WorldWideScience

Sample records for acid liberation eicosanoid

  1. Eicosanoid-mediated immunity in insects

    Science.gov (United States)

    Eicosanoid is a collective term for oxygenated metabolites of C20 polyunsaturated fatty acids. As seen in mammals, eicosanoids play crucial roles in mediating various physiological processes, including immune responses, in insects. Upon microbial pathogen infection, non-self recognition signals are ...

  2. Combined effects of dietary polyunsaturated fatty acids and parasite exposure on eicosanoid-related gene expression in an invertebrate model.

    Science.gov (United States)

    Schlotz, Nina; Roulin, Anne; Ebert, Dieter; Martin-Creuzburg, Dominik

    2016-11-01

    Eicosanoids derive from essential polyunsaturated fatty acids (PUFA) and play crucial roles in immunity, development, and reproduction. However, potential links between dietary PUFA supply and eicosanoid biosynthesis are poorly understood, especially in invertebrates. Using Daphnia magna and its bacterial parasite Pasteuria ramosa as model system, we studied the expression of genes coding for key enzymes in eicosanoid biosynthesis and of genes related to oogenesis in response to dietary arachidonic acid and eicosapentaenoic acid in parasite-exposed and non-exposed animals. Gene expression related to cyclooxygenase activity was especially responsive to the dietary PUFA supply and parasite challenge, indicating a role for prostanoid eicosanoids in immunity and reproduction. Vitellogenin gene expression was induced upon parasite exposure in all food treatments, suggesting infection-related interference with the host's reproductive system. Our findings highlight the potential of dietary PUFA to modulate the expression of key enzymes involved in eicosanoid biosynthesis and reproduction and thus underpin the idea that the dietary PUFA supply can influence invertebrate immune functions and host-parasite interactions. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Ultraviolet B irradiation induces changes in the distribution and release of arachidonic acid, dihomo-gamma-linolenic acid, and eicosapentaenoic acid in human keratinocytes in culture

    International Nuclear Information System (INIS)

    Punnonen, K.; Puustinen, T.; Jansen, C.T.

    1987-01-01

    There is increasing evidence that derivatives of 20-carbon polyunsaturated fatty acids, the eicosanoids, play an important role in the inflammatory responses of the human skin. To better understand the metabolic fate of fatty acids in the skin, the effect of ultraviolet B (UVB) irradiation (280-320 nm) on the distribution and release of 14 C-labeled arachidonic acid, dihomo-gamma-linolenic acid, and eicosapentaenoic acid in human keratinocytes in culture was investigated. Ultraviolet B irradiation induced the release of all three 14 C-labeled fatty acids from the phospholipids, especially from phosphatidylethanolamine, and this was accompanied by increased labeling of the nonphosphorus lipids. This finding suggests that UVB induces a significant liberation of eicosanoid precursor fatty acids from cellular phospholipids, but the liberated fatty acids are largely reincorporated into the nonphosphorus lipids. In conclusion, the present study suggests that not only arachidonic acid but also dihomo-gamma-linolenic acid, and eicosapentaenoic acid might be involved in the UVB irradiation-induced inflammatory reactions of human skin

  4. Activation and Regulation of Cellular Eicosanoid Biosynthesis

    Directory of Open Access Journals (Sweden)

    Thomas G. Brock

    2007-01-01

    Full Text Available There is a growing appreciation for the wide variety of physiological responses that are regulated by lipid messengers. One particular group of lipid messengers, the eicosanoids, plays a central role in regulating immune and inflammatory responses in a receptor-mediated fashion. These mediators are related in that they are all derived from one polyunsaturated fatty acid, arachidonic acid. However, the various eicosanoids are synthesized by a wide variety of cell types by distinct enzymatic pathways, and have diverse roles in immunity and inflammation. In this review, the major pathways involved in the synthesis of eicosanoids, as well as key points of regulation, are presented.

  5. Highly sensitive and specific derivatization strategy to profile and quantitate eicosanoids by UPLC-MS/MS

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Ting; Tie, Cai; Wang, Zhe; Zhang, Jin-Lan, E-mail: zhjl@imm.ac.cn

    2017-01-15

    Eicosanoids are signaling molecules mainly oxidized from arachidonic acid (ARA) and eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). They have attracted increasing attention from the scientists attributing to their essential physiological functions. However, their quantification have long been challenged by the low abundance, high structure similarity, poor stability and limited ionization efficiency. In this paper, an ultra-high performance liquid chromatograph coupled with tandem mass spectrometry (UPLC-MS/MS) strategy was developed for the comprehensive profiling of more than 60 eicosanoids based on an efficient derivatization reagent 2,4-bis(diethylamino)-6-hydrazino-1,3,5-triazine (T3) and general multiple reaction monitoring (MRM) parameters. Carboxylic acid of eicosanoid was converted to amide in 30 min at 4 °C with derivatization yield larger than 99%. Limits of quantitation (LOQs) for derivatized eicosanoids varied from 0.05 to 50 pg depending on their structures. The sensitivities of derivatized eicosanoids were enhanced by 10- to 5000-folds compared to free eicosanoids. Stabilities of T3 modified eicosanoids were also highly improved compared to free eicosanoids. This new method can also be used to quantify eicosanoids in bio-samples using isotopic internal standards with high efficiency and reliability within 19 min. 46 and 50 eicosanoids in rat plasma and heart tissue from control and acute myocardial ischemia (AMI) model rats were respectively profiled and quantitated using this new method. And 24 of 46 and 25 of 50 eicosanoids were found to be significantly changed between control and model groups. The changed eicosanoids related to AMI modeling were further statistically analyzed and interpreted based on eicosanoid metabolism pathway. - Highlights: • Eicosanoids are important signaling molecules. • A highly sensitive and specific derivatization strategy was developed for eicosanoid profiling. • The strategy was employed for

  6. Highly sensitive and specific derivatization strategy to profile and quantitate eicosanoids by UPLC-MS/MS

    International Nuclear Information System (INIS)

    Hu, Ting; Tie, Cai; Wang, Zhe; Zhang, Jin-Lan

    2017-01-01

    Eicosanoids are signaling molecules mainly oxidized from arachidonic acid (ARA) and eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). They have attracted increasing attention from the scientists attributing to their essential physiological functions. However, their quantification have long been challenged by the low abundance, high structure similarity, poor stability and limited ionization efficiency. In this paper, an ultra-high performance liquid chromatograph coupled with tandem mass spectrometry (UPLC-MS/MS) strategy was developed for the comprehensive profiling of more than 60 eicosanoids based on an efficient derivatization reagent 2,4-bis(diethylamino)-6-hydrazino-1,3,5-triazine (T3) and general multiple reaction monitoring (MRM) parameters. Carboxylic acid of eicosanoid was converted to amide in 30 min at 4 °C with derivatization yield larger than 99%. Limits of quantitation (LOQs) for derivatized eicosanoids varied from 0.05 to 50 pg depending on their structures. The sensitivities of derivatized eicosanoids were enhanced by 10- to 5000-folds compared to free eicosanoids. Stabilities of T3 modified eicosanoids were also highly improved compared to free eicosanoids. This new method can also be used to quantify eicosanoids in bio-samples using isotopic internal standards with high efficiency and reliability within 19 min. 46 and 50 eicosanoids in rat plasma and heart tissue from control and acute myocardial ischemia (AMI) model rats were respectively profiled and quantitated using this new method. And 24 of 46 and 25 of 50 eicosanoids were found to be significantly changed between control and model groups. The changed eicosanoids related to AMI modeling were further statistically analyzed and interpreted based on eicosanoid metabolism pathway. - Highlights: • Eicosanoids are important signaling molecules. • A highly sensitive and specific derivatization strategy was developed for eicosanoid profiling. • The strategy was employed for

  7. Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity

    Directory of Open Access Journals (Sweden)

    Jennifer M. Monk

    2014-01-01

    Full Text Available During colitis, activation of two inflammatory T cell subsets, Th17 and Th1 cells, promotes ongoing intestinal inflammatory responses. n-6 polyunsaturated fatty acid- (PUFA- derived eicosanoids, such as prostaglandin E2 (PGE2, promote Th17 cell-mediated inflammation, while n-3 PUFA antagonize both Th17 and Th1 cells and suppress PGE2 levels. We utilized two genetic mouse models, which differentially antagonize PGE2 levels, to examine the effect on Th17 cells and disease outcomes in trinitrobenzene sulfonic acid- (TNBS- induced colitis. Fat-1 mice contain the ω3 desaturase gene from C. elegans and synthesize n-3 PUFA de novo, thereby reducing the biosynthesis of n-6 PUFA-derived eicosanoids. In contrast, Fads1 Null mice contain a disrupted Δ5 desaturase gene and produce lower levels of n-6 PUFA-derived eicosanoids. Compared to Wt littermates, Fat-1 and Fads1 Null mice exhibited a similar colitic phenotype characterized by reduced colonic mucosal inflammatory eicosanoid levels and mRNA expression of Th17 cell markers (IL-17A, RORγτ, and IL-23, decreased percentages of Th17 cells and, improved colon injury scores (P≤0.05. Thus, during colitis, similar outcomes were obtained in two genetically distinct models, both of which antagonize PGE2 levels via different mechanisms. Our data highlight the critical impact of n-6 PUFA-derived eicosanoids in the promotion of Th17 cell-mediated colonic inflammation.

  8. EICOSANOIDS AND INFLAMMATION

    Directory of Open Access Journals (Sweden)

    A. E. Karateev

    2016-01-01

    Full Text Available Inflammation is the most important element in the pathogenesis of major human diseases. It determines the fundamental value of anti-inflammatory therapy in the modern concept of targeted pathogenetic treatment. The rational choice of anti-inflammatory drugs and the design of new promising agents are inconceivable without clear knowledge of the characteristics of development of an inflammatory response. Eicosanoids, the metabolites of polyunsaturated fatty acids, play a key role in the process of inflammation. These substances have diverse and frequently antagonistic biological effects, which is determined by their chemical structure and specific features of receptors with which they interact. Some of them (prostaglandins, leukotrienes, auxins, and hepoxilins are potential mediators of inflammation and pain; others (lipoxins, epoxyeicosatrienoic acid derivatives, resolvins, protectins, maresins, and endocannabinoids have anti-inflammatory and cytoprotective activities, contributing to the resolution of the inflammatory response. This review describes considers the main classes of eicosanoids, their metabolism, effects, and clinical significance, as well as the possibilities of pharmacological interventions in their synthesis or interaction with receptors. 

  9. Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival

    Directory of Open Access Journals (Sweden)

    Sin Man Lam

    2017-08-01

    Full Text Available Mechanistic basis governing the extreme longevity and developmental quiescence of dauer juvenile, a “non-ageing” developmental variant of Caenorhabditis elegans, has remained largely obscure. Using a lipidomic approach comprising multiple reaction monitoring transitions specific to distinct fatty acyl moieties, we demonstrated that in comparison to other developmental stages, the membrane phospholipids of dauer larva contain a unique enrichment of polyunsaturated fatty acids (PUFAs. Esterified PUFAs in phospholipids exhibited temporal accumulation throughout the course of dauer endurance, followed by sharp reductions prior to termination of diapause. Reductions in esterified PUFAs were accompanied by concomitant increases in unbound PUFAs, as well as their corresponding downstream oxidized derivatives (i.e. eicosanoids. Global phospholipidomics has unveiled that PUFA sequestration in membrane phospholipids denotes an essential aspect of dauer dormancy, principally via suppression of eicosanoid production; and a failure to upkeep membrane lipid homeostasis is associated with termination of dauer endurance. Keywords: Dauer larva, Phospholipids, Polyunsaturated fatty acids, Eicosanoids, Lipidomics, Caenorhabditis elegans

  10. Characterization and modulation of canine mast cell derived eicosanoids

    Science.gov (United States)

    Lin, Tzu-Yin; London, Cheryl A.

    2013-01-01

    Mast cells play an important role in both innate and acquired immunity as well as several pathological conditions including allergy, arthritis and neoplasia. They influence these processes by producing a variety of mediators including cytokines, chemokines and eicosanoids. Very little is currently known about the spectrum of inflammatory mediators, particularly eicosanoids (prostaglandins and leukotrienes), produced by canine mast cells. This is important since modulating mast cell derived eicosanoids may help in the treatment of autoimmune and inflammatory disorders. The purpose of this study was to investigate the spectrum of eicosanoids produced by normal canine mast cells and to evaluate the effects of cytokines and non-steroidal anti-inflammatory mediators (NSAIDS) on eicosanoid production and release. Canine bone marrow derived cultured mast cells (cBMCMCs) expressed COX-1, COX-2, and 5-LOX and synthesized and released PGD2, PGE2, LTB4, and LTC4 following activation by a variety of stimuli. The selective COX-2 NSAIDs carprofen (Rimadyl®) and deracoxib (Deramaxx®) inhibited PGD2 and PGE2 production but only slightly inhibited LTB4 and LTC4. The mixed COX-1/COX-2 inhibitor piroxicam blocked PGD2 and PGE2 production, but upregulated LTC4 following treatment while tepoxilan (Zubrin®), a pan COX/LOX inhibitor, markedly reduced the production of all eicosanoids. The LOX inhibitor nordihydroguaiaretic acid (NDGA) prevented LTB4/LTC4 release and BMBMC degranulation. Pre-incubation of cBMCMCs with IL-4 and SCF sensitized these cells to degranulation in response to substance P. In conclusion, canine BMCMCs produce an array of eicosanoids similar to those produced by mast cells from other species. Tepoxilan appeared to be the most effective NSAID for blocking eicosanoid production and thus may be useful for modulating mast cell mediated responses in dogs. PMID:20036014

  11. GC-ECNICI-MS/MS of eicosanoids as pentafluorobenzyl-trimethylsilyl (TMS) derivatives: Evidence of CAD-induced intramolecular TMS ether-to-ester rearrangement using carboxy-18O-labelled eicosanoids and possible implications in quantitative analysis.

    Science.gov (United States)

    Tsikas, Dimitrios

    2017-03-15

    GC-MS and GC-MS/MS of pentafluorobenzyl (PFB) ester trimethylsilyl (TMS) ether (PFB-TMS) derivatives of hydroxylated long-chain fatty acids including arachidonic acid metabolites, the eicosanoids, in the electron-capture negative-ion chemical ionization (ECNICI) mode are the most sensitive and accurate approaches to quantify carboxyl groups-containing compounds in complex biological fluids such as plasma and urine. Under ECNICI conditions, PFB-TMS derivatives of eicosanoids ionize to form very few ions, with the carboxylates [M-PFB] - being typically the most intense. Less intense ions may be additionally formed by consecutive neutral loss (NL) of trimethylsilanol (TMSOH, 90Da) groups ([M-PFB-(TMSOH) n ] - ). By using [1,1- 18 O 2 ]- and [1,ω- 18 O 2 ]-eicosanoids, we studied ion processes following collisionally activated dissociation (CAD) of the precursor ions [M-PFB] - . We found that CAD resulted in formation of product ions due to NL of a TMS 18 OH (92Da) group in monocarboxylic and of a PFB 18 OH (200Da) group in dicarboxylic eicosanoids. TMS 18 OH NL implies an intra-molecular transfer of the TMS group from hydroxyl groups to their carboxylate anions [M-PFB] - . From a mechanistic point of view, this rearrangement may explain formation of unique product ions in GC-MS/MS of eicosanoids under ECNICI conditions. From the quantitative point of view, quantification by GC-MS/MS of product ions due to [M-PFB-(TMSOH) n ] - and [M-PFB-TMS 18 OH-(TMSOH) n-1 ] - would reveal incorrect data, if [1,1- 18 O 2 ]-eicosanoids are used as internal standards and if no correction for the 18 O-loss is performed. In 18 O-labelled dicarboxylic eicosanoids, such as the major urinary metabolite (MUM) of E prostaglandins, i.e., [1,ω- 18 O 2 ]-PGE-MUM), no TMS ester/TMS ether rearrangement was observed. Yet, 18 O-loss occurred upon CAD of [M-PFB] - due to NL of PFB 18 OH (200Da). In both cases the extent of 18 O-loss needs to be determined and considered for accurate quantification

  12. Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Fernando H. G. Tessaro

    2015-01-01

    Full Text Available The biosynthesis pathway of eicosanoids derived from arachidonic acid, such as prostaglandins and leukotrienes, relates to the pathophysiology of diabetes mellitus (DM. A better understanding of how lipid mediators modulate the inflammatory process may help recognize key factors underlying the progression of diabetes complications. Our review presents recent knowledge about eicosanoid synthesis and signaling in DM-related complications, and discusses eicosanoid-related target therapeutics.

  13. Cyclic-AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?

    Directory of Open Access Journals (Sweden)

    Mark J. Post

    1992-01-01

    Full Text Available In this study the question was addressed whether cAMP mediated drugs induce a differential reduction of branches of the arachidonic acid metabolism rather than a global reduction of eicosanoid synthesis. The isolated lungs of actively sensitized rats were employed to study prostaglandin and leukotriene release in the presence and absence of the cAMP mediated drugs theophylline, milrinone, sulmazole, isobutyl-methylxanthine and salbutamol. The release of eicosanoids as measured by RIA was predominantly basal and continuous, with a mild antigen induced stimulation only for TXB2 and the leukotrienes. All drugs reduced eicosanoid release globally. It is concluded that cAMP mediated drugs interfere with arachidonic acid metabolism at a site proximal to the branching into lipoxygenase and cyclo-oxygenase pathways.

  14. Adipocyte glucose transport regulation by eicosanoid precursors and inhibitors

    International Nuclear Information System (INIS)

    Lee, H.C.C.

    1987-01-01

    Glucose uptake and free fatty acid release by adipocytes are increased by catecholamines. The mechanism of the stimulatory action of catecholamines on glucose uptake may be via eicosanoid production from release fatty acids. Rats were fed iso-nutrient diets with high or low safflower oil. After one month, 5 rats per diet group were fed diets with aspirin or without aspirin for 2 days. Isolated adipocytes from epididymal fat pads were incubated at 37 0 C, gassed with 95% O 2 -5% CO 2 in KRB buffer with 3% bovine serum albumin and with or without eicosanoid modifiers; a stimulator (10 -5 M norepinephrine, N), or inhibitors (167 μl of antiserum to prostaglandin E (AntiE) per 1600 μl or 23mM Asp), or combinations of these. At 2-, 5-, and 10-min incubation, samples of incubation mixtures were taken to measure 2-deoxy glucose transport using 3 H-2-deoxy glucose, 14 C-inulin, and liquid scintillation counter

  15. Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

    OpenAIRE

    Williamson, Sheara; Varma, Deepti; Brown, Michael; Jansen, Susan

    2011-01-01

    Endothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged African Americans (AA). Signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone. The relationship between aerobic fitness and eicosanoid formation following exercise in middle-aged African American hypertensives is unknown. Purpose. To determine the relationship between aerobic capaci...

  16. Fish oil, but not soy bean or olive oil enriched infusion decreases histopathological severity of acute pancreatitis in rats without affecting eicosanoid synthesis.

    Science.gov (United States)

    Kilian, Maik; Heukamp, Ina; Gregor, Ja Ilja; Schimke, Ingolf; Kristiansen, Glen; Wenger, Frank Axel

    2011-12-01

    Different dietary fatty acids affect eicosanoid metabolism in different ways, thus influencing the pro- and anti-inflammatory balance of prostaglandins and leukotrienes. Therefore, we analyzed the impact of [n-3], [n-6], and [n-9] fatty acids on eicosanoid metabolism and histopathology in acute pancreatitis in rats. Seventy-five male Sprague-Dawley rats were randomized into five groups (n = 15). Group 1 underwent only laparotomy, while in groups, 2-5 pancreatitis was induced. Groups 1 and 2 were then given saline infusion, groups 3-5 received fat emulsion (group 3: rich in [n-6], group 4: rich in [n-9], group 5: rich in [n-3] fatty acids) for another 18 h. Infusion rich in [n-3] fatty acids significantly decreased histopathological severity of pancreatitis, compared to all other groups. There was no difference concerning the concentrations of prostaglandins and leukotrienes between all groups. Parenteral infusion rich in [n-3] fatty acids reduced histopathological severity of acute pancreatitis in rats without changing eicosanoid metabolism at the endpoint.

  17. Chromatographic analysis and purification of multiply tritium-labelled eicosanoids

    International Nuclear Information System (INIS)

    Shevchenko, V.P.; Nagaev, I.Yu.; Myasoedov, N.F.

    1988-01-01

    A comparative study of different chromatographic techniques (gas-liquid (GLC), thin-layer (TLC), liquid (LC), high-pressure liquid (HPLC) chromatography) is presented. They were applied to the analysis and preparative purification of tritium-labelled eicosanoids with a molar radioactivity of 1.8-8.8 TBq/mmol, obtained by selective hydrogenation and by chemical or enzymic methods. The possibility of analyzing reaction mixtures and isolating individual multiply labelled eicosanoids with a chemical and radiochemical purity of 95-98% was demonstrated. Special features of HPLC for high molar radioactivity eicosanoids are considered. (author) 9 refs.; 6 tabs

  18. Eicosanoids and Related Compounds in Plants and Animals (Edited by A. F. Rowley, H. Kuhn, and T. Schewe)

    Science.gov (United States)

    Minderhout, Reviewed By Vicky

    2000-04-01

    I was intrigued with the title Eicosanoids and Related Compounds in Plants and Animals because of my interest in eicosanoid biochemistry and the fact that most biochemistry texts cover the mammalian component (briefly) but include nothing on plants or other eukaryotic systems. How do eicosanoids function in plants? I wanted to know. The driving force for this book was the session specifically devoted to Non-Mammalian Eicosanoids at each of the 8th, 9th, and 10th International Conferences on Prostaglandins and Related Compounds. This collection probably represents one of the first attempts to gather a broad cross-section of the work in this field. The editors do not wish to repeat material available in key reviews elsewhere. Instead, they provide a useful bibliography, including books, review articles and important works for further reading. Each chapter incorporates an extensive list of references and the book includes a subject index. The editors, judging by the numbers of recent publications, are active researchers in this field. The book is divided into two sections. The first covers the enzymes and factors involved in the biosynthesis of eicosanoids. There is an introductory chapter on pathways, which includes both animal and plant systems. The next five chapters examine the diversity and evolutionary aspects of several proteins: cyclooxygenases; lipooxygenases, both mammalian and plant; and 5-lipooxygenase-activating-protein. This section concludes with a chapter covering the production of oxygenated fatty acid derivatives that are produced by or are active in fungi, as broadly defined. The second section of the book covers the functional aspects of eicosanoids and related compounds. Two chapters dealing with lipoxygenases in plants are followed by three chapters on eicosanoids in invertebrates, amphibians, and fish. The second section was of the most interest to me personally because I was able find answers to my initial question. How do these eicosanoids

  19. Irradiation of protoporphyric mice induces down-regulation of epidermal eicosanoid metabolism

    International Nuclear Information System (INIS)

    He, D.; Lim, H.W.

    1991-01-01

    This study investigated the effect of radiation on clinical and histologic changes, and on cutaneous eicosanoid metabolism, in Skh:HR-1 hairless albino mice rendered protoporphyric by the administration of collidine. At 0.1-18 h after exposure to 12 kJ/m2 of 396-406 nm irradiation, thicknesses of back skin and ears were measured, and histologic changes were evaluated by using hematoxylin and eosin (H-E) and Giemsa's stains. Activities of eicosanoid-metabolizing enzymes in epidermal and dermal homogenates were assessed by incubating the tissue homogenates with 3H-AA, followed by quantitation of the eicosanoids generated by radio-TLC. In irradiated protoporphyric mice, an increase of back-skin thickness was noted at 0.1 h, reaching a peak at 18 h, whereas maximal increase in ear thickness was observed at 12 h. Histologic changes included dermal edema, increased mast cell degranulation, and mononuclear cells in the dermis. In these irradiated protoporphyric animals, generations of 6 keto-PGF1a, PGF2a, PGE2, PGD2, and HETE by epidermal eicosanoid-metabolizing enzymes were markedly suppressed at all the timepoints studied. Dermal eicosanoid-metabolizing enzymes of irradiated protoporphyric mice generated increased amounts of PGE2 and HETE at 18 h, probably reflecting the presence of dermal cellular infiltrates. The suppression of the activities of epidermal eicosanoid-metabolizing enzymes was prevented by intraperitoneal injection of WR-2721, a sulfhydryl group generator, prior to irradiation, suggesting that the suppression was secondary to photo-oxidative damage of the enzymes during the in vivo phototoxic response. These results suggest that the effect of protoporphyrin and radiation on cutaneous eicosanoid metabolism in this animal model in vivo is that of a down regulation of the activities of epidermal eicosanoid-metabolizing enzymes

  20. Why eicosanoids could represent a new class of tocolytics on uterine activity in pregnant women.

    Science.gov (United States)

    Corriveau, Stéphanie; Berthiaume, Maryse; Rousseau, Eric; Pasquier, Jean-Charles

    2009-10-01

    The purpose of this study was to assess the effects of exogenous eicosanoids on spontaneous uterine contractile activity. Eight uterine biopsies were performed from women who were undergoing elective cesarean delivery. Tension measurements were performed in vitro on myometrial strips. Contractile activities were quantified by the calculation of the area under the curve. The effects of eicosanoids and specific enzyme inhibitors were assessed. Fractions from various uterine tissues were analyzed by Western blot. Data demonstrate the presence, in some tested tissues, of cytochrome P-450 epoxygenase and soluble epoxide hydrolase, which respectively produce and degrade epoxyeicosatrienoic acid regioisomers. Inhibition of soluble epoxide hydrolase with 12-(3-adamantan-1-yl-ureido)-dodecanoic acid or omega-hydroxylase with N-methylsulfonyl-12,12-dibromododec-11-enamide resulted in a tocolytic effect; N-methylsulfonyl-6-[2-propargyloxyphenyl] hexanamide, which is an epoxygenase inhibitor, had no effect. Exogenous epoxyeicosatrienoic acids displayed significant tocolytic effects on spontaneous contractile activities. Epoxy- and hydroxyeicosanoids represent new bioactive, arachidonic acid by-products with in vitro tocolytic activities. These findings suggest that cytochrome P-450 isozymes may represent relevant pharmacologic targets under physiopathologic conditions.

  1. UPLC-MS/MS-Based Profiling of Eicosanoids in RAW264.7 Cells Treated with Lipopolysaccharide

    Directory of Open Access Journals (Sweden)

    Jae Won Lee

    2016-04-01

    Full Text Available While both the pro- and anti-inflammatory effects of several eicosanoids have been widely studied, the degree of inflammation in cells that results from various eicosanoids has yet to be comprehensively studied. The objective of this study was to assess the effect of lipopolysaccharide (LPS treatment on eicosanoid content in RAW264.7 cells. An Ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS-based profiling method was used to analyze the eicosanoid contents of RAW264.7 cells treated with different LPS concentrations. The profiling data were subjected to statistical analyses, such as principal component analysis (PCA and hierarchical clustering analysis. LPS treatment increased nitric oxide production and secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6, in a concentration-dependent manner. In total, 79 eicosanoids were identified in the cells. RAW264.7 cells treated with different LPS concentrations were well differentiated in the PCA score plot. A heatmap was used to identify the eicosanoids that were up- or down-regulated according to the degree of inflammation and LPS concentration. Thirty-nine eicosanoids were upregulated and seven were down-regulated by LPS treatment in a concentration-dependent manner. Our novel UPLC-MS/MS technique can profile eicosanoids, and can evaluate the correlations between inflammation and eicosanoid metabolism.

  2. Urine Eicosanoids in the Metabolic Abnormalities, Telmisartan, and HIV Infection (MATH Trial.

    Directory of Open Access Journals (Sweden)

    Catherine N Le

    Full Text Available Arachidonic acid metabolites (eicosanoids reflect oxidative stress and vascular health and have been associated with anthropometric measures and sex differences in cross-sectional analyses of HIV-infected (HIV+ persons. Telmisartan is an angiotensin receptor blocker and PPAR-γ agonist with potential anti-inflammatory and metabolic benefits. We assessed telmisartan's effects on urine eicosanoids among HIV+ adults with central adiposity on suppressive antiretroviral therapy enrolled in a prospective clinical trial.Thirty-five HIV+ adults (15 women; 20 men completed 24 weeks of open-label oral telmisartan 40mg daily. Lumbar computed tomography quantified visceral (VAT and subcutaneous (SAT abdominal adipose tissue. Urine F2-isoprostane (F2-IsoP, prostaglandin E2 (PGE-M, prostacyclin (PGI-M, and thromboxane B2 (TxB-M were quantified at baseline and 24 weeks using gas/liquid chromatography-mass spectroscopy. Mann-Whitney-U tests compared sub-group differences; Spearman's rho assessed correlations between clinical factors and eicosanoid levels.Median PGE-M increased on telmisartan (p5% VAT (+3.7 ng/mg cr, p5% SAT (+1.7 ng/mg cr, p = 0.04. Median baseline F2-IsoP and TxB-M were slightly higher in women (both between-group p = 0.08 and did not change on telmisartan.Urine PGE-M increased with 24 weeks of telmisartan in virally suppressed, HIV+ adults with central adiposity. Associations with favorable fat redistribution suggest increased PGE-M may reflect a beneficial response.

  3. Impact of EPA ingestion on COX- and LOX-mediated eicosanoid synthesis in skin with and without a pro-inflammatory UVR challenge – Report of a randomised controlled study in humans

    Science.gov (United States)

    Pilkington, Suzanne M; Rhodes, Lesley E; Al-Aasswad, Naser M I; Massey, Karen A; Nicolaou, Anna

    2014-01-01

    Scope Eicosapentaenoic acid (EPA), abundant in oily fish, is reported to reduce skin inflammation and provide photoprotection, potential mechanisms include competition with arachidonic acid (AA) for metabolism by cyclooxygenases/lipoxygenases to less pro-inflammatory mediators. We thus examine impact of EPA intake on levels of AA, EPA and their resulting eicosanoids in human skin with or without ultraviolet radiation (UVR) challenge. Methods and results In a double-blind randomised controlled study, 79 females took 5 g EPA-rich or control lipid for 12 wk. Pre- and post-supplementation, red blood cell and skin polyunsaturated fatty acids were assessed by GC, and eicosanoids from unexposed and UVR-exposed skin by LC-MS/MS. Active supplementation increased red blood cell and dermal EPA versus control (both p skin (p skin; 12-hydroxyeicosatetraenoic acids:12-HEPE was lower in UVR-exposed skin (3:1 versus 11:1; p skin EPA:AA content, shifting eicosanoid synthesis towards less pro-inflammatory species, and promoting a regulatory milieu under basal conditions and in response to inflammatory insult. PMID:24311515

  4. Analysis and chromatographic purification of eicosanoids multiply labeled by tritium

    International Nuclear Information System (INIS)

    Shevchenko, V.P.; Nagaev, I.Yu.; Myasoedov, N.F.

    1989-01-01

    We show the possibility of analysis and chromatographic purification of eicosanoids triply labeled by tritium. The described methods allow us to isolate chromatographically pure products obtained by selective hydrogenatin, chemical, and enzyme methods, with radiochemical purity at least 95-97%. The following methods are used to analyze the reaction mixtures and to isolate the tritium-labeled eicosanoids: gas-liquid chromatography, high-efficiency liquid chromatography, and thin-layer chromatography on supports impregnated with silver nitrate

  5. Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS: A prospective, randomized, double-blind, parallel group study

    Directory of Open Access Journals (Sweden)

    Chacon Pilar

    2011-04-01

    Full Text Available Abstract Background The use of lipid emulsions has been associated with changes in lung function and gas exchange which may be mediated by biologically active metabolites derived from arachidonic acid. The type and quantity of the lipid emulsions used could modulate this response, which is mediated by the eicosanoids. This study investigates the use of omega-3 fatty acid-enriched lipid emulsions in ARDS patients and their effects on eicosanoid values. Methods Prospective, randomized, double-blind, parallel group study carried out at the Intensive Medicine Department of Vall d'Hebron University Hospital (Barcelona-Spain. We studied 16 consecutive patients with ARDS and intolerance to enteral nutrition (14 men; age: 58 ± 13 years; APACHE II score 17.8 ± 2.3; Lung Injury Score: 3.1 ± 0.5; baseline PaO2/FiO2 ratio: 149 ± 40. Patients were randomized into two groups: Group A (n = 8 received the study emulsion Lipoplus® 20%, B. Braun Medical (50% MCT, 40% LCT, 10% fish oil (FO; Group B (n = 8 received the control emulsion Intralipid® Fresenius Kabi (100% LCT. Lipid emulsions were administered for 12 h at a dose of 0.12 g/kg/h. We measured LTB4, TXB2, and 6-keto prostaglandin F1α values at baseline [immediately before the administration of the lipid emulsions (T-0], at the end of the administration (T-12 and 24 hours after the beginning of the infusion (T 24 in arterial and mixed venous blood samples. Results In group A (FO LTB4, TXB2, 6-keto prostaglandin F1α levels fell during omega-3 administration (T12. After discontinuation (T24, levels of inflammatory markers (both systemic and pulmonary behaved erratically. In group B (LCT all systemic and pulmonary mediators increased during lipid administration and returned to baseline levels after discontinuation, but the differences did not reach statistical significance. There was a clear interaction between the treatment in group A (fish oil and changes in LTB4 over time. Conclusions Infusion of

  6. The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases.

    Science.gov (United States)

    Rhodes, Lesley E; Gledhill, Karl; Masoodi, Mojgan; Haylett, Ann K; Brownrigg, Margaret; Thody, Anthony J; Tobin, Desmond J; Nicolaou, Anna

    2009-11-01

    Sunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV) B-induced hydrolysis of membrane phospholipids releases polyunsaturated fatty acids, and their subsequent metabolism by cyclooxygenases (COXs) and lipoxygenases (LOXs) may produce potent eicosanoid mediators modulating different stages of the inflammation. Our objective was to identify candidate eicosanoids formed during the sunburn reaction in relation to its clinical and histological course. We exposed skin of healthy humans (n=32) to UVB and, for 72 h, examined expression of proinflammatory and anti-inflammatory eicosanoids using LC/ESI-MS/MS, and examined immunohistochemical expression of COX-2, 12-LOX, 15-LOX, and leukocyte markers, while quantifying clinical erythema. We show that vasodilatory prostaglandins (PGs) PGE(2), PGF(2alpha), and PGE(3) accompany the erythema in the first 24-48 h, associated with increased COX-2 expression at 24 h. Novel, potent leukocyte chemoattractants 11-, 12-, and 8-monohydroxy-eicosatetraenoic acid (HETE) are elevated from 4 to 72 h, in association with peak dermal neutrophil influx at 24 h, and increased dermal CD3(+) lymphocytes and 12- and 15-LOX expression from 24 to 72 h. Anti-inflammatory metabolite 15-HETE shows later expression, peaking at 72 h. Sunburn is characterized by overlapping sequential profiles of increases in COX products followed by LOX products that may regulate subsequent events and ultimately its resolution.

  7. Effects of sulfur oxides on eicosanoids

    International Nuclear Information System (INIS)

    Chen, L.C.; Miller, P.D.; Amdur, M.O.

    1989-01-01

    Ultrafine metal oxides and SO2 react during coal combustion or smelting operations to form primary emissions coated with an acidic SOx layer. Ongoing work in this laboratory has examined the effects of sulfur oxides on pulmonary functions of guinea pigs. We have previously reported that 20 micrograms/m3 acidic sulfur oxide as a surface layer on ultrafine ZnO particles decreases lung volumes, decreases carbon monoxide diffusing capacity, and causes lung inflammation in guinea pigs after 4 daily 3-h exposures. It also produces bronchial hypersensitivity following a single 1-h exposure. The importance of this surface layer is demonstrated by our observation that 200 micrograms/m3 of sulfuric acid droplets of equivalent size are needed to produce the same degree of hypersensitivity. This study characterized the concentration-dependent effects of in vivo exposures to sulfur oxides on arachidonic acid metabolism in the guinea pig lung, and investigated the time course and the relation between eicosanoid composition and pulmonary functions. We focused specifically on four cyclooxygenase metabolites of arachidonic acid, that is, prostaglandins (PG) E1, F2 alpha, 6-keto prostaglandin F1 alpha, and thromboxane (Tx) B2, and two groups of sulfidopeptide leukotrienes (C4, D4, E4, and F4). Guinea pigs were exposed to ultrafine ZnO aerosol (count median diameter = 0.05 microns, sigma g = 1.80) with a layer of acidic sulfur oxide on the surface of the particles. Lung lavage was collected after exposures, and the levels of arachidonic acid metabolites were determined using radioimmunoassay (RIA). Concentration-dependent promotion of PGF2 alpha and concentration-dependent suppression of LtB4 were observed. The increased PGF2 alpha was associated with depressed vital capacity and diffusing capacity of the lungs measured in guinea pigs exposed to the same atmosphere described in a previous study

  8. The eicosanoid response to high dose UVR exposure of individuals prone and resistant to sunburn.

    Science.gov (United States)

    Nicolaou, Anna; Masoodi, Mojgan; Gledhill, Karl; Haylett, Ann Katarina; Thody, Anthony John; Tobin, Desmond John; Rhodes, Lesley Elizabeth

    2012-02-01

    High personal UVR doses can be gained during leisure activities, causing intense self-resolving inflammation (sunburn) of unprotected skin. UVR activates release of membrane fatty acids and upregulates their metabolism by cyclooxygenases (COX) and lipoxygenases (LOX) to different eicosanoids. While COX-derived prostaglandin (PG)E(2) is a potent mediator of sunburn vasodilatation, LOX-derived 15-hydroxyeicosatetraenoic acid (HETE) and its lipoxin metabolites may contribute to sunburn limitation. We explored the relationships between expression of these lipid mediators and the clinical and histological outcomes, comparing responses of individuals prone and more resistant to sunburn. An acute UVR exposure of 12 SED (standard erythema dose) was applied to buttock skin of 32 white Caucasians (n = 16 phototype I/II, n = 16 phototype III/IV), and over the subsequent 72 h assessments were made of skin erythema, immunohistochemical expression of leukocyte markers, COX-2, 12-LOX, 15-LOX and nitric oxide synthase (NOS), and eicosanoid levels by LC/ESI-MS/MS. Evidence of a significant inflammatory response was seen earlier in phototype I/II with regard to expression of erythema (4 h, p sunburn, having greater influence in those prone to sunburn than those more resistant, given the same high UVR exposure conditions. This journal is © The Royal Society of Chemistry and Owner Societies 2012

  9. Fish oil feeding attenuates neuroinflammatory gene expression without concomitant changes in brain eicosanoids and docosanoids in a mouse model of Alzheimer's disease.

    Science.gov (United States)

    Hopperton, Kathryn E; Trépanier, Marc-Olivier; James, Nicholas C E; Chouinard-Watkins, Raphaël; Bazinet, Richard P

    2018-03-01

    Neuroinflammation is a recognized hallmark of Alzheimer's disease, along with accumulation of amyloid-β plaques, neurofibrillary tangles and synaptic loss. n-3 polyunsaturated fatty acids (PUFA) and molecules derived from them, including eicosapentaenoic acid-derived eicosanoids and docosahexaenoic acid-derived docosanoids, are known to have both anti-inflammatory and pro-resolving properties, while human observational data links consumption of these fatty acids to a decreased risk of Alzheimer's disease. Few studies have examined the neuroinflammation-modulating effects of n-3 PUFA feeding in an Alzheimer's disease-related model, and none have investigated whether these effects are mediated by changes in brain eicosanoids and docosanoids. Here, we use both a fat-1 transgenic mouse and a fish oil feeding model to study the impact of increasing tissue n-3 PUFA on neuroinflammation and the production of pro-inflammatory and pro-resolving lipid mediators. Fat-1 mice, transgenic animals that can convert n-6 to n-3 PUFA, and their wildtype littermates were fed diets containing either fish oil (high n-3 PUFA) or safflower oil (negligible n-3 PUFA) from weaning to 12 weeks. Animals then underwent intracerebroventricular infusion of either amyloid-β 1-40 or a control peptide. Hippocampi were collected from non-surgery and surgery animals 10 days after infusion. Microarray was used to measure enrichment of inflammation-associated gene categories and expression of genes involved in the synthesis of lipid mediators. Results were validated by real-time PCR in a separate cohort of animals. Lipid mediators were measured via liquid chromatography tandem mass spectrometry. Fat-1 and wildtype mice fed fish oil had higher total hippocampal DHA than wildtype mice fed the safflower oil diet. The safflower-fed mice, but not the fat-1 or fish oil-fed mice, had significantly increased expression in gene ontology categories associated with inflammation in response to amyloid

  10. Inhibition of epoxy-eicosanoid degradation improves the tocolytic effects of indomethacin in the uterus from pregnant women.

    Science.gov (United States)

    Corriveau, Stéphanie; Berthiaume, Maryse; Rousseau, Eric; Pasquier, Jean-Charles

    2011-11-01

    The incidence of preterm birth is an increasing problem. Indomethacin, a non-specific cyclooxygenase inhibitor, has been largely used as tocolytic in the treatment of preterm labor. The aim of the present study was to assess a putative synergistic tocolytic effect between the inhibition of the production of prostanoids and stabilization of epoxides fatty acids, particularly arachidonate on spontaneous uterine contractile activity. The experimental work was performed on uterine biopsies from consenting women undergoing elective cesarean delivery at term. Isometric tension measurements were performed on fresh human myometrial strips. Contractile activities have been monitored upon individual and combined treatments of indomethacin, DDMS, an inhibitor of hydroxy-eicosanoids production and AUDA, an inhibitor of epoxy-eicosanoids degradation. Interestingly, a significant and consistent synergic effect was observed when indomethacin and AUDA were simultaneously added, raising the possibility of a combined clinical use of cyclooxygenase and sEH inhibitors in attempt to treat preterm labor. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. Eicosanoid Production following One Bout of Exercise in Middle-Aged African American Pre- and Stage 1 Hypertensives

    Directory of Open Access Journals (Sweden)

    Sheara Williamson

    2011-01-01

    Full Text Available Endothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged African Americans (AA. Signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone. The relationship between aerobic fitness and eicosanoid formation following exercise in middle-aged African American hypertensives is unknown. Purpose. To determine the relationship between aerobic capacity and eicosanoid formation after a bout of moderate-intensity exercise in middle-aged AA hypertensives. Methods. Ten sedentary hypertensive AA underwent 50 min of aerobic exercise at 65% VO2max. Urine was collected for 24 hr on two occasions, prior to testing and immediately following the bout of exercise. Urinary metabolites of prostacyclin (6-keto PGF1α and thromboxane (11-dTXB2 were measured during the day and night periods by high-performance liquid chromatography (HPLC. Results. 6-keto PGF1α levels significantly increased (=.04 following the bout of exercise compared to the control day. There was a significant relationship (=.49, <.05 between 6-keto PGF1α levels and VO2max during the exercise day. Conclusion. Based on this preliminary study, there appears to be a relationship between aerobic capacity and exercise-induced 6-keto PGF1α production in middle-aged hypertensive AAs. AAs with lower VO2max had lower 6-keto PGF1α formation.

  12. Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer.

    Science.gov (United States)

    Zick, Suzanna M; Turgeon, D Kim; Ren, Jianwei; Ruffin, Mack T; Wright, Benjamin D; Sen, Ananda; Djuric, Zora; Brenner, Dean E

    2015-09-01

    Colorectal cancer (CRC) remains a significant cause of mortality. Inhibitors of cyclooxygenase (COX) and thus prostaglandin E2, are promising CRC preventives, but have significant toxicities. Ginger has been shown to inhibit COX, to decrease the incidence and multiplicity of adenomas, and decrease PGE2 concentrations in subjects at normal risk for CRC. This study was conducted to determine the effects of 2.0 g/d of ginger given orally on the levels of PGE2, leukotriene B4 (LTB4), 13-hydroxy-octadecadienoic acids, and 5-, 12-, & 15-hydroxyeicosatetraenoic acid, in the colonic mucosa of subjects at increased risk for CRC. We randomized 20 subjects to 2.0 g/d ginger or placebo for 28 d. At baseline and Day 28, a flexible sigmoidoscopy was used to obtain colon biopsies. A liquid chromatography mass spectrometry method was used to determine eicosanoid levels in the biopsies, and levels were expressed per amount of protein or free arachidonic acid (AA). There was a significant decrease in AA between baseline and Day 28 (P = 0.05) and significant increase in LTB4 (P = 0.04) when normalized to protein, in subjects treated with ginger versus placebo. No other changes in eicosanoids were observed. There was no difference between the groups in total adverse events (AE; P = 0.06). Ginger lacks the ability to decrease eicosanoid levels in people at increased risk for CRC. Ginger did appear to be both tolerable and safe; and could have chemopreventive effects through other mechanisms. Further investigation should focus on other markers of CRC risk in those at increased CRC risk. © 2014 Wiley Periodicals, Inc.

  13. Ferromagnetic particles as a rapid and robust sample preparation for the absolute quantification of seven eicosanoids in human plasma by UHPLC-MS/MS.

    Science.gov (United States)

    Suhr, Anna Catharina; Bruegel, Mathias; Maier, Barbara; Holdt, Lesca Miriam; Kleinhempel, Alisa; Teupser, Daniel; Grimm, Stefanie H; Vogeser, Michael

    2016-06-01

    We used ferromagnetic particles as a novel technique to deproteinize plasma samples prior to quantitative UHPLC-MS/MS analysis of seven eicosanoids [thromboxane B2 (TXB2), prostaglandin E2 (PGE2), PGD2, 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, arachidonic acid (AA)]. A combination of ferromagnetic particle enhanced deproteination and subsequent on-line solid phase extraction (on-line SPE) realized quick and convenient semi-automated sample preparation-in contrast to widely used manual SPE techniques which are rather laborious and therefore impede the investigation of AA metabolism in larger patient cohorts. Method evaluation was performed according to a protocol based on the EMA guideline for bioanalytical method validation, modified for endogenous compounds. Calibrators were prepared in ethanol. The calibration curves were found to be linear in a range of 0.1-80ngmL(-1) (TXB2, PGE2, PGD2), 0.05-40ngmL(-1) (5-HETE, 11-HETE), 0.5-400ngmL(-1) (12-HETE) and 25-9800ngmL(-1) (AA). Regarding all analytes and all quality controls, the resulting precision data (inter-assay 2.6 %-15.5 %; intra-assay 2.5 %-15.1 %, expressed as variation coefficient) as well as the accuracy results (inter-assay 93.3 %-125 %; intra-assay 91.7 %-114 %) were adequate. Further experiments addressing matrix effect, recovery and robustness, yielded also very satisfying results. As a proof of principle, the newly developed LC-MS/MS assay was employed to determine the capacity of AA metabolite release after whole blood stimulation in healthy blood donors. For this purpose, whole blood specimens of 5 healthy blood donors were analyzed at baseline and after a lipopolysaccharide (LPS) induced blood cell activation. In several baseline samples some eicosanoids levels were below the Lower Limit of Quantification. However, in the stimulated samples all chosen eicosanoids (except PGD2) could be quantified. These results, in context with those obtained in validation, demonstrate the

  14. Acrolein stimulates eicosanoid release from bovine airway epithelial cells

    International Nuclear Information System (INIS)

    Doupnik, C.A.; Leikauf, G.D.

    1990-01-01

    Injury to the airway mucosa after exposure to environmental irritants is associated with pulmonary inflammation and bronchial hyperresponsiveness. To better understand the relationships between mediator release and airway epithelial cell injury during irritant exposures, we studied the effects of acrolein, a low-molecular-weight aldehyde found in cigarette smoke, on arachidonic acid metabolism in cultured bovine tracheal epithelial cells. Confluent airway epithelial cell monolayers, prelabeled with [3H]arachidonic acid, released significant levels of 3H activity when exposed (20 min) to 100 microM acrolein. [3H]arachidonic acid products were resolved using reverse-phase high-performance liquid chromatography. Under control conditions the released 3H activity coeluted predominantly with the cyclooxygenase product, prostaglandin (PG) E2. After exposure to acrolein, significant peaks in 3H activity coeluted with the lipoxygenase products 12-hydroxyeicosatetraenoic acid (HETE) and 15-HETE, as well as with PGE2, PGF2 alpha, and 6-keto-PGF1 alpha. Dose-response relationships for acrolein-induced release of immunoreactive PGF2 alpha and PGE2 from unlabeled epithelial monolayers demonstrated 30 microM acrolein as the threshold dose, with 100 microM acrolein inducing nearly a fivefold increase in both PGF2 alpha and PGE2. Cellular viability after exposure to 100 microM acrolein, determined by released lactate dehydrogenase activity, was not affected until exposure periods were greater than or equal to 2 h. These results implicate the airway epithelial cell as a possible source of eicosanoids after exposure to acrolein

  15. Incorporation and distribution of dihomo-gamma-linolenic acid, arachidonic acid, and eicosapentaenoic acid in cultured human keratinocytes

    International Nuclear Information System (INIS)

    Punnonen, K.; Puustinen, T.; Jansen, C.T.

    1986-01-01

    Human keratinocytes in culture were labelled with 14 C-dihomo-gamma-linolenic acid, 14 C-arachidonic acid or 14 C-eicosapentaenoic acid. All three eicosanoid precursor fatty acids were effectively incorporated into the cells. In phospholipids most of the radioactivity was recovered, in neutral lipids a substantial amount, and as free unesterified fatty acids only a minor amount. Most of the radioactivity was found in phosphatidylethanolamine which was also the major phospholipid as measured by phosphorous assay. The incorporation of dihomo-gamma-linolenic acid and arachidonic acid into lipid subfractions was essentially similar. Eicosapentaenoic acid was, however, much less effectively incorporated into phosphatidylinositol + phosphatidylserine and, correspondingly, more effectively into triacylglycerols as compared to the two other precursor fatty acids. Once incorporated, the distribution of all three precursor fatty acids was relatively stable, and only minor amounts of fatty acids were released into the culture medium during short term culture (two days). Our study demonstrates that eicosanoid precursor fatty acids are avidly taken up by human keratinocytes and esterified into membrane lipids. The clinical implication of this finding is that dietary manipulations might be employed to cause changes in the fatty acid composition of keratinocytes

  16. Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation

    Science.gov (United States)

    Kirkby, Nicholas S.; Reed, Daniel M.; Edin, Matthew L.; Rauzi, Francesca; Mataragka, Stefania; Vojnovic, Ivana; Bishop-Bailey, David; Milne, Ginger L.; Longhurst, Hilary; Zeldin, Darryl C.; Mitchell, Jane A.; Warner, Timothy D.

    2016-01-01

    Eicosanoids are important vascular regulators, but the phospholipase A2 (PLA2) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss-of-function mutation in group IVA cytosolic phospholipase A2 (cPLA2α). Chromatography/mass spectrometry was used to determine levels of a broad range of eicosanoids produced by isolated vascular cells, and in plasma and urine. Eicosanoid release data were paired with studies of cellular function. Absence of cPLA2α almost abolished eicosanoid synthesis in platelets (e.g., thromboxane A2, control 20.5 ± 1.4 ng/ml vs. patient 0.1 ng/ml) and leukocytes [e.g., prostaglandin E2 (PGE2), control 21.9 ± 7.4 ng/ml vs. patient 1.9 ng/ml], and this was associated with impaired platelet activation and enhanced inflammatory responses. cPLA2α-deficient endothelial cells showed reduced, but not absent, formation of prostaglandin I2 (prostacyclin; control 956 ± 422 pg/ml vs. patient 196 pg/ml) and were primed for inflammation. In the urine, prostaglandin metabolites were selectively influenced by cPLA2α deficiency. For example, prostacyclin metabolites were strongly reduced (18.4% of control) in patients lacking cPLA2α, whereas PGE2 metabolites (77.8% of control) were similar to healthy volunteer levels. These studies constitute a definitive account, demonstrating the fundamental role of cPLA2α to eicosanoid formation and cellular responses within the human circulation.—Kirkby, N. S., Reed, D. M., Edin, M. L., Rauzi, F., Mataragka, S., Vojnovic, I., Bishop-Bailey, D., Milne, G. L., Longhurst, H., Zeldin, D. C., Mitchell, J. A., Warner, T. D. Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation. PMID:26183771

  17. Pharmacological inhibition of eicosanoid synthesis and hyperalgesia in yeast-injected rat paws

    International Nuclear Information System (INIS)

    Opas, E.E.; Dallob, A.; Herold, E.; Luell, S.; Humes, J.L.

