WorldWideScience

Sample records for acid-repressible multifaceted defense

  1. Pseudomonas fluorescens WCS374r-induced systemic resistance in rice against Magnaporthe oryzae is based on pseudobactin-mediated priming for a salicylic acid-repressible multifaceted defense response.

    Science.gov (United States)

    De Vleesschauwer, David; Djavaheri, Mohammad; Bakker, Peter A H M; Höfte, Monica

    2008-12-01

    Selected strains of nonpathogenic rhizobacteria can reduce disease in foliar tissues through the induction of a defense state known as induced systemic resistance (ISR). Compared with the large body of information on ISR in dicotyledonous plants, little is known about the mechanisms underlying rhizobacteria-induced resistance in cereal crops. Here, we demonstrate the ability of Pseudomonas fluorescens WCS374r to trigger ISR in rice (Oryza sativa) against the leaf blast pathogen Magnaporthe oryzae. Using salicylic acid (SA)-nonaccumulating NahG rice, an ethylene-insensitive OsEIN2 antisense line, and the jasmonate-deficient mutant hebiba, we show that this WCS374r-induced resistance is regulated by an SA-independent but jasmonic acid/ethylene-modulated signal transduction pathway. Bacterial mutant analysis uncovered a pseudobactin-type siderophore as the crucial determinant responsible for ISR elicitation. Root application of WCS374r-derived pseudobactin (Psb374) primed naive leaves for accelerated expression of a pronounced multifaceted defense response, consisting of rapid recruitment of phenolic compounds at sites of pathogen entry, concerted expression of a diverse set of structural defenses, and a timely hyperinduction of hydrogen peroxide formation putatively driving cell wall fortification. Exogenous SA application alleviated this Psb374-modulated defense priming, while Psb374 pretreatment antagonized infection-induced transcription of SA-responsive PR genes, suggesting that the Psb374- and SA-modulated signaling pathways are mutually antagonistic. Interestingly, in sharp contrast to WCS374r-mediated ISR, chemical induction of blast resistance by the SA analog benzothiadiazole was independent of jasmonic acid/ethylene signaling and involved the potentiation of SA-responsive gene expression. Together, these results offer novel insights into the signaling circuitry governing induced resistance against M. oryzae and suggest that rice is endowed with multiple

  2. Multifaceted defense against antagonistic microbes in developing offspring of the parasitoid wasp Ampulex compressa (Hymenoptera, Ampulicidae.

    Directory of Open Access Journals (Sweden)

    Katharina Weiss

    Full Text Available Effective antimicrobial strategies are essential adaptations of insects to protect themselves, their offspring, and their foods from microbial pathogens and decomposers. Larvae of the emerald cockroach wasp, Ampulex compressa, sanitize their cockroach hosts, Periplaneta americana, with a cocktail of nine antimicrobials comprising mainly (R-(--mellein and micromolide. The blend of these antimicrobials has broad-spectrum antimicrobial activity. Here we explore the spatio-temporal pattern of deployment of antimicrobials during the development from egg to adult as well as their physico-chemical properties to assess how these aspects may contribute to the success of the antimicrobial strategy. Using gas chromatography/mass spectrometry (GC/MS we show that larvae start sanitizing their food as soon as they have entered their host to feed on its tissue. Subsequently, they impregnate the cockroach carcass with antimicrobials to create a hygienic substrate for cocoon spinning inside the host. Finally, the antimicrobials are incorporated into the cocoon. The antimicrobial profiles on cockroach and wasp cocoon differed markedly. While micromolide persisted on the cockroaches until emergence of the wasps, solid-phase microextraction sampling and GC/MS analysis revealed that (R-(--mellein vaporized from the cockroaches and accumulated in the enclosed nest. In microbial challenge assays (R-(--mellein in the headspace of parasitized cockroaches inhibited growth of entomopathogenic and opportunistic microbes (Serratia marcescens, Aspergillus sydowii, Metarhizium brunneum. We conclude that, in addition to food sanitation, A. compressa larvae enclose themselves in two defensive walls by impregnating the cocoon and the cockroach cuticle with antimicrobials. On top of that, they use vaporous (R-(--mellein to sanitize the nest by fumigation. This multifaceted antimicrobial defense strategy involving the spatially and temporally coordinated deployment of several

  3. Multifaceted Approaches to Music Information Retrieval

    NARCIS (Netherlands)

    Liem, C.C.S.

    2015-01-01

    Music is a multifaceted phenomenon: beyond addressing our auditory channel, the consumption of music triggers further senses. Also in creating and communicating music, multiple modalities are at play. Next to this, it allows for various ways of interpretation: the same musical piece can be performed

  4. Multifaceted Approaches to Music Information Retrieval

    NARCIS (Netherlands)

    Liem, C.C.S.

    2015-01-01

    Music is a multifaceted phenomenon: beyond addressing our auditory channel, the consumption of music triggers further senses. Also in creating and communicating music, multiple modalities are at play. Next to this, it allows for various ways of interpretation: the same musical piece can be performed

  5. Tattoo: a multifaceted medium of communication

    Directory of Open Access Journals (Sweden)

    Christian Wymann

    2010-11-01

    Full Text Available This article suggests the systems theoretical distinction of form/medium as a useful tool for distinguishing social phenomena that might look as if they stem from the same process. This is shown to be the case for the tattoo and tattooing. The tattoo is conceived as a medium of communication through which different forms of communication emerge. Tattooing is one of these forms of communication that shapes the medium in a particular way. The current article sheds a special light on its intricate, communicational constellation, for which the concept of parallax is suggested. Law, medicine and cosmetics as other forms of communication use the medium of tattoo in their own way as well. The form/medium distinction allows us to grasp these different forms of communication, while it shows that they share the tattoo as medium. The article’s ultimate goal is to illustrate that the tattoo figures as a multifaceted medium of communication.

  6. Multifaceted Schwinger effect in de Sitter space

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    Sharma, Ramkishor; Singh, Suprit

    2017-07-01

    We investigate particle production à la the Schwinger mechanism in an expanding, flat de Sitter patch as is relevant for the inflationary epoch of our Universe. Defining states and particle content in curved spacetime is certainly not a unique process. There being different prescriptions on how that can be done, we have used the Schrödinger formalism to define instantaneous particle content of the state, etc. This allows us to go past the adiabatic regime to which the effect has been restricted in the previous studies and bring out its multifaceted nature in different settings. Each of these settings gives rise to contrasting features and behavior as per the effect of the electric field and expansion rate on the instantaneous mean particle number. We also quantify the degree of classicality of the process during its evolution using a "classicality parameter" constructed out of parameters of the Wigner function to obtain information about the quantum to classical transition in this case.

  7. Artificial Dendritic Cells: Multi-faceted Perspectives

    CERN Document Server

    Greensmith, Julie

    2009-01-01

    Dendritic cells are the crime scene investigators of the human immune system. Their function is to correlate potentially anomalous invading entities with observed damage to the body. The detection of such invaders by dendritic cells results in the activation of the adaptive immune system, eventually leading to the removal of the invader from the host body. This mechanism has provided inspiration for the development of a novel bio-inspired algorithm, the Dendritic Cell Algorithm. This algorithm processes information at multiple levels of resolution, resulting in the creation of information granules of variable structure. In this chapter we examine the multi-faceted nature of immunology and how research in this field has shaped the function of the resulting Dendritic Cell Algorithm. A brief overview of the algorithm is given in combination with the details of the processes used for its development. The chapter is concluded with a discussion of the parallels between our understanding of the human immune system a...

  8. A multifaceted approach to hydrogen storage.

    Science.gov (United States)

    Churchard, Andrew J; Banach, Ewa; Borgschulte, Andreas; Caputo, Riccarda; Chen, Jian-Cheng; Clary, David; Fijalkowski, Karol J; Geerlings, Hans; Genova, Radostina V; Grochala, Wojciech; Jaroń, Tomasz; Juanes-Marcos, Juan Carlos; Kasemo, Bengt; Kroes, Geert-Jan; Ljubić, Ivan; Naujoks, Nicola; Nørskov, Jens K; Olsen, Roar A; Pendolino, Flavio; Remhof, Arndt; Románszki, Loránd; Tekin, Adem; Vegge, Tejs; Zäch, Michael; Züttel, Andreas

    2011-10-14

    The widespread adoption of hydrogen as an energy carrier could bring significant benefits, but only if a number of currently intractable problems can be overcome. Not the least of these is the problem of storage, particularly when aimed at use onboard light-vehicles. The aim of this overview is to look in depth at a number of areas linked by the recently concluded HYDROGEN research network, representing an intentionally multi-faceted selection with the goal of advancing the field on a number of fronts simultaneously. For the general reader we provide a concise outline of the main approaches to storing hydrogen before moving on to detailed reviews of recent research in the solid chemical storage of hydrogen, and so provide an entry point for the interested reader on these diverse topics. The subjects covered include: the mechanisms of Ti catalysis in alanates; the kinetics of the borohydrides and the resulting limitations; novel transition metal catalysts for use with complex hydrides; less common borohydrides; protic-hydridic stores; metal ammines and novel approaches to nano-confined metal hydrides.

  9. Managing a Bone Healthy Lifestyle After Attending Multifaceted Group Education

    DEFF Research Database (Denmark)

    Jensen, Annesofie Lunde; Lomborg, Kirsten; Langdahl, Bente Lomholt

    2016-01-01

    We examined patients with osteoporosis implementation of recommendations regarding a bone healthy lifestyle after the patients attended multifaceted osteoporosis group education (GE). Our findings suggest that GE can support and influence patients’ transfer of preventive actions. Still patients...... diagnosed with osteoporosis who attended multifaceted GE at a Danish hospital participated. Data consisted of field work and individual interviews in the participants’ everyday environment after completion of GE. After attending multifaceted GE, participants experienced increased attention to and reflected....... On the contrary, attending GE was in some cases not sufficient to overcome social and physical concerns, or to eliminate uncertainty about recommendations or to make participants identify with the osteoporosis diagnosis, which thus impeded implementation of a bone healthy lifestyle. Attending multifaceted GE can...

  10. Hydrothermal growth of multi-facet anatase spheres

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    Wu, Jin-Ming; Song, Xiao-Mei; Ma, Lu-Yao; Wei, Xiao-Dan

    2011-03-01

    Titania with various nanostructures can be synthesized by several F --mediated procedures. In this paper, we report the synthesis of a novel multi-facet microsphere consisting of etched single-crystalline anatase by simply immersing metallic Ti plates in an HF aqueous solution under hydrothermal conditions. The etched multi-facet sphere was found to grow through the nucleation and growth of truncated bipyramids on a previously precipitated one to assemble a microsphere, and its subsequent etching by HF to expose the thermodynamic stable {1 0 1} facets. The photocatalytic activity of such etched multi-facet sphere thin films was evaluated utilizing rhodamine B and sulfonic salicylic acid in water as target molecules and compared with commercial Degussa P25 titania nanoparticles.

  11. TwNC: a Multifaceted Dutch News Corpus

    NARCIS (Netherlands)

    Ordelman, Roeland; Jong, de Franciska; Hessen, van Arjan; Hondorp, Hendri

    2007-01-01

    This contribution describes the Twente News Corpus (TwNC), a multifaceted corpus for Dutch that is being deployed in a number of NLP research projects among which tracks within the Dutch national research programme MultimediaN, the NWO programme CATCH, and the Dutch-Flemish programme STEVIN. The de

  12. Chips for Everyone: A Multifaceted Approach in Electrical Engineering Outreach

    Science.gov (United States)

    Magill, J.; Roy, S.

    2010-01-01

    This paper reports on a multifaceted approach in electrical engineering outreach focused on the area of semiconductor technology. The activities developed can be used in combination for a very wide range of audiences in both age and stage of education, as has been demonstrated with great success. Moreover, the project has developed…

  13. [Multi-facetted clinical presentation of thrombotic thrombocytopenic purpura

    DEFF Research Database (Denmark)

    Niemann, C.U.; Jurlander, J.; Daugaard, G.

    2009-01-01

    smears. Determination of the ADAMTS13-activity is now becoming available as a routine analysis. We present two cases that illustrate the multi-facetted clinical presentation under which TTP occurs. The importance of access to ADAMTS13 measurements is stressed Udgivelsesdato: 2009/1/26...

  14. Multifaceted toxicity assessment of catalyst composites in transgenic zebrafish embryos.

    Science.gov (United States)

    Jang, Gun Hyuk; Lee, Keon Yong; Choi, Jaewon; Kim, Sang Hoon; Lee, Kwan Hyi

    2016-09-01

    Recent development in the field of nanomaterials has given rise into the inquiries regarding the toxicological characteristics of the nanomaterials. While many individual nanomaterials have been screened for their toxicological effects, composites that accompany nanomaterials are not common subjects to such screening through toxicological assessment. One of the widely used composites that accompany nanomaterials is catalyst composite used to reduce air pollution, which was selected as a target composite with nanomaterials for the multifaceted toxicological assessment. As existing studies did not possess any significant data regarding such catalyst composites, this study focuses on investigating toxicological characteristics of catalyst composites from various angles in both in-vitro and in-vivo settings. Initial toxicological assessment on catalyst composites was conducted using HUVECs for cell viability assays, and subsequent in-vivo assay regarding their direct influence on living organisms was done. The zebrafish embryo and its transgenic lines were used in the in-vivo assays to obtain multifaceted analytic results. Data obtained from the in-vivo assays include blood vessel formation, mutated heart morphology, and heart functionality change. Our multifaceted toxicological assessment pointed out that chemical composites augmented with nanomaterials can too have toxicological threat as much as individual nanomaterials do and alarms us with their danger. This manuscript provides a multifaceted assessment for composites augmented with nanomaterials, of which their toxicological threats have been overlooked.

  15. Measuring the Multifaceted Nature of Infant and Toddler Care Quality

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    Mangione, Peter L.; Kriener-Althen, Kerry; Marcella, Jennifer

    2016-01-01

    Research Findings: The quality of group care infants and toddlers experience relates to their concurrent and later development. Recent quality improvement initiatives point to the need for ecologically valid measures that assess the multifaceted nature of child care quality. In this article, we present the psychometric properties of an infant and…

  16. FacetAtlas: multifaceted visualization for rich text corpora.

    Science.gov (United States)

    Cao, Nan; Sun, Jimeng; Lin, Yu-Ru; Gotz, David; Liu, Shixia; Qu, Huamin

    2010-01-01

    Documents in rich text corpora usually contain multiple facets of information. For example, an article about a specific disease often consists of different facets such as symptom, treatment, cause, diagnosis, prognosis, and prevention. Thus, documents may have different relations based on different facets. Powerful search tools have been developed to help users locate lists of individual documents that are most related to specific keywords. However, there is a lack of effective analysis tools that reveal the multifaceted relations of documents within or cross the document clusters. In this paper, we present FacetAtlas, a multifaceted visualization technique for visually analyzing rich text corpora. FacetAtlas combines search technology with advanced visual analytical tools to convey both global and local patterns simultaneously. We describe several unique aspects of FacetAtlas, including (1) node cliques and multifaceted edges, (2) an optimized density map, and (3) automated opacity pattern enhancement for highlighting visual patterns, (4) interactive context switch between facets. In addition, we demonstrate the power of FacetAtlas through a case study that targets patient education in the health care domain. Our evaluation shows the benefits of this work, especially in support of complex multifaceted data analysis.

  17. Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.

    Science.gov (United States)

    Manils, Joan; Gómez, Diana; Salla-Martret, Mercè; Fischer, Heinz; Fye, Jason M; Marzo, Elena; Marruecos, Laura; Serrano, Inma; Salgado, Rocío; Rodrigo, Juan P; Garcia-Pedrero, Juana M; Serafin, Anna M; Cañas, Xavier; Benito, Carmen; Toll, Agustí; Forcales, Sònia-Vanina; Perrino, Fred W; Eckhart, Leopold; Soler, Concepció

    2015-09-08

    TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic UV exposure whereas it was de-regulated or lost in human squamous cell carcinomas (SCCs). Moreover, we identified SNPs in the TREX2 gene that were more frequent in patients with head and neck SCCs than in healthy individuals. In mice, TREX2 deficiency led to enhanced susceptibility to UVB-induced skin carcinogenesis which was preceded by aberrant DNA damage removal and degradation as well as reduced inflammation. Specifically, TREX2 loss diminished the up-regulation of IL12 and IFNγ, key cytokines related to DNA repair and antitumor immunity. In UV-treated keratinocytes, TREX2 promoted DNA repair and passage to late apoptotic stages. Notably, TREX2 was recruited to low-density nuclear chromatin and micronuclei, where it interacted with phosphorylated H2AX histone, which is a critical player in both DNA repair and cell death. Altogether, our data provide new insights in the molecular mechanisms of TREX2 activity and establish cell autonomous and non-cell autonomous functions of TREX2 in the UVB-induced skin response.

  18. Multifaceted Applications of Chitosan in Cancer Drug Delivery and Therapy.

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    Babu, Anish; Ramesh, Rajagopal

    2017-03-27

    Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible and biodegradable nature of chitosan, it is intensively utilized in biomedical applications in scaffold engineering as an absorption enhancer, and for bioactive and controlled drug release. In cancer therapy, chitosan has multifaceted applications, such as assisting in gene delivery and chemotherapeutic delivery, and as an immunoadjuvant for vaccines. The present review highlights the recent applications of chitosan and chitosan derivatives in cancer therapy.

  19. Development of a Multifaceted Ovarian Cancer Imaging Agent

    Science.gov (United States)

    2010-04-01

    method for a recombinant disintegrin vicrostatin (VN), whose structure is based on the snake venom disintegrin contortrostatin (CN), and the use of the...TITLE: Development of a Multifaceted Ovarian Cancer Imaging Agent PRINCIPAL INVESTIGATOR: Francis S . Markland Ph.D...distribution unlimited The views, opinions and/or findings contained in this report are those of the author( s ) and should not be construed

  20. Multifaceted Applications of Chitosan in Cancer Drug Delivery and Therapy

    Directory of Open Access Journals (Sweden)

    Anish Babu

    2017-03-01

    Full Text Available Chitosan is a versatile polysaccharide of biological origin. Due to the biocompatible and biodegradable nature of chitosan, it is intensively utilized in biomedical applications in scaffold engineering as an absorption enhancer, and for bioactive and controlled drug release. In cancer therapy, chitosan has multifaceted applications, such as assisting in gene delivery and chemotherapeutic delivery, and as an immunoadjuvant for vaccines. The present review highlights the recent applications of chitosan and chitosan derivatives in cancer therapy.

  1. Antioxidative defense

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    Stevanović Jelka

    2011-01-01

    Full Text Available Free radicals occur constantly during metabolism and take part in numerous physiological processes, such as: intra-cellular and inter-cellular signalization, gene expression, removal of damaged or senescent cells, and control of the tone of blood vessels. However, there is an increased quantity of free radicals in situations of so-called oxidative stress, when they cause serious damage to cellular membranes (peroxidation of their lipids, damage of membrane proteins, and similar, to interior cellular protein molecules, as well as DNA molecules and carbohydrates. This is precisely why the organism has developed numerous mechanisms for removing free radicals and/or preventing their production. Some of these are enzyme-related and include superoxide-dismutase, catalase, glutathione-peroxidase, and others. Other, non-enzyme mechanisms, imply antioxidative activities of vitamins E and C, provitamin A, coenzyme Q, reduced glutation, and others. Since free radicals can leave the cell that has produced them and become dispersed throughout the body, in addition to antioxidative defense that functions within cellular structures, antioxidant extra-cellular defense has also been developed. This is comprised by: transferrin, lactoferrin, haptoglobin, hemopexin, ceruloplasmin, albumins, extra-cellular isoform SOD, extracellular glutathione-peroxidase, glucose, bilirubin, urates, and many other molecules.

  2. Multifaceted Approach to Personality Assessment in Cheetahs (Acinonyx jubatus

    Directory of Open Access Journals (Sweden)

    Catherine B. Razal

    2016-02-01

    Full Text Available The purpose of this study was to assess the personality of 17 South African cheetahs at the San Diego Zoo Safari Park. A multifaceted approach of observer ratings (rating method, behavioral data (coding method and hormone monitoring was used to examine individual differences. Knowledge of these individual differences, i.e., personality, is essential to better husbandry and management in a zoological facility. Principal Components Analysis yielded five personality components: Insecure, Aggressive, Interactive, Active, and Unsociable. Comparing the personality components with gender, reproductive success, and hand-rearing history of the individuals revealed significant associations. The components Aggressive and Interactive had a positive correlation with behavioral diversity, and the component Unsociable had a positive correlation with self-maintenance. There was a significant gender difference, with males scoring higher on Aggressive and Interactive. Individuals who scored higher on these components also had higher levels of behavioral diversity, and males displayed higher levels of behavioral diversity than females. In addition, individuals that were reproductively successful scored higher on the component Unsociable, as well as displayed higher FGM levels. This study demonstrates the value of using a multifaceted approach to further understand and assess animal personality. Information gained from this study can ultimately help zoological facilities manage and assist with reproductive efforts in populations that are not currently self-sustaining, such as the cheetah.

  3. A general approach to testing multifaceted personality constructs.

    Science.gov (United States)

    Hull, J G; Lehn, D A; Tedlie, J C

    1991-12-01

    Some personality characteristics are composed of multiple, distinct subcomponents (e.g., Type A, hardiness, attributional style, self-monitoring). The advantages and disadvantages of 3 typical approaches to testing these constructs are reviewed. An alternative approach based on structural equation modeling is then offered. This approach has many advantages over its alternatives, including the provision of an explicit test of the structure of the multifaceted construct, the simultaneous test of the effects of this general construct and the unique aspects of its subcomponents, and the explicit consideration of measurement error. Although the modeling approach does have limitations, these limitations are equally applicable to all of its alternatives. Indeed, the principal disadvantages of the modeling approach seem to be its statistical complexity and the lack of education regarding its proper use.

  4. Understanding Parkinson Disease: A Complex and Multifaceted Illness.

    Science.gov (United States)

    Gopalakrishna, Apoorva; Alexander, Sheila A

    2015-12-01

    Parkinson disease is an incredibly complex and multifaceted illness affecting millions of people in the United States. Parkinson disease is characterized by progressive dopaminergic neuronal dysfunction and loss, leading to debilitating motor, cognitive, and behavioral symptoms. Parkinson disease is an enigmatic illness that is still extensively researched today to search for a better understanding of the disease, develop therapeutic interventions to halt or slow progression of the disease, and optimize patient outcomes. This article aims to examine in detail the normal function of the basal ganglia and dopaminergic neurons in the central nervous system, the etiology and pathophysiology of Parkinson disease, related signs and symptoms, current treatment, and finally, the profound impact of understanding the disease on nursing care.

  5. The Impact of a Multifaceted Approach to Teaching Research Methods on Students' Attitudes

    Science.gov (United States)

    Ciarocco, Natalie J.; Lewandowski, Gary W., Jr.; Van Volkom, Michele

    2013-01-01

    A multifaceted approach to teaching five experimental designs in a research methodology course was tested. Participants included 70 students enrolled in an experimental research methods course in the semester both before and after the implementation of instructional change. When using a multifaceted approach to teaching research methods that…

  6. The Impact of a Multifaceted Approach to Teaching Research Methods on Students' Attitudes

    Science.gov (United States)

    Ciarocco, Natalie J.; Lewandowski, Gary W., Jr.; Van Volkom, Michele

    2013-01-01

    A multifaceted approach to teaching five experimental designs in a research methodology course was tested. Participants included 70 students enrolled in an experimental research methods course in the semester both before and after the implementation of instructional change. When using a multifaceted approach to teaching research methods that…

  7. The Impact of a Multifaceted Approach to Teaching Research Methods on Students' Attitudes

    Science.gov (United States)

    Ciarocco, Natalie J.; Lewandowski, Gary W., Jr.; Van Volkom, Michele

    2013-01-01

    A multifaceted approach to teaching five experimental designs in a research methodology course was tested. Participants included 70 students enrolled in an experimental research methods course in the semester both before and after the implementation of instructional change. When using a multifaceted approach to teaching research methods that…

  8. Long-Term Results of an Individualized, Multifaceted, and Multidisciplinary Therapeutic Approach to Provoked Vestibulodynia

    NARCIS (Netherlands)

    Spoelstra, Symen K.; Dijkstra, Jeroen R.; van Driel, Mels F.; Schultz, Willibrord C. M. Weijmar

    2011-01-01

    Introduction. Although it is highly recommended to use a multifaceted approach to treat provoked vestibulodynia (PVD), the large majority of treatment studies on PVD used a one-dimensional approach. Aim. To evaluate the long-term treatment outcome of a multifaceted approach to vulvar pain, sexual fu

  9. Sexual Desire in Sexual Minority and Majority Women and Men: The Multifaceted Sexual Desire Questionnaire.

    Science.gov (United States)

    Chadwick, Sara B; Burke, Shannon M; Goldey, Katherine L; Bell, Sarah N; van Anders, Sari M

    2017-01-09

    Sexual desire is increasingly understood to be multifaceted and not solely erotically oriented, but measures are still generally unitary and eroticism-focused. Our goals in this article were to explore the multifaceted nature of sexual desire and develop a measure to do so, and to determine how multifaceted sexual desire might be related to gender/sex and sexual orientation/identity. In the development phase, we generated items to form the 65-item Sexual Desire Questionnaire (DESQ). Next, the DESQ was administered to 609 women, 705 men, and 39 non-binary identified participants. Results showed that the DESQ demonstrated high reliability and validity, and that sexual desire was neither unitary nor entirely erotic, but instead was remarkably multifaceted. We also found that multifaceted sexual desire was in part related to social location variables such as gender/sex and sexual orientation/identity. We propose the DESQ as a measure of multifaceted sexual desire that can be used to compare factor themes, total scores, and scores across individual items in diverse groups that take social context into account. Results are discussed in light of how social location variables should be considered when making generalizations about sexual desire, and how conceptualizations of desire as multifaceted may provide important insights.

  10. Towards informed and multi-faceted wildlife trade interventions

    Directory of Open Access Journals (Sweden)

    Daniel W.S. Challender

    2015-01-01

    Full Text Available International trade in wildlife is a key threat to biodiversity conservation. CITES, the Convention on International Trade in Endangered Species of Wild Fauna and Flora, seeks to ensure international wildlife trade is sustainable, relying on trade bans and controls. However, there has been little comprehensive review of its effectiveness and here we review approaches taken to regulate wildlife trade in CITES. Although assessing its effectiveness is problematic, we assert that CITES boasts few measurable conservation successes. We attribute this to: non-compliance, an over reliance on regulation, lack of knowledge and monitoring of listed species, ignorance of market forces, and influence among CITES actors. To more effectively manage trade we argue that interventions should go beyond regulation and should be multi-faceted, reflecting the complexity of wildlife trade. To inform these interventions we assert an intensive research effort is needed around six key areas: (1 factors undermining wildlife trade governance at the national level, (2 determining sustainable harvest rates for, and adaptive management of CITES species, (3 gaining the buy-in of local communities in implementing CITES, (4 supply and demand based market interventions, (5 means of quantifying illicit trade, and (6 political processes and influence within CITES.

  11. CSP: A Multifaceted Hybrid Architecture for Space Computing

    Science.gov (United States)

    Rudolph, Dylan; Wilson, Christopher; Stewart, Jacob; Gauvin, Patrick; George, Alan; Lam, Herman; Crum, Gary Alex; Wirthlin, Mike; Wilson, Alex; Stoddard, Aaron

    2014-01-01

    Research on the CHREC Space Processor (CSP) takes a multifaceted hybrid approach to embedded space computing. Working closely with the NASA Goddard SpaceCube team, researchers at the National Science Foundation (NSF) Center for High-Performance Reconfigurable Computing (CHREC) at the University of Florida and Brigham Young University are developing hybrid space computers that feature an innovative combination of three technologies: commercial-off-the-shelf (COTS) devices, radiation-hardened (RadHard) devices, and fault-tolerant computing. Modern COTS processors provide the utmost in performance and energy-efficiency but are susceptible to ionizing radiation in space, whereas RadHard processors are virtually immune to this radiation but are more expensive, larger, less energy-efficient, and generations behind in speed and functionality. By featuring COTS devices to perform the critical data processing, supported by simpler RadHard devices that monitor and manage the COTS devices, and augmented with novel uses of fault-tolerant hardware, software, information, and networking within and between COTS devices, the resulting system can maximize performance and reliability while minimizing energy consumption and cost. NASA Goddard has adopted the CSP concept and technology with plans underway to feature flight-ready CSP boards on two upcoming space missions.

  12. A multifaceted hospital-wide intervention increases hand hygiene compliance.

    Science.gov (United States)

    Patel, B; Engelbrecht, H; McDonald, H; Morris, V; Smythe, W

    2016-03-07

    Hand hygiene is an important and basic practice that should be used by all healthcare staff to protect both themselves and their patients against infection. Unfortunately hand hygiene compliance remains poor. To show an improvement in hand hygiene compliance using a multifaceted approach. This was a quasiexperimental pre-post intervention study design with a number of standardised interventions to promote hand hygiene. The World Health Organization hand hygiene multimodal (five-step) intervention approach was used. The study ran from June 2015 to August 2015 in 11 selected wards of a 975-bed tertiary and quaternary care public hospital (Groote Schuur Hospital, Cape Town, South Africa). The outcome was to assess improvement in hand hygiene compliance monthly over the 3 months, compared with non-intervention wards and compared with the wards' own performance measured in 2014. The study included both descriptive and analytical components. Post intervention, hand hygiene compliance showed a statistically significant improvement for before patient contact from 34% in 2014 to 76% in 2015 (p<0.05) and for after patient contact from 47% in 2014 to 82% in 2015 (p<0.05). The intervention improved hand hygiene compliance and can easily be replicated in other wards, resulting in sustaining a culture of hand hygiene improvement and behavioural change throughout the hospital.

  13. Multifaceted role of prohibitin in cell survival and apoptosis.

    Science.gov (United States)

    Peng, Ya-Ting; Chen, Ping; Ouyang, Ruo-Yun; Song, Lei

    2015-09-01

    Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis.

  14. Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.

    Science.gov (United States)

    Troeberg, Linda; Fushimi, Kazunari; Khokha, Rama; Emonard, Hervé; Ghosh, Peter; Nagase, Hideaki

    2008-10-01

    Degradation of the cartilage proteoglycan aggrecan is a key early event in the development of osteoarthritis. Adamalysin with thrombospondin motifs (ADAMTS) -4 and ADAMTS-5 are considered to be the main enzymes responsible for aggrecan breakdown, making them attractive drugs targets. Here we show that calcium pentosan polysulfate (CaPPS), a chemically sulfated xylanopyranose from beechwood, is a multifaceted exosite inhibitor of the aggrecanases and protects cartilage against aggrecan degradation. CaPPS interacts with the noncatalytic spacer domain of ADAMTS-4 and the cysteine-rich domain of ADAMTS-5, blocking activity against their natural substrate aggrecan with inhibitory concentration 50 values of 10-40 nM but only weakly inhibiting hydrolysis of a nonglycosylated recombinant protein substrate. In addition, CaPPS increased cartilage levels of tissue inhibitor of metalloproteinases-3 (TIMP-3), an endogenous inhibitor of ADAMTS-4 and -5. This was due to the ability of CaPPS to block endocytosis of TIMP-3 mediated by low-density lipoprotein receptor-related protein. CaPPS also increased the affinity of TIMP-3 for ADAMTS-4 and -5 by more than 100-fold, improving the efficacy of TIMP-3 as an aggrecanase inhibitor. Studies with TIMP-3-null mouse cartilage indicated that CaPPS inhibition of aggrecan degradation is TIMP-3 dependent. These unique properties make CaPPS a prototypic disease-modifying agent for osteoarthritis.

  15. Multifaceted Impacts of Sustainable Land Management in Drylands: A Review

    Directory of Open Access Journals (Sweden)

    Maria Jose Marques

    2016-02-01

    Full Text Available Biophysical restoration or rehabilitation measures of land have demonstrated to be effective in many scientific projects and small-scale environmental experiments. However circumstances such as poverty, weak policies, or inefficient scientific knowledge transmission can hinder the effective upscaling of land restoration and the long term maintenance of proven sustainable use of soil and water. This may be especially worrisome in lands with harsh environmental conditions. This review covers recent efforts in landscape restoration and rehabilitation with a functional perspective aiming to simultaneously achieve ecosystem sustainability, economic efficiency, and social wellbeing. Water management and rehabilitation of ecosystem services in croplands, rangelands, forests, and coastlands are reviewed. The joint analysis of such diverse ecosystems provides a wide perspective to determine: (i multifaceted impacts on biophysical and socio-economic factors; and (ii elements influencing effective upscaling of sustainable land management practices. One conclusion can be highlighted: voluntary adoption is based on different pillars, i.e. external material and economic support, and spread of success information at the local scale to demonstrate the multidimensional benefits of sustainable land management. For the successful upscaling of land management, more attention must be paid to the social system from the first involvement stage, up to the long term maintenance.

  16. A multifaceted education intervention for improving family physicians' case management.

    Science.gov (United States)

    Reyes-Morales, Hortensia; Flores-Hernández, Sergio; Tomé-Sandoval, Patricia; Pérez-Cuevas, Ricardo

    2009-04-01

    The Mexican Institute of Social Security (IMSS) is the largest public health care system in Mexico. IMSS family physicians' management of clinical problems is frequently not consistent with published evidence. This study aimed to evaluate the effects of a multifaceted educational intervention to improve management of acute respiratory infections (ARI) by IMSS family physicians. A non-randomized pre-post intervention with comparison group design was conducted in eight IMSS family medicine clinics in which 106 family physicians practiced. An evidence-based clinical guideline for ARI management was developed, and clinical tutors were trained. The three-stage intervention comprised interactive workshops, individual tutorials, and round-table peer-review sessions. The main outcome was appropriate ARI case management. The intervention effect was calculated by using the differences-in-differences model, adjusting for cluster of physicians. In the intervention group, the difference in mean proportion of improvement compared with baseline evaluation was 22.6% (95% confidence interval [CI]=10.3 to 34.9) for appropriate prescription of antibiotics, 29.8% (95% CI=17.2 to 42.4) for indication of worsening signs, and 19.6% (95% CI=11.2 to 28.0) for overall appropriate case management. The comparison group showed no significant changes. The educational intervention improved ARI management. Further studies are needed to analyze organizational implications, cost, sustainability, and effects on health outcomes.

  17. The multifaceted roles of FLOWERING LOCUS T in plant development.

    Science.gov (United States)

    Pin, P A; Nilsson, O

    2012-10-01

    One of the key developmental processes in flowering plants is the differentiation of the shoot apical meristem into a floral meristem. This transition is regulated through the integration of environmental and endogenous stimuli, involving a complex, hierarchical signalling network. In arabidopsis, the FLOWERING LOCUS T (FT) protein, a mobile signal recognized as a major component of florigen, has a central position in mediating the onset of flowering. FT-like genes seem to be involved in regulating the floral transition in all angiosperms examined to date. Evidence from molecular evolution studies suggests that the emergence of FT-like genes coincided with the evolution of the flowering plants. Hence, the role of FT in floral promotion is conserved, but appears to be restricted to the angiosperms. Besides flowering, FT-like proteins have also been identified as major regulatory factors in a wide range of developmental processes including fruit set, vegetative growth, stomatal control and tuberization. These multifaceted roles of FT-like proteins have resulted from extensive gene duplication events, which occurred independently in nearly all modern angiosperm lineages, followed by sub- or neo-functionalization. This review assesses the plethora of roles that FT-like genes have acquired during evolution and their implications in plant diversity, adaptation and domestication.

  18. Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia.

    Science.gov (United States)

    Tyrrell, J; Whelan, N; Wright, C; Sá-Correia, I; McClean, S; Thomas, M; Callaghan, Máire

    2015-04-01

    Burkholderia cenocepacia is a bacterial pathogen which causes severe respiratory infections in cystic fibrosis (CF). These studies were aimed at gaining an insight into the iron acquisition strategies of B. cenocepacia. In iron restricted conditions, genes associated with the synthesis and utilisation of ornibactin (pvdA, orbA, orb F) were significantly upregulated compared to the expression of pyochelin associated genes (pchD, fptA). In the absence of alternative iron sources, B. cenocepacia J2315 and 715j utilised ferritin and haemin, but not transferrin or lactoferrin for growth. Significantly, mutants unable to produce ornibactin, (715j-orbI) or ornibactin and pyochelin, (715j-pobA), utilised haemin and ferritin more efficiently than the wild-type. Moreover, both mutants were also able to utilise lactoferrin for growth (P ≤ 0.01) and additionally 715j-pobA utilised transferrin (P ≤ 0.01), potentially facilitating adaptation to the host environment. Furthermore, B. cenocepacia increased ornibactin gene expression in response to pyoverdine from Pseudomonas aeruginosa (P ≤ 0.01), demonstrating the capacity to compete for iron in co-colonised niches. Pyoverdine also significantly diminished the growth of B. cenocepacia (P < 0.001) which was related to its iron chelating activity. In a study of three B. cenocepacia sequential clonal isolates obtained from a CF patient over a 3.5 year period, ornibactin upregulation in response to pyoverdine was less pronounced in the last isolate compared to the earlier isolates, as was growth in the presence of haemin and ferritin, indicating alternative iron acquisition mechanism(s) may dominate as chronic infection progresses. These data demonstrate the multifaceted iron acquisition strategies of B. cenocepacia and their capacity to be differentially activated in the presence of P. aeruginosa and during chronic infection.

  19. Credit use: psychological perspectives on a multifaceted phenomenon.

    Science.gov (United States)

    Kamleitner, Bernadette; Hoelzl, Erik; Kirchler, Erich

    2012-01-01

    Consumer borrowing is a highly topical and multifaceted phenomenon as well as a popular subject for study. We focus on consumer credit use and review the existing literature. To categorize what is known we identify four main psychological perspectives on the phenomenon: credit use as (1) a reflection of the situation, (2) a reflection of the person, (3) a cognitive process, and (4) a social process. On top of these perspectives we view credit use as a process that entails three distinct phases: (1) processes before credit acquisition, (2) processes at credit acquisition, and (3) processes after credit acquisition. We review the international literature along a two-tier structure that aligns the psychological perspectives with a process view of credit. This structure allows us to identify systematic concentrations as well as gaps in the existing research. We consolidate what is known within each perspective and identify what seems to be most urgently missing. Some of the most important gaps relate to research studying credit acquisition from the perspective of credit use as a reflection of the person or as a social process. In particular, research on credit use as a reflection of the person appears to focus exclusively on the first stage of the credit process. We conclude with a discussion that reaches across perspectives and identifies overarching gaps, trends, and open questions. We highlight a series of implicit linkages between perspectives and the geographical regions in which studies related to the perspectives were conducted. Beyond diagnosing a geographical imbalance of research, we argue for future research that systematically addresses interrelations between perspectives. We conclude with a set of global implications and research recommendations.

  20. MULTI-FACET TRUST MODEL FOR ONLINE SOCIAL NETWORK ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Liu Ban Chieng

    2015-01-01

    Full Text Available Online Social Network (OSN has become the most popular platform on the Internet that can provide an interesting and creative ways to communicate, sharing and meets with peoples. As OSNs mature, issues regarding proper use of OSNs are also growing. In this research, the challenges of online social networks have been investigated. The current issues in some of the Social Network Sites are being studied and compared. Cyber criminals, malware attacks, physical threat, security and usability and some privacy issues have been recognized as the challenges of the current social networking sites. Trust concerns have been raised and the trustworthiness of social networking sites has been questioned. Currently, the trust in social networks is using the single- faceted approach, which is not well personalized, and doesn’t account for the subjective views of trust, according to each user, but only the general trust believes of a group of population. The trust level towards a person cannot be calculated and trust is lack of personalization. From our initial survey, we had found that most people can share their information without any doubts on OSN but they normally do not trust all their friends equally and think there is a need of trust management. We had found mixed opinions in relation to the proposed rating feature in OSNs too. By adopting the idea of multi-faceted trust model, a user-centric model that can personalize the comments/photos in social network with user’s customized traits of trust is proposed. This model can probably solve many of the trust issues towards the social networking sites with personalized trust features, in order to keep the postings on social sites confidential and integrity.

  1. Recognizing plant defense priming

    NARCIS (Netherlands)

    Martinez-Medina, A.; Flors, V.; Heil, M.; Mauch-Mani, B.; Pieterse, C.M.J.; Pozo, M.J.; Ton, J.; Van Dam, N.M.; Conrath, U.

    2016-01-01

    Defense priming conditions diverse plant species for the superinduction of defense, often resulting in enhanced pest and disease resistance and abiotic stress tolerance. Here, we propose a guideline that might assist the plant research community in a consistent assessment of defense priming in plant

  2. Effective and Efficient Multi-Facet Web Image Annotation

    Institute of Scientific and Technical Information of China (English)

    Jia Chen; Yi-He Zhu; Hao-Fen Wang; Wei Jin; Yong Yu

    2012-01-01

    The vast amount of images available on the Web request for an effective and efficient search service to help users find relevant images.The prevalent way is to provide a keyword interface for users to submit queries.However,the amount of images without any tags or annotations are beyond the reach of manual efforts.To overcome this,automatic image annotation techniques emerge,which are generally a process of selecting a suitable set of tags for a given image without user intervention.However,there are three main challenges with respect to Web-scale image annotation:scalability,noiseresistance and diversity.Scalability has a twofold meaning:first an automatic image annotation system should be scalable with respect to billions of images on the Web; second it should be able to automatically identify several relevant tags among a huge tag set for a given image within seconds or even faster.Noise-resistance means that the system should be robust enough against typos and ambiguous terms used in tags.Diversity represents that image content may include both scenes and objects,which are further described by multiple different image features constituting different facets in annotation.In this paper,we propose a unified framework to tackle the above three challenges for automatic Web image annotation.It mainly involves two components:tag candidate retrieval and multi-facet annotation.In the former content-based indexing and concept-based codebook are leveraged to solve scalability and noise-resistance issues.In the latter the joint feature map has been designed to describe different facets of tags in annotations and the relations between these facets.Tag graph is adopted to represent tags in the entire annotation and the structured learning technique is employed to construct a learning model on top of the tag graph based on the generated joint feature map.Millions of images from Flickr are used in our evaluation.Experimental results show that we have achieved 33% performance

  3. Evolution of the multifaceted eukaryotic akirin gene family

    Directory of Open Access Journals (Sweden)

    Johnston Ian A

    2009-02-01

    -acid positions where the rate of evolution had shifted significantly between paralogues. Interestingly, the highest scoring position was within a conserved, validated binding-site for 14-3-3 proteins. Conclusion This work offers an evolutionary framework to facilitate future studies of eukaryotic akirins and provides insight into their multifaceted and conserved biochemical functions.

  4. Multifaceted pathways protect human skin from UV radiation.

    Science.gov (United States)

    Natarajan, Vivek T; Ganju, Parul; Ramkumar, Amrita; Grover, Ritika; Gokhale, Rajesh S

    2014-07-01

    The recurrent interaction of skin with sunlight is an intrinsic constituent of human life, and exhibits both beneficial and detrimental effects. The apparent robust architectural framework of skin conceals remarkable mechanisms that operate at the interface between the surface and environment. In this Review, we discuss three distinct protective mechanisms and response pathways that safeguard skin from deleterious effects of ultraviolet (UV) radiation. The unique stratified epithelial architecture of human skin along with the antioxidant-response pathways constitutes the important defense mechanisms against UV radiation. The intricate pigmentary system and its intersection with the immune-system cytokine axis delicately balance tissue homeostasis. We discuss the relationship among these networks in the context of an unusual depigmenting disorder, vitiligo. The elaborate tunable mechanisms, elegant multilayered architecture and evolutionary selection pressures involved in skin and sunlight interaction makes this a compelling model to understand biological complexity.

  5. Moving Target Defense

    CERN Document Server

    Jajodia, Sushil; Swarup, Vipin; Wang, Cliff; Wang, X Sean

    2011-01-01

    Moving Target Defense: Creating Asymmetric Uncertainty for Cyber Threats was developed by a group of leading researchers. It describes the fundamental challenges facing the research community and identifies new promising solution paths. Moving Target Defense which is motivated by the asymmetric costs borne by cyber defenders takes an advantage afforded to attackers and reverses it to advantage defenders. Moving Target Defense is enabled by technical trends in recent years, including virtualization and workload migration on commodity systems, widespread and redundant network connectivity, instr

  6. Dynamic defense workshop :

    Energy Technology Data Exchange (ETDEWEB)

    Crosby, Sean Michael; Doak, Justin E.; Haas, Jason Juedes.; Helinski, Ryan; Lamb, Christopher C.

    2013-02-01

    On September 5th and 6th, 2012, the Dynamic Defense Workshop: From Research to Practice brought together researchers from academia, industry, and Sandia with the goals of increasing collaboration between Sandia National Laboratories and external organizations, de ning and un- derstanding dynamic, or moving target, defense concepts and directions, and gaining a greater understanding of the state of the art for dynamic defense. Through the workshop, we broadened and re ned our de nition and understanding, identi ed new approaches to inherent challenges, and de ned principles of dynamic defense. Half of the workshop was devoted to presentations of current state-of-the-art work. Presentation topics included areas such as the failure of current defenses, threats, techniques, goals of dynamic defense, theory, foundations of dynamic defense, future directions and open research questions related to dynamic defense. The remainder of the workshop was discussion, which was broken down into sessions on de ning challenges, applications to host or mobile environments, applications to enterprise network environments, exploring research and operational taxonomies, and determining how to apply scienti c rigor to and investigating the eld of dynamic defense.

  7. Unfolding Green Defense

    DEFF Research Database (Denmark)

    Larsen, Kristian Knus

    2015-01-01

    consumption in military operations, defense expenditure, energy security, and global climate change. The report then proceeds to introduce the NATO Green Defence Framework before exploring specific current uses of green technologies and green strategies for defense. The report concludes that a number...

  8. Avian host defense peptides

    NARCIS (Netherlands)

    Cuperus, Tryntsje; Coorens, M.; van Dijk, A.; Haagsman, H.P.

    2013-01-01

    Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense

  9. Defense Mechanisms: A Bibliography.

    Science.gov (United States)

    Pedrini, D. T.; Pedrini, Bonnie C.

    This bibliography includes studies of defense mechanisms, in general, and studies of multiple mechanisms. Defense mechanisms, briefly and simply defined, are the unconscious ego defendants against unpleasure, threat, or anxiety. Sigmund Freud deserves the clinical credit for studying many mechanisms and introducing them in professional literature.…

  10. Defense Industry Clusters in Turkey

    Directory of Open Access Journals (Sweden)

    Kadir Alpaslan Demir

    2016-06-01

    Full Text Available All countries strive for a capable national defense supported by a strong national defense industry. Supporting national defense with imported defense systems has many limitations and risks because the terms of arms trade agreements between countries may easily be influenced by the political climate of the signatories. As a result, establishing an independent national defense requires a strong national defense industry. Furthermore, exporting defense systems may be an important source of national income. National defense industries mostly consist of large-scale defense firms that have the resources required for big defense contracts. However, small to medium enterprises (SMEs do not have the necessary resources, therefore they are at a disadvantage. To overcome this handicap and be part of the business, defense industry clusters mostly consisting of SMEs are being established. Provided that there is good national planning and support in this area, defense clusters consisting of SMEs may play a significant role in industry. SMEs have a chance to offer specialized services, special or customized products when needed. As a result, large defense firms subcontract certain portions of defense projects to SMEs. Since 2010, Turkey has shown signs of continuous improvement in defense industry clustering. In parallel with these developments, this study discusses the importance of clustering in the defense industry, briefly presents the state of the Turkish defense industry as highlighted by national statistics, and presents the current status of defense clusters in Turkey. The novelty of this article consists in its assessment of Turkish defense clusters.

  11. Evaluation of an effective multifaceted implementation strategy for elective single-embryo transfer after in vitro fertilization

    NARCIS (Netherlands)

    Kreuwel, I.A.M.; Peperstraten, A.M. van; Hulscher, M.E.J.L.; Kremer, J.A.M.; Grol, R.P.T.M.; Nelen, W.L.D.M.; Hermens, R.P.M.G.

    2013-01-01

    STUDY QUESTION: What is the relationship between the rate of elective single-embryo transfer (eSET) and couples' exposure to different elements of a multifaceted implementation strategy? SUMMARY ANSWER: Additional elements in a multifaceted implementation strategy do not result in an increased eSET

  12. Toward a Multifaceted Model of Internet Access for Understanding Digital Divides: An Empirical Investigation

    NARCIS (Netherlands)

    Deursen, van Alexander J.A.M.; Dijk, van Jan A.G.M.

    2015-01-01

    In this investigation, a multifaceted model of Internet appropriation that encompasses four types of access—motivational, material, skills, and usage—is tested with a representative sample of the Dutch population. The analysis indicates that while the digital divide policies' focus has moved to skil

  13. A Multifaceted Approach to Teamwork Assessment in an Undergraduate Business Program

    Science.gov (United States)

    Kemery, Edward R.; Stickney, Lisa T.

    2014-01-01

    We describe a multifaceted, multilevel approach to teamwork learning and assessment. It includes teamwork knowledge, peer and self-appraisal of teamwork behavior, and individual and team performance on objective tests for teaching and assessing teamwork in an undergraduate business program. At the beginning of this semester-long process, students…

  14. A Multifaceted Approach to Teamwork Assessment in an Undergraduate Business Program

    Science.gov (United States)

    Kemery, Edward R.; Stickney, Lisa T.

    2014-01-01

    We describe a multifaceted, multilevel approach to teamwork learning and assessment. It includes teamwork knowledge, peer and self-appraisal of teamwork behavior, and individual and team performance on objective tests for teaching and assessing teamwork in an undergraduate business program. At the beginning of this semester-long process, students…

  15. Toward a Multifaceted Model of Internet Access for Understanding Digital Divides: An Empirical Investigation

    NARCIS (Netherlands)

    van Deursen, Alexander Johannes Aloysius Maria; van Dijk, Johannes A.G.M.

    2015-01-01

    In this investigation, a multifaceted model of Internet appropriation that encompasses four types of access—motivational, material, skills, and usage—is tested with a representative sample of the Dutch population. The analysis indicates that while the digital divide policies' focus has moved to

  16. Results of a Multifaceted Intimate Partner Violence Training Program for Pediatric Residents

    Science.gov (United States)

    McColgan, Maria D.; Cruz, Mario; McKee, Jessica; Dempsey, Sandra H.; Davis, Martha B.; Barry, Patricia; Yoder, Ana Lisa; Giardino, Angelo P.

    2010-01-01

    Objective: To evaluate the efficacy of a multifaceted Intimate Partner Violence (IPV) intervention on knowledge, attitudes, and screening practices of pediatric residents. Methods: The intervention included: an on-site IPV counselor, IPV training for attending physicians, residents and social workers, and screening prompts. Evaluation included…

  17. The primary prevention of asthma in children study: design of a multifaceted prevention program.

    NARCIS (Netherlands)

    Kuiper, S.; Maas, T.; Schayck, C.P. van; Muris, J.W.M.; Schonberger, H.J.; Dompeling, E.C.; Gijsbers, B.; Weel, C. van; Knottnerus, J.A.

    2005-01-01

    The PREVASC study addresses the primary prevention of asthma in infants and small children. The objective of this study is to investigate whether a multifaceted prenatally started intervention strategy in high-risk infants leads to a decrease in the occurrence of (severe) asthma and whether a refine

  18. Defense and the Economy

    Science.gov (United States)

    1993-01-01

    AD A 66 28 o’py 9of 27 copiesII AD-A266 288-co, .o,,,, I IDA PAPER P-28 10I * DEFENSE AND THE ECONOMY David R. Graham An-Jen Tai Barbara A...TYPE AND DATES COVERED January 1993 4. TITLE AND SUBTITLE S. FUNDING NUMBERS Defense and the Economy C-MDA 903 89C 0003i...Fomr 298 (Rev 2-4g) 3Preserked by ANSI Sid, Z39- 2I0 I I I IDA PAPER P-2810() 3 DEFENSE AND THE ECONOMY I I David R. Graham An-Jen Tai Barbara A

  19. Rethinking Defensive Information Warfare

    Science.gov (United States)

    2004-06-01

    electronic warfare, and special information operations. Defensive information operations ensure timely, accurate, and relevant information access...information and information systems. IA, physical security, OPSEC, counter-deception, counter-psyops, CI, EW, and special information operations. Ensure

  20. Surfing China's National Defense

    Institute of Scientific and Technical Information of China (English)

    Ji Guilin

    2010-01-01

    @@ Following the start of its first test run on August 20, 2009, the website www.mod.gov.cn of the Ministry of National Defense (MOD) of the People's Republic of China has logged more than 2 billion hits,from many countries and regions including China, the United States,the United Kingdom, Japan, Australia and Singapore. China National Defense News reporters recently interviewed Ji Guilin, the website's Editor in Chief, on its performance and the feedback of netizens.

  1. 75 FR 76423 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

    Science.gov (United States)

    2010-12-08

    ... of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of... a closed meeting of the Defense Intelligence Agency National Defense Intelligence College Board...

  2. 76 FR 28960 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

    Science.gov (United States)

    2011-05-19

    ... of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of... a closed meeting of the Defense Intelligence Agency National Defense Intelligence College Board...

