vascular cognitive impairment

    OpenAIRE

    Rebecca F. Gottesman; Hillis, Argye E.

    2014-01-01

    The term vascular cognitive impairment (VCI) has been proposed to encompass all people with cognitive impairment of cerebrovascular origin. VCI is not a single condition, but has several clinical presentations, etiologies, and treatment. VCI forms a spectrum that includes vascular dementia, mixed Alzheimer’s disease with a vascular component, and VCI that does not meet dementia criteria. Multiple pathophysiological mechanisms contribute to VCI, accounting for its heterogeneity. Although main ...

  14. Impacto psicológico dos acidentes rodoviários nas sua vítimas directas

    OpenAIRE

    Pires, Tânia Sofia Fernandes

    2011-01-01

    Tese doutoramento em Psicologia (área de especialização em Psicologia da Saúde) Portugal encontra-se entre os países da Europa em que a sinistralidade rodoviária é das mais elevadas. Para além de ser um tema actual para os cidadãos, os acidentes são uma das preocupações da saúde pública (OMS, 2009), sendo também considerados acontecimentos traumáticos (APA, 2002), que podem dar origem a perturbação psicológica, designadamente Perturbação Aguda de Stress (PAS) e Perturbação de ...

  15. Vascular hemichorea: case report and review

    Directory of Open Access Journals (Sweden)

    Bárbara Martínez Alfonzo

    2014-04-01

    Full Text Available Chorea rarely complicates ischemic or hemorrhagic cerebral vascular lesions. Clinical symptoms usually involve one side of the body while the injury is situated on the contralateral cerebral hemisphere. Spontaneous remission is the norm, but sometimes symptomatic treatment is required. A 58-year-old male patient who suffers from untreated high blood pressure, type II obesity, smokes 6 packs of cigarettes per year and has a moderate intake of alcohol is presented. The patient’s recent history began three days before he appeared at the Emergency Department. His symptoms were ceaseless, involuntary movements in his left arm and foot during day and night with no restriction of voluntary movements. Physical examination and laboratory tests revealed no other findings. Magnetic resonance imaging of the brain showed hyperintensity in the right posterolateral thalamic region consistent with ischemic cerebrovascular disease. Symptomatic therapy was indicated and his underlying conditions were addressed. The importance of this case lies on the low prevalence as well as the scarcity of publications regarding vascular causes of hemichorea, including diagnosis, therapy and prognosis.

  16. Investigation and analysis of mental health status of hospitalized patients with cerebral vascular disease in neurology department of a hospital%某三甲医院脑血管疾病住院患者心理健康状况的调查分析

    Institute of Scientific and Technical Information of China (English)

    倪健; 张秀军; 高国朋; 李修德; 李享; 王程成; 仝菲

    2014-01-01

    Objective To explore the mental health status of patients with cerebral vascular disease in neurology department of the Peo-ple’s hospital of Lu’an City in Anhui,and to investigate the related factors of emotional disorders.Methods Nearly 300 hospitalizedpatients(127 males,173 females,aged 22 ~81 yrs)with cerebral vascular disease at the neurology department of the hospital in thepast 2 years were selected as the study group,while 300 healthy people(142 males,158 females,aged 21 ~77 yrs)at the outpatientmedical examinations as the control group.To analysis the influence factors of emotional disorder,Hamilton anxiety and depression self-rating depression scale,social support scale were all taken for scoring records and statistics.Results Results of HAMD,HAMA scoreshowed,168 cases had been checked out symptoms of emotional disorders (56%)in the study group,there into the incidence of de-pressive symptoms patients was 76.79%,and the incidence of anxiety symptoms patients was 62.50%,were both higher than the con-trol group,and the difference had a statistically significant (P <0.001).Combined results of MESS assessment,the incidence of emo-tional disorders in severe neurological deficits patients for 87.34%,incidence in medium neurological deficits patients for 55.24%,were both significantly higher than the light neurologic deficits patients (35.34%),the difference was statistically significant (P <0.05).Results of PSSS assessment showed that social support score of study group (68.02 ±9.34),which were lower than that of thecontrol group(88.36 ±7.54),the differences were statistical significantly (t =29.35,P <0.001).Linear correlation analysis had beentaken between3 dimensions of the Neurologic rating and HAMD,HAMA standard,turned out that there was a positive correlation be-tween them,the difference was statistically significant (P <0.05).Conclusion The mental problems of hospitalized patients with ce-rebrovascular disease in neurology department are mainly

  17. Alterações parenquimatosas na trombose venosa cerebral: aspectos da ressonância magnética e da angiorressonância Parenchymal abnormalities in cerebral venous thrombosis: findings of magnetic resonance imaging and magnetic resonance angiography

    Directory of Open Access Journals (Sweden)