    1986-01-01

    Brewer's yeast caused an inflammation characterized by edema and hyperalgesia when injected into the hindpaw of a rat. These events were temporally distinct and each was associated with increases of specific arachidonic and oxygenation products. As determined by radioimmunoassay (RIA) on whole paw lipid extracts, the 5-lipoxygenase (5-LO) products, leukotrienes C 4 and D 4 and 5-hydroxyeicosatetraendic acid (5-HETE) were synthesized concurrently with the onset of edema (maximal at 15 minutes after yeast injection). The hyperalgesic phase of the inflammation (3-4 hr after yeast injection) was associated with increased tissue levels of the cyclooxygenase (CO) products, prostaglandin E 2 and thromboxane B 2 (TXB 2 ) as well as increases in levels of the 5-LO products, leukotriene B 4 (LTB 4 ) and 5-HETE. Pharmacological agents modulated the synthesis of eicosanoids and suppressed the hyperalgesic response

  18. Liberalism, Liberal Egalitarianism or Communitarianism?

    Directory of Open Access Journals (Sweden)

    Wagner Facundo Fantoni

    2015-12-01

    Full Text Available Three philosophies have different proposals and pathways in the ethical field of the study and the solution of problems relating to justice: liberalism, liberal egalitarianism and communitarianism. His representatives are called respectively liberal, liberal-egalitarian and communitarian. In this paper, we intend to evaluate each of these philosophical lines, presenting their strengths and weaknesses, and to demonstrate that liberalism must be rejected  at  the  expense  of  liberal  egalitarianism  and  of  communitarianism.  These philosophies have more plausible ways of problem solving than the liberal way. Accordingly, the liberal egalitarianism and communitarianism not necessarily repel. On the contrary, they can be applied jointly, which will be demonstrated in this paper. This hypothesis is developed and confirmed in this paper through the survey and study of the relevant doctrine.

  19. Expression of eicosanoid biosynthetic and catabolic enzymes in peritoneal endometriosis.

    Science.gov (United States)

    Lousse, J-C; Defrère, S; Colette, S; Van Langendonckt, A; Donnez, J

    2010-03-01

    Increased peritoneal eicosanoid concentrations have been reported in endometriosis patients and might be important in disease-associated pain and inflammation. Here, we evaluated the expression of key biosynthetic and catabolic enzymes involved in this abnormal eicosanoid production in peritoneal macrophages and endometriotic lesions. Peritoneal macrophages, endometriotic lesions and matched eutopic endometrium were collected from endometriosis patients (n = 40). Peritoneal macrophages and eutopic endometrium samples were also collected from disease-free women (n = 25). Expression of type IIA secretory phospholipase A(2) (sPLA(2)-IIA), cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1), 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and 5-lipoxygenase (5-LO) was quantified by real-time PCR, and these five key enzymes were localized by immunohistochemistry. sPLA(2)-IIA, COX-2 and mPGES-1 mRNA was significantly increased in peritoneal macrophages of endometriosis patients compared with controls (P = 0.006, P = 0.016 and P = 0.025, respectively). In endometriosis patients, sPLA(2)-IIA, mPGES-1 and 15-PGDH mRNA was significantly enhanced in peritoneal lesions compared with matched eutopic endometrium (P endometriosis group compared with controls (P = 0.023). Finally, sPLA(2)-IIA, COX-2, mPGES-1 and 15-PGDH immunostaining was found mainly in endometrial glands, whereas 5-LO was distributed throughout the glands and stroma. Our study highlights an imbalance between eicosanoid biosynthesis and degradation in endometriosis patients. Both peritoneal macrophages and endometriotic lesions may be involved. Research into new molecules inhibiting biosynthetic enzymes (such as sPLA(2)-IIA and mPGES-1) and/or activating catabolic enzymes (such as 15-PGDH) may prove to be a major field of investigation in the development of targeted medical therapies.

  20. Liberation of Desmosine and Isodesmosine as Amino Acids from Insoluble Elastin by Elastolytic Proteases

    Science.gov (United States)

    Umeda, Hideyuki; Aikawa, Masanori; Libby, Peter

    2011-01-01

    The development of atherosclerotic lesions and abdominal aortic aneurysms involves degradation and loss of extracellular matrix components, such as collagen and elastin. Releases of the elastin cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in cardiovascular diseases. This study investigated the production of soluble elastin cross-linking structures by proteinases implicated in arterial diseases. Recombinant MMP-12 and neutrophil elastase liberated DES and IDE as amino acids from insoluble elastin. DES and IDE were also released from insoluble elastin exposed to monocyte/macrophage cell lines or human primary macrophages derived from peripheral blood monocytes. Elastin oxidized by reactive oxygen species (ROS) liberated more unconjugated DES and IDE than did non-oxidized elastin when incubated with MMP-12 or neutrophil elastase. These results support the exploration of free DES and IDE as biomarkers of elastin degradation. PMID:21726534

  1. Effect of primrose oil and corn oil diets on eicosanoid synthesis by rat mammary tumor induced by dimethylbenzanthracene (DMBA)

    Energy Technology Data Exchange (ETDEWEB)

    El-Ela, S.H.A.; Bunce, O.R.

    1986-03-01

    Evening primrose oil (PO) contains 9% gamma-linolenic acid (GLA) and 75% linoleic acid (LA) each of which are prostaglandin precursors. Corn oil (CO) contains 60% linoleic acid. Fifty day old virgin female rats were given DMBA (5 mg, intragastric). Three weeks post DMBA the rats were separated into two dietary groups of 20% PO and 20% CO, respectively. At 16 weeks post DMBA the rats were killed and mammary tumors analyzed by RIA for PGE/sub 1/, PGE/sub 2/, and 6-keto F/sub 1..cap alpha... PGE/sub 1/ levels in PO fed animals were increased two fold over those fed CO indicating that it is possible to shunt GLA toward monoenoic eicosanoid synthesis. However PGE/sub 2/ and 6 keto F/sub 1..cap alpha../ levels were 5x higher in PO compared to CO. Although this could be attributed to higher cis linoleic acid content of PO, more subtle mechanisms may be responsible.

  2. Time Dependent Production of Cytokines and Eicosanoids by Human Monocytic Leukaemia U937 Cells; Effects of Glucocorticosteroids

    Directory of Open Access Journals (Sweden)

    Ingrid M. Garrelds

    1999-01-01

    Full Text Available In the present study the human monoblast cell line U937 has been used as a model to study the function of human mononuclear phagocytes in asthma. The kinetics of the production of eicosanoids and cytokines, which are thought to play a role in the pathogenesis of asthma, were studied. In addition, the effects of glucocorticosteroids were investigated, as these drugs are of great importance for the treatment of asthmatic patients. After stimulation with phorbol-12 myristate acetate (PMA for 24h, U937 cells were cultured in the absence or presence of lipopolysaccharide (LPS: 1 and 5 μg ml-1 and glucocorticosteroids (budesonide, fluticasone propionate and prednisolone: 10-11, 10-9 and 10-7 M for 96h. The production of interleukin- 1β (IL-1β, interleukin-6 (IL-6, prostaglandin E2 (PGE2 and thromboxane B2 (TxB2 gradually increased in time after stimulation with LPS, whereas the transient production of tumor necrosis factor alpha (TNF-α reached its maximum between 6 and 12 h. Interferon-gamma (IFN-γ, interleukin-10 (IL-10 and leukotriene B4 (LTB4 were not detectable. All three glucocorticosteroids (budesonide, fluticasone propionate and prednisolone completely inhibited the production of both eicosanoids and cytokines. The production of eicosanoids was more sensitive to these glucocorticoids than the production of cytokines. The observed differences in the kinetics of the production of eicosanoids and cytokines stress the importance of time course experiments in studies on the effect of drugs on mononuclear cells.

  3. Interleukin-8 and eicosanoid production in the lung during moderate to severe Pneumocystis carinii pneumonia in AIDS: a role of interleukin-8 in the pathogenesis of P. carinii pneumonia

    DEFF Research Database (Denmark)

    Benfield, T L; van Steenwijk, R; Nielsen, T L

    1995-01-01

    (PG) and leukotrienes (LT)] are pro-inflammatory mediators released from arachidonic acid by action of phospholipase A2 (PLA2) and have been implicated in the host response to micro-organisms. Bronchoalveolar lavage (BAL) was performed on patients with PCP as part of a randomized study of adjuvant...... of IL-8 as a mediator in the pathogenesis of PCP, whereas the role of eicosanoids seems less clear....

  4. Liberalism

    OpenAIRE

    Pabst, Adrian

    2013-01-01

    Until the global economic crisis struck in 2008, liberalism was the dominant ideology of our time and undoubtedly the most influential political philosophy of the last 300 years or so. Its origins, evolution and meaning are deeply contested by liberal and non-liberal thinkers alike. Many contemporary historians and political philosophers claim that liberal thought first emerged in the late sixteenth or early seventeenth century and evolved into a distinct philosophical tradition during the Ag...

  5. Investigation of iodine liberation process in redox titration of potassium iodate with sodium thiosulfate

    International Nuclear Information System (INIS)

    Asakai, Toshiaki; Hioki, Akiharu

    2011-01-01

    Potassium iodate is often used as a reference material to standardize a sodium thiosulfate solution which is a familiar titrant for redox titrations. In the standardization, iodine (triiodide) liberated by potassium iodate in an acidic potassium iodide solution is titrated with a sodium thiosulfate solution. The iodine liberation process is significantly affected by the amount of acid, that of potassium iodide added, the waiting time for the liberation, and light; therefore, the process plays a key role for the accuracy of the titration results. Constant-voltage biamperometry with a modified dual platinum-chip electrode was utilized to monitor the amount of liberated iodine under several liberation conditions. Coulometric titration was utilized to determine the concentration of a sodium thiosulfate solution on an absolute basis. Potassium iodate was assayed by gravimetric titration with the sodium thiosulfate solution under several iodine liberation conditions. The liberation process was discussed from the changes in the apparent assay of potassium iodate. The information of the appropriate titration procedure obtained in the present study is useful for any analysts utilizing potassium iodate to standardize a thiosulfate solution.

  6. Investigation of iodine liberation process in redox titration of potassium iodate with sodium thiosulfate

    Energy Technology Data Exchange (ETDEWEB)

    Asakai, Toshiaki, E-mail: t-asakai@aist.go.jp [National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 3-9, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8563 (Japan); Hioki, Akiharu [National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 3-9, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8563 (Japan)

    2011-03-09

    Potassium iodate is often used as a reference material to standardize a sodium thiosulfate solution which is a familiar titrant for redox titrations. In the standardization, iodine (triiodide) liberated by potassium iodate in an acidic potassium iodide solution is titrated with a sodium thiosulfate solution. The iodine liberation process is significantly affected by the amount of acid, that of potassium iodide added, the waiting time for the liberation, and light; therefore, the process plays a key role for the accuracy of the titration results. Constant-voltage biamperometry with a modified dual platinum-chip electrode was utilized to monitor the amount of liberated iodine under several liberation conditions. Coulometric titration was utilized to determine the concentration of a sodium thiosulfate solution on an absolute basis. Potassium iodate was assayed by gravimetric titration with the sodium thiosulfate solution under several iodine liberation conditions. The liberation process was discussed from the changes in the apparent assay of potassium iodate. The information of the appropriate titration procedure obtained in the present study is useful for any analysts utilizing potassium iodate to standardize a thiosulfate solution.

  7. Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis

    DEFF Research Database (Denmark)

    Hillingsø, J.G.; Kjeldsen, J.; Schmidt, P.T.

    2002-01-01

    reflexes, we have studied the local effects of a single rectal dose of ropivacaine gel on rectal concentrations of eicosanoids and neurotransmittors in patients with relapsing ulcerative colitis.Methods: In a randomized, double-blind, placebo-con trolled study, concentrations of leukotriene B-4...... rectal administration of a 200-mg dose of ropivacaine- or placebo-gel by use of radioimmunoassays. For comparison with normal conditions, concentrations of neuropeptides were measured in another 19 patients with relapsing ulcerative colitis and 14 controls with non-inflamed colon.Results: No significant...... changes in concentrations of eicosanoids or neuropeptides were observed after ropivacaine or placebo administration. Baseline concentrations of all neuropeptides, except somatostatin, were significantly lower in active ulcerative colitis than in controls with non-inflamed colon.Conclusions: These findings...

  8. Arachidonic acid-mediated inhibition of a potassium current in the giant neurons of Aplysia

    International Nuclear Information System (INIS)

    Carlson, R.O.

    1990-01-01

    Biochemical and electrophysiological approaches were used to investigate the role of arachidonic acid (AA) in the modulation of an inwardly rectifying potassium current (I R ) in the giant neurons of the marine snail, Aplysia californica. Using [ 3 H]AA as tracer, the intracellular free AA pool in Aplysia ganglia was found to be in a state of constant and rapid turnover through deacylation and reacylation of phospholipid, primarily phosphatidyl-inositol. This constant turnover was accompanied by a constant release of free AA and eicosanoids into the extracellular medium. The effects of three pharmacological agents were characterized with regard to AA metabolism in Aplysia ganglia. 4-O-tetra-decanoylphorbol 13-acetate (TPA), an activator of protein kinase C, stimulated liberation of AA from phospholipid, and 4-bromophenacylbromide (BPB), an inhibitor of phospholipate A 2 , inhibited this liberation. Indomethacin at 250 μM was found to inhibit uptake of AA, likely through inhibition of acyl-CoA synthetase. These agents were also found to modulate I R in ways which were consistent with their biological effects: TPA inhibited I R , and both BPB and indomethacin stimulated I R . Modulation of I R by these substances was found not to involve cAMP metabolism. Acute application of exogenous AA did not affect I R ; however, I R in giant neurons was found to be inhibited after dialysis with AA or other unsaturated fatty acids. Also, after perfusion with BSA overnight, a treatment which strips the giant neurons of AA in lipid storage, I R was found to have increased over 2-fold. This perfusion-induced increase was inhibited by the presence of AA or by pretreatment of the giant neurons with BPB. These results suggest AA, provided through constant turnover from phospholipid, mediates constitutive inhibition of I R

  9. Liberal power Europe

    NARCIS (Netherlands)

    Wagner, W.M.

    2017-01-01

    The European Union is best understood as a liberal power – as an actor that is composed of liberal democracies whose interests, identities and institutions motivate and constrain its policy. The conceptualization of the EU as a liberal power helps to overcome three shortcomings of alternative

  10. Liberal Values at a Time of Neo-Liberalism

    Science.gov (United States)

    Evans, Mary

    2014-01-01

    Critical responses to changes in UK higher education have emerged from various quarters. This article suggests that some of these responses are collusive with neo-liberalism and that a greater attention might be paid to the possibilities of the word "liberal" and to the more democratic implications of certain US initiatives.

  11. Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids.

    Science.gov (United States)

    Das, Undurti N

    2013-10-01

    Autism has a strong genetic and environmental basis in which inflammatory markers and factors concerned with synapse formation, nerve transmission, and information processing such as brain-derived neurotrophic factor (BDNF), polyunsaturated fatty acids (PUFAs): arachidonic (AA), eicosapentaenoic (EPA), and docosahexaenoic acids (DHA) and their products and neurotransmitters: dopamine, serotonin, acetylcholine, γ-aminobutyric acid, and catecholamines and cytokines are altered. Antioxidants, vitamins, minerals, and trace elements are needed for the normal metabolism of neurotrophic factors, eicosanoids, and neurotransmitters, supporting reports of their alterations in autism. But, the exact relationship among these factors and their interaction with genes and proteins concerned with brain development and growth is not clear. It is suggested that maternal infections and inflammation and adverse events during intrauterine growth of the fetus could lead to alterations in the gene expression profile and proteomics that results in dysfunction of the neuronal function and neurotransmitters, alteration(s) in the metabolism of PUFAs and their metabolites resulting in excess production of proinflammatory eicosanoids and cytokines and a deficiency of anti-inflammatory cytokines and bioactive lipids that ultimately results in the development of autism. Based on these evidences, it is proposed that selective delivery of BDNF and methods designed to augment the production of anti-inflammatory cytokines and eicosanoids and PUFAs may prevent, arrest, or reverse the autism disease process. Copyright © 2013 Elsevier Inc. All rights reserved.

  12. Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids

    Directory of Open Access Journals (Sweden)

    P.C. Calder

    1998-04-01

    Full Text Available 1. Fish oils are rich in the long-chain n-3 polyunsaturated fatty acids (PUFAs, eicosapentaenoic (20:5n-3 and docosahexaenoic (22:6n-3 acids. Linseed oil and green plant tissues are rich in the precursor fatty acid, a-linolenic acid (18:3n-3. Most vegetable oils are rich in the n-6 PUFA linoleic acid (18:2n-6, the precursor of arachidonic acid (20:4n-6. 2. Arachidonic acid-derived eicosanoids such as prostaglandin E2 are pro-inflammatory and regulate the functions of cells of the immune system. Consumption of fish oils leads to replacement of arachidonic acid in cell membranes by eicosapentaenoic acid. This changes the amount and alters the balance of eicosanoids produced. 3. Consumption of fish oils diminishes lymphocyte proliferation, T-cell-mediated cytotoxicity, natural killer cell activity, macrophage-mediated cytotoxicity, monocyte and neutrophil chemotaxis, major histocompatibility class II expression and antigen presentation, production of pro-inflammatory cytokines (interleukins 1 and 6, tumour necrosis factor and adhesion molecule expression. 4. Feeding laboratory animals fish oil reduces acute and chronic inflammatory responses, improves survival to endotoxin and in models of autoimmunity and prolongs the survival of grafted organs. 5. Feeding fish oil reduces cell-mediated immune responses. 6. Fish oil supplementation may be clinically useful in acute and chronic inflammatory conditions and following transplantation. 7. n-3 PUFAs may exert their effects by modulating signal transduction and/or gene expression within inflammatory and immune cells.

  13. Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms

    Directory of Open Access Journals (Sweden)

    Dayanne da Silva Borges Betiati

    2013-01-01

    Full Text Available The development of leukemia and lymphomas is related to the increase in inflammatory process modulators. These, in turn, have divergent actions on the neoplastic process. Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity. Simultaneously, the inflammatory process promotes the mobilization of fatty acids from the cell membrane to produce lipid mediators, which also participate of the inflammatory response. Eicosapentaenoic (EPA and docosahexaenoic (DHA omega-3 fatty acids, when incorporated in the plasmatic membrane, decrease the arachidonic acid (AA metabolism and the production of eicosanoids derived from it. Thus, an alternative family of lipid mediators are produced that are often less inflammatory than those produced from arachidonic acid. Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation. Due to these properties, the objective of this literature review was to investigate studies published over the last 15 years on the effects of using omega-3 fatty acids on inflammatory markers in leukemia and lymphomas.

  14. Hong Kong Liberals Are WEIRD: Analytic Thought Increases Support for Liberal Policies.

    Science.gov (United States)

    Talhelm, Thomas

    2018-05-01

    This study tests whether liberals and conservatives within the same society think as if they were from different cultures. I tested this by measuring the cultural thought style of social liberals and conservatives in Hong Kong (Study 1). Liberals tended to think more analytically (more "WEIRD"), and conservatives tended to think more holistically (more common in East Asia). In Study 2, I trained people to think analytically or holistically before they read articles on political issues. Analytic thought caused people to form more liberal opinions, and holistic thought caused people to form more conservative opinions. The thought training affected participants' responses to a social issue, but not an economic issue or whether they identified as liberal or conservative. This study replicates a previous U.S. finding in an East Asian culture and a different political environment, suggesting that the link between politics and thought style extends beyond the United States.

  15. Liberal nationalism on immigration

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2009-01-01

    Liberal nationalists such as David Miller and Will Kymlicka have claimed that liberal principles have implausible implications with regard to the issue of immigration. They hold that nationality should play a normative role in this regard, and that this is necessary in order to justify restrictions...... on immigration. The present chapter discusses the envisaged role for considerations of nationality with regard to admission and residence, and examines the actual implications of arguments advanced by liberal nationalists as to why nationality should play this role. It is argued that the connection between...... nationality and immigration on liberal nationalist premises is not as straightforward as one might expect, and that the addition of considerations of nationality to liberal principles makes no practical difference with regard to reasons for restricting immigration or criteria of selection among applicants...

  16. THEORETICAL ASPECTS OF FINANCIAL LIBERALIZATION PROCESS

    Directory of Open Access Journals (Sweden)

    Ciupac-Ulici Maria-Lenuta

    2013-07-01

    Full Text Available Financial liberalization process and its implications on financial emerging markets have been multidisciplinary research since 1970. Reform of financial liberalization is a complex and long phenomena. This implies that the impact of this reform on financial markets should not be immediate, but rather gradually during a long time period. It is also important to note that liberalization does not occur in the same way on all financial markets. Each country, according to his specification regarding the economic climate and the specificity of financial markets, has differently set its progress of liberalization process. It is generally accepted that the process of financial liberalization is not composed of a single event, but a series of events. The idea is that market reform is a gradual process where the data identified above only refers to the most significant events. Regarding the effect of liberalization reform on emerging markets has been shown; on the one hand, that liberalization helps to reduce the cost of capital, helps to integrate the emerging markets in the global market, enhances economic growth and allows emerging markets to become more mature. On the other hand, financial liberalization process has a very ambiguous and inconclusive impact on informational efficiency and volatility in emerging markets. Launching liberalization reforms provided an analytical framework for studies that attempt to investigate the effectiveness of emerging markets and empirical links between liberalization and efficiency. The first reason is that with liberalization, the authors believe that emerging markets have become more speculative and more competitive. So there is a chance to see if the weak form market efficiency is verified. The second reason is that the authors explore the relationship between liberalization and efficiency. Researchers and regulators seek an answer to the fundamental question: financial liberalization helps the stock market

  17. Maternal dietary n-6 polyunsaturated fatty acid deprivation does not exacerbate post-weaning reductions in arachidonic acid and its mediators in the mouse hippocampus.

    Science.gov (United States)

    Alashmali, Shoug M; Kitson, Alex P; Lin, Lin; Lacombe, R J Scott; Bazinet, Richard P

    2017-09-13

    The present study examines how lowering maternal dietary n-6 polyunsaturated fatty acids (PUFA) (starting from pregnancy) compared to offspring (starting from post-weaning) affect the levels of n-6 and n-3 fatty acids in phospholipids (PL) and lipid mediators in the hippocampus of mice. Pregnant mice were randomly assigned to consume either a deprived or an adequate n-6 PUFA diet during pregnancy and lactation (maternal exposure). On postnatal day (PND) 21, half of the male pups were weaned onto the same diet as their dams, and the other half were switched to the other diet for 9 weeks (offspring exposure). At PND 84, upon head-focused high-energy microwave irradiation, hippocampi were collected for PL fatty acid and lipid mediator analyses. Arachidonic acid (ARA) concentrations were significantly decreased in both total PL and PL fractions, while eicosapentaenoic acid (EPA) concentrations were increased only in PL fractions upon n-6 PUFA deprivation of offspring, regardless of maternal exposure. Several ARA-derived eicosanoids were reduced, while some of the EPA-derived eicosanoids were elevated by n-6 PUFA deprivation in offspring. There was no effect of diet on docosahexaenoic acid (DHA) or DHA-derived docosanoids concentrations under either maternal or offspring exposure. These results indicate that the maternal exposure to dietary n-6 PUFA may not be as important as the offspring exposure in regulating hippocampal ARA and some lipid mediators. Results from this study will be helpful in the design of experiments aimed at testing the significance of altering brain ARA levels over different stages of life.

  18. Liberalization of local public services and modalities of local action in the liberalized sectors

    Directory of Open Access Journals (Sweden)

    Joaquin Tornos Mas

    2017-09-01

    Full Text Available In recent years we have witnessed a process of increasing liberalization of public services, which means returning economic activities that had been excluded from the market. This process has been less at the local level, but there have also been cases of liberalization of local public services, such as funeral services. This paper examines these liberalization processes and their consequences, analyzing what powers municipalities can exercise in relation to liberalized services, which, despite their return to the market, remain services of general interest.

  19. Does trade liberalization effect energy consumption?

    International Nuclear Information System (INIS)

    Ghani, Gairuzazmi M.

    2012-01-01

    The effect of trade liberalization on the environment can be directly linked to energy consumption, because energy consumption and production are the underlying cause of most pollutants that harm the environment. The descriptive statistics show that average annual growth of energy consumption per capita after trade liberalization varies among countries; hence it is a possibility that the effect of trade liberalization is conditional on factors other than liberalization per se. The regression results show that trade liberalization per se does not affect the growth of energy consumption of the developing countries analyzed, but its interaction with capital per labor reduces the growth of energy consumption as capital per labor increases. However, the effect is only significant after a certain minimum threshold level capital per labor is reached. On the other hand, economic growth increases energy consumption and its effect is not conditioned on trade liberalization. These two different effects mean that, with regards to energy consumption, countries at a higher level of economic development are more likely to reap the benefit of liberalization relative to less developed countries. - Research highlights: ► This paper examines the effect of trade liberalization on energy consumption. ► Developed countries are more likely to reap the benefit of trade liberalization. ► Growth of energy consumption after trade liberalization varies among countries. ► Interaction of capital per labor with liberalization reduces energy consumption.

  20. Effects of short- and long-term feeding of L-carnitine and congeners on the production of eicosanoids from rat peritoneal leucocytes

    NARCIS (Netherlands)

    I.M. Garrelds (Ingrid); G.R. Elliott (G.); F.J. Zijlstra (Freek); I.L. Bonta

    1994-01-01

    textabstractThe effect of short- and long-term feeding with L-carnitine, L-acetyl carnitine and L-propionyl carnitine on the production of eicosanoids front in vitro stimulated carrageenan-induced rat peritoneal macrophages was investigated. Both young (4 weeks) and old (18 months) rats were used. A

  1. Liberating Moral Reflection

    Science.gov (United States)

    Horell, Harold D.

    2013-01-01

    The author argues that if we are to foster life-giving and liberating moral reflection, we must first liberate moral reflection from distortions; specifically, from the distorting effects of moral insensitivity, destructive moral relativism, and confusions resulting from a failure to understand the dynamics of moral reflection. The author proposes…

  2. Postmodern liberalism

    Directory of Open Access Journals (Sweden)

    Kuljanin Branimir

    2013-01-01

    Full Text Available Modern liberalism is fundamentally different from the classical to the extent to which the post(countermodern is different from the modern. A shift occurred in the late sixties, at the time of the student movement and the 'Prague Spring'. In the late eighties and early nineties, they promised a life in freedom and entry into the 'European Home', into the 'family of European peoples'. Socialist countries of the Eastern Europe entered the era of 'transition', peaceful movement towards capitalism. Yesterday's Marxists and communists became liberals over night. Nowadays, when the whole world is in a deep crisis, including the lauded West, it is high time to consider where we are going and where we are. What is modern liberalism, an ideology governing the minds in our region for more than twenty years, is an issue we will discuss in this paper.

  3. Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems - an observational cohort study

    OpenAIRE

    Huss, Michael; V?lp, Andreas; Stauss-Grabo, Manuela

    2010-01-01

    Abstract Background Polyunsaturated fatty acids are essential nutrients for humans. They are structural and functional components of cell membranes and pre-stages of the hormonally and immunologically active eicosanoids. Recent discoveries have shown that the long-chained omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) also play an important role in the central nervous system. They are essential for normal brain functioning including attention and other neuropsy...

  4. Political liberalism and religious claims

    Science.gov (United States)

    2016-01-01

    This article gives an overview of 4 important lacunae in political liberalism and identifies, in a preliminary fashion, some trends in the literature that can come in for support in filling these blind spots, which prevent political liberalism from a correct assessment of the diverse nature of religious claims. Political liberalism operates with implicit assumptions about religious actors being either ‘liberal’ or ‘fundamentalist’ and ignores a third, in-between group, namely traditionalist religious actors and their claims. After having explained what makes traditionalist religious actors different from liberal and fundamentalist religious actors, the author develops 4 areas in which political liberalism should be pushed further theoretically in order to correctly theorize the challenge which traditional religious actors pose to liberal democracy. These 4 areas (blind spots) are: (1) the context of translation; (2) the politics of exemptions; (3) the multivocality of theology; and (4) the transnational nature of norm-contestation. PMID:28344375

  5. Liberalism, Liberalization and Their Impacts of Muslim Education (Special Case of Indonesian Intellectuals

    Directory of Open Access Journals (Sweden)

    Hamid Fahmy Zarkasyi

    2012-05-01

    Full Text Available This paper is aimed at elucidating the liberalization of Muslim world and its impact on education. For  that  purpose  the  author  traces  at  the  outset  the  origin  and  the  basic  concept  of liberalism, which  is of  postmodern Western worldview, including  the concept of  religious liberalism. The impact of  liberalism in general is as wider as the meaning of  liberalism in Western sense of the words. However,  this paper  confines only on  the study of  their  impact  on Muslim education with special emphasis on national education policy and on religious thought which in turn would affect curriculum development. Liberalization of religious thought appears, inter alia, through the introduction  of  the  doctrine  of  relativity  of  truth,  religious  pluralism,  gender  equality  and deconstruction  of  shari’ah  and  the  likes. All  those  religious  discourse  conceptually  hinder  the development of  curriculum and  the teaching strategy of  moral  inculcation  to the students.

  6. Omega-3 fatty acids and inflammatory processes: from molecules to man.

    Science.gov (United States)

    Calder, Philip C

    2017-10-15

    Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspects of omega-6 (n-6) and omega-3 (n-3) fatty acids and explain the roles of bioactive members of those fatty acid families in inflammatory processes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 fatty acids found in oily fish and fish oil supplements. These fatty acids are capable of partly inhibiting many aspects of inflammation including leucocyte chemotaxis, adhesion molecule expression and leucocyte-endothelial adhesive interactions, production of eicosanoids like prostaglandins and leukotrienes from the n-6 fatty acid arachidonic acid and production of pro-inflammatory cytokines. In addition, EPA gives rise to eicosanoids that often have lower biological potency than those produced from arachidonic acid, and EPA and DHA give rise to anti-inflammatory and inflammation resolving mediators called resolvins, protectins and maresins. Mechanisms underlying the anti-inflammatory actions of EPA and DHA include altered cell membrane phospholipid fatty acid composition, disruption of lipid rafts, inhibition of activation of the pro-inflammatory transcription factor nuclear factor κB so reducing expression of inflammatory genes and activation of the anti-inflammatory transcription factor peroxisome proliferator-activated receptor γ. Animal experiments demonstrate benefit from EPA and DHA in a range of models of inflammatory conditions. Human trials demonstrate benefit of oral n-3 fatty acids in rheumatoid arthritis and in stabilizing advanced atherosclerotic plaques. Intravenous n-3 fatty acids may have benefits in critically ill patients through reduced inflammation. The anti-inflammatory and inflammation resolving actions of EPA, DHA and their derivatives are of clinical relevance. © 2017 The Author

  7. The liberal illusion of uniqueness.

    Science.gov (United States)

    Stern, Chadly; West, Tessa V; Schmitt, Peter G

    2014-01-01

    In two studies, we demonstrated that liberals underestimate their similarity to other liberals (i.e., display truly false uniqueness), whereas moderates and conservatives overestimate their similarity to other moderates and conservatives (i.e., display truly false consensus; Studies 1 and 2). We further demonstrated that a fundamental difference between liberals and conservatives in the motivation to feel unique explains this ideological distinction in the accuracy of estimating similarity (Study 2). Implications of the accuracy of consensus estimates for mobilizing liberal and conservative political movements are discussed.

  8. Do Liberal Arts Colleges Make Students More Liberal? Some Initial Evidence

    Science.gov (United States)

    Hanson, Jana M.; Weeden, Dustin D.; Pascarella, Ernest T.; Blaich, Charles

    2012-01-01

    The effect of attending college on students' political ideology has been a controversial topic for many decades. In this study, we explored the relationship between attending a liberal arts college and students' political views. Compared to their counterparts at other 4-year institutions, liberal arts college students began postsecondary education…

  9. Hobbes, Liberalism, and Political Education.

    Science.gov (United States)

    Esquith, Stephen L.

    The connection between liberal political philosophy and political education is discussed with particular emphasis on the philosophy of Thomas Hobbes. The purpose of the essay is to explain how liberal citizens become committed to a distinctively liberal conception of the common good. Part 1 discusses Hobbes' theory that rationally determining…

  10. The Philosophical Worth of Liberal Peacebuilding

    Directory of Open Access Journals (Sweden)

    Muhammad Waffaa Kharisma

    2017-05-01

    Full Text Available The concept of Liberal Peacebuilding is often associated with the failure of pushing liberalisation in war-torn failed states: the practice of liberal peacebuilding as a liberal project instead of a peacebuilding effort. The essay starts with breaking down the basic premises of a liberal peacebuilding and its ideological drive. Then, it identifies and evaluates the critics and alternatives to liberal peacebuilding. The essay sees that the implementation of fixed standard peacebuilding packages in vastly different scenarios and countries is the consequence of practicing liberal peacebuilding as a liberal project. This essay argues that liberal peacebuilding is worth saving if it recognises itself as an unfinished project, and instead advocates peacebuilding efforts that are more concentrated as a (and in showing technical solution rather than an ideological impulse. As such, the essay proposes the prioritisation of maintaining stability in a post-conflict state, through concentrating on ensuring the specific case-per-case technical solutions, often which is attributed to institutional foundation to ensure the deliveries of collective aims and interests of local society.

  11. Liberal intolerance in European education debates

    DEFF Research Database (Denmark)

    Olsen, Tore Vincents

    2017-01-01

    The reaction against non-western immigrants and especially Muslims has been analysed both in terms of an exclusionary civic nationalism and in terms of an assertive liberalism. Similar to exclusionary civic nationalism, assertive liberalism purports to defend liberal democratic principles...... by subdividing it into four categories of liberal intolerance and demonstrates this by analysing six national debates on the accommodation of cultural and religious diversity in education. The analysis indicates that the nature of liberal intolerance understood as the combination of the four categories...

  12. Liberal theory of passive citizenship

    Directory of Open Access Journals (Sweden)

    Salatić Stevan

    2013-01-01

    Full Text Available In this seminar paper I will focus on the analysis of liberal theory of citizenship. The focus of the study will be on the liberal-communitarian dispute in the theory of citizenship, with main ideas of the most important representatives of liberal discourse in the field of citizenship also being discussed. I will look more closely at the ideas of T.H. Marshall, as the most significant writer of liberal orthodoxy in the second half of the twentieth century, his contribution to liberal theory of passive citizenship, but I will also deal with the ideas of his biggest critics, both from the aspect of liberalism and from the aspect of communitarianism, including Anthony Giddens, Claus Offe, Michael Mann, Barrington Moore and Brian Turner. The emphasis will be on Marshall's term 'conquest of citizenship', as well as on the derivation of various theories of state from the obtained rights achieved through the expansion of the concept of citizenship. Finally, I will say something about modern obstacles to theories of passive citizenship derived from the communitarian school.

  13. Effect of short- and long-term feeding of L-carnitine and its congeners on the production of eicosanoids from rat peritoneal leukocytes

    NARCIS (Netherlands)

    Garrelds, I.M.; Elliott, G.R.; Zijlstra, F.; Bonta, I.

    1994-01-01

    The effect of short- and long-term feeding with L-carnitine, L-acetyl carnitine and L-propionyl carnitine on the production of eicosanoids from in vitro stimulated carrageenan-induced rat peritoneal macrophages was investigated. Both young (4 weeks) and old (18 months) rats were used. A lower number

  14. Revisiting Liberal Democratic Universalism: A Critical Rhetoric of the Liberal Democratic World Order

    Directory of Open Access Journals (Sweden)

    Rose Joy E. Smith

    2016-12-01

    Full Text Available Liberal democracy has become the predominant political regime in the 21st century even in countries that have little or no history of ‘democratic structures and practices’. However, it seems as though setting up a functional, stable, and viable democratic state is harder than overthrowing autocratic rulers. This rhetorical criticism explores gridlocks that hamper the development of universal liberal democratic values by emphasizing the Western hegemonic status of defining what liberal democracy is. It is pertinent to look into this dominant role considering that it is through these values that actions, policies, and other values are to be construed and judged. This paper aims to (1 highlight the role of moral cosmopolitanism as the initial step of Western hegemony, (2 identify the paradox of defining liberal democracy as universal but treating it as a particular, and (3 discuss the ironies of democratic imperialism and its hindrance to self-determination. This paper hopes to shed some light in the importance of various interpretations, definitions, and adaptations of liberal democratic values depending on the context of the society incorporating, its culture, its values, and its identity, in order to find a more comprehensive definition of democracy.

  15. Para além da paz liberal? respostas ao "retrocesso" Beyond liberal peace? responses to "backsliding"

    Directory of Open Access Journals (Sweden)

    Oliver P Richmond

    2010-12-01

    Full Text Available A ortodoxia familiar de construção da paz liberal depende da transplantação e da exportação de condicionalidade e dependência, com vistas a consolidar um contrato social entre populações, seus governos e o Estado, em que repouse uma paz liberal legítima e consensual. O que, com frequência, ocorre, é uma forma híbrida de paz liberal, sujeita a críticas locais poderosas, à resistência, por vezes, e à percepção de que a construção da paz internacional está fracassando em corresponder às expectativas. Em termos kantianos, os problemas com que a paz liberal tem se deparado e a crise pela qual está hoje passando podem ser denominados "retrocesso". Tem sido particularmente notável que a construção da paz liberal não vem sendo capaz de construir políticas unidas a partir de fragmentos territoriais no Kosovo, na Bósnia, no Afeganistão, no Iraque, no Sri Lanka e mesmo na Irlanda do Norte, onde alguns ou todos de seus elementos estão em desenvolvimento. Isso indica uma necessidade ou de reforma do modelo liberal para a paz, ou de estabelecimento de uma capacidade de coexistência desse modelo com alternativas, ou de substituição do modelo. Este artigo examina uma gama de questões inerentes ao paradigma de construção da paz liberal, algumas causas de "retrocesso" e o que pode ser feito no que tange a tais causas, no sentido de utilizar a construção da paz para criar um novo contrato social e atingir o que se poderia muito bem ser uma forma "híbrida liberal-local" de paz.The familiar orthodoxy of liberal peacebuilding depends upon transplanting and exporting conditionality and dependency in order to cement a social contract between populations, their governments and the state, on which rests a legitimate and consensual liberal peace. What often emerges is a hybrid form of the liberal peace, subject to powerful local critiques, sometimes resistance, and to the perception that international peacebuilding is failing to

  16. Liberal Internationalism: Theory, History, Practice

    Directory of Open Access Journals (Sweden)

    Oliver Stuenkel

    2014-01-01

    Full Text Available While liberalism keeps adapting to circumstances, its underlying dynamic is the same: Liberalism, Jahn, argues, is a political project that aims to establish individual freedom through private property and to protect and extend this freedom through government by consent - yet, it pursues this goal through the privatization and expropriation of common property and hence requires the production and reproduction of unequal power relations domestically and internationally. Liberalism is thus, in essence, made viable through power politics, with the mere difference that is uses liberal rhetoric as a fig leaf to conceal the ultimate goal: To provide a justification for American hegemony.

  17. Essays on financial liberalization

    NARCIS (Netherlands)

    Bumann, Silke

    2015-01-01

    This thesis investigates the effect of financial liberalization on economic growth, income inequality and financial instability. Chapter 1 describes aim and scope of the thesis. Chapter 2 provides a meta-analysis of the literature on financial liberalization and economic growth. It is found that

  18. Ethical Liberalism, Education and the "New Right."

    Science.gov (United States)

    Olssen, Mark

    2000-01-01

    Examines the philosophical tradition of ethical liberalism from its emergence as a coherent response to 19th century classical liberal individualism through contemporary formulations. Pursues origins in John Stuart Mills's writings and assesses ethical liberalism's relevance for understanding current neo-liberal policy restructuring in education.…

  19. Liberalism and Public Health Ethics.

    Science.gov (United States)

    Rajczi, Alex

    2016-02-01

    Many public health dilemmas involve a tension between the promotion of health and the rights of individuals. This article suggests that we should resolve the tension using our familiar liberal principles of government. The article considers the common objections that (i) liberalism is incompatible with standard public health interventions such as anti-smoking measures or intervention in food markets; (2) there are special reasons for hard paternalism in public health; and (3) liberalism is incompatible with proper protection of the community good. The article argues that we should examine these critiques in a larger methodological framework by first acknowledging that the right theory of public health ethics is the one we arrive at in reflective equilibrium. Once we examine the arguments for and against liberalism in that light, we can see the weaknesses in the objections and the strength of the case for liberalism in public health. © 2015 John Wiley & Sons Ltd.

  20. Effects of carnitine and its congeners on eicosanoid discharge from rat cells: implications for release of TNFα

    Directory of Open Access Journals (Sweden)

    Ingrid M. Garrelds

    1993-01-01

    Full Text Available THE acyl carrier coenzyme A (CoA is involved in fatty acid metabolism. The carnitine/CoA ratio is of particular importance in regulating the transport of long-chain fatty acids into mitochondria for oxidation. Also CoA has a role in the formation and breakdown of products from both the cyclooxygenase and lipoxygenase pathways of the precursor arachidonic acid. In the present study the effect of 4 days feeding of 300 mg/kg/day of L-carnitine, acetyl Lcarnitine and propionyl L-carnitine on the basal and calcium ionophore (A23187 stimulated release of arachidonic acid metabolites from rat carrageenin elicited peritoneal cells was investigated. There were two series of experiments carried out. In the first, the harvested peritoneal cell population consisted of less than 90% macrophages and additional polymorphonuclear (PMN leucocytes. The basal release of prostaglandin E2 (PGE2, 6-ketoprostaglandin F1α (6-keto-PGF1α and leukotriene B4 (LTB4 was stimulated by all treatments. The A23187 stimulated release of 6-keto-PGF1α and LTB4 was increased by all three compounds. The 6-keto-PGF1α:TxB2 and 6-keto-PGF1α:LTB4 ratios were increased by carnitine treatment. These results suggested that carnitine could modify the macrophage component of an inflammatory site in vivo. In the second series of experiments the harvested cell population was highly purified (>95% macrophages and none of the compounds fed to the rats caused a change of either eicosanoid or TNFα formation. Moreover the 6-keto-PGF1α:TxB2 and 6-keto-PGF1α:LTB4 ratios were not enhanced by any of the compounds tested. It is conceivable that in the first series the increased ratios 6-keto-PGF1α:TxB2 and 6-keto-PGF1α:LTB4 reflected the effect of carnitine or its congeners on PMN leucocytes rather than on macrophages.

  1. The "L-Word": A Short History of Liberalism.

    Science.gov (United States)

    Ball, Terence; Dagger, Richard

    1990-01-01

    Maintains that, in order to understand the current debate over liberalism, a historical perspective on the subject is necessary. Traces the history of liberalism from its inception in the Reformation to the present conflict between neoclassical liberalism and welfare liberalism. Focuses on the major theorists of liberalism. (RW)

  2. ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.

    Science.gov (United States)

    Wang, Weicang; Yang, Jun; Nimiya, Yoshiki; Lee, Kin Sing Stephen; Sanidad, Katherine; Qi, Weipeng; Sukamtoh, Elvira; Park, Yeonhwa; Liu, Zhenhua; Zhang, Guodong

    2017-10-01

    Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer; however, the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the role of eicosanoid signaling in the anti-colorectal cancer effects of ω-3 PUFAs. Our results showed that dietary feeding of ω-3 PUFAs-rich diets suppressed growth of MC38 colorectal tumor, and modulated profiles of fatty acids and eicosanoid metabolites in C57BL/6 mice. Notably, we found that dietary feeding of ω-3 PUFAs significantly increased levels of epoxydocosapentaenoic acids (EDPs, metabolites of ω-3 PUFA produced by cytochrome P450 enzymes) in plasma and tumor tissue of the treated mice. We further showed that systematic treatment with EDPs (dose=0.5 mg/kg per day) suppressed MC38 tumor growth in mice, with reduced expressions of pro-oncogenic genes such as C-myc, Axin2, and C-jun in tumor tissues. Together, these results support that formation of EDPs might contribute to the anti-colorectal cancer effects of ω-3 PUFAs. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Financial Liberalization and Financial Fragility

    OpenAIRE

    Enrica Detragiache; Asli Demirgüç-Kunt

    1998-01-01

    The authors study the empirical relationship between banking crises and financial liberalization using a panel of data for 53 countries for 1980-95. They find that banking crises are more likely to occur in liberalized financial systems. But financial liberalization's impact on a fragile banking sector is weaker where the institutional environment is strong--especially where there is respect for the rule of law, a low level of corruption, and good contract enforcement. They examine evidence o...

  4. Liberal Education and Citizenship.

    Science.gov (United States)

    Esquith, Stephen L.

    1991-01-01

    Discusses theories of liberal education as based on meritocratic and aristocratic assumptions. Describes liberal education as a social equalizer that at the some time hopes to produce an educated elite for expert policymaking. Stresses conflict between these assumptions. Argues that citizens should see public good as their own good and not see…

  5. Computer Science and the Liberal Arts

    Science.gov (United States)

    Shannon, Christine

    2010-01-01

    Computer science and the liberal arts have much to offer each other. Yet liberal arts colleges, in particular, have been slow to recognize the opportunity that the study of computer science provides for achieving the goals of a liberal education. After the precipitous drop in computer science enrollments during the first decade of this century,…

  6. Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients

    Directory of Open Access Journals (Sweden)

    Calder P.C.

    2003-01-01

    Full Text Available Lipids used in nutritional support of surgical or critically ill patients have been based on soybean oil, which is rich in the n-6 fatty acid linoleic acid (18:2n-6. Linoleic acid is the precursor of arachidonic acid (20:4n-6. In turn, arachidonic acid in cell membrane phospholipids is the substrate for the synthesis of a range of biologically active compounds (eicosanoids including prostaglandins, thromboxanes, and leukotrienes. These compounds can act as mediators in their own right and can also act as regulators of other processes, such as platelet aggregation, blood clotting, smooth muscle contraction, leukocyte chemotaxis, inflammatory cytokine production, and immune function. There is a view that an excess of n-6 fatty acids should be avoided since this could contribute to a state where physiological processes become dysregulated. One alternative is the use of fish oil. The rationale of this latter approach is that fish oil contains long chain n-3 fatty acids, such as eicosapentaenoic acid. When fish oil is provided, eicosapentaenoic acid is incorporated into cell membrane phospholipids, partly at the expense of arachidonic acid. Thus, there is less arachidonic acid available for eicosanoid synthesis. Hence, fish oil decreases production of prostaglandins like PGE2 and of leukotrienes like LTB4. Thus, n-3 fatty acids can potentially reduce platelet aggregation, blood clotting, smooth muscle contraction, and leukocyte chemotaxis, and can modulate inflammatory cytokine production and immune function. These effects have been demonstrated in cell culture, animal feeding and healthy volunteer studies. Fish oil decreases the host metabolic response and improves survival to endotoxin in laboratory animals. Recently clinical studies performed in various patient groups have indicated benefit from this approach.

  7. Feminism and liberalism: a not-so-unhappy marriag

    Directory of Open Access Journals (Sweden)

    Carla Saen

    2006-01-01

    Full Text Available It seems that political liberalism and feminism constitute an “unhappy marriage.” I shall argue that it should be a happy one.  Liberalism does more feminist work than feminist theorists acknowledge. Feminist theorists raise both internal and external critiques.  Some of the internal critiques are ungrounded and based on misinterpretation of key liberal concepts, while others can be accommodated by revisingthe liberal framework.  In contrast, the external criticisms, which are presented as a definitive challenge to liberalism, are unsuccessful.  They themselves implicitly rely on some key liberal assumptions, which shows that they are ultimately internal critiques. My primary aim in this paper is to show that the feminist critiques remain within a liberal framework.  Feminists also claim that liberal theory is incompatible with current facts about gender.  I shall call these “inefficacy critiques.”  As my secondary aim I shall show that this  critique of liberalism relies on a misunderstanding of the distinction between normative and descriptive claims

  8. Does classical liberalism imply democracy?

    Directory of Open Access Journals (Sweden)

    David Ellerman

    2015-12-01

    Full Text Available There is a fault line running through classical liberalism as to whether or not democratic self-governance is a necessary part of a liberal social order. The democratic and non-democratic strains of classical liberalism are both present today—particularly in the United States. Many contemporary libertarians and neo-Austrian economists represent the non-democratic strain in their promotion of non-democratic sovereign city-states (start-up cities or charter cities. We will take the late James M. Buchanan as a representative of the democratic strain of classical liberalism. Since the fundamental norm of classical liberalism is consent, we must start with the intellectual history of the voluntary slavery contract, the coverture marriage contract, and the voluntary non-democratic constitution (or pactum subjectionis. Next we recover the theory of inalienable rights that descends from the Reformation doctrine of the inalienability of conscience through the Enlightenment (e.g. Spinoza and Hutcheson in the abolitionist and democratic movements. Consent-based governments divide into those based on the subjects’ alienation of power to a sovereign and those based on the citizens’ delegation of power to representatives. Inalienable rights theory rules out that alienation in favor of delegation, so the citizens remain the ultimate principals and the form of government is democratic. Thus the argument concludes in agreement with Buchanan that the classical liberal endorsement of sovereign individuals acting in the marketplace generalizes to the joint action of individuals as the principals in their own organizations.

  9. Liberal values and political stabilization in Serbia

    Directory of Open Access Journals (Sweden)

    Pavićević Đorđe M.

    2002-01-01

    Full Text Available The paper is an expanded version of the project proposal 'Liberal values and political stabilization in Serbia'. The idea of the proposal is to explore the possibilities of acceptance and stabilization of liberal patterns of distribution of social goods in transitional countries, keeping in mind peculiarities of the Serbian case. Liberalization of these countries is usually an uneasy and uncertain process. There are two kind paradoxes of liberalization. The first concerns the necessity of political incentives for depoliticization of several social spheres. The second is related to possible self-destructive performances of liberal institutions in the process of transition. The stabilization of liberal-democracy in transitional countries is dependent on the capacity of institutions to build within themselves the mechanisms for alleviating these uneasiness. Two of them I find especially important: the system of social responsibilities and public reason.

  10. Linguistic performance of the liberal truth in russia: from the imperial liberalism of the 19th century to the presidential liberalism of the 20th century

    OpenAIRE

    Khalina, Natalia

    2017-01-01

    Abstract The article is devoted to the problems of linguistic performance in modern Russian political reality. The main theme is the theme of presidential liberalism which is connected with imperial liberalism. The linguistic features of presidential liberalism in Modern Russia are depicted in this article. Rezumat În articol, se abordează problema performanţei linguale din sfera politică rusească contemporană. Tema principală, supusă analizei, este liberalismul prezidenţial care ...

  11. Agricultural Liberalization in the Doha Round

    OpenAIRE

    Messerlin , Patrick

    2005-01-01

    The analysis of agricultural liberalization reveals very large potential gains for both developed and developing countries that will come especially from own-country liberalization as well as from inter-country trade, significant benefits that may be realized by the poorest developing countries, and limited benefits from existing preferential agricultural arrangements. An ideal program for agricultural liberalization in the Doha Round would involve substantial reductions in the high tariffs t...

  12. Marxism, Liberalism, and Educational Theory.

    Science.gov (United States)

    Margonis, Frank

    1993-01-01

    Examines educational theory, Marxism, and liberalism, discussing Kenneth Strike's "Liberal Justice and the Marxist Critique of Education" and Daniel Liston's "Capitalist Schools: Explanation and Ethics in Radical Studies of Schooling." Suggests that both authors are too hasty in abandoning Marxism and that Marxism is the…

  13. Clinical benefits of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease are not related to urinary eicosanoid release and are accompanied with decreased urine creatinine.