  3. 76 FR 28757 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-05-18

    ... of the Secretary Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Notice of Availability (NOA) of Revised Defense Logistics Agency Regulation. SUMMARY: The Defense Logistics...

  4. Generic frames and tonality: Mapping a polarizing issue in a multifaceted context

    OpenAIRE

    Gündüz, Ali Asker; Schedler, Kuno; Ciocan, Dumitru

    2016-01-01

    This study explores the feasibility and usefulness of five generic frames (conflict, responsibility, economic consequences, human interest and morality) in analysing framing practices in a multifaceted journalistic field over time. We show that supplementing generic frames through the tonality expressed in news stories enhances analytical quality. Mapping Swiss media outlets by how they frame a highly polarizing policy, we identify different framing practices in covering the issue. Using mult...

  5. ICT and critical thinking : a multifaceted and integrated process in the English Language Learning (ESL)

    OpenAIRE

    Bastos, Ascensão; Ramos, Altina

    2011-01-01

    The increased complexity of our world today calls for learners’ active knowledge construction and collaboration in the learning process, as opposed to traditional approaches based on the assumption that knowledge is transmitted from teacher to student. Accordingly, YouTube, in parallel with Moodle forums, emerge as new learning environments, fostering a multifaceted and integrated process consistent with young digital natives’ profile and the challenges demanded by a knowledge-based society. ...

  6. Predictors of adherence to a multifaceted podiatry intervention for the prevention of falls in older people

    OpenAIRE

    Landorf Karl B; Wee Elin; Fotoohabadi Mohammad R; Spink Martin J; Hill Keith D; Lord Stephen R; Menz Hylton B

    2011-01-01

    Abstract Background Despite emerging evidence that foot problems and inappropriate footwear increase the risk of falls, there is little evidence as to whether foot-related intervention strategies can be successfully implemented. The aim of this study was to evaluate adherence rates, barriers to adherence, and the predictors of adherence to a multifaceted podiatry intervention for the prevention of falls in older people. Methods The intervention group (n = 153, mean age 74.2 years) of a random...

  7. Empirical Evaluation of Fuzzy Synthetic Based Framework for Multifaceted Component Classification and Selection

    Directory of Open Access Journals (Sweden)

    Vinay

    2014-03-01

    Full Text Available Component Based Software Engineering (CBSE provides an approach to develop high quality software system at less cost by using fresh and existing software components. The quality of the software system is based on the quality of individual software component integrated. Application developer wants the good or the fittest component to assemble and improve the quality of the software product. The application developer specifies the criteria and requirements of software systems and uses them in selecting the fit components. Component classification and selection is a practical problem and requires complete and predictable input information. It is missing due to uncertainty in judgment and impression in calculations. Hence, component fitness evaluation, classification and selection are critical, multi-faceted, fuzzy and vague nature problems. There exists many component selection approaches, but theses lack the repeatable, usable, exile, multi-faceted and automated processes for component selection and filtration. These approaches are not fulfilling the objectives of software industry in terms of cost, quality and precision. So, there is need of hour to devise an intelligent approach for multifaceted component fitness evaluation, classification and selection. In this study, fuzzy synthetic based approach is proposed for multi-criteria fitness evaluation, classification and selection of software component. For validation of the proposed framework, fifteen black box components of calculators are used. It helps the application developer in selecting fit or high quality component. The proposed framework reduces the cost and enhances the quality, productivity of software systems.

  8. A multifaceted intervention model can give a lasting improvement of older peoples' nutritional status.

    Science.gov (United States)

    Lorefält, B; Wilhelmsson, S

    2012-04-01

    The purpose of this study was with a multifaceted intervention model improve the nutritional status of elderly people living in residential homes to increase their energy intake and to maintain improvements over time. Three different municipal residential homes in the south-east of Sweden. The study population consisted of 67 elderly people. A within-subjects design was used which means that the participants were their own controls. A multifaceted intervention model was chosen, which included education on both theoretical and practical issues, training and support for staff, and individualized snacks to the residents. Nutritional status was measured by Mini Nutritional Assessment (MNA), the consumption of food was recorded by the staff using a food record method for 3 consecutive days. The length of night-time fasting has been calculated from the food records. Nutritional status improved after 3 months of intervention and was maintained after 9 months. Weight increased during the whole study period. Night-time fasting decreased but not to the recommended level. This study shows that it is possible by a multifaceted intervention model to increase energy intake including expanding snacks and thereby improve and maintain nutritional status over a longer period in the elderly living in residential homes. This result was possible to achieve because staff received education and training in nutritional issues and by provision of support during a period when new routines were introduced.

  9. Defense styles of pedophilic offenders.

    Science.gov (United States)

    Drapeau, Martin; Beretta, Véronique; de Roten, Yves; Koerner, Annett; Despland, Jean-Nicolas

    2008-04-01

    This pilot study investigated the defense styles of pedophile sexual offenders. Interviews with 20 pedophiles and 20 controls were scored using the Defense Mechanisms Rating Scales. Results showed that pedophiles had a significantly lower overall defensive functioning score than the controls. Pedophiles used significantly fewer obsessional-level defenses but more major image-distorting and action-level defenses. Results also suggested differences in the prevalence of individual defenses where pedophiles used more dissociation, displacement, denial, autistic fantasy, splitting of object, projective identification, acting out, and passive aggressive behavior but less intellectualization and rationalization.

  10. The effect of a multifaceted educational intervention on medication preparation and administration errors in neonatal intensive care

    NARCIS (Netherlands)

    Chedoe, Indra; Molendijk, Harry; Hospes, Wobbe; Van den Heuvel, Edwin B.; Taxis, Katja

    2012-01-01

    Objective To examine the effect of a multifaceted educational intervention on the incidence of medication preparation and administration errors in a neonatal intensive care unit (NICU). Design Prospective study with a preintervention and postintervention measurement using direct observation. Setting

  11. Defense Research Enterprise Assessment

    Science.gov (United States)

    2017-01-01

    Please review the report findings and recommendations. I am interested in receiving your feedback for inclusion in programs wherever these...needed culture shift to utilize their existing authorities. Finally, expanded coordination among intermural basic research portfolios across the Labs...research portfolios across the Labs without creating additional administrative burdens is needed. The defense research enterprise should

  12. AFRL Defensive IO Programs

    Science.gov (United States)

    2007-11-02

    Wireless Information Assurance • Steganography • Air Force Enterprise Defense (AFED) 10 Distributed Agents for Information Warfare Operational...information (images, documents, overlays, audio , links, etc.) •multi-level data release to coalition forces; key-based access •covert communication...maximize throughput of communication channels Data Hiding/Embedding Steganography Watermarking Steganalysis 14 Payoffs • Integrates existing

  13. Defense Business Transformation

    Science.gov (United States)

    2009-12-01

    other. SCM and ERP systems both contribute to the overall distribution and coordination of resources. Just as an ERP enhances information flow...inventory management system (Thureen 2008). It combines the Army’s disparate wholesale and retail inventories, into one combined system (Sparacino 2002...Studies.............................................................................. 73 1. Defense Integrated Military Human Resource System

  14. Robust Preallocated Preferential Defense.

    Science.gov (United States)

    1985-08-01

    Frye , W.H. and Ullman, L.L., Methodology for Calculating Minuteman Defense Effectiveness, SRD-EGI4, Stanford Research Institute, October 1973. 4. Hogg...Corporation 1500 Wilson Boulevard Arlington, VA 22209 ATTN: Dr. Tucker Battle Dr. James Skouras Dr. Iram Weinstein Northrop Corporation 8900 E. Washington

  15. Defense Institution Building: An Assessment

    Science.gov (United States)

    2016-01-01

    MoDA and DIILS Support of DIB Activity Objectives . . . . . . . 26 2.8. Overlapping Program Objectives...Wales Initiative Fund–Defense Institution Building (WIF-DIB), the Ministry of Defense Advisors ( MoDA ) program, and the Defense Insti- tute of...other events and activities related to a partner nation’s defense institution capabilities and capacity. One exception is MoDA , where engagements are

  16. Avian host defense peptides.

    Science.gov (United States)

    Cuperus, Tryntsje; Coorens, Maarten; van Dijk, Albert; Haagsman, Henk P

    2013-11-01

    Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of many organisms. It is becoming increasingly clear that in the animal kingdom the functions of HDPs are not confined to direct antimicrobial actions. Research in mammals has indicated that HDPs have many immunomodulatory functions and are also involved in other physiological processes ranging from development to wound healing. During the past five years our knowledge about avian HDPs has increased considerably. This review addresses our current knowledge on the evolution, regulation and biological functions of HDPs of birds.

  17. A Defense Budget Primer

    Science.gov (United States)

    1998-12-09

    budget practices. See Appendix D for the actual timetable of congressional action on the FY1999 budget.65 See James V. Saturno , The Appropriations...details, see James V. Saturno , The Appropriations Process and the Congressional69 Budget Act, CRS Report 97-947. Table 6. Milestone Votes on the Defense...James V. Saturno , The74 Appropriations Process and the Congressional Budget Act, CRS Report 97-947. The Budget Enforcement Act of 1990 and subsequent

  18. Defensive Minefield Planning

    Science.gov (United States)

    1989-06-01

    Minefield Planning by Carlos Vallejo Game Lieutenant, Ecuadorian Navy B. S., Escuela Superior Naval, Ecuador 1980 Submitted in partial fulfillment of...was a superior open-ocean naval force to the North Koreans, defensive minewarfare was able to, at least temporarily, defeat U.S. Navy objectives in...Oswaldo Rosero 1 Unit 8 Coastal Route 1 Monterey, California 93940 77 11. Office of the N’aval Attache 4 Direccion de Educacion 2535 15th. st. N. W

  19. Plant Defense against Insect Herbivores

    Science.gov (United States)

    Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

    2013-01-01

    Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar. Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight, defense compounds. These bioactive specialized plant defense compounds may repel or intoxicate insects, while defense proteins often interfere with their digestion. Volatiles are released upon herbivory to repel herbivores, attract predators or for communication between leaves or plants, and to induce defense responses. Plants also apply morphological features like waxes, trichomes and latices to make the feeding more difficult for the insects. Extrafloral nectar, food bodies and nesting or refuge sites are produced to accommodate and feed the predators of the herbivores. Meanwhile, herbivorous insects have adapted to resist plant defenses, and in some cases even sequester the compounds and reuse them in their own defense. Both plant defense and insect adaptation involve metabolic costs, so most plant-insect interactions reach a stand-off, where both host and herbivore survive although their development is suboptimal. PMID:23681010

  20. A multifaceted model for designing reading development programmes for L2 learners at tertiary level

    Directory of Open Access Journals (Sweden)

    Naomi Boakye

    2012-04-01

    Full Text Available Socio-affective issues are generally acknowledged as important in reading development. However, most intervention programmes focus on cognitive aspects of reading, and do not explicitly accommodate socio-affective factors such as attitude, motivation, interest, and background of students. This paper argues for the inclusion of both cognitive and socio-affective scaffolding in tertiary-level reading development programmes. Based on a number of second language teaching techniques, and grounded in Guthrie and Wigfield’s (2000 engagement model, I propose a multifaceted model on which to map reading instruction/intervention at tertiary level that combines both affective and cognitive factors.

  1. Plant defense against insect herbivores

    DEFF Research Database (Denmark)

    Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

    2013-01-01

    have adapted to resist plant defenses, and in some cases even sequester the compounds and reuse them in their own defense. Both plant defense and insect adaptation involve metabolic costs, so most plant-insect interactions reach a stand-off, where both host and herbivore survive although......Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar....... Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight...

  2. DEFENSE PROGRAMS RISK MANAGEMENT FRAMEWORK

    Directory of Open Access Journals (Sweden)

    Constantin PREDA

    2012-01-01

    Full Text Available For the past years defense programs have faced delays in delivering defense capabilities and budget overruns. Stakeholders are looking for ways to improve program management and the decision making process given the very fluid and uncertain economic and political environment. Consequently, they have increasingly resorted to risk management as the main management tool for achieving defense programs objectives and for delivering the defense capabilities strongly needed for the soldiers on the ground on time and within limited defense budgets. Following a risk management based decision-making approach the stakeholders are expected not only to protect program objectives against a wide range of risks but, at the same time, to take advantage of the opportunities to increase the likelihood of program success. The prerequisite for making risk management the main tool for achieving defense programs objectives is the design and implementation of a strong risk management framework as a foundation providing an efficient and effective application of the best risk management practices. The aim of this paper is to examine the risk management framework for defense programs based on the ISO 31000:2009 standard, best risk management practices and the defense programs’ needs and particularities. For the purposes of this article, the term of defense programs refers to joint defense programs.

  3. Fabrication of multifaceted, micropatterned surfaces and image-guided patterning using laser scanning lithography.

    Science.gov (United States)

    Slater, John H; West, Jennifer L

    2014-01-01

    This protocol describes the implementation of laser scanning lithography (LSL) for the fabrication of multifaceted, patterned surfaces and for image-guided patterning. This photothermal-based patterning technique allows for selective removal of desired regions of an alkanethiol self-assembled monolayer on a metal film through raster scanning a focused 532 nm laser using a commercially available laser scanning confocal microscope. Unlike traditional photolithography methods, this technique does not require the use of a physical master and instead utilizes digital "virtual masks" that can be modified "on the fly" allowing for quick pattern modifications. The process to create multifaceted, micropatterned surfaces, surfaces that display pattern arrays of multiple biomolecules with each molecule confined to its own array, is described in detail. The generation of pattern configurations from user-chosen images, image-guided LSL is also described. This protocol outlines LSL in four basic sections. The first section details substrate preparation and includes cleaning of glass coverslips, metal deposition, and alkanethiol functionalization. The second section describes two ways to define pattern configurations, the first through manual input of pattern coordinates and dimensions using Zeiss AIM software and the second via image-guided pattern generation using a custom-written MATLAB script. The third section describes the details of the patterning procedure and postpatterning functionalization with an alkanethiol, protein, and both, and the fourth section covers cell seeding and culture. We end with a general discussion concerning the pitfalls of LSL and present potential improvements that can be made to the technique.

  4. Followers are not enough: a multifaceted approach to community detection in online social networks.

    Science.gov (United States)

    Darmon, David; Omodei, Elisa; Garland, Joshua

    2015-01-01

    In online social media networks, individuals often have hundreds or even thousands of connections, which link these users not only to friends, associates, and colleagues, but also to news outlets, celebrities, and organizations. In these complex social networks, a 'community' as studied in the social network literature, can have very different meaning depending on the property of the network under study. Taking into account the multifaceted nature of these networks, we claim that community detection in online social networks should also be multifaceted in order to capture all of the different and valuable viewpoints of 'community.' In this paper we focus on three types of communities beyond follower-based structural communities: activity-based, topic-based, and interaction-based. We analyze a Twitter dataset using three different weightings of the structural network meant to highlight these three community types, and then infer the communities associated with these weightings. We show that interesting insights can be obtained about the complex community structure present in social networks by studying when and how these four community types give rise to similar as well as completely distinct community structure.

  5. Measuring teacher dispositions using the DAATS battery: a multifaceted Rasch analysis of rater effect.

    Science.gov (United States)

    Lang, W Steve; Wilkerson, Judy R; Rea, Dorothy C; Quinn, David; Batchelder, Heather L; Englehart, Dierdre S; Jennings, Kelly J

    2014-01-01

    The purpose of this study was to examine the extent to which raters' subjectivity impacts measures of teacher dispositions using the Dispositions Assessments Aligned with Teacher Standards (DAATS) battery. This is an important component of the collection of evidence of validity and reliability of inferences made using the scale. It also provides needed support for the use of subjective affective measures in teacher training and other professional preparation programs, since these measures are often feared to be unreliable because of rater effect. It demonstrates the advantages of using the Multi-Faceted Rasch Model as a better alternative to the typical methods used in preparation programs, such as Cohen's Kappa. DAATS instruments require subjective scoring using a six-point rating scale derived from the affective taxonomy as defined by Krathwohl, Bloom, and Masia (1956). Rater effect is a serious challenge and can worsen or drift over time. Errors in rater judgment can impact the accuracy of ratings, and these effects are common, but can be lessened through training of raters and monitoring of their efforts. This effort uses the multifaceted Rasch measurement models (MFRM) to detect and understand the nature of these effects.

  6. A practical scale for Multi-Faceted Organizational Health Climate Assessment.

    Science.gov (United States)

    Zweber, Zandra M; Henning, Robert A; Magley, Vicki J

    2016-04-01

    The current study sought to develop a practical scale to measure 3 facets of workplace health climate from the employee perspective as an important component of a healthy organization. The goal was to create a short, usable yet comprehensive scale that organizations and occupational health professionals could use to determine if workplace health interventions were needed. The proposed Multi-faceted Organizational Health Climate Assessment (MOHCA) scale assesses facets that correspond to 3 organizational levels: (a) workgroup, (b) supervisor, and (c) organization. Ten items were developed and tested on 2 distinct samples, 1 cross-organization and 1 within-organization. Exploratory and confirmatory factor analyses yielded a 9-item, hierarchical 3-factor structure. Tests confirmed MOHCA has convergent validity with related constructs, such as perceived organizational support and supervisor support, as well as discriminant validity with safety climate. Lastly, criterion-related validity was found between MOHCA and health-related outcomes. The multi-faceted nature of MOHCA provides a scale that has face validity and can be easily translated into practice, offering a means for diagnosing the shortcomings of an organization or workgroup's health climate to better plan health and well-being interventions.

  7. Multifaceted and route-controlled "click" reactions based on vapor-deposited coatings.

    Science.gov (United States)

    Sun, Ting-Pi; Tai, Ching-Heng; Wu, Jyun-Ting; Wu, Chih-Yu; Liang, Wei-Chieh; Chen, Hsien-Yeh

    2016-02-01

    "Click" reactions provide precise and reliable chemical transformations for the preparation of functional architectures for biomaterials and biointerfaces. The emergence of a multiple-click reaction strategy has paved the way for a multifunctional microenvironment with orthogonality and precise multitasking that mimics nature. We demonstrate a multifaceted and route-controlled click interface using vapor-deposited functionalized poly-para-xylylenes. Distinctly clickable moieties of ethynyl and maleimide were introduced into poly-para-xylylenes in one step via a chemical vapor deposition (CVD) copolymerization process. The advanced interface coating allows for a double-click route with concurrent copper(i)-catalyzed Huisgen 1,3-dipolar cycloaddition (CuAAC) and the thiol-maleimide click reaction. Additionally, double-click reactions can also be performed in a cascade manner by controlling the initiation route to enable the CuAAC and/or thiol-yne reaction using a mono-functional alkyne-functionalized poly-para-xylylene. The use of multifaceted coatings to create straightforward and orthogonal interface properties with respect to protein adsorption and cell attachment is demonstrated and characterized.

  8. Synthetic Plant Defense Elicitors

    Directory of Open Access Journals (Sweden)

    Yasemin eBektas

    2015-01-01

    Full Text Available To defend themselves against invading pathogens plants utilize a complex regulatory network that coordinates extensive transcriptional and metabolic reprogramming. Although many of the key players of this immunity-associated network are known, the details of its topology and dynamics are still poorly understood. As an alternative to forward and reverse genetic studies, chemical genetics-related approaches based on bioactive small molecules have gained substantial popularity in the analysis of biological pathways and networks. Use of such molecular probes can allow researchers to access biological space that was previously inaccessible to genetic analyses due to gene redundancy or lethality of mutations. Synthetic elicitors are small drug like molecules that induce plant defense responses, but are distinct from known natural elicitors of plant immunity. While the discovery of the some synthetic elicitors had already been reported in the 1970s, recent breakthroughs in combinatorial chemical synthesis now allow for inexpensive high-throughput screens for bioactive plant defense-inducing compounds. Along with powerful reverse genetics tools and resources available for model plants and crop systems, comprehensive collections of new synthetic elicitors will likely allow plant scientists to study the intricacies of plant defense signaling pathways and networks in an unparalleled fashion. As synthetic elicitors can protect crops from diseases, without the need to be directly toxic for pathogenic organisms, they may also serve as promising alternatives to conventional biocidal pesticides, which often are harmful for the environment, farmers and consumers. Here we are discussing various types of synthetic elicitors that have been used for studies on the plant immune system, their modes-of-action as well as their application in crop protection.

  9. Nanomaterials for Defense Applications

    Science.gov (United States)

    Turaga, Uday; Singh, Vinitkumar; Lalagiri, Muralidhar; Kiekens, Paul; Ramkumar, Seshadri S.

    Nanotechnology has found a number of applications in electronics and healthcare. Within the textile field, applications of nanotechnology have been limited to filters, protective liners for chemical and biological clothing and nanocoatings. This chapter presents an overview of the applications of nanomaterials such as nanofibers and nanoparticles that are of use to military and industrial sectors. An effort has been made to categorize nanofibers based on the method of production. This chapter particularly focuses on a few latest developments that have taken place with regard to the application of nanomaterials such as metal oxides in the defense arena.

  10. Phenomenon of Psychological Defense

    Directory of Open Access Journals (Sweden)

    Elena T. Sokolova

    2011-01-01

    Full Text Available The author discusses the controversial issues of formation and functioning of psy¬chological defense mechanisms in ontogenesis and in personality disorders as they are represented in classical and contemporary psychoanalysis, in cognitivism and communication theory. The paper emphasizes the role of cognitive organi¬zation (style, sign-symbolic mediation, representative system of object relations and attachments in individual typological variability of the level organization of ciency of personal and social adaptation, in maturity and mental health of personality

  11. Special feature: a multifacet circumplex model of personality as a basis for the description and therapy of personality disorders.

    Science.gov (United States)

    Becker, P

    1998-01-01

    A new circumplex model of personality, based upon two higher order personality factors, mental health and behavior control, is presented. This eight-octant model, which also includes the two multifacet dimensions of "social adaptation vs. unrestraint" and "self-actualization vs. inhibition," should not be confused with two other well-known circumplex models: the interpersonal model and the Eysenck model. Mental health, a multifacet construct, is defined as the ability to cope with external and internal demands. Behavior control, also a multifacet construct, is characterized by self-control (norm-, future-, work-, and reason-orientation; orderliness) vs. spontaneity (hedonism, excitement seeking, feeling orientation, liveliness). The theoretical background and facets of these constructs are presented. The model is useful for the description of personality disorders, and etiological hypotheses are formulated from the combination of this model with a circumplex model of interpersonal behavior. Finally, some therapeutic implications of the model are discussed.

  12. Defensive engagement and perceptual enhancement

    OpenAIRE

    Keil, Andreas; Bradley, Margaret M; Ihssen, Niklas; Heim, Sabine; Vila, Jaime; Guerra, Pedro; Lang, Peter J.

    2010-01-01

    We tested whether visual cortical sensitivity to external cues in the context of an acute defensive reaction is heightened or attenuated. A strong cardiac defense (fear) response was elicited by presenting an abrupt, loud acoustic stimulus following a 10-minute period of quiescence. Electrocortical responses to aversive and neutral pictures following defensive stimulus onset were measured using dense-array EEG. Pictures were flickered at 12.5 Hz to evoke steady-state visual evoked potentials ...

  13. Ballistic Missile Defense System (BMDS)

    Science.gov (United States)

    2015-12-01

    Estimate RDT&E - Research , Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be Determined TY - Then...all ranges and in all phases of flight. Following guidance from the President, the Secretary of Defense approved the Ballistic Missile Defense (BMD...based Midcourse Defense (GMD) system to enhance our capability against Intercontinental Ballistic Missiles. We are currently sustaining 30

  14. The evaluation of a multifaceted intervention to promote "speaking up" and strengthen interprofessional teamwork climate perceptions.

    Science.gov (United States)

    Ginsburg, Liane; Bain, Lorna

    2017-03-01

    Communication failure is a leading cause of error and is often due to inhibition of individuals to speak up in interprofessional healthcare environments. The present study sought to evaluate the impact of a multifaceted intervention designed to promote speaking up on teamwork climate in one clinical department of a large community hospital based in Canada. The multifaceted intervention included a role-playing simulation workshop, teamwork climate data feedback and facilitated discussion with the interprofessional team (discussion briefings), and other department-led initiatives to promote trust, teamwork, and speaking up among interprofessional team members. A quasi-experiment (pretest-posttest control group design, using two posttests several months apart) was used to evaluate the impact of the complete intervention on individual teamwork climate perceptions. The intervention was implemented with an intact interprofessional team (the Emergency Department-ED) in 2014. The intensive care unit (ICU) was used as the control unit. Survey response rates were the highest at time 1 (83/102 = 81% for the ED and 29/31 = 94% for the ICU) and the lowest at time 3 (38/105 = 36% for the ED and 14/30 = 47% for the ICU). The results obtained from paired and unpaired analyses suggest that this type of multifaceted approach can improve staff perceptions of teamwork climate. The teamwork climate score in the ED was significantly higher at follow-up (Mt2 = 3.42, SD = 0.66) compared to baseline (Mt1 = 3.13, SD = 0.72), (F(1, 34) = 12.2, p = .001, eta(2)p = .263), while baseline and follow-up scores were not significantly different between baseline and follow-up for the ICU group (Mt1 = 4.12, SD = 0.60; Mt2 = 4.15, SD = 0.56; F(1, 34) = 0.06, p = .806, eta(2)p = .002). Sustaining high levels of participation in interprofessional initiatives and engaging physicians remain challenging when interventions are used in context. Improving team

  15. Multifaceted nutritional intervention among nursing-home residents has a positive influence on nutrition and function

    DEFF Research Database (Denmark)

    Beck, Anne Marie; Damkjær, Karin; Beyer, Nina

    2008-01-01

    intervention study with nutrition (chocolate and homemade oral supplements), group exercise twice a week (45-60 min, moderate intensity), and oral care intervention one to two times a week, with the aim of improving nutritional status and function in elderly nursing-home residents. A follow-up visit was made 4......Objective: We tested the hypothesis that a multifaceted 11-wk intervention comprising nutrition, group exercise, and oral care would have a significant influence on nutrition and function in elderly ( >= 65 y) nursing-home residents. Methods: The study was an 11-wk randomized controlled....... Six of these dropped out during the 11 wk. At the 4-mo follow-up there were 15 deaths in the intervention group and 8 in the control group. The nutrition and exercise were well tolerated. After 11wk the change in percentage of weight (P = 0.005), percentage of body mass index (P = 0.003). energy...

  16. Combining theories to reach multi-faceted insights into learning opportunities in doctoral supervision

    DEFF Research Database (Denmark)

    Kobayashi, Sofie; Rump, Camilla Østerberg

    in science learning; conceptual change, socio-constructivism and post-structuralism. In the present study we employ variation theory (Marton & Tsui, 2004) to study the individual acquisition perspective, what Zembylas terms conceptual change. As for the post-structural perspective we employ positioning......The aim of this paper is to illustrate how theories can be combined to explore opportunities for learning in doctoral supervision. While our earlier research into learning dynamics in doctoral supervision in life science research (Kobayashi, 2014) has focused on illustrating learning opportunities......-another when intertwining the analyses to get a multi-faceted insight into the phenomenon of learning to be a life science researcher. The data was derived from four observations of supervision of doctoral students in life science, each with a doctoral student and two supervisors. The storylines hypothesized...

  17. Improving surgical site infection prevention practices through a multifaceted educational intervention.

    LENUS (Irish Health Repository)

    Owens, P

    2015-03-01

    As part of the National Clinical Programme on healthcare-associated infection prevention, a Royal College of Surgeons in Ireland (RCSI) and Royal College of Physicians of Ireland (RCPI) working group developed a quality improvement tool for prevention of surgical site infection (SS). We aimed to validate the effectiveness of an educational campaign, which utilises this quality improvement tool to prevent SSI in a tertiary hospital. Prior to the SSI educational campaign, surgical patients were prospectively audited and details of antibiotic administration recorded. Prophylactic antibiotic administration recommendations were delivered via poster and educational presentations. Post-intervention, the audit was repeated. 50 patients were audited pre-intervention, 45 post-intervention. Post-intervention, prophylaxis within 60 minutes prior to incision increased from 54% to 68% (p = 0.266). Appropriate postoperative prescribing improved from 71% to 92% (p = 0.075). A multifaceted educational program may be effective in changing SSI prevention practices.

  18. A multifaceted implementation strategy versus passive implementation of low back pain guidelines in general practice

    DEFF Research Database (Denmark)

    Riis, Allan; Jensen, Cathrine Elgaard; Bro, Flemming

    2016-01-01

    primary care to secondary care. The primary aim of this project was to reduce secondary care referral within 12 weeks by a multifaceted implementation strategy (MuIS). METHODS: In a cluster randomised design, 189 general practices from the North Denmark Region were invited to participate. Practices were....... In an intention-to-treat analysis, the primary and secondary outcomes pertained to the patient, and a cost-effectiveness analysis was performed from a healthcare sector perspective. Patients and the assessment of outcomes were blinded. Practices and caregivers delivering the interventions were not blinded....... RESULTS: Between January 2013 and July 2014, 60 practices were included, of which 54 practices (28 MuIS, 26 PaIS) included 1101 patients (539 MuIS, 562 PaIS). Follow-up data for the primary outcome were available on 100 % of these patients. Twenty-seven patients (5.0 %) in the MuIS group were referred...

  19. A person-centered approach to the multifaceted nature of young adult sexual behavior.

    Science.gov (United States)

    McGuire, Jenifer K; Barber, Bonnie L

    2010-07-01

    Young adult sexual relationships were examined using a multifaceted, person-centered approach with data from Wave 7 (aged 20-21; N = 1,126) of the Michigan Study of Adolescent Life Transitions. The study utilized hierarchical cluster analyses based on the following measured variables: frequency of sex, importance of regularly having sex, satisfaction with sex life, experience of coercion for sex, and sexual risk reduction. Five distinct clusters emerged for females (Satisfied, Moderate, Active Unprotected, Pressured, and Inactive) and represented patterns such as more partners paired with less risk reduction (Active Unprotected), high satisfaction paired with frequent sex and high-risk reduction (Satisfied), or higher levels of coercion paired with low satisfaction and low-risk reduction (Pressured). Similar clusters emerged for males, with one additional cluster: the Dissatisfied cluster. Clusters differed with respect to relationship status, marital status, and psychological well-being (both males and females) and parental divorce, living situation, and sexual orientation (females only).

  20. Outcomes of a Multi-faceted Educational Intervention to Increase Student Scholarship.

    Science.gov (United States)

    Cooley, Janet; Nelson, Melissa; Slack, Marion; Warholak, Terri

    2015-08-25

    Objective. To increase the percentage of state, national, or international student presentations and publications. Design. A multi-faceted intervention to increase student scholarly output was developed that included: (1) a 120-minute lecture on publication of quality improvement or independent study research findings; (2) abstract workshops; (3) poster workshops; and (4) a reminder at an advanced pharmacy practice experience (APPE) meeting encouraging students to publish or present posters. The intervention effect was measured as the percent of students who presented at meetings and the number of student projects published. Assessment. A significant increase occurred in the percent of students who presented posters or published manuscripts after the intervention (64% vs 81%). Total student productivity increased from 84 to 147 posters, publications, and presentations. The number of projects presented or published increased from 50 to 77 in one year. Conclusion. This high-impact, low-cost intervention increased scholarly output and may help students stand out in a competitive job market.

  1. Help Wanted: American Drone Program Needs Multifaceted Support to be Effective

    Directory of Open Access Journals (Sweden)

    S. Hall

    2014-12-01

    Full Text Available The U.S. drone program in Pakistan faces strong resistance in Pakistan. Because the program solely seeks to eliminate terrorist groups and leaders through bombing campaigns, with no built in social support, the local population’s anti-American sentiment has reached the highest level in history. This angry mood against U.S. drone programs is spreading throughout the Islamic world. To counter this anti-American sentiment, and increase the drone program’s effectiveness, the U.S. must invest in multifaceted, socio-economic support efforts to educate the population and rebuild the gratuity, trust, and commitment of Pakistan’s people to the “War on Terror.”

  2. A Multi-facetted Visual Analytics Tool for Exploratory Analysis of Human Brain and Function Datasets.

    Science.gov (United States)

    Angulo, Diego A; Schneider, Cyril; Oliver, James H; Charpak, Nathalie; Hernandez, Jose T

    2016-01-01

    Brain research typically requires large amounts of data from different sources, and often of different nature. The use of different software tools adapted to the nature of each data source can make research work cumbersome and time consuming. It follows that data is not often used to its fullest potential thus limiting exploratory analysis. This paper presents an ancillary software tool called BRAVIZ that integrates interactive visualization with real-time statistical analyses, facilitating access to multi-facetted neuroscience data and automating many cumbersome and error-prone tasks required to explore such data. Rather than relying on abstract numerical indicators, BRAVIZ emphasizes brain images as the main object of the analysis process of individuals or groups. BRAVIZ facilitates exploration of trends or relationships to gain an integrated view of the phenomena studied, thus motivating discovery of new hypotheses. A case study is presented that incorporates brain structure and function outcomes together with different types of clinical data.

  3. Examining Motivation in Online Distance Learning Environments: Complex, Multifaceted, and Situation-Dependent

    Directory of Open Access Journals (Sweden)

    Maggie Hartnett

    2011-10-01

    Full Text Available Existing research into motivation in online environments has tended to use one of two approaches. The first adopts a trait-like model that views motivation as a relatively stable, personal characteristic of the learner. Research from this perspective has contributed to the notion that online learners are, on the whole, intrinsically motivated. The alternative view concentrates on the design of online learning environments to encourage optimal learner motivation. Neither approach acknowledges a contemporary view of motivation that emphasises the situated, mutually constitutive relationship of the learner and the learning environment. Using self-determination theory (SDT as a framework, this paper explores the motivation to learn of preservice teachers in two online distance-learning contexts. In this study, learners were found to be not primarily intrinsically motivated. Instead, student motivation was found to be complex, multifaceted, and sensitive to situational conditions.

  4. Multifaceted Material Substitution: The Case of NdFeB Magnets, 2010-2015

    Science.gov (United States)

    Smith, Braeton J.; Eggert, Roderick G.

    2016-07-01

    Substitution is an important response for material users when faced with disruption to the availability or price of an essential material. In economic terms, substitution refers to the ability of firms to alter their patterns of material use in response to exogenous market shocks. Substitution comes in different forms which vary from situation to situation. This paper uses expert opinion to identify the specific forms of substitution that occurred in permanent magnets, specifically neodymium-iron-boron magnets, following the significant increase in rare earth prices in 2010-2011. The paper provides a framework for understanding the multifaceted nature of substitution and assesses the relative importance of five different types of substitution. Technology-for-element, grade-for-grade, and system-for-system substitution appear to have been more important than element-for-element and magnet-for-magnet substitution. Cost pass-through and absorption were also important responses.

  5. Cybersecurity vulnerabilities in medical devices: a complex environment and multifaceted problem.

    Science.gov (United States)

    Williams, Patricia Ah; Woodward, Andrew J

    2015-01-01

    The increased connectivity to existing computer networks has exposed medical devices to cybersecurity vulnerabilities from which they were previously shielded. For the prevention of cybersecurity incidents, it is important to recognize the complexity of the operational environment as well as to catalog the technical vulnerabilities. Cybersecurity protection is not just a technical issue; it is a richer and more intricate problem to solve. A review of the factors that contribute to such a potentially insecure environment, together with the identification of the vulnerabilities, is important for understanding why these vulnerabilities persist and what the solution space should look like. This multifaceted problem must be viewed from a systemic perspective if adequate protection is to be put in place and patient safety concerns addressed. This requires technical controls, governance, resilience measures, consolidated reporting, context expertise, regulation, and standards. It is evident that a coordinated, proactive approach to address this complex challenge is essential. In the interim, patient safety is under threat.

  6. Multifaceted nutritional intervention among nursing-home residents has a positive influence on nutrition and function.

    Science.gov (United States)

    Beck, Anne Marie; Damkjaer, Karin; Beyer, Nina

    2008-01-01

    We tested the hypothesis that a multifaceted 11-wk intervention comprising nutrition, group exercise, and oral care would have a significant influence on nutrition and function in elderly (>or=65 y) nursing-home residents. The study was an 11-wk randomized controlled intervention study with nutrition (chocolate and homemade oral supplements), group exercise twice a week (45-60 min, moderate intensity), and oral care intervention one to two times a week, with the aim of improving nutritional status and function in elderly nursing-home residents. A follow-up visit was made 4 mo after the end of the intervention. Assessments were weight, body mass index, dietary intake, handgrip strength, Senior Fitness Test, Berg's Balance Scale, and the prevalence of plaque. A total of 121 subjects (61%) accepted the invitation and 62 were randomized to the intervention group. Six of these dropped out during the 11 wk. At the 4-mo follow-up there were 15 deaths in the intervention group and 8 in the control group. The nutrition and exercise were well tolerated. After 11 wk the change in percentage of weight (P = 0.005), percentage of body mass index (P = 0.003), energy intake (P = 0.084), protein intake (P = 0.012), and Berg's Balance Scale (P = 0.004) was higher in the intervention group than in the control group. In addition, the percentage of subjects whose functional tests improved was higher in the intervention group. Both groups lost the same percentage of weight after the intervention (P = 0.908). The total percentage of weight loss from baseline to follow-up was higher in the control group (P = 0.019). Oral care was not well accepted and the prevalence of plaque did not change. It is possible to improve nutrition and function in elderly nursing-home residents by means of a multifaceted intervention consisting of chocolate, homemade supplements, group exercise, and oral care.

  7. Clean Hands for Life: results of a large, multicentre, multifaceted, social marketing hand-hygiene campaign.

    Science.gov (United States)

    Forrester, L A; Bryce, E A; Mediaa, A K

    2010-03-01

    A year-long multifaceted hand-hygiene campaign entitled Clean Hands for Life targeting individual, environmental and organisational factors that influence healthcare worker (HCW) hand-hygiene behaviour was implemented in 36 acute and long-term care facilities in Vancouver Coastal Health region. The campaign involved rotation of ten novel posters, two poster contests, and distribution of multiple promotional items. A social marketing approach was used to implement and monitor the effectiveness of the campaign. Evaluation included quality assurance surveys, staff surveys (baseline, mid- and post-campaign), and focus groups. A total of 141 poster contest submissions was received, 5452 staff surveys completed and 14 focus groups conducted. Overall knowledge of the importance of hand-hygiene and intention to clean hands was high at baseline. No significant differences were observed when mid- and post-campaign scores were compared to baseline. The majority (89.5%) of HCWs reported that they preferred soap and water over alcohol hand gel. A significant increase in the self-reported use of hand-hygiene products was observed particularly among HCWs not providing direct patient care. Barriers to hand-hygiene included inappropriate placement of sinks, traffic flow issues, inadequately stocked washrooms, workload and time constraints. Organisational support was visible throughout the campaign. The results showed that social marketing is an effective approach in engaging HCWs. Hand-hygiene campaigns that focus almost exclusively on increasing awareness among HCWs may not be as successful as multifaceted campaigns or campaigns that target identified barriers to hand-hygiene. Copyright 2009 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

  8. European Missile Defense and Russia

    Science.gov (United States)

    2014-07-01

    most senior level—the only one that matters in Russian decisionmaking cul - ture—is also of significance today and will also be re- ferred to later in... org /missile-defense/us-ballistic-missile-defense/p30607. 9. Email exchange with author, July 2013. 10. “Safeguard,” Washington, DC: Federation of Ameri

  9. Plant defense against insect herbivores

    DEFF Research Database (Denmark)

    Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

    2013-01-01

    defense responses. Plants also apply morphological features like waxes, trichomes and latices to make the feeding more difficult for the insects. Extrafloral nectar, food bodies and nesting or refuge sites are produced to accommodate and feed the predators of the herbivores. Meanwhile, herbivorous insects......Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar....... Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight...

  10. Cost-Effectiveness of the Diabetes Care Protocol, a Multifaceted Computerized Decision Support Diabetes Management Intervention That Reduces Cardiovascular Risk

    NARCIS (Netherlands)

    Cleveringa, Frits G. W.; Welsing, Paco M. J.; van den Donk, Maureen; Gorter, Kees J.; Niessen, Louis W.; Rutten, Guy E. H. M.; Redekop, William K.

    2010-01-01

    OBJECTIVE - The Diabetes Care Protocol (DCP), a multifaceted Computerized decision support diabetes management intervention, reduces cardiovascular risk Of type 2 diabetic patients. We performed a cost-effectiveness analysis of DCP from a Dutch health care perspective. RESEARCH DESIGN AND METHODS -

  11. Cost-effectiveness of the diabetes care protocol, a multifaceted computerized decision support diabetes management intervention that reduces cardiovascular risk

    NARCIS (Netherlands)

    F.G.W. Cleveringa (Frits G.); P.M.J. Welsing (Paco); M. van den Donk (Maureen); K.J. Gorter; L.W. Niessen (Louis Wilhelmus); G.E.H.M. Rutten (Guy); W.K. Redekop (Ken)

    2010-01-01

    textabstractOBJECTIVE- The Diabetes Care Protocol (DCP), a multifaceted computerized decision support diabetes management intervention, reduces cardiovascular risk of type 2 diabetic patients. We performed a cost-effectiveness analysis of DCP from a Dutch health care perspective. RESEARCH DESIGN AND

  12. Unpacking the Complex and Multifaceted Nature of Parental Influences on Southeast Asian American College Students' Educational Trajectories

    Science.gov (United States)

    Museus, Samuel D.

    2013-01-01

    This article reports on a study that examined the ways in which parents influence the educational trajectories of Southeast Asian American (SEAA) undergraduates at four-year institutions. Individual, face-to-face interviews with 34 SEAAs were conducted and analyzed. Findings illustrate the complex and multifaceted ways that parental influences…

  13. Evaluation of a multifaceted intervention to limit excessive antipsychotic co-prescribing in schizophrenia out-patients

    DEFF Research Database (Denmark)

    Baandrup, Lone; Allerup, Peter; Lublin, H;

    2010-01-01

    OBJECTIVE: To evaluate the effect of a multifaceted educational intervention on the frequency of antipsychotic co-prescribing in adult schizophrenia out-patients. METHOD: Controlled quasi-experimental study performed in two Danish municipalities matched for baseline prevalence of antipsychotic...

  14. The Structural Validity of the Perceived Traits of the "Ideal Student" Multi-Faceted Theory among Education Students

    Science.gov (United States)

    Maslovaty, Nava; Cohen, Arie; Furman, Sari

    2008-01-01

    The article presents a multi-faceted theory of "ideal high school student" traits. The trait system, as defined by several theories, is a translation of the teachers' belief system into educational objectives. The study focused on Bloom's taxonomies and the structural validity of its principles, using Similarity Structure Analysis. Aware of the…

  15. A multifaceted intervention: no increase in general practitioners' competence to diagnose skin cancer (minSKIN) - randomized controlled trial

    NARCIS (Netherlands)

    Badertscher, N.; Tandjung, R.; Senn, O.; Kofmehl, R.; Held, U.; Rosemann, T.; Hofbauer, G.F.; Wensing, M.; Rossi, P.O.; Braun, R.P.

    2015-01-01

    BACKGROUND: General practitioners (GPs) play crucial roles in early detection of skin cancer. A pilot-study found a positive short-term effect of a 1-day dermatologic education programme on GPs' diagnostic competence. OBJECTIVE: To determine effects of a multifaceted intervention, including

  16. Defense Strategies Against Modern Botnets

    CERN Document Server

    Stankovic, Srdjan

    2009-01-01

    Botnets are networks of compromised computers with malicious code which are remotely controlled and which are used for starting distributed denial of service (DDoS) attacks, sending enormous number of e-mails (SPAM) and other sorts of attacks. Defense against modern Botnets is a real challenge. This paper offers several strategies for defense against Botnets with a list and description of measures and activities which should be carried out in order to establish successful defense. The paper also offers parallel preview of the strategies with their advantages and disadvantages considered in accordance with various criteria.

  17. Quadrennial Defense Review and Ballistic Missile Defense Review

    Science.gov (United States)

    2010-03-11

    global defense posture 3 BMDR Highlights • Outlines a strategy and policy framework to – Defend the homeland against limited ballistic missile attack...abroad – Collaborate closely with allies and partners – Pursue a cooperative and tailored global defense posture – Strengthen US civilian capacity...reviews in 2010 – QDR and BMDR released February 1, 2010 – Nuclear Posture Review to be released this spring – Space Posture Review, with Director of

  18. Molecular strategies of plant defense and insect counter-defense

    Institute of Scientific and Technical Information of China (English)

    KEYANZHU-SALZMAN; JIAN-LONGBI; TONG-XIANLIU

    2005-01-01

    The prediction of human population growth worldwide indicates there will be a need to substantially increase food production in order to meet the demand on food supply.This can be achieved in part by the effective management of insect pests. Since plants have co-evolved with herbivorous insects for millions of years, they have developed an array of defense genes to protect themselves against a wide variety of chewing and sucking insects.Using these naturally-occurring genes via genetic engineering represents an environmentally friendly insect pest-control measure. Insects, however, have been actively evolving adaptive mechanisms to evade natural plant defenses. Such evolved adaptability undoubtedly has helped insects during the last century to rapidly overcome a great many humanimposed management practices and agents, including chemical insecticides and genetically engineered plants. Thus, better understanding of the molecular and genetic basis of plant defense and insect counter-defense mechanisms is imperative, not only from a basic science perspective, but also for biotechnology-based pest control practice. In this review, we emphasize the recent advance and understanding of molecular strategies of attack-counterattack and defense-counter-defense between plants and their herbivores.

  19. Defense Meteorological Satellite Program (DMSP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Defense Meteorological Satellite Program (DMSP) satellites collect visible and infrared cloud imagery as well as monitoring the atmospheric, oceanographic,...

  20. Defense Spending and the Economy

    Science.gov (United States)

    1983-12-07

    the first resolution. Our forecast projects continued growth in the economy and moderate inflation for one or possibly two years, despite federal...than provided in the resolution. Additional emphasis on defense would, of course, promote defense-intensive sectors of the economy at the expense of...others, but CBO believes the economy could accommodate such shifts without significant adverse effects on macroeconomic variables such as employment

  1. Theater Missile Defense Integration Issues

    Science.gov (United States)

    1993-06-01

    high endoatmospheric defense interceptor (HEDI) proposed t earlier. EADTB. Extended Air Defense Test Bed. A computer-based analysis center for...for attacking deeper elements of an aggressors’s ground forces. Known in NATO as Follow-on Force Attack ( FOFA ). JSTARS. Joint surveillance target...AFIA/INKS ATTN. INKS AFIS/INT ATTN: INT AIR hORCE CTR FOR STUDIES & ANALYSIS ATTN: AFSAA/SAKI 9 Dist-1 w^mmmm mmmm^-mmmemH

  2. A multifaceted approach to decrease inappropriate antibiotic use in a pediatric outpatient clinic

    Science.gov (United States)

    Al-Tawfiq, Jaffar A.; Alawami, Amel H.

    2017-01-01

    BACKGROUND: Inappropriate use of antimicrobial agents is the major cause for the development of resistance. Thus, it is important to include outpatient clinics in the development of antibiotic stewardship program. METHODS: We report a multifaceted approach to decrease inappropriate antibiotic use in upper respiratory tract infections (URTIs) in an outpatient pediatric clinic. The interventions included educational grand round, academic detailing, and prospective audit and feedback and peer comparison. RESULTS: During the study period, a total of 3677 outpatient clinic visits for URTIs were evaluated. Of all the included patients, 12% were 5 years of age. Of the total patients, 684 (17.6%) received appropriate antibiotics, 2812 (76.4%) appropriately did not receive antibiotics, and 217 (6%) inappropriately received antibiotics. The monthly rate of prescription of inappropriate antibiotics significantly decreased from 12.3% at the beginning of the study to 3.8% at the end of the study (P < 0.0001). Antibiotic prescription among those who had rapid streptococcal antigen test (RSAT) was 40% compared with 78% among those who did not have RSAT (P < 0.0001). CONCLUSIONS: The combination of education and academic detailing is important to improve antibiotic use. PMID:28197223

  3. A Multifaceted FISH Approach to Study Endogenous RNAs and DNAs within Native Nuclear and Cell Structure

    Science.gov (United States)

    Byron, Meg; Hall, Lisa L.; Lawrence, Jeanne B.

    2013-01-01

    Fluorescence in situ hybridization (FISH) is not a singular technique, but a battery of powerful and versatile tools to examine the distribution of endogenous genes and RNAs in precise context with each other and in relation to specific proteins or cell structures. This unit offers the details of highly sensitive and successful protocols that were initially developed largely in our lab and honed over a number of years. Our emphasis is on analysis of nuclear RNAs and DNA to address specific biological questions about nuclear structure, pre-mRNA metabolism or the role of non-coding RNAs, although cytoplasmic RNA detection is also provided and generally discussed. Multi-faceted molecular cytological approaches bring precise resolution and sensitive multi-color detection to illuminate the organization and functional roles of endogenous genes and their RNAs within the native structure of fixed cells. Solutions to several common technical pitfalls are discussed, as are cautions regarding the judicious use of digital imaging and the rigors of analyzing and interpreting complex molecular cytological results. PMID:23315927

  4. Developing the OORCC: A Multifaceted Astronomical Research and Outreach Facility at the University of Oregon

    Science.gov (United States)

    Kwan, Teiler J.; Bullis, Jeremy; Gustafsson, Annika; Fisher, Robert Scott

    2015-01-01

    The University of Oregon (UO) owns and operates Pine Mountain Observatory (PMO), located in central Oregon on the summit of Pine Mountain at an elevation of 1980 meters. PMO consists of four telescopes ranging in size from 0.35 - 0.8 meters. The Oregon Observatory Remote Control Center (OORCC) is a remote-observing center within the Department of Physics on the UO campus (~140 miles from the observatory) that has a direct connection to PMO through a dedicated fiber-optic cable. With this facility, we will enable UO undergraduate student researchers, UO faculty, and the non-scientific community to fully control and operate a newly installed robotic telescope on the summit of Pine Mountain from Eugene, or any other authorized site in Oregon. In addition to providing undergraduates with instrumentation and engineering experience, we will implement research by photometrically monitoring bright and variable astronomical sources including main belt comets, Herbig Ae/Be stars, and active galactic nuclei in extragalactic systems. The primary objective with the OORCC is to manage a multifaceted astronomy and astrophysics research facility, extending as a state-wide resource for K-12 STEM activities and public outreach programs. With the OORCC, we intend to bring unique and enriching astronomy exposure to many different groups of people throughout the state of Oregon.

  5. Early pregnancy ultrasound and management – effect of a multifaceted training on physician knowledge

    LENUS (Irish Health Repository)

    O’Leary, B

    2016-02-01

    Vaginal bleeding is a common event in early pregnancy, with 20-40% of pregnancies affected. Prompt diagnosis and management of bleeding is important, both to reduce morbidity and to avoid excessive emotional distress. This was a prospective study of an educational programme aimed at Obstetrics and Gynaecology BST trainees in the National Maternity Hospital, Dublin. The educational programme consisted of didactic lectures, and simulation and practical sessions. A questionnaire reviewing early pregnancy complications was used to assess participant knowledge. Six trainees participated in the programme, with five (83%) answering the questionnaire. The pre-education questionnaire showed a generally poor level of knowledge of early pregnancy complications with 8\\/50 (16%) questions answered correctly. Following the educational intervention there was a statistically significant increase in participant knowledge with 45\\/50 (90%) questions answered correctly. A significant increase in participant knowledge of early pregnancy complications followed our multifaceted educational programme. Study limitations exist, however we have shown the potential value of our educational programme.

  6. Three-dimensional kinematic analysis of active cervical spine motion by using a multifaceted marker device.

    Science.gov (United States)

    Tsunezuka, Hiroaki; Kato, Daishiro; Okada, Satru; Ishihara, Shunta; Shimada, Junichi

    2013-01-01

    Assessing cervical range of motion (CROM) is an important part of the clinical evaluation of patients with conditions such as whiplash syndrome. This study aimed to develop a convenient and accurate system involving multifaceted marker device (MMD)-based assessment of 3-dimensional (3D) dynamic coupled CROM and joint angular velocity. We used an infrared optical tracking system and our newly developed MMD that solved problems such as marker shielding and reflection angle associated with the optical tracking devices and enabled sequential and accurate analysis of the 3D dynamic movement of the polyaxial joint and other structurally complicated joints. The study included 30 asymptomatic young male volunteers (age, 22-27 years). The MMD consisted of 5 surfaces and 5 markers and was attached to the participant's forehead. We measured active CROM (axial rotation, flexion/extension, and lateral bending) and joint angular velocity by the MMD. The MMD was easy to use, safe for patients and operators, could be constructed economically, and generated accurate data such as dynamic coupled CROM and angular velocity.