    Clécia Santos Ferreira

    2006-10-01

    Full Text Available OBJETIVO: Determinar a freqüência e localização das alterações parenquimatosas da trombose venosa cerebral nos exames de ressonância magnética e de angiorressonância, bem como a correlação com o território e a drenagem venosa comprometida. MATERIAIS E MÉTODOS: Foram analisados exames de 21 pacientes realizados entre 1996 e 2004, com diagnóstico clínico e radiológico de trombose venosa cerebral em exames de ressonância magnética e de angiorressonância nas seqüências 2D PC, 3D PC e 3D TOF com contraste paramagnético. Análise estatística foi realizada com o teste do qui quadrado. Quatro pacientes tinham exames de controle e três realizaram angiografia por subtração digital. RESULTADOS: Dos 21 pacientes, 18 eram mulheres, todos com idade entre três e 82 anos (média de 40 anos e mediana de 36 anos. Os principais fatores etiológicos foram infecção, uso de contraceptivos orais, reposição hormonal e colagenoses. Predominaram os sintomas de déficit focal, cefaléia, alteração do nível de consciência e convulsões. Por freqüência, as manifestações parenquimatosas foram: edema/infarto de distribuição cortical e/ou subcortical, congestão venosa e circulação colateral, realce meníngeo e infarto ou edema dos tálamos e núcleos da base. Os principais seios comprometidos foram o sagital superior, o transverso esquerdo, o sigmóide esquerdo e o seio reto, sendo incomum o acometimento dos seios cavernosos e de veias corticais. CONCLUSÃO: A trombose venosa cerebral é causa incomum de acidente vascular encefálico, com prognóstico favorável pelo caráter reversível das lesões. Seu diagnóstico depende fundamentalmente da capacidade do radiologista reconhecer suas formas de apresentação, principalmente nos casos em que ele é sugerido pelas alterações parenquimatosas e não necessariamente pela visualização do trombo. A precisão e a rapidez no diagnóstico permitem o pronto tratamento, reduzindo a morbi

  18. Early exercise improves cerebral blood flow through increased angiogenesis in experimental stroke rat model

    OpenAIRE

    Zhang, Pengyue; Yu, Huixian; Zhou, Naiyun; Jie ZHANG; Wu, Yi; Zhang, Yuling; Bai, Yulong; Jia, Jie; Zhang, Qi; Tian, Shan; Wu, Junfa; Hu, Yongshan

    2013-01-01

    Background Early exercise after stroke promoted angiogenesis and increased microvessles density. However, whether these newly formatted vessels indeed give rise to functional vascular and improve the cerebral blood flow (CBF) in impaired brain region is still unclear. The present study aimed to determine the effect of early exercise on angiogenesis and CBF in ischemic region. Methods Adult male Sprague Dawley rats were subjected to 90 min middle cerebral artery occlusion(MCAO)and randomly div...

  19. A case of postvaricella cerebral angiopathy with a good outcome in a child

    OpenAIRE

    Maria Cristina Magagnini; Luisa La Spina; Daniela Gioé; G Del Campo; G Belfiore; Smilari, P.; Filippo Greco

    2015-01-01

    Cerebral vasculopathy is a serious but uncommon complication of varicella-zoster-virus (VZV) infection. Diagnosis is based on a recent history of VZV infection, signs and symptoms of transient ischemic attack or stroke, and vascular anomalies on neuroimaging. We report a case of postvaricella cerebral angiopathy in a 5-year-old child, who was admitted after three episodes of transient right hemiplegia, each one lasting a few minutes. He had contracted chicken pox, the month prior to admission...

  20. Neuroprotective effect of penehyclidine hydrochloride on focal cerebral ischemiareperfusion injury

    Institute of Scientific and Technical Information of China (English)

    Cuicui Yu; Junke Wang

    2013-01-01

    Penehyclidine hydrochloride can promote microcirculation and reduce vascular permeability. However, the role of penehyclidine hydrochloride in cerebral ischemia-reperfusion injury remains unclear. In this study, in vivo middle cerebral artery occlusion models were established in experimental rats, and penehyclidine hydrochloride pretreatment was given via intravenous injection prior to model establishment. Tetrazolium chloride, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling and immunohistochemical staining showed that, penehyclidine hydrochloride pretreatment markedly attenuated neuronal histopathological changes in the cortex, hippocampus and striatum, reduced infarction size, increased the expression level of Bcl-2, decreased the expression level of caspase-3, and inhibited neuronal apoptosis in rats with cerebral ischemia-reperfusion injury. Xanthine oxidase and thiobarbituric acid chromogenic results showed that penehyclidine hydrochloride upregulated the activity of superoxide dismutase and downregulated the concentration of malondialdehyde in the ischemic cerebral cortex and hippocampus, as well as reduced the concentration of extracellular excitatory amino acids in rats with cerebral ischemia-reperfusion injury. In addition, penehyclidine hydrochloride inhibited the expression level of the NR1 subunit in hippocampal nerve cells in vitro following oxygen-glucose deprivation, as detected by PCR. Experimental findings indicate that penehyclidine hydrochloride attenuates neuronal apoptosis and oxidative stress injury after focal cerebral ischemia-reperfusion, thus exerting a neuroprotective effect.