    Science.gov (United States)

    Makowska, Joanna S; Olszewska-Ziąber, Agnieszka; Bieńkiewicz, Barbara; Lewandowska-Polak, Anna; Kurowski, Marcin; Woźniakowski, Bartłomiej; Rotkiewicz, Arkadiusz; Kowalski, Marek L

    2016-05-01

    Treatment with acetylsalicylic acid (ASA) after desensitization may be a therapeutic option in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). The mechanisms that lead to improvement in rhinosinusitis and asthma symptoms remain unknown. To attribute the documented clinical effects of ASA treatment of chronic rhinosinusitis and/or asthma to the release of eicosanoid metabolites in urine. Fourteen patients with NERD were successfully desensitized, and, eventually, eight patients were treated with 650 mg of ASA daily for 3 months. In addition to clinical assessments, nuclear magnetic resonance imaging and smell test were performed before and after treatment with ASA. Venous blood and urine were collected before desensitization and after 1 and 3 months of treatment. The levels of urinary leukotrienes (LT) (cysteinyl LT and LTE4) and tetranor PGDM (metabolite of prostaglandin D2) were measured by enzyme-linked immunosorbent assay. Treatment with ASA after desensitization alleviated symptoms of rhinosinusitis, improved nasal patency (mean, 50% decrease in peak nasal inspiratory flow) and sense of smell (fourfold increase in smell test score) in as early as 4 weeks. Clinical improvements were not accompanied by any change in sinonasal mucosa thickness as assessed with nuclear magnetic resonance. Urinary cysteinyl LTs, LTE4, and prostaglandin D2 metabolite remained relatively stable during ASA treatment and did not correlate with clinical improvements. Desensitization was associated with a progressive decrease of urinary creatinine. Clinical improvement in rhinosinusitis and/or asthma after ASA desensitization was not related to concentrations of urinary eicosanoid metabolites. A decrease of urinary creatinine requires further study to determine the renal safety of long-term treatment with ASA after desensitization.

  14. A Liberal Account of Self-limiting Individualism

    NARCIS (Netherlands)

    van den Brink, H.H.A.; Harskamp, Anton van; Musschenga, Albert W.

    2001-01-01

    In this essay I aim to show that a doctrine of self-limiting individualism is presupposed by the most influential account of liberalism today, political liberalism. My argument is that political liberalism can admit that it is based on a rather comprehensive normative ideal of individualism, without

  15. Determination of the Relative Atomic Masses of Metals by Liberation of Molecular Hydrogen

    Science.gov (United States)

    Waghorne, W. Earle; Rous, Andrew J.

    2009-01-01

    Students determine the relative atomic masses of calcium, magnesium, and aluminum by reaction with hydrochloric acid and measurement of the volume of hydrogen gas liberated. The experiment demonstrates stoichiometry and illustrates clearly that mass of the reagent is not the determinant of the amounts in chemical reactions. The experiment is…

  16. Speech Communication and Liberal Education.

    Science.gov (United States)

    Bradley, Bert E.

    1979-01-01

    Argues for the continuation of liberal education over career-oriented programs. Defines liberal education as one that develops abilities that transcend occupational concerns, and that enables individuals to cope with shifts in values, vocations, careers, and the environment. Argues that speech communication makes a significant contribution to…

  17. Politisk liberalism och skolans religionsundervisning

    Directory of Open Access Journals (Sweden)

    Joachim Rosenquist

    2007-01-01

    Full Text Available POLITICAL LIBERALISM AND RELIGIOUS EDUCATION. Based on John Rawls’ latertheory of political liberalism, this article critically analyses what religiouseducation could mean in times of increasing societal pluralism and a world-wide revival of religion. Important elements of political liberalism – such asthe notions of reasonable persons and public reason – are elaborated onand related to religious individuals and perspectives. It is argued that polit-ical liberalism supports mandatory religious education, but of a certainkind. Schools have an obligation to provide students with knowledge aboutreligions, and to foster a spirit of tolerance and respect for the demands ofpublic reason. But they cannot legitimately give students the impression thatall religions are equally true or false. This makes for a problematic situation:how is it possible to teach students about religion without crossing the lineand teaching religious relativism? If it is not possible, then political liberalismseems to be more controversial than Rawls would admit.

  18. Pragmatic Liberalism and President Obama

    Directory of Open Access Journals (Sweden)

    Haroon A. Khan

    2014-06-01

    Full Text Available This research seeks to examine the foreign policy of President Obama with special reference to Bangladesh from the point of pragmatic liberalism. Pragmatism means understanding the realities of the situation and making decisions based on thorough research of these realities. Pragmatism opposes strict adherence to ideological beliefs in pursuing foreign policy. President Obama came into power amid one of the most volatile and dangerous times in the history of the United States occupied with two foreign wars, and inherited an economy on the brink of collapse. The key features of Obama’s pragmatic liberalism in foreign policy are to promote liberal ideas as long as it does not threaten the national security interests, emphasize diplomacy in solving the conflicts, foster humanitarian issues, develop alliances and multilateral agreements, uphold the major national interests, and strengthen national security defined in terms of economic well-being. The article will analyze U.S. foreign policy toward Bangladesh based on pragmatic liberalism of President Obama.

  19. Political liberalism and religious claims: Four blind spots.

    Science.gov (United States)

    Stoeckl, Kristina

    2017-01-01

    This article gives an overview of 4 important lacunae in political liberalism and identifies, in a preliminary fashion, some trends in the literature that can come in for support in filling these blind spots, which prevent political liberalism from a correct assessment of the diverse nature of religious claims. Political liberalism operates with implicit assumptions about religious actors being either 'liberal' or 'fundamentalist' and ignores a third, in-between group, namely traditionalist religious actors and their claims. After having explained what makes traditionalist religious actors different from liberal and fundamentalist religious actors, the author develops 4 areas in which political liberalism should be pushed further theoretically in order to correctly theorize the challenge which traditional religious actors pose to liberal democracy. These 4 areas (blind spots) are: (1) the context of translation; (2) the politics of exemptions; (3) the multivocality of theology; and (4) the transnational nature of norm-contestation.

  20. Multiculturalism and the Mission of Liberal Education.

    Science.gov (United States)

    Aleman, Ana M. Martinez; Salkever, Katya

    This paper examines attempts at four prototypical undergraduate liberal arts colleges to build community based on liberal educational principles and values, and investigates liberal education's ability to meet the challenges of multiculturalism. Data for the study was derived from a content analysis of archival materials from the four colleges,…

  1. Was Montesquieu a Liberal Republican?

    NARCIS (Netherlands)

    de Dijn, A.

    2014-01-01

    This paper sets out to criticize Thomas Pangle's and Paul Rahe's reading of The Spirit of the Laws as a contribution to liberal republicanism, arguing instead that Montesquieu's text is better understood as a defense of liberal monarchism. Pangle's and Rahe's interpretation of The Spirit of the Laws

  2. Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction

    Directory of Open Access Journals (Sweden)

    N. Nathan

    1997-01-01

    Full Text Available Multible organ failure (MOF induced by mesenteric infarction is associated with a high mortality rate. This study reports eicosanoid and cytokine levels in the blood of three atherosclerotic patients who ultimately died from MOF induced by mesenteric infarction. High plasma levels of 6- keto-prostaglandin (PG F1α (the stable metabolite of PGI2, interleukin (IL-6 and IL-8 are observed whereas plasma tumour necrosis factor alpha (TNFα, TxB2 (the stable metabolite of TxA2, PGE2, leukotrienes (LTB4 and LTC4, and whole blood platelet-activating factor levels are not different from values obtained in similarly severe atherosclerotic patients. This short report questioned the clinical involvement of TNFα during such a pathology where a persistent translocation of endotoxin has been observed through the gut endothelial barrier. Activation of phospholipase A2 is suggested by the increase in the stable metabolite of PGI2 and might be by itself or through lipidic metabolites, a major systemic stimulus of IL-6 and IL-8 production.

  3. The Paradoxes of Liberalism

    DEFF Research Database (Denmark)

    Thompson, Grahame

    2011-01-01

    Jakob Vestergaard has produced one of the most telling analyses of the international financial architecture by deploying a broadly Foucauldian framework that invokes a novel description of neo-liberal governance, one organized around discipline, conditional exceptions and the pursuit of a ‘proper...... economy’. This review both welcomes but challenges some of Vestergaard's analysis. In so doing it explores further the paradoxes of liberalism and the fate of sovereignty in the current international context....

  4. Sustainability of Trade Liberalization and Antidumping: Evidence from Mexico’s Trade Liberalization toward China

    Directory of Open Access Journals (Sweden)

    Yi Liu

    2015-08-01

    Full Text Available A Negative Binomial Regression Model is used to investigate the sustainability of China–Mexico trade liberalization by testing the tariff lines underpinning Mexico’s successful antidumping (AD measures against Chinese imports from 1991 to 2011. Evidence shows import tariff cutting and consumption growth have a positive impact on consumer goods but a negative impact on intermediaries. This result implies that while the Mexican government has expended considerable energy on the trade liberalization of intermediate and capital goods, the domestic consumer goods market has been protected from Chinese imports. The empirical results indicate that Mexico’s AD use for consumer goods helps to sustain trade liberalization of intermediate and capital goods under the domestic political pressures for trade opening.

  5. Exporting EU Liberalism Eastwards

    Directory of Open Access Journals (Sweden)

    Lynn M. Tesser

    2009-07-01

    Full Text Available There is much more to liberalism in the post communist context than has been acknowledged. A sizeable effort has indeed emerged to transplant a relatively coherent liberal ideology to the region, one exported not merely through the conditionality of international financial institutions, but also through the conditionality and socialization of organizations like the NATO, OSCE, EU, and the Council of Europe. ‘EU liberalism’ includes the ‘standard’ liberal emphasis on individual rights, the rule of law, constitutional democracy, freedom, and market economics as well as support for minority rights, and a seemingly schizophrenic emphasis on economic integration that involves, first bringing down borders for the free movement of people, goods, capital, and services between member states, and second, market regulation to diminish the social downsides of capitalism. This paper outlines EU liberalism’s emergence and its application to Central and East European countries.

  6. Machiavelli and the liberalism of fear

    OpenAIRE

    Osborne, Thomas

    2017-01-01

    This article revisits the long-standing question of the relations between ethics and politics in Machiavelli’s work, assessing its relevance to the ‘liberalism of fear’ in particular in the work of Judith Shklar, Bernard Williams and also John Dunn. The article considers ways in which Machiavelli has been a ‘negative’ resource for liberalism – for instance, as a presumed proponent of tyranny; but also ways in which even for the liberalism of fear he might be considered a ‘positive’ resource, ...

  7. Individual and Group Rights of Liberal Multiculturalism

    Directory of Open Access Journals (Sweden)

    Vesna Stanković Pejnović

    2010-08-01

    Full Text Available The paper discusses the implementation of minority members’ protection through political and civil rights. In the debates on minority members’ rights, the issue is whether the very individual rights of traditional liberalism are sufficient for minority members’ protection or if there is a need for group rights based on liberal principles of justice, equality and freedom. On these foundations, liberal multiculturalism considers that it is necessary to introduce group rights in order to be used by minority members, but as individual group members. Liberal multiculturalism’s perception of group rights is based on liberal postulates of respect for freedom and individuals’ autonomy, at the same time introducing the recognition of diversity imposed by multiculturalism in its conception of minority rights protection. The author concludes that minority rights, taking into account their internationalisation, should be regarded as a supplement to the perception of classical and contemporary liberalism, because correctly perceived individual rights conception does not neglect cultural diversities. The importance of such perception of minority protection is also visible within the framework proposed by the EU as an obligatory condition for the integration of future member states.

  8. A Christian identity for the liberal state?

    Science.gov (United States)

    Joppke, Christian

    2013-12-01

    It seems to be impossible for the liberal state to embrace a Christian identity, because 'liberalism' is exactly a device for separating state and religion. Discussing the implications of a recent decision of the European Court of Human Rights, Lautsi v. Italy (2011), I argue that this is not necessarily so. If paired with a liberal commitment to pluralism, a Christian identity might even be more inclusive of minority religions than a narrowly 'liberal' state identity, which has been the dominant response in Western Europe to the challenge of immigrant diversity, especially that of Muslim origins. © London School of Economics and Political Science 2013.

  9. Machiavelli and the liberalism of fear.

    Science.gov (United States)

    Osborne, Thomas

    2017-12-01

    This article revisits the long-standing question of the relations between ethics and politics in Machiavelli's work, assessing its relevance to the 'liberalism of fear' in particular in the work of Judith Shklar, Bernard Williams and also John Dunn. The article considers ways in which Machiavelli has been a 'negative' resource for liberalism - for instance, as a presumed proponent of tyranny; but also ways in which even for the liberalism of fear he might be considered a 'positive' resource, above all around the issues of political necessity and prudential judgement.

  10. Populisms and liberal democracy – business as usual?

    DEFF Research Database (Denmark)

    Thompson, Grahame Frederick

    2017-01-01

    Populism is often thought to mark a sharp break with liberal democracy. But to what extent is this the case? In this contribution the connections between populism and liberal democracy are sketched in the context of several areas where discussions about populisms have stressed their discontinuity...... in these relationships. The contribution ends with a discussion of how it might be possible to defend liberal democracy from a non-liberal position in the face of the critique from populisms....

  11. FITS Liberator: Image processing software

    Science.gov (United States)

    Lindberg Christensen, Lars; Nielsen, Lars Holm; Nielsen, Kaspar K.; Johansen, Teis; Hurt, Robert; de Martin, David

    2012-06-01

    The ESA/ESO/NASA FITS Liberator makes it possible to process and edit astronomical science data in the FITS format to produce stunning images of the universe. Formerly a plugin for Adobe Photoshop, the current version of FITS Liberator is a stand-alone application and no longer requires Photoshop. This image processing software makes it possible to create color images using raw observations from a range of telescopes; the FITS Liberator continues to support the FITS and PDS formats, preferred by astronomers and planetary scientists respectively, which enables data to be processed from a wide range of telescopes and planetary probes, including ESO's Very Large Telescope, the NASA/ESA Hubble Space Telescope, NASA's Spitzer Space Telescope, ESA's XMM-Newton Telescope and Cassini-Huygens or Mars Reconnaissance Orbiter.

  12. A new model to study the role of arachidonic acid in colon cancer pathophysiology

    OpenAIRE

    Fan, Yang-Yi; Callaway, Evelyn; Monk, Jennifer M.; Goldsby, Jennifer S.; Yang, Peiying; Vincent, Logan; Chapkin, Robert S.

    2016-01-01

    A significant increase in cyclooxygenase 2 (COX2) gene expression has been shown to promote cylcooxygenase-dependent colon cancer development. Controversy associated with the role of COX2 inhibitors indicates that additional work is needed to elucidate the effects of arachidonic acid (AA) derived (cyclooxygenase and lipoxygenase) eicosanoids in cancer initiation, progression and metastasis. We have recently developed a novel Fads1 knockout mouse model, which allows for the investigation of AA...

  13. The liberal battlefields of global business regulation

    Directory of Open Access Journals (Sweden)

    Kate Macdonald

    2010-11-01

    Full Text Available The global justice movement has often been associated with opposition to the broad programme of ‘neoliberalism’ and associated patterns of ‘corporate globalisation’, creating a widespread impression that this movement is opposed to liberalism more broadly conceived. Our goal in this article is to challenge this widespread view. By engaging in critical interpretive analysis of the contemporary ‘corporate accountability’ movement, we argue that the corporate accountability agenda is not opposed to the core values of a liberal project. Rather, it is seeking to reconfigure the design of liberal institutions of individual rights-protection, adjusting these for new material conditions associated with economic globalisation, under which powerful corporations alongside states now pose direct and significant threats to individual rights. This activist agenda is, therefore, much less radical in its challenge to the prevailing liberal global order than it may initially appear, since it functions to buttress rather than corrode many core normative commitments underpinning the liberal political project.

  14. John Deweys kritik af liberal education

    DEFF Research Database (Denmark)

    Huggler, Jørgen

    2017-01-01

    The paper deals with John Dewey's aversion against liberal education and his concern about a 'dual track' educational system separating liberal education and vocational education. It investigates the reason why Dewey maintains that the philosophical 'dualisms' culminate in the question on vocation....

  15. 49 CFR 1100.3 - Liberal construction.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Liberal construction. 1100.3 Section 1100.3 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION BOARD, DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE GENERAL PROVISIONS § 1100.3 Liberal construction. The rules will...

  16. Pulmonary arachidonic acid metabolism following acute exposures to ozone and nitrogen dioxide

    International Nuclear Information System (INIS)

    Schlesinger, R.B.; Driscoll, K.E.; Gunnison, A.F.; Zelikoff, J.T.

    1990-01-01

    Ozone (O 3 ) and nitrogen dioxide (NO 2 ) are common air pollutants, and exposure to these gases has been shown to affect pulmonary physiology, biochemistry, and structure. This study examined their ability to modulate arachidonic acid metabolites (eicosanoids) in the lungs. Rabbits were exposed for 2 h to O 3 at 0.1, 0.3, or 1 ppm; NO 2 at 1, 3, or 10 ppm; or to a mixture of 0.3 ppm O 3 and 3 ppm NO 2 . Groups of animals sacrificed either immediately or 24 h after each exposure underwent broncho-pulmonary lavage. Selected eicosanoids were assessed in lavage fluid by radioimmunoassay. Increases in prostaglandins E2 (PGE2) and F2 alpha (PGF2 alpha) were found immediately after exposure to 1 ppm O 3 . Exposure to 10 ppm NO 2 resulted in a depression of 6-keto-PGF1 alpha, while thromboxane B2 (TxB2) was elevated after exposure to 1 ppm NO 2 and depressed following 3 and 10 ppm. The O 3 /NO 2 mixture resulted in synergistic increases in PGE2 and PGF2 alpha, with the response appearing to be driven by O 3 . This study has demonstrated that acute exposure to either O 3 or NO 2 can alter pulmonary arachidonic acid metabolism and that the responses to these oxidants differ, both quantitatively and qualitatively

  17. Liberalism, authority, and bioethics commissions.

    Science.gov (United States)

    MacDougall, D Robert

    2013-12-01

    Bioethicists working on national ethics commissions frequently think of themselves as advisors to the government, but distance themselves from any claims to actual authority. Governments however may find it beneficial to appear to defer to the authority of these commissions when designing laws and policies, and might appoint such commissions for exactly this reason. Where does the authority for setting laws and policies come from? This question is best answered from within a normative political philosophy. This paper explains the locus of moral authority as understood within one family of normative political theories--liberal political theories--and argues that most major "liberal" commentators have understood both the source and scope of ethics commissions' authority in a manner at odds with liberalism, rightly interpreted. The author argues that reexamining the implications of liberalism for bioethics commissions would mean changing what are considered valid criticisms of such commissions and also changing the content of national bioethics commission mandates. The author concludes that bioethicists who participate in such commissions ought to carefully examine their own views about the normative limits of governmental authority because such limits have important implications for the contribution that bioethicists can legitimately make to government commissions.

  18. Prices and tariffs in a liberalized electricity market

    International Nuclear Information System (INIS)

    Rijkers, F.; Wals, A.; Battjes, C.; Scheepers, M.

    2000-01-01

    First, it is described how prices and tariffs were determined before the introduction of the liberalization. Next, a brief overview is given of the transfer to the liberalized market and how the situation is on this market at present. Special attention is paid to the pricing of electricity in a free market, which is determined by competition between electricity producers in the Netherlands and abroad. Finally, a comparison is made between the expected prices and tariffs in a liberalized market and the prices before the liberalization

  19. National Versus International Mergers and Trade Liberalization

    OpenAIRE

    Yildiz, Halis Murat

    2003-01-01

    This paper uses an endogenous merger formation approach in a concentrated international oligopoly to examine the effects of trade liberalization on the nature of merger incentives (national vs. international). The effects of unilateral trade liberalization on a country’s industry structure are found to be depending on the other country’s trade policy regime. If the other country practices free trade, unilateral liberalization by a country yields international mergers whereas if it practices a...

  20. Economic and Political Liberalization in Tanzania and its ...

    African Journals Online (AJOL)

    With the onset of globalization one-party state regimes were forced to liberalize politically and economically. Liberalization was seen as beneficial for it opened up both the political and economic space for all actors in the development process. Liberalization was embraced because of its perceived advantages to all sections ...

  1. Case Studies of Liberal Arts Computer Science Programs

    Science.gov (United States)

    Baldwin, D.; Brady, A.; Danyluk, A.; Adams, J.; Lawrence, A.

    2010-01-01

    Many undergraduate liberal arts institutions offer computer science majors. This article illustrates how quality computer science programs can be realized in a wide variety of liberal arts settings by describing and contrasting the actual programs at five liberal arts colleges: Williams College, Kalamazoo College, the State University of New York…

  2. The Rise and Fall of Liberal Peace in Libya

    Directory of Open Access Journals (Sweden)

    Siyum Adugna Mamo

    2018-01-01

    Full Text Available In the wake of the 2011 “Arab Uprising”, liberal elements were haunting in Tunisia, Egypt and Libya – countries which experienced the uprising at its early stage. The liberal elements triggered the youth particularly in Libya to boldly oppose their long-serving Libyan president, Muammar Qaddafi. In what followed, the West not only interfered to help the rebels and become involved in a direct military intervention in the guise of humanitarian intervention, it also tried to install a liberal peace in the process of state reconstruction and peacebuilding in the aftermath of the revolution that ousted Qaddafi. The intervention had an implicit agenda of regime change and installing liberal peace in post-Qaddafi Libya. However, the intervention descended the country into a protracted civil war that the country has been suffering from for more than six years after the downfall of Qaddafi, instead of bringing peace and stability to the Libyans. The liberal peace that was rising during the revolution and immediately after the fall of Qaddafi through the liberal ideals that triggered the Libyan revolutionaries ruptured as the country descended into protracted civil war among different factions due to Western intervention. The aim of this desk research is therefore to unpack the rise and fall of liberal peace in Libya. Employing discussion of the debate over liberal peace in Libya as a core methodological analysis, this paper argues that the liberal peace that the West attempted to install in the country failed mainly because it was rooted in hegemonic liberal values, which are incompatible with Libyan tribal society, and disregarded the indigenous peacebuilding mechanisms. This paper concludes that liberal peace, which privileges the international over the local, is irreconcilable with post-conflict environments in the Global South and hence was unable to solve the Libyan crises. Therefore, emphasis should be given to indigenous peacebuilding

  3. The Effect of Different Starch Liberation and Saccharification Methods on the Microbial Contaminations of Distillery Mashes, Fermentation Efficiency, and Spirits Quality

    Directory of Open Access Journals (Sweden)

    Katarzyna Pielech-Przybylska

    2017-09-01

    Full Text Available The aim of this study was to evaluate the influence of different starch liberation and saccharification methods on microbiological contamination of distillery mashes. Moreover, the effect of hop α-acid preparation for protection against microbial infections was assessed. The quality of agricultural distillates was also evaluated. When applying the pressureless liberation of starch (PLS and malt as a source of amylolytic enzymes, the lactic acid bacteria count in the mashes increased several times during fermentation. The mashes obtained using the pressure-thermal method and malt enzymes revealed a similar pattern. Samples prepared using cereal malt exhibited higher concentrations of lactic and acetic acids, as compared to mashes prepared using enzymes of microbial origin. The use of hop α-acids led to the reduction of bacterial contamination in all tested mashes. As a result, fermentation of both mashes prepared with microbial origin enzyme preparations and with barley malt resulted in satisfactory efficiency and distillates with low concentrations of aldehydes.

  4. The Effect of Different Starch Liberation and Saccharification Methods on the Microbial Contaminations of Distillery Mashes, Fermentation Efficiency, and Spirits Quality.

    Science.gov (United States)

    Pielech-Przybylska, Katarzyna; Balcerek, Maria; Nowak, Agnieszka; Wojtczak, Maciej; Czyżowska, Agata; Dziekońska-Kubczak, Urszula; Patelski, Piotr

    2017-09-30

    The aim of this study was to evaluate the influence of different starch liberation and saccharification methods on microbiological contamination of distillery mashes. Moreover, the effect of hop α-acid preparation for protection against microbial infections was assessed. The quality of agricultural distillates was also evaluated. When applying the pressureless liberation of starch (PLS) and malt as a source of amylolytic enzymes, the lactic acid bacteria count in the mashes increased several times during fermentation. The mashes obtained using the pressure-thermal method and malt enzymes revealed a similar pattern. Samples prepared using cereal malt exhibited higher concentrations of lactic and acetic acids, as compared to mashes prepared using enzymes of microbial origin. The use of hop α-acids led to the reduction of bacterial contamination in all tested mashes. As a result, fermentation of both mashes prepared with microbial origin enzyme preparations and with barley malt resulted in satisfactory efficiency and distillates with low concentrations of aldehydes.

  5. Negative freedom and the liberal paradoxes

    NARCIS (Netherlands)

    van Hees, M.V.B.P.M

    In their game-theoretic formulations, the liberal paradoxes of Amartya Sm and Alan Gibbard show a tension between freedom on the one hand, and Pareto optimality and stability on the other. This article examines what happens to the liberal paradoxes if a negative conception of freedom is used. Given

  6. Welfare Rights in the Liberal Tradition.

    Science.gov (United States)

    Horne, Thomas A.

    1990-01-01

    Maintains that welfare rights are not incompatible with liberalism's commitment to private property and freedom. Argues that students need to be aware of liberalism's favorable historical position on welfare. Examines the positions of John Locke, Thomas Paine, and John Stuart Mills on poverty, welfare, and the role of the state. (RW)

  7. AAAC&U's Integrative Liberal Learning and the CAS Standards: Advising for a 21st Century Liberal Education

    Science.gov (United States)

    Robbins, Rich

    2014-01-01

    The Association of American Colleges and Universities presented and promoted integrative liberal learning as a collaborative goal that all institutions of higher education must strive to achieve. The similarities between the goals of integrative liberal learning and the Standards for Academic Advising by the Council for the Advancement of…

  8. The poverty of liberal economics

    OpenAIRE

    Brady, David

    2003-01-01

    Liberal economic precepts have long been a foundation for the social science of poverty and continue to profoundly influence public policy. Liberal economics contends that poverty is dependent on the harmonious progress of economic growth, free market capitalism, worker productivity, and the supply and demand of labor. This paper traces its origins from classical economics and its influence throughout contemporary social science, public policy and conventional wisdom. Next, I evaluate the lib...

  9. Investment under Financial Liberalization: Post 1980 Turkey Case

    Directory of Open Access Journals (Sweden)

    Onur TUTULMAZ

    2015-02-01

    Full Text Available In the history of the modern state of Turkey many policies have been developed and applied in order to transform ineffective economy to a dynamic and steady one. The liberal policies have been effectively applied except for war periods. The main activity of liberal policies in Turkey’s economy was conducted on January 24, 1980 with some important structural adjustment decisions. These decisions aimed to integrate the economy with the global system by applying global economic order that widely adopted all over the world. The decisions aimed also to activate a financial liberalization in the country. Financial liberalization generally includes the principles related to the removing the pressure on the interest rate, currency control and investment mobility. More liberalization steps came in 1989 aiming to increase the investment and growth. Foreign Direct Investment (FDI was seen important for that purposes. However, short term capital flows, having been more effective in real investments than FDI, have led to several negative effects in this period. In the study some of the drawbacks of that process of financial liberalization have been discussed. The relation between FDI and Gross Domestic Product in the financial liberalization process has been tested with econometric implementation. Econometric estimation has been applied for this purpose to test this relationship for post 1980 era for Turkey as a developing country.

  10. Liberal Education: A Literary Black Hole?

    Science.gov (United States)

    Pederson, Tom

    1989-01-01

    An overview of the historical traditions presented by Bruce Kimball in his "Orators and Philosophers: A History of the Idea of Liberal Education" is presented. The significance of the structure of the Catholic and other Christian churches in perpetuating the ideal and reality of a liberal arts education is discussed. (Author/MLW)

  11. Luther, Learning, and the Liberal Arts

    Science.gov (United States)

    Burnett, Amy Nelson

    2017-01-01

    The learning goals of a well-designed course in the liberal arts include not only the imparting of knowledge but also the development of critical thinking and disciplinary expertise. A class on Luther can help students acquire those intellectual skills associated with the discipline of history and the liberal arts more generally as they consider…

  12. Liberalism and democracy Liberalismo e democracia

    Directory of Open Access Journals (Sweden)

    (Autor Claude Lefort

    2008-12-01

    Full Text Available In this essay, the historical connections between liberalism and democracy are analyzed, based mostly on three important authors of the French liberal thought of the first half of the 19th century: Benjamin Constant (1767-1830, François Guizot (1787-1874 e Alexis de Tocqueville (1805-1859. Although, the Author doesn’t forget to highlight the contemporary issues which demand confronting and elucidating the chances of democracy. Keywords: French Liberalism. Democracy. Political Philosophy. Tolerance. São aqui examinadas as relações históricas entre liberalismo e democracia, com base principalmente em três importantes autores do pensamento liberal francês da primeira metade do século XIX: Benjamin Constant (1767-1830, François Guizot (1787-1874 e Alexis de Tocqueville (1805-1859. Contudo, o Autor não deixa de lançar luz sobre as questões contemporâneas que exigem enfrentar e elucidar as chances da democracia. Palavras-chave: Liberalismo francês. Democracia. Filosofia política. Tolerância.

  13. Which Companies Benefit form Liberalization?

    DEFF Research Database (Denmark)

    Baghdasaryan, Delia; la Cour, Lisbeth; Schneider, Cédric

    2016-01-01

    Theoretical research shows that competition has positive effects on productivity, for companies that are initially efficient, but not for unproductive firms. Our empirical analysis on a panel data of Czech companies, years 1995–2004, confirms this result. In addition, our analysis shows that when...... economic reforms affect both domestic and foreign competition, controlling for domestic competition is crucial when assessing the impact of trade liberalization. Otherwise, the effect of trade liberalization on firm productivity is upward biased....

  14. THE LIBERAL ARTS--PAST, PRESENT, FUTURE.

    Science.gov (United States)

    RICE, JAMES G.

    THE STERILITY OF THE LIBERAL ARTS IN MOST COLLEGES TODAY IS BECOMING MORE EVIDENT. STUDENTS ARE TURNING TO "POT," LSD, OR IMMERSIONS IN ANOTHER CULTURE IN THEIR QUESTS TO EXPAND THEIR CONSCIOUSNESS. THE STUDENT'S NEED FOR A HEIGHTENED AWARENESS AND LARGER FRAME OF REFERENCE CAN BE FULFILLED BY A STUDY OF THE LIBERAL ARTS ONLY IF THESE STUDIES ARE…

  15. The discourse of liberation: Frames used in characterising the gay liberation movement in two South African newspapers

    Directory of Open Access Journals (Sweden)

    Lauren Danger Mongie

    2015-09-01

    Full Text Available This article reports on the quantitative findings of a study that straddles the applied linguistic field of critical discourse analysis and a sociolinguistic field recently referred to as “queer linguistics”. Drawing on a quantitative method of analysis, the study investigates the linguistic framing of LGBT mobilisation in two South African newspapers, City Press and the Mail & Guardian, across a period of almost 30 years. It aims to identify the characteristics of the discourses that topicalise the gay[1] liberation movement in order to investigate the ways in which linguistic means have been used in articulating the need and the right to liberation and how arguments against the gay liberation movement have been framed, reframed and counterframed in South African media. The study’s findings revealed that a number of frames, including ‘liberation’, ‘rights’ and ‘victimisation’, reoccurred in the framing of arguments for the gay liberation movement throughout the data collection period in both corpora, and while City Press primarily used these frames to express anti-gay sentiments, the Mail & Guardian primarily used these frames to express pro-gay sentiments. The findings also revealed that a number of frames, including ‘religion’, ‘morality’ and ‘nature’, reoccurred in the framing of arguments against the gay liberation movement, and again while City Press primarily used these frames to express anti-gay sentiments, the Mail & Guardian primarily used these frames to express pro-gay sentiments. Finally, the findings revealed that a single frame such as “religion” was typically used to express both pro- and anti-gay sentiments, bringing to light the important role that counterframing plays in bringing about social transformation.[1] The word “gay” is used as a hypernym in this article as this is a reflection of the way in which the liberation movement was typically topicalised in the data.

  16. A New Model to Study the Role of Arachidonic Acid in Colon Cancer Pathophysiology.

    Science.gov (United States)

    Fan, Yang-Yi; Callaway, Evelyn; M Monk, Jennifer; S Goldsby, Jennifer; Yang, Peiying; Vincent, Logan; S Chapkin, Robert

    2016-09-01

    A significant increase in cyclooxygenase 2 (COX2) gene expression has been shown to promote cylcooxygenase-dependent colon cancer development. Controversy associated with the role of COX2 inhibitors indicates that additional work is needed to elucidate the effects of arachidonic acid (AA)-derived (cyclooxygenase and lipoxygenase) eicosanoids in cancer initiation, progression, and metastasis. We have recently developed a novel Fads1 knockout mouse model that allows for the investigation of AA-dependent eicosanoid deficiency without the complication of essential fatty acid deficiency. Interestingly, the survival rate of Fads1-null mice is severely compromised after 2 months on a semi-purified AA-free diet, which precludes long-term chemoprevention studies. Therefore, in this study, dietary AA levels were titrated to determine the minimal level required for survival, while maintaining a distinct AA-deficient phenotype. Null mice supplemented with AA (0.1%, 0.4%, 0.6%, 2.0%, w/w) in the diet exhibited a dose-dependent increase (P sibling littermate control mice. These data indicate that (i) basal/minimal dietary AA supplementation (0.6%) expands the utility of the Fads1-null mouse model for long-term cancer prevention studies and (ii) that AA content in the colonic epithelium modulates colon cancer risk. Cancer Prev Res; 9(9); 750-7. ©2016 AACR. ©2016 American Association for Cancer Research.

  17. ENDOCANNABINOIDS AND EICOSAMOIDS: BIOSYNTHESIS AND INTERACTIONS WITH IMMUNE RESPONSE

    Directory of Open Access Journals (Sweden)

    Yu. K. Karaman

    2013-01-01

    Full Text Available The review is dedicated to modern concepts of arachidonic acid metabolites, i.e., endocannabinoids and eicosanoids, their biosynthetic pathways, cross-talk mechanisms and participation in immune response. New information from literature and own results include data concerning overlapping enzymatic pathways controlling biosynthesis of endocannabinoids and eicosanoids. Impact of synthetic cannabinoid receptor ligands upon production rates of proinflammatory cytokines and eicosanoids is discussed, as like as relationships among immune system reactivity and expression levels of cannabinoid receptors.

  18. Role of eicosanoids and white blood cells in the beneficial effects of limited reperfusion after ischemia-reperfusion injury in skeletal muscle

    International Nuclear Information System (INIS)

    Anderson, R.J.; Cambria, R.A.; Dikdan, G.; Lysz, T.W.; Hobson, R.W. II

    1990-01-01

    Limiting the rate of reperfusion blood flow has been shown to be beneficial locally in models of ischemia-reperfusion injury. We investigated the effects of this on eicosanoids (thromboxane B2, 6-keto-PGF1 alpha, and leukotriene B4), white blood cell activation, and skeletal muscle injury as quantitated by triphenyltetrazolium chloride and technetium-99m pyrophosphate after ischemia-reperfusion injury in an isolated gracilis muscle model in 16 anesthetized dogs. One gracilis muscle in each dog was subjected to 6 hours of ischemia followed by 1 hour of limited reperfusion and then by a second hour of normal reperfusion. The other muscle was subjected to 6 hours of ischemia followed by 2 hours of normal reperfusion. Six dogs each were used as normal reperfusion controls (NR) and limited reperfusion controls (LR), with 5 dogs being treated with a thromboxane synthetase inhibitor (LR/TSI) and another five with a leukotriene inhibitor (LR/LI). LR in all three groups (LR, LR/TSI, and LR/LI) showed a benefit in skeletal muscle injury as measured by triphenyltetrazolim chloride and technetium-99m pyrophosphate when compared with NR. However, there was no significant difference between the groups with LR regarding eicosanoid levels and white blood cell activation when compared with NR. These results demonstrate that LR produces benefits by mechanisms other than those dependent upon thromboxane A2, prostacyclin, or white blood cell activation

  19. Dismantling the myth of pure Laissez-faire Liberalism

    DEFF Research Database (Denmark)

    Stahl, Rune Møller

    , Crouch 2011). But this insight is made by contrasting neoliberalism with classical liberalism, that is, explicit or implicitly, understood as being a full realisation of laissez-faire ideology. The paper will argue however, that 19th century liberalism, was also characterised by a tension between...... economic ideology and the actual practices of political economy. State action played a central role even during the heyday of laissez-faire liberalism....

  20. Mathematics for the liberal arts

    CERN Document Server

    Bindner, Donald; Hemmeter, Joe

    2014-01-01

    Presents a clear bridge between mathematics and the liberal arts Mathematics for the Liberal Arts provides a comprehensible and precise introduction to modern mathematics intertwined with the history of mathematical discoveries. The book discusses mathematical ideas in the context of the unfolding story of human thought and highlights the application of mathematics in everyday life. Divided into two parts, Mathematics for the Liberal Arts first traces the history of mathematics from the ancient world to the Middle Ages, then moves on to the Renaissance and finishes with the development of modern mathematics. In the second part, the book explores major topics of calculus and number theory, including problem-solving techniques and real-world applications. This book emphasizes learning through doing, presents a practical approach, and features: A detailed explanation of why mathematical principles are true and how the mathematical processes workNumerous figures and diagrams as well as hundreds of worked example...

  1. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina.

    Science.gov (United States)

    SanGiovanni, John Paul; Chew, Emily Y

    2005-01-01

    In this work we advance the hypothesis that omega-3 (omega-3) long-chain polyunsaturated fatty acids (LCPUFAs) exhibit cytoprotective and cytotherapeutic actions contributing to a number of anti-angiogenic and neuroprotective mechanisms within the retina. omega-3 LCPUFAs may modulate metabolic processes and attenuate effects of environmental exposures that activate molecules implicated in pathogenesis of vasoproliferative and neurodegenerative retinal diseases. These processes and exposures include ischemia, chronic light exposure, oxidative stress, inflammation, cellular signaling mechanisms, and aging. A number of bioactive molecules within the retina affect, and are effected by such conditions. These molecules operate within complex systems and include compounds classified as eicosanoids, angiogenic factors, matrix metalloproteinases, reactive oxygen species, cyclic nucleotides, neurotransmitters and neuromodulators, pro-inflammatory and immunoregulatory cytokines, and inflammatory phospholipids. We discuss the relationship of LCPUFAs with these bioactivators and bioactive compounds in the context of three blinding retinal diseases of public health significance that exhibit both vascular and neural pathology. How is omega-3 LCPUFA status related to retinal structure and function? Docosahexaenoic acid (DHA), a major dietary omega-3 LCPUFA, is also a major structural lipid of retinal photoreceptor outer segment membranes. Biophysical and biochemical properties of DHA may affect photoreceptor membrane function by altering permeability, fluidity, thickness, and lipid phase properties. Tissue DHA status affects retinal cell signaling mechanisms involved in phototransduction. DHA may operate in signaling cascades to enhance activation of membrane-bound retinal proteins and may also be involved in rhodopsin regeneration. Tissue DHA insufficiency is associated with alterations in retinal function. Visual processing deficits have been ameliorated with DHA supplementation

  2. Computer Science and the Liberal Arts: A Philosophical Examination

    Science.gov (United States)

    Walker, Henry M.; Kelemen, Charles

    2010-01-01

    This article explores the philosophy and position of the discipline of computer science within the liberal arts, based upon a discussion of the nature of computer science and a review of the characteristics of the liberal arts. A liberal arts environment provides important opportunities for undergraduate programs, but also presents important…

  3. Cultural bias and liberal neutrality: reconsidering the relationship between religion and liberalism through the lens of the physician-assisted suicide debate.

    Science.gov (United States)

    Jones, Robert P

    2002-01-01

    Liberals often view religion chiefly as "a problem" for democratic discourse in modern pluralistic societies and propose an allegedly neutral solution in the form of philosophical distinctions between "the right" and "the good" or populist invocations of a "right to choose." Drawing on cultural theory and ethnographic research among activists in the Oregon debates over the legalization of physician-assisted suicide, I demonstrate that liberal "neutrality" harbors its own cultural bias, flattens the complexity of public debates, and undermines liberalism's own commitments to equality. I conclude that the praiseworthy liberal goal of impartiality in policy decisions would best be met not by the inaccessible norm of neutrality but by a norm of inclusivity, which intentionally solicits multiple cultural perspectives.

  4. LIBERAL JOURNALISM AND AMERICAN EDUCATION, 1914-1941.

    Science.gov (United States)

    WALLACE, JAMES M.

    THE RELATIONSHIP BETWEEN TWO LIBERAL JOURNALS AND THE INSTITUTIONS AND PERSONNEL OF FORMAL EDUCATION WAS STUDIED. "THE NATION" AND "NEW REPUBLIC" WERE SELECTED AS BEING INFLUENTIALLY REPRESENTATIVE OF INTELLECTUAL AMERICAN LIBERALISM DURING THE 20TH CENTURY. STANDARD TECHNIQUES OF HISTORICAL RESEARCH WERE EMPLOYED. RELEVANT…

  5. Denmark between liberalism and nationalism

    DEFF Research Database (Denmark)

    Olsen, Tore Vincents; Mouritsen, Per

    2013-01-01

    What explains the restrictive turn towards immigrants in European countries like Denmark? Are countries returning to nationalism, or are they following a general European trend towards a perfectionist, even ‘repressive’ liberalism that seeks to create ‘liberal people’ out of immigrants? Recent...... developments in Danish policies of integration and citizenship, education and anti-discrimination suggest a combination of these two diagnoses. The current Danish ‘integration philosophy’ leaves behind a previous concern with private choice and equal rights and opportunities to emphasize other historical...

  6. The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains.

    Science.gov (United States)

    Allegrone, Gianna; Pollastro, Federica; Magagnini, Gianmaria; Taglialatela-Scafati, Orazio; Seegers, Julia; Koeberle, Andreas; Werz, Oliver; Appendino, Giovanni

    2017-03-24

    Canniprene (1), an isoprenylated bibenzyl unique to Cannabis sativa, can be vaporized and therefore potentially inhaled from marijuana. Canniprene (1) potently inhibited the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC 50 0.4 μM) and also affected the generation of prostaglandins via the cyclooxygenase/microsomal prostaglandin E 2 synthase pathway (IC 50 10 μM), while the related spiranoid bibenzyls cannabispiranol (2) and cannabispirenone (3) were almost inactive in these bioassays. The concentration of canniprene (1) was investigated in the leaves of 160 strains of C. sativa, showing wide variations, from traces to >0.2%, but no correlation was found between its accumulation and a specific phytocannabinoid profile.

  7. Renewing the Spirit of the Liberal Arts

    Science.gov (United States)

    Noddings, Nel

    2013-01-01

    The spirit of the liberal arts has been undermined by overspecialization, and it has been further damaged by the increase in emphasis on the economic purpose of education. The spirit might be renewed by using the aims of the liberal arts to develop every course we teach.

  8. The Liberal Arts and the Martial Arts.

    Science.gov (United States)

    Levine, Donald N.

    1984-01-01

    Liberal arts and the martial arts are compared from the perspective that courses of training in the martial arts often constitute exemplary educational programs and are worth examining closely. Program characteristics, individual characteristics fostered by them, the relationship between liberal and utilitarian learning, and the moral…

  9. "A Liberal Account of Self-Limiting Individualism"

    NARCIS (Netherlands)

    van den Brink, H.H.A.; Harskamp, Anton van; Musschenga, Albert W.

    2001-01-01

    In this essay I aim to show that a doctrine of self-limiting individualism, understood as a formal yet fairly comprehensive conception of how a person should lead her life and relate to others, is presupposed by the most influential account of liberalism today, political liberalism.

  10. Liberalization of the Swiss electricity and gas market

    International Nuclear Information System (INIS)

    Cattin, J.

    1999-01-01

    The Swiss government intends to liberalize the electricity and gas market. Competition is to be introduced in the electricity sector first because the European Union is also giving priority to this industry. Moreover, electricity prices in Switzerland are too high. The principle of market liberalization is not contested, but the route to be taken to achieve this goal is a matter of heated controversy. Opinions on the power line network, non-amortizable investments, hydropower plants or the pace of market liberalization still differ too widely. Liberalization of the gas market is also in preparation, but the problems here are less complex. This is because competition already exists on the heating market. In addition, domestic gas prices are not much higher than those charged in other countries. (author)

  11. Against liberal pluralist political practice in South Africa

    Directory of Open Access Journals (Sweden)

    Pieter Coetzee

    1997-03-01

    Full Text Available In this article I take issue with liberal pluralist political practice in South Africa. Multicultural civil society requires the recognition of cultural categories which modernity, in the shape of liberal pluralism, cannot accommodate and therefore ignore in the interests of fostering a single monocultural politics. In South Africa this trend has taken the usual route of difference-blind, assimilationisl political programmes aimed at nation building (under the slogan “one people - one nation". I attempt to show that liberal pluralist practice can be adapted to make space for cultural and ethnic categories, and that a nation of a common political identity can be constructed out of this adaptation, but that a re-interpretaiion of liberal notions of liberty and equality is required.

  12. Abortion Liberalization in World Society, 1960-2009.

    Science.gov (United States)

    Boyle, Elizabeth H; Kim, Minzee; Longhofer, Wesley

    2015-11-01

    Controversy sets abortion apart from other issues studied by world society theorists, who consider the tendency for policies institutionalized at the global level to diffuse across very different countries. The authors conduct an event history analysis of the spread (however limited) of abortion liberalization policies from 1960 to 2009. After identifying three dominant frames (a women's rights frame, a medical frame, and a religious, natural family frame), the authors find that indicators of a scientific, medical frame show consistent association with liberalization of policies specifying acceptable grounds for abortion. Women's leadership roles have a stronger and more consistent liberalizing effect than do countries' links to a global women's rights discourse. Somewhat different patterns emerge around the likelihood of adopting an additional policy, controlling for first policy adoption. Even as support for women's autonomy has grown globally, with respect to abortion liberalization, persistent, powerful frames compete at the global level, preventing robust policy diffusion.

  13. Abortion Liberalization in World Society, 1960-2009

    Science.gov (United States)

    Boyle, Elizabeth H.; Kim, Minzee; Longhofer, Wesley

    2015-01-01

    Controversy sets abortion apart from other issues studied by world society theorists, who consider the tendency for policies institutionalized at the global level to diffuse across very different countries. We conduct an event history analysis of the spread (however limited) of abortion liberalization policies from 1960 to 2009. After identifying three dominant frames (a women's rights frame, a medical frame, and a religious, natural family frame), we find that indicators of a scientific, medical frame show consistent association with liberalization of policies specifying acceptable grounds for abortion. Women's leadership roleshave a stronger and more consistent liberalizing effect than do countries' links to a global women's rights discourse. Somewhat different patterns emerge around the likelihood of adopting an additional policy, controlling for first policy adoption. Even as support for women's autonomy has grown globally, with respect to abortion liberalization, persistent, powerful frames compete at the global level, preventing robust policy diffusion. PMID:26900619

  14. Piero Gobetti and the Politics of Liberal Revolution

    OpenAIRE

    Martin, James

    2008-01-01

    Piero Gobetti was an astonishing figure. A radical liberal and fierce critic of Italian politics in the years after World War I, he was fascinated by the workers' struggles in his native Turin and by Gramsci's vision of a factory-based democracy. Gobetti proposed liberalism as an emancipatory theory grounded in social conflicts. "Revolutionary liberalism," as he called it, guided his opposition to Fascism and, following his untimely death at twenty-five, inspired key figures in the Italian Re...

  15. Liberty Challenge or Dangers of Liberal Democracy

    Directory of Open Access Journals (Sweden)

    Dalia Eidukienė

    2011-03-01

    Full Text Available The article analyses dialectics of a modern democracy and liberalism through the new (from the quality point of view subsistence of liberty, the priority element of democracy, in liberal democracies. The significance of such discourse is determined by the existing social inequality and its conversion into political domain. Particular attention is paid to the social issue, which was treated by Max Weber already as the reason of death of the old, fanatic German “national liberalism”, since it has not managed to belong to the German environment. Even today, it still lies in the principles of life and reality of “young” democratic post­soviet states. Conversion of a social issue into political domain disorganises the society, and it is hardly capable to socialise its norms and values in order to be obligated with regard to civic goals. In other words, the social issue significantly adjusts the pace and direction of transformation of the society. Therefore, an immature “young” liberal democracy may become “less liberal” or no longer conform to the “strict” definition of liberal democracy. Referring to the above, we conclude that social composition should become the medium of political reconstruction for “young” democracies. This does not mean, however, the change of the genetic code of liberalism. This is a striving to vest it, as an ideology, additional powers for rationalisation of democracy by delivering to it the content and the meaning, which would answer the challenges and problems of the time. Liberalism should create a new, from the quality point of view, hierarchy of values and become a new context for both political thinking and democracy. This would render new impulses to economic and public politics, meanwhile developing new premises for a new, from the quality point of view, democracy that would help to consolidate the society for the becoming of liberal democracy.  

  16. How Liberal is Nepal's Liberal Grade Promotion Policy?

    OpenAIRE

    Sharma, Dhiraj

    2016-01-01

    This paper estimates the magnitude of liberal grade promotion in public schools in Nepal by comparing the pass rate in internally administered exams with the pass rate in the district-exam whose scores determine grade transition. The pass rate in the year-end exam is three and a half times as high as the pass rate in the internal exams. The difference is not explained by an increase in stu...

  17. Critical Studies, the Liberal Arts, and Journalism Education.

    Science.gov (United States)

    Parisi, Peter

    1992-01-01

    Discusses the relationship between journalism education and the liberal arts. Contends that critical, cultural, or qualitative studies provide a powerful focus for linking journalism education more firmly to the liberal arts. (SR)

  18. Political Liberalism, Linguistic Diversity and Equal Treatment

    Science.gov (United States)

    Bonotti, Matteo

    2017-01-01

    This article explores the implications of John Rawls' political liberalism for linguistic diversity and language policy, by focusing on the following question: what kind(s) of equality between speakers of different languages and with different linguistic identities should the state guarantee under political liberalism? The article makes three…

  19. Desert, Liberalism and Justice in Democratic Education

    Science.gov (United States)

    Jonsson, Olafur Pall

    2012-01-01

    Liberal democratic education, as advocated in recent accounts of citizenship education or civic education, is often seen as incompatible with moral education or character education rooted in specific views regarding the virtues. This contrast relies on well established philosophical differences between liberal views of justice and democracy, on…

  20. New potentially antihypertensive peptides liberated in milk during fermentation with selected lactic acid bacteria and kombucha cultures.

    Science.gov (United States)

    Elkhtab, Ebrahim; El-Alfy, Mohamed; Shenana, Mohamed; Mohamed, Abdelaty; Yousef, Ahmed E

    2017-12-01

    Compounds with the ability to inhibit angiotensin-converting enzyme (ACE) are used medically to treat human hypertension. The presence of such compounds naturally in food is potentially useful for treating the disease state. The goal of this study was to screen lactic acid bacteria, including species commonly used as dairy starter cultures, for the ability to produce new potent ACE-inhibiting peptides during milk fermentation. Strains of Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus delbrueckii ssp. bulgaricus, Lactobacillus helveticus, Lactobacillus paracasei, Lactococcus lactis, Leuconostoc mesenteroides, and Pediococcus acidilactici were tested in this study. Additionally, a symbiotic consortium of yeast and bacteria, used commercially to produce kombucha tea, was tested. Commercially sterile milk was inoculated with lactic acid bacteria strains and kombucha culture and incubated at 37°C for up to 72 h, and the liberation of ACE-inhibiting compounds during fermentation was monitored. Fermented milk was centrifuged and the supernatant (crude extract) was subjected to ultrafiltration using 3- and 10-kDa cut-off filters. Crude and ultrafiltered extracts were tested for ACE-inhibitory activity. The 10-kDa filtrate resulting from L. casei ATCC 7469 and kombucha culture fermentations (72 h) showed the highest ACE-inhibitory activity. Two-step purification of these filtrates was done using HPLC equipped with a reverse-phase column. Analysis of HPLC-purified fractions by liquid chromatography-mass spectrometry/mass spectrometry identified several new peptides with potent ACE-inhibitory activities. Some of these peptides were synthesized, and their ACE-inhibitory activities were confirmed. Use of organisms producing these unique peptides in food fermentations could contribute positively to human health. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  1. Teaching for Toleration in Pluralist Liberal Democracies

    Science.gov (United States)

    van Waarden, Betto

    2017-01-01

    This article determines which education enables the perpetuation of diverse ways of life and the liberal democracy that accommodates this diversity. Liberals like John Rawls, Stephen Macedo, and William Galston have disagreed about the scope of civic education. Based on an analysis of toleration--the primary means for maintaining a pluralist…

  2. The Manners of Liberalism: A Question of Limits.

    Science.gov (United States)

    Allen, William B.