  7. The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Bishop, Jennifer L.; Thaper, Daksh; Zoubeidi, Amina, E-mail: azoubeidi@prostatecentre.com [The Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver British Columbia, V6H 3Z6 (Canada)

    2014-04-09

    The signal transducer and activator of transcription (STAT)3 governs essential functions of epithelial and hematopoietic cells that are often dysregulated in cancer. While the role for STAT3 in promoting the progression of many solid and hematopoietic malignancies is well established, this review will focus on the importance of STAT3 in prostate cancer progression to the incurable metastatic castration-resistant prostate cancer (mCRPC). Indeed, STAT3 integrates different signaling pathways involved in the reactivation of androgen receptor pathway, stem like cells and the epithelial to mesenchymal transition that drive progression to mCRPC. As equally important, STAT3 regulates interactions between tumor cells and the microenvironment as well as immune cell activation. This makes it a major factor in facilitating prostate cancer escape from detection of the immune response, promoting an immunosuppressive environment that allows growth and metastasis. Based on the multifaceted nature of STAT3 signaling in the progression to mCRPC, the promise of STAT3 as a therapeutic target to prevent prostate cancer progression and the variety of STAT3 inhibitors used in cancer therapies is discussed.

  8. Multi-faceted Rasch measurement and bias patterns in EFL writing performance assessment.

    Science.gov (United States)

    He, Tung-Hsien; Gou, Wen Johnny; Chien, Ya-Chen; Chen, I-Shan Jenny; Chang, Shan-Mao

    2013-04-01

    This study applied multi-faceted Rasch measurement to examine rater bias in the assessment of essays written by college students learning English as a foreign language. Four raters who had received different academic training from four distinctive disciplines applied a six-category rating scale to analytically rate essays on an argumentative topic and on a descriptive topic. FACETS, a Rasch computer program, was utilized to pinpoint bias patterns by analyzing the rater-topic, rater-category, and topic-category interactions. Results showed: argumentative essays were rated more severely than were descriptive essays; the linguistics-major rater was the most lenient rater, while the literature-major rater was the severest one; and the category of language use received the severest ratings, whereas content was given the most lenient ratings. The severity hierarchies for raters, essay topics, and rating categories suggested that raters' academic training and their perceptions of the importance of categories were associated with their bias patterns. Implications for rater training are discussed.

  9. Nitric oxide: a multifaceted regulator of the nitrogen-fixing symbiosis.

    Science.gov (United States)

    Hichri, Imène; Boscari, Alexandre; Castella, Claude; Rovere, Martina; Puppo, Alain; Brouquisse, Renaud

    2015-05-01

    The specific interaction between legumes and Rhizobium-type bacteria leads to the establishment of a symbiotic relationship characterized by the formation of new differentiated organs named nodules, which provide a niche for bacterial nitrogen (N2) fixation. In the nodules, bacteria differentiate into bacteroids with the ability to fix atmospheric N2 via nitrogenase activity. As nitrogenase is strongly inhibited by oxygen, N2 fixation is made possible by the microaerophilic conditions prevailing in the nodules. Increasing evidence has shown the presence of NO during symbiosis, from early interaction steps between the plant and the bacterial partners to N2-fixing and senescence steps in mature nodules. Both the plant and the bacterial partners participate in NO synthesis. NO was found to be required for the optimal establishment of the symbiotic interaction. Transcriptomic analysis at an early stage of the symbiosis showed that NO is potentially involved in the repression of plant defence reactions, favouring the establishment of the plant-microbe interaction. In mature nodules, NO was shown to inhibit N2 fixation, but it was also demonstrated to have a regulatory role in nitrogen metabolism, to play a beneficial metabolic function for the maintenance of the energy status under hypoxic conditions, and to trigger nodule senescence. The present review provides an overview of NO sources and multifaceted effects from the early steps of the interaction to the senescence of the nodule, and presents several approaches which appear to be particularly promising in deciphering the roles of NO in N2-fixing symbioses.

  10. A Multifaceted Prospective Memory Intervention to Improve Medication Adherence: Design of a Randomized Control Trial

    Science.gov (United States)

    Insel, Kathie C.; Einstein, Gilles O.; Morrow, Daniel G.; Hepworth, Joseph T.

    2012-01-01

    Adherence to prescribed antihypertensive agents is critical because control of elevated blood pressure is the single most important way to prevent stroke and other end organ damage. Unfortunately, nonadherence remains a significant problem. Previous interventions designed to improve adherence have demonstrated only small benefits of strategies that target single facets such as understanding medication directions. The intervention described here is informed by prospective memory theory and performance of older adults in laboratory-based paradigms and uses a comprehensive, multifaceted approach to improve adherence. It incorporates multiple strategies designed to support key components of prospective remembering involved in taking medication. The intervention is delivered by nurses in the home with an education control group for comparison. Differences between groups in overall adherence following the intervention and 6 months later will be tested. Systolic and diastolic blood pressure levels also will be examined between groups and as it relates to adherence. Intra-individual regression is planned to examine change in adherence over time and its predictors. Finally, we will examine the association between executive function/working memory and adherence, predicting that adherence will be related to executive/working memory in the control group but not in the intervention group. PMID:23010608

  11. MeCP2: multifaceted roles in gene regulation and neural development.

    Science.gov (United States)

    Cheng, Tian-Lin; Qiu, Zilong

    2014-08-01

    Methyl-CpG-binding protein 2 (MeCP2) is a classic methylated-DNA-binding protein, dysfunctions of which lead to various neurodevelopmental disorders such as Rett syndrome and autism spectrum disorder. Initially recognized as a transcriptional repressor, MeCP2 has been studied extensively and its functions have been expanded dramatically in the past two decades. Recently, it was found to be involved in gene regulation at the post-transcriptional level. MeCP2 represses nuclear microRNA processing by interacting directly with the Drosha/DGCR8 complex. In addition to its multifaceted functions, MeCP2 is remarkably modulated by posttranslational modifications such as phosphorylation, SUMOylation, and acetylation, providing more regulatory dimensions to its functions. The role of MeCP2 in the central nervous system has been studied extensively, from neurons to glia. Future investigations combining molecular, cellular, and physiological methods are necessary for defining the roles of MeCP2 in the brain and developing efficient treatments for MeCP2-related brain disorders.

  12. It Is All in the Blood: The Multifaceted Contribution of Circulating Progenitor Cells in Diabetic Complications

    Directory of Open Access Journals (Sweden)

    Gian Paolo Fadini

    2012-01-01

    Full Text Available Diabetes mellitus (DM is a worldwide growing disease and represents a huge social and healthcare problem owing to the burden of its complications. Micro- and macrovascular diabetic complications arise from excess damage through well-known biochemical pathways. Interestingly, microangiopathy hits the bone marrow (BM microenvironment with features similar to retinopathy, nephropathy and neuropathy. The BM represents a reservoir of progenitor cells for multiple lineages, not limited to the hematopoietic system and including endothelial cells, smooth muscle cells, cardiomyocytes, and osteogenic cells. All these multiple progenitor cell lineages are profoundly altered in the setting of diabetes in humans and animal models. Reduction of endothelial progenitor cells (EPCs along with excess smooth muscle progenitor (SMP and osteoprogenitor cells creates an imbalance that promote the development of micro- and macroangiopathy. Finally, an excess generation of BM-derived fusogenic cells has been found to contribute to diabetic complications in animal models. Taken together, a growing amount of literature attributes to circulating progenitor cells a multi-faceted role in the pathophysiology of DM, setting a novel scenario that puts BM and the blood at the centre of the stage.

  13. Pushing the Limits: Cognitive, Affective, & Neural Plasticity Revealed by an Intensive Multifaceted Intervention

    Directory of Open Access Journals (Sweden)

    Michael David Mrazek

    2016-03-01

    Full Text Available Scientific understanding of how much the adult brain can be shaped by experience requires examination of how multiple influences combine to elicit cognitive, affective, and neural plasticity. Using an intensive multifaceted intervention, we discovered that substantial and enduring improvements can occur in parallel across multiple cognitive and neuroimaging measures in healthy young adults. The intervention elicited substantial improvements in physical health, working memory, standardized test performance, mood, self-esteem, self-efficacy, mindfulness, and life satisfaction. Improvements in mindfulness were associated with increased degree centrality of the insula, greater functional connectivity between insula and somatosensory cortex, and reduced functional connectivity between posterior cingulate cortex and somatosensory cortex. Improvements in working memory and reading comprehension were associated with increased degree centrality of a region within the middle temporal gyrus that was extensively and predominately integrated with the executive control network. The scope and magnitude of the observed improvements represent the most extensive demonstration to date of the considerable human capacity for change. These findings point to higher limits for rapid and concurrent cognitive, affective, and neural plasticity than is widely assumed.

  14. Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis.

    Science.gov (United States)

    Ishikawa, Jun; Takahashi, Nobunori; Matsumoto, Takuya; Yoshioka, Yutaka; Yamamoto, Noriyuki; Nishikawa, Masaya; Hibi, Hideharu; Ishigro, Naoki; Ueda, Minoru; Furukawa, Koichi; Yamamoto, Akihito

    2016-02-01

    Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial hyperplasia and chronic inflammation, which lead to the progressive destruction of cartilage and bone in the joints. Numerous studies have reported that administrations of various types of MSCs improve arthritis symptoms in animal models, by paracrine mechanisms. However, the therapeutic effects of the secreted factors alone, without the cell graft, have been uncertain. Here, we show that a single intravenous administration of serum-free conditioned medium (CM) from human deciduous dental pulp stem cells (SHED-CM) into anti-collagen type II antibody-induced arthritis (CAIA), a mouse model of rheumatoid arthritis (RA), markedly improved the arthritis symptoms and joint destruction. The therapeutic efficacy of SHED-CM was associated with an induction of anti-inflammatory M2 macrophages in the CAIA joints and the abrogation of RANKL expression. SHED-CM specifically depleted of an M2 macrophage inducer, the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (ED-Siglec-9), exhibited a reduced ability to induce M2-related gene expression and attenuate CAIA. SHED-CM also inhibited the RANKL-induced osteoclastogenesis in vitro. Collectively, our findings suggest that SHED-CM provides multifaceted therapeutic effects for treating CAIA, including the ED-Siglec-9-dependent induction of M2 macrophage polarization and inhibition of osteoclastogenesis. Thus, SHED-CM may represent a novel anti-inflammatory and reparative therapy for RA.

  15. Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder

    Directory of Open Access Journals (Sweden)

    Fresno David

    2007-10-01

    Full Text Available Abstract Background Manic-depression or bipolar disorder (BD is a multi-faceted illness with an inevitably complex treatment. Methods This article summarizes the current status of our knowledge and practice of its treatment. Results It is widely accepted that lithium is moderately useful during all phases of bipolar illness and it might possess a specific effectiveness on suicidal prevention. Both first and second generation antipsychotics are widely used and the FDA has approved olanzapine, risperidone, quetiapine, ziprasidone and aripiprazole for the treatment of acute mania. These could also be useful in the treatment of bipolar depression, but only limited data exists so far to support the use of quetiapine monotherapy or the olanzapine-fluoxetine combination. Some, but not all, anticonvulsants possess a broad spectrum of effectiveness, including mixed dysphoric and rapid-cycling forms. Lamotrigine may be effective in the treatment of depression but not mania. Antidepressant use is controversial. Guidelines suggest their cautious use in combination with an antimanic agent, because they are supposed to induce switching to mania or hypomania, mixed episodes and rapid cycling. Conclusion The first-line psychosocial intervention in BD is psychoeducation, followed by cognitive-behavioral therapy. Other treatment options include Electroconvulsive therapy and transcranial magnetic stimulation. There is a gap between the evidence base, which comes mostly from monotherapy trials, and clinical practice, where complex treatment regimens are the rule.

  16. A Multifaceted Role for Myd88-Dependent Signaling in Progression of Murine Mammary Carcinoma

    Science.gov (United States)

    Higgins, Mary J.; Serrano, Antonio; Boateng, Kofi Y.; Parsons, Victoria A.; Phuong, Tiffany; Seifert, Alyssa; Ricca, Jacob M.; Tucker, Kyle C.; Eidelman, Alec S.; Carey, Maureen A.; Kurt, Robert A.

    2016-01-01

    Previous data obtained in our laboratory suggested that there may be constitutive signaling through the myeloid differentiation primary response gene 88 (Myd88)-dependent signaling cascade in murine mammary carcinoma. Here, we extended these findings by showing that, in the absence of an added Toll-like receptor (TLR) agonist, the myddosome complex was preformed in 4T1 tumor cells, and that Myd88 influenced cytoplasmic extracellular signal–regulated kinase (Erk)1/Erk2 levels, nuclear levels of nuclear factor-kappaB (NFκB) and signal transducer and activator of transcription 5 (STAT5), tumor-derived chemokine (C–C motif) ligand 2 (CCL2) expression, and in vitro and in vivo tumor growth. In addition, RNA-sequencing revealed that Myd88-dependent signaling enhanced the expression of genes that could contribute to breast cancer progression and genes previously associated with poor outcome for patients with breast cancer, in addition to suppressing the expression of genes capable of inhibiting breast cancer progression. Yet, Myd88-dependent signaling in tumor cells also suppressed expression of genes that could contribute to tumor progression. Collectively, these data revealed a multifaceted role for Myd88-dependent signaling in murine mammary carcinoma. PMID:27812285

  17. Cybersecurity vulnerabilities in medical devices: a complex environment and multifaceted problem

    Directory of Open Access Journals (Sweden)

    Williams PAH

    2015-07-01

    Full Text Available Patricia AH Williams, Andrew J Woodward eHealth Research Group and Security Research Institute, Edith Cowan University, Perth, WA, Australia Abstract: The increased connectivity to existing computer networks has exposed medical devices to cybersecurity vulnerabilities from which they were previously shielded. For the prevention of cybersecurity incidents, it is important to recognize the complexity of the operational environment as well as to catalog the technical vulnerabilities. Cybersecurity protection is not just a technical issue; it is a richer and more intricate problem to solve. A review of the factors that contribute to such a potentially insecure environment, together with the identification of the vulnerabilities, is important for understanding why these vulnerabilities persist and what the solution space should look like. This multifaceted problem must be viewed from a systemic perspective if adequate protection is to be put in place and patient safety concerns addressed. This requires technical controls, governance, resilience measures, consolidated reporting, context expertise, regulation, and standards. It is evident that a coordinated, proactive approach to address this complex challenge is essential. In the interim, patient safety is under threat. Keywords: cybersecurity, security, safety, wireless, risk, medical devices

  18. 76 FR 72391 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-11-23

    ... Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Revised Defense Logistics Agency Regulation (DLAR) 1000.22. SUMMARY: On May 18, 2011, the Defense Logistics Agency (DLA) published a Notice of...

  19. 76 FR 53119 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

    Science.gov (United States)

    2011-08-25

    ... Office of the Secretary Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Comment Addressed on Notice of Availability (NOA) of Revised Defense Logistics Agency Regulation (DLAR...

  20. Technical Soddi Defenses: The Trojan Horse Defense Revisited

    Directory of Open Access Journals (Sweden)

    Chad Steel

    2014-12-01

    Full Text Available In 2004, the Trojan horse defense was at a crossroads, with two child pornography cases where it was successfully employed in the United Kingdom, resulting in acquittals.  The original Trojan horse defense has now become part of the more general “technical SODDI” defense, which includes the possibility of unknown actors using unsecured Wi-Fi connections or having physical access to a computer to perform criminal acts.  In the past ten years, it has failed to be effective in the United States for criminal cases, with no published acquittals in cases where it was the primary defense.  In the criminal cases where it has been used as leverage in plea negotiations, there has been either poor forensics performed by the prosecution or political pressure to resolve a matter.  On the civil side, however, the defense has been wildly successful, effectively shutting down large John Doe copyright infringement litigation against non-commercial violators.  

  1. A multifaceted workplace intervention for low back pain in nurses' aides: a pragmatic stepped wedge cluster randomised controlled trial.

    Science.gov (United States)

    Rasmussen, Charlotte Diana Nørregaard; Holtermann, Andreas; Bay, Hans; Søgaard, Karen; Birk Jørgensen, Marie

    2015-09-01

    This study established the effectiveness of a workplace multifaceted intervention consisting of participatory ergonomics, physical training, and cognitive-behavioural training (CBT) for low back pain (LBP). Between November 2012 and May 2014, we conducted a pragmatic stepped wedge cluster randomised controlled trial with 594 workers from eldercare workplaces (nursing homes and home care) randomised to 4 successive time periods, 3 months apart. The intervention lasted 12 weeks and consisted of 19 sessions in total (physical training [12 sessions], CBT [2 sessions], and participatory ergonomics [5 sessions]). Low back pain was the outcome and was measured as days, intensity (worst pain on a 0-10 numeric rank scale), and bothersomeness (days) by monthly text messages. Linear mixed models were used to estimate the intervention effect. Analyses were performed according to intention to treat, including all eligible randomised participants, and were adjusted for baseline values of the outcome. The linear mixed models yielded significant effects on LBP days of -0.8 (95% confidence interval [CI], -1.19 to -0.38), LBP intensity of -0.4 (95% CI, -0.60 to -0.26), and bothersomeness days of -0.5 (95% CI, -0.85 to -0.13) after the intervention compared with the control group. This study shows that a multifaceted intervention consisting of participatory ergonomics, physical training, and CBT can reduce LBP among workers in eldercare. Thus, multifaceted interventions may be relevant for improving LBP in a working population.

  2. Uncovering the multifaceted-self in the domain of negative traits: on the muted expression of negative self-knowledge.

    Science.gov (United States)

    Cheung, Wing-Yee; Wildschut, Tim; Sedikides, Constantine; Pinter, Brad

    2014-04-01

    The multifaceted-self effect is the ascription of more traits to self than others. Consensus is that this effect occurs for positive, but not negative, traits. We propose that the effect also occurs for negative traits when they can be endorsed with low intensity ("I am a little bit lazy"), thereby circumventing self-protection concerns. In Experiment 1, the multifaceted-self effect occurred for positive, but not negative, traits on a high-intensity trait-endorsement measure. However, it occurred irrespective of trait valence on a low-intensity trait-endorsement measure. In Experiment 2, the multifaceted-self effect occurred for positive, but not negative, traits on a strong trait-endorsement measure. However, it occurred irrespective of trait valence on a diminuted trait-endorsement measure--a finding conceptually replicated in Experiment 3. In Experiment 4, participants spontaneously adopted diminutive terms ("a little bit") when describing their negative traits. Individuals reconcile negative self-knowledge with self-protection concerns by expressing it in muted terms.

  3. Description of a multifaceted rehabilitation program including overground gait training for a child with cerebral palsy: A case report.

    Science.gov (United States)

    Farrell, Elizabeth; Naber, Erin; Geigle, Paula

    2010-01-01

    This case describes the outcomes of a multifaceted rehabilitation program including body weight-supported overground gait training (BWSOGT) in a nonambulatory child with cerebral palsy (CP) and the impact of this treatment on the child's functional mobility. The patient is a nonambulatory 10-year-old female with CP who during an inpatient rehabilitation stay participated in direct, physical therapy 6 days per week for 5 weeks. Physical therapy interventions included stretching of her bilateral lower extremities, transfer training, bed mobility training, balance training, kinesiotaping, supported standing in a prone stander, two trials of partial weight-supported treadmill training, and for 4 weeks, three to five times per week, engaged in 30 minutes of BWSOGT using the Up n' go gait trainer, Lite Gait Walkable, and Rifton Pacer gait trainer. Following the multifaceted rehabilitation program, the patient demonstrated increased step initiation, increased weight bearing through bilateral lower extremities, improved bed mobility, and increased participation in transfers. The child's Gross Motor Functional Measure (GMFM) scores increased across four dimensions and her Physical Abilities and Mobility Scale (PAMS) increased significantly. This case report illustrates that a multifaceted rehabilitation program including BWSOGT was an effective intervention strategy to improve functional mobility in this nonambulatory child with CP.

  4. Assessment of multifaceted environmental issues and model development of an Indo-Burma hotspot region.

    Science.gov (United States)

    Rai, Prabhat Kumar

    2012-01-01

    The present article provides a multifaceted critical research review on environmental issues intimately related with the socio-economy of North East India (NE), a part of Indo-Burma hotspot. Further, the article addresses the issue of sustainable development of NE India through diverse ecological practices inextricably linked with traditional ecological knowledge (TEK). The biodiversity of NE India comprises endemic floral diversity, particularly medicinal plants of importance to pharmaceutical industry, and unique faunal diversity. Nevertheless, it is very unfortunate that this great land of biodiversity is least explored taxonomically as well as biotechnologically, probably due to geographical and political constraints. Different anthropogenic and socio-economic factors have perturbed the pristine ecology of this region, leading to environmental degradation. Also, the practice of unregulated shifting cultivation (jhooming), bamboo flowering, biological invasions and anthropogenic perturbations to biodiversity exacerbate the gloomy situation. Instead of a plethora of policies, the TEK of NE people may be integrated with modern scientific knowledge in order to conserve the environment which is the strong pillar for socio-economic sector here. The aforesaid approach can be practiced in NE India through the broad implementation and extension of agroforestry practices. Further, case studies on Apatanis, ethnomedicinal plants use by indigenous tribal groups and sacred forests are particularly relevant in the context of conservation of environmental health in totality while addressing the socioeconomic impact as well. In context with the prevailing scenarios in this region, we developed an eco-sustainable model for natural resource management through agroforestry practices in order to uplift the social as well as environmental framework.

  5. A Multifaceted Approach to Modernizing NASA's Advanced Multi-Mission Operations System (AMMOS) System Architecture

    Science.gov (United States)

    Estefan, Jeff A.; Giovannoni, Brian J.

    2014-01-01

    The Advanced Multi-Mission Operations Systems (AMMOS) is NASA's premier space mission operations product line offering for use in deep-space robotic and astrophysics missions. The general approach to AMMOS modernization over the course of its 29-year history exemplifies a continual, evolutionary approach with periods of sponsor investment peaks and valleys in between. Today, the Multimission Ground Systems and Services (MGSS) office-the program office that manages the AMMOS for NASA-actively pursues modernization initiatives and continues to evolve the AMMOS by incorporating enhanced capabilities and newer technologies into its end-user tool and service offerings. Despite the myriad of modernization investments that have been made over the evolutionary course of the AMMOS, pain points remain. These pain points, based on interviews with numerous flight project mission operations personnel, can be classified principally into two major categories: 1) information-related issues, and 2) process-related issues. By information-related issues, we mean pain points associated with the management and flow of MOS data across the various system interfaces. By process-related issues, we mean pain points associated with the MOS activities performed by mission operators (i.e., humans) and supporting software infrastructure used in support of those activities. In this paper, three foundational concepts-Timeline, Closed Loop Control, and Separation of Concerns-collectively form the basis for expressing a set of core architectural tenets that provides a multifaceted approach to AMMOS system architecture modernization intended to address the information- and process-related issues. Each of these architectural tenets will be further explored in this paper. Ultimately, we envision the application of these core tenets resulting in a unified vision of a future-state architecture for the AMMOS-one that is intended to result in a highly adaptable, highly efficient, and highly cost

  6. Improved adherence to colposcopy through nurse-led telephone counselling and multifaceted patient support.

    Science.gov (United States)

    Dunn, Sheila; Rossiter, Lea; Ferne, Jessica; Barnes, Erin; Wu, Wei

    2013-08-01

    In 2009, an on-site diagnostic colposcopy clinic was established within a large, urban sexual health clinic to enhance follow-up of abnormal cervical cancer screening among vulnerable women, including those who are uninsured. This service model uses a family physician colposcopist and a colposcopy nurse who provides pre-visit counselling, telephone reminders, patient-tailored ongoing support during the diagnostic process, and tracking of missed appointments. This study examined whether this program was associated with improved adherence to the first colposcopy visit after an abnormal Papanicolau smear among a high needs population. We conducted a retrospective chart review of women referred for colposcopy between January 2007 and September 2010, and examined non-adherence before (pre-group) and after (post-group) establishment of the on-site program. Univariable and multivariable logistic regression was used to examine patient and clinical factors associated with non-adherence. Six hundred eighty-five women were referred during the study period, with 302 in the pre-group and 383 in the post-group. Non-adherence to the first colposcopy visit fell from 13% to 4% after institution of the on-site service. Pre-group status, cervical screening performed at an abortion-related visit (as opposed to a contraception or cervical screening visit), parity ≥ 1 and younger age were all associated with non-adherence in the multivariable analysis. An on-site colposcopy service that incorporated multifaceted, client-tailored support throughout the diagnostic process significantly reduced non-attendance for an initial colposcopy visit in an urban sexual health clinic population. Broader adoption of this model could improve effectiveness of cervical cancer screening programs. However, future research should determine which specific elements of the model are more important in influencing adherence rates.

  7. Reducing preterm birth by a statewide multifaceted program: an implementation study.

    Science.gov (United States)

    Newnham, John P; White, Scott W; Meharry, Suzanne; Lee, Han-Shin; Pedretti, Michelle K; Arrese, Catherine A; Keelan, Jeffrey A; Kemp, Matthew W; Dickinson, Jan E; Doherty, Dorota A

    2017-05-01

    A comprehensive preterm birth prevention program was introduced in the state of Western Australia encompassing new clinical guidelines, an outreach program for health care practitioners, a public health program for women and their families based on print and social media, and a new clinic at the state's sole tertiary level perinatal center for referral of those pregnant women at highest risk. The initiative had the single aim of safely lowering the rate of preterm birth. The objective of the study was to evaluate the outcomes of the initiative on the rates of preterm birth both statewide and in the single tertiary level perinatal referral center. This was a prospective population-based cohort study of perinatal outcomes before and after 1 full year of implementation of the preterm birth prevention program. In the state overall, the rate of singleton preterm birth was reduced by 7.6% and was lower than in any of the preceding 6 years. This reduction amounted to 196 cases relative to the year before the introduction of the initiative and the effect extended from the 28-31 week gestational age group onward. Within the tertiary level center, the rate of preterm birth in 2015 was also significantly lower than in the preceding years. A comprehensive and multifaceted preterm birth prevention program aimed at both health care practitioners and the general public, operating within the environment of a government-funded universal health care system can significantly lower the rate of early birth. Further research is now required to increase the effect and to determine the relative contributions of each of the interventions. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  8. The multifaceted origin of taurine cattle reflected by the mitochondrial genome.

    Directory of Open Access Journals (Sweden)

    Alessandro Achilli

    Full Text Available A Neolithic domestication of taurine cattle in the Fertile Crescent from local aurochsen (Bos primigenius is generally accepted, but a genetic contribution from European aurochsen has been proposed. Here we performed a survey of a large number of taurine cattle mitochondrial DNA (mtDNA control regions from numerous European breeds confirming the overall clustering within haplogroups (T1, T2 and T3 of Near Eastern ancestry, but also identifying eight mtDNAs (1.3% that did not fit in haplogroup T. Sequencing of the entire mitochondrial genome showed that four mtDNAs formed a novel branch (haplogroup R which, after the deep bifurcation that gave rise to the taurine and zebuine lineages, constitutes the earliest known split in the mtDNA phylogeny of B. primigenius. The remaining four mtDNAs were members of the recently discovered haplogroup Q. Phylogeographic data indicate that R mtDNAs were derived from female European aurochsen, possibly in the Italian Peninsula, and sporadically included in domestic herds. In contrast, the available data suggest that Q mtDNAs and T subclades were involved in the same Neolithic event of domestication in the Near East. Thus, the existence of novel (and rare taurine haplogroups highlights a multifaceted genetic legacy from distinct B. primigenius populations. Taking into account that the maternally transmitted mtDNA tends to underestimate the extent of gene flow from European aurochsen, the detection of the R mtDNAs in autochthonous breeds, some of which are endangered, identifies an unexpected reservoir of genetic variation that should be carefully preserved.

  9. USER-CENTRIC PERSONALIZED MULTIFACET MODEL TRUST IN ONLINE SOCIAL NETWORK

    Directory of Open Access Journals (Sweden)

    Liu Ban Chieng

    2014-12-01

    Full Text Available Online Social Network (OSN has become the most popular platform on the Internet that can provide an interesting and creative ways to communicate, sharing and meets with peoples. As OSNs mature, issues regarding proper use of OSNs are also growing. In this research, the challenges of online social networks have been investigated. The current issues in some of the Social Network Sites are being studied and compared. Cyber criminals, malware attacks, physical threat, security and usability and some privacy issues have been recognized as the challenges of the current social networking sites. Trust concerns have been raised and the trustworthiness of social networking sites has been questioned. Currently, the trust in social networks is using the single- faceted approach, which is not well personalized, and doesn’t account for the subjective views of trust, according to each user, but only the general trust believes of a group of population. The trust level towards a person cannot be calculated and trust is lack of personalization. From our initial survey, we had found that most people can share their information without any doubts on OSN but they normally do not trust all their friends equally and think there is a need of trust management. We had found mixed opinions in relation to the proposed rating feature in OSNs too. By adopting the idea of multi-faceted trust model, a user-centric model that can personalize the comments/photos in social network with user’s customized traits of trust is proposed. This model can probably solve many of the trust issues towards the social networking sites with personalized trust features, in order to keep the postings on social sites confidential and integrity.

  10. Evaluating the effectiveness of a tailored multifaceted performance feedback intervention to improve the quality of care: protocol for a cluster randomized trial in intensive care

    NARCIS (Netherlands)

    Veer, S.N. van der; Vos, M.L. de; Jager, K.J.; Voort, P.H. van der; Peek, N.; Westert, G.P.; Graafmans, W.C.; Keizer, N.F. de

    2011-01-01

    ABSTRACT: BACKGROUND: Feedback is potentially effective in improving the quality of care. However, merely sending reports is no guarantee that performance data are used as input for systematic quality improvement (QI). Therefore, we developed a multifaceted intervention tailored to prospectively

  11. Improving patient-centeredness of fertility care using a multifaceted approach: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Huppelschoten Aleida G

    2012-09-01

    Full Text Available Abstract Background Beside traditional outcomes of safety and (cost-effectiveness, the Institute of Medicine states patient-centeredness as an independent outcome indicator to evaluate the quality of healthcare. Providing patient-centered care is important because patients want to be heard for their ideas and concerns. Healthcare areas associated with high emotions and intensive treatment periods could especially benefit from patient-centered care. How care can become optimally improved in patient-centeredness is unknown. Therefore, we will conduct a study in the context of Dutch fertility care to determine the effects of a multifaceted approach on patient-centeredness, patients’ quality of life (QoL and levels of distress. Our aims are to investigate the effectiveness of a multifaceted approach and to identify determinants of a change in the level of patient-centeredness, patients’ QoL and distress levels. This paper presents the study protocol. Methods/Design In a cluster-randomized trial in 32 Dutch fertility clinics the effects of a multifaceted approach will be determined on the level of patient-centeredness (Patient-centredness Questionnaire – Infertility, patients’ QoL (FertiQoL and levels of distress (SCREENIVF. The multifaceted approach includes audit and feedback, educational outreach visits and patient-mediated interventions. Potential determinants of a change in patient-centeredness, patients’ QoL and levels of distress will be collected by an addendum to the patients’ questionnaire and a professionals’ questionnaire. The latter includes the Organizational Culture Assessment Instrument about the clinic’s culture as a possible determinant of an increase in patient-centered care. Discussion The study is expected to yield important new evidence about the effects of a multifaceted approach on levels of patient-centeredness, patients’ QoL and distress in fertility care. Furthermore, determinants associated with a change

  12. Effectiveness of a multifaceted podiatry intervention to prevent falls in community dwelling older people with disabling foot pain: randomised controlled trial

    OpenAIRE

    Spink, Martin J; Menz, Hylton B.; Fotoohabadi, Mohammad R; Wee, Elin; Landorf, Karl B.; Hill, Keith D; Stephen R Lord

    2011-01-01

    Objective To determine the effectiveness of a multifaceted podiatry intervention in preventing falls in community dwelling older people with disabling foot pain. Design Parallel group randomised controlled trial. Setting University health sciences clinic in Melbourne, Australia. Participants 305 community dwelling men and women (mean age 74 (SD 6) years) with disabling foot pain and an increased risk of falling. 153 were allocated to a multifaceted podiatry intervention and 152 to routine pod...

  13. The Inflammasome in Host Defense

    Directory of Open Access Journals (Sweden)

    Gang Chen

    2009-12-01

    Full Text Available Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome, a protein complex that activates caspase-1 in response to several stimuli. Caspase-1 activation leads to processing and secretion of pro-inflammatory cytokines such as interleukin (IL-1β and IL-18. Here, we discuss recent advances in the inflammasome field with an emphasis on host defense. We also compare differential requirements for inflammasome activation in dendritic cells, macrophages and monocytes.

  14. Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke

    Science.gov (United States)

    Schulze, Juliane

    2017-01-01

    Immune cells can significantly predict and affect the clinical outcome of stroke. In particular, the neutrophil-to-lymphocyte ratio was shown to predict hemorrhagic transformation and the clinical outcome of stroke; however, the immunological mechanisms underlying these effects are poorly understood. Neutrophils are the first cells to invade injured tissue following focal brain ischemia. In these conditions, their proinflammatory properties enhance tissue damage and may promote ischemic incidences by inducing thrombus formation. Therefore, they constitute a potential target for therapeutic approaches and prevention of stroke. Indeed, in animal models of focal brain ischemia, neutrophils have been targeted with successful results. However, even in brain lesions, neutrophils also exert beneficial effects, because they are involved in triggering immunological removal of cell debris. Furthermore, intact neutrophil function is essential for maintaining immunological defense against bacterial infections. Several studies have demonstrated that stroke-derived neutrophils displayed impaired bacterial defense capacity. Because infections are known to impair the clinical course of stroke, therapeutic interventions that target neutrophils should preserve or even restore their function outside the central nervous system (CNS). This complex situation requires well-tailored therapeutic approaches that can effectively tackle immune cell invasion in the brain but avoid increasing poststroke infections. PMID:28331857

  15. Involvement of fengycin-type lipopeptides in the multifaceted biocontrol potential of Bacillus subtilis.

    Science.gov (United States)

    Ongena, Marc; Jacques, Philippe; Touré, Yacine; Destain, Jacqueline; Jabrane, Abdelhamid; Thonart, Philippe

    2005-11-01

    In this work, the potential of Bacillus subtilis strain M4 at protecting plants against fungal diseases was demonstrated in different pathosystems. We provide evidence for the role of secreted lipopeptides, and more particularly of fengycins, in the protective effect afforded by the strain against damping-off of bean seedlings caused by Pythium ultimum and against gray mold of apple in post-harvest disease. This role was demonstrated by the strong biocontrol activity of lipopeptide-enriched extracts and through the detection of inhibitory quantities of fengycins in infected tissues. Beside such a direct antagonism of the pathogen, we show that root pre-inoculation with M4 enabled the host plant to react more efficiently to subsequent pathogen infection on leaves. Fengycins could also be involved in this systemic resistance-eliciting effect of strain M4, as these molecules may induce the synthesis of plant phenolics involved in or derived from the defense-related phenylpropanoid metabolism. Much remains to be discovered about the mechanisms by which Bacillus spp suppress disease. Through this study on strain M4, we reinforce the interest in B. subtilis as a pathogen antagonist and plant defense-inducing agent. The secretion of cyclic fengycin-type lipopeptides may be tightly related to the expression of these two biocontrol traits.

  16. Defense Acquisition Policy and Defense Industrial Base Reinforcement Strategy - Enhancing the International Competitiveness of the Korean National Defense Industry

    Science.gov (United States)

    2008-04-23

    Korea Defense Industry Association (KDIA). (2007). Annual management review of Korean Defense Industry. Seoul: Author. Lee, D.O. (2000...COMPETITIVENESS OF THE KOREAN NATIONAL DEFENSE INDUSTRY Published: 23 April 2008 by Dr. Dae Ok Lee 5th Annual Acquisition Research Symposium of the...International Competitiveness of the Korean National Defense Industry 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

  17. Defense Acquisition Performance Assessment Report

    Science.gov (United States)

    2006-01-01

    Incorporated – “Changing the System” HeLLeR , TRiCiA A., Deputy Director of Congressional Support, Technical and Analytical Support, USAF A-Team...Interview Recorder” HeLLieR, RiCHARD, Director of Air Force Programs, United Technologies – “Joint Stars System” HeRMAN , DR. ROBeRT, Member, Defense

  18. Defense Financial and Investment Review

    Science.gov (United States)

    1985-06-01

    to direct its attention to problems such as profit policy and the management and investment practices of defense contractors. Prorit Study 󈨖 In 1982...I \\-L 10 NO ADJUSTMENT 46- 70 71 72 73 74 75 76 77 78 79 80 81 82 83 Sources: Touche Ross; Prorit 󈨐 V-34

  19. In Defense of Darwin's Theory.

    Science.gov (United States)

    Naylor, Bruce G.; Handford, Paul

    1985-01-01

    Examines issues regarding the defensibility and utility of natural selection as a scientific theory, focusing on the process of population change over time. Topics considered include criticisms of Darwinian theory, tautology and the meaning of fitness, the ability of theories to predict and explain, and the sufficiency of natural selection. (DH)

  20. Systemic defense signaling in tomato

    Institute of Scientific and Technical Information of China (English)

    LI Changbao; SUN Jiaqiang; JIANG Hongling; WU Xiaoyan; LI Chuanyou

    2005-01-01

    The wound-inducible expression of proteinase inhibitors (PIs) genes in tomato provides a powerful model system to elucidate the signal transduction pathway of sys- temic defense response. An increasing body of evidence indi- cates that systemin and jasmonic acid (JA) work in the same signaling pathway to activate the expression of PIs and other defense-related genes. However, little is known about how systemin and JA interact to regulate cell to cell communica- tion over long distances. Genetic analysis of the systemin/JA signaling pathway in tomato plants provides a unique opportunity to dissect the mechanism by which peptide and oxylipin signals interact to coordinate systemic expression of defense-related genes. Previously, it has been proposed that systemin is the long-distance mobile signal for systemic expression of defense related genes. However, recent genetic approach provided new evidence that jasmonic acid, rather than systemin, functions as the systemic wound signal, and that the peptide systemin works to regulate the biosynthesis of JA.

  1. Soviet debate on missile defense

    Energy Technology Data Exchange (ETDEWEB)

    Parrott, B.

    1987-04-01

    Although the Strategic Defense Initiative (SDI) is meant to cope with the danger of a Soviet nuclear attack, the recent US debate over SDI has paid surprisingly little attention to Soviet views of ballistic missile defense. Despite the existence of a substantial body of pertinent scholarship, the debate has failed to take adequate account of major changes in Soviet ballistic missile defense policy since the mid-1960s. It has also neglected the links between current Soviet military policy and broader Soviet political and economic choices. The Soviets regard SDI not as a novel undertaking to reduce the risks of nuclear war but as an extension of the geopolitical competition between the superpowers. This competition has been dominated in the 1980s, in the Soviet view, by sharply increased US assertiveness and the decline of detente. Viewing SDI as a manifestation of these general trends, Soviet decision makers find the prospect of an unregulated race in ballistic missile defenses and military space technologies deeply unsettling. The deterioration of superpower relations has raised serious doubts in Moscow about the wisdom of Soviet external policy during the 1970s and has provoked sharp internal differences over policy toward the US. Already highly suspicious of the Reagan administration, the elite is united by a general conviction that SDI is an American gambit that may ultimately undercut past Soviet strategic gains and pose a grave new threat to Soviet security. 14 references.

  2. What Happens After the Defense?

    DEFF Research Database (Denmark)

    Feldtmann, Birgit

    2015-01-01

    who has attempted to attack the master’s vessel and whose distress is the direct result of lawful self-defense by PCASP? This is the question at the heart of this article, which argues that there are certain post incident obligations and that it is crucial to address these obligations at the flag...

  3. Multidimensional Perfectionism and Ego Defenses

    Science.gov (United States)

    Dickinson, Wendy L.; Ashby, Jeffrey S.

    2005-01-01

    This study examined the relationship between multidimensional perfectionism and ego defense style among 130 college students. Cluster analysis results facilitated the identification of groups of adaptive perfectionists, maladaptive perfectionists, and non-perfectionists. The researchers found that identified maladaptive perfectionists used…

  4. Multidimensional Perfectionism and Ego Defenses

    Science.gov (United States)

    Dickinson, Wendy L.; Ashby, Jeffrey S.

    2005-01-01

    This study examined the relationship between multidimensional perfectionism and ego defense style among 130 college students. Cluster analysis results facilitated the identification of groups of adaptive perfectionists, maladaptive perfectionists, and non-perfectionists. The researchers found that identified maladaptive perfectionists used…

  5. Analytics for Cyber Network Defense

    Energy Technology Data Exchange (ETDEWEB)

    Plantenga, Todd. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Kolda, Tamara Gibson [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2011-06-01

    This report provides a brief survey of analytics tools considered relevant to cyber network defense (CND). Ideas and tools come from elds such as statistics, data mining, and knowledge discovery. Some analytics are considered standard mathematical or statistical techniques, while others re ect current research directions. In all cases the report attempts to explain the relevance to CND with brief examples.

  6. Inflation Adjustments for Defense Acquisition

    Science.gov (United States)

    2014-10-01

    Airframe Total airframe contractor furnished equipment ( CFE ) Total airframe CFE 9 entries (forward fuselage, center fuselage, wing, empennage...etc.) Avionics Total electronics CFE and government- furnished equipment (GFE) Total avionics 16 entries (radar, integrated processor...Relationship CFE Contractor Furnished Equipment CNI Communication, Navigation, Identification DoD Department of Defense FCCM Facilities Capital Cost

  7. Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 5. Governmental Responsibilities for Civil Defense.

    Science.gov (United States)

    Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

    A description of the laws and orders that provide necessary legal authorization for civil defense activities is provided. In addition, an outline of the responsibilities of all governments and the role of the private sector in civil defense is presented. Topics discussed include: (1) Legal authority for civil defense, (2) Civil defense…

  8. Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 1. Civil Defense - Protection Against What?

    Science.gov (United States)

    Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

    An explanation of the need for civil defense in nuclear and natural disasters is presented. A brief historical background of civil defense is given. Major topics include: (1) Types of disasters, (2) Probable objectives of a nuclear attack on the United States, (3) The major defensive measures against a nuclear attack, (4) Some reasons for low…

  9. Multifaceted intervention to improve obstetric practices: The OPERA cluster-randomized controlled trial.

    Science.gov (United States)

    Dupont, Corinne; Winer, Norbert; Rabilloud, Muriel; Touzet, Sandrine; Branger, Bernard; Lansac, Jacques; Gaucher, Laurent; Duclos, Antoine; Huissoud, Cyril; Boutitie, Florent; Rudigoz, René-Charles; Colin, Cyrille

    2017-08-01

    Suboptimal care contributes to perinatal morbidity and mortality. We investigated the effects of a multifaceted program designed to improve obstetric practices and outcomes. A cluster-randomized trial was conducted from October 2008 to November 2010 in 95 French maternity units randomized either to receive an information intervention about published guidelines or left to apply them freely. The intervention combined an outreach visit with a morbidity/mortality conference (MMC) to review perinatal morbidity/mortality cases. Within the intervention group, the units were randomized to have MMCs with or without clinical psychologists. The primary outcome was the rate of suboptimal care among perinatal morbidity/mortality cases. The secondary outcomes included the rate of suboptimal care among cases of morbidity, the rate of suboptimal care among cases of mortality, the rate of avoidable morbidity and/or mortality cases, and the incidence of, morbidity and/or mortality. A mixed logistic regression model with random intercept was used to quantify the effect of the intervention on the main outcome. The study reviewed 2459 cases of morbidity or mortality among 165,353 births. The rate of suboptimal care among morbidity plus mortality cases was not significantly lower in the intervention than in the control group (8.1% vs. 10.6%, OR [95% CI]: 0.75 [0.50-1.12], p=0.15. However, the cases of suboptimal care among morbidity cases were significantly lower in the intervention group (7.6% vs. 11.5%, 0.62 [0.40-0.94], p=0.02); the incidence of perinatal morbidity was also lower (7.0 vs. 8.1‰, p=0.01). No differences were found between psychologist-backed and the other units. The intervention reduced the rate of suboptimal care mainly in morbidity cases and the incidence of morbidity but did not succeed in improving morbidity plus mortality combined. More clear-cut results regarding mortality require a longer study period and the inclusion of structures that intervene before and

  10. Hormetic response triggers multifaceted anti-oxidant strategies in immature king penguins (Aptenodytes patagonicus).

    Science.gov (United States)

    Rey, Benjamin; Dégletagne, Cyril; Bodennec, Jacques; Monternier, Pierre-Axel; Mortz, Mathieu; Roussel, Damien; Romestaing, Caroline; Rouanet, Jean-Louis; Tornos, Jeremy; Duchamp, Claude

    2016-08-01

    Repeated deep dives are highly pro-oxidative events for air-breathing aquatic foragers such as penguins. At fledging, the transition from a strictly terrestrial to a marine lifestyle may therefore trigger a complex set of anti-oxidant responses to prevent chronic oxidative stress in immature penguins but these processes are still undefined. By combining in vivo and in vitro approaches with transcriptome analysis, we investigated the adaptive responses of sea-acclimatized (SA) immature king penguins (Aptenodytes patagonicus) compared with pre-fledging never-immersed (NI) birds. In vivo, experimental immersion into cold water stimulated a higher thermogenic response in SA penguins than in NI birds, but both groups exhibited hypothermia, a condition favouring oxidative stress. In vitro, the pectoralis muscles of SA birds displayed increased oxidative capacity and mitochondrial protein abundance but unchanged reactive oxygen species (ROS) generation per g tissue because ROS production per mitochondria was reduced. The genes encoding oxidant-generating proteins were down-regulated in SA birds while mRNA abundance and activity of the main antioxidant enzymes were up-regulated. Genes encoding proteins involved in repair mechanisms of oxidized DNA or proteins and in degradation processes were also up-regulated in SA birds. Sea life also increased the degree of fatty acid unsaturation in muscle mitochondrial membranes resulting in higher intrinsic susceptibility to ROS. Oxidative damages to protein or DNA were reduced in SA birds. Repeated experimental immersions of NI penguins in cold-water partially mimicked the effects of acclimatization to marine life, modified the expression of fewer genes related to oxidative stress but in a similar way as in SA birds and increased oxidative damages to DNA. It is concluded that the multifaceted plasticity observed after marine life may be crucial to maintain redox homeostasis in active tissues subjected to high pro-oxidative pressure

  11. John Grant and the multifaceted nature of true professionalism: Personal perspective

    Energy Technology Data Exchange (ETDEWEB)

    Baer, Donald R.; Artyushkova, Kateryna; Fulghum, Julia E.; Powell, Cedric J.; Sherwood, Peter M.; Surman, David J.; Watts, John F.

    2016-04-07

    Consideration of the elements that contribute to professional and scientific impact is relevant in a volume honoring John Grant for two reasons. First, John has contributed in many ways to both advancing the methodology and the practical application of surface-analytical tools to understanding surfaces and interfaces of technological importance. The second reason is a little more complex. In an era when there is an effort to quantify contributions in various ways (e.g., citations, H-index, number of publications) and when social media seems, at least anecdotally, to lead a younger generation of scientists to be less involved in traditional professional activities, it is appropriate to examine the nature of the activities that make a lasting contribution to the advancement of science and technology and the professional community that makes progress possible. The multifaceted nature of John’s professional activities provides an appropriate background for exploring the nature of professionalism. With no reservations one can say that the foundation of professionalism is rooted in a scientist’s expertise in some area of research or practice. This expertise might be measured in numerous ways depending upon the field and could include numbers of publications, citations, patents, problems solved, research support obtained, or students produced. These “products” may or may not be readily visible to the community at large. Chuck Wagner – a pioneer in XPS, developer of an empirical set of XPS sensitivity factors and the modified Auger-parameter plot, and winner of the AVS Nerken Award in 1989 – observed that he could not publish or talk about 90% of the work he had done when working for Shell Oil. However, based on XPS capability developments that he could publish, he had a major impact on the development and application of XPS. To some degree John Grant’s research fits this model as well. Much of his early work at the Air Force Materials Research Laboratory was

  12. Department of Defense PERSEREC (DOD PERSEREC)

    Data.gov (United States)

    Social Security Administration — The purpose of this agreement is for SSA to verify SSN information for Defense Manpower Data Center (DMDC) of the Department of Defense. DMDC will use the SSA data...

  13. 22 CFR 120.6 - Defense article.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Defense article. 120.6 Section 120.6 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.6 Defense article. Defense article means any item or technical data designated in § 121.1 of this...

  14. 22 CFR 120.9 - Defense service.

    Science.gov (United States)

    2010-04-01

    ... Defense service. (a) Defense service means: (1) The furnishing of assistance (including training) to foreign persons, whether in the United States or abroad in the design, development, engineering... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Defense service. 120.9 Section 120.9...

  15. Defense Procurement Strategy for a Globalized Industry

    Science.gov (United States)

    2007-11-02

    QDR,” DefenseNews, 8 November 2004, p. 4. 3 Vago Muradain, “Finalizing Transformation,” DefenseNews, 8 November 2004, p. 34. 4 Hugo Posey and Ben...Interavia, Summer 2004, 34-36. Munton, Bob, and Brinley Salzmann. “U.K.’s Growing Contols.” DefenseNews, 25 October 2004, 96. Muradain, Vago

  16. Impact of a multifaceted educational intervention including serious games to improve the management of invasive candidiasis in critically ill patients.

    Science.gov (United States)

    Ferrer, R; Zaragoza, R; Llinares, P; Maseda, E; Rodríguez, A; Quindós, G

    Infections caused by Candida species are common in critically ill patients and contribute to significant morbidity and mortality. The EPICO Project (Epico 1 and Epico 2.0 studies) recently used a Delphi approach to elaborate guidelines for the diagnosis and treatment of this condition in critically ill adult patients. We aimed to evaluate the impact of a multifaceted educational intervention based on the Epico 1 and Epico 2.0 recommendations. Specialists anonymously responded to two online surveys before and after a multifaceted educational intervention consisting of 60-min educational sessions, the distribution of slide kits and pocket guides with the recommendations, and an interactive virtual case presented at a teleconference and available for online consultation. A total of 74 Spanish hospitals. Specialists of the Intensive Care Units in the participating hospitals. Specialist knowledge and reported practices evaluated using a survey. The McNemar test was used to compare the responses in the pre- and post-intervention surveys. A total of 255 and 248 specialists completed both surveys, in both periods, respectively. The pre-intervention surveys showed many specialists to be unaware of the best approach for managing invasive candidiasis. After both educational interventions, specialist knowledge and reported practices were found to be more in line with nearly all the recommendations of the Epico 1 and Epico 2.0 guidelines, except as regards de-escalation from echinocandins to fluconazole in Candida glabrata infections (p=0.055), and the duration of antifungal treatment in both candidemia and peritoneal candidiasis. This multifaceted educational intervention based on the Epico Project recommendations improved specialist knowledge of the management of invasive candidiasis in critically ill patients. Copyright © 2016 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  17. MITA/STING: a central and multifaceted mediator in innate immune response.

    Science.gov (United States)

    Ran, Yong; Shu, Hong-Bing; Wang, Yan-Yi

    2014-12-01

    The recognition of nucleic acids is a general strategy used by the host to detect invading pathogens. Many studies have established that MITA/STING is a central component in the innate immune response to cytosolic DNA and RNA derived from pathogens. MITA can act both as a direct sensor of cyclic dinucleotides (CDNs) and as an adaptor for the recruitment of downstream signaling components. In both roles, MITA is part of signaling cascades that orchestrate innate immune defenses against various pathogens, including viruses, bacteria and parasites. Here, we highlight recent studies that have uncovered the molecular mechanisms of MITA-mediated signal transduction and regulation, and discuss some notable issues that remain elusive.

  18. Defense Science Board Task Force Report on Cyber Defense Management

    Science.gov (United States)

    2016-09-01

    posturethrough the CCMDs with measurement feedback to the leadership. The DoD CIO should establishmetrics for this assessment. Include Cyber Preparedness in...DoD should evaluate the effectiveness of the resulting defense posturethrough the CCMDs with measurement feedback to the leadership. The DoD CIO...USCYBERCOM Welcome Maj Keffer, USCYBERCOM Chief of Staff Cyber Portfolio Management Decisions Mr. Terry Carter, Deputy Director, Capabilities and Resource

  19. Impact of a multifaceted program to prevent postoperative delirium in the elderly: the CONFUCIUS stepped wedge protocol

    Directory of Open Access Journals (Sweden)

    Bonnefoy Marc

    2011-05-01

    Full Text Available Abstract Background Postoperative delirium is common in the elderly and is associated with a significant increase in mortality, complications, length of hospital stay and admission in long care facility. Although several interventions have proved their effectiveness to prevent it, the Cochrane advises an assessment of multifaceted intervention using rigorous methodology based on randomized study design. Our purpose is to present the methodology and expected results of the CONFUCIUS trial, which aims to measure the impact of a multifaceted program on the prevention of postoperative delirium in elderly. Method/Design Study design is a stepped wedge cluster randomized trial within 3 surgical wards of three French university hospitals. All patients aged 75 and older, and admitted for scheduled surgery will be included. The multifaceted program will be conducted by mobile geriatric team, including geriatric preoperative consultation, training of the surgical staff and implementation of the Hospital Elder Life Program, and morbidity and mortality conference related to delirium cases. The primary outcome is based on postoperative delirium rate within 7 days after surgery. This program is planned to be implemented along four successive time periods within all the surgical wards. Each one will be affected successively to the control arm and to the intervention arm of the trial and the order of program introduction within each surgical ward will be randomly assigned. Based on a 20% reduction of postoperative delirium rate (ICC = 0.25, α = 0.05, β = 0.1, three hundred sixty patients will be included i.e. thirty patients per service and per time period. Endpoints comparison between intervention and control arms of the trial will be performed by considering the cluster and time effects. Discussion Better prevention of delirium is expected from the multifaceted program, including a decrease of postoperative delirium, and its consequences (mortality

  20. From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

    OpenAIRE

    Yalcin, Ozlem; Oronsky, Bryan; Carvalho, Leonardo J. M.; Kuypers, Frans A; Scicinski, Jan; Cabrales, Pedro

    2015-01-01

    RESEARCH Open Access From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria Ozlem Yalcin1,2, Bryan Oronsky3, Leonardo J. M. Carvalho4,5, Frans A. Kuypers6, Jan Scicinski3 and Pedro Cabrales1* Abstract Background: The survival of malaria parasites, under substantial haem-induced oxidative stress in the red blood cells (RBCs) is dependent on the pentose phosphate pathway (PPP). The PPP is the only source of NADPH in the RBC, ess...