  1. Neuroprotective effects of rutaecarpine on cerebral ischemia reperfusion injury**

    Institute of Scientific and Technical Information of China (English)

    Chunlin Yan; Ji Zhang; Shu Wang; Guiping Xue; Yong Hou

    2013-01-01

    Rutaecarpine, an active component of the traditional Chinese medicine Tetradium ruticarpum, has been shown to improve myocardial ischemia reperfusion injury. Because both cardiovascular and cerebrovascular diseases are forms of ischemic vascular disease, they are closely related. We hypothesized that rutaecarpine also has neuroprotective effects on cerebral ischemia reperfusion injury. A cerebral ischemia reperfusion model was established after 84, 252 and 504 µg/kg carpine were given to mice via intraperitoneal injection, daily for 7 days. Results of the step through test, 2,3,5-triphenyl tetrazolium chloride dyeing and oxidative stress indicators showed that rutae-carpine could improve learning and memory ability, neurological symptoms and reduce infarction volume and cerebral water content in mice with cerebral ischemia reperfusion injury. Rutaecarpine could significantly decrease the malondialdehyde content and increase the activities of superoxide dismutase and glutathione peroxidase in mouse brain. Therefore, rutaecarpine could improve neu-rological function fol owing injury induced by cerebral ischemia reperfusion, and the mechanism of this improvement may be associated with oxidative stress. These results verify that rutaecarpine has neuroprotective effects on cerebral ischemia reperfusion in mice.

  2. Unilateral cerebral polymicrogyria with ipsilateral cerebral hemiatrophy

    International Nuclear Information System (INIS)

    We evaluated six children in whom MR imaging showed unilateral cerebral polymicrogyria associated with ipsilateral cerebral atrophy and ipsilateral brain stem atrophy. The aim of this study was to clarify whether this disorder based on neuroimaging constitutes a new homogeneous clinical entity. The subjects were six children whose ages at the time of MR imaging ranged from 8 months to 11 years. Their clinical and MR features were analyzed. All of the children were born between 38 and 42 weeks gestation, without any significant perinatal events. Spastic hemiplegia and epilepsy were observed in all of the patients, and mental retardation was observed in four. The MR findings included unilateral cerebral polymicrogyria associated with ipsilateral cerebral hemiatrophy and ipsilateral brain stem atrophy in all patients. The ipsilateral sylvian fissure was hypoplastic in four patients. These patients showed relatively homogeneous clinical and neuroimaging features. Although the additional clinical features varied according to the site and the extent affected by the polymicrogyria, this disorder could constitute a new relatively homogeneous clinical entity. (orig.)

  3. Unilateral cerebral polymicrogyria with ipsilateral cerebral hemiatrophy

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, Katsumi [Department of Radiology, Kyoto City Hospital, 1-2 Higashi-Takada-cho, Mibu, Nakagyo-ku, 604-8845 Kyoto (Japan); Kanda, Toyoko; Yamori, Yuriko [Department of Pediatric Neurology, St. Joseph Hospital for Handicapped Children, 603-8323 Kyoto (Japan)

    2002-10-01

    We evaluated six children in whom MR imaging showed unilateral cerebral polymicrogyria associated with ipsilateral cerebral atrophy and ipsilateral brain stem atrophy. The aim of this study was to clarify whether this disorder based on neuroimaging constitutes a new homogeneous clinical entity. The subjects were six children whose ages at the time of MR imaging ranged from 8 months to 11 years. Their clinical and MR features were analyzed. All of the children were born between 38 and 42 weeks gestation, without any significant perinatal events. Spastic hemiplegia and epilepsy were observed in all of the patients, and mental retardation was observed in four. The MR findings included unilateral cerebral polymicrogyria associated with ipsilateral cerebral hemiatrophy and ipsilateral brain stem atrophy in all patients. The ipsilateral sylvian fissure was hypoplastic in four patients. These patients showed relatively homogeneous clinical and neuroimaging features. Although the additional clinical features varied according to the site and the extent affected by the polymicrogyria, this disorder could constitute a new relatively homogeneous clinical entity. (orig.)

  4. Risk of Cerebral Palsy among the Offspring of Immigrants

    OpenAIRE

    Ray, Joel G; Donald A Redelmeier; Marcelo L Urquia; Astrid Guttmann; McDonald, Sarah D; Vermeulen, Marian J.