    1982-01-01

    The argument that liberal education leads people to substitute intellectual tolerance or ambiguity for righteous indignation is criticized, with reference to Harriet Beecher Stowe's portrayal of Thomas Jefferson, his liberalism, and democratic manners. (MSE)

  3. Synthesis, cytotoxicity, cellular uptake and influence on eicosanoid metabolism of cobalt-alkyne modified fructoses in comparison to auranofin and the cytotoxic COX inhibitor Co-ASS.

    Science.gov (United States)

    Ott, Ingo; Koch, Thao; Shorafa, Hashem; Bai, Zhenlin; Poeckel, Daniel; Steinhilber, Dieter; Gust, Ronald

    2005-06-21

    Propargylhexacarbonyldicobalt complexes with fructopyranose ligands were prepared and investigated for cytotoxicity in the MCF-7 human breast cancer cell line. The antiproliferative effects depended on the presence of isopropylidene protecting groups in the carbohydrate ligand and correlated with the cellular concentration of the complexes. IC(50) values of > 20 microM demonstrated that the fructose derivatives were only moderately active compared to the references auranofin and the aspirin (ASS) derivative [2-acetoxy(2-propynyl)benzoate]hexacarbonyldicobalt (Co-ASS). In continuation of our studies on the mode of action of cobalt-alkyne complexes we studied the influence of the compounds on the formation of 12-HHT (COX-1 product) and 12-HETE (12-LOX product) by human platelets as an indication of the interference in the eicosanoid metabolism, which is discussed as a target system of cytostatics. Co-ASS was an efficient COX-1 inhibitor without LOX inhibitory activity and auranofin inhibited both COX-1 and 12-LOX eicosanoid production. The missing activity of the fructopyranose complexes at the 12-LOX and the only moderate effects at COX-1 indicate that COX/LOX inhibition may be in part responsible for the pharmacological effects of auranofin and Co-ASS but not for those of the fructopyranose complexes.

  4. Effects of omega-3 fatty acid supplementation on the pattern of oxylipins: a short review about the modulation of hydroxy-, dihydroxy-, and epoxy-fatty acids.

    Science.gov (United States)

    Ostermann, Annika I; Schebb, Nils Helge

    2017-07-19

    A growing body of evidence suggests that the intake of the long chain omega-3 polyunsaturated fatty acids (n3-PUFA) eicosapentaenoic acid (C20:5 n3, EPA) and docosahexaenoic acid (C22:6 n3, DHA) is linked to beneficial health effects, particularly in the prevention of cardiovascular and inflammatory diseases. Although the molecular mode of action of n3-PUFA is still not fully understood, it is not controversial that a significant portion of the (patho)-physiological effects of PUFA are mediated by their oxidative metabolites, i.e. eicosanoids and other oxylipins. Quantitative targeted oxylipin methods allow the comprehensive monitoring of n3-PUFA supplementation induced changes in the pattern of oxylipins in order to understand their biology. In this short review, results from intervention studies are summarized analyzing >30 oxylipins from different PUFAs in response to n3-PUFA supplementation. The results are not only qualitatively compared with respect to the study design, n3-PUFA dose and trends in the lipid mediators, but also quantitatively based on the relative change in the oxylipin level induced by n3-PUFA. The evaluation of the data from the studies shows that the change in oxylipins generally corresponded to the observed changes in their precursor PUFA, i.e. the lower the individual n3-status at the baseline, the higher the increase in EPA and DHA derived oxylipins. The strongest relative increases were found for EPA derived oxylipins, while changes in arachidonic acid (C20:4 n6, ARA) derived eicosanoids were heterogeneous. After 3-12 weeks of supplementation, similar relative changes were observed in free and total (free + esterified) oxylipins in plasma and serum. Regarding EPA derived oxylipins, the results indicate a trend for a linear increase with dose. However, the interpretation of the quantitative oxylipin patterns between studies is hampered by strong inter-individual variances in oxylipin levels between and also within the studies. In the

  5. Child Labor and Trade Liberalization in Indonesia

    Science.gov (United States)

    Kis-Katos, Krisztina; Sparrow, Robert

    2011-01-01

    We examine the effects of trade liberalization on child work in Indonesia, identifying geographical differences in the effects of trade policy through district level exposure to reduction in import tariff barriers, from 1993 to 2002. The results suggest that increased exposure to trade liberalization is associated with a decrease in child work…

  6. Enlightening Global Communication: Liberation Philosophy and the ...

    African Journals Online (AJOL)

    Based on historical records the second half of the twentieth century can be marked as a point of departure for a substantial movement on the topic of liberation across the world; liberation which is contained within a contentious critical popular voice of change on the prevailing and broad political structure of the world.

  7. Fay Weldon, liberal feminism and the praxis of Praxis

    Directory of Open Access Journals (Sweden)

    A. Foley

    2007-07-01

    Full Text Available This article focuses on Fay Weldon’s novel, “Praxis”, as a means of exploring the concept of “liberal feminism”. “Praxis” charts the development of the eponymous main protagonist from a woman complicit in her own patriarchal oppression to a radical feminist activist and finally to the point where she comes to a liberal realisation of the nuances of individual women’s experiences and the complexity of emancipation. The novel may be regarded as a liberal feminist text in its emphasis on both gender equality and individual liberty, and in its insistence that society may be positively reformed within the paradigm of the liberal state and without resorting to radical extremism. Published in 1978, the novel anticipates the later shift in feminist thinking from an exclusive concern with women’s rights to a more inclusive liberal vision of human rights.

  8. Intergovernmental approach of the new liberalism in the development of integration processes

    OpenAIRE

    O. P. Stadnyk; R. Y. Romaniuk

    2013-01-01

    Investigated intergovernmental theory approach to understanding the new liberalism integration processes. Determined the nature of the liberal intergovernmental approach that Andrew Moravchik developed within the new liberalism. Emphasized that the intergovernmental approach of the new liberalism theory considers national preferences in international relations as being primarily determined by domestic political processes. Liberal intergovernmental approach rejects the rhetoric of so­called na...

  9. The Liberal Arts College and Humanist Learning

    Science.gov (United States)

    Arcilla, René V.

    2014-01-01

    What is liberal education? How do its aims differ from those of either grammar or vocational education? Does it truly deserve its own supporting institution? In response to these questions, Arcilla develops a defense of the liberal arts college. He observes that all projects of formal learning presuppose that the learner possesses answers to three…

  10. Iris Murdoch, Liberal Education and Human Flourishing

    Science.gov (United States)

    Evans, William

    2009-01-01

    Articulating the good of liberal education--what we should teach and why we should teach it--is necessary to resist the subversion of liberal education to economic or political ends and the mania for measurable skills. I argue that Iris Murdoch's philosophical writings enrich the work of contemporary Aristotelians, such as Joseph Dunne and…

  11. Intergovernmental approach of the new liberalism in the development of integration processes

    Directory of Open Access Journals (Sweden)

    O. P. Stadnyk

    2013-12-01

    Full Text Available Investigated intergovernmental theory approach to understanding the new liberalism integration processes. Determined the nature of the liberal intergovernmental approach that Andrew Moravchik developed within the new liberalism. Emphasized that the intergovernmental approach of the new liberalism theory considers national preferences in international relations as being primarily determined by domestic political processes. Liberal intergovernmental approach rejects the rhetoric of so­called national interests and instead focuses on interest groups that define a specific government policy regarding foreign partners. Specified on crucial economic lobbying pressure defined interest groups in the formation of national preferences. The features considering interest groups that determine foreign policy under the intergovernmental approach a theory of new liberalism. Singled out a number of critical approaches to the liberal intergovernmental approach given the nature explanation integration processes. Clarified the value of the intergovernmental approach within theories of political integration by taking into account the theoretical and conceptual foundations of his liberal variety ­ liberal intergovernmental approach as part of a new theory of liberalism, which involves the formation of national preferences in international relations through domestic contexts interaction of national interest groups and their lobbying pressure.

  12. Multiculturalism and the Liberal Arts College: Faculty Perceptions of Pedagogy.

    Science.gov (United States)

    Aleman, Ana M. Martinez; Salkever, Katya

    This is a qualitative study of faculty perceptions of the relationship between pedagogy, liberal education, and multiculturalism. The incompatibility of liberal education and multiculturalism ground this study along with the assertion that teaching and learning are central to the liberal education mission. Nineteen faculty members participated in…

  13. Mission, Multiculturalism, and the Liberal Arts College: A Qualitative Investigation.

    Science.gov (United States)

    Aleman, Ana M. Martinez; Salkever, Katya

    2003-01-01

    Using qualitative methods, explored how faculty, administrators, and students at a liberal arts college understand the mission of liberal education and its relationship to their institutional goals for multicultural community. Interview data suggest that the traditional liberal educational mission of this college thwarts the development of…

  14. Liberal luxury: Decentering Snowden, surveillance and privilege

    Directory of Open Access Journals (Sweden)

    Piro Rexhepi

    2016-11-01

    Full Text Available This paper reflects on the continued potency of veillance theories to traverse beyond the taxonomies of surveillance inside liberal democracies. It provides a commentary on the ability of sousveillance to destabilise and disrupt suer/violence by shifting its focus from the centre to the periphery, where Big Data surveillance is tantamount to sur/violence. In these peripheral political spaces, surveillance is not framed by concerns over privacy, democracy and civil society; rather, it is a matter of life and death, a technique of both biopolitical and thanatopolitical power. I argue that the universalist, and universalizing, debates over surveillance cannot be mapped through the anxieties of privileged middle classes as they would neither transcend nor make possible alternative ways of tackling the intersection of surveillance and violence so long as they are couched in the liberal concerns for democracy. I call this phenomenon “liberal luxury,” whereby debates over surveillance have over-emphasised liberal proclivities at the expense of disengaging those peripheral populations most severely affected by sur/violence.

  15. From Liberal Democracy to the Cosmopolitan Canopy

    Directory of Open Access Journals (Sweden)

    Jon Van Til

    2015-03-01

    Full Text Available Liberalism is that ideology, that worldview, which values, in an ever-evolving set of intelligently intermingled thoughts:  democracy, freedom (liberty, equality (justice, fraternity (solidarity, the pursuit of happiness, pluralism (diversity, and human rights--and explores the ever-open ever-possible futures of their rediscovery and advance. The study of ways in which social movements relate to Third sector/nonprofit or voluntary organizations can be structured, if we choose, as a liberal endeavor.  That is the message I receive from Antonin Wagner’s (2012 telling of the emergence of a field that focuses its study and developmental energies on place of intermediate associational life in modern society, from Adalbert Evers’ efforts to sustain the welfare state in an era of untrammeled capitalism (2013, and from Roger Lohmann’s (1992 comprehensive vision of a social commons capable of assuring the values of liberal society. This paper sets the theory of liberal democracy in a contemporary cosmopolitan context, drawing on case material from Hungary, Northern Ireland,  and the United States.

  16. Legal Education, Liberal Education, and the Trivial "Artes."

    Science.gov (United States)

    Kimball, Bruce A.

    1986-01-01

    Reviews the influence of liberal education upon legal education, studying the historical process according to which changes of emphasis within liberal education (from rhetoric to dialectic or the reverse) have been reflected in related changes in legal education. (AYC)

  17. The Morphing of America's Liberal Arts Colleges

    Science.gov (United States)

    DiMaria, Frank

    2010-01-01

    In this article, the author discusses the paper, "Where Are They Now? Revisiting Breneman's Study of Liberal Arts Colleges" by Vicki L. Baker, assistant professor at Albion College and Roger G. Baldwin, professor at University of Michigan. Their paper takes a look back at David W. Breneman's study "Are We Losing Our Liberal Arts Colleges?" and it…

  18. Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin.

    Science.gov (United States)

    Suban, Dejan; Zajc, Tajana; Renko, Miha; Turk, Boris; Turk, Vito; Dolenc, Iztok

    2012-03-01

    The release of a thyroid hormone from thyroglobulin is controlled by a complex regulatory system. We focused on the extracellular action of two lysosomal enzymes, cathepsin C (catC, dipeptidyl peptidase I) and PGCP (lysosomal dipeptidase), on thyroglobulin, and their ability to liberate the hormone thyroxin. Cathepsin C, an exopeptidase, removes dipeptides from the N-terminus of substrates, and PGCP hydrolyses dipeptides to amino acids. In vitro experiments proved that cathepsin C removes up to 12 amino acids from the N-terminus of porcine thyroglobulin, including a dipeptide with thyroxin on position 5. The newly formed N-terminus, Arg-Pro-, was not hydrolysed further by cathepsin C. Cell culture experiments with FRTL-5 cell line showed localization of cathepsin C and PGCP and their secretion into the medium. Secretion of the active cathepsin C from FRTL-5 cells is stimulated by TSH, insulin, and/or somatostatin. The released enzymes liberate thyroxin from porcine thyroglobulin added to media. The hormone liberation can be reduced by synthetic inhibitors of cysteine proteinases and metalloproteinases. Additionally, we show that TSH, insulin, and/or somatostatin induce up-regulation of N-acetylglucosaminyltransferase 1, the enzyme responsible for the initiation of biosynthesis of hybrid and complex N-glycosylation of proteins. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  19. Issues and prospects of digitizing liberation movements' archives ...

    African Journals Online (AJOL)

    User

    collective memory. Keywords: digitization,. NAHECS, liberation archives, digitally born, audio- visual. Introduction and background to liberation archives. Archives are generally records of .... long term preservation and access to selected archival materials ..... by International Library of African Music. (ILAM) in. Rhodes.

  20. A new model to study the role of arachidonic acid in colon cancer pathophysiology

    Science.gov (United States)

    Fan, Yang-Yi; Callaway, Evelyn; Monk, Jennifer M.; Goldsby, Jennifer S.; Yang, Peiying; Vincent, Logan; Chapkin, Robert S.

    2016-01-01

    A significant increase in cyclooxygenase 2 (COX2) gene expression has been shown to promote cylcooxygenase-dependent colon cancer development. Controversy associated with the role of COX2 inhibitors indicates that additional work is needed to elucidate the effects of arachidonic acid (AA) derived (cyclooxygenase and lipoxygenase) eicosanoids in cancer initiation, progression and metastasis. We have recently developed a novel Fads1 knockout mouse model, which allows for the investigation of AA-dependent eicosanoid deficiency without the complication of essential fatty acid deficiency. Interestingly, the survival rate of Fads1 null mice is severely compromised after 2 months on a semi-purified AA-free diet, which precludes long-term chemoprevention studies. Therefore, in this study, dietary AA levels were titrated to determine the minimal level required for survival, while maintaining a distinct AA-deficient phenotype. Null mice supplemented with AA (0.1, 0.4, 0.6, 2.0%, w/w) in the diet exhibited a dose-dependent increase (P diet were injected with a colon-specific carcinogen (azoxymethane) in order to assess cancer susceptibility. Null mice exhibited significantly (P < 0.05) reduced levels/multiplicity of aberrant crypt foci (ACF) as compared to wild type sibling littermate control mice. These data indicate that (i) basal/minimal dietary AA supplementation (0.6%) expands the utility of the Fads1 Null mouse model for long-term cancer prevention studies, and (ii) that AA content in the colonic epithelium modulates colon cancer risk. PMID:27339171

  1. Political regime change, economic liberalization and growth accelerations

    NARCIS (Netherlands)

    Jong-A-Pin, Richard; De Haan, Jakob

    We examine whether the type of political regime, regime changes, and economic liberalization are related to economic growth accelerations. Our results show that growth accelerations are preceded by economic liberalizations. We also find that growth accelerations are less likely to happen the longer

  2. Liberals think more analytically (more "WEIRD") than conservatives.

    Science.gov (United States)

    Talhelm, Thomas; Haidt, Jonathan; Oishi, Shigehiro; Zhang, Xuemin; Miao, Felicity F; Chen, Shimin

    2015-02-01

    Henrich, Heine, and Norenzayan summarized cultural differences in psychology and argued that people from one particular culture are outliers: people from societies that are Western, educated, industrialized, rich, and democratic (WEIRD). This study shows that liberals think WEIRDer than conservatives. In five studies with more than 5,000 participants, we found that liberals think more analytically (an element of WEIRD thought) than moderates and conservatives. Study 3 replicates this finding in the very different political culture of China, although it held only for people in more modernized urban centers. These results suggest that liberals and conservatives in the same country think as if they were from different cultures. Studies 4 to 5 show that briefly training people to think analytically causes them to form more liberal opinions, whereas training them to think holistically causes shifts to more conservative opinions. © 2014 by the Society for Personality and Social Psychology, Inc.

  3. States of Liberation

    DEFF Research Database (Denmark)

    Sen, Somdeep

    in the context of the Palestinian quest for liberation. Based on ethnographic fieldwork in the Gaza Strip, the West Bank, Israel and Egypt, this dissertation argues that resistance and governance serve as means of emboldening the signature of Palestinian existence – as a cause and as a people. Hamas’ resistance...

  4. Deliberative Democracy between Social Liberalism and Neoliberalism

    DEFF Research Database (Denmark)

    Loftager, Jørn

    During the same decades as neoliberalism has expanded at the expense of social liberalism, democratic theory has witnessed a profound deliberative turn. The paper explores links be-tween these developments and presents a double argument. First, it argues for a critical oppo-sition between a current...... agenda with problems calling for effective public reasoning and the predominance of neoliberal politics and ideas of citizenship. Whereas a social liberal notion of citizenship based on equal rights is conducive to deliberative democracy, recent years’ ne-oliberalism tends to define citizenship in terms...... in neoliberal ontology (Hayek). Here there is a remarkable parallel to French solidarism and especially the social liberal think-ing of Durkheim. Danish politics will serve as an illustrative empirical, least likely, case in point....

  5. Resolution of Toll-like receptor 4-mediated acute lung injury is linked to eicosanoids and suppressor of cytokine signaling 3.

    Science.gov (United States)

    Hilberath, Jan N; Carlo, Troy; Pfeffer, Michael A; Croze, Roxanne H; Hastrup, Frantz; Levy, Bruce D

    2011-06-01

    The purpose of this study was to investigate roles for Toll-like receptor 4 (TLR4) in host responses to sterile tissue injury. Hydrochloric acid was instilled into the left mainstem bronchus of TLR4-defective (both C3H/HeJ and congenic C.C3-Tlr4(Lps-d)/J) and control mice to initiate mild, self-limited acute lung injury (ALI). Outcome measures included respiratory mechanics, barrier integrity, leukocyte accumulation, and levels of select soluble mediators. TLR4-defective mice were more resistant to ALI, with significantly decreased perturbations in lung elastance and resistance, resulting in faster resolution of these parameters [resolution interval (R(i)); ∼6 vs. 12 h]. Vascular permeability changes and oxidative stress were also decreased in injured HeJ mice. These TLR4-defective mice paradoxically displayed increased lung neutrophils [(HeJ) 24×10(3) vs. (control) 13×10(3) cells/bronchoalveolar lavage]. Proresolving mechanisms for TLR4-defective animals included decreased eicosanoid biosynthesis, including cysteinyl leukotrienes (80% mean decrease) that mediated CysLT1 receptor-dependent vascular permeability changes; and induction of lung suppressor of cytokine signaling 3 (SOCS3) expression that decreased TLR4-driven oxidative stress. Together, these findings indicate pivotal roles for TLR4 in promoting sterile ALI and suggest downstream provocative roles for cysteinyl leukotrienes and protective roles for SOCS3 in the intensity and duration of host responses to ALI.

  6. LIBER MARC Harmonization Task Force - Format activities in European countries

    Directory of Open Access Journals (Sweden)

    Renate Gömpel

    2004-03-01

    Full Text Available The LIBER MARC Harmonization Task Force has its origins in an initiative of the past President of LIBER, Professor Elmar Mittler from the Göttingen State and University Library. Professor Mittler asked Dr Elisabeth Niggemann from Die Deutsche Bibliothek to take part in the meeting of the MARC Harmonization Coordinating Committee in Ottawa in May 2001. Following that meeting the LIBER MARC Harmonization Task Force was founded at the LIBER Annual Conference in July 2001 in London. The LIBER MARC Harmonization Task Force held its first meeting on 14 January 2002 at Die Deutsche Bibliothek Frankfurt am Main, with the aim of gaining an overview of format activities in Europe. The group's aim was to concentrate on European developments and to build up stronger cooperation in the library world in order to strengthen Europe's international influence. The LIBER MARC Harmonization Task Force held a second meeting at the IFLA 2002 Conference in Glasgow and discussed the first draft of its report and recommendations to LIBER. After final discussion within the group, this report has been further revised and was submitted to LIBER. The aim of the report is to give an overview of format activities in European countries and to make recommendations to LIBER regarding the use and development of data formats in Europe. The annex includes reports on migration activities from different countries. The report is based on information on data formats collected and compiled on the basis of a questionnaire distributed to the Conference of European National Librarians (CENL. Cataloguing issues were further discussed at the 1st IFLA Meeting of Experts on an International Cataloguing Code held in Frankfurt in July 2003. Further meetings will be held at the IFLA conferences in Buenos Aires (2004 and Seoul (2006.

  7. Liberalism and African Culture.

    Science.gov (United States)

    Sindima, Harvey

    1990-01-01

    Discusses the effect of liberalism on the African understanding of education, community, and religion. Describes ways in which the European intrusion, that is, colonial governments, schools, and churches, undermined traditional African life and thought. (DM)

  8. Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors.

    Science.gov (United States)

    Comba, Andrea; Lin, Yi-Hui; Eynard, Aldo Renato; Valentich, Mirta Ana; Fernandez-Zapico, Martín Ernesto; Pasqualini, Marìa Eugenia

    2011-12-01

    This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism.

  9. Defending perfectionism: Some comments on Quong’s liberalism without perfection

    Directory of Open Access Journals (Sweden)

    Kulenović Enes

    2014-01-01

    Full Text Available The article offers a defense of liberal perfectionism in the light of criticism of perfectionist politics stated in Jonathan Quong’s book Liberalism without Perfection. It argues against Quong’s claims that perfectionism is incompatible with demands of individual autonomy and non-paternalism as requirements of liberal commitment of treating all persons as free and equal.

  10. Decolonizing Liberation: Toward a Transnational Feminist Psychology

    Directory of Open Access Journals (Sweden)

    Tuğçe Kurtiş

    2015-08-01

    Full Text Available This paper engages the theme of “decolonizing psychological science” in the context of a perspective on psychological theory and research—namely, feminist psychology—that shares an emphasis on broad liberation. Although conceived as a universal theory and practice of liberation, scholars across diverse sites have suggested that feminism—perhaps especially as it manifests in psychological science—is not always compatible with and at times is even contradictory to global struggles for decolonization. The liberatory impulse of feminist psychology falls short of its potential not only because of its grounding in neocolonial legacies of hegemonic feminisms, but also because of its complicity with neocolonial tendencies of hegemonic psychological science. In response to these concerns, we draw upon on perspectives of transnational feminisms and cultural psychology as tools to decolonize (feminist psychology. We then propose the possibility of a (transnational feminist psychology that takes the epistemological position of people in various marginalized majority-world settings as a resource to rethink conventional scientific wisdom and liberate “liberation”. Rather than freeing some women to better participate in global domination, a transnational feminist psychology illuminates sustainable ways of being that are consistent with broader liberation of humanity in general.

  11. Economic Liberalization and Political Violence : Utopia or Dystopia ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-08-06

    Economic Liberalization and Political Violence : Utopia or Dystopia ? Couverture du livre Economic Liberalization and Political Violence : Utopia or Dystopia ? Editor(s):. Francisco Gutiérrez et Gerd Schönwälder. Publisher(s):. Pluto Press, CRDI. August 6, 2010. ISBN: 9780745330631. 360 pages. e-ISBN: 9781552504826.

  12. Liberal coercion? Prostitution, human trafficking and policy

    OpenAIRE

    Cho, Seo-young

    2013-01-01

    Liberal prostitution policy aims at improving labour conditions for prostitutes and protecting victims of forced prostitution. Its policy orientation predicts that the policy choice of liberalizing prostitution is positively associated with better protection policy for trafficking victims and enhanced anti-trafficking measures. In this paper, I investigate empirically whether the legalization of prostitution improves protection policy for victims, as it is presumed. The results of my analysis...

  13. Decentralized energy supply on the liberalized market

    International Nuclear Information System (INIS)

    Pauli, H.

    1999-01-01

    Starting in 2001, the electricity market is to be progressively liberalized. The process will be completed by the year 2006. What role will decentralized power generation using combined cycle power plants play on a liberalized market ? The background conditions are essentially favourable: both the new energy act, which has been in force since 1 January 1999, and the planned energy levy suggest that this technology will become increasingly widespread. In addition, the price trend for combined cycle plants components together with low energy costs are having a favourable impact. On the other hand, great uncertainty is being created by the process of liberalization and the current flood of investments in power generation. However, electricity supply is unlikely to be in surplus for long in a context of sustained economic growth. (author)

  14. Fiscal Policy Problems Under Conditions Of Financial Liberalization

    Directory of Open Access Journals (Sweden)

    Valentina Urazayeva

    2014-01-01

    Full Text Available The article under the title deals with the difficulties in pursuing national fiscal policy in conditions of international financial liberalization. The author analyzes the nature of liberalization of international capital flows and its positive and negative consequences for the economies of the countries which participate in global capital movement. The author especially highlights the fact that international financial liberalization often leads to economic crises and what is even more important to their rapid spread between countries due to their growing financial interdependence. The author distinguishes two groups of fiscal policy problems in conditions of international financial liberalization. The first group includes problems arising due to quick spread of the crises due to eliminating restrictions on crossborder capital flows. These are reduction in taxes and at the same time increase in budget spending, which often happens unexpectedly and substantially impedes fiscal policy. To illustrate these points the author refers to the statistics on Spain, the USA and the OECD as a whole. Moreover countries face another range of problems regardless of the business cycle phase. In the short term it is the necessity of large scale structural economic reforms to achieve the required level of financial liberalization, which often is a heavy burden on the state budget. In the long term the attention is paid to the problem of tax competition between countries, which affects the instruments of fiscal policy. The author notes that the negative consequences of global financial liberalization are relevant not only for recipient countries but for donor countries as well and emphasizes such a burning issue as "capital flight".

  15. FISCAL POLICY PROBLEMS UNDER CONDITIONS OF FINANCIAL LIBERALIZATION

    Directory of Open Access Journals (Sweden)

    Valentina Urazayeva

    2014-01-01

    Full Text Available The article under the title deals with the difficulties in pursuing national fiscal policy in conditions of international financial liberalization. The author analyzes the nature of liberalization of international capital flows and its positive and negative consequences for the economies of the countries which participate in global capital movement. The author especially highlights the fact that international financial liberalization often leads to economic crises and what is even more important to their rapid spread between countries due to their growing financial interdependence. The author distinguishes two groups of fiscal policy problems in conditions of international financial liberalization. The first group includes problems arising due to quick spread of the crises due to eliminating restrictions on crossborder capital flows. These are reduction in taxes and at the same time increase in budget spending, which often happens unexpectedly and substantially impedes fiscal policy. To illustrate these points the author refers to the statistics on Spain, the USA and the OECD as a whole. Moreover countries face another range of problems regardless of the business cycle phase. In the short term it is the necessity of large scale structural economic reforms to achieve the required level of financial liberalization, which often is a heavy burden on the state budget. In the long term the attention is paid to the problem of tax competition between countries, which affects the instruments of fiscal policy. The author notes that the negative consequences of global financial liberalization are relevant not only for recipient countries but for donor countries as well and emphasizes such a burning issue as "capital flight".

  16. Faithful obligations: Merold Westphal’s middle class liberation theology

    OpenAIRE

    Justin Sands

    2016-01-01

    Often, liberation theology’s preferential option for the poor is pushed aside within theological discourses as being too specific, too focused on social problems, to function as a viable theology for the Church as a whole. Through this line of reasoning, many often see liberation theology as something that can remind Christians of their need to help others, but it cannot become the foundation for a sustainable belief system. In response to this, I claim that a liberation theology can be viabl...

  17. Liberalism in India-Pakistan Relations: a critique of realism

    OpenAIRE

    MEHSUD, Muhammad Imran

    2017-01-01

    Liberalism is increasingly applied in explaining post-Cold War India-Pakistan relations. It is argued that both the nations have cultivated liberal values, resulting in complex interdependence and peace in their mutual relationship. The existence of different regimes as the Indus Waters Treaty, regional trade regime of SAPTA and SAFTA, CBMs and gas regime of TAPI and IPI, are referred to as liberal trends in their IR. However, this article contends such a view as naïve and idealistic. India a...

  18. Genetics of the proteolytic system of lactic acid bacteria

    NARCIS (Netherlands)

    Kok, Jan

    1990-01-01

    The proteolytic system of lactic acid bacteria is of eminent importance for the rapid growth of these organisms in protein-rich media. The combined action of proteinases and peptidases provides the cell with small peptides and essential amino acids. The amino acids and peptides thus liberated have

  19. A GLANCE AT THE EUROPEAN ENERGY MARKET LIBERALIZATION

    Directory of Open Access Journals (Sweden)

    Delia Vasilica Rotaru

    2013-03-01

    Full Text Available This paper offers a presentation on the liberalization process on the energy markets that started two decades ago and takes place across Europe in the attempt to create a single European energy market. Several benefits are expected following the deregulation process such as higher competition, market transparency, lower prices, increased efficiency and product development in the clients favour. Three very different energy markets are analyzed before and after the liberalization process – UK, Germany and France – a short insight on the current Romanian energy market is also offered. The aim of this paper is to provide a better understanding on liberalizing European energy markets.

  20. Economic Liberalization and Political Violence : Utopia or Dystopia ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Economic Liberalization and Political Violence : Utopia or Dystopia ? Couverture du livre Economic Liberalization and Political Violence : Utopia or Dystopia ? Directeur(s):. Francisco Gutiérrez et Gerd Schönwälder. Maison(s) d'édition: Pluto Press, CRDI. 6 août 2010. ISBN : 9780745330631. 360 pages. e-ISBN :.

  1. Promoting Liberal Learning in a Capstone Accounting Course

    Science.gov (United States)

    Ahlawat, Sunita; Miller, Gerald; Shahid, Abdus

    2012-01-01

    This paper describes our efforts to integrate liberal learning principles in a capstone course within the overwhelmingly career-focused discipline of accountancy. Our approach was based on the belief that business and liberal learning courses are complementary, rather than competitive, elements of a well-rounded education. The ability to deal with…

  2. Right and Goods: Procedural Liberalism and Educational Policy

    Science.gov (United States)

    Johnston, James Scott

    2007-01-01

    In this essay, James Scott Johnston asks what sort of liberalism is best for the educational systems of early twenty-first century, late capitalistic democratic nations, looking at the procedural liberalism extant. Two major models are John Rawls's Justice as Fairness and Jurgen Habermas's Communicative Action. Both owe their foundational…

  3. Citizenship Education for Liberation in Nigeria | Ogunbiyi | Makerere ...

    African Journals Online (AJOL)

    Since the purpose of any functional education is to enlighten and liberate the beneficiaries, ensuring that they live a sustainable life while contributing meaningfully to the upkeep of their immediate community, this paper takes a look at citizenship liberation using qualitative civic education. It examines, inter alia, the aims and ...

  4. Liberal democracy and nuclear despotism: two ethical foreign policy dilemmas

    Directory of Open Access Journals (Sweden)

    Thomas E. Doyle

    2013-09-01

    Full Text Available This article advances a critical analysis of John Rawls's justification of liberal democratic nuclear deterrence in the post-Cold War era as found in The Law of Peoples. Rawls's justification overlooked how nuclear-armed liberal democracies are ensnared in two intransigent ethical dilemmas: one in which the mandate to secure liberal constitutionalism requires both the preservation and violation of important constitutional provisions in domestic affairs, and the other in which this same mandate requires both the preservation and violation of the liberal commitment to international legal arrangements and to the rule of law generally. On this view, the choice to violate constitutional provisions and international legal arrangements is evidence of nuclear despotism. Moreover, this choice does not imply that the ethical foreign policy dilemmas were resolved. Instead, it implies that the dilemmas force liberal democratic governments into implementing ethically paradoxical policy outcomes.

  5. Liberation of electric power and nuclear power generation

    International Nuclear Information System (INIS)

    Yajima, Masayuki

    2000-01-01

    In Japan, as the Rule on Electric Business was revised after an interval of 35 years in 1995, and a competitive bid on new electric source was adopted after 1996 fiscal year, investigation on further competition introduction to electric power market was begun by establishment of the Basic Group of the Electric Business Council in 1997. By a report proposed on January, 1999 by the Group, the Rule was revised again on March, 1999 to start a partial liberation or retail of the electric power from March, 2000. From a viewpoint of energy security and for solution of global environmental problem in Japan it has been decided to positively promote nuclear power in future. Therefore, it is necessary to investigate how the competition introduction affects to development of nuclear power generation and what is a market liberation model capable of harmonizing with the development on liberation of electric power market. Here was elucidated on effect of the introduction on previous and future nuclear power generation, after introducing new aspects of nuclear power problems and investigating characteristic points and investment risks specific to the nuclear power generation. And, by investigating some possibilities to development of nuclear power generation under liberation models of each market, an implication was shown on how to be future liberation on electric power market in Japan. (G.K.)

  6. Liberal Arts: Leadership Education in the 21st Century

    Science.gov (United States)

    Guthrie, Kathy L.; Callahan, Kathleen

    2016-01-01

    This chapter focuses on strategies and processes that integrate leadership learning across institutions. It discusses how leadership education fits a liberal education in various institutional types and operationalizes leadership and liberal arts curricula with five competencies.

  7. Radical, reformist and aborted liberalism: origins of national regimes in Central America

    Directory of Open Access Journals (Sweden)

    James MAHONEY

    2011-06-01

    Full Text Available During the twentieth century, the countries of Central America were characterized by remarkably different political regimes: military-authoritarianism in Guatemala and El Salvador, progressive democracy in Costa Rica and traditional-authoritarianism in Honduras and Nicaragua. This article explains these contrasting regime outcomes by exploring the agrarian and state-building reforms pursued by political leaders during the nineteenth– and early twentieth century liberal reform period. Based on differences in the transformation of state and class structures, three types of liberalism are identified: radical liberalism in Guatemala and El Salvador, reformist liberalism in Costa Rica and aborted liberalism in Honduras and Nicaragua. It is argued that these types of liberalism set the Central American countries on contrasting paths of political development, culminating in diverse regime outcomes.

  8. Christianity, development, and women's liberation.

    Science.gov (United States)

    Walker, B

    1999-03-01

    This paper explores the relationship between Christianity, development, and women's liberation. The article examines the opportunities and constraints, which exist for women in the tradition of mainstream Christianity regarding their sexuality and family life. These concepts were investigated within the community level, the church itself, convent life, in the economy, and at wider national and international levels. Subordination of women through religion is the result of imposing social codes regarding women's roles, behavior, and relationships with men. However, equality can be achieved if the forms and substance of religious practice is reexamined and changed with liberation of women in mind. There is also a need to address the cultural and spiritual imperialism brought about by religion.

  9. Liberalism in foreign trade versus liberalism in air transportation - is there a link?

    Directory of Open Access Journals (Sweden)

    Grancay Martin

    2014-01-01

    Full Text Available The aim of this paper is to determine whether there is a statistically significant link between regulation of international civil aviation and protectionism against foreign trade. We use weighted air liberalization index (WALI as a proxy for the level of regulation in a country’s foreign aviation relations; trade tariff restrictiveness index (TTRI and overall trade restrictiveness index (OTRI as proxies for the level of protectionism in a country’s foreign trade. Correlation analysis shows that there is no statistically significant link between the indicators. Hence, our research confirms the view that air transportation is a specific sector and it is subject to a different kind of policies than trade in goods. We also demonstrate that large high-income countries tend to have a more liberal approach to international civil aviation than small low-income countries.

  10. Prospects and Limits of Online Liberal Arts Education

    Science.gov (United States)

    Einfeld, Aaron

    2018-01-01

    For centuries, educators and philosophers have explored the benefits that a broad liberal education can offer to individuals and societies. More recently, prominent educational leaders have continued to articulate the value of a liberal education in the digital age. In this article, the author presents the prospects and limits of online liberal…

  11. Big Data and the Liberal Conception of Education

    Science.gov (United States)

    Clayton, Matthew; Halliday, Daniel

    2017-01-01

    This article develops a perspective on big data in education, drawing on a broadly liberal conception of education's primary purpose. We focus especially on the rise of so-called learning analytics and the associated rise of digitization, which we evaluate according to the liberal view that education should seek to cultivate individuality and…

  12. Artes Illiberales? The Four Myths of Liberal Education

    Science.gov (United States)

    O'Sullivan, Maurice

    2009-01-01

    The phrase "liberal education" has begun obliterating more precise and meaningful terms. At first the author assumed that in using it, those public intellectuals who regularly gather to redefine higher education or set benchmarks for it had merely found an abbreviated way of describing a liberal-arts education. After Jeffrey Nesteruk took the…

  13. Liberation as a Paradigm for Full Humanity in Africa

    Directory of Open Access Journals (Sweden)

    Tshuma Ephraim

    2016-06-01

    Full Text Available The study is a response to the call for papers that focuses on African issues and discusses the issue of liberation. This paper seeks to explore the theme of liberation beginning with its definition. It will then proceed by looking at the history of Israel discussing the Egyptian bondage. The identity and role of Moses will also be explored in light of the prominent role that the Hebrew Bible gives him in the exodus motifs. It also highlights the life and role of Jesus of Nazareth in human liberation. In addition it will also highlight the importance of liberation and will pay attention to the fight for freedom and independence in Africa. Finally it looks at the quest for liberation among marginalized women and children in Africa looking at their struggles in the 21st century. The essay will use examples from both theological and secular sources. The Biblical/theological examples will be drawn from the Hebrew Bible, the New Testament and commentaries. Since Africa is very big although sharing related issues, I will use specific examples from Zimbabwe and also use general information from across the continent.

  14. Liberalization of energy markets

    International Nuclear Information System (INIS)

    2004-01-01

    During the last decade, the supply of electricity has been liberalized in the Nordic countries - first in Norway in 1991 and most recently in Iceland in 2003. After the liberalization process the consumers can freely choose the end-use supplier that offers the most attractive prices and conditions of supply. This development has opened up new opportunities for the consumer, but has also created new problems. The amount of kWh consumed and the composition of the electricity price determines the extent to which a consumer can influence annual expenses by being active on the market. After liberalization the consumer price is composed of: The market price for electricity; Transmission tariffs; Consumer and energy taxes. Only the market price can be influenced by an active consumer. Most consumer problems are a result of the system with indirect metering that was introduced to make it costless for small consumers to change supplier. An individual consumer's consumption is calculated according to the average consumption profile for all small consumers in the local distribution area and not according to her actual consumption. As metering is only taking place with intervals of one to several years many consumers have received invoices with large additional payments. Complaints are also common against distribution companies that have taken too long time to transfer the necessary information to the suppliers or have done it wrongly. The right solution would be to introduce intelligent meters that, in addition, could provide the consumers with new opportunities to monitor their electricity consumption. Such initiatives are now taking place in all four countries but it will take some years to provide intelligent meters to all consumers. Liberalization has caused an increasing number of consumer complaints. However, it has become less transparent to whom the complaint should be directed. When is it the distribution company and when the end-use supplier? This problem continues

  15. Liberalism Lost in Translation

    DEFF Research Database (Denmark)

    Philipsen, Lise

    2013-01-01

    undermine its liberal pretences. This is revealed in everyday practices of peacebuilding, where the concepts of accountability and ownership are reworked and given new meanings. In this process of re-signification, “accountability” becomes accountability towards the donors, and “ownership” a guise...

  16. Education Policy as Proto-Fascism: The Aesthetics of Racial Neo-Liberalism

    Science.gov (United States)

    Webb, P. Taylor; Gulson, Kalervo N.

    2011-01-01

    We argue that neo-liberal educational policy has emerged as a proto-fascist governmentality. This contemporary technology relies on State racisms and racial orderings manifested from earlier liberal and neo-liberal practices of biopower. As a proto-fascist technology, education policy, and school choice policies in particular, operate within a…

  17. Decolonizing Liberation: Toward a Transnational Feminist Psychology

    OpenAIRE

    Tuğçe Kurtiş; Glenn Adams

    2015-01-01

    This paper engages the theme of “decolonizing psychological science” in the context of a perspective on psychological theory and research—namely, feminist psychology—that shares an emphasis on broad liberation. Although conceived as a universal theory and practice of liberation, scholars across diverse sites have suggested that feminism—perhaps especially as it manifests in psychological science—is not always compatible with and at times is even contradictory to global struggles for decoloniz...

  18. Services Trade: Past Liberalization and Future Challenges

    OpenAIRE

    Gary Hufbauer; Sherry Stephenson

    2007-01-01

    Services trade has truly become an engine of world growth. Over the past two decades, international trade in services has grown faster than world merchandize trade, which in turn has grown faster than world output. A combination of policy liberalization and technological progress has facilitated trade in many previously untradable services. However, very little progress has been made towards new policy liberalization in the ongoing Doha Development Round. This article discusses trade in servi...

  19. 21st-century liberal democracy and its contradictions

    Directory of Open Access Journals (Sweden)

    Paolo Bellini

    2014-07-01

    Full Text Available This brief paper intends to highlight the contradictions in which liberal democracy struggles within the process of globalisation, influenced as it is by the new connecting technologies. In particular, the difficult relationship between liberalism and democracy is analysed in light of the latest communitarist theories and new trends that interpret them socially. 

  20. Millian Liberal Feminism Today.

    Science.gov (United States)

    Tulloch, Gail

    1989-01-01

    It is proposed that John Stuart Mill's principles on liberal feminism are still relevant and have not yet been fully implemented. A Millian account of equality of opportunity and discrimination is developed, and current measures in the field of sexual equality are critiqued. (Author/MSE)

  1. The Schism in Liberal Thought: A Transition from Social Liberalism to Socialism?

    Science.gov (United States)

    Childs, John Brown

    1981-01-01

    Studies the significance of the conservative victory in the 1980 election. Also evaluates the increasing support of conservative policies such as the dismantling of civil rights, women's rights, and environmental gains. Concludes that an important element in this drift to the right is the resurgence of laissez-faire liberalism. (DB)

  2. The importance of γ-linolenic acid in the prevention and treatment

    Directory of Open Access Journals (Sweden)

    Małgorzata Białek

    2015-07-01

    Full Text Available The etiology of diet-related disorders is closely associated with dietary factors. A special role is attributed to intake of fat and fatty acid profile, both quantitative and qualitative. For prevention and treatment of the abovementioned diseases a proper supply of unsaturated fatty acids plays a significant role, because of their particular importance to health. γ-Linolenic acid (GLA, with three double bonds in the carbon chain, also known as all-cis 6,9,12-octadecatrienoic acid, belongs to the n-6 family of fatty acids. It plays biologically important functions in the human body, such as being a substrate for eicosanoids synthesis, involvement in the transport and oxidation of cholesterol, and being one of the components of lipid membrane. Its inadequate dietary intake or impaired formation is the cause of many inflammatory and degenerative diseases. A rich source of this fatty acid is vegetable oils, until recently used mainly in folk medicine. Nowadays, studies conducted both in animal models and in humans suggest its health-promoting properties in the prevention and treatment of atopic dermatitis, cardiovascular diseases, diabetes, cancers and rheumatoid arthritis.

  3. An Analysis of Trade Liberalization in Services: A Korea-ASEAN FTA

    Directory of Open Access Journals (Sweden)

    Soon-Chan Park

    2005-06-01

    Full Text Available As tariffs have fallen worldwide through multilateral negotiations, the focus of free trade agreements has shifted towards other issues, including trade liberalization in services, harmonization of technical standards, and so on. Korea and ASEAN established a Joint Study to examine the feasibility and desirability of a comprehensive FTA. This paper evaluates the impacts of trade liberalization in services of a Korea-ASEAN FTA using a computable general equilibrium model. We use a modified version of the GTAP model that captures trade liberalization in services. As services are an input into the production of most industries, an inefficient service sector can be very costly to the economy as a whole. From the general equilibrium perspective, liberalizAs tariffs have fallen worldwide through multilateral negotiations, the focus of free trade agreements has shifted towards other issues, including trade liberalization in services, harmonization of technical standards, and so on. Korea and ASEAN established a Joint Study to examine the feasibility and desirability of a comprehensive FTA. This paper evaluates the impacts of trade liberalization in services of a Korea-ASEAN FTA using a computable general equilibrium model. We use a modified version of the GTAP model that captures trade liberalization in services. As services are an input into the production of most industries, an inefficient service sector can be very costly to the economy as a whole. From the general equilibrium perspective, liberalization in services gives manufacturing industries access to low cost, high quality service inputs so that they can be competitive. This implies that the positive effects of trade liberalization in services are never negligible. We find that the impacts of service liberalization on GDP and welfare are significant. If trade barriers to services are reduced by 60 percentages, it is estimated that Korea's GDP would increase by 0.21 percentages.

  4. Economic liberalization and globalization vs. India's poor

    OpenAIRE

    Oschinski, Matthias

    2003-01-01

    Today, many in the national and international NGO community perceive globalization and economic liberalization as a threat claiming that it widens inequalities and increases overall poverty. While it is true that inequality is on the rise in a rapidly globalizing world the real culprit is not globalization itself but rather a lack of economic reforms and economic liberalization. This paper aims to show that many in the international NGO community confuse cause and effect. The root cause of po...

  5. Conservatives report, but liberals display, greater happiness.

    Science.gov (United States)

    Wojcik, Sean P; Hovasapian, Arpine; Graham, Jesse; Motyl, Matt; Ditto, Peter H

    2015-03-13

    Research suggesting that political conservatives are happier than political liberals has relied exclusively on self-report measures of subjective well-being. We show that this finding is fully mediated by conservatives' self-enhancing style of self-report (study 1; N = 1433) and then describe three studies drawing from "big data" sources to assess liberal-conservative differences in happiness-related behavior (studies 2 to 4; N = 4936). Relative to conservatives, liberals more frequently used positive emotional language in their speech and smiled more intensely and genuinely in photographs. Our results were consistent across large samples of online survey takers, U.S. politicians, Twitter users, and LinkedIn users. Our findings illustrate the nuanced relationship between political ideology, self-enhancement, and happiness and illuminate the contradictory ways that happiness differences can manifest across behavior and self-reports. Copyright © 2015, American Association for the Advancement of Science.

  6. School religious education in a liberating perspective

    Directory of Open Access Journals (Sweden)

    José Luis Meza Rueda

    2015-06-01

    Full Text Available Religious education in Colombia, according to Law 115 of 1994, is an area of fundamental training. However, its purpose of promoting the religious dimension of human beings and understanding the role of religion in culture is far from being achieved, because, in practice, it is considered as an area of second order, is disjointed from the curriculum and is still working as the “religion lesson” of the past. What to do against this? Could it be another way of thinking about religious education? We estimate that, as presuppositions and motivations of both liberation theology and liberating pedagogy are still valid today, they may provide clues in this respect. Consequently, this paper not only makes a detailed reading of this reality in some official educational institutions in Colombia, but also sheds light for the school religious education (ERE to be liberating.

  7. A Third Way: Integrating Liberal and Professional Education

    Science.gov (United States)

    Freeland, Richard

    2016-01-01

    In this article, the author discusses Experiential Education and Liberal Learning. This topic has been on the mind of the author ever since he graduated from a liberal arts college many years ago and began his first real job, whereupon he discovered how much he did not know about putting his ideas to effective use in the world beyond academia. In…

  8. 29 CFR 1620.34 - Rules to be liberally construed.

    Science.gov (United States)

    2010-07-01

    ... Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.34 Rules to be liberally construed. (a) These rules and regulations shall be liberally construed to effectuate the purpose and provisions of this Act and any other Act administered by the...

  9. Art’s Commitment to Liberation in Marcuse’s Philosophy

    Directory of Open Access Journals (Sweden)

    Ding Guogi

    2015-04-01

    Full Text Available Art has a liberating function because it stands on the opposite side of a suppressed society; it is deeply connected with the public’s daily life and has an inherent characteristic of “catharsis”, like describing a good society and identifying with freedom. In the eyes of the theorists of the Frankfurt School, its form is what makes “art” art, while the autonomy of art is what realizes the transcendence and detachment of art over and from society and politics in reality by constructing a new and tangible kingdom of art. Artistic form, artistic autonomy, and the liberation of mankind are the integral parts that form art and they constitute all the elements that are needed in the art world. For as long as art exists, it will keep its commitment to truth, happiness, and liberation. This paper examines the inevitable inherent relationship between art and liberation mainly through discussing and studying Marcuse’s theories of art and aesthetics.

  10. Shifting liberal and conservative attitudes using moral foundations theory.

    Science.gov (United States)

    Day, Martin V; Fiske, Susan T; Downing, Emily L; Trail, Thomas E

    2014-12-01

    People's social and political opinions are grounded in their moral concerns about right and wrong. We examine whether five moral foundations--harm, fairness, ingroup, authority, and purity--can influence political attitudes of liberals and conservatives across a variety of issues. Framing issues using moral foundations may change political attitudes in at least two possible ways: (a) Entrenching: Relevant moral foundations will strengthen existing political attitudes when framing pro-attitudinal issues (e.g., conservatives exposed to a free-market economic stance) and (b) Persuasion: Mere presence of relevant moral foundations may also alter political attitudes in counter-attitudinal directions (e.g., conservatives exposed to an economic regulation stance). Studies 1 and 2 support the entrenching hypothesis. Relevant moral foundation-based frames bolstered political attitudes for conservatives (Study 1) and liberals (Study 2). Only Study 2 partially supports the persuasion hypothesis. Conservative-relevant moral frames of liberal issues increased conservatives' liberal attitudes. © 2014 by the Society for Personality and Social Psychology, Inc.

  11. LIBER 2010 / Mihkel Volt

    Index Scriptorium Estoniae

    Volt, Mihkel

    2010-01-01

    LIBER-i 2010. aasta konverentsi pealkirjaks oli "Taasavastades raamatukogu - uue infokeskkonna väljakutsed". Århusis toimunud konverentsil käsitleti nii teadusraamatukogu rolli e-teaduses ja e-õppes, teavikute massilist digiteerimist ja kollektsioonide säilitamist kui ka "taasavastatud raamatukogu" juhtimist, arutleti nende teemade kombineerimisvõimaluste üle

  12. Effects of an accelerated liberalization. Consequences of accelerated liberalization for the competitiveness of Dutch energy companies

    International Nuclear Information System (INIS)

    Kaal, M.B.T.

    2001-08-01

    One of the conclusions of the Dutch Energy Report, published at the end of 1999, was that it would be feasible to speed up the pace of liberalization in the Netherlands. This conclusion will lead to the liberalization of the retail customers in 2004 and the market for renewable energy in 2001. This will be an incentive to more competition and put a greater pressure on energy companies to concentrate in order to benefit from economies of scale. Less preparation time implies also that there will be less layers of isolation against cost leaders and hence a more intense (price-based) competition. The central question in this report is whether and to what extent the effects of policy, in particular the accelerated liberalization, affect the strategic behavior and competitiveness of the Dutch Regional Electricity Companies (RECs). To address this question four face-to-face interviews have been held with experts from the four major RECs. In these interviews the experts gave their opinion about the Dutch policy regarding the accelerated liberalization and the rate and extent of the privatization. Subsequently, their perspective on the impact of the policy on their competitiveness and their analysis of the Dutch energy market was recorded. After that, the experts exposed their outlook on the future energy market and the ambition and most likely direction of their companies. The data collection was complemented with numerous relevant public interviews of experts derived from various newspapers and energy magazines. The data thus collected were analyzed by means of a theoretical framework consisting of the insights of Porter, Prahalad and Hamel and at a more detailed level marketing theories regarding positioning and branding. This resulted in an overview of the current market position of the Dutch RECs and an outlook for the years to come. 27 refs

  13. Transboundary Pollution, Trade Liberalization, and Environmental Taxes

    International Nuclear Information System (INIS)

    Baksi, S.; Ray Chaudhuri, A.