  1. Homeland Defense: DOD Needs to Address Gaps in Homeland Defense and Civil Support Guidance

    Science.gov (United States)

    2012-10-01

    tornado, storm, high water , wind-driven water , tidal wave, tsunami, earthquake, volcanic eruption , landslide, mudslide, snowstorm, or drought), or...Secretary of Defense and the Office of the Under Secretary of Defense for Policy on homeland defense and civil support matters, among other things. The...Assistant Secretary of Defense for Global Strategic Affairs is the principal advisor to the Under Secretary of Defense for Policy and the Secretary

  2. Austere Defense: Challenges and Opportunities

    Science.gov (United States)

    2014-01-01

    military advice while acquiescing to divestitures, and effectively executing the austere defense cuts required by current law through 2019 and...Could it be that our assessments of risk have, over time, become too conservative? In- deed, even with the effects of full sequestration the United... crunch . Look- ing at overhead, as Douglas Macgregor of Politico magazine reminds us, during World War II, only four four-star generals commanded a

  3. Western Hemisphere Defense Policy Statement

    Science.gov (United States)

    2012-10-01

    El Salvador, Guatemala, Honduras , Paraguay, Peru and Uruguay have contributed to or led multi-national security operations and United Nations (UN...impact on regional and global peace and security and reflect the new realities of defense cooperation in the hemisphere. Working with Canada and...Mexico, DoD remains prepared to deter and defeat direct threats to our homeland. We partner with Canada on regional security issues such as an evolving

  4. Application of Defense Technology Commonly Used in Boxing Match

    Institute of Scientific and Technical Information of China (English)

    Zhixiao Li[1; Jianjun Liu[2

    2015-01-01

    Boxing defense technology is a kind of techniques to prevent the opponent from attacking successfully. Boxing is a kind of sports that needs close cooperation between attack and defense. Attack is used for defense, where there is no attack, there will be no defense, and vice versa. Defense technology is the foundation of attack technology, therefore, defense is of vital importance in boxing match.

  5. CSRF Vulnerabilities and Defensive Techniques

    Directory of Open Access Journals (Sweden)

    Rupali D. Kombade

    2012-02-01

    Full Text Available Web applications are now part of day to day life due to their user friendly environment as well as advancement of technology to provide internet facilities, but these web applications brought lot of threats with them and these threats are continuously growing, one of the these threat is Cross Site Request Forgery(CSRF. CSRF attack is immerged as serious threat to web applications which based on the vulnerabilities present in the normal request response pattern of HTTP protocol. It is difficult to detect and hence it is present in most of the existing web applications. CSRF attack occurs when a malicious web site causes a user’s web browser to perform an unwanted action on a trusted site. It is listed in OWASP’s top ten Web Application attacks list. In this survey paper we will study CSRF attack, CSRF vulnerabilities and its defensive measures. We have compared various defense mechanisms to analyse the best defense mechanism. This study will help us to build strong and robust CSRF protection mechanism.

  6. Nicotine's defensive function in nature.

    Directory of Open Access Journals (Sweden)

    Anke Steppuhn

    2004-08-01

    Full Text Available Plants produce metabolites that directly decrease herbivore performance, and as a consequence, herbivores are selected for resistance to these metabolites. To determine whether these metabolites actually function as defenses requires measuring the performance of plants that are altered only in the production of a certain metabolite. To date, the defensive value of most plant resistance traits has not been demonstrated in nature. We transformed native tobacco(Nicotiana attenuata with a consensus fragment of its two putrescine N-methyl transferase (pmt genes in either antisense or inverted-repeat (IRpmt orientations. Only the latter reduced (by greater than 95% constitutive and inducible nicotine. With D(4-nicotinic acid (NA, we demonstrate that silencing pmt inhibits nicotine production, while the excess NA dimerizes to form anatabine. Larvae of the nicotine-adapted herbivore Manduca sexta (tobacco hornworm grew faster and, like the beetle Diabrotica undecimpunctata, preferred IRpmt plants in choice tests. When planted in their native habitat, IRpmt plants were attacked more frequently and, compared to wild-type plants, lost 3-fold more leaf area from a variety of native herbivores, of which the beet armyworm, Spodoptera exigua, and Trimerotropis spp. grasshoppers caused the most damage. These results provide strong evidence that nicotine functions as an efficient defense in nature and highlights the value of transgenic techniques for ecological research.

  7. Priming of antiherbivore defensive responses in plants

    Institute of Scientific and Technical Information of China (English)

    Jinwon Kim; Gary W.Felton

    2013-01-01

    Defense priming is defined as increased readiness of defense induction.A growing body of literature indicates that plants (or intact parts of a plant) are primed in anticipation of impending environmental stresses,both biotic and abiotic,and upon the following stimulus,induce defenses more quickly and strongly.For instance,some plants previously exposed to herbivore-inducible plant volatiles (HIPVs) from neighboring plants under herbivore attack show faster or stronger defense activation and enhanced insect resistance when challenged with secondary insect feeding.Research on priming of antiherbivore defense has been limited to the HIPV-mediated mechanism until recently,but significant advances were made in the past three years,including non-HIPV-mediated defense priming,epigenetic modifications as the molecular mechanism of priming,and others.It is timely to consider the advances in research on defense priming in the plantinsect interactions.

  8. Computational Investigation of the Thermochemistry and Kinetics of Steam Methane Reforming Over a Multi-Faceted Nickel Catalyst

    KAUST Repository

    Blaylock, D. Wayne

    2011-08-20

    A microkinetic model of steam methane reforming over a multi-faceted nickel surface using planewave, periodic boundary condition density functional theory is presented. The multi-faceted model consists of a Ni(111) surface, a Ni(100) surface, and nickel step edge sites that are modeled as a Ni(211) surface. Flux and sensitivity analysis are combined to gain an increased understanding of the important reactions, intermediates, and surface facets in SMR. Statistical thermodynamics are applied to allow for the investigation of SMR under industrially-relevant conditions (e.g., temperatures in excess of 500 °C and pressures in excess of 1 bar). The most important surface reactions are found to occur at the under-coordinated step edge sites modeled using the Ni(211) surface as well as on the Ni(100) surface. The primary reforming pathway is predicted to be through C*+ O*→ CO*at high temperatures; however, hydrogen-mediated reactions such as C*+ OH*→ COH*and C.H.*+ O*→ CHO*are predicted to become more important at low temperatures. The rate-limiting reactions are predicted to be dissociative chemisorption of methane in addition to the aforementioned C-O addition reactions. © 2011 Springer Science+Business Media, LLC.

  9. Long-term effectiveness of a multifaceted intervention on pain management in a walk-in clinic.

    Science.gov (United States)

    Junod Perron, N; Piguet, V; Bovier, P A

    2007-04-01

    Pain is a common complaint of patients attending walk-in clinics, but timely and appropriate pain management is often lacking. To evaluate the impact of a multifaceted intervention on pain management. Prospective interventional study. Three cross-sectional surveys were conducted: before, 4 months after and 14 months after a multifaceted intervention at the medical walk-in clinic of a university hospital. The intervention included both educational activities and structural changes. Use of recommended pain management procedures, pain relief and overall assessments of pain treatment and health professionals' attitudes were assessed using patient questionnaires, collected by mail. History of pain, records of pain intensity and use of pain medication were extracted from medical files. We analysed 1409 medical files and 695 questionnaires of patients presenting with pain. Documentation of pain intensity and administration of pain medication at the walk-in clinic improved significantly 14 months after the intervention (7% vs. 53% and 17% vs. 27%, respectively, ppain medication was more often administered by the oral route (14% vs. 23%, ppain relief (40% vs. 39%, p=0.92) or patients' overall assessments of pain management. The intervention improved adherence to recommended procedures, even in the longer term, but did not result in better patient outcomes. Continuing efforts are needed to help health professionals improve pain management in out-patient care.

  10. Effectiveness of a multifaceted intervention on improving thehand-washing skills and behaviors of migrant workers in Beijing.

    Science.gov (United States)

    Yang, Chong; Hu, Junfeng; Tao, Maoxuan; Li, Yubo; Chai, Yan; Ning, Yan; Li, Li; Xiao, Qin

    2016-05-09

    This study explores the effectiveness of a multifaceted intervention featuring a combination of tailored print and video (TPV) and peer education on improving the hand-washing skills and behaviors of migrant workers in the capital city of China. In the control group, supportive measures in both policy and environment were adopted. In addition, the intervention group received TPV and peer education. A total of 1496 participants were involved in the baseline and evaluation survey. The results showed that the participants experienced significant changes in developing health behaviors and skills as a whole after the intervention. The intervention effectiveness of hand-washing skills on vendors was relatively small compared with those on restaurant waiters and waitresses (44.3% and 87.2%, respectively). About 81.2 percent of the participants always forgot to carefully wash their thumbs and 81.8 percent failed to properly clean the back of their hands. The multifaceted intervention of this study has helped in improving the hand-washing skills and behaviors of migrant workers. Key steps should be strengthened to enhance the intervention effect. Moreover, the elderly should be given more attention with regards to hand-washing skills.

  11. In tepid defense of population health: physicians and antibiotic resistance.

    Science.gov (United States)

    Saver, Richard S

    2008-01-01

    Antibiotic resistance menaces the population as a dire public health threat and costly social problem. Recent proposals to combat antibiotic resistance focus to a large degree on supply side approaches. Suggestions include tinkering with patent rights so that pharmaceutical companies have greater incentives to discover novel antibiotics as well as to resist overselling their newer drugs already on market. This Article argues that a primarily supply side emphasis unfortunately detracts attention from physicians' important demand side influences. Physicians have a vital and unavoidably necessary role to play in ensuring socially optimal access to antibiotics. Dismayingly, physicians' management of the antibiotic supply has been poor and their defense of population health tepid at best. Acting as a prudent steward of the antibiotic supply often seems to be at odds with a physician's commonly understood fiduciary duties, ethical obligations, and professional norms, all of which traditionally emphasize the individual health paradigm as opposed to population health responsibilities. Meanwhile, physicians face limited incentives for antibiotic conservation from other sources, such as malpractice liability, regulatory standards, and reimbursement systems. While multifaceted efforts are needed to combat antibiotic resistance effectively, physician gatekeeping behavior should become a priority area of focus. This Article considers how health law and policy tools could favorably change the incentives physicians face for antibiotic conservation. A clear lesson from the managed care reform battles of the recent past is that interventions, to have the best chance of success, need to respect physician interest in clinical autonomy and individualized medicine even if, somewhat paradoxically, vigorously promoting population health perspectives. Also, physicians' legal and ethical obligations need to be reconceptualized in the antibiotic context in order to better support

  12. Defensive weapons and defense signals in plants: some metabolites serve both roles.

    Science.gov (United States)

    Maag, Daniel; Erb, Matthias; Köllner, Tobias G; Gershenzon, Jonathan

    2015-02-01

    The defense of plants against herbivores and pathogens involves the participation of an enormous range of different metabolites, some of which act directly as defensive weapons against enemies (toxins or deterrents) and some of which act as components of the complex internal signaling network that insures that defense is timed to enemy attack. Recent work reveals a surprising trend: The same compounds may act as both weapons and signals of defense. For example, two groups of well-studied defensive weapons, glucosinolates and benzoxazinoids, trigger the accumulation of the protective polysaccharide callose as a barrier against aphids and pathogens. In the other direction, several hormones acting in defense signaling (and their precursors and products) exhibit activity as weapons against pathogens. Knowing which compounds are defensive weapons, which are defensive signals and which are both is vital for understanding the functioning of plant defense systems. © 2015 WILEY Periodicals, Inc.

  13. Just in time: circadian defense patterns and the optimal defense hypothesis.

    Science.gov (United States)

    Baldwin, Ian T; Meldau, Stefan

    2013-06-01

    The optimal defense hypothesis (ODH) provides a functional explanation for the inhomogeneous distribution of defensive structures and defense metabolites throughout a plant's body: tissues that are most valuable in terms of fitness and have the highest probability of attack are generally the best defended. In a previous review, we argue that ontogenically-controlled accumulations of defense metabolites are likely regulated through an integration of developmental and defense signaling pathways. In this addendum, we extend the discussion of ODH patterns by including the recent discoveries of circadian clock-controlled defenses in plants.

  14. Cyber Defense: An International View

    Science.gov (United States)

    2015-09-01

    Protection), available from www.gesetze-im-internet.de/gg/art_65a. html, accessed on July 30, 2014. 36. Christian Kahl, Nachrichten, Vom Kampf in der...www.bundeswehr-journal.de/2013/vom- kampf -in-der-funften- dimension/, accessed on July 30, 2014; “Digitaler Truppenein- satz: Bundeswehr meldet sich...www.bundeswehr-journal. de/2013/vom- kampf -in-der-funften-dimension/. 46. “Spionage- und Hackerabwehr: Bundeswehr baut geheime Cy- berwar-Truppe auf” (“Defense of

  15. Territorial Defense, Education, and Interculturalism

    Directory of Open Access Journals (Sweden)

    Claudia Patricia Sierra Pardo

    2011-10-01

    Full Text Available The article carries out a series of reflections regarding the social and economic conditions in which the cultivation of oil palm affected the Bajo Atrato region of the Department of Chocó at the end of the nineteen nineties. It also discusses the actions carried out by communities, companies, and organizations in solidarity with the region’s cause, since these expressions make it possible to understand the role of organization and education in territorial defense processes. Finally, the article examines the different tensions, struggles, challenges, and contradictions inherent to these types of processes.

  16. Cyber defense and situational awareness

    CERN Document Server

    Kott, Alexander; Erbacher, Robert F

    2015-01-01

    This book is the first publication to give a comprehensive, structured treatment to the important topic of situational awareness in cyber defense. It presents the subject in a logical, consistent, continuous discourse, covering key topics such as formation of cyber situational awareness, visualization and human factors, automated learning and inference, use of ontologies and metrics, predicting and assessing impact of cyber attacks, and achieving resilience of cyber and physical mission. Chapters include case studies, recent research results and practical insights described specifically for th

  17. Department of Defense Expenditure Plans

    Science.gov (United States)

    2009-03-20

    Buxton Rd. 1,879 E 88 Redstone Arsenal AL Replace Water Main Along Paton Rd. from H.U. to Martin Rd. 1,857 E 89 Redstone Arsenal AL Fy 2009 Annual Road... Buxton Road E. from Patton to H.U. 1,312 E 25 American Recovery and Reinvestment Act of 2009 Operation and Maintenance, Defense Health Program, and...Meet AR 190-11 75 O 1100 Billings AFRC MT Mechanical System Improvements 188 E 1101 Billings AFRC MT Install Lighting Controls 45 E 1102 Billings

  18. SQL Injection Attacks and Defense

    CERN Document Server

    Clarke, Justin

    2012-01-01

    SQL Injection Attacks and Defense, First Edition: Winner of the Best Book Bejtlich Read Award "SQL injection is probably the number one problem for any server-side application, and this book unequaled in its coverage." -Richard Bejtlich, Tao Security blog SQL injection represents one of the most dangerous and well-known, yet misunderstood, security vulnerabilities on the Internet, largely because there is no central repository of information available for penetration testers, IT security consultants and practitioners, and web/software developers to turn to for help. SQL Injection Att

  19. The Fate of the World is in your hands: computer gaming for multi-faceted climate change education

    Science.gov (United States)

    Bedford, D. P.

    2015-12-01

    Climate change is a multi-faceted (or 'wicked') problem. True climate literacy therefore requires understanding not only the workings of the climate system, but also the current and potential future impacts of climate change and sea level rise on individuals, communities and countries around the world, as noted in the US Global Change Research Program's (2009) Climate Literacy: The Essential Principles of Climate Sciences. The asymmetric nature of climate change impacts, whereby the world's poorest countries have done the least to cause the problem but will suffer disproportionate consequences, has also been widely noted. Education in climate literacy therefore requires an element of ethics in addition to physical and social sciences. As if addressing these multiple aspects of climate change were not challenging enough, polling data has repeatedly shown that many members of the public tend to see climate change as a far away problem affecting people remote from them at a point in the future, but not themselves. This perspective is likely shared by many students. Computer gaming provides a possible solution to the combined problems of, on the one hand, addressing the multi-faceted nature of climate change, and, on the other hand, making the issue real to students. Fate of the World, a game produced by the company Red Redemption, has been used on several occasions in a small (20-30 students) introductory level general education course on global warming at Weber State University. Players are required to balance difficult decisions about energy investment while managing regional political disputes and attempting to maintain minimum levels of development in the world's poorer countries. By providing a realistic "total immersion" experience, the game has the potential to make climate change issues more immediate to players, and presents them with the ethical dilemmas inherent in climate change. This presentation reports on the use of Fate of the World in an educational

  20. Secure and defensive high self-esteem.

    Science.gov (United States)

    Jordan, Christian H; Spencer, Steven J; Zanna, Mark P; Hoshino-Browne, Etsuko; Correll, Joshua

    2003-11-01

    Long-standing theories have suggested high self-esteem (SE) can assume qualitatively different forms that are related to defensiveness. The authors explored whether some high-SE individuals are particularly defensive because they harbor negative self-feelings at less conscious levels, indicated by low implicit SE. In Study 1, participants high in explicit SE but low in implicit SE showed the highest levels of narcissism--an indicator of defensiveness. In Studies 2 and 3, the correspondence between implicit and explicit SE predicted defensive behavior (in-group bias in Study 2 and dissonance reduction in Study 3), such that for high explicit-SE participants, those with relatively low implicit SE behaved more defensively. These results are consistent with the idea that high SE can be relatively secure or defensive.

  1. The methodological defense of realism scrutinized.

    Science.gov (United States)

    Wray, K Brad

    2015-12-01

    I revisit an older defense of scientific realism, the methodological defense, a defense developed by both Popper and Feyerabend. The methodological defense of realism concerns the attitude of scientists, not philosophers of science. The methodological defense is as follows: a commitment to realism leads scientists to pursue the truth, which in turn is apt to put them in a better position to get at the truth. In contrast, anti-realists lack the tenacity required to develop a theory to its fullest. As a consequence, they are less likely to get at the truth. My aim is to show that the methodological defense is flawed. I argue that a commitment to realism does not always benefit science, and that there is reason to believe that a research community with both realists and anti-realists in it may be better suited to advancing science. A case study of the Copernican Revolution in astronomy supports this claim.

  2. Korean Defense Industry: Threat or Ally?

    Science.gov (United States)

    1994-02-22

    framework for defense industrial cooperation with Korea . While Senator Dixon eventually dropped his opposition and the Korean Fighter Program is now...US defense firms to transfer technology to Korean firms, the US Government must recognize two realities: first, Korea will develop indigenous...serious Korean competition in the foreseeable future. 8 It does not appear that the Korea defense industry is poised to take away significant market

  3. Implementing an Integrated Network Defense Construct

    Science.gov (United States)

    2013-06-01

    to create an easily defendable avenue for ingress and egress. In medieval times, castles leveraged this principle. If an attacker was brazen enough...defense mirrors that of the physical world, its application has some significant drawbacks. Whereas the medieval castle defenders had the high ground...defenses. Logically an INDS can and should follow the same premise. 3. Integrated Air Defense To model an INDS after an IADS, it is necessary

  4. THE DEFENSE PLANNING SYSTEMS AND THEIR IMPLICATIONS

    Directory of Open Access Journals (Sweden)

    Laszlo STICZ

    2010-01-01

    Full Text Available Defense planning in the Alliance is a fundamental element of the arrangements which enable its member countries to enjoy the crucial political, military and resource advantages of collective defense and other common military efforts to enhance security and stability. In this respect, the aim of this paper is to outline the role of the Armed Forces and the specific processes aiming to achieve the ultimate goal of a nation regarding national security, with focus on defense planning and the PDPS.

  5. Integrated Air and Missile Defense (IAMD)

    Science.gov (United States)

    2013-12-01

    Base Year DAMIR - Defense Acquisition Management Information Retrieval Dev Est - Development Estimate DoD - Department of Defense DSN - Defense...Schedule Milestones SAR Baseline Dev Est Current APB Development Objective/Threshold Current Estimate MS B DEC 2009 DEC 2009 JUN...2010 DEC 2009 CDR AUG 2011 MAY 2012 MAY 2013 MAY 2012 MS C DEC 2014 JUN 2015 JUN 2016 AUG 2016 1 (Ch-1) IOT &E Start JAN 2016 MAR 2016 MAR 2017 OCT 2017

  6. Offset implementations for Turkey's International Defense Acquisitions

    OpenAIRE

    2008-01-01

    MBA Professional Report "Offsets" is the umbrella term for a broad range of industrial and commercial "compensatory" practices. Specifically, offset agreements in the defense environment are increasing globally as a percentage of exports. Developed countries with established defense industries use offsets to channel work or technology to their domestic defense companies. Countries with newly industrialized economies are utilizing both military and commercial related offsets that involv...

  7. SELF-DEFENSE IN KARABAKH CONFLICT?

    Directory of Open Access Journals (Sweden)

    Saeed Bagheri

    2015-01-01

    Full Text Available Use of force is one of the principles of international law which has been banned by the UN Charter and modern constitutions. However, since the enforcement of the UN Charter, self-defense has become the preferred excuse for states to justify their use of force. But applying self-defense requires some conditions. Immediacy is one of the important conditions of self-defense. Immediacy defined as the time span between armed attacks and reaction to it, is the main discourse. This condition requires self defense immediately after the armed conflict or during a rational time span since its occurance.In this respect, the emerging Karabakh Conflict between Armenia and Azerbaijan in the 1990s is important. After Armenia’s armed attacks, Azerbaijan has acted within the scope of legitimate self-defense. But in accordance with UN Security Council cease-fire resolution Azerbaijan has suspended its self-defense actions. However, today, still twenty percent of Azerbaijani territory is still under Armenian occupation. Accordingly, after a long time the validity of Azerbaijan’s right to legitimate self-defense is still subject to arguments.In this article, by comparing two different approaches (strict and board interpretation approaches on the temporal link between the measures of self-defense and the armed attacks (immediacy, the temporal link between the self-defense countermeasures of Azerbaijan and armed attacks by Armenia in Karabakh Conflict will be examined.

  8. An Empirical Investigation of Defense Interpretation Depth, Defensive Functioning, and Alliance Strength in Psychodynamic Psychotherapy.

    Science.gov (United States)

    Petraglia, Jonathan; Bhatia, Maneet; De Roten, Yves; Despland, Jean-Nicolas; Drapeau, Martin

    2015-01-01

    The present study examined the relationship between depth of defense interpretations by therapists, and patient defensive functioning, on the therapeutic alliance in a sample of 36 patients undergoing short-term dynamic psychotherapy. Defense interpretation depth was defined as the degree to which therapist interpretations contained information regarding the motivation for patient defenses and historical origins of the defensive processes (Greensen, 1967). Mean depth of interpretation was compared between sessions that were identified beforehand as either high-alliance or low-alliance sessions using the Helping Alliance Questionnaire (HAq-II: Luborsky et al., 1996). Results indicated that defensive functioning was correlated to defense interpretation depth in low-alliance sessions. Moreover, mean depth of interpretation was also higher in low-alliance sessions, pointing to the possible "destabilizing" effects that these interpretations may have on both defensive functioning and the therapeutic alliance. These results are discussed within the context of previous studies of therapeutic technique in dynamic psychotherapy.

  9. Defense mutualisms enhance plant diversification.

    Science.gov (United States)

    Weber, Marjorie G; Agrawal, Anurag A

    2014-11-18

    The ability of plants to form mutualistic relationships with animal defenders has long been suspected to influence their evolutionary success, both by decreasing extinction risk and by increasing opportunity for speciation through an expanded realized niche. Nonetheless, the hypothesis that defense mutualisms consistently enhance plant diversification across lineages has not been well tested due to a lack of phenotypic and phylogenetic information. Using a global analysis, we show that the >100 vascular plant families in which species have evolved extrafloral nectaries (EFNs), sugar-secreting organs that recruit arthropod mutualists, have twofold higher diversification rates than families that lack species with EFNs. Zooming in on six distantly related plant clades, trait-dependent diversification models confirmed the tendency for lineages with EFNs to display increased rates of diversification. These results were consistent across methodological approaches. Inference using reversible-jump Markov chain Monte Carlo (MCMC) to model the placement and number of rate shifts revealed that high net diversification rates in EFN clades were driven by an increased number of positive rate shifts following EFN evolution compared with sister clades, suggesting that EFNs may be indirect facilitators of diversification. Our replicated analysis indicates that defense mutualisms put lineages on a path toward increased diversification rates within and between clades, and is concordant with the hypothesis that mutualistic interactions with animals can have an impact on deep macroevolutionary patterns and enhance plant diversity.

  10. The insanity defense: Related issues

    Science.gov (United States)

    Asokan, T. V.

    2016-01-01

    For the past 150 years, there is no change in the understanding and knowledge other than autonomy and capacity to choose the right and wrong for criminal liability. The alternative concept that human behavior is the result of an interaction between biological and environmental factors other than free choice failed to impress the criminal justice system because of a direct threat to a society's deep seated need to blame someone than themselves for criminal harms that occur. The insanity defense has a long history, and is evolved after many tests that have been tried and tested. McNaughton's rules stressed on “understandability of right and wrong” and “intellectual” rather than a moral or affective definition dominated in its formulation. Lack of control and irresistible drives or impulses were neglected Going by the current understanding of neurological evidences of compulsion and lack of impulse control, rationality tests without the inclusion of lack of control, seem to be outdated. Separate “Control determination” than the “Rationality determination” by the jurors may improve the accuracy of Juror's categorizations. There is a suggestion that Relevance ratio is ideal for ‘Evidentiary relevance” and there should be a quality control on expert testimonies. With progress in neuroscience, the law may need to abandon or alter some of its current assumptions about the nature of voluntary conduct, which underlies various defenses PMID:28216769

  11. Defensive anality and anal narcissism.

    Science.gov (United States)

    Shengold, L

    1985-01-01

    This paper aims at demonstrating a currently beleaguered assumption: the central importance, the continuing vitality, and the appropriate complexity of Freud's theory of the drives and of his idea of the primacy of the body ego. It is not enough to consider man a thinking machine or a social being; his animal nature must be given a central place in psychology. The paper postulates that 'anal or sphincter defensiveness' is one of the precursors of the repression barrier. Anality has been comparatively neglected in recent psychoanalytic literature, and so has its explorer, Karl Abraham. The paper's thesis is that there is a special defensive importance to anal erogeneity and libido, and to those aspects of ego and superego that are functionally operative (as the 'sadistic-anal organization' (Freud, 1917)) during the so-called 'sadistic-anal' developmental phase. Any of the psychic danger situations can evoke regression to manifestations of 'anal narcissim'--an attempt to master overwhelming feeling by a kind of emotional sphincter action, narrowing down the world to the controllable and the predictable. The basic assumption here is Fliess's idea that the attainment of anal sphincter control functions--with, as-it-were, 'psychic resonance'--as a means to master primal (murderous, cannibalistic) affect. For optimal psychic development, a proper balance must be attained between anal control of, and anal expression of, instinctual derivatives--especially of affect laden with aggression.

  12. Nrf2 and cardiovascular defense.

    Science.gov (United States)

    Howden, Reuben

    2013-01-01

    The cardiovascular system is susceptible to a group of diseases that are responsible for a larger proportion of morbidity and mortality than any other disease. Many cardiovascular diseases are associated with a failure of defenses against oxidative stress-induced cellular damage and/or death, leading to organ dysfunction. The pleiotropic transcription factor, nuclear factor-erythroid (NF-E) 2-related factor 2 (Nrf2), regulates the expression of antioxidant enzymes and proteins through the antioxidant response element. Nrf2 is an important component in antioxidant defenses in cardiovascular diseases such as atherosclerosis, hypertension, and heart failure. Nrf2 is also involved in protection against oxidant stress during the processes of ischemia-reperfusion injury and aging. However, evidence suggests that Nrf2 activity does not always lead to a positive outcome and may accelerate the pathogenesis of some cardiovascular diseases (e.g., atherosclerosis). The precise conditions under which Nrf2 acts to attenuate or stimulate cardiovascular disease processes are unclear. Further studies on the cellular environments related to cardiovascular diseases that influence Nrf2 pathways are required before Nrf2 can be considered a therapeutic target for the treatment of cardiovascular diseases.

  13. Nrf2 and Cardiovascular Defense

    Directory of Open Access Journals (Sweden)

    Reuben Howden

    2013-01-01

    Full Text Available The cardiovascular system is susceptible to a group of diseases that are responsible for a larger proportion of morbidity and mortality than any other disease. Many cardiovascular diseases are associated with a failure of defenses against oxidative stress-induced cellular damage and/or death, leading to organ dysfunction. The pleiotropic transcription factor, nuclear factor-erythroid (NF-E 2-related factor 2 (Nrf2, regulates the expression of antioxidant enzymes and proteins through the antioxidant response element. Nrf2 is an important component in antioxidant defenses in cardiovascular diseases such as atherosclerosis, hypertension, and heart failure. Nrf2 is also involved in protection against oxidant stress during the processes of ischemia-reperfusion injury and aging. However, evidence suggests that Nrf2 activity does not always lead to a positive outcome and may accelerate the pathogenesis of some cardiovascular diseases (e.g., atherosclerosis. The precise conditions under which Nrf2 acts to attenuate or stimulate cardiovascular disease processes are unclear. Further studies on the cellular environments related to cardiovascular diseases that influence Nrf2 pathways are required before Nrf2 can be considered a therapeutic target for the treatment of cardiovascular diseases.

  14. Multifaceted Health Benefits of Mangifera indica L. (Mango): The Inestimable Value of Orchards Recently Planted in Sicilian Rural Areas.

    Science.gov (United States)

    Lauricella, Marianna; Emanuele, Sonia; Calvaruso, Giuseppe; Giuliano, Michela; D'Anneo, Antonella

    2017-05-20

    Historically, Mangifera indica L. cultivations have been widely planted in tropical areas of India, Africa, Asia, and Central America. However, at least 20 years ago its spreading allowed the development of some cultivars in Sicily, an island to the south of Italy, where the favourable subtropical climate and adapted soils represent the perfect field to create new sources of production for the Sicilian agricultural supply chain. Currently, cultivations of Kensington Pride, Keitt, Glenn, Maya, and Tommy Atkins varieties are active in Sicily and their products meet the requirements of local and European markets. Mango plants produce fleshy stone fruits rich in phytochemicals with an undisputed nutritional value for its high content of polyphenolics and vitamins. This review provides an overview of the antioxidant, anti-inflammatory, and anticancer properties of mango, a fruit that should be included in everyone's diet for its multifaceted biochemical actions and health-enhancing properties.

  15. A call for a multifaceted approach to language learning motivation research: Combining complexity, humanistic, and critical perspectives

    Directory of Open Access Journals (Sweden)

    Julian Pigott

    2012-10-01

    Full Text Available In this paper I give an overview of recent developments in the L2 motivation field, in particular the movement away from quantitative, questionnaire-based methodologies toward smaller-scale qualitative studies incorporating concepts from complexity theory. While complexity theory provides useful concepts for exploring motivation in new ways, it has nothing to say about ethics, morality, ideology, politics, power or educational purpose. Furthermore, calls for its use come primarily from researchers from the quantitative tradition whose aim in importing this paradigm from the physical sciences appears to be to conceptualize and model motivation more accurately. The endeavor therefore remains a fundamentally positivist one. Rather than being embraced as a self-contained methodology, I argue that complexity theory should be used cautiously and prudently alongside methods grounded in other philosophical traditions. Possibilities abound, but here I suggest one possible multifaceted approach combining complexity theory, a humanisticconception of motivation, and a critical perspective.

  16. Elusive silane-alane complex [Si-H⋅⋅⋅Al]: isolation, characterization, and multifaceted frustrated Lewis pair type catalysis.

    Science.gov (United States)

    Chen, Jiawei; Chen, Eugene Y-X

    2015-06-01

    The super acidity of the unsolvated Al(C6F5)3 enabled isolation of the elusive silane-alane complex [Si-H⋅⋅⋅Al], which was structurally characterized by spectroscopic and X-ray diffraction methods. The Janus-like nature of this adduct, coupled with strong silane activation, effects multifaceted frustrated-Lewis-pair-type catalysis. When compared with the silane-borane system, the silane-alane system offers unique features or clear advantages in the four types of catalytic transformations examined in this study, including: ligand redistribution of tertiary silanes into secondary and quaternary silanes, polymerization of conjugated polar alkenes, hydrosilylation of unactivated alkenes, and hydrodefluorination of fluoroalkanes.

  17. Adoption of workplaces and reach of employees for a multi-faceted intervention targeting low back pain among nurses' aides

    DEFF Research Database (Denmark)

    Rasmussen, Charlotte Diana Nørregaard; Larsen, Anne Konring; Holtermann, Andreas;

    2014-01-01

    eligible workplaces. From the adopted workplaces reach was calculated among eligible employees as the percentage who responded on a questionnaire. Responders were compared with non-responders using data from company registrations. Among responders, comparisons based on questionnaire data were performed......BACKGROUND: Workplace adoption and reach of health promotion are important, but generally poorly reported. The aim of this study is therefore to evaluate the adoption of workplaces (organizational level) and reach of employees (individual level) of a multi-faceted workplace health promotion...... between those consenting to participate in the intervention (consenters) and those not consenting to participate in the intervention (non-consenters). Comparisons were done using Student's t-test for the continuous variables, Fisher's exact test for dichotomous variables and the Pearson's chi(2...

  18. Concepts of multifaceted social support in operational work in the lives of South African Police Service members

    Directory of Open Access Journals (Sweden)

    Masefako A. Gumani

    2014-06-01

    Full Text Available Orientation: The extensive role that social support plays in the lives of South African Police Service (SAPS members outside of the expected work networks of professionals and colleagues should be further studied to reflect on the benefits received when handling the stressful and traumatic effects of operational work.Research purpose: The objective of this study was to describe the concepts of multifaceted social support network systems as perceived by SAPS members in the context of the Vhembe District (South Africa in assisting them to deal with the effects of their operational work.Motivation for the study: There is still a call in social research to focus on the influence of different functions and sources of social support.Research design, approach and method: A descriptive phenomenological research design was used, and 20 SAPS participants were selected through purposive sampling. Unstructured,face-to-face interviews, field notes, telephone follow-ups and diaries were used to collect data which was subsequently analysed through phenomenological explication.Main findings: The results show that social support is not a linear process but is multifaceted,depending on specific operational settings. Furthermore, the social support network system identified is informed by the values of communal living in the Vhembe District as well as in the operational context in which the SAPS members work.Practical/managerial implications: The SAPS should help initiate and involve, during the debriefing of operational members, types and functions of social support that are dependent on organisational and community contexts.Contribution/value-add: This study makes a meaningful contribution to understanding that social support in the SAPS operational context is different from other contexts.

  19. Defense Science Board Task Force on Defense Strategies for Advanced Ballistic and Cruise Missile Threats

    Science.gov (United States)

    2017-01-01

    REPORT OF THE DEFENSE SCIENCE BOARD TASK FORCE ON Defense Strategies for Advanced Ballistic and Cruise Missile Threats January 2017 Office of... Science Board (DSB). The DSB is a Federal Advisory Committee established to provide independent advice to the Secretary of Defense. Statements, opinions... Science Board Task Force on Defense Strategies for Advanced Ballistic and Cruise Missile Threats completed its information-gathering in February 2016

  20. Strategic Defense Initiative: Splendid Defense or Pipe Dream? Headline Series No. 275.

    Science.gov (United States)

    Armstrong, Scott; Grier, Peter

    This pamphlet presents a discussion of the various components of President Reagan's Strategic Defense Initiative (SDI) including the problem of pulling together various new technologies into an effective defensive system and the politics of the so-called "star wars" system. An important part of the defense initiative is the "layered" defense…

  1. 75 FR 65462 - Renewal of Department of Defense Federal Advisory Committee; Department of Defense Military...

    Science.gov (United States)

    2010-10-25

    ... Military Family Readiness Council AGENCY: Department of Defense (DoD). ACTION: Renewal of Federal advisory... Department of Defense Military Family Readiness Council (hereafter referred to as the ``Council''). FOR... military family readiness by the Department of Defense; and (c) evaluate and assess the effectiveness...

  2. 75 FR 3210 - Renewal of Department of Defense Federal Advisory Committee; Defense Business Board

    Science.gov (United States)

    2010-01-20

    ... sector corporations or entities and a wealth of top-level, global business experience in the areas of... of the Secretary Renewal of Department of Defense Federal Advisory Committee; Defense Business Board... gives notice that it is renewing the charter for the Defense Business Board (hereafter referred to...

  3. 75 FR 15695 - Renewal of Department of Defense Federal Advisory Committee; Board of Visitors National Defense...

    Science.gov (United States)

    2010-03-30

    ... Defense gives notice that it is renewing the charter for the Board of Visitors National Defense University (hereafter referred to as the Board). FOR FURTHER INFORMATION CONTACT: Jim Freeman, Deputy Committee... of the Secretary Renewal of Department of Defense Federal Advisory Committee; Board of...

  4. 75 FR 13093 - Renewal of Department of Defense Federal Advisory Committee; Defense Acquisition University Board...

    Science.gov (United States)

    2010-03-18

    ... University Board of Visitors AGENCY: Department of Defense (DoD). ACTION: Renewal of Federal advisory... amended), and 41 CFR 102-3.50(c), the Department of Defense gives notice that it is renewing the charter for the Defense Acquisition University Board of Visitors (hereafter referred to as the Board)....

  5. Effectiveness of a multifaceted implementation strategy on physicians' referral behavior to an evidence-based psychosocial intervention in dementia: a cluster randomized controlled trial

    NARCIS (Netherlands)

    Dopp, C.M.E.; Graff, M.J.L.; Teerenstra, S.; Sanden, M.W.; Olde Rikkert, M.G.M.; Vernooij-Dassen, M.J.F.J.

    2013-01-01

    BACKGROUND: To evaluate the effectiveness of a multifaceted implementation strategy on physicians' referral rate to and knowledge on the community occupational therapy in dementia program (COTiD program). METHODS: A cluster randomized controlled trial with 28 experimental and 17 control clusters was

  6. Hands4U : the effects of a multifaceted implementation strategy on hand eczema prevalence in a healthcare setting. Results of a randomized controlled trial

    NARCIS (Netherlands)

    van der Meer, Esther W. C.; Boot, Cecile R. L.; van der Gulden, Joost W. J.; Knol, Dirk L.; Jungbauer, Frank H. W.; Coenraads, Pieter Jan; Anema, Johannes R.

    2015-01-01

    Background. Healthcare workers have an increased risk of developing hand eczema. A multifaceted implementation strategy was developed to implement a guideline to prevent hand eczema among healthcare workers. Objectives. To investigate the effects of the implementation strategy on self-reported hand

  7. The construction of the Øresund link between Denmark and Sweden: the effect of a multi-faceted safety campaign

    DEFF Research Database (Denmark)

    Kines, Peter; Spangenberg, S.; Mikkelsen, K.L.;

    2002-01-01

    The purpose of the present study was to evaluate the effect of a safety campaign implemented midway during the construction of the railway and road link across the Sound, Oresund, between Denmark and Sweden. The safety campaign was multi-faceted and aimed both at promoting positive attitudes...

  8. Hands4U : the effects of a multifaceted implementation strategy on hand eczema prevalence in a healthcare setting. Results of a randomized controlled trial

    NARCIS (Netherlands)

    van der Meer, Esther W. C.; Boot, Cecile R. L.; van der Gulden, Joost W. J.; Knol, Dirk L.; Jungbauer, Frank H. W.; Coenraads, Pieter Jan; Anema, Johannes R.

    Background. Healthcare workers have an increased risk of developing hand eczema. A multifaceted implementation strategy was developed to implement a guideline to prevent hand eczema among healthcare workers. Objectives. To investigate the effects of the implementation strategy on self-reported hand

  9. Hands4U: the effectiveness of a multifaceted implementation strategy on behaviour related to the prevention of hand eczema-a randomised controlled trial among healthcare workers

    NARCIS (Netherlands)

    Meer, E.W. van der; Boot, C.R.L.; Twisk, J.W.R.; Coenraads, P.J.; Jungbauer, F.H.; Gulden, J.W.J. van der; Anema, J.R.

    2014-01-01

    OBJECTIVES: To investigate the effects of a multifaceted implementation strategy on behaviour, behavioural determinants, knowledge and awareness of healthcare workers regarding the use of recommendations to prevent hand eczema. METHODS: The Hands4U study is a randomised controlled trial. A total of

  10. Hands4U: the effects of a multifaceted implementation strategy on hand eczema prevalence in a healthcare setting. Results of a randomized controlled trial

    NARCIS (Netherlands)

    Meer, E.W. van der; Boot, C.R.; Gulden, J.W.J. van der; Knol, D.L.; Jungbauer, F.H.; Coenraads, P.J.; Anema, J.R.

    2015-01-01

    BACKGROUND: Healthcare workers have an increased risk of developing hand eczema. A multifaceted implementation strategy was developed to implement a guideline to prevent hand eczema among healthcare workers. OBJECTIVES: To investigate the effects of the implementation strategy on self-reported hand

  11. Hands4U : the effectiveness of a multifaceted implementation strategy on behaviour related to the prevention of hand eczema-a randomised controlled trial among healthcare workers

    NARCIS (Netherlands)

    van der Meer, Esther W. C.; Boot, Cecile R. L.; Twisk, Jos W. R.; Coenraads, Pieter Jan; Jungbauer, Frank H. W.; van der Gulden, Joost W. J.; Anema, Johannes R.

    Objectives To investigate the effects of a multifaceted implementation strategy on behaviour, behavioural determinants, knowledge and awareness of healthcare workers regarding the use of recommendations to prevent hand eczema. Methods The Hands4U study is a randomised controlled trial. A total of 48

  12. The effect of a multifaceted empowerment strategy on decision making about the number of embryos transferred in in vitro fertilisation: randomised controlled trial.

    NARCIS (Netherlands)

    Peperstraten, A.M. van; Nelen, W.L.D.M.; Grol, R.P.T.M.; Zielhuis, G.A.; Adang, E.M.M.; Stalmeier, P.F.M.; Hermens, R.P.M.G.; Kremer, J.A.M.

    2010-01-01

    OBJECTIVE: To evaluate the effects of a multifaceted empowerment strategy on the actual use of single embryo transfer after in vitro fertilisation. DESIGN: Randomised controlled trial. SETTING: Five in vitro fertilisation clinics in the Netherlands. PARTICIPANTS: 308 couples (women aged <40) on the

  13. Evaluation of implementation of the ParkFit program: A multifaceted intervention aimed to promote physical activity in patients with Parkinson's disease

    NARCIS (Netherlands)

    Speelman, A.D.; Nimwegen, M.L. van; Bloem, B.R.; Munneke, M.

    2014-01-01

    OBJECTIVES: We recently completed the ParkFit study, a two-year randomized controlled trial including 586 sedentary Parkinson's disease (PD) patients, that evaluated a multifaceted intervention (ParkFit program) to promote physical activity. The results showed that the ParkFit program enables PD pat

  14. A multifaceted feedback strategy alone does not improve the adherence to organizational guideline-based standards : A cluster randomized trial in intensive care

    NARCIS (Netherlands)

    de Vos, Maartje; van der Veer, S.N.; Wouterse, B.; Graafmans, W.C.; Peek, N.; de Keizer, N.F.; Jager, K.J.; Westert, Gert; van der Voort, P.H.J.

    2015-01-01

    Background Organizational data such as bed occupancy rate and nurse-to-patient ratio are related to clinical outcomes and to the efficient use of intensive care unit (ICU) resources. Standards for these performance indicators are provided in guidelines. We studied the effects of a multifaceted

  15. A multifaceted feedback strategy alone does not improve the adherence to organizational guideline-based standards: a cluster randomized trial in intensive care

    NARCIS (Netherlands)

    Vos, M.L. de; Veer, S.N. van der; Wouterse, B.; Graafmans, W.C.; Peek, N.; Keizer, N.F. de; Jager, K.J.; Westert, G.P.; Voort, P.H. van der

    2015-01-01

    BACKGROUND: Organizational data such as bed occupancy rate and nurse-to-patient ratio are related to clinical outcomes and to the efficient use of intensive care unit (ICU) resources. Standards for these performance indicators are provided in guidelines. We studied the effects of a multifaceted

  16. Risk Management Programs for Defense Acquisition Systems

    Science.gov (United States)

    2007-11-02

    The audit objective was to evaluate the effectiveness of risk management programs for Defense acquisition systems. Specifically, we determined whether DoD risk management policies and procedures for Defense acquisition systems were effectively implemented and what impact risk management programs bad on reducing program risks and costs. We also reviewed management controls as they applied to the audit objectives.

  17. Protecting the Self: Defense Mechanisms in Action

    Science.gov (United States)

    Cramer, Phebe

    2006-01-01

    Integrating theory, research, and practical applications, this book provides a comprehensive examination of defense mechanisms and their role in both normal development and psychopathology. The author describes how children and adults mobilize specific kinds of defenses to maintain their psychological equilibrium and preserve self-esteem,…

  18. U.S. Cybersecurity Defense Assessment

    Science.gov (United States)

    2013-03-01

    Computer Network Defense ( CND ) actions to include “protecting, monitoring, analyzing, detecting, and responding to unauthorized activity within...such as computer network defense ( CND ), computer network exploitation (CNE), and computer network attack (CNA).38 In this capacity, the institution

  19. Takedown Defenses of Russian Systema

    Directory of Open Access Journals (Sweden)

    Kevin R. Secours

    2012-07-01

    Full Text Available The continuing popularity of mixed martial arts (MMA events has motivated many martial artists to cross train in grappling disciplines. While largely beneficial for the arts as a whole, many practitioners have nevertheless integrated grappling strategies without considering whether or not their applications are simply sportive or appropriate for self-defense tactics. In this article, I will examine some historical perspectives on the role of grappling on the battlefield from published literature and consider the evidence left to us through historical texts and artwork. Based on over 20 years experience in the grappling arts, I will attempt to show that ground fighting and grappling are necessary components of a complete tactical arsenal, while carefully illustrating the difference in street tactics. I will place specific emphasis on the role of defending the takedown in a modern survival scenario, giving particular attention to the approach employed by the Russian art of Systema.

  20. Physics of a ballistic missile defense - The chemical laser boost-phase defense

    Science.gov (United States)

    Grabbe, Crockett L.

    1988-01-01

    The basic physics involved in proposals to use a chemical laser based on satellites for a boost-phase defense are investigated. After a brief consideration of simple physical conditions for the defense, a calculation of an equation for the number of satellites needed for the defense is made along with some typical values of this for possible future conditions for the defense. Basic energy and power requirements for the defense are determined. A sumary is made of probable minimum conditions that must be achieved for laser power, targeting accuracy, number of satellites, and total sources for power needed.

  1. Defensive externality and blame projection following failure.

    Science.gov (United States)

    Hochreich, D J

    1975-09-01

    This study focuses upon the relationship between internal-external control and defensive blame projection. Trust was used as a moderator variable for making differential predictions concerning the behavior of two subgroups of externals: defensive externals, whose externality is presumed to reflect primarily a verbal technique of defense, and congruent externals, whose externality reflects a more genuine belief that most outcomes are determined by forces beyond their personal control. As predicted, defensive externals showed a stronger tendency than did congruent externals and internals to resort to blame projection following failure at an achievement task. There were no group differences in attribution following task success. Defensive externals were found to be more responsive to negative feedback than were congruent externals.

  2. Primitive defenses: cognitive aspects and therapeutic handling.

    Science.gov (United States)

    Groh, L S

    In this paper the primitive defenses first described by Melanie Klein under the label of "schizoid mechanisms" are examined. The defenses considered are splitting the pathological uses of identification and projective identification, and the psychotic forms of denial. This examination is twofold: (1) the cognitive aspects of these defenses as described in terms of concepts developed by Jean Piaget; (2) concrete examples of the operation of these defenses during the treatment of schizophrenic patients are given and the effects of interventions based on the cognitive analysis are described. It is stressed that at times interventions, such as interpretation and confrontation, based on cognitive analysis, can temporarily and in some instances even permanently stop the operation of these defenses, allowing emotionally meaningful material to emerge which expedites the therapeutic process.

  3. Immune defense in leaf-cutting ants

    DEFF Research Database (Denmark)

    Armitage, Sophie A O; Broch, Jens F; Marín, Hermogenes Fernández

    2011-01-01

    To ameliorate the impact of disease, social insects combine individual innate immune defenses with collective social defenses. This implies that there are different levels of selection acting on investment in immunity, each with their own trade-offs. We present the results of a cross...... both individual innate immunity (constitutive antibacterial activity) and the size of the metapleural gland, which secretes antimicrobial compounds and functions in individual and social defense, indicating multiple mating could have important consequences for both defense types. However, the primarily...... for this pattern would be co-adaptation between host colonies and their vertically transmitted mutualist. These results illustrate the complexity of the selection pressures that affect the expression of multilevel immune defenses....

  4. Defense Science Board Summer Study on Autonomy

    Science.gov (United States)

    2016-06-01

    Autonomy completed  its information gathering in August 2015. The report was cleared for open  publication by the DoD Office of  Security  Review on June 1...operation  CRASH  Clean‐Slate Design of Resilient, Adaptive,  Secure  Hosts  DARPA  Defense Advanced Research and Projects Agency  DCA  defensive counter air...DIA  Defense Intelligence Agency  DISA  Defense Information Systems Agency  DLA  Defense Logistics Agency  DNS   domain name service  DoD  Department

  5. Optimal defense strategy: storage vs. new production.

    Science.gov (United States)

    Shudo, Emi; Iwasa, Yoh

    2002-12-07

    If hosts produce defense proteins after they are infected by pathogens, it may take hours to days before defense becomes fully active. By producing defense proteins beforehand, and storing them until infection, the host can cope with pathogens with a short time delay. However, producing and storing defense proteins require energy, and the activated defense proteins often cause harm to the host's body as well as to pathogens. Here, we study the optimal strategy for a host who chooses the amount of stored defense proteins, the activation of the stored proteins upon infection, and the new production of the proteins. The optimal strategy is the one that minimizes the sum of the harm by pathogens and the cost of defense. The host chooses the storage size of defense proteins based on the probability distribution of the magnitude of pathogen infection. When the infection size is predictable, all the stored proteins are to be activated upon infection. The optimal strategy is to have no storage and to rely entirely on new production if the expected infection size n(0) is small, but to have a big storage without new production if n(0) is large. The transition from the "new production" phase to "storage" phase occurs at a smaller n(0) when storage cost is small, activation cost is large, pathogen toxicity is large, pathogen growth is fast, the defense is effective, the delay is long, and the infection is more likely. On the other hand, the storage size to produce for a large n(0) decreases with three cost parameters and the defense effectiveness, increases with the likelihood of infection, the toxicity and the growth rate of pathogens, and it is independent of the time delay. When infection size is much smaller than the expected size, some of the stored proteins may stay unused.

  6. Investment in defense and cost of predator-induced defense along a resource gradient

    DEFF Research Database (Denmark)

    Steiner, Uli

    2007-01-01

    An organism's investment in different traits to reduce predation is determined by the fitness benefit of the defense relative to the fitness costs associated with the allocation of time and resources to the defense. Inherent tradeoffs in time and resource allocation should result in differential...... investment in defense along a resource gradient, but competing models predict different patterns of investment. There are currently insufficient empirical data on changes in investment in defensive traits or their costs along resource gradients to differentiate between the competing allocation models....... In this study, I exposed tadpoles to caged predators along a resource gradient in order to estimate investment in defense and costs of defense by assessing predator-induced plasticity. Induced defenses included increased tail depth, reduced feeding, and reduced swimming activity; costs associated...

  7. MEVA--An Interactive Visualization Application for Validation of Multifaceted Meteorological Data with Multiple 3D Devices.