    2014-01-01

    Background Cerebral palsy (CP) has a multifactorial etiology, and placental vascular disease may be one major risk factor. The risk of placental vascular disease may be lower among some immigrant groups. We studied the association between immigrant status and the risk of CP. Methods We conducted a population-based retrospective cohort study of all singleton and twin livebirths in Ontario between 2002–2008, and who survived ≥28 days after birth. Each child was assessed for CP up to age 4 years...

  5. Cerebral Small Vessel Disease and Risk of Death, Ischemic Stroke, and Cardiac Complications in Patients With Atherosclerotic Disease The Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) Study

    NARCIS (Netherlands)

    M.M.A. Conijn; R.P. Kloppenborg; A. Algra; W.P.T.M. Mali; L.J. Kappelle; K.L. Vincken; Y. van der Graaf; M.I. Geerlings

    2011-01-01

    Background and Purpose-Cerebral small vessel disease may be related to vascular and nonvascular pathology. We assessed whether lacunar infarcts and white matter lesions on MRI increased the risk of vascular and nonvascular death and future vascular events in patients with atherosclerotic disease. Me

  6. Cerebral Lesions in Patients Undergoing Coronary Artery Bypass Grafting in Relation to Asymptomatic Carotid and Vertebral Artery Stenosis

    DEFF Research Database (Denmark)

    Wiberg, Sebastian; Schoos, Mikkel; Sillesen, Henrik;

    2015-01-01

    OBJECTIVES: Carotid artery stenosis (CAS) and vertebral artery stenosis (VAS) are associated with cerebral infarction after coronary artery bypass graft surgery (CABG). It remains unclear whether this association is causal. We investigated the associations between neurologically asymptomatic CAS...... association between the presence of cerebral vessel stenosis and acute cerebral infarction (67% vs. 27%, p = 0.047). However none of the patients with stenosis had isolated cerebral lesions in the ipsilateral vascular territory. CONCLUSION: Asymptomatic CAS and VAS is common in CABG patients and is associated...

  7. Cerebral arterial spasm. II. Etiology and treatment of experimental cerebral vasospasm.

    Directory of Open Access Journals (Sweden)

    Morooka,Hiroshi

    1978-04-01

    Full Text Available Delayed cerebral vasospams is caused by excessive accumulation of dopamine-beta-hydroxylase (DBH and noradrenaline in cerebral vessel walls. This study demonstrates the mechanisms of delayed spasm, particularly the role of red blood cell components, and the successful relief of delayed cerebral vasospasm. Spasmogenic substances which contained a heme component, such as methemoglobin, methemalbumin and catalase enhanced DBH activity in human serum as measured by a one step chemical spectrophotometric assay. The concentration which gave the highest DBH activity caused the maximum constriction of the basilar artery, when the substances were applied topically. Among components of red cells, methemoglobin, methemalbumin, catalase and nicotinamid adenin dinucleotide (NADH caused constriction of basilar artery in cats, when applied topically, whereas hematin, hemin and bilirubin caused no significant spasm. An oxyhemoglobin solution obtained by mixture with methemoglobin and ascorbic acid produced no significant vascular spasm either. Relief of delayed cerebral vasospasm was obtained with topical application of specific alpha adrenergic blocking drug such as phenoxybenzamine, specific inhibitors of DBH such as fusaric acid, o-phenanthroline and alphaalpha' dipyridyl beta2 adrenergic stimulants such as salbutamol, and a phosphodiesterase inhibitor, ascorbic acid.

  8. Risk factors for vascular dementia: Hypotension as a key point

    Directory of Open Access Journals (Sweden)

    Rita Moretti

    2008-04-01

    Full Text Available Rita Moretti, Paola Torre, Rodolfo M Antonello, Davide Manganaro, Cristina Vilotti, Gilberto PizzolatoDepartment of Internal Medicine and Clinical Neurology University of Trieste, ItalyAbstract: Physiologically, the cerebral autoregulation system allows maintenance of constant cerebral blood flow over a wide range of blood pressure. In old people, there is a progressive reshape of cerebral autoregulation from a sigmoid curve to a straight line. This implies that any abrupt change in blood pressure will result in a rapid and significant change in cerebral blood flow. Hypertension has often been observed to be a risk factor for vascular dementia (VaD and sometimes for Alzheimer disease although not always. Indeed, high blood pressure may accelerate cerebral white matter lesions, but white matter lesions have been found to be facilitated by excessive fall in blood pressure, including orthostatic dysregulation and postprandial hypotension. Many recent studies observed among other data, that there was a correlation between systolic pressure reduction and cognitive decline in women, which was not accounted for by other factors. Baseline blood pressure level was not significantly related to cognitive decline with initial good cognition. Some researchers speculate that blood pressure reduction might be an early change of the dementing process. The most confounding factor is that low pressure by itself might be a predictor of death; nevertheless, the effect of low blood pressure on cognition is underestimated because of a survival bias. Another explanation is that clinically unrecognized vascular lesions in the brain or atherosclerosis are responsible for both cognitive decline and blood pressure reduction. We discuss the entire process, and try to define a possible mechanism that is able to explain the dynamic by which hypotension might be related to dementia.Keywords: vascular dementia, hypotension, low blood pressure, alzheimer disease