    2008-01-01

    In a bilateral trade framework, we examine the impact of tariff reduction on the optimal pollution tax and social welfare when pollution is transboundary. Strategic considerations lead countries to distort their pollution tax in the non-cooperative equilibrium. Trade liberalization changes the distortion, and consequently the pollution tax and welfare, in ways that depend on the extent to which pollution is transboundary. We find that when the pollution damage parameter is sufficiently small (large), bilateral tariff reduction always decreases (increases) the pollution tax, irrespective of the value of the transboundary pollution parameter. However, when the pollution damage parameter takes intermediate values, bilateral tariff reduction decreases the pollution tax if and only if the transboundary pollution parameter is sufficiently large (or even sufficiently small, in certain cases). Moreover, with pollution being transboundary, the impact of trade liberalization on welfare is non-monotonic and concave. The greater the extent to which pollution crosses borders, the more likely is trade liberalization to reduce welfare

  14. Transboundary Pollution, Trade Liberalization, and Environmental Taxes

    Energy Technology Data Exchange (ETDEWEB)

    Baksi, S. [Department of Economics, University of Winnipeg, Winnipeg (Canada); Ray Chaudhuri, A. [Department of Economics, CentER, TILEC, Tilburg University, Tilburg (Netherlands)

    2008-08-15

    In a bilateral trade framework, we examine the impact of tariff reduction on the optimal pollution tax and social welfare when pollution is transboundary. Strategic considerations lead countries to distort their pollution tax in the non-cooperative equilibrium. Trade liberalization changes the distortion, and consequently the pollution tax and welfare, in ways that depend on the extent to which pollution is transboundary. We find that when the pollution damage parameter is sufficiently small (large), bilateral tariff reduction always decreases (increases) the pollution tax, irrespective of the value of the transboundary pollution parameter. However, when the pollution damage parameter takes intermediate values, bilateral tariff reduction decreases the pollution tax if and only if the transboundary pollution parameter is sufficiently large (or even sufficiently small, in certain cases). Moreover, with pollution being transboundary, the impact of trade liberalization on welfare is non-monotonic and concave. The greater the extent to which pollution crosses borders, the more likely is trade liberalization to reduce welfare.

  15. Past-focused temporal communication overcomes conservatives' resistance to liberal political ideas.

    Science.gov (United States)

    Lammers, Joris; Baldwin, Matt

    2018-04-01

    Nine studies and a meta-analysis test the role of past-focused temporal communication in reducing conservatives' disagreement with liberal political ideas. We propose that conservatives are more prone to warm, affectionate, and nostalgic feelings for past society. Therefore, they are more likely to support political ideas-including those expressing liberal values-that can be linked to a desirable past state (past focus), rather than a desirable future state (future focus) of society. Study 1 supports our prediction that political conservatives are more nostalgic for the past than liberals. Building on this association, we demonstrate that communicating liberal ideas with a past focus increases conservatives' support for leniency in criminal justice (Studies 2a and 2b), gun control (Study 3), immigration (Study 4), social diversity (Study 5), and social justice (Study 6). Communicating messages with a past focus reduced political disagreement (compared with a future focus) between liberals and conservatives by between 30 and 100% across studies. Studies 5 and 6 identify the mediating role of state and trait nostalgia, respectively. Study 7 shows that the temporal communication effect only occurs under peripheral (and not central) information processing. Study 8 shows that the effect is asymmetric; a future focus did not increase liberals' support for conservative ideas. A mixed-effects meta-analysis across all studies confirms that appealing to conservatives' nostalgia with a past-focused temporal focus increases support for liberal political messages (Study 9). A large portion of the political disagreement between conservatives and liberals appears to be disagreement over style, and not content of political issues. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  16. Liberal rationalism and medical decision-making.

    Science.gov (United States)

    Savulescu, Julian

    1997-04-01

    I contrast Robert Veatch's recent liberal vision of medical decision-making with a more rationalist liberal model. According to Veatch, physicians are biased in their determination of what is in their patient's overall interests in favour of their medical interests. Because of the extent of this bias, we should abandon the practice of physicians offering what they guess to be the best treatment option. Patients should buddy up with physicians who share the same values -- 'deep value pairing'. The goal of choice is maximal promotion of patient values. I argue that if subjectivism about value and valuing is true, this move is plausible. However, if objectivism about value is true -- that there really are states which are good for people regardless of whether they desire to be in them -- then we should accept a more rationalist liberal alternative. According to this alternative, what is required to decide which course is best is rational dialogue between physicians and patients, both about the patient's circumstances and her values, and not the seeking out of people, physicians or others, who share the same values. Rational discussion requires that physicians be reasonable and empathic. I describe one possible account of a reasonable physician.

  17. Ideology Spotting: An Exercise in Teaching Conservatism and Liberalism

    Science.gov (United States)

    Plazek, David J.

    2012-01-01

    It has long been lamented that Americans do not comprehend conservative and liberal ideologies and the associated policy preferences for each perspective (and the reasoning behind the associations). This research seeks to contribute to the teaching of conservatism and liberalism by creating a heuristic outlining six general characteristics for…

  18. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer

    International Nuclear Information System (INIS)

    Li, Ying; Zhao, Haixia; Wang, Yuzhong; Zheng, Hao; Yu, Wei; Chai, Hongyan; Zhang, Jing; Falck, John R.; Guo, Austin M.; Yue, Jiang; Peng, Renxiu; Yang, Jing

    2013-01-01

    Arachidonic acid (AA)-derived eicosanoids and its downstream pathways have been demonstrated to play crucial roles in growth control of breast cancer. Here, we demonstrate that isoliquiritigenin, a flavonoid phytoestrogen from licorice, induces growth inhibition and apoptosis through downregulating multiple key enzymes in AA metabolic network and the deactivation of PI3K/Akt in human breast cancer. Isoliquiritigenin diminished cell viability, 5-bromo-2′-deoxyuridine (BrdU) incorporation, and clonogenic ability in both MCF-7 and MDA-MB-231cells, and induced apoptosis as evidenced by an analysis of cytoplasmic histone-associated DNA fragmentation, flow cytometry and hoechst staining. Furthermore, isoliquiritigenin inhibited mRNA expression of multiple forms of AA-metabolizing enzymes, including phospholipase A2 (PLA2), cyclooxygenases (COX)-2 and cytochrome P450 (CYP) 4A, and decreased secretion of their products, including prostaglandin E 2 (PGE 2 ) and 20-hydroxyeicosatetraenoic acid (20-HETE), without affecting COX-1, 5-lipoxygenase (5-LOX), 5-lipoxygenase activating protein (FLAP), and leukotriene B 4 (LTB 4 ). In addition, it downregulated the levels of phospho-PI3K, phospho-PDK (Ser 241 ), phospho-Akt (Thr 308 ), phospho-Bad (Ser 136 ), and Bcl-x L expression, thereby activating caspase cascades and eventually cleaving poly(ADP-ribose) polymerase (PARP). Conversely, the addition of exogenous eicosanoids, including PGE 2 , LTB 4 and a 20-HETE analog (WIT003), and caspase inhibitors, or overexpression of constitutively active Akt reversed isoliquiritigenin-induced apoptosis. Notably, isoliquiritigenin induced growth inhibition and apoptosis of MDA-MB-231 human breast cancer xenografts in nude mice, together with decreased intratumoral levels of eicosanoids and phospho-Akt (Thr 308 ). Collectively, these data suggest that isoliquiritigenin induces growth inhibition and apoptosis through downregulating AA metabolic network and the deactivation of PI3K/Akt in

  19. Science and the Ideals of Liberal Education

    Science.gov (United States)

    Carson, Robert N.

    This article examines the influence of mathematics and science on the formation of culture. It then examines several definitions of liberal education, including the notion that languages and fields of study constitute the substrate of articulate intelligence. Finally, it examines the linkages between science, scientific culture, liberal education, and democracy, and proposes that science cannot be taught merely as a body of facts and theories, but must be presented to students as integral with cultural studies. The use of a contextualist approach to science education is recommended.

  20. Feminismo e estado: desafiando a democracia liberal

    Directory of Open Access Journals (Sweden)

    Silvana Aparecida Mariano

    2001-12-01

    Full Text Available This article deals with the development of the feminism movement in Brazil focusing on its change of definition of State, as well as its conflicts with the principles of liberal democracy. The central focus of discussion is the contribution of the feminism demands, since they bring into debate the limitations of liberal democratic regimes, thus creating new democratic principles. Such reorganization is discussed upon feminism demands for public policies concerning gender issues, especially affirmative actions seeking to compensate for the disadvantages experienced by women.

  1. Norway in a liberalized European energy market

    International Nuclear Information System (INIS)

    Aune, Finn Roar; Golombek, Rolf; Rosendahl, Knut Einar; Kittelsen, Sverre A.C.

    2000-01-01

    The authors study the short-term effects of a comprehensive liberalization of the gas and power markets in Europe. The analysis is based on a statically applied general equilibrium model which gives an overall and consistent treatment of the energy markets in Europe. The model preserves the structural features in the production, transport and consumption of gas and electricity in Europe, as well as the new competitive situation arising from the liberalization. It is found that the liberalization leads to a strong fall in the price of electricity. The fall in price reflects increased competition and that idle capacity in the power sector is used to increase the production of electricity. In comparison with the real observations in 1996 (the basis year of the model) the price to the end-user is cut in half. The liberalization also leads to a fall in the price of gas. The price fall reflects in part increased competition, in part the fact that falling prise of electricity reduces the demand for gas. However, the price reduction (in per cent) is not as great as for electricity. The model is also used to study the effects in Norway of increased gas production when the gas is either used in increased gas power production in Norway, or is exported. The main conclusion is that (1) the total emission of carbon dioxide goes down in Western Europe, (2) the reduction is greatest if the gas is burned as gas power in Norway

  2. THE IMPACT OF FINANCIAL LIBERALIZATION ON ROMANIAN BANKING SYSTEM EFFICIENCY

    Directory of Open Access Journals (Sweden)

    Ciupac-Ulici Maria-Lenuta

    2013-07-01

    Full Text Available In the last three decades, many emerging countries have moved away from a system of restrictive monetary and financial controls to a more liberalized financial sector. The restrictive imposed policies were expected to contribute to industrialization of the economy and to the stability of the banking sector. However, financial liberalization had big costs on the banking system's competitiveness and efficiency. Financial liberalization has a different impact on banking markets. Thus, there is no size that fits all policies concerning banking liberalization process. For highly efficient banks, competition is improving their efficiency standard, while less efficient banks can`t compete with foreign banks and further are decreasing in efficiency or are driven out of the market. Overall, the average efficiency of domestic banking markets should be an important variable in deciding to open up their banking market. Banks that are operating close to the frontier, in general are improving their efficiency following financial liberalization process. Banks that are operating in a further distance can`t manage to compete with foreign market entrants, so, they are losing from liberalization process. In this article we propose to measure the impact of financial liberalization process on Romanian banking system. We used the panel regression to study the informational efficiency of three Romanian banks during 2004 - 2012. The dependent variable of the model was the price of stock bank, and the independent variables were the financial indicators (return on equity, return on assets, net profit margin. In the second regression we introduce a dummy variable for crisis period. Our results show that the financial indicators choose do not affect the efficiency of Romanian bank, but the crisis had a negative impact on them. International context, credit risk, the implementation of Basel III and reducing exposures in the absence of investment alternatives remains key

  3. Platform for the acceleration of energy liberalization (PVE)

    International Nuclear Information System (INIS)

    2000-01-01

    The title platform was founded to support a smooth transition to a liberalized energy market. Representatives of the Dutch government, the energy sector, business and industry and other relevant parties are members of the platform. The platform was officially initiated June 22, 2000. The site contains many documents from the PVE working groups on the liberalization process of the energy market in the Netherlands and Europe in pdf-format [nl

  4. Populism, liberal democracy and the ethics of peoplehood

    DEFF Research Database (Denmark)

    Wolkenstein, Fabio

    2016-01-01

    . The point of this exercise is not to dismiss populism in toto; the article strives for a more subtle result, namely, to show that liberal democracy can accommodate populism provided that the latter conforms to particular discursive norms. What the article calls a ‘liberal ethics of populism’ turns out...... actors: its addressees are all those who seek legitimately to exercise power in the name of the people....

  5. Is the Liberal Defense of Public Schools a Fantasy?

    Science.gov (United States)

    Merry, Michael S.; New, William S.

    2017-01-01

    In this paper, we offer a Leftist critique of standard liberal defenses of the public school. We suggest that the standard arguments employed by mainstream liberal defenders of the public school are generally inadequate because they fail to provide a credible representation of their historical object, let alone effective remedies to our current…

  6. REASONING OF LIBERAL ISLAM: A STUDY ON ISLAMIC PERSPECTIVES IN LIBERAL ISLAM NETWORK JAKARTA

    Directory of Open Access Journals (Sweden)

    Yusa' Farchan

    2016-12-01

    Full Text Available The renewal of Islamic thinking continuously develops from time to time in Indonesia. This research tries to answer two main problems, they are: how are the reasoning or ideology developed by Liberal Islam Network (LIN?; and how are LIN’s main ideas and their metamorphoses? The research applies qualitative method with hermeneutic approach. The data is collected by library research or text documentation. The data is collected on August 18th to August 29th 2015. The research finds that the ideas of Liberal Islam Network show significant liberal signs. From the ontology of text, in reading religious text, LIN’s assumptions are “the critics over the truth”. LIN applies humanistic approach in reading the religious texts. This is confirmed by LIN’s defense toward human’s dignity. From the aspect of theoretically analytical tools in reading religious texts, LIN applies social sciences, which are socio-historical analyses. LIN uses symbol or semiotics analyses to read the religious text. The main notions of LIN are: First, Islam changes, it is not static; second, context is the first and history is the latter. Here, in reading a religious text, LIN wants to place context (socio-history proportionally; third, LIN intends to hold God in our ground and history. The metamorphoses of LIN’s ideas are: firstly is to oppose theocracy; secondly is to endorse democracy; thirdly is to endorse gender equality; fourthly is to contextualize religious doctrines; and fifthly is to support pluralism and freedom of thinking.

  7. Metallic gold beads in hyaluronic acid

    DEFF Research Database (Denmark)

    Pedersen, Dan Sonne; Tran, Thao Phuong; Smidt, Kamille

    2013-01-01

    . In conclusion, our findings support that bio-liberation of gold from metallic gold surfaces have anti-inflammatory properties similar to classic gold compounds, warranting further studies into the pharmacological potential of this novel gold-treatment and the possible synergistic effects of hyaluronic acid....... by exploiting macrophage-induced liberation of gold ions (dissolucytosis) from gold surfaces. Injecting gold beads in hyaluronic acid (HA) as a vehicle into the cavities of the brain can delay clinical signs of disease progression in the MS model, experimental autoimmune encephalitis (EAE). This study...... investigates the anti-inflammatory properties of metallic gold/HA on the gene expression of tumor necrosis factor (Tnf-α), Interleukin (Il)-1β, Il-6, Il-10, Colony-stimulating factor (Csf)-v2, Metallothionein (Mt)-1/2, Bcl-2 associated X protein (Bax) and B cell lymphoma (Bcl)-2 in cultured J774 macrophages...

  8. What Future for Student Engagement in Neo-Liberal Times?

    Science.gov (United States)

    Zepke, Nick

    2015-01-01

    The paper first examines the context that has given student engagement a very strong profile in higher education. It identifies neo-liberalism as the driving force in the present higher education context and argues that student engagement enjoys an elective affinity with it. While neo-liberalism is dominant, student engagement will be strong. But…

  9. Spirit of Liberation and Justice in Farid Esack’s Hermeneutics of Qur’an

    Directory of Open Access Journals (Sweden)

    Erik Sabti Rahmawati

    2016-06-01

    Full Text Available Farid Esack is an Islamic thinker from South Africa who proposes Liberation hermeneutics in comprehending the Qur’an from the perspective of Liberation Theology to realize justice. This article examines Esack’s hermeneutical method in interpreting Qur’an and analyses how he applies the spirit of liberation and justice as principles of Liberation Theology in his interpretation. This study shows that Esack’s hermeneutics differs from others because, as a liberation theologian, he puts liberative-praxis as the main objective of his liberation theology. His method does not only revolve around textual understanding but also push practical implication. He moves forward from praxis (experience to texts and then goes back to experience. To him, interpretation must be able to encourage changes within society. Therefore, as the second feature of this method, in Esack’s hermeneutics, interpretation is not just scholarly speculative exercise which has no implication. It has a specific aim, namely is to establish a better life for society in which justice is a fundamental prerequisite. DOI: http://dx.doi.org/10.20414/ujis.v20i1.822

  10. El contrato social en Hobbes: ¿absolutista o liberal? Hobbes’ Social Contract: Absolutist or Liberal?

    Directory of Open Access Journals (Sweden)

    Francisco Cortés Rodas

    2010-12-01

    Full Text Available En este artículo se presentan los elementos centrales del modelo contractualista clásico de legitimación del Estado, expuesto por Thomas Hobbes en el Leviatán. Se cuestiona la interpretación propuesta por Leo Strauss sobre la filosofía política de Hobbes, según la cual, el filósofo inglés sería el fundador del liberalismo. Mediante una interpretación de la teoría de la representación política hobbesiana se intenta destacar su imagen como defensor del absolutismo político. El tipo de liberalismo a partir del cual es posible mostrar que la concepción de Hobbes resulta inaceptable es el liberalismo representado por autores como Benjamin Constant, Madame de Stäel y Alexis de Tocqueville.This article presents the central elements of the classic contractualist model of State legitimacy as displayed by Thomas Hobbes in Leviathan. It aims to question the proposal made by Leo Strauss on Hobbes’ political philosophy according to which Hobbes is the founder of liberalism. Through an interpretation of the Hobbesian theory of political representation, it intends to detach his image as a defender of political absolutism. The type of liberalism from which it is possible to show that Hobbes’ conception is unacceptable, is liberalism represented by authors such as Benjamin Constant, Madame de Stäel and Alexis de Tocqueville.

  11. The Conservative Challenge to Liberalism

    NARCIS (Netherlands)

    Claassen, R.J.G.

    2011-01-01

    This paper reconstructs the political–theoretical triangle between liberalism, communitarianism and conservatism. It shows how these three positions are related to each other and to what extent they are actually incompatible. The substantive outcome is the following thesis: the conservative position

  12. Liberty, Authority, and Character Cultivation: John Stuart Mill's Revised Liberal Theories.

    Science.gov (United States)

    Kim, Ki Su

    1988-01-01

    The article examines educational changes recommended by Mill in his liberal political theories to point out some of the attempts of liberals to adjust themselves to changing historical circumstances. (CB)

  13. The Degree of Financial Liberalization and Aggregated Stock-return Volatility in Emerging Markets

    NARCIS (Netherlands)

    Umutlu, M.; Akdeniz, L.; Salih, A.A.

    2009-01-01

    In this study, we address whether the degree of financial liberalization affects the aggregated total volatility of stock returns by considering the time-varying nature of financial liberalization. We also explore channels through which the degree of financial liberalization impacts aggregated total

  14. Comparison of the effect of timegadine, levamisole, and D-penicillamine on human neutrophil metabolism of endogenous arachidonic acid and chemotaxis

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, O.H.; Ahnfelt-Roenne, I. Department of Pharmacology, Leo Pharmaceutical Products, Ballerup; Elmgreen, J.

    1988-01-01

    The effect of timegadine, a novel experimental antirheumatic drug, on human neutrophil (PMN) 5-lipoxygenase activity and leukotriene B/sub 4/ (LTB/sub 4/) chemotaxis was compared with that of two second-line antiinflammatory drugs, D-penicillamine and levamisole. 1-/sup 14/C-Arachidonic acid (AA) was incorporated into the purified cells until steady state conditions were obtained. After preincubation with serial dilutions of the three drugs, AA release and metabolism was stimulated with calcium ionophore A23187. The radioactive eicosanoids released were extracted and separated by thinlayer chromatography, followed by autoradiography and quantitative laser densitometry. Chemotaxi of PMNs towards LTB/sub 4/ was measured in a modified Boyden chamber. Timegardine showed dose-dependent inhibition of both the 5-lipoxygenase pathway (IC50 3.4 x 10/sup -5/ M), and of chemotaxis (IC50 3 x 10/sup -4/ M). Inhibition of the release of AA from phospholipids, however, occurred only at therapeutically irrelevant doses (millimolar concentrations). Levamisole and D-penicillamine did not inhibit any of the cell functions investigated. Inhibition of both neutrophil motility and cellular synthesis of pro-inflammatory eicosanoids, may thus contribute to the clinical effects of timegadine in rheumatoid arthritis.

  15. The effects of Trade Liberalization on the Consumption Function in ...

    African Journals Online (AJOL)

    This paper investigates the 1983 trade liberalization and inflation on the consumption function of Morocco. Findings indicate that trade liberalization and moderate inflation had little impact on consumption. The results do, however, show strong support for the permanent income hypothesis because lagged consumption was ...

  16. La evaluación social en el Estado Liberal La evaluación social en el Estado Liberal

    Directory of Open Access Journals (Sweden)

    Leonardo Solarte Pazo

    2003-06-01

    Full Text Available This article treats on the social evaluation, particularly referred to the state interventions by means of policies, programs or public projects, approaching the public evaluation like a discipline in whom elements of diverse fields of the knowledge are conjugatedsuch as political science, the public policies and the public administration.Its intention is to make notice the existing relation between the evaluative theory andthe principles of political liberalism, as well as the potential importance of the evaluativepractice within the liberal state of well-being. In the first case some existing theoreticalnexuses between the evaluative theory and the liberal political theory are identified, inthree dimensions: axiological, epistemological and the conception of the state.In the second case, diverse forms appear to conceive the roll of the evaluation like a toolof conformation of the democracy, political and social learning, as well as mechanism toimprove the management of the government.Este artículo trata sobre la evaluación social, particularmente referida a las intervenciones estatales mediante políticas, programas o proyectos públicos, abordando la evaluación como una disciplina en la que se conjugan elementos de diversos campos del conocimiento y específicamente la ciencia política, las políticas públicas y la administración pública.Su intención es hacer notar la relación existente entre la teoría evaluativa y los principiosdel liberalismo político,   así como la potencial importancia de la práctica de la evaluacióndentro del estado liberal de bienestar. En el primer caso se plantean algunos nexos teóricosexistentes entre la teoría evaluativa y la teoría política liberal, en tres dimensiones:axiológica, epistemológica y la concepción del Estado. En el segundo caso, se presentandiversas formas de concebir el rol de la evaluación como una herramienta de conformaciónde la democracia, aprendizaje político y social

  17. The Role of Omega-3 Polyunsaturated Fatty Acids in the Treatment of Patients with Acute Respiratory Distress Syndrome: A Clinical Review

    Directory of Open Access Journals (Sweden)

    M. García de Acilu

    2015-01-01

    Full Text Available Acute respiratory distress syndrome (ARDS is defined as the acute onset of noncardiogenic edema and subsequent gas-exchange impairment due to a severe inflammatory process. Recent report on the prognostic value of eicosanoids in patients with ARDS suggests that modulating the inflammatory response through the use of polyunsaturated fatty acids may be a useful strategy for ARDS treatment. The use of enteral diets enriched with eicosapentaenoic acid (EPA and gamma-linolenic acid (GLA has reported promising results, showing an improvement in respiratory variables and haemodynamics. However, the interpretation of the studies is limited by their heterogeneity and methodology and the effect of ω-3 fatty acid-enriched lipid emulsion or enteral diets on patients with ARDS remains unclear. Therefore, the routine use of ω-3 fatty acid-enriched nutrition cannot be recommended and further large, homogeneous, and high-quality clinical trials need to be conducted to clarify the effectiveness of ω-3 polyunsaturated fatty acids.

  18. Liberal Liability. Understanding Students’ Conceptions of Gender Structures

    Directory of Open Access Journals (Sweden)

    Linda Murstedt

    2014-04-01

    Full Text Available Research has shown that teaching gender theories tends to be an educational challenge and elicits student resistance. However, little is known about students’ learning processes in social science. This study aims to explore these learning processes by drawing on feminist pedagogy and conceptual change theory. The results show that when students are asked to perform analysis from a structural gender perspective, they recurrently introduce other explanatory frameworks based on non-structural understandings. The students’ learning processes involve reformulating questions and making interpretations based on liberal understandings of power, freedom of choice and equality. We argue that this process is due to the hegemonic position of the liberal paradigm as well as to the dominant ideas about science. Clarifying the underlying presumptions of a liberal perspective and a structural perspective may help students to recognise applied premises and enable them to distinguish relevant explanations.

  19. Trade Liberalization between Russia and East Asian Countries

    Directory of Open Access Journals (Sweden)

    Dmitriy Aleksandrovich Izotov

    2015-12-01

    Full Text Available Based on the international statistics data the author estimates effects of trade liberalization between Russia and East Asian countries. The prospective niche markets in mutual trade and the impact of trade liberalization on the national economies were identified. Using a partial equilibrium model the author indicates the following positive trade effects for Russia and East Asia: trade creation effect prevails over trade diversion effect; general welfare and mutual trade of the countries tend to increase. The Russian economy has positive trade effects with all the East Asian countries, with the highest scale in the case of Sino-Russian trade. At the same time trade liberalization has following some costs for the Russian economy: a the growing role of imports, mostly from China, compared to Russian exports; b reduction of tariff revenues, which are four times higher for Russia, compared to East Asian countries; c continued negative trade balance with the East Asian countries. The evaluation shows that the increase of Russian exports to East Asian countries is feasible only for certain commodity groups which determine marketable niches of specific East Asian countries; at the same time, Russia can import from East Asia a huge range of commodity groups. The study reveals that reduction in tariff measures and non- tariff restrictions will not lead to a massive increase in Russian exports and changing in its trade and geographical structure. On the basis of prolongation of short-term trends the author identifies long-term challenges and opportunities for the Russian economy from trade liberalization with East Asian countries. According to the estimation results, the author suggests that in the current environment of global trade liberalization the tariff measures become less significant as a tool for redistribution of commodity flows

  20. Technology mix configuration in liberalized electricity market

    International Nuclear Information System (INIS)

    Castro-Rodriguez, F.

    2007-01-01

    This paper analyzes the evolution of technology mix in the electricity industry when investment choices are left to private investors. In particular, possible failures and investment biases in recent liberalized electricity markets are presented. In addition, the main regulatory mechanisms used in practice and their effects are analyzed. Finally, this paper explores the government intervention in technology choices in the Spanish electricity market from the beginning of the liberalization process. While some regulatory rules have adequacy complemented the market functioning, others have distorted the electricity price, which is the reference to signal right investments. (Author) 13 refs

  1. Liberal bias and the five-factor model.

    Science.gov (United States)

    Charney, Evan

    2015-01-01

    Duarte et al. draw attention to the "embedding of liberal values and methods" in social psychological research. They note how these biases are often invisible to the researchers themselves. The authors themselves fall prey to these "invisible biases" by utilizing the five-factor model of personality and the trait of openness to experience as one possible explanation for the under-representation of political conservatives in social psychology. I show that the manner in which the trait of openness to experience is conceptualized and measured is a particularly blatant example of the very liberal bias the authors decry.

  2. THE UK ELECTRICITY MARKET EVOLUTION DURING THE LIBERALIZATION PROCESS

    Directory of Open Access Journals (Sweden)

    Delia Vasilica Rotaru

    2013-07-01

    Full Text Available This paper offers an insight on the liberalization process that took place in the United Kingdom starting with 1990 until now. The electricity market in the United Kingdom made incredible progress in the road to reaching a full level of liberalization where customers are free to choose between suppliers and services. An analysis of the most important indicators for the electricity market evolution such as electricity price, the market share of the largest generator, the energy efficiency indicator shows that the liberalization process brought many advantages starting with 2001. Also, UK has to face new challenges in order to keep the development of the industry on the right path, challenges that are presented in the final part of the paper.

  3. Consuming democracy : local agencies and liberal peace in the Democratic Republic of Congo

    NARCIS (Netherlands)

    Goede, J de M.

    2015-01-01

    This thesis focuses on liberal peace building in the DRC. The thesis takes a critical approach which emphasises local agencies and their engagements with liberal peace building. However, it seeks to bring this critique back to the institutions with which liberal peace building is preoccupied, by

  4. Thorbecke Revisited : The Role of Doctrinaire Liberalism in Dutch Politics

    NARCIS (Netherlands)

    Drentje, Jan

    2011-01-01

    Thorbecke Revisited: The Role of Doctrinaire Liberalism in Dutch Politics In the political history of the nineteenth century Thorbecke played a crucial role. As the architect of the 1848 liberal constitutional reform he led three cabinets. In many ways he dominated the political discourse during the

  5. Rethinking immigration policy theory beyond 'Western liberal democracies'.

    Science.gov (United States)

    Natter, Katharina

    2018-01-01

    How do political systems shape immigration policy-making? Explicitly or implicitly, comparative politics and migration policy theories suggest a 'regime effect' that links specific dynamics of immigration policy to liberal democracy. The literature's dominant focus on so-called 'Western liberal democracies', however, has left the 'regime effect' largely untested and research on variations and similarities in immigration policymaking across political systems strikingly undertheorized. This paper challenges the theoretical usefulness of essentialist, dichotomous categories such as Western/non-Western or democratic/autocratic and calls for a more nuanced theorizing of immigration policy-making. It proposes a two-dimensional classification of immigration policy theories, distinguishing between 'issue-specific' theories that capture immigration policy processes regardless of the political system in place and 'regime-specific' theories whose insights are tied to the characteristics of a political system. The paper also advances the 'illiberal paradox' hypothesis to explain why illiberal, autocratic states may enact liberal immigration policies. This theoretical expansion beyond the 'Western' and 'liberal' bubble is illustrated by an analysis of immigration policy-making in 21st century Morocco and Tunisia. Showing how domestic and international institutions, interests, and ideas shape immigration policy-making in Morocco's monarchy and Tunisia's democratic transition, the paper investigates the broader role of political systems in immigration politics and herewith seeks to contribute to a more general and global theorization of immigration policies.

  6. Financial liberalization and growth in African economies: The role of policy complementarities

    Directory of Open Access Journals (Sweden)

    Ousmanou Njikam

    2017-06-01

    Full Text Available This paper examines whether the effect of financial liberalization on economic growth depends on reform complementarities. A non-linear growth regression specification that interacts a proxy of financial liberalization with proxies of reform complementarities is estimated using a panel of 45 Sub-Saharan Africa (SSA countries. The cross-country, panel-data evidence shows no clear relationship between financial liberalization and growth. The study however finds that financial liberalization is more likely to positively and significantly increase growth across the SSA region if the following complementary reforms are undertaken e.g. improvement in educational attainment, macroeconomic and external stability, and overall governance.

  7. The Radical Thread - Liberalism and the rise of Labour in Scotland 1886 - 1924

    Directory of Open Access Journals (Sweden)

    Catriona MacDonald

    2011-09-01

    Full Text Available PreambleThis paper is a revised version of a lecture delivered to the Liberal Democrat History Meeting at the Scottish Liberal Democrat Conference in 2009. It was the subject of a report in the Journal of Liberal History (Winter 2009-2010, pp. 32-38. See also Catriona M.M. Macdonald, The Radical Thread: Political Change in Scotland, Paisley 1885-1924 (John Donald, 2000.Contemporary resonances are seductive when reflecting on the historic and recent past of the Liberal Party in Britain and i...

  8. Financial Liberalization and Economic Growth

    NARCIS (Netherlands)

    Bumann, S.; Hermes, N.; Lensink, B.W.

    2013-01-01

    This study provides a systematic analysis of the empirical literature on the relationship between financial liberalization and economic growth by conducting a meta-analysis, based on 441 t-statistics reported in 60 empirical studies. We focus on explaining the heterogeneity of results in our sample

  9. China’s interest rate liberalization reform

    OpenAIRE

    Li, Cindy

    2014-01-01

    This Asia Focus report explains the importance of interest rate liberalization in China, reviews historical progress and current efforts made to date, and discusses the potential impact on the banking sector.

  10. Beyond Survival in the 1980s for Liberal Arts Colleges.

    Science.gov (United States)

    Blecker, Michael

    1980-01-01

    Strict adherence to the mission of a church-related liberal arts college is seen as a viable approach to the 1980s. Trends to discredit the liberal arts, to use departmentalization to cope with knowledge, and to encroach on the college's domain with electronic advances are discussed. (Author/MLW)

  11. Educating for autonomy: liberalism and autonomy in the capabilities approach

    NARCIS (Netherlands)

    Ferracioli, L.; Terlazzo, T.

    2014-01-01

    Martha Nussbaum grounds her version of the capabilities approach in political liberalism. In this paper, we argue that the capabilities approach, insofar as it genuinely values the things that persons can actually do and be, must be grounded in a hybrid account of liberalism: in order to show

  12. Trade liberalization, social policies and health: an empirical case study.

    Science.gov (United States)

    McNamara, Courtney

    2015-10-12

    This study investigates the health impacts of a major liberalization episode in the textile and clothing (T&C) sector. This episode triggered substantial shifts in employment across a wide range of countries. It is the first study to empirically link trade liberalization to health via changes in employment and offers some of the first empirical insights on how trade liberalization interacts with social policies to influence health. Data from 32 T&C reliant countries were analysed in reference to the pre- and post-liberalization periods of 2000-2004 and 2005-2009. Fuzzy-set qualitative comparative analysis (fsQCA) was used to examine the association between countries' a) level of development b) labour market and welfare state protections c) T&C employment changes and d) changes in adult female and infant mortality rates. Process tracing was used to further investigate these associations through twelve in-depth country studies. Results from the fsQCA relate changes in employment after the phase-out to both changing adult female and infant mortality rates. Findings from the in-depth country studies suggest that the worsening of adult female mortality rates is related to workers' lack of social protection, both in the context of T&C employment growth and loss. Overall, it is found that social protection is often inaccessible to the type of workers who may be the most vulnerable to processes of liberalization and that many workers are particularly vulnerable due to the structure of social protection policies. Social policies are therefore found to both moderate pathways to health and influence the type of health-related pathways resulting from trade liberalizing policies.

  13. Liberalization of the electricity market. A success story in Austria

    International Nuclear Information System (INIS)

    Boltz, W.

    2002-01-01

    With effect from October 1,2001, every electricity consumer in Austria - from industrial consumer to private household - is now free to choose his own electricity supplier. Prior to this date only industrial consumers were able to benefit from the liberalization of the market initiated in the year 1999. Freedom of choice means increased competition between the various suppliers. Electricity consumers are the winners in the liberalization process, benefiting not only from lower prices, but in particular from greater customer care, various add-on offers and special additional facilities. All the signs are that the liberalization of the Austrian electricity market will continue to be a positive development in the future. (author)

  14. Proposal of emergency systems for the liberations control in a hydrogen producer plant with the cycle S-I

    International Nuclear Information System (INIS)

    Ruiz S, T.; Francois, J. L.; Nelson, P. F.; Cruz G, M. J.

    2012-10-01

    At present, one of the processes that theoretically has demonstrated to be of the most efficient for the hydrogen production is the thermal-chemistry cycle Sulfur-Iodine (S-I) coupled to a nuclear reactor of very high temperature (VHTR). Because this chemical process of hydrogen production requires of a great inventory of toxic materials (sulfurous compounds, hydriodic acid and iodine) is necessary the emergency systems design with the purpose of protecting the facilitates and equipment s, the atmosphere and population. Inside the important considerations for this design are the obtained results in the liberations simulations of the substances involved in the process. These simulations were realized with the computer code Phast, including the leak through a small failure of the pipe, as well as the catastrophic failure. To determine the good localization of the equipment s, as well as the inventory required for the liberations control. The operation conditions were taken of a combination of the preliminary design proposed by the General Atomics and the optimized conditions by the Korea Advanced Institute of Science and Technology, considering a hydrogen production of 1 kg-mol/s. The proposed materials for the neutralization of the liberated substances were selected considering that they did not increase the inventory of process toxic substances. (Author)

  15. Reconsideration of Rorty's View of the Liberal Ironist and Its Implications for Postmodern Civic Education

    Science.gov (United States)

    Kwak, Duck-Joo

    2004-01-01

    There have been persistent criticisms of Rorty's "liberal ironist" as the postmodern picture of the educated in the liberal utopia. While the modernist (Enlightenment) liberal Thomas McCarthy, who believes in universal rationality as the basis of public morality, criticizes Rorty's view of the liberal ironist for fostering the poverty of public…

  16. In view of unified market how liberalize the natural gas market

    International Nuclear Information System (INIS)

    Cavicchia, V.

    2000-01-01

    A liberalization to make in parallel with a electric market. That separate clearly the operations of retail and transport, that liberalize the access to stock, clear directions of prices structure avoid cartel agreement among transport managers [it

  17. Economic Liberalization and Political Violence

    International Development Research Centre (IDRC) Digital Library (Canada)

    The liberal promise has permeated international discourses and practices. In the ... Actually, many of the core principles of neoliberalism were specifically conceived of as ...... Di John, J. (2006) “The Political Economy of Taxation and Tax Reform in ...... Malaysia. Ireland. Guatemala. New Zealand. Italy. Honduras. Philippines.

  18. Indian Carpet Industry after Trade Liberalization. Problems and Prospects

    Directory of Open Access Journals (Sweden)

    M. Rashid Malik, Rekha Prasad

    2015-09-01

    Full Text Available This paper aims to examine the constraints and opportunities emerged for the Micro, small and medium enterprises in carpet industry after trade liberalization. The survey method was selected for this study. A structured questionnaire, containing both close and open ended questions was used for data collection. 65 carpet firms of Bhadohi District of Uttar Pradesh registered with All India Carpet Manufacture Association (AICMA were surveyed. Liberalization has brought many opportunities for carpet industry apart from challenges. Findings of the present study show that liberalization gave access to new markets and increased demand of products. Increased cost of raw material, difficulty in ‘export facilitation’ and ‘legal-regulatory framework and difficulty in procuring funds from local financial institutions were identified as the major constraints for the carpet industry.

  19. Review Article: Kneeling at the Altar of (Il-)liberalism

    DEFF Research Database (Denmark)

    Vanhuysse, Pieter

    2008-01-01

    of their second decade after communism, they have entered a second stage in the political dynamics of economic reforms. Unemployment and labor anger more generally have clearly not disappeared from the political scene in this stage. But, paradoxically, at a time when liberal forces were on the rise among...... erstwhile post-communist 'transition laggards' such as Georgia, Ukraine, and Croatia, many first-stage 'transition leaders' have experienced a turn in distinctly illiberal directions. Post-communism's economically liberal elites have achieved remarkable successes - peaceful democratic consolidation, fast...... market reforms, and EU membership. But they have paid a high price, in the form of lost voters (as politicians) and lost members (as union leaders). The silencing of organized labor and angry workers has accelerated the instauration of neo-liberal varieties of market capitalism and has contributed...

  20. Transnational pharmaceutical corporations and neo-liberal business ethics in India.

    Science.gov (United States)

    D'Mello, Bernard

    2002-03-01

    The author critiques the expedient application of market valuation principles by the transnational corporations and other large firms in the Indian pharmaceutical industry on a number of issues like patents, pricing, irrational drugs, clinical trials, etc. He contends that ethics in business is chiseled and etched within the confines of particular social structures of accumulation. An ascendant neo-liberal social structure of accumulation has basically shaped these firms' sharp opposition to the Indian Patents Act, 1970, government administered pricing, etc. The author contents that the practice of neo-liberal economics is strongly associated with a "one-dimensional" ethics that privileges market valuation principles over all others. This seems to inevitably generate a social counter-movement that struggles for social protections. He critiques neo-liberal business practices from a perspective that derives from the work of the economic anthropologist Karl Polanyi. Before the present phase of liberalization in India, markets were "managed", but without a "welfare state" in place. Moving toward deregulation of the markets without a welfare state in place is unethical. Keeping the debilities of the institutional framework of public policy in mind, the author adopts a Polanyian perspective that places its trust and hope in the growing social legitimacy of the counter-movement in opposition to both neo-liberal business practices and the degenerate behavior of state agencies.

  1. A New Accreditation Problem: Defining the Liberal Arts and Sciences.

    Science.gov (United States)

    Hoskins, Robert L.

    In 1985, the Accrediting Council on Education in Journalism and Mass Communications (ACEJMC) adopted a standard requiring that journalism/mass communications students take a minimum of 90 semester hours in courses outside their major, with at least 65 hours in liberal arts and sciences. The term "liberal arts" defies precise definition,…

  2. Effects Of Trade Liberalization Policy On The Performance Of Small ...

    African Journals Online (AJOL)

    The Majority of food processors (i.e. 94 %) were established after the introduction of trade liberalization policy in 1983, and about 67 % sourced raw materials locally and 55 % financed businesses from own savings and profits. The trade liberalization policy had a positive effect on the output growth of SMS food processing ...

  3. Liberalism: Notes on a Concept for Educators and Educational Researchers

    Science.gov (United States)

    Cooley, Aaron

    2009-01-01

    This paper investigates the history and concept of liberalism from its first uses to its most modern incarnations. The paper aims to serve as a primer for educators and educational researchers to better understand liberalism and its place as a foundational and controversial discourse in politics, social science, and education. Through reference to…

  4. European municipalities and the liberalized energy market

    International Nuclear Information System (INIS)

    2002-04-01

    Municipalities are directly affected by the liberalization of the energy markets. Because they all consume or even produce energy, whether it be for their own consumption or to resell it, they often distribute gas, electricity or heat, they plan urban areas and organize the energy networks on their territory, while in addition citizens expect municipalities to inform them and even protect them against the possible excesses of energy salesmen. Elected representatives administrations, local agencies, municipal companies, citizens' associations etc., all have to innovate. This supplement to Energie-Cites INFO is intended to provide you with practical information and further analyses of the liberalization process. (authors)

  5. The Gendered Labor Market Impacts of Trade Liberalization Evidence from Brazil

    NARCIS (Netherlands)

    Gaddis, Isis; Pieters, Janneke

    2017-01-01

    This paper investigates the impact of Brazil's trade liberalization on gender differences in labor market outcomes, using difference-in-difference estimation that exploits variation in preliberalization industry composition across microregions. We find that trade liberalization reduced male and

  6. [Influence of quaternary ammonium salt on liberation of drug with antiseptic effect].

    Science.gov (United States)

    Vitková, Zuzana; Herdová, Petra; Oremusová, Jarmila; Cižmárik, Jozef; Tóthová, Katarína

    2013-12-01

    The paper evaluates the influence of three surfactants (carbetopendecinium halogenides) on the liberation of the drug chlorhexidine dihydrochloride (CHX) in 0.1% (w/w) from the dosage form-gel and also the flow properties of gels. The following tensides were evaluated: carbetopendecinium bromide (SB), carbetopendecinium chloride (SC), and carbetopendecinium iodide (SI). The tenside concentration was set under the critical micelle concentration. The biopolymer - chitosan (CHIT) in 2.5% (w/w) concentration was used as a gel creating substance. Based on the flow properties of the studied gels, it was found that the employed tensides exhibited no influence on the character of the system. The gels exhibited the character of plastic systems with time-independent flow. The drug liberation was evaluated at the temperatures of 20, 30 and 40 °C. Between the types of the tensides, the statistically significant differences (P < 0.05) were found as to the amount of the liberated CHX, which was reflected by the increased amount of the liberated drug. Based on the obtained results, it can be concluded that the most suitable was the SI tenside. From the gel with this tenside the greatest amount of CHX was liberated, which had the highest value of the liberation rate constant.

  7. Procedure for recovery from an uranium containing concentrate and phosphoric acid, as well as an uranium containing concentrate and phosphoric acid obtained by this procedure

    International Nuclear Information System (INIS)

    1980-01-01

    The phosphate ore is dissolved in sulphuric acid and the formed calcium sulphate is separated from the solution. The uranium is then precipitated by adding ammonium fluoride solution to the remaining phosphoric acid solution. When the phosphate ore is dissolved in sulphuric acid, fluorine gas is liberated and this is then used to produce the ammonium fluoride solution. (Th.P.)

  8. RETHINKING LIBERAL DEMOCRACY: PRELUDE TO TOTALITARIANISM

    Directory of Open Access Journals (Sweden)

    Isabel David

    2015-04-01

    Full Text Available In the long course of human evolution and political experimentation, liberal democracy, especially after the events of 1989, has come to be seen as the best political system. In fact, we seemed to have reached the only system compatible with liberty, after the dreadful experiences of Communist and Nazi totalitarianism, and its twin in the economic realm - capitalism. But is liberalism really conducive to freedom? I argue that evil – or totalitarianism – arises from the combination of both the Platonic and Augustinian views: ignorance of values and the pursuit of one’s egotistic desires. Evil has an essentially private nature. In this sense, totalitarianism may arise from a utilitarian culture that sees people – or some forms of knowledge – as worthless and disposable objects.

  9. Liberalization turns energy market upside down

    International Nuclear Information System (INIS)

    Lousberg, H.H.J.

    2002-01-01

    The consequences of free energy trade are discussed, i.e. the changes caused by liberalization of the energy market. The ability to purchase energy freely, thus creating competition between sources of energy, is changing the relationships between gas and electricity prices. The implications are very significant for building services contractors and energy companies and also for the selection of technical concepts. It also, of course, has implications for the environment. liberalization also gives certain customers the opportunity to consider their energy supply on an integrated basis. Who is going to supply me with energy, rather than who supplies electricity and who supplies gas? For example, the customer wants heating, cooling and electricity, and the conversion methods are not immediately relevant. This creates the possibility of offering, or outsourcing, a total 'energy' package [nl

  10. A History of the Liberal Arts Computer Science Consortium and Its Model Curricula

    Science.gov (United States)

    Bruce, Kim B.; Cupper, Robert D.; Scot Drysdale, Robert L.

    2010-01-01

    With the support of a grant from the Sloan Foundation, nine computer scientists from liberal arts colleges came together in October, 1984 to form the Liberal Arts Computer Science Consortium (LACS) and to create a model curriculum appropriate for liberal arts colleges. Over the years the membership has grown and changed, but the focus has remained…

  11. Neo-Liberalism in British Columbia Education and Teachers' Union Resistance

    Science.gov (United States)

    Poole, Wendy

    2007-01-01

    Since the election of the Campbell government in 2001, teachers have experienced heightened conflict with the provincial government. An analysis of the discourse and power relations between the BC Teachers' Federation (BCTF) and government reveals a neo-liberal agenda on the part of government and anti-neo-liberalism on the part of the BCTF.…

  12. Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling.

    Science.gov (United States)

    Caires, Rebeca; Sierra-Valdez, Francisco J; Millet, Jonathan R M; Herwig, Joshua D; Roan, Esra; Vásquez, Valeria; Cordero-Morales, Julio F

    2017-10-03

    Dietary consumption of ω-3 polyunsaturated fatty acids (PUFAs), present in fish oils, is known to improve the vascular response, but their molecular targets remain largely unknown. Activation of the TRPV4 channel has been implicated in endothelium-dependent vasorelaxation. Here, we studied the contribution of ω-3 PUFAs to TRPV4 function by precisely manipulating the fatty acid content in Caenorhabditis elegans. By genetically depriving the worms of PUFAs, we determined that the metabolism of ω-3 fatty acids is required for TRPV4 activity. Functional, lipid metabolome, and biophysical analyses demonstrated that ω-3 PUFAs enhance TRPV4 function in human endothelial cells and support the hypothesis that lipid metabolism and membrane remodeling regulate cell reactivity. We propose a model whereby the eicosanoid's epoxide group location increases membrane fluidity and influences the endothelial cell response by increasing TRPV4 channel activity. ω-3 PUFA-like molecules might be viable antihypertensive agents for targeting TRPV4 to reduce systemic blood pressure. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  13. Trade liberalization and the diet transition: a public health response.

    Science.gov (United States)

    Rayner, Geof; Hawkes, Corinna; Lang, Tim; Bello, Walden

    2006-12-01

    Trade liberalization remains at the forefront of debates around globalization, particularly around the impact on agriculture and food. These debates, which often focus on how poorer countries can 'trade their way' out of poverty, pay limited attention to dietary health, especially in the light of the WHO's Global Strategy for Diet, Physical Activity and Health (2004), which warned that future health burdens will be increasingly determined by diet-related chronic diseases. This article examines the diet transition as the absent factor within debates on liberalizing trade and commerce. We describe the evolution of trade agreements, noting those relevant to food. We review the association between trade liberalization and changes in the global dietary and disease profile. We illustrate some of the complex linkages between trade liberalization and the 'diet transition', illustrated by factors such as foreign direct investment, supermarketization and cultural change. Finally, we offer three scenarios for change, suggesting the need for more effective 'food governance' and engagement by public health advocates in policy making in the food and agriculture arena.

  14. Effect of extra virgin olive oil components on the arachidonic acid cascade, colorectal cancer and colon cancer cell proliferation

    International Nuclear Information System (INIS)

    Storniolo, C.E.; Moreno, J.J.

    2016-01-01

    The mediterranean diet (MD) reduced the risk of colorectal cancer (CRC), and olive oil, the primary source of fat in the MD, has also been found to have a protective effect. However, animals fed with oleic acid present a high number of intestinal tumours, suggesting that oleic acid and olive oil consumption can exert different effects on CRC. Considering that extra virgin olive oil (EVOO) is a complex mix of fatty acids and minor compounds such as polyphenols, hydrocarbons, phytosterols and triterpenes; and that these compounds have antioxidant activity and consequently they can modulate the arachidonic acid (AA) cascade and eicosanoid synthesis. This review analyzes the state of the art of olive oil components on the AA cascade and cellular mechanism involved in CRC such as intestinal epithelial cell growth/apoptosis, to understand the fact that the consumption of seed oils with high oleic content or EVOO will probably have different effects on CRC development. [es

  15. Effect of extra virgin olive oil components on the arachidonic acid cascade, colorectal cancer and colon cancer cell proliferation

    Directory of Open Access Journals (Sweden)

    C. E. Storniolo

    2016-12-01

    Full Text Available The mediterranean diet (MD reduced the risk of colorectal cancer (CRC, and olive oil, the primary source of fat in the MD, has also been found to have a protective effect. However, animals fed with oleic acid present a high number of intestinal tumours, suggesting that oleic acid and olive oil consumption can exert different effects on CRC. Considering that extra virgin olive oil (EVOO is a complex mix of fatty acids and minor compounds such as polyphenols, hydrocarbons, phytosterols and triterpenes; and that these compounds have antioxidant activity and consequently they can modulate the arachidonic acid (AA cascade and eicosanoid synthesis. This review analyzes the state of the art of olive oil components on the AA cascade and cellular mechanism involved in CRC such as intestinal epithelial cell growth/apoptosis, to understand the fact that the consumption of seed oils with high oleic content or EVOO will probably have different effects on CRC development.

  16. Liberalization of electricity markets in Quebec and France: crossed prospects

    International Nuclear Information System (INIS)

    Caron, Jocelyn

    2011-01-01

    This essay focuses on the liberalization of electricity markets in Quebec and France. As in most Western states, Quebec and France have undertaken reforms to liberalize their domestic electricity markets. Starting from a similar arrangement, namely occupied by a state monopoly, the French and Quebecois markets have evolved into a more or less liberalized model. What were the changes brought about by these reforms? What reasons have motivated them? What is the functioning of the model in place in both states? What are the prospects for these markets? To identify the issues of these reforms, this essay will be divided into four chapters. The first chapter will discuss the organization of markets in Quebec and French before the liberalizing reforms: in addition to the organization as such, this chapter will address the reasons why the two states have chosen a market controlled by the state. It emerges from this chapter that both states nationalized and regulated the electricity market to promote economic development and quality standards for a service considered public. The second chapter will examine the genesis of liberalization reforms, the different models of market organization and a summary of selected experiences of liberalization that took place both before those of Quebec and France ones. The diversity of market models and the pitfalls have lived through some states raised the fact that successful liberalization reforms is a complex process. The third chapter will analyse the reforms that changed markets in Quebec and France and more specifically, the organization of the market that has resulted. It is established that if the two markets have been forced to reform themselves by forces outside the two states, the paths that were taken differ greatly. Finally, the fourth chapter will conduct an initial assessment of the reforms and provide some forecast for the future. The reforms that have taken place in both states have produced satisfactory results taking

  17. Career guidance for Social Justice in Neo-Liberal Times

    DEFF Research Database (Denmark)

    Thomsen, Rie; Skovhus, Randi Boelskifte; Sultana, Ronald

    SIMPOSIO 16. Career guidance for Social Justice in Neo-Liberal Times (English) Ronald Sultana (Coord.), Tristram Hooley (Coord.), Rie Thomsen, Peter Plant, Roger Kjærgård, Marcelo Afonso Ribeiro, Randi Boelskifte Skovhus and Tron Inglar......SIMPOSIO 16. Career guidance for Social Justice in Neo-Liberal Times (English) Ronald Sultana (Coord.), Tristram Hooley (Coord.), Rie Thomsen, Peter Plant, Roger Kjærgård, Marcelo Afonso Ribeiro, Randi Boelskifte Skovhus and Tron Inglar...