    Directory of Open Access Journals (Sweden)

    Carolin Helbig

    Full Text Available To achieve more realistic simulations, meteorologists develop and use models with increasing spatial and temporal resolution. The analyzing, comparing, and visualizing of resulting simulations becomes more and more challenging due to the growing amounts and multifaceted character of the data. Various data sources, numerous variables and multiple simulations lead to a complex database. Although a variety of software exists suited for the visualization of meteorological data, none of them fulfills all of the typical domain-specific requirements: support for quasi-standard data formats and different grid types, standard visualization techniques for scalar and vector data, visualization of the context (e.g., topography and other static data, support for multiple presentation devices used in modern sciences (e.g., virtual reality, a user-friendly interface, and suitability for cooperative work.Instead of attempting to develop yet another new visualization system to fulfill all possible needs in this application domain, our approach is to provide a flexible workflow that combines different existing state-of-the-art visualization software components in order to hide the complexity of 3D data visualization tools from the end user. To complete the workflow and to enable the domain scientists to interactively visualize their data without advanced skills in 3D visualization systems, we developed a lightweight custom visualization application (MEVA - multifaceted environmental data visualization application that supports the most relevant visualization and interaction techniques and can be easily deployed. Specifically, our workflow combines a variety of different data abstraction methods provided by a state-of-the-art 3D visualization application with the interaction and presentation features of a computer-games engine. Our customized application includes solutions for the analysis of multirun data, specifically with respect to data uncertainty and

  8. Implementing targeted expectant management in fertility care using prognostic modelling: a cluster randomized trial with a multifaceted strategy.

    Science.gov (United States)

    Kersten, F A M; Nelen, W L D M; van den Boogaard, N M; van Rumste, M M; Koks, C A; IntHout, J; Verhoeve, H R; Pelinck, M J; Boks, D E S; Gianotten, J; Broekmans, F J M; Goddijn, M; Braat, D D M; Mol, B W J; Hermens, R P G M

    2017-08-01

    What is the effectiveness of a multifaceted implementation strategy compared to usual care on improving the adherence to guideline recommendations on expectant management for couples with unexplained infertility? The multifaceted implementation strategy did not significantly increase adherence to guideline recommendations on expectant management compared to care as usual. Intrauterine insemination (IUI) with or without ovarian hyperstimulation has no beneficial effect compared to no treatment for 6 months after the fertility work-up for couples with unexplained infertility and a good prognosis of natural conception. Therefore, various professionals and policy makers have advocated the use of prognostic profiles and expectant management in guideline recommendations. A cluster randomized controlled trial in 25 clinics in the Netherlands was conducted between March 2013 and May 2014. Clinics were randomized between the implementation strategy (intervention, n = 13) and care as usual (control, n = 12). The effect of the implementation strategy was evaluated by comparing baseline and effect measurement data. Data collection was retrospective and obtained from medical record research and a patient questionnaire. A total of 544 couples were included at baseline and 485 at the effect measurement (247 intervention group/238 control group). Guideline adherence increased from 49 to 69% (OR 2.66; 95% CI 1.45-4.89) in the intervention group, and from 49 to 61% (OR 2.03; 95% CI 1.38-3.00) in the control group. Multilevel analysis with case-mix adjustment showed that the difference of 8% was not statistically significant (OR 1.31; 95% CI 0.67-2.59). The ongoing pregnancy rate within six months after fertility work-up did not significantly differ between intervention and control group (25% versus 27%: OR 0.72; 95% CI 0.40-1.27). There is a possible selection bias, couples included in the study had a higher socio-economic status than non-responders. How this affects guideline

  9. Defense Innovation and Industrialization in South Korea

    OpenAIRE

    Moon, Chung-in; Paek, Jae-Ok

    2010-01-01

    South Korea’s defense industrial transformation has been impressive by any standard. It was able to satisfy most of its basic weapons needs within a decade after launching its defense industry. Since the late 1990s, South Korea has been elevated from a third-tier arms producer to the second tier by moving from the stage of imitation and assembly to that of creative imitation and indigenization. It now competes with major arms-supplying countries. In addition, the South Korean defense...

  10. Strategies for Dealing with the Defense Budget

    Science.gov (United States)

    1983-08-17

    UNCLASSIFIED ItCUWIfV CUAWICATIOH O^ T>"» *»C« C.»lt— Omm gnt REPORT D0ajM6NTATI0N PAGE READ rNSTRUCTIO.NS OSFOPC COMWLETTNG FORM DSSW BOA ...documentation. \\ STRATEGIES FOR DEALING WITH THE DEFENSE BUDGET for Defense Systems Management College DSSW BOA No. MDA 903-82-G-0047 BOOZ ALLEN...Frisch, Franz A. and Acker, David D., "Financing Defense System Programs," Concepts (J. Def. Sys. Acq. Mgmt.), Vol. 4, No. 4, Autumn 1981, pp. 7

  11. Growth optimization and characterization of GaN epilayers on multifaceted (111) surfaces etched on Si(100) substrates

    Energy Technology Data Exchange (ETDEWEB)

    Ansah-Antwi, KwaDwo Konadu, E-mail: kakadee@gmail.com; Chua, Soo Jin [Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis # 08-03, Singapore 138634 (Singapore); Department of Electrical and Computer Engineering, National University of Singapore, E4-5-45, 4 Engineering Drive 3, Singapore 117576 (Singapore); Soh, Chew Beng [Singapore Institute of Technology, 10 Dover Drive, Singapore 138683 (Singapore); Liu, Hongfei [Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis # 08-03, Singapore 138634 (Singapore)

    2015-11-15

    The four nearest Si(111) multifaceted sidewalls were exposed inside an array of 3 μm-wide square holes patterned on an Si(100) substrate, and this patterned Si(100) substrate was used as a substrate for the deposition of a gallium nitride (GaN) epilayer. Subsequently the effect that the growth pressure, the etched-hole profiles, and the etched-hole arrangement had upon the quality of the as-grown GaN was investigated. The coalescence of the as-grown GaN epilayer on the exposed Si(111) facets was observed to be enhanced with reduced growth pressure from 120 to 90 Torr. A larger Si(001) plane area at the bottom of the etched holes resulted in bidirectional GaN domains, which resulted in poor material quality. The bidirectional GaN domains were observed as two sets of six peaks via a high-resolution x-ray diffraction phi scan of the GaN(10-11) reflection. It was also shown that a triangular array of etched holes was more desirable than square arrays of etched holes for the growth high-quality and continuous GaN films.

  12. Phylogenetic relationships of the ciliate class Heterotrichea (Protista, Ciliophora, Postciliodesmatophora) inferred from multiple molecular markers and multifaceted analysis strategy.

    Science.gov (United States)

    Shazib, Shahed Uddin Ahmed; Vd'ačný, Peter; Kim, Ji Hye; Jang, Seok Won; Shin, Mann Kyoon

    2014-09-01

    The ciliate class Heterotrichea is defined by somatic dikinetids bearing postciliodesmata, by an oral apparatus consisting of a paroral membrane and an adoral zone of membranelles, as well as by features of nuclear division involving extramacronuclear microtubules. Although phylogenetic interrelationships among heterotrichs have been analyzed several times, deeper nodes of the heterotrichean tree of life remain poorly resolved. To cast more light on the evolutionary history of heterotricheans, we performed phylogenetic analyses of multiple loci (18S rRNA gene, ITS1-5.8S rRNA-ITS2 region, and 28S rRNA gene) using traditional tree-building phylogenetic methods and statistical tree topology tests as well as phylogenetic networks, split spectrum analysis and quartet likelihood mapping. This multifaceted approach has shown that (1) Peritromus is very likely an adelphotaxon of all other heterotrichs; (2) Spirostomum and Anigsteinia are sister taxa and their common monophyletic origin is strongly supported by a uniquely posteriorly-thickened paroral membrane; (3) the monotypic family Chattonidiidae should be suppressed because its type genus clusters within the family Condylostomatidae; and (4) new families are needed for Gruberia and Fabrea because their affiliation with Spirostomidae and Climacostomidae, respectively, is not supported by molecular phylogenies nor the fine structure of the paroral membrane. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Multifaceted Investigation of Metabolites During Nitrogen Fixation in Medicago via High Resolution MALDI-MS Imaging and ESI-MS

    Science.gov (United States)

    Gemperline, Erin; Jayaraman, Dhileepkumar; Maeda, Junko; Ané, Jean-Michel; Li, Lingjun

    2015-01-01

    Legumes have developed the unique ability to establish a symbiotic relationship with soil bacteria known as rhizobia. This interaction results in the formation of root nodules in which rhizobia thrive and reduce atmospheric dinitrogen into plant-usable ammonium through biological nitrogen fixation (BNF). Owing to the availability of genetic information for both of the symbiotic partners, the Medicago truncatula- Sinorhizobium meliloti association is an excellent model for examining the BNF process. Although metabolites are important in this symbiotic association, few studies have investigated the array of metabolites that influence this process. Of these studies, most target only a few specific metabolites, the roles of which are either well known or are part of a well-characterized metabolic pathway. Here, we used a multifaceted mass spectrometric (MS) approach to detect and identify the key metabolites that are present during BNF using the Medicago truncatula- Sinorhizobium meliloti association as the model system. High mass accuracy and high resolution matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) Orbitrap instruments were used in this study and provide complementary results for more in-depth characterization of the nitrogen-fixation process. We used well-characterized plant and bacterial mutants to highlight differences between the metabolites that are present in functional versus nonfunctional nodules. Our study highlights the benefits of using a combination of mass spectrometric techniques to detect differences in metabolite composition and the distributions of these metabolites in plant biology.

  14. Fructose and NAFLD: The Multifaceted Aspects of  Fructose Metabolism.

    Science.gov (United States)

    Jegatheesan, Prasanthi; De Bandt, Jean-Pascal

    2017-03-03

    Among various factors, such as an unhealthy diet or a sedentarity lifestyle, excessive fructose consumption is known to favor nonalcoholic fatty liver disease (NAFLD), as fructose is both a substrate and an inducer of hepatic de novo lipogenesis. The present review presents some well-established mechanisms and new clues to better understand the pathophysiology of fructose-induced NAFLD. Beyond its lipogenic effect, fructose intake is also at the onset of hepatic inflammation and cellular stress, such as oxidative and endoplasmic stress, that are key factors contributing to the progression of simple steatosis to nonalcoholic steatohepatitis (NASH). Beyond its hepatic effects, this carbohydrate may exert direct and indirect effects at the peripheral level. Excessive fructose consumption is associated, for example, with the release by the liver of several key mediators leading to alterations in the communication between the liver and the gut, muscles, and adipose tissue and to disease aggravation. These multifaceted aspects of fructose properties are in part specific to fructose, but are also shared in part with sucrose and glucose present in energy- dense beverages and foods. All these aspects must be taken into account in the development of new therapeutic strategies and thereby to better prevent NAFLD.

  15. THE SECURITY OF CRITICAL ENERGY INFRASTRUCTURE IN THE AGE OF MULTIPLE ATTACK VECTORS: NATO’S MULTI-FACETED APPROACH

    Directory of Open Access Journals (Sweden)

    Sorin Dumitru Ducaru

    2017-06-01

    Full Text Available The current NATO threat landscape is characterized by a combination or “hybrid blend” of unconventional emerging challenges (like cyber and terrorist attacks and re-emerging conventional ones (like Russia’s recent military resurgence and assertiveness, that led to the illegal annexation of Crimea and destabilization in Eastern Ukraine. While the resurgence of the Russian military activity pushed the Alliance in the direction of re-discovering its deterrence and collective defence role, the new, not-traditional, trans-national and essentially non-military treats that generate effects below the threshold of an armed attack require a new paradigm shift with a focus on resilience although the protection of critical energy infrastructure is first and foremost a national responsibility, NATO can contribute to meeting the infrastructure protection challenge on many levels. Given the fact that its core deterrence and defence mandate relies in a great measure on the security of Allies’ energy infrastructure NATO’s role and actions in reducing the vulnerabilities and strengthening the resilience of such infrastructure can only increase. A multi-faceted, multi-stakeholder and networked approach is needed to be able to strengthen defences and resilience of critical infrastructure such as energy. Understanding and defending against cyber or terrorist threat vectors, increased situational awareness, education, training, exercises, trusted partnerships as well as increasing strategic security dialogue and cooperation are key for such a comprehensive/network approach to the challenge.

  16. Changes in students’ problem-solving strategies in a course that includes context-rich, multifaceted problems

    Directory of Open Access Journals (Sweden)

    C. A. Ogilvie

    2009-08-01

    Full Text Available Most students struggle when faced with complex and open-ended tasks because the strategies taught in schools and universities simply require finding and applying the correct formulae or strategy to answer well-structured, algorithmic problems. For students to develop their ability to solve ill-structured problems, they must first believe that standardized procedural approaches will not always be sufficient for solving engineering and scientific challenges. In this paper we document the range of beliefs university students have about problem solving. Students enrolled in a physics course submitted a written reflection both at the start and the end of the course on how they solve problems. We coded approximately 500 of these reflections for the presence of different problem-solving approaches. At the start of the semester over 50% of the students mention in written reflections that they use Rolodex equation matching, i.e., they solve problems by searching for equations that have the same variables as the knowns and unknowns. We then describe the extent to which students’ beliefs about physics problem solving change by the end of a semester-long course that emphasized problem solving via context-rich, multifaceted problems. The frequency of strategies such as the Rolodex method reduces only slightly by the end of the semester. However, there is an increase in students describing more expansive strategies within their reflections. In particular there is a large increase in describing the use of diagrams, and thinking about concepts first.

  17. [Study of defense styles, defenses and coping strategies in alcohol-dependent population].

    Science.gov (United States)

    Ribadier, A; Varescon, I

    2017-05-01

    Defense mechanisms have been seen to greatly change over time and across different definitions made by different theoretical currents. Recently with the definition provided by the DSM IV, defense mechanisms have integrated the concept of coping as a defensive factor. These mechanisms are no longer considered just through a psychodynamic approach but also through a cognitive and behavioral one. In recent years, new theories have therefore integrated these two components of the defensive operation. According to Chabrol and Callahan (2013), defense mechanisms precede coping strategies. In individuals with psychopathological disorders, these authors indicate a relative stability of these mechanisms. Also, we asked about the presence of unique characteristics among people with alcohol dependence. Indeed, studies conducted with people with alcohol dependence highlight the presence of a neurotic defense style and some highly immature defenses (projection, acting out, splitting and somatization). In terms of coping strategies, persons with alcohol dependence preferentially use avoidant strategies and strategies focused on emotion. However, although several studies have been conducted to assess coping strategies and defense styles within a population of individuals with an alcohol problem, at the present time none of them has taken into account all these aspects of defense mechanisms. The aim of this study is therefore to study the defenses and defense styles and coping strategies in an alcohol-dependent population. This multicenter study (3 CHU, 1 center of supportive care and prevention in addiction and 1 clinic) received a favorable opinion of an Institutional Review Board (IRB Registration #: 00001072). Eighty alcohol-dependent individuals responded to a questionnaire assessing sociodemographic characteristics and elements related to the course of consumption. Coping strategies were assessed by means of a questionnaire validated in French: the Brief Cope. The Defense

  18. Defense Meteorological Satellite Program (DMSP) Film

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The United States Air Force Defense Meteorological Satellite Program (DMSP) Operational Linescan System (OLS) is a polar orbiting meteorological sensor with two...

  19. Happiness and Defense Styles in Psychiatrists.

    Science.gov (United States)

    Machado, Leonardo; Tavares, Hermano; Petribú, Kátia; Pinto, Tiago; Cantilino, Amaury

    2016-03-01

    The aim of this study was to measure happiness in a sample of Brazilian psychiatrists and correlate it with the defense styles used by them and sociodemographic data. This study was observational, cross-sectional, and analytical. Data were collected through self-administered questionnaires by Brazilian psychiatrists who participated in the XXXII Brazilian Congress of Psychiatry, 2014. In this sample of psychiatrists, happiness levels were high (scoring 5.69 of a total of 7), and mature defense styles prevailed, especially humor and anticipation. In a multivariate analysis, having children, good sleep quality, increased sexual interest, and use of defense styles such as humor, anticipation, and idealization all showed a positive relationship with happiness; on the other hand, using defense style such as acting out or annulment demonstrated a negative relationship with happiness. Despite the well-known professional burden that they bear, Brazilian psychiatrists surveyed presented, in general, high levels of subjective well-being and happiness.

  20. Active Cyber Defense Dynamics Exhibiting Rich Phenomena

    CERN Document Server

    Zheng, Ren; Xu, Shouhuai

    2016-01-01

    The Internet is a man-made complex system under constant attacks (e.g., Advanced Persistent Threats and malwares). It is therefore important to understand the phenomena that can be induced by the interaction between cyber attacks and cyber defenses. In this paper, we explore the rich phenomena that can be exhibited when the defender employs active defense to combat cyber attacks. To the best of our knowledge, this is the first study that shows that {\\em active cyber defense dynamics} (or more generally, {\\em cybersecurity dynamics}) can exhibit the bifurcation and chaos phenomena. This has profound implications for cyber security measurement and prediction: (i) it is infeasible (or even impossible) to accurately measure and predict cyber security under certain circumstances; (ii) the defender must manipulate the dynamics to avoid such {\\em unmanageable situations} in real-life defense operations.

  1. Formerly Used Defense Sites (FUDS) Public Properties

    Data.gov (United States)

    Department of Homeland Security — The FUDS Public GIS dataset contains point location information for the 2,709 Formerly Used Defense Sites (FUDS) properties where the U.S. Army Corps of Engineers is...

  2. The Impact of Declining Defense Budgets on Japan Maritime Self Defense Force

    Science.gov (United States)

    2007-06-01

    structural reform, the GOJ is trying to reduce all expenditures , including defense expenditures . Conversely, Japan and countries in its vicinity face the...reform, the GOJ is trying to reduce all expenditures , including defense expenditures . Conversely, Japan and countries in its vicinity face the threat...reduce expenditures . The alternative was serious financial trouble for Japan in the near future. The impact of these reforms is that defense is no

  3. Defense Downsizing and Blacks in the Military

    Science.gov (United States)

    1993-06-01

    8217IIa NAVAL POSTGRADUATE SCHOOL Monterey, California AD-A272 415 THESIS DEFENSE DOWNSIZING AND BLACKS IN THE MILITARY by Roy L. Nixon June 1993 Thesis...include security classification) DEFENSE DOWNSIZING AND BLACKS IN TIE MILITARY 12 Plersonal Author(s) Roy L. Nixon 1 3a Type of Report I13b Time Covered...end of the draft. However. the armed forces are now engaged in the process of downsizing , and there is some speculation that blacks may be

  4. Guam: U.S. Defense Deployments

    Science.gov (United States)

    2013-11-15

    Gates Views Growth Under Way in Guam,” American Forces Press Service, May 30, 2008. 2 Secretary of Defense Robert Gates, speech at Shangri-La Hotel ...crises; and sea lines of communication (SLOCs), particularly through the Straits of Malacca . Combat aircraft on Guam can reach Taiwan, Japan, Philippines...Remarks by retired Lieutenant General, USMC, George Trautman III, at Heritage Foundation, May 3, 2012. Guam: U.S. Defense Deployments Congressional

  5. [Medical Service of the Estonian Defense Forces].

    Science.gov (United States)

    Anisimov, A S; Golota, A S; Krassii, A B; Soldatov, E A; Shalakin, R A

    2015-06-01

    The article is a brief description of the current state of the Estonian Defense Forces medical service and is based on the study of the open access foreign sources. At the beginning, the general information about Estonia, its Defense Forces, and their medical service is presented. Then the medical service particular features are described with more detail, namely, the organization of the inpatient and outpatient treatment, medical supply, scientific research, combat medicine, medical staff education and training, medical service personnel income.

  6. Surfing China’s National Defense

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Following the start of its first test run on August 20, 2009, the website www.mod.gov.cn of the Ministry of National Defense (MOD) of the People’s Republic of China has logged more than 2 billion hits, from many countries and regions including China, the United States, the United Kingdom, Japan, Australia and Singapore. China National Defense News reporters recently interviewed Ji Guilin, the website’s Editor in Chief, on its performance and the feedback of netizens.

  7. Carp erythrodermatitis: host defense-pathogen interaction.

    OpenAIRE

    Pourreau, C.N.

    1990-01-01

    The outcome of a bacterial infection depends on the interaction between pathogen and host. The ability of the microbe to survive in the host depends on its invasive potential (i.e. spreading and multiplication), and its ability to obtain essential nutrients and to resist the host's defense system. On the other hand, the host's resistance to a bacterial attack depends on its physiological state, the intensity of the bacterial attack and the efficacy of the defense system to neutralize toxins a...

  8. The Future of Theater Missile Defense

    Science.gov (United States)

    1994-06-01

    withERINT) 1,500 IVf 74C 1998 3.0 Navy Lower-Tier Defense 1,820 SO4 50* 1999° 3* THAAD(withTMD-GBR) 1,313 80 14 2001e 9.1 AdvaaoedCapabflitylMD Systems...Administration cannot, by itself, provide a sufficient buffer between theater and strategic missile defenses. Other limits must be included. Finally, the

  9. Department of Defense Recovering Warrior Task Force

    Science.gov (United States)

    2014-09-02

    233 Baldor , L.C. (April 26, 2010). Top Wounded Warrior official: I was forced out. Retrieved May 26, 2014, from http://www.armytimes.com/article...Coordination briefing to the Defense Advisory Committee on Women in the Services. 244 Baldor , L.C. (April 26, 2010). Top Wounded Warrior official: I was...2014, from http://www.defense.gov/news/newsarticle.aspx?id=121796.  Baldor , L.C. (April 26, 2010). Top Wounded Warrior official: I was forced out

  10. Plant defense using toxic inorganic ions: conceptual models of the defensive enhancement and joint effects hypotheses.

    Science.gov (United States)

    Boyd, Robert S

    2012-10-01

    The concept of plant defense using toxic mineral elements originated as an explanation for extremely elevated concentrations of some elements (termed hyperaccumulation) in some plant tissues. The Defensive Enhancement Hypothesis suggests that hyperaccumulation evolved because, after an initial defensive benefit accrued from a relatively low initial concentration, increased concentration of an element provided increased plant fitness and drove evolution of higher element concentrations until hyperaccumulation was achieved. The Joint Effects Hypothesis postulates that additive or synergistic effects between element-based defenses, or between toxic element and organic chemical defenses, may have contributed to the evolution of hyperaccumulation. By lessening the concentration of an element necessary to provide an initial defensive benefit to a plant, joint effects could decrease the level of an element that provides an initial defensive benefit, allowing additive or synergistic defensive enhancement to take effect. Recent experimental tests have demonstrated defense at relatively low element concentrations, and tests of metal/metal and metal/organic compound combinations have shown joint effects. These hypotheses suggest how hyperaccumulator plants may have evolved in response to plant-herbivore interactions, and suggest that toxic element levels below those used to define hyperaccumulation may be ecologically effective. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  11. Quadrennial Defense Review 2014: trends in US defense policy and consequences for NATO

    OpenAIRE

    Overhaus, Marco

    2014-01-01

    Every four years the Pentagon publishes a report on the central developments and trends in US defense policy. The Quadrennial Defense Review (QDR) released in early March 2014 is the first to include in more detail the consequences of the defense budget cuts passed since 2011. Otherwise, the so-called US rebalance to the Asia-Pacific region and the war-weariness of the American people are the principal factors shaping US defense policy. While not representing a watershed for transatlantic def...

  12. Self-Defense in Karabakh Conflict?

    Directory of Open Access Journals (Sweden)

    Saeed Bagheri

    2015-01-01

    Full Text Available Use of force is one of the principles of international law that has been banned by the UN Charter and modern constitutions. However, since the enforcement of the UN Charter, self-defense has become the preferred excuse for states to justify their use of force. Applying self-defense, however, requires some conditions. Immediacy is one of the important conditions of self-defense. This is defined as the timeframe between armed attacks and reaction to it. This situation requires self-defense immediately after the armed conflict or during a reasonable timeframe since its occurance.In this respect, emerging Karabakh Conflict between Armenia and Azerbaijan in the 1990s is important. In this article, by comparing two different approaches (strict and board interpretation of the temporal link between the measures of self-defense and the armed attacks (immediacy, the temporal link between the self-defense countermeasures of Azerbaijan and attacks by Armenia in Karabakh Conflict will be examined.

  13. Department of Defense Healthcare Management System Modernization (DHMSM)

    Science.gov (United States)

    2016-03-01

    2016 Major Automated Information System Annual Report Department of Defense Healthcare Management System Modernization (DHMSM) Defense...Secretary of Defense PB - President’s Budget RDT&E - Research, Development, Test, and Evaluation SAE - Service Acquisition Executive TBD - To Be...DSN Fax: Date Assigned: November 16, 2015 Program Information Program Name Department of Defense Healthcare Management System Modernization

  14. 76 FR 22681 - Defense Logistics Agency (DLA) Address Directory

    Science.gov (United States)

    2011-04-22

    ... of the Secretary Defense Logistics Agency (DLA) Address Directory AGENCY: Department of Defense. ACTION: Notice. SUMMARY: The Defense Logistics Agency (DLA) is updating its Address Directory which is.... Jody Sinkler, 703-767-5045. SUPPLEMENTARY INFORMATION: DLA Address Directory: Defense Logistics...

  15. 78 FR 25853 - Defense Logistics Agency Privacy Program

    Science.gov (United States)

    2013-05-03

    ... of the Secretary 32 CFR Part 323 RIN 0790-AI86 Defense Logistics Agency Privacy Program AGENCY: Defense Logistics Agency, DoD. ACTION: Final rule. SUMMARY: The Defense Logistics Agency (DLA) is revising... Defense Logistics Agency's implementation of the Privacy Act of 1974, as amended. In addition, DLA...

  16. 78 FR 17176 - Federal Acquisition Regulation; Defense Base Act

    Science.gov (United States)

    2013-03-20

    ... Act as extended by the Defense Base Act. II. Discussion and Analysis The Defense Base Act of 1941...-insurer; to submit a timely, written report to the Department of Labor (DOL) in the event of an employee's... (Defense Base Act), merely clarify the existing requirements set forth in the Defense Base Act of 1941...

  17. Health Alliance for prudent antibiotic prescribing in patients with respiratory tract infections (HAPPY AUDIT) -impact of a non-randomised multifaceted intervention programme

    DEFF Research Database (Denmark)

    Bjerrum, Lars; Munck, Anders; Gahrn-Hansen, Bente

    2011-01-01

    Excessive use of antibiotics is worldwide the most important reason for development of antimicrobial resistance. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial re...... practice setting. The aim of this study was to evaluate the impact of a multifaceted intervention targeting general practitioners (GPs) and patients in six countries with different health organization and different prevalence of antibiotic resistance....

  18. The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock.

    Science.gov (United States)

    Arabi, Yaseen M; Al-Dorzi, Hasan M; Alamry, Ahmed; Hijazi, Ra'ed; Alsolamy, Sami; Al Salamah, Majid; Tamim, Hani M; Al-Qahtani, Saad; Al-Dawood, Abdulaziz; Marini, Abdellatif M; Al Ehnidi, Fatimah H; Mundekkadan, Shihab; Matroud, Amal; Mohamed, Mohamed S; Taher, Saadi

    2017-12-01

    Compliance with the clinical practice guidelines of sepsis management has been low. The objective of our study was to describe the results of implementing a multifaceted intervention including an electronic alert (e-alert) with a sepsis response team (SRT) on the outcome of patients with sepsis and septic shock presenting to the emergency department. This was a pre-post two-phased implementation study that consisted of a pre-intervention phase (January 01, 2011-September 24, 2012), intervention phase I (multifaceted intervention including e-alert, from September 25, 2012-March 03, 2013) and intervention phase II when SRT was added (March 04, 2013-October 30, 2013) in a 900-bed tertiary-care academic hospital. We recorded baseline characteristics and processes of care in adult patients presenting with sepsis or septic shock. The primary outcome measures were hospital mortality. Secondary outcomes were the need for mechanical ventilation and length of stay in the intensive unit and in the hospital. After implementing the multifaceted intervention including e-alert and SRT, cases were identified with less severe clinical and laboratory abnormalities and the processes of care improved. When adjusted to propensity score, the interventions were associated with reduction in hospital mortality [for intervention phase II compared to pre-intervention: adjusted odds ratio (aOR) 0.71, 95% CI 0.58-0.85, p = 0.003], reduction in the need for mechanical ventilation (aOR 0.45, 95% CI 0.37-0.55, p < 0.0001) and reduction in ICU LOS and hospital LOS for all patients as well as ICU LOS for survivors. Implementing a multifaceted intervention including sepsis e-alert with SRT was associated with earlier identification of sepsis, increase in compliance with sepsis resuscitation bundle and reduction in the need for mechanical ventilation and reduction in hospital mortality and LOS.

  19. Efficacy of a multifaceted podiatry intervention to improve balance and prevent falls in older people: study protocol for a randomised trial

    OpenAIRE

    Menz Hylton B; Spink Martin J; Lord Stephen R

    2008-01-01

    Abstract Background Falls in older people are a major public health problem, with at least one in three people aged over 65 years falling each year. There is increasing evidence that foot problems and inappropriate footwear increase the risk of falls, however no studies have been undertaken to determine whether modifying these risk factors decreases the risk of falling. This article describes the design of a randomised trial to evaluate the efficacy of a multifaceted podiatry intervention to ...

  20. Machinability of drilling T700/LT-03A carbon fiber reinforced plastic (CFRP) composite laminates using candle stick drill and multi-facet drill

    Science.gov (United States)

    Wang, Cheng-Dong; Qiu, Kun-Xian; Chen, Ming; Cai, Xiao-Jiang

    2015-03-01

    Carbon Fiber Reinforced Plastic (CFRP) composite laminates are widely used in aerospace and aircraft structural components due to their superior properties. However, they are regarded as difficult-to-cut materials because of bad surface quality and low productivity. Drilling is the most common hole making process for CFRP composite laminates and drilling induced delamination damage usually occurs severely at the exit side of drilling holes, which strongly deteriorate holes quality. In this work, the candle stick drill and multi-facet drill are employed to evaluate the machinability of drilling T700/LT-03A CFRP composite laminates in terms of thrust force, delamination, holes diameter and holes surface roughness. S/N ratio is used to characterize the thrust force while an ellipse-shaped delamination model is established to quantitatively analyze the delamination. The best combination of drilling parameters are determined by full consideration of S/N ratios of thrust force and the delamination. The results indicate that candle stick drill will induce the unexpected ellipse-shaped delamination even at its best drilling parameters of spindle speed of 10,000 rpm and feed rate of 0.004 mm/tooth. However, the multi-facet drill cutting at the relative lower feed rate of 0.004 mm/tooth and lower spindle speed of 6000 rpm can effectively prevent the delamination. Comprehensively, holes quality obtained by multi-facet drill is much more superior to those obtained by candle stick drill.

  1. 22 CFR 124.15 - Special Export Controls for Defense Articles and Defense Services Controlled under Category XV...

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Special Export Controls for Defense Articles...-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.15 Special Export Controls for Defense Articles and Defense Services Controlled under Category XV: Space Systems and Space Launches. (a) The export of...

  2. A Laboratory for Characterizing the Efficacy of Moving Target Defense

    Science.gov (United States)

    2016-10-25

    SECURITY CLASSIFICATION OF: Under ARO funded BAA project entitled “Modeling and Analysis of Moving Target Defense Mechanisms in MANET ”, we at College...Efficacy of Moving Target Defense Report Title Under ARO funded BAA project entitled “Modeling and Analysis of Moving Target Defense Mechanisms in MANET ...Defense 1 Statement of the Problem Under ARO funded BAA project entitled “Modeling and Analysis of Moving Target Defense Mechanisms in MANET ”, we

  3. The future of planetary defense

    Science.gov (United States)

    Mainzer, A.

    2017-04-01

    Asteroids and comets have impacted Earth in the past and will do so in the future. While the frequency of impacts is reasonably well understood on geologic timescales, it is difficult to predict the next sizeable impact on human timescales by extrapolation from population statistics alone. Fortunately, by identifying and tracking individual objects, we can make precise predictions of any potential close encounters with Earth. As more advance notice is provided, the range of possible mitigation options expands. While the chance of an impact is very small, the potential consequences can be severe, meaning that sensible risk reduction measures should be undertaken. By implementing surveys, the risk of an unforeseen impact can be greatly reduced: the first step is finding the objects. Fortunately, the worldwide community of professional and amateur astronomers has made significant progress in discovering large near-Earth objects (NEOs). More than 95% of NEOs capable of causing global devastation (objects larger than 1 km in diameter) have been discovered, and none of these pose an impact hazard in the near future. Infrastructure is in place to link observations and compute close approaches in real time. Interagency and international collaborations have been undertaken to strengthen cooperative efforts to plan potential mitigation and civil defense campaigns. Yet much remains to be done. Approximately 70% of NEOs larger than 140 m (large enough to cause severe regional damage) remain undiscovered. With the existing surveys, it will take decades to identify the rest. Progress can be accelerated by undertaking new surveys with improved sensitivity.Plain Language SummaryAsteroids and comets have impacted Earth in the past and will do so in the future. Fortunately, by identifying and tracking them, we have the ability to predict any potential close encounters with Earth. By observing the sky repeatedly to search for near-Earth objects, the risk of an unforeseen impact can

  4. Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control.

    Science.gov (United States)

    Modig, Fredrik; Fransson, Per-Anders; Magnusson, Måns; Patel, Mitesh

    2012-02-01

    Alcohol-related falls are recognized as a major contributor to the occurrence of traumatic brain injury. The control of upright standing balance is complex and composes of contributions from several partly independent mechanisms such as appropriate information from multiple sensory systems and correct feedback and feed forward movement control. Analysis of multisegmented body movement offers a rarely used option for detecting the fine motor problems associated with alcohol intoxication. The study aims were to investigate whether (1) alcohol intoxication at 0.06 and 0.10% blood alcohol concentration (BAC) affected the body movements under unperturbed and perturbed standing; and (2) alcohol affected the ability for sensorimotor adaptation. Body movements were recorded in 25 participants (13 women and 12 men, mean age 25.1 years) at five locations (ankle, knee, hip, shoulder, and head) during quiet standing and during balance perturbations from pseudorandom pulses of calf muscle vibration over 200s with eyes closed or open. Tests were performed at 0.00, 0.06, and 0.10% BAC. The study revealed several significant findings: (1) an alcohol dose-specific effect; (2) a direction-specific stability decrease from alcohol intoxication; (3) a movement pattern change related to the level of alcohol intoxication during unperturbed standing and perturbed standing; (4) a sensorimotor adaptation deterioration with increased alcohol intoxication; and (5) that vision provided a weaker contribution to postural control during alcohol intoxication. Hence, alcohol intoxication at 0.06 and 0.10% BAC causes a complex multifaceted deterioration of human postural control.

  5. The Multifaceted Roles of Adipose Tissue-Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture.

    Science.gov (United States)

    Scherer, Philipp E

    2016-06-01

    The Banting Medal for Scientific Achievement is the highest scientific award of the American Diabetes Association (ADA). Given in memory of Sir Frederick Banting, one of the key investigators in the discovery of insulin, the Banting Medal is awarded annually for scientific excellence, recognizing significant long-term contributions to the understanding, treatment, or prevention of diabetes. Philipp E. Scherer, PhD, of the Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, received the prestigious award at the ADA's 75th Scientific Sessions, 5-9 June 2015, in Boston, MA. He presented the Banting Lecture, "The Multifaceted Roles of Adipose Tissue-Therapeutic Targets for Diabetes and Beyond," on Sunday, 7 June 2015.A number of different cell types contribute to the cellular architecture of adipose tissue. Although the adipocyte is functionally making important contributions to systemic metabolic homeostatis, several additional cell types contribute a supportive role to bestow maximal flexibility on the tissue with respect to many biosynthetic and catabolic processes, depending on the metabolic state. These cells include vascular endothelial cells, a host of immune cells, and adipocyte precursor cells and fibroblasts. Combined, these cell types give rise to a tissue with remarkable flexibility with respect to expansion and contraction, while optimizing the ability of the tissue to act as an endocrine organ through the release of many protein factors, critically influencing systemic lipid homeostasis and biochemically contributing many metabolites. Using an example from each of these categories-adiponectin as a key adipokine, sphingolipids as critical mediators of insulin sensitivity, and uridine as an important metabolite contributed by the adipocyte to the systemic pool-I will discuss the emerging genesis of the adipocyte over the past 20 years from metabolic bystander to key driver of metabolic flexibility.

  6. Exploring a Multifaceted Syllabus Design for Teaching Short Surahs of Qur’an to Novice-Non-Arabic-Speaking Muslims

    Directory of Open Access Journals (Sweden)

    Amira A. Saleh

    2015-04-01

    Full Text Available The paper’s aim is to propose a design a syllabus for the new Muslims who have recently  converted to Islam. The syllabus is multifaceted, addressing the basic linguistic, stylistic, and lexical features of 3 surahs (chapters in the holy book in addition to highlighting the most basic information a new Muslim has to know about the sacred book. These features have been presented and graded according to the needs of the students (new Muslims. Three Surahs[1] (Al Fatihah, (Al Ikhlas, and (Al Nasr will be presented in their translated and transliterated forms in relation to their original Arabic texts, so as to understand these Arabic words when students listen or try to practice them in their daily five prayers. In addition, a practicum session will be given to students in which they apply what they have learned through the first Surah (Al Fatihah.  The practicum session includes the analysis of this Surah using the main seven features presented in the theoretical section. Versions of pre and post questionnaires will be administered with the syllabus to the students to test how far they have benefited from this course.Keywords: ESP for Teaching Qur’an- Linguistic Analysis of Surahs- Stylistic Analysis of Surahs-Lexical Analysis of Surahs- Syllabus Format- Analysis of Surah (Al Fatihah,  Non-NativeArabic-Speaking-Muslims-NNASM[1]A Surah (also spelled Sura in Arabic is a “chapter of the Qur'an, traditionally arranged roughly in order of decreasing length. Each Surah is named for a word or name mentioned in one of its ayat (sections.” (Urban Dictionary, n.d. para. 1

  7. Effectiveness of pharmacovigilance: multifaceted educational intervention related to the knowledge, skills and attitudes of multidisciplinary hospital staff

    Directory of Open Access Journals (Sweden)

    Fabiana Rossi Varallo

    Full Text Available OBJECTIVES: Most educational interventions in pharmacovigilance are designed to encourage physicians to report adverse drug reactions. However, multidisciplinary teams may play an important role in reporting drug-related problems. This study assessed the impact of a multifaceted educational intervention in pharmacovigilance on the knowledge, skills and attitudes of hospital professionals. METHOD: This prospective, open-label, non-randomized study was performed in a medium-complexity hospital in São Paulo, Brazil. The intervention involved four activities: 1 an interactive lecture, 2 a practical class, 3 a pre-post questionnaire administered to professionals on a multidisciplinary team, and 4 educational material. The intervention’s impact on the professionals’ knowledge and skills was assessed using the World Health Organization’s definitions. The intervention’s effect on the professionals’ attitudes was analysed by the prevalence of adverse drug event reports (adverse drug reactions, medication errors, therapeutic failure and drug quality deviations and the relevance (seriousness and expectancy of the events. RESULTS: One hundred seventy-three professionals were enrolled. A 70-fold increase in the number of adverse drug event reports was observed during the 12 months post-intervention. The intervention improved the professionals’ form-completion skills (p<0.0001 and their knowledge of pharmacovigilance (p<0.0001. The intervention also contributed to detecting serious drug-induced events. The nursing staff reported medication errors, and pharmacists and physiotherapists recognized serious adverse drug reactions. Physicians communicated suspicions of therapeutic failure. CONCLUSIONS: A multidisciplinary approach to drug-safety assessments contributes to identifying new, relevant drug-related problems and improving the rate of adverse drug event reporting. This strategy may therefore be applied to improve risk communication in

  8. Multifaceted Intervention to Prevent Venous Thromboembolism in Patients Hospitalized for Acute Medical Illness: A Multicenter Cluster-Randomized Trial.

    Directory of Open Access Journals (Sweden)

    Pierre-Marie Roy

    Full Text Available Misuse of thromboprophylaxis may increase preventable complications for hospitalized medical patients.To assess the net clinical benefit of a multifaceted intervention in emergency wards (educational lectures, posters, pocket cards, computerized clinical decision support systems and, where feasible, electronic reminders for the prevention of venous thromboembolism.Prospective cluster-randomized trial in 27 hospitals. After a pre-intervention period, centers were randomized as either intervention (n = 13 or control (n = 14. All patients over 40 years old, admitted to the emergency room, and hospitalized in a medical ward were included, totaling 1,402 (712 intervention and 690 control and 15,351 (8,359 intervention and 6,992 control in the pre-intervention and intervention periods, respectively.Symptomatic venous thromboembolism or major bleeding (primary outcome occurred at 3 months in 3.1% and 3.2% of patients in the intervention and control groups, respectively (adjusted odds ratio: 1.02 [95% confidence interval: 0.78-1.34]. The rates of thromboembolism (1.9% vs. 1.9%, major bleedings (1.2% vs. 1.3%, and mortality (11.3% vs. 11.1% did not differ between the groups. Between the pre-intervention and intervention periods, the proportion of patients who received prophylactic anticoagulant treatment more steeply increased in the intervention group (from 35.0% to 48.2%: +13.2% than the control (40.7% to 44.1%: +3.4%, while the rate of adequate thromboprophylaxis remained stable in both groups (52.4% to 50.9%: -1.5%; 49.1% to 48.8%: -0.3%.Our intervention neither improved adequate prophylaxis nor reduced the rates of clinical events. New strategies are required to improve thromboembolism prevention for hospitalized medical patients.ClinicalTrials.gov NCT01212393.

  9. In Defense of the Defense: The Continuing Political Value of Denial of Enemy Aims

    Science.gov (United States)

    2013-01-01

    Space Power Journal | 84 Kraig In Defense of the Defense Feature leaving all of their logistics, population, industrial, energy, food , com- munications...expenditure of effort consists in the wastage of his forces—our destruction of them” (emphases in original).61 He then refers to this de- fensive form of

  10. 75 FR 65437 - Defense Federal Acquisition Regulation Supplement; Defense Cargo Riding Gang Members (DFARS Case...

    Science.gov (United States)

    2010-10-25

    ... Acquisition Regulation Supplement; Defense Cargo Riding Gang Members (DFARS Case 2007-D002) AGENCY: Defense... 3504 addresses requirements that apply to riding gang members and DoD- exempted individuals who perform.... 109-364). Section 3504 addresses requirements that apply to riding gang members and...

  11. Is flood defense changing in nature? Shifts in the flood defense strategy in six European countries

    Directory of Open Access Journals (Sweden)

    Mathilde Gralepois

    2016-12-01

    Full Text Available In many countries, flood defense has historically formed the core of flood risk management but this strategy is now evolving with the changing approach to risk management. This paper focuses on the neglected analysis of institutional changes within the flood defense strategies formulated and implemented in six European countries (Belgium, England, France, the Netherlands, Poland, and Sweden. The evolutions within the defense strategy over the last 30 years have been analyzed with the help of three mainstream institutional theories: a policy dynamics-oriented framework, a structure-oriented institutional theory on path dependency, and a policy actors-oriented analysis called the advocacy coalitions framework. We characterize the stability and evolution of the trends that affect the defense strategy in the six countries through four dimensions of a policy arrangement approach: actors, rules, resources, and discourses. We ask whether the strategy itself is changing radically, i.e., toward a discontinuous situation, and whether the processes of change are more incremental or radical. Our findings indicate that in the European countries studied, the position of defense strategy is continuous, as the classical role of flood defense remains dominant. With changing approaches to risk, integrated risk management, climate change, urban growth, participation in governance, and socioeconomic challenges, the flood defense strategy is increasingly under pressure to change. However, these changes can be defined as part of an adaptation of the defense strategy rather than as a real change in the nature of flood risk management.

  12. Is flood defense changing in nature? Shifts in the flood defense strategy in six European countries

    NARCIS (Netherlands)

    Gralepois, M.; Larrue, C.; Wiering, M.A.; Crabbé, A.; Tapsell, S.; Mees, H.; Ek, K.; Szwed, M.

    2016-01-01

    ABSTRACT. In many countries, flood defense has historically formed the core of flood risk management but this strategy is now evolving with the changing approach to risk management. This paper focuses on the neglected analysis of institutional changes within the flood defense strategies formulated

  13. Is flood defense changing in nature? Shifts in the flood defense strategy in six European countries

    NARCIS (Netherlands)

    Gralepois, M.; Larrue, C.; Wiering, M.A.; Crabbé, A.; Tapsell, S.; Mees, H.; Ek, K.; Szwed, M.

    2016-01-01

    ABSTRACT. In many countries, flood defense has historically formed the core of flood risk management but this strategy is now evolving with the changing approach to risk management. This paper focuses on the neglected analysis of institutional changes within the flood defense strategies formulated a

  14. DCT-based cyber defense techniques

    Science.gov (United States)

    Amsalem, Yaron; Puzanov, Anton; Bedinerman, Anton; Kutcher, Maxim; Hadar, Ofer

    2015-09-01

    With the increasing popularity of video streaming services and multimedia sharing via social networks, there is a need to protect the multimedia from malicious use. An attacker may use steganography and watermarking techniques to embed malicious content, in order to attack the end user. Most of the attack algorithms are robust to basic image processing techniques such as filtering, compression, noise addition, etc. Hence, in this article two novel, real-time, defense techniques are proposed: Smart threshold and anomaly correction. Both techniques operate at the DCT domain, and are applicable for JPEG images and H.264 I-Frames. The defense performance was evaluated against a highly robust attack, and the perceptual quality degradation was measured by the well-known PSNR and SSIM quality assessment metrics. A set of defense techniques is suggested for improving the defense efficiency. For the most aggressive attack configuration, the combination of all the defense techniques results in 80% protection against cyber-attacks with PSNR of 25.74 db.

  15. Insanity Defense: Past, Present, and Future.

    Science.gov (United States)

    Math, Suresh Bada; Kumar, Channaveerachari Naveen; Moirangthem, Sydney

    2015-01-01

    Insanity defense is primarily used in criminal prosecutions. It is based on the assumption that at the time of the crime, the defendant was suffering from severe mental illness and therefore, was incapable of appreciating the nature of the crime and differentiating right from wrong behavior, hence making them not legally accountable for crime. Insanity defense is a legal concept, not a clinical one (medical one). This means that just suffering from a mental disorder is not sufficient to prove insanity. The defendant has the burden of proving the defense of insanity by a "preponderance of the evidence" which is similar to a civil case. It is hard to determine legal insanity, and even harder to successfully defend it in court. This article focuses on the recent Supreme Court decision on insanity defense and standards employed in Indian court. Researchers present a model for evaluating a defendant's mental status examination and briefly discuss the legal standards and procedures for the assessment of insanity defense evaluations. There is an urgent need to initiate formal graduation course, setup Forensic Psychiatric Training and Clinical Services Providing Centers across the country to increase the manpower resources and to provide fair and speedy trail.

  16. Spatial mosaic evolution of snail defensive traits

    Directory of Open Access Journals (Sweden)

    de León Francisco

    2007-03-01

    Full Text Available Abstract Background Recent models suggest that escalating reciprocal selection among antagonistically interacting species is predicted to occur in areas of higher resource productivity. In a putatively coevolved interaction between a freshwater snail (Mexipyrgus churinceanus and a molluscivorous cichlid (Herichthys minckleyi, we examined three components of this interaction: 1 spatial variation in two putative defensive traits, crushing resistance and shell pigmentation; 2 whether abiotic variables or frequency of molariform cichlids are associated with spatial patterns of crushing resistance and shell pigmentation and 3 whether variation in primary productivity accounted for small-scale variation in these defensive traits. Results Using spatial autocorrelation to account for genetic and geographic divergence among populations, we found no autocorrelation among populations at small geographic and genetic distances for the two defensive traits. There was also no correlation between abiotic variables (temperature and conductivity and snail defensive traits. However, crushing resistance and frequency of pigmented shells were negatively correlated with molariform frequency. Crushing resistance and levels of pigmentation were significantly higher in habitats dominated by aquatic macrophytes, and both traits are phenotypically correlated. Conclusion Crushing resistance and pigmentation of M. churinceanus exhibit striking variation at small spatial scales often associated with differences in primary productivity, substrate coloration and the frequency of molariform cichlids. These local geographic differences may result from among-habitat variation in how resource productivity interacts to promote escalation in prey defenses.

  17. Multi-faceted AGN

    Science.gov (United States)

    Farrar, Glennys R.; Chen, Yanping; Dai, Yuxiao; Zaw, Ingyin

    2016-08-01

    An interesting question is how frequently an object is an AGN by multiple different criteria — e.g., is simultaneously a narrow-line optical AGN and an X-ray or radio AGN, possibly as a function of luminosities in the various wavebands and perhaps host galaxy type. Answering such questions quantitatively has been difficult up to now because of the lack of a complete, uniformly selected optical AGN catalog. Here we report first results of such an analysis, using the new, all-sky catalog of uniformly selected optical AGNs from Zaw, Chen and Farrar (2016), the Swift-BAT 70-month catalog of X-ray AGN (Baumgartner et al., 2013), and the van Velzen et al. (2012) catalog of radio AGN.

  18. The multifaceted skyrmion

    CERN Document Server

    Rho, Mannque

    2010-01-01

    This is a sequel to the World Scientific volume edited by Gerald E Brown in 1994 entitled ""Selected Papers"", with Commentary, of 'Tony Hilton Royle Skyrme'. There has been a series of impressive developments in the application of the skyrmion structure to wide-ranging physical phenomena. The first volume was mainly focused on the rediscovery of the skyrmion in 1983 in the context of Quantum Chromodynamics (QCD) and on its striking role in nuclear physics. Since 1994, skyrmions have been found to play an even greater role not only in various aspects of particle physics and astrophysics but al

  19. Icosahedrons: A Multifaceted Project.

    Science.gov (United States)

    Strazdin, Ray

    2000-01-01

    Discusses a project focusing on icosahedrons that combines geometry, structure, graphic design, animation, motion, and mechanical and freehand drawing with ancient Greek catapult mechanics. Includes directions on how to both construct a template and develop the pattern for the icosahedrons. (CMK)

  20. Antiviral Defense Mechanisms in Honey Bees

    Science.gov (United States)

    Brutscher, Laura M.; Daughenbaugh, Katie F.; Flenniken, Michelle L.

    2015-01-01

    Honey bees are significant pollinators of agricultural crops and other important plant species. High annual losses of honey bee colonies in North America and in some parts of Europe have profound ecological and economic implications. Colony losses have been attributed to multiple factors including RNA viruses, thus understanding bee antiviral defense mechanisms may result in the development of strategies that mitigate colony losses. Honey bee antiviral defense mechanisms include RNA-interference, pathogen-associated molecular pattern (PAMP) triggered signal transduction cascades, and reactive oxygen species generation. However, the relative importance of these and other pathways is largely uncharacterized. Herein we review the current understanding of honey bee antiviral defense mechanisms and suggest important avenues for future investigation. PMID:26273564

  1. Development of Information Technology for Smart Defense

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Kyoil; Lee, So Yeon; Park, Sangjoon; Park, Jonghyun [ETRI, Daejeon (Korea, Republic of); Han, Sangcheol [KEIT, Seoul (Korea, Republic of)

    2014-03-15

    Recently, there has been demand for the convergence of IT (Information and communication Technologies, ICT) with defense, as has already been achieved in civilian fields such as healthcare and construction. It is expected that completely new and common requirements would emerge from the civilian and military domains and that the shape of war field would change rapidly. Many military scientists forecast that future wars would be network-centric and be based on C4I(Command, Control, Communication and Computer, Intelligence), ISR(Intelligence, Surveillance and Reconnaissance), and PGM(Precision Guided Munitions). For realizing the smart defense concept, IT should act as a baseline technology even for simulating a real combat field using virtual reality. In this paper, we propose the concept of IT-based smart defense with a focus on accurate detection in real and cyber wars, effective data communication, automated and unmanned operation, and modeling and simulation.

  2. Salt, chloride, bleach, and innate host defense.

    Science.gov (United States)

    Wang, Guoshun; Nauseef, William M

    2015-08-01

    Salt provides 2 life-essential elements: sodium and chlorine. Chloride, the ionic form of chlorine, derived exclusively from dietary absorption and constituting the most abundant anion in the human body, plays critical roles in many vital physiologic functions, from fluid retention and secretion to osmotic maintenance and pH balance. However, an often overlooked role of chloride is its function in innate host defense against infection. Chloride serves as a substrate for the generation of the potent microbicide chlorine bleach by stimulated neutrophils and also contributes to regulation of ionic homeostasis for optimal antimicrobial activity within phagosomes. An inadequate supply of chloride to phagocytes and their phagosomes, such as in CF disease and other chloride channel disorders, severely compromises host defense against infection. We provide an overview of the roles that chloride plays in normal innate immunity, highlighting specific links between defective chloride channel function and failures in host defense.

  3. Salt, chloride, bleach, and innate host defense

    Science.gov (United States)

    Wang, Guoshun; Nauseef, William M.