  9. Local vascular CO2 reactivity in the infant brain assessed by functional MRI

    DEFF Research Database (Denmark)

    Toft, P.B.; Leth, H; Lou, H.C.;

    1995-01-01

    hyperventilated voluntarily, the vascular reactivity was homogeneously distributed predominantly over the grey matter. The experiments demonstrate that local impairment of vascular CO2 reactivity in the distressed infant brain can be detected by T2 sensitive gradient-echo MRI, which is also known as functional......The local cerebral vascular response to hyperventilation was investigated in five distressed, intubated infants by means of a T2 sensitive gradient-echo MRI technique at 1.5 T. In one preterm infant, the MR signal change during hyperventilation was sparse. In four term infants, the mean MR signal...... of the brain slice investigated decreased by 1.2-2.6% per kPa change in PCO2 as a reflection of decreased cerebral blood flow during hyperventilation. Pixel-wise analysis revealed absence of vascular response in the basal ganglia, the thalamus or in the occipital region. In two adult controls, who...

  10. Local vascular CO2 reactivity in the infant brain assessed by functional MRI

    International Nuclear Information System (INIS)

    The local cerebral vascular response to hyperventilation was investigated in five distressed, intubated infants by means of a T2' sensitive gradient-echo MRI technique at 1.5 T. In one preterm infant, the MR signal change during hyperventilation was sparse. In four term infants, the mean MR signal of the brain slice investigated decreased by 1.2-2.6% per kPa change in PCO2 as a reflection of decreased cerebral blood flow during hyperventilation. Pixel-wise analysis revealed absence of vascular response in the basal ganglia, the thalamus or in the occipital region. In two adult controls, who hyperventilated voluntarily, the vascular reactivity was homogeneously distributed predominantly over the grey matter. The experiments demonstrate that local impairment of vascular CO2 reactivity in the distressed infant brain can be detected by T2' sensitive gradient-echo MRI, which is also known as functional MRI. (orig.)

  11. Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats.

    Science.gov (United States)

    Cao, Xiao-Lu; Du, Jing; Zhang, Ying; Yan, Jing-Ting; Hu, Xia-Min

    2015-10-01

    Recent studies showed that hyperglycemia enhanced brain damage when subjected to transient cerebral ischemic stroke. However, the etiologic link between them has been less known. In the present study, based on an experimental rat's model of hyperlipidemia combined with cerebral ischemia-reperfusion injury (I/R), we herein showed that hyperlipidemia induced by high-fat diet (HFD) resulted in considerable increase in serum triglycerides, cholesterol and low-density lipoprotein cholesterol, and remarkable decrease in serum high-density lipoprotein cholesterol, which associated with an exacerbation on neurological deficit, cerebral infarct and terminal deoxynucleotidyl transferase-mediated nick end labeling-positive cells in the ischemic hemisphere of cerebral I/R rats treated with HFD diet. The data showed that serum superoxide dismutase activity and glutathione peroxides content were significantly decreased, while malondialdehyde level was obviously increased by hyperlipidemia or cerebral I/R alone, especially by coexistence of hyperlipidemia and cerebral I/R; meantime, hyperlipidemia also enhanced cerebral I/R-induced protein expression of cytochrome P450 2E1 (CYP2E1) and the levels of pro-inflammatory factors tumor necrosis factor-α and IL-6 in the ischemic hemispheres. Furthermore, the combined action of hyperlipidemia and cerebral I/R resulted in a protein increase expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 compared to hyperlipidemia or cerebral I/R alone. Meanwhile, this study also showed that hyperlipidemia significantly enhanced cerebral I/R-induced transfer of cytochrome c from mitochondria to cytosolic and the protein expressions of Apaf-1 and caspase-3, but also decreased cerebral I/R-induced bcl-2 protein expression. The results reveal that hyperlipidemia exacerbates cerebral I/R-induced injury through the synergistic effect on CYP2E1 induction, which further induces reactive oxygen species formation, oxidative

  12. [CT findings in "fresh" cerebral paragonimiasis].