  18. Multiculturalism and the American Liberal Arts College: Faculty Perceptions of the Role of Pedagogy

    Science.gov (United States)

    Aleman, Ana M. Martinez; Salkever, Katya

    2004-01-01

    The incompatibility of American liberal education and multiculturalism ground this qualitative study. Given this assertion and that teaching and learning is central to the liberal educational mission, we explore faculty perceptions of the relationship between multiculturalism and liberal educational pedagogy. The findings of this study suggest…

  19. Dimension of Liberal Education in the Studies at a Technological University

    Directory of Open Access Journals (Sweden)

    Jolita Horbačauskienė

    2012-06-01

    Full Text Available The paper discusses the dimension of liberal education in the studies at a technological university emphasizing two aspects: socializing of studies of technical sciences and education of a professional – generalist. Liberal education in the studies at a technological university is regarded as a possibility to educate a professional with such abilities as communication skills, critical thinking, understanding of social context, professional ethics, scientific interest in professional development and motivation for further education. On the basis of the analysis of scientific literature, the paper presents theoretical model of liberal education in the studies at a technological university.

  20. Liberalism - neoliberalism - market fundamentalism: from the concept of freedom to the totalitarian dogma

    Directory of Open Access Journals (Sweden)

    V. I. Chelischev

    2016-01-01

    Full Text Available The article further describes the ideological, historical, socio-political and economic circumstances, responsible for the specific direction of a new form of the ideology of liberalism - contemporary liberalism (neo-liberalism. The special attention, along with the analysis of the ideas of the founder of original theory of the state intervention in the economic life of the society of John Maynard Keynes (1883-1946, is given to “neoliberal” economic constructions of an ideological orientation of Friedrich August von Hayek (1899-1992 and Milton Friedman (1912-2006, defenders of a liberal principle of self-regulation of economy, free from any regalements. The author, on the basis of the analysis of primary sources and examples from a political and social life of some States, shows that in theory the resurgence of liberalism in the form of neo-liberalism personified the idea of the priority of the individual to society and the State, the market - before planning and regulation, the human rights - before the power authority and the team. However in practice this revival was accompanied by displacement of accents and growth of ideological tendencies. Thus, theorists and practitioners of neo-liberalism lined up quite utopian model not only of economic, but also of social relations. Article details the mechanisms by which the theoretical constructions of economists-neoliberals were emasculated by politicians who gradually reduced them to the primitive and convenient theses, justifying any actions of the authorities. Over time, these points have become “undeniable truths”, through which neo-liberalism became dogmatic, and its economic credo has got obvious fundamentalist character, having turned to market dogma of totalitarian type.

  1. Liberalism, Radicalism, and Self-Governing Schools

    Science.gov (United States)

    Swartz, Ronald

    1978-01-01

    Contrasts Karl Popper's theory of social reform with a Marxist theory of reform. Concludes that a liberal approach to educational reform, as exemplified by A.S. Neill's self-governing school at Summerhill, is generally more satisfactory. (Author/DB)

  2. Dietary fatty acids and membrane protein function.

    Science.gov (United States)

    Murphy, M G

    1990-02-01

    In recent years, there has been growing public awareness of the potential health benefits of dietary fatty acids, and of the distinction between the effects of the omega6 and omega3 polyunsaturated fatty acids that are concentrated in vegetable and fish oils, respectively. A part of the biologic effectiveness of the two families of polyunsaturated fatty acids resides in their relative roles as precursors of the eicosanoids. However, we are also beginning to appreciate that as the major components of the hydrophobic core of the membrane bilayer, they can interact with and directly influence the functioning of select integral membrane proteins. Among the most important of these are the enzymes, receptors, and ion channels that are situated in the plasma membrane of the cell, since they carry out the communication and homeostatic processes that are necessary for normal cell function. This review examines current information regarding the effects of diet-induced changes in plasma membrane fatty acid composition on several specific enzymes (adenylate cyclase, 5'-nucleotidase, Na(+)/K(+)-ATPase) and cell-surface receptors (opiate, adrenergic, insulin). Dietary manipulation studies have demonstrated a sensitivity of each to a fatty acid environment that is variably dependent on the nature of the fatty acid(s) and/or source of the membrane. The molecular mechanisms appear to involve fatty acid-dependent effects on protein conformation, on the "fluidity" and/or thickness of the membrane, or on protein synthesis. Together, the results of these studies reinforce the concept that dietary fats have the potential to regulate physiologic function and to further our understanding of how this occurs at a membrane level.

  3. Augustine and the Liberal Arts

    Science.gov (United States)

    Kenyon, Erik

    2013-01-01

    In an early dialogue, "On Order", Augustine sets out a program for thinking about thinking. Through such reflections, students attain self-knowledge and prepare for philosophical inquiry. The liberal arts are useful for this project, insofar as they provide opportunities for thinking, yet they are not ultimately necessary. I suggest that "On…

  4. Liberalism and gender: a contextual persepctive

    Directory of Open Access Journals (Sweden)

    Soledad Escalante Beltrán

    2006-04-01

    Full Text Available This article contextually discusses the category of gender from a liberal perspective. The six sections of the study provide a deep criticism of the social sciences from a less rigid perspective in the handling of dichotomous and exclusionary categories such as masculine-feminine, rational-emotional, private-public, liberal-community, to mention some of the central issues raised by the various debates about gender. A comparative methodology is used to analyze authors such as Kolberg, Gilligan, Rawls and others. One of the principal conclusions reached in this study is that traditional theoretical schemes, still in use, impede achieving broader consensuses and delay the resolution of practical problems such as, in the Peruvian case, those resulting from the translation of the discourse of equity into actions and concrete daily practices that provide citizens true access to justice.

  5. Risk and investment management in liberalized electricity markets

    International Nuclear Information System (INIS)

    Lemming, J.

    2003-09-01

    Electricity markets around the world are currently undergoing a liberalization process that changes the way electricity is traded and priced as a commodity. The electricity system has unique technical characteristics and the importance of electricity in today's information society is significant. The liberalization will not change the fact that politicians and regulators will be held responsible for keeping electricity on reasonable costs. What changes is the tool used by regulators to accomplish this task. The introduction of competitive markets implies that market participants will be held financial responsible for their decisions. System operators remain responsible for the physical balancing, thus electricity markets will remain strongly regulated even after liberalization. The hypothesis of this thesis is that the relevance of financial tools for electricity market risk management depends critically on the technical characteristics of electricity assets and on the demands placed by the stakeholders in the electricity sector. In many cases such technical characteristics and stakeholder demands will imply a need for revised and renewed tools compared to those used for portfolios of financial assets. (BA)

  6. War, Power and Liberalism: the Politicization in the Work of Michel Foucault

    Directory of Open Access Journals (Sweden)

    Joaquín Fortanet

    2009-04-01

    Full Text Available This paper attempts to examine the analysis on liberalism that Michel Foucault developed during his last courses in the Collège de France. This analysis becomes a redefinition of the concept of power, understood as war, and a reflection on the concepts of security and population, by means of which the relation between war, power and liberalism offers a map of the present time, an age when the new rationalityof government can be defined as specifically liberal.

  7. The effect of financial liberalization on capital flight in African economies

    NARCIS (Netherlands)

    Lensink, B.W.; Hermes, C.L.M.; Murinde, V.

    In this paper we assess the effects of financial liberalization on capital flight in African economies. A portfolio model, in which capital flight is one of the assets, is estimated on a sample of nine African countries for 1970-91. The estimation results suggest that financial liberalization

  8. Liberal Arts Colleges and Good Practices in Undergraduate Education: Additional Evidence

    Science.gov (United States)

    Seifert, Tricia A.; Pascarella, Ernest T.; Goodman, Kathleen M.; Salisbury, Mark H.; Blaich, Charles F.

    2010-01-01

    Liberal arts colleges have prided themselves on providing students with a quality undergraduate education among a scholarly community who are interested in their holistic development. Past research has found students who attended liberal arts colleges more frequently experienced Chickering and Gamson's (1987, 1991) good practices in undergraduate…

  9. Population Policies and Education: Exploring the Contradictions of Neo-Liberal Globalisation

    Science.gov (United States)

    Bovill, Catherine; Leppard, Margaret

    2006-01-01

    The world is increasingly characterised by profound income, health and social inequalities (Appadurai, 2000). In recent decades development initiatives aimed at reducing these inequalities have been situated in a context of increasing globalisation with a dominant neo-liberal economic orthodoxy. This paper argues that neo-liberal globalisation…

  10. The Public Ethics of Sovereignty of Evil and Political Liberalism

    Directory of Open Access Journals (Sweden)

    Elvio Baccarini

    2012-01-01

    Full Text Available The paper debates the issue of the preventive procedural concept of politics versus the aspirational liberal concept of politics as discussed in Derek Edyvane's book Civic Virtue and the Sovereignty of Evil: Political Ethics in Uncertain Times. The author indicates the necessity to conceptually differentiate sovereign evils from universal evils, and offers a defense of the liberal concept of justice.

  11. Foreign direct investment and liberalization policies in Pakistan: An empirical analysis

    Directory of Open Access Journals (Sweden)

    Rana Ejaz Ali Khan

    2014-12-01

    Full Text Available To enhance the inflow of foreign direct investment (FDI and ultimately to increase the economic growth, the countries have implemented a variety of financial and trade liberalization policies in the last three decades. Pakistan also initiated such type of policies. This study makes an analysis of the impact of liberalization (financial and trade in Pakistan, on the inflow of FDI using the time series data of 1971–2009. The DF-GLS test is used to determine the level of integration, and autoregressive distributed lag model to examine the long-run relationship. The results indicate that liberalization indicators, like financial liberalization index and trade openness along with real interest rate, negatively affect the inflow of FDI in Pakistan. Tax revenue of product also negatively affects the FDI. On the other hand, the gross fixed capital formation, infrastructure, and inflation positively influence the FDI in Pakistan. The market size (proxied by real gross domestic product has shown insignificant effect on FDI.

  12. Liberal or restrictive fluid administration in fast-track colonic surgery

    DEFF Research Database (Denmark)

    Holte, K; Foss, N B; Andersen, J

    2007-01-01

    surgery were randomized to 'restrictive' (Group 1) or 'liberal' (Group 2) perioperative fluid administration. Fluid algorithms were based on fixed rates of crystalloid infusions and a standardized volume of colloid. Pulmonary function (spirometry) was the primary outcome measure, with secondary outcomes...... and complications were also noted. RESULTS: 'Restrictive' (median 1640 ml, range 935-2250 ml) compared with 'liberal' fluid administration (median 5050 ml, range 3563-8050 ml) led to significant improvement in pulmonary function and postoperative hypoxaemia. In contrast, we found significantly reduced...... concentrations of cardiovascularly active hormones (renin, aldosterone, and angiotensin II) in Group 2. The number of patients with complications was not significantly different between the groups [1 ('liberal' group) [corrected] vs 6 ('restrictive' group) [corrected] patients, P = 0.08]. CONCLUSIONS...

  13. A Neurology of the Conservative-Liberal Dimension of Political Ideology.

    Science.gov (United States)

    Mendez, Mario F

    2017-01-01

    Differences in political ideology are a major source of human disagreement and conflict. There is increasing evidence that neurobiological mechanisms mediate individual differences in political ideology through effects on a conservative-liberal axis. This review summarizes personality, evolutionary and genetic, cognitive, neuroimaging, and neurological studies of conservatism-liberalism and discusses how they might affect political ideology. What emerges from this highly variable literature is evidence for a normal right-sided "conservative-complex" involving structures sensitive to negativity bias, threat, disgust, and avoidance. This conservative-complex may be damaged with brain disease, sometimes leading to a pathological "liberal shift" or a reduced tendency to conservatism in political ideology. Although not deterministic, these findings recommend further research on politics and the brain.

  14. The 1980s financial liberalization in the Nordic countries

    OpenAIRE

    Honkapohja, Seppo

    2012-01-01

    The financial liberalization in the four Nordic countries (Denmark, Finland, Norway, and Sweden) that took place mostly in the 1980s led to a major financial crisis in three of those countries. The crises in Finland, Norway, and Sweden are among the deepest financial crises in advanced market economies since World War II. Denmark experienced some banking problems but managed to avoid a systemic crisis. This paper reviews the process of liberalization and discusses the reasons why Finland, Nor...

  15. Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease.

    Science.gov (United States)

    Mori, Trevor A

    2017-11-01

    Omega-6 (ω6) and omega-3 (ω3) fatty acids are two classes of dietary polyunsaturated fatty acids derived from linoleic acid (18:2ω6) and α-linolenic acid (18:3ω3), respectively. Enzymatic metabolism of linoleic and α-linolenic acids generates arachidonic acid (20:4ω6) and eicosapentaenoic acid (20:5ω3; EPA), respectively, both of which are substrates for enzymes that yield eicosanoids with multiple and varying physiological functions. Further elongation and desaturation of EPA yields the 22-carbon fatty acid docosahexaenoic acid (22:6ω3; DHA). The main dietary source of EPA and DHA for human consumption is fish, especially oily fish. There is considerable evidence that EPA and DHA are protective against cardiovascular disease (heart disease and stroke), particularly in individuals with pre-existing disease. ω3 Fatty acids benefit multiple risk factors including blood pressure, blood vessel function, heart function and blood lipids, and they have antithrombotic, anti-inflammatory and anti-oxidative actions. ω3 Fatty acids do not adversely interact with medications. Supplementation with ω3 fatty acids is recommended in individuals with elevated blood triglyceride levels and patients with coronary heart disease. A practical recommendation for the general population is to increase ω3 fatty acid intake by incorporating fish as part of a healthy diet that includes increased fruits and vegetables, and moderation of salt intake. Health authorities recommend the general population should consume at least two oily fish meals per week. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Preference Erosion and Multilateral Trade Liberalization

    NARCIS (Netherlands)

    J.F. François (Joseph); B. Hoekman (Bernard); M. Manchin (Miriam)

    2005-01-01

    textabstractBecause of concern that OECD tariff reductions will translate into worsening export performance for the least developed countries, trade preferences have proven a stumbling block to developing country support for multilateral liberalization. We examine the actual scope for preference

  17. Mobile Technology and Liberal Education

    Science.gov (United States)

    Rossing, Jonathan P.

    2012-01-01

    In this article, the author offers reflections on the impact of mobile technology for liberal education. These reflections are based on his own experience of incorporating iPads in his communication courses during the 2010-2011 academic year. As a member of an interdisciplinary faculty learning community on the use of mobile tablets, he explored…

  18. National Institute for Technology in Liberal Education: An Assessment. White Paper

    Science.gov (United States)

    Brodeur, Jason; Daniels, Morgan; Johnson, Annie; Nicholls, Natsuko; Pickle, Sarah; Waraksa, Elizabeth A.

    2016-01-01

    In 2001, the National Institute for Technology in Liberal Education (NITLE) was created to "stimulate collaboration between selected liberal arts colleges and to act as a catalyst for the effective integration of emerging and newer digital technologies into teaching, learning, scholarship, and information management." In July 2015, NITLE…

  19. Sociopolitical Development and Political Activism: Synergies between Feminist and Liberation Psychology

    Science.gov (United States)

    Moane, Geraldine

    2010-01-01

    Feminist and liberation psychologies have emerged in contexts of marginalization and oppression and have developed in diverse, and sometimes synergistic, ways. I identify key themes for fostering critical consciousness and political action that arise from the intersections of feminist and liberation psychology. These themes include the need for…

  20. Theory of Patronized Goods. Liberal Evolution of Paternalism

    Directory of Open Access Journals (Sweden)

    Rubinstein Aleksandr Yakovlevich

    2016-06-01

    Full Text Available The neo-classical principles of rational behavior are considered in the context of the nature of paternalism as the basis of the Theory of patronized goods. The formation of society’s normative interests is discussed in concern of political aspects. The article illustrates the theoretical and the practical aspects of the concept of consociation democracy, providing liberalization of the institutions for making political and economic decisions. The results of analysis reveal a pattern of paternalism drifting towards institutional liberalization. Proposed a hypothesis explaining why the economic policy in modern Russia still remains somewhere between archaic and merit paternalism.

  1. Pedagogy of the Consumer: The Politics of Neo-Liberal Welfare Reform

    Science.gov (United States)

    Wilkins, Andrew

    2012-01-01

    Situated against the backdrop of a widespread and growing interest in the linkages between neo-liberalism and welfare, this paper introduces the lens of neo-liberalism as a conceptual strategy for thinking about contemporary issues in education policy. Through charting the historic rise of unfettered market institutions and practices in the…

  2. A Politically Liberal Conception of Formal Education in a Developing Democracy

    Science.gov (United States)

    Çelik, Rasit

    2016-01-01

    As discussed by John Rawls, in a well-ordered society, a public political culture's wide educational role bears the primary responsibility for developing reasonable individuals for the stability of a politically liberal society. Rawlsian scholars have also focused on the stability and enhancement of developed liberal democratic societies by means…

  3. The ESA/ESO/NASA Photoshop fits Liberator Version 2

    Science.gov (United States)

    Christensen, L. L.; Nielsen, L. H.; Nielsen, K. K.; Johansen, T.

    2005-12-01

    Since the fi rst version of the FITS Liberator software was released on the 8th July 2004 more than 50,000 people worldwide have looked over the scientists' shoulders and worked with digital images from telescopes in space and on the ground themselves. In this way the Liberator has become the `industry standard' for the production of astronomical colour images. The new version 2 of the software has recently been released and opens up a signifi cant number of new possibilities.

  4. Liberal Party Politics, the South African War, and the Rhetoric of Imperial Governance.

    Science.gov (United States)

    Mackley, Simon

    2018-03-01

    This article examines the imperial rhetoric of the Liberal Party during the South African War of 1899-1902, charting its use and development across five key controversies spanning the course of the conflict. Moving beyond traditional interpretations of the Liberal split as the product of competing visions of Empire and approaches to imperialism, this article argues for the need to recognize also the continuities within the imperial rhetoric of fin-de-siècle British Liberalism. Building on recent studies of political languages, it identifies how Liberal speakers from across the party operated within a rhetorical framework that emphasized three ideals of imperial governance: good government, self-government, and pluralism. In doing so, this article seeks to advance our understanding of the South African War as an episode in British party politics, demonstrating the complexity and nuance of the Liberal Party's response to the conflict. Furthermore, by undertaking an in-depth exploration of the rhetoric of imperial governance, this article highlights the Liberal response to the South African War as a case study for the reinvention and reiteration of both party and imperial languages in early twentieth-century Britain, with the potential to offer new insights into the political and imperial cultures of the period.

  5. Liberal CSR and New Marxist Criticism

    DEFF Research Database (Denmark)

    Toft, Kristian Høyer

    2014-01-01

    The term ‘corporate social responsibility’ (CSR) is considered by the new Marxist left to be a self-defeating oxymoron. In this chapter, the new Marxist challenge to CSR as a meaningful, coherent concept and practice is discussed. In the wake of the financial crisis the critique from the Marxist......-inspired left tends to replace the scepticism of the libertarian right (Friedman 1970). The legitimacy of business in society is at stake, and the critical left is well placed to debunk the integrity of business’s claim to social responsibility. To provide an overview of current Marxist inspired CSR thinking......, this chapter introduces the Hegelian inspired critique of a New Spirit of Capitalism (Chiapello 2013) as well as the critique of ideology targeted at the neo-liberal project of corporate responsibility (Žižek 2008; Fleming and Jones 2013). Subsequently, two possible liberal ‘revisions’ to the Marxist inspired...

  6. Financial Liberalization and Banking Profitability: a Panel Data analysis for Tunisian Banks

    Directory of Open Access Journals (Sweden)

    Hakimi Abdelaziz

    2011-01-01

    Full Text Available The financial liberalization policy was undertaken in several countries like in Tunisia in order to have modern and dynamic financial system. However, the consequences of this program are completely divergent from it’s waitings. In this paper, on the basis of data relating to 9 Tunisian banks over the period 1980-2009, and by adopting the panal data analysis, we will try to check the effect of financial liberalization on the Tunisian banking profitability. The results of our study show a negative and significative relation between financial liberalization and banking profitability.

  7. Conservatism and liberalism predict performance in two nonideological cognitive tasks.

    Science.gov (United States)

    Bernabel, Rodolpho Talaisys; Oliveira, Amâncio

    2017-01-01

    Intuitive thinking would argue that political or ideological orientation does not correlate with nonpolitical decisions, and certainly not with nonideological cognitive tasks. However, that is what happens in some cases. Previous neuropolitics studies have found that liberals are more adept at dealing with novel information than conservatives. This finding suggests that conservatives and liberals possess different cognitive skills. For the purposes of this article, two studies were executed to test whether this difference remained in alternative environmental settings. To this end, two novel cognitive tasks were designed in which one type of ideology or another was privileged according to the cognitive environment created by the tasks. Experimental findings indicate that liberals committed fewer errors than conservatives in one kind of cognitive environment, while conservatives scored higher in another.

  8. Recognizing and coping with our own prejudices: Fighting liberal bias without conservative input.

    Science.gov (United States)

    Baumeister, Roy F

    2015-01-01

    This commentary summarizes my struggle to overcome liberal bias without conservative input. I generally assume I am biased and constantly try to build a good-quality argument for the opposite view. Trying to dispense with one's liberal values can help, if one is willing. Frequent self-tests help. Liberal biases include race, gender, and poverty, but also dislike of business corporations and even Western civilization. Feminism is the single strongest and most powerful bias.

  9. Liberal vs Liberating Empowerment: A Latin American Feminist Perspective on Conceptualising Women's Empowerment

    OpenAIRE

    Sardenberg, Cecília Maria Bacellar

    2008-01-01

    Paper prepared for presentation to the Conference: Reclaiming Feminism – Gender and Neo-Liberalism, Institute of Development Studies (IDS), Brighton, UK, 9-10 July 2007. A previous version of this paper was presented at the Pathways of Women’s Empowerment Research Programme Consortium Inception Workshop, Luxor, Egypt, September 2006. The term ‘women’s empowerment’ is viewed with a certain amount of distrust by feminists in Latin America. There has been some ambiguit...

  10. 1986 POLICY: BEGINNING OF NEO-LIBERAL AGENDA

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics... VIOLATED THE CONSTITUTIONAL PRINCIPLES OF. EQUALITY & SOCIAL JUSTICE.. INTRODUCED A SOCIO-POLITICAL FAULT FOR NEO-LIBERAL FORCES TO PROMOTE PRINCIPLE OF PARALLEL STREAMS.

  11. Teaching Programming to Liberal Arts Students

    DEFF Research Database (Denmark)

    Andersen, Peter Bøgh; Bennedsen, Jens; Brandorff, Steffen

    2003-01-01

    In this paper we present a new learning environment to be used in an introductory programming course for studentsthat are non-majors in computer science, more precisely formultimedia students with a liberal arts background. Media-oriented programming adds new requirements to thecraft of programmi...

  12. Evaluating Liberal Learning: Doubts and Explorations.

    Science.gov (United States)

    Green, Thomas F.

    1982-01-01

    In current evaluation practice, the implicit philosophy of value, appraisal, and action is seen as a form of Benthamite utilitarianism. A domain of value called "educational worth" is described. Ways of detecting the presence of educational worth in liberal learning programs are identified. (MLW)

  13. September 11, Neo-liberalism and Discourse

    DEFF Research Database (Denmark)

    Holmgreen, Lise-Lotte

    2006-01-01

    of British financial news reports is analysed. This corpus covers the two-month period before and after the September-11 attacks and illustrates the extent to which economic ideology (neo-liberalism) and socio-economic change (the terrorist attacks) influence the choice of metaphor, and hence...

  14. The implication of omega-3 polyunsaturated fatty acids in retinal physiology

    Directory of Open Access Journals (Sweden)

    Acar Niyazi

    2007-05-01

    Full Text Available Neuronal tissues such as the retina and the brain are characterized by their high content in phospholipids. In the retina, phospholipids can account for until 80% of total lipids and are mainly composed by species belonging to phosphatidyl-choline and phosphatidyl-ethanolamine sub-classes. Within fatty acids esterified on retinal phospholipids, omega-3 PUFAs are major components since docosahexaenoic acid (DHA can represent until 50% of total fatty acids in the photoreceptor outer segments. For long time, DHA is known to play a major role in membrane function and subsequently in visual processes by affecting permeability, fluidity, thickness and the activation of membrane-bound proteins. Today, more and more studies show that PUFAs from the omega-3 series may also operate as protective factors in retinal vascular and immuno-regulatory processes, in maintaining the physiologic redox balance and in cell survival. They may operate within complex systems involving eicosanoids, angiogenic factors, inflammatory factors and matrix metalloproteinases. This new and emerging concept based on the interrelationship of omega-3 PUFAs with neural and vascular structure and function appears to be essential when considering retinal diseases of public health significance such as age-related macular degeneration.

  15. Understanding customer switching behavior in a liberalizing Service market : An exploratory study

    NARCIS (Netherlands)

    Wieringa, Jaap E.; Verhoef, Peter C.

    In recent decades, many service markets have been liberalized, which means incumbent service firms face new competitors and must address customer switching-which from a public policy perspective, is necessary to ensure that liberalization succeeds. In this article, the authors conduct an exploratory

  16. Understanding customer switching behavior in a liberalizing Service market : An exploratory study

    NARCIS (Netherlands)

    Wieringa, Jaap E.; Verhoef, Peter C.

    2007-01-01

    In recent decades, many service markets have been liberalized, which means incumbent service firms face new competitors and must address customer switching-which from a public policy perspective, is necessary to ensure that liberalization succeeds. In this article, the authors conduct an exploratory

  17. Objectifying or Liberating? Investigation of the Effects of Sexting on Body Image.

    Science.gov (United States)

    Liong, Mario; Cheng, Grand H-L

    2018-03-09

    Scholars are divided as to whether sexting-an unprecedented sexual activity using digital media-is objectifying or sexually liberating. One notion is that sexting involves the representation of an individual's sexuality in the presence of others and thus reinforces objectification. Another perspective contends that the self-portrayal of the body in sexting facilitates the exploration of sexual subjectivity and is, therefore, sexually liberating. By testing a model of sexting, objectified body consciousness (body surveillance, body shame, and body control beliefs), and comfort with nudity (indicator of sexual liberation) on 361 college students in Hong Kong, the current study revealed that, across genders, sexters demonstrated higher levels of body surveillance, body shame, and comfort with nudity than nonsexters. The results suggest that sexting is both sexually objectifying and liberating and that it has opened up a new sexual arena that combines sexual objectification and empowerment.

  18. Influence of liberation of sulphide minerals on flotation of sedimentary copper ore

    Directory of Open Access Journals (Sweden)

    Bakalarz Alicja

    2017-01-01

    Full Text Available Ore liberation is one of the most important parameter in mineral processing, especially in flotation. To separate the valuable components from gangue minerals, it is necessary to liberate one from others. It is achieve primarily through crushing and grinding. These stages are one of the most expensive of mineral production. It is important to determine the adequate mineral liberation which would result in huge savings in the overall cost of flotation plant. The aim of the paper was the analysis of the influence of milling time on the laboratory flotation of the copper ore from stratiform Polish deposit. Three different milling time of copper ore in laboratory ball mill was applied. The flotation results were presented as the recovery-recovery and grade-recovery upgrading curves. The liberation of sulphides and the particle size of sulphides in flotation product were analysed and compared.

  19. Environmental politics in the 1990s: The tension between liberalism and environmental quality

    International Nuclear Information System (INIS)

    Cahn, M.A.

    1991-01-01

    There are two structural tensions between liberalism and environmental quality. First, liberalism's emphasis on individual self-interest creates a problematic concept of communal good. Society, as manifest in liberal contract theory, exists not to find some higher good, but to protect individual rights. Individual and corporate property rights have consistently overshadowed community claims on resource management. Second, capitalism has been characterized by a constant drive for expansion in search of increased productivity and profit. The impact of that expansionary ethic has been overuse of limited resources and the poisoning of the physical environment. This study combines normative theory with case studies of the substantive policy areas of air, water, and waste. Environmental policy's analyzed with attention to the parameters of American political culture and the inherent limitations the language of liberalism places on policy choices. The literature on symbolic policy is then applied exploring the role of symbolic politics in easing the tension between liberalism and environmental quality. Ultimately, substantive policy areas are explored in a effort to explain the evolution of specific policies

  20. Liberalism is always greener on the other side of Mill: a reply to Piers Stephens

    NARCIS (Netherlands)

    Wissenburg, M.L.J.

    2001-01-01

    Given our shared interest in giving green political thought a basis in liberalism, I discuss five of Piers Stephens' objections to Green Liberalism. (1) I deny that I use preferences as black boxes, prejudicing liberalism in favour of a human-nature divide. (2) I argue that my characterisation of

  1. Education for Liberal Democracy: Fred Clarke and the 1944 Education Act

    Science.gov (United States)

    Ku, Hsiao-Yuh

    2013-01-01

    Fred Clarke (1880-1952), an English educationist, emerged as a leading figure with his liberal approach alongside such key figures as R. H. Tawney and Cyril Norwood in the reform leading to the 1944 Education Act. Many of his reform proposals, which were provided by the new Act, reflected his ideals of liberal democracy. Nevertheless, his…

  2. A comparative study: Difference in omega-6/omega-3 balance and saturated fat in diets for Atlantic salmon (Salmo salar) affect immune-, fat metabolism-, oxidative and apoptotic-gene expression, and eicosanoid secretion in head kidney leukocytes.

    Science.gov (United States)

    Holen, Elisabeth; Araujo, Pedro; Sissener, Nini H; Rosenlund, Grethe; Waagbø, Rune

    2018-01-01

    The aim of this study was to compare how different dietary vegetable oil n-6/n-3 ratios affect gene responses involved in inflammation, signaling pathways, fatty acid synthesis and oxidation, oxidation and apoptosis as well as eicosanoid production in salmon head kidney tissues and isolated head kidney leukocytes. Salmon smolts (200 g) were fed four different diets where the main lipid components were palm oil (n-6/n-3 ratio = 0.7), rapeseed oil (n-6/n-3 ratio = 0.9), and soybean oil (n-6/n-3 ratio = 2.4) and a high soybean oil diet with an n-6/n-3 ratio = 4. Both head kidney tissue and leukocytes isolated from head kidneys were sampled from the four diets, but from different fish. Leukocytes isolated from the head kidneys were seeded into culture wells and added lipopolysaccharide (LPS) to induce inflammatory responses. Controls without LPS were included. Head kidney leukocytes and the tissues should have the same phenotype reflecting the different diets. Interleukin 1β (IL-1β) transcription was elevated in head kidney tissue and especially in LPS treated leukocytes isolated from soybean oil (n-6/n-3 = 2.4) fed salmon, which confirmed the suitability of the in vitro model in this experiment. Leukocytes, treated with LPS, and isolated from salmon fed the soybean oil diet (n-6/n-3 = 2.4) also upregulated tumor necrosis factor alpha (tnf-α), cyclooxygenase (cox2), prostaglandin D and E synthase (ptgds, ptges), fatty acyl synthase (fas), 5 and 6 desaturases (5des, 6 des) and a fatty acid translocase protein (cd36) when compared to the other diets. The results suggest that diets with a specific n-6/n-3 ratio influence the transcription of pro-inflammatory genes and may be cross-linked to transcription of selected fatty acid metabolism genes. Salmon fed the palm oil diet (n-6/n-3 = 0.7) showed a lower expression of inflammatory genes. Instead, peroxisome proliferator activated receptor β1 (pparβ1), acyl coenzyme A (aco), apoptosis regulator (bax) and

  3. FCJ-147 Liberation Technology and the Arab Spring: From Utopia to Atopia and Beyond.

    Directory of Open Access Journals (Sweden)

    Ulises A. Mejias

    2012-07-01

    Full Text Available While the tendency in the West to refer to the Arab Spring movements as ‘Twitter Revolutions’ has passed, a liberal discourse of ‘liberation technology’ (information and communication technologies that empower grassroots movements continues to influence our ideas about networked participation. Unfortunately, this utopian discourse tends to circumvent any discussion of the capitalist market structure in which these tools operate. In this paper, I suggest that liberation technologies may in fact increase opportunities for political participation, but that they simultaneously create certain kinds of inequalities. I end by proposing a theoretical framework for locating alternative practices of participation and liberation.

  4. Holography as a Liberal Arts Physics Course

    Science.gov (United States)

    Huang, Jacob Wen-kuang

    1978-01-01

    Describes a liberal arts physics course for all majors interested in holography or to satisfy the general education requirements. An outline of the course and some experience of offering it are given. (Author/GA)

  5. Suppliers response to liberalization in Europe

    International Nuclear Information System (INIS)

    Boon Von Ochssee, T.

    2007-03-01

    Current EU target of achieving a fully liberalized internal market today does not guarantee the availability of volumes tomorrow. Europe will have to compete with other markets, such as the US in the Atlantic Basin and perhaps the Pacific Basin in the future as far as LNG is concerned. Thus, it is against the backdrop of scarcity in a seller's market that Europe's security of supply must be perceived in the period leading up to 2010, 2020 and beyond. Nevertheless, the focus of Europe's energy concerns will lay with internal developments, primarily competition, unbundling and the ostensible development of an increased share of sustainable energy mix by 2020. Whether the European Commission's ultimate goal, a transparent and completely liberalized gas network system, will be supplied with the necessary volumes to sustain demand growth is another matter. This article seeks to shine the limelight on the external aspects of the EU energy dimension.

  6. Liberation and dependency: a theological reading of social sciences in Latin America

    Directory of Open Access Journals (Sweden)

    Teixeira, Helio Aparecido Campos

    2015-08-01

    Full Text Available Introduction: In the early 1970s, social movements directed Latin American theologyto a creative process of deprivatization of the Christian faith, reconfiguring fromthe community practices of liberation and their holistic implications the theoreticalexercise concerning its political and social commitment. Consequently, the notion ofliberation began to be addressed by the opposite equivalent of dependency withinthe methodological framework of the biblical-theological approach. Objective: Tounderstand the meaning of the opposite correlation between liberation and dependencyfrom their specificities in accordance with the vision of liberation intellectuals,and identify the way in which dependency was appropriate to respond to theresponsive and socio-analytical theoretical framework of these intellectuals, linkingthe reading of reality to the Latin American community practice. Methods: Historicaland systematic research, exploratory, under an analytical-descriptive orientation, organized from conceptual schemes. Results: Based on the finding regarding the theoretical refraction of dependency through liberation, the concept emerges as thetheological interpretation of an entire theoretical field taken indistinctly, namely theDependency Theory. Conclusion: The opposite correlation between dependency andliberation as a finding that reveals the similarity between the real that is theorized(dependency and the hypothetical conceptualization of maxims of action (liberation,comprehended within the general theory of anti-imperialism, resulted in aninterdisciplinary theological reflection.

  7. Socio-philosophical background (the theoretical core of classical liberalism

    Directory of Open Access Journals (Sweden)

    N. G. Osipova

    2015-01-01

    Full Text Available In the present article the theoretical core of classical liberalism are revealed through a systematic analysis of the views of social scientists as J. Locke, J. Bentham, J.S. Mill, A. Tocqueville and A. Smith about the nature of relations between the individual and society, individual freedom, an ideal socio-political order and its economic fundamentals and principles of governance. The author in details analyses the genesis and content of the aggregate set of values of classical liberalism, such as individualism, freedom, reason, justice, tolerance, and private property.

  8. A way of Dukovany NPP to privatization and liberalized market

    International Nuclear Information System (INIS)

    Kouklik, I.

    2001-01-01

    This presentation describes the current situation in the Dukovany NPP with two main upcoming future phenomena - privatization of CEZ company and preparation for liberalized electricity market. Considerations about level of safety, investment costs and competitiveness of Dukovany Nuclear Power Plant in liberalization process is described together with a comparison of some safety features of the world's NPPs. Results of this comparison are used for consideration and evaluation of some require modifications effectiveness. (author)

  9. À propos de The Practice of Liberal Pluralism de William Galston : un dialogue avec l’auteur

    Directory of Open Access Journals (Sweden)

    Roberto Merrill

    2006-05-01

    Full Text Available The publication of "The Practice of Liberal Pluralism" by Willam Galston has appeared as an event of first importance regarding contemporary theory about the relation between pluralism and liberalism. William Galston’s theory has had a visible evolution: in "Liberal Purposes", the main object is a critique of neutralism and a defence of perfectionist liberalism, whereas "Liberal Pluralism" main concern was to draw the limits of state intervention. This evolution is the object of numerous questions in the following discussion. "The Practice of Liberal Pluralism" operates an interesting synthesis on this point. Galston defines himself as a liberal pluralist such as Berlin, but although he acknowledges that conflict between values can be tragic, he minimizes this aspect in the following discussions, and considers the possibility of having prima facie duties (cf. the discussion on his rejection of moral particularism. One of the main arguments for the defence of value pluralism is its capacity to explain the complexity of the moral universe (cf. the discussion on pluralism and regret. Galston endorses a political pluralism, which means that the sources of authority are multiple. Galston’s liberalism is very tolerant regarding non-liberal communitarian practices, although this tolerance is based on the defence of an exit right, which is a fundamental notion in his theory. In the following discussion, Galston proposes how to understand this right of exit in an adequate manner (cf. the questions regarding expressive liberty, exit rights and autonomy.

  10. In vitro liberation of carotenoids from spinach and Asia Salads after different domestic kitchen procedures

    DEFF Research Database (Denmark)

    Eriksen, Jane Nygaard; Luu, Amy; Dragsted, Lars Ove

    2016-01-01

    -carotene liberation from spinach and Asia salads by applying an in vitro digestion protocol and UHPLC analysis. Reduction of particle size resulted in a three- to fourfold increase in liberation of lutein and β-carotene when comparing whole leaf and puree preparations of spinach. However, this positive effect...... was shown to be nullified by the severe heat impact during stir-frying of minced spinach, showing that domestic treatments need to be chosen carefully to maximise carotenoid liberation. Steaming significantly improved lutein liberation from Asia salads, but had no or a negative effect in spinach samples...

  11. Stakeholders' expectations and perceived effects of the pharmacy ownership liberalization reform in Sweden

    DEFF Research Database (Denmark)

    Wisell, Kristin; Winblad, Ulrika; Sporrong, Sofia Kälvemark

    2016-01-01

    were developed in an inductive manner. RESULTS: One expectation among the political organization participants was that the ownership liberalization would create opportunities for ideas. The competition introduced in the market was supposed to lead to a more diversified pharmacy sector. After......BACKGROUND: Reforms in the health-care sector, including the pharmacy sector, can have different rationales. The Swedish pharmacies were prior to 2009 organized in a state-owned monopoly. In 2009, a liberalization of the ownership took place, in which a majority of the pharmacies were sold...... to private owners. The rationales for this liberalization changed profoundly during the preparatory work, making it probable that other rationales than the ones first expressed existed. The aim of this study was to explore the underlying rationales (not stated in official documents) for the liberalization...

  12. Structural Liberalism and Anti-Bullying Legislation

    Science.gov (United States)

    Vaught, Sabina E.

    2014-01-01

    This article investigates the legal, semantic, and material implications of Massachusetts' anti-bullying law through an analytic framework of structural liberalism. Specifically, this article asks how the law produces categories of fit and unfit subjects of the state through raced and gendered practices of individualism, paternalism, meliorism,…

  13. The strange birth of liberal Denmark

    DEFF Research Database (Denmark)

    Henriksen, Ingrid; Sharpe, Paul; Lampe, Markus

    2012-01-01

    into decline, in fact flourished. Key to the success of Danish agriculture was an early diversification towards dairy production. This article challenges this simple story which sees Denmark as something of a liberal paragon. Denmark's success owed much to a prudent use of trade policy which favoured dairy...

  14. A state of limbo: the politics of waiting in neo-liberal Latvia.

    Science.gov (United States)

    Ozoliņa-Fitzgerald, Liene

    2016-09-01

    This article presents an ethnographic study of politics of waiting in a post-Soviet context. While activation has been explored in sociological and anthropological literature as a neo-liberal governmental technology and its application in post-socialist context has also been compellingly documented, waiting as a political artefact has only recently been receiving increased scholarly attention. Drawing on ethnographic fieldwork at a state-run unemployment office in Riga, this article shows how, alongside activation, state welfare policies also produce passivity and waiting. Engaging with the small but developing field of sociological literature on the politics of waiting, I argue that, rather than interpreting it as a clash between 'neo-liberal' and 'Soviet' regimes, we should understand the double-move of activation and imposition of waiting as a key mechanism of neo-liberal biopolitics. This article thus extends the existing theorizations of the temporal politics of neo-liberalism. © London School of Economics and Political Science 2016.

  15. Economic Effects of Russia’s Trade Liberalization: Russia’s WTO Accession and FTAs with EU and Korea

    Directory of Open Access Journals (Sweden)

    Chang-Soo Lee

    2008-06-01

    Full Text Available This paper estimates the economic impacts of the various liberalization scenarios of Russia (accession to the WTO, Russia-EU FTA, and Korea-Russia FTA using GTAP recursive dynamic and capital accumulation models. To compare liberalization gains from goods liberalization with those from goods-and-services liberalization, the original GTAP database is adjusted by inputting Australian sectoral indices as barriers in the service trade. The major findings and implications of this paper are as follows. First, without simultaneous improvement of market institutions, Russia's liberalization gains from its accession to the WTO are not so great. Second, the inclusion of the services sector in addition to the goods sector in the WTO liberalization scenarios does not greatly expand Russia's economic benefits from trade. This is quite different from the case of China's accession to the WTO. Third, Russia's liberalization gains from the Russia-EU FTA are not so great, either. This result is in contrast to that of CEEC's accession to the EU, where the CEEC enjoys large gaThis paper estimates the economic impacts of the various liberalization scenarios of Russia (accession to the WTO, Russia-EU FTA, and Korea-Russia FTA using GTAP recursive dynamic and capital accumulation models. To compare liberalization gains from goods liberalization with those from goods-and-services liberalization, the original GTAP database is adjusted by inputting Australian sectoral indices as barriers in the service trade. The major findings and implications of this paper are as follows. First, without simultaneous improvement of market institutions, Russia's liberalization gains from its accession to the WTO are not so great. Second, the inclusion of the services sector in addition to the goods sector in the WTO liberalization scenarios does not greatly expand Russia's economic benefits from trade. This is quite different from the case of China's accession to the WTO. Third, Russia

  16. Quantitative profiling of oxylipins through comprehensive lc-ms/ms analysis: Application in cardiac surgery

    Science.gov (United States)

    Oxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also referred to as lipid mediators, are (non-) enzymatically generated by oxidation of polyunsaturated fatty acids such as arachidonic acid (AA). A...

  17. Lipid-binding proteins modulate ligand-dependent trans-activation by peroxisome proliferator-activated receptors and localize to the nucleus as well as the cytoplasm

    DEFF Research Database (Denmark)

    Helledie, T; Antonius, M; Sorensen, R V

    2000-01-01

    Peroxisome proliferator-activated receptors (PPARs) are activated by a variety of fatty acids, eicosanoids, and hypolipidemic and insulin-sensitizing drugs. Many of these compounds bind avidly to members of a family of small lipid-binding proteins, the fatty acid-binding proteins (FABPs). Fatty...

  18. A Study on improvement of comprehensive environmental management system - activation of liberalized environmental management

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Hweu Sung; Kang, Chul Goo [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    As a part of improvement on a comprehensive environmental management system, this study was attempted to find an activating policy for a liberalized environmental management. This study provided an activation plan of reasonable environmental regulation reform and liberalized environmental management through the analysis of foreign examples and domestic situation. Furthermore, it analyzed an institutional mechanism for a smooth operation of liberalized environmental management. 68 refs., 5 figs., 51 tabs.

  19. mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.

    Science.gov (United States)

    De Armas, Rafael; Durand, Karine; Guillaudeau, Angélique; Weinbreck, Nicolas; Robert, Sandrine; Moreau, Jean-Jacques; Caire, François; Acosta, Gisela; Pebet, Matias; Chaunavel, Alain; Marin, Benoît; Labrousse, François; Denizot, Yves

    2010-07-01

    Gliomas are tumors of the central nervous system derived from glial cells. They show cellular heterogeneity and lack specific diagnostic markers. Although a possible role for the eicosanoid cascade has been suggested in glioma tumorigenesis, the relationship between enzymes and receptors implicated in arachidonic acid metabolism, with histological tumor type has not yet been determined. Quantitative real-time reverse transcription-polymerase chain reaction was performed to measure and compare transcript levels of enzymes and receptors implicated in both lipoxygenase and cyclooxygenase pathways between oligodendrogliomas, astrocytomas, glioblastomas and mixed oligoastrocytomas. Arachidonic acid metabolism-related enzymes and receptor transcripts (i) were underexpressed in classical oligodendrogliomas compared to astrocytomas and/or glioblastomas, (ii) differed between astrocytomas and glioblastomas and (iii) had an intermediate expression in mixed oligoastrocytomas. mRNA levels of enzymes and receptors implicated both in lipoxygenase and cyclooxygenase pathways differed significantly in gliomas according to the histological type. Copyright 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  20. Neo-liberalism, Crisis and the Contradictions of Depoliticisation

    Directory of Open Access Journals (Sweden)

    Peter Burnham

    2017-10-01

    Full Text Available This paper develops a political economy analysis of depoliticisation in the context of the crisis of neo-liberalism in Western Europe. Following a discussion of the theoretical foundations of the concept, it emphases that whilst depoliticisation strategies are often associated with neo-liberalism, such strategies have a longer trajectory existing even within Keynesian regimes. The paper then details the many forms taken by depoliticisation within neo-liberal governing regimes focusing on the reorganisation of civil society and the state from the late 1970s to the present primarily with examples from the UK. It suggests, contrary to much popular discussion, that there is a significant degree of continuity in the form of economic manage-ment followed before, during and after the recent financial crisis of 2008/09. Both in terms of ideology and practice, many governments have maintained and even deepened their commitment to depoliticised gov-erning principles. However it seems clear that attempts to depoliticise neo-liberal economic policy have not enabled state managers to avoid the emergence of crisis at the level of the state. Contrary to accounts which argue in simplistic fashion that `economic’ crisis produces `political’ crisis, this paper suggests that crisis is best understood as expressed simultaneously in both economic and political forms. Crisis at the level of the state precipitated in part by the entrenchment of depoliticised governing strategies is not simply the result of economic crisis but is an aspect of that crisis contributing to its depth and apparent insolubility. In this way the paper challenges some critiques of depoliticisation which have suggested (Hay 2014, 303 that the concept is in part both fatalistic and functionalist removing much of the political contingency of the moment of crisis itself.

  1. Locating ‘Contextual Bible Study’ within biblical liberation hermeneutics and intercultural biblical hermeneutics

    Directory of Open Access Journals (Sweden)

    Gerald O. West

    2014-10-01

    Full Text Available This article uses the occasion of the 70th anniversary of HTS Teologiese Studies/Theological Studies to reflect on a particular form of liberation hermeneutics that emerged in the 1980s in South Africa. ‘Contextual Bible Study’ is briefly defined, but its precise contours are explored by locating this form of liberation hermeneutics within liberation hermeneutics more generally and then intercultural biblical hermeneutics more specifically. The article sets up a dialogue amongst these practices, examining both their family resemblances and their distinctive features.

  2. Novels as Social Media : How Literature Helped Shape Notions of Sexual Liberation

    NARCIS (Netherlands)

    Andeweg, A.

    In the historiography of sexual liberation, the role of cultural artefacts like novels and films has either been taken for granted or not received much attention at all. This article discusses these cultural dimensions of sexual liberation,using the Netherlands as a case study, arguing that these

  3. Financial liberalization and financial fragility : the experiences of Chile and Indonesia compared

    NARCIS (Netherlands)

    Herpt, van Ingmar; Visser, Hans

    1994-01-01

    The far-reaching liberalization process introduced in Chile after the overthrow of the Allende regime first met with reasonable success, but in theearly 1980s a foreign-exchange crisis and a banking crisis appeared to mark the end of the experiment. Liberalization was resumed in 1985 and has notbeen

  4. The social practice of psychology and the social sciences in a liberal ...

    African Journals Online (AJOL)

    This paper explores the relevance of psychology and the social and human sciences in a changing South Africa. The new South Africa embraces a liberal democratic approach to government. The Reconstruction and Development Programme (RDP) is a policy document that articulates the goals of this liberal democratic ...

  5. Sermaye Hesabı Liberalizasyonu : Teorik Bir İnceleme = Capital Account Liberalization : a Theoretical Review

    Directory of Open Access Journals (Sweden)

    Turgut Türsoy

    2008-06-01

    Full Text Available This paper surveys the theoretical principals of the capital account liberalization and evaluate the literature on the effects of capital account openness on economic growth. Following the evaluation of literature, various measurements of capital account liberalization are discussed. After reviewing various measurements it can be seen that most countries have, to a great extend, opened their accounts to capital flows. But this paper shows that the empirical studies failed to provide evidence that there is a strong and prominent effect of capital account liberalization on economic growth. Despite the empirical studies, experimental studies analyzing the developments after liberalization in countries found that opening the capital account has an important effect on GDP.

  6. European Union gas market liberalization: a windfall effect for Russia?

    International Nuclear Information System (INIS)

    Riviere, Nicolas

    2013-01-01

    Natural gas has a growing importance in the European Union energy. However, because of the lack of resources in its territory, the EU is highly dependent on imports to meet its gas needs. In parallel, since 1998 the EU seeks the creation of a single and liberalized natural gas market. The aim of this thesis is to investigate whether the gas market liberalization can create a risk for importers' bargaining power and more widely to the gas security of supply of the EU. The first chapter provides an overview of the European gas market. It deals with the implementation of the process of gas market liberalization, the external dependency of the EU and the weakness of gas supply diversity. Using findings from the previous chapter, the second one proposes a model from the cooperative game theory to analyze the effects of the EU natural gas market liberalization on importers' bargaining power. It shows that the liberalization weakens importers' bargaining power vis-a-vis external suppliers, where Russia is the leader. It also shows that the implementation of a European gas purchasing agency offers a counter-power to the EU that balances bargaining power. The third chapter focuses on the development of LNG in the world and more specifically in the EU market. The development of LNG in Europe allows the entry of new operators on the upstream and, thus, increases competition among the EU's suppliers for the benefit of importers' bargaining power. The last chapter analyzes the impact of US shale gas development on the EU gas market. Thus, it shows that development is accompanied by an uncertainty about the future gas demand in the EU and by a reconsideration of the EU's long-term contracts. (author)

  7. In Defense of Japanese Liberal Education

    Science.gov (United States)

    Mori, Rie

    2016-01-01

    Liberal education has been a target of political discourse in many countries, and Japan is no exception. In Japanese higher education, there are three types of institutions: national public, local public, and private. In June 2015, Japan's minister of education, Hakubun Shimomura, called upon the country's national universities to take…

  8. Reprint of: Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease.

    Science.gov (United States)

    Mori, Trevor A

    2018-04-12

    Omega-6 (ω6) and omega-3 (ω3) fatty acids are two classes of dietary polyunsaturated fatty acids derived from linoleic acid (18:2ω6) and α-linolenic acid (18:3ω3), respectively. Enzymatic metabolism of linoleic and α-linolenic acids generates arachidonic acid (20:4ω6) and eicosapentaenoic acid (20:5ω3; EPA), respectively, both of which are substrates for enzymes that yield eicosanoids with multiple and varying physiological functions. Further elongation and desaturation of EPA yields the 22-carbon fatty acid docosahexaenoic acid (22:6ω3; DHA). The main dietary source of EPA and DHA for human consumption is fish, especially oily fish. There is considerable evidence that EPA and DHA are protective against cardiovascular disease (heart disease and stroke), particularly in individuals with pre-existing disease. ω3 Fatty acids benefit multiple risk factors including blood pressure, blood vessel function, heart function and blood lipids, and they have antithrombotic, anti-inflammatory and anti-oxidative actions. ω3 Fatty acids do not adversely interact with medications. Supplementation with ω3 fatty acids is recommended in individuals with elevated blood triglyceride levels and patients with coronary heart disease. A practical recommendation for the general population is to increase ω3 fatty acid intake by incorporating fish as part of a healthy diet that includes increased fruits and vegetables, and moderation of salt intake. Health authorities recommend the general population should consume at least two oily fish meals per week. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Neo-liberal economic practices and population health: a cross-national analysis, 1980-2004.