    2015-01-01

    Salt provides 2 life-essential elements: sodium and chlorine. Chloride, the ionic form of chlorine, derived exclusively from dietary absorption and constituting the most abundant anion in the human body, plays critical roles in many vital physiologic functions, from fluid retention and secretion to osmotic maintenance and pH balance. However, an often overlooked role of chloride is its function in innate host defense against infection. Chloride serves as a substrate for the generation of the potent microbicide chlorine bleach by stimulated neutrophils and also contributes to regulation of ionic homeostasis for optimal antimicrobial activity within phagosomes. An inadequate supply of chloride to phagocytes and their phagosomes, such as in CF disease and other chloride channel disorders, severely compromises host defense against infection. We provide an overview of the roles that chloride plays in normal innate immunity, highlighting specific links between defective chloride channel function and failures in host defense. PMID:26048979

  4. Strategic defense and the Western alliance

    Energy Technology Data Exchange (ETDEWEB)

    Lakoff, S.; Willoughby, R. (Univ. of California, CA (US))

    1987-01-01

    Strategic defense has again become a major item on the agenda of the Western Alliance. Revived by President Ronald Reagan in his Star Wars speech of March 1983, and implemented in his Strategic Defense Initiative, it has achieved renewed emphasis in military spending, in alliance research efforts, and in arms control negotiations. SDI is packaged in a way that makes it the largest single item in the Department of Defense's annual budget. It engages researchers in industrial and military laboratories on both sides of the Atlantic as well as in Japan and Israel. In the arms control negotiations now under way between the United States and the USSR, the conduct of this research and its implications for the strategic balance and the reduction of offensive weapons are critical considerations. The implications of this largely unexpected development are the subject of this book.

  5. Directed Energy Missions for Planetary Defense

    OpenAIRE

    Lubin, P.; Hughes, GB; Eskenazi, M; Kosmo, K.; Johansson, IE; Griswold, J., Ian,;Zhou, Hongjun,;Matison, Mikenzie,;Swanson, V., Ronald,;McIntosh, P., Lawrence,;Simon, I., Melvin,;Dahlquist, W., Frederick,; Pryor, M; O'Neill, H.; Meinhold, P.; Suen, J; J; Riley; Zhang, Q.; Walsh, K.; Melis, C.; Kangas, M

    2016-01-01

    Directed energy for planetary defense is now a viable option and is superior in many ways to other proposed technologies, being able to defend the Earth against all known threats. This paper presents basic ideas behind a directed energy planetary defense system that utilizes laser ablation of an asteroid to impart a deflecting force on the target. A conceptual philosophy called DE-STAR, which stands for Directed Energy System for Targeting of Asteroids and exploRation, is an orbiting stand-of...

  6. Macroevolutionary patterns of glucosinolate defense and tests of defense-escalation and resource availability hypotheses.

    Science.gov (United States)

    Cacho, N Ivalú; Kliebenstein, Daniel J; Strauss, Sharon Y

    2015-11-01

    We explored macroevolutionary patterns of plant chemical defense in Streptanthus (Brassicaceae), tested for evolutionary escalation of defense, as predicted by Ehrlich and Raven's plant-herbivore coevolutionary arms-race hypothesis, and tested whether species inhabiting low-resource or harsh environments invest more in defense, as predicted by the resource availability hypothesis (RAH). We conducted phylogenetically explicit analyses using glucosinolate profiles, soil nutrient analyses, and microhabitat bareness estimates across 30 species of Streptanthus inhabiting varied environments and soils. We found weak to moderate phylogenetic signal in glucosinolate classes and no signal in total glucosinolate production; a trend toward evolutionary de-escalation in the numbers and diversity of glucosinolates, accompanied by an evolutionary increase in the proportion of aliphatic glucosinolates; some support for the RAH relative to soil macronutrients, but not relative to serpentine soil use; and that the number of glucosinolates increases with microhabitat bareness, which is associated with increased herbivory and drought. Weak phylogenetic signal in chemical defense has been observed in other plant systems. A more holistic approach incorporating other forms of defense might be necessary to confidently reject escalation of defense. That defense increases with microhabitat bareness supports the hypothesis that habitat bareness is an underappreciated selective force on plants in harsh environments.

  7. Process- and patient-reported outcomes of a multifaceted medication adherence intervention for hypertensive patients in secondary care.

    Science.gov (United States)

    Hedegaard, Ulla; Hallas, Jesper; Ravn-Nielsen, Lene Vestergaard; Kjeldsen, Lene Juel

    2016-01-01

    tool was easy to use and helped them focus on addressing reasons for non-adherence. The mean total time spent by the pharmacist per patient was 2 h 14 min (SD 40 min). A pharmacist-led, multifaceted, tailored adherence intervention was feasible for identifying and addressing a wide range of potential adherence and lifestyle problems. Among the intervention procedures, MI was a central technique, applicable in most types of problems. The questionnaire showed relatively little value for identifying non-adherence. The intervention was well accepted both by the pharmacists and the patients, thereby increasing the likeliness of successful implementation in routine practice. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Adoption of workplaces and reach of employees for a multi-faceted intervention targeting low back pain among nurses' aides.

    Science.gov (United States)

    Rasmussen, Charlotte Diana Nørregaard; Larsen, Anne Konring; Holtermann, Andreas; Søgaard, Karen; Jørgensen, Marie Birk

    2014-05-01

    Workplace adoption and reach of health promotion are important, but generally poorly reported. The aim of this study is therefore to evaluate the adoption of workplaces (organizational level) and reach of employees (individual level) of a multi-faceted workplace health promotion and work environment intervention targeting low back pain among nurses' aides in elderly care. Percentage of adopters was calculated among eligible workplaces and differences between adopters and non-adopters were evaluated through workplace registrations and manager questionnaires from all eligible workplaces. From the adopted workplaces reach was calculated among eligible employees as the percentage who responded on a questionnaire. Responders were compared with non-responders using data from company registrations. Among responders, comparisons based on questionnaire data were performed between those consenting to participate in the intervention (consenters) and those not consenting to participate in the intervention (non-consenters). Comparisons were done using Student's t-test for the continuous variables, Fisher's exact test for dichotomous variables and the Pearson's chi(2) for categorical variables. Moreover odds ratios for non-responding and non-consenting were investigated with binary logistic regression analyses. The project was adopted by 44% of the offered workplaces. The main differences between adopters and non-adopters were that workplaces adopting the intervention had a more stable organization as well as a management with positive beliefs of the intervention's potential benefits. Of eligible employees, 71% responded on the questionnaire and 57% consented to participate. Non-responders and non-consenters did not differ from the responders and consenters on demographic factors and health. However, more non-responders and non-consenters were low skilled, worked less than 30 hours pr. week, and worked evening and nightshift compared to responders and consenters, respectively

  9. A multifaceted quality improvement intervention for CVD risk management in Australian primary healthcare: a protocol for a process evaluation.

    Science.gov (United States)

    Patel, Bindu; Patel, Anushka; Jan, Stephen; Usherwood, Tim; Harris, Mark; Panaretto, Katie; Zwar, Nicholas; Redfern, Julie; Jansen, Jesse; Doust, Jenny; Peiris, David

    2014-12-17

    Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Despite the widespread availability of evidence-based clinical guidelines and validated risk predication equations for prevention and management of CVD, their translation into routine practice is limited. We developed a multifaceted quality improvement intervention for CVD risk management which incorporates electronic decision support, patient risk communication tools, computerised audit and feedback tools, and monthly, peer-ranked performance feedback via a web portal. The intervention was implemented in a cluster randomised controlled trial in 60 primary healthcare services in Australia. Overall, there were improvements in risk factor recording and in prescribing of recommended treatments among under-treated individuals, but it is unclear how this intervention was used in practice and what factors promoted or hindered its use. This information is necessary to optimise intervention impact and maximally implement it in a post-trial context. In this study protocol, we outline our methods to conduct a theory-based, process evaluation of the intervention. Our aims are to understand how, why, and for whom the intervention produced the observed outcomes and to develop effective strategies for translation and dissemination. We will conduct four discrete but inter-related studies taking a mixed methods approach. Our quantitative studies will examine (1) the longer term effectiveness of the intervention post-trial, (2) patient and health service level correlates with trial outcomes, and (3) the health economic impact of implementing the intervention at scale. The qualitative studies will (1) identify healthcare provider perspectives on implementation barriers and enablers and (2) use video ethnography and patient semi-structured interviews to understand how cardiovascular risk is communicated in the doctor/patient interaction both with and without the use of intervention. We will also

  10. Patchy ‘coherence’: using normalization process theory to evaluate a multi-faceted shared decision making implementation program (MAGIC)

    Science.gov (United States)

    2013-01-01

    Background Implementing shared decision making into routine practice is proving difficult, despite considerable interest from policy-makers, and is far more complex than merely making decision support interventions available to patients. Few have reported successful implementation beyond research studies. MAking Good Decisions In Collaboration (MAGIC) is a multi-faceted implementation program, commissioned by The Health Foundation (UK), to examine how best to put shared decision making into routine practice. In this paper, we investigate healthcare professionals’ perspectives on implementing shared decision making during the MAGIC program, to examine the work required to implement shared decision making and to inform future efforts. Methods The MAGIC program approached implementation of shared decision making by initiating a range of interventions including: providing workshops; facilitating development of brief decision support tools (Option Grids); initiating a patient activation campaign (‘Ask 3 Questions’); gathering feedback using Decision Quality Measures; providing clinical leads meetings, learning events, and feedback sessions; and obtaining executive board level support. At 9 and 15 months (May and November 2011), two rounds of semi-structured interviews were conducted with healthcare professionals in three secondary care teams to explore views on the impact of these interventions. Interview data were coded by two reviewers using a framework derived from the Normalization Process Theory. Results A total of 54 interviews were completed with 31 healthcare professionals. Partial implementation of shared decision making could be explained using the four components of the Normalization Process Theory: ‘coherence,’ ‘cognitive participation,’ ‘collective action,’ and ‘reflexive monitoring.’ Shared decision making was integrated into routine practice when clinical teams shared coherent views of role and purpose (‘coherence’). Shared

  11. Berlyne Revisited: Evidence for the Multifaceted Nature of Hedonic Tone in the Appreciation of Paintings and Music

    Science.gov (United States)

    Marin, Manuela M.; Lampatz, Allegra; Wandl, Michaela; Leder, Helmut

    2016-01-01

    relationship between complexity and beauty followed an inverted-U curve, whereas the relationship between complexity and pleasantness was negative (rs = -0.26) and the one between complexity and liking positive (rs = 0.29). We relate our results to Berlyne’s theory and the latest findings in neuroaesthetics, proposing that future studies need to acknowledge the multifaceted nature of hedonic tone in esthetic experiences of artforms. PMID:27867350

  12. Patchy 'coherence': using normalization process theory to evaluate a multi-faceted shared decision making implementation program (MAGIC).

    Science.gov (United States)

    Lloyd, Amy; Joseph-Williams, Natalie; Edwards, Adrian; Rix, Andrew; Elwyn, Glyn

    2013-09-05

    Implementing shared decision making into routine practice is proving difficult, despite considerable interest from policy-makers, and is far more complex than merely making decision support interventions available to patients. Few have reported successful implementation beyond research studies. MAking Good Decisions In Collaboration (MAGIC) is a multi-faceted implementation program, commissioned by The Health Foundation (UK), to examine how best to put shared decision making into routine practice. In this paper, we investigate healthcare professionals' perspectives on implementing shared decision making during the MAGIC program, to examine the work required to implement shared decision making and to inform future efforts. The MAGIC program approached implementation of shared decision making by initiating a range of interventions including: providing workshops; facilitating development of brief decision support tools (Option Grids); initiating a patient activation campaign ('Ask 3 Questions'); gathering feedback using Decision Quality Measures; providing clinical leads meetings, learning events, and feedback sessions; and obtaining executive board level support. At 9 and 15 months (May and November 2011), two rounds of semi-structured interviews were conducted with healthcare professionals in three secondary care teams to explore views on the impact of these interventions. Interview data were coded by two reviewers using a framework derived from the Normalization Process Theory. A total of 54 interviews were completed with 31 healthcare professionals. Partial implementation of shared decision making could be explained using the four components of the Normalization Process Theory: 'coherence,' 'cognitive participation,' 'collective action,' and 'reflexive monitoring.' Shared decision making was integrated into routine practice when clinical teams shared coherent views of role and purpose ('coherence'). Shared decision making was facilitated when teams engaged in

  13. A multifaceted intervention to implement guidelines and improve admission paediatric care in Kenyan district hospitals: a cluster randomised trial.

    Directory of Open Access Journals (Sweden)

    Philip Ayieko

    2011-04-01

    Full Text Available BACKGROUND: In developing countries referral of severely ill children from primary care to district hospitals is common, but hospital care is often of poor quality. However, strategies to change multiple paediatric care practices in rural hospitals have rarely been evaluated. METHODS AND FINDINGS: This cluster randomized trial was conducted in eight rural Kenyan district hospitals, four of which were randomly assigned to a full intervention aimed at improving quality of clinical care (evidence-based guidelines, training, job aides, local facilitation, supervision, and face-to-face feedback; n  =  4 and the remaining four to control intervention (guidelines, didactic training, job aides, and written feedback; n  =  4. Prespecified structure, process, and outcome indicators were measured at baseline and during three and five 6-monthly surveys in control and intervention hospitals, respectively. Primary outcomes were process of care measures, assessed at 18 months postbaseline. In both groups performance improved from baseline. Completion of admission assessment tasks was higher in intervention sites at 18 months (mean  =  0.94 versus 0.65, adjusted difference 0.54 [95% confidence interval 0.05-0.29]. Uptake of guideline recommended therapeutic practices was also higher within intervention hospitals: adoption of once daily gentamicin (89.2% versus 74.4%; 17.1% [8.04%-26.1%]; loading dose quinine (91.9% versus 66.7%, 26.3% [-3.66% to 56.3%]; and adequate prescriptions of intravenous fluids for severe dehydration (67.2% versus 40.6%; 29.9% [10.9%-48.9%]. The proportion of children receiving inappropriate doses of drugs in intervention hospitals was lower (quinine dose >40 mg/kg/day; 1.0% versus 7.5%; -6.5% [-12.9% to 0.20%], and inadequate gentamicin dose (2.2% versus 9.0%; -6.8% [-11.9% to -1.6%]. CONCLUSIONS: Specific efforts are needed to improve hospital care in developing countries. A full, multifaceted intervention was associated

  14. Transcriptomic and Metabolomic Analysis Revealed Multifaceted Effects of Phage Protein Gp70.1 on Pseudomonas aeruginosa

    Science.gov (United States)

    Zhao, Xia; Chen, Canhuang; Jiang, Xingyu; Shen, Wei; Huang, Guangtao; Le, Shuai; Lu, Shuguang; Zou, Lingyun; Ni, Qingshan; Li, Ming; Zhao, Yan; Wang, Jing; Rao, Xiancai; Hu, Fuquan; Tan, Yinling

    2016-01-01

    The impact of phage infection on the host cell is severe. In order to take over the cellular machinery, some phage proteins were produced to shut off the host biosynthesis early in the phage infection. The discovery and identification of these phage-derived inhibitors have a significant prospect of application in antibacterial treatment. This work presented a phage protein, gp70.1, with non-specific inhibitory effects on Pseudomonas aeruginosa and Escherichia coli. Gp70.1 was encoded by early gene – orf 70.1 from P. aeruginosa phage PaP3. The P. aeruginosa with a plasmid encoding gp70.1 showed with delayed growth and had the appearance of a small colony. The combination of multifaceted analysis including microarray-based transcriptomic analysis, RT-qPCR, nuclear magnetic resonance (NMR) spectroscopy-based metabolomics and phenotype experiments were performed to investigate the effects of gp70.1 on P. aeruginosa. A total of 178 genes of P. aeruginosa mainly involved in extracellular function and metabolism were differentially expressed in the presence of gp70.1 at three examined time points. Furthermore, our results indicated that gp70.1 had an extensive impact on the extracellular phenotype of P. aeruginosa, such as motility, pyocyanin, extracellular protease, polysaccharide, and cellulase. For the metabolism of P. aeruginosa, the main effect of gp70.1 was the reduction of amino acid consumption. Finally, the RNA polymerase sigma factor RpoS was identified as a potential cellular target of gp70.1. Gp70.1 was the first bacterial inhibitor identified from Pseudomonas aeruginosa phage PaP3. It was also the first phage protein that interacted with the global regulator RpoS of bacteria. Our results indicated the potential value of gp70.1 in antibacterial applications. This study preliminarily revealed the biological function of gp70.1 and provided a reference for the study of other phage genes sharing similarities with orf70.1. PMID:27725812

  15. Evaluation of a multifaceted social marketing campaign to increase awareness of and screening for oral cancer in African Americans.

    Science.gov (United States)

    Jedele, J M; Ismail, A I

    2010-08-01

    newspaper ads were printed; and 242 education sessions were conducted. The hotline received 1783 calls. The majority of callers reported that their call was prompted by a radio ad (57%). The clinic screened 1020 adults and referred 78 for further examination. Three cancers, two precancers, and 12 benign tumors were detected. The total cost associated with the campaign and toll-free hotline was $795,898. A multifaceted social marketing campaign including radio ads, billboards, and education sessions can effectively target a high-risk population and that given an outlet could result in a significant number of people getting screened at a relatively low cost.

  16. A multi-faceted knowledge translation approach to support persons with stroke and cognitive impairment: evaluation protocol.

    Science.gov (United States)

    McEwen, Sara E; Donald, Michelle; Dawson, Deirdre; Egan, Mary Y; Hunt, Anne; Quant, Sylvia; Runions, Sharron; Linkewich, Elizabeth

    2015-11-05

    Patients with cognitive impairments following a stroke are often denied access to inpatient rehabilitation. The few patients with cognitive impairment admitted to rehabilitation generally receive services based on outdated impairment-reduction models, rather than recommended function-based approaches. Both reduced access to rehabilitation and the knowledge-to-practice gap stem from a reported lack of skills and knowledge regarding cognitive rehabilitation on the part of inpatient rehabilitation team members. To address these issues, a multi-faceted knowledge translation (KT) initiative will be implemented and evaluated. It will be targeted specifically at the inter-professional application of the cognitive orientation to daily occupational performance (CO-OP). CO-OP training combined with KT support is called CO-OP KT. The long-term objective of CO-OP KT is to optimize functional outcomes for individuals with stroke and cognitive impairments. Three research questions are posed: 1. Is the implementation of CO-OP KT associated with a change in the proportion of patients with cognitive impairment following a stroke accepted to inpatient rehabilitation? 2. Is the implementation of CO-OP KT associated with a change in rehabilitation clinicians' practice, knowledge, and self-efficacy related to implementing the CO-OP approach, immediately following and 1 year later? 3. Is CO-OP KT associated with changes in activity, participation, and self-efficacy to perform daily activities in patients with cognitive impairment following stroke at discharge from inpatient rehabilitation and at 1-, 3-, and 6-month follow-ups? Three interrelated studies will be conducted. Study 1 will be a quasi-experimental, interrupted time series design measuring monthly summaries of stroke unit level data. Study 2, which relates to changes in health care professional practice and self-efficacy, will be a single group pre-post evaluation design incorporating chart audits and a self-report survey

  17. Berlyne revisited: Evidence for the multifaceted nature of hedonic tone in the appreciation of paintings and music

    Directory of Open Access Journals (Sweden)

    Manuela Maria Marin

    2016-11-01

    relationship between complexity and beauty followed an inverted-U curve, whereas the relationship between complexity and pleasantness was negative (rs = -.26 and the one between complexity and liking positive (rs = .29. We relate our results to Berlyne’s theory and to the latest findings in neuroaesthetics, proposing that future studies need to acknowledge the multifaceted nature of hedonic tone in aesthetic experiences of artforms.

  18. Evidence for habitual and goal-directed behavior following devaluation of cocaine: a multifaceted interpretation of relapse.

    Directory of Open Access Journals (Sweden)

    David H Root

    with the cocaine infusion. Non-discriminative stimulus cues were weak correlates of the infusion, which failed to evoke a representation of the value of cocaine and led to habitual behavior. However, the discriminative stimulus-nearly perfectly correlated with the infusion-likely evoked a representation of the value of the infusion and led to goal-directed behavior. These data indicate that abstinent cue-induced responding is multifaceted, dynamically engendering habitual or goal-directed behavior. Moreover, since goal-directed behavior terminated habitual behavior during testing, therapeutic approaches aimed at reducing the perceived value of cocaine in addicted individuals may reduce the capacity of cues to induce relapse.

  19. The Full Costs of Ballistic Missile Defense

    Science.gov (United States)

    2003-01-01

    Krepinovich, “Defense Transformation,” and Paul Wolfowitz , “Transformation,” Prepared testimony, Senate Armed Services Committee, April 9, 2002...Massive Cash Infusion,” Aviation Week and Space Technology, April 22, 2002.9 Matthew L. Wald , “White House Cuts 93% of Funds Sought to Guard Atomic Arms

  20. Defense Acquisitions: Assessments of Selected Weapon Programs

    Science.gov (United States)

    2013-03-01

    Radios, Joint Land Attack Cruise Missile Defense Elevated Netter Sensor System, C-130 Avionics Modernization Program, or National Polar-orbiting...investigation of hypoxia-like physiological symptoms experienced by some F- 22A pilots, an issue identified as being significant starting in 2008 and

  1. The fragility of the Brazilian Defense Ministry

    Directory of Open Access Journals (Sweden)

    Jorge Zaverucha

    2006-01-01

    Full Text Available The present article presents different phases that the Brazilian Defense Ministry has passed through, since its inception during Fernando Henrique Cardoso's second presidential term (1999-2002 until the current administration of Luís Inácio Lula da Silva (2003-2006, under its respective ministers of Defense. It has been seen as one of the important stages in the re-constitutionalization of the country, insofar as it establishes the submission of Armed Forces commanders to a civilian minister, and although some analysts have considered that such submission is actually achieved, we point here to the military resistance and insubordination to civil power that are the result of an authoritarian legacy. To the extent that the Ministry of Defense is unable to implement its own policies in which the military would be required to follow civilian guidance, this article concludes with considerations on the civil Defense Ministry's political and institutional fragility vis-a-vis military command. The latter has been able to retain high levels of decision making autonomy in its relationship to the Ministry and its structure.

  2. Techniques for Combined Arms for Air Defense

    Science.gov (United States)

    2016-07-29

    defense systems. Planning must focus on current threat intelligence capitalizing on suspected and reported enemy information that may shape near term...over short distances as attack and transport platforms because they have exceptional low altitude flight capabilities. These aircraft are easily masked...BALLISTIC MISSILES (TBM) What are the capabilities of threat TBM systems regarding:  Performance ( flight time, speed, trajectory and launch

  3. Enhancing Air Base Defense Through Joint Doctrine

    Science.gov (United States)

    2009-01-01

    Warfare, 258. 40 Tse-Tung, Mao Tse-Tung on Guerrilla Warfare, 27. 41 Maj David P. Briar , USAF, Sharpening the Eagle’s Talons: Assessing Air Base Defense...and Contingency Operations Doctrine 1942-1976, Washington, D.C.: Center ofMilitary History U.S. Army, 2006 (143) Briar , Maj David P., USAF, Sharpening

  4. Preemptive strikes: Fear, hope, and defensive aggression.

    Science.gov (United States)

    Halevy, Nir

    2017-02-01

    Preemptive strikes are costly and harmful. Existing models of defensive aggression focus narrowly on the role fear plays in motivating preemptive strikes. Theoretically integrating the literatures on conflict, decision making, and emotion, the current research investigated how specific emotions associated with certainty or uncertainty, including fear, anger, disgust, hope, and happiness, influence preemptive strikes. Study 1 demonstrated that hope negatively predicts defensive exits from relationships in choice dilemmas. Studies 2 and 3 experimentally manipulated risk of being attacked in an incentivized, interactive decision making task-the Preemptive Strike Game. Risk of being attacked fueled preemptive strikes; reduced feelings of hope partially mediated this effect in Study 3. Studies 4 and 5 investigated preemptive strikes under uncertainty (rather than risk). In Study 4, reasoning about the factors that make one trustful of others curbed preemptive strikes; cogitating about the factors that underlie discrete emotions, however, did not influence defensive aggression. Study 5 demonstrated that the valence and uncertainty appraisals of incidental emotions interact in shaping preemptive strikes. Specifically, recalling an autobiographical emotional experience that produced hope significantly decreased attack rates relative to fear, happiness, and a control condition. Fear, anger, disgust, and happiness were either unrelated to preemptive strikes or showed inconsistent relationships with preemptive strikes across the 5 studies. These findings shed light on how emotions shape defensive aggression, advance knowledge on strategic choice under risk and uncertainty, and demonstrate hope's positive effects on social interactions and relationships. (PsycINFO Database Record

  5. Student Papers on Strategic Defense Initiative.

    Science.gov (United States)

    1985-01-01

    force". The Army’s recent emphasis on maneuver and mobil - ity, and the employment of smaller units, demonstrates the utility of this doctrine...to forgo the use of defensive space systems, since some of the techonology now investigated could at least pro- tect missile sites, and make the

  6. 75 FR 32416 - Defense Science Board

    Science.gov (United States)

    2010-06-08

    ... Systems and Assets to Electromagnetic Pulse (EMP) and other Nuclear Weapons Effects will meet in closed... discuss presentations on: findings and recommendations of the Congressional EMP Commission, the Defense...; implementation to date of DoD Instruction 3150.09; the SECDEF 2009 Report to Congress on EMP Survivability;...

  7. Defense Advanced Research Projects Agency Strategic Plan

    Science.gov (United States)

    2007-02-01

    Autonomous Language Exploitation ...................................................................... 33 Figure 35: Bio-inspired "Big Dog" quadruped robot is... Acqusition , Technology and the United States, while creating Logistics Kenneth J. Krieg technological surprise for our • Under Secretaryof Defense for...working to maintain our global lead in this technology (Section 3.7). " Real-Time Accurate Language Translation: real-time machine language

  8. Cost Effective Regional Ballistic Missile Defense

    Science.gov (United States)

    2016-02-16

    Defense Agency, Huntsville, AL; Chief, Materiel Fielding Team ( Automotive ), Materiel Fielding and Training Directorate, TACOM Life Cycle Management...Executive Office Ground Combat Systems, Detroit Arsenal, Michigan; Training With Industry Officer, EADS North America, Huntsville, Alabama; and Product...identify the ways and means to counter this imbalance or risk future erosion of our military effectiveness, diminished allied confidence, and unnecessarily

  9. Carp erythrodermatitis: host defense-pathogen interaction.

    NARCIS (Netherlands)

    Pourreau, C.N.

    1990-01-01

    The outcome of a bacterial infection depends on the interaction between pathogen and host. The ability of the microbe to survive in the host depends on its invasive potential (i.e. spreading and multiplication), and its ability to obtain essential nutrients and to resist the host's defense syste

  10. Defense Science and Technology Success Stories

    Science.gov (United States)

    2007-01-01

    program. POC: Mr. Paul Koskey, MDA/ DVI , 703-882-6154 Year: FY 2006/2007 Fiber Grating Sensor for Damage Assessment MISSILE DEFENSE AGENCY (MDA) 43...sulfur, these microorganisms remove a potentially fouling precipitate from the anode. Collective activity of the biofilm and continuous flux of fuel by

  11. Rigorous Cyberspace Defense Expert Training Moves Forward

    Science.gov (United States)

    2012-09-01

    planners to integrate computer network opera- tions into the commander’s opera- tions down to the tactical edge. Aspects of CND by themselves are...also a graduate of the first 255S class October 2010. ACRONYM QuickScan CND - Computer network defense CNO - Computer network operations CTF

  12. Schools Enlisting Defense Industry to Boost STEM

    Science.gov (United States)

    Trotter, Andrew

    2008-01-01

    Defense contractors Northrop Grumman Corp. and Lockheed Martin Corp. are joining forces in an innovative partnership to develop high-tech simulations to boost STEM--or science, technology, engineering, and mathematics--education in the Baltimore County schools. The Baltimore County partnership includes the local operations of two major military…

  13. Host Defense against Opportunist Microorganisms Following Trauma.

    Science.gov (United States)

    1988-06-30

    02ELEMENT NO. NO.3S162 jNO. ACESSION NO. Frdeic, arlnd210150262772A 772A874 AA280 11. TITLF (Include Securrty Classification) (U) Host Defense Against...copy Dean School of Medicine Uniformed Services University of the Hlealth Sciences 4301 Jones Bridge Road’ Bethesda, MD 20814-4799 1 copy Commandant

  14. Defense Acquisition Transformation: Report to Congress

    Science.gov (United States)

    2007-07-25

    acquisition and financial databases . The emphasis is on data integrity in a net-centric, authoritative environment and comprehensive, transparent...resources R&E planning documents, financial databases , and other R&E resources Defense Acquisition Management Information Retrieval (DAMIR): Leverages

  15. Non-Traditional Commercial Defense Contractors

    Science.gov (United States)

    2013-11-01

    have access to shared virtual workspaces and overnight shipping. Virtual tools improve communication among researchers both across the campus and...reports. Retrieved from http://www.fas.org/man/dod-101/sys/ smart /ppcp97c1.htm Office of the Secretary of Defense (OSD). (2002, April 5). Mandatory

  16. The DDN (Defense Data Network) Course,

    Science.gov (United States)

    1986-04-01

    Endtc Proceso H~~~% - ot-opue 5 - 4a 5) Technical Overview of the Defense Data Network a) Design Criteria -= . -%** Low risk, cost effective system that...SOFTWARE: VMS/Ultnx/TOPS-20 Operating System BACKGROUND: Until this past year Digital promoted the use of "DECnet" exclusively , its proprietary networking

  17. The equal effectiveness of different defensive strategies

    Science.gov (United States)

    Zhang, Shuang; Zhang, Yuxin; Ma, Keming

    2015-01-01

    Plants have evolved a variety of defensive strategies to resist herbivory, but at the interspecific level, the relative effectiveness of these strategies has been poorly evaluated. In this study, we compared the level of herbivory between species that depend on ants as indirect defenders and species that rely primarily on their own direct defenses. Using a dataset of 871 species and 1,405 data points, we found that in general, ant-associated species had levels of herbivory equal to those of species that are unattractive to ants; the pattern was unaffected by plant life form, climate and phylogenetic relationships between species. Interestingly, species that offer both food and nesting spaces for ants suffered significantly lower herbivory compared to species that offer either food or nesting spaces only or no reward for ants. A negative relationship between herbivory and latitude was detected, but the pattern can be changed by ants. These findings suggest that, at the interspecific level, the effectiveness of different defensive strategies may be equal. Considering the effects of herbivory on plant performance and fitness, the equal effectiveness of different defensive strategies may play an important role in the coexistence of various species at the community scale. PMID:26267426

  18. A multifaceted GABAA receptor modulator: Functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)

    DEFF Research Database (Denmark)

    Hammer, Harriet; Bader, Benjamin M.; Ehnert, C

    2015-01-01

    In the present study, we have elucidated the functional characteristics and mechanism of action of methaqualone (2-methyl-3-o-tolyl-4(3H)-quinazolinone, Quaalude), an infamous sedative-hypnotic and recreational drug from the 1960s-1970s. Methaqualone was demonstrated to be a positive allosteric...... arising from doses producing significant in vivo effects in assays for locomotion and anticonvulsant activity correlated fairly well with its potencies as a modulator at the recombinant GABAARs. Hence, we propose that the multifaceted functional properties exhibited by methaqualone at GABAARs give rise...... to its effects as a therapeutic and recreational drug....

  19. The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Scott J. Sherman

    2010-08-01

    Full Text Available Over the last few decades, vascular endothelial growth factor (VEGF and pigment epithelium-derived factor (PEDF have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, and have been best studied for their effects in cardiology and cancer biology. Recent work with the two factors indicates that the activity of one growth factor is often directly related to the action of the other. Their respective neuroprotective effects, in particular, raise important questions regarding the treatment of neurodegenerative disorders, including Parkinson’s disease.

  20. THE CONCEPT OF "SMART DEFENSE" IN THE CONTEXT OF AN EFFICIENT DEFENSE PLANNING

    Directory of Open Access Journals (Sweden)

    Teodor FRUNZETI

    2012-01-01

    Full Text Available The international security environment is currently undergoing a series of fundamental changes becoming increasingly complex. Consequently, international actors need to find innovative ways to manage security and defense. The global financial and economic crisis has had a strong impact on military budgets, making it necessary for states and regional and international organizations concerned with such issues to streamline their defense planning and the more so because, in addition to the already consecrated risks and security threats, there are also new challenges. The concepts of “pooling and sharing” and “smart defense” have become, in this context, increasingly popular generating new initiatives in defense planning. However, despite some successes in this regard and their presentation as ideal solutions for managing defense in the current context, these concepts involve a number of difficulties to overcome that sometimes may translate into strategic political military and even economic disadvantages.

  1. Is flood defense changing in nature? Shifts in the flood defense strategy in six European countries

    National Research Council Canada - National Science Library

    Gralepois, Mathilde; Larrue, Corinne; Wiering, Mark; Crabbé, Ann; Tapsell, Sue; Mees, Hannelore; Ek, Kristina; Szwed, Malgorzata

    2016-01-01

    ... (Belgium, England, France, the Netherlands, Poland, and Sweden). The evolutions within the defense strategy over the last 30 years have been analyzed with the help of three mainstream institutional theories...

  2. Department of Defense Chemical and Biological Defense Program. Volume 2: FY2002-2004 Performance Plan

    Science.gov (United States)

    2003-04-01

    Complete research studies for the development of vaccine candidates for WEE virus. Defense Advanced Research Projects Agency (DARPA) Program...encephalitic alphaviruses. Continue research for the development of vaccine candidates for EEE virus infection. Test promising vaccine candidates for

  3. Reinventing the Arsenal: Defense-Industrial Adaptation in Small States

    National Research Council Canada - National Science Library

    Marc R Devore

    2016-01-01

    .... forced governments to reevaluate their defense-industrial policies. In each case, governments abandoned the pursuit of defense-industrial self-sufficiency and adopted export-dependent defenseindustrial policies...

  4. Defense Centers of Excellence for Psychological Health & Traumatic Brain Injury

    Science.gov (United States)

    ... Sign up Search: Defense Centers of Excellence For Psychological Health & Traumatic Brain Injury U.S. Department of Defense ... Reports Program Evaluation DoD/VA PH & TBI Registry Psychological Health About Psychological Health Psychological Health Resources About ...

  5. How Single Is “Single” - Some Pragmatic Reflections on Single Versus Multifaceted Interventions to Facilitate Implementation; Comment on “Translating Evidence Into Healthcare Policy and Practice: Single Versus Multifaceted Implementation Strategies – Is There a Simple Answer to a Complex Question?”

    Directory of Open Access Journals (Sweden)

    Ann Catrine Eldh

    2015-10-01

    Full Text Available An earlier overview of systematic reviews and a subsequent editorial on single-component versus multifaceted interventions to promote knowledge translation (KT highlight complex issues in implementation science. In this supplemented commentary, further aspects are in focus; we propose examples from (KT studies probing the issue of single interventions. A main point is that defining what is a single and what is a multifaceted intervention can be ambiguous, depending on how the intervention is conceived. Further, we suggest additional perspectives in terms of strategies to facilitate implementation. More specifically, we argue for a need to depict not only what activities are done in implementation interventions, but to unpack functions in particular contexts, in order to support the progress of implementation science.

  6. Defense Technology Objectives of the Joint Warfighting Science and Technology and Defense Technology Area Plan.

    Science.gov (United States)

    1996-05-01

    occlusion , multipath etc.) through the use of inertial measurement systems (Interferometric Fiber Optic Gyro, Dynamically Tuned Gyro) and will...management systems provide mobile and semi- mobile assets (e.g., Abrams, Theater Missile Defense - TMD ) with low cost, low burden survivability...technology for development of an operational high energy Airborne Laser (ABL) for Theater Missile Defense ( TMD ). Address risk reduction issues for develop

  7. Defense Acquisitions: Assessment of Institute for Defense Analyses C-130 Avionics Modernization Program Analysis

    Science.gov (United States)

    2014-05-29

    Page 1 GAO-14-547R C-130 Avionics Modernization Program 441 G St. N.W. Washington, DC 20548 May 29, 2014...Congressional Committees Defense Acquisitions: Assessment of Institute for Defense Analyses’ C-130 Avionics Modernization Program Analysis The Air...Force’s C-130 Avionics Modernization Program (AMP), which entered development in 2001, was to standardize and upgrade the cockpit and avionics for

  8. The US-Japan Alliance: Sharing the Burden of Defense

    Science.gov (United States)

    1983-01-01

    expenditures to GNP. Japan Is also far down the list in defense spending per capita, behind nations such as Sweden, Australia, and Canada. Table 1.2 compares...TABLES Figures 1.1 Trends in Japanese Defense Spending ................. 14 Tables 1.1 Defense Expenditures of Major Countries ............... 12 1.2...Percentage Breakdown of Japanese Defense Expenditures by Category, FY 1977-1981 ............ 40 3.3 Disposition of US Forces in Japan

  9. 75 FR 9588 - Defense Intelligence Agency Advisory Board; Closed Meeting

    Science.gov (United States)

    2010-03-03

    ... Office of the Secretary Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice of closed meeting. SUMMARY: Pursuant to the provisions of subsection... hereby given that the Defense Intelligence Agency Advisory Board, will meet on March 22 and 23, 2010....

  10. 76 FR 20336 - Defense Audit Advisory Committee (DAAC)

    Science.gov (United States)

    2011-04-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary Defense Audit Advisory Committee (DAAC) AGENCY: Under Secretary of Defense... (5 U.S.C., Appendix, as amended), the Government in the Sunshine Act of 1976 (5 U.S.C. 552b, as...

  11. Trusted Defense Microelectronics: Future Access and Capabilities Are Uncertain

    Science.gov (United States)

    2015-10-28

    TRUSTED DEFENSE MICROELECTRONICS Future Access and Capabilities Are Uncertain Statement of Marie A. Mak...1. REPORT DATE OCT 2015 2. REPORT TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Trusted Defense Microelectronics ...House of Representatives October 2015 TRUSTED DEFENSE MICROELECTRONICS Future Access and Capabilities Are Uncertain Why GAO Did This Study DOD’s

  12. Urban Youth, Fear of Crime, and Resulting Defensive Actions.

    Science.gov (United States)

    Williams, J. Sherwood; And Others

    1994-01-01

    Used data from 1,775 urban youth collected in 1986 to examine fear of crime and defensive actions taken by youth. Results revealed that only 11% reported having taken no defensive actions as result of fear of crime. Nearly three-fifths took precaution of having escort at night. Learning self-defense techniques was reported by 19%; 10% indicated…

  13. Department of Defense DOD Freedom of Information Act Program

    Science.gov (United States)

    1998-09-01

    processor in previous example. WHITE, Sally 400 .2 Processed FOIA’s part-time while working as paralegal in General Counsel’s Office. PETERS, 1,000 .5 Part...Under Secretary of Defense (Industrial Affairs & Installations) Assistant to the Secretary of Defense (Nuclear, Chemical & Biological Defense Programs

  14. 76 FR 5729 - Department of Defense Personnel Security Program (PSP)

    Science.gov (United States)

    2011-02-02

    ... of the Secretary 32 CFR Part 156 Department of Defense Personnel Security Program (PSP) AGENCY... for the Department of Defense (DoD) Personnel Security Program (PSP) in accordance with the provisions... Department of Defense Directive (DoDD) 5200.2, Personnel Security Program (PSP), codified at 32 CFR 156,...

  15. 75 FR 40857 - Webinar About Advanced Defense Technologies RFP

    Science.gov (United States)

    2010-07-14

    ... ADMINISTRATION Webinar About Advanced Defense Technologies RFP AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of open webinar meeting to discuss Advanced Defense Technologies (ADT) Request for... webinar it is hosting to answer questions from potential Offerors about the Advanced Defense...

  16. 77 FR 46653 - Defense Logistics Agency Privacy Program

    Science.gov (United States)

    2012-08-06

    ... of the Secretary 32 CFR Part 323 RIN 0790-AI86 Defense Logistics Agency Privacy Program AGENCY: Defense Logistics Agency, DoD. ACTION: Proposed rule with request for comments. SUMMARY: The Defense Logistics Agency (DLA) is proposing to amend the DLA Privacy Program Regulation. The DLA Privacy...

  17. Children's Use of Defenses and Self-Esteem Management.

    Science.gov (United States)

    Hay, Deborah

    Children's use of defenses to maintain or enhance self-esteem was investigated. Attention was given to four questions: Do children with different levels of self-esteem differ in (1) the frequency with which they employ defenses? (2) kinds of emotions they defend against? (3) the kinds of social situations which elicit their defensive responses?…

  18. 32 CFR 644.333 - Screening for defense needs.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Screening for defense needs. 644.333 Section 644... Screening for defense needs. Real property which becomes excess to the needs of any element of the Army or... the property is excess to the needs of the using command, without screening for other requirements....

  19. Defense Institution Reform Initiative Program Elements Need to Be Defined

    Science.gov (United States)

    2012-11-09

    DSCA Defense Security Cooperation Agency DASD PSO Deputy Assistant Secretary of Defense for MoDA Ministry of Defense Advisors Partnership Strategy...to the USD(P) Chief of Staff. 2 According to the DASD PSO, his office provided program management for the MoDA Program. However, according to a DASD

  20. Takeover defenses and IPO firm value in the Netherlands

    NARCIS (Netherlands)

    Roosenboom, P.; van der Goot, L.R.T.

    2003-01-01

    The central question of this study involves the relation between the use of takeover defenses and IPO firm value. We report that management frequently uses takeover defenses before taking the firm public. The use of takeover defenses is primarily motivated by managerial entrenchment. IPO investors

  1. Takeover defenses and IPO firm value in the Netherlands

    NARCIS (Netherlands)

    P.G.J. Roosenboom (Peter); T. van der Goot

    2003-01-01

    textabstractThe central question of this study involves the relation between the use of takeover defenses and IPO firm value. We report that management frequently uses takeover defenses before taking the firm public. The use of takeover defenses is primarily motivated by managerial entrenchment. IPO

  2. Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial

    Science.gov (United States)

    Simpson, Sharon A; Dunstan, Frank; Rollnick, Stephen; Cohen, David; Gillespie, David; Evans, Meirion R; health, senior lecturer in epidemiology and public; Alam, M Fasihul; Bekkers, Marie-Jet; Evans, John; Moore, Laurence; Howe, Robin; Hayes, Jamie; Hare, Monika; Hood, Kerenza

    2012-01-01

    Objective To evaluate the effectiveness and costs of a multifaceted flexible educational programme aimed at reducing antibiotic dispensing at the practice level in primary care. Design Randomised controlled trial with general practices as the unit of randomisation and analysis. Clinicians and researchers were blinded to group allocation until after randomisation. Setting 68 general practices with about 480 000 patients in Wales, United Kingdom. Participants 34 practices were randomised to receive the educational programme and 34 practices to be controls. 139 clinicians from the intervention practices and 124 from control practices had agreed to participate before randomisation. Practice level data covering all the clinicians in the 68 practices were analysed. Interventions Intervention practices followed the Stemming the Tide of Antibiotic Resistance (STAR) educational programme, which included a practice based seminar reflecting on the practices’ own dispensing and resistance data, online educational elements, and practising consulting skills in routine care. Control practices provided usual care. Main outcome measures Total numbers of oral antibiotic items dispensed for all causes per 1000 practice patients in the year after the intervention, adjusted for the previous year’s dispensing. Secondary outcomes included reconsultations, admissions to hospital for selected causes, and costs. Results The rate of oral antibiotic dispensing (items per 1000 registered patients) decreased by 14.1 in the intervention group but increased by 12.1 in the control group, a net difference of 26.1. After adjustment for baseline dispensing rate, this amounted to a 4.2% (95% confidence interval 0.6% to 7.7%) reduction in total oral antibiotic dispensing for the year in the intervention group relative to the control group (P=0.02). Reductions were found for all classes of antibiotics other than penicillinase-resistant penicillins but were largest and significant individually for

  3. 77 FR 32952 - Defense Intelligence Agency National Intelligence University Board of Visitors Closed Meeting

    Science.gov (United States)

    2012-06-04

    ... of the Secretary Defense Intelligence Agency National Intelligence University Board of Visitors Closed Meeting AGENCY: Department of Defense, Defense Intelligence Agency, National Intelligence... a closed meeting of the Defense Intelligence Agency National Intelligence University Board...

  4. The Defense Science Board 1999 Summer Study Task Force on 21st Century Defense Technology Strategies. Volume 1

    Science.gov (United States)

    2016-06-07

    Study Task Force On 21ST Century Defense Technology Strategies Volume 1 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR...3. Defense Technology Strategy and Management PART 4. Strategic Agility PART 5. Analysis and Quantitative Results iii PREFACE The Defense Science...Board (DSB) 1999 Summer Study Task Force on 21st Century Defense Technology Strategies continues a series of studies that have examined key challenges

  5. Intelligent systems for strategic power infrastructure defense

    Science.gov (United States)

    Jung, Ju-Hwan

    A fault or disturbance in a power system can be severe due to the sources of vulnerability such as human errors, protection and control system failures, a failure of communication networks to deliver critical control signals, and market and load uncertainties. There have been several catastrophic failures resulting from disturbances involving the sources of vulnerability while power systems are designed to withstand disturbances or faults. To avoid catastrophic failures or minimize the impact of a disturbance(s), the state of the power system has to be analyzed correctly and preventive or corrective self-healing control actions have to be deployed. This dissertation addresses two aspects of power systems: Defense system and diagnosis, both concerned with the power system analysis and operation during events involving faults or disturbances. This study is intended to develop a defense system that is able to assess power system vulnerability and to perform self-healing control actions based on the system-wide analysis. In order to meet the requirements of the system-wide analysis, the defense system is designed with multi-agent system technologies. Since power systems are dynamic and uncertain the self-healing control actions need to be adaptive. This study applies the reinforcement learning technique to provide a theoretical basis for adaptation. One of the important issues in adaptation is the convergence of the learning algorithm. An appropriate convergence criterion is derived and an application with a load-shedding scheme is demonstrated in this study. This dissertation also demonstrates the feasibility of the defense system and self-healing control actions through multi-agent system technologies. The other subject of this research is to investigate the methodology for on-line fault diagnosis using the information from Sequence-of-Events Recorders (SER). The proposed multiple-hypothesis analysis generates one or more hypothetical fault scenarios to interpret the

  6. The value of a multi-faceted climate change vulnerability assessment to managing protected lands: lessons from a case study in Point Reyes National Seashore.

    Science.gov (United States)

    Hameed, Sarah O; Holzer, Katie A; Doerr, Angee N; Baty, Jill H; Schwartz, Mark W

    2013-05-30

    Managing protected areas in the face of an uncertain future climate poses serious challenges. There are currently a variety of predictive and analytical methods for assessing future climates and biological responses to the changes, but an assessment produced by any one of these methods is necessarily limited in scope. When making management decisions, therefore, it is beneficial to have information from a variety of sources and analytical methods, and to compare the agreements and discrepancies among them. Based on existing climate change vulnerability assessment frameworks in the literature, we developed a multi-faceted climate change vulnerability assessment at the biological community level comprised of: a) expert judgment, b) predictive vegetation mapping, c) predictive geophysical mapping, and d) species-specific evaluations. We wrote a climate change vulnerability assessment for Point Reyes National Seashore and evaluated the usefulness of each facet, alone and in concert. We found that the facets were complementary and that each one was useful to inform some management goals; we also found that expert judgment was the most widely applicable and flexible assessment method. We believe that this multi-faceted framework can be employed in other protected areas to facilitate management decisions under a changing and uncertain future climate. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Getting evidence-based pressure ulcer prevention into practice: a multi-faceted unit-tailored intervention in a hospital setting.

    Science.gov (United States)

    Sving, Eva; Högman, Marieann; Mamhidir, Anna-Greta; Gunningberg, Lena

    2016-10-01

    The aim of the study was to evaluate whether a multi-faceted, unit-tailored intervention using evidenced-based pressure ulcer prevention affects (i) the performance of pressure ulcer prevention, (ii) the prevalence of pressure ulcers and (iii) knowledge and attitudes concerning pressure ulcer prevention among registered and assistant nurses. A quasi-experimental, clustered pre- and post-test design was used. Five units at a hospital setting were included. The intervention was based on the PARIHS framework and included a multi-professional team, training and repeated quality measurements. An established methodology was used to evaluate the prevalence and prevention of pressure ulcers. Nurses' knowledge and attitudes were evaluated using a validated questionnaire. A total of 506 patients were included, of whom 105 patients had a risk to develop pressure ulcer. More patients were provided pressure ulcer prevention care (P = 0·001) and more prevention care was given to each patient (P = 0·021) after the intervention. Corresponding results were shown in the group of patients assessed as being at risk for developing pressure ulcers. Nurses' knowledge about pressure ulcer prevention increased (P pressure ulcer prevention remained high between pre- and post-test surveys. This multi-faceted unit-tailored intervention affected pressure ulcer prevention. Facilitation and repeated quality measurement together with constructed feedback of results seemed to be the most important factor for pressure ulcer prevention.

  8. Physical and social functional abilities seem to be maintained by a multifaceted randomized controlled nutritional intervention among old (>65 years) Danish nursing home residents.

    Science.gov (United States)

    Beck, Anne Marie; Damkjaer, Karin; Sørbye, Liv W

    2010-01-01

    The purpose was to test the hypothesis that a multifaceted 11 weeks randomized controlled intervention would have a significant influence of functional abilities in old nursing home residents. Participants were 121 old (>65 years) residents in seven Danish nursing homes. The intervention consisted of nutrition (chocolate, homemade oral supplements), group exercise (moderate intensity) and oral care. Measurements taken were weight, body mass index (BMI), energy and protein intake, and functional abilities (activities of daily living=ADL, cognitive performance, and social engagement). The results showed that the nutrition and exercise were well accepted. After 11 weeks the change in % weight (1.3 vs. -0.6%, p=0.005), % BMI (0.4 vs. -0.2%, p=0.003), energy intake (0.7 vs. -0.3 MJ/day, p=0.084) and protein intake (5 vs. -2g/day, p=0.012) was higher in the intervention group than in the control group. Also, after 11 weeks, social and physical function had decreased in the control group but was unchanged in the intervention group. The difference between groups was significant in relation to social engagement (p=0.009). After the end of the intervention both groups had lost weight and physical function. Cognitive performance did not change, at any time. In conclusion, it seems possible to maintain social (and physical) functional abilities in old nursing home residents by means of a multifaceted intervention.

  9. Validity of Self-Report Measures of Defense Mechanisms

    Science.gov (United States)

    Mehlman; Slane

    1994-06-01

    The Life Style Index (LSI), the Defense Style Questionnaire (DSQ), the Defense Mechanisms Inventory (DMI), and the FIRO Coping Operations Preferences Enquiry (FIRO) were administered to 187 undergraduates in order to determine convergent and discriminant validity of self-report measures of defense mechanisms. A correlational analysis of the four scales resulted in low correlations among subscales measuring similar defense mechanisms. A factor analysis produced factors based on particular scales rather than identical or similar constructs. Results suggest that self-report measures may not be an effective method for assessing various ego defense strategies.

  10. Insect response to plant defensive protease inhibitors.

    Science.gov (United States)

    Zhu-Salzman, Keyan; Zeng, Rensen

    2015-01-07

    Plant protease inhibitors (PIs) are natural plant defense proteins that inhibit proteases of invading insect herbivores. However, their anti-insect efficacy is determined not only by their potency toward a vulnerable insect system but also by the response of the insect to such a challenge. Through the long history of coevolution with their host plants, insects have developed sophisticated mechanisms to circumvent antinutritional effects of dietary challenges. Their response takes the form of changes in gene expression and the protein repertoire in cells lining the alimentary tract, the first line of defense. Research in insect digestive proteases has revealed the crucial roles they play in insect adaptation to plant PIs and has brought about a new appreciation of how phytophagous insects employ this group of molecules in both protein digestion and counterdefense. This review provides researchers in related fields an up-to-date summary of recent advances.

  11. National Defense Budget Estimates for FY 2012

    Science.gov (United States)

    2011-03-01

    Military Construction, Navy Reserve 21,708 26,299 26,299 26,299 Military Construction, Air Force Reserve 25,986 33,620 33,620 33,620 Chemical Demil ...Air Force Reserve 7,634 Chemical Demil Construction, Defense 75,312 13,071,701 Appropriation 13,071,701 Budget Authority 13,071,701 TOA...7.00 3.00 Defense Prod Act 59.00 25.00 16.00 Chemical Demil 53.00 30.00 15.00 2.00 RDT&E Army 34.28 48.72 11.33 3.17 1.70 0.80 Navy 36.87 50.51 9.82

  12. Is European Defense a Bridge too Far?

    Science.gov (United States)

    2006-03-08

    complex security protocol was developed to share classified information. 6 After 9/11 The world changed dramatically the morning of 11 September 2001...European defense. This question, basic to defining a strategy of European security, is still pending and underlies all other debates and decisions...Internet; accessed 15 December 2005. 18 Grupo de Estudios Estrategicos GEES, “The Spanish Identity in the European Defence Industry,” Analisis 12, 8

  13. Defense and detection strategies against Internet worms

    CERN Document Server

    Nazario, José

    2004-01-01

    This is the first book focused exclusively on Internet worms, offering you solid worm detection and mitigation strategies for your work in the field. This ground-breaking volume enables you to put rising worm trends into perspective with practical information in detection and defense techniques utilizing data from live networks, real IP addresses, and commercial tools. The book helps you understand the classifications and groupings of worms, and offers a deeper understanding of how they threaten network and system security.