    Science.gov (United States)

    Li, H Z; Xie, F W; Sun, S C

    1992-01-01

    There are few reports on CT findings in "fresh" cerebral paragonimiasis. We have experienced four cases of "fresh" cerebral paragonimiasis examined by CT scan. Three patients were children aged 7, 9, and 14 years, and one was an adult aged 25 years. Three patients were examined by CT scan 2 to 6 months after the onset of high grade fever, convulsion and focal deficit signs, and a patient was examined one month after his progressive visual disturbance. The unique CT findings are multilocular cystic lesions in temporo-occipital or in temporo-parietal lobes with extensive brain edema. Two cases were also associated with "soap-bubble" calcifications. The cysts were more dense than CSF and enhanced by contrast media. The histopathological specimen showed that the eggs of paragonimus were in the abscess cavity, of which the wall was composed with highly vascular gliomesenchymal capsule and numerous cell infiltration. Three patients underwent craniotomy for removal of abscess and decompression. Bitionol were administered and all patients recovered well. We also discussed the differential diagnosis of cerebral parasitic granulomas.

  13. Complications of endovascular treatment of cerebral aneurysms

    Energy Technology Data Exchange (ETDEWEB)

    Orrù, Emanuele, E-mail: surgeon.ema@gmail.com [Neuroradiology Department, Padua University Hospital, Via Giustiniani 2, Padua 35128 (Italy); Roccatagliata, Luca, E-mail: lroccatagliata@neurologia.unige.it [Neuroradiology Department, IRCCS San Martino University Hospital and IST, Largo Rosanna Benzi 10, Genoa 16132 (Italy); Department of Health Sciences (DISSAL), University of Genoa (Italy); Cester, Giacomo, E-mail: giacomo.cester@sanita.padova.it [Neuroradiology Department, Padua University Hospital, Via Giustiniani 2, Padua 35128 (Italy); Causin, Francesco, E-mail: francesco.causin@sanita.padova.it [Neuroradiology Department, Padua University Hospital, Via Giustiniani 2, Padua 35128 (Italy); Castellan, Lucio, E-mail: lucio.castellan@hsanmartino.it [Neuroradiology Department, IRCCS San Martino University Hospital and IST, Largo Rosanna Benzi 10, Genoa 16132 (Italy)

    2013-10-01

    The number of neuroendovascular treatments of both ruptured and unruptured aneurysms has increased substantially in the last two decades. Complications of endovascular treatments of cerebral aneurysms are rare but can potentially lead to acute worsening of the neurological status, to new neurological deficits or death. Some of the possible complications, such as vascular access site complications or systemic side effects associated with contrast medium (e.g. contrast medium allergy, contrast induced nephropathy) can also be encountered in diagnostic angiography. The most common complications of endovascular treatment of cerebral aneurysms are related to acute thromboembolic events and perforation of the aneurysm. Overall, the reported rate of thromboembolic complications ranges between 4.7% and 12.5% while the rate of intraprocedural rupture of cerebral aneurysms is about 0.7% in patients with unruptured aneurysms and about 4.1% in patients with previously ruptured aneurysms. Thromboembolic and hemorrhagic complications may occur during different phases of endovascular procedures and are related to different technical, clinical and anatomic reasons. A thorough knowledge of the different aspects of these complications can reduce the risk of their occurrence and minimize their clinical sequelae. A deep understanding of complications and of their management is thus part of the best standard of care.

  14. Cerebral Microbleeds: Detection, Associations and Clinical Implications.

    Science.gov (United States)

    Yakushiji, Yusuke

    2015-01-01

    Vigorous investigations for cerebral microbleeds (CMBs) have been made since the late 1990s. CMBs on paramagnetic-sensitive magnetic resonance sequences correspond pathologically to clusters of hemosiderin-laden macrophages and have emerged as an important new imaging marker of cerebral small vessel disease, including intracerebral hemorrhage (ICH). The prevalence of CMBs varies according to the specific disease settings (stroke subtypes and dementing disorders) and is highest (60%) in ICH patients. The associations of CMBs with aging, hypertension and apolipoprotein E genotype are consistent with the two major underlying pathogeneses of CMBs: hypertensive arteriopathy and cerebral amyloid angiopathy (CAA). The distributional patterns of CMBs might help us to understand the predominant small vessel disease pathogenesis in the brain; the strictly lobar type of CMBs often reflects the presence of advanced CAA, while the other types of CMBs, such as 'deep or infratentorial CMBs', including the mixed type, are strongly associated with hypertension. CMBs might be associated with cognitive function (especially executive function), gait performance, and cerebrovascular events (spontaneous, antithrombotic drug-related or post-thrombolysis ICH). In the field of CAA, an understanding of CAA-related CMBs might help to guide decision making with regard to new therapeutic approaches, including the use of monoclonal antibodies against vascular amyloid. These concepts of CMBs might allow us to advance research on ICH as well as for dementia. PMID:26587900

  15. Endovascular Therapy Followed by Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations

    OpenAIRE

    Arai, Y.; Handa, Y.; Ishii, H; Ueda, Y.; Uno, H; Nakajima, T.; Hirose, S; Kubota, T.