    Science.gov (United States)

    Tracy, Melissa; Kruk, Margaret E; Harper, Christine; Galea, Sandro

    2010-04-01

    Although there has been substantial debate and research concerning the economic impact of neo-liberal practices, there is a paucity of research about the potential relation between neo-liberal economic practices and population health. We assessed the extent to which neo-liberal policies and practices are associated with population health at the national level. We collected data on 119 countries between 1980 and 2004. We measured neo-liberalism using the Fraser Institute's Economic Freedom of the World (EFW) Index, which gives an overall score as well as a score for each of five different aspects of neo-liberal economic practices: (1) size of government, (2) legal structure and security of property rights, (3) access to sound money, (4) freedom to exchange with foreigners and (5) regulation of credit, labor and business. Our measure of population health was under-five mortality. We controlled for potential mediators (income distribution, social capital and openness of political institutions) and confounders (female literacy, total population, rural population, fertility, gross domestic product per capita and time period). In longitudinal multivariable analyses, we found that the EFW index did not have an effect on child mortality but that two of its components: improved security of property rights and access to sound money were associated with lower under-five mortality (p = 0.017 and p = 0.024, respectively). When stratifying the countries by level of income, less regulation of credit, labor and business was associated with lower under-five mortality in high-income countries (p = 0.001). None of the EFW components were significantly associated with under-five mortality in low-income countries. This analysis suggests that the concept of 'neo-liberalism' is not a monolithic entity in its relation to health and that some 'neo-liberal' policies are consistent with improved population health. Further work is needed to corroborate or refute these findings.

  10. Trade liberalization in the south east Europe: Effects and controversial issues

    Directory of Open Access Journals (Sweden)

    Pjerotić Ljiljana

    2008-01-01

    Full Text Available Included in the regional cooperation of SEE countries, trade liberalization is considered the most important factor of a sustainable economic growth which should contribute to the mutual trade among SEE countries, growth of the foreign direct investments, further production specialization and export structure change. Countries of the region have accepted liberalization as one of the conditions of the Stabilization and Association Process (SAP, hoping, each of them individually, that in that way they would improve proper position. Creating a free trade area will contribute to a further increase of intra-regional trade flows, but it shouldn't be expected that the relative importance of mutual exchange will prevail the importance which EU has for the SEE countries, except Moldova. Paper is divided into five sections. After the introduction, the trade liberalization process in the SEE region is explained in the second part (section 2. The third section analyses actual intra-regional trade flows and SEE countries trade relations with the EU (section 3. Some controversial issues raised in recent debates on trade liberalization in SEE are also discussed (section 4. The main conclusions are given at the end (section 5. .

  11. The BCLA Minor: Business, Communication, and Liberal Arts Minor at Towson University

    Science.gov (United States)

    Mahin, Linda

    2008-01-01

    In this article, the author describes a cross-disciplinary minor that combines elements of business, communication, and the liberal arts. The BCLA Minor enhances employment opportunities and cultural awareness for students with majors in the Colleges of Business and Economics, Fine Arts and Communication, and Liberal Arts by integrating the…

  12. Metabolomics of Dietary Fatty Acid Restriction in Patients with Phenylketonuria

    Science.gov (United States)

    Mütze, Ulrike; Beblo, Skadi; Kortz, Linda; Matthies, Claudia; Koletzko, Berthold; Bruegel, Mathias; Rohde, Carmen; Thiery, Joachim; Kiess, Wieland; Ceglarek, Uta

    2012-01-01

    Background Patients with phenylketonuria (PKU) have to follow a lifelong phenylalanine restricted diet. This type of diet markedly reduces the intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LC-PUFA). Long-chain saturated fatty acids are substrates of mitochondrial fatty acid oxidation for acetyl-CoA production. LC-PUFA are discussed to affect inflammatory and haemostaseological processes in health and disease. The influence of the long term PKU diet on fatty acid metabolism with a special focus on platelet eicosanoid metabolism has been investigated in the study presented here. Methodology/Principal Findings 12 children with PKU under good metabolic control and 8 healthy controls were included. Activated fatty acids (acylcarnitines C6–C18) in dried blood and the cholesterol metabolism in serum were analyzed by liquid chromatographic tandem mass spectrometry (LC-MS/MS). Fatty acid composition of plasma glycerophospholipids was determined by gas chromatography. LC-PUFA metabolites were analyzed in supernatants by LC-MS/MS before and after platelet activation and aggregation using a standardized protocol. Patients with PKU had significantly lower free carnitine and lower activated fatty acids in dried blood compared to controls. Phytosterols as marker of cholesterol (re-) absorption were not influenced by the dietary fatty acid restriction. Fatty acid composition in glycerophospholipids was comparable to that of healthy controls. However, patients with PKU showed significantly increased concentrations of y-linolenic acid (C18:3n-6) a precursor of arachidonic acid. In the PKU patients significantly higher platelet counts were observed. After activation with collagen platelet aggregation and thromboxane B2 and thromboxane B3 release did not differ from that of healthy controls. Conclusion/Significance Long-term dietary fatty acid restriction influenced the intermediates of mitochondrial beta-oxidation. No functional

  13. Metabolomics of dietary fatty acid restriction in patients with phenylketonuria.

    Directory of Open Access Journals (Sweden)

    Ulrike Mütze

    Full Text Available BACKGROUND: Patients with phenylketonuria (PKU have to follow a lifelong phenylalanine restricted diet. This type of diet markedly reduces the intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LC-PUFA. Long-chain saturated fatty acids are substrates of mitochondrial fatty acid oxidation for acetyl-CoA production. LC-PUFA are discussed to affect inflammatory and haemostaseological processes in health and disease. The influence of the long term PKU diet on fatty acid metabolism with a special focus on platelet eicosanoid metabolism has been investigated in the study presented here. METHODOLOGY/PRINCIPAL FINDINGS: 12 children with PKU under good metabolic control and 8 healthy controls were included. Activated fatty acids (acylcarnitines C6-C18 in dried blood and the cholesterol metabolism in serum were analyzed by liquid chromatographic tandem mass spectrometry (LC-MS/MS. Fatty acid composition of plasma glycerophospholipids was determined by gas chromatography. LC-PUFA metabolites were analyzed in supernatants by LC-MS/MS before and after platelet activation and aggregation using a standardized protocol. Patients with PKU had significantly lower free carnitine and lower activated fatty acids in dried blood compared to controls. Phytosterols as marker of cholesterol (re- absorption were not influenced by the dietary fatty acid restriction. Fatty acid composition in glycerophospholipids was comparable to that of healthy controls. However, patients with PKU showed significantly increased concentrations of y-linolenic acid (C18:3n-6 a precursor of arachidonic acid. In the PKU patients significantly higher platelet counts were observed. After activation with collagen platelet aggregation and thromboxane B(2 and thromboxane B(3 release did not differ from that of healthy controls. CONCLUSION/SIGNIFICANCE: Long-term dietary fatty acid restriction influenced the intermediates of mitochondrial beta

  14. Integration models: multicultural and liberal approaches confronted

    Science.gov (United States)

    Janicki, Wojciech

    2012-01-01

    European societies have been shaped by their Christian past, upsurge of international migration, democratic rule and liberal tradition rooted in religious tolerance. Boosting globalization processes impose new challenges on European societies, striving to protect their diversity. This struggle is especially clearly visible in case of minorities trying to resist melting into mainstream culture. European countries' legal systems and cultural policies respond to these efforts in many ways. Respecting identity politics-driven group rights seems to be the most common approach, resulting in creation of a multicultural society. However, the outcome of respecting group rights may be remarkably contradictory to both individual rights growing out from liberal tradition, and to reinforced concept of integration of immigrants into host societies. The hereby paper discusses identity politics upturn in the context of both individual rights and integration of European societies.

  15. The political economy of trade liberalization and environmental policy

    International Nuclear Information System (INIS)

    Fredriksson, P.G.

    1999-01-01

    A pressure group model where environmental and industry lobby groups offer political support in return for favorable pollution tax policies is used to explain and predict the equilibrium pollution tax in sectors protected by tariffs. The political economy effects of trade liberalization are investigated. The pollution tax is shown to decrease if the lobbying effort by the environmental lobby decreases more rapidly than by the industry lobby Ceteris paribus. The level of political conflict falls with trade liberalization. Pollution may increase because of a reduction of the pollution tax, and tax revenues may fall simultaneously as pollution increases

  16. The Learning Sciences and Liberal Education

    Science.gov (United States)

    Budwig, Nancy

    2013-01-01

    This article makes the case for a new framing of liberal education based on several decades of research emerging from the learning and developmental sciences. This work suggests that general knowledge stems from acquiring both the habits of mind and repertoires of practice that develop from participation in knowledge-building communities. Such…

  17. Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology

    Directory of Open Access Journals (Sweden)

    Haug Anna

    2011-01-01

    Full Text Available Abstract Eicosanoids are major players in the pathogenesis of several common diseases, with either overproduction or imbalance (e.g. between thromboxanes and prostacyclins often leading to worsening of disease symptoms. Both the total rate of eicosanoid production and the balance between eicosanoids with opposite effects are strongly dependent on dietary factors, such as the daily intakes of various eicosanoid precursor fatty acids, and also on the intakes of several antioxidant nutrients including selenium and sulphur amino acids. Even though the underlying biochemical mechanisms have been thoroughly studied for more than 30 years, neither the agricultural sector nor medical practitioners have shown much interest in making practical use of the abundant high-quality research data now available. In this article, we discuss some specific examples of the interactions between diet and drugs in the pathogenesis and therapy of various common diseases. We also discuss, using common pain conditions and cancer as specific examples, how a better integration between agricultural science, nutrition and pharmacology could lead to improved treatment for important diseases (with improved overall therapeutic effect at the same time as negative side effects and therapy costs can be strongly reduced. It is shown how an unnaturally high omega-6/omega-3 fatty acid concentration ratio in meat, offal and eggs (because the omega-6/omega-3 ratio of the animal diet is unnaturally high directly leads to exacerbation of pain conditions, cardiovascular disease and probably most cancers. It should be technologically easy and fairly inexpensive to produce poultry and pork meat with much more long-chain omega-3 fatty acids and less arachidonic acid than now, at the same time as they could also have a similar selenium concentration as is common in marine fish. The health economic benefits of such products for society as a whole must be expected vastly to outweigh the direct

  18. Economic Liberalism and the State: Dismantling the Myth of Naive Laissez-faire

    DEFF Research Database (Denmark)

    Stahl, Rune Møller

    2018-01-01

    -century liberalism is also characterised by an active use of state and legislative power. Through a historical study of two cases from 19th-century Britain, Poor Law reform and the Gold Standard, the paper will argue that state action played a central role even during the heyday of laissez-faire liberalism...

  19. A Holistic Approach to Estimating the Influence of Good Practices on Student Outcomes at Liberal Arts and non-Liberal Arts Institutions

    Directory of Open Access Journals (Sweden)

    Brian P. An

    2016-04-01

    Full Text Available Many higher education administrators and researchers have considered certain “good practices” of institutions as an instrumental way to improve student outcomes. Chickering and Gamson’s (1987 seven principles of good practice has been particularly salient in defining these practices. Often, prior studies only select some of the seven principles for their analysis. Even studies that consider several principles of good practice on student outcomes typically examine the net effect of each principle instead of assessing how these principles holistically influence student outcomes. Using structural equation modeling, we test a basic conceptual framework where we investigate the contribution of the seven principles on a global measure of good practices (GP, as well as the influence of GP on a multitude of student outcomes. We further test whether liberal arts colleges promote an institutional ethos of good practices as compared to non-liberal arts colleges. Overall, the majority (but not all of the principles affect GP. Moreover, we find partial evidence that liberal arts colleges foster an institutional ethos of good practices. Although a commitment to foster good practices may create a supportive environment that influences student outcomes, this commitment may lead to unintended consequences for those with little exposure to these good practices.

  20. Liberation of a pinned spiral wave by a rotating electric pulse

    Science.gov (United States)

    Chen, Jiang-Xing; Peng, Liang; Ma, Jun; Ying, He-Ping

    2014-08-01

    Spiral waves may be pinned to anatomical heterogeneities in the cardiac tissue, which leads to monomorphic ventricular tachycardia. Wave emission from heterogeneities (WEH) induced by electric pulses in one direction (EP) is a promising method for liberating such waves by using heterogeneities as internal virtual pacing sites. Here, based on the WEH effect, a new mechanism of liberation by means of a rotating electric pulse (REP) is proposed in a generic model of excitable media. Compared with the EP, the REP has the advantage of opening wider time window to liberate pinned spiral. The influences of rotating direction and frequency of the REP, and the radius of the obstacles on this new mechanism are studied. We believe this strategy may improve manipulations with pinned spiral waves in heart experiments.

  1. Vitamin B12 and eicosanoids in insects

    International Nuclear Information System (INIS)

    Wakayama, J.E.

    1985-01-01

    Vitamin B 12 was not detected in the house fly, Musca domestica, which apparently cannot interconvert propionate and succinate. In contrast, the termite readily interconverts succinate and methylmalonate, and contains high amounts of vitamin B 12 . The intestinal bacteria were the major source of vitamin B 12 in the termite, Coptotermes formosanus. The presence of arachidonic acid (20:4) and eicosatrienoic acid (20:3,n-6) at low levels in adult male and female house flies was demonstrated by chemical ionization-gas chromatography-mass spectrometry. After injection, over 80% of 20:4 was rapidly incorporated into the phospholipid (PL) fraction. Over 80% of the sequestered 20:4 was in the 2-position of PLs. The 20:4 was injected into the insect or was included in the diet prior to administration of [ 3 H] 20:4; large amounts of radioactivity were recovered in the triacylglycerol and free fatty acid fractions. Arachidonic acid (20:4) injected into house flies was rapidly converted to prostaglandins, and was also catabolized rapidly. Radiolabeled 20:4 injected into the hemolymph was incorporated into the reproductive tissues of male insects. About 2.1% of the total radioactivity from [ 3 H] 20:4 injected into males just prior to mating was transferred to females during mating

  2. Organizational Adaptation of Liberal Arts Colleges during the Great Recession of 2007

    Science.gov (United States)

    Hilbun, Ashlie Junot; Mamiseishvili, Ketevan

    2016-01-01

    The study we report here explored how private liberal arts colleges adapted to the Great Recession of 2007. We examined institutional changes at three private liberal arts colleges and their effects on the institutions' operations. For this multiple-case study we analyzed data from three colleges in the southeastern region of the United States;…

  3. Curriculum Revision in Practice: Designing a Liberal Arts Degree in Dance Professions

    Science.gov (United States)

    Risner, Doug

    2013-01-01

    Dance programs in higher education offering both professional degrees (BFA) and liberal arts degrees (BA, BS) often focus most of their energy, attention, and resources to ever-increasing BFA programs. At the same time, liberal arts programs in dance often provide the real bread and butter of program headcounts, credit hours generated, and degrees…

  4. Review: Martha Akawa, The Gender Politics of the Namibian Liberation Struggle (2014)

    OpenAIRE

    Henning Melber; Dag Hammarskjöld Foundation

    2014-01-01

    Review of the monograph:Martha Akawa, The Gender Politics of the Namibian Liberation Struggle, Basel: Basler Afrika Bibliographien, 2014, ISBN 978-3-905 758-26-9, 230 pp. Besprechung der Monographie:Martha Akawa, The Gender Politics of the Namibian Liberation Struggle, Basel: Basler Afrika Bibliographien, 2014, ISBN 978-3-905 758-26-9, 230 Seiten

  5. Slaves immersed in a liberal ideology.

    Science.gov (United States)

    Daly, Leslie Kim

    2012-01-01

    Paradigm debates have been featured in the nursing literature for over four decades. There are at least two opposing paradigms specific to nursing that have remained central in these debates. Advocates of the unitary perspective (or simultaneity paradigm) consider their theories to be more philosophically advanced and contemporary alternatives when compared to the older more traditional ideas characteristic of models they describe as originating from the totality paradigm. In the context of these debates, I focus on some theoretical positions embedded in the unitary perspective, noting their limitations with respect to integrating the individual and social mandates of nursing; nurses are responsible not only for individual health-related needs, but also for the health of the collective. I explore two hypotheses that may explain the powers of endurance of the unitary perspective. Paley, who outlines the origins of nurses' 'slave morality', inspires the first hypothesis. The second hypothesis speaks to the location of nursing knowledge development in the context of liberal ideology. In this work, I outline key conceptualizations of the unitary perspective in order to clearly illustrate the limitations of the unitary perspective for nurses' social mandate. Then, I explore how slave morality and liberal ideological assumptions might both work to sustain the unitary perspective. A paradigm for nursing must have utility in addressing both the health-related needs of individuals, and for addressing the health of the collective. To this end, I advance suggestions in three areas: first, to transform nurses' slave morality to more honest and noble aspirations; second, to examine liberal ideological premises; and third, to end paradigm debate by resituating elements of the unitary perspective to the level of mid-range theory, where it could be most effective for research and practice with specific populations. © 2011 Blackwell Publishing Ltd.

  6. Not All Education is Equally Liberal: The Effects of Science Education on Political Attitudes

    Directory of Open Access Journals (Sweden)

    Christine Ma-Kellams

    2014-07-01

    Full Text Available Education stands as a potent predictor of political attitudes; however, the underlying mechanisms and moderators of this relationship are not well-understood. We hypothesize that the liberalizing effect of education is moderated by discipline, and that the scientific ethos that serves to guide empirical inquiries facilitates the development of more liberal political attitudes via concerns about fairness and equality. As predicted, being educated in a science-related discipline, as opposed to a non-science discipline, was associated with greater political liberalism; importantly, this effect could not be accounted for by self-selection (Study 1. Furthermore, concerns about fairness and equality, as captured by an individual’s social dominance orientation, mediated the relationship between studying science and political liberalism (Study 2. Study 3 replicated these findings and attest to their generalizability. Study 4 directly assessed the underlying mechanism, endorsement of the scientific ethos, and replicated the mediational model; those who endorsed the scientific ethos more strongly reported more liberal political attitudes, and this was mediated by their lower social dominance orientation.

  7. Does trade liberalization increase global pollution?

    International Nuclear Information System (INIS)

    Beladi, Hamid; Oladi, Reza

    2011-01-01

    In this paper we consider a simple duopoly market in which a home firm and a foreign firm use labor to produce an identical product and supply it to the home market. Firms emit pollution as a by-product of production. We show conditions under which international trade liberalization decreases (increases) the global pollution. (author)

  8. Development Implications of Liberalization of Trade in Services ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Development Implications of Liberalization of Trade in Services ... disseminated by the United Nations Conference on Trade and Development (UNCTAD). ... The Honourable Chrystia Freeland, Minister of International Trade, announced a ...

  9. General Equilibrium Analysis of Electricity Market Liberalization in Singapore: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Fenglong XIAO

    2011-12-01

    Full Text Available The liberalization in electricity market in Singapore has being undertaken for more than 15 years. This paper evaluates the influence of competition policies by computable general equilibrium (CGE model. Instead of the direct measurement of the impact of competition policy, the benefit of liberalization is reflected by the simulation of a hypothetical regulatory condition. Comparing to the regulatory scenario, simulation result implies the current liberalization raises GDP and exchange rate significantly, but also leaves the tradeoff between higher national income and lower consumer welfare to government. If such choice of economic policy is necessary for political demand, a formal legal framework is required to enforce the restoration of the economy from regulatory restrictions.

  10. Blending the liberal arts and nursing: Creating a portrait for the 21st century.

    Science.gov (United States)

    Kooken, Wendy Carter; Kerr, Noël

    The liberal arts and sciences serve as a core part of the educational discipline in nursing curriculum and are believed to undergird abilities for critical-thinking, creativity, and holistic care (Hermann, 2004; McKie, 2012). Over time, science has taken on a more central role in nursing education, despite the acknowledged importance and contributions of liberal arts. The humanities are an essential part of liberal arts education and generally include disciplines such as history, literature, religion, philosophy, architecture, or fine arts (e.g., music, painting, sculpture, drama, or film) (Hermann, 2004). Nursing students identify that liberal arts improve their skills to communicate, think globally, navigate diversity, make decisions, and improve their human selves (McKie, 2012), therefore the purposeful inclusion of liberal arts and humanities into nursing pedagogy should be assured. Schools of nursing seated within liberal arts universities are in a position to take advantage of campus environments that seek to improve student knowledge, skills, abilities, and values (Scott, 2014). When caring for patients with complex medical, psychosocial, spiritual, and economic concerns, the ability to differentiate between what is true among a myriad of competing issues, and to identify solutions to these problems, are critical skills (Scott, 2014). This manuscript describes one type of focused effort by school of nursing (SON) faculty to integrate the humanities on a small, liberal arts campus into the nursing curriculum. The desire to do this led to a large, interdisciplinary project intended to enhance campus, community, faculty, and student opportunities to understand and ponder the complexities involved in caring for patients with Alzheimer's disease (AD). Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Transboundary Pollution, Trade Liberalization and Environmental Taxes

    NARCIS (Netherlands)

    Baksi, S.; Ray Chaudhuri, A.

    2008-01-01

    In a bilateral trade framework, we examine the impact of tariff reduction on the optimal pollution tax and social welfare when pollution is transboundary. Strategic considerations lead countries to distort their pollution tax in the non-cooperative equilibrium. Trade liberalization changes the

  12. Arachidonic acid metabolites in normal and autoimmune mice do not influence lymphocyte-high endothelial venule interactions.

    Science.gov (United States)

    Manolios, N; Bakiera, B; Geczy, C L; Schrieber, L

    1991-02-01

    In peripheral lymphoid organs the number of lymphocytes and the proportion of functional lymphocyte subsets are regulated by multiple factors including the control of lymphocyte migration by selective lymphocyte-high endothelial venule (HEV) interactions. In this study, prostaglandin E2 (PGE2) levels from normal and autoimmune mouse lymph node cells were measured. The contribution of eicosanoids to lymphocyte-HEV interactions in normal (CBA/T6) and autoimmune (MRL/n) mice was examined. There was no association between PGE2 production in normal or autoimmune mice and the age of onset of disease activity in the latter strains. Arachidonic acid metabolites, in particular PGE2 and leukotriene B4 (LTB4), did not have any effects on lymphocyte-HEV binding. Likewise, lymphocytes treated in vivo and/or in vitro with arachidonic acid metabolite inhibitors (acetyl salicylic acid, indomethacin, BW755C) did not alter lymphocyte-HEV binding interactions in both normal and autoimmune mice. No clinical significance could be attributed to lymph node PGE2 production and the age of onset of autoimmune disease. In summary, these findings cast doubt on the role of arachidonic acid metabolites in lymphocyte-HEV binding interactions.

  13. Comprehensive primary health care under neo-liberalism in Australia.

    Science.gov (United States)

    Baum, Fran; Freeman, Toby; Sanders, David; Labonté, Ronald; Lawless, Angela; Javanparast, Sara

    2016-11-01

    This paper applies a critical analysis of the impact of neo-liberal driven management reform to examine changes in Australian primary health care (PHC) services over five years. The implementation of comprehensive approaches to primary health care (PHC) in seven services: five state-managed and two non-government organisations (NGOs) was tracked from 2009 to 2014. Two questions are addressed: 1) How did the ability of Australian PHC services to implement comprehensive PHC change over the period 2009-2014? 2) To what extent is the ability of the PHC services to implement comprehensive PHC shaped by neo-liberal health sector reform processes? The study reports on detailed tracking and observations of the changes and in-depth interviews with 63 health service managers and practitioners, and regional and central health executives. The documented changes were: in the state-managed services (although not the NGOs) less comprehensive service coverage and more focus on clinical services and integration with hospitals and much less development activity including community development, advocacy, intersectoral collaboration and attention to the social determinants. These changes were found to be associated with practices typical of neo-liberal health sector reform: considerable uncertainty, more directive managerial control, budget reductions and competitive tendering and an emphasis on outputs rather than health outcomes. We conclude that a focus on clinical service provision, while highly compatible with neo-liberal reforms, will not on its own produce the shifts in population disease patterns that would be required to reduce demand for health services and promote health. Comprehensive PHC is much better suited to that task. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  14. Manumisión, ritualidad y fiesta liberal en la provincia de Cartagena durante el siglo XIX.

    Directory of Open Access Journals (Sweden)

    Dolcey Romero Jaramillo.

    2005-01-01

    Full Text Available Manumission, rituality, and liberal festivities in the province of Cartagena de Indias in the 19th CenturyThis article describes the rituals that accompanied acts of manumission in the province of Cartagena during the nineteenth century and the way in which liberals took advantage of these events to create propaganda for their own utopian liberalism. They thus tried to present themselves both as modernists and lovers of liberty. The acts of manumission, which were almost anonymous until 1821, contrast with the majesty and splendor that characterized such acts after the triumph of liberalism in 1849. Notwithstanding the fact that many elements of liberal symbolism were propagated through said acts, they were extremely precarious with respect to the question of granting freedom to the descendents of African slaves.

  15. Trade Liberalization and Pollution Havens

    OpenAIRE

    Josh Ederington; Arik Levinson; Jenny Minier

    2004-01-01

    U.S. Presidential Executive Order 13141 commits the United States to a careful assessment and consideration of the environmental impacts of trade agreements.' The most direct mechanism through which trade liberalization would affect environmental quality in the U.S. is through changes in the composition of industries. Freer trade means greater specialization, increasing the concentration of polluting industries in some countries and decreasing it in others. Indeed, in this paper we predict a ...

  16. Trade Liberalization and Pollution Havens

    OpenAIRE

    Josh Ederington, Arik Levinson, and Jenny Minier

    2004-01-01

    U.S. Presidential Executive Order 13141 commits the United States to a "careful assessment and consideration of the environmental impacts of trade agreements." The most direct mechanism through which trade liberalization would affect environmental quality in the U.S. is through changes in the composition of industries. Freer trade means greater specialization, increasing the concentration of polluting industries in some countries and decreasing it in others. Indeed, in this paper we predict a...

  17. Child Labor and Trade Liberalization in Indonesia

    NARCIS (Netherlands)

    K.K. Krisztina (Kis-Katos); R.A. Sparrow (Robert)

    2009-01-01

    textabstractWe examine the effects of trade liberalization on child work in Indonesia. Our estimation strategy identifies geographical differences in the effects of trade policy through district level exposure to reduction in import tariff barriers. We use a balanced panel of 261 districts, based

  18. Transboundary Pollution, Trade Liberalization, and Environmental Taxes

    NARCIS (Netherlands)

    Baksi, S.; Ray Chaudhuri, A.

    2008-01-01

    In a bilateral trade framework, we examine the impact of tari¤ reduction on the op- timal pollution tax and social welfare when pollution is transboundary. Strategic considerations lead countries to distort their pollution tax in the non-cooperative equilibrium. Trade liberalization changes the

  19. Liberating Leadership Capacity: Pathways to Educational Wisdom

    Science.gov (United States)

    Lambert, Linda; Zimmerman, Diane P.; Gardner, Mary E.

    2016-01-01

    During the past quarter century, conceptions of leadership have evolved in concert with breakthrough discoveries in science and generative learning. "Liberating Leadership Capacity" captures these new ideas through the integration of the authors' earlier works in constructivist leadership and leadership capacity. What emerges is a…

  20. Africa's wars of liberation : some historiographical reflections

    NARCIS (Netherlands)

    Ellis, S.; Konings, P.; Binsbergen, van W.; Hesseling, G.

    2000-01-01

    This chapter examines the ways in which scholars have considered African wars of liberation. Firstly, the author considers some of the general assumptions which have been commonly applied to African history since the middle of the twentieth century when academic historical writing on Africa began,

  1. Tandem Mass Spectrometry and Ion Mobility Reveals Structural Insight into Eicosanoid Product Ion Formation.

    Science.gov (United States)

    Di Giovanni, James P; Barkley, Robert M; Jones, David N M; Hankin, Joseph A; Murphy, Robert C

    2018-04-23

    Ion mobility measurements of product ions were used to characterize the collisional cross section (CCS) of various complex lipid [M-H] - ions using traveling wave ion mobility mass spectrometry (TWIMS). TWIMS analysis of various product ions derived after collisional activation of mono- and dihydroxy arachidonate metabolites was found to be more complex than the analysis of intact molecular ions and provided some insight into molecular mechanisms involved in product ion formation. The CCS observed for the molecular ion [M-H] - and certain product ions were consistent with a folded ion structure, the latter predicted by the proposed mechanisms of product ion formation. Unexpectedly, product ions from [M-H-H 2 O-CO 2 ] - and [M-H-H 2 O] - displayed complex ion mobility profiles suggesting multiple mechanisms of ion formation. The [M-H-H 2 O] - ion from LTB 4 was studied in more detail using both nitrogen and helium as the drift gas in the ion mobility cell. One population of [M-H-H 2 O] - product ions from LTB 4 was consistent with formation of covalent ring structures, while the ions displaying a higher CCS were consistent with a more open-chain structure. Using molecular dynamics and theoretical CCS calculations, energy minimized structures of those product ions with the open-chain structures were found to have a higher CCS than a folded molecular ion structure. The measurement of product ion mobility can be an additional and unique signature of eicosanoids measured by LC-MS/MS techniques. Graphical Abstract ᅟ.

  2. Tandem Mass Spectrometry and Ion Mobility Reveals Structural Insight into Eicosanoid Product Ion Formation

    Science.gov (United States)

    Di Giovanni, James P.; Barkley, Robert M.; Jones, David N. M.; Hankin, Joseph A.; Murphy, Robert C.

    2018-04-01

    Ion mobility measurements of product ions were used to characterize the collisional cross section (CCS) of various complex lipid [M-H]- ions using traveling wave ion mobility mass spectrometry (TWIMS). TWIMS analysis of various product ions derived after collisional activation of mono- and dihydroxy arachidonate metabolites was found to be more complex than the analysis of intact molecular ions and provided some insight into molecular mechanisms involved in product ion formation. The CCS observed for the molecular ion [M-H]- and certain product ions were consistent with a folded ion structure, the latter predicted by the proposed mechanisms of product ion formation. Unexpectedly, product ions from [M-H-H2O-CO2]- and [M-H-H2O]- displayed complex ion mobility profiles suggesting multiple mechanisms of ion formation. The [M-H-H2O]- ion from LTB4 was studied in more detail using both nitrogen and helium as the drift gas in the ion mobility cell. One population of [M-H-H2O]- product ions from LTB4 was consistent with formation of covalent ring structures, while the ions displaying a higher CCS were consistent with a more open-chain structure. Using molecular dynamics and theoretical CCS calculations, energy minimized structures of those product ions with the open-chain structures were found to have a higher CCS than a folded molecular ion structure. The measurement of product ion mobility can be an additional and unique signature of eicosanoids measured by LC-MS/MS techniques. [Figure not available: see fulltext.

  3. Review: John S. Saul, Liberation Lite: The Roots of Recolonization in Southern Africa (2011 Buchbesprechung: John S. Saul, Liberation Lite: The Roots of Recolonization in Southern Africa (2011

    Directory of Open Access Journals (Sweden)

    Henning Melber

    2012-01-01

    Full Text Available Review of the monograph: John S. Saul, Liberation Lite: The Roots of Recolonization in Southern Africa, Trenton, N.J.: Africa World Press, 2011, ISBN 978-1-59221-835-6, 133 pagesBesprechung der Monographie: John S. Saul, Liberation Lite: The Roots of Recolonization in Southern Africa, Trenton, N.J.: Africa World Press, 2011, ISBN 978-1-59221-835-6, 133 Seiten

  4. On the fractionation of natural radioactivity in the production of phosphoric acid by the wet acid method

    International Nuclear Information System (INIS)

    Bolivar, J.P.; Garcia-Tenorio, R.; Garcia-Leon, M.

    1996-01-01

    The fractionation of different natural radionuclides (U-isotopes, 226 Ra and 210 Po) in the process used for the production of phosphoric acid in some factories located in the south-west of Spain is analyzed. As a consequence, different ways of natural radionuclide liberation to the environment can be evaluated due to these industrial activities. (author). 9 refs., 2 figs., 3 tabs

  5. Radiation damage of proteins in the solid state: changes of amino acid composition in catalase

    International Nuclear Information System (INIS)

    Baumeister, W.; Hahn, M.; Seredynski, J.; Herbertz, L.M.

    1976-01-01

    Catalase has been irradiated with 100 keV electrons under conditions simulating the hazards of electron microscopic imaging. Amino acid analysis reveals a definite pattern of amino acid destruction which is well correlated with the particular chemical structures of amino acid side chains. This pattern appears to be distinctly different from the sensitivity pattern for monoamino acid systems which is ascribed to intramolecular energy transfer and selective attack of liberated radicals

  6. Marea guvernare liberală: independenţa României şi proclamarea Regatului (The Great Liberal Government: the Romanian Independence and the Monarchy

    Directory of Open Access Journals (Sweden)

    Dan CARBARĂU

    2015-06-01

    Full Text Available The study below is putting together, in a historical view, important events for the Romanian history. Brief, the research is related to the period between 1876 and 1888, also called by historians “The Great liberal government”, when the national ideals were made real. The study tells about the State Independence (1877, the Constitution revision (1879 and finally, the transition to monarchy (1881. By putting together, the study shares how the National Liberal Party and its past leaders were able to put above the party interests and national interests, leaving the individualism behind.

  7. Are households better off in liberalized electricity markets

    DEFF Research Database (Denmark)

    Olsen, Ole Jess; Johnsen, Tor Arnt; Pakkanen, Merja

    wholesale market. Norway was first (1991), then came Finland and Sweden (1996) and Denmark was last (2000). Together with the UK the Nordic countries are now considered the avantgarde with respect to implementation of the European electricity market directives. The purpose of liberalization is to increase...... utilities mostly acted under very little surveillance and the authorities only intervened in specific cases of abuse. The separation of operational and regulatory functions was far from clear-cut - state and municipal agencies often had both functions. Today much more detailed principles of regulations...... administrated by independent regulatory agencies have been developed. The purpose of this paper is to analyze the situation for Nordic household consumers after liberalization of the electricity supply industry. A number of new regulatory principles have been introduced and some of them with particular regard...

  8. Liberalization of Russian gas exports: benefits and challenges

    Directory of Open Access Journals (Sweden)

    Yakunina Alla

    2017-01-01

    Full Text Available Russian gas export liberalization has been discussed throughout the post-Soviet period. Recently, the number of Gazprom’s export monopoly advocates has been diminishing as a result of dramatic changes in both European and Russian gas markets, which are: increasing international trade in liquefied natural gas; the EU movement from long-term contracts to the commodity markets and hub pricing; substantially increased share of the non-Gazprom gas suppliers at the Russian domestic market. Although there is a potential risk of price decrease in the EU gas market in the case of the Gazprom export monopoly abolition, the benefits of the Russian gas export liberalization would be greater than losses. The gas resource base and the cost of pipeline gas production would allow Russia to improve its positions in the world market.

  9. Risk and investment management in liberalized electricity markets

    DEFF Research Database (Denmark)

    Lemming, Jacob Kjærgaard

    2005-01-01

    markets affects the nancial risk related to different decision problems within the areas of risk management and investments in liberalized electricity markets. Focus is on applied microeconomics and analyzes of the interplay between market design parameters and the technical characteristics...... of the electricity system. Theory, literature and introduction to speci c problem areas related to risk management and investments is provided in two separate introductory chapters. Contributions to research within specific problems areas is then subsequently provided by five research papers. The two topics...... are relatively broad, however the two chapters and ve papers all share analyzes of nancial risk in liberalized electricity markets as a common underlying theme. The risk management part of the thesis focusses on modelling and measurement of financial risk in electricity markets. Key topics are electricity price...

  10. The Double Dividend Hypothesis and Trade Liberalization

    NARCIS (Netherlands)

    Sen, P.; Smulders, J.A.

    2000-01-01

    This paper studies how simultaneously liberalizing trade and tightening environmental policy affect welfare in a second-best world. We consider a three-good two-factor small open economy. We allow for non-tradables and for market power in the export market. The government is constrained to balance

  11. In Support of the Liberal Arts College.

    Science.gov (United States)

    Long, Dorothy S.

    1980-01-01

    The liberal arts college is in jeopardy. In trying to compete with the university, it has permitted external factors to disrupt its internal integrity. A brief examination of the elective system, expanded departmentalization, and the changing role of the professor are examples of such compromises. (Author/BEF)

  12. Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment.

    Directory of Open Access Journals (Sweden)

    Samantha P Tull

    2009-08-01

    Full Text Available Inflammation is a physiological response to tissue trauma or infection, but leukocytes, which are the effector cells of the inflammatory process, have powerful tissue remodelling capabilities. Thus, to ensure their precise localisation, passage of leukocytes from the blood into inflamed tissue is tightly regulated. Recruitment of blood borne neutrophils to the tissue stroma occurs during early inflammation. In this process, peptide agonists of the chemokine family are assumed to provide a chemotactic stimulus capable of supporting the migration of neutrophils across vascular endothelial cells, through the basement membrane of the vessel wall, and out into the tissue stroma. Here, we show that, although an initial chemokine stimulus is essential for the recruitment of flowing neutrophils by endothelial cells stimulated with the inflammatory cytokine tumour necrosis factor-alpha, transit of the endothelial monolayer is regulated by an additional and downstream stimulus. This signal is supplied by the metabolism of the omega-6-polyunsaturated fatty acid (n-6-PUFA, arachidonic acid, into the eicosanoid prostaglandin-D(2 (PGD(2 by cyclooxygenase (COX enzymes. This new step in the neutrophil recruitment process was revealed when the dietary n-3-PUFA, eicosapentaenoic acid (EPA, was utilised as an alternative substrate for COX enzymes, leading to the generation of PGD(3. This alternative series eicosanoid inhibited the migration of neutrophils across endothelial cells by antagonising the PGD(2 receptor. Here, we describe a new step in the neutrophil recruitment process that relies upon a lipid-mediated signal to regulate the migration of neutrophils across endothelial cells. PGD(2 signalling is subordinate to the chemokine-mediated activation of neutrophils, but without the sequential delivery of this signal, neutrophils fail to penetrate the endothelial cell monolayer. Importantly, the ability of the dietary n-3-PUFA, EPA, to inhibit this process not

  13. Liberalization of electricity markets and energy security

    International Nuclear Information System (INIS)

    Yajima, Masayuki

    2004-01-01

    Liberalization of electricity markets begun in England in 1990 and became the trends of the times. Its effects on the energy security and atomic power generation are discussed. On the effects on energy security, change of construction of fuel of power generation, decrease of fuel feed by high efficiency of power generation, decrease of fuel stock by pressure of cost-cutting, increase of import rate of electricity, increase of power consumption with decrease of power cost, flexibility of supply contract, diversification of service, international cooperation on energy security and mutual dependence relation by international investment are discussed. On the effects of liberalization on the electricity markets, characteristics of nuclear power generation, risk of investment, effects of introduction of competition on development of the existing and new nuclear power generation, relation between development of nuclear power generation and market failure and what the government should do for development of nuclear power generation are discussed. (S.Y.)

  14. "Humanitas", Metaphysics and Modern Liberal Arts

    Science.gov (United States)

    Tubbs, Nigel

    2014-01-01

    There is a new myth of the heterogeneous that is reducing the concept of humanity to a sinful enlightenment. In this article I investigate the contribution that a renewed understanding of liberal arts education might offer for the idea of a humanist education and for the concept of humanity; and this at a time when not only the concept of humanity…

  15. Trade Liberalization and Organizational Change

    OpenAIRE

    Paola Conconi; Patrick Legros; Andrew F. Newman

    2008-01-01

    We embed a simple incomplete-contracts model of organization design in a standard two-country perfectly-competitive trade model to examine how the liberalization of product and factor markets affects the ownership structure of firms. In our model, managers decide whether or not to integrate their firms, trading off the pecuniary benefits of coordinating production decisions with the private benefits of operating in their preferred ways. The price of output is a crucial determinant of this cho...

  16. Trade liberalization and gender inequality

    OpenAIRE

    Pieters, Janneke

    2015-01-01

    Women consistently work less in the labor market and earn lower wages than men. While economic empowerment of women is an important objective in itself, women's economic activity also matters as a condition for sustained economic growth. The political debate on the labor market impacts of international trade typically differentiates workers by their educational attainment or skills. Gender is a further dimension in which the impacts of trade liberalization can differ. In a globalizing world i...

  17. Issues and prospects of digitizing liberation movements' archives ...

    African Journals Online (AJOL)

    User

    promote access to information held in the liberation movements' ... availed for user consumption is one challenge that has emerged. .... the management of historical records and archives .... the system, such as the operating system hardware ...

  18. Security of supply in the liberalized energy market

    International Nuclear Information System (INIS)

    Boffa, Federico

    2007-01-01

    The incentive schemes in the liberalized energy markets do not ensure short-term security of supply. The paper analyzes the regulatory measures suitable to tackle the issue, and evaluates their effects on market power [it

  19. Liberation Space” and Times of Resistance in Visual Records

    Directory of Open Access Journals (Sweden)

    Jeong Sim Yang

    2014-08-01

    Full Text Available This paper attempts to discuss social aspects of the “liberation space” or the history of three years after the Korean liberation from the Japanese colonial rule, through audiovisual records of the time. The object of analyses will be audiovisual resources, specifically news films and documentary films, which are rooted in facts. The use of not only written documents but also photographs, posters, and other historical resources is increasing in studying Korean history. This paper will reconstruct the space of liberation based on vivid audiovisual records of the time. In particular, this paper focuses on the points in films that deviate from the motives and intentions of the United States Army Military Government in Korea (USAMGIK, which was the principal agent that produced and screened the films examined in this paper. This study attempts to capture and ruminate on the significance of the moments of Korean peoples’ struggle for the right to live and their political protests to stop the division of the Korean Peninsula under the oppression of USAMGIK.

  20. Liberalism in the Islamic World and its influence in the Malay Archipelago: Model in Indonesia

    Directory of Open Access Journals (Sweden)

    Abbas Mansur Tamam

    2014-06-01

    Full Text Available Liberalism means here Orientalist attempt to attract even Islam conformity with the principles of Western liberalism in form and substance. Hence Zhardha in the Islamic world have to do Orientalism, which under his leadership became the U.S. currently wants Islam that corresponds to the values of modernity and secularism and Western liberalism. And this phenomenon coincides appearance in the Islamic world with its appearance Malay archipelago and Indonesia to face particular Alholanda since colonial days, and then taking this trend develops even have an influence on contemporary history in these islands. So this includes talking on two things: Orientalist role for the emergence of liberalism in the Islamic world, and its influence in the Malay islands.

  1. Legitimacy and consensus in Rawls' political liberalism

    NARCIS (Netherlands)

    Rossi, E.

    2014-01-01

    In this paper I analyze the theory of legitimacy at the core of John Rawls’ political liberalism. Rawls argues that a political system is well grounded when it is stable. This notion of stability embodies both pragmatic and moral elements, each of which constitutes a key desideratum of Rawlsian

  2. Exploring thought leadership, thought liberation and critical ...

    African Journals Online (AJOL)

    It is argued that any discussion of Africa's social and economic development has to take into account the three critical issues that remain pressing constraints for the further advancement of well-being in Africa: thought leadership, thought liberation and critical consciousness. These three 'ingredients' should anchor aspects ...

  3. Friendship in the Life and Work of Mary Wollstonecraft: The Making of a Liberal Feminist Tradition

    DEFF Research Database (Denmark)

    Pedersen, Joyce Senders

    2008-01-01

    Mary Wollstonecrafts venskaber placeres indenfor en liberal fortolkningstradition . Udgivelsesdato: Spring 2008......Mary Wollstonecrafts venskaber placeres indenfor en liberal fortolkningstradition . Udgivelsesdato: Spring 2008...

  4. Dictatorship, liberalism and the Pareto rule: Possible and impossible

    Directory of Open Access Journals (Sweden)

    Boričić Branislav

    2009-01-01

    Full Text Available The current economic crisis has shaken belief in the capacity of neoliberal 'free market' policies. Numerous supports of state intervention have arisen, and the interest for social choice theory has revived. In this paper we consider three standard properties for aggregating individual into social preferences: dictatorship, liberalism and the Pareto rule, and their formal negations. The context of the pure first-order classical logic makes it possible to show how some combinations of the above mentioned conditions, under the hypothesis of unrestricted domain, form simple and reasonable examples of possible or impossible social choice systems. Due to their simplicity, these examples, including the famous 'liberal paradox', could have a particular didactic value.

  5. The EU's major electricity and gas utilities since market liberalization

    International Nuclear Information System (INIS)

    Schuelke, Christian

    2011-06-01

    A major change has taken place in the company structure of the European electricity and gas markets. Twenty years ago, national or regional monopolies dominated the markets and there was strictly no competition between utilities. But since the liberalization of EU energy markets began in the 1990's, companies like E.ON, GDF Suez, EDF, Enel, and RWE have become European giants with activities in a large number of Member States. The advocates of market liberalization did not expect, or even intend, the emergence of a small number of large utilities that control an increasing part of the EU market. Some observers already claim that liberalization has led to an oligopoly with detrimental consequences for competition. Based on extensive background research, this book presents a fact-based analysis of the changes in the European utility sector since the 1990's. Case studies of the seven largest utilities illustrate how companies adapted their strategies to the changing market environment. The author underlines diverging choices and common trends like geographic expansion into new markets via mergers and acquisitions or diversification of business activities with the aim of using synergies between electricity and gas. Contents: Executive Summary. Introduction. Seven Case Studies of Changing Strategies of Major European Energy Utilities since Market Liberalization (E.ON, GDF Suez, EDF, Enel, RWE, Iberdrola, Vattenfall, Other European Utilities). Overview of Major National and Regional Electricity and Gas Market in the EU (Germany, France, United Kingdom, Italy, Spain, Nordic, Belgium and the Netherlands, Central and Eastern Europe). Conclusions. Annex. Bibliography

  6. Jasmonic acid/methyl jasmonate accumulate in wounded soybean hypocotyls and modulate wound gene expression.

    Science.gov (United States)

    Creelman, R A; Tierney, M L; Mullet, J E

    1992-06-01

    Jasmonic acid (JA) and its methyl ester, methyl jasmonate (MeJA), are plant lipid derivatives that resemble mammalian eicosanoids in structure and biosynthesis. These compounds are proposed to play a role in plant wound and pathogen responses. Here we report the quantitative determination of JA/MeJA in planta by a procedure based on the use of [13C,2H3]MeJA as an internal standard. Wounded soybean (Glycine max [L] Merr. cv. Williams) stems rapidly accumulated MeJA and JA. Addition of MeJA to soybean suspension cultures also increased mRNA levels for three wound-responsive genes (chalcone synthase, vegetative storage protein, and proline-rich cell wall protein) suggesting a role for MeJA/JA in the mediation of several changes in gene expression associated with the plants' response to wounding.

  7. Promoting Liberal Arts Thinking through Online Discussion: A Practical Application and its Theoretical Basis

    Directory of Open Access Journals (Sweden)

    Dr. Dave S. Knowlton

    2002-07-01

    Full Text Available Addressing Carsten and Worsfold's (2000 assertion that online learning eliminates the possibility for "liberal learning," the author of this paper describes the context and guidelines for an online discussion assignment that he used as a faculty member at a liberal arts college. The purpose of this assignment was to help students engage in personal development by examining the ways course content manifested itself in their own lives. After describing the assignment guidelines, the author connects the assignment to numerous theories that are often associated with "liberal arts" learning. This theoretical explication includes connections to the need for a synthesis between the personal and professional selves, notions of constructing knowledge, and online discussion's placement within the writing process. The implication of this article is that the instructional strategies embedded in an online discussion, not the online environment itself, sustains a liberal education.

  8. Slavic issue and Russian nationalism in liberal journalism in 1860s

    Directory of Open Access Journals (Sweden)

    Екатерина Юрьевна Федорова

    2013-12-01

    Full Text Available The article is devoted to the problems of the nationalism perception in the liberal journalism in the 1860s. The author reveals the political and ideological factors which prompted liberalism theorists K.D. Kavelin, B.N. Chicherin, A.D. Gradovsky to consider national issues. There are analyzed the common and particular features in the works of publicists of public school. Special attention is paid to their attitude to the Slavic idea, the Polish issue and the Russian nationalism.

  9. Liberal or Conservative? Genetic Rhetoric, Disability, and Human Species Modification

    Directory of Open Access Journals (Sweden)

    Christopher F. Goodey

    2016-11-01

    Full Text Available A certain political rhetoric is implicit and sometimes explicit in the advocacy of human genetic modification (indicating here both the enhancement and the prevention of disability. The main claim is that it belongs to a liberal tradition. From a perspective supplied by the history and philosophy of science rather than by ethics, the content of that claim is examined to see if such a self-description is justified. The techniques are analyzed by which apparently liberal arguments get to be presented as “reasonable” in a juridical sense that draws on theories of law and rhetoric.

  10. Liberalism as a Cultural Phenomenon of Russian Provincial Life of the Late Nineteenth – Early Twentieth Centuries (according to Voronezh province

    Directory of Open Access Journals (Sweden)

    Evgeniy V. Dvoretskiy

    2016-12-01

    Full Text Available The authors of the presented research considers liberalism as a cultural phenomenon, closely watches the liberalism as an impact factor to cultural life in rural areas (esp. in Voronezh province in the end of XIX up to XX cent.. Besides, the authors make a try of consideration of liberalism in the context of European innovations blending conception. According to this idea the traditional society was transformed by means of technical, political, social and cultural innovation expansion from their source, which is in the Western Europe. Different sources served as a basis for the research, their analysis gives the reason to shape out the place and the role of Russian liberalism in the end of XIX up to the beginning of XX cent. in the formation of innovative elements of urban culture, and to specify the process of the liberal ideas expansion in the provincial cultural life sphere, and to characterize the bearer and translators of liberal ideas (local liberal figures, participants of the local liberal parties, liberal intellectuals. As a result, the existence of the basic liberal values reflections (freedom and preciousness of a personal identity, individualism and so on was stated, that shows the Russian liberalism as the ideal, political and cultural phenomenon. This, finally, states the great degree of the reception of the liberal ideas by the Russian society in the beginning of the XXth, and gives the opportunity to observe the liberal reflections as a process of civil society’s formation evidence in Russia by the beginning of the XXth cent.

  11. Ethnic and gender earning gaps in a liberalized economy: The case of Israel.

    Science.gov (United States)

    Bental, Benjamin; Kraus, Vered; Yonay, Yuval

    2017-03-01

    During the 1990s and the 2000s Israel, a country ethnically divided into a dominant Jewish majority and a disadvantaged mostly Muslim Palestinian minority, underwent a transition from a heavily regulated to a neo-liberal economy. This paper makes use of the Israeli case to shed light on the effect of liberalization on earning gaps in the public and private sectors across dominant and disadvantaged population groups. The data, drawn from the 1995 and 2008 censuses-years that encompass the transition period, enable a dynamic investigation of the liberalization process by comparing labor market outcomes for Israeli Jews and Muslims of both genders working in the public or private sector. Liberalization reduced the protective role of the public sector, especially hurting women of both ethnic groups. In the private sector this process improved the position of the strongest group of Jewish men and of the weakest group of Muslim women. Discrimination against Jewish women and Muslim men in the private sector increased. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. The Liberalization of Canadian Immigration Policy (1945-1976

    Directory of Open Access Journals (Sweden)

    Mariia Burtseva

    2017-07-01

    Full Text Available Immigration policy has played a key role in Canadian history since the second half of 19th century. Certainly, immigration legislation was a major element of it. Some of the most important reforms in Canadian immigration policy took place in the first decades after the Second World War. This was a time of multiple legislative reforms conducted by the Canadian government, but in general, the immigration regulations introduced during that period started the process of liberalization in this area. The Immigration Act of 1976 played a key role in building up the new liberal strategy of Canadian immigration. The pre-reform period is also important because it helps to understand the evolution process from discrimi¬native legislation to liberal policy. Therefore, the focus of this study is on the development of Canadian immigration policy from 1945 to 1976. The present research examines the main preconditions for the adoption of the 1976 Immigration Act. It analyses legislation regulations, which paved the ground for post-war Canadian immigration policy, with a particular emphasis on regula-tions enacted from 1945 to 1976. This article provides an overview of Canadian immigration policy in post-war period. It also identifies successive documents that proved particularly influential for Canadian immigration policy at the time. The findings of this research point to a variety of causes for the legislation changes, from foreign and domestic policy to economy policy.