  14. Information on Japanese Defensive Installations and Tactics

    Science.gov (United States)

    1945-01-01

    caves* These’ caves were extremely well camouflaged . and, in a few isolated places,, were protected by sliding steel doors against which flame... camouflage were present. In addition, artil- lery "Data- Sheets" were discovered which: indicated that the guns were to bo employed as a- battery . This...34 Octopus -pot11 defensive positions. . Blue troops usually refer to them as "pimples" because of the relatively small hills on which they have been

  15. Research on Nonlinear Dynamics with Defense Applications

    Science.gov (United States)

    2006-04-01

    numerical verifications, we have experimentally realized the scheme by using a Duffing -type of nonlinear electronic oscillator (originally developed by C...circuits In defense applications it may be desirable to induce chaos in nonlinear oscillators operating in a stable regime. Examples of such oscillators ...evolutions of the target Duffing circuit and deliver resonant perturbations to generate robust chaotic attractors. A brief account of the work has been

  16. Defense Trade Data: Sources and Recommendations

    Science.gov (United States)

    2010-11-01

    detailed trade information on such products may be difficult. Recent U.S. concerns have ranged from dependency on rare earths and first level products...BHUTAN BR INDIAN OCEAN TERR EGYPT INDIA IRAN IRAQ ISRAEL JORDAN KOWAIT LEBANON LIBYA MALDIVES MOROCCO NEPAL OMAN PAKISTAN QATAR SAODI...specifically designed or developed for military application and any computer specifically modified for use with any defense article in any category of

  17. The cuticle and plant defense to pathogens

    Directory of Open Access Journals (Sweden)

    Jean-Pierre eMetraux

    2014-06-01

    Full Text Available The cuticle provides a physical barrier against water loss and protects against irradiation, xenobiotics and pathogens. Components of the cuticle are perceived by invading fungi and activate developmental processes during pathogenesis. In addition, cuticle alterations of various types induce a syndrome of reactions that often results in resistance to necrotrophs. This article reviews the current knowledge on the role of the cuticle in relation to the perception of pathogens and activation of defenses.

  18. Russian Ballistic Missile Defense: Rhetoric and Reality

    Science.gov (United States)

    2015-06-01

    2012/06/08/russia_installs_new_radars_as_a_ deterrent_15834.html. 130. “Direct Line with Vladimir Putin ,” President of Russia , April 17, 2014...and increases the danger of war. In his 2012 pre-election treatise on defense policy and national security, Rus- sian President Vladimir Putin ...Kontsern PVO Almaz-Antey) was established by President Vladimir Putin in 2002 uniting no fewer than 46 enterprises, including factories, research and

  19. Implications of Germany's declining defense spending

    OpenAIRE

    Merrath, Jurgen

    2000-01-01

    With its reunification on 3 October 1990, Germany regained its full sovereignty and stands now in a position of greater global responsibility. Faced with dramatically increased demands on and expectations for Germany's armed forces, it must answer the question of how much it is willing to invest for safety and stability in Europe and for protection of peace in the world. In determining the level of commitment behind Germany's foreign and security policy, defense spending is an important indic...

  20. The Defense of Henderson Field, Guadalcanal

    Science.gov (United States)

    2011-03-31

    of US airpower an4 know disruption ofsuch power is critical to achieving their goals. Most US airpower operates from airbases, which can be...Vandegrift remained in his defensive positions because he did not know the size, strength, location, or intentions of the Japanese main body.67 Ichiki...Parachute/Raider Battalion. 75 Edson deployed his 830 men South of Henderson Field in a series of mut ~ally supporting strongnolds. He was flanked to

  1. A Content Analysis of Defense Budget Rhetoric

    Science.gov (United States)

    2011-06-01

    President’s budget. 14. SUBJECT TERMS Defense Budget, Content Analysis, Political Discourse, Budget Rhetoric, Political Communication , Senate Armed...represent the most recent paradigm shift in political communication research (Scheufele & Tewksbury, 2007, p. 10). These three models combine to construct...this study was to fill the gap on political communication by examining whether Congress was responsive to framing by the President’s budget. To

  2. Affordability Constraints in Major Defense Acquisitions

    Science.gov (United States)

    2016-11-01

    price , this is actually an inverse supply curve. In competitive markets, the inverse supply curve is the firm’s marginal cost curve. When firms have a...support features and functions. The vertical axis represents the unit sale price , inclusive of all life-cycle or total ownership costs as appropriate...Three Defense Programs 3 We can easily extend the example to incorporate cost - plus payment schemes

  3. Defense Horizons. Number 78, March 2015

    Science.gov (United States)

    2015-03-01

    databases , National Defense University researchers have identified 124 examples of effective P4s across a wide spectrum of industries and...environment. notes 1 A review of multiple databases , case studies, and concept papers has identified over 4,000 examples of public-public and public...Partnering,” SONRI, Inc., 2010. 8 Farming First, “Innovation and Incentives for Farmers Needed to Protect World’s Biodiversity ,” press release, May 21

  4. United States Civil Military Relations: Defense Reform

    Science.gov (United States)

    2016-03-01

    358–421. 154 Lederman, Reorganizing the Joint Chiefs of Staff, 74. 155 Thomas L. McNaugher and Roger L. Sperry , “Improving Military Coordination...edited by Thomas C. Bruneau and Florina Cristiana Matei, 26–38. New York: Routledge Taylor and Francis, 2015. McNaugher, Thomas L. and Roger L... Sperry . “Improving Military Coordination: The Goldwater-Nichols Reorganization of the Department of Defense.” In Who Makes Public Policy: The

  5. Department of Defense Energy Management Plan, 1980

    Science.gov (United States)

    1980-07-01

    Energy Usage in Existing Buildings . .......... .111-29 111-11 Timetable for Developing Utility Efficiency Standards ................. .......... 111-30...in the Defense Energy Emergency Planning System (DEEMS) document (Appendix A). The purpose of the DEEMS is to assure the availabilty of fuels to the...unleaded gasoline usage , y 1985. It is anticipated that sufficient supplies of ’alcohol and non-petroleum derived fuel will be available. DoD’s

  6. Defense Primer: A Guide for New Members

    Science.gov (United States)

    2017-03-03

    3 Research, Development , Test, and Evaluation .......................................................................... 3 Defense...Navy,” “to make Rules for the Government and Regulation of the land and naval Forces,” and “to provide for organizing , arming, and disciplining the...Militia, and for governing such Part of them as may be employed in the Service of the United States.... ” CRS has developed a series of short

  7. 32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral...

  8. Defense mechanisms in schizotypal, borderline, antisocial, and narcissistic personality disorders.

    Science.gov (United States)

    Perry, J Christopher; Presniak, Michelle D; Olson, Trevor R

    2013-01-01

    Numerous authors have theorized that defense mechanisms play a role in personality disorders. We reviewed theoretical writings and empirical studies about defenses in schizotypal, borderline, antisocial, and narcissistic personality disorders, developing hypotheses about these differential relationships. We then examined these hypotheses using dynamic interview data rated for defenses in a study of participants (n = 107) diagnosed with these four personality disorder types. Overall, the prevalence of immature defenses was substantial, and all four disorders fit within the broad borderline personality organization construct. Defenses predicted the most variance in borderline and the least variance in schizotypal personality disorder, suggesting that dynamic factors played the largest role in borderline and the least in schizotypal personality. Central to borderline personality were strong associations with major image-distorting defenses, primarily splitting of self and other's images, and the hysterical level defenses, dissociation and repression. Narcissistic and antisocial personality disorders shared minor image-distorting defenses, such as omnipotence or devaluation, while narcissistic also used splitting of self-images and antisocial used disavowal defenses like denial. Overall, differential relationships between specific defenses and personality disorder types were largely consistent with the literature, and consistent with the importance that the treatment literature ascribes to working with defenses.

  9. Landscape Variation in Plant Defense Syndromes across a Tropical Rainforest

    Science.gov (United States)

    McManus, K. M.; Asner, G. P.; Martin, R.; Field, C. B.

    2014-12-01

    Plant defenses against herbivores shape tropical rainforest biodiversity, yet community- and landscape-scale patterns of plant defense and the phylogenetic and environmental factors that may shape them are poorly known. We measured foliar defense, growth, and longevity traits for 345 canopy trees across 84 species in a tropical rainforest and examined whether patterns of trait co-variation indicated the existence of plant defense syndromes. Using a DNA-barcode phylogeny and remote sensing and land-use data, we investigated how phylogeny and topo-edaphic properties influenced the distribution of syndromes. We found evidence for three distinct defense syndromes, characterized by rapid growth, growth compensated by defense, or limited palatability/low nutrition. Phylogenetic signal was generally lower for defense traits than traits related to growth or longevity. Individual defense syndromes were organized at different taxonomic levels and responded to different spatial-environmental gradients. The results suggest that a diverse set of tropical canopy trees converge on a limited number of strategies to secure resources and mitigate fitness losses due to herbivory, with patterns of distribution mediated by evolutionary histories and local habitat associations. Plant defense syndromes are multidimensional plant strategies, and thus are a useful means of discerning ecologically-relevant variation in highly diverse tropical rainforest communities. Scaling this approach to the landscape level, if plant defense syndromes can be distinguished in remotely-sensed data, they may yield new insights into the role of plant defense in structuring diverse tropical rainforest communities.

  10. Inducible defenses in prey intensify predator cannibalism.

    Science.gov (United States)

    Kishida, Osamu; Trussell, Geoffrey C; Nishimura, Kinya; Ohgushi, Takayuki

    2009-11-01

    Trophic cascades are often a potent force in ecological communities, but abiotic and biotic heterogeneity can diffuse their influence. For example, inducible defenses in many species create variation in prey edibility, and size-structured interactions, such as cannibalism, can shift predator diets away from heterospecific prey. Although both factors diffuse cascade strength by adding heterogeneity to trophic interactions, the consequences of their interactioh remain poorly understood. We show that inducible defenses in tadpole prey greatly intensify cannibalism in predatory larval salamanders. The likelihood of cannibalism was also strongly influenced by asymmetries in salamander size that appear to be most important in the presence of defended prey. Hence, variation in prey edibility and the size structure of the predator may synergistically affect predator-prey population dynamics by reducing prey mortality and increasing predator mortality via cannibalism. We also suggest that the indirect effects of prey defenses may shape the evolution of predator traits that determine diet breadth and how trophic dynamics unfold in natural systems.

  11. Tsunami Defense Efforts at Samcheok Port, Korea

    Science.gov (United States)

    Cho, Y. S.

    2016-02-01

    Tsunamis mainly triggered by impulsive undersea motions are long waves and can propagate a long distance. Thus, they can cause huge casualties not only neighboring countries but also distant countries. Recently, several devastating tsunamis have been occurred around the Pacific Ocean rim. Among them, the Great East Japan tsunami occurred on March 11, 2011 is probably recorded as one of the most destructive tsunamis during last several decades. The Tsunami killed more than 20,000 people (including missing people) and deprived of property damage of approximately 300 billion USD. The eastern coast of the Korean Peninsula has been attacked historically by unexpected tsunami events. These tsunamis were generated by undersea earthquakes occurred off the west coast of Japan. For example, the Central East Sea Tsunami occurred on May 26, 1983 killed 3 people and caused serious property damage at Samcheok Port located at the eastern coast of Korea. Thus, a defense plan against unexpected tsunami strikes is an essential task for the port authority to protect lives of human beings and port facilities. In this study, a master plan of tsunami defense is introduced at Samcheok Port. A tsunami hazard map is also made by employing both propagation and inundation models. Detailed defense efforts are described including the procedure of development of a tsunami hazard map. Keywords: tsunami, hazard map, run-up height, emergency action plan

  12. Defensive measures against hostile takeovers in Slovenia

    Directory of Open Access Journals (Sweden)

    Andrej Bertoncel

    2005-12-01

    Full Text Available This article summarizes the corporate takeover regime and defensive measures against hostile takeover bids in Slovenia. Although takeover legislation does not differentiate between hostile and friendly takeover, it prescribes the limitation of powers for the management of the target company, with the intention of preventing the use of defensive measures against the hostile takeover. In light of an expected rise in hostile takeover bids in Slovenia, the Corporate Act and the Takeover Act are analysed and accordingly the array of possible preventive measures as well as ad-hoc measures against hostile bids identified and evaluated for their anti-takeover effectiveness. A hostile takeover in Slovenia usually involves a hostile public tender offer at a substantial premium over the prevailing market price for a substantial percentage of the target company’s stock. Managers of target companies use in takeover battles a variety of defensive tactics, which could be controversial because they pose a conflict of interest for management. Duty of neutrality of the management of the target company during takeover process is therefore discussed in connection with the limitation of use of applicable ad hoc defence mechanisms in that period.

  13. Antiviral Defenses in Plants through Genome Editing

    Science.gov (United States)

    Romay, Gustavo; Bragard, Claude

    2017-01-01

    Plant–virus interactions based-studies have contributed to increase our understanding on plant resistance mechanisms, providing new tools for crop improvement. In the last two decades, RNA interference, a post-transcriptional gene silencing approach, has been used to induce antiviral defenses in plants with the help of genetic engineering technologies. More recently, the new genome editing systems (GES) are revolutionizing the scope of tools available to confer virus resistance in plants. The most explored GES are zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats/Cas9 endonuclease. GES are engineered to target and introduce mutations, which can be deleterious, via double-strand breaks at specific DNA sequences by the error-prone non-homologous recombination end-joining pathway. Although GES have been engineered to target DNA, recent discoveries of GES targeting ssRNA molecules, including virus genomes, pave the way for further studies programming plant defense against RNA viruses. Most of plant virus species have an RNA genome and at least 784 species have positive ssRNA. Here, we provide a summary of the latest progress in plant antiviral defenses mediated by GES. In addition, we also discuss briefly the GES perspectives in light of the rebooted debate on genetic modified organisms (GMOs) and the current regulatory frame for agricultural products involving the use of such engineering technologies. PMID:28167937

  14. Extracellular DNA: the tip of root defenses?

    Science.gov (United States)

    Hawes, Martha C; Curlango-Rivera, Gilberto; Wen, Fushi; White, Gerard J; Vanetten, Hans D; Xiong, Zhongguo

    2011-06-01

    This review discusses how extracellular DNA (exDNA) might function in plant defense, and at what level(s) of innate immunity this process might operate. A new role for extracellular factors in mammalian defense has been described in a series of studies. These studies reveal that cells including neutrophils, eosinophils, and mast cells produce 'extracellular traps' (ETs) consisting of histone-linked exDNA. When pathogens are attracted to such ETs, they are trapped and killed. When the exDNA component of ETs is degraded, trapping is impaired and resistance against invasion is reduced. Conversely, mutation of microbial genes encoding exDNases that degrade exDNA results in loss of virulence. This discovery that exDNases are virulence factors opens new avenues for disease control. In plants, exDNA is required for defense of the root tip. Innate immunity-related proteins are among a group of >100 proteins secreted from the root cap and root border cell populations. Direct tests revealed that exDNA also is rapidly synthesized and exported from the root tip. When this exDNA is degraded by the endonuclease DNase 1, root tip resistance to fungal infection is lost; when the polymeric structure is degraded more slowly, by the exonuclease BAL31, loss of resistance to fungal infection is delayed accordingly. The results suggest that root border cells may function in a manner analogous to that which occurs in mammalian cells.

  15. Electroconvulsive Therapy Malpractice: Verdict for the Defense.

    Science.gov (United States)

    Goodman, Theodore; McCall, W Vaughn

    2015-09-01

    Malpractice cases involving electroconvulsive therapy (ECT) are rare. Even rarer are those malpractice cases alleging ECT-related brain damage. The few cases of ECT malpractice lawsuits are not described in the medical literature in detail. We provide a detailed account of a case of a patient and subsequent alleged ECT-related malpractice. The details of the case were collated using the handwritten notes of one of the authors who was present at the trial and the pretrial documents of discovery that were entered into evidence. The plaintiff alleged complete autobiographical amnesia after ECT, supposedly as a result of ECT-related brain damage. The defense was aided by the presence of extensive neurological examination and brain imaging both before and after ECT. The defense team also offered to the jury the concept of "dissociative amnesia" as an alternative explanation for the plaintiff's memory complaints. The case went to trial and was successfully defended. Electroconvulsive therapy malpractice cases alleging brain damage can be successfully defended, and the successful defense is aided by adequate documentation before, during, and after ECT. Malpractice cases, especially if they are baseless, can occur unpredictably, but they can be defended if the medical documentation is thorough.

  16. DEFENSE RESOURCES MANAGEMENT USING GAME THEORY

    Directory of Open Access Journals (Sweden)

    Marian NEDELCU

    2014-04-01

    Full Text Available Game theory provides a number of analytical tools designed to assist in developing a more comprehensive understanding of phenomena emerging when decision makers interact. A game describes the strategic interactions between players who act guided by their interests and with the consciousness that their actions affect each other. The basic entity in all game theory models is the player. A player may be understood as an individual, group of individuals or any kind of organization, even countries or alliances facing decisions-making challenges and opportunities. In this respect, the concept providing the dimensions and variables informing on the planning “game” elements required for an optimal defense resource allocation is that of ‘capabilities’. The model developed in this paper is focused on allocations of the available defense resources over the assumed capabilities in order to achieve the best response to national security. I consider as a game the competition between strategic decision-makers involved in defense resource management and the threats to the national security.

  17. PTSD as a criminal defense: a review of case law.

    Science.gov (United States)

    Berger, Omri; McNiel, Dale E; Binder, Renée L

    2012-01-01

    Posttraumatic stress disorder (PTSD) has been offered as a basis for criminal defenses, including insanity, unconsciousness, self-defense, diminished capacity, and sentencing mitigation. Examination of case law (e.g., appellate decisions) involving PTSD reveals that when offered as a criminal defense, PTSD has received mixed treatment in the judicial system. Courts have often recognized testimony about PTSD as scientifically reliable. In addition, PTSD has been recognized by appellate courts in U.S. jurisdictions as a valid basis for insanity, unconsciousness, and self-defense. However, the courts have not always found the presentation of PTSD testimony to be relevant, admissible, or compelling in such cases, particularly when expert testimony failed to show how PTSD met the standard for the given defense. In cases that did not meet the standard for one of the complete defenses, PTSD has been presented as a partial defense or mitigating circumstance, again with mixed success.

  18. “Horses for Courses”; Comment on “Translating Evidence Into Healthcare Policy and Practice: Single Versus Multi-Faceted Implementation Strategies – Is There a Simple Answer to a Complex Question?”

    Directory of Open Access Journals (Sweden)

    Joyce E. Wilkinson

    2015-10-01

    Full Text Available This commentary considers the vexed question of whether or not we should be spending time and resources on using multifaceted interventions to undertake implementation of evidence in healthcare. A review of systematic reviews has suggested that simple interventions may be just as effective as those taking a multifaceted approach. Taking cognisance of the Promoting Action on Research Implementation in Health Services (PARIHS framework this commentary takes account of the evidence, context and facilitation factors in undertaking implementation. It concludes that a ‘horses for courses’ approach is necessary meaning that the specific implementation approach should be selected to fit the implementation task in hand whether it be a single or multifaceted approach and reviewed on an individual basis.

  19. The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities.

    Science.gov (United States)

    Pant, Saumya; Hilton, Holly; Burczynski, Michael E

    2012-06-01

    Exosomes are bioactive vesicles derived from the cell's endosomal membrane system and secreted into surrounding body fluids. Exosomes contain cell and cell-state specific cargos of protein, mRNA and miRNA. Exosome formation, cargo content, and delivery to surrounding cells is of immense biological interest considering the role that exosomes are believed to play in various pathological conditions. They aid antigen presentation by immune cells and can exhibit either anti-inflammatory or pro-inflammatory properties depending on the parent antigen-presenting cell's conditioning. Viruses can hijack a host cell's exosomal machinery to evade host defense systems aiding in the trans-infection of viruses. Tumor derived exosomes may help establish an oncogenic niche systemically via delivery of protein, mRNA, and miRNA that can aid angiogenesis, cell proliferation, and cell survival. Exosomes have also been implicated in the spread of neurodegenerative diseases. Studies have shown that exosomes are selectively taken up by cells distal from their release. They can reprogram the recipient cells due to their active molecular cargo. Cell-lineage and state-specific exosomes imply that they may therefore harbor body fluid-based biomarkers of unparalleled accuracy, particularly for tissues that are difficult or impossible to access. Exosome-specific membrane proteins provide markers enabling exosome identity and selection, while cell type and cell condition-specific protein, mRNA and miRNA cargo provide a rich potential source of biomarkers. This review serves to provide an overview of the current state of the science in the burgeoning field of exosome biology.

  20. Health Alliance for prudent antibiotic prescribing in patients with respiratory tract infections (HAPPY AUDIT -impact of a non-randomised multifaceted intervention programme

    Directory of Open Access Journals (Sweden)

    Reutskiy Anatoliy

    2011-06-01

    Full Text Available Abstract Background Excessive use of antibiotics is worldwide the most important reason for development of antimicrobial resistance. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial resistance is an important issue with a potential serious impact on all countries. Initiatives have been taken to improve the quality of antibiotic prescribing in primary care, but only few studies have been designed to determine the effectiveness of multifaceted strategies across countries with different practice setting. The aim of this study was to evaluate the impact of a multifaceted intervention targeting general practitioners (GPs and patients in six countries with different health organization and different prevalence of antibiotic resistance. Methods GPs from two Nordic countries, two Baltic Countries and two Hispano-American countries registered patients with respiratory tract infections (RTIs in 2008 and 2009. After first registration they received individual prescriber feedback and they were offered an intervention programme that included training courses, clinical guidelines, posters for waiting rooms, patient brochures and access to point of care tests (Strep A and C-Reactive Protein. Antibiotic prescribing rates were compared before and after the intervention. Results A total of 440 GPs registered 47011 consultations; 24436 before the intervention (2008 and 22575 after the intervention (2009. After the intervention, the GPs significantly reduced the percentage of consultations resulting in an antibiotic prescription. In patients with lower RTI the GPs in Lithuania reduced the prescribing rate by 42%, in Russia by 25%, in Spain by 25%, and in Argentina by 9%. In patients with upper RTIs, the corresponding reductions in the antibiotic prescribing rates were in Lithania 20%, in Russia 15%, in Spain 9%, and in Argentina 5

  1. Health Alliance for prudent antibiotic prescribing in patients with respiratory tract infections (HAPPY AUDIT) -impact of a non-randomised multifaceted intervention programme.

    Science.gov (United States)

    Bjerrum, Lars; Munck, Anders; Gahrn-Hansen, Bente; Hansen, Malene Plejdrup; Jarbol, Dorte Ejg; Cordoba, Gloria; Llor, Carl; Cots, Josep Maria; Hernández, Silvia; López-Valcárcel, Beatriz González; Pérez, Antonia; Caballero, Lidia; von der Heyde, Walter; Radzeviciene, Ruta; Jurgutis, Arnoldas; Reutskiy, Anatoliy; Egorova, Elena; Strandberg, Eva Lena; Ovhed, Ingvar; Mölstad, Sigvard; Stichele, Robert Vander; Benko, Ria; Vlahovic-Palcevski, Vera; Lionis, Christos; Rønning, Marit

    2011-06-20

    Excessive use of antibiotics is worldwide the most important reason for development of antimicrobial resistance. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial resistance is an important issue with a potential serious impact on all countries. Initiatives have been taken to improve the quality of antibiotic prescribing in primary care, but only few studies have been designed to determine the effectiveness of multifaceted strategies across countries with different practice setting. The aim of this study was to evaluate the impact of a multifaceted intervention targeting general practitioners (GPs) and patients in six countries with different health organization and different prevalence of antibiotic resistance. GPs from two Nordic countries, two Baltic Countries and two Hispano-American countries registered patients with respiratory tract infections (RTIs) in 2008 and 2009. After first registration they received individual prescriber feedback and they were offered an intervention programme that included training courses, clinical guidelines, posters for waiting rooms, patient brochures and access to point of care tests (Strep A and C-Reactive Protein). Antibiotic prescribing rates were compared before and after the intervention. A total of 440 GPs registered 47011 consultations; 24436 before the intervention (2008) and 22575 after the intervention (2009). After the intervention, the GPs significantly reduced the percentage of consultations resulting in an antibiotic prescription. In patients with lower RTI the GPs in Lithuania reduced the prescribing rate by 42%, in Russia by 25%, in Spain by 25%, and in Argentina by 9%. In patients with upper RTIs, the corresponding reductions in the antibiotic prescribing rates were in Lithania 20%, in Russia 15%, in Spain 9%, and in Argentina 5%. A multifaceted intervention programme targeting GPs

  2. Efficacy of a multifaceted podiatry intervention to improve balance and prevent falls in older people: study protocol for a randomised trial

    Directory of Open Access Journals (Sweden)

    Menz Hylton B

    2008-11-01

    Full Text Available Abstract Background Falls in older people are a major public health problem, with at least one in three people aged over 65 years falling each year. There is increasing evidence that foot problems and inappropriate footwear increase the risk of falls, however no studies have been undertaken to determine whether modifying these risk factors decreases the risk of falling. This article describes the design of a randomised trial to evaluate the efficacy of a multifaceted podiatry intervention to reduce foot pain, improve balance, and reduce falls in older people. Methods Three hundred community-dwelling men and women aged 65 years and over with current foot pain and an increased risk of falling will be randomly allocated to a control or intervention group. The "usual cae" control group will receive routine podiatry (i.e. nail care and callus debridement. The intervention group will receive usual care plus a multifaceted podiatry intervention consisting of: (i prefabricated insoles customised to accommodate plantar lesions; (ii footwear advice and assistance with the purchase of new footwear if current footwear is inappropriate; (iii a home-based exercise program to strengthen foot and ankle muscles; and (iv a falls prevention education booklet. Primary outcome measures will be the number of fallers, number of multiple fallers and the falls rate recorded by a falls diary over a 12 month period. Secondary outcome measures assessed six months after baseline will include the Medical Outcomes Study Short Form 12 (SF-12, the Manchester Foot Pain and Disability Index, the Falls Efficacy Scale International, and a series of balance and functional tests. Data will be analysed using the intention to treat principle. Discussion This study is the first randomised trial to evaluate the efficacy of podiatry in improving balance and preventing falls. The trial has been pragmatically designed to ensure that the findings can be generalised to clinical practice. If

  3. Cost-effectiveness of a multifaceted implementation strategy for the Dutch multidisciplinary guideline for nonspecific low back pain: design of a stepped-wedge cluster randomised controlled trial.

    Science.gov (United States)

    Suman, Arnela; Schaafsma, Frederieke G; Elders, Petra J M; van Tulder, Maurits W; Anema, Johannes R

    2015-05-31

    Low back pain (LBP) is one of the most prevalent and expensive health care problems in industrialised countries. LBP leads to high health care utility and productivity losses; leaving the individual, the employer, and society with substantial costs. To improve the care for LBP patients and reduce the high societal and financial burden of LBP, in 2010 the 'Multidisciplinary care guideline for nonspecific low back pain' was developed in the Netherlands. The current paper describes the design of a study aiming to evaluate the (cost-) effectiveness of a multifaceted strategy to implement this guideline. In a cluster-randomised controlled trial, the (cost-) effectiveness of a multifaceted implementation strategy will be compared to passive guideline dissemination. Using a stepped-wedge approach, participating general practitioners, physiotherapists, and occupational physicians are allocated into clusters and will attend a multidisciplinary continuing medical education training session. The timing these clusters receive the training is the unit of randomisation. LBP patients visiting the participating health care providers are invited to participate in the trial and will receive access to a multimedia intervention aimed at improving beliefs, cognitions, and self-management. The primary outcome measure of this study is patient back beliefs. Secondary outcome measures on patient level include pain, functional status, quality of life, health care utility, and productivity losses. Outcome measures on professional level include knowledge and attitude towards the guideline, and guideline adherence. A process evaluation for the implementation strategy will be performed among the health care providers and the patients. Furthermore, a qualitative subgroup analysis among patients with various ethnic backgrounds will be performed. This study will give insight into the (cost-) effectiveness of a multifaceted implementation strategy for the Dutch multidisciplinary guideline for non

  4. Inducible defenses against herbivory and fouling in seaweeds

    Science.gov (United States)

    Pereira, Renato Crespo; Costa, Erica da Silva; Sudatti, Daniela Bueno; da Gama, Bernardo Antonio Perez

    2017-04-01

    Secondary metabolites play an important ecological role as a defense mechanism in seaweeds. Chemical defenses are well known to change in response to herbivory, but other driving factors, either biotic or abiotic, are often neglected. Epibiosis may not only reduce seaweed fitness, but also increase attractiveness to consumers, and thus defense production should also be triggered by epibionts. In this study, three Southwestern Atlantic seaweeds, Gracilaria cearensis, Pterocladiella capillacea (Rhodophyceae) and Codium decorticatum (Chlorophyceae) were investigated in laboratory bioassays designed to test whether the action of herbivory or simulated epibiosis influences chemical defenses. Crossed induction experiments were also performed in order to assess whether herbivore induction influences antifouling chemical defense, as well as whether epibiont induction would affect defense against herbivores. The effect of laboratory conditions on seaweeds in the absence of field stimuli was also investigated by comparing consumption of artificial food with extracts from acclimatized and non-acclimatized seaweeds (i.e., natural defense levels). Only the green seaweed C. decorticatum exhibited inducible antifouling defenses triggered by simulated epibiosis, but not by herbivores. In the other seaweeds there was no induction either by herbivory or simulated epibiosis. Acclimatization did not affect C. decorticatum defenses. However, non-acclimatized G. cearensis artificial foods were preferred over acclimatized ones, while extracts from acclimatized P. capillacea increased herbivore consumption, highlighting the need to acclimatize seaweeds before the main induction experiments. This is the first report of inducible defenses due to simulated fouling in seaweeds.

  5. The Youth Empowered for Success Program: A Multi-faceted Approach to Youth Leadership Development and School Culture Change in Southern Arizona

    Directory of Open Access Journals (Sweden)

    Pam Parrish

    2008-09-01

    Full Text Available Arizona’s first Teen Institute (TI program, Youth Empowered for Success, began in July 2004. It is the first TI-based project to focus on nurturing resilience via Health Realization (Pransky, 2007. The YES program’s design to “create conditions for success” in high schools is discussed. YES utilizes a strengths-based, multi-faceted approach of (1 teaching participants how to access their innate resilience and common sense (Health Realization, (2 training them in community development for school culture change and (3 helping them develop meaningful partnerships with adults. YES also expands upon the TI model by providing staff support for community development throughout the academic year. It is hypothesized that these efforts ultimately will increase overall well-being and reduce the incidence of alcohol, tobacco and other drug use (ATOD as well as depression and suicide among youth.

  6. Associations of Sexual Victimization, Depression, and Sexual Assertiveness with Unprotected Sex: A Test of the Multifaceted Model of HIV Risk Across Gender

    Science.gov (United States)

    Morokoff, Patricia J.; Redding, Colleen A.; Harlow, Lisa L.; Cho, Sookhyun; Rossi, Joseph S.; Meier, Kathryn S.; Mayer, Kenneth H.; Koblin, Beryl; Brown-Peterside, Pamela

    2014-01-01

    This study examined whether the Multifaceted Model of HIV Risk (MMOHR) would predict unprotected sex based on predictors including gender, childhood sexual abuse (CSA), sexual victimization (SV), depression, and sexual assertiveness for condom use. A community-based sample of 473 heterosexually active men and women, aged 18–46 years completed survey measures of model variables. Gender predicted several variables significantly. A separate model for women demonstrated excellent fit, while the model for men demonstrated reasonable fit. Multiple sample model testing supported the use of MMOHR in both men and women, while simultaneously highlighting areas of gender difference. Prevention interventions should focus on sexual assertiveness, especially for CSA and SV survivors, as well as targeting depression, especially among men. PMID:25018617

  7. Economic Evaluation of a Multifaceted Implementation Strategy for the Prevention of Hand Eczema Among Healthcare Workers in Comparison with a Control Group: The Hands4U Study.

    Science.gov (United States)

    van der Meer, Esther W C; van Dongen, Johanna M; Boot, Cécile R L; van der Gulden, Joost W J; Bosmans, Judith E; Anema, Johannes R

    2016-05-01

    The aim of this study was to evaluate the cost-effectiveness of a multifaceted implementation strategy for the prevention of hand eczema in comparison with a control group among healthcare workers. A total of 48 departments (n=1,649) were randomly allocated to the implementation strategy or the control group. Data on hand eczema and costs were collected at baseline and every 3 months. Cost-effectiveness analyses were performed using linear multilevel analyses. The probability of the implementation strategy being cost-effective gradually increased with an increasing willingness-to-pay, to 0.84 at a ceiling ratio of €590,000 per person with hand eczema prevented (societal perspective). The implementation strategy appeared to be not cost-effective in comparison with the control group (societal perspective), nor was it cost-beneficial to the employer. However, this study had some methodological problems which should be taken into account when interpreting the results.

  8. Report of the Defense Science Board Subcommittee on Department of Defense Research Policy. Part 1. Policy on Support of Basic Research

    Science.gov (United States)

    1963-12-31

    f. .. AD-A955 482 Report of the Defen e Science Board Subcomtnittee on Depart•eat of Defense RESEARCH POLICY OTIC SELECTED NOV 2 91J88 0(/H...ACCESSION NO NA 11 TITLE (inc/ud* Stcunty Oassificat/on) Report of the Defense Science Board Subcomittee on Department of Defense Research Policy , Part...Defense Research Policy Office of the Director of Defense Research and Engineering Washington, D. C. 31 December 1963 OFFICE OF THE DIRECTOR OF DEFENSE

  9. Toward a defense-dominated world

    Energy Technology Data Exchange (ETDEWEB)

    Wood, L.

    1993-08-01

    Maintaining the large-scale peace in a defense-dominated world necessarily will require not only passive but also active defenses against large-scale aggression that are technically feasible, practical and easy to employ -- and robust against perversion into support of aggression. Such peace maintenance tool-sets will feature means for effectively rebuking aggression as well as providing timely and very widely available seaming of aggression underway anywhere. This report discusses the technology base which currently exists to provide world-wide, high-quality imagery at moderate (5--10 meter) spatial resolution or imagery of 1% of the Earth`s land surface at high ({le} 1 meter) resolution no less frequently than daily, at a total cost of the order of $1 B, with operational capability in the later `90s. Such systems could provide timely warning of aggressive actions anywhere. Similarly, space-based means of defeating aggression conducted with even quite short-range ballistic missiles anywhere in the world could be brought into existence by the end of the `90s for a total cost of about $10 B, and small high-altitude, long flight-duration robotic aircraft carrying high-performance sensors and interceptor missilery could provide both seaming and active defenses against attacks conducted with very short range ballistic missiles, as well as attacks launched with air-breathing threats such as bombers and cruise missiles, for a cost per defended area of the order of $10/km{sup 2}. It appears that all of the associated sensors can find apt dual-use as high-performance systems for monitoring physical aspects of the human environment.

  10. Narcissism and defense mechanisms in women

    Directory of Open Access Journals (Sweden)

    Sabina Bele

    2014-06-01

    Full Text Available The purpose of this research was to examine how the level of covert and overt narcissism is connected to the frequency of the use of defense mechanisms such as denial, repression, regression, projection, compensation, projection, intellectualization, reaction formation, displacement, dissociation, and somatoform dissociation. We can distinguish healthy narcissism, an appropriate self-evaluation, from pathological narcissism, unrealistic self-evalutaion hiding sense of one's own unworthiness with self-idealization and grandiose thinking. When combined with low/no empathy and exploiting of others, one is diagnosed with narcissistic personality disorder. In this research we focused on narcissism as a personality trait, keeping in mind that we can differentiate between more covert or overt form of narcissism. We also focused on defense mechanisms protecting an individual from stimuli that are either endangering self-esteem or produce anxiety. Although their use is often unconscious, recent findings support the thesis that an individual can observe and report them. Our sample comprised 203 women. We used Narcissistic Personality Inventory, The Hypersensitive Narcissism Scale, The Life Style Index, The Dissociative Experience Scale, and Somatoform Dissociation Questionnaire. Results indicated that women with higher levels of covert narcissism as a personality trait use defense mechanisms, especially regression on earlier developmental stage, compensation deficits on other areas, projection unwanted or unacceptable aspects, reaction formation, and dissociation (absorption, depersonalization and derealization more often than women with higher levels of overt narcissism. The later use more compensation as a way of dealing with loss, intellectualization as a rational response instead of emotional one, and regression.

  11. Stop or move: Defensive strategies in humans.

    Science.gov (United States)

    Bastos, Aline F; Vieira, Andre S; Oliveira, Jose M; Oliveira, Leticia; Pereira, Mirtes G; Figueira, Ivan; Erthal, Fatima S; Volchan, Eliane

    2016-04-01

    Threatening cues and surrounding contexts trigger specific defensive response patterns. Potential threat evokes attentive immobility; attack evokes flight when escape is available and immobility when escape is blocked. Tonic immobility installs when threat is overwhelming and life-risky. In humans, reduced body sway characterizes attentive and tonic immobility, the former with bradycardia, and the later with expressive tachycardia. Here, we investigate human defensive strategies in the presence or absence of an escape route. We employed pictures depicting a man carrying a gun and worked with participants exposed to urban violence. In pictures simulating more possibility of escape, the gun was directed away from the observer; in those simulating higher risk and less chance of escape, the gun was directed toward the observer. Matched control pictures depicted similar layouts, but a non-lethal object substituted the gun. Posturographic and electrocardiographic recordings were collected. Amplitude of sway and heart rate were higher for gun directed-away and lower for gun direct-toward. Compared to their respective matched controls, there was a general increase in the amplitude of sway for the gun directed-away pictures; and a reduction in back-and-forth sway and in heart rate for gun directed-toward pictures. Taken together, those measures suggest that, when exposed to threat invading their margin of safety in a context indicating possible escape route, humans, as non-human species, engage in active escape, resembling the flight stage of the defensive cascade. When facing threat indicating less possibility of escape, humans present an immobile response with bradycardia.

  12. Directed energy missions for planetary defense

    Science.gov (United States)

    Lubin, Philip; Hughes, Gary B.; Eskenazi, Mike; Kosmo, Kelly; Johansson, Isabella E.; Griswold, Janelle; Pryor, Mark; O'Neill, Hugh; Meinhold, Peter; Suen, Jonathan; Riley, Jordan; Zhang, Qicheng; Walsh, Kevin; Melis, Carl; Kangas, Miikka; Motta, Caio; Brashears, Travis

    2016-09-01

    Directed energy for planetary defense is now a viable option and is superior in many ways to other proposed technologies, being able to defend the Earth against all known threats. This paper presents basic ideas behind a directed energy planetary defense system that utilizes laser ablation of an asteroid to impart a deflecting force on the target. A conceptual philosophy called DE-STAR, which stands for Directed Energy System for Targeting of Asteroids and exploration, is an orbiting stand-off system, which has been described in other papers. This paper describes a smaller, stand-on system known as DE-STARLITE as a reduced-scale version of DE-STAR. Both share the same basic heritage of a directed energy array that heats the surface of the target to the point of high surface vapor pressure that causes significant mass ejection thus forming an ejection plume of material from the target that acts as a rocket to deflect the object. This is generally classified as laser ablation. DE-STARLITE uses conventional propellant for launch to LEO and then ion engines to propel the spacecraft from LEO to the near-Earth asteroid (NEA). During laser ablation, the asteroid itself provides the propellant source material; thus a very modest spacecraft can deflect an asteroid much larger than would be possible with a system of similar mission mass using ion beam deflection (IBD) or a gravity tractor. DE-STARLITE is capable of deflecting an Apophis-class (325 m diameter) asteroid with a 1- to 15-year targeting time (laser on time) depending on the system design. The mission fits within the rough mission parameters of the Asteroid Redirect Mission (ARM) program in terms of mass and size. DE-STARLITE also has much greater capability for planetary defense than current proposals and is readily scalable to match the threat. It can deflect all known threats with sufficient warning.

  13. Optimal defense strategies in an idealized microbial food web under trade-off between competition and defense.

    Science.gov (United States)

    Våge, Selina; Storesund, Julia E; Giske, Jarl; Thingstad, T Frede

    2014-01-01

    Trophic mechanisms that can generate biodiversity in food webs include bottom-up (growth rate regulating) and top-down (biomass regulating) factors. The top-down control has traditionally been analyzed using the concepts of "Keystone Predation" (KP) and "Killing-the-Winner" (KtW), predominately occuring in discussions of macro- and micro-biological ecology, respectively. Here we combine the classical diamond-shaped food web structure frequently discussed in KP analyses and the KtW concept by introducing a defense strategist capable of partial defense. A formalized description of a trade-off between the defense-strategist's competitive and defensive ability is included. The analysis reveals a complex topology of the steady state solution with strong relationships between food web structure and the combination of trade-off, defense strategy and the system's nutrient content. Among the results is a difference in defense strategies corresponding to maximum biomass, production, or net growth rate of invading individuals. The analysis thus summons awareness that biomass or production, parameters typically measured in field studies to infer success of particular biota, are not directly acted upon by natural selection. Under coexistence with a competition specialist, a balance of competitive and defensive ability of the defense strategist was found to be evolutionarily stable, whereas stronger defense was optimal under increased nutrient levels in the absence of the pure competition specialist. The findings of success of different defense strategies are discussed with respect to SAR11, a highly successful bacterial clade in the pelagic ocean.

  14. Early Impact of a National Multi-Faceted Road Safety Intervention Program in Mexico: Results of a Time-Series Analysis

    Science.gov (United States)

    Chandran, Aruna; Pérez-Núñez, Ricardo; Bachani, Abdulgafoor M.; Híjar, Martha; Salinas-Rodríguez, Aarón; Hyder, Adnan A.

    2014-01-01

    Background In January 2008, a national multifaceted road safety intervention program (IMESEVI) funded by the Bloomberg Philanthropies was launched in Mexico. Two years later in 2010, IMESEVI was refocused as part of a 10-country international consortium demonstration project (IMESEVI/RS10). We evaluate the initial effects of each phase of the road safety intervention project on numbers of RT crashes, injuries and deaths in Mexico and in the two main target cities of Guadalajara-Zapopan and León. Methods An interrupted time series analysis using autoregressive integrated moving average (ARIMA) modeling was performed using monthly data of rates of RT crashes and injuries (police data), as well as deaths (mortality system data) from 1999–2011 with dummy variables representing each intervention phase. Results In the period following the first intervention phase at the country level and in the city of León, the rate of RT crashes decreased significantly (p<0.05). Notably, following the second intervention phase although there was no reduction at the country level, there has been a decrease in the RT crash rate in both Guadalajara-Zapopan (p = 0.029) and in León (p = 0.029). There were no significant differences in the RT injury or death rates following either intervention phase in either city. Conclusion These initial results suggest that a multi-faceted road safety intervention program appears to be effective in reducing road crashes in a middle-income country setting. Further analysis is needed to differentiate the effects of various interventions, and to determine what other economic and political factors might have affected this change. PMID:24498114

  15. A Multifaceted Approach to Reduction of Catheter-Associated Urinary Tract Infections in the Intensive Care Unit With an Emphasis on "Stewardship of Culturing".

    Science.gov (United States)

    Mullin, Katherine M; Kovacs, Christopher S; Fatica, Cynthia; Einloth, Colette; Neuner, Elizabeth A; Guzman, Jorge A; Kaiser, Eric; Menon, Venu; Castillo, Leticia; Popovich, Marc J; Manno, Edward M; Gordon, Steven M; Fraser, Thomas G

    2017-02-01

    BACKGROUND Catheter-associated urinary tract infections (CAUTIs) are among the most common hospital-acquired infections (HAIs). Reducing CAUTI rates has become a major focus of attention due to increasing public health concerns and reimbursement implications. OBJECTIVE To implement and describe a multifaceted intervention to decrease CAUTIs in our ICUs with an emphasis on indications for obtaining a urine culture. METHODS A project team composed of all critical care disciplines was assembled to address an institutional goal of decreasing CAUTIs. Interventions implemented between year 1 and year 2 included protocols recommended by the Centers for Disease Control and Prevention for placement, maintenance, and removal of catheters. Leaders from all critical care disciplines agreed to align routine culturing practice with American College of Critical Care Medicine (ACCCM) and Infectious Disease Society of America (IDSA) guidelines for evaluating a fever in a critically ill patient. Surveillance data for CAUTI and hospital-acquired bloodstream infection (HABSI) were recorded prospectively according to National Healthcare Safety Network (NHSN) protocols. Device utilization ratios (DURs), rates of CAUTI, HABSI, and urine cultures were calculated and compared. RESULTS The CAUTI rate decreased from 3.0 per 1,000 catheter days in 2013 to 1.9 in 2014. The DUR was 0.7 in 2013 and 0.68 in 2014. The HABSI rates per 1,000 patient days decreased from 2.8 in 2013 to 2.4 in 2014. CONCLUSIONS Effectively reducing ICU CAUTI rates requires a multifaceted and collaborative approach; stewardship of culturing was a key and safe component of our successful reduction efforts. Infect Control Hosp Epidemiol 2017;38:186-188.

  16. Designing a multifaceted quality improvement intervention in primary care in a country where general practice is seeking recognition: the case of Cyprus

    Directory of Open Access Journals (Sweden)

    Stoffers Henri E

    2008-08-01

    Full Text Available Abstract Background Quality Improvement Interventions require significant financial investments, and therefore demand careful consideration in their design in order to maximize potential benefits. In this correspondence we present the methodological approach of a multifaceted quality improvement intervention aiming to improve quality of care in primary care, properly tailored for a country such as Cyprus where general practice is currently seeking recognition. Methods Our methodological approach was focused on the design of an open label, community-based intervention controlled trial using all patients from two urban and two rural public primary care centers diagnosed with hypertension and type II diabetes mellitus. The design of our intervention was grounded on a strong theoretical framework that included the Unified Theory of Acceptance and Use of Technology, and the Chronic Care Model, which synthesize evidence-based system changes in accordance with the Theory of Planned Behavior and the Theory of Reasoned Action. The primary outcome measure was improvement in the quality of care for two chronic diseases evaluated through specific clinical indicators, as well as the patient satisfaction assessed by the EUROPEP questionnaire and additional personal interviews. Results We designed a multifaceted quality improvement intervention model, supported by a varying degree of scientific evidence, tailored to local needs and specific country characteristics. Overall, the main components of the intervention were the development and adoption of an electronic medical record and the introduction of clinical guidelines for the management of the targeted chronic diseases facilitated by the necessary model of organizational changes. Conclusion Health planners and policy makers need to be aware of the potential use of certain theoretical models and applied methodology as well as inexpensive tools that may be suitably tailored to the local needs, in order to

  17. Early impact of a national multi-faceted road safety intervention program in Mexico: results of a time-series analysis.

    Directory of Open Access Journals (Sweden)

    Aruna Chandran

    Full Text Available BACKGROUND: In January 2008, a national multifaceted road safety intervention program (IMESEVI funded by the Bloomberg Philanthropies was launched in Mexico. Two years later in 2010, IMESEVI was refocused as part of a 10-country international consortium demonstration project (IMESEVI/RS10. We evaluate the initial effects of each phase of the road safety intervention project on numbers of RT crashes, injuries and deaths in Mexico and in the two main target cities of Guadalajara-Zapopan and León. METHODS: An interrupted time series analysis using autoregressive integrated moving average (ARIMA modeling was performed using monthly data of rates of RT crashes and injuries (police data, as well as deaths (mortality system data from 1999-2011 with dummy variables representing each intervention phase. RESULTS: In the period following the first intervention phase at the country level and in the city of León, the rate of RT crashes decreased significantly (p<0.05. Notably, following the second intervention phase although there was no reduction at the country level, there has been a decrease in the RT crash rate in both Guadalajara-Zapopan (p = 0.029 and in León (p = 0.029. There were no significant differences in the RT injury or death rates following either intervention phase in either city. CONCLUSION: These initial results suggest that a multi-faceted road safety intervention program appears to be effective in reducing road crashes in a middle-income country setting. Further analysis is needed to differentiate the effects of various interventions, and to determine what other economic and political factors might have affected this change.

  18. A multifaceted feedback strategy alone does not improve the adherence to organizational guideline-based standards: a cluster randomized trial in intensive care.

    Science.gov (United States)

    de Vos, Maartje L G; van der Veer, Sabine N; Wouterse, Bram; Graafmans, Wilco C; Peek, Niels; de Keizer, Nicolette F; Jager, Kitty J; Westert, Gert P; van der Voort, Peter H J

    2015-07-08

    Organizational data such as bed occupancy rate and nurse-to-patient ratio are related to clinical outcomes and to the efficient use of intensive care unit (ICU) resources. Standards for these performance indicators are provided in guidelines. We studied the effects of a multifaceted feedback strategy to improve the adherence to these standards. In a cluster randomized controlled study design the intervention ICUs received extensive monthly feedback reports, they received outreach visits and initiated a quality improvement team. The control ICUs received limited quarterly feedback reports only. We collected primary data prospectively within the setting of a Dutch national ICU registry over a 14-month study period. The target indicators were bed occupancy rate (aiming at 80 % or below) and nurse-to-patient ratio (aiming at 0.5 or higher). Data were collected per 8-h nursing shift. Logistic regression analysis was performed. For both study end points, the odds ratios (OR) for improvements at follow-up versus at baseline were calculated separately for control and intervention ICUs. We analyzed data on 67,237 nursing shifts. The bed occupancy rate did not improve in the intervention group compared to baseline (adjusted OR 0.88; 95 % confidence interval (CI), 0.62-1.27) or compared to control group (OR 0.67; 95 % CI 0.39-1.15). The nurse-to-patient ratio did not improve (OR 0.72; 95 % CI 0.41-1.26 compared to baseline and OR 0.65; 95 % CI 0.35-1.19 compared to control group). A multifaceted feedback intervention did not improve the adherence to guideline-based standards on the organizational issues bed occupancy rate and nurse-to-patient ratio in the ICU. The reasons may be a limited confidence in data quality, the lack of practical tools for improvement, and the relatively short follow-up. ISRCTN50542146.

  19. The Reagan Defense Budget: Prospects and Pressures,

    Science.gov (United States)

    1981-12-01

    policy and to stimulate U.S. economic growth; and ( ii ) the urgent requirement to build up America’s defense capabilities. The former theme is a traditional...Paris in the Fall of 1981: a ver- sion of it will appear in the Ramses conference proceedings. -2- Unfortunately, it now seems as though these two...Proposed OMB Cut Alternatives (August) Level I 221.9 183.6 247.3 219.2 278.4 246.9 Level II 221.4 183.4 238.5 217.4 276.9 243.5 Level III 216.0 182.0

  20. The Relationship between Inflation and Defense Expenditures.

    Science.gov (United States)

    1979-12-01

    resources they would be bid up in the expanding sector. See Robert Solow , "Evaluation," in After the Phillips Curve: Persistence of High Inflation and...can be explained by the respective rates of growth of money supply per unit of national product. ’𔃼 IF’risch, op. cit., p. 1311. Robert J. Gordon...Statistical Approach for Forecasting Defense Expenditures in the Short-run," in William F. Butler, Robert A. Kavesh, and Robert B. Platt, eds., "Methods and

  1. Bacterial gasotransmitters: an innate defense against antibiotics.

    Science.gov (United States)

    Luhachack, Lyly; Nudler, Evgeny

    2014-10-01

    In recent decades, there has been growing interest in the field of gasotransmitters, endogenous gaseous signaling molecules (NO, H2S, and CO), as regulators of a multitude of biochemical pathways and physiological processes. Most of the concerted effort has been on eukaryotic gasotransmitters until the subsequent discovery of bacterial counterparts. While the fundamental aspects of bacterial gasotransmitters remain undefined and necessitate further research, we will discuss a known specific role they play in defense against antibiotics. Considering the current dilemma of multidrug-resistant bacteria we consider it particularly prudent to exploring novel targets and approaches, of which the bacterial gasotransmitters, nitric oxide and hydrogen sulfide represent.

  2. Who Pays for National Defense? Financing Defense Programs in the United States, 1947-2007

    Science.gov (United States)

    Heo, Uk; Bohte, John

    2012-01-01

    Past studies on military expenditures in the United States have primarily focused on the extent to which guns versus butter trade-offs are prevalent without examining this relationship in the context of how other fiscal policy tools are used to pay for defense. Using annual data from 1947-2007, this study examines the relative importance of…

  3. Defense Intelligence Agency: 50 Years Committed to Excellence in Defense of the Nation

    Science.gov (United States)

    2011-01-01

    to the September 11th terrorist attacks on the Pentagon. Rosa Chapa , Sandra Foster, Robert Hymel, Shelley Marshall, Patricia Mickley, Charles...the Nation MASTER SERGEANT WILLIAM W. BULTMEIER, USA, (RET) Defense Attaché Offi ce, Niamey 23 December 2000 ROSA M. CHAPA Offi ce of the Comptroller

  4. The silent defense: Micro-RNA directed defense against HIV-1 replication

    Directory of Open Access Journals (Sweden)

    Kumar Ajit

    2007-04-01

    Full Text Available Abstract MicroRNAs play critical role in regulating gene expression. MicroRNA profile of particular cell type bears the signature of cell type specific gene expression. Given that viral pathogens replicate by evading host defenses, research is now focused on the miRNA-regulated genes that critically regulate HIV-1 propagation in human host cells.

  5. Plant chemical defense against herbivores and pathogens: generalized defense or trade-offs?

    NARCIS (Netherlands)

    Biere, A.; Marak, H.B.; Van Damme, J.M.M.