    2006-01-01

    Pre-radiosurgical embolization was carried out using cyanoacrylate in seven of 13 patients with cerebral arteriovenous malformations (AVMs) treated by stereotactic radiosurgery (SRS) with a linear accelerator (LINAC). The aim of embolization before SRS was the reduction of AVM volume and/or the elimination of vascular structures bearing an increased risk of haemorrhage. Staged-volume SRS was also performed in two patients because of residual irregular shaped nidus of AVMs even after the embol...

  16. Doppler velocimetry with emphasis on the fetal cerebral circulation

    OpenAIRE

    Noordam, Marja

    1996-01-01

    textabstractIn this thesis the following questions were addressed: 1. Are changes in placental vascular resistance associated with alterations in arterial down stream impedance at fetal level? To this purpose placental embolization was carried-out in the fetal lamb with subsequent Doppler velocimetry in the fetal descending aorta (chapter 2). 2. What happens to the human fetal cerebral circulation relative to normal and raised umbilical placental resistance? To answer this question, the human...

  17. [Vascular graft prosthesis].

    Science.gov (United States)

    Chakfé, N; Dieval, F; Thaveau, F; Rinckenbach, S; Hassani, O; Camelot, G; Durand, B; Kretz, J-G

    2004-06-01

    Performed since the 1950s, vascular grafting has opened modern era of vascular surgery. Autologous venous grafts are of first choice for revascularisation of small arteries. Synthetic grafts are mainly modelled using microporous polytetrafluoroethylene or terephtalate polyethylene. These prosthesis are mainly used for revascularization of medium and large size arteries. PMID:15220107

  18. Cerebral Aneurysms Fact Sheet

    Science.gov (United States)

    ... cerebral aneurysm from forming. People with a diagnosed brain aneurysm should carefully control high blood pressure, stop smoking, and avoid cocaine use or other stimulant drugs. They should also ...

  19. Cerebral amyloid angiopathy

    Science.gov (United States)

    ... Fenichel GM, Jankovic J, Mazziotta JC, eds. Bradley's Neurology in Clinical Practice . 6th ed. Philadelphia, PA: Elsevier ... al. Course of cerebral amyloid angiopathy-related inflammation. Neurology. 2007;68:1411-1416. PMID: 17452586 www.ncbi. ...

  20. Cerebral venous sinus thrombosis as presenting feature of ulcerative colitis.

    Science.gov (United States)

    Ennaifer, R; Moussa, A; Mouelhi, L; Salem, M; Bouzaidi, S; Debbeche, R; Trabelsi, S; Najjar, T

    2009-01-01

    Thrombosis is a well recognized complication of inflammatory bowel disease that occurs in 1.3 to 6.4% of patients, however, cerebral vascular involvement is unusual. We present the case of a 16-year-old female in whom cerebral venous thrombosis was the presenting symptom of an active ulcerative pancolitis. Thrombophilia screen (plasma levels of proteins C and S, antithrombin, antibeta2-glycoprotein, lupus anticoagulant and anticardiolipin antibodies, activated protein C resistance, homocystein level antinuclear antibodies) was negative. The patient was successfully treated with anticoagulant therapy, phenobarbital and sulfasalazine. Cerebral venous thrombosis is an exceptional presenting feature of ulcerative colitis. Disease activity may play a major role in the occurrence of thrombosis. PMID:19902870

  1. CEREBRAL INFARCTION IN A YOUNG FEMALE FOLLOWING SNAKE BITE

    Directory of Open Access Journals (Sweden)

    Rajesh Reddy Venkata Komatla

    2016-06-01

    Full Text Available Cerebral complications, particularly ischaemic infarcts after snake bites are rare. Multiple mechanisms are involved in cerebral infarction following snake envenomation. Possible mechanisms include: (1 Anticoagulant and procoagulant effects of snake venom leading to microthrombi, (2 Direct cardiotoxic effects of venom causing dysrhythmias, leading to cardiac thromboembolism and (3 Severe vascular spasm, hypotension and hyperviscosity caused by hypovolaemia. We report a case of a 35-year-old female patient who presented to our casualty with history of snake bite. Following which, she developed bleeding from puncture site with deranged PT INR and anti-snake venom was given. The following day, patient developed right-sided monoplegia with Broca’s aphasia and repeat PT INR came back normal. Imaging showed an ischaemic infarct in left middle cerebral artery territory. Patient was treated accordingly and discharged with residual deficit after a week. Patient is under followup and doing well.

  2. Acute ischemic cerebral attack

    OpenAIRE

    Franco-Garcia Samir; Barreiro-Pinto Belis

    2010-01-01

    The decrease of the cerebral blood flow below the threshold of autoregulation led to changes of cerebral ischemia and necrosis that traduce in signs and symtoms of focal neurologic dysfunction called acute cerebrovascular symdrome (ACS) or stroke. Two big groups according to its etiology are included in this category the hemorragic that constitue a 20% and the ischemic a 80% of cases. Great interest has wom the ischemic ACS because of its high social burden, being the third cause of no violen...