  13. Autonomy and Liberalism in a Multicultural Society

    Science.gov (United States)

    Jewell, Paul

    2005-01-01

    That children should be educated to be ideal citizens, capable of making rational and informed decisions, has been proposed in cultures ranging from Ancient Greece to current societies. In particular, societies that favour liberalism preach the primacy of the individual autonomous citizen and a concomitant tolerance for others. In modern…

  14. Michael Oakeshott´s Work as a Liberal-Conserv ative Paradigm

    Directory of Open Access Journals (Sweden)

    Josep Baqués

    2014-01-01

    Full Text Available As is the case with other thinkers linked to what can be broadly defined as conservatism, it is arguable whether Michael Oakeshott was just a conservative, or whether he was also a liberal. He often rejected this last label. He also tried to avoid the classic debate between the left/right wing divide, conferring instead a mantle of neutrality on his work. This analysis shows, on the one hand, that Oakeshott´s work is ideologically orientated and, on the other hand, that it contains a substantial liberal component. In fact, he offered a liberal-conservative synthesis in which the free market appears to be not only the best, but the only feasible outcome in the proposed scenario of political prudence. I will fi rst connect Oakeshott with the main traditions of thought, then analyse the theoretical implications of his position, and finally explore the consequences derived from all this for everyday political practice.

  15. The pseudo-scientific psychologyof the economic neo-liberalism

    Directory of Open Access Journals (Sweden)

    Alečković-Nikolić Mila S.

    2014-01-01

    Full Text Available The aim of the paper is to call attention to logical, axiological, psychological and historical foundations of the problem of economic neo-liberalism. The question is how to achieve psychological comprehension of the historical developpement of the idea of scientific reductionism, the idea of 'common law' and rational utilitarism (Hobbes, Locke, Smith, Bentham, of rationalism (Kant and socialism (Rousseau. In the second part of this analysis the aim is to show that the theory of mechanical simplification in the comprehension of human society is logically wrong theory and that this logically wrong theory is the premise of the social totalitarianism. Finally, the goal of our analysis (specially relevant for the Serbian society trapped today is to show that the world of actual financial reductionism and economic neo-liberalism does not understand at all the real human nature.

  16. Drogas, economia, tributação e a ética liberal Drugs, economy, taxation and liberal ethics

    Directory of Open Access Journals (Sweden)

    Luís Fernando Moreira

    2012-07-01

    Full Text Available A guerra contra as drogas está longe de ser efetiva na redução da procura e da oferta neste mercado. Como o custo para fazer cumprir a atual legislação sobre drogas é muito elevado, a sociedade mundial deve avaliar a capacidade estatal para fazer cumprir a proibição, e o resultado real que um combate truculento ao ­tráfico tem produzido. Ao apresentar evidências de que a guerra contra as drogas tem apresentado resultados pouco satisfatórios, uma política mais racional - baseada na ética liberal - é apresentada para lidar com a questão.The ongoing war on drugs is far from being effective in reducing either the demand or supply side of the market. As the costs of enforcing the drug laws are very high, the global community should consider the feasibility of prohibition and the real results that have been achieved so far. Presenting evidence that the results of the war on drugs are largely unsatisfactory, a simpler model based on liberal ethics is proposed to deal with this matter.

  17. R.F.A. Hoernlé and Idealist Liberalism in South Africa1 | Sweet ...

    African Journals Online (AJOL)

    ... by key features of Hoernlé's South African experience. Hoernlé's idealist liberalism, I maintain, not only offered a response to the challenges of living in a multi-ethnic and multi-racial state such as South Africa in the first half of the 20th century, but bears on similar challenges found in contemporary liberal democracies.

  18. Enhancing the Relevance and Value of Marketing Curriculum Outcomes to a Liberal Arts Education

    Science.gov (United States)

    Petkus, Ed, Jr.

    2007-01-01

    Could marketing coursework be part of the general education requirements for all college students? This article describes the ways in which the professional school marketing curriculum model (Schibrowsky, Peltier, & Boyt, 2002) can complement and enhance liberal arts education outcomes. First, the general relationship between liberal arts…

  19. Conservative Soft Power: Liberal soft power bias and the ‘hidden’ attraction of Russia

    DEFF Research Database (Denmark)

    Keating, Vincent Charles; Kaczmarska, Katarzyna

    2018-01-01

    The study of soft power in international relations suffers from a liberal democratic bias. Throughout the literature, liberal concepts and values are assumed to be universal in their appeal. This bias has led scholars to underestimate Russian soft power by instrumentalizing it, that is, to see it...

  20. The Limits of Political Liberalism and Public Reason

    Czech Academy of Sciences Publication Activity Database

    Hrubec, Marek

    2010-01-01

    Roč. 4, č. 4 (2010), s. 52-61 ISSN 1671-4318 R&D Projects: GA MŠk(CZ) LC06013 Institutional research plan: CEZ:AV0Z90090514 Keywords : public reason * liberalism * John Rawls Subject RIV: AA - Philosophy ; Religion

  1. Liberation From Mechanical Ventilation in Critically Ill Adults

    DEFF Research Database (Denmark)

    Ouellette, Daniel R; Patel, Sheena; Girard, Timothy D

    2017-01-01

    BACKGROUND: An update of evidence-based guidelines concerning liberation from mechanical ventilation is needed as new evidence has become available. The American College of Chest Physicians (CHEST) and the American Thoracic Society (ATS) have collaborated to provide recommendations to clinicians ...

  2. Liberal Arts Education in Qatar: Intercultural Perspectives

    Science.gov (United States)

    Rostron, Magdalena

    2009-01-01

    This paper is an attempt to sketch a historical, cultural and social background of recent educational developments in Qatar, briefly review the traditions of western liberal arts education with its goals and teaching and learning methodologies, explain its benefits and their relevance to Muslim Qatari students of universities in Education City in…

  3. Liberal Grading Improves Evaluations But Not Performance.

    Science.gov (United States)

    Vasta, Ross; Sarmiento, Robert F.

    Two grading distributions--a liberal and a more stringent curve--were compared between two sections of an undergraduate psychology course. The two classes were team taught and treated as similarly as possible. Four unit exams and an optional final were administered, with one section consistently receiving a more lenient grade distribution. No…

  4. The Composer in the Liberal Arts College

    Science.gov (United States)

    Schwartz, Elliott

    2011-01-01

    This essay explores the role of music composition within the curriculum of a typical small liberal arts college and the faculty composer's role(s) in facilitating the study of composition. The relationship between composition and campus performance is discussed, particularly in light of the increased emphasis on performance in formerly all-male…

  5. Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?

    Directory of Open Access Journals (Sweden)

    Bailey Steven W

    2009-08-01

    Full Text Available Abstract Background Ireland is an example of a country that has extensive voluntary fortification with folic acid. After a public consultation process, in 2006, the Food Safety Authority in Ireland FSAI 1 recommended mandatory fortification. However due to safety considerations this decision is now on hold. Before mandatory fortification goes ahead, existing levels of unmetabolised folic acid and their anticipated increase after fortification needs investigation because of the potential of folic acid to mask pernicious anaemia and possibly accelerate the growth of existing cancers. The aim of this study was to examine the levels of circulatory unmetabolised folic acid in Irish adults (both fasted and un-fasted and new-born infants (fasted before the proposed implementation of mandatory folic acid fortification. A secondary aim was to predict the increase in circulatory unmetabolised folic acid levels after fortification. Methods Study 1. Setting: Irish Blood Transfusion Service (IBTS. Whole blood samples were collected from blood donors (n = 50 attending for routine blood donation sessions (representing the general population. Subjects were not fasted prior to sampling. Study 2. Setting: Coombe Women's and Infant's University Hospital, Dublin. Whole blood samples were collected by venipuncture from mothers (n = 20, and from their infant's umbilical-cords (n = 20 immediately after caesarean section. All women had been fasted for at least 8 hours prior to the surgery. A questionnaire on habitual and recent dietary intakes of folic acid was administered by an interviewer to all subjects. The data collection period was February to April 2006. Serum samples were analysed for plasma folate, plasma folic acid and red cell folate. Results Blood Donor Group: Circulatory unmetabolised folic acid was present in 18 out of 20 mothers (fasted (CI: 68.3%–99.8% comprising 1.31% of total plasma folate, 17 out of 20 babies (fasted (CI: 62.1%–96.8%, and 49 out

  6. Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?

    LENUS (Irish Health Repository)

    Sweeney, Mary R

    2012-02-01

    BACKGROUND: Ireland is an example of a country that has extensive voluntary fortification with folic acid. After a public consultation process, in 2006, the Food Safety Authority in Ireland FSAI 1 recommended mandatory fortification. However due to safety considerations this decision is now on hold. Before mandatory fortification goes ahead, existing levels of unmetabolised folic acid and their anticipated increase after fortification needs investigation because of the potential of folic acid to mask pernicious anaemia and possibly accelerate the growth of existing cancers. The aim of this study was to examine the levels of circulatory unmetabolised folic acid in Irish adults (both fasted and un-fasted) and new-born infants (fasted) before the proposed implementation of mandatory folic acid fortification. A secondary aim was to predict the increase in circulatory unmetabolised folic acid levels after fortification. METHODS: Study 1. Setting: Irish Blood Transfusion Service (IBTS). Whole blood samples were collected from blood donors (n=50) attending for routine blood donation sessions (representing the general population). Subjects were not fasted prior to sampling. Study 2. Setting: Coombe Women\\'s and Infant\\'s University Hospital, Dublin. Whole blood samples were collected by venipuncture from mothers (n=20), and from their infant\\'s umbilical-cords (n=20) immediately after caesarean section. All women had been fasted for at least 8 hours prior to the surgery. A questionnaire on habitual and recent dietary intakes of folic acid was administered by an interviewer to all subjects. The data collection period was February to April 2006. Serum samples were analysed for plasma folate, plasma folic acid and red cell folate. RESULTS: Blood Donor Group: Circulatory unmetabolised folic acid was present in 18 out of 20 mothers (fasted) (CI: 68.3%-99.8%) comprising 1.31% of total plasma folate, 17 out of 20 babies (fasted) (CI: 62.1%-96.8%), and 49 out of 50 blood donors

  7. Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?

    LENUS (Irish Health Repository)

    Sweeney, Mary R

    2009-01-01

    BACKGROUND: Ireland is an example of a country that has extensive voluntary fortification with folic acid. After a public consultation process, in 2006, the Food Safety Authority in Ireland FSAI 1 recommended mandatory fortification. However due to safety considerations this decision is now on hold. Before mandatory fortification goes ahead, existing levels of unmetabolised folic acid and their anticipated increase after fortification needs investigation because of the potential of folic acid to mask pernicious anaemia and possibly accelerate the growth of existing cancers. The aim of this study was to examine the levels of circulatory unmetabolised folic acid in Irish adults (both fasted and un-fasted) and new-born infants (fasted) before the proposed implementation of mandatory folic acid fortification. A secondary aim was to predict the increase in circulatory unmetabolised folic acid levels after fortification. METHODS: Study 1. Setting: Irish Blood Transfusion Service (IBTS). Whole blood samples were collected from blood donors (n=50) attending for routine blood donation sessions (representing the general population). Subjects were not fasted prior to sampling. Study 2. Setting: Coombe Women\\'s and Infant\\'s University Hospital, Dublin. Whole blood samples were collected by venipuncture from mothers (n=20), and from their infant\\'s umbilical-cords (n=20) immediately after caesarean section. All women had been fasted for at least 8 hours prior to the surgery. A questionnaire on habitual and recent dietary intakes of folic acid was administered by an interviewer to all subjects. The data collection period was February to April 2006. Serum samples were analysed for plasma folate, plasma folic acid and red cell folate. RESULTS: Blood Donor Group: Circulatory unmetabolised folic acid was present in 18 out of 20 mothers (fasted) (CI: 68.3%-99.8%) comprising 1.31% of total plasma folate, 17 out of 20 babies (fasted) (CI: 62.1%-96.8%), and 49 out of 50 blood donors

  8. Different sources of omega-3 polyunsaturated fatty acids affects apparent digestibility, tissue deposition, and tissue oxidative stability in growing female rats

    Directory of Open Access Journals (Sweden)

    Benedito Vagner A

    2011-10-01

    Full Text Available Abstract Background Numerous health benefits associated with increased omega-3 polyunsaturated fatty acid (n-3 PUFA consumption has lead to an increasing variety of available n-3 PUFA sources. However, sources differ in the type, amount, and structural form of the n-3 PUFAs. Therefore, the objective of this study was to determine the effect of different sources of ω-3 PUFAs on digestibility, tissue deposition, eicosanoid metabolism, and oxidative stability. Methods Female Sprague-Dawley rats (age 28 d were randomly assigned (n = 10/group to be fed a high fat 12% (wt diet consisting of either corn oil (CO or n-3 PUFA rich flaxseed (FO, krill (KO, menhaden (MO, salmon (SO or tuna (TO oil for 8 weeks. Rats were individually housed in metabolic cages to determine fatty acid digestibility. Diet and tissue fatty acid composition was analyzed by gas chromatography and lipid classes using thin layer chromatography. Eicosanoid metabolism was determined by measuring urinary metabolites of 2-series prostaglandins (PGs and thromoboxanes (TXBs using enzyme immunoassays. Oxidative stability was assessed by measuring thiobarbituric acid reactive substances (TBARS and total antioxidant capacity (TAC using colorimetric assays. Gene expression of antioxidant defense enzymes was determined by real time quantitative polymerase chain reaction (RT-qPCR. Results Rats fed KO had significantly lower DHA digestibility and brain DHA incorporation than SO and TO-fed rats. Of the n-3 PUFA sources, rats fed SO and TO had the highest n-3 PUFAs digestibility and in turn, tissue accretion. Higher tissue n-3 LC-PUFAs had no significant effect on 2-series PG and TXB metabolites. Despite higher tissue n-3 LC-PUFA deposition, there was no increase in oxidation susceptibility indicated by no significant increase in TBARS or decrease in TAC and gene expression of antioxidant defense enzymes, in SO or TO-fed rats. Conclusions On the basis that the optimal n-3 PUFA sources should

  9. Synergies of the Liberalization of the Railway Transport Market

    Directory of Open Access Journals (Sweden)

    Panák Michal

    2017-01-01

    Full Text Available The liberalization of transport market brings various effects, which in the context of the assessment of synergies can affect in different ways the company, a customer as such, and transport undertakings operating on the railway transport market as well. This paper provides an innovative perspective on the relationship between liberalization and synergy, defining new types of synergies that have not yet been monitored in the conditions of railway transport. This approach is interesting because of the possibility of assessing the operation of railway undertakings in the open transport market. The eminent is characteristic of integration type synergies and emergence type synergies in relation to railway transport, as well as the breakdown of synergies in relation to the customer and carrier.

  10. Cultural Effects of Trade Liberalization

    OpenAIRE

    Steven M. Suranovic; Robert Winthrop

    2005-01-01

    We incorporate culture into a standard trade model in two distinct ways. In the ¡°cultural affinity from work¡± model, workers receive a non- pecuniary cultural benefit from work in a particular industry. In the ¡°cultural externality¡± model, consumers of a product receive utility from other consumer¡¯s consumption of a domestic good. We show that resistance to change due to cultural concerns can reduce the national benefits from trade liberalization. Complete movements to free trade will ha...

  11. GLOBALIZATION AND TRADE LIBERALIZATION: “A THREAT OR AN OPPORTUNITY”?

    Directory of Open Access Journals (Sweden)

    Andrei-Stefan Enghiş

    2006-07-01

    Full Text Available The present paper attempts to evaluate the global economic system through the perspective of neoliberalism, which advocates for the continuous liberalization of trade and the progressive opening of the markets in different economic sectors. Seeking to observe the neoliberal vision on the world economy, the study relies on two speeches delivered by the former European Union’s Trade Commissioner, Pascal Lamy in a time span of four years, between 2000 and 2004, a period marked by two important WTO Ministerial Conferences: the Doha 2001 WTO Ministerial Conference and the Cancun 2003 WTO Ministerial Conference. Nonetheless, in order to provide a balanced analysis of the world economic system, the study provides a brief introspection into the other theoretical vision, alterglobalism, which advocates for a different understanding of the relations between trade liberalization, state intervention in the economy and the reduction of the existent economic disparities. The analysis is divided into three sections: the first section portrays the two antithetical visions, neoliberalism and alterglobalism, while the second one focuses exclusively on the person of Pascal Lamy and on the speeches that represent the core of this study. The third section consists in a comparative analysis of the two divergent economic perspectives, trying to identify the main opposing points, as well as those points on which the two economic perspectives may converge. The conclusion looks closely at the relations between globalization and trade liberalization and the criticism brought about by alterglobalism, the archrival of neoliberalism and trade liberalization. It also considers the relation between the two neoliberal speeches of the former EU Trade Commissioner, attempting to identify potential links or divergent attitudes between the two.

  12. The EU's Major Electricity and Gas Utilities since Market Liberalization

    International Nuclear Information System (INIS)

    Schulke, Ch.

    2010-01-01

    A major change has taken place in the company structure of the European electricity and gas markets. Twenty years ago, national or regional monopolies dominated the markets and there was strictly no competition between utilities. But since the liberalization of EU energy markets began in the 1990's, companies like E.ON, GDF Suez, EDF, Enel, and RWE have become European giants with activities in a large number of Member States. The advocates of market liberalization did not expect, or even intend, the emergence of a small number of large utilities that control an increasing part of the EU market. Some observers already claim that liberalization has led to an oligopoly with detrimental consequences for competition. Based on extensive background research, this book presents a fact-based analysis of the changes in the European utility sector since the 1990's. Case studies of the seven largest utilities illustrate how companies adapted their strategies to the changing market environment. The author underlines diverging choices and common trends like geographic expansion into new markets via mergers and acquisitions or diversification of business activities with the aim of using synergies between electricity and gas. (author)

  13. Contingency, Irony and Morality: A Critical Review of Rorty’s Notion of the Liberal Utopia

    Directory of Open Access Journals (Sweden)

    Wehan Murray Coombs

    2013-06-01

    Full Text Available This paper introduces Richard Rorty’s notion of the liberal ironist and his vision of a liberal utopia and explores the implications of these for philosophical questions concerning morality, as well as morality in general. Rorty’s assertions of the contingency of language, society and self are explored. Under the contingency of language, the figure of the ironist is defined, and Rorty’s conception of vocabularies is discussed. Under the contingency of society, Rorty’s definition of liberalism, his opposition of literary culture to materialist and metaphysical culture, and his notions concerning utopian politics are discussed. Under the contingency of self, Rorty’s critique of Kantian and his appropriations of Deweyan and Freudian conceptions of morality are presented. Other key factors discussed are Rorty’s theory of the separation of the private and public spheres of life and his ideas concerning cruelty and human solidarity. In this way, a critical analysis of Rorty’s proposed balance between private, ironic doubt and public, liberal social hope is presented and assessed in terms of its merit as a system of thought suited to the needs of post-metaphysical, liberal societies.

  14. World History, Liberal Arts, and Global Citizenship

    Science.gov (United States)

    Watt, Carey A.

    2012-01-01

    In this article, the author investigates the role that world history might play in reshaping the liberal arts to better serve a twenty-first-century world that is increasingly interconnected, plural, and "globalized." While "Western civ" courses and perspectives are much less influential today than they were in the first seven decades of the…

  15. Bucking Cultural Norms, Asia Tries Liberal Arts

    Science.gov (United States)

    Fischer, Karin

    2012-01-01

    Sun Yat-sen University's East-meets-West curriculum is distinctive, but its embrace of liberal education--education across disciplines, meant to provoke broad thinking--is far from unusual. At a time when China and its East Asian neighbors are trouncing U.S. students on international exams, educators in these countries are nonetheless adopting,…

  16. Liberal Learning and the World: A Banker's Perspective.

    Science.gov (United States)

    Callander, Robert J.

    1986-01-01

    To address today's global banking issues requires the values and habits of mind that result from liberal education: integrity, critical thinking, moral values, historical consciousness, and ethical development. America's educational and business institutions are mutually dependent and require commitment on both parts. (MSE)

  17. Can new units start up in liberalized markets?

    International Nuclear Information System (INIS)

    Kidd, S.

    2005-01-01

    Power market liberalization had stimulating effect on the nuclear power engineering. It is shown that the operating nuclear power plants blended well into the market medium. Nevertheless the success of the new nuclear power unit is not clear in this market medium [ru

  18. Liberation From Mechanical Ventilation in Critically Ill Adults

    DEFF Research Database (Denmark)

    Schmidt, Gregory A; Girard, Timothy D; Kress, John P

    2017-01-01

    BACKGROUND: This clinical practice guideline addresses six questions related to liberation from mechanical ventilation in critically ill adults. It is the result of a collaborative effort between the American Thoracic Society (ATS) and the American College of Chest Physicians (CHEST). METHODS: A ...

  19. Contesting 'Patriotic History': Zimbabwe's liberation war history and ...

    African Journals Online (AJOL)

    Remarkably, the article observes that the exclusively women authored anthology on liberation war history offers an inventory of a gender based trajectory of memory, thus ... On the other hand, the sidelined demographic categories contest narrow 'patriotic history' by engineering counter discursive historical accounts.

  20. Approaching Political Philosophy through the Critique of Liberalism

    DEFF Research Database (Denmark)

    Sørensen, Asger

    2014-01-01

    Understanding political philosophy as practical implies reflecting on principles as well as on material matters, on justice as well as on government. Liberalism is the main challenge to political philosophy, since its optimistic laissez faire attitude denies the legitimacy of political government...

  1. Relation of fatty acid composition in lead-exposed mallards to fat mobilization, lipid peroxidation and alkaline phosphatase activity

    Science.gov (United States)

    Mateo, R.; Beyer, W.N.; Spann, J.W.; Hoffman, D.J.

    2003-01-01

    The increase of n-6 polyunsaturated fatty acids (PUFA) in animal tissues has been proposed as a mechanism of lead (Pb) poisoning through lipid peroxidation or altered eicosanoids metabolism. We have studied fatty acid (FA) composition in liver and brain of mallards (Anas platyrhynchos) feeding for 3 weeks on diets containing combinations of low or high levels of vitamin E (20 or 200 UI/kg) and Pb (0 or 2 g/kg). Saturated FA, n-6 PUFA and total concentrations of FA were higher in livers of Pb-exposed mallards, but not in their brains. The percentage of n-6 PUFA in liver and brain was slightly higher in Pb-exposed mallards. The increase of n-6 PUFA in liver was associated with decreased triglycerides and increased cholesterol in plasma, thus could be in part attributed to feed refusal and fat mobilization. The hepatic ratios between adrenic acid (22:4 n-6) and arachidonic acid (20:4 n-6) or between adrenic acid and linoleic acid (18:2 n-6) were higher in Pb exposed birds, supporting the existing hypothesis of increased fatty acid elongation by Pb. Among the possible consequences of increased n-6 PUFA concentration in tissues, we found increased lipid peroxidation in liver without important histopathological changes, and decreased plasma alkaline phosphatase activity that may reflect altered bone metabolism in birds.

  2. A Profound Unknowing The Challenge of Religion in the Liberal Education of World Citizens

    Science.gov (United States)

    Gummer, Natalie

    2005-01-01

    Discussions of world citizenship that elide the challenge of grappling with religious worldviews expose a covert intolerance at the very core of secularism, calling into question the "liberality" of liberal education. The ethical imperative of engaging with different worldviews not only demands that religions be taught, but also raises questions…

  3. Middle-class Gothenburg, Jewish Participation, and the Limits of Liberal Tolerance 1870-1900

    Directory of Open Access Journals (Sweden)

    Christoph Leiska

    2012-07-01

    Full Text Available This article discusses the extent and conditions of Jewish participation in Swedish society c. 1870-1900. Whereas earlier research on Jewish history in Sweden had pictured this period as a time of peaceful integration, recent studies have stressed the continuities of cultural representations of ‘the Jew’ as essentially different from ‘the Swede’. Taking the city of Gothenburg as an example, this article offers a new approach by discussing the role of conflicting national and urban elements within liberal self-identification. With regard to urban identities, attitudes of toleration and religious pluralism went side by side with the liberal representation of Gothenburg as being different – different from its rural hinterland, but also from the capital Stockholm. These images of Gothenburg as being exceptionally progressive and open-minded facilitated Jewish participation in the city’s communal politics and associational life. On a national level, however, the ambiguities of Swedish liberal thinking persisted: An increasingly politicised discussion about national identity from the 1880s onwards reveals that the protagonists of Gothenburg liberalism had far greater difficulties in including Jews into their vision of the Swedish nation than the imagined liberties of Gothenburg city culture would suggest.

  4. Research on Simulation Requirements and Business Architecture of Automated Demand Response in Power Sales Side Market Liberalization

    Science.gov (United States)

    Liu, Yiqun; Zhou, Pengcheng; Zeng, Ming; Chen, Songsong

    2018-01-01

    With the gradual reform of the electricity market, the power sale side liberalization has become the focus of attention as the key task of reform. The open power market provides a good environment for DR (Demand Response). It is of great significance to research the simulation requirements and business architecture of ADR (Automatic Demand Response) in power sale side market liberalization. Firstly, this paper analyzes the simulation requirements of ADR. Secondly, it analyzes the influence factors that the business development of ADR from five aspects after power sale side market liberalization. Finally, Based on ADR technology support system, the business architecture of ADR after power sale side market liberalization is constructed.

  5. Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii.

    Science.gov (United States)

    Santos Rosa, C; García Gimenez, M D; Saenz Rodriguez, M T; De la Puerta Vazquez, R

    2007-06-01

    Helichrysum picardii Boiss. & Reuter is a Mediterranean vegetal species from the Asteraceae family. From the methanolic extract of the aerial flowering parts of this plant, a fraction of two pentacyclic triterpenes has been isolated. Gas chromatography revealed that the triterpene isomers ursolic and oleanolic acids comprised 69% and 29% respectively of the composition of this fraction. The triterpene isomeric fraction was tested in two phagocyte cell systems. It inhibited compound 48/80-induced histamine release from rat peritoneal mast cells in an approximately percentage of 45% at 100 microM and myeloperoxidase secretion from A23187-ionophore-stimulated rat peritoneal leukocytes in a significant manner at doses of 50 and 100 miroM. Furthermore, the triterpene isomers very significantly and dose-dependently inhibited generation of the cyclo-oxygenase metabolite prostaglandin E2 (41% inhibition at 50 miroM) and the 5-lipoxygenase metabolite leukotriene B4 (79% inhibition at 50 microM) from activated rat leukocytes. This anti-eicosanoid activity of the triterpene fraction was more potent than that produced by the pure triterpene oleanolic acid used for comparision, indicating a stronger action of the ursolic acid, the major compound of the isolated triterpene fraction. From these data, it can be suggested that the triterpene isomers oleanolic and ursolic acids present in the medicinal plant Helichrysum picardii contribute to the anti-inflammatory profile of this vegetal species.

  6. Freire and liberation theology: the political-Christian choice of two popular educators

    Directory of Open Access Journals (Sweden)

    Miryan Zúñiga Escobar

    2017-06-01

    Full Text Available This article honors Paulo Freire since the autobiographical accounts of two women religious of the Cali Popular Education Network who have been consistent with that Freirean claim that "we can not accept the neutrality of the churches in the face of history" (Freire, 1974, p.24. These stories intertwine the liberating pedagogy of Freire with the emphatic option for the poor of Liberation Theology as they are based on the political-pedagogical action of its protagonists

  7. Protocols for the measurement of the F2-isoprostane, 15(S)-8-iso-prostaglandin F2α, in biological samples by GC-MS or GC-MS/MS coupled with immunoaffinity column chromatography.

    Science.gov (United States)

    Tsikas, Dimitrios; Suchy, Maria-Theresia

    2016-04-15

    Arachidonic acid, the origin of the eicosanoids family, occurs in biological samples as free acid and as ester in lipids. Free arachidonic acid is oxidized to numerous metabolites by means of enzymes including cyclooxygenase (COX). Arachidonic acid esterified to lipids is attacked by reactive oxygen species (ROS) to generate numerous oxidized arachidonic acid derivatives. Generally, it is assumed that ROS-derived arachidonic acid derivatives are distinct from those generated by enzymes such as COX. Therefore, ROS-generated eicosanoids are considered specific biomarkers of oxidative stress. However, there are serious doubts concerning a strict distinction between the enzyme-derived eicosanoids and the ROS-derived iso-eicosanoids. Prominent examples are prostaglandin F2α (PGF2α) and 15(S)-8-iso-prostaglandin F2α (15(S)-8-iso-PGF2α) which have been originally considered to exclusively derive from COX and ROS, respectively. There is convincing evidence that both COX and ROS can oxidize arachidonic acid to PGF2α and 15(S)-8-iso-PGF2α. Thus, many results previously reported for 15(S)-8-iso-PGF2α as exclusive ROS-dependent reaction product, and consequently as a specific biomarker of oxidative stress, require a careful re-examination which should also consider the analytical methods used to measure 15(S)-8-iso-PGF2α. This prominent but certainly not the only example underlines more than ever the importance of the analytical chemistry in basic and clinical research areas of oxidative stress. In the present work, we report analytical protocols for the reliable quantitative determination of 15(S)-8-iso-PGF2α in human biological samples including plasma and urine by mass spectrometry coupled to gas chromatography (GC-MS, GC-MS/MS) after specific isolation of endogenous 15(S)-8-iso-PGF2α and the externally added internal standard [3,3',4,4'-(2)H4]-15(S)-8-iso-PGF2α by immunoaffinity column chromatography (IAC). 15(S)-8-iso-PGF2α esterified to plasma lipids is

  8. No Dilemma at All: The Importance of Liberal Education in Developing Skills for Employability

    Science.gov (United States)

    MacKay, D. Bruce

    2010-01-01

    Some suggest there is a dilemma in post-secondary education between the tidal pulls of career- or disciplinary-oriented education and liberal education. A survey of University of Lethbridge alumni indicated that they found their liberal education important for developing skills that are valuable in life and work after graduation. Specific skills…

  9. Welfare effects of mergers and multilateral trade liberalization

    NARCIS (Netherlands)

    Ray Chaudhuri, A.; Benchekroun, H.

    2012-01-01

    In a two-country model where firms behave à la Cournot, we show that trade liberalization increases (decreases) the social desirability of those mergers that generate sufficiently large (small) reductions in marginal cost. There exists a range of intermediate levels of marginal cost savings such

  10. Financial liberalization and economic growth : A meta-analysis

    NARCIS (Netherlands)

    Bumann, Silke; Hermes, Niels; Lensink, Robert

    This study provides a systematic analysis of the empirical literature on the relationship between financial liberalization and economic growth by conducting a meta-analysis, based on 441 t-statistics reported in 60 empirical studies. We focus on explaining the heterogeneity of results in our sample

  11. A neorepublican cultural citizenship : beyond Marxism and liberalism

    NARCIS (Netherlands)

    Vega, Judith

    2010-01-01

    The idea of cultural citizenship is often associated with a present-day context of multiculturalism, and seen as a novel issue for political philosophy. Within political philosophy it has been mainly conceptualised within a liberal tradition focusing on (cultural) rights. The concept also features

  12. Preferential oxidation of linolenic acid compared to linoleic acid in the liver of catfish (Heteropneustes fossilis and Clarias batrachus)

    International Nuclear Information System (INIS)

    Bandyopadhyay, G.K.; Dutta, J.; Ghosh, S.

    1982-01-01

    The fate of [1(- 14 C] linoleic acid and [1( 14 C] linolenic acid in the liver slices and also in the liver tissues of live carnivorous catfish, Heteropneustes fossilis and Clarias batrachus, was studied. Incorporation of the fatty acids into different lipid classes in the live fish differed greatly from the tissue slices, indicating certain physiological control operative in vivo. The extent of desaturation and chain elongation of linoleic and linolenic acids into long-chain polyunsaturated fatty acids was low. Linolenic acid was oxidized (thus labeling the saturated fatty acid with liberated 14 C-acetyl-CoA) in preference to linoleic acid, and this oxidation also seemed to be under physiological control since both of the fatty acids were poorly oxidized in the tissue slices and in the killed fish. These fish can therefore recognize the difference in the acyl chain structures of linoleate and linolenate. The higher oxidation of linolenic acid and poor capacity for its conversion to longer chain, highly unsaturated derivatives indicates a higher demand for the dietary supply of these essential fatty acids in these two species

  13. Authoritarian populism contra "Bildung": anti-intellectualism and the neoliberal assault on the Liberal Arts

    Directory of Open Access Journals (Sweden)

    Jeremiah Morelock

    2017-12-01

    Full Text Available A synergistic movement is taking place in American society combining authoritarian populism, the neoliberal transformation of the university, and anti-intellectualism. In the first part of this paper, I pin my notion of intellectualism (and hence anti-intellectualism to a specific frame of reference, namely the German notion of "Bildung" as it is discussed in writings of Nietzsche and Adorno, which I associate loosely with the traditional American liberal arts model of higher education. In the second part of the paper, I outline the neoliberal assault on the liberal arts, rooting my analysis in Wendy Brown’s work, which is influenced by Foucault. In the third part of the paper, I describe the relationship of this anti-intellectualism to the rise of populism and the threat of authoritarianism in the United States. In the final section I tie the discussion into the general analysis of Horkheimer and Adorno’s analysis of fascist tendencies in liberal-democracies, emphasizing the continued relevance of their ideas to contemporary developments in education and beyond. Keywords: Liberal arts; Neoliberalism; Intellectuals; Populism; Authoritarianism.

  14. Trade liberalization: Poverty's friend or foe? | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2006-11-14

    Nov 14, 2006 ... By combining the predicted income and consumer price results of the ... In this case, the indicators were: the poverty headcount to measure ... expand to exploit new opportunities afforded in the export market. ... Cockburn's analysis challenges many long-held notions about trade liberalization and poverty.

  15. Recovering What Was Forgotten: Sexuality and Radical Politics in the Homosexual Liberation Movement in Colombia

    Directory of Open Access Journals (Sweden)

    José Fernando Serrano Amaya

    2012-12-01

    Full Text Available What was the meaning of “liberation” in the Homosexual Liberation Movement that emerged in Colombia at the end of the 1970s? El Otro, a homosexual magazine published at that time, is analyzed as a space where a particular discourse about sexuality took form based on the publication’s radical politics. In this discourse, the relationship between sexuality and liberation was understood as revolution, pragmatics, pedagogy and bond, however it became impossible to continue these countercultural liberation politics as rights discourses came to dominate the gay and lesbian movements in 1980s.

  16. Cotton Trade Liberalizations and Domestic Agricultural Policy Reforms: A Partial Equilibrium Analysis

    OpenAIRE

    Pan, Suwen; Fadiga, Mohamadou L.; Mohanty, Samarendu; Welch, Mark

    2006-01-01

    This paper analyzed the effects of trade liberalizing reforms in the world cotton market using a partial equilibrium model. The simulation results indicated that a removal of domestic subsidies and border tariffs for cotton would increase the amount of world cotton trade by an average of 4% in the next five years and world cotton prices by an average of 12% over the same time horizon. The findings indicated that under the liberalization policy, the United States would lose part of its export ...

  17. An overview of liberation theology in orthodox Russia

    Directory of Open Access Journals (Sweden)

    Alexander I. Negrov

    2005-10-01

    Full Text Available The aim of this article is to demonstrate the presence of a theological system of socio-critical and socio-pragmatic strands within Russian Christianity at the beginning of the twentieth century. The political and social situation in Russia at that time was reflected in a reading of the New Testament that went far beyond the more customary ecclesiastic, dogmatic and ethical issues that had traditionally concerned Russian Orthodox theology. Among the Orthodox thinkers there were two camps that focused on anti-oppression issues. Some combined these issues with the liberationist ideology of the Russian Marxists and Socialists; while the other regarded these liberation movements as an anti-Christian way of interpreting Christianity. This article further claims that certain modern developments in Liberation Theology can be found in the period during which the Russian religious thinkers attempted to develop a theological perspective which paid attention to the social and political dimensions inherent in social democracy (Marxism.

  18. Trade Liberalization and the Degree of Competition in International Duopoly

    DEFF Research Database (Denmark)

    Ashournia, Damoun; Hansen, Per Svejstrup; Hansen, Jonas Worm

    2013-01-01

    This paper analyzes how a reduction in trade costs influences the possibility for firms to engage in international cartels, and hence how trade liberalization affects the degree of competition. We consider a particular intra-industry trade model amended to allow for firms producing differentiated...... products. Our main finding is that trade liberalization may have an anti-competitive effect. We find that there is no unique relation between a reduction in trade costs and the degree of competition. When products are differentiated, a lowering of trade costs is pro-competitive if trade costs are initially...... high, but anti-competitive if trade costs initially are low. Hence, trade policy is not necessarily a substitute for competition policy...

  19. Conspirators in a Neo-Liberal Agenda? Adult Educators in Second-Chance Private Training Establishments

    Science.gov (United States)

    Walker, Judith

    2008-01-01

    This paper presents the findings of a qualitative study that explored the impact of neo-liberal policy and ideology on educators and directors working in second-chance Private Training Establishments (PTEs) which were created at the height of the neo-liberal reforms in New Zealand. By examining the experiences of 14 educators and directors in four…

  20. Liberation of plasma histamine after application of non-ionic contrast media

    International Nuclear Information System (INIS)

    Weiss, H.D.; Jansen, O.; Schallock, J.

    1989-01-01

    In 94 patients the levels of plasmahistamine have been measured after application of three non-ionic contrast media (Iopromid, Iopamidol, Iohexol) and after application of blood-isotonic saline solution. A significant liberation of histamine could be observed after administration of contrast media and also after administration of saline solution. Neither between the three nonionic contrast media nor between the contrast media and the saline solution significant differences could be measured. Administering contrast media after subsequently saline solution the levels of histamine were lower than in case of pure contrast media application. A psychogen induced histamine liberation is discussed. (orig.) [de

  1. Retracing liberalism and remaking nature: designer children, research embryos, and featherless chickens.

    Science.gov (United States)

    Fox, Dov

    2010-05-01

    Liberal theory seeks to achieve toleration, civil peace, and mutual respect in pluralistic societies by making public policy without reference to arguments arising from within formative ideals about what gives value to human life. Does it make sense to set aside such conceptions of the good when it comes to controversies about stem cell research and the genetic engineering of people or animals? Whether it is reasonable to bracket our world-views in such cases depends on how we answer the moral questions that the use of these biotechnologies presuppose. I argue that the moral language of liberal justice - of rights and duties, interests and opportunities, freedom and consent, equality and fairness - cannot speak to these underlying concerns about what the human embryo is, why the natural lottery matters to us, and whether 'animal nature' is worth preserving. I conclude that liberal theory is incapable of furnishing a coherent or desirable account to govern the way we use our emerging powers of biotechnology.

  2. Air Transport Liberalization in Europe: The Progress So Far

    Science.gov (United States)

    1998-01-01

    The gradual liberalization of intra-community air services began when Europe's airlines were going through a profitable period (1983-1989), but the more fundamental changes arising from the second (effective November 1990) and especially the third (e...

  3. Modelling dust liberation in bulk material handling systems

    NARCIS (Netherlands)

    Derakhshani, S.M.

    2016-01-01

    Dust has negative effects on the environmental conditions, human health as well as industrial equipment and processes. In this thesis, the transfer point of a belt conveyor as a bulk material handling system with a very high potential place for dust liberation is studied. This study is conducted

  4. Economic Liberalization and Political Violence: Utopia or Dystopia ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-08-06

    Aug 6, 2010 ... Economic Liberalization and Political Violence: Utopia or Dystopia? ... Narrowing the concept of globalization to the more manageable notion of “neoliberalism,” ... Asian outlook: New growth dependent on new productivity ... of its 2017 call for proposals to establish Cyber Policy Centres in the Global South.

  5. Using the decentralized and liberalized electricity market microworld (LEMM) as an educational tool

    International Nuclear Information System (INIS)

    Pasaoglu, Guezay

    2011-01-01

    Decentralized and liberalized electricity market involves a great deal of interdisciplinary concepts, including economic, commercial, environmental and technological issues. Consequently, the system is complicated. Accordingly, nowadays introductory courses focusing on the electricity market dynamics have been added to the curriculum at many universities. However, as the electricity market dynamics are complicated, it is not straightforward for students to understand. A teaching tool to assist students to better understand strategic behaviors in the market is thus in high demand. Due to these reasons, Liberalized Electricity Market Microworld (LEMM), incorporating a system dynamics based simulation model, is developed. The LEMM's contribution to the students learning and understanding of the decentralized and liberalized electricity market dynamics have been explored by organizing game sessions with the LEMM for totally 49 students who participated in 'Energy Policy and Planning' course in Bogazici University. The findings obtained from the exploratory study reveal that the students improved their understanding of the liberalized and decentralized electricity market through the game session with the LEMM. In this paper, the general characteristics of the LEMM and the underlying model are presented, the microworlds', particularly the LEMM's potential contribution to learning and teaching is discussed. - Research highlights: → LEMM describes realistically the dynamics of liberalized and decentralized electricity markets. → LEMM is a system dynamics based microworld used as a teaching tool in universities. → The study reveals that student's learning and understanding improves significantly using LEMM. → Future target groups of the LEMM are energy policy makers and decision makers. → To improve the performance of the training, microworld based game sessions should be used.

  6. Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation.

    Science.gov (United States)

    Liao, Y H; Houghton, P J; Hoult, J R

    1999-09-01

    We have undertaken a systematic survey of the genus Buddleja used in traditional Chinese medicine for antiinflammatory and other indications by testing extracts and isolated natural products for their activity against the enzymes of the arachidonate cascade. This was done by using elicited rat peritoneal leukocytes, a physiologically relevant established whole cell system that expresses both cyclo-oxygenase (COX) and 5-lipoxygenase (5-LOX) activity. Lipophilic extracts of B. globosa roots and B. myriantha stem exhibited inhibitory activities in the 5-LOX and COX enzyme assays, whereas those of B. officinalis flowers, B. yunanesis stems, and B. asiatica stems showed inhibitory activities only against COX. The phytochemical investigation of these extracts, and consequent structure elucidation of isolated compounds using spectroscopic data, led to the isolation from B. globosa of three new terpenoid compounds named dihydrobuddledin A, buddledone A, and buddledone B and four known compounds-buddledins A, B, and C and zerumbone; 12 known compounds from B. officinalis-calceolarioside, campneoside, verbascoside, echinacoside, forsythoside B, angoroside A, crocetin monogentibiosyl ester, acacetin, acacetin-7-O-alpha-L-rhamnopyranosyl (1-6)-beta-D-glucopyranoside, acacetin-7-O-alpha-L-rhamnopyranosyl (1-6)[alpha-L-rhamnopyranosyl (1-2)]-beta-D-glucopyranoside, songarosaponin A, delta-amyrone; and eight known compounds fromB. yunanesis-11,14-dihydroxy-8,11, 13-abietatrien-7-one, beta-sitosterol, verbascoside, echinacoside, forsythoside B, angoroside A, methylcatapol, and sucrose. Tests on the isolated compounds for inhibition of eicosanoid synthesis showed that buddledin A, crocetin monogentibiosyl ester, and acacetin exhibited an inhibitory effect on COX with IC(50) values of 13.7 microM, 28.2 microM, and 77.5 microM, respectively, whereas buddledin A exhibited inhibitory effect on 5-LOX with an IC(50) value of 50.4 microM.

  7. Liberal egalitarianism and the harm principle

    OpenAIRE

    Lombardi, Michele; Veneziani, Roberto

    2009-01-01

    This paper analyses Rawls's celebrated difference principle, and its lexicographic extension, in societies with a finite and an infinite number of agents. A unified framework of analysis is set up, which allows one to characterise Rawlsian egalitarian principles by means of a weaker version of a new axiom - the Harm Principle - recently proposed by marven09. This is quite surprising, because the Harm principle is meant to capture a liberal requirement of noninterference and it incorporates no...

  8. Comparative study of liberalization process of passengers railway market in Spain and England

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez Morote, G.; Ortuño Padilla, A.; Fernandez Aracil, P.

    2016-07-01

    This article provides an overview of the privatization of railway passengers market in Spain through a background to the most relevant cases studies in Europe, particularly the liberalization process in England. The English case study is a paradigmatic example to assess how the liberalization process was developed and its effect in the present. This assessment has been undertaken to analyse the railway franchise structure, ticketing measures, role of national and regional authorities, etc. and possible analogies to be adapted to the case of Spain. Firstly, this article reviews the origin of the privatization of the railway market in both Spain and England, describing every phase of the liberalization and the success of every stage. Secondly, a critical approach assessment exposes those market failures of the liberalization process in England that caused negative impacts on society. In addition, the role of the Government is analysed to measure their implication in order to solve that situation. Furthermore, the paper expounds a wide analysis of the rail ticketing in England, its effects on increased passenger number. Finally, this article proposes some measures to be followed on the privatization of passenger rail market in Spain, as well as some key concepts to guarantee its success as taken from the case studies that have been reviewed. (Author)

  9. The Old Neo-Liberalism. The Neo-Liberalist Germ in Mises' and Hayek's Theories

    Directory of Open Access Journals (Sweden)

    Vanessa Lamattina

    2016-09-01

    Full Text Available What is neo-liberalism? I’m going to affirm here that, as well as being a political doctrine born in the 1970s, neo-liberalism is the construction, the extension and the final reinforcement of a number of classical elements. My argument is that many of the typical aspects of contemporary neo-liberalism were already present in theories expressed by thinkers such as L. von Mises and F. A. von Hayek. As proof of this fact, I reclaim some characteristics of the present neo-liberal phenomenon as having been conceived by the above authors. These characteristics actually imply the ongoing spread of a dominant ideology that tends to pit the concept of liberty against those of rationality and critical consciousness. First, the article will analyse the changes that have occurred within the phenomenon of consumerism, which becomes en-twined with the competitive and entrepreneurial spirit of the individual; second, it will reflect on the wide-spread aversion to socialist policies, and in fact to all policies that provide for public intervention by the State and that change the relationship between State and economy; finally, it will relate these investiga-tions to the ideological and structural model that supports the European Union.

  10. The New Criticism and the Crisis of American Liberalism: The Poetics of the Cold War.

    Science.gov (United States)

    Walhout, Mark

    1987-01-01

    Contends that arguments against New Criticism should place the movement in historical context. Suggests that historians of American criticism rethink the institutionalization of New Criticism as the work of both liberal intellectuals and pragmatic neoconservatives for whom both traditional liberalism and right-wing ideology were part of the…

  11. Stable isotope signatures of gases liberated from fluid inclusions in bedrock at Olkiluoto

    International Nuclear Information System (INIS)

    Eichinger, F.; Meier, D.; Haemmerli, J.; Diamond, L.

    2010-12-01

    Fluid inclusions in quartzes of the Olkiluoto bedrock contain gaseous N 2 , CO 2 , H 2 , CH 4 , and higher hydrocarbons in varying proportions. Stable carbon and hydrogen isotope signatures of the gas phases give valuable information on their origin and the formation conditions. In previous studies, a method to liberate and quantify the gases trapped in fluid inclusions was developed. It allowed determining the carbon isotope signatures of liberated CO 2 , CH 4 and higher hydrocarbons (HHC), but no hydrogen isotope data were acquired. The method was advanced and, in this study, also stable hydrogen isotopes of CH 4 and H 2 liberated from fluid inclusions could be analysed. The stable carbon signatures of methane and higher hydrocarbons, as well as the hydrogen isotope signatures of methane indicate a predominant thermogenic provenance for those gases. (orig.)

  12. Responding to the challenge of Black Theology: Liberating Ministry ...

    African Journals Online (AJOL)

    2016-08-05

    Aug 5, 2016 ... smart phone or mobile .... relationship between white liberation and Black Theology. ..... uses this language to call for the church to 'become' a site of struggle, which in his ..... itself does not dismantle a problematic whiteness.

  13. Notes and Aporias Between Utilitarianism and Egalitarian Liberalism Rawlsian

    Directory of Open Access Journals (Sweden)

    Nathalia Karollin Cunha Peixoto de Souza

    2016-11-01

    Full Text Available This paper analyzes the convergences and divergences between the utilitarian conception of justice, based on Bentham and Mill, and the liberal-egalitarian conception of justice in Rawls, and explain some latent concepts in both theories.

  14. Infidelity and the Possibility of a Liberal Legal Moralism

    DEFF Research Database (Denmark)

    Thaysen, Jens Damgaard

    2017-01-01

    This paper argues that according to the influential version of legal moralism presented by Moore infidelity should all-things-considered be criminalized. This is interesting because criminalizing infidelity is bound to be highly controversial and because Moore’s legal moralism is a prime example...... of a self-consciously liberal legal moralism, which aims to yield legislative implications that are quite similar to liberalism, while maintaining that morality as such should be legally enforced. Moore tries to make his theory yield such implications, first by claiming that the scope of our moral...... obligations is much more limited than legal moralists have traditionally claimed, and second by allowing for the possibility that the goodness of legally enforcing morality is often outweighed by the badness of limiting citizens’ morally valuable autonomy and spending scarce resources on enforcement. If Moore...

  15. Review: John S. Saul, Liberation Lite: The Roots of Recolonization in Southern Africa (2011)

    OpenAIRE

    Henning Melber; Dag Hammarskjöld Foundation

    2012-01-01

    Review of the monograph: John S. Saul, Liberation Lite: The Roots of Recolonization in Southern Africa, Trenton, N.J.: Africa World Press, 2011, ISBN 978-1-59221-835-6, 133 pages Besprechung der Monographie: John S. Saul, Liberation Lite: The Roots of Recolonization in Southern Africa, Trenton, N.J.: Africa World Press, 2011, ISBN 978-1-59221-835-6, 133 Seiten

  16. ‘Between life and death’: On land, silence and liberation in the capital city

    Directory of Open Access Journals (Sweden)

    Stephan F. de Beer

    2014-08-01

    Full Text Available This article reflects on the unfinished task of liberation – as expressed in issues of land – and drawing from the work of Franz Fanon and the Durban-based social movement Abahlali baseMjondolo. It locates its reflections in four specific sites of struggle in the City of Tshwane, and against the backdrop of the mission statement of the Faculty of Theology at the University of Pretoria, as well as the Capital Cities Research Project based in the same university. Reflecting on the ‘living death’ of millions of landless people on the one hand, and the privatisation of liberation on the other, it argues that a liberating praxis of engagement remains a necessity in order to break the violent silences that perpetuate exclusion.

  17. In Pursuit of Educational Justice and Liberated Hearts

    Science.gov (United States)

    Mirci, Philip S.

    2008-01-01

    This article contributes to a discussion about educational leadership programs related to social justice and diversity. It focuses on the development of social justice leaders through a doctoral program that culminates in a Doctorate in Educational Justice. The program's design is intended to empower graduates to act with hearts liberated through…

  18. The Crossroads of Liberalism in Journalism and Education.

    Science.gov (United States)

    Wallace, James M.

    Political responses to the "cult of efficiency" in the schools, academic freedom, and the role of education in social reform between 1914 and 1921 are traced in issues of the "Nation" and the "New Republic." The variety within political liberalism at the time was reflected in a similar diversity of educational…

  19. Welfare Effects of Trade Liberalization with Intra-industry Reallocations: The Importance of Preferences and Market Failures

    DEFF Research Database (Denmark)

    Sørensen, Allan

    pref- erences, which ensures equivalence of the market equilibrium and the social planner solution. For other preferences this equivalence is broken and trade liberalization may reduce welfare by magnifying market failures. An exact condition for trade liberalization to reduce overall welfare...

  20. Visiting the neo-liberal university

    DEFF Research Database (Denmark)

    Sørensen, Asger

    2015-01-01

    dramatic controversy ever encountered at a Danish university, the Koldau case, which reached national newspaper headlines and broadcasting in two rounds in 2011 and 2012. In the fourth section, I will interpret the case as an educational controversy in light of two conflicting ideas of the modern...... university, which may be attributed to two leading Enlightenment figures, Wilhelm von Humboldt and Denis Diderot. The conclusion is that to some extent, the failure to resist the neo-liberal university reforms in Denmark and the UK, and the drama of the Koldau case, may be explained with reference...