    2004-01-01

    Plants are often attacked by multiple enemies, including pathogens and herbivores. While many plant secondary metabolites show specific effects toward either pathogens or herbivores, some can affect the performance of both these groups of natural enemies and are considered to be generalized defense

  6. Transitioning Defense Organizational Initiatives: An Assessment of Key 2001-2008 Defense Reforms

    Science.gov (United States)

    2008-12-01

    Pierre Chao Dr. Daniel Y. Chiu Mr. Raymond F. DuBois Ms. Michèle A. Flournoy Gen Ronald R. Fogleman, USAF (Ret.) Dr. Jacques S. Gansler Mr. Paul R.S...transformation was the Defense Business Board. First chaired by General Gus Pagonis (U. S. Army, Ret.), the chair since 2007 has been Michael Bayer . This

  7. Making Department of Defense Basic Research Purple (Joint), but NOT the Department of Defense Laboratories

    Science.gov (United States)

    2013-12-01

    outside of government, where they report to the chief executive officer (CEO) or to the CEO through a chief technology officer ( CTO ). The panel...Technology ASDR&E Assistant Secretary of Defense for Research and Engineering CEO chief executive officer COE Center of Excellence CTO chief

  8. 76 FR 44293 - Defense Acquisition Regulations System; Defense Federal Acquisition Regulation Supplement; Only...

    Science.gov (United States)

    2011-07-25

    ... presented by the Under Secretary of Defense for Acquisition, Technology, & Logistics in a memorandum dated... offered price. These provisions must also be used in acquisitions of commercial items conducted using part...--ACQUISITION OF COMMERCIAL ITEMS 4. Add new section 212.205 to read as follows: 212.205 Offers. (c) When...

  9. Defense Planning in the Ministry of Defense of Ukraine: Decade of Attempts and Mistakes

    Science.gov (United States)

    2015-06-01

    should be done by using the IAS for a modeling situation (for instance, JWARS—Joint Warfare System) or IAS which can carry out a SWOT analysis (IAS...43  C.  MISTAKE ANALYSIS OF CONDUCTED DEFENSE REVIEW IN MDU...PROGRAMS ...................................................64  B.  ANALYSIS OF PLANNING AND EXECUTING FINANCIAL RESOURCES OF MDU

  10. STUDY OF THE DEFENSIVE PERFORMANCE INDICATORS IN PEAK PERFORMANCE BASKETBALL

    Directory of Open Access Journals (Sweden)

    Alejandro \\u00C1lvarez

    2009-01-01

    Full Text Available The purpose of the present study was to analyze the different defensive performance indicators in basketball, analyzing the difference in relation to success (efficacious or non-efficacious defenses and the game result (win or loss. All halfcourt offenses (n=1045 from the quarterfinal, semifinal, consolation game, and final of the 2008 Olympics Games were analyzed. In each defense phase, the following variables were analyzed with regard to the team on defense: (1 Type of defense used, (2 Pressure in offense transition, (3 Defensive switches, (4 Helping on defense, (5 Inside passes, (6 Degree of opposition when shooting, (7 Points allowed, (8 Final result of the game, and (9 Defensive efficacy. The most significant results show that: : a the type of defense that was most used was quarter-court an-on-man (man-on-man at 6.25m, but the one that was most efficacious was the half-court zone defense; b transition pressure was used in 23.83% of the game phases; c defensive switches were done in 7.85% of the game phases; d helping on defense was used in 60% of the game phases; e inside passes were taken in 30.9% of the game phases; f 38.9% of the shots were done with high opposition; and g points were scored in 42.28% of the game phases, such that winning teams allowed the opponent to score in 38.81% of the game phases, and losing teams in 45.77%.

  11. Extracellular Alkalinization as a Defense Response in Potato Cells

    OpenAIRE

    Moroz, Natalia; Fritch, Karen R.; Marcec, Matthew J.; Tripathi, Diwaker; Smertenko, Andrei; Tanaka, Kiwamu

    2017-01-01

    A quantitative and robust bioassay to assess plant defense response is important for studies of disease resistance and also for the early identification of disease during pre- or non-symptomatic phases. An increase in extracellular pH is known to be an early defense response in plants. In this study, we demonstrate extracellular alkalinization as a defense response in potatoes. Using potato suspension cell cultures, we observed an alkalinization response against various pathogen- and plant-de...

  12. Deming's Management Philosophy and the defense industrial base.

    OpenAIRE

    Graff, David Jacques

    1991-01-01

    Approved for public release: distribution is unlimited The purpose of this thesis is to analyze why firms are leaving the defense industrial base and to determine if Dr. Edwards Deming's Management Philosophy can offer a more constructive way of doing business in the Defense Acquisition System. A comparative analysis was conducted between industry's reasons for wanting to leave the defense sector and Deming's Management Philosophy. This analysis determined if adoption of Deming's Managemen...

  13. Assessing Future Trends in the Defense Burdens of Western Nations

    Science.gov (United States)

    1993-04-01

    Summary Table 1). A weighted average for the four allies that spend most heavily on defense -- Japan , France, Germany, and the United Kingdom--is projected...military was dismantled. Among the largest allies, Japan represents the other extreme. Japanese defense spending as a percentage of GDP is projected to...January 1993. d. Weighted average for Japan , France, Germany, and the United Kingdom--countries that spend the greatest amounts on defense . e The 1990

  14. Defense Exportability Features Initiative: A New Paradigm for International Cooperation

    Science.gov (United States)

    2015-02-01

    exportability process. Consequently DEF should en- hance these traditional benefits in two important ways: • By providing advanced capability to allies and...Defense AT&L: January–February 2015 24 Defense Exportability Features Initiative A New Paradigm for International Cooperation Frank D. Kenlon n...Jay Mandelbaum Kenlon is a professor of international acquisition management (intermittent) in the Defense Systems Management College’s International

  15. Analysis of Defense Products Contract Trends, 1990-2014

    Science.gov (United States)

    2015-04-30

    Analysis of Defense Products Contract Trends , 1990–2014 Andrew Hunter—is a senior fellow in the International Security Program and director of the Defense...a decade, the Defense-Industrial Initiatives Group at the Center for Strategic and International Studies (CSIS) has analyzed and reported on trends ...countervailing trend of divestments, including Northrop Grumman’s divestment of its shipbuilding business into Huntington Ingalls Industries. As

  16. Defense: FY2012 Budget Request, Authorization and Appropriations

    Science.gov (United States)

    2012-02-13

    Senate versions of the bill would have done). The ships for which most of the total cost is authorized in FY2012 include two Virginia -class submarines, a...New START Treaty: Central Limits and Key Provisions, by Amy F. Woolf . Defense: FY2012 Budget Request, Authorization and Appropriations...Missile Defense and Offensive Arms Reductions: A Review of the Historical Record, by Steven A. Hildreth and Amy F. Woolf . Defense: FY2012 Budget

  17. Department of Defense Laboratories: Finding a Future in Technology Transfer

    Science.gov (United States)

    1993-04-01

    investment. There is no mention of DoD even trying. This, then, presents a problem for Defense technology transfer management. The President expects both...effort, but nonetheless felt unable to express their effort quantitatively. The potential size and demand for Defense technology transfer calls for some... Defense technology transfer is taking place, it is doing so on the enthusiasm and drive of a few key individuals. Political demand and legislation

  18. Total Quality Management in the Department of Defense

    Science.gov (United States)

    1989-09-01

    DTI ELECT SDu TOTAL QUALITY MANAGEMENT IN THE DEPARTMENT OF DEFENSE THESIS BRUCE E. SPRINGS, B.S. CAPTAIN, USAF AFIT/GLN/LSR/ 89S -57 I1- DEPARTMENT...13 0 3 AFIT/GLM/LSR/89S-57 TOTAL QUALITY MANAGEMENT IN THE DEPARTMENT OF DEFENSE THESIS BRUCE E. SPRINGS, B.S. CAPTAIN, USAF AFIT/GLH/LSR/89S-57...Defense. # AFIT/GLM/LSR/89S-57 TOTAL QUALITY MANAGEMENT IN THE DEPARTMENT OF DEFENSE THESIS Presented to the Faculty of the School of Systems and Logistics

  19. Defense strategies used by two sympatric vineyard moth pests.

    Science.gov (United States)

    Vogelweith, Fanny; Thiéry, Denis; Moret, Yannick; Colin, Eloïse; Motreuil, Sébastien; Moreau, Jérôme

    2014-05-01

    Natural enemies including parasitoids are the major biological cause of mortality among phytophagous insects. In response to parasitism, these insects have evolved a set of defenses to protect themselves, including behavioral, morphological, physiological and immunological barriers. According to life history theory, resources are partitioned to various functions including defense, implying trade-offs among defense mechanisms. In this study we characterized the relative investment in behavioral, physical and immunological defense systems in two sympatric species of Tortricidae (Eupoecilia ambiguella, Lobesia botrana) which are important grapevine moth pests. We also estimated the parasitism by parasitoids in natural populations of both species, to infer the relative success of the investment strategies used by each moth. We demonstrated that larvae invest differently in defense systems according to the species. Relative to L. botrana, E. ambiguella larvae invested more into morphological defenses and less into behavioral defenses, and exhibited lower basal levels of immune defense but strongly responded to immune challenge. L. botrana larvae in a natural population were more heavily parasitized by various parasitoid species than E. ambiguella, suggesting that the efficacy of defense strategies against parasitoids is not equal among species. These results have implications for understanding of regulation in communities, and in the development of biological control strategies for these two grapevine pests.

  20. Law & psychiatry: Does the constitution require an insanity defense?

    Science.gov (United States)

    Appelbaum, Paul S

    2013-10-01

    Idaho is one of four states that have abolished the insanity defense. Hence, John Delling, on trial for two murders in Idaho, was unable to plead insanity or to argue that he lacked intent to kill, the only available option under Idaho law. After being sentenced to life in prison without parole, Delling challenged the constitutionality of Idaho's law. The state's supreme court rejected his appeal, holding that--despite the long history of the insanity defense and its widespread acceptance--there was no constitutional right to an insanity defense. Delling's petition to the U.S. Supreme Court was turned away, leaving the constitutional status of the insanity defense uncertain.

  1. Plant antiherbivore defenses in Fabaceae species of the Chaco

    Directory of Open Access Journals (Sweden)

    T. E. Lima

    Full Text Available Abstract The establishment and maintenance of plant species in the Chaco, one of the widest continuous areas of forests in the South American with sharp climatic variations, are possibly related to biological features favoring plants with particular defenses. This study assesses the physical and chemical defenses mechanisms against herbivores of vegetative and reproductive organs. Its analyses of 12 species of Fabaceae (Leguminosae collected in remnants of Brazilian Chaco shows that 75% present structural defense characters and 50% have chemical defensedefense proteins in their seeds, like protease inhibitors and lectins. Physical defenses occur mainly on branches (78% of the species, leaves (67%, and reproductive organs (56%. The most common physical characters are trichomes and thorns, whose color represents a cryptic character since it does not contrast with the other plant structures. Defense proteins occur in different concentrations and molecular weight classes in the seeds of most species. Protease inhibitors are reported for the first time in seeds of: Albizia niopoides, Anadenanthera colubrina, Mimosa glutinosa, Prosopis rubriflora, and Poincianella pluviosa. The occurrence of physical and chemical defenses in members of Fabaceae indicate no associations between defense characters in these plant species of the Chaco.

  2. 75 FR 5289 - Defense Health Board (DHB) Meeting

    Science.gov (United States)

    2010-02-02

    ... Defense Health Board Subcommittees will present updates to the Board: National Capital Region Base... Forces, Military/ Occupational Health and Medical Surveillance, and the Psychological Health...

  3. Does self-defense training prevent sexual violence against women?

    Science.gov (United States)

    Hollander, Jocelyn A

    2014-03-01

    Self-defense classes are offered across the nation as a strategy for reducing women's vulnerability to sexual assault. Yet there has been little systematic research assessing the effectiveness of these classes. In this article, I use data from a mixed methods study of a 10-week, university-based, feminist self-defense class to examine the effectiveness of self-defense training over a 1-year follow-up period. My analyses indicate that women who participate in self-defense training are less likely to experience sexual assault and are more confident in their ability to effectively resist assault than similar women who have not taken such a class.

  4. Mental imagery affects subsequent automatic defense responses

    Directory of Open Access Journals (Sweden)

    Muriel A Hagenaars

    2015-06-01

    Full Text Available Automatic defense responses promote survival and appropriate action under threat. They have also been associated with the development of threat-related psychiatric syndromes. Targeting such automatic responses during threat may be useful in populations with frequent threat exposure. Here, two experiments explored whether mental imagery as a pre-trauma manipulation could influence fear bradycardia (a core characteristic of freezing during subsequent analogue trauma (affective picture viewing. Image-based interventions have proven successful in the treatment of threat-related disorders, and are easily applicable. In Experiment 1 43 healthy participants were randomly assigned to an imagery script condition. Participants executed a passive viewing task with blocks of neutral, pleasant and unpleasant pictures after listening to an auditory script that was either related (with a positive or a negative outcome or unrelated to the unpleasant pictures from the passive viewing task. Heart rate was assessed during script listening and during passive viewing. Imagining negative related scripts resulted in greater bradycardia (neutral-unpleasant contrast than imagining positive scripts, especially unrelated. This effect was replicated in Experiment 2 (N = 51, again in the neutral-unpleasant contrast. An extra no-script condition showed that bradycardia was not induced by the negative related script, but rather that a positive script attenuated bradycardia. These preliminary results might indicate reduced vigilance after unrelated positive events. Future research should replicate these findings using a larger sample. Either way, the findings show that highly automatic defense behavior can be influenced by relatively simple mental imagery manipulations.

  5. Antioxidative defense mechanisms in the aging brain

    Directory of Open Access Journals (Sweden)

    Jovanović Zorica

    2014-01-01

    Full Text Available Aging is an extremely complex, multifactorial process that is characterized by a gradual and continuous loss of physiological functions and responses, particularly marked in the brain. A common hallmark in aging and age-related diseases is an increase in oxidative stress and the failure of antioxidant defense systems. Current knowledge indicates that the level of glutathione progressively declines during aging. Because nerve cells are the longest-living cells that exhibit a high consumption rate of oxygen throughout an individual’s lifetime, the brain may be especially vulnerable to oxidative damage and this vulnerability increases during aging. In addition, the brain contains high concentrations of polyunsaturated fatty acids and transition metals and low antioxidative defense mechanisms. Although aging is an inevitable event, a growing volume of data confirms that antioxidant supplementation in combination with symptomatic drug treatments reduces oxidative stress and improves cognitive function in aging and age-related diseases. The present review discusses the neuroprotective effects of antioxidants in the aging brain.

  6. Directed Energy Missions for Planetary Defense

    CERN Document Server

    Lubin, Philip; Eskenazi, Mike; Kosmo, Kelly; Johansson, Isabella E; Griswold, Janelle; Pryor, Mark; O'Neill, Hugh; Meinhold, Peter; Suen, Jonathon; Riley, Jordan; Zhang, Qicheng; Walsh, Kevin; Melis, Carl; Kangas, Miikka; Motta, Caio; Brashears, Travis

    2016-01-01

    Directed energy for planetary defense is now a viable option and is superior in many ways to other proposed technologies, being able to defend the Earth against all known threats. This paper presents basic ideas behind a directed energy planetary defense system that utilizes laser ablation of an asteroid to impart a deflecting force on the target. A conceptual philosophy called DE-STAR, which stands for Directed Energy System for Targeting of Asteroids and exploRation, is an orbiting stand-off system, which has been described in other papers. This paper describes a smaller, stand-on system known as DE-STARLITE as a reduced-scale version of DE-STAR. Both share the same basic heritage of a directed energy array that heats the surface of the target to the point of high surface vapor pressure that causes significant mass ejection thus forming an ejection plume of material from the target that acts as a rocket to deflect the object. This is generally classified as laser ablation. DE-STARLITE uses conventional prop...

  7. Beryllium--important for national defense

    Science.gov (United States)

    Boland, M.A.

    2012-01-01

    Beryllium is one of the lightest and stiffest metals, but there was little industrial demand for it until the 1930s and 1940s when the aerospace, defense, and nuclear sectors began using beryllium and its compounds. Beryllium is now classified by the U.S. Department of Defense as a strategic and critical material because it is used in products that are vital to national security. The oxide form of beryllium was identified in 1797, and scientists first isolated metallic beryllium in 1828. The United States is the world's leading source of beryllium. A single mine at Spor Mountain, Utah, produced more than 85 percent of the beryllium mined worldwide in 2010. China produced most of the remainder, and less than 2 percent came from Mozambique and other countries. National stockpiles also provide significant amounts of beryllium for processing. To help predict where future beryllium supplies might be located, U.S.Geological Survey (USGS) scientists study how and where beryllium resources are concentrated in Earth's crust and use that knowledge to assess the likelihood that undiscovered beryllium resources may exist. Techniques to assess mineral resources have been developed by the USGS to support the stewardship of Federal lands and to better evaluate mineral resource availability in a global context. The USGS also compiles statistics and information on the worldwide supply of, demand for, and flow of beryllium. These data are used to inform U.S. national policymaking.

  8. Utilizing Multifaceted Rasch Measurement through Facets to Evaluate Science Education Data Sets Composed of Judges, Respondents, and Rating Scale Items: An Exemplar Utilizing the Elementary Science Teaching Analysis Matrix Instrument

    Science.gov (United States)

    Boone, William J.; Townsend, J. Scott; Staver, John R.

    2016-01-01

    When collecting data, science education researchers frequently have multiple respondents evaluate multiple artifacts using multiple criteria. Herein, the authors introduce Multifaceted Rasch Measurement (MFRM) analysis and explain why MFRM must be used when "judges'" data are collected. The authors use data from elementary science…

  9. Stress Prevention@Work : A study protocol for the evaluation of a multifaceted integral stress prevention strategy to prevent employee stress in a healthcare organization: a cluster controlled trial

    NARCIS (Netherlands)

    Hoek, R.J.A.; Havermans, B.M.; Houtman, I.L.D.; Brouwers, E.P.M.; Heerkens, Y.F.; Zijlstra-vlasveld, M.C.; Anema, J.R.; van der Beek, A.J.; Boot, C.R.L.

    2018-01-01

    Adequate implementation of work-related stress management interventions can reduce or prevent work-related stress and sick leave in organizations. We developed a multifaceted integral stress-prevention strategy for organizations from several sectors that includes a digital platform and collaborative

  10. Defense Headquarters: Improved Data Needed to Better Identify Streamlining and Cost Savings Opportunities by Function

    Science.gov (United States)

    2016-06-01

    approaches from the commercial sector to the department’s six core business processes— management of human resources , healthcare, financial flow... human resource programs for nonappropriated funds, and centrally managed information technology functions. Most of the personnel involved in these...Defense Contract Management Agency • Defense Finance and Accounting Service • Defense Health Agency • Defense Human Resource Activity • Defense

  11. 32 CFR 37.1030 - What information must I report to the Defense Technical Information Center?

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false What information must I report to the Defense Technical Information Center? 37.1030 Section 37.1030 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Executing...

  12. 77 FR 29443 - 60-Day Notice of Two Proposed Directorate of Defense Trade Controls Information Collections...

    Science.gov (United States)

    2012-05-17

    ... collection: The export, temporary import, temporary export and brokering of defense articles, defense... Export Control Act. Those of the public who manufacture or export defense articles, defense services, and... personal delivery. Dated: May 14, 2012. Robert S. Kovac, Managing Director of Defense Trade...

  13. Survey of Laboratories and Implementation of the Federal Defense Laboratory Diversification Program

    Science.gov (United States)

    1994-02-01

    Defense Technology Transfer Working Group AGENCY...Director, Defense Research and Engineering. ACTION: solicitation in inputs for defense technology transfer . The Defense Technology Transfer Working...DAILY, 2.3 July 1993 Detense Nuclear Agency, 6801 Telegraph Road, Alexandria,, VA 22310D-3398 A - SOURCES SOUGHT FOR INPUTS FOR DEFENSE TECHNOLOGY TRANSFER

  14. Defense Acquisition Research Journal. Volume 23, Number 3, Issue 78, July 2016

    Science.gov (United States)

    2016-07-01

    for National Security and Resource Strategy Dr. J. Ronald Fox Harvard Business School Mr. David Gallop Defense Acquisition University Dr. Jacques...Predator: The Secret Origins of the Drone Revolution Written by Richard Whittle Reviewed by Julien Demotes-Mainard Mr. Patrick Fitzgerald Defense...Defense Acquisition Research Journal, formerly the Defense Acquisition Review Journal, is published quarterly by the Defense Acquisition University (DAU

  15. Defense of breast cancer malpractice claims.

    Science.gov (United States)

    Zylstra, S; D'Orsi, C J; Ricci, B A; Halloran, E E; Resseguie, L J; Greenwald, L; Mondor, M C

    2001-01-01

    The goal of this study was to determine whether factors associated with the successful defense and cost of malpractice cases involving the failure to diagnose breast cancer could be identified in medical and legal records. Secondary goals were to develop a multidisciplinary clinical algorithm utilizing National Comprehensive Cancer Network (NCCN) practice guidelines with practitioner risk management strategies. Physician deviations from these guidelines were tracked to identify high-risk areas in the diagnosis of breast cancer. A multidisciplinary clinical algorithm was introduced and practitioner risk management issues were addressed. In this study specific medical, legal, and cost factors were retrospectively abstracted and analyzed to identify associations between medical and legal factors and medicolegal outcome. ProMutual handled 156 malpractice cases involving breast cancer between January 22, 1986, and November 20, 1997. Of the total, 124 cases involving 212 defendants were closed. The closed cases were analyzed, using multivariable stepwise logistic and linear regression, to identify associations between clinical factors and case outcome. Women's health practitioners (WHPs), including obstetrician-gynecologists (OB-GYNs), family medicine, and internal medicine clinicians, were the largest group of defendants (97). Others included radiologists (43), surgeons (33), and pathologists (3). OB-GYNs accounted for 31% of these defendants, with a cost of more than $16 million. The greatest number of specialists represented in the open cases were radiologists, with 38% of the total. The defense model predicts that the probability of successful defense is lessened with inadequate record keeping, a patient that has metastasis and is alive, and a delay in diagnosis of 12 months or more. The overall indemnity model predicts a higher indemnity with the spread of disease at the time of evaluation, a patient who has metastasis and is alive, and a date of occurrence closer

  16. 29 CFR 790.13 - General nature of defense.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false General nature of defense. 790.13 Section 790.13 Labor... Administrative Regulations, Etc. § 790.13 General nature of defense. (a) Under the provisions of sections 9 and... recognition by Congress of the remedial nature of the Fair Labor Standards Act and of the need...

  17. Applications of spatially offset Raman spectroscopy to defense and security

    Science.gov (United States)

    Guicheteau, Jason; Hopkins, Rebecca

    2016-05-01

    Spatially offset Raman spectroscopy (SORS) allows for sub-surface and through barrier detection and has applications in drug analysis, cancer detection, forensic science, as well as defense and security. This paper reviews previous efforts in SORS and other through barrier Raman techniques and presents a discussion on current research in defense and security applications.

  18. Common loon nest defense against an American mink

    Science.gov (United States)

    McCarthy, Kyle P.; Destefano, Stephen

    2011-01-01

    We describe a successful nest defense strategy of an adult Gavia immer (Common Loon) during an attempted predation event by a Nevison vison (American Mink) at Umbagog National Wildlife Refuge, NH. It is suspected that mink occasionally depredate loon nests, but defense strategies have not been described previously.

  19. Influence of Organisational Defensive Patterns on Learning ICT

    Science.gov (United States)

    Yau, Hon Keung; Cheng, Alison Lai Fong

    2011-01-01

    Purpose: The purpose of this paper is to investigate whether the IT professionals in a Hong Kong public transport company have a general perception of influence of the organisational defensive patterns on learning of ICT; and whether skilled incompetence, organisational defensive routines and fancy footwork are positively associated with each…

  20. 76 FR 2246 - Defense Support of Civil Authorities (DSCA)

    Science.gov (United States)

    2011-01-13

    ... made the existing guidance outdated and inconsistent with current law and the current organizational structure of the Department of Defense. This final rule will facilitate civil authorities' access to the... Activities, and all other organizational entities within the Department of Defense (hereafter referred to...

  1. Molecular mechanisms of epithelial host defense in the airways

    NARCIS (Netherlands)

    Vos, Joost Bastiaan

    2007-01-01

    Airway epithelial cells are indispensable for the host defense system in the lungs. Various strategies by which epithelial cells protect the lungs against inhaled pathogens have been described. In spite of that, the molecular mechanisms by which epithelial cells initiate and control the host defense

  2. Defense Acquisition Research Journal. Volume 21, Number 1, Issue 68

    Science.gov (United States)

    2014-01-01

    exclusivity and the egos of A Publication of the Defense Acquisition University http://www.dau.mil 477 Defense ARJ, January 2014, Vol. 21 No. 1: 466–484...the decreasing strength of their fleet relative to Japan’s. As Professor John Kuehn emphasizes, this multidimensional threat drasti- cally altered

  3. 75 FR 9399 - Defense Health Board (DHB) Meeting

    Science.gov (United States)

    2010-03-02

    ...: Notice of meeting. SUMMARY: Pursuant to the Federal Advisory Committee Act of 1972 (5 U.S.C., Appendix as... Prevention of Suicide by Members of the Armed Forces, a subcommittee of the Defense Health Board (DHB), will..., Department of Defense Task Force on the Prevention of Suicide by Members of the Armed Forces, One Skyline...

  4. Deception used for Cyber Defense of Control Systems

    Energy Technology Data Exchange (ETDEWEB)

    Wayne F. Boyer; Miles A. McQueen

    2009-05-01

    Control system cyber security defense mechanisms may employ deception to make it more difficult for attackers to plan and execute successful attacks. These deceptive defense mechanisms are organized and initially explored according to a specific deception taxonomy and the seven abstract dimensions of security previously proposed as a framework for the cyber security of control systems.

  5. Climate Change Impacts at Department of Defense Installations

    Science.gov (United States)

    2017-06-16

    ANL/EVS-17/9 Climate Change Impacts at Department of Defense Installations Environmental Science Division About...LLC. June 16, 2017 ANL/EVS-17/9 Climate Change Impacts at Department of Defense Installations prepared by Rao Kotamarthi...7 3.2 Use of Weather Data and Views on Climate Change among the DoD Site Contacts

  6. Molecular sabotage of host plant defenses by spider mites

    NARCIS (Netherlands)

    Villarroel Figueroa, C.A.

    2016-01-01

    Plants constitute an ample source of nutrients for a diversity of organisms that include viruses, microbes, nematodes, insects, and mites. To protect their resources, plants possess a robust immune system that establishes structural and biochemical defenses to fight invaders. Some of these defenses

  7. 78 FR 21826 - Defense Support of Civilian Law Enforcement Agencies

    Science.gov (United States)

    2013-04-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary 32 CFR Part 182 Defense Support of Civilian Law Enforcement Agencies AGENCY... piracy operations conducted pursuant to title 10, U.S.C. Sec. 182.3 Definitions. The...

  8. Defense Spending and the Economy - An Econometric View

    Science.gov (United States)

    1994-01-01

    spend the peace dividend. Most people expect that dividend to be generated by improvements in the economy fueled by reductions in defense expenditure...There have been a myriad of articles written regarding the effects defense spending has on the economy . Many of the authors of these articles disagree

  9. The Personality Assessment Inventory (PAI) and the Detection of Defensiveness.

    Science.gov (United States)

    Cashel, Mary Louise; And Others

    1995-01-01

    The use of scales on the Personality Assessment Inventory (PAI) to detect defensiveness in criminal and nonclinical samples was evaluated with 45 male inmates and 38 male undergraduates under standard conditions or under instructions to feign a positive role. Results indicate that the PAI is susceptible to defensive dissimulation. (SLD)

  10. Defensive Operations in a Decisive Action Training Environment

    Science.gov (United States)

    2017-07-01

    Operations in a Decisive Action Training Environment Christopher L. Vowels W. Anthony Scroggins U.S. Army Research Institute Captain Kyle T...7260 Alabama Avenue Fort Polk, LA 71459 ii Research Report 2003 Defensive Operations in a Decisive Action Training Environment...the entirety of the project and his guidance ensured the research was successful. iv DEFENSIVE OPERATIONS IN A DECISIVE ACTION TRAINING

  11. Defense Infrastructure: Actions Needed to Strengthen Utility Resilience Planning

    Science.gov (United States)

    2016-11-01

    DEFENSE INFRASTRUCTURE Actions Needed to Strengthen Utility Resilience Planning Report to the Committee on Armed...to Strengthen Utility Resilience Planning What GAO Found Based on GAO’s survey of Department of Defense (DOD) owned utility systems, there were...Evaluation 40 Appendix I Scope and Methodology 42 Appendix II Survey on DOD-Owned Utility Resilience 48 Appendix III Comments from the

  12. Natural enemies drive geographic variation in plant defenses

    DEFF Research Database (Denmark)

    Zuest, Tobias; Heichinger, Christian; Grossniklaus, Ueli

    2012-01-01

    Plants defend themselves against attack by natural enemies, and these defenses vary widely across populations. However, whether communities of natural enemies are a sufficiently potent force to maintain polymorphisms in defensive traits is largely unknown. Here, we exploit the genetic resources o...

  13. Willingness to pay for defense against weapons of mass destruction.

    Science.gov (United States)

    Mulvaney, J M; LaBarre, D; Pastel, R; Landauer, M

    2001-12-01

    A survey assessed the willingness to pay for defense against weapons of mass destruction. The results were evaluated according to the benefit to society. The results indicated preferences for increased spending on intelligence gathering, training, and equipment. We concluded that the United States is spending less for weapons of mass destruction defense than the sample population was willing to pay.

  14. Polyphenol Oxidase as a Biochemical Seed Defense Mechanism

    Directory of Open Access Journals (Sweden)

    E. Patrick Fuerst

    2014-12-01

    Full Text Available Seed dormancy and resistance to decay are fundamental survival strategies, which allow a population of seeds to germinate over long periods of time. Seeds have physical, chemical, and biological defense mechanisms that protect their food reserves from decay-inducing organisms and herbivores. Here, we hypothesize that seeds also possess enzyme-based biochemical defenses, based on induction of the plant defense enzyme, polyphenol oxidase (PPO, when wild oat (Avena fatua L. caryopses and seeds were challenged with seed-decaying Fusarium fungi. These studies suggest that dormant seeds are capable of mounting a defense response to pathogens. The pathogen-induced PPO activity from wild oat was attributed to a soluble isoform of the enzyme that appeared to result, at least in part, from proteolytic activation of a latent PPO isoform. PPO activity was also induced in wild oat hulls (lemma and palea, non-living tissues that cover and protect the caryopsis. These results are consistent with the hypothesis that seeds possess inducible enzyme-based biochemical defenses arrayed on the exterior of seeds and these defenses represent a fundamental mechanism of seed survival and longevity in the soil. Enzyme-based biochemical defenses may have broader implications since they may apply to other defense enzymes as well as to a diversity of plant species and ecosystems.

  15. Department of Defense Homeland Security Joint Operating Concept

    Science.gov (United States)

    2004-02-01

    electronic warfare, physical attack and/or destruction, and special information operations, and could include computer network attack.”19 In 2015...electronic warfare, and special information operations. Defensive information operations ensure timely, accurate, and relevant information access while...security, counter-deception, counter- psychological operations, counter-intelligence, electronic warfare, and special information operations. Defensive

  16. Department of Defense Management of Unobligated Funds for Acquisition Programs

    Science.gov (United States)

    2015-04-30

    CGFM, MBA, Senior Staff Accountant, Office of the Under Secretary of Defense (Comptroller), Financial Improvement and Audit Readiness (FIAR), 703...This research analyzes financial obligation rates for acquisition programs and acquisition program contract awards made in the last quarter of the...Postgraduate School since September 2010. Prior to that, he taught acquisition and business, cost estimating, and financial management courses at the Defense

  17. Defense Reform: An Out of the Box Approach.

    Science.gov (United States)

    2007-11-02

    O’Hanlon, Michael, Defense Planning for the Late 1990s, Beyond the Desert Storm Framework, Brookings, 1995, page 34 Ibid., page 31 Muradian, Vago ...Closure Rounds", GAO/NSIAD-97-151. May 1997 Muradian, Vago , "Bumpers Questions Navy of F/A-18E/F, Overall Shipbuilding Plan", Defense Daily. 12

  18. Silicon-inducible defenses of Zinnia elegans against Myzus persicae

    Science.gov (United States)

    Several examples exist of silicon (Si) amendment inducing plant chemical defenses against plant pathogens, but few studies have focused on Si-induced defenses against phloem-feeding herbivores. The current study examined Si treatment of Zinnia elegans Jacq. cv. Oklahoma White (Compositae) on the pe...

  19. Globalization and Its Implications for the Defense Industrial Base

    Science.gov (United States)

    2007-02-01

    pursued three strategies: buying relatively small defense units from diversified U.S. conglomerates (like General Motors and TRW); acquiring defense...13.9 percent).121 European companies have been very successful in China: Volkswagen makes the country’s most popular brand of cars, and Siemens is the

  20. 41 CFR 60-300.22 - Direct threat defense.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Direct threat defense. 60-300.22 Section 60-300.22 Public Contracts and Property Management Other Provisions Relating to Public... VETERANS Discrimination Prohibited § 60-300.22 Direct threat defense. The contractor may use as...

  1. 41 CFR 60-250.22 - Direct threat defense.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Direct threat defense. 60-250.22 Section 60-250.22 Public Contracts and Property Management Other Provisions Relating to Public... VETERANS Discrimination Prohibited § 60-250.22 Direct threat defense. The contractor may use as...

  2. A Forensic Psychology Exercise: Role Playing and the Insanity Defense.

    Science.gov (United States)

    Fass, Michael E.

    1999-01-01

    Presents a role playing exercise that provides students with an introduction to forensic psychology and the insanity defense. Reports that 87% of the students found this exercise to be an enjoyable teaching technique and useful in providing an understanding of the insanity defense. Concludes that the exercise increases student interest and…

  3. Department of Defense Dictionary of Military and Associated Terms

    Science.gov (United States)

    2016-02-15

    distribution and deployment. f. level VI - personnel: detail expressed by name, Service , military occupational specialty and unique identification...of one or more weapons with all related equipment, materials, services , personnel, and means of delivery and deployment (if applicable) required for...2016 A-46 JP 1-02 DCRF defense chemical, biological, radiological, and nuclear response force DCS Defense Courier Service ; deputy chief

  4. 77 FR 46425 - Federal Advisory Committee; Defense Health Board Meeting

    Science.gov (United States)

    2012-08-03

    ... of the Secretary Federal Advisory Committee; Defense Health Board Meeting AGENCY: Department of Defense (DoD). ACTION: Notice of meeting. SUMMARY: Pursuant to the Federal Advisory Committee Act of 1972... amended), and 41 CFR 102-3.150, and in accordance with section 10(a)(2) of Public Law, a meeting of...

  5. Handbook of cosmic hazards and planetary defense

    CERN Document Server

    Allahdadi, Firooz

    2015-01-01

    Covers in a comprehensive fashion all aspects of cosmic hazards and possible strategies for contending with these threats through a comprehensive planetary defense strategy. This handbook brings together in a single reference work a rich blend of information about the various types of cosmic threats that are posed to human civilization by asteroids, comets, bolides, meteors, solar flares and coronal mass ejections, cosmic radiation and other types of threats that are only recently beginning to be understood and studied, such as investigation of the “cracks” in the protective shield provided by the Van Allen belts and the geomagnetosphere, of matter-antimatter collisions, orbital debris and radiological or biological contamination. Some areas that are addressed involve areas about which there is a good deal of information that has been collected for many decades by multiple space missions run by many different space agencies, observatories and scientific researchers. Other areas involving research and ...

  6. Issues in defense training systems immersive displays

    Science.gov (United States)

    Gaylord, Philip

    2006-05-01

    Display technology for DOD immersive projector-based flight training systems are at a crossroads as CRT technology slowly disappears from the market place. From the DOD perspective, emerging technologies arrive poorly matched to satisfy training needs. The DOD represents a minority voice in the marketplace. Current issues include: Satisfying requirements for black level, brightness and contrast ratio, Establishing standard metrics for resolution, system performance and reliability, Obtaining maintainability and self-calibration in multi-channel arrays, Reducing screen cross-reflection in wrap-around immersive display arrays. Laser, DLP, and LCOS projector systems are compared for their current acceptance and problems in defense flight training systems. General requirements of visual display systems are discussed and contrasted for flight trainers for low flyers (helicopters) high flyers (tactical aircraft) in real-time immersive, networked systems. FLIR and NVG simulation techniques are described.

  7. Animal defense strategies and anxiety disorders

    Directory of Open Access Journals (Sweden)

    Rosana Shuhama

    2007-03-01

    Full Text Available Anxiety disorders are classified according to symptoms, time course and therapeutic response. Concurrently, the experimental analysis of defensive behavior has identified three strategies of defense that are shared by different animal species, triggered by situations of potential, distal and proximal predatory threat, respectively. The first one consists of cautious exploration of the environment for risk assessment. The associated emotion is supposed to be anxiety and its pathology, Generalized Anxiety Disorder. The second is manifested by oriented escape or by behavioral inhibition, being related to normal fear and to Specific Phobias, as disorders. The third consists of disorganized flight or complete immobility, associated to dread and Panic Disorder. Among conspecific interactions lies a forth defense strategy, submission, that has been related to normal social anxiety (shyness and to Social Anxiety Disorder. In turn, Posttraumatic Stress Disorder and Obsessive-Compulsive Disorder do not seem to be directly related to innate defense reactions. Such evolutionary approach offers a reliable theoretical framework for the study of the biological determinants of anxiety disorders, and a sound basis for psychiatric classification.Os transtornos de ansiedade são classificados conforme a sintomatologia, decurso temporal e resposta terapêutica. Paralelamente, a análise experimental dos comportamentos de defesa identificou três estratégias comuns a diferentes espécies de animais, desencadeadas por situações de perigo predatório potencial, distal ou proximal, respectivamente. A primeira consiste na investigação cautelosa do ambiente, avaliando o risco. Supõe-se que a emoção que a acompanha seja a ansiedade e sua patologia, o Transtorno de Ansiedade Generalizada. A segunda é expressa pela fuga orientada ou pela inibição comportamental, sendo a emoção correlata o medo, e a patologia representada pelas Fobias Específicas. Finalmente, a

  8. 3D laptop for defense applications

    Science.gov (United States)

    Edmondson, Richard; Chenault, David

    2012-06-01

    Polaris Sensor Technologies has developed numerous 3D display systems using a US Army patented approach. These displays have been developed as prototypes for handheld controllers for robotic systems and closed hatch driving, and as part of a TALON robot upgrade for 3D vision, providing depth perception for the operator for improved manipulation and hazard avoidance. In this paper we discuss the prototype rugged 3D laptop computer and its applications to defense missions. The prototype 3D laptop combines full temporal and spatial resolution display with the rugged Amrel laptop computer. The display is viewed through protective passive polarized eyewear, and allows combined 2D and 3D content. Uses include robot tele-operation with live 3D video or synthetically rendered scenery, mission planning and rehearsal, enhanced 3D data interpretation, and simulation.

  9. Ballistic Missile Defense: New Plans, Old Challenges

    Directory of Open Access Journals (Sweden)

    Elizabeth Zolotukhina

    2010-01-01

    Full Text Available On September 17, 2009—the 70th anniversary of the Soviet invasion of Poland in 1939 that marked the beginning of World War II—the Obama Administration announced its intention to shelve plans for the U.S. Ballistic Missile Defense (BMD that had been developed under former President George W. Bush. Pointing to a new intelligence assessment, President Obama argued that his predecessor's plan to deploy an X-band radar station outside of Prague, Czech Republic, and 10 two-stage interceptor missiles in Poland would not adequately protect America and its European allies from the Iranian threat and reiterated his opposition to utilizing unproven technology in any European BMD architecture.

  10. Free radicals, antioxidant defense systems, and schizophrenia.

    Science.gov (United States)

    Wu, Jing Qin; Kosten, Thomas R; Zhang, Xiang Yang

    2013-10-01

    The etiopathogenic mechanisms of schizophrenia are to date unknown, although several hypotheses have been suggested. Accumulating evidence suggests that excessive free radical production or oxidative stress may be involved in the pathophysiology of schizophrenia as evidenced by increased production of reactive oxygen or decreased antioxidant protection in schizophrenic patients. This review aims to summarize the basic molecular mechanisms of free radical metabolism, the impaired antioxidant defense system and membrane pathology in schizophrenia, their interrelationships with the characteristic clinical symptoms and the implications for antipsychotic treatments. In schizophrenia, there is accumulating evidence of altered antioxidant enzyme activities and increased levels of lipid peroxidation, as well as altered levels of plasma antioxidants. Moreover, free radical-mediated abnormalities may contribute to specific aspects of schizophrenic symptomatology and complications of its treatment with antipsychotic drugs, as well as the development of tardive dyskinesia (TD). Finally, the potential therapeutic strategies implicated by the accumulating data on oxidative stress mechanisms for the treatment of schizophrenia are discussed.

  11. Climate Change Impacts at Department of Defense

    Energy Technology Data Exchange (ETDEWEB)

    Kotamarthi, Rao [Argonne National Lab. (ANL), Argonne, IL (United States); Wang, Jiali [Argonne National Lab. (ANL), Argonne, IL (United States); Zoebel, Zach [Univ. of Illinois, Urbana, IL (United States); Wuebbles, Don [Univ. of Illinois, Urbana, IL (United States); Hayhoe, Katharine [Texas Tech Univ., Lubbock, TX (United States); Stein, Michael [Univ. of Chicago, IL (United States); Changnon, David [Northern Illinois Univ., DeKalb, IL (United States)

    2017-06-16

    This project is aimed at providing the U.S. Department of Defense (DoD) with a comprehensive analysis of the uncertainty associated with generating climate projections at the regional scale that can be used by stakeholders and decision makers to quantify and plan for the impacts of future climate change at specific locations. The merits and limitations of commonly used downscaling models, ranging from simple to complex, are compared, and their appropriateness for application at installation scales is evaluated. Downscaled climate projections are generated at selected DoD installations using dynamic and statistical methods with an emphasis on generating probability distributions of climate variables and their associated uncertainties. The sites selection and selection of variables and parameters for downscaling was based on a comprehensive understanding of the current and projected roles that weather and climate play in operating, maintaining, and planning DoD facilities and installations.

  12. Defensive Diterpene from the Aeolidoidean Phyllodesmium longicirrum.

    Science.gov (United States)

    Bogdanov, Alexander; Hertzer, Cora; Kehraus, Stefan; Nietzer, Samuel; Rohde, Sven; Schupp, Peter J; Wägele, Heike; König, Gabriele M

    2016-03-25

    Phyllodesmium is a tropical marine slug genus with about 30 described species. None of them have a protective shell, and all of them feed on octocorals that are generally known to provide defensive compounds and thus help to defend the naked slugs against sympatric predators, such as fish, crabs, cephalopods, and echinoderms. Phyllodesmium longicirrum is the species that grows the biggest and that is least protected by camouflage on its respective food, usually a soft coral of the genus Sarcophyton. Investigation of the lipophilic extract of a single specimen of P. longicirrum from the Great Barrier Reef (Australia) led to the isolation of four new polycyclic diterpenes. Compound 1 showed significant deterrent activity in a fish feeding assay.

  13. Second Line of Defense Spares Program Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, Dale L.; Muller, George; Mercier, Theresa M.; Brigantic, Robert T.; Perkins, Casey J.; Cooley, Scott K.

    2012-11-20

    The Office of the Second Line of Defense (SLD) is part of the Department of Energy‘s (DOE) National Nuclear Security Administration (NNSA). The SLD Program accomplishes its critical global security mission by forming cooperative relationships with partner countries to install passive radiation detection systems that augment traditional inspection and law enforcement measures by alerting border officials to the presence of special nuclear or other radiological materials in cross-border traffic. An important tenet of the program is to work collaboratively with these countries to establish the necessary processes, procedures, infrastructure and conditions that will enable them to fully assume the financial and technical responsibilities for operating the equipment. As the number of operational deployments grows, the SLD Program faces an increasingly complex logistics process to promote the timely and efficient supply of spare parts.

  14. Computer network defense through radial wave functions

    Science.gov (United States)

    Malloy, Ian J.

    The purpose of this research is to synthesize basic and fundamental findings in quantum computing, as applied to the attack and defense of conventional computer networks. The concept focuses on uses of radio waves as a shield for, and attack against traditional computers. A logic bomb is analogous to a landmine in a computer network, and if one was to implement it as non-trivial mitigation, it will aid computer network defense. As has been seen in kinetic warfare, the use of landmines has been devastating to geopolitical regions in that they are severely difficult for a civilian to avoid triggering given the unknown position of a landmine. Thus, the importance of understanding a logic bomb is relevant and has corollaries to quantum mechanics as well. The research synthesizes quantum logic phase shifts in certain respects using the Dynamic Data Exchange protocol in software written for this work, as well as a C-NOT gate applied to a virtual quantum circuit environment by implementing a Quantum Fourier Transform. The research focus applies the principles of coherence and entanglement from quantum physics, the concept of expert systems in artificial intelligence, principles of prime number based cryptography with trapdoor functions, and modeling radio wave propagation against an event from unknown parameters. This comes as a program relying on the artificial intelligence concept of an expert system in conjunction with trigger events for a trapdoor function relying on infinite recursion, as well as system mechanics for elliptic curve cryptography along orbital angular momenta. Here trapdoor both denotes the form of cipher, as well as the implied relationship to logic bombs.

  15. Contaminants at Arctic formerly used defense sites

    Directory of Open Access Journals (Sweden)

    DO Carpenter

    2012-11-01

    Full Text Available This study was conducted in order to determine if the source of contaminants at formerly used defense sites (FUDS in Alaska were deposited as a result of military occupancy or from long-­-distance transport. This determination largely influences whether remediation will occur, and, if so, to what extent. For this reason, plant samples (rinsed and unrinsed and sediment cores were collected at military and remote sites on St. Lawrence Island (SLI and Norton Sound, Alaska during the summers of 2002, 2006, and 2007 and analyzed for persistent organic pollutants. On St. Lawrence Island sediment core samples were collected at the Northeast Cape FUDS, also a traditional fishing/hunting camp, and were sectioned and analyzed for concentrations of Polychlorinated biphenyl (PCB congeners, Mirex, Dichlorodiphenyldichloroethylene (DDE, Hexachlorobenzene (HCB, Mercury and Cesium-­-137 (137Cs. Differences in the total concentrations and distributions of PCB congeners, Mirex, DDE and Mercury in sediment cores and in plants collected from the two SLI and three Norton Sound mainland formerly used defense sites indicate the majority of the contaminants found can be temporally related to releases during military occupancy and subsequent redistribution of contaminants. Contaminants in plant samples at the SLI sites are elevated relative to the two remote sites located on St. Lawrence Island and the three mainland Norton Sound FUDS at Elim, Unalakleet, and Wales. The concentrations, lateral and vertical distribution of the total PCBs, and congener-­-specific differences in sediments and plants readily differentiate locally derived from globally transported contaminants. The relative contaminant concentrations in sediment cores and between rinsed and unrinsed plants collected from the NEC FUDS indicate contaminants were remobilized and redistributed during recent site remediation activities.

  16. Flexible resource allocation during plant defense responses

    Directory of Open Access Journals (Sweden)

    Jack C. Schultz

    2013-08-01

    Full Text Available Plants are organisms composed of modules connected by xylem and phloem transport streams. Attack by both insects and pathogens elicits sometimes rapid defense responses in the attacked module. We have also known for some time that proteins are often reallocated away from pathogen-infected tissues, while the same infection sites may draw carbohydrates to them. This has been interpreted as a tug of war in which the plant withdraws critical resources to block microbial growth while the microbes attempt to acquire more resources. Sink-source regulated transport among modules of critical resources, particularly carbon and nitrogen, is also altered in response to attack. Insects and jasmonate can increase local sink strength, drawing carbohydrates that support defense production. Shortly after attack, carbohydrates may also be drawn to the root. The rate and direction of movement of photosynthate or signals in phloem in response to attack is subject to constraints that include branching, degree of connection among tissues, distance between sources and sinks, proximity, strength, and number of competing sinks, and phloem loading/unloading regulators. Movement of materials (e.g., amino acids, signals to or from attack sites in xylem is less well understood but is partly driven by transpiration. The root is an influential sink and may regulate sink-source interactions and transport above and below ground as well as between the plant and the rhizosphere and nearby, connected plants. Research on resource translocation in response to pathogens or herbivores has focused on biochemical mechanisms; whole-plant research is needed to determine which, if any, of these plant behaviors actually influence plant fitness.

  17. Evaluating Moving Target Defense with PLADD

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Stephen T. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Outkin, Alexander V. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Gearhart, Jared Lee [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Hobbs, Jacob Aaron [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Siirola, John Daniel [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Phillips, Cynthia A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Verzi, Stephen Joseph [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Tauritz, Daniel [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Mulder, Samuel A. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Naugle, Asmeret Bier [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-09-15

    This project evaluates the effectiveness of moving target defense (MTD) techniques using a new game we have designed, called PLADD, inspired by the game FlipIt [28]. PLADD extends FlipIt by incorporating what we believe are key MTD concepts. We have analyzed PLADD and proven the existence of a defender strategy that pushes a rational attacker out of the game, demonstrated how limited the strategies available to an attacker are in PLADD, and derived analytic expressions for the expected utility of the game’s players in multiple game variants. We have created an algorithm for finding a defender’s optimal PLADD strategy. We show that in the special case of achieving deterrence in PLADD, MTD is not always cost effective and that its optimal deployment may shift abruptly from not using MTD at all to using it as aggressively as possible. We believe our effort provides basic, fundamental insights into the use of MTD, but conclude that a truly practical analysis requires model selection and calibration based on real scenarios and empirical data. We propose several avenues for further inquiry, including (1) agents with adaptive capabilities more reflective of real world adversaries, (2) the presence of multiple, heterogeneous adversaries, (3) computational game theory-based approaches such as coevolution to allow scaling to the real world beyond the limitations of analytical analysis and classical game theory, (4) mapping the game to real-world scenarios, (5) taking player risk into account when designing a strategy (in addition to expected payoff), (6) improving our understanding of the dynamic nature of MTD-inspired games by using a martingale representation, defensive forecasting, and techniques from signal processing, and (7) using adversarial games to develop inherently resilient cyber systems.

  18. Next Generation Nuclear Plant Defense-in-Depth Approach

    Energy Technology Data Exchange (ETDEWEB)

    Edward G. Wallace; Karl N. Fleming; Edward M. Burns

    2009-12-01

    The purpose of this paper is to (1) document the definition of defense-in-depth and the pproach that will be used to assure that its principles are satisfied for the NGNP project and (2) identify the specific questions proposed for preapplication discussions with the NRC. Defense-in-depth is a safety philosophy in which multiple lines of defense and conservative design and evaluation methods are applied to assure the safety of the public. The philosophy is also intended to deliver a design that is tolerant to uncertainties in knowledge of plant behavior, component reliability or operator performance that might compromise safety. This paper includes a review of the regulatory foundation for defense-in-depth, a definition of defense-in-depth that is appropriate for advanced reactor designs based on High Temperature Gas-cooled Reactor (HTGR) technology, and an explanation of how this safety philosophy is achieved in the NGNP.

  19. Transport of defense compounds from source to sink

    DEFF Research Database (Denmark)

    Jørgensen, Morten Egevang; Nour-Eldin, Hussam Hassan; Halkier, Barbara Ann

    2015-01-01

    Plants synthesize a plethora of defense compounds crucial for their survival in a challenging and changing environment. Transport processes are important for shaping the distribution pattern of defense compounds, albeit focus hitherto has been mostly on their biosynthetic pathways. A recent...... identification of two glucosinolate transporters represents a breakthrough in our understanding of glucosinolate transport in Arabidopsis and has advanced knowledge in transport of defense compounds. In this review, we discuss the role of the glucosinolate transporters in establishing dynamic glucosinolate...... distribution patterns and source-sink relations. We focus on lessons learned from glucosinolate transport that may apply to transport of other defense compounds and discuss future avenues in the emerging field of defense compound transport....

  20. Promoter-Based Integration in Plant Defense Regulation

    DEFF Research Database (Denmark)

    Li, Baohua; Gaudinier, Allison; Tang, Michelle

    2014-01-01

    A key unanswered question in plant biology is how a plant regulates metabolism to maximize performance across an array of biotic and abiotic environmental stresses. In this study, we addressed the potential breadth of transcriptional regulation that can alter accumulation of the defensive...... validation, we showed that >75% of tested transcription factor (TF) mutants significantly altered the accumulation of the defensive glucosinolates. These glucosinolate phenotypes were conditional upon the environment and tissue type, suggesting that these TFs may allow the plant to tune its defenses...... to the local environment. Furthermore, the pattern of TF/promoter interactions could partially explain mutant phenotypes. This work shows that defense chemistry within Arabidopsis has a highly intricate transcriptional regulatory system that may allow for the optimization of defense metabolite accumulation...