  3. Cerebral Palsy Litigation

    OpenAIRE

    Sartwelle, Thomas P.; Johnston, James C.

    2015-01-01

    The cardinal driver of cerebral palsy litigation is electronic fetal monitoring, which has continued unabated for 40 years. Electronic fetal monitoring, however, is based on 19th-century childbirth myths, a virtually nonexistent scientific foundation, and has a false positive rate exceeding 99%. It has not affected the incidence of cerebral palsy. Electronic fetal monitoring has, however, increased the cesarian section rate, with the expected increase in mortality and morbidity risks to mothe...

  4. Rehabilitation in cerebral palsy.

    OpenAIRE

    Molnar, G. E.

    1991-01-01

    Cerebral palsy is the most frequent physical disability of childhood onset. Over the past four decades, prevalence has remained remarkably constant at 2 to 3 per 1,000 live births in industrialized countries. In this article I concentrate on the rehabilitation and outcome of patients with cerebral palsy. The epidemiologic, pathogenetic, and diagnostic aspects are highlighted briefly as they pertain to the planning and implementation of the rehabilitation process.

  5. Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities

    DEFF Research Database (Denmark)

    Marstrand, J.R.; Garde, E; Rostrup, Egill;

    2002-01-01

    reported global reductions in cerebral blood flow (CBF) and cerebral vascular reactivity. In this study, we examined localized hemodynamic status to compare WMH to normal appearing white matter (NAWM). METHODS: A group of 21 normal 85-year-old subjects were studied using dynamic contrast-enhanced MRI...... together with administration of acetazolamide. From a combination of anatomic images with different signal weighting, regions of interest were generated corresponding to gray and white matter and WMH. Localized measurements of CBF and cerebral blood volume (CBV) and mean transit time were obtained directly...

  6. Pharmacological and molecular comparison of K(ATP) channels in rat basilar and middle cerebral arteries

    DEFF Research Database (Denmark)

    Ploug, Kenneth Beri; Edvinsson, Lars; Olesen, Jes;

    2006-01-01

    basilar and middle cerebral arteries using quantitative real-time PCR (Polymerase Chain Reaction) and Western blotting, respectively. In the perfusion system, we found no significant responses after luminal application of three K(ATP) channel openers to rat basilar and middle cerebral arteries......ATP-sensitive potassium (K(ATP)) channels play an important role in the regulation of cerebral vascular tone. In vitro studies using synthetic K(ATP) channel openers suggest that the pharmacological profiles differ between rat basilar arteries and rat middle cerebral arteries. To address this issue......, we studied the possible involvement of endothelial K(ATP) channels by pressurized arteriography after luminal administration of synthetic K(ATP) channel openers to rat basilar and middle cerebral arteries. Furthermore, we examined the mRNA and protein expression profile of K(ATP) channels to rat...

  7. Pharmacological and molecular comparison of K(ATP) channels in rat basilar and middle cerebral arteries

    DEFF Research Database (Denmark)

    Ploug, Kenneth Beri; Edvinsson, Lars; Olesen, Jes;

    2006-01-01

    ATP-sensitive potassium (K(ATP)) channels play an important role in the regulation of cerebral vascular tone. In vitro studies using synthetic K(ATP) channel openers suggest that the pharmacological profiles differ between rat basilar arteries and rat middle cerebral arteries. To address this issue......, we studied the possible involvement of endothelial K(ATP) channels by pressurized arteriography after luminal administration of synthetic K(ATP) channel openers to rat basilar and middle cerebral arteries. Furthermore, we examined the mRNA and protein expression profile of K(ATP) channels to rat...... basilar and middle cerebral arteries using quantitative real-time PCR (Polymerase Chain Reaction) and Western blotting, respectively. In the perfusion system, we found no significant responses after luminal application of three K(ATP) channel openers to rat basilar and middle cerebral arteries. In...

  8. Cerebral palsy and congenital malformations

    DEFF Research Database (Denmark)

    Garne, Ester; Dolk, Helen; Krägeloh-Mann, Inge;

    2007-01-01

    AIM: To determine the proportion of children with cerebral palsy (CP) who have cerebral and non-cerebral congenital malformations. METHODS: Data from 11 CP registries contributing to the European Cerebral Palsy Database (SCPE), for children born in the period 1976-1996. The malformations were...... classified as recognized syndromes, chromosomal anomalies, cerebral malformations or non-cerebral malformations. Prevalence of malformations was compared to published data on livebirths from a European database of congenital malformations (EUROCAT). RESULTS: Overall 547 out of 4584 children (11.9%) with CP...... were reported to have a congenital malformation. The majority (8.6% of all children) were diagnosed with a cerebral malformation. The most frequent types of cerebral malformations w